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Sample records for chilenos con lupus

  1. CUANDO LAS AFRENTAS SE LAVABAN CON SANGRE: HONOR, MASCULINIDAD Y DUELOS DE ESPADAS EN EL SIGLO XVIII CHILENO

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    Verónica Undurraga Schüler

    2008-01-01

    Este trabajo aborda la relación entre honor y prácticas sociales en el siglo XVIII chileno, analizando la figura de los duelos o expresiones de violencia masculina formalizada. Junto con indagar en los mecanismos restitutorios del honor y su vinculación a los fundamentos de una masculinidad tradicional, reflexiona sobre las gamas de manejo social de dicho valor en el período señalado. Teóricamente se rescatan los aportes de la antropología y se hace un balance del tratamiento historiográfico ...

  2. El modelo económico chileno y su relación con Bolivia

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    Quitral Rojas, Máximo

    2009-01-01

    La presente investigación forma parte de una indagación de años y pretende conectar las economías chilena y boliviana en un escenario favorable para el encierro geográfico del país vecino. Durante los regímenes militares chileno y boliviano, y el proceso de transición a la democracia acontecido en Bolivia, perduro en el tiempo una relación bilateral económica apartada de los conflictos políticos presente en la Historia de los Estados en cuestión. Esta dinámica relación fue fomentada desde los...

  3. Manifestaciones mucocutaneas en pacientes con lupus eritematoso sistemico

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    V. Saurit

    2003-08-01

    Full Text Available El objetivo fue estudiar en pacientes con lupus eritematoso sistémico (LES la prevalencia de las lesiones mucocutáneas. Se incluyeron 77 pacientes. Las lesiones mucocutáneas fueron clasificadas en específicas y no específicas. Se definió el fototipo, exposición solar y fotoprotección. Se relacionaron las lesiones con la serología y la actividad de la enfermedad. Las lesiones específicas encontradas fueron: agudas (67.5%, lupus subagudo (6.3% y lesiones crónicas (26.0%. Las lesiones no específicas fueron: alopecia difusa (59%, fotosensibilidad (57%, fenómeno de Raynaud (47%, úlceras orales (16% y livedo reticularis (12%. El fototipo 3 (35% fue predominante; la exposición a las radiaciones ultravioletas fue moderada en 74%. Sólo 47% utilizaron protectores solares. Los anticuerpos anti-Ro se relacionaron en forma significativa con eritema malar, fotosensibilidad, livedo reticularis y alopecia. Los anticuerpos anti-Sm se relacionaron con fenómeno de Raynaud. Todas estas lesiones se observaron con mayor frecuencia en pacientes con enfermedad activa. La prevalencia de las manifestaciones mucocutáneas fue ligeramente más elevada a la informada en otras series. Hubo mayor prevalencia de eritema malar, alopecia difusa, fotosensibilidad y livedo reticularis en pacientes con enfermedad activa y anti-Ro (+ y de fenómeno Raynaud con anti-Sm.(+.The objective was to analyze the prevalence of mucocutaneous lesions in patients with systemic lupus erythematosus (SLE. During a 3-year period, we analyzed 77 patients with a diagnosis of SLE. The mucocutaneous lesions were classified into specific and non-specific. We defined skin type, sunlight exposure and photoprotection and correlated these lesions with serology and disease activity. Acute specific lesions were found in 67.5% of the patients, subacute lupus in 6.5% and chronic lesions in 26.0%. The most prevalent non-specific lesions were alopecia (59.7%, photosensitivity (57.1%, Raynaud

  4. Lupus

    Science.gov (United States)

    What is lupus? Lupus is an autoimmune disease. This means that your immune system attacks healthy cells and tissues by mistake. This can ... vessels, and brain. There are several kinds of lupus Systemic lupus erythematosus (SLE) is the most common ...

  5. Lupus

    Science.gov (United States)

    If you have lupus, your immune system attacks healthy cells and tissues by mistake. This can damage your joints, skin, blood vessels and organs. There are many kinds of lupus. The most common type, systemic lupus erythematosus, affects ...

  6. CUANDO LAS AFRENTAS SE LAVABAN CON SANGRE: HONOR, MASCULINIDAD Y DUELOS DE ESPADAS EN EL SIGLO XVIII CHILENO

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    Verónica Undurraga Schüler

    2008-06-01

    Full Text Available Este trabajo aborda la relación entre honor y prácticas sociales en el siglo XVIII chileno, analizando la figura de los duelos o expresiones de violencia masculina formalizada. Junto con indagar en los mecanismos restitutorios del honor y su vinculación a los fundamentos de una masculinidad tradicional, reflexiona sobre las gamas de manejo social de dicho valor en el período señalado. Teóricamente se rescatan los aportes de la antropología y se hace un balance del tratamiento historiográfico del problema. Desde los registros judiciales se plantea el carácter transversal del honor en términos sociales y se aborda su "doble naturaleza" en cuanto espacio relacional y ámbito de confrontación de los individuos.This works deals with the relationship between honor and social practices in Chile's eighteenth century and analyzes formal duels or expressions of legalized masculine violence. This article explores various manifestations of the social ways used to deal with honor at that time, together with the inquiries about mechanisms used to restore honor and its links with traditional masculinity. Theoretically, this work rescues contributions made by anthropologists and provides an overview of how honor and masculinity have been examined in the historiography. Starting from judicial records, the article considers the transversal character of honor in social terms and approaches its "double significance" as both a relational space for people and as a sphere for the confrontation of individuals.

  7. Lupus

    Science.gov (United States)

    ... ages of 15 and 45. African‑American, Latina, Asian, and Native American women are at greater risk of getting lupus than ... women. Lupus is also more common in Latina, Asian, and Native American women. Men are at a higher risk before puberty ...

  8. Expandiendo el espectro mutacional en pacientes chilenos con fibrosis quística Expanding the CFTR mutation spectrum in Chilean patients with cystic fibrosis

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    Marcos Vásquez D

    2012-06-01

    Full Text Available Introducción: La fibrosis quística (FQ es una enfermedad con herencia autosómica recesiva, que presenta una incidencia de 1 en 8.000 a 9.000 recién nacidos en Chile. A la fecha se han descrito más de 1.800 mutaciones diferentes en el gen CFTR. El diagnóstico molecular disponible consiste en el análisis de las 36 mutaciones presentes con mayor frecuencia en población caucásica, donde se describe una tasa de detección de un 85%. Sin embargo, en Chile el rendimiento corresponde a un 42%. Por esta razón, hemos iniciado un análisis sistemático en la región codificante del gen CFTR con elfin de identificar los restantes alelos en pacientes chilenos con FQ. Métodos: Análisis por secuenciación de los exones 6,7,14,19y 20, en 48pacientes chilenos del Programa Nacional de FQ. Se incluyeron pacientes con criterios clínicos y de laboratorio de FQ, y con sólo una mutación identificada en el panel de 36 mutaciones. Resultados: Se identificaron 3 mutaciones diferentes que no se analizan en el panel de diagnóstico molecular y que no habían sido reportadas en pacientes chilenos, totalizando 14 casos. Cuatro casos corresponden a una nueva mutación en el exón 14, que produce un corrimiento en el marco de lectura y un codón de término prematuro (c.2462_2463delGT/p.Ser821ArgfsX4. Ocho casos presentan la mutación c.3196C>T en el exón 20, mientras que en 2 casos se encontró la mutación c.3039delC en el exón 19. Ambas mutaciones han sido descritas previamente en otras poblaciones. Discusión: La identificación de estas mutaciones ha incrementado notablemente la tasa de detección obtenida en nuestros pacientes. Esto crea la necesidad de adaptar el análisis molecular inicial en pacientes chilenos con FQ, redundando en un diagnóstico de certeza en gran parte de los casos y permitiendo un adecuado asesoramiento genético para las familias.Introduction: Cystic Fibrosis (CF is an autosomal recessive disease and affects 1 in 8000

  9. CALIDAD DE VIDA RELACIONADA CON LA SALUD EN PACIENTES CON LUPUS ERITEMATOSO SISTÉMICO Y SU RELACIÓN CON DEPRESIÓN, ANSIEDAD Y OPTIMISMO DISPOSICIONAL.

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    Juan Manuel Anaya; Ricardo Pineda; Liliana Abad; Carla Zapata; Japcy Margarita Quiceno; Stefano Vinaccia

    2006-01-01

    La siguiente investigación presenta los resultados de un estudio desarrollado en Colombia sobre la evaluación de la calidad de vida y sus relaciones con la depresión, ansiedad y optimismo disposicional en 32 pacientes con diagnóstico de lupus eritematoso sistémico de la Clínica Universitaria Bolivariana de la ciudad de Medellín, Colombia. Para evaluar la calidad de vida se utilizó el Cuestionario SF36, la ansiedaddepresión fue evaluada mediante el Cuestionario HAD, y se trabajó con el Cuestio...

  10. Lupus

    Science.gov (United States)

    ... help with the pain. Others take antimalarial drugs (medicines first developed to prevent and treat malaria, but that have also been found to help treat lupus). Antimalarial drugs often help treat skin rashes and joint pain. Some ... steroids, medicines that help fight the fatigue and fever that ...

  11. Linfoma primario del sistema nervioso central en una paciente con lupus eritematoso sistémico

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    C. N. Pisoni; A. R. Grinberg; J. L. Plana; R. D. Freue; J. A. Manni; Paz, L.

    2003-01-01

    Se presenta una paciente de 36 años con diagnóstico de lupus eritematoso sistémico tratada con prednisona y ciclofosfamida que se internó por cefalea, hemiparesia y hemianestesia braquiocrural derecha de dos semanas de evolución. Se realizó una tomografía computada y una resonancia magnética nuclear de cerebro que mostraron una lesión nodular frontal izquierda. Se efectuó una biopsia a cielo abierto de la lesión cerebral cuyo diagnóstico histopatológico fue linfoma B de celulas grandes, difus...

  12. La inclusión en la educación superior: desde la voz de estudiantes chilenos con discapacidad

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    Salinas Alarcón, Marcela; Lissi, María-Rosa; Medrano Polizzi, Daniela; Zuzulich Pavez, María-Soledad; Hojas Loret, Ana-María

    2013-01-01

    En este artículo se presentan los resultados de un estudio sobre las experiencias en la educación superior de los estudiantes con discapacidad y las principales condiciones que facilitan u obstaculizan el proceso de inclusión. La metodología utilizada fue cualitativa, basada en los principios de la teoría fundamentada. Los participantes entrevistados fueron catorce estudiantes con discapacidad, pertenecientes a dos universidades chilenas. Entre los resultados destacan influencias sociales sig...

  13. Vacunación antineumococo en pacientes con lupus eritematoso sistémico

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    C. Pisoni

    2003-10-01

    Full Text Available Se evaluó la respuesta de anticuerpos específicos, aparición de autoanticuerpos y actividad de la enfermedad en pacientes con lupus eritematoso sistémico (LES luego de la inmunización con vacuna polivalente para neumococo. Se inoculó, con vacuna 23 valente para neumococo, a 37 pacientes con diagnóstico de LES; previamente y a las 12 semanas post vacunación se determinó los autoanticuerpos, el nivel de complemento sérico y la actividad de la enfermedad aplicando el índice SLEDAI y la respuesta de los anticuerpos IgG contra antígenos polisacáridos capsulares. En 30 pacientes (85.7% los anticuerpos duplicaron el valor basal alcanzando de esta manera, el nivel estimado protector. No hubo diferencias estadísticamente significativas en los índices de actividad post vacunación. En conclusión: en esta serie de pacientes lúpicos, la inmunización con vacuna 23 valente no provocó reactivación de la enfermedad, e indujo una adecuada respuesta de anticuerpos en el 85% del grupo. No se registraron efectos adversos generales o locales que motivaran alguna medicación o internación de ningún paciente.The objective of the study was to evaluate antibody response, autoantibodies induction and disease activity in systemic lupus erythematosus (SLE patients after polyvalent pneumococcal vaccination. SLE patients (n 37 were vaccinated with 23 valent pneumococcal vaccine. Systemic lupus erythematosus disease activity index (SLEDAI and specific IgG antibodies against pneumococcus were measured before and after vaccination. After inoculation 30 patients (85.7% duplicated IgG anti pneumococcus baseline value, reaching protective levels of antibodies. We did not find significant differences in disease activity up to three months after vaccination. In conclusion: after vaccination of this lupus population an 85.0% antibody response was obtained, without temporal associated disease flare or any serious adverse event.

  14. Morbimortalidad cardiopulmonar en pacientes con lupus eritematoso sistémico

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    Alicia Aquino Valdovinos; María Isabel Acosta Colmán; Osmar Antonio Centurión; Gabriela Ávila Pedretti; Jhonatan Losanto; Margarita Duarte

    2015-01-01

    Los pacientes con diagnóstico de lupus eritematoso sistémico (LES) presentan una elevada morbi-mortalidad asociada a las manifestaciones cardiopulmonares que se desarrollan durante la evolución de la enfermedad. En este sentido, se han descrito dos picos de incidencia de mortalidad de esta enfermedad inmunológica. El primer pico está relacionado a la actividad de la enfermedad y se observa durante los tres primeros años posteriores al diagnóstico. El segundo pico está relacionado principalmen...

  15. Morbimortalidad cardiopulmonar en pacientes con lupus eritematoso sistémico

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    Alicia Aquino Valdovinos

    2015-08-01

    Full Text Available Los pacientes con diagnóstico de lupus eritematoso sistémico (LES presentan una elevada morbi-mortalidad asociada a las manifestaciones cardiopulmonares que se desarrollan durante la evolución de la enfermedad. En este sentido, se han descrito dos picos de incidencia de mortalidad de esta enfermedad inmunológica. El primer pico está relacionado a la actividad de la enfermedad y se observa durante los tres primeros años posteriores al diagnóstico. El segundo pico está relacionado principalmente a las complicaciones cardiopulmonares y se presenta entre los 4 y 20 años posteriores al diagnóstico. Si bien la mortalidad temprana ha disminuido gracias a un mayor conocimiento de la fisiopatología de la enfermedad y al uso de terapias inmunosupresoras, la mortalidad tardía presenta un aumento progresivo de su frecuencia a pesar del avance en el manejo terapéutico. El estudio de estas complicaciones se ha convertido en un tema de gran interés debido a su efecto negativo en el pronóstico de los pacientes que las presentan. Algunos estudios epidemiológicos sugieren que los pacientes con LES tienen un mayor riesgo cardiovascular al ser comparados con la población sana. En este sentido, se ha descrito que estos presentan un mayor riesgo de desarrollar eventos cardiovasculares (infarto agudo del miocardio, accidente cerebro vascular y enfermedad arterial periférica en comparación con la población general. De forma asociada, se ha objetivado que la presencia de manifestaciones pleuro-pulmonares (pleuritis lúpica, neumonitis, hemorragia pulmonar, embolismo pulmonar e hipertensión pulmonar aumenta la morbimortalidad de los pacientes con LES. El conocimiento adecuado de las complicaciones cardiopulmonares en los pacientes con diagnóstico de lupus eritematoso sistémico permitirá realizar un manejo individualizado y por lo tanto más eficaz, permitiendo disminuir la morbilidad asociada a las citadas complicaciones. El objetivo de este

  16. Prevalencia de dislipidemias en los pacientes con lupus eritematoso sistémico en el Hospital Clínico Regional de Concepción.

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    Michelle Vinet M.; Camila Sanhueza F.; Susana Sabat A.; Andrea Galdames G.; Irene Castro E.

    2011-01-01

    INTRODUCCIÓN: El lupus eritematoso sistémico es considerado un factor de riesgo cardiovascular. En estos pacientes es frecuente hallar dislipidemias. La terapia corticoesteroide favorece las alteraciones lipídicas. HIPÓTESIS: Los pacientes con lupus eritematoso sistémico presentan hipercolesterolemia, hipertrigliceridemia o ambos, en mayor proporción que la población general. OBJETIVO: Determinar la prevalencia de dislipidemias en los pacientes diagnosticados de lupus eritematoso sistémico y ...

  17. CONSENSO CHILENO DE REHABILITACIÓN RESPIRATORIA EN EL PACIENTE CON EPOC: INTRODUCCIÓN Consensus of Respiratory Rehabilitation in Chronic Obstructive Pulmonary Disease Patients: Introduction

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    FRANCISCO ARANCIBIA H

    2011-06-01

    Full Text Available En Chile y el mundo, la enfermedad pulmonar obstructiva crónica (EPOC es un problema de salud pública, debido a su alta prevalencia, su condición progresiva, el deterioro de la calidad de vida y el gran impacto económico. La rehabilitación respiratoria (RR es un tratamiento multidisciplinario y en los pacientes con EPOC permite intervenir el círculo vicioso que limita la capacidad de ejercicio en estos pacientes. Los objetivos de la RR son: reducir los síntomas, mejorar la tolerancia al ejercicio físico y la calidad de vida. Presentamos el primer Consenso Chileno de Rehabilitación Respiratoria en pacientes con EPOC. Estas guías tienen por objetivo que la RR pueda aplicarse en todo el país, tanto en hospitales como en la atención primaria. Para la elaboración de este documento, un grupo de neumonólogos, kinesiólogos, enfermeras, nutricionistas y psicólogos realizó un análisis sistemático de la evidencia científica disponible hasta diciembre de 20l0. La evidencia fue analizada según el sistema GRADE (Grading of Recommendations Assessment, Development and Evaluation modificado. El consenso se dividió en capítulos los cuales analizan en profundidad cada uno de los tópicos de la RR. Estos incluyen fisiopatologia, evaluación y programas, entrenamiento muscular de: extremidades inferiores, superiores y musculatura inspiratoria, oxígenoterapia, ventilación no invasiva, educación, nutrición, aspectos psicológicos y costo-efectividad.In Chile and the world, the chronic obstructive pulmonary disease (COPD is a problem of public health, due to its high prevalence, its progressive condition, the deterioration of the quality of life and its great economic impact. The respiratory rehabilitation (RR is a multidisciplinary treatment and in COPD patients allows to control the vicious circle that limits the capacity of exercise in these patients. The aims of the RR are: to reduce the symptoms, to improve the tolerance to the physical

  18. CALIDAD DE VIDA RELACIONADA CON LA SALUD EN PACIENTES CON LUPUS ERITEMATOSO SISTÉMICO Y SU RELACIÓN CON DEPRESIÓN, ANSIEDAD Y OPTIMISMO DISPOSICIONAL.

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    Juan Manuel Anaya

    2006-06-01

    Full Text Available La siguiente investigación presenta los resultados de un estudio desarrollado en Colombia sobre la evaluación de la calidad de vida y sus relaciones con la depresión, ansiedad y optimismo disposicional en 32 pacientes con diagnóstico de lupus eritematoso sistémico de la Clínica Universitaria Bolivariana de la ciudad de Medellín, Colombia. Para evaluar la calidad de vida se utilizó el Cuestionario SF36, la ansiedaddepresión fue evaluada mediante el Cuestionario HAD, y se trabajó con el Cuestionario DIOP para medir optimismo. El estudio evidenció que los pacientes perciben una calidad de vida favorable en todas las dimensiones que conforman el cuestionario SF36, no se encontraron niveles clínicamente significativos de ansiedad-depresión, y por último se encontró alta predisposición hacia el optimismo.

  19. Contraception in women with systemic erythematosus lupus = Anticoncepción en mujeres con lupus eritematoso sistémico

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    Luis Alonso González Naranjo

    2013-07-01

    Full Text Available The use of contraceptives, particularly of those containing estrogens by women with systemic lupus erythematosus (SLE, has been thought to carry risks such as disease exacerbation, thrombosis and other adverse effects. However, the available evidence suggests that many women with SLE, particularly those with stable disease, are not at increased risk of disease flare while taking oral contraceptives and therefore can be good candidates for most contraceptive methods, including the hormonal ones. Contrariwise, women with positive antiphospholipid antibodies are at increased risk of arterial and venous thrombosis and therefore the use of combined hormonal contraceptive methods should be avoided in them.

  20. UNIPERSONALIDAD Y SOCIEDAD CON UN SOLO SOCIO; ALCANCES DE SU RECONOCIMIENTO EN LA ESTRUCTURA DOGMÁTICA DEL DERECHO CHILENO Unipersonality And Company With Only One Partner; Some Scope Of His Insertion In De Dogmatic Structure Of Chilean Law

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    Eduardo Jequier Lehuedé

    2011-01-01

    Full Text Available La presente investigación surge a partir del definitivo reconocimiento en Chile delfenómeno de la unipersonalidad y, recientemente, de la Sociedad por Acciones -SpA- con un solo socio en su vertiente originaria. Apunta en concreto a explorar el real impacto de la figura unipersonal en la estructura dogmática del derecho chileno y del derecho de sociedades en particular, construida a partir del concepto de sociedad contemplado en el artículo 2053 del Código Civil. Se analiza el origen de la unipersonalidad en el derecho comparado y sus concretas manifestaciones en el derecho chileno vigente, incluida la Empresa Individual de Responsabilidad Limitada -EIRL-, explicando en definitiva la incardinación y los efectos que genera la nueva figura de la sociedad de un solo socio en un sistema positivo inspirado, originariamente al menos, en la noción contractualista de la sociedad en general y en la concepción corporativa tradicional de la sociedad de capital en particular.The present investigation arises from the definitive recognition in Chile of the one man company phenomenon and, recently, of the Stock Company -SpA- with only one partner, in its original aspect. Its objective specifically points out to explore the real impact of this figure in the dogmatic structure of the Chilean law and specially of the company law, built from the concept of a company considered in the article 2053 of the Civil Code. What is being analyzed here is the one man company figure in compared law and its concrete declarations in the current Chilean law, including the Individual Limited Liability Corporation, explaining ultimately the incardination and the possible effects that can arise the one man company figure in a positive system, inspired originally at least, in the contractual sense of the company in general and the traditional corporative conception of the capital company particularly.

  1. Síndrome de Devic asociado con lupus eritematoso sistémico. Descripción de un caso

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    Juan Camilo Botero; Alejandro García; Juliana Hidalgo

    2007-01-01

    El síndrome de Devic es una las enfermedades desmielinizantes del sistema nervioso central, de etiología desconocida. Se relaciona mucho con el lupus eritematoso sistémico siendo una complicación rara y grave. Este síndrome se presenta como mielitis transversa de compromiso a nivel cervical y neuritis óptica. Se describe el caso de de una paciente de 32 años, que se presentó al servicio de urgencias por dolor en región torácica, pérdida de la fuerza muscular progresiva en los miembros inferio...

  2. Radiologically detectable musculoskeletal involvement in systemic lupus erythematosus; Afectacion musculoesquelitca con expresion radiologica en el lupus eritematoso sistemico

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    Jimenez, M. M.; Manjon, P.; Diaz de Bustamante, T.; Galindo, M.; Buj, M. J.; Cabezudo, J. [Hospital Doce de Octubre de Madrid (Spain)

    2000-07-01

    We show a wide spectrum of musculoskeletal involvement in systemic lupus erythematosus (SLE) that can be detected by radiological examination. We determined the indications of different imaging techniques in the diagnosis and follow-up of this disease. We reviewed the clinical and radiological histories of 37 patients diagnosed as having SLE on the basis of serological and musculoskeletal criteria. We assessed the personal data of each patient, the association of the disease with autoimmune processes, serology, treatment and radiological findings using plain X ray, ultrasound, computed tomography (CT) and magnetic resonance (MR). Of the 37 cases reviewed, only ten presented changes in one or more of the imaging studies performed. the most common radiological finding was symmetric poly arthritis located at different sites. Other signs included avascular necrosis (late and early), inflammation and tendon and/or ligament rupture, nonerosive deforming arthropathies , soft tissue calcifications and arthritis (staphylococcal and tuberculous). A direct correlation was established between the anticardiolipin antibody titer, steroid doses and avascular necrosis. In SLE, radiologically detectable osteoarticular lesions are uncommon. Symmetric polyarthritis is the earliest lesion and that occurring most frequently. Other signs do not appear as often, with the exception of osteonecrosis, which usually occurs late. It developed early and was unusually aggressive in two youths with elevated anticardiolipin antibody titers and substantial systemic involvement in our series. The contributions of ultrasound and MR in the assessment of musculoskeletal involvement in SLE are especially relevant in the study of inflammations and tendon rupture and in the management of avascular necrosis, respectively. (Author) 17 refs.

  3. Síndrome de Devic asociado con lupus eritematoso sistémico. Descripción de un caso

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    Juan Camilo Botero

    2007-12-01

    Full Text Available El síndrome de Devic es una las enfermedades desmielinizantes del sistema nervioso central, de etiología desconocida. Se relaciona mucho con el lupus eritematoso sistémico siendo una complicación rara y grave. Este síndrome se presenta como mielitis transversa de compromiso a nivel cervical y neuritis óptica. Se describe el caso de de una paciente de 32 años, que se presentó al servicio de urgencias por dolor en región torácica, pérdida de la fuerza muscular progresiva en los miembros inferiores, pérdida del control del esfínter urinario y disminución de la agudeza visual. También relató antecedentes de lupus eritematoso sistémico. Al examen físico se encontró atrofia y palidez del disco óptico derecho, disminución en la fuerza muscular 3/5 en miembros superiores e inferiores, alteración en la sensibilidad y propiocepción de extremidades inferiores. La resonancia magnética mostró hallazgos sugestivos de mielitis transversa de C2 a C6. En el laboratorio se encontraron anticuerpos anticardiolipina elevados y anticuerpos antinucleares: 1:320. Se manejó con esteroides, hubo notable mejoría en los síntomas y se le dio de alta al sexto día, con tratamiento ambulatorio. Los hallazgos al examen físico, laboratorio e imagenología permitieron hacer el diagnóstico de síndrome de Devic. Con base en la revisión bibliográfica, se concluye que este síndrome es poco frecuente; sin embargo, se debe tener en cuenta como posible diagnóstico en todo paciente con antecedentes de lupus eritematoso sistémico y síntomas compatibles.

  4. Factores de riesgo relacionados con lupus eritematoso sistémico en población mexicana Risk factors associated with systemic lupus erythematosus in Mexican population

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    Abraham Zonana-Nacach

    2002-06-01

    Full Text Available Objetivo. Evaluar los factores de riesgo asociados con el desarrollo de lupus eritematoso sistémico en población mexicana. Material y métodos. Estudio de casos y controles, efectuado en junio de 1996 en el Departamento de Reumatología del Hospital de Especialidades del Centro Médico Nacional Siglo XXI (HE CMN, del Instituto Mexicano del Seguro Social, de la Ciudad de México. Se estudiaron 130 pacientes (casos que presentaban cuatro o más criterios de clasificación de lupus eritematoso sistémico (LES y con una evolución de la enfermedad menor de cinco años. Los controles fueron pacientes hospitalizados por enfermedades agudas no autoinmunes. Fueron pareados 1:1 por edad y sexo; ambos grupos se evaluaron a través de una entrevista directa y la aplicación de un cuestionario estructurado. Se estudiaron los siguientes factores de riesgo: genéticos (historia familiar de LES o enfermedad de tejido conjuntivo, sociodemográficos (raza, lugar de residencia, educación, ingreso mensual; hormonales (anticonceptivos orales, terapia hormonal de remplazo y ginecobstétricos; ambientales (productos para el cabello, cohabitación con perros, infecciones, alergias. El análisis estadístico fue hecho con razón de momios (RM IC 95% y regresión logística. Resultados. El análisis estadístico multivariado mostró asociación con el antecedente familiar de LES (RM 4.2, IC 95% 1.17-15.2 u otra ETC (RM 2.6, IC 95% 1.15-4.5, uso de anticonceptivos orales por más de un año (RM 2.1, IC 95% 1.13-4.3, faringoamigdalitis de repetición (RM 2.1, IC 95% 1.18 - 3.6 y fármacos (RM 5.0, IC 95% 1.62 - 21.6. No hubo relación con factores socieconómicos, el uso de productos para el cabello, con asma o con antecedentes alérgicos. Conclusiones. Factores genéticos como el antecedente heredo-familiar de LES o enfermedad de tejido conjuntivo en familiares de primer grado continúan siendo factores importantes en el desarrollo de LES. Otros factores de riesgo

  5. Estudio de seguimiento de los niveles de vitamina d en pacientes con lupus eritematoso cutáneo y correlación con la severidad de la enfermedad

    OpenAIRE

    Cutillas Marco, Eugenia

    2014-01-01

    INTRODUCCIÓN: La fuente más importante de vitamina D es la exposición de la piel a la radiación ultravioleta. Se han encontrado niveles bajos de vitamina D en pacientes con enfermedades autoinmunes, incluyendo diabetes tipo I, artritis reumatoide, esclerosis múltiple y lupus eritematoso sistémico. El lupus eritematoso cutáneo (LEC) se exacerba por la exposición solar y no existen estudios sobre prevalencia del déficit de vitamina D en los pacientes con LEC. Asimismo, se ha encontrado rela...

  6. Factores de riesgo relacionados con lupus eritematoso sistémico en población mexicana

    Directory of Open Access Journals (Sweden)

    Zonana-Nacach Abraham

    2002-01-01

    Full Text Available Objetivo. Evaluar los factores de riesgo asociados con el desarrollo de lupus eritematoso sistémico en población mexicana. Material y métodos. Estudio de casos y controles, efectuado en junio de 1996 en el Departamento de Reumatología del Hospital de Especialidades del Centro Médico Nacional Siglo XXI (HE CMN, del Instituto Mexicano del Seguro Social, de la Ciudad de México. Se estudiaron 130 pacientes (casos que presentaban cuatro o más criterios de clasificación de lupus eritematoso sistémico (LES y con una evolución de la enfermedad menor de cinco años. Los controles fueron pacientes hospitalizados por enfermedades agudas no autoinmunes. Fueron pareados 1:1 por edad y sexo; ambos grupos se evaluaron a través de una entrevista directa y la aplicación de un cuestionario estructurado. Se estudiaron los siguientes factores de riesgo: genéticos (historia familiar de LES o enfermedad de tejido conjuntivo, sociodemográficos (raza, lugar de residencia, educación, ingreso mensual; hormonales (anticonceptivos orales, terapia hormonal de remplazo y ginecobstétricos; ambientales (productos para el cabello, cohabitación con perros, infecciones, alergias. El análisis estadístico fue hecho con razón de momios (RM IC 95% y regresión logística. Resultados. El análisis estadístico multivariado mostró asociación con el antecedente familiar de LES (RM 4.2, IC 95% 1.17-15.2 u otra ETC (RM 2.6, IC 95% 1.15-4.5, uso de anticonceptivos orales por más de un año (RM 2.1, IC 95% 1.13-4.3, faringoamigdalitis de repetición (RM 2.1, IC 95% 1.18 - 3.6 y fármacos (RM 5.0, IC 95% 1.62 - 21.6. No hubo relación con factores socieconómicos, el uso de productos para el cabello, con asma o con antecedentes alérgicos. Conclusiones. Factores genéticos como el antecedente heredo-familiar de LES o enfermedad de tejido conjuntivo en familiares de primer grado continúan siendo factores importantes en el desarrollo de LES. Otros factores de riesgo

  7. Prevalencia de dislipidemias en los pacientes con lupus eritematoso sistémico en el Hospital Clínico Regional de Concepción.

    Directory of Open Access Journals (Sweden)

    Michelle Vinet M.

    2011-12-01

    Full Text Available INTRODUCCIÓN: El lupus eritematoso sistémico es considerado un factor de riesgo cardiovascular. En estos pacientes es frecuente hallar dislipidemias. La terapia corticoesteroide favorece las alteraciones lipídicas. HIPÓTESIS: Los pacientes con lupus eritematoso sistémico presentan hipercolesterolemia, hipertrigliceridemia o ambos, en mayor proporción que la población general. OBJETIVO: Determinar la prevalencia de dislipidemias en los pacientes diagnosticados de lupus eritematoso sistémico y controlados en el policlínico de reumatología del Hospital Clínico Regional de Concepción. MATERIAL Y MÉTODO: Estudio descriptivo transversal en pacientes diagnosticados de lupus eritematoso sisté-mico, y que se han controlado durante el 2010 en el policlínico de reumatología. Las variables estudiadas fueron: sexo, edad, hipercolesterolemia, hipertrigliceridemia, dosis/ tiempo de uso de corticoides e hidroxicloroquina. RESULTADOS: Total de pacientes estudiados (n=154, 88,9% (n=137 mujeres, edad promedio 45,6 + 5 años, 40,9% (n=43 presenta hipertrigliceridemia; 55,2% (n=58 presenta hipercolesterolemia y 65,9% (n=100 presenta ambas alteraciones. Pacientes con evolución menor de 10 años: 50% (n=29 presenta hipercolesterolemia, 34,5% (n=20 presentaba hipertrigliceridemia; con 11-20 años de evolución: 56,25% (n=18 presenta hipercolesterolemia.; 43,75% (n=14 presenta hipertrigliceridemia Con evolución mayor a 20 años: 73,3% (n=11 presenta hipercolesterolemia; 60% (n=9 presentaba hipertrigliceridemia Usuarios de corticoides 89% (n=138 y de hidroxicloroquina 92,4% (n=142. DISCUSIÓN: La principal alteración es hipercolesterolemia. Pacientes con más años de evolución presentan mayor número de dislipidemias. La mayoría son usuarios de corticoides. Concluimos que la prevalencia de dislipidemias es más frecuente en pacientes con lupus eritematoso sistémico que la población general. Mientras más años de evolución, se aprecia mayor

  8. Endoftalmitis endógena por Nocardia asteroides en un paciente con lupus eritematoso sistémico Endogenous Nocardia asteroides endophthalmitis in a patient with systemic lupus erythematosus

    OpenAIRE

    David E. Pelayes; Daniel Colombero; Joaquín M. Gioino; Jorge O. Zárate; Gustavo Piantoni

    2004-01-01

    Se describe un caso de endoftalmitis endógena por nocardia en un varón de 32 años con diagnóstico de lupus eritematoso sistémico. El paciente desarrolló compromiso pulmonar y ocular luego de meses de tratamiento con corticoides y ciclofosfamida. La infección intraocular, de rápida evolución a fístula escleral, recibió tratamiento con vitrectomía, lensectomía y terapia antibacteriana intravítrea y endovenosa. Se aislaron colonias de Nocardia asteroides a partir de material vítreo y aspirado br...

  9. Endoftalmitis endógena por Nocardia asteroides en un paciente con lupus eritematoso sistémico Endogenous Nocardia asteroides endophthalmitis in a patient with systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    David E. Pelayes

    2004-04-01

    Full Text Available Se describe un caso de endoftalmitis endógena por nocardia en un varón de 32 años con diagnóstico de lupus eritematoso sistémico. El paciente desarrolló compromiso pulmonar y ocular luego de meses de tratamiento con corticoides y ciclofosfamida. La infección intraocular, de rápida evolución a fístula escleral, recibió tratamiento con vitrectomía, lensectomía y terapia antibacteriana intravítrea y endovenosa. Se aislaron colonias de Nocardia asteroides a partir de material vítreo y aspirado bronquioloalveolar. El ojo afectado evolucionó a ptisis bulbi y fue posteriormente eviscerado, y se realizó el estudio histopatológico.We report a case of endogenous nocardial endophthalmitis in a 32-year-old man with systemic lupus erythematosus. The patient developed pulmonary and ocular disease while on systemic corticosteroid and cyclophosphamide treatment. The intraocular infection progressed to a scleral fistula, and was treatead with pars plana vitrectomy, lensectomy, intravitreous and intravenous antibacterial therapy. The diagnosis of Nocardia asteroides was made by isolation and growth of colonies from samples of a vitreous specimen and bronchioloalveolar aspirates. The eye became phthisical, it was eviscerated, and histopathogical examination was carried out.

  10. Miocardiopatía Dilatada en paciente con Lupus Eritematoso Sisté- mico. Reporte de un caso.

    Directory of Open Access Journals (Sweden)

    Enzo Serri S

    2011-12-01

    Full Text Available INTRODUCCIÓN: El Lupus Eritematoso Sistémico (LES es una enfermedad autoinmune de etiología desconocida, cuyo cuadro clínico incluye diversas manifestaciones cardiovasculares, las que se pueden presentar entre el 50 y 60% de los pacientes. La miocarditis es infrecuente (10%, pudiendo evolucionar tanto a miocardiopatía dilatada como a la mejoría. PRESENTACIÓN DEL CASO: Mujer de 40 años con antecedentes de LES diagnosticado el año 2008 y hospitalización anterior por cuadro de síndrome nefrótico, consulta en la urgencia del Hospital Guillermo Grant Benavente el por cuadro clínico de dos semanas de evolución caracterizado por disnea de mínimo esfuerzo, oliguria y edema continuo de extremidades inferiores. Destacan dentro de sus exámenes de ingreso: creatinina de 1,8 mg/dl, PCR 5; radiografía de tórax muestra cardiomegalia. Se hospitaliza en servicio de medicina interna para manejo. Evoluciona con mayor disnea y dolor torácico, por lo que se realiza ecocardiograma que revela miocardiopatía dilatada y disfunción sistólica severa. Se añade al tratamiento esteroidal previo, furosemida, carvedilol, enalapril y bolos de metilprednisolona y ciclofosfamida. Paciente evoluciona satisfactoriamente, con disminución de la disnea y leve edema de las extremidades inferiores, aunque permanece con valores de creatinina alterados. Luego de un mes es dada de alta. DISCUSIÓN: Señalamos que la miocardiopatía dilatada es una complicación infrecuente del LES, y si bien es cierto es la principal explicación para el cuadro clínico de insuficiencia cardiaca en esta paciente, no explica por si sola la sintomatología, considerando el antecedente de compromiso renal.

  11. Calidad de vida relacionada con la salud, factores psicológicos y fisiopatológicos en pacientes con diagnóstico de Lupus Eritematoso Sistémico - LES

    OpenAIRE

    Karem Ariza; Paula Isaza; Ana Milena Gaviria; Japcy Margarita Quiceno; Stefano Vinaccia; Liliana Alvarán; Luis Fernando Pinto; Carlos Jaime Velásquez; Javier Darío Márquez

    2010-01-01

    El objetivo de este estudio fue analizar, por un lado, los niveles de ansiedad, depresión, apoyo social, índice de actividad lúpica, fibromialgia, daño orgánico y renal, tiempo de diagnóstico de la enfermedad y factores sociodemográficos en 78 pacientes con diagnóstico de Lupus Eritematoso Sistémico; y analizar el efecto de estas variables sobre la calidad de vida relacionada con la salud. Se emplearon como instrumentos: el cuestionario de Salud MOS SF-36, la Escala Hospitalaria de Ansiedad y...

  12. Co-detección de Patógenos Periodontales en Pacientes Chilenos con Periodontitis Crónica Co-detection of Periodontal Pathogens in Chilean Patients with Chronic Periodontitis

    Directory of Open Access Journals (Sweden)

    C Mujica Troncoso

    2010-12-01

    Full Text Available Las enfermedades periodontales asociadas a la placa dental son un importante problema de salud pública. La etiología de estas patologías es de origen multifactorial e involucra factores del hospedero, medio ambiente y de carácter infeccioso asociados a bacterias embebidas en la placa dental. Las principales bacterias asociadas a la periodontitis crónica son Porphyromonas gingivalis, Treponema denticola y Tannerella forsythia, mientras que Aggregatibacter actinomycetemcomitans se ha asociado principalmente a la periodontitis agresiva. Otro microorganismo clave en el desarrollo de la enfermedad es Fusobacterium nucleatum, el cual tiene la capacidad de co-agregarse con los patógenos periodontales y así facilitar su colonización. Para demostrar la prevalencia de estas bacterias, la co-detección y la asociación entre pacientes chilenos fumadores y no fumadores, se analizaron 67 muestras mediante PCR convencional. Los resultados mostraron que un 90% de las muestras fueron positivas para F. nucleatum, siendo la bacteria más detectada. Al analizar la co-detección entre las distintas bacterias se observa que F nucleatum está presente en más de un 80% de los casos cuando se detecta cualquiera de las cuatro bacterias restantes, mientas que A. actinomycetemcomitans se detecta en no más de un 20% al amplificar cualquiera de las bacterias restantes. Por otra parte, los resultados por género indican que existen diferencias significativas en la detección de T. forsythia, F. nucleatum y A. actinomycetemcomitans. Al considerar el factor de tabaquismo se observó que ninguna de las muestras de pacientes fumadores resultó ser positiva para A. actinomycetemcomitans.Periodontal disease associated with dental plaque is a major public health problem. The etiology of these disorders is multifactorial involved seeing host factors, environmental factors and infectious nature associated with the presence of bacteria belonging to the plaque. The main

  13. Violencia y videojuegos en adolescentes chilenos y mexicanos.

    Directory of Open Access Journals (Sweden)

    Patricia Martínez Lanz

    2010-12-01

    Full Text Available El objetivo de la presente investigación fue analizar la relación entre los niveles de violencia y el uso de videojuegos en adolescentes mexicanos y chilenos. Se utilizó una muestra no probabilística de 100 adolescentes, 50 de nacionalidad Mexicana y 50 de nacionalidad Chilena. Con un rango de edad de 12 a 18 años. El instrumento tuvo una serie de preguntas cerradas acerca de la conducta cotidiana del uso de videojuegos, para evaluar la violencia se aplicó un instrumento de 15 reactivos que miden las siguientes dimensiones: agresión verbal, agresión física, humillación y respeto. En cuanto a los niveles de agresión se diseñó una escala de 13 reactivos, tipo Likert con cuatro opciones de respuesta que van de Nunca a Siempre. Los resultados mostraron relaciones significativas entre los niveles de violencia y el uso de videojuegos; además, se encontraron algunas diferencias en éstas variables entre las dos muestras (México y Chile, en donde los adolescentes mexicanos mostraron niveles más altos en violencia y agresión en comparación con los chilenos.

  14. Calidad de vida relacionada con la salud, factores psicológicos y fisiopatológicos en pacientes con diagnóstico de Lupus Eritematoso Sistémico - LES

    Directory of Open Access Journals (Sweden)

    Karem Ariza

    2010-01-01

    Full Text Available El objetivo de este estudio fue analizar, por un lado, los niveles de ansiedad, depresión, apoyo social, índice de actividad lúpica, fibromialgia, daño orgánico y renal, tiempo de diagnóstico de la enfermedad y factores sociodemográficos en 78 pacientes con diagnóstico de Lupus Eritematoso Sistémico; y analizar el efecto de estas variables sobre la calidad de vida relacionada con la salud. Se emplearon como instrumentos: el cuestionario de Salud MOS SF-36, la Escala Hospitalaria de Ansiedad y Depresión HAD, el cuestionario de Apoyo Social Funcional DUKE-UjNTK, el índice de Actividad Lúpica SLEDAI y el índice de Daño Orgánico SLICC-ACR; y se consideró además el diagnóstico médico de Fibromialgia y de Nefropatía. Los resultados señalaron que factores fisiopatológicos (actividad lúpica y daño orgánico, psicológicos (ansiedad-depresión y sociodemográficos (ocupación y estado civil y la interacción entre estos afectan la calidad de vida a nivel mental más que físico en los pacientes con lupus.

  15. Manifestaciones cutáneas de lupus eritematoso sistémico temprano y correlación con la actividad sistémica = Cutaneous manifestations of early systemic lupus erythematosus and correlation with systemic activity

    OpenAIRE

    Velásquez Franco, Carlos Jaime; Anaya Prada, Andrés Ricardo; Rodríguez Padilla, Libia María; Vargas Grajales, Francisco Iván; Ramirez Gómez, Luis Alberto

    2011-01-01

    Las manifestaciones cutáneas del lupus eritematoso sistémico (LES) son heterogéneas (espe­cíficas e inespecíficas). Poco se sabe acerca de la relación entre estas manifestaciones y la actividad clínica e inmunológica de la enfermedad en sus etapas iniciales. Se llevó a cabo un estudio de corte transversal en 34 pacientes con LES temprano. Se encontró una asociación significativa entre alopecia e hipocomplementemia C3 (p = 0,021), hipocomplementemia C4 (p < 0,001) y anti-Sm (p = 0,011); entre ...

  16. Subpoblaciones de linfocitos B y su expresión de CD1d en pacientes con lupus eritematoso sistémico

    Directory of Open Access Journals (Sweden)

    Claudia Carolina Sánchez Parra

    2013-12-01

    Full Text Available Resumen Introducción: Los linfocitos B (LB se consideran el centro de la desregulación inmune en pacientes con lupus eritematoso sistémico (LES, principalmente, por su producción de autoanticuerpos. Recientemente, se demostró la existencia de LB, incluidos en los B transicionales, con capacidad reguladora (Breg y fenotipo CD19+CD24hiCD38hi. En humanos se demostró la importancia de CD80 y CD86 en su función reguladora. El papel de CD1d aún no ha sido evaluado. Objetivo: Evaluar la frecuencia de LB maduros, memoria y transicionales, en controles y pacientes con LES, además de la expresión de CD1d y correlacionarla con la actividad de la enfermedad medida por SLEDAI (Systemic Lupus Erythematosus Disease Activity Index. Materiales y métodos: Se evaluó por citometría de flujo la frecuencia de subpoblaciones de LB basados en la expresión de CD19, CD24 y CD38, además de CD1d, en controles con otras enfermedades autoinmunes (OEA, individuos sanos y pacientes con LES, y se correlacionó con SLEDAI. Resultados: Se evidenció una disminución significativa en el porcentaje de LB de memoria en pacientes LES y OEA, sin alteraciones en las subpoblaciones de LB maduros y transicionales. La expresión de CD1d no evidenció diferencias significativas en ninguna de las subpoblaciones ni se correlacionó con SLEDAI. Conclusión: La disminución de la subpoblación de memoria fue previamente descrita en LES y se ha asociado a algunos tipos de tratamiento. Aunque CD1d se ha asociado a la función de Breg en murinos, no hubo diferencias significativas en su expresión en las subpoblaciones y queda por clarificar su papel en la función de las Breg humanas.

  17. Lupus Nephritis

    Science.gov (United States)

    ... Disease Organizations​​ . (PDF, 345 KB)​​​​​ Alternate Language URL Lupus Nephritis Page Content On this page: What is lupus ... Nutrition Points to Remember Clinical Trials What is lupus nephritis? Lupus nephritis is kidney inflammation caused by systemic ...

  18. Lupus and Kidney Disease (Lupus Nephritis)

    Science.gov (United States)

    ... NKF Newsroom Contact Us You are here Home » Lupus and Kidney Disease (Lupus Nephritis) Lupus is a short name for a ... affects only your skin. A Personal Look at Lupus Nephritis What causes lupus? No one knows what ...

  19. Neurological Sequelae of Lupus

    Science.gov (United States)

    ... Find People About NINDS NINDS Neurological Sequelae Of Lupus Information Page Synonym(s): Lupus - Neurological Sequelae, Systemic Lupus ... resources from MedlinePlus What are Neurological Sequelae Of Lupus? Lupus (also called systemic lupus erythematosus ) is a ...

  20. Manifestaciones cutáneas de lupus eritematoso sistémico temprano y correlación con la actividad sistémica = Cutaneous manifestations of early systemic lupus erythematosus and correlation with systemic activity

    Directory of Open Access Journals (Sweden)

    Velásquez Franco, Carlos Jaime

    2011-12-01

    Full Text Available Las manifestaciones cutáneas del lupus eritematoso sistémico (LES son heterogéneas (espe­cíficas e inespecíficas. Poco se sabe acerca de la relación entre estas manifestaciones y la actividad clínica e inmunológica de la enfermedad en sus etapas iniciales. Se llevó a cabo un estudio de corte transversal en 34 pacientes con LES temprano. Se encontró una asociación significativa entre alopecia e hipocomplementemia C3 (p = 0,021, hipocomplementemia C4 (p < 0,001 y anti-Sm (p = 0,011; entre eritema malar y anti-Ro (p = 0,037 y anti-La (p = 0,037; entre fotosensibilidad y anti-RNP (p = 0,037. Se observó una tendencia a la asociación entre úlceras orales e hipocomplementemia C4 (p = 0,064. No hubo asociación entre las ma­nifestaciones cutáneas y la presencia de anti-ADN de doble cadena (anti-ds ADN, anticuerpos anticardiolipinas, anticoagulante lúpico, VDRL falso positivo, leucopenia, trombocitopenia, hipergammaglobulinemia, elevación de la velocidad de sedimentación globular o SLEDAI. Se resalta la importancia de la relación entre las manifestaciones cutáneas inespecíficas de LES (alopecia y fotosensibilidad y la actividad sistémica en pacientes con enfermedad temprana y la clara asociación de estas con hipocomplementemia, un marcador importante de actividad inmunológica.

  1. La reforma del sistema electoral chileno

    OpenAIRE

    Mariela Rubano Lapasta

    2007-01-01

    La modificación del sistema electoral público chileno se ha transformado nuevamente en tema de debate público, después de la Reforma Constitucional de 2005. El Gobierno ha propuesto reformar el sistema electoral, sustituirlo por otro que permita a las minorías tener representación en el Congreso. Se abordan brevemente los sistemas electorales en el derecho comparado, en especial el caso chileno, evaluando las ventajas y desventajas del sistema electoral nacional. Se propone ...

  2. Target Awareness: Lupus

    Science.gov (United States)

    ... Target Awareness: Lupus Jan. 15, 2009 Target Awareness: Lupus Target Awareness: Lupus provides a brief overview of ... Email Print Tags for this Story treatments symptoms Lupus FAQ What is lupus? What are the common ...

  3. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Target Awareness: Lupus Jan. 15, 2009 Target Awareness: Lupus Target Awareness: Lupus provides a brief overview of ... Email Print Tags for this Story treatments symptoms Lupus FAQ What is lupus? What are the common ...

  4. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Lupus Q&A with Dr. Jim Oates - Cardiac Issues and Lupus Q&A with Monica Richey - Preventive ... 15 Questions - Fatigue and Lupus 15 Questions - Musculoskeletal Issues and Lupus 15 Questions - Cancer and Lupus 15 ...

  5. Estilos de comportamiento emocional adolescente en el marco de la personalidad eficaz en contextos educativos chilenos

    OpenAIRE

    Muñoz Rojo, María Isabel

    2013-01-01

    Previa adaptación chilena del cuestionario abreviado de comportamento emocional para adolescentes con todas las características psicométricas requeridas se obtiene ocho perfiles tipológicos modales en contextos adolescentes chilenos en función de cuatro dimensiones: Tendencia agrsesiva, rechazo social, procupación social y expresión afectiva. La dimensión tendencia agresiva divide a los ocho tipos en dos grupos homogéneos: cuatro con tendencia agresiva por encima de la media y cuatro por deba...

  6. La relación del autoconcepto y de los valores con la participación social y el comportamiento sexual de riesgo, en jóvenes universitarios chilenos

    OpenAIRE

    Vidal Pollarolo, Paulina

    2015-01-01

    Resumen Tesis doctoral: “La relación del autoconcepto y de los valores con la participación social y el comportamiento sexual de riesgo, en jóvenes universitarios chilenos” Tesista: Paulina Vidal Director de Tesis: Dr. Manuel Martí- Vilar 1.- Marco teórico: Se recogen los postulados acerca del autoconcepto, como aspecto modular de la identidad y su relación con los estilos de vida saludables. Se discuten los resultados sobre la influencia que tendría el género en el autoconcepto...

  7. Propiedades psicométricas de tres escalas de evaluación del trastorno por déficit de atención con hiperactividad en escolares chilenos Psychometric properties of three rating scales for attention deficit hyperactivity disorder in Chilean students

    Directory of Open Access Journals (Sweden)

    Alfonso Urzúa

    2010-03-01

    Full Text Available OBJETIVO: Evaluar en escolares chilenos la fiabilidad y la validez de tres escalas que miden el trastorno de déficit de atención con hiperactividad (TDAH: el inventario para déficit de atención (IDDA, la escala de evaluación del déficit de atención con hiperactividad (EDAH y la adaptación española de la escala para la gradación del déficit de atención con hiperactividad IV (EGDAH IV. MÉTODO: Estudio instrumental con los tutores (n = 612 y los profesores (n = 82 de una muestra intencional de 640 niños y niñas de 6 a 11 años de edad, estudiantes de establecimientos municipales públicos (n = 228; 35,6% del total; subvencionados (n = 200; 31,3% y privados (n = 212; 33,1% de la ciudad de Antofagasta, Chile. La validez de convergencia de los instrumentos de medición del TDAH se determinó mediante las pruebas de Stroop y de Wechsler. RESULTADOS: Las tres escalas evaluadas presentan niveles satisfactorios de consistencia interna (coeficiente alfa de Cronbach de 0,88 a 0,97 en las escalas y de 0,76 a 0,97 en las dimensiones y una estructura factorial acorde a la teórica en la mayoría de las dimensiones evaluadas, aunque solo la EGDAH IV con los tutores y los profesores, y el IDDA con los profesores mostraron índices de ajuste comparativo y de ajuste relativo superiores a 0,90. Se encontraron diferencias significativas según la edad, el sexo y el tipo de informante (tutor o profesor. CONCLUSIÓN: El IDDA y la EGDAH IV cumplieron favorablemente con todos los criterios de fiabilidad y validez, por lo que se pueden aplicar para el tamizaje y el diagnóstico en la población chilena. La escala EGDAH IV presentó las mejores propiedades psicométricas por su confiabilidad y validez.OBJECTIVE: To assess, among Chilean students, the reliability and validity of three scales that measure attention deficit hyperactivity disorder (ADHD: the ADHD Rating Scale-IV (ADHD-IV; the scale for evaluating attention deficit disorder with hyperactivity

  8. Eugenesia: Ciencia y religión. Una aproximación al caso chileno

    Directory of Open Access Journals (Sweden)

    Marcelo Sánchez Delgado

    2015-03-01

    Full Text Available El trabajo tiene como objetivo investigar las relaciones de continuidad y tensión entre el proyecto moderno, el pensamiento religioso y la propuesta eugénica en el contexto chileno. El trabajo inicia con una reflexión general sobre las relaciones entre eugenesia y religión en el contexto moderno, para luego abordar fuentes primarias que incluyen textos de médicos y abogados chilenos de la primera mitad del siglo XX. El resultado fundamental del trabajo demuestra que el debate del pensamiento eugénico en el contexto nacional no estuvo ajeno a las fuerzas religiosas, utópicas y mistificantes que tendían a ver la eugenesia como la religión del futuro y como un pensamiento de vanguardia, alternativo y crítico del cristianismo. Por otra parte, destaca también como resultado del trabajo, una aproximación y revalorización de las relaciones entre catolicismo y eugenesia en el contexto chileno.

  9. Estudio sobre la afectación auditiva en pacientes con lupus eritematoso sistémico

    OpenAIRE

    Pérez, A.; Pertierra, M.A.; Padilla, M.; Monje, E.; Reyes, R.; Ortiz, M; Zaragoza, L.; González, M.

    2004-01-01

    Es bien conocido que las enfermedades inmunológicas pueden cursar una afectación multisistémica; dentro de dichas afectaciones el área O.R.L. no está exenta de afectación. Habiéndose relacionado desde hace poco tiempo con la posibilidad de la existencia de hipoacusias asociadas, que se pueden presentar en cualquier momento de la enfermedad. Nuestro estudio está basado en 74 pacientes diagnosticado de L.E.S. procedentes de la consulta de Medicina Interna del Hospital Carlos Haya de Málag...

  10. Características hematológicas y patológicas de cerdos inoculados experimentalmente con el aislado chileno del virus síndrome respiratorio y reproductivo porcino Haematological and pathological findings of pigs experimentally inoculated with a Chilean isolate of porcine reproductive and respiratory syndrome virus

    Directory of Open Access Journals (Sweden)

    E Ramírez

    2006-01-01

    Full Text Available El presente trabajo se planteó con el fin de caracterizar las manifestaciones hematológicas y lesiones de cerdos inoculados con el aislado chileno del vPRRS. Se utilizaron 12 cerdos de 3 semanas de edad divididos en 4 grupos de 3 animales cada uno, uno de los cuales correspondió al grupo control que fueron sacrificados a los 0 días postinoculación (dpi, y los 3 grupos restantes a los cerdos inoculados que fueron sacrificados a los 7, 14 y 21 dpi. Durante cada muestreo se recolectó sangre para hemogramas y al sacrificio se determinaron las lesiones macroscópicas y se tomaron muestras para frotis de médula ósea y para histopatología. Los resultados de este estudio revelaron alteraciones hematológicas caracterizadas por descenso del volumen globular (PThe aims of this study were to characterize the haematological and bone marrow changes, gross and microscopic lesions of pigs experimentally inoculated with the Chilean isolate of porcine reproductive and respiratory syndrome virus. Twelve 3-week-old pigs were divided in 4 groups of 3, one of which corresponded to the negative control group sacrificed at 0 days post-inoculation (dpi, and the 3 remaining groups corresponded to the inoculated pigs sacrificed at 7, 14 and 21 dpi. For each sampling period blood was collected for complete haemograme and at the necropsy time gross lesions were registered and samples for both bone marrow smears and histopathology were taken. The results of this study revealed haematological alterations characterized by a significant reduction (P<0.05 in the haematocrit and a significant increase (P<0.05 in the total leukocyte count associated with an increase in the monocytes and baciliforms. The bone marrow did not show significant variations in the ratio of myeloid to erythroid cells (P0.05. At the same time, the gross lesions were mild and mainly characterized by the presence of conjunctivitis, periocular edema and a slight increase in the size of the lymph

  11. Life with Lupus

    Science.gov (United States)

    ... Snowboarding, Skating Crushes What's a Booger? Life With Lupus KidsHealth > For Kids > Life With Lupus Print A ... the symptoms often go away. continue What Causes Lupus? No one really knows what causes lupus, but ...

  12. Living Well with Lupus

    Science.gov (United States)

    ... Can lupus affect my friendships? Can lupus cause depression? How will lupus affect my family? How does lupus affect memory? 1 2 3 Next Share This Page Facebook Twitter Email Print Popular Topics living well nutrition ...

  13. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Questions - Gastrointestinal Issues with Lupus 15 Questions - Balancing Family, Friends, Activities and Lupus 15 Questions - Disability: Working Your Way Through the System 15 Questions - Back to School with Lupus 15 Questions - Oral Issues with Lupus ...

  14. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Issues with Lupus 15 Questions - How Lupus Can Affect the Eyes 15 Questions - The Mysterious Aspects of ... what makes lupus so different from many other diseases and why lupus is a cruel mystery. Video | ...

  15. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Have Lupus I Have Lupus I'm a Friend or Family Member I'm a Caregiver Help & ... Gastrointestinal Issues with Lupus 15 Questions - Balancing Family, Friends, Activities and Lupus 15 Questions - Disability: Working Your ...

  16. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... lupus research program aggressively seeks to advance the science and medicine of lupus and to improve the quality of life for all people affected by lupus. ... Lupus.org Get Answers Find ...

  17. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Cancer and Lupus 15 Questions - Lupus and Overlap Disease/Syndromes 15 Questions - Cognitive issues and headaches associated ... what makes lupus so different from many other diseases and why lupus is a cruel mystery. Video | ...

  18. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... issues and headaches associated with lupus 15 Questions – Skin Issues and Hair Loss with Lupus 15 Questions - ... the Eyes 15 Questions - The Mysterious Aspects of Skin Lupus 15 Questions - Men and Lupus 15 Questions - ...

  19. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Dr. Ronenn Roubenoff - Nutrition and Lupus 15 Questions - Depression and Lupus 15 Questions - Fatigue and Lupus 15 ... lupus Health Insurance Health Insurance Options Medicare Medicaid Life Insurance Employment, Disability and Legal Issues Social Security ...

  20. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... 15 Questions - Understanding Lupus 15 Questions - Spotlight on Clinical Trials 15 Questions - Kidney Issues and Lupus 15 Questions – ... 15 Questions - Cardiovascular Issues with Lupus 15 Questions - Clinical Trials 15 Questions - Gastrointestinal Issues with Lupus 15 Questions - ...

  1. Systemic lupus erythematosus

    Science.gov (United States)

    Disseminated lupus erythematosus; SLE; Lupus; Lupus erythematosus ... have only skin symptoms. This is called discoid lupus. ... To be diagnosed with lupus, you must have 4 out of 11 common signs of the disease. Nearly all people with lupus have a positive ...

  2. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... and Stress Q&A with Dr. Ronenn Roubenoff - Nutrition and Lupus 15 Questions - Depression and Lupus 15 Questions - Fatigue and Lupus 15 Questions - Musculoskeletal Issues and Lupus 15 Questions - Cancer and Lupus 15 Questions - Lupus and Overlap Disease/ ...

  3. Lupus nephritis

    Science.gov (United States)

    ... American College of Rheumatology Guidelines for Screening, Case Definition, Treatment and Management of Lupus Nephritis. Arthritis Care ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  4. Gestación exitosa después de exposición inadvertida a ciclofosfamida durante el primer trimestre en una paciente con lupus activo. Reporte de caso = Successful pregnancy after inadvertent exposure to cyclophosphamide in the first trimester in a patient with active lupus. Case report

    OpenAIRE

    Restrepo Escobar, Mauricio

    2011-01-01

    La ciclofosfamida se debe evitar durante el embarazo por sus efectos teratogénicos reconocidos. Los embriones o fetos de madres que requieren el uso de ciclofosfamida, o que se exponen inadvertidamente a la misma, tienen usualmente un desenlace adverso. En muy raras ocasiones se han informado gestaciones exitosas a pesar del uso de este medicamento durante el embarazo. Presentamos un nuevo caso de gestación exitosa en una mujer con lupus activo renal y neurosiquiátrico quien tuvo exposición a...

  5. Gestación exitosa después de exposición inadvertida a ciclofosfamida durante el primer trimestre en una paciente con lupus activo. Reporte de caso = Successful pregnancy after inadvertent exposure to cyclophosphamide in the first trimester in a patient with active lupus. Case report

    Directory of Open Access Journals (Sweden)

    Restrepo Escobar, Mauricio

    2011-09-01

    Full Text Available La ciclofosfamida se debe evitar durante el embarazo por sus efectos teratogénicos reconocidos. Los embriones o fetos de madres que requieren el uso de ciclofosfamida, o que se exponen inadvertidamente a la misma, tienen usualmente un desenlace adverso. En muy raras ocasiones se han informado gestaciones exitosas a pesar del uso de este medicamento durante el embarazo. Presentamos un nuevo caso de gestación exitosa en una mujer con lupus activo renal y neurosiquiátrico quien tuvo exposición a la ciclofosfamida durante el primer trimestre de su gestación.

  6. LA JUSTICIA AMBIENTAL EN EL ORDENAMIENTO JURÍDICO AMBIENTAL CHILENO

    OpenAIRE

    Dominique Hervé Espejo; Sebastián Rebolledo

    2013-01-01

    El presente trabajo desarrolla la noción de justicia ambiental y sus elementos configurativos. En virtud de aquel marco se revisan dos instituciones jurídicas del ordenamiento jurídico ambiental chileno, con el objeto de evaluar si en las normas que las consagran se incorporan o reflejan dichos elementos. Los instrumentos jurídicos analizados son la participación ciudadana en el Sistema de Evaluación de Impacto Ambiental y la Evaluación Ambiental Estratégica.

  7. Aporte de vitaminas y minerales por grupo de alimentos en estudiantes universitarios chilenos

    OpenAIRE

    Samuel Durán Agüero; Susanne Reyes García; María Cristina Gaete

    2013-01-01

    Introducción: La etapa universitaria es un proceso en el cual las personas pasan por periodos prolongados de inactividad física y horarios irregulares de comidas, lo que conlleva al incremento en el consumo de alimentos procesados y de comida rápida. Objetivo: Fue determinar el aporte vitaminas y minerales por grupo de alimentos en la alimentación de estudiantes universitarios. Métodos: Se trabajó con una muestra de 654 estudiantes universitarios chilenos (18-24 años, 54% mujeres), a quienes ...

  8. Estructura factorial y consistencia interna del inventario de liderazgo distribuido (DLI) en docentes chilenos

    OpenAIRE

    López Alfaro, Pablo; Gallegos Araya, Verónica

    2015-01-01

    Este artículo presenta el análisis de la estructura factorial y consistencia interna del instrumento “The Distributed Leadership Inventory (DLI)” en docentes primarios chilenos. Participaron voluntariamente 511 educadores (379 mujeres, 132 hombres) en ejercicio, pertenecientes a las siguientes regiones: Metropolitana, Segunda, Quinta, Octava y Novena, en el periodo marzo-septiembre del año 2014. Se realizó el análisis factorial exploratorio y el análisis factorial confirmatorio con ecuaciones...

  9. Diagnostico institucional del sistema de pensiones chileno y propuesta de recomendaciones

    OpenAIRE

    Fernando Grafe

    2006-01-01

    Este informe presenta la reforma y la transición del sistema previsional chileno. Incluye un análisis del impacto sobre las cuentas fiscales y la cobertura del sistema civil y el problema de las densidades de cotización. El Decreto Ley n.º 3500, de 1980, con entrada en vigor el 1 de enero de 1983, también introdujo una profunda transformación en el diseño institucional de los distintos esquemas de pensiones en Chile. El documento detalla el diseño institucional. Además, se comentan las disfun...

  10. Derecho a la educación. Su contenido esencial en el derecho chileno

    Directory of Open Access Journals (Sweden)

    Juan Carlos Flores Rivas

    2014-01-01

    Full Text Available El artículo analiza los elementos esenciales del derecho a la educación en el Derecho Chileno, situando al educando en el centro de todo el proceso educacional. De este modo, se estudia el derecho y el deber de los padres a educar a sus hijos, eligiendo el establecimiento educacional que estimen conveniente para el mejor desarrollo de sus habilidades. Asimismo, se analiza el deber del Estado de diseñar un régimen gratuito para la educación obligatoria, con la finalidad de permitir el acceso a los niveles educativos obligatorios de toda la población.

  11. Are There Various Forms of Lupus?

    Science.gov (United States)

    ... lupus Understanding lupus Are there various forms of lupus? Systemic Lupus Erythematosus Systemic lupus is the most common form ... and tissues at “ Lupus and the Body ”. Cutaneous Lupus Erythematosus This form of lupus is limited to ...

  12. UN ANÁLISIS SINCRÓNICO DEL VOSEO VERBAL CHILENO Y RIOPLATENSE

    Directory of Open Access Journals (Sweden)

    Julia M Baquero Velásquez

    2014-07-01

    Full Text Available Se cuestiona el enfoque tradicional de los voseos chileno y rioplatense, el cual deriva ambos de las formas verbales correspondientes a vosotros, usando por lo menos seis reglas distintas, incluidos tres procesos de monoptongación que carecen de toda motivación fonológica. En contrapartida, se argumenta que las formas verbales de dichos voseos no se derivan sincrónicamente de las formas de la segunda persona plural, sino de representaciones subyacentes coincidentes con las de la segunda persona singular no honorífica. Con ello, la teoría requiere del uso de una sola regla especial para el voseo chileno, la cual permite derivar todas las formas verbales del caso, en conjunción con otras reglas que tienen justificación independiente en la lengua. La propuesta se enmarca dentro del formalismo de la fonología generativa clásica. Todas las formas de ambos voseos han sido documentadas en el corpus CORDE de la RAE, el uso de internautas y las intuiciones lingüísticas de los autores.

  13. Myocarditis in a 72-year-old woman with late onset systemic lupus erythematous Miocarditis en una mujer de 72 años con lupus eritematoso sistémico de inicio tardío

    OpenAIRE

    V.M. Santos; L. R. Cruz; A. C. R. Holanda; N. P. Machado

    2012-01-01

    A 72-year-old female with late onset systemic lupus erythematosus (SLE) was admitted with chest pain and dyspnoea, and was submitted to investigation by echocardiogram, cardiovascular magnetic resonance (CMR) and serology panel. Morphological and functional studies of the heart revealed conspicuous inflammatory signs and moderate effusion compatible with myocarditis and pericarditis. Myocarditis is an uncommon manifestation of SLE. The additional burden posed by myocarditis in the management ...

  14. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Our national lupus research program aggressively seeks to advance the science and medicine of lupus and to improve the quality of life for all people affected by lupus. Share This Page Facebook Twitter Email Print Tags for this Story treatments symptoms Lupus FAQ What is lupus? What are ...

  15. Capacidad predictiva de la autoeficacia académica sobre las dimensiones del autoconcepto en una muestra de adolescentes chilenos

    OpenAIRE

    García-Fernández, J.M.; Díaz-Herrero, A. (Ángela); Inglés, C.J. (Cándido J.); Torregrosa, M.S. (María Soledad); Lagos-San-Martín, N. (Nelly); Gonzálvez, C. (Carolina)

    2016-01-01

    El objetivo de este estudio fue analizar la capacidad predictiva de la autoefi cacia académica sobre las dimensiones del autoconcepto en una muestra de 860 estudiantes chilenos. El análisis de regresión logística reveló que la autoefi cacia académica fue un predictor positivo y signifi cativo de las escalas académicas (Matemáticas, Verbal y Académica General), no académicas (Habilidades Físicas, Apariencia Física, Relaciones con el Sexo Opuesto, Relaciones con el Mi...

  16. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... for Children and Teens How to Help: A Communication Tool for Caregivers and Loved Ones with Lupus ... Reproduction and Contraception Health with Lupus 15 Questions - Men and Lupus 15 Questions - Nervous System Issues 15 ...

  17. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... for Applications Lupus Achievements and Advances Lupus Science & Medicine™ Local Chapters About Us What We Do Who ... program aggressively seeks to advance the science and medicine of lupus and to improve the quality of ...

  18. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... lupus Health Insurance Health Insurance Options Medicare Medicaid Life Insurance Employment, Disability and Legal Issues Social Security ... of lupus and to improve the quality of life for all people affected by lupus. Share This ...

  19. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Lupus Caregiving, Defined How Can You Help? Taking Care of Yourself Managing Finances, Legal Matters and Health ... Lupus Q&A with Monica Richey - Preventive Cardiac Care and Lupus Q&A with Susan Gustafson - Health ...

  20. Discoid Lupus Erythematosus

    Science.gov (United States)

    ... and rashes clinical tools newsletter | contact Share | Discoid Lupus Erythematosus Information for adults A A A This image displays typical scarring due to discoid lupus erythematosus. Overview Lupus is a disease in which ...

  1. Lupus Foundation of America

    Science.gov (United States)

    ... You. Learn More About the Lupus Foundation of America We are devoted to solving the mystery of ... Support for Lupus Research The Lupus Foundation of America applauds the U.S. Senate Appropriations Committee for voting ...

  2. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... associated with lupus 15 Questions – Skin Issues and Hair Loss with Lupus 15 Questions - Understanding Lupus 15 ... Planning Assistance Financial Assistance for Healthcare Support for Hair Loss Paticipating in Clinical Trials National Institutes of ...

  3. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Request for Applications Lupus Achievements and Advances Lupus Science & Medicine™ Local Chapters About Us What We Do ... a cruel mystery. Video | Nov. 08, 2012 Advancing Science - Improving Lives Our national lupus research program aggressively ...

  4. What Is Lupus?

    Science.gov (United States)

    ... women with lupus should see their doctors often. Lupus can flare during pregnancy. Pregnancy counseling and planning before pregnancy are important. Women with lupus who do not wish to become pregnant or ...

  5. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... the Finzi Program Scientific Initiatives to Advance Lupus Drug Development LFA-REAL LFA Collective Data Analysis Initiative ... are the common symptoms of lupus? Are chemotherapy drugs used to treat people with lupus? How is ...

  6. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Adult Care 15 Questions – Pediatric Lupus 15 Questions - Reproduction and Contraception Health with Lupus 15 Questions - Men and Lupus 15 Questions - Nervous System Issues 15 Questions - Healthy Eating 15 Questions - Strategies ...

  7. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Applications Lupus Achievements and Advances Lupus Science & Medicine™ Local Chapters About Us What We Do Who We ... Twitter YouTube Lupus.org Get Answers Find Help Local Chapters News & Stories Research Message Boards Store Get ...

  8. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Lead Scientific Initiatives to Address Barriers in Lupus Drug Development LFA-REAL LFA Collective Data Analysis Initiative ... are the common symptoms of lupus? Are chemotherapy drugs used to treat people with lupus? How is ...

  9. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Lead Scientific Initiatives to Address Barriers in Lupus Drug Development LFA-REAL LFA Collective Data Analysis Initiative ... for Applications Lupus Achievements and Advances Lupus Science & Medicine™ Local Chapters About Us What We Do Who ...

  10. Lupus panniculitis

    International Nuclear Information System (INIS)

    Lupus panniculitis (LP) is a benign entity. To our knowledge LP has not been reported in the radiology literature. Our objective is to describe imaging findings as previous articles have not focused on this aspect. Computed Tomography and MR imaging demonstrate lipoatrophy and isolated areas with inflammatory activity in the subcutaneous tissue. (author)

  11. S.L.E. Lupus Foundation

    Science.gov (United States)

    ... World’s Preeminent Driver of Lupus Research More News › Lupus News Tuesday, August 2, 2016 Congressional Lupus Caucus ... LUPUS RESEARCH ALLIANCE NYS Fall Calendar Living with Lupus Home | About Us | Our Programs | About Lupus | Lupus ...

  12. Comorbilidad y hospitalización en pacientes con lupus eritematoso sistémico. Clínica Universitaria Bolivariana, Congregación Mariana y Hospital Pablo Tobón Uribe, Medellín, 2001

    Directory of Open Access Journals (Sweden)

    Martha Herrera

    2001-04-01

    Full Text Available

    El lupus eritematoso sistémico (LES es una enfermedad del
    tejido conectivo caracterizada por formación de anticuerpos y complejos inmunes. Compromete cualquier órgano o sistema. Afecta principalmente a mujeres, con mayor incidencia entre la segunda y quinta décadas de la vida.
    En Estados Unidos la incidencia es de 1.8-7.6 por 100.000
    habitantes por año y la prevalencia oscila entre 15-50 por 100.000 habitantes (1, 2. El lupus genera altos costos institucionales, debido no sólo a la enfermedad en sí, sino también a las complicaciones y a las enfermedades
    comórbidas. El estudio permitirá conocer las comorbilidades
    presentadas en estas tres instituciones, para un adecuado enfoque e intervención temprana de la misma, que se reflejará en una disminución de costos institucionales y mejor calidad de vida de los pacientes.

     

  13. La propiedad intelectual en el derecho tributario chileno y español. Un estudio comparado

    OpenAIRE

    Arellano Quiroz, Marco Antonio

    2014-01-01

    [ES]La tesis estudia la Tributación de la Propiedad Intelectual, para lo cual, utiliza la comparación entre el sistema Español y Chileno. Se inicia con el estudio de la naturaleza jurídica de la propiedad intelectual, luego el análisis económico de su objeto más directo, el avance técnico y posteriormente la revisión de las disposiciones tributarias en Chile y España, para terminar con la revisión de Convenio de Doble Imposición que une a nuestros dos países.

  14. Lupus nephritis and lupus band test.

    OpenAIRE

    Adam, B. A.; Wang, F; Looi, L. M.; Prathap, K.

    1981-01-01

    Twenty-seven patients with histologically confirmed lupus nephritis were studied to identify the incidence of lupus band and its significance to histological patterns of nephritis and complement levels. It was found that the kidney involvement is 2.5 times more frequent in lupus band positive patients. The association of a positive lupus and low C3 level signifies the presence of diffuse proliferative glomerulonephritis rather than membranous glomerulonephritis. The results, together with ear...

  15. Sagitta chilensis nueva especie de quetognato en fiordos australes chilenos (Chaetognatha, Aphragmophora, Sagittidae) Sagitta chilensis a new species of chaetognath in Chilean fjords (Chaetognatha, Aphragmophora, Sagittidae)

    OpenAIRE

    Francisco Villenas; Sergio Palma

    2006-01-01

    Se describe por primera vez una nueva especie de quetognato del orden Aphragmophora, Sagitta chilensis n. sp., colectada en fiordos australes chilenos. Se analizaron 1065 ejemplares colectados entre la boca del Guafo y el canal Pulluche en noviembre de 2002. Estos ejemplares presentaron marcadas diferencias morfológicas con otras especies afines, como estructuras puntiagudas en el collarete y aletas, forma de aletas anteriores y posteriores, posición de las vesículas seminales y presencia de ...

  16. LAS METAS MÚLTIPLES: ANÁLISIS PREDICTIVO DEL RENDIMIENTO ACADÉMICO EN ESTUDIANTES CHILENOS

    OpenAIRE

    Leandro Navas Martínez; José Antonio Soriano Llorca; Francisco Pablo Holgado Tello; Irene Jover Mira

    2016-01-01

    Este estudio parte de la perspectiva que analiza el contenido de las metas en contextos académicos para explicar la motivación para los estudios. El objeti - vo es analizar la estructura que presentan las metas múltiples en estudiantes chilenos y sus relaciones con el rendimiento académico. Esto implica valorar las cualidades psicométricas del Cuestionario de Metas y valorar la contri - bución de las diferentes metas como variables predictoras del rendimiento académico. Participan 1773 es...

  17. Resultados clínicos de trasplantes de riñón en pacientes con enfermedad renal en etapa terminal secundaria a nefritis lupus, enfermedad poliquística renal y nefropatía diabética

    Directory of Open Access Journals (Sweden)

    John Fredy Nieto-Ríos

    2016-04-01

    Full Text Available Antecedentes:Pacientes con nefritis lúpica pueden progresar a enfermedad renal crónica terminal (10-22%; en estos pacientes el trasplante renal debe ser considerado como la terapia de elección. Objetivo: Evaluar los desenlaces clínicos de un grupo de pacientes con enfermedad renal crónica terminal por nefropatía lúpica, enfermedad renal poliquística y nefropatía diabética que fueron sometidos a trasplante renal en el Hospital Pablo Tobón Uribe.Métodos:Estudio retrospectivo, descriptivo, realizado en un solo centro de trasplante renal, durante el período 2005-2013.Resultados:Se evaluaron 136 pacientes: 27 con nefritis lúpica (19.9%, 31 con enfermedad renal poliquística (22.8% y 78 con nefropatía diabética (57.4%. La supervivencia del injerto a uno, tres y cinco años fue de de 96.3%, 82.5% y 82.5% en nefropatía lúpica, 90%, 86% y 76.5% en enfermedad renal poliquística y 91.7%, 80.3% y 67.9% en nefropatía diabética respectivamente, sin diferencias estadísticas significativas (Long Rank test= 0.488. La tasa de recurrencia de nefritis lúpica posterior al trasplante renal fue de 0.94%/persona-año. Tener lupus vs diabetes o enfermedad renal poliquística no fue un factor de riesgo para disminución del tiempo de supervivencia del injerto (Hazard ratio= 1.43; 95% IC= 0.52-3.93.Conclusiones:Los pacientes enfermedad renal crónica terminal secundaria a nefritis lúpica, que son llevados a trasplante renal tienen tasas de éxito similar en cuanto a supervivencia del injerto y del paciente, al compararlos con otras enfermedades renales. La tasa de complicaciones y el riesgo de recurrencia de la nefropatía lúpica son bajos. El trasplante renal debe ser considerado como la terapia de elección para los pacientes con enfermedad renal crónica estadio terminal secundaria a nefritis lúpica.

  18. Una nueva estructura de garantías para los bonos chilenos de infraestructura

    Directory of Open Access Journals (Sweden)

    Werner Kristjanpoller Rodríguez

    2011-12-01

    Full Text Available El sistema chileno de concesiones ha sido uno de los fundamentos del desarrollo del país y ha creado una fuerte relación entre el sector público y el sector privado para financiar grandes obras. La reciente crisis financiera destruyó la confianza en las compañías de seguros "monolínea", las cuales aseguran los bonos de infraestructura de Chile aumentando su calificación de riesgo a AAA a nivel internacional. En este contexto es necesario estudiar nuevas estructuras de garantías para estos bonos, en particular para proyectos superiores a 200 millones de dólares. Se proponen dos alternativas: una Sociedad de Garantía y garantías de contratos de concesión con cobertura privada.

  19. Movimiento estudiantil chileno de 2011 y su influencia en las reivindicaciones ciudadanas desde los márgenes regionalistas

    Directory of Open Access Journals (Sweden)

    Javier Ramos Galleguillos

    2013-06-01

    Full Text Available Uno de los conflictos sociales más significativos del año 2011 en Chile, fue el movimiento estudiantil, que en conjunto con diversos actores sociales, promovieron la consigna de una educación pública, democrática y de calidad. Bajo este argumento, la presente ponencia pretende analizar y describir de qué manera el Movimiento Estudiantil chileno iniciado en 2011, gatilla un empoderamiento ciudadano contra el régimen político y económico en favor de un Estado de Bienestar transversal a los distintos sectores sociales. Se indaga además, en las repercusiones que tuvo este Movimiento para la formulación de nuevas demandas desde los márgenes regionalistas, con el fin de interpretar el creciente descontento ciudadano y su necesidad de organización orientado a romper con la brecha de desigualdad existente en Chile.

  20. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Lupus Day Become a Media Spokesperson Become an Activist Participate in a Clinical Trial Fundraise Your Way ... Now Walk to End Lupus Now Become an Activist Participate in a Clinical Trial CFC #10566 Ways ...

  1. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... all people affected by lupus. Share This Page Facebook Twitter Email Print Tags for this Story treatments ... email updates First Name: Email Address: Get social Facebook Twitter YouTube Lupus.org Get Answers Find Help ...

  2. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Program™) How to Apply for Funding Lupus Science & Medicine™ Local Chapters About Us What We Do Who ... program aggressively seeks to advance the science and medicine of lupus and to improve the quality of ...

  3. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... and Stress Q&A with Dr. Ronenn Roubenoff - Nutrition and Lupus 15 Questions - Depression and Lupus 15 ... Financial Assistance Scholarships Prescription Assistance Additional Financial Services Food Assistance Transportation Assistance Housing and Utility Assistance Financial ...

  4. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... to Address Barriers in Lupus Drug Development LFA-REAL LFA Collective Data Analysis Initiative LFA Flare Definition ... Magazine © 2016 Lupus Foundation of America, Inc. All Rights Reserved | Privacy Policy | Terms of Use

  5. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Research Current Research Focus and Priorities Funded Research Projects and Awards Investigator Grants, Fellowships and Career Development ... of lupus and to improve the quality of life for all people affected by lupus. Share This ...

  6. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Care and Lupus Q&A with Susan Gustafson - Health Insurance Marketplace Q&A with Dr. Betsy Blazek-O’Neill - Complementary Care and Lupus Q&A with Paul DelPonte - Caregiving ...

  7. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... On Purple Toolkit World Lupus Day Become a Media Spokesperson Become an ... provides a brief overview of lupus and its symptoms and health effects, and an introduction to some of the information ...

  8. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Resources Travel to the United States for Medical Treatment: What You Should Know News & Stories Research We ... Facebook Twitter Email Print Tags for this Story treatments symptoms Lupus FAQ What is lupus? What are ...

  9. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Menu Donate Now Get Answers Frequently Asked Questions I Might Have Lupus I Have Lupus I'm a Friend or Family Member I'm a Caregiver Help & Resources For Patients, Families ...

  10. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... and medicine of lupus and to improve the quality of life for all people affected by lupus. ... email updates Email Address: ZIP / Postal Code: Spam Control Text: Please leave this field empty Get social ...

  11. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... 15 Questions - Nervous System Issues 15 Questions - Healthy Eating 15 Questions - Strategies for Restful Sleep 15 Questions - ... what makes lupus so different from many other diseases and why lupus is a cruel mystery. Video | ...

  12. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Lupus Drug Development LFA-REAL LFA Collective Data Analysis Initiative LFA Flare Definition LFA Professional Online Instrument ... Employment Opportunities & Internships The American Lupus Society (TALS) Financials Annual Report Financial Accountability How Donations are Used ...

  13. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... MSAC (Medical and Scientific Advisory Council) International Resources Travel to the United States for Medical Treatment: What ... Have Lupus I Have Lupus I'm a Friend or Family Member I'm a Health Professional ...

  14. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... for Children and Teens How to Help: A Communication Tool for Caregivers and Loved Ones with Lupus ... overview of lupus and its symptoms and health effects, and an introduction to some of the information ...

  15. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Data Analysis Initiative LFA Flare Definition LFA Professional Online Instrument Training Program (POINT Program™) We Fund Lupus ... Lupus Foundation of America, Inc. All Rights Reserved | Privacy Policy | Terms of Use

  16. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... 15 Questions - Men and Lupus 15 Questions - Nervous System Issues 15 Questions - Healthy Eating 15 Questions - Strategies ... 15 Questions - Disability: Working Your Way Through the System 15 Questions - Back to School with Lupus 15 ...

  17. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... all people affected by lupus. Share This Page Facebook Twitter Email Print Tags for this Story treatments ... Text: Please leave this field empty Get social Facebook Twitter YouTube Lupus.org Get Answers Find Help ...

  18. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Resources Travel to the United States for Medical Treatment: What You Should Know News & Stories Research Our ... Facebook Twitter Email Print Tags for this Story treatments symptoms Lupus FAQ What is lupus? What are ...

  19. Treatment of lupus nephritis

    NARCIS (Netherlands)

    Dolff, Sebastian; Berden, Jo H. M.; Bijl, Marc

    2010-01-01

    Renal involvement in systemic lupus erythematosus patients is a severe disease manifestation characterized by various clinical and histopathological alterations The revised International Society of Nephrology/Renal Pathology Society 2003 classification defines the subclasses of lupus nephritis (LN)

  20. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Doctor's Appointment Support Groups For Healthcare Professionals Continuing Education Tools for Your Patients Research and Clinical Trials ... what makes lupus so different from many other diseases and why lupus is a cruel mystery. Video | ...

  1. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... POINT Program™) How to Apply for Funding Lupus Science & Medicine™ Local Chapters About Us What We Do ... a cruel mystery. Video | Nov. 08, 2012 Advancing Science - Improving Lives Our national lupus research program aggressively ...

  2. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... 15 Questions - Kidney Issues and Lupus 15 Questions – Pulmonary Issues and Lupus 15 Questions – Dealing with Stress ... Social Security Disability Applying for Social Security Disability Work Related Issues Financial Assistance Scholarships Prescription Assistance Additional ...

  3. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... for Children and Teens How to Help: A Communication Tool for Caregivers and Loved Ones with Lupus ... On Purple Toolkit World Lupus Day Become a Media Spokesperson Become an Activist Participate in a Clinical ...

  4. Lupus Activity in Pregnancy

    OpenAIRE

    Clowse, Megan E. B.

    2007-01-01

    Pregnancy in a woman with Systemic Lupus Erythematosus (SLE) can be complicated by both lupus activity and pregnancy mishaps. The majority of recent studies demonstrate an increase in lupus activity during pregnancy, perhaps exacerbated by hormonal shifts required to maintain pregnancy. Increased lupus activity, in turn, prompts an elevated risk for poor pregnancy outcomes, including stillbirth, preterm birth, low birth weight, and preeclamspsia. Fortunately, the majority of pregnancies in wo...

  5. Lupus nephritis: current update

    OpenAIRE

    Saxena, Ramesh; Mahajan, Tina; Mohan, Chandra

    2011-01-01

    Lupus nephritis is a major cause of morbidity and mortality in patients with systemic lupus erythematosus. The general consensus is that 60% of lupus patients will develop clinically relevant nephritis at some time in the course of their illness. Prompt recognition and treatment of renal disease is important, as early response to therapy is correlated with better outcome. The present review summarizes our current understanding of the pathogenic mechanisms underlying lupus nephritis and how th...

  6. Target Awareness: Lupus

    Medline Plus

    Full Text Available Lupus Foundation of America En Español Follow @LupusOrg Email Address: ZIP / Postal Code: Spam Control Text: Please leave this ... information and support services available from the Lupus Foundation of America and its national network of chapters ...

  7. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... I Have Lupus I'm a Friend or Family Member I'm a Caregiver Help & Resources For Patients, Families and Caregivers Caregiving: What You Need to Know ... Questions - Gastrointestinal Issues with Lupus 15 Questions - Balancing Family, Friends, Activities and Lupus 15 Questions - Disability: Working ...

  8. Efectividad de un programa educacional multidisciplinar estandarizado en enfermos con artritis reumatoide, lupus eritematoso sistémico y espondilitis anquilosante

    OpenAIRE

    Cano García, Laura

    2014-01-01

    En la actualidad, hay que optimizar los recursos sanitarios disponibles consiguiendo el máximo de eficiencia. Un programa educacional grupal multidisciplinar puede aportar recursos de varios profesionales sanitarios con un coste sanitario mínimo. Objetivo: Evaluar si los resultados de una intervención educativa estandarizada para mejorar la calidad de vida relacionada con la salud (CVRS), la función física, la adherencia terapéutica y el dolor es igualmente efectiva en los 3 grupos diagnós...

  9. EL OCASO DE LA CLAUSURA: MUJERES, RELIGIÓN Y ESTADO NACIONAL. EL CASO CHILENO

    Directory of Open Access Journals (Sweden)

    Sol Serrano

    2009-12-01

    Full Text Available La decadencia del modelo religioso femenino representado por los conventos de monjas contemplativas, entre fines del XVIII y la primera mitad del siglo XIX, es parte de un proceso de reforma propia del despotismo ilustrado, del liberalismo de los estados nacionales y también, en el caso chileno que aquí se estudia, del reformismo eclesiástico. Este artículo sugiere que las monjas contemplativas dejaron de ser mujeres para el liberalismo, por no cumplir su rol de madres, y en el catolicismo fueron desplazadas por las religiosas de vida activa, que eran un modelo de religiosas en el mundo que cumplían roles de madres sociales. La exclusión de las mujeres de los derechos políticos está vinculada con este proceso, en cuanto la formación del nuevo espacio público requería la formación de un espacio privado gobernado por madres. Este artículo estudia las tres etapas del reformismo ilustrado, del liberal y del religioso en el caso chileno.The decline of the women religious model represented by contemplative nun convents between the end of the eighteenth century and the first half of the nineteenth, was part of a reform process experienced in different spheres of influence. Among them it is possible to mention the enlightened despotism, the liberalism exerted by National States and the ecclesiastical reformism of Chile. This article shows that contemplative nuns stopped being considered as women for liberalism because they did not fulfill a mother role. Moreover they were displaced within the Catholic realm by religious women with active roles in society, who fulfilled the role of social mothers. The exclusion of women from the enjoyment of political rights was linked to this process because the formationof a new public space required the conformation of a private space governed by mothers.

  10. Cine chileno e industria… el desafío que falta

    Directory of Open Access Journals (Sweden)

    Fernando Véliz M.

    2006-01-01

    Full Text Available El cine chileno es un campo discursivo de la industria audiovisual aún en proceso de crecimiento. Su historia está cargada de imprecisiones y múltiples inicios que muchas veces quedan truncos; es un cine que se ha comprometido con los problemas sociales, pero que también ha sabido de lejanías y silencios impuestos; es un cine artesanal que aspira a mirar como industrial; es un cine que narra desde el tercer mundo, muchas veces con un 98% de consumo (en sus momentos más fuertes de producción norteamericana; es decir, es un cine que se ha formado en la autogestión absoluta de su capital simbólico. Es un cine que, por medio de libros y películas de culto, está generando una nueva camada de directores, los cuales buscan comprender su rol en esta industria que hoy, ya con el pasar del tiempo, tiene audiencias cautivas. Es un cine que a ratos camina junto al Estado y, en otras ocasiones, es la soledad su compañera de ruta. Es un cine fundado en la creatividad, búsqueda y superación de su oficio, y que poco a poco, comprende que el valor agregado está en sus historias locales.

  11. Un Modelo de Vectores Autorregresivos para el Mercado Financiero Chileno Un Modelo de Vectores Autorregresivos para el Mercado Financiero Chileno

    OpenAIRE

    Christian Johnson

    1992-01-01

    Un Modelo de Vectores Autorregresivos para el Mercado Financiero Chileno Using various econometric techniques, the paper estimates the impact that interest-rare-based stabilization policy has on asset prices. To this end, vector autoregresive (VAR), as well as cointegration, error correction, and bayesian models (BVAR) were used. The results show that the disequilibria in these markets resulting from diferent shock, disappear only one year after they occur. These findings suggest that there m...

  12. Living with Lupus (For Parents)

    Science.gov (United States)

    ... Things to Know About Zika & Pregnancy Living With Lupus KidsHealth > For Parents > Living With Lupus Print A ... disease for both doctors and their patients. About Lupus A healthy immune system produces proteins called antibodies ...

  13. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Questions - Gastrointestinal Issues with Lupus 15 Questions - Balancing Family, Friends, Activities ... Planning Assistance Financial Assistance for Healthcare Support for Hair ...

  14. Invarianza factorial de la Escala para la Detección de Ansiedad Social (EDAS) en adolescentes españoles y chilenos

    OpenAIRE

    Piqueras, José Antonio; Olivares, José; Vera Villarroel, Pablo; Marzo, Juan Carlos; Kuhne, Walter

    2012-01-01

    Este estudio instrumental examina la invarianza factorial de la Escala para la Detección de Ansiedad Social (EDAS) en función del país y el sexo en dos muestras de adolescentes españoles y chilenos entre 14 y 17 años empleando el análisis factorial confirmatorio multigrupo. La muestra española estuvo compuesta por 1185 adolescentes españoles, con edad media 15.49 (1.10) y la muestra chilena estuvo formada por 965 adolescentes, cuya edad media fue 15.51 (1.09). La distribución por edad y sexo ...

  15. La TV por IP en la Universidad: Un reto de divulgación científica televisiva para jóvenes chilenos

    OpenAIRE

    Torrales Aguirre, Daniel; Aguaded Gómez, José Ignacio; Ponce Guardiola, Daniel

    2013-01-01

    Diseñar nuevos modelos de televisión en el contexto de la sociedad digital se convierte en una necesidad desde el ámbito de la investigación y la academia. El presente trabajo analiza los intereses y necesidades de información expresados por jóvenes espectadores chilenos, con el objeto de diseñar una IPTV universitaria, modalidad de TV por Internet, que incorpora, mediante las múltiples interacciones que genera Internet los contenidos audiovisuales preferidos por dicho público met...

  16. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Investigator Prize About Dr. Mary Betty Stevens Career Development Award Gina M. Finzi Memorial Student Summer Fellowship Program Submit an Application About the Finzi Program Request for Applications Lupus Achievements and Advances Lupus Science & Medicine™ Local Chapters About Us What We Do Who We ...

  17. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... I Have Lupus I'm a Friend or Family Member I'm a Caregiver Help & Resources For Patients, Families and Caregivers Caregiving: What You Need to Know ... Scientific Initiatives to Address Barriers in Lupus Drug Development LFA-REAL LFA Collective Data Analysis Initiative LFA ...

  18. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Stevens Career Development Award Gina M. Finzi Memorial Student Summer Fellowship Program Submit an Application About the ... the Lupus Foundation of America and its national network of chapters and field offices. Related Stories Video | ... Lupus.org Get Answers Find ...

  19. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Get Answers Find Help Local Chapters News & Stories Research Message Boards Store Get Answers Frequently Asked Questions I Might Have Lupus I Have Lupus I'm a Friend or Family Member I'm a Health Professional ...

  20. Un Modelo de Vectores Autorregresivos para el Mercado Financiero Chileno Un Modelo de Vectores Autorregresivos para el Mercado Financiero Chileno

    Directory of Open Access Journals (Sweden)

    Christian Johnson

    1992-03-01

    Full Text Available Un Modelo de Vectores Autorregresivos para el Mercado Financiero Chileno Using various econometric techniques, the paper estimates the impact that interest-rare-based stabilization policy has on asset prices. To this end, vector autoregresive (VAR, as well as cointegration, error correction, and bayesian models (BVAR were used. The results show that the disequilibria in these markets resulting from diferent shock, disappear only one year after they occur. These findings suggest that there may be some benefits associated to a monetary policy aimed at short run financial market stabilization. This might avoid strong and persistent disequilibria in equity and exchange market.

  1. Estructura factorial y consistencia interna del inventario de liderazgo distribuido (DLI en docentes chilenos

    Directory of Open Access Journals (Sweden)

    López Alfaro, Pablo

    2015-09-01

    Full Text Available Este artículo presenta el análisis de la estructura factorial y consistencia interna del instrumento “The Distributed Leadership Inventory (DLI” en docentes primarios chilenos. Participaron voluntariamente 511 educadores (379 mujeres, 132 hombres en ejercicio, pertenecientes a las siguientes regiones: Metropolitana, Segunda, Quinta, Octava y Novena, en el periodo marzo-septiembre del año 2014. Se realizó el análisis factorial exploratorio y el análisis factorial confirmatorio con ecuaciones estructurales para obtener evidencias de validez de constructo y consistencia interna. Estos estudios confirmaron una distribución de los reactivos en cinco factores del instrumento, indicando un buen ajuste a los datos, al igual que el valor del error de aproximación cuadrático medio (RMSEA. Sin embargo, un conjunto de ítems presentó un comportamiento inadecuado en la matriz factorial resultante, por lo que fue eliminado. Estos resultados son satisfactorios y parcialmente consistentes con investigaciones teóricas y empíricas relacionadas con el constructo. Se concluye que la validación del DLI, desde un punto de vista estadístico, permite la medición de la percepción del liderazgo distribuido de manera consistente. Además, posibilita la comparación de resultados entre poblaciones y variables de interés para el desarrollo de procesos organizacionales, tales como: el apoyo, la supervisión, la participación y la cooperación inherente a los docentes.Este artículo presenta el análisis de la estructura factorial y consistencia interna del instrumento “The Distributed Leadership Inventory (DLI” en docentes primarios chilenos. Participaron voluntariamente 511 educadores (379 mujeres, 132 hombres en ejercicio, pertenecientes a las siguientes regiones: Metropolitana, Segunda, Quinta, Octava y Novena, en el periodo marzo-septiembre del año 2014. Se realizó el análisis factorial exploratorio y el análisis factorial confirmatorio con

  2. ESTRUCTURA FACTORIAL Y CONSISTENCIA INTERNA DEL INVENTARIO DE LIDERAZGO DISTRIBUIDO (DLI EN DOCENTES CHILENOS

    Directory of Open Access Journals (Sweden)

    Pablo López Alfaro

    2015-01-01

    Full Text Available Este artículo presenta el análisis de la estructura factorial y consistencia interna del instrumento “The Distributed Leadership Inventory (DLI” en docentes primarios chilenos. Participaron voluntariamente 511 educadores (379 mujeres, 132 hombres en ejercicio, pertenecientes a las siguientes regiones: Metropolitana, Segunda, Quinta, Octava y Novena, en el periodo marzo-septiembre del año 2014. Se realizó el análisis factorial exploratorio y el análisis factorial confirmatorio con ecuaciones estructurales para obtener evidencias de validez de constructo y consistencia interna. Estos estudios confirmaron una distribución de los reactivos en cinco factores del instrumento, indicando un buen ajuste a los datos, al igual que el valor del error de aproximación cuadrático medio (RMSEA. Sin embargo, un conjunto de ítems presentó un comportamiento inadecuado en la matriz factorial resultante, por lo que fue eliminado. Estos resultados son satisfactorios y parcialmente consistentes con investigaciones teóricas y empíricas relacionadas con el constructo. Se concluye que la validación del DLI, desde un punto de vista estadístico, permite la medición de la percepción del liderazgo distribuido de manera consistente. Además, posibilita la comparación de resultados entre poblaciones y variables de interés para el desarrollo de procesos organizacionales, tales como: el apoyo, la supervisión, la participación y la cooperación inherente a los docentes.

  3. Incesto y Lupus Eritematoso Sistémico

    Directory of Open Access Journals (Sweden)

    José Vicente Arévalo Álvarez

    2003-01-01

    Full Text Available El lupus eritematoso sistémico es considerada una enfermedad autoinmune, incurable y de difícil tratamiento. A través de la experiencia  clínica con 17 casos de mujeres desahuciadas, se ha encontrado una poderosa conexión entre un disparador como lo es el incesto con el padre y la aparición de la enfermedad. El tratamiento con la hipnoterapia ha dado resultados espectaculares.

  4. Incesto y Lupus Eritematoso Sistémico

    OpenAIRE

    José Vicente Arévalo Álvarez

    2003-01-01

    El lupus eritematoso sistémico es considerada una enfermedad autoinmune, incurable y de difícil tratamiento. A través de la experiencia  clínica con 17 casos de mujeres desahuciadas, se ha encontrado una poderosa conexión entre un disparador como lo es el incesto con el padre y la aparición de la enfermedad. El tratamiento con la hipnoterapia ha dado resultados espectaculares.

  5. LUPUS ERITEMATOSO CUTÁNEO: ANÁLISIS CLÍNICOS Y DE LABORATORIO

    OpenAIRE

    Priscila Maria da Silva Gomes

    2015-01-01

    El lupus eritematoso (LE) se incluye entre las llamadas enfermedades del tejido conectivo y se divide en una forma sistémica lupus eritematoso sistémico (LES) y una forma eritematoso piel lupus cutáneo (LEC). La LE es una enfermedad autoinmune heterogénea y multisistémica caracterizada por la producción de anticuerpos que combaten su propio cuerpo en lugar de antígenos que luchan. El lupus es una enfermedad con mayor frecuencia entre las edades de 20 a 50 años, que afecta a más mujeres que h...

  6. Seguros de salud públicos y privados: el caso chileno

    Directory of Open Access Journals (Sweden)

    Luis García Núñez

    1999-06-01

    Full Text Available En las últimas dos décadas Chile experimentó una profunda reforma en el área de los seguros de salud, estableciéndose una nueva configuración del sector con la coexistencia de un seguro público de salud junto a seguros privados. Este ensayo analiza un hecho estilizado del caso chileno: la presencia mayoritaria de personas de bajos ingresos y alto riesgo en el seguro público, observándose todo lo contrario en los seguros privados. Se desarrolla un modelo bisectorial basado en la teorfa estándar de seguros, el cual explica por qué razones las personas escogen entre el seguro público o algún seguro privado dadas las reglas de juego de los dos sub-sistemas.---In the last two decades, the Chilean health sector suffered a deep reform, establishing a new scheme with two sectors: the public health insurance and many private health insurance companies. This essay analyzes a especial outcome in the Chilean health insurance sector: the majority of the people within the public health insurance belong to a group with low incomes and high risk, noticing the opposite situation in the private health system. This paper develops a two-sector model based on the standard insurance theory, which explains the reasons why people choose between the public health insurance and a private health insurance, given the rules of both sub-systems.

  7. Análisis factorial confirmatorio de la Escala de habilidades sociales en universitarios chilenos

    Directory of Open Access Journals (Sweden)

    Edgardo Miranda-Zapata

    2014-01-01

    Full Text Available Se presenta un estudio psicométrico por procedimientos confirmatorios de la Escala de habilidades sociales de Gismero. Se revisan antecedentes generales sobre instrumentos habitualmente utilizados para evaluar habilidades sociales, y se presentan las características generales del instrumento estudiado, revisando las propiedades psicométricas de medida del mismo. La muestra estuvo compuesta por 1206 estudiantes universitarios de distintas carreras de la Universidad Católica de Temuco, Chile. Se realizó un análisis factorial confirmatorio con la matriz de correlaciones policóricas, y se analizó la estructura propuesta por Gismero. De la misma forma, se realizan procedimientos de evaluación de fiabilidad como consistencia interna (alfa ordinal y análisis de validez discriminante utilizando los factores del autoconcepto forma 5. Los resultados indican una buena fiabilidad del instrumento, un ajuste adecuado del modelo a los datos y una adecuada validez discriminante. Por lo cual, se considera que la Escala de habilidades sociales es un instrumento recomendable para la evaluación de las habilidades sociales en estudiantes universitarios chilenos. Se propone una leve modificación en la estructura del modelo en el ámbito de los fac tores de segundo orden.

  8. Cutaneous lupus erythematosus

    DEFF Research Database (Denmark)

    Biazar, Cyrus; Sigges, Johanna; Patsinakidis, Nikolaos;

    2013-01-01

    In this prospective, cross-sectional, multicenter study, we assessed clinical and laboratory characteristics from patients with cutaneous lupus erythematosus (CLE) using the Core Set Questionnaire of the European Society of Cutaneous Lupus Erythematosus (EUSCLE). 1002 (768 females, 234 males...... included gender, age at onset of disease, LE-specific and LE-nonspecific skin lesions, photosensitivity, laboratory features, and the criteria of the American College of Rheumatology (ACR) for the classification of systemic lupus erythematosus. The mean age at onset of disease was 43.0±15.7 years and...

  9. TRANSITION CIRCUMNSTELLAR DISKS IN LUPUS

    Directory of Open Access Journals (Sweden)

    G. A. Romero

    2011-01-01

    Full Text Available Presentamos un estudio de discos de transición situados en la región de Lupus que han sido seleccionados en base a datos obtenidos por Spitzer. Varios mecanismos han sido propuestos para explicar su más distintiva característica: agujeros en la opacidad en la parte interna del disco y discos ópticamente gruesos en su parte externa. Ellos son: formación de planetas, crecimiento de los granos de polvo, fotoevaporación, truncamiento del disco por efecto de marea en sistemas binarios cercanos. Hemos llevado a cabo observaciones con óptica adaptiva en el infrarrojo cercano, fotometría submilimétrica, y espectroscopía de alta resolución con el fin de caracterizar estos nuevos discos de transición. Con los datos analizados, proponemos cómo distinguir cuales mecanismos fíisicos prevalecen en ellos y encontrar candidatos que alberguen planetas en formacion para ser estudiados posteriormente con las capacidades de Herschell y ALMA.

  10. Implementación de un programa de estimulación cognitiva en personas con demencia tipo Alzheimer: un estudio piloto en chilenos de la tercera edad / Implementation of a Cognitive Stimulation Program for People with Alzheimer Disease: A Pilot Study in a Chilean Elderly Sample

    Directory of Open Access Journals (Sweden)

    Claudia Miranda Castillo

    2013-06-01

    Full Text Available La Terapia de Estimulación Cognitiva (TEC es una intervención psicosocial para personas con demencia que ha obtenido buenos resultados en población anglosajona. El objetivo de este estudio fue evaluar la eficacia de la TEC en una muestra de personas chilenas. Participaron 22 pacientes con diagnóstico de Enfermedad de Alzheimer (EA en fase leve a moderada, pertenecientes a un centro asistencial de la ciudad de Quillota, Chile. Para determinar la eficacia del programa, se definió un diseño experimental mixto 2x2 de medidas repetidas, asignándose aleatoriamente la muestra a dos grupos: intervención (GI y control (GC. Se establecieron tres dimensiones para evaluar: cognición, calidad de vida y capacidad funcional de la persona con demencia. Posterior a la intervención, el GI presentó una mejoría significativa en sus indicadores de deterioro cognitivo y calidad de vida; por el contrario, el GC no evidenció cambios positivos en ninguna dimensión, empeorando el declive cognitivo. Ninguno de los grupos experimentó cambios significativos en la capacidad funcional. Si bien en la comparación intergrupo no existieron diferencias significativas en ninguna variable, el GI presentó una mejoría sustancial de la función cognitiva, en comparación con el aumento en la progresión del deterioro cognitivo en el GC. Se recomienda que futuras investigaciones contrasten dichos resultados utilizando una muestra más grande de personas con EA.

  11. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... National Board of Directors Medical-Scientific Advisory Council Management Team Employment Opportunities & Internships The American Lupus Society ( ... m a Caregiver About Us Board of Directors Management Team Medical-Scientific Advisory Council Government Relations Financial ...

  12. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... A with Sheri R. Abrams - Social Security and Disability Q&A with Dr. Betsy Blazek-O’Neill: ... Balancing Family, Friends, Activities and Lupus 15 Questions - Disability: Working Your Way Through the System 15 Questions - ...

  13. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... a Clinical Trial Fundraise Your Way New York City Gala Message Boards | Store News & Stories Blog General ... Magazine © 2016 Lupus Foundation of America, Inc. All Rights Reserved | Privacy Policy | Terms of Use

  14. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... American Lupus Society (TALS) Financials Annual Report Financial Accountability How Donations are Used Contact Us Take Action ... Team Medical-Scientific Advisory Council Government Relations Financial Accountability Employment & Internships Contact Us Press Center Take Action ...

  15. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Preparing for a Medical Emergency Finding a New Doctor Loss of Health Insurance Coverage Preparing for Financial ... Effectiveness Research (CER) Glossary of Terms Find a Doctor Doctors Who Treat Lupus Locating a Doctor In ...

  16. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Patients Research and Clinical Trials MSAC (Medical and Scientific Advisory Council) International Resources Travel to the United ... You Should Know News & Stories Research We Lead Scientific Initiatives to Address Barriers in Lupus Drug Development ...

  17. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Recipients 2014 LIFELINE Grant Program™ Recipients Lupus Insight Prize Evelyn V. Hess, MD, MACP, MACR, Award About ... V. Hess Mary Betty Stevens, MD, Young Investigator Prize About Dr. Mary Betty Stevens Career Development Award ...

  18. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Program 2014 LIFELINE Grant Program™ Recipients Lupus Insight Prize Evelyn V. Hess, MD, MACP, MACR, Award About ... V. Hess Mary Betty Stevens, MD, Young Investigator Prize About Dr. Mary Betty Stevens Career Development Award ...

  19. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... and Loved Ones with Lupus Ask the Experts Educational Programs Transcripts from Previous Expert Q&As Q& ... Trials MSAC (Medical and Scientific Advisory Council) International Resources Travel to the United States for Medical Treatment: ...

  20. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... 15 Questions - Nervous System Issues 15 Questions - Healthy Eating 15 Questions - Strategies for Restful Sleep 15 Questions - ... On Purple Toolkit World Lupus Day Become a Media Spokesperson Become an Activist Participate in a Clinical ...

  1. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Preparing for Financial Emergencies Important Documents Caring for Children and Teens How to Help: A Communication Tool ... Magazine © 2016 Lupus Foundation of America, Inc. All Rights Reserved | Privacy Policy | Terms of Use

  2. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... for Children and Teens How to Help: A Communication Tool for Caregivers and Loved Ones with Lupus ... REAL LFA Collective Data Analysis Initiative LFA Flare Definition LFA Professional Online Instrument Training Program (POINT Program™) ...

  3. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... 15 Questions - Disability: Working Your Way Through the System 15 Questions - Back to School with ... effects, and an introduction to some of the information and support services available from the Lupus Foundation ...

  4. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Your Loved One’s Finances? Do You Have Legal Authority to Make Decisions? Become Familiar With Your Loved ... 15 Questions – Dealing with Stress of Being a Parent with Lupus 15 Questions - Transitioning from Pediatric to ...

  5. Systemic Lupus Erythematosus

    Science.gov (United States)

    ... balanced diet, and exercising regularly. Reduce stress. Avoid smoking and limit alcohol use. When to Seek Medical Care See your doctor if you develop a rash with fever and fatigue. Treatments Your Physician May Prescribe Lupus can be difficult ...

  6. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Board of Directors Medical-Scientific Advisory Council Management Team Employment Opportunities & Internships The American Lupus Society (TALS) ... a Caregiver About Us Board of Directors Management Team Medical-Scientific Advisory Council Government Relations Financial Accountability ...

  7. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Medical-Scientific Advisory Council Management Team Employment Opportunities & Internships The American Lupus Society (TALS) Financials Annual Report ... Scientific Advisory Council Government Relations Financial Accountability Employment & Internships Contact Us Press Center Take Action Donate Now ...

  8. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Doctor's Appointment Support Groups For Healthcare Professionals Continuing Education Tools for Your Patients Research and Clinical Trials ... Initiative LFA Flare Definition LFA Professional Online Instrument Training Program (POINT Program™) We Fund Lupus Investigators Directly ...

  9. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Lupus Q&A with Sheri R. Abrams - Social Security and Disability Q&A with Dr. Betsy Blazek- ... Life Insurance Employment, Disability and Legal Issues Social Security Disability Applying for Social Security Disability Work Related ...

  10. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Friend or Family Member I'm a Caregiver Help & Resources For Patients, Families and Caregivers Caregiving: What ... Someone with Lupus Caregiving, Defined How Can You Help? Taking Care of Yourself Managing Finances, Legal Matters ...

  11. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... 15 Questions - Nervous System Issues 15 Questions - Healthy Eating 15 Questions - Strategies for Restful Sleep 15 Questions - ... all people affected by lupus. Share This Page Facebook Twitter Email Print Tags for this Story treatments ...

  12. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... of Health Insurance Coverage Preparing for Financial Emergencies Important Documents Caring for Children and Teens How to Help: A Communication Tool for Caregivers and Loved Ones with Lupus ...

  13. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... and Loved Ones with Lupus Ask the Experts Educational Programs Transcripts from Previous Expert Q&As Q& ... Trials National Institutes of Health PARTNERS About PARTNERS Research Comparative Effectiveness Research (CER) Glossary of Terms Find ...

  14. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Scientific Initiatives to Address Barriers in Lupus Drug Development LFA-REAL LFA Collective Data Analysis Initiative LFA Flare Definition LFA Professional Online Instrument Training Program (POINT Program™) We Fund ...

  15. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... REAL LFA Collective Data Analysis Initiative LFA Flare Definition LFA Professional Online Instrument Training Program (POINT Program™) ... Magazine © 2016 Lupus Foundation of America, Inc. All Rights Reserved | Privacy Policy | Terms of Use

  16. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Council Government Relations Financial Accountability Employment & Internships Contact Us Press Center Take Action Donate Now Walk to End Lupus Now Become an Activist Participate in a Clinical Trial CFC #10566 Ways to Give Find a Local ...

  17. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Insurance Health Insurance Options Medicare Medicaid Life Insurance Employment, Disability and Legal Issues Social Security Disability Applying ... of Directors Medical-Scientific Advisory Council Management Team Employment Opportunities & Internships The American Lupus Society (TALS) Financials ...

  18. El consumo de noticias de los adolescentes chilenos: intereses, motivaciones y percepciones sobre la agenda informativa

    Directory of Open Access Journals (Sweden)

    Ana Rayén Condeza Dall’Orso

    2014-07-01

    Full Text Available En un contexto de proliferación de medios y creciente acceso a diversos contenidos mediáticos, se vuelve necesario examinar las motivaciones de las audiencias jóvenes para consumir información. El estudio de este grupo etario es relevante, dado que la adolescencia es un período fundamental en la socialización cívica de las personas. Esta investigación explora cómo chilenos de 13 a 17 años consumen noticias, en un contexto mediático de múltiples soportes, convergencia y cultura móvil. Pocos estudios se centran en los hábitos informativos de este grupo específico. A partir de un cuestionario cuantitativo autoaplicado en 2013 a 2.273 adolescentes en establecimientos educativos de cuatro regiones del país, se analizan sus hábitos de consumo, interés en las noticias, percepción sobre la importancia de los temas de la agenda y motivaciones informativas. Los resultados muestran que los jóvenes encuestados se informan principalmente a través de redes sociales como Facebook, en detrimento de los medios convencionales. El tema que menos les interesa es la política tradicional, que, a su juicio, es el que más aparece en las noticias. Sus motivaciones en el consumo informativo se relacionan con el deseo de defender sus puntos de vista y de transmitir información a otros. Además, estiman que su representación en la agenda informativa es inadecuada y negativa. Estos resultados sugieren una deuda pendiente de la industria informativa con los jóvenes.

  19. Actividad física y cambios cardiovasculares y bioquímicos del caballo chileno a la competencia de rodeo Physical activity, cardiovascular and biochemical changes of Chilean purebred horses to rodeo competitions

    OpenAIRE

    Perez, R.; Garcia, M.; I. CABEZAS; R. GUZMAN; V. MERINO; Valenzuela, S; Gonzalez, C.

    1997-01-01

    Se realizó un estudio con el objetivo de caracterizar el nivel de esfuerzo físico y la adaptación fisiológica del caballo fina sangre chileno a la competencia de rodeo. Para el estudio se determinaron las medidas hipométricas, se pesaron los jinetes y aperos. Se midió la medialuna en sus diferentes segmentos y se cronometró el tiempo de carrera con el fin de determinar la velocidad de trabajo. Previo y posterior a la primera corrida de cada caballo, se registró la frecuencia cardíaca y se ext...

  20. Lupus Nephritis Susceptibility Loci in Women with Systemic Lupus Erythematosus

    OpenAIRE

    Chung, Sharon A.; Brown, Elizabeth E; Williams, Adrienne H; Ramos, Paula S.; Berthier, Celine C.; Bhangale, Tushar; Alarcon-Riquelme, Marta E; Behrens, Timothy W.; Criswell, Lindsey A.; Graham, Deborah Cunninghame; Demirci, F. Yesim; Jeffrey C Edberg; Gaffney, Patrick M.; Harley, John B.; Jacob, Chaim O.

    2014-01-01

    Lupus nephritis is a manifestation of SLE resulting from glomerular immune complex deposition and inflammation. Lupus nephritis demonstrates familial aggregation and accounts for significant morbidity and mortality. We completed a meta-analysis of three genome-wide association studies of SLE to identify lupus nephritis–predisposing loci. Through genotyping and imputation, >1.6 million markers were assessed in 2000 unrelated women of European descent with SLE (588 patients with lupus nephritis...

  1. Exportando democracia: la implicación española en el plebiscito chileno de 1988

    Directory of Open Access Journals (Sweden)

    Cristina García Gutiérrez

    2015-06-01

    Full Text Available En 1988 Chile se preparaba para un momento trascendental en su futuro político. Según el calendario marcado por la Constitución de 1980, se produciría un plebiscito que iba a decidir el modo que se iba a seguir hasta llegar a una futura transición democrática. Las opciones pasaban por un camino liderado por Augusto Pinochet a través del voto del “sí”, o la oportunidad de realizar elecciones libres a través de la opción del “no”. La coalición de oposición a la dictadura analizó otras experiencias políticas análogas de países que habían atravesado recientemente un proceso político similar. El modelo de transición política española aparecía como un ejemplo en el que fijarse desde Chile. Por su parte, España, a través del gobierno socialista liderado por Felipe González y del resto de partidos políticos del arco parlamentario, tomaron el plebiscito chileno como un proceso propio del que consideraban tenían el deber de tutelar y seguir con detenimiento. La sociedad española tampoco quedó al margen de los sucesos que rodearon al día del plebiscito. A través de diferentes fuentes documentales el presente artículo muestra la naturaleza de esta relación que aunó a los dos contextos políticos explicando los porqués del interés español en el proceso plebiscitario chileno.

  2. Does Lupus Occur in Men?

    Science.gov (United States)

    ... However, there is a connection between impotence or infertility and medications—in particular, cyclophosphamide (Cytoxan®). Before you ... Should I be following a specific diet or nutrition plan for my lupus? Can I treat lupus ...

  3. Lupus anticoagulants and antiphospholipid antibodies

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000547.htm Lupus anticoagulants and antiphospholipid antibodies To use the sharing features on this page, please enable JavaScript. Lupus anticoagulants are antibodies against substances in the lining ...

  4. Políticas Sociales II: El Caso Chileno Políticas Sociales II: El Caso Chileno

    Directory of Open Access Journals (Sweden)

    Osvaldo Larragaña

    1993-03-01

    Full Text Available Políticas Sociales II: El Caso Chileno This article characterizes the Chilean experience with the provision of social services. This is done for social programs in health care, education, monetary subsidies, and nutrition. The article provides a description of the institutional and financial aspects as well as an overall evaluation for each sector.The study of the Chilean case is important in the context of social policy reforms which is emerging in Latin American countries. The importance stems from the fact that maior issues that are being considered in the region -targeting, decentralization, private provision, cost recovery, and demand subsidies- were introduced in Chile more than a decade ago.

  5. Síntomas depresivos y distrés laboral en trabajadores chilenos: condiciones diferenciales para hombres y mujeres

    Directory of Open Access Journals (Sweden)

    Elisa Ansoleaga

    2014-01-01

    Full Text Available El objetivo fue evaluar sintomatología depresiva, asociada a factores de riesgo psicosocial laboral según sexo en Chile, mediante los modelos demanda-control (Karasek y desequilibrio esfuerzo-recompensas (Siegrist. El estudio fue transversal con una muestra aleatoria de 3010 trabajadores asalariados (35% mujeres y 65% hombres de todo el país. Se determinó prevalencias y asociaciones a través de diversas técnicas estadísticas (eg. χ 2 ; regresión logística. La exposición a factores de riesgo psicosocial laboral y la prevalencia de sintomatología depresiva es mayor en mujeres que en hombres (15% vs. 5%. En los análisis ajustados destaca que mujeres expuestas a Isostrain (OR = 2,34; IC95%: 1,42-3,85 y bajas recompensas (OR = 2,13; IC95%: 1,41-3,21, y hombres expuestos a demandas psicológicas (OR = 3,04; IC95%: 1,94-4,76 y desequilibrio esfuerzos-recompensas (OR = 2,19; IC95%: 1,39-3,46, tienen una chance aumentada de sintomatología depresiva al compararse con los no expuestos. La exposición a factores de riesgo psicosocial laboral se asoció con síntomas depresivos en trabajadores chilenos. Resulta clave generar prevención en aspectos de la organización del trabajo.

  6. LAS METAS MÚLTIPLES: ANÁLISIS PREDICTIVO DEL RENDIMIENTO ACADÉMICO EN ESTUDIANTES CHILENOS

    Directory of Open Access Journals (Sweden)

    Leandro Navas Martínez

    2016-01-01

    Full Text Available Este estudio parte de la perspectiva que analiza el contenido de las metas en contextos académicos para explicar la motivación para los estudios. El objeti - vo es analizar la estructura que presentan las metas múltiples en estudiantes chilenos y sus relaciones con el rendimiento académico. Esto implica valorar las cualidades psicométricas del Cuestionario de Metas y valorar la contri - bución de las diferentes metas como variables predictoras del rendimiento académico. Participan 1773 estudiantes de las regiones centro y sur de Chile en las diferentes etapas del sistema educativo, con edades comprendidas en - tre 11 y 50 años. Se analiza la dimensionalidad del instrumento con análisis factoriales, exploratorio y confirmatorio, y se realiza un análisis de regresión múltiple. Surgen tres tipos de metas (sociales, académicas y de responsabili - dad que explican el 20% de la varianza del rendimiento académico. La mayor contribución para predecir el rendimiento de los estudiantes corresponde a las metas académicas. Se derivan implicaciones prácticas y se sugieren líneas de trabajo para futuras investigaciones.

  7. Contraception for adolescents with lupus

    OpenAIRE

    Wagner-Weiner Linda; Gilliam Melissa; Whitaker Amy; Tesher Melissa S; Onel Karen B

    2010-01-01

    Abstract Sexually active adolescents, including young women with lupus, are at high risk for unplanned pregnancy. Unplanned pregnancy among teens with lupus is associated with an elevated risk of poor maternal and fetal outcomes. The provision of effective contraception is a crucial element of care for a sexually-active young woman with lupus. Unfortunately, providers may be hesitant to prescribe contraception to this group due to concerns about increasing the risk of lupus complications. Thi...

  8. Pediatric lupus nephritis: Management update

    OpenAIRE

    SINHA, Rajiv; Raut, Sumantra

    2014-01-01

    Childhood-onset systemic lupus erythematosus (cSLE) is a severe multisystem autoimmune disease. Renal involvement occurs in the majority of cSLE patients and is often fatal. Renal biopsy is an important investigation in the management of lupus nephritis. Treatment of renal lupus consists of an induction phase and maintenance phase. Treatment of childhood lupus nephritis using steroids is associated with poor outcome and excess side-effects. The addition of cyclophosphamide to the treatment sc...

  9. Lupus vulgaris of external nose

    OpenAIRE

    Bhandary, Satheesh Kumar; Ranganna, B. Usha

    2008-01-01

    Lupus vulgaris is the commonest form of cutaneous tuberculosis which commonly involve trunk and buttocks. Lupus vulgaris affecting nose and face, are rarely reported in India. This study reports an unusual case of lupus vulgaris involving the external nose that showed dramatic outcome after six months of anti- tubercular treatment.

  10. Relación entre el síndrome de apnea obstructiva del sueño y el trastorno de déficit atencional con hiperactividad: Estudio en una población de escolares chilenos The relationship between obstructive sleep apnea syndrome and attention deficit hyperactivity disorder: a study in Chilean schoolchildren

    Directory of Open Access Journals (Sweden)

    Carolina Campos O.

    2003-01-01

    Full Text Available Introducción: El síndrome de apnea obstructiva del sueño (SAOS que afecta a 1-2% de los niños, puede ser causa de importante morbilidad, como problemas conductuales y de rendimiento escolar. Objetivo: Evaluar la asociación entre SAOS y Trastorno de Déficit Atencional con Hiperactividad (TDAH en escolares de una comuna de Santiago. Métodos: Se envió una encuesta a 50 padres de niños con diagnóstico de TDAH y a 100 niños controles, de edad y sexo similares, obtenidos de las mismas escuelas de los niños con TDAH. La encuesta incluyó información sobre datos generales, edad, sexo, peso, talla, promedio de notas; y un cuestionario de 12 preguntas para diagnóstico de SAOS, validado previamente en una población extranjera. Resultados: La respuesta de la encuesta fue de 84,6%. No hubo diferencias significativas entre el grupo con TDAH y el grupo control en edad, peso, talla; si las hubo en sexo y promedio de notas (p Introduction: Obstructive sleep apnea syndrome (OSAS affects 1-2% of all children and may cause significant morbidity such as behavioural and learning problems. Objective: To assess the relationship between OSAS and attention deficit hyperactivity disorder (ADHD in children from an area of Santiago, Chile. Method: Questionaires were sent to 50 children with ADHD and 100 children of the same age, gender and attending the same schools, who acted as controls. Information included height, weight, academic performance and 12 questions in order to diagnose OSAS, previously validated in an overseas study. Results: A 84.6% response was obtained, with no significant differences between groups for age, weight, height. However differences were found with respect to gender and academic performance (p < 0.01. The average score in children with ADHD was 9 ± 1.26 and in the controls 6 ± 0.66 (p < 0.05. We found that the answers to the questionaire could differentiate between children with OSAS and normal children. Conclusions: OSAS was

  11. Manifestaciones pulmonares del Lupus Eritematoso Sistémico Pulmonary manifestations of systemic lupus erithematosus

    OpenAIRE

    José Fernando Molina

    1991-01-01

    En esta revisión se describen las diversas manifestacionespulmonares del Lupus Eritematoso Sistémico; se Incluyen tanto los cuadrosrelacionados con la enfermedad (pleuritis con o sin derrame, neumonitis lúpicaaguda, enfermedad intersticlaidifusa, hipertensión pulmonar, disfunción diafragmática,atelectasia y hemorragia pulmonar) como los asociados a ella (infección, edemapulmonar urémico, embolismo pulmonar, neumotórax, pseudolinfoma y sa...

  12. Predictores individuales y familiares de diferentes trayectorias de sintomatología depresiva en adolescentes chilenos

    Directory of Open Access Journals (Sweden)

    Patricio Cumsille

    2015-01-01

    Full Text Available La sintomatología depresiva es prevalente durante la adolescencia, pero no todos los adolescentes experimentan el mismo nivel y evolución de esta sintomatología, lo que sugiere la necesidad de identificar diferencias en las trayectorias de los síntomas. Usando Growth Mixture Modeling analizamos diferentes trayectorias de síntomas depresivos en 1.072 adolescentes chilenos (12-15 años, 54% mujeres, NSE diverso. Primero, se seleccionó un modelo basal y luego se utilizó la irritabilidad del adolescente, la calidez, demanda y falta de respeto de la madre como predictores de la pertenencia a las clases. Se seleccionó un modelo con cuatro clases latentes de síntomas depresivos: alta persistente (12%, baja estable (56%, decreciente (15% y creciente (17%. La clase baja estable fue la más prevalente y se caracterizó por alto nivel de calidez maternal y bajo nivel de falta de respeto materna e irritabilidad del adolescente, en tanto que la clase alta persistente presentó características opuestas (baja calidez y alta demanda materna e irritabilidad del adolescente. Se observaron diferencias en la prevalencia de clases por sexo. Estos resultados resaltan la importancia de identificar diferentes trayectorias de síntomas depresivos y sus predictores. La asociación entre las dimensiones parentales y las trayectorias de síntomas depresivos persistentes provee evidencia de que los comportamientos parentales pueden servir, tanto como factores protectores como de riesgo.

  13. Psoriasiform lupus vulgaris.

    Science.gov (United States)

    Padmavathy, L; Rao, L Lakshmana; Ethirajan, N; Dhanlaklshmi, M

    2008-04-01

    Tuberculosis is a major public health problem in both developing and developed countries. Cutaneous Tuberculosis constitutes a minor proportion of extra-pulmonary manifestations of Tuberculosis. Lupus Vulgaris (LV) is one of the clinical variants of Cutaneous Tuberculosis. A case of a large plaque type psoriasiform lesion of lupus vulgaris on the thigh, of 15 years' duration, in an 18-year-old girl is reported. This case highlights the ignorance level among the patients and consequent failure to avail proper anti-tuberculous treatment despite campaign in print and audio visual media. PMID:18516827

  14. Ectopic Axillary Breast during Systemic Lupus

    OpenAIRE

    2012-01-01

    Many breast changes may occur in systemic lupus erythematosus. We report a 41-year-old woman with lupus who presented three years after the onset of lupus an ectopic mammary gland confirmed by histological study.

  15. Ectopic Axillary Breast during Systemic Lupus

    Directory of Open Access Journals (Sweden)

    Besma Ben Dhaou

    2012-01-01

    Full Text Available Many breast changes may occur in systemic lupus erythematosus. We report a 41-year-old woman with lupus who presented three years after the onset of lupus an ectopic mammary gland confirmed by histological study.

  16. CORTE TRANSVERSAL DE LOS RETORNOS ESPERADOS EN EL MERCADO ACCIONARIO CHILENO

    OpenAIRE

    Fernando Rubio

    2004-01-01

    La presente investigación intenta replicar el trabajo de Fama y French (1992) para el mercado chileno, dentro de cierto marco de limitaciones generales. Específicamente, el objetivo de la investigación es evaluar el rol conjunto del beta de mercado, el tamaño, la razón utilidad a precio, el leverage y la razón bolsa a libro en la explicación de corte transversal de los retornos promedios de las acciones en el mercado bursátil chileno. El estudio consta de tres partes: La primera presenta la e...

  17. Systemic Lupus Erythematosus

    Science.gov (United States)

    ... immune system known as autoimmune diseases. In autoimmune diseases, the immune system turns against parts of the body it ... and organs are affected, and the severity of disease. In lupus, the body’s immune system does not work as it should. A ...

  18. Kutan lupus erythematosus

    DEFF Research Database (Denmark)

    Sandreva, Tatjana; Voss, Anne; Bygum, Anette

    2016-01-01

    Cutaneous lupus erythematosus (LE) is an autoimmune disease. The most common clinical forms are acute cutaneous LE (ACLE), subacute cutaneous LE (SCLE) and discoid LE (DLE). Cutaneous LE, mainly ACLE, can be the first sign of systemic LE (SLE). DLE and SCLE are less associated with development of...

  19. Lupus induced by medicaments

    International Nuclear Information System (INIS)

    We describe a 55 years old female patient who consulted by fever syndrome, artralgias and the presence of high tittles positives antinuclear antibodies. She had arterial hypertension in treatment with captopril. We suspected the clinical diagnoses of drug-induced lupus; the withdraw of captopril was associated with the remission of the clinical and laboratory manifestations

  20. Lupus vulgaris on keloid

    Directory of Open Access Journals (Sweden)

    Jena S

    2002-01-01

    Full Text Available A 28-year-old man presented with multicentric lupus vulgaris on keloids over chest, axilla, neck and back for last 6 months. He had pulmonary tuberculosis. All the laboratory investigations were in favour of clinical diagnosis. The patient responded to antituberculosis therapy.

  1. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Finances? Do You Have Legal Authority to Make Decisions? Become Familiar With Your Loved One’s Health Insurance ... 15 Questions - Disability: Working Your Way Through the System 15 Questions - Back to School with ... effects, and an introduction to some of the information and support services available from the Lupus Foundation ...

  2. Target Awareness: Lupus

    Medline Plus

    Full Text Available ... Q&A with Cindy Coney - Dealing with Holiday Stress Q&A with Dr. Victoria Werth - Photosensitivity in ... Q&A with Ms. Cindy Coney - Lupus and Stress Q&A with Dr. Ronenn Roubenoff - Nutrition and ...

  3. Kidney disease in lupus is not always 'lupus nephritis'

    OpenAIRE

    Anders, Hans-Joachim; Weening, Jan

    2013-01-01

    textabstractIn lupus erythematosus, elevated serum creatinine levels and urinary abnormalities implicate a kidney disorder, which may not always be lupus nephritis as defined by the current classification of the International Society of Nephrology/Renal Pathology Society. The signs of renal dysfunction may be caused by lupusunrelated renal injury such as drug toxicity or infection or by lupus-associated mechanisms that are not part of the classification, such as minimal change nephrotic syndr...

  4. Lupus eritematoso discóide na infância Discoid lupus erythematosus in childhood

    OpenAIRE

    Maria Carolina de A. Sampaio; Clovis Artur A Silva; Pereira, Rosa Maria R.; Zilda Najjar P. de Oliveira

    2007-01-01

    OBJETIVO: Realizar revisão da literatura sobre o lupus eritematoso discóide (LED) na infância. FONTES DE DADOS: Livros-texto e artigos de revistas indexadas pelo Medline e SciELO nos últimos dez anos, usando as seguintes palavras-chave: "discoid lupus erythematosus", "chronic cutaneous lupus erythematosus", "lupus erythematosus in childhood", "lupus erythematosus in children", "discoid lupus erythematosus in childhood", "discoid lupus erythematosus in children". SÍNTESEDOS DADOS: A idade de i...

  5. Contraception for adolescents with lupus

    Directory of Open Access Journals (Sweden)

    Wagner-Weiner Linda

    2010-03-01

    Full Text Available Abstract Sexually active adolescents, including young women with lupus, are at high risk for unplanned pregnancy. Unplanned pregnancy among teens with lupus is associated with an elevated risk of poor maternal and fetal outcomes. The provision of effective contraception is a crucial element of care for a sexually-active young woman with lupus. Unfortunately, providers may be hesitant to prescribe contraception to this group due to concerns about increasing the risk of lupus complications. This article reviews the risks and benefits of currently-available contraceptives for young women with lupus. Providers are encouraged to consider long-term, highly-effective contraception, such as implantables and intrauterine devices, for appropriately selected adolescents with lupus.

  6. Teatro chileno y anarquismo (desde comienzos de siglo XX hasta el período dictatorial) Chilean Theatre and Anarchism (from the beginning of 20th century to the dictatorship)

    OpenAIRE

    Sara Rojo

    2008-01-01

    Este estudio analiza la relación entre el pensamiento anarquista y el teatro en Chile desde comienzos de siglo hasta el período de la dictadura militar. Comienza con un recorte teórico del concepto de anarquismo dentro del marco histórico chileno, para posteriormente analizar, de manera cronológica, producciones teatrales específicas del período anteriormente citado.This study analyzes the relationship between anarchist thinking and theatre in Chile from the beginning of the century up to the...

  7. RESPUESTA DE DOS AISLAMIENTOS CHILENOS DE Metarhizium anisopliae (METSCHNIKOFF) SOROKIN A LA ADICIÓN DE UN PROTECTOR SOLAR Response of two Chilean Metarhizium anisopliae (Metschnikoff) Sorokin isolates to the addition of a solar sunscreen

    OpenAIRE

    Luis Devotto M.; Marcos Gerding P

    2003-01-01

    Dos aislamientos chilenos de Metarhizium anisopliae (Metchsnikoff) Sorokin fueron expuestos a dosis crecientes de luz ultravioleta (UV), en condiciones de laboratorio. Conidias en suspensión acuosa fueron esparcidas en placas Petri con agar y éstas fueron puestas bajo una lámpara de luz UV-C (lambda = 254 nm). Sin el protector solar, la exposición de las conidias durante 40 s redujo su germinación de 80-95% a sólo 5-2%, para QU-M221b y QU-M363, respectivamente. Usando el protector solar Blank...

  8. Kidney disease in lupus is not always 'lupus nephritis'

    NARCIS (Netherlands)

    H.J. Anders (Hans-Joachim); J.J. Weening (Jan)

    2013-01-01

    textabstractIn lupus erythematosus, elevated serum creatinine levels and urinary abnormalities implicate a kidney disorder, which may not always be lupus nephritis as defined by the current classification of the International Society of Nephrology/Renal Pathology Society. The signs of renal dysfunct

  9. Incidence of systemic lupus erythematosus and lupus nephritis in Denmark

    DEFF Research Database (Denmark)

    Hermansen, Marie-Louise F.; Lindhardsen, Jesper; Torp-Pedersen, Christian;

    2016-01-01

    OBJECTIVE: To determine the incidence of systemic lupus erythematosus (SLE) and SLE with concomitant or subsequent lupus nephritis (LN) in Denmark during 1995-2011, using data from the Danish National Patient Registry (NPR). METHODS: To assess the incidence of SLE, we identified all persons aged...

  10. El significado de la histerectomía para un grupo de hombres chilenos parejas de histerectomizadas

    Directory of Open Access Journals (Sweden)

    Alejandra Araya Gutiérrez

    2012-12-01

    Full Text Available Se objetivó conocer el significado de la histerectomía para un grupo de hombres chilenos, parejas de mujeres histerectomizadas (HPMH. Estudio cualitativo, con entrevistas en profundidad realizadas a 15 hombres, parejas de mujeres histerectomizadas, entre Mayo y Septiembre del 2010, previa aprobación de dos Comités de Ética. Para el análisis de los datos se utilizó la perspectiva fenomenológica descrita por Giorgi, y se realizó el análisis de contenido según Krippendorff. Los criterios de Creswell fueron utilizados para evaluar la credibilidad del análisis y asegurar la validez descriptiva. Emergieron cinco dimensiones que representan aspectos únicos del significado de la histerectomía para los hombres parejas de mujeres histerectomizadas: síntomas, comentarios, atributos del útero, preocupaciones, y cambios en la sexualidad. Educar los hombres parejas de mujeres histerectomizadas es una acción fundamental para apoyar a las mujeres que serán sometidas a una histerectomía, siendo necesaria su incorporación en el plan de cuidados de ellas.

  11. THE CAROLINA LUPUS STUDY (CLU)

    Science.gov (United States)

    Carolina Lupus (CLU) Study, an epidemiologic study of risk factors for systemic lupus erythematosus (SLE). SLE is a severe, chronic, systemic autoimmune disease that disproportionately affects women and African-Americans. The CLU Study focuses on measures of endogenous hormone ex...

  12. Prognostic factors in lupus nephritis

    DEFF Research Database (Denmark)

    Faurschou, Mikkel; Starklint, Henrik; Halberg, Poul;

    2006-01-01

    To evaluate the prognostic significance of clinical and renal biopsy findings in an unselected cohort of patients with systemic lupus erythematosus (SLE) and nephritis.......To evaluate the prognostic significance of clinical and renal biopsy findings in an unselected cohort of patients with systemic lupus erythematosus (SLE) and nephritis....

  13. Headache in Systemic Lupus Erythematosus

    DEFF Research Database (Denmark)

    Hanly, John G; Urowitz, Murray B; O'Keeffe, Aidan G;

    2013-01-01

    To examine the frequency and characteristics of headaches and their association with global disease activity and health-related quality of life (HRQOL) in patients with systemic lupus erythematosus (SLE).......To examine the frequency and characteristics of headaches and their association with global disease activity and health-related quality of life (HRQOL) in patients with systemic lupus erythematosus (SLE)....

  14. Fatigue in systemic lupus erythematosus

    OpenAIRE

    Ahn, Grace E.; Ramsey-Goldman, Rosalind

    2012-01-01

    Systemic lupus erythematosus is a chronic inflammatory autoimmune disease often characterized by fatigue, with significant effects on physical functioning and wellbeing. The definition, prevalence and factors associated with fatigue, including physical activity, obesity, sleep, depression, anxiety, mood, cognitive dysfunction, vitamin D deficiency/insufficiency, pain, effects of medications and comorbidities, as well as potential therapeutic options of fatigue in the systemic lupus erythemato...

  15. DURACION DE LA ESTADIA HOSPITALARIA POR NEUMONIA COMUNITARIA CON LA APLICACION RIGUROSA DEL CONSENSO CHILENO 2005.

    Directory of Open Access Journals (Sweden)

    Dr Luis Sanhueza A.

    2007-12-01

    Full Text Available INTRODUCTION: Community adquired pneumonia (CAP isan acute respiratory infection prevalent in our country. Ourgoal is to evaluate impact of national guideline implementation(Chilean CAP consensus 2005, in patients diagnosed with CAPGroup 3 (G3, in terms of the clinical evolution and hospitalizationtime among others variables assessed. For this purposeclinical records from the Medicine Service of the Yumbel Hospitalwere reviewed, between January 2006 and March 2007.

  16. Bullying y calidad de vida relacionada con la salud en adolescentes escolares chilenos

    Directory of Open Access Journals (Sweden)

    Carlos Hidalgo-Rasmussen

    2015-06-01

    Full Text Available Background: Bullying has a negative impact on the perception of adolescents of their quality of life. Aim: To analyze the association between being bullied and health related quality of life in Chilean adolescents. Material and Methods: The bullying module of the KIDSCREEN 52 survey and the KIDSCREEN 10 survey to assess health related quality of life were applied to 7737 students aged 10 to 18 years. Social and demographic data, information about disability and type of school were also gathered. Results: Fifteen percent of surveyed students were bullied. A lower quality of life perception increased by a factor of 2.6 among bullied students. It also increased by a factor of 4.4 among students with a low self-esteem, by a factor of 3.1 among those who perceived their health status as regular or bad and by a factor of 1.4 among women. Conclusions: Bullying is associated with a lower quality of life perception among Chilean students.

  17. A rare case of transition to membranous lupus nephritis from diffuse proliferative lupus nephritis

    OpenAIRE

    Nishi, Hitomi; Sugimoto, Keisuke; FUJITA, Shinsuke; Miyazawa, Tomoki; Enya, Takuji; Izu, Akane; Wada, Norihisa; Okada, Mitsuru; Takemura, Tsukasa

    2014-01-01

    [Abstract] Lupus nephritis is an important complication of systemic lupus erythematosus (SLE) that affects the prognosis. A rare type of lupus nephritis, class V, shows histological findings resembling those of membranous nephropathy. While most diffuse proliferative lupus nephritis is associated with other SLE disease activity, class V lupus nephritis can occur without systemic activity. Furthermore, Class V is less responsive to steroid therapy than other forms of lupus nephritis. We treate...

  18. Melanotic lupus erythematosus: A rare variant of discoid lupus erythematosus

    Directory of Open Access Journals (Sweden)

    Seval Doğruk Kaçar

    2015-03-01

    Full Text Available Discoid lupus erythematosus (DLE is characterized by atrophic patches with peripheral hyperpigmentation on sun exposed skin areas. It rarely presents with diffuse hyperpigmented patches without erythema, adherent scale and atrophy on face and neck. This presentation is called as melanotic lupus erythematosus and it is rarely reported in literature. Other diseases that cause facial pigmentation as melasma, Riehl melanosis, lichen planus pigmentosus, drug related pigmentation should be considered in the differential diagnosis. We herein report a 66 year old male patient with diffuse blue-brown pigmentations on his face which was diagnosed as melanotic lupus erythematosus with the clinical, histopathological and immunofluoresence findings.

  19. Separatismo o participación: Evangélicos chilenos frente a la Política

    Directory of Open Access Journals (Sweden)

    Evguenia Fediakova

    2002-01-01

    Full Text Available En la etapa actual de la modernidad, la religión vuelve a ser uno de los factores determinantes en la política mundial y relaciones internacionales. Los fenómenos religiosos influyen en las transformaciones culturales, en las percepciones y maneras de construir las imágenes del amigo y enemigo, lo que afecta indirectamente al proceso de toma de decisiones, elaboración de la política exterior o resolución de conflictos. Hoy en día el movimiento evangélico de Chile se consolida cada vez más como un nuevo protagonista de la sociedad civil. Tras romper la marginalidad social y simbólico-espiritual, el mundo evangélico chileno experimenta importantes procesos de modificación que afectan su identidad religiosa y sus relaciones con la sociedad, produciendo distintas formas de reacción a los nuevos desafíos políticosociales. Los imperativos de establecer una vinculación más estrecha con la sociedad y la creciente autoconciencia como una importante fuerza social y electoral, avalan por una parte, los intentos de constituirse como un nuevo actor político y, por otra, ponen al movimiento evangélico frente a nuevos desafíos prácticos y teológicos, en busca de una mayor adecuación entre su misión evangelizadora y retos de la modernidad

  20. Vulnerabilidad social y conductas sexuales de riesgo en un grupo de adolescentes chilenos, 2009: Estudio de corte transversal

    Directory of Open Access Journals (Sweden)

    Ruth Pérez-Villegas

    2012-12-01

    Full Text Available Objetivo: analizar la relación entre vulnerabilidad social y conductas sexuales de riesgo en un grupo de adolescentes chilenos. Materiales y métodos: estudio transversal en adolescentes de la comuna Chiguayante, región del Bío-Bío, Chile, año 2009. La muestra fue de 297 adolescentes, 154 mujeres y 143 varones. Se utilizó la ficha CLAP OPS/OMS y un instrumento de vulnerabilidad social y conducta sexual. Se aplicó t-Student y Ji 2 (p < 0,05. Resultados: la edad promedio fue 16,5 ± 1,5 años en varones y 16,4 ± 1,5 mujeres. El 63% vive con ambos padres. El 74% describe sus relaciones familiares como buenas y excelentes. El 44% de los adolescentes que han iniciado actividad sexual definen sus relaciones familiares como regulares, malas o sin relación frente al 20% que no ha iniciado actividad sexual (p = 0,033; el 62% de los adolescentes que han iniciado actividad sexual percibe escaso o nulo apoyo familiar frente al 42% de los adolescentes que no han iniciado actividad sexual (p = 0,0031. El 51% señala que hay delincuencia en su entorno social próximo. No hubo diferencias significativas al asociar variables de vulnerabilidad social con uso de métodos anticonceptivos y el número de parejas sexuales. Las relaciones sexuales asociadas al consumo de alcohol y drogas fueron superiores en varones (21% que en mujeres (10% (p = 0,019; las relaciones sexuales sin protección fueron superiores en mujeres (35% que en varones (20% (p = 0,05. Conclusión: se reconoce la importancia de la familia en el proceso de formación de la conducta sexual de las y los adolescentes.

  1. Los Orígenes de la Jurisdicción Arbitral en el Derecho de Aguas Chileno

    Directory of Open Access Journals (Sweden)

    Iván Mauricio Obando Camino

    2005-01-01

    Full Text Available Este artículo trata acerca de los orígenes de la jurisdicción arbitral en el derecho de aguas chileno. El autor sostiene que el origen de esta jurisdicción se remonta a los estatutos de la Sociedad del Canal de Maipo, dictados entre 1827 y 1831. Ella fue confirmada por la Excma. Corte Suprema en la causa «Donato Millán con Sociedad del Canal de Maipo», de 1888. El legislador se inspiró en los estatutos de dicha sociedad para dictar la L. N° 2139, de 1908, sobre Asociaciones de Canalistas, la que fue elaborada por el abogado de aquélla, don Carlos Aldunate Solar. La Excma. Corte Suprema dio su fisonomía definitiva a esa jurisdicción en la causa «Marx y otro con Asociación de Canalistas del Río Huasco», de 1945, en la que declaró que el directorio de una asociación de canalistas no podía conocer de juicios declarativos de derechos de agua.This article deals about the origins of arbitral jurisdiction in the Chilean water law. The author maintains that the origins of this jurisdiction go back to the by-laws of the Maipo Channel Society, enacted from 1827 through 1831. The judiciary confirmed this jurisdiction in the 1888 case "Donato Millán vs. Maipo Channel Society". The legislature took the Maipo Channel Society as a model to pass the 1908 Act N° 2139, on Water Channels Owners Associations, drafted by Mr. Carlos Aldunate Solar, the counselor of the society. The Chilean Supreme Court gave its definite meaning to that jurisdiction in the 1945 case "Marx and another vs. Water Channel Association of the Huasco River" wherein it stated that the association board could not adjudicate on the existence of water law rights.

  2. VV.AA, Encuentro chileno de editores independientes. Propósitos y experiencias

    Directory of Open Access Journals (Sweden)

    Lorena Fuentes

    2013-07-01

    Full Text Available RESEÑA BIBLIOGRÁFICA. "VV.AA, Encuentro chileno de editores independientes. Propósitos y experiencias", Gladys González y Felipe Moncada Mijic (Editores, Santiago de Chile y Ediciones Inubicalistas, 2012, 178 p. (Formato impresoEl siguiente texto es un comentario al libro Encuentro chileno de editores independientes, que recoge la experiencia del evento homónimo celebrado en Valparaíso durante agosto y septiembre del 2012. A partir de una breve introducción que busca situar al fenómeno de la edición independiente en nuestro campo cultural, esta nota reflexiona sobre los elementos de interés que esta publicación ofrece a quienes buscan profundizar su conocimiento sobre esta práctica editorial.

  3. LA ESTRATEGIA DE CITICORP EN CHILE. Capitulo 3. EL MERCADO FINANCIERO CHILENO

    OpenAIRE

    Fernando Rubio

    2004-01-01

    Esta es la tercera parte de una serie que forman una investigación más amplia titulada “La Estrategia de Citicorp en Chile: Un Intento de Investigación”. Aquí se describe la naturaleza, reglamentación, estado actual y perspectivas de más de los 25 segmentos del mercado financiero chileno, desde la banca hasta las administradoras de fondos de pensiones.

  4. El Movimiento estudiantil chileno y el proceso de reforma universitaria, 1967-1968

    DEFF Research Database (Denmark)

    Cancino, Hugo

    2012-01-01

    En la presente ponencia analizamos el contexto histórico y cultural del movimiento de reforma de la Universidad de Chile, 1967-68 y su gestación en la Facultad de Filosofía y Educación. Este movimiento que se inscribió en la dilatada tradición de lucha de los estudiantes chilenos y latinoamericanos...

  5. Lupus Erythematosus Panniculitis in Pregnancy

    OpenAIRE

    Swati Gondane; Rajkumar Kothiwala; Sapna Dangi; Ashok Meherda

    2015-01-01

    A case of lupus erythematosus (LE) panniculitis in pregnancy without any lesions of discoid LE or systemic LE is being reported. There were no systemic symptoms. Her ANA, anti-dsDNA, anti-Ro/SSA, and anti-La/SSB antibodies were within normal limits. Diagnosis of lupus panniculitis was considered on clinical and histopathological grounds. The condition responded favorably to systemic steroid therapy.

  6. Managing lupus patients during pregnancy

    OpenAIRE

    Lateef, Aisha; Petri, Michelle

    2013-01-01

    Systemic lupus erythematosus (SLE) is an autoimmune disease, primarily affecting young females. Pregnancy in a woman with SLE remains a high risk situation with higher maternal and fetal mortality and morbidity. Although live births are achieved in majority of the pregnancies, active disease and major organ involvement can negatively affect the outcomes. Higher risk of fetal loss, pre-term birth, intra-uterine growth restriction and neonatal lupus syndromes are major fetal issues. Mothers are...

  7. Lupus erythematosus panniculitis in pregnancy

    Directory of Open Access Journals (Sweden)

    Swati Gondane

    2015-01-01

    Full Text Available A case of lupus erythematosus (LE panniculitis in pregnancy without any lesions of discoid LE or systemic LE is being reported. There were no systemic symptoms. Her ANA, anti-dsDNA, anti-Ro/SSA, and anti-La/SSB antibodies were within normal limits. Diagnosis of lupus panniculitis was considered on clinical and histopathological grounds. The condition responded favorably to systemic steroid therapy.

  8. Genetic epidemiology: Systemic lupus erythematosus

    OpenAIRE

    Ahmad, Yasmeen A.; Bruce, Ian N.

    2001-01-01

    Systemic lupus erythematosus is the prototype multisystem autoimmune disease. A strong genetic component of susceptibility to the disease is well established. Studies of murine models of systemic lupus erythematosus have shown complex genetic interactions that influence both susceptibility and phenotypic expression. These models strongly suggest that several defects in similar pathways, e.g. clearance of immune complexes and/or apoptotic cell debris, can all result in disease expression. Stud...

  9. Epratuzumab for systemic lupus erythematosus.

    Science.gov (United States)

    Wallace, D J; Goldenberg, D M

    2013-04-01

    Epratuzumab (EMab, UCB, Immunomedics) is a humanized monoclonal antibody targeting CD22 that is being studied in clinical trials for patients with a variety of rheumatic and hematologic conditions, including systemic lupus erythematosus (SLE). An overview of its mechanism of action is followed by a summary of completed lupus studies, and a preview of studies in progress. The agent clearly has anti-inflammatory activity and is a potentially useful agent in the management of autoimmune disorders. PMID:23553783

  10. La ansiedad escénica en intérpretes musicales chilenos

    Directory of Open Access Journals (Sweden)

    Mimí Marinovic

    2006-06-01

    Full Text Available La ansiedad escénica (AE es uno de los mayores problemas del ejercicio profesional de los intérpretes musicales. Encuestas realizadas en países desarrollados revelan cifras de prevalencia entre 24% -70% y citan casos severos, causantes del abandono de la carrera. Objetivos: detectar la prevalencia de la AE en músicos chilenos que desempeñan su profesión en los principales conjuntos de música de concierto y determinar algunos de los factores que, a su juicio, influyen en su aparición. Método: 249 intérpretes (122 instrumentistas, 26 directores y 101 cantantes respondieron un cuestionario autoaplicado, incluido en una investigación más amplia sobre los intérpretes de arte. Este instrumento fue complementado con 36 entrevistas abiertas (13 instrumentistas, 6 directores y 11 cantantes. Resultados: el 78% de los músicos estudiados admitió haber sufrido AE, más mujeres que varones. El 64% consideró que ella se relaciona principalmente con la tarea a ejecutar (preparación insuficiente, dificultad de la obra, mientras que el 32% lo atribuyó a factores personales (ser nervioso, temor al fracaso y sólo el 4% a factores situacionales. Hubo diferencias significativas por género, especialidad y edad. Las entrevistas permitieron profundizar acerca del alcance de estos resultados. Conclusiones: se constató una alta prevalencia de AE, la cual debiera ser abordada interdisciplinariamente por especialistas de la salud mental y la música en beneficio de la educación general, la formación especializada y el desarrollo profesional de los intérpretes musicalesPerformance anxiety (PA is one of the major problems that musicians face in their careers. Surveys carried out in developed countries show prevalence figures ranging 24% -70% and quote severe cases leading to abandonment of the profession. Objectives: detect the prevalence of PA in Chilean musicians working in the main groups of concert music and determine some of the factors that

  11. "Bound" globulin in the skin of patients with chronic discoid lupus erythematosus and systemic lupus erythematosus

    NARCIS (Netherlands)

    Cormane, R.H.

    1964-01-01

    In what respect chronic discoid lupus erythematosus is related to systemic lupus erythematosus is still uncertain. In discoid lupus the lupus-erythematosus (L.E.) phenomenon is negative, and the history does not suggest vascular lesions or involvement of serous membranes. In both diseases the pathog

  12. 75 FR 35492 - Guidance for Industry on Lupus Nephritis Caused By Systemic Lupus Erythematosus-Developing...

    Science.gov (United States)

    2010-06-22

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry on Lupus Nephritis Caused By Systemic... availability of a guidance for industry entitled ``Lupus Nephritis Caused By Systemic Lupus Erythematosus... nephritis (LN) caused by systemic lupus erythematosus (SLE). This guidance finalizes the parts of the...

  13. Lupus a Tough Disease to Spot, Treat

    Science.gov (United States)

    ... nlm.nih.gov/medlineplus/news/fullstory_159098.html Lupus a Tough Disease to Spot, Treat But experts ... 30, 2016 MONDAY, May 30, 2016 (HealthDay News) -- Lupus is difficult to diagnose and treat, but scientists ...

  14. Lupus, discoid on a child's face (image)

    Science.gov (United States)

    The round or disk shaped (discoid) rash of lupus produces red, raised patches with scales. The pores ( ... The majority (approximately 90%) of individuals with discoid lupus have only skin involvement as compared to more ...

  15. Seizures associated with Lupus during pregnancy

    OpenAIRE

    Aoki, Shigeru; KOBAYASHI, Natsuko; Mochimaru, Aya; Takahashi, Tsuneo; Hirahara, Fumiki

    2016-01-01

    Key Clinical Message A sudden flare of previously stable SLE may give rise to CNS lupus. During pregnancy, seizures associated with CNS lupus can cause hypoxic‐ischemic encephalopathy (HIE) in the infant.

  16. Lupus cystitis with hydroureteronephrosis in a young female with lupus nephritis

    OpenAIRE

    Tony Ete; Sumantro Mondal; Debanjali Sinha; Soumik Sarkar; Abhirup Bhunia; Shingamlung Kamei; Jyotirmoy Pal; Alakendu Ghosh

    2014-01-01

    Systemic lupus erythematosus is an autoimmune, multisystem disorder. Lupus nephritis is a common manifestation of SLE. Though rare, SLE may also involve lower urinary tract in the form of lupus cystitis with associated complications like hydroureteronephrosis. Lupus cystitis may present with gastro intestinal (GI) symptoms as the initial manifestation. The case reported herein is concerned with concomitant lupus nephritis and cystitis in a young female who also had associated GI symptoms and ...

  17. Lupus and Pregnancy: Complex Yet Manageable

    OpenAIRE

    Dhar, Josephine Patricia; Robert J. Sokol

    2006-01-01

    Systemic lupus erythematosus is a chronic multi-system autoimmune disease that occurs predominantly in women of childbearing age. The risk of complications and adverse fetal outcomes in pregnant women with lupus is high. Moreover, pregnancy can cause flares of lupus disease activity necessitating maternal immunosuppressive intervention. Interestingly, many potential complications of pregnancy present as symptoms of lupus making diagnosis and treatment a challenge.Advancing technology and bett...

  18. Clinical profile of patients with lupus nephritis

    OpenAIRE

    A.C. Schönrock; T.L. Skare

    2011-01-01

    To the Editor Lupus nephritis is the strongest predictor of systemic lupus erythematosus (SLE) patient’s morbidity and mortality with a prevalence varying from 31 to 65% according to the studied population (1). As the onset of lupus nephritis is usually silent, knowing possible association with others symptoms is useful in order to keep of better vigilance on patients with higher possibility to develop it. Pistiner et al described that lupus patients with nephritis also have an increased freq...

  19. Mechanisms of tissue injury in lupus nephritis

    OpenAIRE

    Tamara K Nowling; Gilkeson, Gary S.

    2011-01-01

    Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major cause of morbidity and mortality in patients with lupus, occurs in approximately 50% of lupus patients. In the present review, we provide an overview of the current research and knowledge concerning mechanisms of renal injury in both lupus...

  20. An unusual presentation of juvenile lupus nephritis

    OpenAIRE

    Malleshwar Bottu; Manjusha Yadla; Srikanth Burri; Megha Uppin

    2016-01-01

    The incidence of juvenile lupus varies widely ranging between 4 and 250 per 100,000 population. Most common organ involvement in juvenile lupus is kidney. Neurological, cutaneous and hematological involvements are also involved. Skeletal muscle involvement in the form of myositis is rare. Myositis as presenting manifestation in juvenile lupus is also unusual. Herein, we report one such case wherein myositis preceded the onset of lupus nephritis

  1. The Clinicopathological Study of Lupus Nephritis

    OpenAIRE

    Raouf Rahim Merza; Ayar Omer Ali; Hawar Ali Ehsan Kaka Khan

    2014-01-01

    Purpose: Lupus nephritis is one of the most serious manifestations of Systemic lupus erythematosis and it is a major cause of morbidity and mortality. The aim of this study is to compare males and females in lupus nephritis presentations. Material and Methods: A cross-sectional study performed on forty five patients with biopsy proven Lupus Nephritis including 32 females and 13 males. All patients assessed by questionnaire form and investigated for hematological, biochemical, immunologica...

  2. An unusual presentation of juvenile lupus nephritis

    Directory of Open Access Journals (Sweden)

    Malleshwar Bottu

    2016-01-01

    Full Text Available The incidence of juvenile lupus varies widely ranging between 4 and 250 per 100,000 population. Most common organ involvement in juvenile lupus is kidney. Neurological, cutaneous and hematological involvements are also involved. Skeletal muscle involvement in the form of myositis is rare. Myositis as presenting manifestation in juvenile lupus is also unusual. Herein, we report one such case wherein myositis preceded the onset of lupus nephritis

  3. Topical calcineurin inhibitors in systemic lupus erythematosus

    OpenAIRE

    Lampropoulos, Christos

    2010-01-01

    Christos E Lampropoulos, David P D’CruzLupus Research Unit, Rayne Institute, St. Thomas’ Hospital, London, UKAbstract: Cutaneous lupus erythematosus (CLE) encompasses a variety of lesions that may be refractory to systemic or topical agents. Discoid lupus erythematosus (DLE) and subacute cutaneous lupus erythematosus (SCLE) are the most common lesions in clinical practice. The topical calcineurin inhibitors, tacrolimus and pimecrolimus, have been used to treat resistant cu...

  4. Chilblain lupus erythematosus in an adolescent girl

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    Shikha Bansal

    2014-01-01

    Full Text Available Chilblain Lupus Erythematosus (CHLE is a rare form of cutaneous lupus erythematosus (LE, more frequently seen in middle aged females. It is characterized by erythematous to violaceous plaques over the acral areas induced by exposure to cold or drop in temperature unlike lesions of lupus erythematosus that worsen with sun exposure. Here, we present a case of chilblain lupus erythematosus in an adolescent girl with few unique features not previously reported.

  5. Lupus of the upper respiratory tract

    OpenAIRE

    P. Pandey; Shukla, G. K.

    2006-01-01

    Lupus is a form of chronic tuberculous infection which can be differentiated from tuberculosis only on clinical grounds. Lupus is very rarefy found in the present era. A 10 year mule child was diagnosed as a case of lupus on clinical and pathological examination

  6. LUPUS ERITEMATOSO SISTÉMICO SÍNDROME DE CUSHING Y PSIQUIATRÍA DE ENLACE Erythematous systemic lupus, Cushing`s syndrome and psychiatric

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    Ludwig Pájaro Silva

    2005-04-01

    Full Text Available Se presenta el caso de una paciente con diagnóstico de lupus eritematoso sistémico y síndrome de Cushing quien presentó síntomas afectivos de características depresivas e insomnio de conciliación, quien recibió múltiples tratamientos farmacológicos con pobre respuesta inicial. La psiquiatría de enlace consolida una alternativa de tratamiento multidisciplinario para una aproximación más eficiente a las patologías médicas con síntomas psiquiátricos.We present a case of systemic erythematosus lupus and Cushing's syndrome who has affective symptoms of depressive characteristic and insomnia and multiple pharmacological treatments with poor response. The intervention by psychiatry liaison is an alternative of multidisciplinary treatment for an efficient approximation of medical pathologies with psychiatric symptoms.

  7. Factores de riesgo cardiovascular en estudiantes universitarios chilenos

    OpenAIRE

    Chiang-Salgado María Teresa; Casanueva-Escobar Víctor; Cid-Cea Ximena; González-Rubilar Urcesino; Olate-Mellado Paola; Nickel-Paredes Fabiola; Revello-Chiang Leandro

    1999-01-01

    OBJETIVO: Evaluar la prevalencia de factores de riesgo cardiovascular en universitarios asintomáticos de ambos sexos, de entre 18 y 25 años de edad. MATERIAL Y MÉTODOS: La muestra quedó integrada por 1 301 estudiantes. En una submuestra de 293 sujetos se midieron lípidos séricos, con un analizador químico Hitachi 717. La obesidad se estimó considerando el índice de masa corporal (IMC); el antecedente familiar de infarto, así como el consumo de cigarrillos y el nivel de actividad física se det...

  8. Connectedness Among Chilean Adolescents: Factor Analysis of the Hemingway Measure of Adolescent Connectedness La Conectividad Entre Adolescentes Chilenos: Un Análisis Factorial de la Hemingway Measure of Adolescent Connectedness

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    Benedict T McWhirter

    2011-05-01

    Full Text Available The construct of connectedness was investigated among 390 Chilean adolescents using the Hemingway Measure of Adolescent Connectedness (Hemingway; Karcher, 2003. Participants were 7th-12th graders at an urban Santiago Catholic school. Results of a principal-axis exploratory factor analysis revealed an 11 factor structure that accounts for 61.92% of total explained variance of adolescent connectedness measured by the Hemingway, similar to results found in the adolescent samples in the United States. Two additional Hemingway subscales (connectedness to siblings and to boyfriend/girlfriend are also described. Correlations between domains of connectedness and additional data obtained from these adolescents, their parents, and their teachers support the construct validity of the measure in this Chilean sample. Connectedness is an important protective factor among adolescents across many national contexts and the Hemingway is a promising measure for use with Chilean adolescents.Se examinó el constructo conectividad en 390 adolescentes chilenos en un colegio urbano y católico de Santiago. Mediante un análisis factorial exploratorio de la escala Hemingway Measure of Adolescent Connectedness (Hemingway, Karcher, 2003 se observó una estructura de 11 factores que da cuenta de un 61,92% de la varianza explicada de la conectividad de los adolescentes medida por la escala Hemingway, lo cual es muy similar a los resultados obtenidos en muestras de adolescentes estadounidenses. También se describen dos subescalas adicionales (la conectividad con los/las hermanos/as y con los/las pololos/as. Las relaciones entre los factores de conectividad y los datos reportados por los adolescentes, sus padres y profesores contribuyen también a la validez de constructo de la escala en esta muestra chilena. Para los adolescentes de distintos contextos culturales la conectividad es un factor importante de protección y la escala Hemingway es un instrumento de uso prometedor

  9. Manifestaciones pulmonares del Lupus Eritematoso Sistémico Pulmonary manifestations of systemic lupus erithematosus

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    José Fernando Molina

    1991-03-01

    Full Text Available En esta revisión se describen las diversas manifestacionespulmonares del Lupus Eritematoso Sistémico; se Incluyen tanto los cuadrosrelacionados con la enfermedad (pleuritis con o sin derrame, neumonitis lúpicaaguda, enfermedad intersticlaidifusa, hipertensión pulmonar, disfunción diafragmática,atelectasia y hemorragia pulmonar como los asociados a ella (infección, edemapulmonar urémico, embolismo pulmonar, neumotórax, pseudolinfoma y sarcoidosis.Se consideran someramente aspectos clínicos, patológicos, patogénicos,diagnósticos y terapéuticos. En cuanto a los últimos se enfatizan algunasconsideraciones generales de importancia en el manejo de estos pacientes; sonellas: la necesidad de descartar ante todo la posibilidad de un proceso Infecciosoy de emplear antibióticos de amplio espectro hasta excluir1o; la de agotarrecursos hasta establecer un diagnóstico definitivo y la de recurrir a laterapia inmunosupresora una vez excluida la infección O cuando no ha habidorespuesta a los antibióticos adecuados

    The various pulmonary manifestations of Systemic Lupus Erythematosus are described in this review; it includes related (pleurisy with/without effusion, acute lupus pneumonitis, diffuse interstitial disease, pulmonary hypertension, diaphragmatic dysfunction, atelectasis, pulmonary hemorrhage as well as associated (infection, uremic pulmonary edema, pulmonary embolism, pneumothorax, pseudolymphoma, sarcoldosis, miscellaneous conditions. Clinical, pathological, pathogenic, diagnostic and therapeutic aspects are con. sidered. Emphasis is done on certain general therapeutic considerations, namely: to rule out the possibillty of an infectious process and use wide-spectrum antibiotics until certainty is acquired that it is not present; to use every available diagnostic resource until a definite diagnosis Is established

  10. Lupus panniculitis involving the breast

    Energy Technology Data Exchange (ETDEWEB)

    Sabate, Josep M.; Gomez, Antonio; Torrubia, Sofia; Salinas, Teresa; Clotet, Montse [Universitat Autonoma de Barcelona, Unity of Breast Imaging, Department of Diagnostic Radiology, Hospital de Sant Pau, Barcelona (Spain); Lerma, Enrique [Universitat Autonoma de Barcelona, Department of Pathology, Hospital de Sant Pau, Barcelona (Spain)

    2006-01-01

    Lupus panniculitis is an unusual immunological disease that characteristically affects the subcutaneous fat and occurs in 2% of patients with systemic lupus erythematosus. We report a case of lupus panniculitis involving the breast, which represents a very uncommon location. Mammographically, it presented as a suspicious irregular mass involving the subcutaneous fat pad with skin thickening. High echogenicity constituted the most relevant sonographic finding. To the best of our knowledge, the magnetic resonance (MR) features have not been previously described. High signal intensity was found on both T1- and T2-weighted precontrast MR images. A dynamic contrast-enhanced study revealed a suspicious focal mass with irregular margins and rim enhancement, with a type 3 time-signal intensity curve. Differential diagnosis with carcinoma and fat necrosis and the value of core biopsy are discussed. (orig.)

  11. Lupus panniculitis involving the breast

    International Nuclear Information System (INIS)

    Lupus panniculitis is an unusual immunological disease that characteristically affects the subcutaneous fat and occurs in 2% of patients with systemic lupus erythematosus. We report a case of lupus panniculitis involving the breast, which represents a very uncommon location. Mammographically, it presented as a suspicious irregular mass involving the subcutaneous fat pad with skin thickening. High echogenicity constituted the most relevant sonographic finding. To the best of our knowledge, the magnetic resonance (MR) features have not been previously described. High signal intensity was found on both T1- and T2-weighted precontrast MR images. A dynamic contrast-enhanced study revealed a suspicious focal mass with irregular margins and rim enhancement, with a type 3 time-signal intensity curve. Differential diagnosis with carcinoma and fat necrosis and the value of core biopsy are discussed. (orig.)

  12. Pro: Cyclophosphamide in lupus nephritis.

    Science.gov (United States)

    Kallenberg, Cees G M

    2016-07-01

    Based on efficacy and toxicity considerations, both low-dose pulse cyclophosphamide as part of the Euro-Lupus Nephritis protocol and mycophenolate mofetil (MMF) with corticosteroids may be considered for induction of remission in patients with proliferative lupus nephritis. The long-term follow-up data available for low-dose pulse cyclophosphamide, the fact that compliance is guaranteed with this regimen and economic issues all favour the Euro-Lupus regimen in this author's opinion. For maintenance treatment, either azathioprine (AZA) or MMF may be used; AZA is preferred in case pregnancy is planned, while MMF is preferred when the disease relapses during use of AZA and, possibly, after successful induction of remission with MMF. PMID:27190359

  13. Lupus nephritis in children

    International Nuclear Information System (INIS)

    To determine the clinicopathological pattern of lupus nephritis in paediatric nephrology patients. Twenty six patients upto the age 16 years of either gender, with a mean age of 12.4 +- 1.90 years having primary SLE with renal involvement in the form of oedema, hypertension, haematuria and proteinuria were included. Twenty one were females. Percutaneous renal biopsy was performed. Histological lesion was classified according to WHO classification. Patients were treated with immunosuppressive therapy and their clinical course was followed for at least one year. The mean duration of follow up was 1.77 years. Renal involvement was seen in 92.30% within 2 years of the onset of primary disease. Diffuse proliferative glomerulonephritis was the commonest histological lesion (n=14) followed by membranous nephropathy (n=6). The commonest clinical manifestation was oedema (80.76%) followed by hypertension (46.15%). Proteinuria was present in 100% of cases, haematuria in 38.46% and azotemia in 19.33% of patients. Nephrotic range proteinuria was more common in class III and IV, while azotemia was observed only in class IV. The disease was well controlled in 73.07% , relapse was seen in 3.8% of patients, 15.38% died of infections and uremic encephalopathy while 7.69% were lost to follow-up. Diffuse proliferative glomerulonephritis is the commonest histological lesion in our set-up. Renal involvement is mostly seen within first two years of the primary disease which can be controlled satisfactorily with immunosuppressive therapy. (author)

  14. Animal Models of Interferon Signature Positive Lupus.

    Science.gov (United States)

    Zhuang, Haoyang; Szeto, Christopher; Han, Shuhong; Yang, Lijun; Reeves, Westley H

    2015-01-01

    Human lupus is strongly associated with a gene expression signature characterized by over-expression of Type I interferon-regulated genes. A strong interferon signature generally is not seen in the standard mouse models of lupus, despite considerable evidence for the involvement of toll-like receptor-driven interferon production. In contrast, pristane-induced lupus exhibits a prominent TLR7-dependent interferon signature. Importantly, genetic disorders with dysregulated interferon production in both human beings and mice cause severe autoinflammatory diseases but not the typical manifestations of lupus, suggesting that interferon over-production is insufficient to cause systemic lupus erythematosus itself. Single-gene models in mice suggest that lupus-like disease may result from abnormalities in B-cell activation and the clearance of dead cells. Pristane may mimic human systemic lupus erythematosus by causing synergistic abnormalities in interferon production along with defective clearance of apoptotic cells and over-active B-cell signaling. PMID:26097482

  15. Lupus at the molecular level

    Institute of Scientific and Technical Information of China (English)

    Mayami Sengupta; Laurence Morel

    2011-01-01

    Systemic lupus erythematosus (SLE) is a debilitating multifactorial autoimmune disease (Shlomchik et al.,2001;La Cava,2009;Perry et al.,2011).It involves multiple organ systems with tissue damage driven by the activation of autoreactive Tand B cells (Bruns et al.,2000;Langer et al.,2007).It can exist for years before being diagnosed and is known to be more common in women than in men.Intense research efforts have uncovered a complex lupus pathogenesis,many aspects of which are not very clear (Perry et al.,2011).

  16. Rethinking biologics in lupus nephritis.

    Science.gov (United States)

    Venuturupalli, S

    2016-09-01

    Lupus nephritis (LN) is a chronic and devastating complication of systemic lupus erythematosus. Despite advances in our understanding of LN and the availability of effective therapies, LN remains a difficult clinical problem, and progression to end stage renal disease remains a significant challenge. Though the advent of biologics has revolutionized the treatment of many rheumatological conditions, and several clinical trials of biologics have been conducted in LN, the promise of biologics remains unfulfilled. The experience gained from these initial clinical trials can help tailor approaches in future clinical trials, and the lessons learned can be applied to find a cure for this condition. PMID:27497255

  17. Diferencias de género y edad en autoconcepto en estudiantes adolescentes chilenos

    OpenAIRE

    Vicent Juan, Maria; Lagos San Martín, Nelly; Gonzálvez Macià, Carolina; Cándido J. Inglés; García Fernández, José Manuel; Gomis Selva, Nieves

    2015-01-01

    Investigaciones previas han puesto de manifiesto la importancia del estudio del autoconcepto durante la adolescencia. El objetivo de este estudio consistió en analizar las diferencias de género y edad en las distintas dimensiones del autoconcepto en una muestra de 1414 estudiantes chilenos de entre 13 y 18 años. El autoconcepto fue evaluado mediante la versión breve del SDQII. Los resultados evidenciaron diferencias de género para las dimensiones Autoconcepto Verbal, Apariencia Física, Sincer...

  18. El Movimiento estudiantil chileno y el proceso de reforma universitaria, 1967-1968

    OpenAIRE

    Cancino, Hugo

    2012-01-01

    En la presente ponencia analizamos el contexto histórico y cultural del movimiento de reforma de la Universidad de Chile, 1967-68 y su gestación en la Facultad de Filosofía y Educación. Este movimiento que se inscribió en la dilatada tradición de lucha de los estudiantes chilenos y latinoamericanos fue parte significativa de los movimientos juveniles y populares que irrumpieron en el escenario histórico en los años sesenta. Nos ocupamos de sus formas de lucha directa desde la base estudiantil...

  19. La cultura nacional y su impacto en los negocios: el caso chileno

    OpenAIRE

    Pedro Hidalgo Campos; Enrique Manzur Mobarec; Sergio Olavarrieta Soto; Pablo Farías Nazel

    2007-01-01

    El objetivo de este artículo es analizar el impacto de la cultura nacional en los negocios. Uno de los investigadores más destacados en el análisis de la cultura nacional es Geert Hofstede (1980). Él identificó cuatro dimensiones de la cultura nacional: distancia de poder, aversión a la incertidumbre, individualismo y masculinidad. Fernández et al. (1997) midieron estas cuatro dimensiones en Chile, caracterizando a los chilenos en esas cuatro dimensiones. R...

  20. Factores de riesgo cardiovascular en estudiantes universitarios chilenos

    Directory of Open Access Journals (Sweden)

    Chiang-Salgado María Teresa

    1999-01-01

    Full Text Available OBJETIVO: Evaluar la prevalencia de factores de riesgo cardiovascular en universitarios asintomáticos de ambos sexos, de entre 18 y 25 años de edad. MATERIAL Y MÉTODOS: La muestra quedó integrada por 1 301 estudiantes. En una submuestra de 293 sujetos se midieron lípidos séricos, con un analizador químico Hitachi 717. La obesidad se estimó considerando el índice de masa corporal (IMC; el antecedente familiar de infarto, así como el consumo de cigarrillos y el nivel de actividad física se determinaron mediante un cuestionario de autoevaluación. Se construyeron tablas de contingencia para estudiar asociaciones entre factores de riesgo lipídicos y no lipídicos, usando la prueba ji² de Pearson. Se realizó un análisis de regresión múltiple para determinar la relación de cada una de las variables lipídicas (colesterol total, colesterol-lipoproteína de baja densidad, colesterol-lipoproteína de alta densidad y triglicéridos, así como de las no lipídicas (edad, peso, estatura, IMC, sexo, presión arterial, conducta sedentaria y antecedente familiar de infarto precoz. RESULTADOS: Se encontraron niveles de riesgo lipídico en 29.2% de los casos para colesterol total, en 16.2% para lipoproteína de baja densidad y en 5% para lipoproteína de alta densidad. Entre los factores de riesgo no lipídicos más prevalentes, estaban el consumo de cigarrillos, con 46.1%, y el sedentarismo, que alcanzó 60.8%. La obesidad, la hipertensión arterial y el antecedente familiar alcanzaron 1.9, 4.6 y 11%, respectivamente. Se observó una asociación entre el perfil lipídico de riesgo, la obesidad, la conducta fumadora y el antecedente familiar. CONCLUSIONES: Los resultados mostraron una alta prevalencia de sedentarismo y conducta fumadora, asociada a un perfil lipídico de riesgo. Se deduce la necesidad imperiosa de diseñar programas de intervención con el fin de modificar el estilo de vida y prevenir la posible presencia de enfermedades

  1. ¿Educadores o consumidores? discrepancia del yo, consumo y materialismo en estudiantes chilenos de pedagogía

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    Marianela Denegri Coria

    2014-05-01

    Full Text Available El presente artículo tiene como propósito caracterizar las relaciones existentes entre la discrepancia del Yo, las actitudes hacia la compra y valores materialistas en estudiantes de Pedagogía considerando diferencias de género. Se aplicaron las escalas de Discrepancia del Yo, Actitudes hacia la Compra y Valores Materiales, en una muestra de 167 estudiantes chilenos de las carreras de Pedagogía en Historia de dos universidades del Sur de Chile. Los resultados obtenidos, evidencian correlaciones significativas entre las dimensiones de discrepancia del Yo físico, intelectual y económico, y las actitudes impulsivas y compulsivas hacia la compra; así como en las dimensiones de valores materiales vinculadas al éxito social y felicidad personal. En cuanto al género, se observa en las mujeres un perfil de ambivalencia actitudinal, donde coexiste la racionalidad con la compulsividad. A partir de la relevancia social del futuro ejercicio profesional de los estudiantes de pedagogía, los resultados se discuten considerando la importancia de la inclusión de la educación económica y financiera en la formación inicial de profesores, con un fuerte énfasis en la toma de conciencia acerca de sus actitudes y valores hacia el consumo. This paper aims to characterize the relationship between Self-discrepancy, attitudes toward buying and materialistic values ​​in pedagogy students considering gender differences. The Self-discrepancy scale and the Attitudes toward Purchase and Material Values scale were applied in a sample of 167 Chilean Pedagogy students majoring in History teaching in two universities in southern Chile. The results show significant correlations for Self-discrepancy between the physical, intellectual and economic dimensions and the impulsive and compulsive attitudes towards buying, as well as the dimensions of materialism linked to social success and personal happiness. Regarding gender, women display an ambivalent attitudinal

  2. Análisis preliminar del gobierno universitario chileno

    Directory of Open Access Journals (Sweden)

    Francisco A. Ganga-Contreras

    2005-01-01

    Full Text Available Es axiomático que los megacambios que se suceden hoy en día en el mundo, han influido en la forma como las organizaciones deben ser gestionadas. Esta situación ha afectado a las universidades, desprendiéndose que existen espacios relevantes para repensarlas en todas sus dimensiones, y la gestión es quizás una de las más vitales, dado que se constituye en el eje vertebrador de los objetivos de cualquier institución. El presente trabajo pretende proporcionar información de reconocimiento del problema del gobierno universitario, considerando a tres universidades regionales y amparado con fundamento en la teoría sobre el gobierno corporativo y el enfoque de agencia. Se busca identificar la percepción de las autoridades, respecto a la eficiencia del gobierno en las universidades chilenas y del entorno de la cual son parte; y además, analizar la relación de agencia que se da entre los rectores y su máximo cuerpo colegiado. Los resultados revelan: asimetrías de información, divergencias en cuanto a intereses y mecanismos alineadores entre los rectores y su máximo cuerpo colegiado y coincidencia sobre la eficiencia y las bondades del control. Se concluye sobre la necesidad de ampliar este tipo de investigación con miras al mejoramiento de las relaciones entre los rectores y el máximo cuerpo colegiado.

  3. Systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    Manson Jessica J

    2006-03-01

    Full Text Available Abstract Systemic lupus erythematosus (SLE is a clinically heterogeneous disease, which is autoimmune in origin and is characterized by the presence of autoantibodies directed against nuclear antigens. It is a multi-system disease, and patients can present in vastly different ways. Prevalence varies with ethnicity, but is estimated to be about 1 per 1000 overall with a female to male ratio of 10:1. The clinical heterogeneity of this disease mirrors its complex aetiopathogenesis, which highlights the importance of genetic factors and individual susceptibility to environmental factors. SLE can affect every organ in the body. The most common manifestations include rash, arthritis and fatigue. At the more severe end of the spectrum, SLE can cause nephritis, neurological problems, anaemia and thrombocytopaenia. Over 90% of patients with SLE have positive anti-nuclear antibodies (ANA. Significant titres are accepted to be of 1:80 or greater. SLE is a relapsing and remitting disease, and treatment aims are threefold: managing acute periods of potentially life-threatening ill health, minimizing the risk of flares during periods of relative stability, and controlling the less life-threatening, but often incapacitating day to day symptoms. Hydroxychloroquine and non-steroidal anti-inflammatory drugs are used for milder disease; corticosteroids and immunosuppressive therapies are generally reserved for major organ involvement; anti-CD20 monoclonal antibody is now used in patients with severe disease who has not responded to conventional treatments. Despite enormous improvements in prognosis since the introduction of corticosteroids and immunosuppressive drugs, SLE continues to have a significant impact on the mortality and morbidity of those affected.

  4. La nación en el discurso de la derecha. Un análisis ideológico del debate parlamentario chileno

    OpenAIRE

    Antonieta Muñoz-Navarro

    2008-01-01

    Este trabajo se enmarca en la comunicación política y estudia el discurso parlamentario chileno, específicamente el discurso senatorial conservador. La tesis planteada es que la concepción de nación tradicional, formulada como ideología, impide perfeccionar la democracia chilena y, específicamente, se usa contra las aspiraciones de representatividad del principal pueblo indígena chileno: los Mapuche. A partir del análisis del discurso ideológico, se observan los debates parlamentarios chileno...

  5. Virus de la Enfermedad Infecciosa de la Bolsa de Fabricio: Relaciones antigénicas de aislados cubanos y chilenos Infectious Bursal Disease Virus: antigenic interrelationships between

    Directory of Open Access Journals (Sweden)

    J Noda

    2005-01-01

    Full Text Available La Enfermedad Infecciosa de la Bolsa (EIB sigue afectando la industria avícola por la aparición de variantes patogénicas y antigénicas del virus, originadas en la permanente evolución del virus producto de la presión inmunológica por el uso intensivo de vacunas. La caracterización antigénica de los virus de campo resulta esencial para la aplicación de vacunas más adecuadas en el control de la enfermedad. En este trabajo se determinaron las relaciones antigénicas de aislados cubanos y chilenos, obtenidos de poblaciones de pollos vacunados con el virus de la EIB. Los aislados virales se adaptaron a cultivos celulares y se obtuvieron antisueros monoespecíficos de cada uno de ellos y de una cepa de referencia. Las relaciones se establecieron por virusneu-tralización cruzada utilizando nueve aislados cubanos (BD, BL, 35/95, 29/96, 118/96, BF2, BF8, BF9 y 70/98, tres chilenos (G1, G2 y G4 y una cepa de referencia del serotipo 1 (Lukert. Los aislados cubanos y chilenos se adaptaron eficientemente a cultivos de fibroblastos de embrión de pollo (con excepción de BF3 y G3. Además, los aislados cubanos se adaptaron a células VERO, presentando mayores títulos infectivos en fibroblastos de embrión de pollo que en esta línea celular. Los resultados de la seroneutralización cruzada mostraron entre los aislados cubanos una relación mayor a un 80% y entre éstos y la cepa de referencia mayor de un 70%, de igual modo con los aislados chilenos G1 y G4 (mayor de 77%. El aislado G2 presentó diferencias antigénicas consideradas menores con los aislados cubanos BL, 35/95 y 29/96 (­ 69%. Ninguno de los aislados mostró relaciones antigénicas inferiores al 30% con la cepa de referencia del serotipo 1, por lo tanto no corresponden a cepas variantesInfectious Bursal Disease (IBD is still affecting the poultry industry through the appearance of pathogenic and antigenic variations of the virus. This is due to its permanent evolution as a

  6. Devic syndrome associated to systemic lupus erythematosus. Case report.

    OpenAIRE

    Juan Camilo Botero; Alejandro García; Juliana Hidalgo

    2009-01-01

    El síndrome de Devic es una las enfermedades desmielinizantes del sistema nervioso central, de etiología desconocida. Se relaciona mucho con el lupus eritematoso sistémico siendo una complicación rara y grave. Este síndrome se presenta como mielitis transversa de compromiso a nivel cervical y neuritis óptica. Se describe el caso de de una paciente de 32 años, que se presentó al servicio de urgencias por dolor en región torácica, pérdida de la fuerza muscular progresiva en los miembros inferio...

  7. Alelos HLA DRB1 no Lupus Eritematoso Incompleto

    OpenAIRE

    Maure Noia, Brenda

    2014-01-01

    O lupus eritematoso sistémico é unha enfermidade multifactorial na que se sabe que participan mecanismos xenéticos. A asociación máis consistente encontrouse nos xenes do complexo maior de histocompatibilidade de clase II, en concreto nos alelos DRB1*03 e DRB1*15. Entre os pacientes atendidos en consultas de enfermidades autoinmunes hai algúns con anticorpos anti-nucleares (ANA) positivos e manifestacións clínicas suxestivas de LES, pero que non reúnen 4 criterios de clasificación, polo que s...

  8. Personality disorders and emotional variables in patients with lupus

    OpenAIRE

    Co??n-Mej??as, Mar??a ??ngeles; Peralta-Ram??rez, Mar??a Isabel; Callejas-Rubio, Jos?? Luis; P??rez Garc??a, Miguel

    2007-01-01

    El lupus eritematoso sist??mico (LES) es una enfermedad de car??cter autoinmune que afecta principalmente a mujeres en edad f??rtil. Los s??ntomas m??s comunes de los pacientes incluyen dolor articular, erupciones cut??neas, cansancio o fatiga y dificultad en la respiraci??n. Aunque el curso de la enfermedad es cr??nico, evoluciona normalmente en forma de brotes, que se alternan con periodos de remisi??n relativa. Si bien la etiolog??a es desconocida, se sabe que existe u...

  9. Ultraviolet light and cutaneous lupus

    NARCIS (Netherlands)

    Bijl, Marc; Kallenberg, Cees G. M.

    2006-01-01

    Exposure to ultraviolet (UV) light is one of the major factors known to trigger cutaneous disease activity in (systemic) lupus erythematosus patients. UV light, UVB in particular, is a potent inducer of apoptosis. Currently, disturbed clearance of apoptotic cells is one of the concepts explaining th

  10. Lymphoma risk in systemic lupus

    DEFF Research Database (Denmark)

    Bernatsky, Sasha; Ramsey-Goldman, Rosalind; Joseph, Lawrence;

    2014-01-01

    OBJECTIVE: To examine disease activity versus treatment as lymphoma risk factors in systemic lupus erythematosus (SLE). METHODS: We performed case-cohort analyses within a multisite SLE cohort. Cancers were ascertained by regional registry linkages. Adjusted HRs for lymphoma were generated in...

  11. Kinin system in lupus nephritis.

    Science.gov (United States)

    Dellalibera-Joviliano, R; Reis, M L; Donadi, E A

    2001-09-01

    There are few studies regarding the evaluation of the kinin system in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the plasma levels of high-molecular weight kininogen (HKg), low-molecular weight kininogen (LKg) and plasma kallikrein; the plasma activity of tissue kallikrein and kininase II, and urinary kallikrein and kininase II activities in patients presenting with active lupus nephritis. A total of 30 patients (29 women) aged 21-62 years (median = 39) and 30 controls matched to the patients for sex and age were studied. Patients presenting with other underlying diseases or using drugs, which could interfere with the kinin system, were excluded. HKg and LKg levels were indirectly evaluated by ELISA. Plasma kallikrein, tissue kallikrein, and kininase II were evaluated by their enzymatic activity on selective substrates. The Mann-Whitney test was used for statistical analysis. HKg, LKg and plasma kallikrein levels were significantly increased in patients (p < 0.001, for each comparison). Similarly, tissue kallikrein and kininase II activities were significantly increased in plasma and urine of patients (p <0.001, for each comparison). In urine, the activities of tissue kallikrein and kininase II were at least seven times higher than those seen in the plasma of patients. These results indicate that the kinin system is involved in the acute manifestations of lupus nephritis. Kinins may facilitate immunecomplex deposition and may induce the release of other pro-inflammatory mediators, including cytokines actively involved in the pathogenesis of lupus nephritis. PMID:11562080

  12. Teatro chileno y anarquismo (desde comienzos de siglo XX hasta el período dictatorial Chilean Theatre and Anarchism (from the beginning of 20th century to the dictatorship

    Directory of Open Access Journals (Sweden)

    Sara Rojo

    2008-12-01

    Full Text Available Este estudio analiza la relación entre el pensamiento anarquista y el teatro en Chile desde comienzos de siglo hasta el período de la dictadura militar. Comienza con un recorte teórico del concepto de anarquismo dentro del marco histórico chileno, para posteriormente analizar, de manera cronológica, producciones teatrales específicas del período anteriormente citado.This study analyzes the relationship between anarchist thinking and theatre in Chile from the beginning of the century up to the time of the military dictatorship. It begins with a theoretical highlight of the concept of anarchism in Chilean history and later chronologically analyzes theater plays that are specific to the abovementioned period.

  13. Prevalencia de gingivitis y factores asociados en niños chilenos de cuatro años Prevalence of gingivitis and associated factors in 4 year-old Chilean children

    OpenAIRE

    C Zaror Sánchez; P. Muñoz Millán; A. Sanhueza Campos

    2012-01-01

    Objetivos: Determinar la prevalencia y distribución de gingivitis y su relación con factores socioeconómicos, biológicos y locales en niños chilenos de 4 años. Metodología: Se realizó un estudio transversal enpreescolares de 4 años que acuden al Hospital de Calbuco, Región de Los Lagos, Chile. La muestra consistió en 102 niños/niñas de 4 años. Un examinador, previamente calibrado, realizó examen odontológico, determinando presencia de placa bacteriana visible, caries dental y sangramiento gin...

  14. LA EXTERNALIZACIÓN LABORAL Y LA CESIÓN ILEGAL DE TRABAJADORES EN EL SISTEMA JURÍDICO CHILENO Labor outsourcing and illegal cession of workers at the chilean law system

    Directory of Open Access Journals (Sweden)

    Irene Rojas Miño

    2010-01-01

    Full Text Available Este trabajo identifica a la cesión ilegal de trabajadores como manifestación ilícita de la externalización laboral. A la vez, analiza la configuración de la cesión ilegal de trabajadores en el ordenamiento jurídico chileno, sus concretos efectos jurídicos y, además, un particular problema que se ha planteado con la eficacia de la norma jurídica que establece este ilícito laboral.This work identifies the illegal cession of workers, as the illicit manifestation of the labor outsourcing. At the same time, it analyzes the illegal cession of workers configuration at the Chilean law system, its specifics legal effects and a particular problem derived of the efficiency of the law that establishes this labor illicit.

  15. El impacto social y cultural de la publicidad entre los jóvenes chilenos The Social and Cultural Impact of Advertising among Chilean Youths

    Directory of Open Access Journals (Sweden)

    Maite Rodríguez Salineros

    2010-10-01

    Full Text Available El presente trabajo analiza el impacto de la publicidad entre jóvenes chilenos de distintos estratos socioeconómicos, con el objetivo de identificar la relación que establecen con la publicidad y la particular incorporación que hacen de ésta en sus estrategias de socialización. Por lo tanto, no se pretende dar cuenta de lo que la publicidad hace con los jóvenes, sino de lo que los jóvenes hacen con la publicidad a través de sus prácticas de recepción y apropiación. Para esto, se realizó un estudio sobre la base de grupos de discusión a jóvenes de ambos sexos, de edades entre 15 y 24 años provenientes de los niveles socioeconómicos altos y bajos residentes en Santiago de Chile. Los resultados que arrojó el estudio dan cuenta de que la publicidad es asumida como parte constitutiva de la oferta medial, la que es utilizada como información comercial y referente cultural de nuevos valores estéticos. Junto con esto, la publicidad adquiere el carácter de agente de socialización, al incorporar los contenidos de los mensajes publicitarios en las conversaciones con sus pares. Finalmente, este trabajo concluye que la publicidad entre los jóvenes chilenos estudiados, se presenta como una realidad sociocultural de primer orden, en cuanto actor central de su vida cotidiana.This work analyzes the impact of advertising among Chilean youngsters of different socioeconomic background. We aim to identify the relationship that this group establishes with advertising and, in particular, the way they incorporate it in their socialization strategies. We do not address what advertising does to youngsters, but instead what youngsters do with advertising in their practices of appropriation and reception of it. The research design included focus groups of male and female youngsters living in Santiago de Chile between 15 and 24 years of age coming from both high and low-income background. The conclusion of our research is that advertising is assumed

  16. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Petri, Michelle; Orbai, Ana-Maria; Alarcón, Graciela S;

    2012-01-01

    The Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria in order to improve clinical relevance, meet stringent methodology requirements, and incorporate new kno...

  17. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Petri, Michelle; Orbai, Ana-Maria; Alarcón, Graciela S;

    2012-01-01

    The Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria in order to improve clinical relevance, meet stringent methodology requirements, and incorporate new...

  18. Successful treatment of severe refractory lupus hepatitis with mycophenolate mofetil.

    Science.gov (United States)

    Tagawa, Y; Saito, T; Takada, K; Kawahata, K; Kohsaka, H

    2016-04-01

    Systemic lupus erythematosus-related hepatitis, known as lupus hepatitis, is a rare manifestation of systemic lupus erythematosus, and is usually subclinical with mild abnormalities of serum liver enzymes. While cases with clinically significant and refractory lupus hepatitis are uncommon, treatment options for lupus hepatitis are to be established. Here, we report the case of a 45-year-old man with progressive lupus hepatitis accompanied by autoimmune haemolytic anaemia. Lupus hepatitis of this patient was refractory to tacrolimus, azathioprine and cyclophosphamide, but was successfully treated by mycophenolate mofetil. Mycophenolate mofetil might be an effective therapeutic option for refractory lupus hepatitis. PMID:26762472

  19. 77 FR 38305 - Guidance for Industry on Lupus Nephritis Caused by Systemic Lupus Erythematosus-Developing...

    Science.gov (United States)

    2012-06-27

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry on Lupus Nephritis Caused by Systemic... a notice published in the Federal Register of June 22, 2010 (75 FR 35492), FDA announced the availability of a guidance entitled ``Lupus Nephritis Caused By Systemic Lupus...

  20. Más allá del “modelo” chileno: una aproximación multi-sectorial a las relaciones Estado-mercado

    Directory of Open Access Journals (Sweden)

    Antoine Maillet

    2015-09-01

    Full Text Available ResumenChile ha sido muchas veces caracterizado como un “modelo” desde los años 1990. Sin embargo, esta clasificación opaca la diversidad existente en las relaciones Estado-mercado. En cambio, una aproximación mediante la comparación multisectorial permite dar cuenta de la heterogeneidad de las políticas públicas en relación a los mercados, y no confundirlas bajo un supuesto “modelo” uniforme. La demonstración se fundamenta en el análisis de las trayectorias sectoriales en materias de energía eléctrica, transporte público en Santiago y pensiones desde las reformas de los Chicago Boys durante la dictadura de Pinochet hasta hoy. Basado en análisis de prensa, entrevistas con actores claves, y una extensiva revisión de bibliografía especializada, se evidencia cómo las políticas, a partir de un mismo punto de origen al final de la dictadura, tomaron caminos distintos durante los gobiernos democráticos. El caso chileno aparece entonces más fragmentado que lo generalmente considerado. Más allá del caso, esta diversidad señala la necesidad de una mayor atención a los procesos de diferenciación y autonomización de las políticas públicas sectoriales.

  1. COLONIALISMO CHILENO, CENSURA FRONTERIZA Y ORTOGRAMAS* REACCIONARIOS: RESPUESTA A SERGIO VILLALOBOS RIVERA CHILEAN COLONIALISM, BORDER CENSORSHIP AND REACTIONARY ORTOGRAMS: REPLY TO SERGIO VILLALOBOS RIVERA

    Directory of Open Access Journals (Sweden)

    Jorge Pavez Ojeda

    2012-06-01

    Full Text Available Se responde a la reseña de Sergio Villalobos de la obra Cartas Mapuche. SigloXIX(2008, intentando explicar las lógicas que subyacen al silencio de Villalobos sobre las cartas mismas y sus ataques ab hominem al compilador de las cartas. Se relacionan los argumentos de la reseña comentada con la ideología reaccionaria de cierta historiografía chilena y su particular concepto de "estudios fronterizos", mostrando como esta ideología defiende y reproduce las censuras históricas del colonialismo y el racismo chilenos.In this paper, I answer Sergio Villalobos' review of the book Cartas Mapuche. Siglo XIX (2008, looking for explaining the rationale that underlies the silence ofVillalobos about the letters themselves and his attack ab hominem to the compiler of the letters. I relate the arguments of the commented review to the reactionary ideology of certain Chilean historiography and its particular concept of "Frontier Studies", showing how this ideology defend and reproduce the historical censorship of the Chilean colonialism and racism.

  2. Clinical characteristics of cutaneous lupus erythematosus

    OpenAIRE

    Szczęch, Justyna; Rutka, Maja; Samotij, Dominik; Zalewska, Agnieszka; Reich, Adam

    2016-01-01

    Introduction Lupus erythematosus (LE) shows a wide variety of clinical manifestations, skin involvement being one of the most important. Aim To analyze the clinical presentation of cutaneous variants of lupus erythematosus in terms of skin lesion spectrum and extracutaneous involvement. Material and methods A total of 64 patients with cutaneous LE (CLE) were included. The study was based on the “Core Set Questionnaire” developed by the European Society of Cutaneous Lupus Erythematosus (EUSCLE...

  3. Systemic Lupus Erythematosus and Antiphospholipid Syndrome

    OpenAIRE

    Aleksandra Plavsic; Rada Miskovic; Sanvila Raskovic; Mirjana Bogic; Branka Bonaci Nikolic

    2014-01-01

    Antiphospholipid syndrome is an autoimmune disorder defined as association of vascular thrombosis and/or pregnancy complications with presence of antiphospholipid antibodies (lupus anticoagulant, anticardiolipin and anti-β2 glycoprotein I). It is the most common cause of acquired thrombophilia, and can occur as an independent entity or in relation with other diseases, especially systemic lupus erythematosus. Presence of antiphospholipid syndrome in systemic lupus erythematosus is additional v...

  4. Th Subset Balance in Lupus Nephritis

    OpenAIRE

    Katsuhisa Miyake; Mitsuteru Akahoshi; Hitoshi Nakashima

    2011-01-01

    Lupus nephritis, which has various histological patterns and variable clinical outcomes, is one of the most important complications of systemic lupus nephritis (SLE). This pathogenetic mechanism in each histologically different type of lupus nephritis (LN) remains unclear. Although SLE is suggested to be a Th2-driven disease, elevation of both Th1 and Th2 cytokines occurs in both humans and mice, suggesting that SLE is a complex disease driven by different lymphocyte subsets with high heterog...

  5. The Role of Autophagy in Lupus Nephritis

    OpenAIRE

    Linlin Wang; Helen Ka Wai Law

    2015-01-01

    Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease characterized by the generation of immune responses to self-antigens. Lupus nephritis is one of the most common and severe complications in SLE patients. Though the pathogenesis of lupus nephritis has been studied extensively, unresolved questions are still left and new therapeutic methods are needed for disease control. Autophagy is a conserved catabolic process through which cytoplasmic constituents can be degraded in...

  6. Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis

    OpenAIRE

    Alba, P.; L. Bento; Cuadrado, M; Karim, Y; Tungekar, M; Abbs, I; Khamashta, M; D'Cruz, D; Hughes, G.

    2003-01-01

    Background: Lupus nephritis (LN) is a common manifestation in patients with systemic lupus erythematosus (SLE). Autoantibodies and ethnicity have been associated with LN, but the results are controversial.

  7. Hallazgos ecográficos e histológicos del hígado de 414 pacientes con obesidad mórbida Liver ultrasound and pathology in 414 morbid obese patients

    OpenAIRE

    ATTILA CSENDES; GLADYS SMOK; ANA MARIA BURGOS; PAULA CSENDES

    2006-01-01

    Introducción: Las alteraciones de la histología hepática constituyen un hallazgo frecuente en pacientes con obesidad mórbida y pueden correlacionarse con los niveles sanguíneos de lípidos. Objetivos: Determinar la prevalencia de anormalidades histológicas del hígado en un gran número de pacientes chilenos con obesidad mórbida, correlacionados con los niveles de lípidos sanguíneos y con los hallazgos ecográficos preoperatorios. Material y Método: Estudio prospectivo y descriptivo de 414 pacien...

  8. Systemic Lupus Erythematosus and Antiphospholipid Syndrome

    Directory of Open Access Journals (Sweden)

    Aleksandra Plavsic

    2014-09-01

    Full Text Available Antiphospholipid syndrome is an autoimmune disorder defined as association of vascular thrombosis and/or pregnancy complications with presence of antiphospholipid antibodies (lupus anticoagulant, anticardiolipin and anti-β2 glycoprotein I. It is the most common cause of acquired thrombophilia, and can occur as an independent entity or in relation with other diseases, especially systemic lupus erythematosus. Presence of antiphospholipid syndrome in systemic lupus erythematosus is additional vaso occlusive factor in already present inflammation, bringing further risk for thrombotic events. Clinical and serological manifestations of antiphospholipid syndrome and systemic lupus erythematosus are very similar, so possible connection for these two autoimmune disorders is assumed.

  9. LUPUS PANNICULITIS AS AN INITIAL MANIFESTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS

    OpenAIRE

    Patel Raksha; Marfatia Y

    2010-01-01

    In May, 2003, a 28-year-old female presented with large non-healing ulcers on face, trunk and limbs covered with black hemorrhagic crust. There were no other systemic manifestations. Diagnosis of lupus panniculitis was considered on clinical and histopathological grounds. The lesions healed completely, with scarring, with systemic corticosteroid, hydroxychloroquine and topical 2% mupirocin. She came again in November, 2005, with malar rash, joint pain, scarring alopecia of the scalp an...

  10. Frecuencia de comportamientos anormales estereotipados en caballos Chilenos estabulados Frequency of stereotyped abnormal behaviour in stabled Chilean horses

    Directory of Open Access Journals (Sweden)

    L Muñoz

    2009-01-01

    Full Text Available La frecuencia de comportamientos anormales estereotipados como aerofagia, bamboleo y paseo circular en la pesebrera, fue estudiada en 100 caballos Chilenos, de ambos sexos, estabulados en pesebreras individuales durante todo el día o parte de éste, amansados y de dos años o más pertenecientes a 16 criaderos de la comuna de Chillán. Los caballos fueron observados desde las 7:00 a las 19:00 horas durante un día y su propietario o cuidador consultado si presentaba algún comportamiento anormal estereotipado. Los equinos de acuerdo a su edad se dividieron en dos grupos: de 2 a 5 años y mayores a 5 años, y de acuerdo al sexo en tres grupos: machos enteros, machos castrados y hembras. Los datos fueron analizados por medio de la planilla electrónica Microsoft® Excel, para establecer las frecuencias, y para comparar diferencias existentes entre los comportamientos anormales y las variables sexo y edad se utilizó la Prueba Exacta de Fisher, con un nivel de significancia de P The frequency of stereotyped abnormal behaviour i.e. windsucking/crib-biting, weaving and stall-walking were studied in 100 Chilean horses of both sex, stabled in individual boxes either all day long or during a certain period of time. All horses were tamed and older than 2 years old, and belonging to 16 studs of the Comuna de Chillán (Chile. The horses were observed between 7:00 and 19:00 hours during one day, and its owner or carer was asked whether the horse presented some stereotyped abnormal behaviour or not. Horses were separated according to age into 2 groups: 2 to 5 years old and older than 5 years, and also according to sex: stallions, geldings or mares. Data was analysed using the Microsoft® Excel Worksheet to establish frequencies. Differences between groups were analysed by Exact Fisher’s Test. Significance level was P < 0.05. The results showed that 50% of the studs had one or more horses with some stereotyped abnormal behaviour. Ten porcent of the horses

  11. LAS RELACIONES ENTRE CHILE Y CANADÁ DURANTE LA SEGUNDA GUERRA MUNDIAL: LAS PRIMERAS EXPERIENCIAS DE LOS DIPLOMÁTICOS CHILENOS

    Directory of Open Access Journals (Sweden)

    JOSÉ DEL POZO

    2005-06-01

    Full Text Available Basado en los informes diplomáticos chilenos, este artículo analiza el tema de las relaciones entre Chile y Canadá, en el período en que esos países avanzaron hacia el intercambio de embajadas, entre 1941 y 1944. En él se explica que hasta antes de esos años, Canadá solo tenía un interés comercial en América Latina, mientras que para Chile era más importante el plano diplomático, a causa de su interés en reforzar su posición internacional, un tanto debilitada desde comienzos del siglo XX. Las razones que llevaron a ambos países a tomar esa decisión estuvieron directamente relacionadas con el contexto de la Segunda Guerra Mundial. Una vez instaladas las embajadas, se comentan las impresiones que tuvieron los primeros representantes de Chile en Ottawa acerca de lo que era Canadá, lo que muestra las dificultades en comprender el funcionamiento de un país bastante distinto a Chile. El artículo concluye que el establecimiento de embajadas no trajo un incremento significativo a corto plazo en las relaciones entre ambos países, ni a nivel comercial ni políticoBased on the reports of the Chilean foreign mission in Canada, this article deals with the relations between Chile and Canada during the period in which both countries decided to exchange embassies. It explains that before those years, Canada was interested in Latin America mainly in commercial topics, while Chile showed more interest on the diplomatic side. This difference is due to the fact that Chile found itself in a rather vulnerable position before 1939. The Second World War was the main reason that led to the establishment of embassies in both countries. The article analyzes also the first impressions of the Chilean representatives in Ottawa, showing that it was not easy for Chilieans to understand the nature of a country like Canada. It ends saying that in the short term, the establishment of embassies did not lead to an increase in the commercial or the political

  12. IL-17 promotes murine lupus.

    Science.gov (United States)

    Amarilyo, Gil; Lourenço, Elaine V; Shi, Fu-Dong; La Cava, Antonio

    2014-07-15

    The proinflammatory activity of IL-17-producing Th17 cells has been associated with the pathogenesis of several autoimmune diseases. In this article, we provide direct evidence for a role of IL-17 in the pathogenesis of systemic lupus erythematosus (SLE). The induction of SLE by pristane in IL-17-sufficient wild-type mice did not occur in IL-17-deficient mice, which were protected from development of lupus autoantibodies and glomerulonephritis. The protection from SLE in IL-17-deficient mice was associated with a reduced frequency of CD3(+)CD4(-)CD8(-) double-negative T cells and an expansion of CD4(+) regulatory T cells, and did not depend on Stat-1 signaling. These data affirm the key role of IL-17 in the pathogenesis of SLE and strengthen the support for IL-17 blockade in the therapy of SLE. PMID:24920843

  13. Fatigue in systemic lupus erythematosus.

    Science.gov (United States)

    Ahn, Grace E; Ramsey-Goldman, Rosalind

    2012-04-01

    Systemic lupus erythematosus is a chronic inflammatory autoimmune disease often characterized by fatigue, with significant effects on physical functioning and wellbeing. The definition, prevalence and factors associated with fatigue, including physical activity, obesity, sleep, depression, anxiety, mood, cognitive dysfunction, vitamin D deficiency/insufficiency, pain, effects of medications and comorbidities, as well as potential therapeutic options of fatigue in the systemic lupus erythematosus population are reviewed. Due to variability in the reliability and validity of various fatigue measures used in clinical studies, clinical trial data have been challenging to interpret. Further investigation into the relationships between these risk factors and fatigue, and improved measures of fatigue, may lead to an improvement in the management of this chronic inflammatory disease. PMID:22737181

  14. Devic syndrome associated to systemic lupus erythematosus. Case report.

    Directory of Open Access Journals (Sweden)

    Juan Camilo Botero

    2009-11-01

    Full Text Available El síndrome de Devic es una las enfermedades desmielinizantes del sistema nervioso central, de etiología desconocida. Se relaciona mucho con el lupus eritematoso sistémico siendo una complicación rara y grave. Este síndrome se presenta como mielitis transversa de compromiso a nivel cervical y neuritis óptica. Se describe el caso de de una paciente de 32 años, que se presentó al servicio de urgencias por dolor en región torácica, pérdida de la fuerza muscular progresiva en los miembros inferiores, pérdida del control del esfínter urinario y disminución de la agudeza visual. También relató antecedentes de lupus eritematoso sistémico. Al examen físico se encontró atrofia y palidez del disco óptico derecho, disminución en la fuerza muscular 3/5 en miembros superiores e inferiores, alteración en la sensibilidad y propiocepción de extremidades inferiores. La resonancia magnética mostró hallazgos sugestivos de mielitis transversa de C2 a C6. En el laboratorio se encontraron anticuerpos anticardiolipina elevados y anticuerpos antinucleares: 1:320. Se manejó con esteroides, hubo notable mejoría en los síntomas y se le dio de alta al sexto día, con tratamiento ambulatorio. Los hallazgos al examen físico, laboratorio e imagenología permitieron hacer el diagnóstico de síndrome de Devic. Con base en la revisión bibliográfica, se concluye que este síndrome es poco frecuente; sin embargo, se debe tener en cuenta como posible diagnóstico en todo paciente con antecedentes de lupus eritematoso sistémico y síntomas compatibles.

  15. Pregnancy in systemic lupus erythematosus

    OpenAIRE

    Mok, C.; Wong, R

    2001-01-01

    Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women of reproductive age. Pregnancy and its outcome is a major concern to most SLE patients. Queries regarding the risk of disease flares during pregnancy, chance of fetal loss, and the safety of various drugs are often raised. With the improvement in the understanding of the pathogenesis of SLE and the judicious use of immunosuppressive drugs, better disease control can now be achieved and SLE patients sh...

  16. Updates on Lupus and Pregnancy

    OpenAIRE

    Buyon, Jill P.

    2009-01-01

    This review focuses on events subsequent to planning a pregnancy and addresses three components of concern for women with systemic lupus erythematosus: maternal, placental, and fetal. Flare rates are generally low for patients who are clinically stable at conception. For patients who have never had renal disease, there is no firm evidence that they will develop active renal disease simply due to being pregnant. For patients who begin pregnancy with an abnormal creatinine (> 2 mg/dl is ill adv...

  17. Fundamentos para un estudio del guion en el cine chileno: notas preliminares

    Directory of Open Access Journals (Sweden)

    Rubén Dittus Benavente

    2015-12-01

    Full Text Available El artículo presenta el marco teórico para estudiar los modelos de guion en el cine chileno de ficción. La literatura publicada y el creciente interés en la formación de guionistas en la industria audiovisual, tanto en Chile como en el extranjero, dan cuenta de la necesidad de abordar los principios dramatúrgicos y los estándares profesionales desde una mirada integradora, que supere los clásicos modelos de escritura creativa. Más allá de las divergencias o acuerdos de dichas teorías, el guionista -por aceptación o negación- pareciera que no puede obviar las influencias de algunas reglas básicas de estructura narrativa.

  18. Waste management for spent resin from Reactor Experimental Chileno number-sign 1 (RECH-1)

    International Nuclear Information System (INIS)

    A strategy is reported to find a waste form for temporary storage of spent resin arising from Reactor Experimental Chileno No. 1, RECH-1, according to radioactive waste management principles. As a first step, activity levels and contributions from long-lived fission products is obtained. The method that is developed is used to quantify the radioisotopes present in the resin to be allowed to follow them in the radioactive waste studies. As the activity is low, it is possible to find a way to dispose of large quantities of resin per drum. Two different processes were investigated: a mixtures technique and the double container immobilization method. Both were tested at laboratory and pilot plant scales. Results indicate that the double container method achieves great savings in economy of the management of spent resins

  19. Screening de trastornos de estrés postraumático en población afectada por el terremoto chileno de 2010

    Directory of Open Access Journals (Sweden)

    Roberto Ariel Abeldaño

    2014-11-01

    Full Text Available Se analizó un screening de trastornos de estrés postraumático en habitantes chilenos, como consecuencia del terremoto de febrero de 2010; a partir de una Encuesta Post Terremoto con una muestra multietápica de 24.982 personas mayores de 18 años, a quienes se aplicó la Escala de Trauma de Davidson. La prevalencia de screening positivo para los trastornos de estrés postraumático fue del 11% en el país, pero a menor nivel de desagregación llegaron a observarse prevalencias del 30%. El modelo de regresión logística para la estimación de la variable trastornos de estrés postraumático identificó como factores de riesgo el hecho de pertenecer un hogar pobre, haber sufrido daños en la vivienda, haber tenido algún problema de salud en el último mes y ser mujer (p<0,05. También se encontró que el afrontamiento del sismo en familia resultó como un factor protector, en relación a afrontarlo con otros colectivos sociales (vecinos, la mayor cantidad de años de educación formal también fue identificada como un factor de protección (p<0,05. Se observaron claras desigualdades sociales en las personas que presentaron un screening positivo.

  20. Self-Description Questionnaire II (versión breve: evidencia de fiabilidad y validez en una muestra de adolescentes chilenos

    Directory of Open Access Journals (Sweden)

    Nelly Lagos-San Martín

    2016-01-01

    Full Text Available El objetivo de este estudio fue analizar la fiabilidad y validez de las puntuaciones de la versión breve del Self-Description Questionnaire II (SDQ-II-S en población chilena. La muestra se compuso de 1255 adolescentes chilenos, con un rango de edad de 13 a 17 a ̃ nos (M = 15.10; DT = 1.30. El análisis factorial confirmatorio corroboró la estructura original de 11 factores correlacionados del SDQ-II-S. La multidimensionalidad del cuestionario también fue avalada por la peque ̃ na magnitud de las correlaciones entre los 11 factores (M = 0.26. Los coeficientes alfa de Cronbach variaron desde 0.70 hasta 0.84, y se destacó una adecuada fiabi- lidad. Para profundizar en el análisis de la validez de constructo del SDQ-II-S, se relacionaron las puntuaciones de las diferentes escalas con puntuaciones en medidas de ansiedad (Inven- tario de Ansiedad Estado-Rasgo y autoeficacia (Escala de Autoeficacia Percibida Específica de Situaciones Académicas. Los resultados pusieron de manifiesto que estos cuestionarios permi- ten analizar constructos diferenciados aunque relacionados. Los datos de este trabajo destacan que el SDQ-II-S presenta adecuadas propiedades psicométricas en población chilena, contrarres- tando las carencias existentes en lo que respecta a la evaluación del autoconcepto, y resaltan interesantes aplicaciones tanto en el ámbito aplicado como en el de la investigación.

  1. El mercado hidrotérmico chileno: un enfoque de teoría de juegos

    Directory of Open Access Journals (Sweden)

    Villena Mauricio

    2006-12-01

    \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\";">Este trabajo analiza los efectos y consecuencias potenciales de la desregulación del mercado chileno de generación eléctrica. Propone un modelo del sistema de generación que aplica la teoría de juegos no cooperativos en un contexto estático y dinámico. En Chile se han hecho estudios similares para sistemas puramente térmicos, donde las decisiones de operación sólo dependen de los costos de combustible y otros costos operativos, lo que permite usar modelos estáticos. Las centrales hidráulicas añaden una nueva e importante dimensión que se debe incorporar en el modelo: el uso del agua y la fuerte dependencia temporal de las decisiones, lo que implica el uso de modelos dinámicos. Este trabajo es un primer intento de elaborar un modelo dinámico del sistema hidrotérmico chileno. El modelo es genérico y se puede utilizar para simular un sistema hidrotérmico basado en una Bolsa de energía. La pérdida de generalidad se evita suponiendo que las centrales térmicas e hidráulicas pueden hacer ofertas a la Bolsa y comportarse estratégicamente.

  2. Breast Cancer in Systemic Lupus Erythematosus

    DEFF Research Database (Denmark)

    Tessier Cloutier, B; Clarke, A E; Ramsey-Goldman, R;

    2013-01-01

    Evidence points to a decreased breast cancer risk in systemic lupus erythematosus (SLE). We analyzed data from a large multisite SLE cohort, linked to cancer registries.......Evidence points to a decreased breast cancer risk in systemic lupus erythematosus (SLE). We analyzed data from a large multisite SLE cohort, linked to cancer registries....

  3. Asymptomatic Pulmonary Hypertension in Systemic Lupus Erythematosus

    OpenAIRE

    Kamel, Shereen R.; Omar, Gihan M.; Darwish, Ayman F.; Asklany, Hany T.; Abdou S. Ellabban

    2011-01-01

    Introduction: Pulmonary arterial hypertension (PAH) is a serious and often fatal complication of systemic lupus erythematosus (SLE). Because the diagnosis of PAH often is made years after symptom onset, early diagnostic strategies are essential. Doppler echocardiography currently is considered the noninvasive screening test of choice for evaluating pulmonary hypertension. Aim: Screening for asymptomatic pulmonary hypertension in systemic lupus erythematosus patients using Doppler echocardiogr...

  4. Biomarkers for Lupus Nephritis: A Critical Appraisal

    Directory of Open Access Journals (Sweden)

    Chi Chiu Mok

    2010-01-01

    Full Text Available Kidney disease is one of the most serious manifestations of systemic lupus erythematosus (SLE. Despite the improvement in the medical care of SLE in the past two decades, the prognosis of lupus nephritis remains unsatisfactory. Besides exploring more effective but less toxic treatment modalities that will further improve the remission rate, early detection and treatment of renal activity may spare patients from intensive immunosuppressive therapies and reduce renal damage. Conventional clinical parameters such as creatinine clearance, proteinuria, urine sediments, anti-dsDNA, and complement levels are not sensitive or specific enough for detecting ongoing disease activity in the lupus kidneys and early relapse of nephritis. Thus, novel biomarkers are necessary to enhance the diagnostic accuracy and sensitivity of lupus renal disease, prognostic stratification, monitoring of treatment response, and detection of early renal flares. This paper reviews promising biomarkers that have recently been evaluated in longitudinal studies of lupus nephritis.

  5. Lupus mastitis - peculiar radiological and pathological features

    International Nuclear Information System (INIS)

    Lupus mastitis is a form of lupus profundus that is seen in patients with systemic lupus erythematosus. It usually presents as a swelling (or swellings) in the breasts, with or without pain. The condition is recurrent and progresses along with the underlying disease, with fat necrosis, calcification, fibrosis, scarring, and breast atrophy. Lupus mastitis is often confused with malignancy and lymphoma and, in our part of the world, with tuberculosis. Confusion is especially likely when it occurs in an unusual clinical setting. In this article, we present a case that presented with unique radiological, pathological, and clinical features. Awareness of the various manifestations of lupus mastitis is essential if unnecessary interventions such as biopsies and surgeries, and their consequences, are to be avoided

  6. Th Subset Balance in Lupus Nephritis

    Directory of Open Access Journals (Sweden)

    Katsuhisa Miyake

    2011-01-01

    Full Text Available Lupus nephritis, which has various histological patterns and variable clinical outcomes, is one of the most important complications of systemic lupus nephritis (SLE. This pathogenetic mechanism in each histologically different type of lupus nephritis (LN remains unclear. Although SLE is suggested to be a Th2-driven disease, elevation of both Th1 and Th2 cytokines occurs in both humans and mice, suggesting that SLE is a complex disease driven by different lymphocyte subsets with high heterogeneity of clinical manifestations and organ involvement. Recent findings in LN elucidate an essential role for the Th1, IL-17 producing T cells and Th17 cells in the development of diffuse proliferative lupus nephritis (DPLN, and Th2 cytokine in that of membranous lupus nephritis (MLN. These data support the hypothesis that individual Th1/Th2 balance is one of the critical determinants for histopathology of LN.

  7. Lupus cerebritis after visiting a tanning salon.

    Science.gov (United States)

    Geara, Abdallah S; Torbey, Estelle; El-imad, Badiaa

    2009-01-01

    A 53-year-old female was admitted to the intensive care unit for lupus cerebritis; she had a 15-year history of stable lupus. Over the prior 1 to 2 months, the patient visited a tanning salon and this triggered the exacerbation of lupus. Her initial symptoms were cutaneous in the form of an erythematous rash. Within 2 weeks she started to have headaches and was admitted for seizure and psychosis. Ultraviolet A exposure in the tanning salon is known to exacerbate lupus by modulation of the immune system at the level of the skin. It has also been found that ultraviolet light can lead to the formation of antinuclear antibodies. This case illustrates the need to emphasize the danger of the tanning salon to patients with systemic lupus erythematous; the risk is not only cutaneous, it can also be systemic. PMID:20001946

  8. Patrones de uso de servicios entre adultos con problemas de salud mental, en Chile Service use patterns among adults with mental health problems in Chile

    OpenAIRE

    Benjamín Vicente; Robert Kohn; Sandra Saldivia; Pedro Rioseco; Silverio Torres

    2005-01-01

    OBJETIVO: Describir el patrón de uso de servicios generales y especializados entre los adultos con problemas de salud mental, así como su nivel de satisfacción con dichos servicios, con la finalidad de contribuir a optimizar los escasos recursos disponibles en la Región para la atención de la salud mental, particularmente en lo que corresponde a Chile. MÉTODO: Los diagnósticos y los patrones de uso de los servicios de salud mental se obtuvieron del Estudio Chileno de Prevalencia Psiquiátrica ...

  9. Servicios residenciales para personas con discapacidad intelectual en Chile. Avanzando hacia las buenas prácticas

    OpenAIRE

    Vega, Vanessa; Jenaro, Cristina; Flores, Noelia; Cruz, Maribel; Morrillo, María Luz

    2013-01-01

    El presente estudio pretende conocer la visión y prácticas de proveedores de servicios sobre la atención proporcionada y su relación con los apoyos y calidad de vida de chilenos con discapacidad intelectual institucionalizados. La metodología utilizada ha consistido en el análisis de contenido de la información proporcionada por tres grupos focales compuestos por proveedores de servicios. Los resultados indican que, si bien se está avanzando en la calidad de los servicios ofrecidos para estos...

  10. El Derecho a la Tutela Judicial y al Debido Proceso en la Jurisprudencia del Tribunal Constitucional Chileno

    OpenAIRE

    Gonzalo García Pino; Pablo Contreras Vásquez

    2013-01-01

    El texto propone un esquema conceptual que sistematiza la jurisprudencia del Tribunal Constitucional chileno en materia del derecho a la tutela judicial y al debido proceso. Tomando en consideración la doctrina reciente, el texto elabora categorías dogmáticas para diferenciar las potestades y componentes del derecho a la tutela judicial del debido proceso. Los autores concluyen que ambos derechos son de creciente desarrollo conceptual por la jurisprudencia constitucional chilena y que su sist...

  11. Estudio de los textos de Historia y de Ciencias Sociales chilenos entre 2000 y 2010 Estudo dos textos de historia e de ciências sociais chilenos entre 2000 e 2010 Study of Chilean History and Social Science Textbooks between 2000 and 2010

    Directory of Open Access Journals (Sweden)

    Raquel Soaje-de Elias

    2012-04-01

    Full Text Available Analizar la calidad de los textos de Historia y de Ciencias Sociales, entregados por el Ministerio de Educación chileno a los estudiantes de establecimientos oficiales y subvencionados, es el objetivo de este trabajo. Se examinaron 35 textos editados entre 2000 y 2010. En la investigación de aplicó una encuesta a docentes de colegios subvencionados y de realizaron cuatro "focusgroup" con docentes de colegios particulares de alta calidad. En el estudio se tuvieron en cuenta las siguientes variables-, estructura y organización, contenido y metodología de los libros y se concluyó que sus contenidos presentan falencias, que se deben revisar para optimizar su uso como herramienta fundamental en el proceso de enseñanza y aprendizaje.Analisar a qualidade dos textos de história e de ciências sociais, entregues pelo Ministério da Educação chileno aos estudantes de estabelecimentos oficiais e subsidiados, é o objetivo deste trabalho. Examinaram-se 35 textos editados entre 2000 e 2010. Na pesquisa se aplicou uma enquête com docentes de colégios subsidiados e se realizaram quatro "focusgroup"com docentes de colégios particulares de alta qualidade. No estudo se consideraram as seguintes variáveis: estrutura e organização, conteúdo e metodología dos livros. Concluiu-se que seus conteúdos apresentam falências que se devem revisar para melhorar seu uso como ferramenta fundamental no processo de ensino e aprendizagem.The objective of this study was to analyze the quality of history and social science textbooks provided by the Chilean Ministry of Education to students at public and subsidized schools. Fifteen (is textbooks published between 2000 and 2010 were examined for that purpose. Teachers at subsidized schools were surveyed and four focus groups were conducted with teachers from several top-rated private schools. The study took into account the following variables-, structure and organization, content and methodology of the textbooks

  12. Improving Outcomes in Patients with Lupus and End Stage Renal Disease

    OpenAIRE

    Inda-Filho, Antonio; Neugarten, Joel; Putterman, Chaim; Broder, Anna

    2013-01-01

    The development of lupus-related end stage renal disease (ESRD) confers the highest mortality rates among individuals with lupus. Lupus-related ESRD is also associated with higher morbidity and mortality rates compared with non-lupus ESRD.

  13. RUPTURA CON EL EJE Y ALINEAMIENTO CON ESTADOS UNIDOS: CHILE DURANTE LA SEGUNDA GUERRA MUNDIAL

    Directory of Open Access Journals (Sweden)

    Raffaele Nocera

    2005-12-01

    Full Text Available En este trabajo se avanza más allá en la investigación de un tema que ya ha sido objeto de otros estudios. Se entrega un análisis pormenorizado de la posición de Chile ante el origen y primer desarrollo de la Segunda Guerra Mundial. Aunque se destacan las relaciones con EE.UU., en base principalmente a un amplio estudio de archivos chilenos y norteamericanos, se analiza la situación tanto política como económica del país en relación a la guerra. El artículo vincula las relaciones de Chile con Estados Unidos a la luz de sus propias relaciones con el conflicto europeo, y particularmente con la Alemania naziThis study advances the research of a field, which already has been subyect of other works. There is a detailed analysis on Chile's position in front of the origins and in the first stage of the Second World War. There is an emphasis on relations with the U.S., based on Chilean and American archives, on the economic and political attitudes on the war. The article links the relations between Chile and the U.S. under the light of Chilean relations with the European conflict and, specially, Nazi Germany

  14. Belimumab in systemic lupus erythematosus

    Science.gov (United States)

    Vilas-Boas, Andreia; Morais, Sandra A; Isenberg, David A

    2015-01-01

    Systemic lupus erythematosus (SLE) is one of the most challenging autoimmune disorders with a complex pathophysiology and diverse clinical presentation. Many drugs have been used to treat SLE with suboptimal results, especially in patients with moderate-to-severe disease. Belimumab is the first biological drug to be approved for the treatment of SLE in more than 50 years. This monoclonal antibody blocks B-cell activating factor, a cytokine important for B-cell differentiation and survival. In this review we focus on the activity of belimumab in patients with SLE and discuss the controversies of its use. PMID:26509047

  15. Cross-fostering in gray wolves (Canis lupus lupus).

    Science.gov (United States)

    Scharis, Inger; Amundin, Mats

    2015-01-01

    Cross-fostering in canids, with captive-bred pups introduced into endangered wild populations, might aid conservation efforts by increasing genetic diversity and lowering the risk of inbreeding depression. The gray wolf (Canis lupus lupus) population in Scandinavia suffers from severe inbreeding due to a narrow genetic base and geographical isolation. This study aimed at evaluating the method to cross-foster wolf pups from zoo-born to zoo-born litters. The following was assessed: female initial acceptance of foster pups, growth rate in relation to age difference between foster pups and pups in recipient litters and survival over the first 33 weeks. The study included four litters added by two foster pups in each. The age differences between the foster pups and the recipient litters were 2-8 days. After augmentation, all four females accepted the foster pups, demonstrated by her moving the entire litter to a new den site. Growth rate was dependent on the age difference of the pups in the foster litters, with a considerably slower growth rate in the 8 days younger pups. However, these pups later appeared to be at no disadvantage. Foster pups had a higher survival rate than females' pups, however, the causes of death were probably not kin or non-kin related. The results indicate that cross-fostering works in gray wolves and that this might be a plausible way to increase genetic variation in the wild population. PMID:25773058

  16. The persistent challenge of lupus nephritis.

    Science.gov (United States)

    Valesini, Guido; Conti, Fabrizio

    2011-06-01

    Systemic lupus erythematosus has long been considered the prototypic autoimmune disease. Although the etiology remains enigmatic, there has been vigorous definition of the clinical features and the natural history. In this issue, we review the persistent challenge of lupus nephritis and, in particular, features of diagnosis as well as treatment options. It is clear that major therapeutic advances have occurred but there is still a considerable unmet need in the population. This issue does not review all the clinical problems of lupus nephritis, but rather attempts to place the most recent data in perspective for the clinician. PMID:20811786

  17. Teuto-argentino, teuto-brasileiro, teuto-chileno: identidades em debate

    Directory of Open Access Journals (Sweden)

    Rambo, Arthur Blasio

    2005-01-01

    Full Text Available Durante o século dezenove e no decorrer das primeiras décadas do século vinte, foram implantados projetos de colonização alemã no Brasil, na Argentina e no Chile. Apresentavam-se com semelhanças muito grandes nos três países, tanto nos objetivos, como no modelo de estrutura agrária, como na organização das comunidades rurais. Merece ser destacado neste processo a ocupação de grandes regiões mediante um povoamento maciço de exclusiva etnia alemã. Os imigrantes e seus descendentes das primeiras gerações permaneceram fiéis à língua e à tradição alemã. Na condição, porém, de cidadãos dos respectivos países foram sendo assimilados lentamente na sociedade maior que compunham a nação argentina, brasileira ou chilena. Desta situação ambígua, originou-se, a partir da década de 1930, uma discussão em todos os níveis, em torno da interrogação: Depois de duas, três ou até quatro gerações, o que somos, qual a nossa identidade, ainda somos alemães e em que sentido, até que ponto já somos chilenos, argentinos ou brasileiros? Ou, quem sabe nos resumimos a não sermos mais o que fomos e ainda não sermos aquilo que deveremos ser no futuro? Em outras palavras: o que entende o imigrante alemão no Chile quando se autodenomina de teuto-chileno, o imigrante alemão na Argentina, quando se denomina de teuto-argentino, ou o imigrante alemão no Brasil, quando se denomina teuto-brasileiro?

  18. EL NUEVO ILÍCITO DE ACOSO SEXUAL EN EL DERECHO DEL TRABAJO CHILENO: the new form of illegality in Chilean labour law Sexual harassment

    Directory of Open Access Journals (Sweden)

    Claudio Palavecino Cáceres

    2006-07-01

    Full Text Available En este trabajo se plantea un análisis crítico del nuevo ilícito de acoso sexual introducido en el orden jurídico chileno por la Ley N ° 20.005/2005. Se trata de responder a la pregunta si la tutela que ofrece la nueva regulación es adecuada y suficiente para prevenir, sancionar y reparar los efectos lesivos del acoso sexual laboral. Se procura definir un concepto material del fenómeno. Al contrastar tal concepto con la noción jurídico-normativa, se detecta un déficit en la tipificación legal que deja fuera una parte significativa de los actos de acoso. Se analizan los distintos mecanismos de protección, incluido el nuevo procedimiento de tutela de los derechos fundamentales. Se concluye que, si bien la nueva legislación constituye un avance en esta materia, contiene deficiencias de técnica jurídica que pueden tornarla inoperante.This paper presents a critical examination of sexual harassment, a new form of illegality introduced in the Chilean legal system by Law Nº 20.005 /2005. The aim of the article is to determine if the protection offered by this new legislation is adequate and sufficient to prevent, punish and repair the harmful effects produced by sexual harassment in the workplace. The author tries to conceptualize the reality of sexual harassment. When confronting the concept with the legal definition of the phenomenon, the author finds that the legal definition is under inclusive, because it does not cover significant number of conducts involving harassment. The paper examines the variety of protection mechanisms, including the new judicial procedure of protection of fundamental rights. The author concludes that, although the new legislation represents an improvement on the subject, it could be difficult to enforce due to the imperfections of its legal technique.

  19. 2007 Changsha International Symposium on Lupus

    Institute of Scientific and Technical Information of China (English)

    LU Qian-jin; LI Ya-ping

    2007-01-01

    @@ The 2007 Changsha International Symposium on Lupus, co-sponsored by the Institute of Dermatovenereology and the Epigenetic Research Center of the Second Xiangya Hospital at the Central South University was successfully held in Changsha on May 27,2007.

  20. Lupus vulgaris with tuberculosis verrucosa cutis

    Directory of Open Access Journals (Sweden)

    Prasad PVS

    1994-01-01

    Full Text Available 26 years old male presented with two large plaques of lupus vulgaris and a lesion of tuberculosis verrucosa cutis on the right thigh and foot, respectively. Both the lesions were confirmed by histopathological examinations.

  1. Lupus vulgaris with tuberculosis verrucosa cutis

    OpenAIRE

    Prasad PVS; Padmavathy L; Kumar Prasanna; Rao L

    1994-01-01

    26 years old male presented with two large plaques of lupus vulgaris and a lesion of tuberculosis verrucosa cutis on the right thigh and foot, respectively. Both the lesions were confirmed by histopathological examinations.

  2. Natural history of "silent" lupus nephritis.

    Science.gov (United States)

    Bennett, W M; Bardana, E J; Norman, D J; Houghton, D C

    1982-05-01

    Twenty patients with systemic lupus erythematosus but without evident renal involvement previously underwent percutaneous renal biopsy. Findings revealed almost universal pathologic evidence of nephritis. Included were three patients who had diffuse proliferative changes and five who had subendothelial electron dense deposits. Only four patients developed clinical renal disease during the follow-up period while no patient died or required dialysis. Using the Life Table Method, the cumulative percentage of patients free from any clinical renal disease was over 60% at 10 yr from the time of diagnosis of systemic lupus, and at 8 yr from the time of the original biopsy. It is concluded that silent lupus nephritis, regardless of histologic subtype, has a favorable prognosis. These data may not be applicable to patients with similar biopsies who have evidence of clinical lupus nephritis. PMID:7091151

  3. Anaplastic myeloma in systemic lupus erythematosus.

    Science.gov (United States)

    Butler, R C; Thomas, S M; Thompson, J M; Keat, A C

    1984-01-01

    We describe a patient with systemic lupus erythematosus who developed an unusual form of anaplastic myeloma. Possible relationships between the two disease, and the role played by immunosuppressive therapy, are discussed. Images PMID:6476924

  4. What Medications Are Used to Treat Lupus?

    Science.gov (United States)

    ... only medication they need to control their lupus. Aspirin Pain-reducer with anti-inflammatory and anticoagulant (blood- ... may damage the retina of the eye (retinal toxicity), causing vision problems. If low doses of antimalarials ...

  5. Methylprednisolone pulse therapy for nonrenal lupus erythematosus.

    OpenAIRE

    Eyanson, S; Passo, M H; Aldo-Benson, M A; Benson, M D

    1980-01-01

    High-dose intravenous methylprednisolone therapy has previously been shown to be efficacious in the treatment of renal lupus erythematosus. The present report presents 2 patients with life-threatening, nonrenal lupus erythematosus. One patient had coma and seizures, while the other had sever thrombocytopenia and anaemia. Both had failed to respond to oral corticosteroid therapy in high doses but had dramatic clinical responses with intravenous methylprednisolone given in 'pulses.' Possible me...

  6. Lupus-erythematous-associated interstitial granulomatous dermatitis.

    Science.gov (United States)

    Marmon, Shoshana; Robinson, Maria; Meehan, Shane A; Franks, Andrew G

    2012-12-01

    A 41-year-old woman with a prior diagnosis of lupus erythematous presented with a five-year history of small, erythematous, flesh-colored papules and nodules that coalesced into symmetrically-distributed plaques on her upper back. A biopsy specimen showed an interstitial, granulomatous mixed-cell dermatitis with eosinophils. These clinicopathologic findings are consistent with a diagnosis of lupus erythematous-associated interstitial granulomatous dermatitis. PMID:23286821

  7. Radiological changes in systemic lupus erythematosis

    International Nuclear Information System (INIS)

    In a study of 50 patients with systemic lupus erythematosis, radiologically demonstrable lung changes and pleural effusions were found in 50%. Changes in the peripheral skeleton, such as osteoporosis, erosions or mutilations, were seen in only two patients. Our radiological analysis has shown that systemic lupus erythematosis does not produce changes in the joints, but is responsible for abnormalities in the lungs, as well as for pericardial and pleural effusions. (orig.)

  8. Neonatal lupus syndrome in a Nigerian child

    OpenAIRE

    Abiodun, Moses; Adelowo, Olufemi

    2012-01-01

    Neonatal lupus is a rare syndrome resulting from passively transferred maternal autoantibodies during pregnancy. A male infant was delivered at term to a 29-year-old primiparous woman who was diagnosed of systemic lupus erythematosus 2 years earlier and had detectable levels of autoantibodies (antinuclear antibody (ANA), anti-dsDNA, anti-Ro and anti-La/SSB) in second trimester. However, the pregnancy was otherwise uneventful. He presented at the age of 8 week with a widespread hypopigmented m...

  9. Neuropsychiatric lupus: a mosaic of clinical presentations

    OpenAIRE

    Kivity, Shaye; Agmon-Levin, Nancy; Zandman-Goddard, Gisele; Chapman, Joab; Shoenfeld, Yehuda

    2015-01-01

    Neuropsychiatric symptoms affect nearly half of the patients with systemic lupus erythematosus; however, the effect on disease severity, quality of life, and prognosis is tremendous. Symptoms of neuropsychiatric systemic lupus erythematosus may range from mild diffuse ones, to acute life threatening events. Although the underlying mechanisms are still largely unraveled, several pathogenic pathways are identified, such as antibody-mediated neurotoxicity, vasculopathy due to anti-phospholipid a...

  10. Biomarkers for Lupus Nephritis: A Critical Appraisal

    OpenAIRE

    Chi Chiu Mok

    2010-01-01

    Kidney disease is one of the most serious manifestations of systemic lupus erythematosus (SLE). Despite the improvement in the medical care of SLE in the past two decades, the prognosis of lupus nephritis remains unsatisfactory. Besides exploring more effective but less toxic treatment modalities that will further improve the remission rate, early detection and treatment of renal activity may spare patients from intensive immunosuppressive therapies and reduce renal damage. Conventional clini...

  11. Recurrence of Lupus Nephritis after Kidney Transplantation

    OpenAIRE

    Contreras, Gabriel; Mattiazzi, Adela; Guerra, Giselle; Ortega, Luis M.; Tozman, Elaine C.; Li, Hua; Tamariz, Leonardo; Carvalho, Cristiane; Kupin, Warren; Ladino, Marco; Leclercq, Baudouin; Jaraba, Isabel; Carvalho, Decio; Carles, Efrain; Roth, David

    2010-01-01

    The frequency and outcome of recurrent lupus nephritis (RLN) among recipients of a kidney allograft vary among single-center reports. From the United Network for Organ Sharing files, we estimated the period prevalence and predictors of RLN in recipients who received a transplant between 1987 and 2006 and assessed the effects of RLN on allograft failure and recipients' survival. Among 6850 recipients of a kidney allograft with systemic lupus erythematosus, 167 recipients had RLN, 1770 experien...

  12. Lupus eritematoso discóide na infância Discoid lupus erythematosus in childhood

    Directory of Open Access Journals (Sweden)

    Maria Carolina de A. Sampaio

    2007-06-01

    Full Text Available OBJETIVO: Realizar revisão da literatura sobre o lupus eritematoso discóide (LED na infância. FONTES DE DADOS: Livros-texto e artigos de revistas indexadas pelo Medline e SciELO nos últimos dez anos, usando as seguintes palavras-chave: "discoid lupus erythematosus", "chronic cutaneous lupus erythematosus", "lupus erythematosus in childhood", "lupus erythematosus in children", "discoid lupus erythematosus in childhood", "discoid lupus erythematosus in children". SÍNTESEDOS DADOS: A idade de início da doença ocorre predominantemente entre cinco e dez anos e a história familiar de lupus eritematoso está presente em 11 a 35% dos casos. A relação gênero feminino/masculino varia de 1/1 a 2,4/1. Por sua vez, 24 a 27% dos pacientes com LED desenvolvem lupus eritematoso sistêmico (LES. Lesões discóides localizadas (que acometem cabeça e pescoço são observadas em 56 a 75% dos pacientes. A face é o local mais acometido. O LED localizado e o generalizado apresentam evolução semelhante. Os achados histológicos são típicos, mostrando dermatite de interface. IgM e IgG são os depósitos mais freqüentes na zona da membrana basal da epiderme. Os tratamentos geralmente utilizados são: fotoproteção, corticosteróides tópicos e antimaláricos. Imunossupressores, talidomida, dapsona e retinóides podem ser usados nos casos refratários. CONCLUSÕES: O LED da infância parece ter pequeno predomínio no gênero feminino, alta prevalência de história familiar de lupus eritematoso e elevada proporção que evolui para a forma sistêmica da doença, comparada ao LED do adulto. O LED localizado e o generalizado apresentam prognósticos semelhante. Os achados histológicos não foram diferentes daqueles descritos no LED do adulto.OBJECTIVE: To review the literature about discoid lupus erythematosus (DLE in childhood. DATA SOURCES: Textbooks and journals indexed for Medline and SciELO in the last ten years. The following key-words were

  13. Propuestas para la formación en educación en medios en profesores chilenos Criteria of Media Education Program for Chilean teachers: A proposal for Continuous Training

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    María del Mar de Fontcuberta Balaguer

    2009-03-01

    Full Text Available Este trabajo, desarrollado por un grupo de investigación chileno, expone los resultados de una investigación sobre la presencia de la educación en medios en el currículum de la enseñanza media chilena, los problemas que plantea y la formación y actitudes de los profesores de Lengua Castellana y Comunicación en ese ámbito. Para su análisis adopta las definiciones y parámetros contemplados por la UNESCO en Viena (1999 y Sevilla (2002 que indican, entre otros aspectos, que la educación en medios trata sobre la enseñanza y el aprendizaje «con» y «sobre» los medios, más que «a través» de los medios. El estudio concluye con una propuesta para implementar la formación continua de profesores en ese campo. The article explains the results of a research about Media Education in Chilean Secondary School curriculum, its problems, and training and attitudes of teachers of Spanish Language and Communication. The analysis applies definitions and parameters adopted by UNESCO in Viena (1999 and Seville (2002 which indicate that Media Education means to teach and learn «with»» and «about» media more than «through» media. It proposes a schedule for continuous training of teachers in this field.

  14. Antiphospholipid Antibodies in Lupus Nephritis.

    Science.gov (United States)

    Parodis, Ioannis; Arnaud, Laurent; Gerhardsson, Jakob; Zickert, Agneta; Sundelin, Birgitta; Malmström, Vivianne; Svenungsson, Elisabet; Gunnarsson, Iva

    2016-01-01

    Lupus nephritis (LN) is a major manifestation of systemic lupus erythematosus (SLE). It remains unclear whether antiphospholipid antibodies (aPL) alter the course of LN. We thus investigated the impact of aPL on short-term and long-term renal outcomes in patients with LN. We assessed levels of aPL cross-sectionally in SLE patients diagnosed with (n = 204) or without (n = 294) LN, and prospectively in 64 patients with active biopsy-proven LN (52 proliferative, 12 membranous), before and after induction treatment (short-term outcomes). Long-term renal outcome in the prospective LN cohort was determined by the estimated glomerular filtration rate (eGFR) and the Chronic Kidney Disease (CKD) stage, after a median follow-up of 11.3 years (range: 3.3-18.8). Cross-sectional analysis revealed no association between LN and IgG/IgM anticardiolipin or anti-β2-glycoprotein I antibodies, or lupus anticoagulant. Both aPL positivity and levels were similar in patients with active LN and non-renal SLE. Following induction treatment for LN, serum IgG/IgM aPL levels decreased in responders (p<0.005 for all), but not in non-responders. Both at active LN and post-treatment, patients with IgG, but not IgM, aPL had higher creatinine levels compared with patients without IgG aPL. Neither aPL positivity nor levels were associated with changes in eGFR from either baseline or post-treatment through long-term follow-up. Moreover, aPL positivity and levels both at baseline and post-treatment were similar in patients with a CKD stage ≥3 versus 1-2 at the last follow-up. In conclusion, neither aPL positivity nor levels were found to be associated with the occurrence of LN in SLE patients. However, IgG aPL positivity in LN patients was associated with a short-term impairment of the renal function while no effect on long-term renal outcome was observed. Furthermore, IgG and IgM aPL levels decreased following induction treatment only in responders, indicating that aPL levels are affected by

  15. Antiphospholipid Antibodies in Lupus Nephritis.

    Directory of Open Access Journals (Sweden)

    Ioannis Parodis

    Full Text Available Lupus nephritis (LN is a major manifestation of systemic lupus erythematosus (SLE. It remains unclear whether antiphospholipid antibodies (aPL alter the course of LN. We thus investigated the impact of aPL on short-term and long-term renal outcomes in patients with LN. We assessed levels of aPL cross-sectionally in SLE patients diagnosed with (n = 204 or without (n = 294 LN, and prospectively in 64 patients with active biopsy-proven LN (52 proliferative, 12 membranous, before and after induction treatment (short-term outcomes. Long-term renal outcome in the prospective LN cohort was determined by the estimated glomerular filtration rate (eGFR and the Chronic Kidney Disease (CKD stage, after a median follow-up of 11.3 years (range: 3.3-18.8. Cross-sectional analysis revealed no association between LN and IgG/IgM anticardiolipin or anti-β2-glycoprotein I antibodies, or lupus anticoagulant. Both aPL positivity and levels were similar in patients with active LN and non-renal SLE. Following induction treatment for LN, serum IgG/IgM aPL levels decreased in responders (p<0.005 for all, but not in non-responders. Both at active LN and post-treatment, patients with IgG, but not IgM, aPL had higher creatinine levels compared with patients without IgG aPL. Neither aPL positivity nor levels were associated with changes in eGFR from either baseline or post-treatment through long-term follow-up. Moreover, aPL positivity and levels both at baseline and post-treatment were similar in patients with a CKD stage ≥3 versus 1-2 at the last follow-up. In conclusion, neither aPL positivity nor levels were found to be associated with the occurrence of LN in SLE patients. However, IgG aPL positivity in LN patients was associated with a short-term impairment of the renal function while no effect on long-term renal outcome was observed. Furthermore, IgG and IgM aPL levels decreased following induction treatment only in responders, indicating that aPL levels are

  16. Topical calcineurin inhibitors in systemic lupus erythematosus

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    Christos E Lampropoulos

    2010-04-01

    Full Text Available Christos E Lampropoulos, David P D’CruzLupus Research Unit, Rayne Institute, St. Thomas’ Hospital, London, UKAbstract: Cutaneous lupus erythematosus (CLE encompasses a variety of lesions that may be refractory to systemic or topical agents. Discoid lupus erythematosus (DLE and subacute cutaneous lupus erythematosus (SCLE are the most common lesions in clinical practice. The topical calcineurin inhibitors, tacrolimus and pimecrolimus, have been used to treat resistant cutaneous lupus since 2002 and inhibit the proliferation and activation of T-cells and suppress immune-mediated cutaneous inflammation. This article reviews the mechanism of action, efficacy, adverse effects, and the recent concern about their possible carcinogenic effect. Although the total number of patients is small and there is only one relevant randomized controlled study, the data are encouraging. Many patients, previously resistant to systemic agents or topical steroids, improved after four weeks of treatment. DLE and SCLE lesions were less responsive, reflecting the chronicity of the lesions, although more than 50% of patients still showed improvement. Topical calcineurin inhibitors may be a safe and effective alternative to topical steroids for CLE although the only approved indication is for atopic dermatitis.Keywords: tacrolimus, pimecrolimus, cutaneous lupus erythematosus, topical calcineurin inhibitors

  17. Pancreatitis and systemic lupus erythematosus Pancreatitis y lupus eritematoso sistémico

    Directory of Open Access Journals (Sweden)

    J. Lariño Noia

    2009-08-01

    Full Text Available Gastrointestinal symptoms in patients with SLE are common, specifically abdominal pain. However, the rate of pancreatic diseases is much lower and does not reach 5% according to published series in Europe and the USA. This association between SLE and pancreatic disease is basically at the expense of episodes of acute pancreatitis. An association with chronic pancreatitis is much more uncommon, and only four articles have been published showing this relationship. Three cases of SLE-associated pancreatitis are described, and disease onset, etiological factors, and clinical progression are analyzed. A review of the literature and a brief discussion about pathophysiological mechanisms and the role of corticosteroids are also included.Los síntomas gastrointestinales en los pacientes con lupus eritematoso sistémico (LES son comunes, específicamente el dolor abdominal. Sin embargo la tasa de enfermedades pancreáticas es mucho menor, una tasa que no alcanza ni al 5% según las series publicadas en Europa y EE. UU. Esta asociación entre enfermedades pancreáticas y LES es fundamentalmente a expensas de episodios de pancreatitis aguda. La asociación con pancreatitis crónica es muchísimo más infrecuente, teniendo en cuenta que tan sólo cuatro artículos han sido publicados reflejando esta asociación. Describimos tres casos de asociación entre pancreatitis y LES, analizando el debut de la enfermedad, los factores etiológicos y también la evolución clínica. Hemos realizado, además, una breve discusión de la fisiopatología y del papel de corticosteroides, así como una revisión de la literatura.

  18. Estructura social y modelos de «desarrollo»: el caso chileno

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    Xabier ARRIZABALO MONTORO

    2009-11-01

    Full Text Available RESUMEN: El artículo analiza la relación entre la estructura social y el modelo de desarrollo, específicamente para el caso chileno, durante la dictadura de Pinochet (1973-1990. Las políticas económicas puestas en marcha por el régimen militar, y continuadas en buen grado por el gobierno de la Concertación, responden a un enfoque neoliberal que apoya el fortalecimiento del capitalismo, a expensas de más desempleo y condiciones de vida más precarias para los trabajadores y los pobres.ABSTRACT: The article analyzes the relationship among social structure and strategy of development, specifically for the Chilean case, during Pinochet's dictatorship (1973-1990. The Political Economies implemented by the military regime, and continued in many grades for the Concertation government, respond to a neoliberal approach which support the improvement of the capitalism but at the expense of more unemployment and more precarious conditions of life for the workers and the poor.

  19. La cultura nacional y su impacto en los negocios: el caso chileno

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    Pedro Hidalgo Campos

    2007-01-01

    Full Text Available El objetivo de este artículo es analizar el impacto de la cultura nacional en los negocios. Uno de los investigadores más destacados en el análisis de la cultura nacional es Geert Hofstede (1980. Él identificó cuatro dimensiones de la cultura nacional: distancia de poder, aversión a la incertidumbre, individualismo y masculinidad. Fernández et al. (1997 midieron estas cuatro dimensiones en Chile, caracterizando a los chilenos en esas cuatro dimensiones. Revisando la evidencia empírica chilena, en este artículo se analizan los principales efectos que las dimensiones de Hofstede tienen en la administración, los recursos humanos y el marketing. Este artículo ofrece varios ejemplos de cómo las dimensiones culturales afectan las prácticas en las organizaciones y es un fuerte argumento para hacer consideraciones culturales en la planificación estratégica.

  20. Factores psicosociales del presentismo en trabajadores del Sistema de Salud chileno

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    Aldo Vera-Calzaretta

    2015-01-01

    Full Text Available Este estudio analizó los factores psicosociales que explicaban el presentismo o deterioro laboral autopercibido asociado a trabajar enfermo. La muestra fue de 676 trabajadores del sistema de salud chileno (84% de mujeres, M = 35.9 anos, en su mayoría enfermeras y técnicos paramédicos. Se aplicó un cuestiona- ˜ rio sociodemográfico, el Job Content Questionnaire, el Effort-Reward Imbalance, el Health Performance Questionnaire y una escala de interferencia del trabajo en la vida familiar. La regresión lineal explicó el 21% de la varianza del deterioro laboral percibido. Este último se asoció a asistir a trabajar enfermo. Los resultados sugieren que el deterioro del desempeno y asistir a trabajar enfermo son dos aspectos del ˜ mismo proceso. El ausentismo por razones de salud, la interferencia del trabajo en la vida familiar y la sintomatología emocional predijeron el deterioro laboral. Éste último se asoció negativamente a trabajar en turnos, controlando edad y salario. Los resultados sugieren que el presentismo es explicado por factores del contexto de trabajo y el conflicto trabajo-familia.

  1. Hydroxychloroquine and pregnancy on lupus flares in Korean patients with systemic lupus erythematosus.

    Science.gov (United States)

    Koh, J H; Ko, H S; Kwok, S-K; Ju, J H; Park, S-H

    2015-02-01

    We investigated the clinical and laboratory characteristics of pregnancies with systemic lupus erythematosus (SLE) and identified lupus flare predictors during pregnancy. Additionally, we examined lupus activity and pregnancy outcomes in SLE patients who continued, discontinued or underwent no hydroxychloroquine (HCQ) treatment during pregnancy. We retrospectively analyzed 179 pregnancies in 128 SLE patients at Seoul St. Mary's Hospital, Korea, between 1998 and 2012 and then assessed the clinical profiles and maternal and fetal outcomes. Overall, 90.5% of pregnancies resulted in a successful delivery and were divided into two groups: those who experienced lupus flares (80 pregnancies, 44.7%) and those who did not (99 pregnancies, 55.3%). Increased preeclampsia, preterm births, low birth weight, intrauterine growth restriction (IUGR), and low 1-minute Apgar scores occurred in pregnancies with lupus flares compared to pregnancies in quiescent disease. Lupus flares were predicted by HCQ discontinuation, a history of lupus nephritis, high pre-pregnancy serum uric acid and low C4 levels. Our study indicates that achieving pre-pregnancy remission and continuing HCQ treatment during pregnancy are important for preventing lupus flares. PMID:25305214

  2. Pregnancy complications in a patient with systemic lupus erythematosus and lupus nephritis

    DEFF Research Database (Denmark)

    Bisgaard, Helene; Jacobsen, Søren; Tvede, Niels;

    2014-01-01

    A woman with systemic lupus erythematosus (SLE) and lupus nephritis had two pregnancies which both resulted in complications known to be associated with SLE, i.e. late abortion, preterm delivery and pre-eclampsia. We conclude that disease quiescence is important for a successful outcome and that...

  3. Graviditetskomplikationer hos en patient med systemisk lupus erythematosus og lupus nefritis

    DEFF Research Database (Denmark)

    Bisgaard, Helene; Jacobsen, Søren; Tvede, Niels;

    2014-01-01

    A woman with systemic lupus erythematosus (SLE) and lupus nephritis had two pregnancies which both resulted in complications known to be associated with SLE, i.e. late abortion, preterm delivery and pre-eclampsia. We conclude that disease quiescence is important for a successful outcome and that...

  4. Dengue fever triggering systemic lupus erythematosus and lupus nephritis: a case report

    Directory of Open Access Journals (Sweden)

    Talib SH

    2013-10-01

    Full Text Available SH Talib, SR Bhattu, R Bhattu, SG Deshpande, DB Dahiphale Department of Medicine and Nephrology, MGM Medical College and Hospital, Aurangabad, Maharashtra, India Abstract: We report a rare case of dengue fever triggering systemic lupus erythematosus and lupus nephritis. The patient presented herself during a large outbreak of dengue fever in December 2012 in Maharashtra, India. The diagnosis of dengue fever was confirmed by the presence of NS-1 antigen during the first few days of febrile illness. Eight weeks later, kidney tissue biopsy studies revealed evidence of lupus nephritis on microscopic examination and immunofluorescence. The report interpreted it as focal proliferative glomerulonephritis and segmental sclerosis (Stage IIIC. The case was also found positive for perinuclear antineutrophil cytoplasmic antibodies by indirect immunofluorescence assay. An active and effective management of a case essentially calls for clear perception of differentiating dengue-induced lupus flare, antineutrophil cytoplasmic antibody-related nephropathy, and/or dengue-induced de-novo lupus disease. Dengue viremia may be the trigger for immune complex formation in patients who are predisposed to developing autoimmune diseases. The present case explains the importance of considering the diagnosis of dengue-related lupus nephritis as an atypical occurrence in appropriate situations, as in this case. It would not be improper to regard this escalating disease as an expanded feature of dengue. Keywords: kidney biopsy, glomerulonephritis, segmental sclerosis, lupus flare, dengue viremia, autoimmune, de-novo lupus nephritis

  5. Pain and systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    M. Di Franco

    2014-06-01

    Full Text Available Systemic lupus erythematosus (SLE is an autoimmune disease characterized by heterogeneous clinical manifestations involving virtually the entire body. The pain in SLE can have different causes. The SLE classification criteria include mainly the musculoskeletal manifestations of pain, which are commonly reported as initial symptoms of SLE, such as arthralgia, arthritis and/or myalgia. Chronic widespread pain, which is typical of fibromyalgia (FM, is frequently associated with SLE. The aim of this review is to describe widespread pain and fatigue in SLE, and the association of SLE and FM. Although secondary FM is not correlated with the disease activity, it may interfere with the daily activities of SLE patients. Therefore it is necessary to identify its symptoms and treat them promptly to improve the quality of life of patients. In conclusion, it is essential to identify the origin of pain in SLE in order to avoid dangerous over-treatment in patients with co-existing widespread pain and FM.

  6. OSTEOPOROSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS

    Directory of Open Access Journals (Sweden)

    N V Seredavkina

    2009-12-01

    Full Text Available Patients with systemic lupus erythematosus (SLE form a high risk group osteoporosis (OP. Its main causes are autoimmune inflammation, concomitant pathology, and their treatment. When OP occurs in SLE, bone mass loss is shown to occur early and is associated with the use of glucocorticosteroids (GC. To prevent OP, all patients with SLE should modify their lifestyle. To verify bone changes, densitometry is performed in patients who have risk factors of OP and/or a menopause. Calcium preparations and vitamin D are used to prevent OP; bisphosphonates that significantly reduce the risk of fractures of the vertebral column and femoral neck are employed for therapy of OP. A SLE patient with gluco-corticoid-induced OP and a good effect of bisphophonate treatment is described.

  7. The challenges of lupus anticoagulants.

    Science.gov (United States)

    Chighizola, Cecilia Beatrice; Raschi, Elena; Banzato, Alessandra; Borghi, Maria Orietta; Pengo, Vittorio; Meroni, Pier Luigi

    2016-01-01

    The term "lupus anticoagulant" (LA) refers to a heterogeneous group of immunoglobulins behaving as acquired in vitro inhibitors of coagulation. These antibodies, namely anti-β2GPI and anti-prothrombin antibodies, induce the in vitro elongation of clotting time interfering with phospholipid-dependent coagulation cofactors. Positive LA is associated with thrombosis and pregnancy complications, providing one of the three laboratory criteria for the classification of the anti-phospholipid syndrome. LA is the strongest predictor of clinical events, especially when associated with other anti-phospholipid antibodies. Much more controversial is the risk conveyed by isolated and weak LA. LA detection is technically laborious, envisaging screening, mixing and confirming tests. Hopefully critical issues in LA detection, such as the interference of anticoagulants, will be overcome, in the next future. PMID:26789237

  8. OSTEOPOROSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS

    Directory of Open Access Journals (Sweden)

    N V Seredavkina

    2009-01-01

    Full Text Available Patients with systemic lupus erythematosus (SLE form a high risk group osteoporosis (OP. Its main causes are autoimmune inflammation, concomitant pathology, and their treatment. When OP occurs in SLE, bone mass loss is shown to occur early and is associated with the use of glucocorticosteroids (GC. To prevent OP, all patients with SLE should modify their lifestyle. To verify bone changes, densitometry is performed in patients who have risk factors of OP and/or a menopause. Calcium preparations and vitamin D are used to prevent OP; bisphosphonates that significantly reduce the risk of fractures of the vertebral column and femoral neck are employed for therapy of OP. A SLE patient with gluco-corticoid-induced OP and a good effect of bisphophonate treatment is described.

  9. EL PRIMER APORTE DE LOS OBISPOS CHILENOS A LA CODIFICACIÓN DEL DERECHO CANÓNICO DE 1917: LOS POSTULATA EPISCOPORUM ACERCA DEL MATRIMONIO

    OpenAIRE

    Carlos Salinas Araneda

    2008-01-01

    La redacción del primer Código de Derecho Canónico que tuvo la Iglesia latina fue ordenado por el papa san Pío X, en 1904. La tarea codificadora, empero, no fue obra de un grupo cerrado de expertos, sino que tuvo en cuenta el parecer del episcopado, el que fue consultado en dos momentos diferentes; en ambos casos fueron requeridos los obispos chilenos. En este trabajo se estudia, a partir de la documentación guardada en el Archivo Secreto Vaticano, el aporte de los obispos chilenos en la prim...

  10. ACUTE RESPIRATORY DISEASE AS THE DEBUT OF SYSTEMIC LUPUS ERYTHEMATOSUS

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    A. Yu. Ischenko

    2015-01-01

    Full Text Available Systemic lupus erythematosus — a chronic autoimmune disease that is often associated with infectious processes. The paper presents two clinical cases of systemic lupus erythematosus , debuted with acute respiratory infection.

  11. Proton pump inhibitor-induced subacute cutaneous lupus erythematosus

    DEFF Research Database (Denmark)

    Sandholdt, L H; Laurinaviciene, R; Bygum, Anette

    2014-01-01

    Drug-induced subacute cutaneous lupus erythematosus (SCLE) has been known in the literature since 1985 and is increasingly recognized.......Drug-induced subacute cutaneous lupus erythematosus (SCLE) has been known in the literature since 1985 and is increasingly recognized....

  12. Spontaneous ureteral rupture in a patient with systemic lupus erythematosus

    Energy Technology Data Exchange (ETDEWEB)

    Benson, C.H.; Pennebaker, J.B.; Harisdangkul, V.; Songcharoen, S.

    1983-08-01

    A patient with known systemic lupus erythematosus had fever and symptoms of a lower urinary tract infection. Bone scintigraphy showed left ureteral perforation and necrosis with no demonstrable nephrolithiasis. It is speculated that this episode was due to lupus vasculitis.

  13. Spontaneous ureteral rupture in a patient with systemic lupus erythematosus

    International Nuclear Information System (INIS)

    A patient with known systemic lupus erythematosus had fever and symptoms of a lower urinary tract infection. Bone scintigraphy showed left ureteral perforation and necrosis with no demonstrable nephrolithiasis. It is speculated that this episode was due to lupus vasculitis

  14. Periorbital edema as initial manifestation of chronic cutaneous lupus erythematosus

    OpenAIRE

    Erras, Samar; Benjilali, Laila; Essaadouni, Lamiaa

    2012-01-01

    Periorbital edema occurs frequently in dermatomyositis, but it has rarely been noted in systemic systemic lupus erythematosus. We describe a patient who developed bilateral periorbital edema and erythema as the sole manifestation of systemic lupus erythematosus.

  15. Living Well with Lupus: Can I Still Plan a Pregnancy?

    Science.gov (United States)

    ... of antiphospholipid antibodies Planning Your Pregnancy Although many lupus pregnancies will have no complications, all lupus pregnancies are considered “high risk”—meaning problems may occur ...

  16. For Parents of Children and Teens Living with Lupus

    Science.gov (United States)

    ... Lupus The findings of this study indicate that adolescent girls with lupus scored significantly lower on measures of positive body image and felt increases in negative mood, negative self-esteem, and depressive symptoms. Podcasts | Sep. 11, 2012 Parents ...

  17. Mycophenolate mofetil in the treatment of lupus nephritis

    OpenAIRE

    Patrick FK Yong; David P D’Cruz

    2008-01-01

    Patrick FK Yong1,2, David P D’Cruz21Department of Clinical Immunology, Kings College Hospital; 2The Lupus Research Unit, St Thomas’ Hospital, London, UKAbstract: Lupus nephritis is a complication of systemic lupus erythematosus, which has significant morbidity and mortality. The accepted standard of treatment for severe lupus nephritis is cyclophosphamide for induction of remission. This has significant adverse effects including severe infection and amenorrhea. In addition...

  18. Current and emerging treatment options in the management of lupus

    OpenAIRE

    Jordan, Natasha

    2016-01-01

    Natasha Jordan,1 David D’Cruz2 1Department of Rheumatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, 2Louise Coote Lupus Unit, Guy’s and St Thomas’ Hospital NHS Foundation Trust, London, UK Abstract: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with variable clinical manifestations. While the clearest guidelines for the treatment of SLE exist in the context of lupus nephritis, patients with other lupus manifestations ...

  19. Current and emerging treatment options in the management of lupus

    OpenAIRE

    Jordan N; D’Cruz D

    2016-01-01

    Natasha Jordan,1 David D’Cruz2 1Department of Rheumatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, 2Louise Coote Lupus Unit, Guy’s and St Thomas’ Hospital NHS Foundation Trust, London, UK Abstract: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with variable clinical manifestations. While the clearest guidelines for the treatment of SLE exist in the context of lupus nephritis, patients with other lupus manifestations such as neur...

  20. Prognosis of patients with systemic lupus erythematosus and discoid lesions *

    OpenAIRE

    Skare, Thelma Larocca; Stadler, Bárbara; Weingraber, Emilio; De Paula, Diogo F.

    2013-01-01

    BACKGROUND It has been observed that patients with systemic lupus erythematosus and discoid lesions have a milder systemic disease. OBJECTIVE To compare the clinical, demographic and autoantibody profile of systemic lupus erythematosus patients with and without discoid lesions. METHODS We carried out a retrospective study involving 288 systemic lupus erythematosus patients who met at least four classification criteria of the American College of Rheumatology for systemic lupus erythematosus, c...

  1. CEREBRITIS AND NEUTROPENIA IN A CHILD WITH ANA NEGATIVE LUPUS

    OpenAIRE

    J. Akhoondian; Z. Rezaii yazdi; F Behmanesh; Talebi, S.

    2009-01-01

    ObjectiveSystemic lupus erythematosus (SLE), an autoimmune systemic disease with unknown etiology, affects virtually every part of the body; involvement of the central nervous system (CNS) is one of the major causes of morbidity and mortality in systemic lupus erythematosus (SLE) patients and is the least understood aspect of the disease. neutropenia is very uncommon in childhood lupus. True negative anti nuclear antibody (ANA) tests in patients with lupus are now very rare. The patient repor...

  2. Construcción del cuestionario de “Concepciones sobre inclusión educativa de alumnos con necesidades educativas especiales asociadas a discapacidad intelectual” (CIEDI)

    OpenAIRE

    Constanza San Martín Ulloa; Pilar Fernández Lozano

    2010-01-01

    Las concepciones del profesorado, entendidas como teorías implícitas, constituyen elementos que pueden favorecer u obstaculizar los procesos de inclusión educativa. Con el propósito de explorar y describir las concepciones que docentes y estudiantes chilenos de pedagogía mantienen sobre la inclusión de alumnos que presentan discapacidad intelectual, y debido a la carencia de instrumentos acordes con este objetivo, se construyó un cuestionario de 25 dilemas, organizados en tres dimensiones de ...

  3. ¿Educadores o consumidores? discrepancia del yo, consumo y materialismo en estudiantes chilenos de pedagogía

    OpenAIRE

    Marianela Denegri Coria; Constanza García Jara; Nicolle González Rivera; Jocelyne Sepúlveda Aravena***,

    2014-01-01

    El presente artículo tiene como propósito caracterizar las relaciones existentes entre la discrepancia del Yo, las actitudes hacia la compra y valores materialistas en estudiantes de Pedagogía considerando diferencias de género. Se aplicaron las escalas de Discrepancia del Yo, Actitudes hacia la Compra y Valores Materiales, en una muestra de 167 estudiantes chilenos de las carreras de Pedagogía en Historia de dos universidades del Sur de Chile. Los resultados obtenidos, evidencian correlacion...

  4. Necrotizing and Crescentic Lupus Nephritis with Antineutrophil Cytoplasmic Antibody Seropositivity

    OpenAIRE

    Nasr, Samih H.; D'Agati, Vivette D; Park, Hye-Ran; Sterman, Paul L.; Goyzueta, Juan D.; Dressler, Robert M.; Hazlett, Shawn M.; Pursell, Robert N.; Caputo, Christopher; Markowitz, Glen S.

    2008-01-01

    Background and objectives: Lupus nephritis is a classic immune complex glomerulonephritis. In contrast, antineutrophil cytoplasmic antibodies are associated with necrotizing and crescentic glomerulonephritis, in the absence of significant immune deposits. Antineutrophil cytoplasmic antibodies are detected by indirect immunofluorescence in 20% of patients with systemic lupus erythematosus. We report 10 cases of necrotizing and crescentic lupus nephritis with antineutrophil cytoplasmic antibody...

  5. Dutch guidelines for diagnosis and therapy of proliferative lupus nephritis.

    NARCIS (Netherlands)

    Tellingen, A. van; Voskuyl, A.E.; Vervloet, M.G.; Bijl, M. van der; Sevaux, R.G.L. de; Berger, S.P.; Derksen, R.H.W.M.; Berden, J.H.M.

    2012-01-01

    Proliferative lupus nephritis is a strong predictor of morbidity and mortality in patients with systemic lupus erythematosus. Despite improvements in the management of lupus nephritis, a significant number of the patients do not respond to immunosuppressive therapy and progress to end-stage renal fa

  6. Dutch guidelines for diagnosis and therapy of proliferative lupus nephritis

    NARCIS (Netherlands)

    van Tellingen, A.; Voskuyl, A. E.; Vervloet, M. G.; Bijl, M.; de Sevaux, R. G. L.; Berger, S. P.; Derksen, R. H. W. M.; Berden, J. H. M.

    2012-01-01

    Proliferative lupus nephritis is a strong predictor of morbidity and mortality in patients with systemic lupus erythematosus. Despite improvements in the management of lupus nephritis, a significant number of the patients do not respond to immunosuppressive therapy and progress to end-stage renal fa

  7. Predicción de la masa muscular apendicular esquelética basado en mediciones antropométricas en Adultos Mayores Chilenos

    Directory of Open Access Journals (Sweden)

    Lydia Lera

    2014-03-01

    Full Text Available Objetivos: Desarrollar un modelo antropométrico de predicción de masa muscular apendicular esquelética (MMAE, en adultos mayores chilenos. Métodos: La muestra estudiada corresponde a 616 adultos > 60 años (69,9 ± 5,2 años, 64,6% mujeres, autovalentes, viviendo en la comunidad en Santiago, Chile, participantes del estudio ALEXANDROS. Se efectuaron mediciones antropométricas, dinamometría de mano, pruebas de movilidad y densitometría ósea (DEXA. Mediante modelos de regresión lineal paso a paso se relacionó la MMAE obtenida por DEXA con variables antropométricas, edad y sexo. La muestra se dividió en forma aleatoria en dos submuestras, obteniéndose ecuaciones de predicción para ambas, que se validaron mutuamente por doble validación cruzada. La alta correlación entre los valores de MMAE observados y pronosticados en ambas submuestras y el bajo grado de contracción permitieron desarrollar la ecuación de predicción final con la muestra total. Resultados: El coeficiente de validez cruzada entre las ecuaciones de predicción obtenidas en las dos submuestras fue 0,941 y 0,9409 y el grado de contracción 0,004 y 0,006. La ecuación de predicción final, en la muestra total, fue: MMAE (kg = 0,107(peso kg + 0,251(altura rodilla cm + 0,197(circunferencia pantorrilla cm + 0,047(dinamometría kg - 0,034(circunferencia cadera cm + 3,417(sexo - 0,020 (edad años - 7,646 (R² = 0,89. La MMAE estimada y la medida por DEXA fueron similares (16,8±4,0 vs 16,9±3,7 y concordantes según los métodos de Bland y Altman (IC 95%: -2,6 -2,7 y Lin (coeficiente correlación concordancia = 0,94. Conclusiones: Se obtuvo una ecuación antropométrica para determinar la masa MMEA, de gran utilidad en la pesquisa de sarcopenia en adultos mayores.

  8. Motivação para aprender: o autorrelato de professores brasileiros e chilenos Motivación para aprender: medida del auto-relato de profesores brasileños y chilenos Motivation to learn: measuring the self-report of Brazilian and Chilean teachers

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    Sandra Maieski

    2013-04-01

    Full Text Available Foi objetivo deste estudo verificar a percepção de professores de duas realidades culturais diferentes: Brasil e Chile, quanto às qualidades do comportamento motivado ou desmotivado de seus alunos para aprender. Trata-se de um estudo do tipo descritivo com delineamento de levantamento e tratamento por meio da análise de conteúdo. Participaram 16 professores do ensino fundamental, sendo 7 brasileiros e 9 chilenos. Os dados foram mensurados, mediante de uma entrevista aberta com o professor e categorizados de acordo com os comportamentos motivado e desmotivado apresentados pelos alunos na visão de seus professores. Para tanto, geraram-se dados inerentes ao comportamento motivado e desmotivado apresentado pelos alunos na visão de seus professores. Os dados revelaram muita semelhança na forma como os professores das duas realidades culturais percebem as qualidades relacionadas ao comportamento motivado ou desmotivado de seus alunos. A discussão dos resultados levantados se dá em termos de algumas implicações educacionais.Fue el objetivo de este estudio verificar la percepción de profesores de dos realidades culturales distintas: Brasil y Chile, en cuanto a las cualidades del comportamiento motivado o desmotivado de sus alumnos para aprender. Se trata de un estudio de tipo descriptivo, con delineamiento de levantamiento y tratamiento por medio de análisis de contenido. Participaron 16 profesores de la enseñanza básica, siendo 7 brasileños y 9 chilenos. Los datos fueron medidos por medio de una entrevista abierta con el profesor y categorizados. Para eso, se generaron datos inherentes al comportamiento motivado y desmotivado presentado por los alumnos en la visión de sus profesores. Los datos revelaron mucha semejanza en la forma como los profesores de las dos realidades culturales perciben las cualidades relacionadas al comportamiento motivado o desmotivado de sus alumnos. La discusión de los resultados levantados se da en t

  9. Evolución clínica de pacientes chilenos con tirosinemia tipo I tratados con 2-(2-nitro-4-trifluorometilbenzoil-1,3-ciclohexanediona (NTBC

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    Erna Raimann

    2012-02-01

    Full Text Available Background: Tyrosinemia type I is an inborn error of metabolism due to deficiency of fumarilacetoacetase. Acute presentation is with liver failure, hypophosphatemic rickets and peripheral neuropathy. Chronic presentation is with visceromegaly and subclinical rickets. The most severe complications are hepatic cancer and acute neurological crises. Without treatment, tyrosinemia type 1 is fatal. In 1992 treatment for tyrosinemia type 1 with 2-(2-nitro-4-trifluoromethybenzoyl-1,3-ciclohexanedione (NTBC was proposed. A clinical response was reported in 90% of patients. In cases that did not respond, a successful liver transplantation was performed, reducing mortality to 5%. Aim: To report the follow up of 12 patients treated with NTBC. Patients and Methods: Review of clinical records of 12 Chilean cases treated with NTBC at the Instituto de Nutrición y Tecnología de los Alimentos (INTA from January 2004 until June 2010. Results: In all patients, a rapid metabolic control was achieved. Two patients developed hepatocarcinoma. One of these patients died and one was successfully treated with liver transplantation. One patient died after receiving a liver transplantation. Nine patients have at present good liver function, but 2 had peripheral neuropathy due to late diagnosis and discontinuing NTBC treatment. Conclusions: Treatment with NTBC allows metabolic normalization in tyrosinemia type 1, prevents liver cirrhosis and hepatic cancer, improving survival rates and quality of life in the patients. Neonatal screening is essential for the early diagnosis of this treatable disease, that otherwise may be lethal.

  10. CEREBRITIS AND NEUTROPENIA IN A CHILD WITH ANA NEGATIVE LUPUS

    Directory of Open Access Journals (Sweden)

    J. Akhoondian

    2009-01-01

    Full Text Available ObjectiveSystemic lupus erythematosus (SLE, an autoimmune systemic disease with unknown etiology, affects virtually every part of the body; involvement of the central nervous system (CNS is one of the major causes of morbidity and mortality in systemic lupus erythematosus (SLE patients and is the least understood aspect of the disease. neutropenia is very uncommon in childhood lupus. True negative anti nuclear antibody (ANA tests in patients with lupus are now very rare. The patient reported here was a 12-year-old girl with ANA negative lupus cerebritis who presented with left hemiparesia after a generalized seizure, with neutropenia observed during its course.

  11. Validez predictiva del instrumento de evaluación de riesgos y recursos para la intervención FER-R, en adolescentes chilenos infractores de ley / Predictive Validity at the Instrument Risk and Resources (FER-R for Intervention Assessment with Young Offenders: Preliminary Study

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    Paula Alarcón

    2012-12-01

    Full Text Available Se estudió la validez predictiva del instrumento Ficha de Evaluación de Riesgos y Recursos (FER-R para adolescentes infractores de ley, en un lapso de dos años (2009-2011. La FER-R consta de 60 ítems y permite el registro de 10 dominios, riesgos criminogénicos, recursos y el registro de un índice de escalada delictiva. La muestra estuvo conformada por 101 adolescentes varones, entre 14 y 19 años de edad, judicializados y deriva- dos a programas de intervención en medio libre. Los principales resultados muestran que el índice general de riesgo medido por la FER-R, presenta un 68.3 % de aciertos, con un área bajo la curva ROC = 0.73, indicando una magnitud predictiva fuerte de la escala total para predecir reincidencia en los adolescentes infractores chilenos.

  12. Fatal rhabdomyolysis in systemic lupus erythematosus.

    Science.gov (United States)

    de Carvalho, Jozélio Freire; da Mota, Licia Maria Henrique; Bonfa, Eloisa

    2011-09-01

    The authors describe herein the sixth lupus case that evolved with rhabdomyolysis. A 36-year-old woman with systemic lupus erythematosus was admitted to our hospital with malaise, myalgia, dysphagia, fever, preserved muscle strength, leukocytosis (15,600 cells), and increased creatine kinase of 1,358 IU/L that reached 75,000 IU/L in few days. She denied the use of myotoxic drugs and alcohol. Urine 1 showed false positive for hemoglobinuria (myoglobin) without erythrocytes in the sediment, confirming the diagnosis of rhabdomyolysis. Secondary causes were excluded. She was treated with hyperhydration and alkalinization of urine. Despite treatment, the patient developed pulmonary congestion and she died. The authors also review in this article rhabdomyolysis in patients with systemic lupus erythematosus. PMID:21127876

  13. Mood Disorders in Systemic Lupus Erythematosus

    DEFF Research Database (Denmark)

    Hanly, John G; Su, Li; Urowitz, Murray B;

    2015-01-01

    OBJECTIVE: To examine the frequency, characteristics, and outcome of mood disorders, as well as clinical and autoantibody associations, in a multiethnic/racial, prospective inception cohort of patients with systemic lupus erythematosus (SLE). METHODS: Patients were assessed annually for mood...... disorders (4 types, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) and 18 other neuropsychiatric events. Global disease activity scores (SLE Disease Activity Index 2000 [SLEDAI-2K]), damage scores (Systemic Lupus International Collaborating Clinics/American College...... risk was associated with Asian race/ethnicity (P = 0.01) and treatment with immunosuppressive drugs (P = 0.003). Mood disorders were associated with lower mental health and mental component summary scores but not with the SLEDAI-2K, SDI, or lupus autoantibodies. Among the 232 patients with depression...

  14. Psychosis in Patients with Systemic Lupus Erythematosus

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    Raghavendra B Nayak

    2012-01-01

    Full Text Available Neuropsychiatric manifestations in systemic lupus erythematosus (SLE are common; however, psychosis per se is bit uncommon. They may be cognitive deficit, lupus headache, psychoses, seizures, peripheral neuropathy, and cerebrovascular events. Psychiatric symptoms in SLE can be functionally independent psychiatric disorders. It can be due to drugs (steroids used for SLE or secondary to SLE because of its brain involvement, which is termed as neuropsychiatric systemic lupus erythematosus (NPSLE. No single clinical, laboratory, neuropsychological, and imaging test can be used to differentiate NPSLE from non-NPSLE patients with similar neuropsychiatric manifestations. Presently we are discussing about three cases of SLE with psychosis and which had different clinical presentation. The present reports also depict the approach to case differential diagnosis and management of the same.

  15. The Clinicopathological Study of Lupus Nephritis

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    Raouf Rahim Merza

    2014-08-01

    Results: The current study shows female predominance 32(71.1% compared with 13(28.9% male. Class IV 15(33.3% nephritis was the most common type followed by class III 9(20.9%.The male patients develop nephritis early in the course of Systemic lupus erythematosis than females, and they were more commonly had hypertension and edema, and the hematological, cardiovascular, pulmonary, and central nervous system were the most common extra renal manifestation in males while mucocutaneous manifestations were the commonest in females, and further more males had more proliferative type of Lupus nephritis than females. Conclusion: Males had more severe type of lupus nephritis than females. [Cukurova Med J 2014; 39(4.000: 679-688

  16. Urinary CXCL10: a marker of nephritis in lupus patients

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    M. A. Marie

    2014-03-01

    Full Text Available Systemic lupus erythematosus (SLE is a connective tissue disease characterized by the formation of autoantibodies and immune complexes. Lupus nephritis is one of the hallmark features of SLE. CXCL10 is a chemokine secreted by IFNg- stimulated endothelial cells and has been shown to be involved in the pathological processes of autoimmune diseases. The objective was to measure urinary CXCL10 in SLE patients, to compare levels between nephritis and non-nephritis groups and to study its correlation with other variables. Sixty lupus patients were enrolled in our trial. Thirty patients had lupus nephritis and the other 30 were without evidence of lupus nephritis. Thirty healthy subjects were willing to participate as a healthy control group. Renal biopsy was performed for lupus nephritis group. Urinary CXCL10 was measured using the ELISA technique. Serum creatinine, C3, C4 and 24 h urinary proteins were measured. Lupus activity was assessed using systemic lupus erythematosus disease activity index (SLEDAI scoring system. Renal activity was measured using renal activity scoring system. CXCL10 was significantly higher in lupus nephritis patients than in lupus patients without nephritis. CXCL10 was significantly correlated with renal activity score, 24 hours urinary proteins and the SLEDAI score. It is highly valid predictor of SLE nephritis with high sensitivity and specificity. CXCL 10 a highly sensitive and specific non-invasive diagnostic tool for lupus nephritis patients.

  17. Estado nutricional en escolares chilenos según la referencia NCHS y OMS 2007 Nutritional status in Chilean school children according to NCHS and WHO 2007 reference

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    E. Atalah Samur

    2012-02-01

    Full Text Available Antecedentes: El 2007 la OMS publicó una nueva referencia para evaluar el estado nutricional en niños y adolescentes de 5 a 19 años, que incluye tablas de índice de masa corporal (IMC por edad y sexo. Objetivo: Análisis comparativo del estado nutricional según IMC en escolares y adolescentes chilenos utilizando la norma vigente del Ministerio de Salud (NCHS y la nueva referencia OMS 2007. Material y métodos: Cohorte retrospectiva de 117.745 recién nacidos, con evaluación nutricional al ingresar a educación básica (1997 y enseñanza media (2005. Se analizó el estado nutricional según IMC en relación a las referencias NCHS 1977, OMS 2007 en desviaciones estándar (DE y en percentiles. Se evaluó la concordancia diagnóstica según los tres criterios con el índice Kappa. Resultados: Hubo pocas diferencias en la clasificación nutricional en primero básico (6,4 ± 0,3 años entre los tres criterios. En primero medio (14,4 ± 0,3 años fue mayor la prevalencia de bajo peso con ambas referencias OMS, de sobrepeso con OMS DE y de obesidad con OMS percentiles (p Background: In 2007, WHO published a new reference for assessing the nutritional status of children and adolescents aged 5 to 19 years, including body mass index (BMI by sex and age. Objective: To compare the nutritional assessment by BMI in schoolchildren and adolescents using the actual Chilean Ministry of Health norm (NCHS and the new WHO reference 2007. Material and methods: Retrospective cohort study of 117,745 newborns, with nutritional assessment on first year of basic education (1997 and later in high education (2005. We analyzed the nutritional status according to BMI for age in relation to the NCHS references and WHO 2007, in standard deviations (SD and percentiles. We analyzed the agreement between the different references with the Kappa index. Results: There were small differences in the nutritional classification in first grade (6,4 ± 0,3 years between the three

  18. CEREBRITIS AND NEUTROPENIA IN A CHILD WITH ANA NEGATIVE LUPUS

    Directory of Open Access Journals (Sweden)

    J. Akhoondian

    2009-04-01

    Full Text Available ObjectiveSystemic lupus erythematosus (SLE, an autoimmune systemic disease with unknown etiology, affects virtually every part of the body; involvement of the central nervous system (CNS is one of the major causes of morbidity and mortality in systemic lupus erythematosus (SLE patients and is the least understood aspect of the disease. neutropenia is very uncommon in childhood lupus. True negative anti nuclear antibody (ANA tests in patients with lupus are now very rare. The patient reported here was a 12-year-old girl with ANA negative lupus cerebritis who presented with left hemiparesia after a generalized seizure, with neutropenia observed during its course.Key words:lupus cerebritis, neutropenia, ANA negative lupus, children

  19. Bullous Systemic Lupus Erythematosus: Case report

    OpenAIRE

    Miziara, Ivan Dieb; Mahmoud, Ali; Chagury, Azis Arruda; Alves, Ricardo Dourado

    2013-01-01

    Summary Introduction: Bullous systemic lupus erythematosus (BSLE) is an autoantibody-mediated disease with subepidermal blisters. It is a rare form of presentation of SLE that occurs in less than 5% of cases of lupus. Case Report: A 27-year-old, female, FRS patient reported the appearance of painful bullous lesions in the left nasal wing and left buccal mucosa that displayed sudden and rapid growth. She sought advice from emergency dermatology staff 15 days after onset and was hospitalized wi...

  20. Ofatumumab treatment in lupus nephritis patients.

    Science.gov (United States)

    Haarhaus, Malena Loberg; Svenungsson, Elisabet; Gunnarsson, Iva

    2016-08-01

    Rituximab is frequently used in systemic lupus erythematosus; however, side effects such as infusion-related reactions limit its use. In this case report, we describe, for the first time, treatment with ofatumumab in four patients with lupus nephritis. The treatment was well tolerated in three of the patients, and a reduction of proteinuria was seen in all cases. This emphasizes the importance of alternative B-cell-depleting therapies in patients with an initial good response to rituximab, but who develop side effects. PMID:27478595

  1. Evaluación psicométrica de la escala de conducta delictiva y violenta en el aula, en estudiantes chilenos (Psychometric Assessment Of The Criminal And Violent Behavior Scale In The Classroom, In Chilean Students

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    Daniela Vera-Bachmann

    2014-12-01

    Full Text Available RESUMEN: Se reporta evidencia empírica sobre las propiedades psicométricas de la Escala de conducta delictiva y violenta en el aula, en una muestra de 877 estudiantes secundarios chilenos, cuyas edades están comprendidas entre los 13 y los 20 años (M = 15.94, DT = 1.31. Los análisis factoriales exploratorios y confirmatorios han aportado evidencia de validez cruzada, corroborando la estructura original de dos factores; factor conducta violenta disruptiva y factor victimización. Las medidas de consistencia interna y homogeneidad fueron satisfactorias para ambas subescalas, así como su correlación con medidas de clima social escolar. Se concluye que esta escala brinda garantías de confiabilidad y validez para su uso en Chile. ABSTRACT: Empirical evidence is reported on the psychometric properties of the Scale of criminal and violent behaviorin the classroom, in a sample of 877 Chilean high school students, between the ages of 13 and 20 (M = 15.94, DT = 1.31 . Exploratory and confirmatory factor analysis have provided evidence of cross validity, corroborating the original two factor structure; the violent behavior disruptive factor and the victimization factor. Measures of internal consistency and uniformity were satisfactory for both subscales, as well as their correlation with school social climate measures. It is concluded that this scale provides guarantee of reliability and validity for its use in Chile.

  2. Francia y Alemania: Génesis, Desarrollo y Cese de la hostilidad franco-alemana. Un análisis comparativo para el caso chileno-peruano Parte I

    Directory of Open Access Journals (Sweden)

    Cristián Leyton Salas

    2005-12-01

    Full Text Available El presente artículo es la primera parte de un estudio del autor que compara la relación chileno-peruana con la relación franco-alemana, la cual, antes de la segunda guerra mundial, se construía sobre la base de la desconfianza mutua producto de la imagen negativa del otro formada a través de la historia común. En esta primera parte del artículo, el autor realiza un análisis de los orígenes de la conflictividad franco-alemana, que desembocará en la creación de la idea del “enemigo hereditario” o “encarnación del mal”, y que producirá los mayores enfrentamientos entre ambas naciones, desde la guerra franco-prusiana hasta la segunda guerra mundial, concluyendo que esta historia de continuos desencuentros y conflictos fue el detonante del histórico enfrentamiento entre alemanes y franceses.

  3. Successful treatment of massive ascites due to lupus peritonitis with hydroxychloroquine in old- onset lupus erythematosus

    OpenAIRE

    Hammami, Sonia; Bdioui, Fethia; Ouaz, Afef; Loghmari, Hichem; Mahjoub, Sylvia; Saffar, Hamouda

    2014-01-01

    Systemic lupus erythematous (SLE) is an auto-immune disease with multiple organ involvements that occurs mainly in young women. Literature data suggest that serositis is more frequent in late-onset SLE. However, peritoneal serositis with massive ascites is an extremely rare manifestation. We report a case of old-onset lupus peritonitis treated successfully by Hydroxychloroquine. A 77-year-old Tunisian woman was hospitalized because of massive painful ascites. Her family history did not includ...

  4. Dengue fever triggering systemic lupus erythematosus and lupus nephritis: a case report

    OpenAIRE

    Talib SH; Bhattu SR; Bhattu R; Deshpande SG; Dahiphale DB

    2013-01-01

    SH Talib, SR Bhattu, R Bhattu, SG Deshpande, DB Dahiphale Department of Medicine and Nephrology, MGM Medical College and Hospital, Aurangabad, Maharashtra, India Abstract: We report a rare case of dengue fever triggering systemic lupus erythematosus and lupus nephritis. The patient presented herself during a large outbreak of dengue fever in December 2012 in Maharashtra, India. The diagnosis of dengue fever was confirmed by the presence of NS-1 antigen during the first few days of febrile il...

  5. Immunological aspects of biopsy-proven lupus nephritis in Bahraini patients with systemic lupus erythematosus

    OpenAIRE

    Eman M Farid; Hassan, Adla B; Ali A Abalkhail; Amgad E El-Agroudy; Sameer Al-M Arrayed; Sumaya M Al-Ghareeb

    2013-01-01

    Lupus nephritis (LN) is a frequent and potentially serious complication of systemic lupus erythematosus (SLE) that may influence morbidity and mortality. Immunological investigations are aiding tools to the kidney biopsy findings in early diagnosis, in addition to monitoring the effect of therapy. The aim of the present study is to highlight the role of these investigations in a group of Bahraini patients and to determine whether there is any positive association between these findings and th...

  6. Lupus podocytopathy: An important differential diagnosis of nephrotic syndrome in systemic lupus erythematosus.

    Science.gov (United States)

    Chaudhury, A R; Rajarajan, T; Yousuf, R; Fernando, E; Kurien, A A

    2016-01-01

    Some patients with systemic lupus erythematosus (SLE) present with sudden onset of nephrotic syndrome and biopsy findings may be of minimal change disease or focal segmental glomerulosclerosis with diffuse foot process effacement on electron microscopy but without significant immune deposits. This entity is termed lupus podocytopathy. Clinicians and renal pathologists need to be aware of this condition. Though steroid sensitive, it needs follow-up to recognize flare and class change, thereby optimizing therapy. PMID:27512302

  7. Composición fibrilar y densidad capilar del músculo Gluteus medius del caballo criollo chileno en reposo Fibre composition and capillary supply of the Gluteus medius muscle in resting Chilean criollo horses

    Directory of Open Access Journals (Sweden)

    R. PEREZ

    1997-01-01

    Full Text Available Se realizó un estudio con el objetivo de analizar la composición fibrilar y la densidad capilar del músculo Gluteus medius del equino fina sangre chileno en reposo. Para el estudio se muestrearon 6 caballos chilenos adultos (5-10 años, durante el período de descanso previo al inicio de la temporada de rodeo. Biopsias musculares fueron extraídas desde una profundidad estándar de 6 cm. Mediante la técnica de la miosina ATPasa miofibrilar se determinó la distribución de los distintos tipos de fibras musculares, las que según sus patrones de reacción fueron clasificadas en los tipos I, IIA y IIB. Además, la densidad capilar se determinó mediante la técnica de alfa amilasa PAS. Los resultados muestran una mayor proporción de fibras de contracción rápida tipo II, dentro de ellas las tipo IIB son más frecuentes (42.5% que las tipo IIA (39.0%. Esta distribución en la composición fibrilar significaría que el músculo G. medius del caballo chileno está mejor adaptado para realizar trabajo de velocidad y resistencia. La mayor frecuencia de fibras tipo IIB y una baja densidad capilar (253 ± 26 capilares/mm2 permiten pensar que estas características están asociadas a una falta de aptitud física producto de un reposo prolongadoA study to analyze fibre composition and capillary supply of the Gluteus medius muscle of the Chilean criollo horse under resting conditions was carried out. Six adult (5-10 year old, clinically healthy Chilean criollo horses were sampled through a muscle biopsy technique during the period previous to the rodeo competition. Muscular biopsies were obtained from the left Gluteus medius at 6 cm of depth below the fascia. Muscle samples were serially sectioned and stained for myofibrilar ATP-ase and amylase-PAS, in order to identify types I, IIA and IIB fibres and to evaluate the fibre type distribution, the cross sectional area and capillary density. The results showed that the Chilean criollo horse has a greater

  8. The need for a hydromorphological approach to Chilean river management La necesidad de un enfoque hidromorfológico para la gestión de los ríos chilenos

    Directory of Open Access Journals (Sweden)

    ANDREA ANDREOLI

    2012-09-01

    considerar al determinar el estado ecológico de los ríos. La comprensión de cómo las variables hidrológicas y morfológicas interactúan de forma dinámica es sin duda clave para evaluar la presencia o ausencia de un equilibrio dinámico, una condición que, a su vez, fomenta tanto la diversidad de hábitat como el desarrollo sostenible de los ecosistemas acuáticos y ribereños. Los autores concluyen que es necesario cambiar el paradigma actual de gestión aplicado en los ríos chilenos desarrollando una estrategia que permita evaluar las condiciones hidromorfológicas y ecológicas de los ríos. Además, sugieren implementar legislación específica orientada a promover estándares ecológicos y geomorfológicos en la práctica de gestión, con el apoyo de un fortalecimiento y una ampliación de la enseñanza académica de la geomorfología y ecología fluvial.

  9. Patologías dentales en incisivos, caninos y primer premolar en caballos chilenos adultos Dental pathologies in incisors, canines and first premolar in adult Chilean horses

    Directory of Open Access Journals (Sweden)

    L Muñoz

    2010-01-01

    Full Text Available Las patologías dentales han ido tomando mayor relevancia clínico veterinaria, aumentando el número de consultas, tratamientos y procedimientos preventivos. En caballos chilenos, la información existente de patologías dentales es nula, por lo que se hace primordial la investigación y recolección de datos en esta raza. Se analizaron 100 caballos pertenecientes a la Asociación de Rodeo Concepción, entre los meses de junio y septiembre del año 2007. Los materiales que se utilizaron fueron puro, linterna, sonda odontológica y espejo odontológico. El examen incluyó reseña, anamnesis y examen dental, registrando todo lo encontrado en una ficha odontológica. Ochenta y ocho ejemplares presentaron algún tipo de patología dental (88%. Las patologías más frecuentes fueron fracturas con 46%, tártaro con 33% y braquignatia con 32%, todos estos ubicados en los incisivos (’01-‘03. Sesenta y siete caballos (55 machos y 22 hembras poseían uno o más caninos (77%. De éstos, 38 (49,35% presentaba patologías en caninos, siendo lo más frecuente caninos ciegos (24,67%. Se encontraron 16 equinos (13 machos y 3 hembras con uno o más primeros premolares (diente de lobo (16%, ninguno mandibular. Sólo se encontró un caso de patología en un primer premolar que correspondió a enfermedad periodontal. Se encontraron diferencias estadísticas asociadas al sexo, para boca en declive en incisivos y caninos ciegos.Dental pathologies have reached a higher veterinary clinical relevance, increasing the number of consultations, treatments and preventive proceedings. In Chilean horses, the information of dental pathologies is inexistent making the research and the data collection in this breed interesting. One hundred horses that came from the Asociación de Rodeo de Concepción, were analyzed between June and September 2007. The materials used were nosetwitch, flashlight, dental probe and intra-oral mirror. The visit started with an interview, followed

  10. Symptoms, Causes, Diagnosis, and Treatment of Lupus | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... this page please turn JavaScript on. Feature: Lupus Causes, Diagnosis, and Treatment of Lupus Past Issues / Spring ... system is affected varies from person to person. Causes Lupus is a complex disease, and its cause ...

  11. Progress Made in Lupus Diagnosis and Treatment | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... of this page please turn JavaScript on. Feature: Lupus Progress Made in Lupus Diagnosis and Treatment Past Issues / Spring 2014 Table ... W. Clark NIAMS For our readers who have lupus or are the loved ones of someone with ...

  12. Lupus: When the Body Attacks Itself | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... of this page please turn JavaScript on. Feature: Lupus Lupus: When the Body Attacks Itself Past Issues / Spring 2014 Table of Contents fast facts 1 Lupus occurs when the body's immune system attacks the ...

  13. Estrategias de intensificación y de atenuación en la conversación coloquial de jóvenes chilenos

    Directory of Open Access Journals (Sweden)

    Lésmer Antonio Montecino S.

    2004-12-01

    Full Text Available Este estudio pretende, desde una perspectiva pragmática y crítica, mostrar, por una parte, cómo un grupo de hablantes chilenos utiliza estas estrategias discursivas para argumentar, cuestionar y emitir juicios de valor que comprometen su sistema de creencias respecto de la institución y de los grupos a los que están afiliados y, por otra, discutir sus efectos, considerando que todo acto de habla implica una amenaza y que, en consecuencia, se constituye en un acto de poder. Los intensificadores y los atenuadores son recursos discursivos que, en la conversación coloquial, se vinculan al concepto de fuerza argumentativa y configuran estrategias para que el YO refuerce y haga valer su intención de habla en forma cooperativa y cortés o, en ocasiones, mitigue lo expresado con el fin de mantener el equilibrio de la interacción. Para sustentar empíricamente el estudio, utilizo el corpus de interacciones verbales entre jóvenes universitarios, recolectado para la realización del proyecto núcleo "La interacción verbal de estudiantes universitarios de Chile y de Argentina" del programa "El español de Chile y de Argentina" (ECLAR, que reúne a académicos de la Pontificia Universidad Católica de Chile y de la Universidad Nacional de La Plata, Argentina. (This study shows, from a pragmatic and critical perspective, how a group of Chilean speakers use discourse strategies to argue, question and emit value judgments that compromise their belief systems with respect to the institutionand to the groups with which they are affiliated. It also discusses its effects, considering that all speech acts imply a threat and that, consequently, constitute in themselves an act of empowering. Intensifiers and mitigating markers are discourse resources that in colloquial conversation are linked to the concept of argumentative force and they form strategies in which ‘I’ is reinforced and expresses communicative intention in a cooperative and courteous way

  14. Lupus Vulgaris At A Rare Site

    Directory of Open Access Journals (Sweden)

    Bhaduri Gautam

    1999-01-01

    Full Text Available A case of lupus vulgaris at a rare site-eyelid is reported here. Delayed diagnosis of the condition affecting the left eyelid in a female patient aged 78 years, led to scarring and fixity of eyelids with resultant exposure keratitis and dimness of vision. Antitubercular therapy improved skin condition but dimness f vision persisted.

  15. Epigenetics and Systemic Lupus Erythematosus: Unmet Needs.

    Science.gov (United States)

    Meroni, Pier Luigi; Penatti, Alessandra Emiliana

    2016-06-01

    Systemic lupus erythematosus (SLE) is a chronic relapsing-remitting autoimmune disease affecting several organs. Although the management of lupus patients has improved in the last years, several aspects still remain challenging. More sensitive and specific biomarkers for an early diagnosis as well as for monitoring disease activity and tissue damage are needed. Genome-wide association and gene mapping studies have supported the genetic background for SLE susceptibility. However, the relatively modest risk association and the studies in twins have suggested a role for environmental and epigenetic factors, as well as genetic-epigenetic interaction. Accordingly, there is evidence that differences in DNA methylation, histone modifications, and miRNA profiling can be found in lupus patients versus normal subjects. Moreover, impaired DNA methylation on the inactive X-chromosome was suggested to explain, at least in part, the female prevalence of the disease. Epigenetic markers may be help in fulfilling the unmet needs for SLE by offering new diagnostic tools, new biomarkers for monitoring disease activity, or to better characterize patients with a silent clinical disease but with an active serology. Anti-DNA, anti-phospholipid, and anti-Ro/SSA autoantibodies are thought to be pathogenic for glomerulonephritis, recurrent thrombosis and miscarriages, and neonatal lupus, respectively. However, tissue damage occurs occasionally or, in some patients, only in spite of the persistent presence of the antibodies. Preliminary studies suggest that epigenetic mechanisms may explain why the damage takes place in some patients only or at a given time. PMID:26206675

  16. Hypocomplementemic Urticarial Vasculitis in Systemic Lupus Erythematosus

    OpenAIRE

    Her, Min Young; Song, Joo Yeon; Kim, Dong Yook

    2009-01-01

    Urticarial vasculitis is characterized clinically by urticarial skin lesions and histologically by leukocytoclastic vasculitis. Hypocomplementemic urticarial vasculitis is associated with connective tissue diseases such as systemic lupus erythematosus (SLE). We report a case of urticarial vasculitis that preceded manifestations of SLE.

  17. Genetics of T Cell Defects in Lupus

    Institute of Scientific and Technical Information of China (English)

    Yifang Chen; Laurence More

    2005-01-01

    Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by anti-nuclear autoantibodies that cause damage to multiple organs and tissues. Intrinsic defects have been demonstrated in the lymphoid and myeloid cellular compartments, including T cells. Lupus susceptibility is mediated through the interplay of a large number of genes, most of which are still unidentified. Most of the genetic studies in both human patients and mouse models have addressed lupus susceptibility as a whole. More recently however, more attention has been paid to the inheritance of specific lupus-associated phenotypes. In this review, we summarized our results obtained with the Slel locus in the NZM2410 mouse model, which mediates the generation of anti-histone autoreactive T cells. Sle1,which is constituted of multiple genes, is the only known genomic region that is sufficient for the generation of autoreactive T cells. The identification of the corresponding genes will constitute a landmark for our understanding of the mechanisms of autoimmunity. Our results are discussed in the context of candidate genes and the role of T cells in systemic autoimmunity.

  18. The frequency and outcome of lupus nephritis

    DEFF Research Database (Denmark)

    Hanly, John G; O'Keeffe, Aidan G; Su, Li;

    2016-01-01

    OBJECTIVE: To determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort. METHODS: Patients in the Systemic Lupus International Collaborating Clinics inception cohort (≤15 months of SLE diagnosis) were assessed annually for estimated glomerular filtration rate (e...

  19. Autoinoculation lupus vulgaris of the perineum.

    OpenAIRE

    Sehgal, V N; Chaudhry, A K; Gupta, R.

    1991-01-01

    The case of a young heterosexual male, with a 7 year history of an asymptomatic progressive plaque over the right side of the perineum is described, which 4 years later involved the left perineum and scrotal skin, indicating autoinoculation. The diagnosis of lupus vulgaris was made by strongly positive tuberculin test, histopathology, and a favourable response to a short course of intensive antitubercular therapy.

  20. Rhino Cerebral Mucormycosis in Systemic Lupus Erythematosus

    OpenAIRE

    Parimalam Kumar; C Zohra Begum; Thirumaran, P; Manoharan, K

    2013-01-01

    Systemic lupus erythematosus (SLE) is a multisystem connective tissue disease. Patients with SLE develop cutaneous infections due to immune dysregulation and treatment with immunosuppressive agents. Deep fungal infections are rare in SLE but are important cause of morbidity. We report a case of successfully treated rhino cerebral mucormycosis (RCM) in a female patient with SLE.

  1. Update on systemic lupus erythematosus pregnancy

    OpenAIRE

    Iozza, Irene; Cianci, Stefano; Di Natale, Angela; Garofalo, Giovanna; Giacobbe, Anna Maria; Giorgio, Elsa; De Oronzo, Maria Antonietta; Politi, Salvatore

    2010-01-01

    Women with Systemic Lupus Erythematosus (SLE) still face significant risks when embarking on a pregnancy. Improvements in the field of pathophysiology, in diagnosis and a greater number of therapeutic options in the treatment of SLE, have made the medical community regard these patients with less trepidation. Despite these advances, however, the risk of significant morbidity to both the mother and the fetus still exists.

  2. Lupus eritematoso sistémico síndrome de cushing y psiquiatría

    OpenAIRE

    Pájaro Silva, Ludwig

    2014-01-01

    Se presenta el caso de una paciente con diagnósticode lupus eritematoso sistémico y síndromede Cushing quien presentó síntomas afectivosde características depresivas e insomnio de conciliación,quien recibió múltiples tratamientosfarmacológicos con pobre respuesta inicial. Lapsiquiatría de enlace consolida una alternativade tratamiento multidisciplinario para una aproximaciónmás eficiente a las patologías médicascon síntomas psiquiátricos.

  3. Hemorrhagic cholecystitis and hemobilia: two infrequent complications of systemic lupus erythematosus Colecistitis hemorrágica y hemofilia: dos complicaciones infrecuentes del lupus eritematoso sistémico

    Directory of Open Access Journals (Sweden)

    Rocío García Pérez

    2011-08-01

    Full Text Available Introduction: the patients affected by systemic lupus erythematosus (SLE often suffer gastrointestinal symptoms. The differential diagnosis should contemplate pathology of the gall bladder. We present the case of a patient with hemorrhagic lithiasic cholecystitis and hemobilia. Case report: 24 year old female diagnosed with SLE under treatment with Sintrom®, Dacortin® and Dolquine® that presented acute lithiasic cholecystitis and hemobilia with a distal calculus. Cholecystectomy and aperture of the ductus choledochus were performed allowing to confirm the hemobilia and to extract the calculus. Discussion: the treatment of cholecystitis in the patients with SLE is controversial due to the fact that most reviewed cases have been solved with cholecystectomy, or in other cases with conservative treatment with corticosteroids. We believe that the presence of cholelithiasis in a patient with SLE with pain on the right hypochondrium and ultrasound confirming the suspicion of cholecystitis demands a surgical treatment since the cause may be vascular, lithiasic or combined. Besides, the possible complications will not respond to pharmaceutical treatment.Introducción: los pacientes afectos de lupus eritematoso sistémico (LES sufren con frecuencia síntomas gastrointestinales. Debe incluirse en su diagnóstico diferencial la patología de la vesícula biliar. Presentamos el caso de una paciente con colecistitis alitiásica y hemobilia. Caso clínico: mujer de 24 años diagnosticada de LES en tratamiento con Sintrom®, Dacortin® y Dolquine® que presentó cuadro de colecisititis aguda litiásica y hemobilia, con presencia de cálculo enclavado en papila. Se realizó colecistectomía y apertu-ra del colédoco, lo que permitió confirmar la hemobilia y extracción del cálculo. Discusión: el tratamiento de la colecistitis en los pacientes con LES es controvertido ya que, aunque la mayoría de los casos revisados se han resuelto con la colecistectom

  4. Clinical and immunopathological features of patients with lupus hepatitis

    Institute of Scientific and Technical Information of China (English)

    ZHENG Ru-hua; WANG Jin-hui; WANG Shu-bing; CHEN Jie; GUAN Wei-ming; CHEN Min-hu

    2013-01-01

    Background Lupus hepatitis is yet to be characterized based on its clinical features and is often difficult to differentially diagnose from other liver diseases.We aimed to elucidate clinical,histopathological and immunopathological features of lupus hepatitis and to evaluate primarily the effectiveness of liver immunopathological manifestations on differential diagnosis of lupus hepatitis from other liver diseases.Methods A retrospective study was performed to analyze clinical features of lupus hepatitis in 47 patients out of 504 inpatients with systemic lupus erythematosus (SLE) in First Affiliated Hospital of Sun Yat-sen University,China from May 2006 to July 2009,and to evaluate the association between lupus hepatitis and SLE activity.Additionally,liver histopathological changes by hematoxylin and eosin (HE) staining and immunopathological changes by direct immunofluorescence test in 10 lupus hepatitis cases were analyzed and compared to those in 16 patients with other liver diseases in a prospective study.Results Of 504 SLE patients,47 patients (9.3%) were diagnosed to have lupus hepatitis.The prevalence of lupus hepatitis in patients with active SLE was higher than that in those with inactive SLE (11.8% vs.3.2%,P <0.05).The incidence of hematological abnormalities in patients with lupus hepatitis was higher than that in those without lupus hepatitis (40.4% vs.21.7%,P <0.05),such as leucocytes count (2.92×109/L vs.5.48×109/L),platelets count (151×109/L vs.190×109/L),serum C3 and C4 (0.34 g/L vs.0.53 g/L; 0.06 g/L vs.0.09 g/L) (P <0.05); 45 of 47 (95.7%) lupus hepatitis patients showed 1 upper limit of normal (ULN) <serum ALT level <5 ULN.The liver histopathological features in patients with lupus hepatitis were miscellaneous and non-specific,similar to those in other liver diseases,but liver immunopathological features showed positive intense deposits of complement 1q in 7/10 patients with lupus hepatitis and negative complement 1q

  5. Association of Sweet's Syndrome and Systemic Lupus Erythematosus

    OpenAIRE

    Fye, K. H.; M. Dall'Era; Gensler, L.; McCalmont, T. H.; Yazdany, J.; Barton, J. L.; Richman, N; Pincus, L

    2011-01-01

    Sweet's syndrome is an acute febrile neutrophilic dermatosis which usually presents as an idiopathic disorder but can also be drug induced, associated with hematopoetic malignancies and myelodysplastic disorders, and more, infrequently, observed in autoimmune disorders. Sweet's syndrome has been reported in three cases of neonatal lupus, three cases of hydralazine-induced lupus in adults, and in nine pediatric and adult systemic lupus erythematosus (SLE) patients. We describe three additional...

  6. The Pathogenesis of Systemic Lupus Erythematosus – An Update

    OpenAIRE

    Choi, Jinyoung; Kim, Sang Taek; Craft, Joe

    2012-01-01

    Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific t...

  7. The United States to Africa lupus prevalence gradient revisited

    OpenAIRE

    Gilkeson, GS; James, JA; Kamen, DL; Knackstedt, TJ; Maggi, DR; Meyer, AK; Ruth, NM

    2011-01-01

    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that has a significantly higher prevalence, morbidity and mortality in African Americans compared with Americans of European descent. The pathogenesis of lupus is unclear but appears to be a result of environmental factors interacting with a genetically susceptible host. Despite the high disease load of SLE in African Americans, there is the perception that lupus is relatively rare in Africa. This prevalence gradient suggests...

  8. T Tauri Disk Lifetime in the Lupus Association

    Science.gov (United States)

    Galli, P. A. B.; Bertout, C.; Teixeira, R.; Ducourant, C.

    2016-01-01

    In a recent study, we derived individual distances for a sample of pre-main sequence stars that define the comoving association of young stars in the Lupus star-forming region. Here, we use these new distances to investigate the mass and age distributions of Lupus T Tauri stars and derive the average disk lifetime in the Lupus association based on an empirical disk model.

  9. Autologous Fat Transfer in a Patient with Lupus Erythematosus Profundus

    Directory of Open Access Journals (Sweden)

    Jimi Yoon

    2012-10-01

    Full Text Available Lupus erythematosus profundus, a form of chronic cutaneous lupus erythematosus, is a rare inflammatory disease involving in the lower dermis and subcutaneous tissues. It primarily affects the head, proximal upper arms, trunk, thighs, and presents as firm nodules, 1 to 3 cm in diameter. The overlying skin often becomes attached to the subcutaneous nodules and is drawn inward to produce deep, saucerized depressions. We present a rare case of lupus erythematosus profundus treated with autologous fat transfer.

  10. Lupus Nephritis: The Evolving Role of Novel Therapeutics

    OpenAIRE

    Rovin, Brad H; Parikh, Samir V

    2014-01-01

    Immune complex accumulation in the kidney is the hallmark of lupus nephritis and triggers a series of events that result in kidney inflammation and injury. Cytotoxic agents and corticosteroids are standard of care for lupus nephritis treatment, but are associated with considerable morbidity and suboptimal outcomes. Recently, there has been interest in using novel biologic agents and small molecules to treat lupus nephritis. These therapies can be broadly categorized as anti-inflammatory (laqu...

  11. Intravenous Immunoglobulin in the Management of Lupus Nephritis

    OpenAIRE

    Wenderfer, Scott E.; Trisha Thacker

    2012-01-01

    The occurrence of nephritis in patients with systemic lupus erythematosus is associated with increased morbidity and mortality. The pathogenesis of lupus nephritis is complex, involving innate and adaptive cellular and humoral immune responses. Autoantibodies in particular have been shown to be critical in the initiation and progression of renal injury, via interactions with both Fc-receptors and complement. One approach in the management of patients with lupus nephritis has been the use of i...

  12. Two Case Reports Indicating the Dilemma in Diagnosing Lupus Cerebritis

    OpenAIRE

    Goswami, Dharitri; Chatterjee, Shuddhosatta; Ahmad, Bashar Imam; Das, Shantanu

    2013-01-01

    Systemic Lupus Erythematosus (SLE) is a connective-tissue disorder commonly affecting females of reproductive age group. Lupus Cerebritis is a serious neurological complication encountered in a good percentage of SLE cases. In this report, we discuss two Lupus Cerebritis patients, who were successfully diagnosed and treated. The first case, presented with generalized seizure, severe metabolic acidosis, and shock, with a history of fever of one-month duration. The second case manifested with a...

  13. The Chilean Health System: 20 Years of Reforms El sistema de salud chileno: 20 años de reformas

    Directory of Open Access Journals (Sweden)

    Annick Manuel

    2002-01-01

    Full Text Available The Chilean health care system has been intensively reformed in the past 20 years. Reforms under the Pinochet government (1973-1990 aimed mainly at the decentralization of the system and the development of a private sector. Decentralization involved both a deconcentration process and the devolution of primary health care to municipalities. The democratic governments after 1990 chose to preserve the core organization but introduced reforms intended to correct the system's failures and to increase both efficiency and equity. The present article briefly explains the current organization of the Chilean health care system. It also reviews the different reforms introduced in the past 20 years, from the Pinochet regime to the democratic governments. Finally, a brief discussion describes the strengths and weaknesses of the system, as well as the challenges it currently faces.El sistema de salud chileno ha sido intensamente reformado en los últimos 20 años. Las reformas bajo el gobierno de Pinochet (1973-1990 apuntaron principalmente a la descentralización del sistema y al desarrollo del sector privado. La descentralización involucró un proceso de desconcentración y la devolución de las unidades de atención primaria a las municipalidades. Los gobiernos democráticos posteriores a 1990 escogieron preservar el núcleo organizacional, pero las reformas introducidas buscaron corregir las fallas del sistema y aumentar la eficacia y la equidad. El presente artículo explica brevemente la organización actual del sistema de salud chileno y revisa las diferentes reformas introducidas en los últimos 20 años desde el régimen de Pinochet hasta los gobiernos democráticos. Finalmente, presenta una discusión breve para describir las fortalezas y debilidades del sistema, así como los desafíos que enfrenta actualmente.

  14. Occurrence of systemic lupus erythematosus in a Danish community

    DEFF Research Database (Denmark)

    Laustrup, H; Voss, A; Green, A;

    2009-01-01

    Objectives: To determine the prevalence and annual incidence of definite systemic lupus erythematosus (D-SLE) and incomplete SLE (I-SLE) in a community-based lupus cohort of predominantly Nordic ancestry in an 8-year prospective study from 1995 to 2003, and also to calculate the annual transition......-years at risk [95% confidence interval (CI) 1.44-7.55]. Conclusions: Denmark is a low-incidence lupus area but lupus prevalence is increasing slowly. I-SLE is a disease variant that may eventually convert into D-SLE....

  15. Elevated sacroilac joint uptake ratios in systemic lupus erythematosus

    International Nuclear Information System (INIS)

    Sacroiliac joint radiographs and radionuclide sacroiliac joint uptake ratios were obtained on 14 patients with active systemic lupus erythematosus. Elevated joint ratios were found unilaterally in two patients and bilaterally in seven patients when their lupus was active. In patients whose disease became quiescent, the uptake ratios returned to normal. Two patients had persistently elevated ratios with continued clinical and laboratory evidence of active lupus. Mild sacroiliac joint sclerosis and erosions were detected on pelvic radiographs in these same two patients. Elevated quantitative sacroiliac joint uptake ratios may occur as a manifestation of active systemic lupus erythematosus

  16. ¿Qué ocurre con la confianza cuando los gobiernos locales se vuelven virtuales? Explorando los determinantes de la confianza en sitios web municipales en Chile

    Directory of Open Access Journals (Sweden)

    Nicolás Somma

    2016-01-01

    Full Text Available E ste artículo explora la formación de confianza entre sitios web de gobierno local (municipales chilenos y sus grupos de interés, así como su relación con el gobierno local real. Los resultados muestran prevalencia de la confianza en el entorno virtual, por lo que se indagan sus determinantes. El artículo se basa en metodología mixta: encuesta a usuarios de Internet en Santiago de Chile, grupos focales y entrevistas a usuarios.

  17. Systemic lupus erythematosus in Nepal: A review.

    Science.gov (United States)

    Kafle, M P; Lee, Vws

    2016-08-01

    Nepal is a small country that is landlocked between India and China. Several ethnic groups live within the 147,181 km(2) of this country. Geographic diversity ranges from the high Himalayas to the flatlands of the Ganges plains. Lupus nephritis (LN), a complication of systemic lupus erythematosus (SLE), is a common kidney problem in Nepal; but the real incidence and prevalence of SLE in Nepal is largely not known. Here, it more commonly affects people (mostly women) living in the southern flatlands, but SLE is reported to be uncommon further south in India. Even though the disease appears to be common, good quality research is uncommon in Nepali literature. This article was written to provide a review of the articles published to date about SLE in Nepal and to discuss the gaps in knowledge that require further evaluation. PMID:26957353

  18. Subacute cutaneous lupus erythematosus presenting as poikiloderma.

    LENUS (Irish Health Repository)

    Hughes, R

    2012-02-01

    Subacute cutaneous lupus erythematosus (SCLE) is a recognised variant of lupus erythematosus (LE), which accounts for 10-15% of all cases of cutaneous LE, occurring most commonly in young to middle-aged white women. Diagnosis is based on the detection of anti-Ro\\/SS-A antibodies in the skin and serum, characteristic clinical and histological cutaneous involvement, and relatively mild systemic involvement. Several unusual variants of SCLE have been reported including erythrodermic SCLE, SCLE with vitiligo-like lesions, acral SCLE and bullous SCLE. Poikoilodermatous SCLE is a recognised but rare variant of SCLE. There are currently only two case reports, comprising five individual cases, in the literature. We present a case of SCLE in which the main clinical findings were an extensive photodistributed poikilodermatous rash and alopecia.

  19. Cutaneous manifestations of systemic lupus erythematosus.

    Science.gov (United States)

    Uva, Luís; Miguel, Diana; Pinheiro, Catarina; Freitas, João Pedro; Marques Gomes, Manuel; Filipe, Paulo

    2012-01-01

    Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. The skin is one of the target organs most variably affected by the disease. The American College of Rheumatology (ACR) established 11 criteria as a classificatory instrument to operationalise the definition of SLE in clinical trials. They were not intended to be used to diagnose individuals and do not do well in that capacity. Cutaneous lesions account for four of these 11 revised criteria of SLE. Skin lesions in patients with lupus may be specific or nonspecific. This paper covers the SLE-specific cutaneous changes: malar rash, discoid rash, photosensitivity, and oral mucosal lesions as well as SLE nonspecific skin manifestations, their pathophysiology, and management. A deeper thorough understanding of the cutaneous manifestations of SLE is essential for diagnosis, prognosis, and efficient management. Thus, dermatologists should cooperate with other specialties to provide optimal care of SLE patient. PMID:22888407

  20. Cutaneous Manifestations of Systemic Lupus Erythematosus

    Directory of Open Access Journals (Sweden)

    Luís Uva

    2012-01-01

    Full Text Available Systemic lupus erythematosus (SLE is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. The skin is one of the target organs most variably affected by the disease. The American College of Rheumatology (ACR established 11 criteria as a classificatory instrument to operationalise the definition of SLE in clinical trials. They were not intended to be used to diagnose individuals and do not do well in that capacity. Cutaneous lesions account for four of these 11 revised criteria of SLE. Skin lesions in patients with lupus may be specific or nonspecific. This paper covers the SLE-specific cutaneous changes: malar rash, discoid rash, photosensitivity, and oral mucosal lesions as well as SLE nonspecific skin manifestations, their pathophysiology, and management. A deeper thorough understanding of the cutaneous manifestations of SLE is essential for diagnosis, prognosis, and efficient management. Thus, dermatologists should cooperate with other specialties to provide optimal care of SLE patient.

  1. Eosinophilic gastroenteritis associated with systemic lupus erythematosus.

    Science.gov (United States)

    Barbie, David A; Mangi, Abeel A; Lauwers, Gregory Y

    2004-01-01

    Eosinophilic gastroenteritis is an uncommon disease with an obscure etiology, although associations with allergy, the idiopathic hypereosinophilic syndrome, and connective tissue disease have been reported. We present the case of a 37-year-old woman with a history of idiopathic thrombocytopenic purpura who presented with refractory nausea, vomiting, and abdominal pain. Imaging studies were significant for bowel wall thickening and ascites, while laboratory studies revealed a positive antinuclear antibody (ANA), a positive anti-double stranded (DS) DNA antibody, low complement, and proteinuria. Exploratory laparotomy with gastric and small bowel biopsies established the diagnosis of eosinophilic gastroenteritis. In addition, the patient met clinical criteria for the diagnosis of systemic lupus erythematosus. Previous studies have described eosinophilic gastroenteritis in patients with scleroderma, polymyositis, or dermatomyositis. This is the first report to our knowledge of an individual with eosinophilic gastroenteritis and systemic lupus erythematosus. PMID:15492606

  2. Cutaneous neonatal lupus erythematosus with unusual features.

    Science.gov (United States)

    Sawant, Shankar; Amladi, S T; Wadhawa, S L; Nayak, C S; Nikam, B P

    2007-01-01

    A three month-old boy was brought by his mother with complaints of multiple reddish lesions on his trunk and face since birth. The patient had erythematous annular plaques with scaling on his extremities, palms and soles with periorbital erythema and edema giving the characteristic "eye mask" or "owl's eye" appearance. His mother did not have history of any illness. Hemogram, liver and renal function tests were within normal limits. A skin biopsy was suggestive of subacute cutaneous lupus erythematosus. Immunological work-up was positive for antinuclear antibodies (ANA) (1:40) with anti-Ro titers of 3.4 and 3.47 (>1.1 = clinically significant titre) in the mother and child respectively, although negative for anti-La antibodies. The child's electrocardiogram and 2D echocardiography were normal. We are presenting a case of anti-Ro-positive cutaneous lupus erythematosus with an uncommon skin manifestation. PMID:17675734

  3. Cutaneous neonatal lupus erythematosus with unusual features

    Directory of Open Access Journals (Sweden)

    Sawant Shankar

    2007-01-01

    Full Text Available A three month-old boy was brought by his mother with complaints of multiple reddish lesions on his trunk and face since birth. The patient had erythematous annular plaques with scaling on his extremities, palms and soles with periorbital erythema and edema giving the characteristic "eye mask" or "owl′s eye" appearance. His mother did not have history of any illness. Hemogram, liver and renal function tests were within normal limits. A skin biopsy was suggestive of subacute cutaneous lupus erythematosus. Immunological work-up was positive for antinuclear antibodies (ANA (1:40 with anti-Ro titers of 3.4 and 3.47 (>1.1 = clinically significant titre in the mother and child respectively, although negative for anti-La antibodies. The child′s electrocardiogram and 2D echocardiography were normal. We are presenting a case of anti-Ro-positive cutaneous lupus erythematosus with an uncommon skin manifestation.

  4. Induction of systemic lupus erythematosus syndrome in BALB/c mice by immunization with active chromatin

    Institute of Scientific and Technical Information of China (English)

    Hong LI; Yun-yi ZHANG; Ya-nan SUN; Xi-yi HUANG; Yong-feng JIA; Duan LI

    2004-01-01

    AIM: To establish an animal model for systemic lupus erythematosus (SLE)-like syndrome in mice. METHODS:BALB/c mice were immunized with active chromatin isolated from ConA-actived syngeneic spleno-lymphocytes.Plasma samples of mice were tested by enzyme-linked immunosorbent assays (ELISA) for the presence of IgG anti-dsDNA, -ssDNA, and anti-histone antibodies. Tumor necrosis factor-α (TNF-α) in serum was measured by ELISA. Spleno-lymphocyte proliferation assays and the levels of interferon-γ (IFN-γ) in supernatants were tested respectively. Proteinuria was measured. Kidneys were examined by direct immunohistochemical method and light microscopy. RESULTS: Anti-ds DNA, ssDNA, and histone antibodies were induced in active chromatin-immunized mice, the proliferation response of splenocytes to ConA and LPS were reduced, levels of interferon-γ in supernatants and TNF-α in serum were lowered. Lupus nephritis was assessed by the presence of Ig deposits,glomerular pathology and proteinuria. CONCLUSION: The active chromatin-induced SLE-like mouse model was similar to idiopathic SLE in human.

  5. Bullous Systemic Lupus Erythematosus: Case report

    Science.gov (United States)

    Miziara, Ivan Dieb; Mahmoud, Ali; Chagury, Azis Arruda; Alves, Ricardo Dourado

    2013-01-01

    Summary Introduction: Bullous systemic lupus erythematosus (BSLE) is an autoantibody-mediated disease with subepidermal blisters. It is a rare form of presentation of SLE that occurs in less than 5% of cases of lupus. Case Report: A 27-year-old, female, FRS patient reported the appearance of painful bullous lesions in the left nasal wing and left buccal mucosa that displayed sudden and rapid growth. She sought advice from emergency dermatology staff 15 days after onset and was hospitalized with suspected bullous disease. Intravenous antibiotics and steroids were administered initially, but the patient showed no improvement during hospitalization. She displayed further extensive injuries to the trunk, axillae, and vulva as well as disruption of the bullous lesions, which remained as hyperemic scars. Incisional biopsy of a lesion in the left buccal mucosa was performed, and pathological results indicated mucositis with extensive erosion and the presence of a predominantly neutrophilic infiltrate with degeneration of basal cells and apoptotic keratinocytes. Under direct immunofluorescence, the skin showed anti-IgA, anti-IgM, and anti-IgG linear fluorescence on the continuous dermal side of the cleavage. Indirect immunofluorescence of the skin showed conjugated anti-IgA, was anti-IgM negative, and displayed pemphigus in conjunction with anti-IgG fluorescence in the nucleus of keratinocytes, consistent with a diagnosis of bullous lupus erythematosus. Discussion: BSLE is an acquired autoimmune bullous disease caused by autoantibodies against type VII collagen or other components of the junctional zone, epidermis, and dermis. It must be differentiated from the secondary bubbles and vacuolar degeneration of the basement membrane that may occur in acute and subacute cutaneous lupus erythematosus. PMID:25992032

  6. Bullous Systemic Lupus Erythematosus: Case report

    Directory of Open Access Journals (Sweden)

    Miziara, Ivan Dieb

    2014-01-01

    Full Text Available Introduction: Bullous systemic lupus erythematosus (BSLE is an autoantibody-mediated disease with subepidermal blisters. It is a rare form of presentation of SLE that occurs in less than 5% of cases of lupus. Case Report: A 27-year-old, female, FRS patient reported the appearance of painful bullous lesions in the left nasal wing and left buccal mucosa that displayed sudden and rapid growth. She sought advice from emergency dermatology staff 15 days after onset and was hospitalized with suspected bullous disease. Intravenous antibiotics and steroids were administered initially, but the patient showed no improvement during hospitalization. She displayed further extensive injuries to the trunk, axillae, and vulva as well as disruption of the bullous lesions, which remained as hyperemic scars. Incisional biopsy of a lesion in the left buccal mucosa was performed, and pathological results indicated mucositis with extensive erosion and the presence of a predominantly neutrophilic infiltrate with degeneration of basal cells and apoptotic keratinocytes. Under direct immunofluorescence, the skin showed anti-IgA, anti-IgM, and anti-IgG linear fluorescence on the continuous dermal side of the cleavage. Indirect immunofluorescence of the skin showed conjugated anti-IgA, was anti-IgM negative, and displayed pemphigus in conjunction with anti-IgG fluorescence in the nucleus of keratinocytes, consistent with a diagnosis of bullous lupus erythematosus. Discussion: BSLE is an acquired autoimmune bullous disease caused by autoantibodies against type VII collagen or other components of the junctional zone, epidermis, and dermis. It must be differentiated from the secondary bubbles and vacuolar degeneration of the basement membrane that may occur in acute and subacute cutaneous lupus erythematosus.

  7. Subacute cutaneous lupus erythematosus triggered by radiotherapy

    OpenAIRE

    Kolm, I.; Pawlik, E; Eggmann, N.; Kamarachev, J; Kerl, K. (Kornelius); French, L E; Hofbauer, G.F.L.

    2013-01-01

    BACKGROUND: The origin of collagen autoimmune diseases is not fully understood. Some studies postulate a mechanism of molecular mimicry or heterologous immunity following viral infections triggering autoimmunity. Apart from infections, other exogenous factors such as visible light or X-rays have been reported to incite autoimmunity. CASE REPORT: We report a case of histologically and serologically confirmed subacute lupus erythematosus (SCLE) following radiotherapy for breast cancer. DI...

  8. Systemic lupus erythematosus: a behavioural medicine perspective

    OpenAIRE

    Daleboudt, Gabriëlle Mathilde Nicoline

    2014-01-01

    Systemic lupus erythematosus (SLE) and its immunosuppressive treatment have a great impact on the patient’s life. Previous studies on SLE have focused on the optimisation of diagnosis and treatment. Less attention has been given to the impact of diagnosis and treatment on patients’ well-being. According to Engel’s biopsychosocial model there is a reciprocal and multifactorial relationship between disease characteristics and patients’ well-being and therefore the patient and not the disease sh...

  9. Induced murine models of systemic lupus erythematosus.

    Science.gov (United States)

    Xu, Yuan; Zeumer, Leilani; Reeves, Westley H; Morel, Laurence

    2014-01-01

    Induced mouse models of systemic lupus erythematosus (SLE) have been developed to complement the spontaneous models. This chapter describes the methods used in the pristane-induced model and the chronic graft-versus-host disease (cGVHD) model, both of which have been extensively used. We will also outline the specific mechanisms of systemic autoimmunity that can be best characterized using each of these models. PMID:24497358

  10. Brain MRI findings of neuropsychiatric lupus

    International Nuclear Information System (INIS)

    To evaluate the brain MRI findings in patients with neuropsychiatric lupus. In 26 patients (M:F = 2:24 ; aged 9-48 years) in whom the presence of systemic lupus erythematosus was clinically or pathologically proven and in whom neuropsychiatric lupus was also clinically diagnosed, the findings of brain MRI were retrospectively evaluated. MR images were analyzed with regard to the distribution, location, size and number of lesions due to cerebral ischemia or infarction, the presence of cerebral atrophy, and the extent and degree of brain parenchymal and intravascular enhancement. The most common MRI findings were lesions due to cerebral ischemia or infarction occurring in 18 patients (69%), and located within deep periventricular white matter (n=10), subcortical white matter (n=8), the cerebral cortex (n=7), basal ganglia (n=7), or brain stem or cerebellum (n=2). The lesions were single (n=3) or multiple (n=15), and in 17 patients were less than 1cm in diameter in regions other than the cerebral cortex. In six of these patients, lesions of 1-4cm in diameter in this region were combined, and one occurred in the cerebral cortex only. Cerebral atrophy was seen in 16 patients (62%), in ten of whom there was no past history of treatment with steroids for more than six months. In 15 patients (58%), contrast-enhanced MR image revealed diffuse enhancement of the basal ganglia or intravascular enhancement. In no case were MRI findings normal. The primary mainfestations of neuropsychiatric lupus are multifocal ischemia or infarctions in the cerebral cortex, and subcortical and deep white matter, and the cerebral atrophy. Contrast-enhanced MR images also demonstrated diffuse enhancement of the basal ganglia and intravascular enhancement, both thought to be related to the congestion due to the stagnation of cerebral blood flow

  11. Pregnancy-associated systemic lupus erythematosus

    OpenAIRE

    Ergin, Rahime Nida

    2014-01-01

    Systemic lupus erythematosus (SLE) is an autoimmune disease that classically manifests itself with fever, arthralgia, and rash, predominantly in women of childbearing age. The autoimmunity is against nuclear and cytoplasmic components; therefore, any organ system can be affected, and the clinical presentation spectrum is wide. Although rare, de novo SLE can be diagnosed in pregnancy. Herein, a woman who had SLE diagnosed in early pregnancy is reported. This and a previous report imply that SL...

  12. Systemic lupus erythematosus in pregnancy: Case report

    OpenAIRE

    Radeka Gordana; Novakov-Mikić Aleksandra; Mitić Igor

    2005-01-01

    Systemic lupus erythematosus (SLE) is a chronic inflammatory connective tissue disease commonly diagnosed after the age of 20, mostly around the age of 30 years. It is more common in women than in men, especially during the fertile period. Women with SLE are at higher risk for spontaneous abortions, intrauterine fetal death, preeclampsia and eclampsia, preterm delivery and intrauterine growth retardation. This paper is a case report of a pregnant woman with SLE complicated with preeclampsia, ...

  13. Systemic Lupus Erythematosus in Children and Adolescents

    OpenAIRE

    Levy, Deborah M.; Kamphuis, Sylvia

    2012-01-01

    Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that can involve any organ system with a wide range of disease manifestations, and can lead to significant morbidity and even mortality. This article reviews the epidemiology, common clinical features, complications of disease, and briefly discusses the available treatment options. In addition, important medical and psychosocial issues relevant to the pediatrician caring for children and adolescents with SLE are discussed.

  14. Cutaneous Manifestations of Systemic Lupus Erythematosus

    OpenAIRE

    Luís Uva; Diana Miguel; Catarina Pinheiro; João Pedro Freitas; Manuel Marques Gomes; Paulo Filipe

    2012-01-01

    Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. The skin is one of the target organs most variably affected by the disease. The American College of Rheumatology (ACR) established 11 criteria as a classificatory instrument to operationalise the definition of SLE in clinical trials. They were not intended to be used to diagnose individuals and do not do well in that capacity. Cutaneous lesions account for four of these...

  15. Neuropsychiatric Questionnaires in Systemic Lupus Erythematosus

    OpenAIRE

    C. Tani; Moraes-Fontes, MF; De Carli, L; Mauri, M. (Margarita); S. Bombardieri; Mosca, M.

    2014-01-01

    Patients with systemic lupus erythematosus (SLE) can be affected by a multitude of neurologic and psychiatric symptoms with a wide range of prevalence and severity. Irrespectively from attribution to SLE or other causes, neuropsychiatric (NP) symptoms strongly impact short-term and long-term outcomes,thus NP evaluation during routine clinical practice in SLE should be undertaken regularly. The assessment of NP involvement in SLE patients is challenging and the available diag...

  16. PROSPECTS FOR PHARMACOTHERAPY OF SYSTEMIC LUPUS ERYTHEMATOSUS

    Directory of Open Access Journals (Sweden)

    E. L. Nasonov

    2014-01-01

    Full Text Available The whole armory of the drugs used in rheumatology is employed to treat systemic lupus erythematosus (SLE; how- ever, most of them have not got regulatory authorities' approval and are used off-label for SLE. The successful use of a biological agent rituximab (anti-CD20 monoclonal antibodies and the registration of belimumab (anti-BLyS mono- clonal antibodies for the treatment of SLE have spurred the development of novel approaches to treating this disease. 

  17. Sweet syndrome revealing systemic lupus erythematosus.

    LENUS (Irish Health Repository)

    Quinn, N

    2015-02-01

    Sweet Syndrome is an acute inflammatory skin eruption which is rare in children. We report a case of childhood Systemic Lupus Erythematosus (SLE) that presented with Sweet syndrome. This case is a unique presentation of a common disorder which provides a new facet for the differential diagnosis of SLE in children. It is also the first paediatric case to be reported in a Caucasian child.

  18. La nación en el discurso de la derecha. Un análisis ideológico del debate parlamentario chileno

    Directory of Open Access Journals (Sweden)

    Antonieta Muñoz-Navarro

    2008-01-01

    Full Text Available Este trabajo se enmarca en la comunicación política y estudia el discurso parlamentario chileno, específicamente el discurso senatorial conservador. La tesis planteada es que la concepción de nación tradicional, formulada como ideología, impide perfeccionar la democracia chilena y, específicamente, se usa contra las aspiraciones de representatividad del principal pueblo indígena chileno: los Mapuche. A partir del análisis del discurso ideológico, se observan los debates parlamentarios chilenos pertenecientes a los partidos políticos conservadores, referidos al pueblo mapuche. El estudio revela que los principios del Estado-Nación liberal están presentes en el discurso senatorial y se usan para evitar la participación política. Asociado a esto tenemos un hallazgo adicional de discurso clásico de una ideología racista. Finalizamos el estudio, destacando formas de profundizar el estudio y especulando sobre posibles alternativas políticas que, dada esta realidad, puedan ser eficaces en la construcción democrática chilena.

  19. Filaments in the Lupus molecular clouds

    CERN Document Server

    Benedettini, M; Pezzuto, S; Elia, D; André, P; Könyves, V; Schneider, N; Tremblin, P; Arzoumanian, D; di Giorgio, A M; Di Francesco, J; Hill, T; Molinari, S; Motte, F; Nguyen-Luong, Q; Palmeirim, P; Rivera-Ingraham, A; Roy, A; Rygl, K L J; Spinoglio, L; Ward-Thompson, D; White, G J

    2015-01-01

    We have studied the filaments extracted from the column density maps of the nearby Lupus 1, 3, and 4 molecular clouds, derived from photometric maps observed with the Herschel satellite. Filaments in the Lupus clouds have quite low column densities, with a median value of $\\sim$1.5$\\times$10$^{21}$ cm$^{-2}$ and most have masses per unit length lower than the maximum critical value for radial gravitational collapse. Indeed, no evidence of filament contraction has been seen in the gas kinematics. We find that some filaments, that on average are thermally subcritical, contain dense cores that may eventually form stars. This is an indication that in the low column density regime, the critical condition for the formation of stars may be reached only locally and this condition is not a global property of the filament. Finally, in Lupus we find multiple observational evidences of the key role that the magnetic field plays in forming filaments, and determining their confinement and dynamical evolution.

  20. Catatonia due to systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    Francisco de Assis Pinto Cabral Júnior Rabello

    2014-07-01

    Full Text Available Objectives Discuss neuropsychiatric aspects and differential diagnosis of catatonic syndrome secondary to systemic lupus erythematosus (SLE in a pediatric patient. Methods Single case report. Result A 13-year-old male, after two months diagnosed with SLE, started to present psychotic symptoms (behavioral changes, hallucinations and delusions that evolved into intense catatonia. During hospitalization, neuroimaging, biochemical and serological tests for differential diagnosis with metabolic encephalopathy, neurological tumors and neuroinfections, among other tests, were performed. The possibility of neuroleptic malignant syndrome, steroid-induced psychosis and catatonia was also evaluated. A complete reversal of catatonia was achieved after using benzodiazepines in high doses, associated with immunosuppressive therapy for lupus, which speaks in favor of catatonia secondary to autoimmune encephalitis due to lupus. Conclusion Although catatonia rarely is the initial clinical presentation of SLE, the delay in recognizing the syndrome can be risky, having a negative impact on prognosis. Benzodiazepines have an important role in the catatonia resolution, especially when associated with parallel specific organic base cause treatment. The use of neuroleptics should be avoided for the duration of the catatonic syndrome as it may cause clinical deterioration.

  1. Filaments in the Lupus molecular clouds

    Science.gov (United States)

    Benedettini, M.; Schisano, E.; Pezzuto, S.; Elia, D.; André, P.; Könyves, V.; Schneider, N.; Tremblin, P.; Arzoumanian, D.; di Giorgio, A. M.; Di Francesco, J.; Hill, T.; Molinari, S.; Motte, F.; Nguyen-Luong, Q.; Palmeirim, P.; Rivera-Ingraham, A.; Roy, A.; Rygl, K. L. J.; Spinoglio, L.; Ward-Thompson, D.; White, G. J.

    2015-10-01

    We have studied the filaments extracted from the column density maps of the nearby Lupus 1, 3, and 4 molecular clouds, derived from photometric maps observed with the Herschel satellite. Filaments in the Lupus clouds have quite low column densities, with a median value of ˜1.5 × 1021 cm-2 and most have masses per unit length lower than the maximum critical value for radial gravitational collapse. Indeed, no evidence of filament contraction has been seen in the gas kinematics. We find that some filaments, that on average are thermally subcritical, contain dense cores that may eventually form stars. This is an indication that in the low column density regime, the critical condition for the formation of stars may be reached only locally and this condition is not a global property of the filament. Finally, in Lupus we find multiple observational evidences of the key role that the magnetic field plays in forming filaments, and determining their confinement and dynamical evolution.

  2. Monoclonal Antibodies for Systemic Lupus Erythematosus (SLE

    Directory of Open Access Journals (Sweden)

    Gabriella Moroni

    2010-01-01

    Full Text Available A number of monoclonal antibodies (mAb are now under investigation in clinical trials to assess their potential role in Systemic Lupus Erythematosus (SLE. The most frequently used mAb is rituximab, which is directed against CD20, a membrane protein expressed on B lymphocytes. Uncontrolled trials reported an improvement of SLE activity in non-renal patients and other studies even reported an improvement of severe lupus nephritis unresponsive to conventional treatments. However two randomized trials failed to show the superiority of rituximab over conventional treatment in non renal SLE and in lupus nephritis. Preliminary trials reported promising results with epratuzumab, a humanized mAb directed against CD22, and with belimumab, a human mAb that specifically recognizes and inhibits the biological activity of BLyS a cytokine of the tumornecrosis-factor (TNF ligand superfamily. Other clinical trials with mAb directed against TNF-alpha, interleukin-10 (Il-10, Il-6, CD154, CD40 ligand, IL-18 or complement component C5 are under way. At present, however, in spite of good results reported by some studies, no firm conclusion on the risk-benefit profile of these mAbs in patients with SLE can be drawn from the available studies.

  3. Classifying Lupus Nephritis: An Ongoing Story

    Directory of Open Access Journals (Sweden)

    Saba Kiremitci

    2014-01-01

    Full Text Available The role of the renal biopsy in lupus nephritis is to provide the diagnosis and to define the parameters of prognostic and therapeutic significance for an effective clinicopathological correlation. Various classification schemas initiated by World Health Organization in 1974 have been proposed until the most recent update by International Society of Nephrology/Renal Pathology Society in 2004. In this paper, we reviewed the new classification system with the associated literature to highlight the benefits and the weak points that emerged so far. The great advantage of the classification emerged to provide a uniform reporting for lupus nephritis all over the world. It has provided more reproducible results from different centers. However, the studies indicated that the presence of glomerular necrotizing lesion was no longer significant to determine the classes of lupus nephritis leading to loss of pathogenetic diversity of the classes. Another weakness of the classification that also emerged in time was the lack of discussions related to the prognostic significance of tubulointerstitial involvement which was not included in the classification. Therefore, the pathogenetic diversity of the classification still needs to be clarified by additional studies, and it needs to be improved by the inclusion of the tubulointerstitial lesions related to prognosis.

  4. Lupus eritematoso neonatal: reporte de cuatro casos Neonatal lupus erythematosus: a report of four cases

    OpenAIRE

    Maria Fernanda Perez; Maria Eugenia de Torres; María Marta Buján; Agustina Lanoël; Andrea Bettina Cervini; Adrián Martín Pierini

    2011-01-01

    El lupus eritematoso neonatal es una enfermedad poco frecuente, caracterizada clínica mente por alteraciones cutáneas semejantes al lupus subagudo o discoide y/o bloqueo cardíaco congénito. Generalmente, cuando los pacientes presentan manifestaciones cutáneas, no tienen anormalidades cardiológicas y viceversa, aunque en un 10% de los casos ambas manifestaciones pueden coexistir. Puede acompañarse también de alteraciones hematológicas, hepáticas y neurológicas. Es causado por el pasaje traspla...

  5. Confiabilidad y validez de la Escala de Déficit Atencional (EDAH) adaptada en estudiantes chilenos

    OpenAIRE

    2015-01-01

    Antecedentes. Las necesidades de atención en salud mental infantil hacen necesario contar con estudios epidemiológicos que sirvan de base para perfeccionar las intervenciones y acrecentar el diagnóstico, con instrumentos fiables y adecuados al contexto. Objetivo. El objetivo de este estudio fue analizar las propiedades psicométricas de la Escala para la Evaluación del Trastorno por Déficit Atencional (EDAH), en escolares de primaria y secundaria de Chile. Método. Se evaluó una muestra de 508 ...

  6. Trabajo a tiempo parcial: análisis del caso chileno.

    OpenAIRE

    Tomás Rau Binder

    2008-01-01

    Este artículo analiza la evolución del trabajo a tiempo parcial en Chile y los factores económicos, tanto de oferta como demanda, que lo afectan. Se incorpora un análisis a la regulación y se proponen algunas medidas para incrementar su participación relativa sobre otras jornadas laborales, sobre el supuesto de deseabilidad de jornadas laborales flexibles que incentiven especialmente la participación femenina. Se concluye con un análisis de cadenas de Markov usando el Panel Casen con el cual ...

  7. Bladder involvement in systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    Eric Roger Wroclawski

    2009-12-01

    Full Text Available Objective: To study bladder involvement in systemic lupus erythematosus patients through clinical and laboratorial evaluation, ultrasonography, radiological and endoscopic examination. Methods: Thirty-nine patients, either outpatients or inpatients at the Department of Rheumatology of Hospital das Clínicas da Faculdade de Medicina from Universidade de São Paulo were evaluated as to clinical and laboratorial data. All patients were submitted to ultrasonographic evaluation of the upper urinary tract, radiological and endoscopic examinations of the middle and lower urinary tracts. Rresults: Mean age of patients varied between 13 and 62 years (median = 29 years. Thirty-six were females and three were males. The disease varied from 6 months to 22 years (median three years and one month. Clinical and laboratory activity of the disease was present in 30 patients. Twenty-two patients had the diagnosis of lupus established for three years or more. Twenty-five patients were asymptomatic and all had received corticosteroids for treatment at least once. Twenty-three received antimalarial drugs; ten received cytostatics, and seven patients received non-steroid anti-inflammatory drugs. Upper urinary tract ultrasonography was normal in all cases but one with staghorn calculus associated with neurogenic bladder secondary to neurological involvement by the disease. Vesicoureteral reflux was observed in two cases. Other two patients had significant post-voiding residual urine, both with neurogenic bladder secondary to nervous system involvement by lupus. The average bladder maximum capacity in an awaken patient was 342 mL, and was decreased in 18.9% of cases. This subgroup of patients presented a greater frequency of urinary symptoms and greater use of cytostatic drugs (Z > Z5%. A pathognomonic cystoscopic pattern of bladder involvement in systemic lupus erythematosus could not be established. Cystoscopic aspects similar to those seen in the initial or minor

  8. Unique Protein Signature of Circulating Microparticles in Systemic Lupus Erythematosus

    DEFF Research Database (Denmark)

    Østergaard, Ole; Nielsen, Christoffer; Iversen, Line V;

    2013-01-01

    To characterize the unique qualities of proteins associated with circulating subcellular material in systemic lupus erythematosus (SLE) patients compared with healthy controls and patients with other chronic autoimmune diseases.......To characterize the unique qualities of proteins associated with circulating subcellular material in systemic lupus erythematosus (SLE) patients compared with healthy controls and patients with other chronic autoimmune diseases....

  9. A pathophysiology-based approach to the diagnosis and treatment of lupus nephritis.

    Science.gov (United States)

    Anders, Hans-Joachim; Rovin, Brad

    2016-09-01

    Lupus is no longer an unknown chameleon of medicine. Significant progress has been made on unraveling the pathogenesis of lupus and lupus nephritis, and how to treat the disease. Here we provide an update on the pathophysiology of lupus and its related kidney disease, consider areas of controversy in disease management, and discuss the unmet needs of lupus nephritis and how to address these needs. We focus on rethinking how innovative therapies for lupus nephritis should be evaluated and evolving strategies to more efficiently mitigate irreversible nephron loss in patients with lupus nephritis. PMID:27378475

  10. Prognosis and predictors of convulsion among pediatric lupus nephritis patients

    International Nuclear Information System (INIS)

    In this study, we aimed to analyze features and outcome of convulsion in pediatric lupus nephritis patients. We retrospectively reviewed data of 14 Iranian children with lupus nephritis who developed seizures and compared them with a group of the same number of well matched pediatric lupus nephritis patients. Higher serum creatinine levels and higher frequencies of anemia and lymphopenia were observed in the convulsion group. Multivariable logistic regression analysis revealed that the only risk factor for development of convulsion in pediatric lupus patients with nephritis was lymphopenia. Survival analysis showed that convulsion had no impact on patient and renal function outcomes in our pediatric lupus nephritis subjects. In conclusion, we found that lymphopenia is a predictive factor for convulsion occurrence in our patients and special attention to neurological status assessment may be needed in this situation. (author)

  11. Pregnancy in women with systemic lupus erythematosus (SLE).

    Science.gov (United States)

    Moroni, Gabriella; Ponticelli, Claudio

    2016-07-01

    For many years pregnancy has been contraindicated in patients with SLE, particularly when kidney involvement was present. Today, pregnancy is no longer considered impossible in women with lupus. Yet, lupus pregnancies are still considered high-risk. The prognosis has considerably improved for pregnant women but the fetal risk, although progressively reduced, is still higher in pregnancies of patients with SLE than in pregnancies of healthy women. Miscarriage, premature delivery, and preeclampsia, as well as heart problems in the baby are the major complications that can occur. In this paper we will review the outcome of pregnant women with SLE, the influence of lupus on fetal outcome, the effects of pregnancy on lupus, and the management of pregnant lupus patients based on our personal experience and the revision of the most recent and significant papers on the subject. PMID:27142327

  12. Prognosis and predictors of convulsion among pediatric lupus nephritis patients

    Directory of Open Access Journals (Sweden)

    Beiraghdar Fatemeh

    2009-01-01

    Full Text Available In this study, we aimed to analyze features and outcome of convulsion in pediatric lupus nephritis patients. We retrospectively reviewed data of 14 Iranian children with lupus nephritis who developed seizures and compared them with a group of the same number of well matched pe-diatric lupus nephritis patients. Higher serum creatinine levels and higher frequencies of anemia and lymphopenia were observed in the convulsion group. Multivariable logistic regression analysis re-vealed that the only risk factor for development of convulsion in pediatric lupus patients with ne-phritis was lymphopenia. Survival analysis showed that convulsion had no impact on patient and renal function outcomes in our pediatric lupus nephritis subjects. In conclusion, we found that lympho-penia is a predictive factor for convulsion occurrence in our patients and special attention to neuro-logical status assessment may be needed in this situation.

  13. Lupus Headaches in 55 Childhood-Onsets SLE

    Directory of Open Access Journals (Sweden)

    Mohammad Hassan Moradinejad

    2007-05-01

    Full Text Available Objective: Although headache is a common complaint among patients with lupus, no universally accepted explanation was available until the International Headaches Society adopted Lupus headache as a Nomenclature in its classification recently. Few studies indicate that lupus patients with positive anti-nuclear antibody (ANA and positive antiphospholipid antibodies (aPL experience more frequent headaches. The aim of this study was to determine the correlation between headache frequencies and ANA, anti-double strand DNA (anti-ds-DNA and aPL positivity. Material & Methods: In this prospective multicenter study were enrolled 55 children, 45 girls and 10 boys (F/M ratio:4.5, aged 3-16 years (mean 11.5 years, with neuropsychiatric lupus complaining of headache, that where followed-up for 5 years.. Whether lupus headache is a sign of progressive nature of the disease and how it should be treated is not clear yet. Those with active disease, hypertension, or tension headache were not included in this study. Findings: We studied 55 children with definite lupus. Twenty three (43% of our patients developed new or significantly worse, persistent headaches that sometimes were similar to migraine in the early course of their disease. However their headaches were not accompanied with disease flare up and the headaches were not found to be related to hypertension or use of other medications either. Accordingly, we came to a diagnosis of lupus headache for these patients. Among them 19/55 cases (35% had a positive aPL and 53/55 cases (96% had a positive ANA. Conclusion: Lupus headaches are most likely multifactorial, and probably only a small proportion of them truly represent active lupus. The above data highlights probable correlation between aPL, ANA, an anti-ds-DNA and lupus headache. However, more research is required to find better treatments and to establish a definitive correlation among them.

  14. Husbandry practices associated with the presentation of abnormal behaviours in Chilean Creole horses Prácticas de manejo asociadas a la presentación de conductas anormales en caballos Criollo chileno

    Directory of Open Access Journals (Sweden)

    T Tadich

    2012-01-01

    manejo. Se encuestaron 23 criaderos contemplando información del animal y de manejo. Se obtuvo información de 441 equinos, 116 fueron menores de un año, grupo que no presentó conductas anormales. De los 325 equinos adultos un 11% presentó conductas anormales de las cuales 3,1% corresponde a estereotipias y 8% a otras conductas anormales, siendo la lignofagia la más frecuente en este último grupo. Se encontró una asociación significativa entre la presentación de conductas anormales y la categoría semental, mientras que la función también se asoció de forma significativa con la presentación de conductas anormales, siendo la realización de dos funciones (reproducción y deporte de mayor riesgo. En relación al manejo se encontró una asociación significativa entre la entrega de menos de 60% de forraje en la ración y la presentación de conductas anormales. Un 41% permanece más de 6 horas estabulado; 37% no tiene contacto conespecífico entre establos; y sólo el 21% ocupa cama de paja. Estas prácticas no se asociaron significativamente a la presentación de conductas anormales. El establecer factores de riesgo para la presentación de conductas anormales permitirá implementar prácticas de manejo adecuadas en los sistemas de producción del caballo Criollo chileno, y con ello mejorar el bienestar de esta raza.

  15. The systemic lupus erythematosus travel burden survey: baseline data among a South Carolina cohort

    OpenAIRE

    Williams, Edith M.; Ortiz, Kasim; Zhang, Jiajia; Zhou, Jie; Kamen, Diane

    2016-01-01

    Background Many studies on the impact of systemic lupus erythematosus or lupus have identified patient travel costs as being problematic. We administered a survey that examined the impact of self-rated travel burden on lupus patients. The systemic lupus erythematosus travel burden survey included 41 patients enrolled in the systemic lupus erythematosus database project at the Medical University of South Carolina. Results Most participants reported that travel caused medications to be disconti...

  16. Geographical distribution, a risk factor for the incidence of lupus nephritis in China

    OpenAIRE

    Pan, Qingjun; Li, Yaning; Ye, Ling; Deng, Zhenzhen; Li, Lu; Feng, Yongmin; Liu, Weijing; LIU, HUAFENG

    2014-01-01

    Background Geographical variation in lupus nephritis epidemiology may indicate important environmental factors contributions to the etiology of lupus nephritis. This paper first describes the epidemiology of biopsy-proven lupus nephritis in China by performing a systematic literature review and the possible social-environmental influential factors. Methods The keywords “lupus nephritis”, “renal biopsy” and “systemic lupus erythematous” were searched in the three largest Chinese electronic dat...

  17. El 'voseo mixto verbal' de hablantes chilenos en Montreal: Estudio de caso en un contexto de contacto dialectal VERBAL VOSEO AMONG CHILEAN SPEAKERS IN MONTREAL: A CASE STUDY IN A DIALECT CONTACT SITUATION

    Directory of Open Access Journals (Sweden)

    Víctor Fernández Mallat

    2011-07-01

    Full Text Available La presencia de numerosos hispanohablantes, de diversos orígenes, en la ciudad canadiense de Montreal suscita una situación de contacto lingüístico entre distintas variedades del español. A pesar del interés que esta situación ofrece para la lingüística hispanoamericana, hasta donde tenemos constancia, no ha habido estudios sobre los posibles efectos del contacto dialectal sobre el español de migrantes de primera y segunda generación en Montreal. Precisamente en esta línea de trabajo, el presente artículo pretende ser una primera contribución a este campo de estudio, en concreto sobre el español de migrantes chilenos. De este modo, y gracias a un corpus oral de conversaciones libres, se propone analizar qué ocurre con el fenómeno del voseo mixto verbal en el habla de un grupo de informantes de ese origen.Due to the presence of several groups of Spanish speakers of various backgrounds, a language contact environment exists among different varieties of Spanish in the Canadian city of Montreal. Despite the possibilities that this situation offers to the field of American Spanish Linguistics, no study, as far as we know, has been undertaken to determine the effects of dialect contact on first- and second-generation migrants' Spanish. With this article, we aim to make the first contribution to this area of study; in particular, we focus on the Spanish of Chilean migrants. Using a corpus of naturally-occurring conversations, we analyze the verbal voseo feature in the speech of these migrants.

  18. Revisión sobre aspectos biológicos y de cultivo del lenguado chileno (Paralichthys adspersus Review of the biology and cultivation of Chilean flounder (Paralichthys adspersus

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    Alfonso Silva

    2010-01-01

    Full Text Available El lenguado chileno (Paralichthys adspersus es una especie endémica de la costa chilena, que ha sido objeto de diversos estudios tendientes a analizar las posibilidades que presenta para diversificar la acuicultura marina. El presente trabajo hace una revisión de los diversos resultados obtenidos en el estudio de su biología y técnicas de cultivo, observándose que existe el conocimiento zootécnico necesario para desarrollar su ciclo biológico completo en cautividad y producir individuos de tamaño comercial en condiciones de cultivo. Sin embargo, este conocimiento se encuentra disperso y aún muestra comparativamente con otras especies cultivables, una moderada replicabilidad de los resultados, lo que implica la necesidad de persistir en la optimización de algunos aspectos de su cultivo, para impulsar definitivamente su desarrollo.Chilean flounder (Paralichthys adspersus are endemic to the Chilean coast and have been the subject of several studies on the possible diversification of marine aquaculture. This paper reviews the diverse results obtained from studies of this species' biology and cultivation techniques. The biological and technical knowledge available is sufficient for developing the entire life cycle of this species, producing commercial-sized individuals, in captivity. However, this knowledge is disperse and the results, as compared with those for other harvested species, still show moderately reproducible results, implying the need to continue efforts to optimize some aspects of Chilean flounder cultivation, thereby promoting the species' development definitely.

  19. RESPUESTA DE DOS AISLAMIENTOS CHILENOS DE Metarhizium anisopliae (METSCHNIKOFF SOROKIN A LA ADICIÓN DE UN PROTECTOR SOLAR Response of two Chilean Metarhizium anisopliae (Metschnikoff Sorokin isolates to the addition of a solar sunscreen

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    Luis Devotto M.

    2003-10-01

    Full Text Available Dos aislamientos chilenos de Metarhizium anisopliae (Metchsnikoff Sorokin fueron expuestos a dosis crecientes de luz ultravioleta (UV, en condiciones de laboratorio. Conidias en suspensión acuosa fueron esparcidas en placas Petri con agar y éstas fueron puestas bajo una lámpara de luz UV-C (lambda = 254 nm. Sin el protector solar, la exposición de las conidias durante 40 s redujo su germinación de 80-95% a sólo 5-2%, para QU-M221b y QU-M363, respectivamente. Usando el protector solar Blankophor P167® al 1% p/v, la germinación de las conidias, tras 40 s de exposición, se redujo desde 68-82% a 50-33% para QU-M221b y QU-M363, respectivamente. Los resultados indican que este protector solar es un potencial adjuvante para ser usado en biopesticidas basados en M. anisopliae.Two Chilean isolates of Metarhizium anisopliae (Metschnikoff Sorokin (QU-M363 and QU-M221b were exposed to increasing doses of ultraviolet light (UV under laboratory conditions. Conidia suspended in aqueous solution were spread on Petri dishes containing agar-agar and were placed under a UV lamp (lambda = 254 nm. Without sunscreen, exposure of conidia to UV-C light reduced germination after 40 s from 80-95% to 5-2%, for QU-M221b and QU-M363, respectively. Using the solar screen Blankophor P167® at 1% w/v, conidia germination decreased after 40 s from 68-82% to 50-33% for QU-M221b and QU-M363, respectively. Results indicate that the sunscreen Blankophor P167 is a potential adjuvant to be used in biopesticides based on M. anisopliae.

  20. Metabolic syndrome in patients with systemic lupus erythematosus: association with traditional risk factors for coronary heart disease and lupus characteristics.

    Science.gov (United States)

    Telles, Rw; Lanna, Ccd; Ferreira, Ga; Ribeiro, Al

    2010-06-01

    The objective of this study was to determine the frequency of Metabolic Syndrome (MetS) in patients with SLE and to analyze the association of MetS with traditional risk factors for CHD and lupus characteristics. In this cross-sectional study the frequency of MetS was determined according to the National Cholesterol Education Program Adult Treatment Panel III in patients with SLE. The association of MetS with the traditional risk factors for CHD not included in the syndrome definition, and with lupus characteristics was examined. The mean age (sd) of the 162 females patients was 38.8(11.2) years. The frequency of MetS was 32.1%. Abdominal obesity and hypertension were the two most common components of the syndrome (86.5% each) followed by low levels of HDL-cholesterol (84.6%), hypertriglyceridemia (69.2%) and hyperglycemia (15.4%). MetS was significantly associated with older age, family history of CHD, obesity, postmenopausal status, LDL-c > or =100mg/dl, and higher Framingham risk score. Lupus characteristics associated with MetS were history of nephrotic proteinuria during follow-up and current cyclophosphamide use, higher modified SLEDAI-2k, higher damage index score (SLICC/ACR), and older age at lupus diagnosis. In the logistic regression analysis, obesity, LDL-c > or =100mg/dl, older age at lupus diagnosis, higher damage index and nephrotic proteinuria were independently associated with MetS. We conclude that MetS diagnosis was frequent in patients with lupus. The syndrome was associated not only with traditional risk factors for CHD, confirming the clustering of those risk factors, but also with lupus characteristics. Some of those factors, especially LDL-c > or =100mg/dl and age at lupus diagnosis, have been associated with atherosclerosis in lupus patients. Lupus (2010) 19, 803-809. PMID:20118159

  1. Usos del celular en jóvenes chilenos de bajos recursos

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    Margarita Pedreros-Gajardo

    2013-03-01

    Full Text Available En este trabajo analizamos los significados que los jóvenes y las jóvenes de Chile de bajos recursos atribuyen a la compra, uso y tenencia de un celular. La investigación cualitativa utilizada no sólo nos permitió descubrir las necesidades que los sujetos jóvenes buscan satisfacer con la compra y/o uso de un celular, sino también los factores socioculturales que determinan este comportamiento de compra. La importancia del presente no es sólo por la pretensión de ser un estudio sociológico sobre la conducta de compra, uso y tenencia de celular por parte de los jóvenes y las jóvenes de Chile de menores recursos, sino también porque constituye una poderosa herramienta para comprender los problemas sociales relacionados con este hecho.

  2. Adaptaciones curriculares: Convergencias y divergencias de su implementación en el profesorado chileno

    Directory of Open Access Journals (Sweden)

    Braulio Ademir Navarro-Aburto

    2016-01-01

    Full Text Available Recibido 13 de marzo de 2015 • Corregido 29 de octubre de 2015 • Aceptado 17 de noviembre de 2015La presente investigación describe el proceso que se realiza para llevar a cabo las adaptaciones curriculares, en la asignatura de matemática para el alumnado que presenta algún tipo de necesidad educativa especial transitoria. Se ha considerado la coordinación existente entre docentes de Matemática y de Educación Diferencial, como acción promotora de las adaptaciones curriculares. La metodología utilizada corresponde a la cualitativa con un enfoque fenomenológico, y la principal técnica de recolección de datos fue la entrevista semiestructurada, participantes de este estudio fueron 10 docentes de 2 instituciones educativas con programa de integración. Los principales hallazgos arrojan que profesorado y personal encargados del Programa de Integración Escolar cumplen con las normativas y requerimientos  del Decreto Nº 170 en relación con las adaptaciones curriculares, pero dicho cumplimiento está sujeto a la informalidad en la articulación y planificación debido a la falta de tiempo y recursos disponibles. De este modo, como conclusión se plantea que existe una necesidad constante de adaptaciones curriculares, pues son un mecanismo que permite lograr la individualización de la enseñanza, mejorando la calidad de vida y la educación especial en Chile.

  3. Refractory disease in systemic lupus erythematosus.

    Science.gov (United States)

    Campar, Ana; Farinha, Fátima; Vasconcelos, Carlos

    2011-09-01

    There is no definition or guidelines for refractory disease (RD) in Systemic Lupus Erythematosus (SLE). However, new therapies have been tested mainly in refractory patients. The concept, like the disease, is complex and implies deeper knowledge on the disease pathogenesis and patients' subsets. RD is not included in current activity indices of the disease, what raises the question of how are we monitoring its response to new drugs. In this paper, we analyse some concepts considered important for the global definition of RD in SLE and in some specific organ involvements, excluding lupus nephritis. Management issues will be addressed also. Finally, we review therapeutic options in particular subsets of the disease, namely, cutaneous, articular, haematological and neuropsychiatric lupus. Crucial to the management of a patient suspected to be refractory is an accurate diagnosis, assuring that the persistent clinical manifestations are derived primarily from SLE and not from a concomitant or alternative process. Likewise, certainty about the patient compliance with the therapy prescribed is a frequent unrecognized problem that erroneously might lead to a classification of RD. Therapy of RD for SLE, in general and in most particular involvements, is currently based mainly on the clinician's own experience and judgement, with few randomized trials effectively addressing the issue. In such a heterogeneous disease, consideration of approval of drugs for single-organ indications may pave the way for new therapies. Better biomarkers are needed to add accuracy to the currently used activity indices in order to monitor RD and consolidate its definition. Prospective studies directed to RD in the main SLE involvements are needed to improve our understanding on the management of the disease and foster the development of targeted new drugs. PMID:21600313

  4. C1q and systemic lupus erythematosus.

    Science.gov (United States)

    Walport, M J; Davies, K A; Botto, M

    1998-08-01

    In this chapter we review the association between SLE and C1q. In the first part of the chapter we discuss the clinical associations of C1q deficiency, and tabulate the available information in the literature relating to C1q deficiency and autoimmune disease. Other clinical associations of C1q deficiency are then considered, and we mention briefly the association between other genetically determined complement deficiencies and lupus. In the review we explore the relationship between C1q consumption and lupus and we discuss the occurrence of low molecular weight (7S) C1q in lupus, which raises the possibility that increased C1q turnover in the disease may result in unbalanced chain synthesis of the molecule. Anti-C1q antibodies are also strongly associated with severe SLE affecting the kidney, and with hypocomplementaemic urticarial vasculitis, and these associations are also examined. We address the question of how C1q deficiency may cause SLE, discussing the possibility that this may be due to abnormalities of immune complex processing, which have been well characterised in a umber of different human models. There is clear evidence that immune complex processing is abnormal in patients with hypocomplementaemia, and this is compatible with the hypothesis that ineffective immune complex clearance could cause tissue injury, and this may in turn stimulate an autoantibody response. We have also considered the possibility that C1q-C1q receptor interactions are critical in the regulation of apoptosis, and we explore the hypothesis that dysregulation of apoptosis could explain important features in the development of autoimmune disease associated with C1q deficiency. An abnormally high rate of apoptosis, or defective clearance of apoptotic cells, could promote the accumulation of abnormal cellular products that might drive an autoimmune response. Anti-C1q antibodies have been described in a number of murine models of lupus, and these are also briefly discussed. We focus

  5. Autoantibody profiling in systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    Hsieh SC

    2013-08-01

    Full Text Available Song-Chou Hsieh,1 Chia-Li Yu1,2 1Department of Internal Medicine, 2Institute of Molecular Medicine, National Taiwan University College of Medicine, Taipei, Taiwan Abstract: Systemic lupus erythematosus (SLE is an archetype of systemic autoimmune disease characterized by the production of a broad spectrum of autoantibodies. More than 100 autoantibodies have been found in the sera of patients with SLE, including antibodies against nuclear, cytoplasmic, surface-membrane, and extracellular antigens. There has been considerable debate as to whether these antinuclear autoantibodies (ANAs are merely biomarkers for disease or are responsible for organ/tissue damage in SLE. In recent years, sufficient evidence has supported the hypothesis that many ANAs, such as anti-double-stranded DNA (anti-dsDNA, antiribosomal P, anti-Sm, antiribonucleoprotein (anti-RNP, and even anti-Sjögren's syndrome (SS-B/La antibodies not only act against specific nuclear antigens but also cross-react with different surface-expressed cognate molecules. The binding of autoantibodies to the cell surface leads to their penetration into the cell's interior to elicit cellular damage. There are at least four conceivable routes for ANAs to penetrate the cytoplasm: (1 nonspecific Fcγ receptor-mediated uptake, (2 cell-surface caveolae-mediated endocytosis, (3 electrostatic interactions between positively charged amino acids of the complementarity-determining regions of the antibody molecule and the negatively charged surface membrane, and (4 the binding of the autoantibody with its cross-reactive cell surface-expressed cognate molecule, and its subsequent endocytosis into the cytoplasm. In this review, we discuss in detail the immunopathogenic mechanisms of the commonly encountered ANAs, such as anti-dsDNA, antiribosomal P, and anti-SSB/La, that are associated with lupus pathogenesis. Additionally, the detrimental thromboembolism-inducing anticardiolipin antibodies in patients with SLE

  6. Systemic lupus erythematosus in pregnancy: Case report

    Directory of Open Access Journals (Sweden)

    Radeka Gordana

    2005-01-01

    Full Text Available Systemic lupus erythematosus (SLE is a chronic inflammatory connective tissue disease commonly diagnosed after the age of 20, mostly around the age of 30 years. It is more common in women than in men, especially during the fertile period. Women with SLE are at higher risk for spontaneous abortions, intrauterine fetal death, preeclampsia and eclampsia, preterm delivery and intrauterine growth retardation. This paper is a case report of a pregnant woman with SLE complicated with preeclampsia, but it also discusses follow-up of such pregnancies.

  7. Lupus as a paraneoplastic manifestation of cholangiocarcinoma.

    Science.gov (United States)

    González Amores, Yolanda; Hernando Rebollar, Sofía; Casado Bernabeu, Aida

    2016-05-01

    Tumors originating in the digestive system, like those in other areas, whether solid or otherwise, may present with extradigestive manifestations in the setting of a paraneoplastic syndrome. Systemic lupus erythematosus (SLE) is an autoimmune condition most commonly involving women of childbearing age. On occasion it represents a paraneoplastic manifestation heralding a primary tumor. Cancer suspicion is therefore a key element for newly diagnosed SLE cases with nonstandard epidemiology even in the absence of suggestive symptoms, and digestive tumors should be included in the differential diagnosis. PMID:26925842

  8. Systemic lupus erythematosus : abdominal radiologic findings

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Jae Cheon; Cho, On Koo; Lee, Yong Joo; Bae, Jae Ik; Kim, Yong Soo; Rhim, Hyun Chul; Ko, Byung Hee [Hanyang Univ. College of Medicine, Seoul (Korea, Republic of)

    1999-06-01

    Systemic lupus erythematosus(SLE) is a systemic disease of unknown etiology. Its main pathology is vasculitis and serositis, due to deposition of the immune complex or antibodies. Most findings are nonspecific ; abdominal manifestations include enteritis, hepatomegaly, pancreatic enlargement, serositis, lymphadenopathy, splenomegaly, nephritis, interstitial cystitis, and thrombophlebitis. We described radiologic findings of various organ involvement of SLE; digestive system, serosa, reticuloendothelial system, urinary system, and venous system. Diagnosis of SLE was done according to the criteria of American Rheumatism Association. Understanding of the variable imaging findings in SLE may be helpful for the early detection of abdominal involvement and complications.

  9. Systemic lupus erythematosus: Clinical and experimental aspects

    International Nuclear Information System (INIS)

    This text covers questions related to the history, etiology, pathogenesis, clinical aspects and therapy of systematic lupus erythematosus (SLE). Both animal models and human SLE are considered. With regard to basic science, concise information on cellular immunology, autoantibodies, viral aspects and molecular biology in SLE is provided. Clinical topics then deal with medical, dermatologic, neurologic, radiologic, pathologic, and therapeutic aspects. The book not only presents the most recent information on clinical and experimental insights, but also looks at future aspects related to the diagnosis and therapy of SLE

  10. Desafíos claves del fortalecimiento de la gestión de los gobiernos subnacionales chilenos en Educación Desafios-chave do fortalecimento da gestão dos governos subnacionais chilenos na educação Key challenges in the strengthening of management of Chilean subnational governments in education

    Directory of Open Access Journals (Sweden)

    Sebastián Donoso Díaz

    2006-09-01

    Full Text Available Chile necesita profundizar la gestión de los gobiernos subnacionales en educación como una medida estratégica para su desarrollo. Aunque el diagnósticos obre la materia concita apoyo casi unánime, reconociéndose la necesidad de emprender decididamente esta tarea, no se ha avanzado con la velocidad y profundidad requerida, producto de lo cual, los logros en este campo son menores de lo esperado, materia que se constituye en uno de los desafíos principales, permanentes y más relevantes que es la potenciación de la capacidad de gestión de los gobiernos subnacionales. El trabajo revisa la noción del Estado y del Gobierno aplicada en el caso chileno, por cuanto los procesos de descentralización, constituyen el marco en el cual se inscriben los desafíos de gestión de los gobiernos subnacionales. Más adelante se establecen algunos criterios de reforma en la gestión del Estado, para avanzar hacia la relación Gobiernos subnacionales y el desarrollo de la educación, aspecto que en lo medular analiza resultados de la reforma educativa chilena y los procesos de gestión del gobierno nacional y subnacionales, identificando aquellos aspectos que requieren de una revisión más detenida, en materias como las políticas de financiamiento del sistema educativo, los resultados en materia de calidad y las dificultades de los procesos de gestión en el actual contexto legal. Finalmente se refuerza el rol de la educación pública como opción de desarrollo democrático, en una visión de liderazgo convocante de los otros agentes que participan en el campo educacional, y con un claro sentido de generador de una identidad local.O Chile precisa aprofundar a gestão dos governos subnacionais em educação como uma medida estratégica para o seu desenvolvimento. Embora os diagnósticos sobre a matéria reconheçam a necessidade de se empreender esta tarefa, não se tem avançado com a velocidade e a profundidade requerida, cujos ganhos neste campo s

  11. El liderazgo político chileno: los procesos de generación, desarrollo y recambio

    Directory of Open Access Journals (Sweden)

    Tatiana Herrera Formas

    2005-12-01

    Full Text Available El trabajo que se presenta a continuación, muestra los principales hallazgos y conclusiones que fueron logrados a partir del proyecto de investigación “La Capacidad de Renovación de los Liderazgos Políticos Chilenos: los procesos de generación, desarrollo y recambio”. Este proyecto fue financiado por la Universidad Central y patrocinado por la Facultad de Ciencias Políticas y Administración Pública de la misma casa de estudios, el que será prontamente publicado para el conocimiento de la comunidad académica y el público en general. En particular el presente trabajo se concentra, en elaborar un análisis transversal del liderazgo en cada uno de los denominados "partidos políticos relevantes", reconociendo así el liderazgo político como un fenómeno, un proceso y un símbolo político, y estableciendo la diferencia entre el liderazgo político formal y el no- formal.

  12. Rebeldía en Calama: desafío al orden centralista chileno en un contexto de boom minero

    Directory of Open Access Journals (Sweden)

    Francesco Emmanuel Penaglia Vásquez

    2014-01-01

    Full Text Available En el año 2011, l as protestas en la ciudad minera de Calama marcaron un hito en la historia de los movimientos chilenos de protesta te rritorial. A l exigir autonomía, el 5% de las u tilidades generadas por el cobre (la recuperación de los royalties regionales alcanzados entre 1955 y 1973 luego derogadas en la dictadura militar, y la nacionalización de los recursos, e l movimiento social de Calama se diferencia de otras acciones colect ivas locales y regionales ligadas a fenómenos de representación contenciosa y nimby (no en mi patio trasero ; todas ellas acciones motivadas por razones económicas puntuales, en contra de las externalidades negativas ambientales o construidas sobre el peti cionismo al Estado. El presente artículo es un estudio de casos sobre el movimiento de Calama en el que se reflexiona en torno a tres elementos: la presencia de un liderazgo personalista; la existencia de dos identidades históricas : minera y atacameña; y e l desarrollo de mecanismos de agregación y solidaridad.

  13. Anti-TNF-α and hydralazine drug-induced lupus*

    Science.gov (United States)

    Quaresma, Maria Victória; Bernardes Filho, Fred; de Oliveira, Fernanda Brandão; Pockstaller, Mercedes Prates; Dias, Maria Fernanda Reis Gavazzoni; Azulay, David Rubem

    2015-01-01

    Drug-induced lupus is a rare drug reaction featuring the same symptoms as idiopathic lupus erythematosus. Recently, with the introduction of new medicines in clinical practice, an increase in the number of illness-triggering implicated drugs has been reported, with special emphasis on anti-TNF-α drugs. In the up-to-date list, almost one hundred medications have been associated with the occurrence of drug-induced lupus. The authors present two case reports of the illness induced respectively by hydralazine and infliximab, addressing the clinical and laboratorial characteristics, diagnosis, and treatment. PMID:26312694

  14. Anti-TNF-α and hydralazine drug-induced lupus.

    Science.gov (United States)

    Quaresma, Maria Victória; Bernardes Filho, Fred; Oliveira, Fernanda Brandão de; Pockstaller, Mercedes Prates; Dias, Maria Fernanda Reis Gavazzoni; Azulay, David Rubem

    2015-01-01

    Drug-induced lupus is a rare drug reaction featuring the same symptoms as idiopathic lupus erythematosus. Recently, with the introduction of new medicines in clinical practice, an increase in the number of illness-triggering implicated drugs has been reported, with special emphasis on anti-TNF-α drugs. In the up-to-date list, almost one hundred medications have been associated with the occurrence of drug-induced lupus. The authors present two case reports of the illness induced respectively by hydralazine and infliximab, addressing the clinical and laboratorial characteristics, diagnosis, and treatment. PMID:26312694

  15. Juvenile systemic lupus erythematosus onset patterns in Vietnamese children

    DEFF Research Database (Denmark)

    Dung, Nguyen Thi Ngoc; Loan, Huynh Thoai; Nielsen, Susan;

    2013-01-01

    have systemic lupus erythematosus (f/m = 4/1) were referred to the Ho Chi Minh City Children's Hospital No.1 during a 12-month period in 2009. RESULTS: The mean age at diagnosis was 12.8 years (SD = 2.5). Thirty-seven (82%) fulfilled criteria for lupus nephritis (LN). At diagnosis, impressively high...... No. 1 during a16 month period from 2008-2009. These patients had a strikingly high prevalence of Coombs positive anaemia, a high prevalence of lupus nephritis, and very high SLEDAI and ECLAM scores at the time of diagnosis. While there may be referral biases, our Vietnamese SLE patients appear to...

  16. Anti-C1q antibodies in systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Orbai, A-M; Truedsson, L; Sturfelt, G;

    2015-01-01

    OBJECTIVE: Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study. METHODS: Information...... serologies. Anti-C1q in combination with anti-dsDNA and low complement was the strongest serological association with renal involvement. These data support the usefulness of anti-C1q in SLE, especially in lupus nephritis....

  17. Massive intracranial calcifications in a patient with systemic lupus erythematosus

    International Nuclear Information System (INIS)

    Central nervous system involvement is frequently reported in patients with systemic lupus erythematosus. Computed tomography and magnetic resonance imaging studies usually show brain atrophy, cerebral infarction and/or intracranial bleeding. Extensive intracranial calcification in patients with systemic lupus erythematosus is rare. We report a case of a patient with systemic lupus erythematosus who presented with seizures and massive basal ganglia calcification and mild calcifications in the frontal lobes, seen on the brain computed tomography scan. Magnetic resonance imaging showed hyperintensity on FLAIR images and hypointense signals on T2* gradient echo images in the basal ganglia. (author)

  18. Systemic lupus erythematosus and atherosclerosis: Review of the literature.

    Science.gov (United States)

    Frieri, Marianne; Stampfl, Heather

    2016-01-01

    The purpose of this manuscript is to extensively review the literature related to systemic lupus erythematosus and atherosclerosis. The conclusion of this review has covered accelerated atherosclerosis in systemic lupus erythematosus, the role of complement, interferon in premature atherosclerosis, inflammatory mediators such as cytokines, leukocytes, innate and adaptive immunity, hydrolytic enzymes, reactive oxygen species, vascular endothelial growth factor, toll receptors in lupus nephritis, several specific anti-inflammatory pharmacological therapies, and potential prevention strategies for atherothrombotic events, interferons and the inflammasome. It is important for allergist-immunologists, rheumatologists both in academic institutions and in practice to understand this important disorder. PMID:26299985

  19. Systemic lupus erythematosus flare triggered by a spider bite.

    Science.gov (United States)

    Martín Nares, Eduardo; López Iñiguez, Alvaro; Ontiveros Mercado, Heriberto

    2016-01-01

    Systemic lupus erythematosus is a chronic autoimmune disease with a relapsing and remitting course characterized by disease flares. Flares are a major cause of hospitalization, morbidity and mortality in patients with systemic lupus erythematosus. Some triggers for these exacerbations have been identified, including infections, vaccines, pregnancy, environmental factors such as weather, stress and drugs. We report a patient who presented with a lupus flare with predominantly mucocutaneous, serosal and cardiac involvement after being bitten by a spider and we present the possible mechanisms by which the venom elicited such a reaction. To the best of our knowledge, this is the first such case reported in the literature. PMID:26494589

  20. Do we still need renal biopsy in lupus nephritis?

    Science.gov (United States)

    Haładyj, Ewa; Cervera, Ricard

    2016-01-01

    The natural course of systemic lupus erythematosus (SLE) is characterized by periods of disease activity and remissions. Prolonged disease activity results in cumulative organ damage. Lupus nephritis is one of the most common and devastating manifestations of SLE. In the era of changing therapy to less toxic regimens, some authors have stated that if mycophenolate mofetil can be used for the induction and maintenance treatment in all histological classes of lupus nephritis, renal biopsy can be omitted. This article aims to answer the question of what brings the bigger risk: renal biopsy or its abandonment. PMID:27407281

  1. How the chilean teachers see their identity. Cómo ven su identidad los docentes chilenos

    Directory of Open Access Journals (Sweden)

    Camen Sotomayor

    2012-01-01

    Full Text Available The article is centred on a discussion of teachers’ identity perceptions based on a study carried out in Chile with a nationally representative survey of around 1990 primary and secondary teachers, and a set of interviews and focus groups with teachers.  Teacher identity is construed as having a personal element (teachers own definitionsof their role and a social one (what society expects or definesas their role.  From this perspective, the article is centred on teachers reasons for entering the profession and for continuing within it, their degree of motivation and commitment to teaching, the perception they have of their self-efficac, how teacher education and experience have influencedtheir identity constructions, and finallythe tensions that are live between how teachers perceive their identity and the external social definitions about what is central to teaching and teacher identit.El artículo se centra en la discusión sobre identidad de los docentes sobre la base de un estudio realizado en Chile con una muestra representativa nacional de alrededor de 1990 docentes y un conjunto de entrevistas y grupos focales realizados con profesores de educación básica y media.  La identidad docente se entiende compuesta de una vertiente personal (las propias definicionesde los docentes y una vertiente social (el encargo y la visión social de la docencia. Desde esta perspectiva el artículo se centra en las visiones que entregan los docentes sobre por qué eligieron la docencia y siguen en ella, su grado de motivación y compromiso con las tareas docentes, la percepción que tienen acerca de su eficacia,el rol de la formación docente y la experiencia en su configración identitaria, y finalmente,las tensiones vividas entre la identidad percibida y las definicionesexternas sociales sobre lo que se considera central en la tarea docente.

  2. Lupus eritematoso sistémico en ratones MRL lpr/lpm y knockouts del receptor de quimioquina CCR2

    OpenAIRE

    Camarasa Lillo, Natalia

    2009-01-01

    INTRODUCCIÓN El lupus eritematoso sistémico es una enfermedad autoinmune cuya principal manifestación y debut de la enfermedad es la glomerulonefritis mediada por complejos inmunes. Los ratones MRL/MpJ-Fas lpr/J (MRL/lpr) llevan una mutación en el gen Fas de la apoptosis que da lugar a una proliferación de linfocitos autoreactivos y son considerados un modelo de ratón que reproduce muy bien la enfermedad lúpica en el humano, con linfadenopatía asociada a proliferación aberrante de células T,...

  3. Factores de riesgo cardiovascular en estudiantes universitarios chilenos Cardiovascular risk factors in Chilean university students

    OpenAIRE

    María Teresa Chiang-Salgado; Víctor Casanueva-Escobar; Ximena Cid-Cea; Urcesino González-Rubilar; Paola Olate-Mellado; Fabiola Nickel-Paredes; Leandro Revello-Chiang

    1999-01-01

    OBJETIVO: Evaluar la prevalencia de factores de riesgo cardiovascular en universitarios asintomáticos de ambos sexos, de entre 18 y 25 años de edad. MATERIAL Y MÉTODOS: La muestra quedó integrada por 1 301 estudiantes. En una submuestra de 293 sujetos se midieron lípidos séricos, con un analizador químico Hitachi 717. La obesidad se estimó considerando el índice de masa corporal (IMC); el antecedente familiar de infarto, así como el consumo de cigarrillos y el nivel de actividad física se det...

  4. MECANISMOS DE PROTECCIÓN DE LOS TENEDORES DE BONOS EN EL MERCADO DE VALORES CHILENO

    OpenAIRE

    Jaime Ramiro Gallegos Zúñiga

    2013-01-01

    El presente informe busca exponer el régimen general que regula la emisión de bonos en Chile, presentando también algunas breves similitudes y diferencias con algunos aspectos del Derecho comparado. Una segunda parte de este estudio se centrará en los particulares mecanismos de defensa de los tenedores de bonos, frente a los demás inversionistas, que les posiciona como sujetos pri - vilegiados dentro del ordenamiento jurídico nacional, dada la relevancia que cobra el correc - to funcionamient...

  5. EL DISCURSO DE LA VIOLENCIA EN EL MOVIMIENTO ANARQUISTA CHILENO (1890-1910)

    OpenAIRE

    Igor Goicovic Donoso

    2011-01-01

    Normalmente se vincula al anarquismo con un modo de vida sin orden, sin organización. Mecánicamente, se lo asocia al caos. Pero los propios pensadores anarquistas se encargaron de desmentir sistemáticamente esta visión tendenciosa y estrecha del pensamiento libertario. La contradicción fundamental denunciada por la teoría anarquista se encuentra en la tendencia natural de la humanidad a la plena libertad y en las compulsiones físicas, económicas e intelectuales que alienan al ser huma...

  6. Prevalencia de gingivitis y factores asociados en niños chilenos de cuatro años Prevalence of gingivitis and associated factors in 4 year-old Chilean children

    Directory of Open Access Journals (Sweden)

    C. Zaror Sánchez

    2012-02-01

    Full Text Available Objetivos: Determinar la prevalencia y distribución de gingivitis y su relación con factores socioeconómicos, biológicos y locales en niños chilenos de 4 años. Metodología: Se realizó un estudio transversal enpreescolares de 4 años que acuden al Hospital de Calbuco, Región de Los Lagos, Chile. La muestra consistió en 102 niños/niñas de 4 años. Un examinador, previamente calibrado, realizó examen odontológico, determinando presencia de placa bacteriana visible, caries dental y sangramiento gingival. Resultados: Los resultados demostraron una prevalencia del 93,1% gingivitis, siendo los sextantes IV y VI los más afectados, con un 90 y 92% de prevalencia respectivamente. Al realizar el análisis de la correlación de gingivitis con otros factores, resultó una correlación positiva con caries y con el nivel de placa bacteriana, por sextante. No hubo correlaciones significativas con género, maloclusión, frecuencia de cepillado y responsable del cepillado. Conclusión: La alta prevalencia encontrada, los sextantes más afectadas y la escasa relación con datos de la anamnesis del niño/niña, deben ser consideradas en la educación que se le entrega al adulto responsable del cepillado, particularmente en la población de nivel socioeconómico bajo, quienes son más susceptible a las enfermedades bucales.Objective: To determine the prevalence and distribution of gingivitis and its relation with socioeconomic, biological and local factors in Chilean children of 4 years-old. Methodology: A cross-sectional study was performed in pre-school children of 4 years old attended in Calbuco Hospital, Los Lagos Region, Chile. The sample consisted of 102 children of 4 years-old. An examiner, previously calibrated, realized clinical examination determining presence of visible plaque, dental decay and gingival bleeding. Results: The prevalence of gingivitis was 93,1%, being the sextants IV and IV the most affected, with a 90% and 92% of prevalence

  7. Targeted therapies in systemic lupus erythematosus.

    Science.gov (United States)

    Grech, P; Khamashta, Ma

    2013-09-01

    Systemic lupus erythematosus (SLE) is a chronic, multisystem disorder characterised by loss of tolerance to endogenous nuclear antigens and autoantibody formation. Recent insight into the immunopathogenesis of lupus has provided the foundation for a novel class of agents which target specific, dysregulated components of the immune system. Efforts have focused predominantly on B-cell depleting therapies, of which belimumab was the first to demonstrate success in phase III studies and thus receive marketing authorisation. Off-label prescribing of rituximab in refractory cases is common and supported by uncontrolled studies, which suggest a favourable risk:benefit profile. However, two placebo-controlled trials failed to show benefit, possibly because of inappropriate patient selection and other aspects of trial methodology. Inhibition of dysregulated co-stimulatory signals and cytokines are other therapeutic strategies currently under investigation. Some candidate drugs failed to meet primary endpoints in early-phase clinical trials, yet demonstrated clinical benefit when alternative assessment criteria were applied or specific patient sub-groups analysed. Well-designed studies of greater size and duration are needed to clarify the therapeutic utility of these agents. Future immunomodulatory strategies targeting interferon-alpha, T cells, oxidative stress and epigenetic abnormalities may reduce multisystem disease activity and prolong survival in this complex and heterogeneic disease. PMID:23963429

  8. CT findings at lupus mesenteric vasculitis

    International Nuclear Information System (INIS)

    Purpose: To describe the spectrum of early CT findings of lupus mesenteric vasculitis (LMV) and to assess the utility of CT in the management of this uncommon entity. Methods: Abdominal CT was performed within 1-4 days (average 2.2 days) of the onset of severe abdominal pain and tenderness in 15 women with systemic lupus erythematosus. Prompt high-dose i.v. corticosteroid in 11 patients after the CT diagnosis of LMV was made. CT was performed after abdominal symptoms subsided. Results: Eleven cases revealed CT features suggestive of LMV including conspicuous prominence of mesentric vessels with palisade pattern or comb-like appearance (CT comb sign) supplying focal or diffuse dilated bowel loops (n=11), ascites with slightly increased peritoneal enhancement (n=11), small bowel wall thickening (n=10) with double halo or target sign (n=8). Follow-up CT before high-dose steroid therapy revealed complete or marked resolution of the abnormal CT findings. Conclusion: CT is helpful for confirming the diagnosis of LMV, especially the comb sign which may be an early sign. Bowel ischemia due to LMV is less ominous than previously expected, and the abnormal CT findings were reversible when early diagnosis and prompt i.v. steroid therapy could be achieved. (orig.)

  9. IgA Nephropathy: A Rare Lesion in Renal Biopsy in Systemic Lupus Erythematosus: Case Reports and Review of Literature

    OpenAIRE

    Gürsel YILDIZ; Emre ÇİÇEKLİ; Kayataş, Mansur; Yilmaz, Abdulkerim; Ferhan CANDAN

    2013-01-01

    Lupus nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE). Lupus nephritis is a frequent complication of SLE that increases mortality and morbidity. Minimal glomerular lesions, mesangial proliferative, focal proliferative, membranous and diffuse glomerulonephritis can be seen in renal biopsies of patients with lupus nephritis. It has been reported that non-lupus nephritis can also rarely occur in SLE. While non-lupus nephritis cases usually manifest as foca...

  10. Sostenibilidad urbana. Tomé: Una propuesta para evaluar los planes reguladores chilenos

    Directory of Open Access Journals (Sweden)

    Carolina Rojas Quezada

    2015-03-01

    Full Text Available Este artículo valora la sostenibilidad en la planificación urbana por medio del diseño de un sistema de indicadores, que surgen de la identificación de los atributos del Planeamiento Urbano Sostenible. Los indicadores se ensayan en el modelo de ocupación del suelo propuesto y establecido en el instrumento de planificación territorial denominado "Plan Regulador Comunal". El estudio se aplica en la localidad de Tomé, ubicada en la VIII Región del Bio Bío de Chile. La obtención de los indicadores de sostenibilidad urbana se desarrolla a partir del uso de las herramientas de Sistemas de Información Geográfica ó SIG. El planeamiento urbano propuesto se evalúa con un sistema de indicadores basados en 3 componentes territoriales que se procesan en la zonficación del suelo urbano propuesto y que son, la distribución de usos y estructura fisica, el consumo de Suelo y la calidad ambiental. El método combina el analisis bibliográfico, con la aplicación de análisis espacial y geoprocesamiento en SIG. Los resultados se aproximan a valorar la sostenibilidad del modelo territorial propuesto.

  11. Massive intracranial calcifications in a patient with systemic lupus erythematosus; Calcificacoes intracranianas macicas em um paciente com lupus eritematoso sistemico

    Energy Technology Data Exchange (ETDEWEB)

    Gasparetto, Emerson L.; Carvalho Neto, Arnolfo de [Parana Univ., Curitiba, PR (Brazil). Dept. de Clinica Medica. Servico de Radiologia Medica]. E-mail: gasparetto@hotmail.com; Ono, Sergio E. [Parana Univ., Curitiba, PR (Brazil). Faculdade de Medicina

    2004-12-01

    Central nervous system involvement is frequently reported in patients with systemic lupus erythematosus. Computed tomography and magnetic resonance imaging studies usually show brain atrophy, cerebral infarction and/or intracranial bleeding. Extensive intracranial calcification in patients with systemic lupus erythematosus is rare. We report a case of a patient with systemic lupus erythematosus who presented with seizures and massive basal ganglia calcification and mild calcifications in the frontal lobes, seen on the brain computed tomography scan. Magnetic resonance imaging showed hyperintensity on FLAIR images and hypointense signals on T2{sup *} gradient echo images in the basal ganglia. (author)

  12. Occult systemic lupus erythematosus with active lupus nephritis presenting as Libman-Sacks endocarditis

    Directory of Open Access Journals (Sweden)

    Pankajkumar Ashok Kasar

    2012-01-01

    Full Text Available The diagnosis of systemic lupus erythematosus (SLE depends on clinical evidence of renal, rheumatologic, cutaneous, and neurologic involvement, supported by serological markers. A previously healthy 14-year-old girl presented with Libman-Sacks endocarditis involving the aortic valve as the first manifestation of SLE. Even though she did not satisfy the American College of Rheumatology criteria for diagnosing SLE, she had anemia, proteinuria, elevated erythrocyte sedimentation rate, low complement 4 (C4 levels, and strongly positive antinuclear antibody titer. A renal biopsy showed stage IV lupus nephritis. Treatment was initiated with immunosuppressants and steroids. This type of presentation may be misdiagnosed as infective endocarditis missing the underlying collagen vascular disease.

  13. Cohort profile: systemic lupus erythematosus in Sweden: the Swedish Lupus Linkage (SLINK) cohort

    OpenAIRE

    Arkema, Elizabeth V; Simard, Julia F

    2015-01-01

    Purpose A cohort of individuals with systemic lupus erythematosus (SLE) was identified through linkage of several national registers to investigate important epidemiological questions using not only population-based data to minimise selection bias, but also to identify matched comparators from the general population to serve as controls. This cohort was established to overcome the general dearth of data in SLE epidemiology. Participants All individuals registered in Sweden with a personal ide...

  14. Predicción de la masa muscular apendicular esquelética basado en mediciones antropométricas en Adultos Mayores Chilenos

    OpenAIRE

    Lydia Lera; Cecilia Albala; Bárbara Ángel; Hugo Sánchez; Yaisy Picrin; María José Hormazabal; Andrea Quiero

    2014-01-01

    Objetivos: Desarrollar un modelo antropométrico de predicción de masa muscular apendicular esquelética (MMAE), en adultos mayores chilenos. Métodos: La muestra estudiada corresponde a 616 adultos > 60 años (69,9 ± 5,2 años), 64,6% mujeres, autovalentes, viviendo en la comunidad en Santiago, Chile, participantes del estudio ALEXANDROS. Se efectuaron mediciones antropométricas, dinamometría de mano, pruebas de movilidad y densitometría ósea (DEXA). Mediante modelos de regresión lineal paso a pa...

  15. Patologías dentales en incisivos, caninos y primer premolar en caballos chilenos adultos Dental pathologies in incisors, canines and first premolar in adult Chilean horses

    OpenAIRE

    Muñoz, L.; F Vidal; O Sepúlveda; O Ortiz; C Rehhof

    2010-01-01

    Las patologías dentales han ido tomando mayor relevancia clínico veterinaria, aumentando el número de consultas, tratamientos y procedimientos preventivos. En caballos chilenos, la información existente de patologías dentales es nula, por lo que se hace primordial la investigación y recolección de datos en esta raza. Se analizaron 100 caballos pertenecientes a la Asociación de Rodeo Concepción, entre los meses de junio y septiembre del año 2007. Los materiales que se utilizaron fueron puro, l...

  16. Virus de la Enfermedad Infecciosa de la Bolsa de Fabricio: Relaciones antigénicas de aislados cubanos y chilenos Infectious Bursal Disease Virus: antigenic interrelationships between

    OpenAIRE

    J Noda; J ULLOA; C L Perera; G Jara; Cuello, S.; E. Rodríguez

    2005-01-01

    La Enfermedad Infecciosa de la Bolsa (EIB) sigue afectando la industria avícola por la aparición de variantes patogénicas y antigénicas del virus, originadas en la permanente evolución del virus producto de la presión inmunológica por el uso intensivo de vacunas. La caracterización antigénica de los virus de campo resulta esencial para la aplicación de vacunas más adecuadas en el control de la enfermedad. En este trabajo se determinaron las relaciones antigénicas de aislados cubanos y chileno...

  17. Contraste empírico del CAPM en el mercado accionario chileno Empirical test of the CAPM in the Chilean stock market

    OpenAIRE

    Carlos A Díaz Contreras; Freddy H Higuera Cartes

    2012-01-01

    El modelo de valoración de activos de capital (Capital Asset Pricing Model - CAPM) es uno de los modelos más utilizados en la práctica para determinar el premio por riesgo de un activo individual o cartera. El presente trabajo realiza un contraste empírico del CAPM en el mercado accionario chileno, empleando las metodologías de serie temporal y de eficiencia media-varianza, basada en la estimación por el método generalizado de momentos (MGM). El contraste se llevó a cabo usando rentabilidades...

  18. Monumento Natural El Morado (Andes Centrales Chilenos). Análisis del medio biofísico, paisaje y propuesta de actuación, El

    OpenAIRE

    Infante Fabres, Nelson Osvaldo

    2009-01-01

    [spa] Esta tesis doctoral centra su interés en el estudio geográfico de la cuenca hidrográfica del estero Morales, afluente del río Volcán, en los Andes centrales chilenos. Para ello analiza el medio biofísico, describe, analiza y clasifica el paisaje, realiza una serie de propuestas para su mejor y adecuada gestión. Se trata de una investigación de base que aporta datos de interés relativo al funcionamiento del sistema natural del valle, catalogado como figura de protección por parte del Gob...

  19. Discoid lupus erythematosus exacerbated by X-ray irradiation

    International Nuclear Information System (INIS)

    The authors describe a patient, previously known to have discoid lupus erythematosus (LE) developing a LE rash in the precise distribution of radiation therapy given for the treatment of a bronchogenic neoplasm. (author)

  20. Intravenous Immunoglobulin in the Management of Lupus Nephritis

    Directory of Open Access Journals (Sweden)

    Scott E. Wenderfer

    2012-01-01

    Full Text Available The occurrence of nephritis in patients with systemic lupus erythematosus is associated with increased morbidity and mortality. The pathogenesis of lupus nephritis is complex, involving innate and adaptive cellular and humoral immune responses. Autoantibodies in particular have been shown to be critical in the initiation and progression of renal injury, via interactions with both Fc-receptors and complement. One approach in the management of patients with lupus nephritis has been the use of intravenous immunoglobulin. This therapy has shown benefit in the setting of many forms of autoantibody-mediated injury; however, the mechanisms of efficacy are not fully understood. In this paper, the data supporting the use of immunoglobulin therapy in lupus nephritis will be evaluated. In addition, the potential mechanisms of action will be discussed with respect to the known involvement of complement and Fc-receptors in the kidney parenchyma. Results are provocative and warrant additional clinical trials.