Reflexiones sobre poderes femeninos, cuerpos y sensibilidades en un hogar chileno

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María Eugenia Albornoz Vásquez

2009-11-01

Full Text Available Esta historia, co-escrita por su director junto a Pedro Peirano, guionista de “31 minutos”, muestra un momento crucial de Raquel, magistralmente interpretada por Catalina Saavedra, una nana de Santiago, que lleva trabajando y viviendo más de la mitad de su vida en casa de sus “patrones”, una “mujer empleada” que no tiene otro horizonte que ese lugar y esa rutina. También retrata agudamente un tipo de hogar chileno, se ríe con cariño de las heridas, las frustraciones, las ridiculeces y los er...

Aporte de vitaminas y minerales por grupo de alimentos en estudiantes universitarios chilenos

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Samuel Durán Agüero; Susanne Reyes García; María Cristina Gaete

2013-01-01

Introducción: La etapa universitaria es un proceso en el cual las personas pasan por periodos prolongados de inactividad física y horarios irregulares de comidas, lo que conlleva al incremento en el consumo de alimentos procesados y de comida rápida. Objetivo: Fue determinar el aporte vitaminas y minerales por grupo de alimentos en la alimentación de estudiantes universitarios. Métodos: Se trabajó con una muestra de 654 estudiantes universitarios chilenos (18-24 años, 54% mujeres), a quienes ...

Embarazo y lupus eritematoso sistémico

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Rita Campillo Motilva

2001-12-01

Full Text Available El lupus eritematoso sistémico es una enfermedad autoinmune y sistémica, que se presenta con frecuencia en mujeres jóvenes y por tanto en su etapa reproductiva; se asocia a un alto riesgo de morbilidad y mortalidad perinatal. Las complicaciones más frecuentes son los abortos, la muerte fetal, la prematurez, el retardo del crecimiento intrauterino y el lupus neonatal. Los anticuerpos potencialmente perjudiciales sobre la gestación son los antifosfolípidos (anticoagulante lúpico y anticardiolipinas y anti-Ro y anti-La. Con un correcto asesoramiento preconcepcional y un adecuado seguimiento durante el embarazo y el puerperio, se puede encarar con una gran probabilidad de éxito la maternidad en estas pacientes.Systemic lupus erythematosus is an autoimmune and systemic disease that appears frequently in young women and, therefore, during the reproductive stage. It is associated with a high risk of morbidity and perinatal mortality. The most common complications are abortions, fetal death, prematurity, retarded intrauterine growth and neonatal lupus.The potentially harmful antibodies for gestation are the antiphospholipids (lupus anticoagulant and anticardiolipins and anti-Ro and anti-La. With a correct preconceptional counselling and an adequate follow-up during pregnancy and puerperium, maternity may be faced with great probabilities of success in these patients.

Factores de riesgo relacionados con lupus eritematoso sistémico en población mexicana

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Zonana-Nacach Abraham

2002-01-01

Full Text Available Objetivo. Evaluar los factores de riesgo asociados con el desarrollo de lupus eritematoso sistémico en población mexicana. Material y métodos. Estudio de casos y controles, efectuado en junio de 1996 en el Departamento de Reumatología del Hospital de Especialidades del Centro Médico Nacional Siglo XXI (HE CMN, del Instituto Mexicano del Seguro Social, de la Ciudad de México. Se estudiaron 130 pacientes (casos que presentaban cuatro o más criterios de clasificación de lupus eritematoso sistémico (LES y con una evolución de la enfermedad menor de cinco años. Los controles fueron pacientes hospitalizados por enfermedades agudas no autoinmunes. Fueron pareados 1:1 por edad y sexo; ambos grupos se evaluaron a través de una entrevista directa y la aplicación de un cuestionario estructurado. Se estudiaron los siguientes factores de riesgo: genéticos (historia familiar de LES o enfermedad de tejido conjuntivo, sociodemográficos (raza, lugar de residencia, educación, ingreso mensual; hormonales (anticonceptivos orales, terapia hormonal de remplazo y ginecobstétricos; ambientales (productos para el cabello, cohabitación con perros, infecciones, alergias. El análisis estadístico fue hecho con razón de momios (RM IC 95% y regresión logística. Resultados. El análisis estadístico multivariado mostró asociación con el antecedente familiar de LES (RM 4.2, IC 95% 1.17-15.2 u otra ETC (RM 2.6, IC 95% 1.15-4.5, uso de anticonceptivos orales por más de un año (RM 2.1, IC 95% 1.13-4.3, faringoamigdalitis de repetición (RM 2.1, IC 95% 1.18 - 3.6 y fármacos (RM 5.0, IC 95% 1.62 - 21.6. No hubo relación con factores socieconómicos, el uso de productos para el cabello, con asma o con antecedentes alérgicos. Conclusiones. Factores genéticos como el antecedente heredo-familiar de LES o enfermedad de tejido conjuntivo en familiares de primer grado continúan siendo factores importantes en el desarrollo de LES. Otros factores de riesgo

LUPUS ERITEMATOSO CUTÁNEO: ANÁLISIS CLÍNICOS Y DE LABORATORIO

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Priscila Maria da Silva Gomes

2015-07-01

Full Text Available El lupus eritematoso (LE se incluye entre las llamadas enfermedades del tejido conectivo y se divide en una forma sistémica lupus eritematoso sistémico (LES y una forma eritematoso piel lupus cutáneo (LEC. La LE es una enfermedad autoinmune heterogénea y multisistémica caracterizada por la producción de anticuerpos que combaten su propio cuerpo en lugar de antígenos que luchan. El lupus es una enfermedad con mayor frecuencia entre las edades de 20 a 50 años, que afecta a más mujeres que hombres que implican, en la mayoría de los casos, los pacientes con antecedentes familiares de lupus y otras enfermedades autoinmunes.

Características Antropométricas de Triatletas amateur Chilenos: Un estudio piloto

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Jorge A Sanhueza; Carlos Bahamondes-Avila; Claudio Hernández-Mosqueira; Daniela Abarzua-Mandiola; Tomás Zambrano; Luis A Salazar

2017-01-01

Introducción: Las características antropométricas de los triatletas son consideradas un importante factor condicionante del rendimiento deportivo. El objetivo del presente estudio fue caracterizar el perfil antropométrico de un grupo de triatletas amateur chilenos participantes de la prueba de medio Ironman de Pucón del año 2014 según categoría. Material y Métodos: Fueron evaluados 37 triatletas varones con un promedio de edad de 29,0 años y un peso de 74,3kg. Se midieron 25 variables ant...

Significaciones de la democracia en los mensajes presidenciales chilenos: 1990-2014

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Carlos Salvatore Durán Migliardi

2017-12-01

Full Text Available Este artículo se propone describir las significaciones que asume la democracia en el primero de los mensajes ante el Congreso Pleno emitido por cada uno de los presidentes de Chile durante el periodo 1990-2014. Junto con relevar el lugar del discurso en las dinámicas políticas, se pretende dar cuenta de las relaciones de continuidad y ruptura en torno a las significaciones hegemónicas que, en relación a este significante clave del lenguaje político, han circulado en el campo político chileno desde el retorno a la democracia en 1990.

LAS METAS MÚLTIPLES: ANÁLISIS PREDICTIVO DEL RENDIMIENTO ACADÉMICO EN ESTUDIANTES CHILENOS

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Leandro Navas Martínez; José Antonio Soriano Llorca; Francisco Pablo Holgado Tello; Irene Jover Mira

2016-01-01

Este estudio parte de la perspectiva que analiza el contenido de las metas en contextos académicos para explicar la motivación para los estudios. El objeti - vo es analizar la estructura que presentan las metas múltiples en estudiantes chilenos y sus relaciones con el rendimiento académico. Esto implica valorar las cualidades psicométricas del Cuestionario de Metas y valorar la contri - bución de las diferentes metas como variables predictoras del rendimiento académico. Participan 1773 es...

Personalidad eficaz e inteligencia emocional en contextos universitarios chilenos

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Tapia Allende, Roxana

2017-01-01

La investigación da cuenta sobre la relación empírica que existe entre los constructos de Personalidad Eficaz e Inteligencia / Competencia Emocional Intrapersonal e Interpersonal en contextos universitarios chilenos. Para ello, los objetivos propuestos son: establecer la relación empírica existente entre los constructos de Personalidad Eficaz y las Competencias Emocionales Intrapersonales e Interpersonales en contextos universitarios chilenos; establecer los tipos de personalidad eficaz y l...

Calidad de vida, ansiedad, depresión y optimismo disposicional en pacientes con lupus eritematoso sistémico

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Yenier Enrique Perez Mesa

2014-01-01

Full Text Available El presente artículo de investigación caracteriza la relación entre Calidad de Vida Relacionada con la Salud (CVRS y la ansiedad, depresión y optimismo disposicional, en pacientes con Lupus Eritematoso Sistémico (LES, que se hallan en estado de remisión y de actividad lúpica. Se realizó un estudio descriptivo-correlacional de corte transversal, sustentado en el paradigma integrativo de la investigación. La muestra estuvo formada por 41 pacientes y los resultados demuestran afectaciones en la CVRS. Los pacientes presentan un nivel moderado de ansiedad en sus dimensiones estado-rasgo, así como en depresión-rasgo, mientras que la depresión situacional resultó elevada. Poseen también un alto nivel de optimismo disposicional, evidenciándose este como una estrategia de afrontamiento. Se encontraron diferencias significativas en la comparación de subgrupos de pacientes según se hallaran o no en estado de remisión y actividad de la dolencia. Abstract This research paper focuses on the relationship between Health Related Quality of Life (HRQL, anxiety, depression and dispositional optimism in patients with Systemic Lupus Erythematosus (SLE, and who have been referred to as having Lupus characteristics. A descriptive-correlational cross sectional study, based on the integrated research paradigm was conducted in which 41 patients were sampled and the results showed an impact on Health Related Quality of Life (HRQL. Patients showed a moderate level of anxiety and depression by trait, in contrast with situational depression which was high. Patients also show high level of dispositional optimism, as a coping strategy. Comparing subgroups of patients undergoing or not experiencing remission of the disease, significant differences were found.

Systemic Lupus Erythematosus (Lupus)

Science.gov (United States)

... Lupus) English Español 繁體中文 한국어 tiếng Việt Systemic Lupus Erythematosus (Lupus) Basics In-Depth Download Download EPUB Download PDF What is it? Points To Remember About Systemic Lupus Erythematosus (Lupus) Lupus can affect many body parts, ...

UN CINEASTA CHILENO. KUZMANICH Y EL CINE DE LA VIOLENCIA EN COLOMBIA

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Angélica María Mateus Mora

2007-07-01

Full Text Available La autora presenta un análisis del film Canaguaro (1981 del chileno Dunav Kuzmanich.Se trata de una realización cinematográfica colombiana profundamenteinnovadora en su constitución, en cuanto desarrolla una construcción colectiva e imaginaria de la violencia. En este contexto de la violencia sociopolítica de la guerrilla, el protagonista no es necesariamente un personaje, sino que es el pueblo, algo que es interesante pues conecta el cine latinoamericano con una larga reflexión ensayística. Este film, muestra un cine que asume una posición crítica frente a la historia colombiana oficial, con la clara intención de develar episodios ocultos de esta historia, en especial de una etapa particular, donde el cine logra, incluso más que la misma historiografía, representar la complejidad histórica, analizar los procesos internos y proyectar esa realidad histórica al presente.

Actitudes hacia la inmigración de los estudiantes de psicología chilenos: análisis diferenciales

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Leandro Navas

2013-08-01

Full Text Available El objetivo del estudio fue analizar las actitudes hacia la inmigración de un grupo de estudiantes de psicología chilenos. Participaron 117 sujetos con edades comprendidas entre los 18 y 33 años. Se aplicó la Escala de Actitudes hacia la Inmigración (León, Mira y Gómez, 2007. Los resultados indicaron que el instrumento seleccionado presenta coeficientes de fiabilidad aceptables y que las actitudes de los sujetos muestran una tendencia favorable, excepto en la variable distancia social positiva. No obstante, un número importante de sujetos mostró una actitud intermedia, la cual se podría relacionar con un prejuicio sutil. Existen diferencias en las actitudes que favorecen a las mujeres y a los individuos que se han relacionado con personas inmigrantes.

Estatus de selenio en equinos Criollo-Chileno a pastoreo y su respuesta a la suplementación

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Macarena Rioseco H.

2013-11-01

Full Text Available Objetivo. Dos experimentos se realizaron para determinar el estatus de selenio en equinos Criollo-Chileno a pastoreo y, evaluar la respuesta a la suplementación con Na2SeO3. Materiales y métodos. Exp.1A caballos pertenecientes a 10 criaderos del sur de Chile se les determinó la actividad sanguínea de glutatión peroxidasa (GPx, EC.1.11.1.9 (AcGPx. Los animales pertenecieron a 3 grupos, pastoreo de otoño (PO, n=40, pastoreo de otoño y suplementados con avena (PO+A, n=47, y, pastoreo de primavera (PP, n=41. Exp2Se utilizaron equinos con carencia de selenio, distribuidos en tres grupos: G1, n=7, tratado con Na2SeO3 el día 0 (Se= 0.05 mg/kg pv, im; G2, n=8, suplementado con Na2SeO3, los días 0 y 15 y GC, n=8, control. La AcGPx se determinó al día 0, 30 y 120. Resultados. La mediana (Me de la AcGPx en todos los grupos fue menor al límite adecuado (>130 U/gHb, mayor en PO+A (Me=92, P25%=47, P75%=129 U/gHb y PP (Me=85, P25%=45, P75%=114 U/gHb que en PO (Me=35, P25%=20, P75%=85 U/gHb (p<0.05. En el experimento 2 la AcGPx fue similar y menor al adecuado en todos los grupos. La suplementación con Na2SeO3 aumentó (p<0.05 la AcGPx en G1 (121±52 U/gHb y G2 (124±69 U/gHb, sin alcanzar valores adecuados. Conclusiones. Los equinos Criollo-Chileno a pastoreo en el sur de Chile presentan carencia de Se, mayor en otoño que primavera y menor al suplementar con avena. Adicionalmente, la administración parenteral de Na2SeO3 mejora el estatus de Se, pero sin revertir el cuadro carencial.

LOS JÓVENES CHILENOS Y LA RELIGIÓN. UNA MIRADA A PARTIR DE LAS ENCUESTAS NACIONALES DE JUVENTUD.

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Javier Romero

2011-01-01

El presente artículo muestra las tendencias de las principales dimensiones de la religiosidad delos jóvenes chilenos que han sido difundidas en las Encuestas Nacionales de Juventudrealizadas por el Instituto Nacional de la Juventud. Dichas tendencias de cambio son parte delas transformaciones culturales que la sociedad chilena en su conjunto ha experimentado en eltiempo reciente. Los cambios que nuestra sociedad ha vivido también impactan en el campo religioso y susrelaciones con el dinám...

INGESTA DE BEBIDAS AZUCARADAS ANALCOHOLICAS E INDICE DE MASA CORPORAL. UN ESTUDIO EN ESCOLARES CHILENOS

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ARANEDA FLORES, JACQUELINE A.

2013-01-01

Introducción: En las últimas décadas, a nivel mundial, se ha observado un aumento en el consumo de bebidas azucaradas analcohólicas y paralelamente el incremento de peso corporal en niños y adolescentes, situación que ha sido asociada positivamente en diversos estudios. Hipótesis: Existe una relación directa entre el consumo de bebidas azucaradas analcohólicas y el Índice de Masa Corporal en los escolares chilenos entre los 6-18 años de edad. Así a medida que aumenta el cons...

Factores de riesgo relacionados con lupus eritematoso sistémico en población mexicana Risk factors associated with systemic lupus erythematosus in Mexican population

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Abraham Zonana-Nacach

2002-06-01

Full Text Available Objetivo. Evaluar los factores de riesgo asociados con el desarrollo de lupus eritematoso sistémico en población mexicana. Material y métodos. Estudio de casos y controles, efectuado en junio de 1996 en el Departamento de Reumatología del Hospital de Especialidades del Centro Médico Nacional Siglo XXI (HE CMN, del Instituto Mexicano del Seguro Social, de la Ciudad de México. Se estudiaron 130 pacientes (casos que presentaban cuatro o más criterios de clasificación de lupus eritematoso sistémico (LES y con una evolución de la enfermedad menor de cinco años. Los controles fueron pacientes hospitalizados por enfermedades agudas no autoinmunes. Fueron pareados 1:1 por edad y sexo; ambos grupos se evaluaron a través de una entrevista directa y la aplicación de un cuestionario estructurado. Se estudiaron los siguientes factores de riesgo: genéticos (historia familiar de LES o enfermedad de tejido conjuntivo, sociodemográficos (raza, lugar de residencia, educación, ingreso mensual; hormonales (anticonceptivos orales, terapia hormonal de remplazo y ginecobstétricos; ambientales (productos para el cabello, cohabitación con perros, infecciones, alergias. El análisis estadístico fue hecho con razón de momios (RM IC 95% y regresión logística. Resultados. El análisis estadístico multivariado mostró asociación con el antecedente familiar de LES (RM 4.2, IC 95% 1.17-15.2 u otra ETC (RM 2.6, IC 95% 1.15-4.5, uso de anticonceptivos orales por más de un año (RM 2.1, IC 95% 1.13-4.3, faringoamigdalitis de repetición (RM 2.1, IC 95% 1.18 - 3.6 y fármacos (RM 5.0, IC 95% 1.62 - 21.6. No hubo relación con factores socieconómicos, el uso de productos para el cabello, con asma o con antecedentes alérgicos. Conclusiones. Factores genéticos como el antecedente heredo-familiar de LES o enfermedad de tejido conjuntivo en familiares de primer grado continúan siendo factores importantes en el desarrollo de LES. Otros factores de riesgo

CUANDO LAS AFRENTAS SE LAVABAN CON SANGRE: HONOR, MASCULINIDAD Y DUELOS DE ESPADAS EN EL SIGLO XVIII CHILENO

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Verónica Undurraga Schüler

2008-06-01

Full Text Available Este trabajo aborda la relación entre honor y prácticas sociales en el siglo XVIII chileno, analizando la figura de los duelos o expresiones de violencia masculina formalizada. Junto con indagar en los mecanismos restitutorios del honor y su vinculación a los fundamentos de una masculinidad tradicional, reflexiona sobre las gamas de manejo social de dicho valor en el período señalado. Teóricamente se rescatan los aportes de la antropología y se hace un balance del tratamiento historiográfico del problema. Desde los registros judiciales se plantea el carácter transversal del honor en términos sociales y se aborda su "doble naturaleza" en cuanto espacio relacional y ámbito de confrontación de los individuos.This works deals with the relationship between honor and social practices in Chile's eighteenth century and analyzes formal duels or expressions of legalized masculine violence. This article explores various manifestations of the social ways used to deal with honor at that time, together with the inquiries about mechanisms used to restore honor and its links with traditional masculinity. Theoretically, this work rescues contributions made by anthropologists and provides an overview of how honor and masculinity have been examined in the historiography. Starting from judicial records, the article considers the transversal character of honor in social terms and approaches its "double significance" as both a relational space for people and as a sphere for the confrontation of individuals.

¿HACIA DÓNDE VA EL DERECHO SOCIETARIO?: UN ANÁLISIS DESDE EL DERECHO COMPARADO Y UNA PROPUESTA PRELIMINAR PARA EL DERECHO CHILENO

OpenAIRE

Vásquez Palma, M. Fernanda

2015-01-01

El presente artículo efectúa una amplia revisión de las reformas realizadas en el Derecho societario de la Unión Europea con el objetivo de comprender y delimitar las modificaciones efectuadas en los últimos años, junto a sus fundamentos subyacentes. A partir de este estudio nos abocamos, en la segunda parte de este texto, en el análisis de estas materias en el Derecho chileno con el propósito de comenzar a construir una plataforma que nos orientará sobre los aspectos que debemos valorar de l...

Movimiento estudiantil chileno de 2011 y su influencia en las reivindicaciones ciudadanas desde los márgenes regionalistas

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Javier Ramos Galleguillos

2013-06-01

Full Text Available Uno de los conflictos sociales más significativos del año 2011 en Chile, fue el movimiento estudiantil, que en conjunto con diversos actores sociales, promovieron la consigna de una educación pública, democrática y de calidad. Bajo este argumento, la presente ponencia pretende analizar y describir de qué manera el Movimiento Estudiantil chileno iniciado en 2011, gatilla un empoderamiento ciudadano contra el régimen político y económico en favor de un Estado de Bienestar transversal a los distintos sectores sociales. Se indaga además, en las repercusiones que tuvo este Movimiento para la formulación de nuevas demandas desde los márgenes regionalistas, con el fin de interpretar el creciente descontento ciudadano y su necesidad de organización orientado a romper con la brecha de desigualdad existente en Chile.

Diferencias en ansiedad social auto-informada entre estudiantes universitarios chilenos y franceses.

OpenAIRE

Carolina Baeza-Velasco; Caroline Fénétrier; Marie-Christine Gély-Nargeot

2012-01-01

Originales / Original Papers Resumen En este trabajo se comparan las puntuaciones de 85 estudiantes universitarios chilenos y 174 franceses que respondieron a la Escala de Ansiedad Social de Liebowitz (LSAS). Los hombres franceses presentaron puntuaciones significativamente superiores que los hombres chilenos en la LSAS. Ninguna diferencia fue observada entre las mujeres de ambos países. Los resultados se discuten en términos de diferencias culturales tales como el individualismo y el colecti...

Cine chileno e industria… el desafío que falta

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Fernando Véliz M.

2006-01-01

Full Text Available El cine chileno es un campo discursivo de la industria audiovisual aún en proceso de crecimiento. Su historia está cargada de imprecisiones y múltiples inicios que muchas veces quedan truncos; es un cine que se ha comprometido con los problemas sociales, pero que también ha sabido de lejanías y silencios impuestos; es un cine artesanal que aspira a mirar como industrial; es un cine que narra desde el tercer mundo, muchas veces con un 98% de consumo (en sus momentos más fuertes de producción norteamericana; es decir, es un cine que se ha formado en la autogestión absoluta de su capital simbólico. Es un cine que, por medio de libros y películas de culto, está generando una nueva camada de directores, los cuales buscan comprender su rol en esta industria que hoy, ya con el pasar del tiempo, tiene audiencias cautivas. Es un cine que a ratos camina junto al Estado y, en otras ocasiones, es la soledad su compañera de ruta. Es un cine fundado en la creatividad, búsqueda y superación de su oficio, y que poco a poco, comprende que el valor agregado está en sus historias locales.

Asociación entre hábitos alimentarios e índice de masa corporal normal en soldados chilenos

OpenAIRE

Durán-Agüero, Samuel; Maraboli Ulloa, Daniela; Cubillos-Schmied, Gonzalo; Fernández-Frías, Francisco

2016-01-01

Introducción: Se han evaluado los hábitos alimentarios de diversos grupos etarios y oficios, sin embargo, hay poca información de hábitos alimentarios en soldados. El objetivo del presente estudio es asociar hábitos alimentarios con el índice de masa corporal (IMC) normal en soldados chilenos del Regimiento Buín, Chile. Material y Métodos: Se evaluó a 412 soldados, a cada uno se le aplicó una encuesta alimentaria y una evaluación antropométrica para determinar IMC. Se consideró IMC normal cua...

Una nueva estructura de garantías para los bonos chilenos de infraestructura

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Werner Kristjanpoller Rodríguez

2011-12-01

Full Text Available El sistema chileno de concesiones ha sido uno de los fundamentos del desarrollo del país y ha creado una fuerte relación entre el sector público y el sector privado para financiar grandes obras. La reciente crisis financiera destruyó la confianza en las compañías de seguros "monolínea", las cuales aseguran los bonos de infraestructura de Chile aumentando su calificación de riesgo a AAA a nivel internacional. En este contexto es necesario estudiar nuevas estructuras de garantías para estos bonos, en particular para proyectos superiores a 200 millones de dólares. Se proponen dos alternativas: una Sociedad de Garantía y garantías de contratos de concesión con cobertura privada.

Lupus

Science.gov (United States)

What is lupus? Lupus is an autoimmune disease. This means that your immune system attacks healthy cells and tissues by mistake. This can ... vessels, and brain. There are several kinds of lupus Systemic lupus erythematosus (SLE) is the most common ...

LAS METAS MÚLTIPLES: ANÁLISIS PREDICTIVO DEL RENDIMIENTO ACADÉMICO EN ESTUDIANTES CHILENOS

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Leandro Navas Martínez

2016-01-01

Full Text Available Este estudio parte de la perspectiva que analiza el contenido de las metas en contextos académicos para explicar la motivación para los estudios. El objeti - vo es analizar la estructura que presentan las metas múltiples en estudiantes chilenos y sus relaciones con el rendimiento académico. Esto implica valorar las cualidades psicométricas del Cuestionario de Metas y valorar la contri - bución de las diferentes metas como variables predictoras del rendimiento académico. Participan 1773 estudiantes de las regiones centro y sur de Chile en las diferentes etapas del sistema educativo, con edades comprendidas en - tre 11 y 50 años. Se analiza la dimensionalidad del instrumento con análisis factoriales, exploratorio y confirmatorio, y se realiza un análisis de regresión múltiple. Surgen tres tipos de metas (sociales, académicas y de responsabili - dad que explican el 20% de la varianza del rendimiento académico. La mayor contribución para predecir el rendimiento de los estudiantes corresponde a las metas académicas. Se derivan implicaciones prácticas y se sugieren líneas de trabajo para futuras investigaciones.

Manifestaciones pulmonares del Lupus Eritematoso Sistémico Pulmonary manifestations of systemic lupus erithematosus

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José Fernando Molina

1991-03-01

Full Text Available En esta revisión se describen las diversas manifestacionespulmonares del Lupus Eritematoso Sistémico; se Incluyen tanto los cuadrosrelacionados con la enfermedad (pleuritis con o sin derrame, neumonitis lúpicaaguda, enfermedad intersticlaidifusa, hipertensión pulmonar, disfunción diafragmática,atelectasia y hemorragia pulmonar como los asociados a ella (infección, edemapulmonar urémico, embolismo pulmonar, neumotórax, pseudolinfoma y sarcoidosis.Se consideran someramente aspectos clínicos, patológicos, patogénicos,diagnósticos y terapéuticos. En cuanto a los últimos se enfatizan algunasconsideraciones generales de importancia en el manejo de estos pacientes; sonellas: la necesidad de descartar ante todo la posibilidad de un proceso Infecciosoy de emplear antibióticos de amplio espectro hasta excluir1o; la de agotarrecursos hasta establecer un diagnóstico definitivo y la de recurrir a laterapia inmunosupresora una vez excluida la infección O cuando no ha habidorespuesta a los antibióticos adecuados

The various pulmonary manifestations of Systemic Lupus Erythematosus are described in this review; it includes related (pleurisy with/without effusion, acute lupus pneumonitis, diffuse interstitial disease, pulmonary hypertension, diaphragmatic dysfunction, atelectasis, pulmonary hemorrhage as well as associated (infection, uremic pulmonary edema, pulmonary embolism, pneumothorax, pseudolymphoma, sarcoldosis, miscellaneous conditions. Clinical, pathological, pathogenic, diagnostic and therapeutic aspects are con. sidered. Emphasis is done on certain general therapeutic considerations, namely: to rule out the possibillty of an infectious process and use wide-spectrum antibiotics until certainty is acquired that it is not present; to use every available diagnostic resource until a definite diagnosis Is established

Xenofobia y Homofobia como Efectos de la Orientación Política, Religión y Sexo Mediados por Clasismo y Patriocentrismo en Jóvenes Universitarios Chilenos

OpenAIRE

Fuad Hatibovic Díaz; Magdalena Bobowik; Ximena Faúndez Abarca; Juan Sandoval Moya

2017-01-01

La presente investigación examina, en estudiantes universitarios chilenos, la relación entre xenofobia, homofobia y las variables: sexo, religión y orientación política. También se evalúa el papel mediador del clasismo y patriocentrismo en la relación entre las variables sociodemográficas y la xenofobia y homofobia. Se utilizó metodología cuantitativa con diseño descriptivo correlacional. Los participantes fueron 509 estudiantes, con promedio de 20.81 años de edad (dt=2.25). Se utilizó un cue...

A propósito de la Ley de Comunicación en Ecuador : diálogo con Valerio Fuenzalida

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Oquendo Sánchez, Christian

2011-01-01

Diálogo con el comunicólogo chileno, quien aborda el tema de la Ley de Comunicación en Ecuador a partir de la experiencia de las trasnformaciones legales y la vigencia de los medios públicos en Chile. Fuenzalida conoce muy bien ambas realidades y avizora salidas para Ecuador. Diálogo com o especialista em comunicaç?o chilenos que aborda a quest?o da Lei de Comunicaç?o no Equador a partir das transformaç?es da experiência jurídica ea validade dos meios de comunicaç?o públicos no Chile. Fuen...

Anticoagulante lúpico en enfermedades autoinmunes Lupus anticoagulant in autoimmune diseases

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Dunia de la C Castillo González

2004-08-01

Full Text Available El tromboembolismo venoso es una complicación reconocida en diferentes enfermedades autoinmunes. Se ha establecido que la detección del anticoagulante lúpico (AL y posiblemente los anticuerpos anticardiolipina (AAC tipo Ig G en título alto y medio, ayuden a identificar pacientes con riesgo de trombosis. Estudiamos el AL en 81 pacientes con enfermedades autoinmunes: 25 pacientes con lupus eritematoso sistémico (LES, 28 pacientes con púrpura trombocitopénica idiopática (PTI, 15 con anemia hemolítica autoinmune (AHAI y 13 que se incluyeron en el grupo de otras enfermedades, que comprendían vasculitis cutánea de pequeños vasos, enfermedad mixta del tejido conectivo, artritis reumatoidea y esclerodermia. El AL se encontró en el 19,7 % del total de los estudiados: 16 % en pacientes con LES, 21,4 % en pacientes con PTI y 40 % en la AHAI. En el grupo de otras enfermedades no se halló ningún paciente con el AL positivo. El 56,3 % de los pacientes con AL positivo presentaron alguna manifestación atribuible al síndrome antifosfolípido (SAFVenous thromboembolism is a well-known complication in different autoimmune diseases. It has been established that detection of lupus anticoagulant (LA and possibly IgG type anticardiolipin antibodies (AAC in high and medium titers help to identify patients with thrombosis risk. We studied LA in 81 patients with autoimmune erythomatous lupus, 28 patients with idiopathic thrombocytopenic purpura, 15 with autoimmune hemolytic anemia and 13 patients who were included in the group covering other diseases such as small vessel skin vasculitis, combined disease of the connective tissue, rheumatoid arthritis and sclerodermia. LA was found in 19,7 % of the total number of cases, in 16% of patients with LES, 21,4 % of those with ITP and 40 % of cases with AIHA. In the group of other diseases, there was no patient with positive LA. 56,3 % of patients with positive AL showed some manifestations related to

Lupus eritematoso sistémico, en un paciente varón: a propósito de un caso

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Franco Romaní

2008-03-01

Full Text Available El lupus eritematoso sistémico es una enfermedad que afecta predominantemente a mujeres, presentándose con manifestaciones variables. Esta comunicación de caso trata sobre un paciente varón joven, que debuta con artropatía lúpica, variedad artropatía de Jaccoud. Se realiza una revisión de la literatura acerca de las características clínicas del lupus en el varón y sus diferencias con el cuadro clínico en la mujer.

El costo de la atención ambulatoria del lupus eritematoso sistémico en Colombia. Contrastes y comparaciones con otras poblaciones.

OpenAIRE

Calixto, Omar-Javier; Vargas-Zambrano, Juan-Camilo; Franco, Juan-Sebastian; Molano-Gonzalez, Nicolas; Salazar, Juan-Carlos; Rodríguez-Jímenez, Mónica; Vicente-Celis, Zayhro De San; Rojas-Villarraga, Adriana

2015-01-01

Introducción: el lupus eritematoso sistémico (LES) es considerado una enfermedad de alto costo. La expresión clínica de la enfermedad depende de la ubicación geografía y la etnicidad. El objetivo de este estudio fue el calcular los costos ambulatorios relacionado al LES en una cohorte colombiana, identificar los predictores de costos y comparar nuestro resultados con otras poblaciones. Métodos: Se realizó una aproximación de tipo prevalencia en 100 pacientes LES en quienes se evaluaron los...

Assessment of urinary TWEAK levels in Mexican patients with untreated lupus nephritis: An exploratory study

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Fabiola Reyes-Martínez

2018-03-01

Full Text Available Objectives: Urinary levels of TWEAK (uTWEAK may be correlated with the degree of lupus nephritis (LN activity. Our objective was to determine the sensitivity and specificity of uTWEAK in Mexican patients with untreated active lupus nephritis. Methods: An exploratory study was performed; four groups of patients were analyzed as follows: 1 patients with systemic lupus erythematosus (SLE without renal activity (SLE-LN, 2 patients with SLE with renal activity (SLE + LN, 3 patients with other types of glomerulopathy (glomerulonephritis, GMN, 4 and healthy patients (controls. Results: In all, 44 patients, with an average age of 35.9 ± 11.5 years, were evaluated. uTWEAK levels were higher in patients with SLE + LN compared with patients in the other groups: SLE + LN 12.88 ± 8.33, SLE-LN 3.12 ± 2.31, GMN 4.36 ± 2.31 and controls 2.41 ± 1.94 pg/mg Cr (p = 0.007. A total of 72.7% of the cases had renal activity index scores above 12, and 90.9% of the cases had scores of chronicity below 6 points. Receiver Operating Characteristic (ROC curve analysis revealed that uTWEAK levels above 4.91 pg/mg Cr had a sensitivity of 81% and a specificity of 75% for the diagnosis of renal activity due to lupus, with an area under the curve of 0.876 (95% CI: 0.75–0.99. However, no significant correlation was observed between the levels of uTWEAK and the histological findings specific to the activity and chronicity associated with SLE. Conclusions: Our study revealed that uTWEAK can adequately distinguish renal activity due to lupus, but cannot predict the degree of histological activity in Mexican patients with active lupus nephropathy. Resumen: Objetivos: Los niveles urinarios de TWEAK (uTWEAK pueden correlacionarse con el grado de actividad de nefritis lúpica (NL. Nuestro objetivo fue determinar la sensibilidad y especificidad de los uTWEAK en pacientes mexicanos con NL activa sin

Parámetros funcionales y su relación con la velocidad de marcha en adultos mayores chilenos residentes en la comunidad

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Christopher Rybertt; Silvia Cuevas; Ximena Winkler; Pamela Lavados; Sergio Martínez

2015-01-01

Introducción. La velocidad de marcha es una prueba para medir la capacidad funcional en adultos mayores. Sin embargo, los factores que influyen en esta variable han sido poco descritos en la población sudamericana. Objetivo. Determinar la relación existente entre la velocidad de marcha usual y máxima, y los parámetros de funcionalidad en chilenos adultos mayores de la comunidad. Material y métodos. Este estudio cuantitativo, observacional y descriptivo, de corte transversal, incluyó 6...

Circuitos migrantes. Itinerarios y formación de redes migratorias entre Perú, Bolivia, Chile y Argentina en el norte grande chileno

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Menara LUBE-GUIZARDI

2013-01-01

Full Text Available En el documento se analizan los resultados de la encuesta realizada con 200 migrantes peruanos y bolivianos en cuatro ciudades del Norte Grande chileno: Arica, Iquique, Antofagasta y Calama. Tras una breve introducción sobre la constitución histórica de las fronteras y la movilidad en estos territorios, se debaten las categorías clave de la investigación y se caracteriza la metodología del estudio (así como el perfil general de las personas encuestadas. Se explicita cómo los encuestados construyen sus redes migrantes y el papel de éstas como conformadoras de un capital social. Se aborda además la temporalidad de los desplazamientos y las expectativas de permanencia y movilidad geográfica de los sujetos. La discusión plantea entonces cómo la intensificación de la migración hacia el norte chileno se enmarca en circuitos migratorios referentes a la interconexión entre Perú, Chile, Bolivia y Argentina. Finalmente se explicitan algunas ideas claves que articulan las informaciones recopiladas en el estudio.

LUPUS ERITEMATOSO SISTÉMICO SÍNDROME DE CUSHING Y PSIQUIATRÍA DE ENLACE Erythematous systemic lupus, Cushing`s syndrome and psychiatric

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Ludwig Pájaro Silva

2005-01-01

Se presenta el caso de una paciente con diagnóstico de lupus eritematoso sistémico y síndrome de Cushing quien presentó síntomas afectivos de características depresivas e insomnio de conciliación, quien recibió múltiples tratamientos farmacológicos con pobre respuesta inicial. La psiquiatría de enlace consolida una alternativa de tratamiento multidisciplinario para una aproximación más eficiente a las patologías médicas con síntomas psiquiátricos.We present a case of systemic erythematosus lu...

Medios y periodistas en Twitter: el caso chileno

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Alberto López-Hermida Russo

2011-10-01

Full Text Available Las redes sociales, como Twitter, se han convertido en plataformas usadas tanto por los cibernautas como por las corporaciones a fin de alcanzar audiencias a un nivel que, hasta hace una década, parecía inimaginable. El periodismo ha sido afectado por esta tendencia, obligando a los periodistas y empresas de comunicación a emplear estas redes sociales. La incidencia de los medios y periodistas en plataformas como Twitter plantea múltiples maneras de presentarse al público. Mientras que los medios enfrentan el reto de prolongar su cierre informativo, los periodistas buscan balancear su vida su perfil profesional y personal en la red. Tras un análisis comparativo de las cuentas de periodistas y medios chilenos en Twitter, se evidencia un problema que nos permitirá estudiar y proponer pautas de acción ante el fenómeno. Así, surgen las siguientes interrogantes: ¿Los medios pueden corporativizar una herramienta social que es esencialmente de naturaleza personal? ¿Un periodista puede informar, brindar su opinión como ciudadano común, en una cuenta de Twitter creada con su perfil profesional? ¿Los perfiles de medios y periodistas pueden coexistir en la misma red social? Las respuestas a estas preguntas conllevan nuevos retos profesionales y éticos que pueden dar cabida a estudios ulteriores.

Case Report: An atypical case of systemic lupus erythematosus ...

African Journals Online (AJOL)

Background: Systemic lupus erythematosus (SLE) is a multisystem disease that can be a diagnostic conundrum. Case report: We describe a patient who presented with recurrent fleeting exudative and hemorrhagic pleural effusion. It took multiple visits over 3 months and renal biopsy to con rm the diagnosis of SLE.

Evaluación de la conducta vocacional de estudiantes con discapacidad intelectual leve en etapa de transición escuela-empleo

OpenAIRE

Labrín Díaz, Paula

2015-01-01

El objetivo de este trabajo es la construcción de instrumentos (inexistentes) que permitan evaluar los indicadores de la conducta vocacional en estudiantes con discapacidad intelectual leve que asisten al nivel laboral en centros de educación especial chilenos. Los indicadores que se consideran, acordes con los planteamientos de Rivas , son los siguientes : Historial personal, intereses vocacionales, factores de personalidad , habilidades y destrezas y estilos de aprendizaje. Los par...

Parámetros funcionales y su relación con la velocidad de marcha en adultos mayores chilenos residentes en la comunidad

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Christopher Rybertt

2015-06-01

Full Text Available Introducción. La velocidad de marcha es una prueba para medir la capacidad funcional en adultos mayores. Sin embargo, los factores que influyen en esta variable han sido poco descritos en la población sudamericana. Objetivo. Determinar la relación existente entre la velocidad de marcha usual y máxima, y los parámetros de funcionalidad en chilenos adultos mayores de la comunidad. Material y métodos. Este estudio cuantitativo, observacional y descriptivo, de corte transversal, incluyó 69 adultos mayores. La velocidad de marcha normal y la máxima se asociaron con la composición corporal (índice de masa corporal, la fuerza de las extremidades superiores (pruebas de flexiones de brazos e inferiores (pararse y sentarse en 30 segundos, la funcionalidad general (índice de Barthel, la flexibilidad de los tobillos (rango de movimiento, el equilibrio estático y dinámico (timed Up & Go test y la capacidad aeróbica (test de marcha en dos minutos. Resultados. La flexibilidad de los tobillos, la fuerza de las extremidades inferiores y la capacidad aeróbica, influyeron sobre la velocidad de marcha máxima (R2=0,65; p<0,001. La marcha normal se vio influida por la fuerza de las extremidades superiores e inferiores, y la capacidad aeróbica (R2=0,51; p<0,001. Conclusión. La velocidad de marcha, tanto normal como máxima, está influenciada principalmente por la fuerza de las extremidades inferiores y la capacidad aeróbica.

Discoid Lupus Erythematosus

Science.gov (United States)

... Name: Category: Share: Yes No, Keep Private Discoid Lupus Erythematosus Share | Discoid lupus erythematosus (DLE) is a chronic skin condition of sores ... diagnosis because other conditions can look like discoid lupus erythematosus. If the skin biopsy shows discoid lupus erythematosus, ...

Diagnóstico de la competencia comunicativa en inglés de un grupo de escolares chilenos: puntos de encuentro con su perfil estratégico

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María Gabriela Sanhueza

2013-01-01

Full Text Available Recientemente, el Ministerio de Educación de Chile aplicó por primera vez una evaluación de las habilidades receptivas en inglés a todos los estudiantes de tercer año de enseñanza media del país. Este diagnóstico permitió advertir que en las áreas de comprensión auditiva y comprensión lectora alcanzan niveles insuficientes. Sin embargo, aún es muy poco lo que se ha investigado, en el contexto educacional chileno, acerca del estado de la competencia comunicativa de nuestros jóvenes en lengua inglesa. La presente investigación se propone establecer algunos puntos de encuentro entre la descripción de la competencia comunicativa en inglés de un grupo de escolares chilenos y el perfil de estrategias de aprendizaje de lengua extranjera que les caracteriza. Este estudio corresponde a uno descriptivo, transversal, de caso único. Los datos analizados provienen de los informes de resultados de la aplicación del examen First Certificate in English y de un perfil estratégico de aprendizaje de inglés como idioma extranjero obtenido a partir del cuestionario Strategy Inventory for Language Learning.

Different Types of Lupus

Science.gov (United States)

... Twitter Facebook Pinterest Email Print Different types of lupus Lupus Foundation of America September 18, 2017 Resource ... lupus. Learn more about each type below. Systemic lupus erythematosus Systemic lupus is the most common form ...

Inmunodeficiencias en Lupus Eritematoso Sistémico

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Alonso Beato, Rubén

2016-01-01

Cada vez hay más evidencias de que las enfermedades autoinmunes sistémicas como el lupus eritematoso sistémico (LES) y las inmunodeficiencias no son enfermedades separadas. El objetivo de este estudio es determinar si la inmunodeficiencia es una constante en el LES, así como determinar la relación con el tratamiento inmunosupresor, y el tipo y gravedad de las infecciones. Otro Grado en Medicina

HISTORIA SOBRE EL PAPEL DE LAS HORMONAS Y LOS ANTICONCEPTIVOS EN EL LUPUS

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Édgar Peñaranda-Parada

2010-12-01

Full Text Available

Resumen

Tarea difícil y prolongada sería revisar la literatura para aquellos que quieran conocer el inicio de una serie de descubrimientos acerca de hormonas y lupus. Ante esto, nos hemos propuesto el objetivo de encontrar datos acerca de cómo las hormonas pueden tener una relación con la patogénesis del lupus. De esta manera hemos revisado los artículos publicados desde el inicio del siglo XX hasta su final, para poder recabar y poner en un orden esos descubrimientos y reconocer los méritos de los diferentes investigadores.

Palabras clave: Anticonceptivos hormonales, lupus eritematoso sistémico.

Historic View on the Role of Hormones and Hormonal Contraceptives in Pathogenesis of Systemic Lupus 

Abstract

Those interested in knowing a number of discoveries that link hormones and systemic lupus could face a long and troublesome search. This way, our objective in paper is to find data that shows an effect of hormones in lupus pathogenesis. Articles published on the subject since the beginning of the 20th Century until its end, were reviewed. Importance of discoveries and merits of different investigators were placed in perspective.

Key words: oral contraceptives, systemic lupus.

Exportando democracia: la implicación española en el plebiscito chileno de 1988

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Cristina García Gutiérrez

2015-06-01

Full Text Available En 1988 Chile se preparaba para un momento trascendental en su futuro político. Según el calendario marcado por la Constitución de 1980, se produciría un plebiscito que iba a decidir el modo que se iba a seguir hasta llegar a una futura transición democrática. Las opciones pasaban por un camino liderado por Augusto Pinochet a través del voto del “sí”, o la oportunidad de realizar elecciones libres a través de la opción del “no”. La coalición de oposición a la dictadura analizó otras experiencias políticas análogas de países que habían atravesado recientemente un proceso político similar. El modelo de transición política española aparecía como un ejemplo en el que fijarse desde Chile. Por su parte, España, a través del gobierno socialista liderado por Felipe González y del resto de partidos políticos del arco parlamentario, tomaron el plebiscito chileno como un proceso propio del que consideraban tenían el deber de tutelar y seguir con detenimiento. La sociedad española tampoco quedó al margen de los sucesos que rodearon al día del plebiscito. A través de diferentes fuentes documentales el presente artículo muestra la naturaleza de esta relación que aunó a los dos contextos políticos explicando los porqués del interés español en el proceso plebiscitario chileno.

Algunas consideraciones respecto del fallo del tribunal constitucional chileno relativo a la distribución de la “píldora del día después”

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Juan Pablo Beca Frei

2009-01-01

En este artículo damos los fundamentos jurídicos de por qué resulta plenamente legítimo que el Tribunal Constitucional chileno se pronuncie sobre algunos aspectos de las Normas Chilenas sobre Fertilidad, en lo que concierne a la entrega de anticonceptivos de emergencia. En este fallo, el Tribunal Constitucional determinó que las normas contenidas en el Decreto Supremo Nº 48, de 26 de enero de 2007, del Ministerio de Salud son –desde el punto de vista jurídico– incompatibles con nuestras norma...

Violencia política en el sur de Chile : la Alianza Territorial Mapuche Pü Löf Xawün y el Estado chileno en el gobierno de Michelle Bachelet.

OpenAIRE

Donoso Jiménez, Javiera

2011-01-01

Con el advenimiento Michelle Bachelet al Palacio de La Moneda, segundo gobierno socialista postdictadura, se creyó que la democracia chilena había llegado a su consolidación democrática. Sin embargo, esta nueva democracia no contempló ni implicó necesariamente la disminución de la violencia política estatal sobre la sociedad civil tanto en el ámbito estructural, como simbólico y represivo. Lo anterior se comprueba al observar la evolución del conflicto entre el Estado chileno y el pueblo M...

El exilio comunista chileno: 1973-1989 = O exílio comunista chileno: 1973-1989 = Chilean Communist Exile: 1973-1989

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Ulianova, Olga

2013-01-01

Full Text Available Analisamos o exílio comunista durante a ditadura militar chilena como um caso particular de exílio político contemporâneo, de caráter multiclassista e de alta organicidade. Baseado em documentos do arquivo interno do Partido Comunista Chileno no exterior, assim como dos arquivos da antiga RDA, da URSS e entrevistas, discutimos a importância da interação com os socialismos reais tardios na evolução da cultura política do PCCH e as mudanças na sua linha política

Discoid Lupus Erythematosus

Science.gov (United States)

... Name: Category: Share: Yes No, Keep Private Discoid Lupus Erythematosus Share | Discoid lupus erythematosus (DLE) is a chronic skin condition of ... occur. A small percentage of patients with discoid lupus can develop disease of the internal organs, which ...

Adaptaciones metodológicas para el análisis del discurso de niños con discapacidad intelectual: narrando sin lenguaje

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Manghi Haquin, Dominique; Otárola Cornejo, Fabiola; Arancibia M., Marianela

2016-01-01

Resumen Dada la necesidad de comprender las formas de comunicación de personas con discapacidad intelectual para favorecer su participación social, este estudio trata la narración como una instancia discursiva autogestionada más allá del lenguaje. El objetivo es sistematizar una metodología que permita explorar su discurso narrativo usando una perspectiva multimodal. La descripción corresponde a las narraciones de quince escolares chilenos con discapacidad intelectual y escaso desarrollo de l...

EL PENTECOSTALISMO CHILENO COMO RESPUESTA A LOS CAMBIOS SECULARIZADORES DEL SIGLO XIX. UNA MIRADA EN RETROSPECTIVA

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Angélica Barrios Bustamante

2017-06-01

Full Text Available Este artículo se propone volver la mirada hacia el origen del movimiento pentecostal chileno para sostener que este responde en su planteamiento sobre la modernidad a un evento de recomposición religiosa que no se encaminó hacia la privatización de la religión, sino a la conquista de los espacios públicos en un esfuerzo de resacralizarlos. El método de trabajo fue un análisis historiográfico, principalmente de fuentes hemerográficas y revisión de literatura sobre el pentecostalismo, que incorpora como lente de observación el enfoque de la secularización a fin de entender como los y las pentecostales interpretaron desde su experiencia religiosa el proceso de modernidad, en relación directa con el protestantismo misionero y el contacto con un catolicismo reformado tocado por los cambios finiseculares. Nuestro estudio nos permite sustentar que el pentecostalismo fue un fenómeno religioso que surge y se consolida en el proceso de modernidad latinoamericana, en ese contacto ha formulado su propuesta religiosa en medio de una trama compleja y cambiante respecto al papel que las instituciones y la sociedad han jugado desde el siglo XIX.

El movimiento estudiantil chileno del 2011 en intervenciones discursivas del Presidente Piñera

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Claudio Araya Seguel

2014-06-01

Full Text Available Este artículo muestra evidencia lingüístico-discursiva del intento del Presidente Piñera por acallar las influencias sociales del movimiento estudiantil chileno del año 2011. Desde una mirada crítica se da cuenta del comportamiento discursivo de este hablante en el marco del primer conflicto social que enfrentó el nuevo gobierno de derecha en Chile. El valor teórico-metodológico de este estudio radica en la mirada triangular a las intervenciones discursivas. A través del análisis de un corpus de cuatro intervenciones presidenciales desde las perspectivas de las funciones estratégicas del discurso político, la teoría de la valoración y la lingüística de corpus se observa cómo Piñera deslegitima al movimiento social asociando las demandas referidas a educación con la violencia y el desorden público generado en el contexto de las crecientes marchas a lo largo del país.

El impacto social y cultural de la publicidad entre los jóvenes chilenos The Social and Cultural Impact of Advertising among Chilean Youths

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Maite Rodríguez Salineros

2010-10-01

Full Text Available El presente trabajo analiza el impacto de la publicidad entre jóvenes chilenos de distintos estratos socioeconómicos, con el objetivo de identificar la relación que establecen con la publicidad y la particular incorporación que hacen de ésta en sus estrategias de socialización. Por lo tanto, no se pretende dar cuenta de lo que la publicidad hace con los jóvenes, sino de lo que los jóvenes hacen con la publicidad a través de sus prácticas de recepción y apropiación. Para esto, se realizó un estudio sobre la base de grupos de discusión a jóvenes de ambos sexos, de edades entre 15 y 24 años provenientes de los niveles socioeconómicos altos y bajos residentes en Santiago de Chile. Los resultados que arrojó el estudio dan cuenta de que la publicidad es asumida como parte constitutiva de la oferta medial, la que es utilizada como información comercial y referente cultural de nuevos valores estéticos. Junto con esto, la publicidad adquiere el carácter de agente de socialización, al incorporar los contenidos de los mensajes publicitarios en las conversaciones con sus pares. Finalmente, este trabajo concluye que la publicidad entre los jóvenes chilenos estudiados, se presenta como una realidad sociocultural de primer orden, en cuanto actor central de su vida cotidiana.This work analyzes the impact of advertising among Chilean youngsters of different socioeconomic background. We aim to identify the relationship that this group establishes with advertising and, in particular, the way they incorporate it in their socialization strategies. We do not address what advertising does to youngsters, but instead what youngsters do with advertising in their practices of appropriation and reception of it. The research design included focus groups of male and female youngsters living in Santiago de Chile between 15 and 24 years of age coming from both high and low-income background. The conclusion of our research is that advertising is assumed

Children & Teens (with Lupus)

Science.gov (United States)

... nine. blog Lupus at school: A guide for parents and kids Advice for communicating with your child's school about their lupus and ... teens on adjusting to life with lupus For teens, living with lupus can require some major ... in school Advice from parents and education experts on 504 and Individualized Education ...

Tolerance induced by anti-DNA Ig peptide in (NZB×NZW)F1 lupus mice impinges on the resistance of effector T cells to suppression by regulatory T cells.

Science.gov (United States)

Yu, Yiyun; Liu, Yaoyang; Shi, Fu-Dong; Zou, Hejian; Hahn, Bevra H; La Cava, Antonio

2012-03-01

We have previously shown that immune tolerance induced by the anti-DNA Ig peptide pCons in (NZB×NZW)F(1) (NZB/W) lupus mice prolonged survival of treated animals and delayed the appearance of autoantibodies and glomerulonephritis. Part of the protection conferred by pCons could be ascribed to the induction of regulatory T cells (T(Reg)) that suppressed the production of anti-DNA antibodies in a p38 MAPK-dependent fashion. Here we show that another effect of pCons in the induction of immune tolerance in NZB/W lupus mice is the facilitation of effector T cell suppression by T(Reg). These new findings indicate that pCons exerts protective effects in NZB/W lupus mice by differentially modulating the activity of different T cell subsets, implying new considerations in the design of T(Reg)-based approaches to modulate T cell autoreactivity in SLE. Copyright © 2011 Elsevier Inc. All rights reserved.

Disidencias sexuales en el sistema escolar chileno: represión e invisibilización

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Juan Cornejo Espejo

Full Text Available Resumen El objetivo del artículo es dar a conocer los resultados de una investigación llevada a cabo en base al registro de denuncias de discriminación por orientación sexual en el sistema escolar chileno entre los años 2009 y 2015. El catastro de esa información, proveniente de todas las regiones del país, fue elaborado por el Ministerio de Educación de Chile (MINEDUC. De ese catastro se extrajeron las denuncias específicas relativas a discriminación homofóbica. La muestra estuvo conformada por 95 casos, de los cuales el 61,5% correspondió a mujeres y el 38,4% a hombres. La metodología empleada privilegió el análisis cualitativo, siguiendo los supuestos de la Teoría Fundamentada. El análisis textual se hizo teniendo como referencia las anotaciones del funcionario del MINEDUC que acogió la denuncia, las cuales fueron conservadas en su forma original, respetando las expresiones y énfasis dados al discurso. Los resultados se presentan a través de dos codificaciones axiales, una de ellas referida a las causas que motivaron la discriminación en los establecimientos denunciados y la segunda a los efectos psico-emocionales, sociales y pedagógicos que ocasionó esa discriminación en las víctimas. En la codificación selectiva, se caracterizaron los elementos constitutivos de la discriminación homofóbica presente en el sistema escolar chileno en el período en estudio. Los principales hallazgos de la investigación muestran que las causales que suscitaron las denuncias estuvieron motivadas por medidas disciplinarias adoptadas por los establecimientos educacionales, consideradas arbitrarias por los denunciantes. Medidas que buscaban reprimir y sancionar a los estudiantes LGBT disidentes sexuales, con el consecuente reforzamiento de la homofobia escolar.

EL OCASO DE LA CLAUSURA: MUJERES, RELIGIÓN Y ESTADO NACIONAL. EL CASO CHILENO

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Sol Serrano

2009-12-01

Full Text Available La decadencia del modelo religioso femenino representado por los conventos de monjas contemplativas, entre fines del XVIII y la primera mitad del siglo XIX, es parte de un proceso de reforma propia del despotismo ilustrado, del liberalismo de los estados nacionales y también, en el caso chileno que aquí se estudia, del reformismo eclesiástico. Este artículo sugiere que las monjas contemplativas dejaron de ser mujeres para el liberalismo, por no cumplir su rol de madres, y en el catolicismo fueron desplazadas por las religiosas de vida activa, que eran un modelo de religiosas en el mundo que cumplían roles de madres sociales. La exclusión de las mujeres de los derechos políticos está vinculada con este proceso, en cuanto la formación del nuevo espacio público requería la formación de un espacio privado gobernado por madres. Este artículo estudia las tres etapas del reformismo ilustrado, del liberal y del religioso en el caso chileno.The decline of the women religious model represented by contemplative nun convents between the end of the eighteenth century and the first half of the nineteenth, was part of a reform process experienced in different spheres of influence. Among them it is possible to mention the enlightened despotism, the liberalism exerted by National States and the ecclesiastical reformism of Chile. This article shows that contemplative nuns stopped being considered as women for liberalism because they did not fulfill a mother role. Moreover they were displaced within the Catholic realm by religious women with active roles in society, who fulfilled the role of social mothers. The exclusion of women from the enjoyment of political rights was linked to this process because the formationof a new public space required the conformation of a private space governed by mothers.

77 FR 38305 - Guidance for Industry on Lupus Nephritis Caused by Systemic Lupus Erythematosus-Developing...

Science.gov (United States)

2012-06-27

...] Guidance for Industry on Lupus Nephritis Caused by Systemic Lupus Erythematosus--Developing Medical... ``Lupus Nephritis Caused By Systemic Lupus Erythematosus--Developing Medical Products for Treatment... of medical products for the treatment of lupus nephritis. Dated: June 22, 2012. Leslie Kux, Assistant...

Connectedness Among Chilean Adolescents: Factor Analysis of the Hemingway Measure of Adolescent Connectedness La Conectividad Entre Adolescentes Chilenos: Un Análisis Factorial de la Hemingway Measure of Adolescent Connectedness

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Benedict T McWhirter

2011-05-01

Full Text Available The construct of connectedness was investigated among 390 Chilean adolescents using the Hemingway Measure of Adolescent Connectedness (Hemingway; Karcher, 2003. Participants were 7th-12th graders at an urban Santiago Catholic school. Results of a principal-axis exploratory factor analysis revealed an 11 factor structure that accounts for 61.92% of total explained variance of adolescent connectedness measured by the Hemingway, similar to results found in the adolescent samples in the United States. Two additional Hemingway subscales (connectedness to siblings and to boyfriend/girlfriend are also described. Correlations between domains of connectedness and additional data obtained from these adolescents, their parents, and their teachers support the construct validity of the measure in this Chilean sample. Connectedness is an important protective factor among adolescents across many national contexts and the Hemingway is a promising measure for use with Chilean adolescents.Se examinó el constructo conectividad en 390 adolescentes chilenos en un colegio urbano y católico de Santiago. Mediante un análisis factorial exploratorio de la escala Hemingway Measure of Adolescent Connectedness (Hemingway, Karcher, 2003 se observó una estructura de 11 factores que da cuenta de un 61,92% de la varianza explicada de la conectividad de los adolescentes medida por la escala Hemingway, lo cual es muy similar a los resultados obtenidos en muestras de adolescentes estadounidenses. También se describen dos subescalas adicionales (la conectividad con los/las hermanos/as y con los/las pololos/as. Las relaciones entre los factores de conectividad y los datos reportados por los adolescentes, sus padres y profesores contribuyen también a la validez de constructo de la escala en esta muestra chilena. Para los adolescentes de distintos contextos culturales la conectividad es un factor importante de protección y la escala Hemingway es un instrumento de uso prometedor

Lupus anticoagulants and antiphospholipid antibodies

Science.gov (United States)

Blood clots - lupus anticoagulants; DVT - anticoagulants ... Most often, lupus anticoagulants and aPL are found in people with diseases such as systemic lupus erythematosus (SLE). Lupus anticoagulants and ...

Tratamiento estomatológico interdisciplinario del lupus eritematoso generalizado. Presentación de un caso

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Paola Gómez-Contreras

2015-08-01

Full Text Available El lupus eritematoso generalizado es una enfermedad crónica autoinmunitaria del tejido conectivo. Su compromiso multisistémico convierte a los pacientes que lo padecen en individuos de alto riesgo para el tratamiento estomatológico, por lo que se deben tener consideraciones individualizadas para su atención. Estomatológicamente en 2 a 80% de los pacientes se observan úlceras orales, enfermedad periodontal, candidiasis oral, mucositis por inmunodepresores, síndrome de Sjögren y predisposición a infecciones. Reportamos el tratamiento estomatológico de una niña con lupus eritematoso generalizado y caries dental con el objetivo de dar a conocer las consideraciones interdisciplinarias, específicas e individualizadas antes, durante y después del tratamiento.

Lupus eritematoso sistémico síndrome de cushing y psiquiatría

OpenAIRE

Ludwig Pájaro Silva

2005-01-01

Se presenta el caso de una paciente con diagnóstico de lupus eritematoso sistémico y síndrome de Cushing quien presentó síntomas afectivos de características depresivas e insomnio de conciliación, quien recibió múltiples tratamientos farmacológicos con pobre respuesta inicial. La psiquiatría de enlace consolida una alternativa de tratamiento multidisciplinario para una aproximación más eficiente a las patologías médicas con síntomas psiquiátricos.

Lupus Nephritis

Science.gov (United States)

... in men and most often strikes during the child-bearing years. Nine out of 10 people who have lupus are women. Lupus is also more common in people of African or Asian background. African Americans and Asian Americans ...

Divulgación de información sobre responsabilidad social por los bancos chilenos: una aproximación desde la teoría de la legitimidad

OpenAIRE

Gómez, Nagore Aranguren; Cerna, Luis Martinez

2010-01-01

Este estudio indaga en la revelación de información en el ámbito de la responsabilidad social corporativa en el sector bancario chileno. La teoría de la legitimidad y la metodología del análisis de contenido aplicado a los informes anuales y a las páginas web de seis bancos privados chilenos ayudan a nuestro propósito. Los resultados muestran que los bancos chilenos revelan información sobre responsabilidad social corporativa, constatándose diferencias en el grado y el tipo de información dep...

El Movimiento estudiantil chileno y el proceso de reforma universitaria, 1967-1968

DEFF Research Database (Denmark)

Cancino, Hugo

2012-01-01

En la presente ponencia analizamos el contexto histórico y cultural del movimiento de reforma de la Universidad de Chile, 1967-68 y su gestación en la Facultad de Filosofía y Educación. Este movimiento que se inscribió en la dilatada tradición de lucha de los estudiantes chilenos y latinoamericanos...

Life experiences with Systemic Lupus Erythematosus as reported in outpatients' perspective: a clinical-qualitative study in Brazil Vivencias con Lupus Eritematoso Sistémico como relatadas en la perspectiva de pacientes ambulatoriales: un estudio clínico-cualitativo en Brasil Experiências de vida com Lupus Eritematoso Sistêmico como relatadas na perspectiva de pacientes ambulatoriais no Brasil: um estudo clínico-qualitativo

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Gilberto Dari Mattje

2006-08-01

Full Text Available This study aimed to know lupus outpatients' life experiences, in terms of the meanings they attributed to several phenomena associated to the process of becoming ill. Systemic Lupus Erythematosus is a chronic inflammatory disease, probably caused by a combination of inborn/hereditary predispositions and environmental factors, which leads to an abnormal stimulation of the immune system. Lupus life experience is associated to important psychosocial adaptation mechanisms of affected people. This work had a clinical-qualitative design and was performed in the dermatology service of a Brazilian General Hospital. The method included purposive sample, and a semistructured interview with open-ended questions was applied. After categorizing the interviewees' discourse, the discussion employed psychodynamic theories. The patients' reactions included the attempt to rebuild their relationships with their own strengths. Lupus patients' familiar and interpersonal conflicts seem to be associated with the idea that family and friends do not understand the nature of the disease.Este estudio objetivó conocer vivencias de pacientes ambulatoriales com lupus, en términos de los significados que atribuyeron a varios fenómenos asociados al proceso de adolecer. Lupus Eritematoso Sistémico es una enfermedad inflamatoria crónica y su causa es probablemente una combinación de predisposiciones congénitas/hereditarias y de factores ambientales, que conducen a un estímulo anormal del sistema inmune. La vivencia del Lupus se asocia a importantes mecanismos psicosociales de adaptación. Este trabajo ha tenido diseño clínico-cualitativo, realizado en un servicio de dermatología de un hospital general brasileño. El método incluyó muestra proposital y una entrevista semidirigida con preguntas abiertas fue aplicada. Después de categorizar los discursos de los entrevistados, la discusión empleó teorías psicodinámicas. Las reacciones de los pacientes abarcaron la

Kidney disease in lupus is not always 'lupus nephritis'

NARCIS (Netherlands)

H.J. Anders (Hans-Joachim); J.J. Weening (Jan)

2013-01-01

textabstractIn lupus erythematosus, elevated serum creatinine levels and urinary abnormalities implicate a kidney disorder, which may not always be lupus nephritis as defined by the current classification of the International Society of Nephrology/Renal Pathology Society. The signs of renal

Monumentos privados : arte chileno de Avanzada (1977-1982

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María Íñigo Clavo

2004-01-01

Full Text Available El siguiente texto realiza un recorrido por la historia del arte conceptual chileno durante la dictadura. Desde mediados-finales de los setenta una serie de artistas comenzaron a trabajar desarrollando nuevos lenguajes, técnicas y estrategias de representación; todos ellos participaron de una crítica a la política militar unas veces de forma individual y desde lo personal y otras desde lo colectivo. El texto se divide en dos partes fundamentales, la primera de ellas se detiene en obras individuales que la mayoría de las veces trabajaban fuera de las galerías de arte, interactuando con el entorno, fuera de la oficialidad artística que marcaban las instituciones. La segunda parte recupera los trabajos artísticos del CADA, un grupo de artistas que realizaron varias acciones políticas en el espacio público.This text makes a route through the art history of conceptual Chilean art during the dictatorship. Since about the middleend ofthe 70’s decade sume artists started to work developing new languages, techniques and strategies of representation; all of them shared of a critical discoflrse to the military politic, sometime looking for personal ways and other times from collective actions. The text is divided in two fundamental parts. The first one regards in individual works that most of the time work ofltside of the art galleries, acting with the environment, ofltside of the officials institutions. The second part revises the art works of CADA, a group of artist that carried out several political actions in the public space.

Burden of lupus on work: Issues in the employment of individuals with lupus.

Science.gov (United States)

Agarwal, Neelam; Kumar, Vinod

2016-10-17

Systemic lupus erythematosus (SLE) or Lupus is one of the leading causes of work disability in the United States, accounting for about 20% of the more than estimated 1.5 million Americans with a work disability. The symptoms of lupus can have a profound impact on the person's employment. Impacts of lupus are more pronounced among young and middle-adulthood. Studies have shown that loss in work hours cost the nation nearly $13 billion annually. The loss also impacts the individual's work, quality of life, self-management, and self-efficacy. In this article, the author describes the financial burden of lupus. The article also describes the substantial impact of lupus on employment outcomes for individuals living with the condition. The author also reviews major signs and symptoms of disease and their impact on employment. Findings from this research can be used to identify various accommodations and strategies for individuals to prevent flare-ups. The paper presents innovative strategies that include early interventions and how employers andco-workers can provide helpful support that includes job accommodations to individuals with lupus.

Lupus Foundation of America

Science.gov (United States)

... Store Read About Our $3.8M Commitment to Stem Cell Research. Learn More Committed to Advancing Research on Lupus ... person with lupus? Get Answers Latest News & Stories Research News | Nov. 16, 2017 Major Lupus Stem Cell Study Receives Funding $3.8 million committed by ...

Representaciones sociales en torno al "conflicto" estado chileno - pueblo mapuche en jóvenes universitarios chilenos: un estudio con Redes semánticas naturales

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Marianela Denegri Coria

2015-09-01

Full Text Available Esta investigación tuvo como propósito realizar una primera aproximación a las representaciones sociales sobre el "conflicto estado-nación y pueblo mapuche", en estudiantes universitarios del área de Ciencias Sociales de una universidad estatal del sur de Chile. Se trabajó con la técnica de redes semánticas naturales, utilizando cuatro frases-estímulo. Los resultados indican que existe una percepción de la circunstancia en la que se resalta la situación de conflicto, con una mirada muy negativa con respecto al gobierno, el sistema judicial, y los medios de comunicación. Se discuten las implicancias para el futuro desempeño profesional de estos estudiantes en caso de desenvolverse en un contexto laboral de intervención directa o indirecta en este conflicto.

Contraception in women with systemic erythematosus lupus = Anticoncepción en mujeres con lupus eritematoso sistémico

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Luis Alonso González Naranjo

2013-07-01

Full Text Available The use of contraceptives, particularly of those containing estrogens by women with systemic lupus erythematosus (SLE, has been thought to carry risks such as disease exacerbation, thrombosis and other adverse effects. However, the available evidence suggests that many women with SLE, particularly those with stable disease, are not at increased risk of disease flare while taking oral contraceptives and therefore can be good candidates for most contraceptive methods, including the hormonal ones. Contrariwise, women with positive antiphospholipid antibodies are at increased risk of arterial and venous thrombosis and therefore the use of combined hormonal contraceptive methods should be avoided in them.

A 12-year retrospective review of bullous systemic lupus erythematosus in cutaneous and systemic lupus erythematosus patients.

Science.gov (United States)

Chanprapaph, K; Sawatwarakul, S; Vachiramon, V

2017-10-01

Objective The aim of this study was to investigate the clinical features, laboratory findings, systemic manifestations, treatment and outcome of patients with bullous systemic lupus erythematosus in a tertiary care center in Thailand. Methods We performed a retrospective review from 2002 to 2014 of all patients who fulfilled the diagnostic criteria for bullous systemic lupus erythematosus to evaluate for the clinical characteristics, extracutaneous involvement, histopathologic features, immunofluorescence pattern, serological abnormalities, internal organ involvement, treatments and outcome. Results Among 5149 patients with cutaneous lupus erythematosus and/or systemic lupus erythematosus, 15 developed vesiculobullous lesions. Ten patients had validation of the diagnosis of bullous systemic lupus erythematosus, accounting for 0.19%. Bullous systemic lupus erythematosus occurred after the diagnosis of systemic lupus erythematosus in six patients with a median onset of 2.5 months (0-89). Four out of 10 patients developed bullous systemic lupus erythematosus simultaneously with systemic lupus erythematosus. Hematologic abnormalities and renal involvement were found in 100% and 90%, respectively. Polyarthritis (40%) and serositis (40%) were less frequently seen. Systemic corticosteroids, immunosuppressants, antimalarials and dapsone offered resolution of cutaneous lesions. Conclusion Bullous systemic lupus erythematosus is an uncommon presentation of systemic lupus erythematosus. Blistering can occur following or simultaneously with established systemic lupus erythematosus. We propose that clinicians should carefully search for systemic involvement, especially hematologic and renal impairment, in patients presenting with bullous systemic lupus erythematosus.

UNIPERSONALIDAD Y SOCIEDAD CON UN SOLO SOCIO; ALCANCES DE SU RECONOCIMIENTO EN LA ESTRUCTURA DOGMÁTICA DEL DERECHO CHILENO Unipersonality And Company With Only One Partner; Some Scope Of His Insertion In De Dogmatic Structure Of Chilean Law

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Eduardo Jequier Lehuedé

2011-01-01

Full Text Available La presente investigación surge a partir del definitivo reconocimiento en Chile delfenómeno de la unipersonalidad y, recientemente, de la Sociedad por Acciones -SpA- con un solo socio en su vertiente originaria. Apunta en concreto a explorar el real impacto de la figura unipersonal en la estructura dogmática del derecho chileno y del derecho de sociedades en particular, construida a partir del concepto de sociedad contemplado en el artículo 2053 del Código Civil. Se analiza el origen de la unipersonalidad en el derecho comparado y sus concretas manifestaciones en el derecho chileno vigente, incluida la Empresa Individual de Responsabilidad Limitada -EIRL-, explicando en definitiva la incardinación y los efectos que genera la nueva figura de la sociedad de un solo socio en un sistema positivo inspirado, originariamente al menos, en la noción contractualista de la sociedad en general y en la concepción corporativa tradicional de la sociedad de capital en particular.The present investigation arises from the definitive recognition in Chile of the one man company phenomenon and, recently, of the Stock Company -SpA- with only one partner, in its original aspect. Its objective specifically points out to explore the real impact of this figure in the dogmatic structure of the Chilean law and specially of the company law, built from the concept of a company considered in the article 2053 of the Civil Code. What is being analyzed here is the one man company figure in compared law and its concrete declarations in the current Chilean law, including the Individual Limited Liability Corporation, explaining ultimately the incardination and the possible effects that can arise the one man company figure in a positive system, inspired originally at least, in the contractual sense of the company in general and the traditional corporative conception of the capital company particularly.

El significado de la histerectomía para un grupo de hombres chilenos parejas de histerectomizadas

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Alejandra Araya Gutiérrez

2012-12-01

Full Text Available Se objetivó conocer el significado de la histerectomía para un grupo de hombres chilenos, parejas de mujeres histerectomizadas (HPMH. Estudio cualitativo, con entrevistas en profundidad realizadas a 15 hombres, parejas de mujeres histerectomizadas, entre Mayo y Septiembre del 2010, previa aprobación de dos Comités de Ética. Para el análisis de los datos se utilizó la perspectiva fenomenológica descrita por Giorgi, y se realizó el análisis de contenido según Krippendorff. Los criterios de Creswell fueron utilizados para evaluar la credibilidad del análisis y asegurar la validez descriptiva. Emergieron cinco dimensiones que representan aspectos únicos del significado de la histerectomía para los hombres parejas de mujeres histerectomizadas: síntomas, comentarios, atributos del útero, preocupaciones, y cambios en la sexualidad. Educar los hombres parejas de mujeres histerectomizadas es una acción fundamental para apoyar a las mujeres que serán sometidas a una histerectomía, siendo necesaria su incorporación en el plan de cuidados de ellas.

El significado de la histerectomía para un grupo de hombres chilenos parejas de histerectomizadas

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Alejandra Araya Gutiérrez

Full Text Available Se objetivó conocer el significado de la histerectomía para un grupo de hombres chilenos, parejas de mujeres histerectomizadas (HPMH. Estudio cualitativo, con entrevistas en profundidad realizadas a 15 hombres, parejas de mujeres histerectomizadas, entre Mayo y Septiembre del 2010, previa aprobación de dos Comités de Ética. Para el análisis de los datos se utilizó la perspectiva fenomenológica descrita por Giorgi, y se realizó el análisis de contenido según Krippendorff. Los criterios de Creswell fueron utilizados para evaluar la credibilidad del análisis y asegurar la validez descriptiva. Emergieron cinco dimensiones que representan aspectos únicos del significado de la histerectomía para los hombres parejas de mujeres histerectomizadas: síntomas, comentarios, atributos del útero, preocupaciones, y cambios en la sexualidad. Educar los hombres parejas de mujeres histerectomizadas es una acción fundamental para apoyar a las mujeres que serán sometidas a una histerectomía, siendo necesaria su incorporación en el plan de cuidados de ellas.

Presiones empresariales a los medios: El caso de un medio deportivo chileno

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Claudia P. Lagos Lira

2015-09-01

Full Text Available El propósito de este artículo es analizar cómo los intereses corporativos modelan el sistema de medios en Chile y el ejercicio periodístico. Las implicancias para la democracia también son consideradas en consideración. Este artículo usa un caso de estudio para mostrar cómo los intereses empresariales operan concretamente en los medios para fortalecer los intereses privados en vez de los públicos. El artículo sugiere que el periodismo chileno está constreñido principalmente por un marco neoliberal, jugando un rol colaborativo para no entorpecer el medioambiente empresarial debido a que éste genera empleos y crecimiento económico para el país. En segundo lugar, el texto explora el caso, analizando en el marco de la perspectiva del periodismo del desarrollo, siguiendo un discurso público más amplio sobre los requerimientos de desarrollo para Chile. De hecho, las corporaciones periodísticas y la esfera económica chilenas están fuertemente relacionadas a pesar de las tensiones de los años recientes en el sistema de medios chileno.

¿EDUCADORES O CONSUMIDORES? DISCREPANCIA DEL YO, CONSUMO Y VALORES MATERIALES EN ESTUDIANTES CHILENOS DE PEDAGOGÍA

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Marianela Denegri Coria

2014-01-01

Full Text Available El presente artículo tiene como propósito caracterizar las relaciones existentes entre la discrepancia del Yo, las actitudes hacia la compra y valores materialistas en estudiantes de Pedagogía considerando diferencias de género. Se aplicaron las escalas de Discrepancia del Yo, Actitudes hacia la Compra y Valores Materiales, en una muestra de 167 estudiantes chilenos de las carreras de Pedagogía en Historia de dos universidades del Sur de Chile. Los resultados obtenidos, evidencian correlaciones significativas entre las dimensiones de discrepancia del Yo físico, intelectual y económico, y las actitudes impulsivas y compulsivas hacia la compra; así como en las dimensiones de valores materiales vinculadas al éxito social y felicidad personal. En cuanto al género, se observa en las mujeres un perfil de ambivalencia actitudinal, donde coexiste la racionalidad con la compulsividad. A partir de la relevancia social del futuro ejercicio profesional de los estudiantes de pedagogía, los resultados se discuten considerando la importancia de la inclusión de la educación económica y financiera en la formación inicial de profesores, con un fuerte énfasis en la toma de conciencia acerca de sus actitudes y valores hacia el consumo.

Lupus nephritis

African Journals Online (AJOL)

1991-03-02

Mar 2, 1991 ... A recent large Australian series! on lupus nephritis emphasises .... patent capillary lumina and thickened capillary walls. ... (Australia). 135. 27. 58. 15. This study (RSA). 51. 33. 63. 4 have been documented.2-5 All included patients with lupus nephritis, but while the series from Natal' gave a detailed list.

The LupusQoL and associations with demographics and clinical measurements in patients with systemic lupus erythematosus.

Science.gov (United States)

McElhone, Kathleen; Castelino, Madhura; Abbott, Janice; Bruce, Ian N; Ahmad, Yasmeen; Shelmerdine, Joanna; Peers, Kate; Isenberg, David; Ferenkeh-Koroma, Ada; Griffiths, Bridget; Akil, Mohammed; Maddison, Peter; Gordon, Caroline; Teh, Lee-Suan

2010-11-01

Having developed and validated a disease-specific health-related quality of life (HRQOL) measure for patients with systemic lupus erythematosus (SLE), the LupusQoL, we determined its relationship to demographic and clinical measurements in a group of patients with SLE. A group of 322 outpatients completed the LupusQoL. Demographic (age, sex, marital status, ethnicity) and clinical variables (disease duration, disease activity, damage) were recorded. Associations between the 8 LupusQoL domains and age, disease duration, disease activity, and damage were explored using Spearman's correlation coefficients. Differences in LupusQoL scores were examined for sex and marital status using the Mann-Whitney U test. Ethnic groups were compared using ANOVA. All domains of LupusQoL were impaired, with fatigue (56.3) being the worst affected and body image (80.0) the least. The correlations between the LupusQoL domain scores and age (r = -0.01 to -0.22) and disease duration (r = 0 to 0.16) were absent or weak. Similarly, there were no significant differences in the LupusQoL scores regarding sex, marital status, or the 3 main ethnic groups (Black-Caribbean, Asian, White). Although there were statistically significant correlations between the scores of the LupusQoL domains and some scores of the British Isles Lupus Assessment Group index (r = -0.22 to 0.09) and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (r = -0.29 to 0.21), these were weak. HRQOL was impaired in this cohort of outpatients with SLE as assessed by the validated lupus-specific LupusQoL. There were no clinically important associations between the 8 domains of the LupusQoL and clinical or demographic variables in this group of patients. Thus, the LupusQoL is a relatively independent outcome measure in patients with SLE.

"Bound" globulin in the skin of patients with chronic discoid lupus erythematosus and systemic lupus erythematosus

NARCIS (Netherlands)

Cormane, R.H.

1964-01-01

In what respect chronic discoid lupus erythematosus is related to systemic lupus erythematosus is still uncertain. In discoid lupus the lupus-erythematosus (L.E.) phenomenon is negative, and the history does not suggest vascular lesions or involvement of serous membranes. In both diseases the

LA ESTRATEGIA DE CITICORP EN CHILE. Capitulo 3. EL MERCADO FINANCIERO CHILENO

OpenAIRE

Fernando Rubio

2004-01-01

Esta es la tercera parte de una serie que forman una investigación más amplia titulada “La Estrategia de Citicorp en Chile: Un Intento de Investigación”. Aquí se describe la naturaleza, reglamentación, estado actual y perspectivas de más de los 25 segmentos del mercado financiero chileno, desde la banca hasta las administradoras de fondos de pensiones.

Living with Lupus

Science.gov (United States)

... How Lupus Affects the Body Lupus and the Workplace Mental Health and Wellbeing Overlapping Diseases Reproductive Health Self-Advocacy Treatment Options all resource types Videos Articles Downloadable PDFs Slideshow Q & A List Personal Stories ...

Características clínicas y comorbilidades de pacientes con lupus eritematoso sistémico en niños y adultos

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Carlos Daniel Coronado Alvarado

2018-01-01

Full Text Available INTRODUCCIÓN: el lupus eritematoso sistémico es una enfermedad autoinmune crónica; se presenta mayormente en mujeres en etapa reproductiva y es menos frecuente en niños.   OBJETIVO: comparar las manifestaciones clínicas, comorbilidades y farmacoterapia en niños y adultos con lupus eritematoso sistémico (LES.   MATERIAL Y MÉTODOS: se seleccionaron 127 expedientes clínicos de pacientes con diagnóstico de LES; 36 menores de edad de un hospital pediátrico (grupo A y 91 adultos de un hospital general (grupo B. Recolectamos información respecto a las manifestaciones clínicas al diagnóstico en los niños y adultos, así como las comorbilidades relacionadas y mortalidad, atendiendo los criterios de la American College of Rheumatology, también del tipo de medicamentos empleados. Estadísticas utilizadas: cálculo de frecuencias, porcentajes, la prueba de ji cuadrada, prueba exacta de Fisher, razón de momios e intervalos de confianza.   RESULTADOS: en niños predominaron: eritema malar (p = < 0.01, vasculitis (p < 0.01, fotosensibilidad (p < 0.01, síndrome nefrítico (p < 0.01, alteraciones leucocitarias (p < 0.01, derrame pleural, anemia, derrame pericárdico, sepsis y hepatopatía; además, el número de medicamentos empleados fue mayor. En adultos predominaron: artralgia (p < 0.01, pancitopenia (p = 0.025, alopecia (p < 0.01, sinovitis (p = 0.044 y falla renal crónica (p = 0.04. Los fármacos usados en el grupo A fueron: hidroxicloroquina (p < 0.01, glucocorticoides (p = 0.14 y micofenolato (p = 0.28, la mortalidad en niños fue de 25% y en 91 adultos ocurrió en 5 (0.05%.   CONCLUSIONES: las manifestaciones clínicas en niños muestran mayor lesión cutánea inicial y vasculitis, daño renal, cardiovascular, pulmonar e infecciones; en los adultos predominan afecciones articulares y falla renal crónica. Los niños reciben mayor número de fármacos y su mortalidad es mayor.

Lupus among Asians and Hispanics

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... this? Submit What's this? Submit Button Past Emails Lupus among Asians and Hispanics Recommend on Facebook Tweet ... compared with white women. Signs and Symptom of Lupus Lupus can affect people of all ages. However, ...

Diet and Nutrition With Lupus

Science.gov (United States)

... Facebook Pinterest Email Print Diet and nutrition with lupus Lupus Foundation of America April 19, 2018 Resource ... living Recipe collection Guidance on alcohol use with lupus Moderate use of alcohol is usually not a ...

Genes del receptor variable beta de células T en células circulantes de pacientes con lupus eritematoso generalizado y sus familiares sanos.

Science.gov (United States)

Jakez-Ocampo, Juan; Paulín-Vera, Carmen María; Rivadeneyra-Espinoza, Liliana; Gómez-Martín, Diana; Carrillo-Maravilla, Eduardo; Lima, Guadalupe; Vargas-Rojas, María Inés; Pérez-Romano, Beatriz; Calva-Cevenini, Gabriella; García-Carrasco, Mario; Ruiz-Argüelles, Alejandro; Llorente, Luis

Se investigó la proporción de la expresión génica del receptor variable beta de células T (Vβ TCR) en linfocitos periféricos CD3+ en pacientes con lupus eritematoso generalizado (LEG) familiar y no familiar. El repertorio de Vβ TCR se estudió en 14 familias que presentaban más de un miembro con LEG. El uso de Vβ TCR en pacientes con LEG (n = 27) se comparó con el de los miembros sanos de estas familias (n = 47), con 37 pacientes con LEG esporádico y con 15 controles sanos. La expresión del repertorio de Vβ TCR se estudió por citometría de flujo multiparamétrica utilizando un arreglo de 24 diferentes anticuerpos monoclonales específicos de genes familiares para Vβ TCR. Se encontró el mismo perfil de expresión en las comparaciones entre los casos de LEG esporádico y familiar, así como en los consanguíneos sanos de las familias multicasos, que incluía una expresión incrementada de Vβ 5.2, Vβ 11 y Vβ 16, y una menor expresión de Vβ 3, Vβ4, Vβ 7.1 y Vβ 7. De manera interesante, solo Vβ 17 se expresó de modo diferente entre casos familiares y esporádicos de LEG. Igualmente, la expresión incrementada de Vβ 9 fue el distintivo entre los casos de LEG familiar (casos y consanguíneos sanos) y los controles sanos. Estos resultados refuerzan la noción de que el perfil final del repertorio Vβ TCR observado en LEG familiar y no familiar parece surgir de la interacción de factores genéticos, ambientales e inmunorreguladores, además de que pueden explicar las alteraciones inmunitarias que se observan en los consanguíneos sanos de pacientes con LEG. Copyright: © 2018 SecretarÍa de Salud

Comorbilidad y hospitalización en pacientes con lupus eritematoso sistémico. Clínica Universitaria Bolivariana, Congregación Mariana y Hospital Pablo Tobón Uribe, Medellín, 2001

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Martha Herrera

2001-04-01

Full Text Available

El lupus eritematoso sistémico (LES es una enfermedad del
tejido conectivo caracterizada por formación de anticuerpos y complejos inmunes. Compromete cualquier órgano o sistema. Afecta principalmente a mujeres, con mayor incidencia entre la segunda y quinta décadas de la vida.
En Estados Unidos la incidencia es de 1.8-7.6 por 100.000
habitantes por año y la prevalencia oscila entre 15-50 por 100.000 habitantes (1, 2. El lupus genera altos costos institucionales, debido no sólo a la enfermedad en sí, sino también a las complicaciones y a las enfermedades
comórbidas. El estudio permitirá conocer las comorbilidades
presentadas en estas tres instituciones, para un adecuado enfoque e intervención temprana de la misma, que se reflejará en una disminución de costos institucionales y mejor calidad de vida de los pacientes.

Living with Lupus (For Parents)

Science.gov (United States)

... Videos for Educators Search English Español Living With Lupus KidsHealth / For Parents / Living With Lupus What's in ... disease for both doctors and their patients. About Lupus A healthy immune system produces proteins called antibodies ...

Incidence of systemic lupus erythematosus and lupus nephritis in Denmark

DEFF Research Database (Denmark)

Hermansen, Marie-Louise From; Lindhardsen, Jesper; Torp-Pedersen, Christian

2016-01-01

Objective. To determine the incidence of systemic lupus erythematosus (SLE) and SLE with concomitant or subsequent lupus nephritis (LN) in Denmark during 1995.2011, using data from the Danish National Patient Registry (NPR).  Methods. To assess the incidence of SLE, we identified all persons aged...

La productividad total de factores en el sector manufacturero chileno

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Claudio Candia

2016-12-01

Full Text Available Este artículo analiza el cambio en la productividad total de factores del sector manufacturero chileno estimando el índice de Malmquist del periodo 1998-2010. El análisis envolvente de datos permite calcular este índice para determinar el cambio de la PTF y descomponerlo en eficiencia técnica y cambio tecnológico. Los resultados indican que en este periodo la PTF se redujo debido principalmente al cambio tecnológico, mientras que la eficiencia técnica se mantuvo constante.

Historia del Lupus

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Alvaro Rodríguez Gama

2004-09-01

Se encontrarán los lectores con una gran cantidad y calidad de biografías sobre investigaciones, médicos y científicos que han enfrentado el reto de tratar de entender y tratar el lupus, desde los médicos clásicos como Hipócrates, Galeno y Celso, los protodermatólogos Daniel Turner, Jean Astruc, Antoine Lorry y Josef von Plenk; el primer dematológo Robert Willam y médicos de los siglos XVIII y XIX como Thomas Bateman, Jean Lous Alibert, Theódore Biett, Olive Rayer, Pierre Cazenave, Antoine Bazin, Ferdinand von Hebra, Moriz Kaposi, Ernest Besnier, Alfred Fournier, Louis Brocq, Jean Darier, el clasificador Jonathan Hutchinson, Paul Unna, William Osler, Emanuel Libman, George Baehr y así decenas de colosos de la ciencia médica, cuyas historias son descritas minuciosamente por el Dr. Iglesias...

Representaciones sociales en torno al “conflicto” estado chileno - pueblo mapuche en jóvenes universitarios chilenos: un estudio con redes semánticas naturales

Directory of Open Access Journals (Sweden)

Marianela Denegri Coria

2015-01-01

Full Text Available Esta investigación tuvo como propósito realizar una primera aproxi - mación a las representaciones sociales sobre el “conflicto estado-nación y pueblo mapuche”, en estudiantes universitarios del área de Ciencias Sociales de una universidad estatal del sur de Chile. Se trabajó con la técnica de redes semánticas naturales, utilizando cuatro frases- estímulo. Los resultados indican que existe una percepción de la circunstancia en la que se resalta la situación de conflicto, con una mirada muy negativa con respecto al gobierno, el sistema judicial, y los medios de comunicación. Se discuten las implicancias para el futuro desempeño profesional de estos estudiantes en caso de desen - volverse en un contexto laboral de intervención directa o indirecta en este conflicto.

La circulación de las ideas y la inserción de los cientistas económico-sociales chilenos en las redes conosureñas durante los largos 1960

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Eduardo Devés Valdés

2004-12-01

Full Text Available El tema de este artículo, la circulación de las ideas (a través hacia y desde Chile en los largos 60, es una manera de modular dos problemas teóricos que se entrelazan: cuáles fueron las redes intelectuales a las que se articularon los intelectuales chilenos y cómo circulan las ideas en el mundo periférico. Dialogando con diferentes intérpretes del pensamiento chileno y latinoamericano de la época, se intenta elaborar un modelo que trascienda (no que niegue ni menos que ignore la noción colonial-colonialista de influencia desde el pensamiento central. Los objetivos específicos del trabajo son dos: determinar entre los cientistas económico-sociales chilenos o residentes cuáles son los 10 con mayor inserción metanacional y, a partir de allí, determinar cuáles son las ideas que ingresaron durante el período, cómo se hibridaron entre ellas y/o con las ya existentes, cómo fueron mutando y dieron origen a otras que salieron, siendo altamente apetecidas en el mercado internacional de las ideas sobre todo dentro de la propia América Latina, pero también en universidades de Europa, incluso del Este, del Caribe anglófono, de Norteamérica incluido Canadá y también África. Se ha pretendido desarrollar este trabajo eidológico (estudio de las ideas en buena medida como una ciencia de la vida acogiendo categorías como genética, nicho, ecosistema, hibridación y mutación, entre otras.The subject of this article _the circulation of ideas to, from and through Chile in the long `60s_ is a way to approach two connected theoretical problems: in what intellectual networks were the Chilean intellectuals inserted and how do ideas circulate in the periphery. A dialog with different representatives of Chilean and Latin American thought in the period should help to create a model that transcends the notion of "colonial-colonialist" influence from the center. The specific objectives of this work are to establish who are the ten social

Conocimientos, actitudes y comportamiento sexual en un grupo de adolescentes chilenos

OpenAIRE

PÉREZ V, RUTH; CID AR, MARCELA; LEPE O, YAZNA; CARRASCO C, CAROLINA

2004-01-01

Introducción: La sexualidad es una de las mayores preocupaciones para el adolescente, su familia y la sociedad. Objetivo: Determinar conocimientos, actitudes y conducta sexuales en un grupo de adolescentes chilenos. Material y métodos: Estudio descriptivo y cuantitativo realizado en la Octava Región de Chile en el año 2003. Se seleccionó una muestra de 398 alumnos de liceos municipales. Se analizaron variables como comportamiento sexual, conocimientos y actitudes sobre sexualidad. Para el aná...

The Pathogenesis of Lupus Nephritis

Science.gov (United States)

Lech, Maciej

2013-01-01

Lupus nephritis is an immune complex GN that develops as a frequent complication of SLE. The pathogenesis of lupus nephritis involves a variety of pathogenic mechanisms. The extrarenal etiology of systemic lupus is based on multiple combinations of genetic variants that compromise those mechanisms normally assuring immune tolerance to nuclear autoantigens. This loss of tolerance becomes clinically detectable by the presence of antinuclear antibodies. In addition, nucleic acids released from netting or apoptotic neutrophils activate innate and adaptive immunity via viral nucleic acid-specific Toll-like receptors. Therefore, many clinical manifestations of systemic lupus resemble those of viral infection. In lupus, endogenous nuclear particles trigger IFN-α signaling just like viral particles during viral infection. As such, dendritic cells, T helper cells, B cells, and plasma cells all contribute to the aberrant polyclonal autoimmunity. The intrarenal etiology of lupus nephritis involves antibody binding to multiple intrarenal autoantigens rather than the deposition of circulating immune complexes. Tertiary lymphoid tissue formation and local antibody production add to intrarenal complement activation as renal immunopathology progresses. Here we provide an update on the pathogenic mechanisms that lead to lupus nephritis and provide the rationale for the latest and novel treatment strategies. PMID:23929771

Graviditetskomplikationer hos en patient med systemisk lupus erythematosus og lupus nefritis

DEFF Research Database (Denmark)

Bisgaard, Helene; Jacobsen, Søren; Tvede, Niels

2014-01-01

A woman with systemic lupus erythematosus (SLE) and lupus nephritis had two pregnancies which both resulted in complications known to be associated with SLE, i.e. late abortion, preterm delivery and pre-eclampsia. We conclude that disease quiescence is important for a successful outcome...

Propiedades psicométricas de la Escala de Satisfacción con la Vida en los Estudiantes (SLSS de Huebner en niños y niñas de 10 a 12 años de Chile

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Jaime Alfaro

Full Text Available Este trabajo analiza las propiedades psicométricas de la escala SLSS de Huebner en una muestra de niños y niñas chilenos. Se aplicó a 1096 estudiantes de 10 a 12 años (M=11; DT= 0.89 que asistían a establecimientos municipales, particulares subvencionados y particulares pagados en las ciudades de Santiago, Valparaíso y Concepción. Se realizaron análisis de fiabilidad de consistencia interna, análisis factorial exploratorio (AFE y confirmatorio (AFE. Los resultados exhiben una aceptable fiabilidad en tanto consistencia interna de la escala (α=.86, el análisis factorial arroja dos factores en la estructura factorial de la escala que se corresponden con satisfacción con la vida y deseo de cambio. Se discute la solución bifactorial del modelo seleccionado en tanto no se corresponde con lo comunmente reportado en otras investigaciones. El estudio reporta resultados del uso de SLSS en población infantil y aporta al uso y desarrollo de herramientas de medición de autorreporte para el estudio del bienestar subjetivo en niños chilenos.

Matemática y Publicidad: Una experiencia con datos reales

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Danilo Díaz Levicoy

2016-04-01

Full Text Available En este artículo se presentan los resultados de una experiencia de aula, con estudiantes de secundaria, centrado en análisis del Índice de Masa Corporal (IMC de los estudiantes de un colegio chileno y la creación de afiches publicitarios a partir de esta información. Entre los resultados se destacan: la importancia de innovar en la enseñanza de la matemática; los proyectos estadísticos como elementos que favorecen el aprendizaje y el trabajo en equipo; la aplicabilidad de la matemática en la creación de publicidad; la potenciación de habilidades no matemáticas.

Oral manifestations of lupus.

Science.gov (United States)

Menzies, S; O'Shea, F; Galvin, S; Wynne, B

2018-02-01

Mucosal involvement is commonly seen in patients with lupus; however, oral examination is often forgotten. Squamous cell carcinoma arising within oral lupoid plaques has been described, emphasizing the importance of identifying and treating oral lupus. We undertook a retrospective single-centre study looking at oral findings in patients attending our multidisciplinary lupus clinic between January 2015 and April 2016. A total of 42 patients were included. The majority of patients were female (88%) and had a diagnosis of discoid lupus erythematosus (62%). Half of the patients had positive oral findings, 26% had no oral examination documented, and 24% had documented normal oral examinations. Our findings suggest that oral pathology is common in this cohort of patients. Regular oral examination is warranted to identify oral lupus and provide treatment. Associated diseases such as Sjogren's syndrome may also be identified. Patients should be encouraged to see their general dental practitioners on a regular basis for mucosal review. Any persistent ulcer that fails to respond to treatment or hard lump needs urgent histopathological evaluation to exclude malignant transformation to squamous cell carcinoma.

BERTAHAN DENGAN LUPUS: GAMBARAN RESILIENSI PADA ODAPUS

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Anggun Resdasari Prasetyo

2015-01-01

Full Text Available Abstract Lupus is a chronic, autoimmune disease in which an abnormal immune system can cause inflammation on several organ or body systems. The risk of mortality rate caused by Lupus is high and late diagnosis is also prevalent which impact the psychological aspect of individual affected with Lupus (so-called Odapus. Therefore, resiliency is needed; that is individual ability to survive and keep optimistic attitude towards recovery. This study aims to describe the resiliency of the affected individuals with Lupus. This is a qualitative study. Eight persons affected with Lupus who were still coping with Lupus participated in this study. The results indicated that subjects developed a negatives constructs to adapt with Lupus. Therefore, psychological intervention is needed to improve their resiliency.

B cell signature during inactive systemic lupus is heterogeneous: toward a biological dissection of lupus.

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Jean-Claude Garaud

Full Text Available Systemic lupus erythematosous (SLE is an autoimmune disease with an important clinical and biological heterogeneity. B lymphocytes appear central to the development of SLE which is characterized by the production of a large variety of autoantibodies and hypergammaglobulinemia. In mice, immature B cells from spontaneous lupus prone animals are able to produce autoantibodies when transferred into immunodeficient mice, strongly suggesting the existence of intrinsic B cell defects during lupus. In order to approach these defects in humans, we compared the peripheral B cell transcriptomas of quiescent lupus patients to normal B cell transcriptomas. When the statistical analysis is performed on the entire group of patients, the differences between patients and controls appear quite weak with only 14 mRNA genes having a false discovery rate ranging between 11 and 17%, with 6 underexpressed genes (PMEPA1, TLR10, TRAF3IP2, LDOC1L, CD1C and EGR1. However, unforced hierarchical clustering of the microarrays reveals a subgroup of lupus patients distinct from both the controls and the other lupus patients. This subgroup has no detectable clinical or immunological phenotypic peculiarity compared to the other patients, but is characterized by 1/an IL-4 signature and 2/the abnormal expression of a large set of genes with an extremely low false discovery rate, mainly pointing to the biological function of the endoplasmic reticulum, and more precisely to genes implicated in the Unfolded Protein Response, suggesting that B cells entered an incomplete BLIMP1 dependent plasmacytic differentiation which was undetectable by immunophenotyping. Thus, this microarray analysis of B cells during quiescent lupus suggests that, despite a similar lupus phenotype, different biological roads can lead to human lupus.

Genetics Home Reference: systemic lupus erythematosus

Science.gov (United States)

... Twitter Home Health Conditions Systemic lupus erythematosus Systemic lupus erythematosus Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Systemic lupus erythematosus (SLE) is a chronic disease that causes inflammation ...

The serum levels of connective tissue growth factor in patients with systemic lupus erythematosus and lupus nephritis.

Science.gov (United States)

Wang, F-M; Yu, F; Tan, Y; Liu, G; Zhao, M-H

2014-06-01

The expression of connective tissue growth factor mRNA in human kidneys may serve as an early marker for lupus nephritis progression. Therefore, we speculated that connective tissue growth factor may be involved in the pathogenesis of systemic lupus erythematosus and lupus nephritis. In this study, we set out to investigate the associations between serum connective tissue growth factor levels and clinicopathological features of patients with systemic lupus erythematosus and lupus nephritis. Serum samples from patients with non-renal systemic lupus erythematosus, renal biopsy-proven lupus nephritis and healthy control subjects were detected by enzyme-linked immunosorbent assay for serum connective tissue growth factor levels. The associations between connective tissue growth factor levels and clinicopathological features of the patients were further analysed. The levels of serum connective tissue growth factor in patients with non-renal systemic lupus erythematosus and lupus nephritis were both significantly higher than those in the normal control group (34.14 ± 12.17 ng/ml vs. 22.8 ± 3.0 ng/ml, plupus erythematosus and lupus nephritis group (34.14 ± 12.17 ng/ml vs. 44.1 ± 46.8 ng/ml, p = 0.183). Serum connective tissue growth factor levels were significantly higher in lupus nephritis patients with the following clinical manifestations, including anaemia (51.3 ± 51.4 ng/ml vs. 23.4 ± 9.7 ng/ml, plupus nephritis (63.3 ± 63.4 ng/ml vs. 38.3 ± 37.9 ng/ml, p = 0.035, respectively). Serum connective tissue growth factor levels were negatively associated with estimated glomerular filtration rate (r = -0.46, plupus nephritis (plupus and correlated with chronic renal interstitial injury and doubling of serum creatinine in patients with lupus nephritis. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Ectopic Axillary Breast during Systemic Lupus

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Besma Ben Dhaou

2012-01-01

Full Text Available Many breast changes may occur in systemic lupus erythematosus. We report a 41-year-old woman with lupus who presented three years after the onset of lupus an ectopic mammary gland confirmed by histological study.

Prevalencia de anticuerpos antifosfolípidos en pacientes con conectivopatías

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Óscar Emilio Ruiz-Franco

2011-07-01

Full Text Available Objetivos: Determinar la prevalencia de anticuerpos antifosfolípidos en pacientes con conectivopatías. Diseño: Estudio descriptivo transversal. Institución: Hospital Dos de Mayo e Instituto de Investigaciones Clínicas de la UNMSM, Lima, Perú. Participantes: Pacientes con diagnóstico de colagenopatía y sujetos sanos. Intervenciones: En 100 pacientes con diagnóstico de colagenopatía y 50 sujetos sanos, todos provenientes de Lima Metropolitana y atendidos entre enero y noviembre de 2008, se determinó fibrinógeno, tiempo de protrombina, tiempo parcial de tromboplastina activada, anticuerpos anticardiolipina y anticoagulante lúpico. Principales medidas de resultados: Presencia de anticuerpos anticardiolipina y anticoagulante lúpico. Resultados: Los pacientes con conectivopatías presentaron anticuerpos antifosfolípidos en 17%, anticoagulante lúpico en 13% y anticardiolipina IgG 4%. Al dividir el grupo por conectivopatías, en los 70 pacientes con lupus eritematoso sistémico 10 resultaron positivos para anticoagulante lúpico y 3 tuvieron anticardiolipina IgG; de los 30 pacientes con artritis reumatoide, 3 tuvieron anticoagulante lúpico positivo y 1 presentó anticardiolipina IgG. En el grupo de 50 personas sanas, solo se encontró un caso positivo para anticoagulante lúpico. Conclusiones: La prevalencia de anticuerpos antifosfolípidos en pacientes con conectivopatías fue 17%. La conectivopatía estudiada más frecuente fue el lupus eritematoso sistémico. El anticuerpo antifosfolípido más frecuente fue el anticoagulante lúpico.

EL CONVENIO REGULADOR EN EL DERECHO ESPAÑOL Y EL PROYECTO DE LEY DE MATRIMONIO CIVIL CHILENO

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Rodrigo Barcia Lehmann

2002-01-01

Full Text Available Este trabajo analiza el convenio regulador en el Derecho español con miras a confrontar algunos aspectos de éste con el Proyecto de Ley de Matrimonio Civil chileno. El análisis del Derecho español presenta interesantes discusiones en torno a la naturaleza del convenio regulador previo a su homologación, naturaleza de la sentencia que lo homologa, los efectos del convenio regulador respecto de los terceros, y presenta una serie de matices con relación a los cónyuges y a los hijos. Con relación a aquéllos se restringe la intervención del Juez lo que no acontece respecto de los hijos. Después de concluir este trabajo se hace patente que el Proyecto de Ley de Matrimonio Civil peca de un exceso paternalista y es muy poco respetuoso de las decisiones de los cónyuges, además de conceder un ámbito de aplicación al convenio mucho más restringido que el Derecho español.This paper analyzes the legalization agreement in the Spanish Law with the purpose of confronting some of its aspects with the Chilean Civil Marriage Law Project. The analysis of the Spanish Law presents interesting discussions dealing with the nature of the legalization agreement prior to its ratification, the nature of the verdict that ratifies it, the effects of the legalization agreement with respect to others, and a series of guidelines in relation with the married couple and the children. The intervention of a judge is restricted concerning the couple but not in the case of the children. After concluding this paper it is clear that the Civil Marriage Law Project is too paternal and has little respect for the decisions of the couple, in addition it bestows an application limit to the agreement, which is much more restrictive than the Spanish Law.

Pregnancy complications in a patient with systemic lupus erythematosus and lupus nephritis

DEFF Research Database (Denmark)

Bisgaard, Helene; Jacobsen, Søren; Tvede, Niels

2014-01-01

A woman with systemic lupus erythematosus (SLE) and lupus nephritis had two pregnancies which both resulted in complications known to be associated with SLE, i.e. late abortion, preterm delivery and pre-eclampsia. We conclude that disease quiescence is important for a successful outcome...

Teatro chileno y anarquismo (desde comienzos de siglo XX hasta el período dictatorial Chilean Theatre and Anarchism (from the beginning of 20th century to the dictatorship

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Sara Rojo

2008-12-01

Full Text Available Este estudio analiza la relación entre el pensamiento anarquista y el teatro en Chile desde comienzos de siglo hasta el período de la dictadura militar. Comienza con un recorte teórico del concepto de anarquismo dentro del marco histórico chileno, para posteriormente analizar, de manera cronológica, producciones teatrales específicas del período anteriormente citado.This study analyzes the relationship between anarchist thinking and theatre in Chile from the beginning of the century up to the time of the military dictatorship. It begins with a theoretical highlight of the concept of anarchism in Chilean history and later chronologically analyzes theater plays that are specific to the abovementioned period.

Roberto Bolaño, la memoria antiheroica del exilio chileno

OpenAIRE

Carreras Rabasco, Adrián

2011-01-01

Este artículo se centra en la personalidad del escritor chileno Roberto Bolaño y su obra para profundizar en la relación existente entre el autor y Chile, su país de origen. Pese a haber abandonado el país siendo muy joven y a haber residido en otros países a lo largo de su vida, Bolaño nunca perdió el interés por recuperar sus raíces chilenas tanto como lo reflejan las novelas que dedica a la dictadura chilena, Estrella distante y Nocturno de Chile sobre todo, así como por reivindicar su pro...

Childhood-onset bullous systemic lupus erythematosus.

Science.gov (United States)

Lourenço, D M R; Gomes, R Cunha; Aikawa, N E; Campos, L M A; Romiti, R; Silva, C A

2014-11-01

Bullous systemic lupus erythematosus has rarely been described in pediatric lupus population and the real prevalence of childhood-onset bullous systemic lupus erythematosus has not been reported. From January 1983 to November 2013, 303 childhood-onset SLE (c-SLE) patients were followed at the Pediatric Rheumatology Unit of the Childreńs Institute of Hospital das Clínicas da Faculdade de Medicina Universidade da Universidade de São Paulo, three of them (1%) diagnosed as childhood-onset bullous systemic lupus erythematosus. All three cases presented tense vesiculobullous lesions unassociated with lupus erythematosus lesions, with the median duration of 60 days (30-60). All patients fulfilled bullous systemic lupus erythematosus criteria. Two had nephritis and serositis and presented specific autoantibodies. The histological pattern demonstrated subepidermal blisters with neutrophils-predominant infiltrates within the upper dermis. Direct immunofluorescence (DIF) showed deposits of IgG and complement along the epidermal basement membrane, in the presence or absence of IgA and/or IgM. A positive indirect immunofluorescence on salt-split skin demonstrating dermal binding was observed in two cases. All of them had moderate/severe disease activity at diagnosis with median Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) of 18 (14-24). Two patients received dapsone and one with severe nephritis received immunosuppressive drugs. In conclusion, in the last 30 years the prevalence of bullous lupus in childhood-onset lupus population was low (1%) in our tertiary University Hospital. A diagnosis of SLE should always be considered in children with recurrent tense vesiculobullous lesions with or without systemic manifestations. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Epidemiology of cutaneous lupus erythematosus and the associated risk of systemic lupus erythematosus

DEFF Research Database (Denmark)

Petersen, M Prütz; Möller, S; Bygum, A

2018-01-01

Objectives The objectives of this paper are to describe the epidemiology of cutaneous lupus erythematosus (CLE) and its subtypes in Denmark, and to investigate the probability of receiving a subsequent diagnosis of systemic lupus erythematosus (SLE) and the related time course. Methods A nationwide...

Xenofobia y Homofobia como Efectos de la Orientación Política, Religión y Sexo Mediados por Clasismo y Patriocentrismo en Jóvenes Universitarios Chilenos

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Fuad Hatibovic Díaz

2017-02-01

Full Text Available La presente investigación examina, en estudiantes universitarios chilenos, la relación entre xenofobia, homofobia y las variables: sexo, religión y orientación política. También se evalúa el papel mediador del clasismo y patriocentrismo en la relación entre las variables sociodemográficas y la xenofobia y homofobia. Se utilizó metodología cuantitativa con diseño descriptivo correlacional. Los participantes fueron 509 estudiantes, con promedio de 20.81 años de edad (dt=2.25. Se utilizó un cuestionario abreviado basado en la Encuesta de Tolerancia y No Discriminación. Los análisis de varianza mostraron que existen diferencias significativas en función de sexo, religión y orientación política. Las mujeres obtuvieron puntajes significativamente menores que los hombres en homofobia; las personas no religiosas y de izquierda obtuvieron menores puntuaciones en todas las dimensiones analizadas, comparado con las personas religiosas y de derecha. Los análisis de mediación múltiple mostraron que las variables mediadoras explican esas diferencias en la homofobia y la xenofobia.

Increased risk of depression in patients with cutaneous lupus erythematosus and systemic lupus erythematosus

DEFF Research Database (Denmark)

Hesselvig, J H; Egeberg, A; Kofoed, K

2018-01-01

BACKGROUND: Reported prevalences of depression in patients with systemic lupus erythematosus (SLE) range widely, while the prevalence of depression in cutaneous lupus erythematosus (CLE) remains severely understudied. OBJECTIVES: To examine whether patients with SLE or CLE have increased risk...... of primary and secondary care, analyses of risk for depression and antidepressant use were performed in Cox regression models adjusted for age, sex, socio-economic status, smoking, alcohol abuse, prior depression, and prior antidepressant use. RESULTS: A total of 3,489 patients with lupus erythematosus were...

Treatment of Cutaneous Lupus Erythematosus

Science.gov (United States)

Kim, Grace K.; Del Rosso, James Q.

2013-01-01

The treatment of cutaneous lupus erythematosus is centered upon formulating a regimen of topical and systemic therapies designed to reduce disease activity and minimize cosmetic damage. Sun avoidance and sunscreen are important preventative measures proven to minimize cutaneous lupus erythematosus exacerbations. Limited disease is typically managed with topical corticosteroids or calcineurin inhibitors. Antimalarial therapy is the gold standard of systemic therapy. Many other treatments have been studied in patients with recalcitrant cutaneous lupus erythematosus, and their use must be evaluated based on individual risk-benefit concerns. R-salbutamol and pulsed dye laser therapy have proven to be effective topical alternatives. Additional systemic agents include retinoids, immunosuppressants, immunomodulators, biologics, and other experimental therapies with novel modes of action. According to the Oxford Centre for Evidence-based Medicine criteria for evaluating the strength of evidence supporting an individual treatment measure, no therapy for cutaneous lupus erythematosus has achieved Level 1 status. This demonstrates the need for randomized, controlled trials and systematic reviews of all cutaneous lupus erythematosus interventions in order to meet increasing standards and demand for evidence-based practice. PMID:23320123

An unusual presentation of juvenile lupus nephritis

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Malleshwar Bottu

2016-01-01

Full Text Available The incidence of juvenile lupus varies widely ranging between 4 and 250 per 100,000 population. Most common organ involvement in juvenile lupus is kidney. Neurological, cutaneous and hematological involvements are also involved. Skeletal muscle involvement in the form of myositis is rare. Myositis as presenting manifestation in juvenile lupus is also unusual. Herein, we report one such case wherein myositis preceded the onset of lupus nephritis

Gut Microbiota in Human Systemic Lupus Erythematosus and a Mouse Model of Lupus.

Science.gov (United States)

Luo, Xin M; Edwards, Michael R; Mu, Qinghui; Yu, Yang; Vieson, Miranda D; Reilly, Christopher M; Ahmed, S Ansar; Bankole, Adegbenga A

2018-02-15

Gut microbiota dysbiosis has been observed in a number of autoimmune diseases. However, the role of the gut microbiota in systemic lupus erythematosus (SLE), a prototypical autoimmune disease characterized by persistent inflammation in multiple organs of the body, remains elusive. Here we report the dynamics of the gut microbiota in a murine lupus model, NZB/W F1, as well as intestinal dysbiosis in a small group of SLE patients with active disease. The composition of the gut microbiota changed markedly before and after the onset of lupus disease in NZB/W F1 mice, with greater diversity and increased representation of several bacterial species as lupus progressed from the predisease stage to the diseased stage. However, we did not control for age and the cage effect. Using dexamethasone as an intervention to treat SLE-like signs, we also found that a greater abundance of a group of lactobacilli (for which a species assignment could not be made) in the gut microbiota might be correlated with more severe disease in NZB/W F1 mice. Results of the human study suggest that, compared to control subjects without immune-mediated diseases, SLE patients with active lupus disease possessed an altered gut microbiota that differed in several particular bacterial species (within the genera Odoribacter and Blautia and an unnamed genus in the family Rikenellaceae ) and was less diverse, with increased representation of Gram-negative bacteria. The Firmicutes / Bacteroidetes ratios did not differ between the SLE microbiota and the non-SLE microbiota in our human cohort. IMPORTANCE SLE is a complex autoimmune disease with no known cure. Dysbiosis of the gut microbiota has been reported for both mice and humans with SLE. In this emerging field, however, more studies are required to delineate the roles of the gut microbiota in different lupus-prone mouse models and people with diverse manifestations of SLE. Here, we report changes in the gut microbiota in NZB/W F1 lupus-prone mice and a

El consumo de noticias de los adolescentes chilenos: intereses, motivaciones y percepciones sobre la agenda informativa

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Ana Rayén Condeza Dall’Orso

2014-07-01

Full Text Available En un contexto de proliferación de medios y creciente acceso a diversos contenidos mediáticos, se vuelve necesario examinar las motivaciones de las audiencias jóvenes para consumir información. El estudio de este grupo etario es relevante, dado que la adolescencia es un período fundamental en la socialización cívica de las personas. Esta investigación explora cómo chilenos de 13 a 17 años consumen noticias, en un contexto mediático de múltiples soportes, convergencia y cultura móvil. Pocos estudios se centran en los hábitos informativos de este grupo específico. A partir de un cuestionario cuantitativo autoaplicado en 2013 a 2.273 adolescentes en establecimientos educativos de cuatro regiones del país, se analizan sus hábitos de consumo, interés en las noticias, percepción sobre la importancia de los temas de la agenda y motivaciones informativas. Los resultados muestran que los jóvenes encuestados se informan principalmente a través de redes sociales como Facebook, en detrimento de los medios convencionales. El tema que menos les interesa es la política tradicional, que, a su juicio, es el que más aparece en las noticias. Sus motivaciones en el consumo informativo se relacionan con el deseo de defender sus puntos de vista y de transmitir información a otros. Además, estiman que su representación en la agenda informativa es inadecuada y negativa. Estos resultados sugieren una deuda pendiente de la industria informativa con los jóvenes.

RELACIÓN ENTRE ATRIBUCIONES DE ÉXITO Y FRACASO ACADÉMICO Y ANSIEDAD ESCOLAR EN ESTUDIANTES CHILENOS DE EDUCACIÓN SECUNDARIA

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Nelly Gromiría Lagos San Martín

2016-01-01

Full Text Available El objetivo de este estudio fue comprobar la relación entre las atribuciones de éxito y fracaso académico en Lenguaje y Matemáticas, y la ansiedad escolar en estudiantes de educación secundaria chilenos. Participaron 1314 estudiantes de 15 establecimientos de la provincia de Ñuble, en Chile, cuyo rango de edad osciló entre 13 y 17 años (M = 15.55; DE = 1.32. La Ansiedad Escolar se evaluó con el Inventario de Ansiedad Escolar (IAES, y las atribuciones causales con la Sydney Attribution Scale (SAS. Los resultados mostraron que los estudiantes que atribuyeron menos sus éxitos y fracasos a causas externas en Lenguaje obtuvieron medias más altas de ansiedad escolar. Por otro lado, presentaron mayor ansiedad escolar los sujetos que atribuyeron menos sus éxitos a la capacidad en Matemáticas y más sus fracasos a la falta de capacidad tanto en Matemáticas como en Lenguaje. Por último, los estudiantes que atribuyeron más sus éxitos al esfuerzo en Lenguaje mostraron puntuaciones medias más altas en ansiedad escolar. Se concluye que los datos corroboran hallazgos anteriores y alertan acerca de la necesidad de atender estas problemáticas en los procesos pedagógicos.

La cultura nacional y su impacto en los negocios: el caso chileno

OpenAIRE

Pedro Hidalgo Campos; Enrique Manzur Mobarec; Sergio Olavarrieta Soto; Pablo Farías Nazel

2007-01-01

El objetivo de este artículo es analizar el impacto de la cultura nacional en los negocios. Uno de los investigadores más destacados en el análisis de la cultura nacional es Geert Hofstede (1980). Él identificó cuatro dimensiones de la cultura nacional: distancia de poder, aversión a la incertidumbre, individualismo y masculinidad. Fernández et al. (1997) midieron estas cuatro dimensiones en Chile, caracterizando a los chilenos en esas cuatro dimensiones. Revisando la evidencia empírica chile...

Cutaneous lupus erythematosus and systemic lupus erythematosus are associated with clinically significant cardiovascular risk

DEFF Research Database (Denmark)

Hesselvig, J Halskou; Ahlehoff, O; Dreyer, L

2017-01-01

Systemic lupus erythematosus (SLE) is a well-known cardiovascular risk factor. Less is known about cutaneous lupus erythematosus (CLE) and the risk of developing cardiovascular disease (CVD). Therefore, we investigated the risk of mortality and adverse cardiovascular events in patients diagnosed...

Solidaridad en el debate global y local: reflexión desde un análisis del caso chileno

Directory of Open Access Journals (Sweden)

José Antonio Román-Brugnoli

2014-01-01

Full Text Available En los últimos quince años la noción de solidaridad ha vuelto al debate en las ciencias sociales, obligando a una reflexión transdisciplinar. Este debate se ha centrado en las democracias modernas liberales en el contexto de la globalización del libre mercado, caracterizándose por tres preocupaciones principales: gobernabilidad, responsabilidad y cohesión social; el papel que la solidaridad juega y puede desempeñar en el decurso de este proceso; y respecto de las mutaciones mismas de la solidaridad. Este artículo contribuye en esta reflexión desde un análisis del caso chileno, cuyo interés particular radica en su reciente proceso de recuperación de una política de derechos sociales, y en el protagonismo que la noción de solidaridad ha tenido dentro de éste. Para ello aporta datos propios de análisis de la política social de los últimos cuatro gobiernos democráticos, la publicidad sobre solidaridad y la opinión pública, los cuales son comparados con resultados de otros estudios.

THE CAROLINA LUPUS STUDY (CLU)

Science.gov (United States)

Carolina Lupus (CLU) Study, an epidemiologic study of risk factors for systemic lupus erythematosus (SLE). SLE is a severe, chronic, systemic autoimmune disease that disproportionately affects women and African-Americans. The CLU Study focuses on measures of endogenous hormone ex...

A rare case of unilateral discoid lupus erythematosus mimicking lupus vulgaris.

Science.gov (United States)

Verma, Parul; Pathania, Sucheta; Kubba, Asha

2017-11-08

Discoidlupus erythematosus (DLE) is a chronic type of cutaneous lupus erythematosus which can present in various morphologies, and the diagnosis can be rather confounding. Prompt evaluation and treatment is necessary to prevent disfigurement and systemic involvement associated with DLE. The following case presented a diagnostic dilemma as the lesion mimicked lupus vulgaris. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Lupus mastitis - peculiar radiological and pathological features

International Nuclear Information System (INIS)

Wani, Abdul Majid; Hussain, Waleed Mohd; Fatani, Mohamed I; Shakour, Bothaina Abdul

2009-01-01

Lupus mastitis is a form of lupus profundus that is seen in patients with systemic lupus erythematosus. It usually presents as a swelling (or swellings) in the breasts, with or without pain. The condition is recurrent and progresses along with the underlying disease, with fat necrosis, calcification, fibrosis, scarring, and breast atrophy. Lupus mastitis is often confused with malignancy and lymphoma and, in our part of the world, with tuberculosis. Confusion is especially likely when it occurs in an unusual clinical setting. In this article, we present a case that presented with unique radiological, pathological, and clinical features. Awareness of the various manifestations of lupus mastitis is essential if unnecessary interventions such as biopsies and surgeries, and their consequences, are to be avoided

Pro: Cyclophosphamide in lupus nephritis

NARCIS (Netherlands)

Kallenberg, Cees G. M.

Based on efficacy and toxicity considerations, both low-dose pulse cyclophosphamide as part of the Euro-Lupus Nephritis protocol and mycophenolate mofetil (MMF) with corticosteroids may be considered for induction of remission in patients with proliferative lupus nephritis. The long-term follow-up

multiniveles de demanda. Un caso ilustrativo chileno

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Fernando Rojas Zúñiga

2015-01-01

Full Text Available El sistema de abastecimiento de medicamentos en atención primaria de salud en Chile posee un únicoproveedor a nivel nacional y no considera multiniveles de demanda para el cálculo del aprovisionamiento,generando superávit de inventario. El presente trabajo propone una política de abastecimiento de revisiónperiódica mediante un pronóstico probabilístico de demanda, modelando su estructura de dependenciaen forma individual y mediante cópulas bivariadas, coordinando los multiniveles y minimizando loscostos. El estudio se llevó a cabo en una muestra de 104 medicamentos abastecidos durante 3 a˜nos en uncentro de salud familiar chileno. Los resultados generados muestran que la política propuesta disminuiríasemanalmente en un 8,22% los costos de compra, en un 95,47% los costos de ordenar y en un 54,6% loscostos totales.© 2015 Universidad ICESI. Publicado por Elsevier España, S.L.U. Este es un artículo Open Access bajo lalicencia CC BY (http://creativecommons.org/licenses/by/4.0/.

Antiphospholipid antibodies and non-thrombotic manifestations of systemic lupus erythematosus.

Science.gov (United States)

İlgen, U; Yayla, M E; Ateş, A; Okatan, İ E; Yurteri, E U; Torgutalp, M; Keleşoğlu, A B D; Turgay, T M; Kınıklı, G

2018-04-01

Objectives The aim of this study was to investigate the association between antiphospholipid antibodies and non-thrombotic and non-gestational manifestations of systemic lupus erythematosus. Methods Systemic lupus erythematosus patients with persistently positive antiphospholipid antibodies or lupus anticoagulant were identified and grouped as systemic lupus erythematosus with antiphospholipid syndrome (SLE-APS), systemic lupus erythematosus with positive antiphospholipid antibodies/lupus anticoagulant without antiphospholipid syndrome (SLE-aPL), and systemic lupus erythematosus with negative aPLs (SLE-No aPL). Groups were compared in terms of non-thrombotic systemic lupus erythematosus manifestations and laboratory features retrospectively. Results A total of 150 systemic lupus erythematosus patients, 26 with SLE-APS, 25 with SLE-aPL, and 99 with SLE-No aPL, were identified. Livedo reticularis, neurologic involvement, and thrombocytopenia were more common in antiphospholipid antibody positive systemic lupus erythematosus cases. Malar rash, arthritis, and pleuritis were more common in the SLE-No aPL, SLE-APS, and SLE-aPL groups, respectively. Positivity rates and titers of specific antiphospholipid antibodies did not differ between the SLE-APS and SLE-aPL groups. Conclusions Presence of antiphospholipid syndrome or persistent antiphospholipid antibodies may be related to non-thrombotic and non-gestational systemic lupus erythematosus manifestations. Patients with systemic lupus erythematosus plus antiphospholipid syndrome and persistent antiphospholipid antibodies without antiphospholipid syndrome also differ in terms of systemic lupus erythematosus manifestations.

Fundamentos para un estudio del guion en el cine chileno: notas preliminares

OpenAIRE

Rubén Dittus Benavente

2015-01-01

El artículo presenta el marco teórico para estudiar los modelos de guion en el cine chileno de ficción. La literatura publicada y el creciente interés en la formación de guionistas en la industria audiovisual, tanto en Chile como en el extranjero, dan cuenta de la necesidad de abordar los principios dramatúrgicos y los estándares profesionales desde una mirada integradora, que supere los clásicos modelos de escritura creativa. Más allá de las divergencias o acuerdos de dichas teorías, el guio...

Personas con discapacidad y políticas públicas de inclusión educativa en Chile

Directory of Open Access Journals (Sweden)

Juan Guillermo Estay

2015-06-01

Full Text Available Introducción: Chile se ve enfrentado en la actualidad a un cambio de paradigma en materia educacional. La Reforma Educativa, hasta el momento, no hace mención a la educación de Personas con Discapacidad y Necesidades Educativas Especiales, que de plasmarse en ley, dejaría a Chile -entre un reducido número de países no desarrollados-, con una educación inclusiva consagrada constitucionalmente. Objetivo: Identificar las políticas de educación inclusiva que amparan a las personas con discapacidad en Chile. Metodología: Artículo de revisión. Se realizó una búsqueda de la literatura en la biblioteca nacional de Chile y Google Scholar. Resultados: Se abordaron las temáticas: sistema educativo chileno, normativa internacional en materia de educación inclusiva, normativa chilena sobre inclusión y normativa chilena sobre educación e inclusividad. Conclusión: A pesar de la normatividad sobre discapacidad existente en Chile, no ha existido una verdadera inclusión de las personas con discapacidad y necesidades educativas especiales en el sistema educativo.

Health-related quality of life in patients with systemic lupus erythematosus: development and validation of a lupus specific symptom checklist

NARCIS (Netherlands)

Grootscholten, C.; Ligtenberg, G.; Derksen, R. H. W. M.; Schreurs, K. M. G.; de Glas-Vos, J. W.; Hagen, E. C.; van den Wall Bake, A. W. L.; Huizinga, T. W. J.; van den Hoogen, F. H. J.; Bijl, M.; van Houwelingen, J. C.; Snoek, F. J.; Berden, J. H. M.

2003-01-01

Reliable and sensitive measures are needed to evaluate the quality of life (QoL) in patients with systemic lupus erythematosus (SLE). No lupus specific questionnaires are available. This study describes the development and validation of a disease-specific questionnaire for lupus patients, which

Validation of the LupusPRO version 1.8: an update to a disease-specific patient-reported outcome tool for systemic lupus erythematosus.

Science.gov (United States)

Azizoddin, D R; Weinberg, S; Gandhi, N; Arora, S; Block, J A; Sequeira, W; Jolly, M

2018-04-01

Objectives LupusPRO has shown good measurement properties as a disease-specific patient-reported outcome tool in systemic lupus erythematosus (SLE). For the purpose of clinical trials, the version 1.7 (v1.7) domain of Pain-Vitality was separated into distinct Pain, Vitality and Sleep domains in v1.8, and the psychometric properties examined. Methods A total of 131 consecutive SLE patients were self-administered surveys assessing fatigue (FACIT, SF-36), pain (Pain Inventory, SF-36), insomnia (Insomnia Severity Index), emotional health (PHQ-9, SF-36) and quality of life (SF-36, LupusPRO) at routine care visits. Internal consistency reliability (ICR) for each domain was obtained using Cronbach's alpha. The convergent construct validity of LupusPRO domains with corresponding SF-36 domains or tools were tested using Spearman correlation. Varimax rotations were conducted to assess factor structures of the LupusPRO v1.8. Results Mean (SD) age was 40.04 (14.10) years. Scores from the LupusPRO-Sleep domain strongly correlated with insomnia scores, while LupusPRO-Vitality correlated strongly with fatigue (FACIT) and SF-36 vitality. The LupusPRO-Pain domain correlated strongly with pain (SF36 Bodily-Pain, Pain Inventory) scores. Similarly, the LupusPRO domains of Physical and Emotional Health had significant correlations with corresponding SF-36 domains. The ICR for HRQoL and non-HRQoL were 0.96 and 0.81. LupusPRO (domains HRQoL and QoL) scores correlated with disease activity. Principal component analysis included seven factor loadings presenting for the HRQOL subscales (combined Sleep, Vitality, and Pain), and three factors for the NHRQoL (Combined Coping and Social Support). Conclusions LupusPRO v1.8 (including its Sleep, Vitality, and Pain domains) has acceptable reliability and validity. Use of LupusPRO as an outcome measure in clinical trials would facilitate responsiveness assessment.

El mercado hidrotérmico chileno: un enfoque de teoría de juegos

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Villena Mauricio

2006-12-01

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Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus

DEFF Research Database (Denmark)

Petri, Michelle; Orbai, Ana-Maria; Alarcón, Graciela S

2012-01-01

The Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria in order to improve clinical relevance, meet stringent methodology requirements, and incorporate new...

Dyslipidemia in systemic lupus erythematosus: just another comorbidity?

Science.gov (United States)

Tselios, Konstantinos; Koumaras, Charalambos; Gladman, Dafna D; Urowitz, Murray B

2016-04-01

Among traditional atherosclerotic risk factors, dyslipidemia is believed to decisively affect the long-term prognosis of lupus patients, not only with regard to cardiovascular events but also by influencing other manifestations, such as lupus nephritis. The aim of this study was to review the epidemiology, pathogenesis, evidence for its impact on atherosclerosis manifestations and management of dyslipidemia in lupus patients. English-restricted MEDLINE database search (Medical Subject Headings: lupus or systemic lupus erythematosus and dyslipidemia or hyperlipidemia). The prevalence of dyslipidemia in systemic lupus erythematosus (SLE) ranges from 36% at diagnosis to 60% or even higher after 3 years, depending on definition. Multiple pathogenetic mechanisms are implicated, including antibodies against lipoprotein lipase and cytokines affecting the balance between pro- and anti-atherogenic lipoproteins. Dyslipidemia has a clear impact on clinical cardiovascular disease and surrogate markers for subclinical atherosclerosis. Moreover, it negatively affects end-organ damage (kidneys and brain). Treatment with statins yielded contradictory results as per minimizing cardiovascular risk. Dyslipidemia is a significant comorbidity of lupus patients with multiple negative effects in the long term. Its treatment represents a modifiable risk factor; prompt and adequate treatment can minimize unnecessary burden in lupus patients, thus reducing hospitalizations and their overall morbidity and mortality. Copyright © 2016 Elsevier Inc. All rights reserved.

Estudio de los textos de Historia y de Ciencias Sociales chilenos entre 2000 y 2010 Estudo dos textos de historia e de ciências sociais chilenos entre 2000 e 2010 Study of Chilean History and Social Science Textbooks between 2000 and 2010

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Raquel Soaje-de Elias

2012-04-01

Full Text Available Analizar la calidad de los textos de Historia y de Ciencias Sociales, entregados por el Ministerio de Educación chileno a los estudiantes de establecimientos oficiales y subvencionados, es el objetivo de este trabajo. Se examinaron 35 textos editados entre 2000 y 2010. En la investigación de aplicó una encuesta a docentes de colegios subvencionados y de realizaron cuatro "focusgroup" con docentes de colegios particulares de alta calidad. En el estudio se tuvieron en cuenta las siguientes variables-, estructura y organización, contenido y metodología de los libros y se concluyó que sus contenidos presentan falencias, que se deben revisar para optimizar su uso como herramienta fundamental en el proceso de enseñanza y aprendizaje.Analisar a qualidade dos textos de história e de ciências sociais, entregues pelo Ministério da Educação chileno aos estudantes de estabelecimentos oficiais e subsidiados, é o objetivo deste trabalho. Examinaram-se 35 textos editados entre 2000 e 2010. Na pesquisa se aplicou uma enquête com docentes de colégios subsidiados e se realizaram quatro "focusgroup"com docentes de colégios particulares de alta qualidade. No estudo se consideraram as seguintes variáveis: estrutura e organização, conteúdo e metodología dos livros. Concluiu-se que seus conteúdos apresentam falências que se devem revisar para melhorar seu uso como ferramenta fundamental no processo de ensino e aprendizagem.The objective of this study was to analyze the quality of history and social science textbooks provided by the Chilean Ministry of Education to students at public and subsidized schools. Fifteen (is textbooks published between 2000 and 2010 were examined for that purpose. Teachers at subsidized schools were surveyed and four focus groups were conducted with teachers from several top-rated private schools. The study took into account the following variables-, structure and organization, content and methodology of the textbooks

Prognostic factors in lupus nephritis

DEFF Research Database (Denmark)

Faurschou, Mikkel; Starklint, Henrik; Halberg, Poul

2006-01-01

To evaluate the prognostic significance of clinical and renal biopsy findings in an unselected cohort of patients with systemic lupus erythematosus (SLE) and nephritis.......To evaluate the prognostic significance of clinical and renal biopsy findings in an unselected cohort of patients with systemic lupus erythematosus (SLE) and nephritis....

Estatura de padres e hijos chilenos de diferente etnia y vulnerabilidad social

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Amigo Hugo

2000-01-01

Full Text Available OBJETIVO: Analizar y comparar la estatura de niños que ingresan a la escuela y la de sus padres, de acuerdo con sus antecedentes étnicos y nivel socioeconómico. MATERIAL Y MÉTODOS: Estudio transversal, realizado entre 1997 y 1999, en Santiago y la zona centro-sur de Chile, en 351 escolares indígenas y 531 no indígenas, y sus padres, provenientes de comunas de tres niveles de vulnerabilidad social: muy alta (pobreza, mediana y muy baja. Escolar indígena era el que tenía sus cuatro apellidos mapuches, el no indígena tenía sus cuatro apellidos de origen chileno-español. La estatura se comparó en medidas estandarizadas (puntaje Z utilizando como referencia la medición del cambio nutricional propuesta por la Organización Mundial de la Salud. Se estimaron las diferencias de medias de estatura padres-hijos con análisis de varianza y se determinó el origen de tales diferencias al aplicar el procedimiento de Scheffe. RESULTADOS: Los progenitores en ambas etnias aumentaron sus promedios de estatura al mejorar las condiciones sociales, excepto las madres indígenas que no presentaron incremento significativo. Los padres de la muy alta vulnerabilidad midieron 4 cm menos que los de la muy baja vulnerabilidad y las madres 2 cm menos (p<0.001. En los escolares indígenas hay una gradiente positiva de estatura a medida que mejoran las condiciones sociales (p<0.001, no así en los no indígenas. Al comparar la estatura de progenitores e hijo(as se observa que los escolares presentaron un índice talla/edad mayor que sus padres (p<0.01, especialmente los escolares indígenas que en promedio tuvieron 1.4 puntajes Z más que sus padres. CONCLUSIONES: El incremento de estatura observado al mejorar las condiciones sociales y la mayor adecuación de talla de los hijos, independientemente de la etnia y vulnerabilidad social, representa un hecho alentador y sugiere que se debe estimular la formulación de intervenciones para los grupos m

Screening de trastornos de estrés postraumático en población afectada por el terremoto chileno de 2010

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Roberto Ariel Abeldaño

2014-11-01

Full Text Available Se analizó un screening de trastornos de estrés postraumático en habitantes chilenos, como consecuencia del terremoto de febrero de 2010; a partir de una Encuesta Post Terremoto con una muestra multietápica de 24.982 personas mayores de 18 años, a quienes se aplicó la Escala de Trauma de Davidson. La prevalencia de screening positivo para los trastornos de estrés postraumático fue del 11% en el país, pero a menor nivel de desagregación llegaron a observarse prevalencias del 30%. El modelo de regresión logística para la estimación de la variable trastornos de estrés postraumático identificó como factores de riesgo el hecho de pertenecer un hogar pobre, haber sufrido daños en la vivienda, haber tenido algún problema de salud en el último mes y ser mujer (p<0,05. También se encontró que el afrontamiento del sismo en familia resultó como un factor protector, en relación a afrontarlo con otros colectivos sociales (vecinos, la mayor cantidad de años de educación formal también fue identificada como un factor de protección (p<0,05. Se observaron claras desigualdades sociales en las personas que presentaron un screening positivo.

LA EXTERNALIZACIÓN LABORAL Y LA CESIÓN ILEGAL DE TRABAJADORES EN EL SISTEMA JURÍDICO CHILENO Labor outsourcing and illegal cession of workers at the chilean law system

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Irene Rojas Miño

2010-01-01

Full Text Available Este trabajo identifica a la cesión ilegal de trabajadores como manifestación ilícita de la externalización laboral. A la vez, analiza la configuración de la cesión ilegal de trabajadores en el ordenamiento jurídico chileno, sus concretos efectos jurídicos y, además, un particular problema que se ha planteado con la eficacia de la norma jurídica que establece este ilícito laboral.This work identifies the illegal cession of workers, as the illicit manifestation of the labor outsourcing. At the same time, it analyzes the illegal cession of workers configuration at the Chilean law system, its specifics legal effects and a particular problem derived of the efficiency of the law that establishes this labor illicit.

The caregiver burden in lupus: findings from UNVEIL, a national online lupus survey in the United States.

Science.gov (United States)

Al Sawah, S; Daly, R P; Foster, S A; Naegeli, A N; Benjamin, K; Doll, H; Bond, G; Moshkovich, O; Alarcón, G S

2017-01-01

Lupus imposes a substantial burden on patients; however, little is known about its impact on those caring for patients with the disease. In this study, we examined the impact 'caring for patients with lupus' has on caregivers from their own perspective. UNVEIL was a one-time online national cross-sectional survey developed in partnership with the Lupus Foundation of America and fielded targeting the US Lupus Foundation of America constituents in 2014. Eligible caregivers were adults who self-identified as unpaid caregivers of patients with lupus. Eligible caregivers had to complete a series of sociodemographic questions as well as a series of well established outcome measures, such as the Short Form 12v2 Health Survey, the Work Productivity and Activity Index, the Caregiver Burden Inventory, and the Perceived Benefits of Caregiving Scale. A total of 253 caregivers completed the survey. The majority of caregivers (90.1%) were aged 60 years or younger, more than half (54.2%) were men, and more than half (59.7%) identified themselves as either a spouse or a partner to the patient with lupus they were caring for. Overall health-related quality of life was close to the norm mean of the general US population. Caregivers who were employed missed an average of 12.8% of paid work time due to caregiving responsibilities and reported a 33.5% reduction in on-the-job effectiveness. Nearly half of the caregivers surveyed (49.4%) indicated that their caregiving responsibilities impacted their ability to socialize with friends, and almost all caregivers (97.6%) reported experiencing increased anxiety and stress in relation to their caregiving role. Caregiving for patients with lupus has a substantial impact on the work productivity and the social and emotional functioning of caregivers. Healthcare professionals and policymakers should continually assess the impact of healthcare decisions on the well-being of those caring for patients with lupus. © The Author(s) 2016.

Neuropsychiatric Systemic Lupus Erythematosus

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Popescu, Alexandra; Kao, Amy H

2011-01-01

Neuropsychiatric systemic lupus erythematosus (NPSLE) is the least understood, yet perhaps the most prevalent manifestation of lupus. The pathogenesis of NPSLE is multifactorial and involves various inflammatory cytokines, autoantibodies, and immune complexes resulting in vasculopathic, cytotoxic and autoantibody-mediated neuronal injury. The management of NPSLE is multimodal and has not been subjected to rigorous study. Different treatment regimens include nonsteroidal anti-inflammatory drugs, anticoagulation, and immunosuppressives such as cyclophosphamide, azathioprine, mycophenolate mofetil, and methotrexate. For refractory NPSLE, intravenous immunoglobulin (IVIG), plasmapheresis, and rituximab have been used. Adjunctive symptomatic treatment complements these therapies by targeting mood disorders, psychosis, cognitive impairment, seizures or headaches. Several new biological agents are being tested including Belimumab, a human monoclonal antibody that targets B lymphocyte stimulator. This review focuses on the pathophysiology, treatment, and new potential therapies for neuropsychiatric manifestations of systemic lupus erythematosus. PMID:22379459

Lupus eritematoso sistêmico associado a miastenia gravis: relato de caso Systemic lupus erythematosus and myasthenia gravis: case report

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MARCIO F. DE CARVALHO

1998-03-01

Full Text Available Os autores descrevem o caso de uma mulher branca de 24 anos de idade admitida com lupus eritematoso sistêmico (com 4 anos de evolução de doença e início recente de miastenia gravis. São discutidos os principais diagnósticos diferenciais para a fraqueza muscular e a fadiga apresentadas por esta paciente. Uma revisão de literatura abordando a associação de miastenia gravis e lupus eritematoso é feita, com ênfase às características clínicas desses pacientes e ao papel do timoma e timectomia no desenvolvimento de lupus eritematoso em pacientes previamente miastênicos.We report the case of a 24-year-old white woman admitted with a four year diagnosis of systemic lupus erythematosus and the recent onset of myasthenia gravis discussing the main differential diagnosis of weakness and fatigue in this patient. A review of literature approaching the association of myasthenia gravis and systemic lupus erythematosus is also done with emphasis on the clinical characteristics of these patients and the role of thymoma and thymectomy in the development of systemic lupus erythematosus in myasthenic patients.

Biomarkers for Lupus Nephritis: A Critical Appraisal

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Chi Chiu Mok

2010-01-01

Full Text Available Kidney disease is one of the most serious manifestations of systemic lupus erythematosus (SLE. Despite the improvement in the medical care of SLE in the past two decades, the prognosis of lupus nephritis remains unsatisfactory. Besides exploring more effective but less toxic treatment modalities that will further improve the remission rate, early detection and treatment of renal activity may spare patients from intensive immunosuppressive therapies and reduce renal damage. Conventional clinical parameters such as creatinine clearance, proteinuria, urine sediments, anti-dsDNA, and complement levels are not sensitive or specific enough for detecting ongoing disease activity in the lupus kidneys and early relapse of nephritis. Thus, novel biomarkers are necessary to enhance the diagnostic accuracy and sensitivity of lupus renal disease, prognostic stratification, monitoring of treatment response, and detection of early renal flares. This paper reviews promising biomarkers that have recently been evaluated in longitudinal studies of lupus nephritis.

Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens

Science.gov (United States)

Lech, Maciej; Kulkarni, Onkar P.; Pfeiffer, Stephanie; Savarese, Emina; Krug, Anne; Garlanda, Cecilia; Mantovani, Alberto; Anders, Hans-Joachim

2008-01-01

The Sigirr gene (also known as Tir8) encodes for an orphan receptor of the Toll-like receptor (TLR)/interleukin 1 receptor family that inhibits TLR-mediated pathogen recognition in dendritic cells. Here, we show that Sigirr also inhibits the activation of dendritic cells and B cells upon exposure to RNA and DNA lupus autoantigens. To evaluate the functional role of Sigirr in the pathogenesis of systemic lupus erythematosus (SLE), we generated Sigirr-deficient C57BL/6-lpr/lpr mice. These mice developed a progressive lymphoproliferative syndrome followed by severe autoimmune lung disease and lupus nephritis within 6 mo of age as compared with the minor abnormalities observed in C57BL/6-lpr/lpr mice. Lack of Sigirr was associated with enhanced activation of dendritic cells and increased expression of multiple proinflammatory and antiapoptotic mediators. In the absence of Sigirr, CD4 T cell numbers were increased and CD4+CD25+ T cell numbers were reduced. Furthermore, lack of Sigirr enhanced the activation and proliferation of B cells, including the production of autoantibodies against multiple nuclear lupus autoantigens. These data identify Sigirr as a novel SLE susceptibility gene in mice. PMID:18644972

Headache in Systemic Lupus Erythematosus

DEFF Research Database (Denmark)

Hanly, John G; Urowitz, Murray B; O'Keeffe, Aidan G

2013-01-01

To examine the frequency and characteristics of headaches and their association with global disease activity and health-related quality of life (HRQOL) in patients with systemic lupus erythematosus (SLE).......To examine the frequency and characteristics of headaches and their association with global disease activity and health-related quality of life (HRQOL) in patients with systemic lupus erythematosus (SLE)....

NIÑOS y adolescentes con necesidades educativas especiales

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S. Isabel Margarita López, Dra.

2015-01-01

Full Text Available Se viven tiempos de grandes y rápidos cambios socioeconómicos, culturales y tecnológicos. Las sociedades actuales promueven la equidad en un sentido amplio, afirmando el valor de la diversidad y la necesidad de la inclusión. Los conceptos de Necesidades Educativas Especiales (NEE y de inclusión cobran fuerza, con la reafirmación del derecho fundamental de todos los niños/as y jóvenes a acceder a la educación, reconociendo que cada uno de ellos “posee características, intereses, capacidades y necesidades de aprendizajes que le son propios”. En este artículo se revisan los conceptos actuales de discapacidad, NEE e inclusión, las principales condiciones que afectan a niños y adolescentes que tienen NEE y se discute en torno a las diferentes modalidades y herramientas pedagógicas actualmente disponibles en el sistema educativo chileno para cumplir esta tarea.

Predictores individuales y familiares de diferentes trayectorias de sintomatología depresiva en adolescentes chilenos

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Patricio Cumsille

2015-01-01

Full Text Available La sintomatología depresiva es prevalente durante la adolescencia, pero no todos los adolescentes experimentan el mismo nivel y evolución de esta sintomatología, lo que sugiere la necesidad de identificar diferencias en las trayectorias de los síntomas. Usando Growth Mixture Modeling analizamos diferentes trayectorias de síntomas depresivos en 1.072 adolescentes chilenos (12-15 años, 54% mujeres, NSE diverso. Primero, se seleccionó un modelo basal y luego se utilizó la irritabilidad del adolescente, la calidez, demanda y falta de respeto de la madre como predictores de la pertenencia a las clases. Se seleccionó un modelo con cuatro clases latentes de síntomas depresivos: alta persistente (12%, baja estable (56%, decreciente (15% y creciente (17%. La clase baja estable fue la más prevalente y se caracterizó por alto nivel de calidez maternal y bajo nivel de falta de respeto materna e irritabilidad del adolescente, en tanto que la clase alta persistente presentó características opuestas (baja calidez y alta demanda materna e irritabilidad del adolescente. Se observaron diferencias en la prevalencia de clases por sexo. Estos resultados resaltan la importancia de identificar diferentes trayectorias de síntomas depresivos y sus predictores. La asociación entre las dimensiones parentales y las trayectorias de síntomas depresivos persistentes provee evidencia de que los comportamientos parentales pueden servir, tanto como factores protectores como de riesgo.

Motivação para aprender: o autorrelato de professores brasileiros e chilenos Motivación para aprender: medida del auto-relato de profesores brasileños y chilenos Motivation to learn: measuring the self-report of Brazilian and Chilean teachers

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Sandra Maieski

2013-04-01

Full Text Available Foi objetivo deste estudo verificar a percepção de professores de duas realidades culturais diferentes: Brasil e Chile, quanto às qualidades do comportamento motivado ou desmotivado de seus alunos para aprender. Trata-se de um estudo do tipo descritivo com delineamento de levantamento e tratamento por meio da análise de conteúdo. Participaram 16 professores do ensino fundamental, sendo 7 brasileiros e 9 chilenos. Os dados foram mensurados, mediante de uma entrevista aberta com o professor e categorizados de acordo com os comportamentos motivado e desmotivado apresentados pelos alunos na visão de seus professores. Para tanto, geraram-se dados inerentes ao comportamento motivado e desmotivado apresentado pelos alunos na visão de seus professores. Os dados revelaram muita semelhança na forma como os professores das duas realidades culturais percebem as qualidades relacionadas ao comportamento motivado ou desmotivado de seus alunos. A discussão dos resultados levantados se dá em termos de algumas implicações educacionais.Fue el objetivo de este estudio verificar la percepción de profesores de dos realidades culturales distintas: Brasil y Chile, en cuanto a las cualidades del comportamiento motivado o desmotivado de sus alumnos para aprender. Se trata de un estudio de tipo descriptivo, con delineamiento de levantamiento y tratamiento por medio de análisis de contenido. Participaron 16 profesores de la enseñanza básica, siendo 7 brasileños y 9 chilenos. Los datos fueron medidos por medio de una entrevista abierta con el profesor y categorizados. Para eso, se generaron datos inherentes al comportamiento motivado y desmotivado presentado por los alumnos en la visión de sus profesores. Los datos revelaron mucha semejanza en la forma como los profesores de las dos realidades culturales perciben las cualidades relacionadas al comportamiento motivado o desmotivado de sus alumnos. La discusión de los resultados levantados se da en t

Atención Primaria de Salud: Factores de Desmotivación y Estabilidad Laboral de Médicos Generales

OpenAIRE

Ríos Heldt, Fabiola; Schonhaut Berman, Luisa

2009-01-01

Objetivo. Conocer las motivaciones laborales de los médicos chilenos con mayor permanencia en Atención Primaria de Salud (APS). Metodología. Estudio cuanti-culitativo descriptivo. Se reunió información biodemográfica y laboral de médicos chilenos que trabajaban en 10 de 15 establecimientos de APS de un Servicio de Salud urbano (Región Metropolitana). Siete médicos con mayor estabilidad laboral, es decir, permanencia superior al promedio, y 2 directivos fueron entrevistados en profundidad. Los...

Hair and Scalp Changes in Cutaneous and Systemic Lupus Erythematosus.

Science.gov (United States)

Udompanich, Siriorn; Chanprapaph, Kumutnart; Suchonwanit, Poonkiat

2018-06-09

Cutaneous and systemic lupus erythematosus (SLE) commonly involves the hair and scalp. Alopecia can result from direct activity of disease on the scalp or from the state of physical stress in the form of telogen effluvium. Discoid lupus erythematosus and lupus panniculitis/profundus are known to cause scarring alopecia, while accumulation of recent studies has shown that non-scarring alopecia in SLE may have different subtypes, comprising lupus erythematosus-specific and lupus erythematosus-nonspecific changes on histology. This review aims to summarize the clinical pattern, trichoscopic, histopathological, and direct immunofluorescence features of different types of alopecia in cutaneous and systemic lupus erythematosus, as well as exploring their relationship with SLE disease activity.

Lupus, discoid on a child's face (image)

Science.gov (United States)

The round or disk shaped (discoid) rash of lupus produces red, raised patches with scales. The pores ( ... The majority (approximately 90%) of individuals with discoid lupus have only skin involvement as compared to more ...

Cinema chileno e capitalismo neoliberal. Apontamentos para uma crítica da economia política da produção cinematográfica

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Roberto Trejo Ojeda

2016-11-01

Full Text Available Nos últimos vinte anos foram produzidos no Chile quase o dobro dos longas-metragens realizados durante todo o século XX. As razões econômicas, tecnológicas e políticas que permitiram o boom do cinema chileno serão analisadas aqui desde uma perspectiva crítica, questionando os fatores estruturantes do desenvolvimento cinematográfico funcionais ao modelo econômico neoliberal chileno. Argumento que tal cinema pode ser definido estética, ética, conceitual e teóricamente a partir do próprio regime de produção que o engendra. Como tal, pode ser descrito estéticamente como anódino, culturalmente conservador, éticamente individualista, ideológicamente de direita e discursivamente “progresista”.

Lupus panniculitis involving the breast

International Nuclear Information System (INIS)

Sabate, Josep M.; Gomez, Antonio; Torrubia, Sofia; Salinas, Teresa; Clotet, Montse; Lerma, Enrique

2006-01-01

Lupus panniculitis is an unusual immunological disease that characteristically affects the subcutaneous fat and occurs in 2% of patients with systemic lupus erythematosus. We report a case of lupus panniculitis involving the breast, which represents a very uncommon location. Mammographically, it presented as a suspicious irregular mass involving the subcutaneous fat pad with skin thickening. High echogenicity constituted the most relevant sonographic finding. To the best of our knowledge, the magnetic resonance (MR) features have not been previously described. High signal intensity was found on both T1- and T2-weighted precontrast MR images. A dynamic contrast-enhanced study revealed a suspicious focal mass with irregular margins and rim enhancement, with a type 3 time-signal intensity curve. Differential diagnosis with carcinoma and fat necrosis and the value of core biopsy are discussed. (orig.)

Actos asertivos y cortesía: las diferentes estrategias utilizadas por brasileños y chilenos en el contexto académico

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Adriana Marcelle de Andrade Freitas

2016-07-01

Full Text Available Con foco en la manifestación de la cortesía, en esta investigación buscamos describir y contrastar estrategias pragmáticas, en portugués y español, en comunidades de habla en São Paulo y Santiago de Chile. Nos proponemos indagar qué recursos los interlocutores, universitarios en encuentros orales con fines de estudio, utilizan en la actividad de imagen en actos asertivos. Para tanto, presentamos aquí una propuesta metodológica que pretende delinear el trasfondo de las construcciones discursivas. El corpus de este estudio se compone de veinticinco horas de videograbaciones y ochenta test de hábitos sociales (Hernández Flores, 2002; Contreras, 2004 y Bernal, 2007. En un análisis sincrónico, identificamos en el contexto brasileño, la tendencia del individuo a proyectar la imagen de cordialidad, cooperación y semejanza en la gestión de la autoimagen. Entre los interlocutores chilenos, la imagen de orden y la imagen de jerarquía fueron las que se evidenciaron. Destacamos contrastes, además de semejanzas, entre algunas estrategias pragmáticas, en relación con el fenómeno de la atenuación asertiva e intensificación, mecanismos de autorrepetición y alorrepetición. Los resultados, que encontraron eco en estudios de otras ciencias del comportamiento humano, en el análisis del corpus y en las respuestas de los informantes al test de hábitos sociales, pueden facilitar la proyección de experiencias específicas de un corpus a un estilo de cortesía que se extienda a otras situaciones de comunicación sin prescindir de la enorme diversidad del uso del lenguaje (Bravo, 2004a.

[Lupus erythematosus panniculitis presenting as palpebral edema and parotiditis].

Science.gov (United States)

Pérez-Pastor, G; Valcuende, F; Tomás, G; Moreno, M

2007-10-01

Lupus erythematosus panniculitis or lupus erythematosus profundus is characterized by inflammation of the deep dermis and subcutaneous tissue. It can occur in isolation or associated with chronic systemic or discoid lupus erythematosus. It usually consists of nodules and hardened subcutaneous plaques on the forehead, cheeks, proximal extremities, and buttocks. Periorbital and parotid involvement are rare and can lead to misdiagnosis. We present the case of a patient with lupus erythematosus panniculitis who presented with palpebral edema and involvement of the periocular fat and parotid gland.

Occurrence of systemic lupus erythematosus in a Danish community

DEFF Research Database (Denmark)

Laustrup, H; Voss, A; Green, A

2009-01-01

Objectives: To determine the prevalence and annual incidence of definite systemic lupus erythematosus (D-SLE) and incomplete SLE (I-SLE) in a community-based lupus cohort of predominantly Nordic ancestry in an 8-year prospective study from 1995 to 2003, and also to calculate the annual transition......-years at risk [95% confidence interval (CI) 1.44-7.55]. Conclusions: Denmark is a low-incidence lupus area but lupus prevalence is increasing slowly. I-SLE is a disease variant that may eventually convert into D-SLE....

Breast Cancer in Systemic Lupus Erythematosus

DEFF Research Database (Denmark)

Tessier Cloutier, B; Clarke, A E; Ramsey-Goldman, R

2013-01-01

Evidence points to a decreased breast cancer risk in systemic lupus erythematosus (SLE). We analyzed data from a large multisite SLE cohort, linked to cancer registries.......Evidence points to a decreased breast cancer risk in systemic lupus erythematosus (SLE). We analyzed data from a large multisite SLE cohort, linked to cancer registries....

Drug-induced cutaneous lupus erythematosus

DEFF Research Database (Denmark)

Laurinaviciene, Rasa; Holm Sandholdt, Linda; Bygum, Anette

2017-01-01

BACKGROUND: An increasing number of drugs have been linked to drug-induced subacute cutaneous lupus erythematosus (DI-SCLE). The recognition and management of DI-SCLE can be challenging, as the condition may be triggered by different classes of drugs after variable lengths of time. OBJECTIVES......: To determine the proportion of patients with cutaneous lupus erythematosus (CLE) whose drugs are an inducing or aggravating factor. MATERIALS & METHODS: We conducted a retrospective chart review of patients diagnosed with CLE at a dermatological department over a 21-year period. We registered clinical......, serological, and histological data with a focus on drug intake. RESULTS: Of 775 consecutive patients with a diagnosis of lupus erythematosus (LE) or suspected LE, a diagnosis of CLE could be confirmed in 448 patients. A total of 130 patients had a drug intake that could suggest DI-SCLE. In 88 cases, a drug...

LARGE-SCALE CO MAPS OF THE LUPUS MOLECULAR CLOUD COMPLEX

International Nuclear Information System (INIS)

Tothill, N. F. H.; Loehr, A.; Stark, A. A.; Lane, A. P.; Harnett, J. I.; Bourke, T. L.; Myers, P. C.; Parshley, S. C.; Wright, G. A.; Walker, C. K.

2009-01-01

Fully sampled degree-scale maps of the 13 CO 2-1 and CO 4-3 transitions toward three members of the Lupus Molecular Cloud Complex-Lupus I, III, and IV-trace the column density and temperature of the molecular gas. Comparison with IR extinction maps from the c2d project requires most of the gas to have a temperature of 8-10 K. Estimates of the cloud mass from 13 CO emission are roughly consistent with most previous estimates, while the line widths are higher, around 2 km s -1 . CO 4-3 emission is found throughout Lupus I, indicating widespread dense gas, and toward Lupus III and IV. Enhanced line widths at the NW end and along the edge of the B 228 ridge in Lupus I, and a coherent velocity gradient across the ridge, are consistent with interaction between the molecular cloud and an expanding H I shell from the Upper-Scorpius subgroup of the Sco-Cen OB Association. Lupus III is dominated by the effects of two HAe/Be stars, and shows no sign of external influence. Slightly warmer gas around the core of Lupus IV and a low line width suggest heating by the Upper-Centaurus-Lupus subgroup of Sco-Cen, without the effects of an H I shell.

Novel Therapeutic Target for the Treatment of Lupus

Science.gov (United States)

2014-09-01

AWARD NUMBER: W81XWH-12-1-0205 TITLE: Novel Therapeutic Target for the Treatment of Lupus PRINCIPAL INVESTIGATOR: Lisa Laury-Kleintop...SUBTITLE 5a. CONTRACT NUMBER Novel Therapeutic Target for the Treatment of Lupus 5b. GRANT NUMBER W81XWH-12-1-0205 5c. PROGRAM ELEMENT NUMBER 6...Systemic lupus erythematosus, autoantibodies. 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 7 19a. NAME OF

Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort

DEFF Research Database (Denmark)

Urowitz, M B; Gladman, D D; Anderson, N M

2016-01-01

OBJECTIVE: To describe the frequency of myocardial infarction (MI) prior to the diagnosis of systemic lupus erythematosus (SLE) and within the first 2 years of follow-up. METHODS: The systemic lupus international collaborating clinics (SLICC) atherosclerosis inception cohort enters patients within......% CI 2.38 to 23.57) remained significant risk factors. CONCLUSIONS: In some patients with lupus, MI may develop even before the diagnosis of SLE or shortly thereafter, suggesting that there may be a link between autoimmune inflammation and atherosclerosis....

1814 en Chile: de la desobediencia a Lima a la ruptura con España

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Ossa Santa Cruz, Juan Luis

2016-06-01

Full Text Available This article analyzes how the Chilean revolutionaries moved from the disobedience to Lima to the break with Spain in 1814. First, it studies the origins of the civil war that hit Chile since 1813. Then it studies the political factionalism within the revolutionary side and the importance of the Treaty of Lircay. Finally, it presents an account of the Americanist approach adopted by the Chilean rebels after signing a political and military alliance with José de San Martín.Este artículo interpreta el paso de la desobediencia a Lima a la ruptura definitiva con España durante el año 1814. Primero estudia los orígenes de la guerra civil en Chile comenzada en 1813. Luego presenta las causas del faccionalismo en el bando revolucionario y enfatiza la importancia del Tratado de Lircay. Finalmente, analiza la causa americanista seguida por los rebeldes chilenos después de firmar una alianza político-militar con José de San Martín.

Elevated sacroilac joint uptake ratios in systemic lupus erythematosus

International Nuclear Information System (INIS)

De Smet, A.A.; Mahmood, T.; Robinson, R.G.; Lindsley, H.B.

1984-01-01

Sacroiliac joint radiographs and radionuclide sacroiliac joint uptake ratios were obtained on 14 patients with active systemic lupus erythematosus. Elevated joint ratios were found unilaterally in two patients and bilaterally in seven patients when their lupus was active. In patients whose disease became quiescent, the uptake ratios returned to normal. Two patients had persistently elevated ratios with continued clinical and laboratory evidence of active lupus. Mild sacroiliac joint sclerosis and erosions were detected on pelvic radiographs in these same two patients. Elevated quantitative sacroiliac joint uptake ratios may occur as a manifestation of active systemic lupus erythematosus

Lupus nephritis management guidelines compared.

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Wilhelmus, Suzanne; Bajema, Ingeborg M; Bertsias, George K; Boumpas, Dimitrios T; Gordon, Caroline; Lightstone, Liz; Tesar, Vladimir; Jayne, David R

2016-06-01

In the past years, many (randomized) trials have been performed comparing the treatment strategies for lupus nephritis. In 2012, these data were incorporated in six different guidelines for treating lupus nephritis. These guidelines are European, American and internationally based, with one separate guideline for children. They offer information on different aspects of the management of lupus nephritis including induction and maintenance treatment of the different histological classes, adjunctive treatment, monitoring of the patient, definitions of response and relapse, indications for (repeat) renal biopsy, and additional challenges such as the presence of vascular complications, the pregnant SLE patient, treatment in children and adolescents and considerations about end-stage renal disease and transplantation. In this review, we summarize the guidelines, determine the common ground between them, highlight the differences and discuss recent literature. © The Author 2015. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

Dutch guidelines for diagnosis and therapy of proliferative lupus nephritis

NARCIS (Netherlands)

van Tellingen, A.; Voskuyl, A. E.; Vervloet, M. G.; Bijl, M.; de Sevaux, R. G. L.; Berger, S. P.; Derksen, R. H. W. M.; Berden, J. H. M.

Proliferative lupus nephritis is a strong predictor of morbidity and mortality in patients with systemic lupus erythematosus. Despite improvements in the management of lupus nephritis, a significant number of the patients do not respond to immunosuppressive therapy and progress to end-stage renal

The existential experience of everyday life with systemic lupus erythematosus.

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Larsen, Janni Lisander; Hall, Elisabeth O C; Jacobsen, Søren; Birkelund, Regner

2018-05-01

To explore from the perspective of women the nature of basic existential conditions while living with systemic lupus erythematosus. Systemic lupus erythematosus has an unpredictable disease course and is documented to cause an existential rearrangement of life. The significance of changes in existential conditions and related experiences are unclear in the context of nursing and women with systemic lupus erythematosus. A qualitative design guided by Van Manen's hermeneutic-phenomenological methodology. Individual in-depth interviews with 15 women diagnosed with systemic lupus erythematosus and of various ages, disease durations and severities were undertaken from September 2013 - October 2015. Data were analysed following van Manen's phenomenological approach and using drawing as an interpretive tool. The main existential experience was interpreted as a person "moving with the waves of systemic lupus erythematosus" constituted by the themes "oscillating between presence and absence of systemic lupus erythematosus," "recognizing space and bodily possibilities and limitations" and "being enriched through relationships and activities." When systemic lupus erythematosus was flaring, well-being was threatened and a laborious time to escape the feeling of a setback-in-life persisted long after the disease was medically under control. Daily life with systemic lupus erythematosus is conditioned by a prominent need to be in existential motion, related to the absence and presence of systemic lupus erythematosus. The experience of a setback-in-life by illness might challenge well-being and indicates that periods of disease flares or disturbing symptoms are critical time points to provide support. © 2018 John Wiley & Sons Ltd.

[Cardiac tamponade disclosing systemic lupus erythematosus].

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Nour-Eddine, M; Bennis, A; Soulami, S; Chraibi, N

1996-02-01

Cardiac tamponade secondary to systemic lupus erythematosus is rare and has a very serious prognosis. The authors report a case of cardiac tamponade confirmed by echocardiography, which constituted the presenting sign of systemic lupus erythematosus in a 20-year-old patient, who required emergency pericardial aspiration. The diagnosis of systemic lupus erythematosus was established on the basis of the combination of pericardial involvement, non-erosive arthritis, leukopenia with lymphopenia, presence of LE cells and anti-native DNA antibodies and positive antinuclear antibody titre of 1/2560. The clinical course was favourable in response to 3 months of corticosteroid treatment. The possibility of SLE should be considered in any case of cardiac tamponade in a young patient in which the aetiology is not explained.

Toll-like receptor activation in the pathogenesis of lupus nephritis.

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Lorenz, Georg; Lech, Maciej; Anders, Hans-Joachim

2017-12-01

The pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis is complex but no longer enigmatic. Much progress has been made to on the polygenetic origin of lupus in identifying gene variants that permit the loss of tolerance against nuclear autoantigens. Along the same line in about 50% of lupus patients additional genetic weaknesses promote immune complex glomerulonephritis and filtration barrier dysfunction. Here we briefly summarize the pathogenesis of SLE with a focus on loss of tolerance and the role of toll-like receptors in the "pseudo"-antiviral immunity concept of systemic lupus. In addition, we discuss the local role of Toll-like receptors in intrarenal inflammation and kidney remodeling. Copyright © 2016 Elsevier Inc. All rights reserved.

Economic evaluation of lupus nephritis in the Systemic Lupus International Collaborating Clinics inception cohort using a multistate model approach

DEFF Research Database (Denmark)

Barber, Megan R W; Hanly, John G; Su, Li

2018-01-01

OBJECTIVE: Little is known about the long-term costs of lupus nephritis (LN). These were compared between patients with and without LN based on multistate modelling. METHODS: Patients from 32 centres in 11 countries were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC...

Value of HLA-DR genotype in systemic lupus erythematosus and lupus nephritis: a meta-analysis.

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Niu, Zhili; Zhang, Pingan; Tong, Yongqing

2015-01-01

Human leukocyte antigen (HLA)-DRB1 allele polymorphisms have been reported to be associated with systemic lupus erythematosus (SLE) susceptibility, but the results of these previous studies have been inconsistent. The purpose of the present study was to systematically summarize and explore whether specific HLA-DRB1 alleles confer susceptibility or resistance to SLE and lupus nephritis. This review was guided by the preferred reporting items for systematic reviews and meta-analyses (PRISMA) approach. A comprehensive search was made for articles from PubMed, Medline, Elsevier Science, Springer Link and Cochrane Library database. A total of 25 case-control studies on the relationship between gene polymorphism of HLA-DRB l and SLE were performed and data were analyzed and processed using Review Manager 5.2 and Stata 11.0. At the allelic level, HLA-DR4, DR11 and DR14 were identified as protective factors for SLE (0.79 [0.69,0.91], P  0.05). DR4 and 11 (OR, 0.55 [0.39, 0.79], P  0.05; 0.90 [0.64, 1.27], P > 0.05; 0.61 [0.36, 1.03], P > 0.05, respectively) were not statistically significant between the lupus nephritis and control groups. The HLA-DR4, DR11, DR14 alleles might be protective factors for SLE and HLA-DR3, DR9, DR15 were potent risk factors. In addition, HLA-DR4 and DR11 alleles might be protective factors for lupus nephritis and DR3 and DR15 suggest a risk role. These results proved that HLA-DR3, DR15, DR4 and DR11 might be identified as predictors for lupus nephritis and SLE. © 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

Pancreatitis and systemic lupus erythematosus Pancreatitis y lupus eritematoso sistémico

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J. Lariño Noia

2009-08-01

Full Text Available Gastrointestinal symptoms in patients with SLE are common, specifically abdominal pain. However, the rate of pancreatic diseases is much lower and does not reach 5% according to published series in Europe and the USA. This association between SLE and pancreatic disease is basically at the expense of episodes of acute pancreatitis. An association with chronic pancreatitis is much more uncommon, and only four articles have been published showing this relationship. Three cases of SLE-associated pancreatitis are described, and disease onset, etiological factors, and clinical progression are analyzed. A review of the literature and a brief discussion about pathophysiological mechanisms and the role of corticosteroids are also included.Los síntomas gastrointestinales en los pacientes con lupus eritematoso sistémico (LES son comunes, específicamente el dolor abdominal. Sin embargo la tasa de enfermedades pancreáticas es mucho menor, una tasa que no alcanza ni al 5% según las series publicadas en Europa y EE. UU. Esta asociación entre enfermedades pancreáticas y LES es fundamentalmente a expensas de episodios de pancreatitis aguda. La asociación con pancreatitis crónica es muchísimo más infrecuente, teniendo en cuenta que tan sólo cuatro artículos han sido publicados reflejando esta asociación. Describimos tres casos de asociación entre pancreatitis y LES, analizando el debut de la enfermedad, los factores etiológicos y también la evolución clínica. Hemos realizado, además, una breve discusión de la fisiopatología y del papel de corticosteroides, así como una revisión de la literatura.

A Cutaneous Lupus Erythematosus-Like Eruption Induced by Hydroxyurea.

Science.gov (United States)

Yanes, Daniel A; Mosser-Goldfarb, Joy L

2017-01-01

Hydroxyurea is a medication with many well-described cutaneous side effects, notably the dermatomyositis-like eruption known as hydroxyurea dermopathy. Although systemic lupus erythematosus has been reported with hydroxyurea use, cutaneous lupus has not. We report a novel case of chronic cutaneous lupus induced by hydroxyurea and propose that this is a side effect that is distinct from hydroxyurea dermopathy. © 2016 Wiley Periodicals, Inc.

Lupus and Depression: Know the Signs and How to Get Help

Science.gov (United States)

... Donate Share on Twitter Facebook Pinterest Email Print Lupus and depression: Know the signs and how to ... free of lupus. Facts about clinical depression and lupus Between 15 and 60 percent of people with ...

Lupus: When the Body Attacks Itself | NIH MedlinePlus the Magazine

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... of this page please turn JavaScript on. Feature: Lupus Lupus: When the Body Attacks Itself Past Issues / Spring 2014 Table of Contents fast facts 1 Lupus occurs when the body's immune system attacks the ...

Mood Disorders in Systemic Lupus Erythematosus

DEFF Research Database (Denmark)

Hanly, John G; Su, Li; Urowitz, Murray B

2015-01-01

OBJECTIVE: To examine the frequency, characteristics, and outcome of mood disorders, as well as clinical and autoantibody associations, in a multiethnic/racial, prospective inception cohort of patients with systemic lupus erythematosus (SLE). METHODS: Patients were assessed annually for mood...... disorders (4 types, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) and 18 other neuropsychiatric events. Global disease activity scores (SLE Disease Activity Index 2000 [SLEDAI-2K]), damage scores (Systemic Lupus International Collaborating Clinics/American College...... was associated with Asian race/ethnicity (P = 0.01) and treatment with immunosuppressive drugs (P = 0.003). Mood disorders were associated with lower mental health and mental component summary scores but not with the SLEDAI-2K, SDI, or lupus autoantibodies. Among the 232 patients with depression, 168 (72...

Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis.

Science.gov (United States)

Mistry, Pragnesh; Kaplan, Mariana J

2017-12-01

Nephritis is one of the most severe complications of systemic lupus erythematosus (SLE). One key characteristic of lupus nephritis (LN) is the deposition of immune complexes containing nucleic acids and/or proteins binding to nucleic acids and autoantibodies recognizing these molecules. A variety of cell death processes are implicated in the generation and externalization of modified nuclear autoantigens and in the development of LN. Among these processes, apoptosis, primary and secondary necrosis, NETosis, necroptosis, pyroptosis, and autophagy have been proposed to play roles in tissue damage and immune dysregulation. Cell death occurs in healthy individuals during conditions of homeostasis yet autoimmunity does not develop, at least in part, because of rapid clearance of dying cells. In SLE, accelerated cell death combined with a clearance deficiency may lead to the accumulation and externalization of nuclear autoantigens and to autoantibody production. In addition, specific types of cell death may modify autoantigens and alter their immunogenicity. These modified molecules may then become novel targets of the immune system and promote autoimmune responses in predisposed hosts. In this review, we examine various cell death pathways and discuss how enhanced cell death, impaired clearance, and post-translational modifications of proteins could contribute to the development of lupus nephritis. Published by Elsevier Inc.

Correlation between the Modified Systemic Lupus Erythematosus Disease Activity Index 2000 and the European Consensus Lupus Activity Measurement in juvenile systemic lupus erythematosus.

Science.gov (United States)

Sato, J O; Corrente, J E; Saad-Magalhães, C

2016-11-01

Objective The objective of this study was to assess Modified Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and European Consensus Lupus Activity Measurement (ECLAM) disease activity correlation in addition to their respective correlation to Pediatric Systemic Lupus International Collaborative Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (Ped-SDI), in juvenile systemic lupus erythematosus (JSLE). Methods The activity indices were scored retrospectively and summarized by adjusted means during follow-up. The Ped-SDI was scored during the last visit for those with more than six months follow-up. Pearson correlation between the Modified SLEDAI-2K and ECLAM, as well as Spearman correlations between the Modified SLEDAI-2K, ECLAM, and Ped-SDI were calculated. The receiver operating characteristic (ROC) curve was calculated for both activity indices discriminating damage measured by Ped-SDI. Results Thirty-seven patients with mean age at diagnosis 11 ± 2.9 years and mean follow-up time 3.2 ± 2.4 years were studied. The Modified SLEDAI-2K and ECLAM adjusted means were highly correlated ( r = 0.78, p  0.7, p < 0.001), but Modified SLEDAI-2K and ECLAM correlation with Ped-SDI was only moderate. ROC analysis discriminant performance for both activity indices resulted in area under curve (AUC) of 0.74 and 0.73 for Modified SLEDAI-2K and ECLAM, respectively. Conclusion The high correlation found between the Modified SLEDAI-2K and ECLAM adjusted means indicated that both tools can be equally useful for longitudinal estimates of JSLE activity.

Más allá del “modelo” chileno: una aproximación multi-sectorial a las relaciones Estado-mercado

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Antoine Maillet

2015-09-01

Full Text Available ResumenChile ha sido muchas veces caracterizado como un “modelo” desde los años 1990. Sin embargo, esta clasificación opaca la diversidad existente en las relaciones Estado-mercado. En cambio, una aproximación mediante la comparación multisectorial permite dar cuenta de la heterogeneidad de las políticas públicas en relación a los mercados, y no confundirlas bajo un supuesto “modelo” uniforme. La demonstración se fundamenta en el análisis de las trayectorias sectoriales en materias de energía eléctrica, transporte público en Santiago y pensiones desde las reformas de los Chicago Boys durante la dictadura de Pinochet hasta hoy. Basado en análisis de prensa, entrevistas con actores claves, y una extensiva revisión de bibliografía especializada, se evidencia cómo las políticas, a partir de un mismo punto de origen al final de la dictadura, tomaron caminos distintos durante los gobiernos democráticos. El caso chileno aparece entonces más fragmentado que lo generalmente considerado. Más allá del caso, esta diversidad señala la necesidad de una mayor atención a los procesos de diferenciación y autonomización de las políticas públicas sectoriales.

Asertividad: Diferencias de sexo en estudiantes universitarios chilenos medidas a través del Inventario de Gambrill y Richey

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Jorge Maluenda Albornoz

2017-01-01

Full Text Available La presente investigación explora diferencias de sexo en asertividad medidas a través del Inventario de Asertividad de Gambrill y Richey variable considerada signiicativa para la formación transversal de profesionales. El objetivo es identiicar diferencias de sexo en relación a asertividad en un grupo de estudiantes universitarios chilenos. Se realiza un muestreo por conveniencia, y a partir de ello, un estudio descriptivo de corte transversal. El análisis estadístico se desarrolla a partir de la prueba t de Student y U de Mann y Whitney. El análisis por dimensión muestra diferencias de sexo en tres dimensiones para la escala Grado de Incomodidad: “Manifestar Oposición”, “Rechazar Solicitudes” e “Involucrarse en Situaciones Agradables” (p<0.005 . Por su parte, la escala Probabilidad de Respuesta ofrece diferencias de sexo signiicativas para cuatro dimensiones: “Manifestar Oposición”, “Exponerse a Situaciones Desconocidas” y “Manejar Situa- ciones Incómodas” (p<0.005, con puntajes mayores para las mujeres exceptuando en “Asumir Limitaciones Personales” donde hombres obtienen mayor puntaje. Se concluyen diferencias de sexo signiicativas en relación a asertividad para este grupo de estudiantes donde el rol de género ofrece una explicación para dichas diferencias.

Evaluating fatigue in lupus-prone mice: preliminary assessments.

Science.gov (United States)

Meeks, Allison; Larson, Susan J

2012-01-01

Fatigue is a debilitating condition suffered by many as the result of chronic disease, yet relatively little is known about its biological basis or how to effectively manage its effects. This study sought to evaluate chronic fatigue by using lupus-prone mice and testing them at three different time periods. Lupus-prone mice were chosen because fatigue affects over half of patients with Systemic Lupus Erythematosus. Eleven MLR⁺/(+) (genetic controls) and twelve MLR/MpJ-Fas/J (MRL/lpr; lupus-prone) mice were tested three times: once at 12, 16 and 20 weeks of age. All mice were subjected to a variety of behavioral tests including: forced swim, post-swim grooming, running wheel, and sucrose consumption; five of the MLR⁺/(+) and five of the MLR/lpr mice were also tested on a fixed ratio-25 operant conditioning task. MRL/lpr mice showed more peripheral symptoms of lupus than controls, particularly lymphadenopathy and proteinuria. Lupus mice spent more time floating during the forced swim test and traveled less distance in the running wheel at each testing period. There were no differences between groups in post-swim grooming or in number of reinforcers earned in the operant conditioning task indicating the behavioral changes were not likely due simply to muscle weakness or motivation. Correlations between performance in the running wheel, forced swim test and sucrose consumption were conducted and distance traveled in the running wheel was consistently negatively correlated with time spent floating. Based on these data, we conclude that the lupus-prone mice were experiencing chronic fatigue and that running wheel activity and floating during a forced swim test can be used to evaluate fatigue, although these data cannot rule out the possibility that both fatigue and a depressive-like state were mediating these effects. Copyright © 2011 Elsevier Inc. All rights reserved.

Proton pump inhibitor-induced subacute cutaneous lupus erythematosus

DEFF Research Database (Denmark)

Sandholdt, L H; Laurinaviciene, R; Bygum, Anette

2014-01-01

Drug-induced subacute cutaneous lupus erythematosus (SCLE) has been known in the literature since 1985 and is increasingly recognized.......Drug-induced subacute cutaneous lupus erythematosus (SCLE) has been known in the literature since 1985 and is increasingly recognized....

Radiological changes in systemic lupus erythematosis

Energy Technology Data Exchange (ETDEWEB)

Fritsch, R; Freyschmidt, J; Suedhof-Mueller, G; Menninger, H

1981-05-01

In a study of 50 patients with systemic lupus erythematosis, radiologically demonstrable lung changes and pleural effusions were found in 50%. Changes in the peripheral skeleton, such as osteoporosis, erosions or mutilations, were seen in only two patients. Our radiological analysis has shown that systemic lupus erythematosis does not produce changes in the joints, but is responsible for abnormalities in the lungs, as well as for pericardial and pleural effusions.

Algunas consideraciones respecto del fallo del tribunal constitucional chileno relativo a la distribución de la “píldora del día después”

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Juan Pablo Beca Frei

2009-06-01

Full Text Available En este artículo damos los fundamentos jurídicos de por qué resulta plenamente legítimo que el Tribunal Constitucional chileno se pronuncie sobre algunos aspectos de las Normas Chilenas sobre Fertilidad, en lo que concierne a la entrega de anticonceptivos de emergencia. En este fallo, el Tribunal Constitucional determinó que las normas contenidas en el Decreto Supremo Nº 48, de 26 de enero de 2007, del Ministerio de Salud son –desde el punto de vista jurídico– incompatibles con nuestras normas constitucionales. El segundo aspecto que analizamos desde el punto de vista jurídico es a quién corresponde el peso de la prueba. A nuestro parecer, lo que se prueba en cualquier juicio son hechos positivos, no hechos negativos, y quien debe probar es quien alega la ocurrencia de estos hechos. En consecuencia, consideramos que el Tribunal Constitucional debió haber exigido que los recurrentes probaran que el levonorgestrel impide el implante o anidación de un óvulo fecundado y no exigir al recurrido probar un hecho negativo, cual es que el mencionado producto no impide esta anidación. Reflexionamos además sobre ciertas imprecisiones del fallo, como aquellas relacionadas con el comienzo de la vida humana y la constitucionalidad de la consejería a menores.

Massive intracranial calcifications in a patient with systemic lupus erythematosus; Calcificacoes intracranianas macicas em um paciente com lupus eritematoso sistemico

Energy Technology Data Exchange (ETDEWEB)

Gasparetto, Emerson L.; Carvalho Neto, Arnolfo de [Parana Univ., Curitiba, PR (Brazil). Dept. de Clinica Medica. Servico de Radiologia Medica]. E-mail: gasparetto@hotmail.com; Ono, Sergio E. [Parana Univ., Curitiba, PR (Brazil). Faculdade de Medicina

2004-12-01

Central nervous system involvement is frequently reported in patients with systemic lupus erythematosus. Computed tomography and magnetic resonance imaging studies usually show brain atrophy, cerebral infarction and/or intracranial bleeding. Extensive intracranial calcification in patients with systemic lupus erythematosus is rare. We report a case of a patient with systemic lupus erythematosus who presented with seizures and massive basal ganglia calcification and mild calcifications in the frontal lobes, seen on the brain computed tomography scan. Magnetic resonance imaging showed hyperintensity on FLAIR images and hypointense signals on T2{sup *} gradient echo images in the basal ganglia. (author)

The Pathology of T Cells in Systemic Lupus Erythematosus

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Anselm Mak

2014-01-01

Full Text Available Systemic lupus erythematosus (SLE is characterized by the production of a wide array of autoantibodies. Thus, the condition was traditionally classified as a “B-cell disease”. Compelling evidence has however shown that without the assistance of the helper T lymphocytes, it is indeed difficult for the “helpless” B cells to become functional enough to trigger SLE-related inflammation. T cells have been recognized to be crucial in the pathogenicity of SLE through their capabilities to communicate with and offer enormous help to B cells for driving autoantibody production. Recently, a number of phenotypic and functional alterations which increase the propensity to trigger lupus-related inflammation have been identified in lupus T cells. Here, potential mechanisms involving alterations in T-cell receptor expressions, postreceptor downstream signalling, epigenetics, and oxidative stress which favour activation of lupus T cells will be discussed. Additionally, how regulatory CD4+, CD8+, and γδ T cells tune down lupus-related inflammation will be highlighted. Lastly, while currently available outcomes of clinical trials evaluating therapeutic agents which manipulate the T cells such as calcineurin inhibitors indicate that they are at least as efficacious and safe as conventional immunosuppressants in treating lupus glomerulonephritis, larger clinical trials are undoubtedly required to validate these as-yet favourable findings.

Lupus panniculitis

International Nuclear Information System (INIS)

Mondello, Eduardo; Vega, Alejandro de la; Eyheremendy, EduardoP.

2002-01-01

Lupus panniculitis (LP) is a benign entity. To our knowledge LP has not been reported in the radiology literature. Our objective is to describe imaging findings as previous articles have not focused on this aspect. Computed Tomography and MR imaging demonstrate lipoatrophy and isolated areas with inflammatory activity in the subcutaneous tissue. (author)

Retinal nerve fiber layer thickness and neuropsychiatric manifestations in systemic lupus erythematosus.

Science.gov (United States)

Shulman, S; Shorer, R; Wollman, J; Dotan, G; Paran, D

2017-11-01

Background Cognitive impairment is frequent in systemic lupus erythematosus. Atrophy of the corpus callosum and hippocampus have been reported in patients with systemic lupus erythematosus, and diffusion tensor imaging studies have shown impaired white matter integrity, suggesting that white matter damage in systemic lupus erythematosus may underlie the cognitive impairment as well as other neuropsychiatric systemic lupus erythematosus manifestations. Retinal nerve fiber layer thickness, as assessed by optical coherence tomography, has been suggested as a biomarker for white matter damage in neurologic disorders such as multiple sclerosis, Alzheimer's disease and Parkinson's disease. Retinal nerve fiber layer thinning may occur early, even in patients with mild clinical symptoms. Aim The objective of this study was to assess the association of retinal nerve fiber layer thickness, as a biomarker of white matter damage in systemic lupus erythematosus patients, with neuropsychiatric systemic lupus erythematosus manifestations, including cognitive impairment. Methods Twenty-one consecutive patients with systemic lupus erythematosus underwent neuropsychological testing using a validated computerized battery of tests as well as the Rey-Auditory verbal learning test. All 21 patients, as well as 11 healthy, age matched controls, underwent optical coherence tomography testing to assess retinal nerve fiber layer thickness. Correlations between retinal nerve fiber layer thickness and results in eight cognitive domains assessed by the computerized battery of tests as well as the Rey-Auditory verbal learning test were assessed in patients with systemic lupus erythematosus, with and without neuropsychiatric systemic lupus erythematosus, and compared to retinal nerve fiber layer thickness in healthy controls. Results No statistically significant correlation was found between retinal nerve fiber layer thickness in patients with systemic lupus erythematosus as compared to healthy

Environmental Factors, Toxicants and Systemic Lupus Erythematosus

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Anselm Mak

2014-09-01

Full Text Available Systemic lupus erythematosus (SLE is an immune-complex-mediated multi-systemic autoimmune condition of multifactorial etiology, which mainly affects young women. It is currently believed that the onset of SLE and lupus flares are triggered by various environmental factors in genetically susceptible individuals. Various environmental agents and toxicants, such as cigarette smoke, alcohol, occupationally- and non-occupationally-related chemicals, ultraviolet light, infections, sex hormones and certain medications and vaccines, have been implicated to induce SLE onset or flares in a number case series, case-control and population-based cohort studies and very few randomized controlled trials. Here, we will describe some of these recognized environmental lupus triggering and perpetuating factors and explain how these factors potentially bias the immune system towards autoimmunity through their interactions with genetic and epigenetic alterations. Further in-depth exploration of how potentially important environmental factors mechanistically interact with the immune system and the genome, which trigger the onset of SLE and lupus flares, will certainly be one of the plausible steps to prevent the onset and to decelerate the progress of the disease.

Validity of LupusQoL-China for the assessment of health related quality of life in Chinese patients with systemic lupus erythematosus.

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Su-li Wang

Full Text Available OBJECTIVES: To adapt and assess the validity and reliability of LupusQoL for use in Chinese patients with systemic lupus erythematosus (SLE. METHODS: Debriefing interviews of subjects with SLE guided the language modifications of the tool. The process of adaptation proceeded according to the guideline and pre-testing results of LupusQoL-China. 220 SLE patients completed LupusQoL-China and a generic preference-based measurement of health EuroQoL scale (EQ-5D, and 20 patients repeated them after 2 weeks. Internal consistency (ICR and test-retest (TRT reliability, convergent and discriminant validity were examined. Factor analysis and Rasch analysis were performed. RESULTS: The mean (SD age of the 208 subjects with SLE was 33.93 (± 9.19 years. ICR and TRT of the eight domains ranged from 0.811 to 0.965 and 0.836 to 0.974, respectively. The LupusQoL-China domains demonstrated substantial evidence of construct validity when compared with equivalent domains on the EQ-5D (physical health and usual activities r = -0.63, pain and pain/discomfort r = -0.778, emotional health and anxiety/depression r = -0.761, planning and usual activities r = -0.560. Most LupusQoL-China domains could discriminate patients with varied disease activities and end-organ damage (according to SELENA-SLEDAI and SLICC-DI. The principal component analysis revealed six factors, and confirmatory factor analysis result of which is similar to eight factors model. CONCLUSIONS: These results provide evidence that the LupusQoL-China is valid as a disease-specific HRQoL assessment tool for Chinese patients with SLE.

Hypoparathyroidism associated with systemic lupus erythematosus.

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Gazarian, M; Laxer, R M; Kooh, S W; Silverman, E D

1995-11-01

We describe a 15-year-old girl with systemic lupus erythematosus (SLE) who presented with hypocalcemia and a generalized seizure in the setting of an intercurrent illness and active central nervous system lupus. She was subsequently found to have idiopathic hypoparathyroidism. The association of SLE with hypoparathyroidism is extremely rare and this case represents the first pediatric report of this rare association. We suggest there may be a common underlying pathophysiological process linking these diseases.

Radiological changes in systemic lupus erythematosis

International Nuclear Information System (INIS)

Fritsch, R.; Freyschmidt, J.; Suedhof-Mueller, G.; Menninger, H.; Medizinische Hochschule Hannover

1981-01-01

In a study of 50 patients with systemic lupus erythematosis, radiologically demonstrable lung changes and pleural effusions were found in 50%. Changes in the peripheral skeleton, such as osteoporosis, erosions or mutilations, were seen in only two patients. Our radiological analysis has shown that systemic lupus erythematosis does not produce changes in the joints, but is responsible for abnormalities in the lungs, as well as for pericardial and pleural effusions. (orig.) [de

Lupus nephritis

African Journals Online (AJOL)

1991-03-02

Mar 2, 1991 ... will benefit from immunosuppressive therapy. Our study found hypertension, which persisted at the most recent follow-up, to be associated with a poor outcome, as was poor renal function both at biopsy and follow-up. Leaker er al. I found that survival in lupus nephritis is unaffected by age, sex, nephrotic ...

Prognosis and predictors of convulsion among pediatric lupus nephritis patients

International Nuclear Information System (INIS)

Beiraghdar, Fatemeh; Einollahi, Behzad; Taheri, Saeed; Panahi, Yunes; Maddani, Abbas; Esfahani, Taher; Sharifi-Bonab, Mir Mohsen

2009-01-01

In this study, we aimed to analyze features and outcome of convulsion in pediatric lupus nephritis patients. We retrospectively reviewed data of 14 Iranian children with lupus nephritis who developed seizures and compared them with a group of the same number of well matched pediatric lupus nephritis patients. Higher serum creatinine levels and higher frequencies of anemia and lymphopenia were observed in the convulsion group. Multivariable logistic regression analysis revealed that the only risk factor for development of convulsion in pediatric lupus patients with nephritis was lymphopenia. Survival analysis showed that convulsion had no impact on patient and renal function outcomes in our pediatric lupus nephritis subjects. In conclusion, we found that lymphopenia is a predictive factor for convulsion occurrence in our patients and special attention to neurological status assessment may be needed in this situation. (author)

Type I Interferon in the Pathogenesis of Lupus

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Crow, Mary K.

2014-01-01

Investigations of patients with systemic lupus erythematosus (SLE) have applied insights from studies of the innate immune response to define type I interferon (IFN-I), with IFN-α the dominant mediator, as central to the pathogenesis of this prototype systemic autoimmune disease. Genetic association data identify regulators of nucleic acid degradation and components of TLR-independent, endosomal TLR-dependent, and IFN-I signaling pathways as contributors to lupus disease susceptibility. Together with a gene expression signature characterized by IFNI-induced gene transcripts in lupus blood and tissue, those data support the conclusion that many of the immunologic and pathologic features of this disease are a consequence of a persistent self-directed immune reaction driven by IFN-I and mimicking a sustained anti-virus response. This expanding knowledge of the role of IFN-I and the innate immune response suggests candidate therapeutic targets that are being tested in lupus patients. PMID:24907379

Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic Cells

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Reihl, Alec M.

2016-01-01

Dendritic cells (DC) play an important role in the pathogenesis of systemic lupus erythematosus (SLE), an autoimmune disease with multiple tissue manifestations. In this review, we summarize recent studies on the roles of conventional DC and plasmacytoid DC in the development of both murine lupus and human SLE. In the past decade, studies using selective DC depletions have demonstrated critical roles of DC in lupus progression. Comprehensive in vitro and in vivo studies suggest activation of DC by self-antigens in lupus pathogenesis, followed by breakdown of immune tolerance to self. Potential treatment strategies targeting DC have been developed. However, many questions remain regarding the mechanisms by which DC modulate lupus pathogenesis that require further investigations. PMID:27034965

Intravenous immunoglobulin therapy and systemic lupus erythematosus.

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Zandman-Goddard, Gisele; Levy, Yair; Shoenfeld, Yehuda

2005-12-01

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with diverse manifestations. We suggest that intravenous immunoglobulin (IVIg) therapy may be beneficial and safe for various manifestations in SLE. A structured literature search of articles published on the efficacy of IVIg in the treatment of SLE between 1983 and 2005 was conducted. We searched the terms "IVIg," "intravenous immunoglobulin," "lupus," "SLE," and "systemic lupus erythematosus." The various clinical manifestations of SLE that were reported to be successfully treated by IVIg in case reports include autoimmune hemolytic anemia, acquired factor VIII inhibitors, acquired von Willebrand disease, pure red cell aplasia, thrombocytopenia, pancytopenia, myelofibrosis, pneumonitis, pleural effusion, pericarditis, myocarditis, cardiogenic shock, nephritis, end-stage renal disease, encephalitis, neuropsychiatric lupus, psychosis, peripheral neuropathy, polyradiculoneuropathy, and vasculitis. The most extensive experience is with lupus nephritis. There are only a few case series of IVIg use in patients with SLE with various manifestations, in which the response rate to IVIg therapy ranged from 33 to 100%. We suggest that IVIg devoid of sucrose, at a dose of 2 g/kg over a 5-d period given uniformly and at a slow infusion rate in patients without an increased risk for thromboembolic events or renal failure, is a safe and beneficial adjunct therapy for cases of SLE that are resistant to or refuse conventional treatment. The duration of therapy is yet to be established. Controlled trials are warranted.

Anti-C1q antibodies in systemic lupus erythematosus

DEFF Research Database (Denmark)

Orbai, A-M; Truedsson, L; Sturfelt, G

2015-01-01

OBJECTIVE: Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study. METHODS: Information...... in combination with anti-dsDNA and low complement was the strongest serological association with renal involvement. These data support the usefulness of anti-C1q in SLE, especially in lupus nephritis....

Understanding lupus nephritis: diagnosis, management, and treatment options

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Mok CC

2012-05-01

Full Text Available Chi Chiu MokDepartment of Medicine, Tuen Mun Hospital and Center for Assessment and Treatment of Rheumatic Diseases, Pok Oi Hospital, Hong Kong, ChinaAbstract: Systemic lupus erythematosus (SLE predominantly affects women in their reproductive years. Renal disease (glomerulonephritis is one of the most frequent and serious manifestations of SLE. Of the various histological types of lupus glomerulonephritis, diffuse proliferative nephritis carries the worst prognosis. Combined with high-dose prednisone, mycophenolate mofetil (MMF has emerged as a first-line immunosuppressive treatment, although data regarding the efficacy of MMF on the long-term preservation of renal function are forthcoming. Cyclophosphamide is reserved for more severe forms of lupus nephritis, such as crescentic glomerulonephritis with rapidly deteriorating renal function, patients with significant renal function impairment at presentation, and refractory renal disease. Evidence for the calcineurin inhibitors in the treatment of lupus nephritis is weaker, and it concerns patients who are intolerant or recalcitrant to other agents. While further controlled trials are mandatory, B cell modulation therapies, such as rituximab, belimumab and epratuzumab are confined to refractory disease. Non-immunosuppressive measures, such as angiotensin-converting enzyme inhibitors, vigorous blood pressure control, prevention and treatment of hyperlipidemia and osteoporosis, are equally important.Keywords: lupus, nephritis, nephropathy, glomerulonephritis, treatment, therapy, women

Cambios en las formas de consumo en las sociedades tradicionales y conflictos con el mercado de trabajo. Osorno, Chile (1880-1905

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Jorge Muñoz Sougarret

2012-12-01

Full Text Available En 1905 se daba por terminado el experimento agro industrial más arriesgado del diecinueve chileno, nacido de la comunión de colonos germanos y un terreno desatendido por el Estado nacional. La frontera sur araucana reunió intereses, potencialidades y capitales que le permitieron desarrollarse fuera del marco tradicional del Chile central; instituciones y personas naturales se sorprendían y maravillaban al momento de presenciar la complejidad y racionalidad del modelo fabril erigido por los germano-descendientes en la frontera sur de Chile. Para contemporáneos e historiadores, la abrupta crisis y desaparición del experimento puede ser reducida a un factor, la entrada del Estado chileno a la región. Sin méritos de desestimar tal hipótesis, nos hemos de centrar en el estudio de la crisis desde el ámbito laboral, aquello nos permitiría relocalizar su estudio desde los factores externos, a las condiciones, y condicionantes, internos de la fábrica. Posibilitándonos insertar al trabajador en un mercado de consumo en expansión que colisionaba con las políticas laborales y salariales utilizadas por tales manufacturas. Escenario que fraccionó a la industria y la debilitó frente a la aparición de un tercer sujeto, el Estado.

Lack of recording of systemic lupus erythematosus in the death certificates of lupus patients.

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Calvo-Alén, J; Alarcón, G S; Campbell, R; Fernández, M; Reveille, J D; Cooper, G S

2005-09-01

To determine to what extent the diagnosis of systemic lupus erythematosus (SLE) in deceased lupus patients is under-reported in death certificates, and the patient characteristics associated with such an occurrence. The death certificates of 76 of the 81 deceased SLE patients from two US lupus cohorts (LUMINA for Lupus in Minorities: Nature vs Nurture and CLU for Carolina Lupus Study), including 570 and 265 patients, respectively, were obtained from the Offices of Vital Statistics of the states where the patients died (Alabama, Georgia, North Carolina, South Carolina, Tennessee and Texas). Both cohorts included patients with SLE as per the American College of Rheumatology criteria, aged > or =16 yr, and disease duration at enrolment of < or =5 yr. The median duration of follow-up in each cohort at the time of these analyses ranged from 38.1 to 53.0 months. Standard univariable analyses were performed comparing patients with SLE recorded anywhere in the death certificate and those without it. A multivariable logistic regression model was performed to identify the variables independently associated with not recording SLE in death certificates. In 30 (40%) death certificates, SLE was not recorded anywhere in the death certificate. In univariable analyses, older age was associated with lack of recording of SLE in death certificates [mean age (standard deviation) 50.9 (15.6) years and 39.1 (18.6) yr among those for whom SLE was omitted and included on the death certificates, respectively, P = 0.005]. Patients without health insurance, those dying of a cardiovascular event and those of Caucasian ethnicity were also more likely to be in the non-recorded group. In the multivariable analysis, variables independently associated with not recording SLE as cause of death were older age [odds ratio = (95% confidence interval) 1.043 (1.005-1.083 per yr increase); P = 0.023] and lack of health insurance [4.649 (1.152-18.768); P = 0.031]. A high proportion of SLE diagnoses are not

Densidad mineral ósea en una muestra de jóvenes chilenos practicantes de diversas modalidades deportivas

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Rossana Gómez-Campos

2017-01-01

Full Text Available Objetivos: Objetivos: a Comparar la densidad mineral ósea de una muestra de jóvenes chilenos practicantes de diversas modalidades deportivas y b Analizar la densidad mineral ósea en función de la maduración biológica. Métodos: Se estudiaron 146 adolescentes de sexo masculino, con un rango de edad entre 10 a 18 años. Se organizaron cinco grupos de trabajo: Grupo control (escolares n= 40, Canotaje (n= 30, Ciclismo (n=14, Fútbol (n=28 y Natación (n=34. Se evaluó el peso, estatura, altura tronco-cefálica. Se calculó el índice de Masa Corporal y la maduración biológica por medio de años de pico de velocidad de crecimiento. La densidad mineral ósea de cuerpo total y el porcentaje de grasa corporal se determinó por medio de la absorciometría de rayos X de doble energía. Resultados: Los adolescentes que practicaban fútbol evidenciaron mayor densidad mineral ósea (1,23±0,12g/cm 2 en relación a los jóvenes del ciclismo (0,99±0,11g/cm 2 , canotaje (1,09±0,17g/cm 2 , natación (1,10±0,11g/cm 2 y al grupo control de escolares (1,04±0,14g/ cm 2 (p<0.001. Hubo diferencias entre los tres niveles de maduración biológica en las cuatro modalidades deportivas y en el grupo control (p<0.001. La mayor densidad mineral ósea en función de la maduración somática se observó en los futbolistas. Conclusión: Los adolescentes que practican fútbol evidenciaron mayor densidad mineral ósea con relación a las demás modalidades deportivas y con relación al grupo control, además la maduración somática juega un papel relevante en el incremento de densidad mineral ósea, en especial en los futbolistas. Los resultados sugieren desarrollar actividades físico- deportivas de alto impacto antes, durante y después de producirse la maduración biológica en adolescentes de edad escolar.

Radiologically detectable musculoskeletal involvement in systemic lupus erythematosus; Afectacion musculoesquelitca con expresion radiologica en el lupus eritematoso sistemico

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Jimenez, M. M.; Manjon, P.; Diaz de Bustamante, T.; Galindo, M.; Buj, M. J.; Cabezudo, J. [Hospital Doce de Octubre de Madrid (Spain)

2000-07-01

We show a wide spectrum of musculoskeletal involvement in systemic lupus erythematosus (SLE) that can be detected by radiological examination. We determined the indications of different imaging techniques in the diagnosis and follow-up of this disease. We reviewed the clinical and radiological histories of 37 patients diagnosed as having SLE on the basis of serological and musculoskeletal criteria. We assessed the personal data of each patient, the association of the disease with autoimmune processes, serology, treatment and radiological findings using plain X ray, ultrasound, computed tomography (CT) and magnetic resonance (MR). Of the 37 cases reviewed, only ten presented changes in one or more of the imaging studies performed. the most common radiological finding was symmetric poly arthritis located at different sites. Other signs included avascular necrosis (late and early), inflammation and tendon and/or ligament rupture, nonerosive deforming arthropathies , soft tissue calcifications and arthritis (staphylococcal and tuberculous). A direct correlation was established between the anticardiolipin antibody titer, steroid doses and avascular necrosis. In SLE, radiologically detectable osteoarticular lesions are uncommon. Symmetric polyarthritis is the earliest lesion and that occurring most frequently. Other signs do not appear as often, with the exception of osteonecrosis, which usually occurs late. It developed early and was unusually aggressive in two youths with elevated anticardiolipin antibody titers and substantial systemic involvement in our series. The contributions of ultrasound and MR in the assessment of musculoskeletal involvement in SLE are especially relevant in the study of inflammations and tendon rupture and in the management of avascular necrosis, respectively. (Author) 17 refs.

Unusual presentation of childhood Systemic Lupus Erythematosus

Science.gov (United States)

Kumar, Sathish; Agarwal, Indira

2007-01-01

Bullous systemic lupus erythematosus is a rare blistering condition with a distinctive combination of clinical, histological and immunopathologic features that together constitute a unique bullous disease phenotype. It is often associated with autoimmunity to type VII collagen. Here we report a child who presented with bullous systemic lupus erythematosus. Rapid resolution of the blisters occurred following treatment with dapsone. PMID:18028550

Biomarkers for CNS involvement in pediatric lupus

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Rubinstein, Tamar B; Putterman, Chaim; Goilav, Beatrice

2015-01-01

CNS disease, or central neuropsychiatric lupus erythematosus (cNPSLE), occurs frequently in pediatric lupus, leading to significant morbidity and poor long-term outcomes. Diagnosing cNPSLE is especially difficult in pediatrics; many current diagnostic tools are invasive and/or costly, and there are no current accepted screening mechanisms. The most complicated aspect of diagnosis is differentiating primary disease from other etiologies; research to discover new biomarkers is attempting to address this dilemma. With many mechanisms involved in the pathogenesis of cNPSLE, biomarker profiles across several modalities (molecular, psychometric and neuroimaging) will need to be used. For the care of children with lupus, the challenge will be to develop biomarkers that are accessible by noninvasive measures and reliable in a pediatric population. PMID:26079959

Neurological Sequelae of Lupus

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... psychological problems (including personality changes, paranoia, mania, and schizophrenia), seizures, transverse myelitis, and paralysis and stroke. Treatment There is no cure for lupus. Treatment is symptomatic. With a combination ...

Prevalence, incidence, and demographics of systemic lupus erythematosus and lupus nephritis from 2000 to 2004 among children in the US Medicaid beneficiary population.

Science.gov (United States)

Hiraki, Linda T; Feldman, Candace H; Liu, Jun; Alarcón, Graciela S; Fischer, Michael A; Winkelmayer, Wolfgang C; Costenbader, Karen H

2012-08-01

To investigate the nationwide prevalence, incidence, and sociodemographics of systemic lupus erythematosus (SLE) and lupus nephritis among children in the US Medicaid beneficiary population. Children ages 3 years to Classification of Diseases, Ninth Revision [ICD-9] code of 710.0 for SLE, each >30 days apart) were identified from the US Medicaid Analytic eXtract database from 2000 to 2004. This database contains all inpatient and outpatient Medicaid claims for 47 US states and the District of Columbia. Lupus nephritis was identified from ≥2 ICD-9 billing codes for glomerulonephritis, proteinuria, or renal failure, each recorded >30 days apart. The prevalence and incidence of SLE and lupus nephritis were calculated among Medicaid-enrolled children overall and within sociodemographic groups. Of the 30,420,597 Medicaid-enrolled children during these years, 2,959 were identified as having SLE. The prevalence of SLE was 9.73 (95% confidence interval [95% CI] 9.38-10.08) per 100,000 Medicaid-enrolled children. Among the children with SLE, 84% were female, 40% were African American, 25% were Hispanic, 21% were White, and 42% resided in the South region of the US. Moreover, of the children with SLE, 1,106 (37%) had lupus nephritis, representing a prevalence of 3.64 (95% CI 3.43-3.86) per 100,000 children. The average annual incidence of SLE was 2.22 cases (95% CI 2.05-2.40) and that of lupus nephritis was 0.72 cases (95% CI 0.63-0.83) per 100,000 Medicaid enrollees per year. The prevalence and incidence rates of SLE and lupus nephritis increased with age, were higher in girls than in boys, and were higher in all non-White racial/ethnic groups. In the current study, the prevalence and incidence rates of SLE among Medicaid-enrolled children in the US are high compared to studies in other populations. In addition, these data represent the first population-based estimates of the prevalence and incidence of lupus nephritis in the US to date. Copyright © 2012 by the American

Case Report: Systemic Lupus Erythematosus Presenting as Acute ...

African Journals Online (AJOL)

We hereby report a case of a 20 year‑old female who presented to us in an acute hypoadrenal state and was found to have Systemic lupus erythematosus with renal involvement. Patient was successfully managed with steroids and improved clinically. Keywords: Addison's disease, Autoimmune diseases, Systemic lupus ...

[Central nervous system involvement in systemic lupus erythematosus - diagnosis and therapy].

Science.gov (United States)

Szmyrka, Magdalena

Nervous system involvement in lupus belongs to its severe complications and significantly impacts its prognosis. Neuropsychiatric lupus includes 19 disease manifestations concerning both central and peripheral nervous system. This paper presents clinical aspects of central nervous system involvement in lupus. It reviews its epidemiology, risk factors and principles of diagnosis and therapy.

Progress Made in Lupus Diagnosis and Treatment | NIH MedlinePlus the Magazine

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... of this page please turn JavaScript on. Feature: Lupus Progress Made in Lupus Diagnosis and Treatment Past Issues / Spring 2014 Table ... W. Clark NIAMS For our readers who have lupus or are the loved ones of someone with ...

A multi-group confirmatory factor analyses of the LupusPRO between southern California and Filipino samples of patients with systemic lupus erythematosus.

Science.gov (United States)

Azizoddin, D R; Olmstead, R; Cost, C; Jolly, M; Ayeroff, J; Racaza, G; Sumner, L A; Ormseth, S; Weisman, M; Nicassio, P M

2017-08-01

Introduction Systemic lupus erythematosus (SLE) leads to a range of biopsychosocial health outcomes through an unpredictable and complex disease path. The LupusPRO is a comprehensive, self-report measure developed specifically for populations with SLE, which assesses both health-related quality of life and non-health related quality of life. Given its increasingly widespread use, additional research is needed to evaluate the psychometric integrity of the LupusPRO across diverse populations. The objectives of this study were to evaluate the performance of the LupusPRO in two divergent patient samples and the model fit between both samples. Methods Two diverse samples with SLE included 136 patients from an ethnically-diverse, urban region in southern California and 100 from an ethnically-homogenous, rural region in Manila, Philippines. All patients met the ACR classification criteria for SLE. Confirmatory factor analysis (CFAs) were conducted in each sample separately and combined to provide evidence of the factorial integrity of the 12 subscales in the LupusPRO. Results Demographic analyses indicated significant differences in age, disease activity and duration, education, income, insurance, and medication use between groups. Results of the separate CFAs indicated moderate fit to the data for the hypothesized 12-factor model for both the Manila and southern California groups, respectively [χ 2 (794) = 1283.32, p < 0.001, Comparative Fit Index (CFI) = 0.793; χ 2 (794) =1398.44, p < 0.001, CFI = 0.858]. When the factor structures of the LupusPRO in the southern California and Manila groups were constrained to be equal between the two groups, findings revealed that the factor structures of measured variables fit the two groups reasonably well [χ 2  (1697) = 2950.413, df = 1697, p < 0.000; CFI = 0.811]. After removing seven constraints and eight correlations suggested by the Lagrange multiplier test, the model fit improved

Propiedades psicométricas de tres escalas de evaluación del trastorno por déficit de atención con hiperactividad en escolares chilenos Psychometric properties of three rating scales for attention deficit hyperactivity disorder in Chilean students

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Alfonso Urzúa

2010-03-01

Full Text Available OBJETIVO: Evaluar en escolares chilenos la fiabilidad y la validez de tres escalas que miden el trastorno de déficit de atención con hiperactividad (TDAH: el inventario para déficit de atención (IDDA, la escala de evaluación del déficit de atención con hiperactividad (EDAH y la adaptación española de la escala para la gradación del déficit de atención con hiperactividad IV (EGDAH IV. MÉTODO: Estudio instrumental con los tutores (n = 612 y los profesores (n = 82 de una muestra intencional de 640 niños y niñas de 6 a 11 años de edad, estudiantes de establecimientos municipales públicos (n = 228; 35,6% del total; subvencionados (n = 200; 31,3% y privados (n = 212; 33,1% de la ciudad de Antofagasta, Chile. La validez de convergencia de los instrumentos de medición del TDAH se determinó mediante las pruebas de Stroop y de Wechsler. RESULTADOS: Las tres escalas evaluadas presentan niveles satisfactorios de consistencia interna (coeficiente alfa de Cronbach de 0,88 a 0,97 en las escalas y de 0,76 a 0,97 en las dimensiones y una estructura factorial acorde a la teórica en la mayoría de las dimensiones evaluadas, aunque solo la EGDAH IV con los tutores y los profesores, y el IDDA con los profesores mostraron índices de ajuste comparativo y de ajuste relativo superiores a 0,90. Se encontraron diferencias significativas según la edad, el sexo y el tipo de informante (tutor o profesor. CONCLUSIÓN: El IDDA y la EGDAH IV cumplieron favorablemente con todos los criterios de fiabilidad y validez, por lo que se pueden aplicar para el tamizaje y el diagnóstico en la población chilena. La escala EGDAH IV presentó las mejores propiedades psicométricas por su confiabilidad y validez.OBJECTIVE: To assess, among Chilean students, the reliability and validity of three scales that measure attention deficit hyperactivity disorder (ADHD: the ADHD Rating Scale-IV (ADHD-IV; the scale for evaluating attention deficit disorder with hyperactivity

Biomarkers in systemic lupus erythematosus: challenges and prospects for the future

Science.gov (United States)

Kao, Amy H.; Manzi, Susan; Ahearn, Joseph M.

2013-01-01

The search for lupus biomarkers to diagnose, monitor, stratify, and predict individual response to therapy is currently more intense than ever before. This effort is essential for several reasons. First, epidemic overdiagnosis and underdiagnosis of lupus, even by certified rheumatologists, leads to errors in therapy with concomitant side effects which may be more serious than the disease itself. Second, identification of lupus flares remains as much an art as it is a science. Third, the capacity to stratify patients so as to predict those who will develop specific patterns of organ involvement is not currently possible but would potentially lead to preventive therapeutic strategies. Fourth, only one new drug for the treatment of lupus has been approved by the US Food and Drug Administration in over 50 years. A major obstacle in this pipeline is the dearth of biomarkers available to prove a patient has responded to an experimental therapeutic intervention. This review will summarize the challenges faced in the discovery and validation of lupus biomarkers, the most promising lupus biomarkers identified to date, and the promise of future directions. PMID:23904865

Survival in systemic lupus erythematosus, 1995-2010

DEFF Research Database (Denmark)

Voss, A; Laustrup, H; Hjelmborg, J

2013-01-01

ObjectiveThe objective of this paper is to investigate survival and causes of death in a Danish lupus population.MethodsTwo hundred and fifteen SLE patients (94% Caucasians) were followed prospectively for up to 16 years. Thirty-eight patients died. Survival rate and causes of death were analysed......%) and malignancies (13%). Deaths due to infections and active SLE were rare and predominated within the first seven years after diagnosis and before age 40, while cardiovascular deaths prevailed after 20 years' follow-up.ConclusionThis study shows that despite progress in lupus management, including direct access...... to specialized hospital care and increased use of hydroxychloroquine, mortality in lupus patients is still increased. Main causes of death were active disease and infections among the young and newly diagnosed, while cardiovascular deaths prevailed in longstanding disease....

Systemic Lupus Erythematosus: Primary Care Approach to Diagnosis and Management.

Science.gov (United States)

Lam, Nguyet-Cam Vu; Ghetu, Maria V; Bieniek, Marzena L

2016-08-15

Systemic lupus erythematosus is an autoimmune disease that affects many systems, including the skin, musculoskeletal, renal, neuropsychiatric, hematologic, cardiovascular, pulmonary, and reproductive systems. Family physicians should be familiar with the manifestations of lupus to aid in early diagnosis, monitoring patients with mild disease, recognizing warning signs that require referral to a rheumatologist, and helping to monitor disease activity and treatment in patients with moderate to severe disease. The American College of Rheumatology has 11 classification criteria for lupus. If a patient meets at least four criteria, lupus can be diagnosed with 95% specificity and 85% sensitivity. All patients with lupus should receive education, counseling, and support. Hydroxychloroquine is the cornerstone of treatment because it reduces disease flares and other constitutional symptoms. Low-dose glucocorticoids can be used to treat most manifestations of lupus. The use of immunosuppressive and cytotoxic agents depends on the body systems affected. Patients with mild disease that does not involve major organ systems can be monitored by their family physician. Patients with increased disease activity, complications, or adverse effects from treatment should be referred to a rheumatologist. To optimize treatment, it is important that a rheumatologist coordinate closely with the patient's family physician to improve chronic care as well as preventive health services.

Adaptaciones metodológicas para el análisis del discurso de niños con discapacidad intelectual: narrando sin lenguaje

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Dominique Manghi Haquin

2016-01-01

Full Text Available Dada la necesidad de comprender las formas de comunicación de personas con discapacidad intelectual para favorecer su participación social, este estudio trata la narración como una instancia discursiva autogestionada más allá del lenguaje. El objetivo es sistematizar una metodología que permita explorar su discurso narrativo usando una perspectiva multimodal. La descripción corresponde a las narraciones de quince escolares chilenos con discapacidad intelectual y escaso desarrollo de la lengua oral, pero con intención narrativa. A partir de la adaptación de una tarea de recontado, se analizan discursivamente sus producciones multimodales y se observan narraciones enfocadas en las acciones de los personajes y construidas a partir de una combinación de recursos comunicativos. La metodología resulta apropiada para dar cuenta de los recursos narrativos usados por estos estudiantes en los primeros años escolares y legitima sus estrategias narrativas, lo cual contribuye al desarrollo de la disciplina educación especial y al estudio de la comunicación desde una mirada inclusiva.

ENDOCARDITIS IN SYSTEMIC LUPUS ERYTHEMATOSUS

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AMEL Harzallah

2017-04-01

Full Text Available Endocarditis is one of the most prevalent forms of cardiac involvement in patients with lupus, as it is considered as one a life-threatening complication. Libman-Sacks endocarditis is common. Infective endocarditis can also cause complications within immunocompromised patients. The aim of this study is to determine particularities of endocarditis in patients with lupus and to look for distinguishing features between infectious or immunological origin. A retrospective study was conducted on patients with lupus presenting endocarditis. Lupus was diagnosed according to the American college of rheumatology criteria. The diagnosis of endocarditis was made based on the modified Duke criteria. The present case report studies seven cases of endocarditis. Six of these patients are women and the other one is a man. They are aged meanly of 29.4 years (extremes: 20-36. Fever was present in all the cases with a new cardiac murmur in six cases and a modification of its intensity in one case. Biologic inflammatory syndrome was present in six cases. Cardiac ultrasound performed in six cases made the diagnosis of endocarditis which involved the left heart valves in five cases and the right heart valves in one case. Valvular insufficiency was identified in six patients. The valve involvement was mitral in two cases, mitro-aortic in two others, aortic in the fifth one and tricuspid in the sixth one. Endocarditis was infectious in 4 cases, thanks to positive blood culture. The germs identified were gram negative bacilli in two cases, anaerobic organism in one case and gram positive cocci in one case. Candida albicans was isolated in one case. Libman-Sacks endocarditis was objectified in three cases. A combination of Libman-Sacks endocarditis with infectious endocarditis was diagnosed in one case. The treatment consisted of antibiotics in four cases with surgery in two cases. The outcome was favorable in five cases and fatal in the two others. Endocarditis in lupus

Neurological Disease in Lupus: Toward a Personalized Medicine Approach

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McGlasson, Sarah; Wiseman, Stewart; Wardlaw, Joanna; Dhaun, Neeraj; Hunt, David P. J.

2018-01-01

The brain and nervous system are important targets for immune-mediated damage in systemic lupus erythematosus (SLE), resulting in a complex spectrum of neurological syndromes. Defining nervous system disease in lupus poses significant challenges. Among the difficulties to be addressed are a diversity of clinical manifestations and a lack of understanding of their mechanistic basis. However, despite these challenges, progress has been made in the identification of pathways which contribute to neurological disease in SLE. Understanding the molecular pathogenesis of neurological disease in lupus will inform both classification and approaches to clinical trials. PMID:29928273

Neurological Disease in Lupus: Toward a Personalized Medicine Approach.

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McGlasson, Sarah; Wiseman, Stewart; Wardlaw, Joanna; Dhaun, Neeraj; Hunt, David P J

2018-01-01

The brain and nervous system are important targets for immune-mediated damage in systemic lupus erythematosus (SLE), resulting in a complex spectrum of neurological syndromes. Defining nervous system disease in lupus poses significant challenges. Among the difficulties to be addressed are a diversity of clinical manifestations and a lack of understanding of their mechanistic basis. However, despite these challenges, progress has been made in the identification of pathways which contribute to neurological disease in SLE. Understanding the molecular pathogenesis of neurological disease in lupus will inform both classification and approaches to clinical trials.

Kutan lupus erythematosus

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Sandreva, Tatjana; Voss, Anne; Bygum, Anette

2016-01-01

Cutaneous lupus erythematosus (LE) is an autoimmune disease. The most common clinical forms are acute cutaneous LE (ACLE), subacute cutaneous LE (SCLE) and discoid LE (DLE). Cutaneous LE, mainly ACLE, can be the first sign of systemic LE (SLE). DLE and SCLE are less associated with development...

Effective Self-Management Interventions for Patients With Lupus: Potential Impact of Peer Mentoring.

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Williams, Edith M; Egede, Leonard; Faith, Trevor; Oates, James

2017-06-01

Systemic lupus erythematosus (SLE) is associated with significant mortality, morbidity and cost for the individual patient and society. In the United States, African Americans (AAs) have 3-4 times greater prevalence of lupus, risk of developing lupus at an earlier age and lupus-related disease activity, organ damage and mortality compared with whites. Evidence-based self-management interventions that incorporate both social support and health education have reduced pain, improved function and delayed disability among patients with lupus. However, AAs and women are still disproportionately affected by lupus. This article presents the argument that peer mentoring may be an especially effective intervention approach for AA women with SLE. SLE peers with a track record of success in lupus management and have a personal perspective that clinicians often lack. This commonality and credibility can establish trust, increase communication and, in turn, decrease disparities in healthcare outcomes. Copyright © 2017 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

Echocardiographic evaluation of patients with systemic lupus erythematosus

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Hameed, S.; Malik, L.M.

2007-01-01

Cardiac disease occurs in various forms and is a common cause of death in systemic lupus erythematosus. The objective was to detect cardiac abnormalities by transthoracic echocardiography and determine their association in SLE patients. We conducted a transthoracic echocardiographic study in 48 inpatients with systemic lupus erythematosus. Clinical and serological evaluation to confirm the diagnosis of lupus was done in all patients. There were 44 women (91.6%) and 4 men with a mean age of 26 years. Anti ds DNA was positive in 34 patients (68.75%). Transthoracic echocardiography revealed abnormality in 28 patients (58.33%). Of these, 16 patients (57%) had pericardial involvement with variable amount of effusion. Twelve patients (43%) had some valvular involvement and some degree of myocardial systolic dysfunction was found in 12 patients (43%). Only 4 patients (14%) had all three abnormalities. Anti ds DNA was positive in 71% of patients with cardiac abnormalities. Cardiac involvement is common in patients with systemic lupus erythematosus. Serological abnormalities had an association with cardiac abnormalities, and were found to be more prevalent in young patients. (author)

Kutan lupus erythematosus

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Sandreva, Tatjana; Voss, Anne; Bygum, Anette

2016-01-01

Cutaneous lupus erythematosus (LE) is an autoimmune disease. The most common clinical forms are acute cutaneous LE (ACLE), subacute cutaneous LE (SCLE) and discoid LE (DLE). Cutaneous LE, mainly ACLE, can be the first sign of systemic LE (SLE). DLE and SCLE are less associated with development of...... hydroxychloroquine....

Therapeutic strategies evaluated by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) Core Set Questionnaire in more than 1000 patients with cutaneous lupus erythematosus

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Sigges, Johanna; Biazar, Cyrus; Landmann, Aysche

2013-01-01

The aim of this prospective, cross-sectional, multicentre study performed by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) was to investigate different therapeutic strategies and their efficacies in cutaneous lupus erythematosus (CLE) throughout Europe. Using the EUSCLE Core Set...... Questionnaire, topical and systemic treatment options were analysed in a total of 1002 patients (768 females and 234 males) with different CLE subtypes. The data were correlated with the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) and the criteria of the American College...... of Rheumatology (ACR) for the classification of systemic lupus erythematosus. Sunscreens were applied by 84.0% of the study cohort and showed a high efficacy in preventing skin lesions in all disease subtypes, correlating with a lower CLASI activity score. Topical steroids were used in 81.5% of the patients...

Cutaneous manifestations of systemic lupus erythematosus in a tertiary referral center

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Kole Alakes

2009-01-01

Full Text Available Background : Systemic lupus erythematosus (SLE is an autoimmune disease with multiorgan involvement. The skin is the second most commonly affected organ. SLE with skin lesions can produce considerable morbidity resulting from painful skin lesions, alopecia, disfigurement, etc. Skin lesions in patients with lupus may be specific (LE specific or may be non specific (LE non specific. Acute cutaneous LE (Lupus specific has a strong association with systemic disease and non-specific skin lesions always indicate disease activity for which patients present to rheumatologists and internists. Therefore, a thorough understanding of the cutaneous manifestations of SLE is essential for most efficient management. Aims: The aims of this study were to evaluate the patterns and prevalence of skin lesions in patients with SLE and to assess the relationship between skin lesions and other systemic involvement. Materials and Methods: At the Department of Rheumatology and Clinical Immunology, IPGME&R in Kolkata, 150 patients with SLE fulfilling the clinical and laboratory criteria of the American Rheumatology Association (updated 1982 were examined and followed-up for cutaneous manifestations between January 2002 and January 2007. Results: Skin lesions were important clinical features. About 45 patients (30% presented with skin lesions although all patients had skin lesions during the follow-up period. Skin changes noted were as follows: Lupus specific lesions: malar rash in 120 patients (80%, photosensitive dermatitis in 75 patients (50%, generalized maculopapular rash in 40 patients (26.67%, discoid rash in 30 patients (20%, subacute cutaneous lupus erythematosus (SCLE in 5 patients (3.34%, lupus profundus in 5 patients (3.34%. The lupus non-specific lesions were non-scarring alopecia in 130 patients (86.67%, oral ulcers in 85 patients (56.67%, vasculitic lesions in 50 patients (33.34%, bullous lesions in 15 patients (10%, Raynaud′s phenomenon in 10 patients (6

Total lymphoid irradiation in refractory systemic lupus erythematosus

International Nuclear Information System (INIS)

Ben-Chetrit, E.; Gross, D.J.; Braverman, A.; Weshler, Z.; Fuks, Z.; Slavin, S.; Eliakim, M.

1986-01-01

In two patients with systemic lupus erythematosus, conventional therapy was considered to have failed because of persistent disease activity and unacceptable side effects. Both were treated with total lymphoid irradiation without clinical benefit, despite adequate immunosuppression as documented by markedly reduced numbers of circulating T lymphocytes and T-lymphocyte-dependent proliferative responses in vitro. The first patient developed herpes zoster, gram-negative septicemia, neurologic symptoms, and deterioration of lupus nephritis. The second patient developed massive bronchopneumonia, necrotic cutaneous lesions, and progressive nephritis and died 2 weeks after completion of radiotherapy. These observations, although limited to two patients, indicate that total lymphoid irradiation in patients with severe systemic lupus erythematosus should be regarded as strictly experimental

The existential experience of everyday life with systemic lupus erythematosus

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Larsen, Janni Lisander; Hall, Elisabeth; Jacobsen, Søren

2018-01-01

with systemic lupus erythematosus and of various ages, disease durations and severities were undertaken from September 2013 - October 2015. Data were analysed following van Manen's phenomenological approach and using drawing as an interpretive tool. Findings: The main existential experience was interpreted......Aim: To explore from the perspective of women the nature of basic existential conditions while living with systemic lupus erythematosus. Background: Systemic lupus erythematosus has an unpredictable disease course and is documented to cause an existential rearrangement of life. The significance...... of changes in existential conditions and related experiences are unclear in the context of nursing and women with systemic lupus erythematosus. Design: A qualitative design guided by Van Manen's hermeneutic-phenomenological methodology. Method: Individual in-depth interviews with 15 women diagnosed...

Drug-induced lupus erythematosus

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... Tsokos GC, ed. Systemic Lupus Erythematosus . Philadelphia, PA: Elsevier; 2016:chap 54. Habif TP. Connective tissue diseases. ... TP, ed. Clinical Dermatology . 6th ed. Philadelphia, PA: Elsevier; 2016:chap 17. Kumar V, Abbas AK, Aster ...

Systemic lupus erythaematosus in a multiethnic US cohort (LUMINA) LIII: disease expression and outcome in acute onset lupus.

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Bertoli, A M; Vilá, L M; Reveille, J D; Alarcón, G S

2008-04-01

To determine the features associated with acute onset systemic lupus erythaematosus (SLE). A total of 631 SLE patients from LUMINA (for "lupus in minority populations: nature vs nurture"), a multiethnic (Hispanics, African-Americans and Caucasians) cohort, were studied. Acute disease onset was defined as the accrual of > or = 4 American College of Rheumatology (ACR) criteria for the classification of SLE in < or = 4 weeks. Socioeconomic demographic features, clinical manifestations, disease activity, damage accrual, mortality, autoantibodies, HLA class II and FCGR alleles, behavioural/psychological variables were compared between patients with acute and insidious disease onset by univariable (chi(2) and Student t test) and multivariable (stepwise logistic regression) analyses. A total of 94 (15%) patients had acute disease onset. In the multivariable analysis, patients with acute onset lupus had more renal involvement (odds ratio (OR) = 1.845, 95% CI 1.076-3.162; p = 0.026) and higher disease activity (OR = 1.057, 95% CI 1.005-1.112; p = 0.030). By contrast, age (OR = 0.976, 95% CI 0.956-0.997; p = 0.025), education (OR = 0.901, 95% CI 0.827-0.983, p = 0.019), health insurance (OR = 0.423, 95% CI 0.249-0.718; p = 0.001) and skin involvement (OR = 0.346, 95% CI 0.142-0.843; p = 0.019) were negatively associated with acute onset lupus. No differences were found regarding the serological, genetic and behavioural/psychological features; this was also the case for damage accrual and mortality. Patients with acute onset lupus seem to be younger, have a lower socio-economic status and display more severe disease in terms of clinical manifestations and disease activity. However, intermediate (damage) and long-term (mortality) outcomes appear not to be influenced by the type of disease onset in SLE.

[Clinical guideline for the treatment of lupus nephritis and single-centre results of mycofenolate mofetil among patients with lupus nephritis in the National Institute of Rheumatology and Physiotherapy, Budapest].

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Szabó, Melinda Zsuzsanna; Kiss, Emese

2016-08-01

The authors present the latest guideline for the treatment of lupus nephritis and their own single-centre results with mycofenolate mofetil treated lupus nephritis. Lupus nephritis and mainly its proliferative form is a frequent and potentially life-threatening manifestation of systemic lupus erythematosus that can lead to end-stage renal disease. The treatment of lupus nephritis greatly improved in the last decades; mycofenolate mofetil has become an alternative of cyclophosphamide both in remission induction and as a maintenance regimen as well in the treatment of Class III and IV glomerulonephritis. The authors ordered mycofenolate mofetil for 25 patients with lupus nephritis so far. Histologically most of them had Class III (A/C) or IV (A) glomerulonephritis (30-30%), and only 16% of the patients had renal impairment at that time. Mycofenolate mofetil given after glucocorticoid and cyclophosphamide induction therapy reduced the daily proteinuria from 3.18 grs to 1.06 grs. Complete remission could be achieved in 24% and partial remission in 48% of the patients. The authors conclude that mycofenolate mofetil is effective in the therapy of lupus nephritis. Orv. Hetil., 2016, 157(35), 1385-1393.

Propuestas para la formación en educación en medios en profesores chilenos Criteria of Media Education Program for Chilean teachers: A proposal for Continuous Training

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María del Mar de Fontcuberta Balaguer

2009-03-01

Full Text Available Este trabajo, desarrollado por un grupo de investigación chileno, expone los resultados de una investigación sobre la presencia de la educación en medios en el currículum de la enseñanza media chilena, los problemas que plantea y la formación y actitudes de los profesores de Lengua Castellana y Comunicación en ese ámbito. Para su análisis adopta las definiciones y parámetros contemplados por la UNESCO en Viena (1999 y Sevilla (2002 que indican, entre otros aspectos, que la educación en medios trata sobre la enseñanza y el aprendizaje «con» y «sobre» los medios, más que «a través» de los medios. El estudio concluye con una propuesta para implementar la formación continua de profesores en ese campo. The article explains the results of a research about Media Education in Chilean Secondary School curriculum, its problems, and training and attitudes of teachers of Spanish Language and Communication. The analysis applies definitions and parameters adopted by UNESCO in Viena (1999 and Seville (2002 which indicate that Media Education means to teach and learn «with»» and «about» media more than «through» media. It proposes a schedule for continuous training of teachers in this field.

[Biological disturbances during the lupus-associated pancreatitis: case report].

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Sayagh, Sanae; Benchekroun, Leila; Bouabdellah, Mounya; Jaouhar, Nezha; El Aoufi, Farida; El Oufir, Fatiha; Alaoui, Meryem; Adnaoui, Mohammed; Chabraoui, Layachi

2015-01-01

We report in this paper the case of female patient, hypertriglyceridemia associated with milky serum and hyperglycemia have been the alarm signal of a lupus-associated pancreatitis, the confirmation of this entity was done with elevated rate of serum lipase activity. It is about a 33 years age female. She has as unique antecedent a lupus diagnosed on January of the same. The patient was admitted on august 2013 for another episode of lupus associated to the lower lamb edema with a rate of C3 at 0.4 g/L (0.82-1,93) and C4 at 0.05 g/L (0.15-0.57). One day after the beginning of the corticotherapy, the patient presented hyperthermia, ataxis and behavior troubles, epigastric and articular pains and vomiting. Biochemical tests found hyperglycemia at 38.9 mmol/L (3.9-6.1), dyslipidemia with hypertriglyceridemia at 15.7 mmol/L (0.3-1.7) and total cholesterol rate at 5.2 mmol/L (<5.2) associated with milky serum. Haematological tests objective normocytic normochromic anemia with 81 g/L of hemoglobin, lymphopenia at 0.88 G/L and normal platelet rate. Lupus associated pancreatitis was suggested and confirmed biologically with an hyperlipasemia at 180 UI/L (8-78) and radiologicaly with the image of focal hepatic steatosis. We conclude that on the presence of lupus, gastrointestinal and/or biological signs must motivate the measurement of the serum lipase activity as quickly as possible to assess the diagnosis of lupus-associated pancreatitis.

Systemic lupus erythematosus presenting as morbid jealousy.

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Ravindran, A.; Carney, M. W.; Denman, A. M.

1980-01-01

A patient fulfilling the diagnostic criteria for systemic lupus erythematosus and presenting with morbid jealousy is described. There was evidence of cerebral lupus. Her physical and mental symptoms responded to a combination of chlorpromazine and steroids. The morbid mental process was probably caused by her physical condition while the content of her disordered thought and behaviour was determined by her introverted premorbid personality, religiosity, unhappy childhood experiences and frustrated desire for children. PMID:7413541

ACUTE RESPIRATORY DISEASE AS THE DEBUT OF SYSTEMIC LUPUS ERYTHEMATOSUS

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A. Yu. Ischenko

2015-01-01

Full Text Available Systemic lupus erythematosus — a chronic autoimmune disease that is often associated with infectious processes. The paper presents two clinical cases of systemic lupus erythematosus , debuted with acute respiratory infection.

Factors related to outcomes in lupus-related protein-losing enteropathy.

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Lim, Doo-Ho; Kim, Yong-Gil; Bae, Seung-Hyeon; Ahn, Soomin; Hong, Seokchan; Lee, Chang-Keun; Yoo, Bin

2015-11-01

Protein-losing enteropathy (PLE), characterized by severe hypoalbuminemia and peripheral edema, is a rare manifestation of systemic lupus erythematosus. This present study aimed to identify the distinctive features of lupus-related PLE and evaluate the factors related to the treatment response. From March 1998 to March 2014, the clinical data of 14 patients with lupus PLE and seven patients with idiopathic PLE from a tertiary center were reviewed. PLE was defined as a demonstration of protein leakage from the gastrointestinal tract by either technetium 99m-labelled human albumin scanning or fecal α1-antitrypsin clearance. A positive steroid response was defined as a return of serum albumin to ≥ 3.0 g/dL within 4 weeks after initial steroid monotherapy, and remission as maintenance of serum albumin ≥ 3.0 g/dL for at least 3 months. A high serum total cholesterol level was defined as a level of ≥ 240 mg/dL. The mean age of the lupus-related PLE patients was 37.0 years, and the mean follow-up duration was 55.8 months. Significantly higher erythrocyte sedimentation rate and serum total cholesterol levels were found for lupus PLE than for idiopathic PLE. Among the 14 patients with lupus PLE, eight experienced a positive steroid response, and the serum total cholesterol level was significantly higher in the positive steroid response group. A positive steroid response was associated with an initial high serum total cholesterol level and achievement of remission within 6 months. In lupus-related PLE, a high serum total cholesterol level could be a predictive factor for the initial steroid response, indicating a good response to steroid therapy alone.

Childhood lupus nephritis: 12 years of experience from a developing country's perspective.

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Samanta, Moumita; Nandi, Madhumita; Mondal, Rakesh; Hazra, Avijit; Sarkar, Sumatra; Sabui, Tapas; Kundu, Chanchal Kumar; Biswas, Arnab

2017-09-01

To assess the long-term outcome of lupus nephritis in children with systemic lupus erythematosus followed up over 12 years at a tertiary care teaching hospital in Eastern India. This is a retrospective observational study of the clinicopathological presentation, management, and outcome in 46 children with lupus nephritis over a period of 12 years at a tertiary teaching hospital in Eastern India. Mortality was compared between different lupus classes and therapy groups with Kaplan-Meier analysis and log-rank test. The incidence of lupus nephritis was 58.97% [95% confidence interval (CI) 48.06%-59.89%] with the mean age at presentation being 10.2±2.43 years (range 5.5-14.5) years. Majority belonged to class IV (30.43%), followed by class II (26.91%), class III (23.91), and class V (8.70%). Outcome analysis of children with lupus nephritis over 12 years revealed that 24 (52.17%) achieved complete remission of disease activity, 5 attained partial remission, 4 continued to have active disease, 5 developed end-stage renal disease (ESRD), and 8 died. Overall mortality thus observed was 17.39% with septicemia in the background of ESRD being the commonest cause. No significant difference in mortality was observed between different lupus nephritis classes or therapy arm groups. The study throws light on various aspects of lupus nephritis and their long-term outcome patterns in children from developing countries such as India.

Autologous Fat Transfer in a Patient with Lupus Erythematosus Profundus

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Jimi Yoon

2012-10-01

Full Text Available Lupus erythematosus profundus, a form of chronic cutaneous lupus erythematosus, is a rare inflammatory disease involving in the lower dermis and subcutaneous tissues. It primarily affects the head, proximal upper arms, trunk, thighs, and presents as firm nodules, 1 to 3 cm in diameter. The overlying skin often becomes attached to the subcutaneous nodules and is drawn inward to produce deep, saucerized depressions. We present a rare case of lupus erythematosus profundus treated with autologous fat transfer.

Recent insights into the genetic basis of systemic lupus erythematosus

OpenAIRE

Moser, Kathy L.; Kelly, Jennifer A.; Lessard, Christopher J.; Harley, John B.

2009-01-01

Genetic variation was first shown to be part of the cause of systemic lupus erythematosus (SLE or lupus) in the 1970s with associations in the human leukocyte antigen (HLA) region. Almost four decades later, and with the help of increasingly powerful genetic approaches, more than 25 genes are now known to contribute to the mechanisms that predispose individuals to lupus. Over half of these loci have been discovered in the past two years, underscoring the extraordinary success of recent genome...

Speckle tracking echocardiography in acute lupus myocarditis: comparison to conventional echocardiography

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Riëtte Du Toit

2017-07-01

Full Text Available Aims: Lupus myocarditis occurs in 5–10% of patients with systemic lupus erythematosus (SLE. No single feature is diagnostic of lupus myocarditis. Speckle tracking echocardiography (STE can detect subclinical left ventricular dysfunction in SLE patients, with limited research on its utility in clinical lupus myocarditis. We report on STE in comparison to conventional echocardiography in patients with clinical lupus myocarditis. Methods and results: A retrospective study was done at a tertiary referral hospital in South Africa. SLE patients with lupus myocarditis were included and compared to healthy controls. Echocardiographic images were reanalyzed, including global longitudinal strain through STE. A poor echocardiographic outcome was defined as final left ventricular ejection fraction (LVEF <40%. 28 SLE patients fulfilled the criteria. Global longitudinal strain correlated with global (LVEF: r = −0.808; P = 0.001 and regional (wall motion score: r = 0.715; P < 0.001 function. In patients presenting with a LVEF ≥50%, global longitudinal strain (P = 0.023, wall motion score (P = 0.005 and diastolic function (P = 0.004 were significantly impaired vs controls. Following treatment, LVEF (35–47% (P = 0.023 and wall motion score (1.88–1.5 (P = 0.017 improved but not global longitudinal strain. Initial LVEF (34%; P = 0.046 and global longitudinal strain (−9.5%; P = 0.095 were lower in patients with a final LVEF <40%. Conclusions: This is the first known report on STE in a series of patients with clinical lupus myocarditis. Global longitudinal strain correlated with regional and global left ventricular function. Global longitudinal strain, wall motion score and diastolic parameters may be more sensitive markers of lupus myocarditis in patients presenting with a preserved LVEF ≥50%. A poor initial LVEF and global longitudinal strain were associated with a persistent LVEF <40%. Echocardiography is a non-invasive tool with diagnostic and

The systemic lupus erythematosus travel burden survey: baseline data among a South Carolina cohort.

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Williams, Edith M; Ortiz, Kasim; Zhang, Jiajia; Zhou, Jie; Kamen, Diane

2016-04-29

Many studies on the impact of systemic lupus erythematosus or lupus have identified patient travel costs as being problematic. We administered a survey that examined the impact of self-rated travel burden on lupus patients. The systemic lupus erythematosus travel burden survey included 41 patients enrolled in the systemic lupus erythematosus database project at the Medical University of South Carolina. Most participants reported that travel caused medications to be discontinued or appointments to be missed. In unadjusted logistic regressions of the relationship between these outcomes and medical travel burden, both distance to rheumatologists and time to lupus medical care were significant. Our findings suggest that more research is needed to examine the influence of travel burden among this population, but data from this report could help to inform physicians, academic researchers, and other health professionals in South Carolina and other areas with significant rural populations on how travel burden may impact patients receiving care for lupus and provide an opportunity for the development of interventions aimed at assisting lupus patients with management of stressors related to travel burden.

Lupus nephritis, pregnancy and rituximab

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Enrique Dorado

2017-04-01

Full Text Available La nefritis lúpica (NL proliferativa es una de las complicaciones más graves del LES. La respuesta terapéutica con los esquemas clásicos no existe en el 20 al 70% de los casos, siendo la amplitud de dicho rango explicada por variaciones étnicas, falta de consenso en la definición de remisión, diferencias en los tiempos de tratamiento, seguimiento y en la clase de NL. En presencia de NL recidivante o refractaria los tratamientos y el nivel de evidencia sobre su eficacia son más limitados. Rituximab es un anticuerpo monoclonal quimérico (ratón-humano dirigido contra el antígeno CD 20 localizado en la superficie celular de los linfocitos B. Estos participan en la patogénesis del LES a partir de su maduración en células plasmáticas, producción de anticuerpos, secreción de citoquinas proinflamatorias, presentación de autoantígenos a las células T y en la activación de células T. La administración de rituximab genera un rápido y sostenido descenso de los linfocitos B CD 20+ circulantes y una reducción de los títulos de auto-anticuerpos. Se reportó una disminución significativa en los niveles de antiDNA a partir de la semana 14 y de los niveles de IgM, sin compromiso de IgG ni de IgA. Se detectó droga activa en sangre periférica luego de la semana 24 de la última infusión. La depleción de linfocitos B se puede mantener por 6 meses, su reconstitución es heterogénea y puede tardar más de un año. Esta linfopenia selectiva tendría un valor predictivo de respuesta terapéutica, la remisión clínica prolongada tendría asociación con repoblación incompleta de células B de memoria varios años luego del tratamiento. En estudios observacionales realizados en pacientes con NL refractaria se reportó respuesta terapéutica con rituximab entre 67-77 % luego de 6 a 12 meses de seguimiento. Sin embargo los resultados del estudio Lupus Nephritis Assesment with Rituximab (LUNAR, randomizado controlado, a doble ciego

Neuraminidase activity mediates IL-6 production by activated lupus-prone mesangial cells.

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Sundararaj, Kamala; Rodgers, Jessalyn I; Marimuthu, Subathra; Siskind, Leah J; Bruner, Evelyn; Nowling, Tamara K

2018-04-01

The development of nephritis is a leading cause of morbidity and mortality in lupus patients. Although the general pathophysiological progression of lupus nephritis is known, the molecular mediators and mechanisms are incompletely understood. Previously, we demonstrated that the glycosphingolipid (GSL) catabolic pathway is elevated in the kidneys of MRL/lpr lupus mice and human lupus patients with nephritis. Specifically, the activity of neuraminidase (NEU) and expression of Neu1, an enzyme in the GSL catabolic pathway is significantly increased. To better understand the role and mechanisms by which this pathway contributes to the progression of LN, we analyzed the expression and effects of NEU activity on the function of MRL/lpr lupus-prone mesangial cells (MCs). We demonstrate that NEU1 and NEU3 promote IL-6 production in MES13 MCs. Neu1 expression, NEU activity, and IL-6 production are significantly increased in stimulated primary MRL/lpr lupus-prone MCs, and blocking NEU activity inhibits IL-6 production. NEU1 and NEU3 expression overlaps IgG deposits in MCs in vitro and in renal sections from nephritic MRL/lpr mice. Together, our results suggest that NEU activity mediates IL-6 production in lupus-prone MCs possibly through an IgG-receptor complex signaling pathway.

Hydroxychloroquine in systemic lupus erythematosus (SLE).

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Ponticelli, C; Moroni, G

2017-03-01

Hydroxychloroquine (HCQ) is an alkalinizing lysosomatropic drug that accumulates in lysosomes where it inhibits some important functions by increasing the pH. HCQ has proved to be effective in a number of autoimmune diseases including systemic lupus erythematosus (SLE). Areas covered: In this review the mechanisms of action, the efficacy, and the safety of HCQ in the management of patients with SLE have been reviewed. HCQ may reduce the risk of flares, allow the reduction of the dosage of steroids, reduce organ damage, and prevent the thrombotic effects of anti-phospholipid antibodies. The drug is generally safe and may be prescribed to pregnant women. However, some cautions are needed to prevent retinopathy, a rare but serious complication of the prolonged use of HCQ. Expert opinion: HCQ may offer several advantages not only in patients with mild SLE but can also exert important beneficial effects in lupus patients with organ involvement and in pregnant women. The drug has a low cost and few side effects. These characteristics should encourage a larger use of HCQ, also in lupus patients with organ involvement.

Lupus and leprosy: beyond the coincidence.

Science.gov (United States)

Ribeiro, F M; Gomez, V E; Albuquerque, E M N; Klumb, E M; Shoenfeld, Y

2015-02-01

Systemic lupus erythematous (SLE) is an autoimmune disease that presents an increased susceptibility to infections which may trigger reactivation. Disease flares have been mostly associated with parvovirus B19, cytomegalovirus, EBV and Mycobacterium tuberculosis infections, but it is probable that many other agents may also induce innate and adaptive immune system stimulation including the production of autoantibodies as ANA, anti nDNA and anti-ß2-GPI mainly in lepromatous leprosy. Mycobacterium leprae not only may determine symptoms that mimic lupus flares, including autoantibodies production, but could also act as a trigger for lupus reactivation; however, its association is still not fully explored. As demonstrated for tuberculosis, it is quite possible that molecular mimicry may also be involved in the interface of these two diseases. Some studies reported shared epitopes among idiotypes derived from 8E7 and TH9 lepromatous antibodies and those obtained from SLE patients, and it could partially explain the triggering phenomenon of SLE caused by M. leprae. We report and discuss three Brazilian patients whose disease was inactive and presented disease flares concurrently with the diagnosis of leprosy.

Neurodevelopmental disorders in children born to mothers with systemic lupus erythematosus.

Science.gov (United States)

Vinet, É; Pineau, C A; Clarke, A E; Fombonne, É; Platt, R W; Bernatsky, S

2014-10-01

Children born to women with systemic lupus erythematosus seem to have a potentially increased risk of neurodevelopmental disorders compared to children born to healthy women. Recent experimental data suggest in utero exposure to maternal antibodies and cytokines as important risk factors for neurodevelopmental disorders. Interestingly, women with systemic lupus erythematosus display high levels of autoantibodies and cytokines, which have been shown, in animal models, to alter fetal brain development and induce behavioral anomalies in offspring. Furthermore, subjects with systemic lupus erythematosus and neurodevelopmental disorders share a common genetic predisposition, which could impair the fetal immune response to in utero immunologic insults. Moreover, systemic lupus erythematosus pregnancies are at increased risk of adverse obstetrical outcomes and medication exposures, which have been implicated as potential risk factors for neurodevelopmental disorders. In this article, we review the current state of knowledge on neurodevelopmental disorders and their potential determinants in systemic lupus erythematosus offspring. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Experimental anti-GBM disease as a tool for studying spontaneous lupus nephritis.

Science.gov (United States)

Fu, Yuyang; Du, Yong; Mohan, Chandra

2007-08-01

Lupus nephritis is an immune-mediated disease, where antibodies and T cells both play pathogenic roles. Since spontaneous lupus nephritis in mouse models takes 6-12 months to manifest, there is an urgent need for a mouse model that can be used to delineate the pathogenic processes that lead to immune nephritis, over a quicker time frame. We propose that the experimental anti-glomerular basement membrane (GBM) disease model might be a suitable tool for uncovering some of the molecular steps underlying lupus nephritis. This article reviews the current evidence that supports the use of the experimental anti-GBM nephritis model for studying spontaneous lupus nephritis. Importantly, out of about 25 different molecules that have been specifically examined in the experimental anti-GBM model and also spontaneous lupus nephritis, all influence both diseases concordantly, suggesting that the experimental model might be a useful tool for unraveling the molecular basis of spontaneous lupus nephritis. This has important clinical implications, both from the perspective of genetic susceptibility as well as clinical therapeutics.

Características clinicoepidemiológicas del lupus eritematoso sistémico. Hospital Manuel Uribe Ángel de Envigado

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Antonio Toro

2001-04-01

Full Text Available

El lupus eritematoso sistémico (LES es relativamente frecuente
e incapacitante, pero excepcionalmente mortal. Conscientes de lo anterior y de la falta de información epidemiológica al respecto en nuestra región, es de suma importancia analizar su comportamiento con el fin de obtener indicadores que brinden un conocimiento más adecuado de ella en nuestro medio, determinando cuáles son las formas de presentación clínica más frecuentes; así se podría disponer de información que guiara al clínico en un diagnóstico temprano y un tratamiento eficaz, con lo que se reduciría el riesgo de complicaciones y de letalidad prevenibles.

Juvenile systemic lupus erythematosus onset patterns in Vietnamese children

DEFF Research Database (Denmark)

Dung, Nguyen Thi Ngoc; Loan, Huynh Thoai; Nielsen, Susan

2013-01-01

to have systemic lupus erythematosus (f/m = 4/1) were referred to the Ho Chi Minh City Children's Hospital No.1 during a 12-month period in 2009. RESULTS: The mean age at diagnosis was 12.8 years (SD = 2.5). Thirty-seven (82%) fulfilled criteria for lupus nephritis (LN). At diagnosis, impressively high...... No. 1 during a16 month period from 2008-2009. These patients had a strikingly high prevalence of Coombs positive anaemia, a high prevalence of lupus nephritis, and very high SLEDAI and ECLAM scores at the time of diagnosis. While there may be referral biases, our Vietnamese SLE patients appear...

Study of audiovestibular dysfunction in children with systemic lupus erythematosus.

Science.gov (United States)

Gad, Ghada Ibrahim; Mohamed, Somaia Tawfik; Awwad, Khaled Salah; Mohamed, Rehab Fetoh

2013-09-01

Inner ear dysfunction in systemic lupus erythematosis patients has been reported but audiovestibular involvement is not well documented especially in pediatrics. This study was designed to evaluate silent audiovestibular dysfunction among SLE children. Case control study examined in allergy and immunology clinic; pediatrics hospital and audiovestibular clinic; Ain Shams University from January 2009 to December 2010. Thirty-five systemic lupus erythematosus children (diagnosed according to American College of Rheumatology); age group 8-16 years, were randomly selected. Five of them were excluded due to one or more exclusion criteria (previous otitis media, stroke, lupus cerebritis, meningitis or encephalitis, audiovestibular symptom). Ten of them refused enrollment or could not complete full battery. Seventeen females and three males, mean age 12.9 ± 2.6 years, completed the study. Control group included 20 normal subjects, age and sex matched. Full clinical assessment, basic audiological evaluation and vestibular testing (videonystagmography VNG and computerized dynamic posturography CDP) were conducted for children included in the study. Five systemic lupus erythematosus patients had sensorineural hearing loss strongly associated with +ve antiphospholipid antibody and two had conductive hearing loss. Two children in control group had conductive hearing loss (p=0.05). Abnormal VNG findings was significantly higher among systemic lupus erythematosus children (40%) compared to controls (0%) and associated with +ve antiphospholipid antibodies (χ(2)=10, p=0.002, Fisher exact test=0.003). Twenty-five percentage of systemic lupus erythematosus children had abnormal CDP findings reflecting impaired balance function associated with positive antiphospholipid antibodies showing significant statistical difference compared to controls (0% affection) (χ(2)=5.7, p=0.017, Fisher exact test=0.047). Silent audiovestibular dysfunction is prevalent among systemic lupus

Chilblain lupus erythematosus

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Mittal R

1994-01-01

Full Text Available Two cases of chilblain lupus erythematosus (CLE were seen in females aged 33 years and 18 years. Photosensitivity, chronicity and aggravation in winters were present in both cases. Histopathology revealed follicular keratosis, atrophy and extensive liquefaction of basal cells. Oral pradinisolone with chloroquine resulted in marked improvement in the skin lesions.

Association of STAT4 polymorphism with severe renal insufficiency in lupus nephritis.

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Karin Bolin

Full Text Available Lupus nephritis is a cause of significant morbidity in systemic lupus erythematosus (SLE and its genetic background has not been completely clarified. The aim of this investigation was to analyze single nucleotide polymorphisms (SNPs for association with lupus nephritis, its severe form proliferative nephritis and renal outcome, in two Swedish cohorts. Cohort I (n = 567 SLE cases, n = 512 controls was previously genotyped for 5676 SNPs and cohort II (n = 145 SLE cases, n = 619 controls was genotyped for SNPs in STAT4, IRF5, TNIP1 and BLK. Case-control and case-only association analyses for patients with lupus nephritis, proliferative nephritis and severe renal insufficiency were performed. In the case-control analysis of cohort I, four highly linked SNPs in STAT4 were associated with lupus nephritis with genome wide significance with p = 3.7 × 10(-9, OR 2.20 for the best SNP rs11889341. Strong signals of association between IRF5 and an HLA-DR3 SNP marker were also detected in the lupus nephritis case versus healthy control analysis (p <0.0001. An additional six genes showed an association with lupus nephritis with p <0.001 (PMS2, TNIP1, CARD11, ITGAM, BLK and IRAK1. In the case-only meta-analysis of the two cohorts, the STAT4 SNP rs7582694 was associated with severe renal insufficiency with p = 1.6 × 10(-3 and OR 2.22. We conclude that genetic variations in STAT4 predispose to lupus nephritis and a worse outcome with severe renal insufficiency.

¿Educadores o consumidores? discrepancia del yo, consumo y materialismo en estudiantes chilenos de pedagogía

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Marianela Denegri Coria

2014-05-01

Full Text Available El presente artículo tiene como propósito caracterizar las relaciones existentes entre la discrepancia del Yo, las actitudes hacia la compra y valores materialistas en estudiantes de Pedagogía considerando diferencias de género. Se aplicaron las escalas de Discrepancia del Yo, Actitudes hacia la Compra y Valores Materiales, en una muestra de 167 estudiantes chilenos de las carreras de Pedagogía en Historia de dos universidades del Sur de Chile. Los resultados obtenidos, evidencian correlaciones significativas entre las dimensiones de discrepancia del Yo físico, intelectual y económico, y las actitudes impulsivas y compulsivas hacia la compra; así como en las dimensiones de valores materiales vinculadas al éxito social y felicidad personal. En cuanto al género, se observa en las mujeres un perfil de ambivalencia actitudinal, donde coexiste la racionalidad con la compulsividad. A partir de la relevancia social del futuro ejercicio profesional de los estudiantes de pedagogía, los resultados se discuten considerando la importancia de la inclusión de la educación económica y financiera en la formación inicial de profesores, con un fuerte énfasis en la toma de conciencia acerca de sus actitudes y valores hacia el consumo. This paper aims to characterize the relationship between Self-discrepancy, attitudes toward buying and materialistic values ​​in pedagogy students considering gender differences. The Self-discrepancy scale and the Attitudes toward Purchase and Material Values scale were applied in a sample of 167 Chilean Pedagogy students majoring in History teaching in two universities in southern Chile. The results show significant correlations for Self-discrepancy between the physical, intellectual and economic dimensions and the impulsive and compulsive attitudes towards buying, as well as the dimensions of materialism linked to social success and personal happiness. Regarding gender, women display an ambivalent attitudinal

Early Prediction of Lupus Nephritis Using Advanced Proteomics

Science.gov (United States)

2012-06-01

Gupta IR . Evaluation of activity, chronicity and tubulointerstitial indices for childhood lupus nephritis. Pediatr Nephrol 2008;23:83–91. 34. Isenberg DA...University of Okla- homa Health Sciences Center, Oklahoma City: Drs. Michael Hen- drickson and James N. Jarvis (data collection); Tracy Fuelling...Duffy CM, Bernard C, Gupta IR : Evaluation of activity, chronicity and tubulointerstitial indices for childhood lupus nephritis. Pediatr Nephrol 2008

A case of "refractory" lupus erythematosus profundus responsive to rituximab [case report].

LENUS (Irish Health Repository)

McArdle, Adrian

2012-02-01

Lupus erythematosus profundus is a rare complication of systemic lupus erythematosus characterized by the presence of deep, tender subcutaneous nodules. A 22-year-old African-American female with extensive lupus profundus resistant to conventional therapies was treated with two infusions of the anti-CD20 monoclonal antibody, rituximab, at a dosage of 1,000 mg each. The patient demonstrated a remarkable clinical response as indicated by the disappearance of the nodules. B-cell depletion therapy with rituximab used alone or in combination with other therapies may be a viable option in patients with lupus profundus refractory to current therapies.

Tuberculosis and systemic lupus erythematosus: a case-control study in Mexico City.

Science.gov (United States)

Torres-González, Pedro; Romero-Díaz, Juanita; Cervera-Hernández, Miguel Enrique; Ocampo-Torres, Mario; Chaires-Garza, Luis Gerardo; Lastiri-González, Ernesto Alejandro; Atisha-Fregoso, Yemil; Bobadilla-Del-Valle, Miriam; Ponce-de-León, Alfredo; Sifuentes-Osornio, José

2018-04-20

To determine, among systemic lupus erythematosus patients, factors associated with active tuberculosis. We performed a case-control study, in a tertiary-care center in Mexico City. We defined cases as systemic lupus erythematosus patients with active tuberculosis and matched them 1:1 with systemic lupus erythematosus patients without tuberculosis (controls) by age, date of systemic lupus erythematosus diagnosis, and disease duration. We analyzed clinical variables, lupus disease activity (SLEDAI-2K), and accumulated damage (SLICC/ARC-DI). We performed a nonconditional logistic regression to determine factors associated with tuberculosis. We identified 72 tuberculosis cases among systemic lupus erythematosus patients, 58% were culture confirmed. Thirty-three percent (24/72) were pulmonary only, 47.2% (34/72) extrapulmonary only, and 19.4% both. After adjustment for age, gender, and socioeconomic status, SLEDAI-2K and SLICC/ARC-DI, a 1-year cumulative dose of prednisone ≥ 3 g (odds ratios (OR), 18.85; 95% confidence interval (95% CI), 6.91-51.45) was associated with tuberculosis, and the antimalarial treatment was protective (OR, 0.13; 95% CI, 0.04-0.36). Among systemic lupus erythematosus patients, cumulative dose of prednisone is associated with tuberculosis. Further research is required to elucidate the protective effect of antimalarial drugs for tuberculosis. Preventive strategies must be implemented in patients at risk.

Spontaneous ureteral rupture in a patient with systemic lupus erythematosus

International Nuclear Information System (INIS)

Benson, C.H.; Pennebaker, J.B.; Harisdangkul, V.; Songcharoen, S.

1983-01-01

A patient with known systemic lupus erythematosus had fever and symptoms of a lower urinary tract infection. Bone scintigraphy showed left ureteral perforation and necrosis with no demonstrable nephrolithiasis. It is speculated that this episode was due to lupus vasculitis

La ansiedad escénica en intérpretes musicales chilenos

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Mimí Marinovic

2006-06-01

Full Text Available La ansiedad escénica (AE es uno de los mayores problemas del ejercicio profesional de los intérpretes musicales. Encuestas realizadas en países desarrollados revelan cifras de prevalencia entre 24% -70% y citan casos severos, causantes del abandono de la carrera. Objetivos: detectar la prevalencia de la AE en músicos chilenos que desempeñan su profesión en los principales conjuntos de música de concierto y determinar algunos de los factores que, a su juicio, influyen en su aparición. Método: 249 intérpretes (122 instrumentistas, 26 directores y 101 cantantes respondieron un cuestionario autoaplicado, incluido en una investigación más amplia sobre los intérpretes de arte. Este instrumento fue complementado con 36 entrevistas abiertas (13 instrumentistas, 6 directores y 11 cantantes. Resultados: el 78% de los músicos estudiados admitió haber sufrido AE, más mujeres que varones. El 64% consideró que ella se relaciona principalmente con la tarea a ejecutar (preparación insuficiente, dificultad de la obra, mientras que el 32% lo atribuyó a factores personales (ser nervioso, temor al fracaso y sólo el 4% a factores situacionales. Hubo diferencias significativas por género, especialidad y edad. Las entrevistas permitieron profundizar acerca del alcance de estos resultados. Conclusiones: se constató una alta prevalencia de AE, la cual debiera ser abordada interdisciplinariamente por especialistas de la salud mental y la música en beneficio de la educación general, la formación especializada y el desarrollo profesional de los intérpretes musicalesPerformance anxiety (PA is one of the major problems that musicians face in their careers. Surveys carried out in developed countries show prevalence figures ranging 24% -70% and quote severe cases leading to abandonment of the profession. Objectives: detect the prevalence of PA in Chilean musicians working in the main groups of concert music and determine some of the factors that

La cultura nacional y su impacto en los negocios: el caso chileno

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Pedro Hidalgo Campos

2007-10-01

Full Text Available El objetivo de este artículo es analizar el impacto de la cultura nacional en los negocios. Uno de los investigadores más destacados en el análisis de la cultura nacional es Geert Hofstede (1980. Él identificó cuatro dimensiones de la cultura nacional: distancia de poder, aversión a la incertidumbre, individualismo y masculinidad. Fernández et al. (1997 midieron estas cuatro dimensiones en Chile, caracterizando a los chilenos en esas cuatro dimensiones. Revisando la evidencia empírica chilena, en este artículo se analizan los principales efectos que las dimensiones de Hofstede tienen en la administración, los recursos humanos y el marketing. Este artículo ofrece varios ejemplos de cómo las dimensiones culturales afectan las prácticas en las organizaciones y es un fuerte argumento para hacer consideraciones culturales en la planificación estratégica.

La cultura nacional y su impacto en los negocios: el caso chileno

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Pedro Hidalgo Campos

2007-01-01

Full Text Available El objetivo de este artículo es analizar el impacto de la cultura nacional en los negocios. Uno de los investigadores más destacados en el análisis de la cultura nacional es Geert Hofstede (1980. Él identificó cuatro dimensiones de la cultura nacional: distancia de poder, aversión a la incertidumbre, individualismo y masculinidad. Fernández et al. (1997 midieron estas cuatro dimensiones en Chile, caracterizando a los chilenos en esas cuatro dimensiones. Revisando la evidencia empírica chilena, en este artículo se analizan los principales efectos que las dimensiones de Hofstede tienen en la administración, los recursos humanos y el marketing. Este artículo ofrece varios ejemplos de cómo las dimensiones culturales afectan las prácticas en las organizaciones y es un fuerte argumento para hacer consideraciones culturales en la planificación estratégica.

Estructura social y modelos de «desarrollo»: el caso chileno

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Xabier ARRIZABALO MONTORO

2009-11-01

Full Text Available RESUMEN: El artículo analiza la relación entre la estructura social y el modelo de desarrollo, específicamente para el caso chileno, durante la dictadura de Pinochet (1973-1990. Las políticas económicas puestas en marcha por el régimen militar, y continuadas en buen grado por el gobierno de la Concertación, responden a un enfoque neoliberal que apoya el fortalecimiento del capitalismo, a expensas de más desempleo y condiciones de vida más precarias para los trabajadores y los pobres.ABSTRACT: The article analyzes the relationship among social structure and strategy of development, specifically for the Chilean case, during Pinochet's dictatorship (1973-1990. The Political Economies implemented by the military regime, and continued in many grades for the Concertation government, respond to a neoliberal approach which support the improvement of the capitalism but at the expense of more unemployment and more precarious conditions of life for the workers and the poor.

Refractory Angioedema in a Patient with Systemic Lupus Erythematosus

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Zahra Habibagahi

2015-07-01

Full Text Available Angioedema secondary to C1 inhibitor deficiency has been rarely reported to be associated with systemic lupus erythematosus. A genetic defect of C1 inhibitor produces hereditary angioedema, which is usually presented with cutaneous painless edema, but edema of the genital area, gastrointestinal and laryngeal tracts have also been reported. In lupus patients, angioedema may be the result of an acquired type of C1 inhibitor deficiency, most probably due to antibody formation directed against the C1 inhibitor molecule. Herein we report a new case of lupus nephritis that developed angioedema and a rapid course of disease progression with acute renal failure and alveolar hemorrhage without response to high dose steroid and plasmapheresis.

META-ESTEREOTIPOS SOBRE LOS INDÍGENAS MAPUCHES DE CHILE

OpenAIRE

José L. Saiz; María Eugenia Merino; Daniel Quilaqueo

2009-01-01

Se examinaron los meta-estereotipos sobre los mapuches chilenos, esto es, la percepción que miembros de este pueblo originario tienen sobre los estereotipos que los chilenos no indígenas les asignan. Se analizaron cinco aspectos de los meta-estereotipos: contenido (atributos), rótulos (etiquetas grupales), pre cisión (congruencia con estereotipos), uniformidad (consenso) y estructura (configuración de atributos y rótulos). Una muestra de 39 adultos mapuches de la Ciudad de Temuco (Chile) resp...

Bladder involvement in systemic lupus erythematosus

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Eric Roger Wroclawski

2009-12-01

Full Text Available Objective: To study bladder involvement in systemic lupus erythematosus patients through clinical and laboratorial evaluation, ultrasonography, radiological and endoscopic examination. Methods: Thirty-nine patients, either outpatients or inpatients at the Department of Rheumatology of Hospital das Clínicas da Faculdade de Medicina from Universidade de São Paulo were evaluated as to clinical and laboratorial data. All patients were submitted to ultrasonographic evaluation of the upper urinary tract, radiological and endoscopic examinations of the middle and lower urinary tracts. Rresults: Mean age of patients varied between 13 and 62 years (median = 29 years. Thirty-six were females and three were males. The disease varied from 6 months to 22 years (median three years and one month. Clinical and laboratory activity of the disease was present in 30 patients. Twenty-two patients had the diagnosis of lupus established for three years or more. Twenty-five patients were asymptomatic and all had received corticosteroids for treatment at least once. Twenty-three received antimalarial drugs; ten received cytostatics, and seven patients received non-steroid anti-inflammatory drugs. Upper urinary tract ultrasonography was normal in all cases but one with staghorn calculus associated with neurogenic bladder secondary to neurological involvement by the disease. Vesicoureteral reflux was observed in two cases. Other two patients had significant post-voiding residual urine, both with neurogenic bladder secondary to nervous system involvement by lupus. The average bladder maximum capacity in an awaken patient was 342 mL, and was decreased in 18.9% of cases. This subgroup of patients presented a greater frequency of urinary symptoms and greater use of cytostatic drugs (Z > Z5%. A pathognomonic cystoscopic pattern of bladder involvement in systemic lupus erythematosus could not be established. Cystoscopic aspects similar to those seen in the initial or minor

X-ray characteristics of the Lupus Loop and SN1006 supernova remnants

Energy Technology Data Exchange (ETDEWEB)

Toor, A [California Univ., Livermore (USA). Lawrence Livermore Lab.

1980-01-01

The spatial extent of the Lupus Loop and spectra for the Lupus Loop and SN1006 supernova remnants have been determined with a rocket-borne payload. The Lupus Loop is an extended source of soft X-rays (approx. 300' diam) that shows a correlation between its brightest X-ray and radio-emission regions. Its spectrum is characterized by a temperature of 350 eV. Thus, the Lupus Loop appears similar to Vela X and Cygnus Loop, although much weaker. Emission from SN1006 is spatially unresolved and exhibits a harder spectrum than that of the Lupus Loop. All spectral data (0.2 100 keV) from our observation and previous observations are satisfactorily fit with a power law (index = 2.15). This spectral dependence suggests the possibility that a rotating neutron star is the underlying source of the radiated energy although such an interpretation appears inconsistent with the remnant's morphology.

X-ray characteristics of the Lupus Loop and SN1006 supernova remnants

International Nuclear Information System (INIS)

Toor, A.

1980-01-01

The spatial extent of the Lupus Loop and spectra for the Lupus Loop and SN1006 supernova remnants have been determined with a rocket-borne payload. The Lupus Loop is an extended source of soft X-rays (approx. 300' diam) that shows a correlation between its brightest X-ray and radio-emission regions. Its spectrum is characterized by a temperature of 350 eV. Thus, the Lupus Loop appears similar to Vela X and Cygnus Loop, although much weaker. Emission from SN1006 is spatially unresolved and exhibits a harder spectrum than that of the Lupus Loop. All spectral data (0.2 100 keV) from our observation and previous observations are satisfactorily fit with a power law (index = 2.15). This spectral dependence suggests the possibility that a rotating neutron star is the underlying source of the radiated energy although such an interpretation appears inconsistent with the remnant's morphology. (orig.)

Redes sociales, acción colectiva y elecciones: los usos de Facebook por el movimiento estudiantil chileno durante la campaña electoral de 2013

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Lázaro M. Bacallao-Pino

2016-01-01

Full Text Available Los estudios recientes sobre las redes sociales digitales han analizado, por un lado, sus usos como parte de la acción colectiva y, por otro, sus usos durante las campañas electorales. Basado en el estudio del movimiento estudiantil chileno durante la campaña electoral de 2013 en ese país, el texto analiza los usos de Facebook por parte de tres federaciones estudiantiles que integran dicho movimiento. Los resultados indican que se priorizan las dimensiones informativa y organizativa en los usos de las redes sociales en ese contexto. Esta tendencia está mediada por las particularidades del movimiento —presencia de organizaciones estudiantiles tradicionales— y por la complejidad de la relación con la política institucional —en particular, la defensa de la autonomía frente a los riesgos de cooptación, acrecentados por el tránsito de exlíderes del movimiento a esta última—. De igual forma, también se confirma la tendencia a un mayor uso de estos espacios en momentos de mayor movilización social y se muestran las tensiones entre sus usos por parte de la acción colectiva organizada (federaciones estudiantiles y los sujetos individuales participantes en ella.

Thymus function in drug-induced lupus.

Science.gov (United States)

Rubin, R L; Salomon, D R; Guerrero, R S

2001-01-01

Autoimmunity develops when a lupus-inducing drug is introduced into the thymus of normal mice, but the relevance of this model to the human disorder is unclear in part because it is widely assumed that the thymus is non-functional in the adult. We compared thymus function in 10 patients with symptomatic procainamide-induced lupus to that in 13 asymptomatic patients who only developed drug-induced autoantibodies. T cell output from the thymus was quantified using a competitive polymerase chain reaction that detects T cell receptor DNA excision circles in peripheral blood lymphocytes. Despite the advanced age of the patient population under study, newly generated T cells were detected in all subjects. Although there was no overall quantitative difference between the symptomatic and asymptomatic patients, we found a positive correlation between the level of T cell receptor excision circles in peripheral lymphocytes and serum IgG anti-chromatin antibody activity in patients with drug-induced lupus. The association between autoantibodies and nascent peripheral T cells supports the requirement for T cells in autoantibody production. Our observations are consistent with findings in mice in which autoreactive T cells derived from drug-induced abnormalities in T cell development in the thymus.

Catatonia due to systemic lupus erythematosus

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Francisco de Assis Pinto Cabral Júnior Rabello

2014-07-01

Full Text Available Objectives Discuss neuropsychiatric aspects and differential diagnosis of catatonic syndrome secondary to systemic lupus erythematosus (SLE in a pediatric patient. Methods Single case report. Result A 13-year-old male, after two months diagnosed with SLE, started to present psychotic symptoms (behavioral changes, hallucinations and delusions that evolved into intense catatonia. During hospitalization, neuroimaging, biochemical and serological tests for differential diagnosis with metabolic encephalopathy, neurological tumors and neuroinfections, among other tests, were performed. The possibility of neuroleptic malignant syndrome, steroid-induced psychosis and catatonia was also evaluated. A complete reversal of catatonia was achieved after using benzodiazepines in high doses, associated with immunosuppressive therapy for lupus, which speaks in favor of catatonia secondary to autoimmune encephalitis due to lupus. Conclusion Although catatonia rarely is the initial clinical presentation of SLE, the delay in recognizing the syndrome can be risky, having a negative impact on prognosis. Benzodiazepines have an important role in the catatonia resolution, especially when associated with parallel specific organic base cause treatment. The use of neuroleptics should be avoided for the duration of the catatonic syndrome as it may cause clinical deterioration.

Research Progress on Systemic Lupus Erythematosus Complicated with Infection

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Zhang Weisan

2015-06-01

Full Text Available In recent years, in treatment standardization of systemic lupus erythematosus (SLE, infections and serious complications became the leading cause of death related to this disease, exceeding those of renal involvement and lupus encephalopathy. SLE coinfection is mainly related to defects in humoral immunity and cellular immunity, SLE disease activity, and doses of hormone and immune inhibitors.

Massive intracranial calcifications in a patient with systemic lupus erythematosus

International Nuclear Information System (INIS)

Gasparetto, Emerson L.; Carvalho Neto, Arnolfo de; Ono, Sergio E.

2004-01-01

Central nervous system involvement is frequently reported in patients with systemic lupus erythematosus. Computed tomography and magnetic resonance imaging studies usually show brain atrophy, cerebral infarction and/or intracranial bleeding. Extensive intracranial calcification in patients with systemic lupus erythematosus is rare. We report a case of a patient with systemic lupus erythematosus who presented with seizures and massive basal ganglia calcification and mild calcifications in the frontal lobes, seen on the brain computed tomography scan. Magnetic resonance imaging showed hyperintensity on FLAIR images and hypointense signals on T2 * gradient echo images in the basal ganglia. (author)

Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes?

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Giuliana Guggino

2012-01-01

Full Text Available In this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR and decoy receptors (DcR involved in the generation of systemic lupus erythematosus (SLE and lupus-like syndromes in human and mouse models. To date, these molecules were described in several autoimmune disorders such as rheumatoid arthritis, antiphospholipids syndrome, bowel inflammation, and SLE. Here, we summarize the findings of recent investigations on TLR and DcR and their role in the immunopathogenesis of the SLE.

Gastrointestinal system involvement in systemic lupus erythematosus.

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Li, Z; Xu, D; Wang, Z; Wang, Y; Zhang, S; Li, M; Zeng, X

2017-10-01

Systemic lupus erythematosus (SLE) is a multisystem disorder which can affect the gastrointestinal (GI) system. Although GI symptoms can manifest in 50% of patients with SLE, these have barely been reviewed due to difficulty in identifying different causes. This study aims to clarify clinical characteristics, diagnosis and treatment of the four major SLE-related GI system complications: protein-losing enteropathy (PLE), intestinal pseudo-obstruction (IPO), hepatic involvement and pancreatitis. It is a systematic review using MEDLINE and EMBASE databases and the major search terms were SLE, PLE, IPO, hepatitis and pancreatitis. A total of 125 articles were chosen for our study. SLE-related PLE was characterized by edema and hypoalbuminemia, with Technetium 99m labeled human albumin scintigraphy ( 99m Tc HAS) and alpha-1-antitrypsin fecal clearance test commonly used as diagnostic test. The most common site of protein leakage was the small intestine and the least common site was the stomach. More than half of SLE-related IPO patients had ureterohydronephrosis, and sometimes they manifested as interstitial cystitis and hepatobiliary dilatation. Lupus hepatitis and SLE accompanied by autoimmune hepatitis (SLE-AIH overlap) shared similar clinical manifestations but had different autoantibodies and histopathological features, and positive anti-ribosome P antibody highly indicated the diagnosis of lupus hepatitis. Lupus pancreatitis was usually accompanied by high SLE activity with a relatively high mortality rate. Early diagnosis and timely intervention were crucial, and administration of corticosteroids and immunosuppressants was effective for most of the patients.

Evaluation of cerebral perfusion in patients with neuropsychiatric systemic lupus erythematosus using 123I-IMP SPECT

International Nuclear Information System (INIS)

Yoshida, Atsuko; Shishido, Fumio; Kato, Kazuo; Watanabe, Hiroshi; Seino, Osamu

2007-01-01

In the course of systemic lupus erythematosus (SLE), central nervous system (CNS) complications occur at a high frequency. An accurate diagnosis of CNS lupus, differentiated from secondary CNS involvement, is difficult. CNS lupus is indicative of advancing primary disease and is treated by steroid pulse therapy or increased dosage of steroids. In contrast, if symptoms are caused by secondary CNS complications, it is possible to observe or treat these complications using symptomatic therapy. We examined whether quantitative cerebral blood flow (CBF) measured using cerebral perfusion single photon emission computed tomography (SPECT) can be used to differentiate CNS lupus from secondary CNS involvement. We divided 18 SLE patients with CNS symptoms into a CNS lupus group and a non-CNS lupus group, and then compared the mean cerebral blood flow (mCBF) of each group of patients. SPECT was performed with N-isopropyl-p-[ 123 I] iodoamphetamine (IMP), with quantitation carried out by table look-up and autoradiographic methods. The mCBF of both groups was decreased; however, the mCBF of patients with CNS lupus was significantly lower than that of non-CNS lupus patients. Quantitative CBF may provide a useful tool to distinguish CNS lupus from non-CNS lupus. (author)

Systemic lupus erythematosus in a male patient

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Sibarani, H.; Zubir, Z.

2018-03-01

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder with a broad spectrum of clinical presentations. Female to male ratio is approximately 9:1.A 20 years old male was admitted to HAM Hospital 3 months ago with chief complaint pain in both knees joint. After anamneses, physical examination and laboratory test the patient was diagnosed with systemic lupus erythematosus. The patient tested positive for ANA and anti-ds-DNA antibody test. The patient was with giving non-biologic DMARDS @myfortic 360mg, methylprednisolone, chloroquine and other symptomatic drugs.

Lupus eritematoso sistémico en ratones MRL lpr/lpm y knockouts del receptor de quimioquina CCR2

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Camarasa Lillo, Natalia

2009-01-01

INTRODUCCIÓN El lupus eritematoso sistémico es una enfermedad autoinmune cuya principal manifestación y debut de la enfermedad es la glomerulonefritis mediada por complejos inmunes. Los ratones MRL/MpJ-Fas lpr/J (MRL/lpr) llevan una mutación en el gen Fas de la apoptosis que da lugar a una proliferación de linfocitos autoreactivos y son considerados un modelo de ratón que reproduce muy bien la enfermedad lúpica en el humano, con linfadenopatía asociada a proliferación aberrante de células T,...

The involvement of galectin-3 in skin injury in systemic lupus erythematosus patients.

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Shi, Z; Meng, Z; Han, Y; Cao, C; Tan, G; Wang, L

2018-04-01

Objective Our previous research suggested that anti-galectin-3 antibody was highly associated with the development of lupus skin lesions in systemic lupus erythematosus (SLE). In this study we aimed to investigate the involvement of galectin-3 in SLE skin damage. Methods The study consisted of 49 patients with SLE, 16 with dermatomyositis and 11 with systemic scleroderma and 20 healthy controls. Galectin-3 was examined by ELISA and immunohistochemical staining in serum and skin, respectively. Results Serum galectin-3 was significantly higher in patients with SLE than in those with dermatomyositis ( P  0.05). As for subtypes of skin lesions in SLE, galectin-3 expression was lower in chronic cutaneous lupus erythematosus than in acute cutaneous lupus erythematosus ( P = 0.0439). Conclusion Serum galectin-3 is unlikely to play a role in the pathogenesis of lupus skin damage, but can be a potential biomarker for the measurement of SLE disease activity. Galectin-3 is greatly reduced in patients with lupus lesions compared with healthy controls, which may contribute to the recruitment of inflammatory cells in the skin.

Aymaras, peruanos y chilenos en los Andes ariqueños: Resistencia y conflicto frente a la chilenización del norte de Chile

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Alberto Díaz Araya

2006-05-01

Full Text Available Este artículo reflexiona desde un punto de vista de la antropología histórica las reacciones y articulaciones que generaron las comunidades Aymaras del área de Arica entre los años 1901 y 1926, periodo reconocido como “chilenización”, ante la presencia del Estado chileno, asumiendo posturas identitarias sociopolíticas en un ambiente de conflicto nacional.

Systemic lupus erythematosus diagnostics in the ‘omics’ era

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Arriens, Cristina; Mohan, Chandra

2014-01-01

Systemic lupus erythematosus is a complex autoimmune disease affecting multiple organ systems. Currently, diagnosis relies upon meeting at least four out of eleven criteria outlined by the ACR. The scientific community actively pursues discovery of novel diagnostics in the hope of better identifying susceptible individuals in early stages of disease. Comprehensive studies have been conducted at multiple biological levels including: DNA (or genomics), mRNA (or transcriptomics), protein (or proteomics) and metabolites (or metabolomics). The ‘omics’ platforms allow us to re-examine systemic lupus erythematosus at a greater degree of molecular resolution. More importantly, one is hopeful that these ‘omics’ platforms may yield newer biomarkers for systemic lupus erythematosus that can help clinicians track the disease course with greater sensitivity and specificity. PMID:24860621

Cardiac tamponade as an initial manifestation of systemic lupus erythematosus.

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Carrion, Diego M; Carrion, Andres F

2012-06-12

Clinical manifestations of pericardial disease may precede other signs and symptoms associated with systemic lupus erythematosus. Although pericardial effusion is one of the most common cardiac problems in patients with systemic lupus erythematosus, haemodynamically significant effusions manifesting as cardiac tamponade are rare and require prompt diagnosis and treatment.

Invasive fungal infections in Colombian patients with systemic lupus erythematosus.

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Santamaría-Alza, Y; Sánchez-Bautista, J; Fajardo-Rivero, J F; Figueroa, C L

2018-06-01

Introduction Systemic lupus erythematosus is an autoimmune disease with multi-organ involvement. Complications, such as invasive fungal infections usually occur in patients with a greater severity of the disease. Objective The objective of this study was to determine the prevalence and risk variables associated with invasive fungal infections in a Colombian systemic lupus erythematosus population. Materials and methods A cross-sectional, retrospective study that evaluated patients with systemic lupus erythematosus for six years. The primary outcome was invasive fungal infection. Descriptive, group comparison and bivariate analysis was performed using Stata 12.0 software. Results Two hundred patients were included in this study; 84.5% of the patients were women and the median age was 36 years; 68% of the subjects had haematological complications; 53.3% had nephropathy; 45% had pneumopathy and 28% had pericardial impairment; 7.5% of patients had invasive fungal infections and the most frequently isolated fungus was Candida albicans. Pericardial disease, cyclophosphamide use, high disease activity, elevated ESR, C3 hypocomplementemia, anaemia and lymphopenia had a significant association with invasive fungal infection ( P lupus erythematosus, which was higher than that reported in other latitudes. In this population the increase in disease activity, the presence of pericardial impairment and laboratory alterations (anaemia, lymphopenia, increased ESR and C3 hypocomplementemia) are associated with a greater possibility of invasive fungal infections. Regarding the use of drugs, unlike other studies, in the Colombian population an association was found only with the previous administration of cyclophosphamide. In addition, patients with invasive fungal infections and systemic lupus erythematosus had a higher prevalence of mortality and hospital readmission compared with patients with systemic lupus erythematosus without invasive fungal infection.

Brain MRI findings of neuropsychiatric lupus

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Kim, Jang-Wook; Kwon, Bae Ju; Lee, Seung-Ro; Hahm, Chang-Kok; Moon, Won Jin; Jeon, Eui Yong; Bae, Sang-Chul [Hanyang Univ. School of Medicine, Seoul (Korea, Republic of)

2000-12-01

To evaluate the brain MRI findings in patients with neuropsychiatric lupus. In 26 patients (M:F = 2:24 ; aged 9-48 years) in whom the presence of systemic lupus erythematosus was clinically or pathologically proven and in whom neuropsychiatric lupus was also clinically diagnosed, the findings of brain MRI were retrospectively evaluated. MR images were analyzed with regard to the distribution, location, size and number of lesions due to cerebral ischemia or infarction, the presence of cerebral atrophy, and the extent and degree of brain parenchymal and intravascular enhancement. The most common MRI findings were lesions due to cerebral ischemia or infarction occurring in 18 patients (69%), and located within deep periventricular white matter (n=10), subcortical white matter (n=8), the cerebral cortex (n=7), basal ganglia (n=7), or brain stem or cerebellum (n=2). The lesions were single (n=3) or multiple (n=15), and in 17 patients were less than 1cm in diameter in regions other than the cerebral cortex. In six of these patients, lesions of 1-4cm in diameter in this region were combined, and one occurred in the cerebral cortex only. Cerebral atrophy was seen in 16 patients (62%), in ten of whom there was no past history of treatment with steroids for more than six months. In 15 patients (58%), contrast-enhanced MR image revealed diffuse enhancement of the basal ganglia or intravascular enhancement. In no case were MRI findings normal. The primary mainfestations of neuropsychiatric lupus are multifocal ischemia or infarctions in the cerebral cortex, and subcortical and deep white matter, and the cerebral atrophy. Contrast-enhanced MR images also demonstrated diffuse enhancement of the basal ganglia and intravascular enhancement, both thought to be related to the congestion due to the stagnation of cerebral blood flow.

Brain MRI findings of neuropsychiatric lupus

International Nuclear Information System (INIS)

Kim, Jang-Wook; Kwon, Bae Ju; Lee, Seung-Ro; Hahm, Chang-Kok; Moon, Won Jin; Jeon, Eui Yong; Bae, Sang-Chul

2000-01-01

To evaluate the brain MRI findings in patients with neuropsychiatric lupus. In 26 patients (M:F = 2:24 ; aged 9-48 years) in whom the presence of systemic lupus erythematosus was clinically or pathologically proven and in whom neuropsychiatric lupus was also clinically diagnosed, the findings of brain MRI were retrospectively evaluated. MR images were analyzed with regard to the distribution, location, size and number of lesions due to cerebral ischemia or infarction, the presence of cerebral atrophy, and the extent and degree of brain parenchymal and intravascular enhancement. The most common MRI findings were lesions due to cerebral ischemia or infarction occurring in 18 patients (69%), and located within deep periventricular white matter (n=10), subcortical white matter (n=8), the cerebral cortex (n=7), basal ganglia (n=7), or brain stem or cerebellum (n=2). The lesions were single (n=3) or multiple (n=15), and in 17 patients were less than 1cm in diameter in regions other than the cerebral cortex. In six of these patients, lesions of 1-4cm in diameter in this region were combined, and one occurred in the cerebral cortex only. Cerebral atrophy was seen in 16 patients (62%), in ten of whom there was no past history of treatment with steroids for more than six months. In 15 patients (58%), contrast-enhanced MR image revealed diffuse enhancement of the basal ganglia or intravascular enhancement. In no case were MRI findings normal. The primary mainfestations of neuropsychiatric lupus are multifocal ischemia or infarctions in the cerebral cortex, and subcortical and deep white matter, and the cerebral atrophy. Contrast-enhanced MR images also demonstrated diffuse enhancement of the basal ganglia and intravascular enhancement, both thought to be related to the congestion due to the stagnation of cerebral blood flow

Renal cell apoptosis in human lupus nephritis: a histological study

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Faurschou, M; Penkowa, Milena; Andersen, C B

2009-01-01

Nuclear autoantigens from apoptotic cells are believed to drive the immunological response in systemic lupus erythematosus (SLE). Conflicting data exist as to the possible renal origin of apoptotic cells in SLE patients with nephritis. We assessed the level of renal cell apoptosis in kidney...... biopsies from 35 patients with lupus nephritis by means of terminal deoxynucleotidyl-transferase (TdT)-mediated deoxyuridine triphosphate (dUTP)-digoxigenin nick end labeling (TUNEL). Five samples of normal kidney tissue served as control specimens. We did not observe apoptotic glomerular cells in any...... cells constitute a quantitatively important source of auto-antibody-inducing nuclear auto-antigens in human lupus nephritis....

Acute macular neuroretinopathy associated with systemic lupus erythematosus.

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Lee, D H; Lee, S C; Kim, M

2016-04-01

Acute macular neuroretinopathy (AMN) is a rare disorder that presents with abrupt visual change with wedge-shaped or flower-like lesions pointing towards the fovea. Ischemic insults to the retinal capillary plexus may be important for development of this disease. While many case reports have been published on AMN, none have described AMN in association with systemic lupus erythematosus (SLE). Here, we report a case of AMN associated with newly-diagnosed SLE. We speculate that in patients with lupus flares, immune complex-mediated vascular injury and microvascular thrombosis may disrupt the deep retinal capillary network, causing ischemic damages to the outer retina and leading to the development of AMN. AMN can develop in patients with lupus flares, and must be considered as an SLE-associated ophthalmologic complication. To the best of our knowledge, this is the first case report of AMN associated with SLE. © The Author(s) 2015.

Pigmented villonodular synovitis of the hip in systemic lupus erythematosus: a case report

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Anders Hans-Joachim

2011-09-01

Full Text Available Abstract Introduction Pigmented villonodular synovitis is a rare disease of unknown etiology mostly affecting the knee and foot. Until now an association with autoimmune diseases has not been reported. Case presentation The diagnosis of systemic lupus erythematosus was made in a 15-year-old Caucasian girl based on otherwise unexplained fatigue, arthralgia, tenosynovitis, leukopenia, low platelets and the presence of antinuclear and deoxyribonucleic antibodies. At the age of 20 a renal biopsy revealed lupus nephritis class IV and she went into complete remission with mycophenolate mofetil and steroids. She was kept on mycophenolate mofetil for maintenance therapy. At the age of 24 she experienced a flare-up of lupus nephritis with nephrotic syndrome and new onset of pain in her right hip. Magnetic resonance imaging, arthroscopy and subtotal synovectomy identified pigmented villonodular synovitis as the underlying diagnosis. Although her systemic lupus erythematosus went into remission with another course of steroids and higher doses of mycophenolate mofetil, the pigmented villonodular synovitis persisted and she had to undergo open synovectomy to control her symptoms. Conclusion Systemic lupus erythematosus is associated with many different musculoskeletal manifestations including synovitis and arthritis. Pigmented villonodular synovitis has not previously been reported in association with systemic lupus erythematosus, but as its etiology is still unknown, the present case raises the question about a causal relationship between systemic lupus erythematosus and pigmented villonodular synovitis.

Lupus risk variants in the PXK locus alter B-cell receptor internalization

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Samuel E. Vaughn

2015-01-01

Full Text Available Genome wide association studies have identified variants in PXK that confer risk for humoral autoimmune diseases, including systemic lupus erythematosus (SLE or lupus, rheumatoid arthritis and more recently systemic sclerosis. While PXK is involved in trafficking of epidermal growth factor Receptor (EGFR in COS-7 cells, mechanisms linking PXK to lupus pathophysiology have remained undefined. In an effort to uncover the mechanism at this locus that increases lupus-risk, we undertook a fine-mapping analysis in a large multi-ancestral study of lupus patients and controls. We define a large (257kb common haplotype that confers lupus risk detected only in European ancestral populations and spans the promoter through the 3’ UTR of PXK. The strongest association was found at rs6445972 with P < 4.62 x 10-10, OR 0.81 (0.75 – 0.86. Using stepwise logistic regression analysis, we demonstrate that one signal drives the genetic association in the region. Bayesian analysis confirms our results, identifying a 95% credible set consisting of 172 variants spanning 200kb.Functionally, we found that PXK operates on the B-cell antigen receptor (BCR; we confirmed that PXK influenced the rate of BCR internalization. Furthermore, we demonstrate that individuals carrying the risk haplotype exhibited a decreased rate of BCR internalization, a process known to impact B cell survival and cell fate. Taken together, these data define a new candidate mechanism for the genetic association of variants around PXK with lupus risk and highlight the regulation of intracellular trafficking as a genetically regulated pathway mediating human autoimmunity.

EL PRIMER APORTE DE LOS OBISPOS CHILENOS A LA CODIFICACIÓN DEL DERECHO CANÓNICO DE 1917: LOS POSTULATA EPISCOPORUM ACERCA DEL MATRIMONIO

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Carlos Salinas Araneda

2008-12-01

Full Text Available La redacción del primer Código de Derecho Canónico que tuvo la Iglesia latina fue ordenado por el papa san Pío X, en 1904. La tarea codificadora, empero, no fue obra de un grupo cerrado de expertos, sino que tuvo en cuenta el parecer del episcopado, el que fue consultado en dos momentos diferentes; en ambos casos fueron requeridos los obispos chilenos. En este trabajo se estudia, a partir de la documentación guardada en el Archivo Secreto Vaticano, el aporte de los obispos chilenos en la primera consulta, realizada en 1904, en lo referido al matrimonio.The drafting of the first Código de Derecho Canónico of the Latin Church was established by Pope Pío X in 1904. The codifying task, however, was not the result of a closed group of experts. It considered the opinión of bishops around the world who were consulted in two different moments. In both cases, Chilean bishops were requested to provide their opinions. This work, which is based on documents from the Vatican Secret Archives, studies the contribution of Chilean bishops to the marriage discussion in the first round of consultation of 1904.

Ultraviolet-A1 irradiation therapy for systemic lupus erythematosus.

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McGrath, H

2017-10-01

Systemic lupus erythematosus (lupus, SLE) is a chronic autoimmune disease characterized by the production of autoantibodies, which bind to antigens and are deposited within tissues to fix complement, resulting in widespread systemic inflammation. The studies presented herein are consistent with hyperpolarized, adenosine triphosphate (ATP)-deficient mitochondria being central to the disease process. These hyperpolarized mitochondria resist the depolarization required for activation-induced apoptosis. The mitochondrial ATP deficits add to this resistance to apoptosis and also reduce the macrophage energy that is needed to clear apoptotic bodies. In both cases, necrosis, the alternative pathway of cell death, results. Intracellular constituents spill into the blood and tissues, eliciting inflammatory responses directed at their removal. What results is "autoimmunity." Ultraviolet (UV)-A1 photons have the capacity to remediate this aberrancy. Exogenous exposure to low-dose, full-body, UV-A1 radiation generates singlet oxygen. Singlet oxygen has two major palliative actions in patients with lupus and the UV-A1 photons themselves have several more. Singlet oxygen depolarizes the hyperpolarized mitochondrion, triggering non-ATP-dependent apoptosis that deters necrosis. Next, singlet oxygen activates the gene encoding heme oxygenase (HO-1), a major governor of systemic homeostasis. HO-1 catalyzes the degradation of the oxidant heme into biliverdin (converted to bilirubin), Fe, and carbon monoxide (CO), the first three of these exerting powerful antioxidant effects, and in conjunction with a fourth, CO, protecting against injury to the coronary arteries, the central nervous system, and the lungs. The UV-A1 photons themselves directly attenuate disease in lupus by reducing B cell activity, preventing the suppression of cell-mediated immunity, slowing an epigenetic progression toward SLE, and ameliorating discoid and subacute cutaneous lupus. Finally, a combination of these

Ultraviolet-A1 irradiation therapy for systemic lupus erythematosus

Science.gov (United States)

2017-01-01

Systemic lupus erythematosus (lupus, SLE) is a chronic autoimmune disease characterized by the production of autoantibodies, which bind to antigens and are deposited within tissues to fix complement, resulting in widespread systemic inflammation. The studies presented herein are consistent with hyperpolarized, adenosine triphosphate (ATP)-deficient mitochondria being central to the disease process. These hyperpolarized mitochondria resist the depolarization required for activation-induced apoptosis. The mitochondrial ATP deficits add to this resistance to apoptosis and also reduce the macrophage energy that is needed to clear apoptotic bodies. In both cases, necrosis, the alternative pathway of cell death, results. Intracellular constituents spill into the blood and tissues, eliciting inflammatory responses directed at their removal. What results is “autoimmunity.” Ultraviolet (UV)-A1 photons have the capacity to remediate this aberrancy. Exogenous exposure to low-dose, full-body, UV-A1 radiation generates singlet oxygen. Singlet oxygen has two major palliative actions in patients with lupus and the UV-A1 photons themselves have several more. Singlet oxygen depolarizes the hyperpolarized mitochondrion, triggering non-ATP-dependent apoptosis that deters necrosis. Next, singlet oxygen activates the gene encoding heme oxygenase (HO-1), a major governor of systemic homeostasis. HO-1 catalyzes the degradation of the oxidant heme into biliverdin (converted to bilirubin), Fe, and carbon monoxide (CO), the first three of these exerting powerful antioxidant effects, and in conjunction with a fourth, CO, protecting against injury to the coronary arteries, the central nervous system, and the lungs. The UV-A1 photons themselves directly attenuate disease in lupus by reducing B cell activity, preventing the suppression of cell-mediated immunity, slowing an epigenetic progression toward SLE, and ameliorating discoid and subacute cutaneous lupus. Finally, a combination of

Facilitadores institucionales y sociales para la gobernanza local de los riesgos medioambientales. Análisis empírico con municipios chilenos

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Patricio Valdivieso

Full Text Available Resumen El contexto latinoamericano de exposición a riesgos medioambientales demanda un mayor entendimiento de los factores institucionales que tienen impacto en la gestión medioambiental local. Con el apoyo de métodos mixtos de investigación, este estudio examina hipótesis sobre relaciones entre factores políticos, institucionales, sociales y la gestión medioambiental municipal, en el contexto empírico de municipalidades chilenas. Los resultados sugieren que la combinación de factores políticos, arreglos y capacidades institucionales, y relaciones con la sociedad explican diferentes comportamientos municipales.

Pregnancy and renal outcomes in lupus nephritis: an update and guide to management.

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Bramham, K; Soh, M C; Nelson-Piercy, C

2012-10-01

Systemic lupus erythematosis (SLE) commonly affects women of child bearing-age, and advances in treatment have resulted in an increasing number of women with renal involvement becoming pregnant. Knowledge of the relationship of the condition with respect to fertility and pregnancy is important for all clinicians involved in the care of women with lupus nephritis because they have complicated pregnancies. Presentation of lupus nephritis can range from mild asymptomatic proteinuria to rapidly progressive renal failure and may occur before, during, or after pregnancy. The timing of diagnosis may influence pregnancy outcome. Pregnancy may also affect the course of lupus nephritis. All pregnancies in women with lupus nephritis should be planned, preferably after more than six-months of quiescent disease. Predictors of poor obstetric outcome include active disease at conception or early pregnancy, baseline poor renal function with Creatinine >100 μmol/L, proteinuria >0.5 g/24 hours, presence of concurrent antiphospholipid syndrome and hypertension. In this review the most recent studies of pregnancies in women with lupus nephritis are discussed and a practical approach to managing women prepregnancy, during pregnancy and post-partum is described.

Chronic hydroxychloroquine improves endothelial dysfunction and protects kidney in a mouse model of systemic lupus erythematosus.

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Gómez-Guzmán, Manuel; Jiménez, Rosario; Romero, Miguel; Sánchez, Manuel; Zarzuelo, María José; Gómez-Morales, Mercedes; O'Valle, Francisco; López-Farré, Antonio José; Algieri, Francesca; Gálvez, Julio; Pérez-Vizcaino, Francisco; Sabio, José Mario; Duarte, Juan

2014-08-01

Hydroxychloroquine has been shown to be efficacious in the treatment of autoimmune diseases, including systemic lupus erythematosus. Hydroxychloroquine-treated lupus patients showed a lower incidence of thromboembolic disease. Endothelial dysfunction, the earliest indicator of the development of cardiovascular disease, is present in lupus. Whether hydroxychloroquine improves endothelial function in lupus is not clear. The aim of this study was to analyze the effects of hydroxychloroquine on hypertension, endothelial dysfunction, and renal injury in a female mouse model of lupus. NZBWF1 (lupus) and NZW/LacJ (control) mice were treated with hydroxychloroquine 10 mg/kg per day by oral gavage, or with tempol and apocynin in the drinking water, for 5 weeks. Hydroxychloroquine treatment did not alter lupus disease activity (assessed by plasma double-stranded DNA autoantibodies) but prevented hypertension, cardiac and renal hypertrophy, proteinuria, and renal injury in lupus mice. Aortae from lupus mice showed reduced endothelium-dependent vasodilator responses to acetylcholine and enhanced contraction to phenylephrine, which were normalized by hydroxychloroquine or antioxidant treatments. No differences among all experimental groups were found in both the relaxant responses to acetylcholine and the contractile responses to phenylephrine in rings incubated with the nitric oxide synthase inhibitor N(G)-nitro-l-arginine methyl ester. Vascular reactive oxygen species content and mRNA levels of nicotinamide adenine dinucleotide phosphate oxidase subunits NOX-1 and p47(phox) were increased in lupus mice and reduced by hydroxychloroquine or antioxidants. Chronic hydroxychloroquine treatment reduced hypertension, endothelial dysfunction, and organ damage in severe lupus mice, despite the persistent elevation of anti-double-stranded DNA, suggesting the involvement of new additional mechanisms to improve cardiovascular complications. © 2014 American Heart Association, Inc.

Identification of unique microRNA signature associated with lupus nephritis.

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Jeannie L Te

2010-05-01

Full Text Available MicroRNAs (miRNA have emerged as an important new class of modulators of gene expression. In this study we investigated miRNA that are differentially expressed in lupus nephritis. Microarray technology was used to investigate differentially expressed miRNA in peripheral blood mononuclear cells (PBMCs and Epstein-Barr Virus (EBV-transformed cell lines obtained from lupus nephritis affected patients and unaffected controls. TaqMan-based stem-loop real-time polymerase chain reaction was used for validation. Microarray analysis of miRNA expressed in both African American (AA and European American (EA derived lupus nephritis samples revealed 29 and 50 differentially expressed miRNA, respectively, of 850 tested. There were 18 miRNA that were differentially expressed in both racial groups. When samples from both racial groups and different specimen types were considered, there were 5 primary miRNA that were differentially expressed. We have identified 5 miRNA; hsa-miR-371-5P, hsa-miR-423-5P, hsa-miR-638, hsa-miR-1224-3P and hsa-miR-663 that were differentially expressed in lupus nephritis across different racial groups and all specimen types tested. Hsa-miR-371-5P, hsa-miR-1224-3P and hsa-miR-423-5P, are reported here for the first time to be associated with lupus nephritis. Our work establishes EBV-transformed B cell lines as a useful model for the discovery of miRNA as biomarkers for SLE. Based on these findings, we postulate that these differentially expressed miRNA may be potential novel biomarkers for SLE as well as help elucidate pathogenic mechanisms of lupus nephritis. The investigation of miRNA profiles in SLE may lead to the discovery and development of novel methods to diagnosis, treat and prevent SLE.

Current and emerging treatment options in the management of lupus

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Jordan, Natasha; D’Cruz, David

2016-01-01

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with variable clinical manifestations. While the clearest guidelines for the treatment of SLE exist in the context of lupus nephritis, patients with other lupus manifestations such as neuropsychiatric, hematologic, musculoskeletal, and severe cutaneous lupus frequently require immunosuppression and/or biologic therapy. Conventional immunosuppressive agents such as mycophenolate mofetil, azathioprine, and cyclophosphamide are widely used in the management of SLE with current more rationalized treatment regimens optimizing the use of these agents while minimizing potential toxicity. The advent of biologic therapies has advanced the treatment of SLE particularly in patients with refractory disease. The CD20 monoclonal antibody rituximab and the anti-BLyS agent belimumab are now widely in use in clinical practice. Several other biologic agents are in ongoing clinical trials. While immunosuppressive and biologic agents are the foundation of inflammatory disease control in SLE, the importance of managing comorbidities such as cardiovascular risk factors, bone health, and minimizing susceptibility to infection should not be neglected. PMID:27529058

Radiologic findings in late-onset systemic lupus erythematosus

International Nuclear Information System (INIS)

Braunstein, E.M.; Weissman, B.N.; Sosman, J.L.; Schur, P.H.

1983-01-01

Systemic lupus erythematosus in the elderly has a different clinical and serologic course from that in young patients. Radiographic findings in patients in whom the diagnosis was made after age 50 were compared with findings in younger patients to see if the radiologic patterns are also different. The only significant radiographic difference between the two groups was that the older group had a greater incidence of soft-tissue swelling of the hands and wrists (p < 0.001). There was no significant difference in osteopenia, erosion, soft-tissue calcification, alignment abnormalities, or intrathoracic findings. Of 24 patients over age 50, two developed lymphoma and another developed multiple myeloma. The data agree with clinical observations that there is a higher incidence of arthritis in late-onset lupus, but clinical findings of increased incidence of pleuropericardial disease are not confirmed radiographically. The coincidence of hematologic malignancy with late-onset lupus in this series is noteworthy

Association of Sweet's Syndrome and Systemic Lupus Erythematosus

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J. L. Barton

2011-01-01

Full Text Available Sweet's syndrome is an acute febrile neutrophilic dermatosis which usually presents as an idiopathic disorder but can also be drug induced, associated with hematopoetic malignancies and myelodysplastic disorders, and more, infrequently, observed in autoimmune disorders. Sweet's syndrome has been reported in three cases of neonatal lupus, three cases of hydralazine-induced lupus in adults, and in nine pediatric and adult systemic lupus erythematosus (SLE patients. We describe three additional adult cases of Sweet's associated with SLE and provide a focused review on nondrug-induced, nonneonatal SLE and Sweet's. In two of three new cases, as in the majority of prior cases, the skin rash of Sweet's paralleled underlying SLE disease activity. The pathogenesis of Sweet's remains elusive, but evidence suggests that cytokine dysregulation may be central to the clinical and pathological changes in this condition, as well as in SLE. Further research is needed to define the exact relationship between the two conditions.

Cutaneous lupus erythematosus, morphea profunda and psoriasis: A case report.

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García-Arpa, Mónica; Flores-Terry, Miguel A; Ramos-Rodríguez, Claudia; Franco-Muñoz, Monserrat; González-Ruiz, Lucía; Ramírez-Huaranga, Marco Aurelio

2018-04-03

Psoriasis is a common inflammatory dermatosis that may be associated with a number of diseases. Recent studies provide evidence that there is a greater frequency of autoimmune diseases, but association with autoimmune connective tissue diseases is uncommon. The coexistence of psoriasis and lupus erythematosus is rare. Besides, the occurrence of morphea has rarely been reported in patients with lupus or psoriasis. We report a woman with cutaneous lupus and morphea profunda associated with psoriasis, with an excellent response to methotrexate, and review the literature. Copyright © 2018 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.

Lymphoma risk in systemic lupus

DEFF Research Database (Denmark)

Bernatsky, Sasha; Ramsey-Goldman, Rosalind; Joseph, Lawrence

2014-01-01

OBJECTIVE: To examine disease activity versus treatment as lymphoma risk factors in systemic lupus erythematosus (SLE). METHODS: We performed case-cohort analyses within a multisite SLE cohort. Cancers were ascertained by regional registry linkages. Adjusted HRs for lymphoma were generated...

Systemic lupus erythematosus in Denmark

DEFF Research Database (Denmark)

Voss, A; Green, A; Junker, P

1998-01-01

A population based cohort of patients with systemic lupus erythematosus (SLE) was recruited from a for epidemiological purposes representative Danish region. Patients were ascertained from 4 different sources with a high degree of completeness as estimated by using capture-recapture analysis...

Validez predictiva del instrumento de evaluación de riesgos y recursos para la intervención FER-R, en adolescentes chilenos infractores de ley / Predictive Validity at the Instrument Risk and Resources (FER-R for Intervention Assessment with Young Offenders: Preliminary Study

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Paula Alarcón

2012-12-01

Full Text Available Se estudió la validez predictiva del instrumento Ficha de Evaluación de Riesgos y Recursos (FER-R para adolescentes infractores de ley, en un lapso de dos años (2009-2011. La FER-R consta de 60 ítems y permite el registro de 10 dominios, riesgos criminogénicos, recursos y el registro de un índice de escalada delictiva. La muestra estuvo conformada por 101 adolescentes varones, entre 14 y 19 años de edad, judicializados y deriva- dos a programas de intervención en medio libre. Los principales resultados muestran que el índice general de riesgo medido por la FER-R, presenta un 68.3 % de aciertos, con un área bajo la curva ROC = 0.73, indicando una magnitud predictiva fuerte de la escala total para predecir reincidencia en los adolescentes infractores chilenos.

High risk of ischemic heart disease in patients with lupus nephritis

DEFF Research Database (Denmark)

Faurschou, Mikkel; Mellemkjaer, Lene; Starklint, Henrik

2011-01-01

To investigate the occurrence of ischemic heart disease (IHD) in a cohort of 104 Danish patients with biopsy-proven lupus nephritis (LN).......To investigate the occurrence of ischemic heart disease (IHD) in a cohort of 104 Danish patients with biopsy-proven lupus nephritis (LN)....

Risk of infective endocarditis in patients with systemic lupus erythematosus in Taiwan: a nationwide population-based study.

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Chang, Y S; Chang, C C; Chen, Y H; Chen, W S; Chen, J H

2017-10-01

Objectives Patients with systemic lupus erythematosus are considered vulnerable to infective endocarditis and prophylactic antibiotics are recommended before an invasive dental procedure. However, the evidence is insufficient. This nationwide population-based study evaluated the risk and related factors of infective endocarditis in systemic lupus erythematosus. Methods We identified 12,102 systemic lupus erythematosus patients from the National Health Insurance research-oriented database, and compared the incidence rate of infective endocarditis with that among 48,408 non-systemic lupus erythematosus controls. A Cox multivariable proportional hazards model was employed to evaluate the risk of infective endocarditis in the systemic lupus erythematosus cohort. Results After a mean follow-up of more than six years, the systemic lupus erythematosus cohort had a significantly higher incidence rate of infective endocarditis (42.58 vs 4.32 per 100,000 person-years, incidence rate ratio = 9.86, p endocarditis in systemic lupus erythematosus patients. Conclusions A higher risk of infective endocarditis was observed in systemic lupus erythematosus patients. Risk factors for infective endocarditis in the systemic lupus erythematosus cohort included heart disease, chronic kidney disease, steroid pulse therapy within 30 days, and a recent invasive dental procedure within 30 days.

Factores psicosociales del presentismo en trabajadores del Sistema de Salud chileno

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Aldo Vera-Calzaretta

2015-01-01

Full Text Available Este estudio analizó los factores psicosociales que explicaban el presentismo o deterioro laboral autopercibido asociado a trabajar enfermo. La muestra fue de 676 trabajadores del sistema de salud chileno (84% de mujeres, M = 35.9 anos, en su mayoría enfermeras y técnicos paramédicos. Se aplicó un cuestiona- ˜ rio sociodemográfico, el Job Content Questionnaire, el Effort-Reward Imbalance, el Health Performance Questionnaire y una escala de interferencia del trabajo en la vida familiar. La regresión lineal explicó el 21% de la varianza del deterioro laboral percibido. Este último se asoció a asistir a trabajar enfermo. Los resultados sugieren que el deterioro del desempeno y asistir a trabajar enfermo son dos aspectos del ˜ mismo proceso. El ausentismo por razones de salud, la interferencia del trabajo en la vida familiar y la sintomatología emocional predijeron el deterioro laboral. Éste último se asoció negativamente a trabajar en turnos, controlando edad y salario. Los resultados sugieren que el presentismo es explicado por factores del contexto de trabajo y el conflicto trabajo-familia.

Unique Protein Signature of Circulating Microparticles in Systemic Lupus Erythematosus

DEFF Research Database (Denmark)

Østergaard, Ole; Nielsen, Christoffer; Iversen, Line V

2013-01-01

To characterize the unique qualities of proteins associated with circulating subcellular material in systemic lupus erythematosus (SLE) patients compared with healthy controls and patients with other chronic autoimmune diseases.......To characterize the unique qualities of proteins associated with circulating subcellular material in systemic lupus erythematosus (SLE) patients compared with healthy controls and patients with other chronic autoimmune diseases....

Periosteal reaction in systemic lupus erythematosus

International Nuclear Information System (INIS)

Glickstein, M.; Neustadter, L.; Dalinka, M.; Kricun, M.

1986-01-01

The authors report three patients with systemic lupus erythematosus and periosteal reaction. Two of the three cases had systemic vasculitis and the third had local ischemia with ischemic necrosis. (orig.)

A case of systemic lupus erythematosus presenting as bilateral avascular necrosis of femur.

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Adikari, Madura; Gunawardane, Aloka; Illangantilaka, Sachithra; Atukorale, Himantha; Rubasinghe, Jeevanie

2016-08-05

Avascular necrosis occur as a result of diverse etiology. Chronic inflammatory conditions such as systemic lupus erythematosus considered as a recognize cause. Many cases were reported in systemic lupus erythematosus after treating with corticosteroids. We report a case of a corticosteroid naïve patient presented as bilateral avascular necrosis of femoral head and later progressed to a case of systemic lupus erythematosus. A 26 year old lady presented with right sided hip pain and diagnosed as avascular necrosis of the femoral head. After 6 months she presented a similar pain in left hip, which revealed avascular necrosis of left femoral head as well. A probable cause for her clinical presentation could not be found after extensive clinical and laboratory evaluation. Patient reported high erythrocyte sedimentation rate persistently, and over the next few years progressed as a case of systemic lupus erythematosus. Above case illustrated avascular necrosis could be an early musculoskeletal manifestation of systemic lupus erythematosus even in the absence of corticosteroid administration.

Epístolas Sacrílegas. Las declaraciones públicas de líderes evangélicos chilenos ante el gobierno militar de Pinochet (1974 y 1986

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Miguel Ángel Mansilla

2015-12-01

Full Text Available Resumen La relación establecida entre el mundo evangélico y la dictadura militar chilena es uno de los episodios más significativos de la historia política y religiosa reciente en Chile. Si bien este fenómeno ha sido investigado tanto por las ciencias sociales como por la teología, sus posturas han tendido a desarrollarse de manera desvinculada, ofreciendo una imagen parcelada de la problemática. El presente artículo intenta ser un aporte en este ámbito específico, para lo cual se ha fijado un objetivo concreto: analizar los elementos ideológicos y políticos distintivos de las declaraciones públicas realizadas por el mundo evangélico ante el gobierno militar, vinculándolas con los contextos ideológicos en los cuales se emitieron estas declaraciones. Para ello, metodológicamente se han analizado dos declaraciones fundamentales realizadas por los líderes y pastores evangélicos ante el régimen militar chileno (fuentes primarias, lo cual permitirá complejizar la imagen que se posee sobre la relación entre el mundo evangélico y la dictadura militar chilena.

Lupus induced by medicaments

International Nuclear Information System (INIS)

Canas D, Carlos Alberto; Perafan B, Pablo Eduardo

2001-01-01

We describe a 55 years old female patient who consulted by fever syndrome, artralgias and the presence of high tittles positives antinuclear antibodies. She had arterial hypertension in treatment with captopril. We suspected the clinical diagnoses of drug-induced lupus; the withdraw of captopril was associated with the remission of the clinical and laboratory manifestations

Extensive hypertrophic lupus erythematosus: Atypical presentation

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Tarun Narang

2012-01-01

Full Text Available Lupus erythematosus (LE is a disease with a wide spectrum of cutaneous and systemic manifestations. Clinical features of patients with LE show a great variation, and for this reason it is difficult to develop a unifying concept of this disease. Our objective is to present a case of hypertrophic LE with atypical morphology and extensive involvement, who responded favorably to isotretinoin. Diagnosis of hypertrophic lupus erythematosus (HLE was confirmed by characteristic histopathological findings. Combination therapy with isotretinoin and hydroxychloroquine resulted in flattening and repression of previously refractory skin lesions. Sometimes, HLE lesions may present a diagnostic and therapeutic dilemma. In long standing lesions, squamous cell carcinoma may arise. Therefore, HLE requires adequate therapy with clinical and histopathological follow up.

Integrative medicine for managing the symptoms of lupus nephritis

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Choi, Tae-Young; Jun, Ji Hee; Lee, Myeong Soo

2018-01-01

Abstract Background: Integrative medicine is claimed to improve symptoms of lupus nephritis. No systematic reviews have been performed for the application of integrative medicine for lupus nephritis on patients with systemic lupus erythematosus (SLE). Thus, this review will aim to evaluate the current evidence on the efficacy of integrative medicine for the management of lupus nephritis in patients with SLE. Methods and analyses: The following electronic databases will be searched for studies published from their dates of inception February 2018: Medline, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL), as well as 6 Korean medical databases (Korea Med, the Oriental Medicine Advanced Search Integrated System [OASIS], DBpia, the Korean Medical Database [KM base], the Research Information Service System [RISS], and the Korean Studies Information Services System [KISS]), and 1 Chinese medical database (the China National Knowledge Infrastructure [CNKI]). Study selection, data extraction, and assessment will be performed independently by 2 researchers. The risk of bias (ROB) will be assessed using the Cochrane ROB tool. Dissemination: This systematic review will be published in a peer-reviewed journal and disseminated both electronically and in print. The review will be updated to inform and guide healthcare practice and policy. Trial registration number: PROSPERO 2018 CRD42018085205 PMID:29595669

Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice.

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Menke, Julia; Hsu, Mei-Yu; Byrne, Katelyn T; Lucas, Julie A; Rabacal, Whitney A; Croker, Byron P; Zong, Xiao-Hua; Stanley, E Richard; Kelley, Vicki R

2008-11-15

Sunlight (UVB) triggers cutaneous lupus erythematosus (CLE) and systemic lupus through an unknown mechanism. We tested the hypothesis that UVB triggers CLE through a CSF-1-dependent, macrophage (Mø)-mediated mechanism in MRL-Fas(lpr) mice. By constructing mutant MRL-Fas(lpr) strains expressing varying levels of CSF-1 (high, intermediate, none), and use of an ex vivo gene transfer to deliver CSF-1 intradermally, we determined that CSF-1 induces CLE in lupus-susceptible MRL-Fas(lpr) mice, but not in lupus-resistant BALB/c mice. UVB incites an increase in Møs, apoptosis in the skin, and CLE in MRL-Fas(lpr), but not in CSF-1-deficient MRL-Fas(lpr) mice. Furthermore, UVB did not induce CLE in BALB/c mice. Probing further, UVB stimulates CSF-1 expression by keratinocytes leading to recruitment and activation of Møs that, in turn, release mediators, which induce apoptosis in keratinocytes. Thus, sunlight triggers a CSF-1-dependent, Mø-mediated destructive inflammation in the skin leading to CLE in lupus-susceptible MRL-Fas(lpr) but not lupus-resistant BALB/c mice. Taken together, CSF-1 is envisioned as the match and lupus susceptibility as the tinder leading to CLE.

Systemisk lupus erythematosus og graviditet

DEFF Research Database (Denmark)

Schreiber, Karen; Lykke, Jacob Alexander; Nielsen, Henriette Svarre

2016-01-01

Systemic lupus erythematosus (SLE) is a complex autoimmune disease which most often affects women of childbearing age. Pregnancy is therefore an important issue for the patient and the responsible physician. Pregnancy outcomes in women with SLE has improved significantly over the latest decades...

Incidence of cervical human papillomavirus infection in systemic lupus erythematosus women.

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Mendoza-Pinto, C; García-Carrasco, M; Vallejo-Ruiz, V; Méndez-Martínez, S; Taboada-Cole, A; Etchegaray-Morales, I; Muñóz-Guarneros, M; Reyes-Leyva, J; López-Colombo, A

2017-08-01

Objectives Our objective was to study the incidence, persistence and clearance of human papillomavirus infection in systemic lupus erythematosus women and assess risk factors for persistence of human papillomavirus infection. Methods We carried out a prospective, observational cohort study of 127 systemic lupus erythematosus women. Patients were evaluated at baseline and at three years. Traditional and systemic lupus erythematosus women-related disease risk factors were collected. Gynaecological evaluations and cervical cytology screening were made. Human papillomavirus detection and genotyping were made by polymerase chain reaction and linear array. Results The cumulative prevalence of human papillomavirus infection increased from 22.8% at baseline to 33.8% at three years; p = lupus erythematosus women, the cumulative prevalence of human papillomavirus infection, including high risk-human papillomavirus and multiple human papillomavirus infections, may increase over time. Most persistent infections were low risk-human papillomavirus. The number of lifetime sexual partners and the cumulative cyclophosphamide dose were independently associated with incident human papillomavirus infection.

Clearing the complexity: immune complexes and their treatment in lupus nephritis

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Catherine Toong

2011-01-01

Full Text Available Catherine Toong1, Stephen Adelstein1, Tri Giang Phan21Department of Clinical Immunology, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, NSW, Australia; 2Immunology Program, Garvan Institute of Medical Research and St. Vincent’s Clinical School, University of New South Wales, Darlinghurst, NSW, AustraliaAbstract: Systemic lupus erythematosus (SLE is a classic antibody-mediated systemic autoimmune disease characterised by the development of autoantibodies to ubiquitous self-antigens (such as antinuclear antibodies and antidouble-stranded DNA antibodies and widespread deposition of immune complexes in affected tissues. Deposition of immune complexes in the kidney results in glomerular damage and occurs in all forms of lupus nephritis. The development of nephritis carries a poor prognosis and high risk of developing end-stage renal failure despite recent therapeutic advances. Here we review the role of DNA-anti-DNA immune complexes in the pathogenesis of lupus nephritis and possible new treatment strategies aimed at their control.Keywords: immune complex, systemic lupus erythematosus, nephritis, therapy

Lupus community panel proposals for optimising clinical trials: 2018

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Merrill, Joan T; Manzi, Susan; Aranow, Cynthia; Askenase, Anca; Bruce, Ian; Chakravarty, Eliza; Chong, Ben; Costenbader, Karen; Dall’Era, Maria; Ginzler, Ellen; Hanrahan, Leslie; Kalunian, Ken; Merola, Joseph; Raymond, Sandra; Rovin, Brad; Saxena, Amit; Werth, Victoria P

2018-01-01

Formidable impediments stand in the way of treatment development for lupus. These include the unwieldy size of current trials, international competition for scarce patients, complex outcome measures and a poor understanding of these outcomes in the world at large. The heterogeneity of the disease itself coupled to superimposition of variegated background polypharmacy has created enough immunological noise to virtually ensure the failure of lupus treatment trials, leaving an understandable suspicion that at least some of the results in testing failed drugs over the years may not have been negative, but merely uninterpretable. The authors have consulted with many clinical trial investigators, biopharmaceutical developers and stakeholders from government and voluntary sectors. This paper examines the available evidence that supports workable trial designs and proposes approaches to improve the odds of completing interpretable treatment development programs for lupus. PMID:29657738

Efficacy of Intravenous Cyclophosphamide Pulse Therapy for P-Glycoprotein-expressing B Cell-associated Active True Renal Lupus Vasculitis in Lupus Nephritis

Science.gov (United States)

Kawabe, Akio; Tsujimura, Shizuyo; Saito, Kazuyoshi; Tanaka, Yoshiya

2017-01-01

True renal lupus vasculitis (TRLV), a vascular lesion usually associated with proliferative lupus nephritis (LN), is resistant to conventional treatments. The expression of P-glycoprotein (P-gp) on activated lymphocytes causes drug resistance. We herein report a patient with TRLV, minimal change LN, overexpression of P-gp on peripheral B cells, and accumulation of P-gp+ B cells at the site of TRLV. High-dose corticosteroids combined with intravenous cyclophosphamide pulse therapy resulted in clinical remission and the long-term normal renal function. PMID:28626187

Prognostic implications of active discoid lupus erythematosus and malar rash at the time of diagnosis of systemic lupus erythematosus: Results from a prospective cohort study.

Science.gov (United States)

Drucker, A M; Su, J; Mussani, F; Siddha, S K; Gladman, D D; Urowitz, M B

2016-04-01

Cutaneous lupus erythematosus (CLE) may have prognostic implications for systemic lupus erythematosus (SLE). We aimed to determine the impact of discoid lupus erythematosus (DLE) and malar rash on SLE disease activity. Data were analyzed from the Toronto Lupus Clinic prospective cohort study. We compared SLE patients with active DLE or malar rash at SLE diagnosis to SLE patients who never developed CLE. Outcomes were assessed at one and five years, including Adjusted Mean Systemic Lupus Erythematosus Disease Activity Index 2000 (AMS). A total of 524 SLE patients (284 without CLE, 65 with DLE, and 175 with malar rash) were included. Mean AMS scores in patients without CLE at one and five years were 5.96 ± 5.06 and 4.00 ± 3.52, which did not differ significantly from scores at one (6.93 ± 5.31, p = 0.17) and five years (4.29 ± 2.62, p = 0.63) in the DLE group. In patients with malar rash, AMS scores at one (8.30 ± 6.80, p < 0.001) and five years (5.23 ± 3.06, p = 0.004) were higher than controls without CLE. Malar rash may be a marker of more severe systemic disease over time, while DLE has no significant impact on general SLE disease activity. © The Author(s) 2015.

I Am Newly Diagnosed with Lupus

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... Finding the Right Doctor Flares Lupus and the Workplace Mental Health and Wellbeing Self-Advocacy Signs and Symptoms Treatment Options all resource types Articles Downloadable PDFs Q & A List Blog Personal Stories ...

Mucormycosis in systemic lupus erythematosus.

Science.gov (United States)

Mok, Chi Chiu; Que, Tak Lun; Tsui, Edmund Yik Kong; Lam, Wing Yin

2003-10-01

To describe a case of mucormycosis in systemic lupus erythematosus (SLE) and to review other patients reported in the English literature. A Medline search for articles about mucormycosis in SLE published between 1970 and 2002 was performed by using the key words "lupus," "mucormycosis," "zygomycosis," "Mucorales," "Rhizopus," and "Mucor." Cases were pooled for analysis, and the mycology, diagnosis, treatment, and outcome of mucormycosis in SLE was reviewed. Eight cases of mucormycosis in SLE were identified (female:male = 7:1). The mean age at the time of infection was 31.8 +/- 7.6 years and the mean duration of SLE was 6.3 +/- 3.9 years. All except 1 patient had active lupus and all were receiving high-dose corticosteroids. Concomitant cytotoxic agents were used in 4 patients. Additional predisposing factors for opportunistic infection included hypocomplementemia, nephrotic syndrome, uremia, leukopenia, and diabetes mellitus. The disseminated form of mucormycosis was the most common presentation and the diagnosis often was made only at autopsy (63%). For cases with positive culture results, Rhizopus was the causative species. In 4 patients, manifestations of the fungal infection mimicked those of active SLE. The overall mortality of mucormycosis was very high (88%) and, in most cases, was probably a function of delayed diagnosis and treatment. The cutaneous form appeared to have the best prognosis with combined medical and surgical treatment. Mucormycosis is a rare but usually fatal fungal infection in SLE. Judicious use of immunosuppressive agents, a high index of suspicion, early diagnosis, and combination treatment with amphotericin B and surgical debridement may improve the prognosis of this serious infection.

Defective B cell response to T-dependent immunization in lupus-prone mice

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Niu, Haitao; Sobel, Eric S.; Morel, Laurence

2009-01-01

Lupus anti-nuclear Abs show the characteristics of Ag-driven T cell-dependent (TD) humoral responses. If autoAgs elicit the same response as exogenous Ags, lupus should enhance humoral responses to immunization. Blunted responses to various immunizations have, however, been reported in a significant portion of lupus patients. In this study, we show that lupus-prone B6.Sle1.Sle2.Sle3 (B6.TC) mice produce significantly less Ab in response to TD immunization than congenic controls, while producing significantly more total Ig. This blunted Ab response to TD Ag could be reconstituted with B6.TC B and CD4+ T cells. Multiple defects were found in the B6.TC response to NP-KLH as compared to total Ig, including a smaller percentage of B cells participating to the NP-response, a reduced entry into germinal centers, and highly defective production of NP-specific long-lived plasma cells in the bone marrow. B6.TC plasma cells expressed reduced levels of FcγRIIb, which suggests that reduced apoptosis in resident plasma cells prevents the establishment of newly-formed NP-specific plasma cells in bone marrow niches. Overall, these results show that lupus-prone mice responded differently to auto- and exogenous antigens and suggest that low FcγRIIb, hypergammaglobulinemia and high autoantibody production would be predictive of a poor response to immunization in lupus patients. PMID:18924209

Lupus erythematosus/lichen planus overlap syndrome: successful treatment with acitretin.

Science.gov (United States)

Lospinoso, D J; Fernelius, C; Edhegard, K D; Finger, D R; Arora, N S

2013-07-01

Lupus erythematosus/lichen planus overlap syndrome is a rare disorder combining the clinical, histological and immunopathological features of both lupus erythematosus (LE) and lichen planus (LP). Cutaneous lesions mostly affect the distal arms, legs, face and trunk. Palmoplantar involvement is felt to be characteristic of this condition. Plaques are often painful, centrally atrophic, bluish-red to hypopigmented in color, large, and scaly. On biopsy of clinically ambiguous lesions, histopathological features of one or both processes can be found, obscuring the diagnosis and complicating prognosis and treatment. Thus, direct immunofluorescence has become an essential tool in helping to diagnose this condition. In this report we describe the unique clinical and immunohistopathological manifestations of lupus erythematosus/lichen planus overlap syndrome along with a successful response to treatment with acitretin.

SLE disease patterns in a Danish population-based lupus cohort: an 8-year prospective study

DEFF Research Database (Denmark)

Laustrup, H; Voss, A; Green, A

2009-01-01

In 1995 all systemic lupus erythematosus (SLE) patients in the county of Funen were retrieved from four separate and independent sources as part of an 8-year prospective study to determine the pattern of disease activity and damage accumulation in a community based lupus cohort of predominantly...... Scandinavian ancestry. Incident cases were subsequently identified by surveillance of these sources. Established and new cases underwent annual, structured interviews, clinical examination and blood sampling. The Systemic Lupus Erythematosus Diseases Activity Index SLEDAI and Systemic Lupus International...

Ultraviolet light and cutaneous lupus

NARCIS (Netherlands)

Bijl, Marc; Kallenberg, Cees G. M.

2006-01-01

Exposure to ultraviolet (UV) light is one of the major factors known to trigger cutaneous disease activity in (systemic) lupus erythematosus patients. UV light, UVB in particular, is a potent inducer of apoptosis. Currently, disturbed clearance of apoptotic cells is one of the concepts explaining

Achados capilaroscópicos no lúpus eritematoso Capillaroscopy findings in lupus erythematosus

Directory of Open Access Journals (Sweden)

Anamaria da Silva Facina

2006-12-01

Full Text Available FUNDAMENTOS: A capilaroscopia é método não invasivo e reprodutível capaz de analisar diretamente os capilares na região periungueal, auxiliando no diagnóstico diferencial das doenças do tecido conectivo. OBJETIVOS: Estudar, por meio da capilaroscopia periungueal, pacientes com lúpus eritematoso cutâneo crônico, lúpus eritematoso sistêmico e grupo controle. MÉTODOS: Foram analisados 70 pacientes pela capilaroscopia periungueal, sendo 37 com lúpus eritematoso cutâneo crônico e 33 com forma sistêmica, comparados a 32 indivíduos sadios. RESULTADOS: A presença de capilares ectasiados (p=0,027; p=0,001, enovelados (p=0,001; p=0,007 e em saca-rolhas (p=0,011;p=0,005, além de hemorragias capilares (p=0,004; p=0,001 foram parâmetros capazes de discriminar os dois grupos de pacientes do grupo controle. A variável capilar enovelado demonstrou ser preditiva para o diagnóstico de lúpus eritematoso sistêmico (OR=8,308. As variáveis independentes capilares ectasiados (OR=12,164 e hemorragias capilares (OR=5,652 foram preditoras para lúpus eritematoso cutâneo crônico. CONCLUSÃO: A capilaroscopia é útil na prática clínica, pois pacientes com alterações capilaroscópicas específicas parecem ter maior probabilidade de desenvolver lúpus eritematoso. As variáveis preditoras independentes para lúpus eritematoso sistêmico foram capilares enovelados e para lúpus eritematoso cutâneo crônico foram capilares ectasiados e hemorragias capilares.BACKGROUND: Capillaroscopy is an useful diagnostic tool that is non-invasive, reproducible, able to assess the capillaries in the periungal region and that assists in the differential diagnosis of connective tissue diseases. OBJETIVES: The aim of the study was to distinguish chronic cutaneous lupus erythematosus and systemic lupus erythematosus from controls assessed by nailfold capillaroscopy. METHODS: Seventy patients with lupus erythematosus (37 with chronic cutaneous lupus erythematosus

THE LUPUS TRANSIT SURVEY FOR HOT JUPITERS: RESULTS AND LESSONS

International Nuclear Information System (INIS)

Bayliss, Daniel D. R.; Sackett, Penny D.; Weldrake, David T. F.; Tingley, Brandon W.; Lewis, Karen M.

2009-01-01

We present the results of a deep, wide-field transit survey targeting 'Hot Jupiter' planets in the Lupus region of the Galactic plane conducted over 53 nights concentrated in two epochs separated by a year. Using the Australian National University 40-inch telescope at Siding Spring Observatory (SSO), the survey covered a 0.66 deg 2 region close to the Galactic plane (b = 11 0 ) and monitored a total of 110,372 stars (15.0 ≤ V ≤ 22.0). Using difference imaging photometry, 16,134 light curves with a photometric precision of σ < 0.025 mag were obtained. These light curves were searched for transits, and four candidates were detected that displayed low-amplitude variability consistent with a transiting giant planet. Further investigations, including spectral typing and radial velocity measurements for some candidates, revealed that of the four, one is a true planetary companion (Lupus-TR-3), two are blended systems (Lupus-TR-1 and 4), and one is a binary (Lupus-TR-2). The results of this successful survey are instructive for optimizing the observational strategy and follow-up procedure for deep searches for transiting planets, including an upcoming survey using the SkyMapper telescope at SSO.

Systemic lupus erythematosus in Spanish males: a study of the Spanish Rheumatology Society Lupus Registry (RELESSER) cohort.

Science.gov (United States)

Riveros Frutos, A; Casas, I; Rúa-Figueroa, I; López-Longo, F J; Calvo-Alén, J; Galindo, M; Fernández-Nebro, A; Pego-Reigosa, J M; Olivé Marqués, A

2017-06-01

Objective The objective of this study was to describe the demographic, clinical, and immunological manifestations of systemic lupus erythematosus (SLE) in male patients. Methods A cross-sectional, multicenter study was carried out of 3651 patients (353 men, 9.7%, and 3298 women, 90.2%) diagnosed with SLE, included in the Spanish Rheumatology Society SLE Registry (RELESSER). Results Mean ages (18-92 years) of symptom onset were 37 (SD 17) years (men) and 32 (SD 14) years (women). Male/female ratio was 1/9. Age of onset of symptoms and age at diagnosis were higher in men than in women ( p lupus nephritis was more common in men, being present in 155 (44.8%) of males versus 933 (29%) of females ( p  50 years had a higher mortality (odds ratios 3.6 and 2.1, respectively). Furthermore, SLE patients who developed pulmonary hemorrhage, pulmonary hypertension, psychiatric involvement, complement deficiency, and hemophagocytic syndrome also had higher mortality, regardless of gender. Conclusion Patients with SLE over the age of 50 years have an increased risk of mortality. In Caucasians, age at diagnosis and symptom onset is higher in men than in women. The diagnostic delay is shorter in men. Male SLE patients present more cardiovascular comorbidities, and also more serositis, adenopathies, splenomegaly, renal involvement, convulsion, thrombosis, and lupus anticoagulant positivity than women.

Control of lupus nephritis by changes of gut microbiota.

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Mu, Qinghui; Zhang, Husen; Liao, Xiaofeng; Lin, Kaisen; Liu, Hualan; Edwards, Michael R; Ahmed, S Ansar; Yuan, Ruoxi; Li, Liwu; Cecere, Thomas E; Branson, David B; Kirby, Jay L; Goswami, Poorna; Leeth, Caroline M; Read, Kaitlin A; Oestreich, Kenneth J; Vieson, Miranda D; Reilly, Christopher M; Luo, Xin M

2017-07-11

Systemic lupus erythematosus, characterized by persistent inflammation, is a complex autoimmune disorder with no known cure. Immunosuppressants used in treatment put patients at a higher risk of infections. New knowledge of disease modulators, such as symbiotic bacteria, can enable fine-tuning of parts of the immune system, rather than suppressing it altogether. Dysbiosis of gut microbiota promotes autoimmune disorders that damage extraintestinal organs. Here we report a role of gut microbiota in the pathogenesis of renal dysfunction in lupus. Using a classical model of lupus nephritis, MRL/lpr, we found a marked depletion of Lactobacillales in the gut microbiota. Increasing Lactobacillales in the gut improved renal function of these mice and prolonged their survival. We used a mixture of 5 Lactobacillus strains (Lactobacillus oris, Lactobacillus rhamnosus, Lactobacillus reuteri, Lactobacillus johnsonii, and Lactobacillus gasseri), but L. reuteri and an uncultured Lactobacillus sp. accounted for most of the observed effects. Further studies revealed that MRL/lpr mice possessed a "leaky" gut, which was reversed by increased Lactobacillus colonization. Lactobacillus treatment contributed to an anti-inflammatory environment by decreasing IL-6 and increasing IL-10 production in the gut. In the circulation, Lactobacillus treatment increased IL-10 and decreased IgG2a that is considered to be a major immune deposit in the kidney of MRL/lpr mice. Inside the kidney, Lactobacillus treatment also skewed the Treg-Th17 balance towards a Treg phenotype. These beneficial effects were present in female and castrated male mice, but not in intact males, suggesting that the gut microbiota controls lupus nephritis in a sex hormone-dependent manner. This work demonstrates essential mechanisms on how changes of the gut microbiota regulate lupus-associated immune responses in mice. Future studies are warranted to determine if these results can be replicated in human subjects.

Aplastic anemia as a feature of systemic lupus erythematosus: a case report and literature review.

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Chalayer, Émilie; Ffrench, Martine; Cathébras, Pascal

2015-06-01

Peripheral cytopenias are common in systemic lupus erythematosus, but bone marrow involvement is rarely reported. Aplastic anemia is the result of immune-mediated destruction of hematopoietic stem cells causing pancytopenia and characterized by an empty bone marrow. This rare but serious disease has been described as an unusual manifestation of systemic lupus erythematosus. We reviewed the 25 cases published in the English language literature and discuss the clinical presentation, outcome, treatment, and pathophysiology of aplastic anemia as a complication of systemic lupus erythematosus. We report here the first case of aplastic anemia associated with systemic lupus erythematosus treated with an allogeneic hematopoietic stem cell transplant. Over one half of patients received concomitantly the diagnoses of systemic lupus erythematosus and aplastic anemia. No clinical or histological features can distinguish primary aplastic anemia from aplastic anemia occurring in systemic lupus erythematosus patients. The overall mortality is about 15% and corticosteroid-based therapy alone or in combination with other immunomodulatory drugs can restore bone marrow function. Systemic lupus erythematosus may be complicated by bone marrow involvement. The diagnosis of peripheral cytopenias should be confirmed by bone marrow aspiration. All these patients should receive cortisone as a first treatment. Plasma exchanges seem to have some efficacy. Other different immunomodulatory therapies were used with variable results.

Pediatric lupus nephritis presenting with terminal renal failure.

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Besouw, Martine T P; Vande Walle, Johan G; Ilias, Mohamad I; Raes, Ann M; Prytula, Agnieszka A; Claeys, Lieve; Dehoorne, Jo L

2016-12-01

A 12-year-old Congolese girl presented with acute renal failure, edema, hypertension, hemoptysis, hematuria, and proteinuria after a history of throat infection. Renal ultrasound showed kidneys of normal size, with increased echogenicity of the cortical parenchyma and decreased corticomedullary differentiation. Other additional investigations showed pancytopenia with decreased complement (low C3 and C4). Antinuclear antibodies were strongly positive, including anti-double stranded DNA. Renal biopsy confirmed severe grade IV lupus nephritis. She was treated with high-dose steroids, mycophenolate mofetil and hydroxychloroquine, in addition to hemodialysis. After one week of intensive treatment, diuresis recovered and dialysis could be stopped after six sessions. We describe an uncommon case of severe lupus nephritis, presenting with terminal renal failure. Since the rarity of this disease presentation, other more common diagnoses have to be considered. Once the diagnosis of lupus nephritis is established, a choice has to be made between the different induction treatment protocols. The patient's ethnic background and other supportive therapies, such as the need for dialysis, can help to make this choice.

B-cell-depleting Therapy in Systemic Lupus Erythematosus

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Ramos-Casals, Manuel; Sanz, Iñaki; Bosch, Xavier; Stone, John H.; Khamashta, Munther A.

2014-01-01

The emergence of a new class of agents (B-cell-depleting therapies) has opened a new era in the therapeutic approach to systemic lupus erythematosus, with belimumab being the first drug licensed for use in systemic lupus erythematosus in more than 50 years. Four agents deserve specific mention: rituximab, ocrelizumab, epratuzumab, and belimumab. Controlled trials have shown negative results for rituximab, promising results for epratuzumab, and positive results for belimumab. Despite these negative results, rituximab is the most-used agent in patients who do not respond or are intolerant to standard therapy and those with life-threatening presentations. B-cell-depleting agents should not be used in patients with mild disease and should be tailored according to individual patient characteristics, including ethnicity, organ involvement, and the immunological profile. Forthcoming studies of B-cell-directed strategies, particularly data from investigations of off-label rituximab use and postmarketing studies of belimumab, will provide new insights into the utility of these treatments in the routine management of patients with systemic lupus erythematosus. PMID:22444096

Study of Flare Assessment in Systemic Lupus Erythematosus Based on Paper Patients

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Isenberg, D; Sturgess, J; Allen, E

2018-01-01

OBJECTIVE: To determine the level of agreement of disease flare severity (distinguishing severe, moderate, and mild flare and persistent disease activity) in a large paper-patient exercise involving 988 individual cases of systemic lupus erythematosus. METHODS: A total of 988 individual lupus cas...

Management of systemic lupus erythematosus during pregnancy: challenges and solutions

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Knight CL

2017-03-01

Full Text Available Caroline L Knight, Catherine Nelson-Piercy Division of Women’s Health, Women’s Health Academic Centre, King’s College London and King’s Health Partners, St Thomas’ Hospital, London, UK Abstract: Systemic lupus erythematosus (SLE is a chronic, multisystem autoimmune disease predominantly affecting women, particularly those of childbearing age. SLE provides challenges in the prepregnancy, antenatal, intrapartum, and postpartum periods for these women, and for the medical, obstetric, and midwifery teams who provide their care. As with many medical conditions in pregnancy, the best maternal and fetal–neonatal outcomes are obtained with a planned pregnancy and a cohesive multidisciplinary approach. Effective prepregnancy risk assessment and counseling includes exploration of factors for poor pregnancy outcome, discussion of risks, and appropriate planning for pregnancy, with consideration of discussion of relative contraindications to pregnancy. In pregnancy, early referral for hospital-coordinated care, involvement of obstetricians and rheumatologists (and other specialists as required, an individual management plan, regular reviews, and early recognition of flares and complications are all important. Women are at risk of lupus flares, worsening renal impairment, onset of or worsening hypertension, preeclampsia, and/or venous thromboembolism, and miscarriage, intrauterine growth restriction, preterm delivery, and/or neonatal lupus syndrome (congenital heart block or neonatal lupus erythematosus. A cesarean section may be required in certain obstetric contexts (such as urgent preterm delivery for maternal and/or fetal well-being, but vaginal birth should be the aim for the majority of women. Postnatally, an ongoing individual management plan remains important, with neonatal management where necessary and rheumatology follow-up. This article explores the challenges at each stage of pregnancy, discusses the effect of SLE on pregnancy and

Automated detection of Lupus white matter lesions in MRI

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Eloy Roura Perez

2016-08-01

Full Text Available Brain magnetic resonance imaging provides detailed information which can be used to detect and segment white matter lesions (WML. In this work we propose an approach to automatically segment WML in Lupus patients by using T1w and fluid-attenuated inversion recovery (FLAIR images. Lupus WML appear as small focal abnormal tissue observed as hyperintensities in the FLAIR images. The quantification of these WML is a key factor for the stratification of lupus patients and therefore both lesion detection and segmentation play an important role. In our approach, the T1w image is first used to classify the three main tissues of the brain, white matter (WM, gray matter (GM and cerebrospinal fluid (CSF, while the FLAIR image is then used to detect focal WML as outliers of its GM intensity distribution. A set of post-processing steps based on lesion size, tissue neighborhood, and location are used to refine the lesion candidates. The proposal is evaluated on 20 patients, presenting qualitative and quantitative results in terms of precision and sensitivity of lesion detection (True Positive Rate (62% and Positive Prediction Value (80% respectively as well as segmentation accuracy (Dice Similarity Coefficient (72%. Obtained results illustrate the validity of the approach to automatically detect and segment lupus lesions. Besides, our approach is publicly available as a SPM8/12 toolbox extension with a simple parameter configuration.

Clinical and serological manifestations associated with interferon-α levels in childhood-onset systemic lupus erythematosus

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Mariana Postal

2012-01-01

Full Text Available OBJECTIVE: To determine the serum levels of interferon alpha in childhood-onset systemic lupus erythematosus patients, their first-degree relatives and healthy controls and to evaluate the associations between serum interferon alpha and disease activity, laboratory findings and treatment features. METHODS: We screened consecutive childhood-onset systemic lupus erythematosus patients in a longitudinal cohort at the pediatric rheumatology unit of the State University of Campinas between 2009 and 2010. All patients demonstrated disease onset before the age of 16. Disease status was assessed according to the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI. Interferon alpha levels were measured using an enzyme-linked immunoabsorbent assay. RESULTS: We included 57 childhood-onset systemic lupus erythematosus patients (mean age 17.33±4.50, 64 firstdegree relatives (mean age 39.95±5.66, and 57 healthy (mean age 19.30±4.97 controls. Serum interferon alpha levels were significantly increased in childhood-onset systemic lupus erythematosus patients compared to their firstdegree relatives and healthy controls. Interferon alpha levels were significantly increased in patients with positive dsDNA antibodies, patients with cutaneous vasculitis, patients with new malar rash and patients who were not receiving medication. Interferon alpha levels correlated with C3 levels and systemic lupus erythematosus Disease Activity Index scores. In addition, we observed an inverse correlation between patient age and interferon alpha levels. CONCLUSION: Interferon alpha may play a role in the pathogenesis of childhood-onset systemic lupus erythematosus, especially in cutaneous manifestations and dsDNA antibody formation. The observation that interferon alpha levels are increased in patients who are not taking medication should be investigated in

Lupus enteritis: from clinical findings to therapeutic management

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2013-01-01

Lupus enteritis is a rare and poorly understood cause of abdominal pain in patients with systemic lupus erythematosus (SLE). In this study, we report a series of 7 new patients with this rare condition who were referred to French tertiary care centers and perform a systematic literature review of SLE cases fulfilling the revised ACR criteria, with evidence for small bowel involvement, excluding those with infectious enteritis. We describe the characteristics of 143 previously published and 7 new cases. Clinical symptoms mostly included abdominal pain (97%), vomiting (42%), diarrhea (32%) and fever (20%). Laboratory features mostly reflected lupus activity: low complement levels (88%), anemia (52%), leukocytopenia or lymphocytopenia (40%) and thrombocytopenia (21%). Median CRP level was 2.0 mg/dL (range 0–8.2 mg/dL). Proteinuria was present in 47% of cases. Imaging studies revealed bowel wall edema (95%), ascites (78%), the characteristic target sign (71%), mesenteric abnormalities (71%) and bowel dilatation (24%). Only 9 patients (6%) had histologically confirmed vasculitis. All patients received corticosteroids as a first-line therapy, with additional immunosuppressants administered either from the initial episode or only in case of relapse (recurrence rate: 25%). Seven percent developed intestinal necrosis or perforation, yielding a mortality rate of 2.7%. Altogether, lupus enteritis is a poorly known cause of abdominal pain in SLE patients, with distinct clinical and therapeutic features. The disease may evolve to intestinal necrosis and perforation if untreated. Adding with this an excellent steroid responsiveness, timely diagnosis becomes primordial for the adequate management of this rare entity. PMID:23642042

Heart rate variability in patients with systemic lupus erythematosus: a systematic review and methodological considerations.

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Matusik, P S; Matusik, P T; Stein, P K

2018-07-01

Aim The aim of this review was to summarize current knowledge about the scientific findings and potential clinical utility of heart rate variability measures in patients with systemic lupus erythematosus. Methods PubMed, Embase and Scopus databases were searched for the terms associated with systemic lupus erythematosus and heart rate variability, including controlled vocabulary, when appropriate. Articles published in English and available in full text were considered. Finally, 11 publications were selected, according to the systematic review protocol and were analyzed. Results In general, heart rate variability, measured in the time and frequency domains, was reported to be decreased in patients with systemic lupus erythematosus compared with controls. In some systemic lupus erythematosus studies, heart rate variability was found to correlate with inflammatory markers and albumin levels. A novel heart rate variability measure, heart rate turbulence onset, was shown to be increased, while heart rate turbulence slope was decreased in systemic lupus erythematosus patients. Reports of associations of changes in heart rate variability parameters with increasing systemic lupus erythematosus activity were inconsistent, showing decreasing heart rate variability or no relationship. However, the low/high frequency ratio was, in some studies, reported to increase with increasing disease activity or to be inversely correlated with albumin levels. Conclusions Patients with systemic lupus erythematosus have abnormal heart rate variability, which reflects cardiac autonomic dysfunction and may be related to inflammatory cytokines but not necessarily to disease activity. Thus measurement of heart rate variability could be a useful clinical tool for monitoring autonomic dysfunction in systemic lupus erythematosus, and may potentially provide prognostic information.

A pediatric case of disseminated mutilating lupus vulgaris: A disgrace for society

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Suresh Kumar Jain

2016-01-01

Full Text Available Lupus vulgaris (LV is a chronic and progressive form of cutaneous tuberculosis. The lesions may sometimes be associated with extensive destruction of tissue resulting in marked disfigurement and morbidity. A high index of suspicion is crucial for early diagnosis and treatment and thereby prevention of cosmetic deformity. Lupus vulgaris presenting as disseminated mutilating lesions in a child is uncommon, especially in today's era. Herein, we report an unusual case of lupus vulgaris with coexistence of multiple ulcerative mutilating lesions over face and classical plaque over distant site (right thigh in a 9 year old girl.

Metabolic syndrome in Iranian patients with systemic lupus erythematosus and its determinants.

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Fatemi, Alimohammad; Ghanbarian, Azadeh; Sayedbonakdar, Zahra; Kazemi, Mehdi; Smiley, Abbas

2018-01-05

The aim of this study was to determine the prevalence of metabolic syndrome (MetS) in Iranian patients with systemic lupus erythematosus (SLE) and its determinants. In a cross-sectional study, 98 patients with SLE and 95 controls were enrolled. Prevalence of MetS was determined based on American Heart Association and National Heart, Lung, and Blood Institute (AHA/NHLBI) and 2009 harmonizing criteria. In addition, demographic features and lupus characteristics such as disease duration, pharmacological treatment, laboratory data, SLE disease activity index (SLEDAI), and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage index (SDI) were recorded. The predictors of MetS were obtained by backward stepwise regression analysis. Using AHA/NHLBI, MetS was observed in 35 (35.7%) patients and 28 (29.8%) controls (P = 0.4). Using harmonizing criteria, MetS was observed in 37 (37.7%) patients and 33 (35.1%) controls (P = 0.7). There was no difference in frequency distribution of MetS components between the patients and the controls. In multivariate regression analysis, low C3, blood urea nitrogen (BUN), and body mass index were independent determinants of MetS in lupus patients. BUN, low C3, and body mass index were the major determinants of MetS in lupus patients.

Low prevalence of Pneumocystis pneumonia in hospitalized patients with systemic lupus erythematosus: review of a clinical data warehouse.

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Kapoor, T M; Mahadeshwar, P; Nguyen, S; Li, J; Kapoor, S; Bathon, J; Giles, J; Askanase, A

2017-12-01

Objective In the era of powerful immunosuppression, opportunistic infections are an increasing concern in systemic lupus erythematosus. One of the best-studied opportunistic infections is Pneumocystis pneumonia; however, the prevalence of Pneumocystis pneumonia in systemic lupus erythematosus is not clearly defined. This study evaluates the prevalence of Pneumocystis pneumonia in hospitalized systemic lupus erythematosus patients, with a focus on validating the Pneumocystis pneumonia and systemic lupus erythematosus diagnoses with clinical information. Methods This retrospective cohort study evaluates the prevalence of Pneumocystis pneumonia in all systemic lupus erythematosus patients treated at Columbia University Medical Center-New York Presbyterian Hospital between January 2000 and September 2014, using electronic medical record data. Patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and patients with renal transplants (including both early and late post-transplant patients) represented immunocompromised control groups. Patients with systemic lupus erythematosus, Pneumocystis pneumonia, HIV/AIDS, or renal transplant were identified using diagnostic codes from the International Classification of Diseases, Ninth Revision (ICD-9). Results Out of 2013 hospitalized systemic lupus erythematosus patients, nine had presumed Pneumocystis pneumonia, yielding a low prevalence of Pneumocystis pneumonia in systemic lupus erythematosus of 0.45%. Three of the nine Pneumocystis pneumonia cases were patients with concomitant systemic lupus erythematosus and HIV/AIDS. Only one of these nine cases was histologically confirmed as Pneumocystis pneumonia, in a patient with concomitant systemic lupus erythematosus and HIV/AIDS and a CD4 count of 13 cells/mm 3 . The prevalence of Pneumocystis pneumonia in renal transplant patients and HIV/AIDS patients was 0.61% and 5.98%, respectively. Conclusion Given the reported high rate of adverse effects

Influence of Education on Disease Activity and Damage in Systemic Lupus Erythematosus: Data From the 1000 Canadian Faces of Lupus.

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George, Angela; Wong-Pak, Andrew; Peschken, Christine A; Silverman, Earl; Pineau, Christian; Smith, C Douglas; Arbillaga, Hector; Zummer, Michel; Bernatsky, Sasha; Hudson, Marie; Hitchon, Carol; Fortin, Paul R; Nevskaya, Tatiana; Pope, Janet E

2017-01-01

To determine whether socioeconomic status assessed by education is associated with disease activity and the risk of organ damage in systemic lupus erythematosus (SLE). Data from the 1000 Canadian Faces of Lupus, a multicenter database of adult SLE patients, was used to compare education as either low (did not complete high school) or high (completed high school or further) for disease activity and damage. Education was also studied as a continuous variable. The relationships between education and SLE outcomes (any organ damage defined as a Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI] score ≥1, serious organ damage [SDI score ≥3], and end-stage renal disease) were evaluated using logistic regression analyses adjusted for age, sex, race/ethnicity, and disease duration. A total of 562 SLE patients met inclusion criteria (mean age 47 years, 91% female, and mean disease duration of 10 years); 81% had high education. The low education group was twice as likely to be work disabled (30%; P education was significantly associated with higher disease activity at enrollment into the 1000 Canadian Faces of Lupus database, after adjustment for age (at entry and at diagnosis), race/ethnicity, and sex (B 1.255 + 0.507 [SE], β = 0.115, P = 0.014). In our adjusted logistic regression models we were unable to demonstrate significant associations between education and SLE damage. Results did not change when varying the education variable. In this cohort, low education was associated cross-sectionally with higher disease activity and work disability, but not damage. © 2016, American College of Rheumatology.

Pregnancy in women with systemic lupus erythematosus.

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Kiss, Emese; Bhattoa, Harjit P; Bettembuk, Peter; Balogh, Adam; Szegedi, Gyula

2002-03-10

Systemic lupus erythematosus (SLE) is an autoimmune disorder which may be affected by hormonal changes, such as those of pregnancy. Women with SLE have increased adverse pregnancy outcomes. A retrospective analysis of the gynecologic and immunologic case history of 140 women with SLE and the outcome of 263 pregnancies in 99 women with SLE. In patients diagnosed with SLE, the proportion of pregnancies ending with live birth at term decreased to one-third compared with three quarters in those without a diagnosis of SLE and the incidence of pre-term deliveries and spontaneous abortions increased by 6.8 and 4.7 times, respectively. When SLE was associated with secondary antiphospholipid (APL) syndrome, and lupus anticoagulant (LA) or beta2-glycoprotein antibodies were present, a further increase in the incidence of pregnancy loss was observed. Pregnancy did not cause a flare-up of SLE in all cases, the disease remained stable in about 30% of the patients. Lupus was mild in the majority of the women who carried out their pregnancy to term. We also observed mothers with active SLE who successfully carried out pregnancies to term. These findings accord with previous literature and should inform rheumatologists, obstetricians and neonatologists who guide patients in their reproductive decisions.

Lupus anticoagulant-hypoprothrombinemia syndrome and catastrophic antiphospholipid syndrome in a patient with antidomain I antibodies.

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Galland, Joris; Mohamed, Shirine; Revuz, Sabine; de Maistre, Emmanuel; de Laat, Bas; Marie, Pierre-Yves; Zuily, Stéphane; Lévy, Bruno; Regnault, Véronique; Wahl, Denis

2016-07-01

Lupus anticoagulant-hypoprothrombinemia syndrome is a rare condition characterized by the association of acquired factor II deficiency and lupus anticoagulant. Contrary to classical antiphospholipid syndrome, it may cause severe life-threatening bleeding (89% of published cases). We report a patient, positive for antidomain I antibodies, with initially primary lupus anticoagulant-hypoprothrombinemia syndrome without previous clinical manifestation or underlying systemic disease. Five years later, he experienced the first systemic lupus erythematous flare. Within a few days, catastrophic antiphospholipid syndrome was diagnosed with heart, liver and kidney involvement. The patient recovered under pulse steroids, intravenous heparin and intravenous immunoglobulins.

The need for a hydromorphological approach to Chilean river management La necesidad de un enfoque hidromorfológico para la gestión de los ríos chilenos

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ANDREA ANDREOLI

2012-09-01

considerar al determinar el estado ecológico de los ríos. La comprensión de cómo las variables hidrológicas y morfológicas interactúan de forma dinámica es sin duda clave para evaluar la presencia o ausencia de un equilibrio dinámico, una condición que, a su vez, fomenta tanto la diversidad de hábitat como el desarrollo sostenible de los ecosistemas acuáticos y ribereños. Los autores concluyen que es necesario cambiar el paradigma actual de gestión aplicado en los ríos chilenos desarrollando una estrategia que permita evaluar las condiciones hidromorfológicas y ecológicas de los ríos. Además, sugieren implementar legislación específica orientada a promover estándares ecológicos y geomorfológicos en la práctica de gestión, con el apoyo de un fortalecimiento y una ampliación de la enseñanza académica de la geomorfología y ecología fluvial.

Management of cardiovascular risk in systemic lupus erythematosus: a systematic review.

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Andrades, C; Fuego, C; Manrique-Arija, S; Fernández-Nebro, A

2017-11-01

Systemic lupus erythematosus is associated with accelerated atherosclerosis and increased risk of cardiovascular complications. The aim of this study was to review the effectiveness of interventions for primary and secondary prevention of cardiovascular events and mortality and to review the effectiveness of interventions for cardiovascular risk factor reduction in systemic lupus erythematosus patients. A systematic review was conducted. Electronic databases Medline and Embase (1961-2015) were searched. Nineteen articles met the inclusion criteria and were selected. Low-calorie and/or low glycaemic index calories may be a useful option for secondary prevention in obese patients with systemic lupus erythematosus, and exercise would be useful in improving the endothelial function measured by flow-mediated dilation in this group of patients. The use of lipid-lowering drugs may improve the lipid profile in patients with systemic lupus erythematosus and hyperlipidaemia, but the effect of this treatment on overall cardiovascular mortality remains unknown. Antiplatelets, anticoagulants, antimalarials and lipid-lowering drugs may be effective in the primary and secondary prevention of major cardiovascular events, such as acute myocardial infarction or stroke. Similarly, lipid-lowering drugs and antimalarial drugs appear to reduce the serum levels of total cholesterol, low-density lipoprotein, glucose, diastolic blood pressure and calcium deposition at the coronary arteries. They may also improve insulin resistance and the level of high-density lipoproteins. It appears that treatment with antihypertensive drugs reduces blood pressure in patients with systemic lupus erythematosus, but the available studies are of low quality.

Systemisk lupus erythematosus i Fyns Amt

DEFF Research Database (Denmark)

Voss, Anne B.; Green, Anders; Junker, Peter

1999-01-01

The incidence and prevalence of systemic lupus erythematosus (SLE) has never been investigated in Denmark, whereas international studies have reached divergent results. In the study patients were ascertained from diagnosis-based registers of inpatients and outpatients, notifications from physicians...

Lupus, discoid on the face (image)

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... by red, raised patches with adherent scales. The skin pores (follicles) may be plugged, and scarring often occurs in older lesions. Approximately 90% of individuals with discoid lupus have only skin involvement as compared to more generalized involvement in ...

Promover la salud mental con mujeres chilenas en desventaja social

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M Soledad Rivera

2004-01-01

Full Text Available Se descrive una parte de la experiencia del proyecto Chileno/Canadiense: “Promover la salud mental de las mujeres chilenas en desventaja social: Los Secretos de Maruja”. Se describen los objetivos, las etapas del proceso, de intervención y los resultados de las evaluaciones preliminares. Con la participación de las mujeres usuárias de los centros de salud, profesionales y autoridades de la comuna de La Pintana, se construyó, aplicó y evaluó un proyecto de intervención para apoyar a las mujeres en la toma de decisiones que favorezcan su salud mental personal, familiar y social. La intervención contempló el diseño, producción, distribución y evaluación de 12 folletos educativos tipo calendarios, cada uno respecto a tres temas de salud mental identificados por las mismas mujeres: Identidad y autoestima, Vínculo y Comunicación y Autocuidado. Además se involucró a las enfermeras que trabajan en los Centros de Salud, quienes incorporaron esta estrategia a la atención de salud habitual y evaluaron su impacto en la identidad, autonomía profesional y en la mejoría de la calidad del cuidado

Angiotensin-converting enzyme insertion/deletion gene polymorphism in Egyptian children with systemic lupus erythematosus: a possible relation to proliferative nephritis.

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Hammad, A; Yahia, S; Laimon, W; Hamed, S M; Shouma, A; Shalaby, N M; Abdel-Hady, D; Ghanem, R; El-Farahaty, R M; El-Bassiony, S R; Hammad, E M

2017-06-01

Introduction Angiotensin-converting enzyme (ACE) is crucial in the pathogenesis of systemic lupus erythematosus through angiotensin II which regulates vascular tone and endothelial functions. Objectives To study the frequency of ACE insertion/deletion (I/D) gene polymorphism in Egyptian children with systemic lupus erythematosus and its possible relation to the renal pathology in cases with lupus nephritis. Subjects and methods The frequency of ACE gene insertion/deletion polymorphism genotypes was determined in 78 Egyptian children with systemic lupus erythematosus and compared to a matched group of 140 healthy controls using polymerase chain reaction. Results The DD genotype of the ACE gene was higher in systemic lupus erythematosus patients when compared to controls ( Plupus erythematosus patients in comparison to controls ( P lupus nephritis group, the DD genotype was significantly higher in those with proliferative lupus nephritis when compared to those with non-proliferative lupus nephritis ( P = 0.02; OR = 1.45; 95% CI = 1.4-1.6). Also, patients with proliferative lupus nephritis showed a higher frequency of the D allele ( P lupus erythematosus and occurrence of proliferative nephritis in Egyptian children.

Cross-cultural validation of a disease-specific patient-reported outcome measure for lupus in Philippines.

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Navarra, S V; Tanangunan, R M D V; Mikolaitis-Preuss, R A; Kosinski, M; Block, J A; Jolly, M

2013-03-01

LupusPRO is a disease-targeted patient-reported outcome measure that was developed and validated among US patients with systemic lupus erythematosus (SLE). We report the cross-cultural validation results of the LupusPRO English-language version among Filipino SLE patients. The 43-item LupusPRO was pretested in 15 SLE individuals, then administered to 106 SLE patients, along with short-form SF36 and the EQ5D visual analogue scale. A mail/drop-back LupusPRO and change in health status item survey were returned within two to three days. Demographics, clinical and serological characteristics, disease activity and damage measured by PGA, SELENA-SLEDAI, LFA Flare, and SLICC-ACR SLE damage index (SDI) were collected. Internal consistency reliability (ICR), test-retest reliability (TRT), convergent validity (corresponding SF36 domains) and criterion validity (against general health and disease activity measures) were tested. Reported p values are two tailed. A total of 121 Filipino SLE subjects (95% women, median age 31.0 ± 16 years) with at least a high school level of English instruction participated. Median (IQR) PGA, SLEDAI and SDI were 0.0 (1.0), 2.0 (10) and 0 (1), respectively. ICR exceeded 0.7 for all domains except the lupus symptoms domain. TRT was greater than 0.85 for all LupusPRO domains. Convergent and criterion validity were observed against corresponding SF36 domains and disease activity measures. The tool was well received by patients. Confirmatory factor analysis showed good fit. English LupusPRO has fair psychometric properties among SLE patients in the Philippines, and is now available for inclusion in clinical trials and longitudinal studies to test responsiveness to change.

Minocycline induced lupus with yellow colored chylous exudative pleural effusion

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Daniel Starobin

2017-01-01

Full Text Available Ninety years old male was admitted to hospital due to breathlessness. The prominent findings were extensive blue-grey skin pigmentation and large left chylothorax. Drug induced lupus was diagnosed due to either minocycline chronic treatment or no alternative illness to explain his sub-acute disease. Minocycline therapy was stopped with gradual improvement of pleural effusion and skin discoloration. This case is the first presentation of minocycline induced lupus with chylothorax.

Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction.

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Furumoto, Yasuko; Smith, Carolyne K; Blanco, Luz; Zhao, Wenpu; Brooks, Stephen R; Thacker, Seth G; Abdalrahman, Zarzour; Sciumè, Giuseppe; Tsai, Wanxia L; Trier, Anna M; Nunez, Leti; Mast, Laurel; Hoffmann, Victoria; Remaley, Alan T; O'Shea, John J; Kaplan, Mariana J; Gadina, Massimo

2017-01-01

Dysregulation of innate and adaptive immune responses contributes to the pathogenesis of systemic lupus erythematosus (SLE) and its associated premature vascular damage. No drug to date targets both systemic inflammatory disease and the cardiovascular complications of SLE. Tofacitinib is a JAK inhibitor that blocks signaling downstream of multiple cytokines implicated in lupus pathogenesis. While clinical trials have shown that tofacitinib exhibits significant clinical efficacy in various autoimmune diseases, its role in SLE and the associated vascular pathology remains to be characterized. MRL/lpr lupus-prone mice were administered tofacitinib or vehicle by gavage for 6 weeks (therapeutic arm) or 8 weeks (preventive arm). Nephritis, skin inflammation, serum levels of autoantibodies and cytokines, mononuclear cell phenotype and gene expression, neutrophil extracellular traps (NETs) release, endothelium-dependent vasorelaxation, and endothelial differentiation were compared in treated and untreated mice. Treatment with tofacitinib led to significant improvement in measures of disease activity, including nephritis, skin inflammation, and autoantibody production. In addition, tofacitinib treatment reduced serum levels of proinflammatory cytokines and interferon responses in splenocytes and kidney tissue. Tofacitinib also modulated the formation of NETs and significantly increased endothelium-dependent vasorelaxation and endothelial differentiation. The drug was effective in both preventive and therapeutic strategies. Tofacitinib modulates the innate and adaptive immune responses, ameliorates murine lupus, and improves vascular function. These results indicate that JAK inhibitors have the potential to be beneficial in SLE and its associated vascular damage. © 2016, American College of Rheumatology.

Democracia y educación de John Dewey presente en el problema nacional de darío salas: a propósito del centenario de ambas obras

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Jaime Caiceo Escudero

2018-03-01

Full Text Available El año 2016 se celebró con diversas actividades el centenario de la publicación de una de las obras más significativas del educador norteamericano John Dewey, Democracia y Educación (1916; el año pasado (2017 se conmemoró el centenario de la obra más significativa del educador chileno Darío Salas, El Problema Nacional. Bases para la Reconstrucción de Nuestro Sistema Escolar Primario (1917. En el contexto de ambos centenarios se analiza la influencia de la obra del pedagogo norteamericano en el texto del educador chileno.

Subacute cutaneous lupus erythematosus presenting as poikiloderma.

LENUS (Irish Health Repository)

Hughes, R

2012-02-01

Subacute cutaneous lupus erythematosus (SCLE) is a recognised variant of lupus erythematosus (LE), which accounts for 10-15% of all cases of cutaneous LE, occurring most commonly in young to middle-aged white women. Diagnosis is based on the detection of anti-Ro\\/SS-A antibodies in the skin and serum, characteristic clinical and histological cutaneous involvement, and relatively mild systemic involvement. Several unusual variants of SCLE have been reported including erythrodermic SCLE, SCLE with vitiligo-like lesions, acral SCLE and bullous SCLE. Poikoilodermatous SCLE is a recognised but rare variant of SCLE. There are currently only two case reports, comprising five individual cases, in the literature. We present a case of SCLE in which the main clinical findings were an extensive photodistributed poikilodermatous rash and alopecia.

Mesenchymal Stem Cells Control Complement C5 Activation by Factor H in Lupus Nephritis

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Haijun Ma

2018-06-01

Full Text Available Lupus nephritis (LN is one of the most severe complications of systemic lupus erythematosus (SLE caused by uncontrolled activation of the complement system. Mesenchymal stem cells (MSCs exhibit clinical efficacy for severe LN in our previous studies, but the underlying mechanisms of MSCs regulating complement activation remain largely unknown. Here we show that significantly elevated C5a and C5b-9 were found in patients with LN, which were notably correlated with proteinuria and different renal pathological indexes of LN. MSCs suppressed systemic and intrarenal activation of C5, increased the plasma levels of factor H (FH, and ameliorated renal disease in lupus mice. Importantly, MSCs transplantation up-regulated the decreased FH in patients with LN. Mechanistically, interferon-α enhanced the secretion of FH by MSCs. These data demonstrate that MSCs inhibit the activation of pathogenic C5 via up-regulation of FH, which improves our understanding of the immunomodulatory mechanisms of MSCs in the treatment of lupus nephritis. Keywords: Lupus nephritis, C5, MSCs, FH

Renal Tubular Function in Systemic Lupus Erythematosus*

African Journals Online (AJOL)

immune' diseases such as. Sjogren's syndrome,'" systemic lupus erythematosus. (SLE),3 alveolitis' and chronic active hepatitis.' The reported abnormalities of renal tubular function include impairment of acid excretion and urinary concentration.

Lupus anticoagulant, disease activity and low complement in the first trimester are predictive of pregnancy loss.

Science.gov (United States)

Mankee, Anil; Petri, Michelle; Magder, Laurence S

2015-01-01

Multiple factors, including proteinuria, antiphospholipid syndrome, thrombocytopenia and hypertension, are predictive of pregnancy loss in systemic lupus erythematosus (SLE). In the PROMISSE study of predictors of pregnancy loss, only a battery of lupus anticoagulant tests was predictive of a composite of adverse pregnancy outcomes. We examined the predictive value of one baseline lupus anticoagulant test (dilute Russell viper venom time) with pregnancy loss in women with SLE. From the Hopkins Lupus Cohort, there were 202 pregnancies from 175 different women after excluding twin pregnancies and pregnancies for which we did not have a first trimester assessment of lupus anticoagulant. We determined the percentage of women who had a pregnancy loss in groups defined by potential risk factors. The lupus anticoagulant was determined by dilute Russell viper venom time with appropriate mixing and confirmatory testing. Generalised estimating equations were used to calculate p values, accounting for repeated pregnancies in the same woman. The age at pregnancy was 40 (3%). 55% were Caucasian and 34% African-American. Among those with lupus anticoagulant during the first trimester, 6/16 (38%) experienced a pregnancy loss compared with only 16/186 (9%) of other pregnancies (p=0.003). In addition, those with low complement or higher disease activity had a higher rate of pregnancy loss than those without (p=0.049 and 0.005, respectively). In contrast, there was no association between elevated anticardiolipin in the first trimester and pregnancy loss. The strongest predictor of pregnancy loss in SLE in the first trimester is the lupus anticoagulant. In addition, moderate disease activity by the physician global assessment and low complement measured in the first trimester were predictive of pregnancy loss. These data suggest that treatment of the lupus anticoagulant could be considered, even in the absence of history of pregnancy loss.

Type I interferon signature in systemic lupus erythematosus.

Science.gov (United States)

Bezalel, Shira; Guri, Keren Mahlab; Elbirt, Daniel; Asher, Ilan; Sthoeger, Zev Moshe

2014-04-01

Type I interferons (IFN) are primarily regarded as an inhibitor of viral replication. However, type I IFN, mainly IFNalpha, plays a major role in activation of both the innate and adaptive immune systems. Systemic lupus erythematosus (SLE) is a chronic, multi-systemic, inflammatory autoimmune disease with undefined etiology. SLE is characterized by dysregulation of both the innate and the adaptive immune systems. An increased expression of type I IFN-regulated genes, termed IFN signature, has been reported in patients with SLE. We review here the role of IFNalpha in the pathogenesis and course of SLE and the possible role of IFNalpha inhibition as a novel treatment for lupus patients.

Técnicas de ensamblaje anatómico aplicadas al análisis de entierros secundarios: el caso del sitio Laguna los Chilenos 1 (ptdo. de Tornquist, pcia. de Buenos Aires

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Carlotto, Ana

2001-01-01

Full Text Available En los estudios bioarqueológicos contemporáneos, la unidad de análisis principal es el individuo, en tanto integrante de una muestra con significado poblacional. De allí la necesidad de identificar, aislar y reconstruir individuos a partir de conjuntos óseos con distinto grado de preservación e integridad debido a la acción de diferentes procesos pre y postdepositacionales. En los entierros secundarios, que consisten usualmente en agrupaciones desarticuladas de elementos óseos, la unidad individual se pierde, siendo necesario implementar técnicas de ensamblaje anatómico (bilateral e intermembral para su restitución. En el caso del entierro secundario del sitio Laguna Los Chilenos 1 (NISP= 2033; NMI= 14; 470 ± 80 años radiocarbónicos AP, localizado en la llanura situada al sur del sistema serrano de Ventania (Pcia. de Buenos Aires, se aplicaron diversas técnicas de identificación y de ensamblaje anatómico. Las mismas se basaron en el registro, para cada unidad anatómica, de a sexo y edad probable, b atributos no métricos tales como textura, coloración, marcas de corte, estado de conservación, etc. y c atributos métricos longitudinales y transversales de huesos largos y de elementos de las cinturas escapular y pélvica. En el presente trabajo se expondrán los resultados obtenidos, y se discutirá la eficiencia de las técnicas empleadas a través del uso de diferentes indicadores (v.g. índice de integridad anatómica individual.

TRACING THE MAGNETIC FIELD MORPHOLOGY OF THE LUPUS I MOLECULAR CLOUD

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Franco, G. A. P. [Departamento de Física—ICEx—UFMG, Caixa Postal 702, 30.123-970 Belo Horizonte (Brazil); Alves, F. O., E-mail: franco@fisica.ufmg.br, E-mail: falves@mpe.mpg.de [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstr. 1, D-85748 Garching (Germany)

2015-07-01

Deep R-band CCD linear polarimetry collected for fields with lines of sight toward the Lupus I molecular cloud is used to investigate the properties of the magnetic field within this molecular cloud. The observed sample contains about 7000 stars, almost 2000 of them with a polarization signal-to-noise ratio larger than 5. These data cover almost the entire main molecular cloud and also sample two diffuse infrared patches in the neighborhood of Lupus I. The large-scale pattern of the plane-of-sky projection of the magnetic field is perpendicular to the main axis of Lupus I, but parallel to the two diffuse infrared patches. A detailed analysis of our polarization data combined with the Herschel/SPIRE 350 μm dust emission map shows that the principal filament of Lupus I is constituted by three main clumps that are acted on by magnetic fields that have different large-scale structural properties. These differences may be the reason for the observed distribution of pre- and protostellar objects along the molecular cloud and the cloud’s apparent evolutionary stage. On the other hand, assuming that the magnetic field is composed of large-scale and turbulent components, we find that the latter is rather similar in all three clumps. The estimated plane-of-sky component of the large-scale magnetic field ranges from about 70 to 200 μG in these clumps. The intensity increases toward the Galactic plane. The mass-to-magnetic flux ratio is much smaller than unity, implying that Lupus I is magnetically supported on large scales.

Nail fold Capillaroscopic Findings in Iranian Patients with Systemic Lupus Erythematosus

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Alireza Rajaei

2016-10-01

Full Text Available Background: Systemic Lupus Erythematosus is a progressive autoimmune disease with a wide range of morphological and functional changes in microscopic examination of small blood vessels. Identification of vascular diseases at early stage, plays an essential role in the prevention of its’ vascular complications. Nailfold capillaroscopy (NFC is a non-invasive, easy, painless, and accurate method for evaluation of microcirculation and could be used for this purpose. The vast majority of studies on capillaroscopy in lupus patients have shown that changes are not specified to lupus –unlike Systemic Sclerosis- and are more likely to overlap with other diseases. Therefore, it was decided to check capillaroscopic changes and evaluate morphological changes and capillary structure in terms of quality and quantity in lupus patients.Materials and Methods: Nail fold capillaroscopic findings of 114 patients aged 19-75 years old were reviewed in this study. The results were categorized as: a normal, b non-specific morphological abnormalities, and c Scleroderma-like pattern.  Results were analyzed qualitatively and quantitatively using SPSS 21 software. "Chi square" test was used to analyze the relationships between variables (P<0.05 was considered significant.Results: Our results show that Lupus –independent of any other microvascular risk factor can significantly affect the morphology and structure of blood circulation and these changes are shown with detail by nail fold capillaroscopy.Conclusion: Most of the findings are in line with similar studies performed by other investigators in this field. However, no specific pattern was recognized and microbleeding was higher in our patients with scleroderma-like pattern of involvement.

TRACING THE MAGNETIC FIELD MORPHOLOGY OF THE LUPUS I MOLECULAR CLOUD

International Nuclear Information System (INIS)

Franco, G. A. P.; Alves, F. O.

2015-01-01

Deep R-band CCD linear polarimetry collected for fields with lines of sight toward the Lupus I molecular cloud is used to investigate the properties of the magnetic field within this molecular cloud. The observed sample contains about 7000 stars, almost 2000 of them with a polarization signal-to-noise ratio larger than 5. These data cover almost the entire main molecular cloud and also sample two diffuse infrared patches in the neighborhood of Lupus I. The large-scale pattern of the plane-of-sky projection of the magnetic field is perpendicular to the main axis of Lupus I, but parallel to the two diffuse infrared patches. A detailed analysis of our polarization data combined with the Herschel/SPIRE 350 μm dust emission map shows that the principal filament of Lupus I is constituted by three main clumps that are acted on by magnetic fields that have different large-scale structural properties. These differences may be the reason for the observed distribution of pre- and protostellar objects along the molecular cloud and the cloud’s apparent evolutionary stage. On the other hand, assuming that the magnetic field is composed of large-scale and turbulent components, we find that the latter is rather similar in all three clumps. The estimated plane-of-sky component of the large-scale magnetic field ranges from about 70 to 200 μG in these clumps. The intensity increases toward the Galactic plane. The mass-to-magnetic flux ratio is much smaller than unity, implying that Lupus I is magnetically supported on large scales

Leptin levels in patients with systemic lupus erythematosus inversely correlate with regulatory T cell frequency.

Science.gov (United States)

Wang, X; Qiao, Y; Yang, L; Song, S; Han, Y; Tian, Y; Ding, M; Jin, H; Shao, F; Liu, A

2017-11-01

Leptin levels are increased in patients with systemic lupus erythematosus (SLE) but little is known on how this correlates with several disease characteristics including the frequency of regulatory T cells (Tregs). Here we compared serum leptin levels with frequency of circulating Tregs in 47 lupus patients vs. 25 healthy matched controls. Correlations with lupus disease activity were also analyzed, as well as Treg proliferation potential. It was found that leptin was remarkably increased in SLE patients as compared to controls, particularly in SLE patients with moderate and severe active SLE, and the increase correlated with disease activity. Importantly, increased leptin in lupus patients inversely correlated with the frequency of Tregs but not in controls, and leptin neutralization resulted in the expansion of Tregs ex vivo. Thus, hyperleptinemia in lupus patients correlates directly with disease activity and inversely with Treg frequency. The finding that leptin inhibition expands Tregs in SLE suggests possible inhibition of this molecule for an enhanced Treg function in the disease.

Bilateral acute lupus pneumonitis in a case of rhupus syndrome

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Supriya Sarkar

2012-01-01

Full Text Available Rhupus syndrome, the overlap of rheumatoid arthritis (RA and systemic lupus erythematosus (SLE, is an extremely uncommon condition. Organ damages found due to SLE are usually mild in rhupus. Lupus pneumonitis in rhupus syndrome has not been reported worldwide. We are reporting a 23-year-old female with bilateral symmetric erosive arthritis, oral ulcer, alopecia, polyserositis, anemia, leucopenia, positive RA-factor, anti nuclear antibody (ANA and anti ds-DNA. She presented with acute onset dyspnea, high fever, chest pain, tachycardia, tachypnea, hypoxia and respiratory alkalosis. High resolution computed tomography (HRCT-thorax showed bilateral, basal consolidation with air bronchogram. Repeated sputum and single broncho alveolar lavage (BAL fluid examination revealed no organism or Hemosiderin-laden macrophage. The diagnosis of rhupus was confirmed by combined manifestations of RA and SLE, and the diagnosis of acute lupus pneumonitis was established by clinico-radiological picture and by excluding other possibilities.

Inteligencia y Conductas Delictuales en Adolescentes Chilenos

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Pedro Rioseco

2012-05-01

Full Text Available Este estudio compara el rendimiento intelectual de 100 jóvenes varones (12-17años que han infringido la ley, con el de 100 jóvenes no infractores. Los resultados indican quelos jóvenes infractores de ley presentan una mayor proporción de CIs totales inferiores al promedioen comparación con los jóvenes no infractores. Al descontar el efecto de la escolarización y NSE,las diferencias de CI entre ambos grupos siguen siendo significativas, aunque menos extremas. Losresultados concuerdan con los hallazgos de otros estudios respecto al menor CI en jóvenes infractores de ley, particularmente en el CI verbal. Estos resultados son de importancia en la planificación deestrategias de rehabilitación, reescolarización y reinserción social de estos adolescentes

A multicenter study of outcome in systemic lupus erythematosus. II. Causes of death.

Science.gov (United States)

Rosner, S; Ginzler, E M; Diamond, H S; Weiner, M; Schlesinger, M; Fries, J F; Wasner, C; Medsger, T A; Ziegler, G; Klippel, J H; Hadler, N M; Albert, D A; Hess, E V; Spencer-Green, G; Grayzel, A; Worth, D; Hahn, B H; Barnett, E V

1982-06-01

Causes of death were examined for 1,103 systemic lupus erythematosus patients who were followed from 1965 to 1978 at 9 centers that participated in the Lupus Survival Study Group. A total of 222 patients (20%) died. Lupus-related organ system involvement (mainly active nephritis) and infection were the most frequent primary causes of death. Causes of death were similar throughout the followup period. Hemodialysis had little impact on the length of survival for patients with nephritis. Active central nervous system disease and myocardial infarction were infrequent causes of death. There were no deaths from malignancy.

Cytokines in relation to autoantibodies before onset of symptoms for systemic lupus erythematosus.

Science.gov (United States)

Eriksson, C; Rantapää-Dahlqvist, S

2014-06-01

A number of cytokines and chemokines were analysed and related to autoantibodies in blood samples pre-dating the onset of symptoms of systemic lupus erythematosus. Thirty-five patients with systemic lupus erythematosus (American College of Rheumatology criteria) were identified as having donated blood samples, prior to symptom onset, to the Biobank of northern Sweden. Altogether, 140 age- and sex-matched controls were also identified. The concentrations of interferon-α, interleukin-4, interleukin-9, interleukin-10, interferon inducible protein-10 and monocyte chemotactic protein-1 were analysed using multiplex technology and related to autoantibodies (ANA, ENA, anti-dsDNA and anti-histone antibodies) analysed from the same blood sample. The interferon-γ inducible protein-10 levels were higher in the pre-symptomatic individuals than in controls (p systemic lupus erythematosus. An increased concentration of interferon-γ inducible protein-10 pre-dated the onset of systemic lupus erythematosus and was related to autoantibodies before the onset of disease. The levels of interferon-γ inducible protein-10 and interferon-α were correlated. These findings support the proposal that the interferon system is important early in the pathogenesis of systemic lupus erythematosus and autoantibody formation. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

MR imaging findings suggestive of posterior reversible encephalopathy syndrome in adolescents with systemic lupus erythematosus

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Muscal, Eyal; De Guzman, Marietta M.; Myones, Barry L. [Texas Children' s Hospital, Baylor College of Medicine and Pediatric Rheumatology Center, Houston, TX (United States); Traipe, Elfrides; Hunter, Jill V. [Texas Children' s Hospital, Baylor College of Medicine and Diagnostic Imaging, Houston, TX (United States); Brey, Robin L. [University of Texas Health Science Center at San Antonio, Department of Neurology, San Antonio, TX (United States)

2010-07-15

Endothelial damage, hypertension and cytotoxic medications may serve as risk factors for the posterior reversible encephalopathy syndrome (PRES) in systemic lupus erythematosus. There have been few case reports of these findings in pediatric lupus patients. We describe clinical and neuroimaging findings in children and adolescents with lupus and a PRES diagnosis. We identified all clinically acquired brain MRIs of lupus patients at a tertiary care pediatric hospital (2002-2008). We reviewed clinical features, conventional MRI and diffusion-weighted imaging (DWI) findings of patients with gray- and white-matter changes suggestive of vasogenic edema and PRES. Six pediatric lupus patients presenting with seizures and altered mental status had MRI findings suggestive of PRES. In five children clinical and imaging changes were seen in conjunction with hypertension and active renal disease. MRI abnormalities were diffuse and involved frontal regions in five children. DWI changes reflected increased apparent diffusivity coefficient (unrestricted diffusion in all patients). Clinical and imaging changes significantly improved with antihypertensive and fluid management. MRI changes suggestive of vasogenic edema and PRES may be seen in children with active lupus and hypertension. The differential diagnosis of seizures and altered mental status should include PRES in children, as it does in adults. (orig.)

MR imaging findings suggestive of posterior reversible encephalopathy syndrome in adolescents with systemic lupus erythematosus

International Nuclear Information System (INIS)

Muscal, Eyal; De Guzman, Marietta M.; Myones, Barry L.; Traipe, Elfrides; Hunter, Jill V.; Brey, Robin L.

2010-01-01

Endothelial damage, hypertension and cytotoxic medications may serve as risk factors for the posterior reversible encephalopathy syndrome (PRES) in systemic lupus erythematosus. There have been few case reports of these findings in pediatric lupus patients. We describe clinical and neuroimaging findings in children and adolescents with lupus and a PRES diagnosis. We identified all clinically acquired brain MRIs of lupus patients at a tertiary care pediatric hospital (2002-2008). We reviewed clinical features, conventional MRI and diffusion-weighted imaging (DWI) findings of patients with gray- and white-matter changes suggestive of vasogenic edema and PRES. Six pediatric lupus patients presenting with seizures and altered mental status had MRI findings suggestive of PRES. In five children clinical and imaging changes were seen in conjunction with hypertension and active renal disease. MRI abnormalities were diffuse and involved frontal regions in five children. DWI changes reflected increased apparent diffusivity coefficient (unrestricted diffusion in all patients). Clinical and imaging changes significantly improved with antihypertensive and fluid management. MRI changes suggestive of vasogenic edema and PRES may be seen in children with active lupus and hypertension. The differential diagnosis of seizures and altered mental status should include PRES in children, as it does in adults. (orig.)

Successful treatment of massive ascites due to lupus peritonitis with hydroxychloroquine in old- onset lupus erythematosus.

Science.gov (United States)

Hammami, Sonia; Bdioui, Fethia; Ouaz, Afef; Loghmari, Hichem; Mahjoub, Sylvia; Saffar, Hamouda

2014-01-01

Systemic lupus erythematous (SLE) is an auto-immune disease with multiple organ involvements that occurs mainly in young women. Literature data suggest that serositis is more frequent in late-onset SLE. However, peritoneal serositis with massive ascites is an extremely rare manifestation. We report a case of old-onset lupus peritonitis treated successfully by Hydroxychloroquine. A 77-year-old Tunisian woman was hospitalized because of massive painful ascites. Her family history did not include any autoimmune disease. She was explored 4 years prior to admission for exudative pleuritis of the right lung without any established diagnosis. Physical examination showed only massive ascites. Laboratory investigations showed leucopenia: 3100/mm3, lymphopenia: 840/mm3 and trace protein (0.03 g/24 h). Ascitic fluid contained 170 cells mm(3) (67% lymphocytes), 46 g/L protein, but no malignant cells. The main etiologies of exudative ascites were excluded. She had markedly elevated anti-nuclear antibody (ANA) titer of 1/1600 and a significantly elevated titer of antibody to double-stranded DNA (83 IU/mL) with hypo-complementemia (C3 levl was at 67 mg/dL). Antibody against the Smith antigen was also positive. Relying on these findings, the patient was diagnosed with SLE and treated with Hydroxychloroquine 200 mg daily in combination with diuretics. One month later, there was no detectable ascitic fluid and no pleural effusions. Five months later she remained free from symptoms while continuing to take chloroquine. This case was characterized by old age of onset of SLE, the extremely rare initial presentation with lupus peritonitis and massive painful ascites with dramatic response to only hydroxychloroquine treatment.

Mannose-binding lectin polymorphisms and susceptibility to infection in systemic lupus erythematosus

DEFF Research Database (Denmark)

Garred, P; Madsen, H O; Halberg, P

1999-01-01

To determine whether variant alleles in the coding portion of the mannose-binding lectin (MBL) gene are associated with increased susceptibility to systemic lupus erythematosus (SLE) and concomitant infections.......To determine whether variant alleles in the coding portion of the mannose-binding lectin (MBL) gene are associated with increased susceptibility to systemic lupus erythematosus (SLE) and concomitant infections....

A quality-of-life study of cutaneous lupus erythematosus.

Science.gov (United States)

Batalla, A; García-Doval, I; Peón, G; de la Torre, C

2013-11-01

The study of quality of life in patients with skin disorders has become more important in recent decades. In the case of lupus erythematosus, most quality-of-life studies have focused on the systemic form of the disease, with less attention being paid to the cutaneous form. The main objective of this study was to evaluate quality of life in patients with cutaneous lupus erythematosus (CLE) using a dermatology-specific questionnaire: the Dermatology Life Quality Index (DLQI). Our secondary objective was to investigate associations between DLQI scores and other aspects of the disease. Thirty-six patients with CLE completed the DLQI questionnaire. Other factors assessed were disease severity (measured using the Cutaneous Lupus Erythematosus Disease Area and Severity Index), time since diagnosis, body surface area affected, previous and current treatments, and the presence of criteria for systemic lupus erythematosus (SLE). According to the DLQI, CLE had a moderate, very large, or extremely large effect on quality of life in 50% of the patients analyzed (18/36). No significant associations were found between DLQI scores and disease severity, time since diagnosis, body surface area affected, number, type, or duration of pharmacologic treatments, or the presence or absence of SLE criteria. CLE has a significant and lasting effect on patient quality of life. This effect is probably primarily due to multiple factors, including the chronic nature of the disease, the visibility of the lesions, and the fact that they can cause disfigurement. Copyright © 2012 Elsevier España, S.L. and AEDV. All rights reserved.

Infodemiology of systemic lupus erythematous using Google Trends.

Science.gov (United States)

Radin, M; Sciascia, S

2017-07-01

Objective People affected by chronic rheumatic conditions, such as systemic lupus erythematosus (SLE), frequently rely on the Internet and search engines to look for terms related to their disease and its possible causes, symptoms and treatments. 'Infodemiology' and 'infoveillance' are two recent terms created to describe a new developing approach for public health, based on Big Data monitoring and data mining. In this study, we aim to investigate trends of Internet research linked to SLE and symptoms associated with the disease, applying a Big Data monitoring approach. Methods We analysed the large amount of data generated by Google Trends, considering 'lupus', 'relapse' and 'fatigue' in a 10-year web-based research. Google Trends automatically normalized data for the overall number of searches, and presented them as relative search volumes, in order to compare variations of different search terms across regions and periods. The Menn-Kendall test was used to evaluate the overall seasonal trend of each search term and possible correlation between search terms. Results We observed a seasonality for Google search volumes for lupus-related terms. In the Northern hemisphere, relative search volumes for 'lupus' were correlated with 'relapse' (τ = 0.85; p = 0.019) and with fatigue (τ = 0.82; p = 0.003), whereas in the Southern hemisphere we observed a significant correlation between 'fatigue' and 'relapse' (τ = 0.85; p = 0.018). Similarly, a significant correlation between 'fatigue' and 'relapse' (τ = 0.70; p < 0.001) was seen also in the Northern hemisphere. Conclusion Despite the intrinsic limitations of this approach, Internet-acquired data might represent a real-time surveillance tool and an alert for healthcare systems in order to plan the most appropriate resources in specific moments with higher disease burden.

[Systemic lupus erythematosus masking the acquired immunodeficiency syndrome. A report on four cases].

Science.gov (United States)

Kotyla, Przemysław; Kucharz, Eugeniusz J

2012-01-01

Systemic lupus erythematosus (SLE) is a systemic inflammatory disease of connective tissue with an unknown etiology and a rich clinical picture with involvement of multiple organs. Given the rich symptomatology, application of the current classification criteria is associated with a significant risk of attributing symptoms of other pathologies to lupus and/or other connective tissue disease. Inherited and acquired immune deficiencies may sometimes demonstrate a lupus-like clinical symptomatology. In this work we reviewed 4 of cases referred to the Department of Internal Diseases and Rheumatology of the Silesian Medical University in Katowice with suspected or confirmed systemic lupus erythematosus. A positive anti-HIV antibody test led to the diagnosis of the acquired immunodeficiency syndrome (AIDS). Due to the close similarity of the clinical picture and the presence of antinuclear antibodies in both diseases, the authors postulate that the anti-HIV antibody test should be done routinely in patients with connective tissue diseases.

Role of MHC-Linked Susceptibility Genes in the Pathogenesis of Human and Murine Lupus

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Manfred Relle

2012-01-01

Full Text Available Systemic lupus erythematosus (SLE is a chronic autoimmune disease characterized by the production of autoantibodies against nuclear antigens and a systemic inflammation that can damage a broad spectrum of organs. SLE patients suffer from a wide variety of symptoms, which can affect virtually almost any tissue. As lupus is difficult to diagnose, the worldwide prevalence of SLE can only be roughly estimated to range from 10 and 200 cases per 100,000 individuals with dramatic differences depending on gender, ethnicity, and location. Although the treatment of this disease has been significantly ameliorated by new therapies, improved conventional drug therapy options, and a trained expert eye, the underlying pathogenesis of lupus still remain widely unknown. The complex etiology reflects the complex genetic background of the disease, which is also not well understood yet. However, in the past few years advances in lupus genetics have been made, notably with the publication of genome-wide association studies (GWAS in humans and the identification of susceptibility genes and loci in mice. This paper reviews the role of MHC-linked susceptibility genes in the pathogenesis of systemic lupus erythematosus.

Myocardial perfusion abnormalities in asymptomatic patients with systemic lupus erythematosus

International Nuclear Information System (INIS)

Hosenpud, J.D.; Montanaro, A.; Hart, M.V.; Haines, J.E.; Specht, H.D.; Bennett, R.M.; Kloster, F.E.

1984-01-01

Accelerated coronary artery disease and myocardial infarction in young patients with systemic lupus erythematosus is well documented; however, the prevalence of coronary involvement is unknown. Accordingly, 26 patients with systemic lupus were selected irrespective of previous cardiac history to undergo exercise thallium-201 cardiac scintigraphy. Segmental perfusion abnormalities were present in 10 of the 26 studies (38.5 percent). Five patients had reversible defects suggesting ischemia, four patients had persistent defects consistent with scar, and one patient had both reversible and persistent defects in two areas. There was no correlation between positive thallium results and duration of disease, amount of corticosteroid treatment, major organ system involvement or age. Only a history of pericarditis appeared to be associated with positive thallium-201 results (p less than 0.05). It is concluded that segmental myocardial perfusion abnormalities are common in patients with systemic lupus erythematosus. Whether this reflects large-vessel coronary disease or small-vessel abnormalities remains to be determined

Shrinking lung syndrome complicating pediatric systemic lupus erythematosus

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Burns, Natalie S. [University of Washington Medical Center, Department of Radiology, Seattle, WA (United States); Stevens, Anne M. [Seattle Children' s Hospital, Division of Rheumatology, Department of Pediatrics, Seattle, WA (United States); Iyer, Ramesh S. [University of Washington School of Medicine, Seattle Children' s Hospital, Department of Radiology, Seattle, WA (United States)

2014-10-15

Systemic lupus erythematosis (SLE) can affect the lungs and pleura, usually manifesting with pleural effusions or diffuse parenchymal disease. A rare manifestation of SLE is shrinking lung syndrome, a severe restrictive respiratory disorder. While pleuropulmonary complications of pediatric SLE are common, shrinking lung syndrome is exceedingly rare in children. We present a case of a 13-year-old girl previously diagnosed with lupus, who developed severe dyspnea on exertion and restrictive pulmonary physiology. Her chest radiographs on presentation demonstrated low lung volumes, and CT showed neither pleural nor parenchymal disease. Fluoroscopy demonstrated poor diaphragmatic excursion. While shrinking lung syndrome is described and studied in adults, there is only sparse reference to shrinking lung syndrome in children. (orig.)

Shrinking lung syndrome complicating pediatric systemic lupus erythematosus

International Nuclear Information System (INIS)

Burns, Natalie S.; Stevens, Anne M.; Iyer, Ramesh S.

2014-01-01

Systemic lupus erythematosis (SLE) can affect the lungs and pleura, usually manifesting with pleural effusions or diffuse parenchymal disease. A rare manifestation of SLE is shrinking lung syndrome, a severe restrictive respiratory disorder. While pleuropulmonary complications of pediatric SLE are common, shrinking lung syndrome is exceedingly rare in children. We present a case of a 13-year-old girl previously diagnosed with lupus, who developed severe dyspnea on exertion and restrictive pulmonary physiology. Her chest radiographs on presentation demonstrated low lung volumes, and CT showed neither pleural nor parenchymal disease. Fluoroscopy demonstrated poor diaphragmatic excursion. While shrinking lung syndrome is described and studied in adults, there is only sparse reference to shrinking lung syndrome in children. (orig.)

Streptococcus pneumoniae necrotizing fasciitis in systemic lupus erythematosus.

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Sánchez, A; Robaina, R; Pérez, G; Cairoli, E

2016-04-01

Necrotizing fasciitis is a rapidly progressive destructive soft tissue infection with high mortality. Streptococcus pneumoniae as etiologic agent of necrotizing fasciitis is extremely unusual. The increased susceptibility to Streptococcus pneumoniae infection in patients with systemic lupus erythematosus is probably a multifactorial phenomenon. We report a case of a patient, a 36-year-old Caucasian female with 8-year history of systemic lupus erythematosus who presented a fatal Streptococcus pneumoniae necrotizing fasciitis. The role of computed tomography and the high performance of blood cultures for isolation of the causative microorganism are emphasized. Once diagnosis is suspected, empiric antibiotic treatment must be prescribed and prompt surgical exploration is mandatory. © The Author(s) 2015.

Phylogenetic relationships of Chilean leptodactylids: a molecular approach based on mitochondrial genes 12S and 16S Relaciones filogenéticas de los leptodactílidos chilenos: una aproximación molecular basada en los genes mitocondriales 12S y 16S

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CLAUDIO CORREA

2006-12-01

relationships recovered in this study suggest a multiple origin for Chilean temperate forest frogs and reveal an unexpected level of taxonomic diversity and evolutionary divergence among Chilean leptodactylidsLa mayoría de los anfibios chilenos pertenece a la subfamilia Telmatobiinae (Anura, Leptodactylidae. Varios estudios filogenéticos de Leptodactylidae y Telmatobiinae, basados principalmente en caracteres morfológicos, han sugerido implícitamente relaciones más estrechas de algunas especies de Telmatobiinae con miembros de otras subfamilias de leptodactílidos, incluyendo el género leptodactilino Pleurodema presente en Chile. Además, un número creciente de estudios moleculares sugieren un estatus no monofilético para Telmatobiinae, aunque ninguno de estos estudios ha investigado las relaciones filogenéticas de esta subfamilia. Secuencias parciales de los genes ribosomales mitocondriales 12S y 16S fueron comparadas para determinar las relaciones filogenéticas de los leptodactílidos chilenos y su posición dentro de los anuros modernos (Neobatrachia. Se incluyeron 22 especies de nueve de los diez géneros de telmatobinos presentes en Chile (Alsodes, Atelognathus, Batrachyla, Caudiverbera, Eupsophus, Hylorina, Insuetophrynus, Telmatobufo y Telmatobius, dos especies del género Pleurodema y una especie de Rhinodermatidae la cual es considerada una familia derivada de los leptodactílidos por algunos autores. Se incluyeron además 51 especies que representan la mayoría de las familias que componen Neobatrachia. Las reconstrucciones filogenéticas se realizaron utilizando los métodos de máxima parsimonia, máxima verosimilitud e inferencia bayesiana. Las topologías obtenidas en todos los análisis indican que Telmatobiinae es un ensamblaje polifilético, compuesto por especies que pertenecen a Hyloidea (la mayoría de los géneros y especies más relacionadas con taxa de Australasia (el clado Caudiverbera + Telmatobufo, definido como la tribu Calyptocephalellini

Cutaneous Manifestations of Systemic Lupus Erythematosus

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Uva, Luís; Miguel, Diana; Pinheiro, Catarina; Freitas, João Pedro; Marques Gomes, Manuel; Filipe, Paulo

2012-01-01

Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. The skin is one of the target organs most variably affected by the disease. The American College of Rheumatology (ACR) established 11 criteria as a classificatory instrument to operationalise the definition of SLE in clinical trials. They were not intended to be used to diagnose individuals and do not do well in that capacity. Cutaneous lesions account for four of these 11 revised criteria of SLE. Skin lesions in patients with lupus may be specific or nonspecific. This paper covers the SLE-specific cutaneous changes: malar rash, discoid rash, photosensitivity, and oral mucosal lesions as well as SLE nonspecific skin manifestations, their pathophysiology, and management. A deeper thorough understanding of the cutaneous manifestations of SLE is essential for diagnosis, prognosis, and efficient management. Thus, dermatologists should cooperate with other specialties to provide optimal care of SLE patient. PMID:22888407

Juvenile idiopathic arthritis in a patient with previous diagnosis of severe congenital lupus

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Rotstein Grein, I. H.; Armbrust, W.; van der Molen, A. M.; van Royen-Kerkhof, A.

Neonatal lupus (NL) is an acquired autoimmune disease of the newborn, caused by transplacental passage of the maternal autoantibodies anti SS-A/Ro and anti SS-B/La. When the clinical picture starts directly at birth, it is known as congenital lupus (CL). The clinical manifestations are variable.

THE SPITZER SURVEY OF INTERSTELLAR CLOUDS IN THE GOULD BELT. IV. LUPUS V AND VI OBSERVED WITH IRAC AND MIPS

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Spezzi, Loredana; Vernazza, Pierre; Merin, Bruno; Allen, Lori E.; Evans, Neal J. II; Harvey, Paul M.; Joergensen, Jes K.; Bourke, Tyler L.; Peterson, Dawn; Cieza, Lucas A.; Dunham, Michael M.; Huard, Tracy L.; Tothill, Nick F. H.

2011-01-01

We present Gould's Belt (GB) Spitzer IRAC and MIPS observations of the Lupus V and VI clouds and discuss them in combination with near-infrared (2MASS) data. Our observations complement those obtained for other Lupus clouds within the frame of the Spitzer C ore to Disk(c2d) Legacy Survey. We found 43 young stellar object (YSO) candidates in Lupus V and 45 in Lupus VI, including two transition disks, using the standard c2d/GB selection method. None of these sources was classified as a pre-main-sequence star from previous optical, near-IR, and X-ray surveys. A large majority of these YSO candidates appear to be surrounded by thin disks (Class III; ∼79% in Lupus V and ∼87% in Lupus VI). These Class III abundances differ significantly from those observed for the other Lupus clouds and c2d/GB surveyed star-forming regions, where objects with optically thick disks (Class II) dominate the young population. We investigate various scenarios that can explain this discrepancy. In particular, we show that disk photoevaporation due to nearby OB stars is not responsible for the high fraction of Class III objects. The gas surface densities measured for Lupus V and VI lie below the star formation threshold (A V ∼ 8.6 mag), while this is not the case for other Lupus clouds. Thus, few Myr older age for the YSOs in Lupus V and VI with respect to other Lupus clouds is the most likely explanation of the high fraction of Class III objects in these clouds, while a higher characteristic stellar mass might be a contributing factor. Better constraints on the age and binary fraction of the Lupus clouds might solve the puzzle but require further observations.

Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus: a cross-sectional study.

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Checa, A; Idborg, H; Zandian, A; Sar, D Garcia; Surowiec, I; Trygg, J; Svenungsson, E; Jakobsson, P-J; Nilsson, P; Gunnarsson, I; Wheelock, C E

2017-09-01

Objective The objective of this study was to investigate the association of clinical and renal disease activity with circulating sphingolipids in patients with systemic lupus erythematosus. Methods We used liquid chromatography tandem mass spectrometry to measure the levels of 27 sphingolipids in plasma from 107 female systemic lupus erythematosus patients and 23 controls selected using a design of experiment approach. We investigated the associations between sphingolipids and two disease activity indices, the Systemic Lupus Activity Measurement and the Systemic Lupus Erythematosus Disease Activity Index. Damage was scored according to the Systemic Lupus International Collaborating Clinics damage index. Renal activity was evaluated with the British Island Lupus Activity Group index. The effects of immunosuppressive treatment on sphingolipid levels were evaluated before and after treatment in 22 female systemic lupus erythematosus patients with active disease. Results Circulating sphingolipids from the ceramide and hexosylceramide families were increased, and sphingoid bases were decreased, in systemic lupus erythematosus patients compared to controls. The ratio of C 16:0 -ceramide to sphingosine-1-phosphate was the best discriminator between patients and controls, with an area under the receiver-operating curve of 0.77. The C 16:0 -ceramide to sphingosine-1-phosphate ratio was associated with ongoing disease activity according to the Systemic Lupus Activity Measurement and the Systemic Lupus Erythematosus Disease Activity Index, but not with accumulated damage according to the Systemic Lupus International Collaborating Clinics Damage Index. Levels of C 16:0 - and C 24:1 -hexosylceramides were able to discriminate patients with current versus inactive/no renal involvement. All dysregulated sphingolipids were normalized after immunosuppressive treatment. Conclusion We provide evidence that sphingolipids are dysregulated in systemic lupus erythematosus and associated

Isolated Tricuspid Valve Libman-Sacks Endocarditis in Systemic Lupus Erythematosus with Secondary Antiphospholipid Syndrome.

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Unic, Daniel; Planinc, Mislav; Baric, Davor; Rudez, Igor; Blazekovic, Robert; Senjug, Petar; Sutlic, Zeljko

2017-04-01

Libman-Sacks endocarditis, one of the most prevalent cardiac presentations of systemic lupus erythematosus, typically affects the aortic or mitral valve; tricuspid valve involvement is highly unusual. Secondary antiphospholipid syndrome increases the frequency and severity of cardiac valvular disease in systemic lupus erythematosus. We present the case of a 47-year-old woman with lupus and antiphospholipid syndrome whose massive tricuspid regurgitation was caused by Libman-Sacks endocarditis isolated to the tricuspid valve. In addition, we discuss this rare case in the context of the relevant medical literature.

Comparison of the Sensitivity to Change of the 36-Item Short Form Health Survey and the Lupus Quality of Life Measure Using Various Definitions of Minimum Clinically Important Differences in Patients With Active Systemic Lupus Erythematosus.

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Nantes, Stephanie G; Strand, Vibeke; Su, Jiandong; Touma, Zahi

2018-01-01

The Medical Outcomes Study Short Form 36 (SF-36) and Lupus Quality of Life (LupusQoL) are health-related quality of life questionnaires used in systemic lupus erythematosus (SLE). We first determined the hypothesis-testing construct validity of the SF-36 and LupusQoL against disease activity in patients with active SLE and then compared the sensitivity to change of SF-36 and LupusQoL domains according to different definitions of minimum clinically important differences (MCIDs) for improvement and worsening in the current cohort. Seventy-eight clinically active SLE patients concurrently completed both questionnaires at their baseline and followup visits. Questionnaire domain scores were correlated with the SLE Disease Activity Index 2000 (SLEDAI-2K) and evaluated for floor/ceiling effects. The sensitivity to change of domains in each questionnaire was analyzed first, according to the various MCID definitions and, second, by clinically meaningful changes in disease activity. The magnitudes of change in each domain score between the baseline and followup visit were evaluated using standardized response means. In the 78 patients, the mean ± SD SLEDAI-2K scores were 9.7 ± 4.8 at baseline and 8.8 ± 5.1 at followup. SF-36/LupusQoL domain scores did not correlate with disease activity. The SF-36 showed floor effects, and ceiling effects were evident in both questionnaires. All domains of both questionnaires showed sensitivity to change over time. Specific domains that reflected worsening or improvement differed according to differing MCID definitions. In SLE patients with active disease, both the SF-36 and LupusQoL are sensitive to change, reflecting both improvement and worsening. More importantly, the LupusQoL SLE-specific domains (planning, burden to others, body image, and intimate relationships) were largely responsive to change. © 2017, American College of Rheumatology.

IRF4 Deficiency Abrogates Lupus Nephritis Despite Enhancing Systemic Cytokine Production

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Lech, Maciej; Weidenbusch, Marc; Kulkarni, Onkar P.; Ryu, Mi; Darisipudi, Murthy Narayana; Susanti, Heni Eka; Mittruecker, Hans-Willi; Mak, Tak W.

2011-01-01

The IFN-regulatory factors IRF1, IRF3, IRF5, and IRF7 modulate processes involved in the pathogenesis of systemic lupus and lupus nephritis, but the contribution of IRF4, which has multiple roles in innate and adaptive immunity, is unknown. To determine a putative pathogenic role of IRF4 in lupus, we crossed Irf4-deficient mice with autoimmune C57BL/6-(Fas)lpr mice. IRF4 deficiency associated with increased activation of antigen-presenting cells in C57BL/6-(Fas)lpr mice, resulting in a massive increase in plasma levels of TNF and IL-12p40, suggesting that IRF4 suppresses cytokine release in these mice. Nevertheless, IRF4 deficiency completely protected these mice from glomerulonephritis and lung disease. The mice were hypogammaglobulinemic and lacked antinuclear and anti-dsDNA autoantibodies, revealing the requirement of IRF4 for the maturation of plasma cells. As a consequence, Irf4-deficient C57BL/6-(Fas)lpr mice neither developed immune complex disease nor glomerular activation of complement. In addition, lack of IRF4 impaired the maturation of Th17 effector T cells and reduced plasma levels of IL-17 and IL-21, which are cytokines known to contribute to autoimmune tissue injury. In summary, IRF4 deficiency enhances systemic inflammation and the activation of antigen-presenting cells but also prevents the maturation of plasma cells and effector T cells. Because these adaptive immune effectors are essential for the evolution of lupus nephritis, we conclude that IRF4 promotes the development of lupus nephritis despite suppressing antigen-presenting cells. PMID:21742731

The renal metallothionein expression profile is altered in human lupus nephritis

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Faurschou, Mikkel; Penkowa, Milena; Andersen, Claus Bøgelund

2008-01-01

of standard statistical methods. RESULTS: Proximal tubules displaying epithelial cell MT-I+II depletion in combination with luminal MT-I+II expression were observed in 31 out of 37 of the lupus nephritis specimens, but not in any of the control sections (P = 0.006). The tubular MT score, defined as the median......INTRODUCTION: Metallothionein (MT) isoforms I + II are polypeptides with potent antioxidative and anti-inflammatory properties. In healthy kidneys, MT-I+II have been described as intracellular proteins of proximal tubular cells. The aim of the present study was to investigate whether the renal MT......-I+II expression profile is altered during lupus nephritis. METHODS: Immunohistochemistry was performed on renal biopsies from 37 patients with lupus nephritis. Four specimens of healthy renal tissue served as controls. Clinicopathological correlation studies and renal survival analyses were performed by means...

Pregnancies in women with systemic lupus erythematosus and antiphospholipid antibodies

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Schreiber, K

2016-01-01

Systemic lupus erythematosus (SLE) has preponderance in women in their childbearing years; consequently pregnancy has always been an important issue of concern for the patient and the treating physician. Based upon numerous reports on successful pregnancy outcomes in the past decades, the initial...... of Pregnancy Outcome: Biomarkers in Antiphospholipid Antibody Syndrome and Systemic Lupus Erythematosus (PROMISSE) study, so far the largest multicentre cohort study of pregnant women with underlying stable SLE, has given some important answers to long-discussed questions. Future studies on data collected from...

El intento de neo-regalismo en el siglo XX: los proyectos de concordato entre Chile y la Santa Sede en 1928

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Salinas Areneda, Carlos

2014-04-01

Full Text Available La separación entre la Iglesia y el Estado de Chile llevada adelante por la Constitución de 1925 fue ocasión para que se hablara de un posible concordato entre Chile y la Santa Sede, siendo el gobierno chileno el que pretendió llevar a la práctica esa idea proponiendo textos concretos de concordato. En ellos, sin embargo, pretendió recuperar, por la vía de un pacto con la Santa Sede, viejas prácticas regalistas que con la separación entre la Iglesia y el Estado habían quedado derogadas pero que se resistía perder. En este artículo, a partir de materiales recientemente conocidos en el Archivo Secreto Vaticano, se estudian las cláusulas que en los proyectos redactados en 1928 son expresión del neo regalismo del gobierno chileno

Aggressive periodontitis in a patient with chronic cutaneous lupus erythematosus: a case report.

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Tietmann, Christina; Bissada, Nabil F

2006-05-01

Lupus erythematosus is considered to be a high risk factor for periodontitis. As an autoimmune disease of unknown origin, cutaneous lupus erythematosus (CLE) is subdivided into 3 categories: chronic (CCLE), subacute (SCLE), and acute (ACLE). While the ACLE has a high prevalence of conjunctive periodontal lesions, aggressive periodontitis in patients with CCLE has been rarely reported. This article describes the case of a patient diagnosed with aggressive periodontitis. Three months after the diagnosis of periodontitis, the patient experienced advancing hair loss (alopecia), pale fingers and toes, as well as edema in the legs and around the eyes. Skin biopsy showed follicular hyperkeratosis with perivascular mononuclear cell infiltrate. Colliquation of the basal cells, thickening of the basal lamina, and vacuolar degeneration of basal keratinocytes were also found. A lupus band test was positive, and diagnosis of CCLE was established. Three months following the treatment of lupus with antimalarial agents, the periodontal condition became stable with no further exacerbation or progression of the existing periodontitis. An 11-month postsurgical follow-up revealed stable periodontal and general medical conditions. A patient's medical history should be re-evaluated in the event of recurrence of periodontal lesions refractory to periodontal treatment. The control of systemic conditions like lupus erythematosus is essential for a good prognosis in the treatment of periodontitis as well as for the general health of the patient.

Anti-pentraxin 3 auto-antibodies might be protective in lupus nephritis: a large cohort study.

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Yuan, Mo; Tan, Ying; Pang, Yun; Li, Yong-Zhe; Song, Yan; Yu, Feng; Zhao, Ming-Hui

2017-11-01

Anti-pentraxin 3 (PTX3) auto-antibodies were found to be associated with the absence of renal involvement in systemic lupus erythematosus (SLE). This study is to investigate the prevalence of anti-PTX3 auto-antibodies and their clinical significance based on a large Chinese lupus nephritis cohort. One hundred and ninety-six active lupus nephritis patients, 150 SLE patients without clinical renal involvement, and 100 healthy controls were enrolled. Serum anti-PTX3 auto-antibodies and PTX3 levels were screened by enzyme-linked immunosorbent assay (ELISA). The associations between anti-PTX3 auto-antibodies and clinicopathological parameters in lupus nephritis were further analyzed. Anti-PTX3 auto-antibodies were less prevalent in active lupus nephritis patients compared with SLE without renal involvement (19.4% (38/196) versus 40.7% (61/150), p auto-antibodies were negatively correlated with proteinuria in lupus nephritis (r = -.143, p = .047). The levels of proteinuria, serum creatinine, and the prevalence of thrombotic microangiopathy were significantly higher in patients with higher PTX3 levels (≥3.207 ng/ml) and without anti-PTX3 auto-antibodies compared with patients with lower PTX3 levels (auto-antibodies (4.79 (3.39-8.28) versus 3.95 (1.78-7.0), p = .03; 168.84 ± 153.63 versus 101.44 ± 47.36, p = .01; 34.1% (14/41) versus 0% (0/9), p = .04; respectively). Anti-PTX3 auto-antibodies were less prevalent in active lupus nephritis patients compared with SLE without renal involvement and associated with less severe renal damage, especially with the combined evaluation of serum PTX3 levels.

Cognitive functions and autoantibodies in patients with systemic lupus erythematosus

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Anna Bogaczewicz

2016-06-01

Full Text Available Introduction: Autoantibodies may occur in the course of various diseases. In the case of systemic lupus erythematosus the presence of specific autoantibodies is included in the classification criteria of the disease. The aim of the study was to investigate whether the presence of the serologic markers of systemic lupus erythematosus, i.e. anti-dsDNA, anti-Sm and anticardiolipin antibodies of the class IgM and IgG are linked with the results of neuropsychological tests evaluating selected cognitive functions in patients without overt neuropsychiatric lupus and without antiphospholipid syndrome. Material and methods: The study included 22 patients with systemic lupus erythematosus. For the assessment of anti-dsDNA, anti-Sm and anticardiolipin antibodies the immunoenzymatic method was used. For neuropsychological estimation of the selected cognitive functions the attention switching test and the choice reaction time were applied, in which the results are expressed as the average delay i.e. mean correct latency, using the computer-based Cambridge Neuropsychological Test Automated Battery (CANTAB. Results: The results of attention switching test in patients with anti-Sm antibodies were lower, but not significantly different from those obtained by the patients without such antibodies: 75.0 (73.12–88.12 vs. 92.5 (85–95. Choice reaction time was significantly longer in patients with anti-Sm antibodies in comparison to the patients without antiSm antibodies: 614.9 (520.6–740.8 vs. 476.7 (396.6–540 (p = 0.01. No significant difference was demonstrated in the results of attention switching test and choice reaction time with regard to the presence of anti-dsDNA antibodies. The results of attention switching test and choice reaction time were not different between the groups of patients with and without anticardiolipin antibodies in the IgM and IgG class. Conclusions: Anti-Sm antibodies seem to contribute to

76 FR 81665 - Endangered and Threatened Wildlife and Plants; Revising the Listing of the Gray Wolf (Canis lupus...

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2011-12-28

... Wolf (Canis lupus) in the Western Great Lakes; Final rule #0;#0;Federal Register / Vol. 76, No. 249... (Canis lupus) in the Western Great Lakes AGENCY: Fish and Wildlife Service, Interior. ACTION: Final rule... Minnesota population of gray wolves (Canis lupus) to conform to current statutory and policy requirements...

Clinical and immunological characteristics of 150 systemic lupus erythematosus patients in Jamaica: a comparative analysis.

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Maloney, K C; Ferguson, T S; Stewart, H D; Myers, A A; De Ceulaer, K

2017-11-01

Background Epidemiological studies in systemic lupus erythematosus have been reported in the literature in many countries and ethnic groups. Although systemic lupus erythematosus in Jamaica has been described in the past, there has not been a detailed evaluation of systemic lupus erythematosus patients in urban Jamaica, a largely Afro-Caribbean population. The goal of this study was to describe the clinical features, particularly disease activity, damage index and immunological features, of 150 systemic lupus erythematosus subjects. Methods 150 adult patients (≥18 years) followed in rheumatology clinic at a tertiary rheumatology hospital centre (one of two of the major public referral centres in Jamaica) and the private rheumatology offices in urban Jamaica who fulfilled Systemic Lupus International Collaborating Clinics (SLICC) criteria were included. Data were collected by detailed clinical interview and examination and laboratory investigations. Hence demographics, SLICC criteria, immunological profile, systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K) and SLICC/American College of Rheumatology (ACR) damage index (SDI) were documented. Results Of the 150 patients, 145 (96.7%) were female and five (3.3%) were male. The mean age at systemic lupus erythematosus onset was 33.2 ± 10.9. Mean disease duration was 11.3 ± 8.6 years. The most prevalent clinical SLICC criteria were musculoskeletal, with 141 (94%) of subjects experiencing arthralgia/arthritis, followed by mucocutaneous manifestations of alopecia 103 (68.7%) and malar rash 46 (30.7%), discoid rash 45 (30%) and photosensitivity 40 (26.7%). Lupus nephritis (biopsy proven) occurred in 42 (28%) subjects and 25 (16.7%) met SLICC diagnostic criteria with only positive antinuclear antibodies/dsDNA antibodies and lupus nephritis on renal biopsy. The most common laboratory SLICC criteria were positive antinuclear antibodies 136 (90.7%) followed by anti-dsDNA antibodies 95 (63.3%) and

Systemic Lupus Erythematosus Presenting as Acute Adrenal ...

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hanumantp

presented to us with a history of anorexia, progressive darkening of the face ... to us in an acute hypoadrenal state and was found to have Systemic lupus erythematosus with renal involvement. .... Textbook of Endocrinology. 11th ed. Saunders: ...

Coincident systemic lupus erythematosus and psoriasis vulgaris: a case report.

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Wang, Y; Da, G; Yu, Y; Han, J; Li, H

2015-12-01

Psoriasis vulgaris is an autoimmune chronic inflammatory skin disease, but its association with other typical autoimmune disease such as systemic lupus erythematosus has only occasionally been reported. We presented a 25-year-old female who developed systemic lupus erythematosus associated with psoriasis vulgaris. Her conditions were in good control after she got administration of prednisolone (5 mg/day) and Tripterygium Wilfordii Hook (20 mg/day). It is necessary to integrate past history and physical examination to diagnose coincident SLE and psoriasis, and combined treatment with prednisolone and Tripterygium Wilfordii Hook proves effective.

Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus;

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Ferreira, Isabel; Croca, Sara; Raimondo, Maria Gabriella

2017-01-01

BACKGROUND: In patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small...... number of patients with NPSLE. Here we measured serum NN in samples from a larger population of patients with SLE and NP events to see whether elevated serum NN could be a marker for NPSLE. METHODS: We obtained serum samples from patients in the Systemic Lupus International Collaborative Clinics (SLICC...

Desafíos de una práctica ético-política. El trabajo social chileno post-dictadura

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Luís Vivero Arriagada

2017-10-01

Full Text Available El supuesto que se plantea para este trabajo sostiene que el Trabajo Social se ha visto dominada por la lógica mercantilista del neoliberalismo, impuesta durante la dictadura cívico-militar en Chile. Desde una perspectiva hermenéutica-crítica se analizan e interpretan los antecedentes históricos del Trabajo Social chileno. Se concluye que la formación y la práctica de la disciplina requieren de una re-orientación, que debe partir de una profunda reflexión histórica crítica y a partir de ello, generar las bases del nuevo proyecto ético- político que oriente el quehacer disciplinario y profesional.

Gastrointestinal symptomatology as first manifestation of systemic erythematous lupus

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Kovačević Zoran

2009-01-01

Full Text Available Background. Systemic lupus erithematodes (SLE is chronic, often febrile, multisystemic disease unknown origin and relapsing course which affects connective tissue of the skin, joints, kidney and serous membranes. Gastrointestinal manifestations are rarely the first sign of systemic lupus erythematosus. Case report. We presented a female patient, 35 years old, whose first symptoms of SLE were paralitic ileus (chronic intestinal pseudo-obstruction and polyserositis (pleural effusion and ascites. Except for high parameters of inflammation, leucopenia and thrombocytopenia, all immunological and laboratory tests for SLE were negative in the onset of the disease. During next six months the patient had clinical signs of paralitic ileus several times and was twice operated with progressive malabsorptive syndrome. The full picture of SLE was manifested seven months later associated with lupus nephritis. Treatment with cyclophosphamide, corticosteroids and total parenteral nutrition (30 days induced stable remission of the disease. Conclusion. The SLE can be initially manifested with gastroenterological symptoms without any other clinical and immunologic parameters of the disease. If in patients with SLE and gastrointestinal tract involvement malabsorption syndrom is developed, a treatment success depends on both immunosupressive therapy and total parenteral nutrition.

Plasma ficolin levels and risk of nephritis in Danish patients with systemic lupus erythematosus

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Tanha, Nima; Pilely, Katrine; Faurschou, Mikkel

2017-01-01

Given the scavenging properties of ficolins, we hypothesized that variation in the plasma concentrations of the three ficolins may be associated with development of lupus nephritis (LN), type of LN, end-stage renal disease (ESRD), and/or mortality among patients with systemic lupus erythematosus...

Treat-to-target in systemic lupus erythematosus

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van Vollenhoven, Ronald F; Mosca, Marta; Bertsias, George

2014-01-01

guidance for healthcare providers and administrators. Thus, an initiative to evaluate possible therapeutic targets and develop treat-to-target guidance was believed to be highly appropriate in the management of systemic lupus erythematosus (SLE) patients as well. Specialists in rheumatology, nephrology...

The frequency and outcome of lupus nephritis

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Hanly, John G; O'Keeffe, Aidan G; Su, Li

2016-01-01

OBJECTIVE: To determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort. METHODS: Patients in the Systemic Lupus International Collaborating Clinics inception cohort (≤15 months of SLE diagnosis) were assessed annually for estimated glomerular filtration rate (e...

Tumid Lupus Erythematosus: An Intriguing Dermatopathological Connotation Treated Successfully with Topical Tacrolimus and Hydroxyxhloroquine Combination

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Verma, Prashant; Sharma, Sonal; Yadav, Pravesh; Namdeo, Chaitanya; Mahajan, Garima

2014-01-01

Tumid lupus erythematosus (LE) is a rare variant of lupus erythematosus, which often follows a favorable course. A case of a young woman is illustrated, who presented with an asymptomatic erythematous, solitary plaque over her face. Histopathological and direct immunofluorescence examination established a diagnosis of tumid lupus erythematosus. She responded slowly and near-completely to hydroxychloroquine sulfate; however, a flare up occurred a month later. Addition of topical tacrolimus 0.1% resulted in complete regression without leaving any residual changes. No recurrence was seen subsequently. PMID:24700961

Nuevas Tendencias del Cine Chileno tras la llegada del Cine Digital New Tendencies in Chilean Contemporary Cinema After the Implosion Of Digital Video

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Carolina Larraín Pulido

2010-07-01

Full Text Available La llegada de tecnologías digitales al país en pocos años transforma la escena de producción cinematográfica, no sólo modificando los costos y procesos implicados en la cadena de producción y exhibición cinematográfica, sino también posibilitando la gestación de una escena de producción de largometrajes digitales de bajo costo, que permite el surgimiento de una serie de nuevos realizadores, temáticas, estilos, formas de producción y circuitos de exhibición. El artículo Nuevas Tendencias del cine chileno tras la llegada del cine digital explora e intenta dar cuenta de este fenómeno reciente en el medio chileno, dando cuenta de cómo la inserción de la tecnología digital ha impactado sobre estas nuevas cinematografías, revisando nuevos usos, prácticas, representaciones y tendencias presentes en estas realizaciones.Abstract During the past years, the insertion of digital technologies in Chile has greatly affected the nation's film scenario, not only modifying the chain of film production and exhibition, but also generating a production scene of low-budget digital feature film that has allowed the development of new directors, themes, styles and modes of production and exhibition. The present article analyzes this recent phenomenon in Chilean film industry, revising how the insertion of digital technologies has affected these new forms of cinema in terms of style, production practices, exhibition, purposes and main tendencies.

Redes sociales, acción colectiva y elecciones: los usos de Facebook por el movimiento estudiantil chileno durante la campaña electoral de 2013

OpenAIRE

Lázaro M. Bacallao-Pino

2016-01-01

Los estudios recientes sobre las redes sociales digitales han analizado, por un lado, sus usos como parte de la acción colectiva y, por otro, sus usos durante las campañas electorales. Basado en el estudio del movimiento estudiantil chileno durante la campaña electoral de 2013 en ese país, el texto analiza los usos de Facebook por parte de tres federaciones estudiantiles que integran dicho movimiento. Los resultados indican que se priorizan las dimensiones informativa y organizativa en los us...

Radiographic findings of systemic lupus erythematosus enteritis (a report of 4 cases)

International Nuclear Information System (INIS)

Zhang Ailian; Li Ruilan; Gao Yu'ao

1999-01-01

Objective: To discuss the radiographic findings and diagnosis in lupus enteritis. Methods: 4 cases of lupus enteritis (male 1, female 3) were studied. Abdominal pain was the chief complaint in all these cases. Before and after steroid therapy, small bowel contrast study was performed. Results: In one patient abdominal plain film revealed slight dilatation of jejunum with air-fluid levels. Small bowel contrast study showed effacement and (or) nodules of the mucosal folds, thumb printing, spasm and some degree of rigidity and narrowing of the lumen. Clinical symptoms and radiographic findings became normal after steroid therapy. Conclusions: If a patient with systemic lupus erythematosus presents abdominal symptoms, small bowel contrast study should be done. It is important and helpful to assist the diagnosis, to decide therapeutic plan and to follow up the effect of treatment

Age-related changes in Serum Growth Hormone, Insulin-like Growth Factor-1 and Somatostatin in System Lupus Erythematosus

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Malemud Charles J

2004-10-01

Full Text Available Abstract Background Systemic lupus erythematosus is an age- and gender-associated autoimmune disorder. Previous studies suggested that defects in the hypothalamic/pituitary axis contributed to systemic lupus erythematosus disease progression which could also involve growth hormone, insulin-like growth factor-1 and somatostatin function. This study was designed to compare basal serum growth hormone, insulin-like growth factor-1 and somatostatin levels in female systemic lupus erythematosus patients to a group of normal female subjects. Methods Basal serum growth hormone, insulin-like growth factor-1 and somatostatin levels were measured by standard radioimmunoassay. Results Serum growth hormone levels failed to correlate with age (r2 = 3.03 in the entire group of normal subjects (i.e. 20 – 80 years. In contrast, serum insulin-like growth factor-1 levels were inversely correlated with age (adjusted r2 = 0.092. Of note, serum growth hormone was positively correlated with age (adjusted r2 = 0.269 in the 20 – 46 year range which overlapped with the age range of patients in the systemic lupus erythematosus group. In that regard, serum growth hormone levels were not significantly higher compared to either the entire group of normal subjects (20 – 80 yrs or to normal subjects age-matched to the systemic lupus erythematosus patients. Serum insulin-like growth factor-1 levels were significantly elevated (p 55 yrs systemic lupus erythematosus patients. Conclusions These results indicated that systemic lupus erythematosus was not characterized by a modulation of the growth hormone/insulin-like growth factor-1 paracrine axis when serum samples from systemic lupus erythematosus patients were compared to age- matched normal female subjects. These results in systemic lupus erythematosus differ from those previously reported in other musculoskeletal disorders such as rheumatoid arthritis, osteoarthritis, fibromyalgia, diffuse idiopathic skeletal

Trombocitopenia de difícil manejo en niño preescolar con LES: Reporte de un caso

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Mario Nicolás Albani Pérez

2010-08-01

Full Text Available El lupus eritematoso sistémico (LES es una enfermedad autoinmune del tejido conectivo, infrecuente en el sexo masculino y durante la infancia. La trombocitopenia se presenta en 15% de los casos de LES, y como forma de inicio es poco común. Se reporta el caso de preescolar masculino de 3 años de edad con inicio de enfermedad a los 18 meses de edad que presentó diarrea, rash cutáneo, equimosis y trombocitopenia; ameritando transfusión de concentrado plaquetario obteniendo mejoría parcial y en control con hematólogo. A los  2 años de edad reaparece equimosis y se diagnostica Púrpura Trombocitopénica Idiopática, tratado con inmunoglobulinas y esteroides sin respuesta satisfactoria. Es referido a Inmunología donde solicitan estudios y los resultados son compatibles con LES, por lo cual recibió prednisona sin respuesta satisfactoria. En Febrero de 2009, presenta epistaxis requiriendo hospitalización y tratamiento con inmunoglobulinas. En Mayo de 2009, presenta otorragia derecha ameritando nuevamente hospitalización y tratamiento con inmunoglobulinas. Se emplea Danazol con buena respuesta. En caso que en el futuro no ofrezca mejoría, se plantea el uso alternativo de ciclosporinas o anticuerpos monoclonales Anti-CD20 (Rituximab dejando como último recurso la esplenectomía. Se presenta el caso clínico considerando la importancia con respecto a la edad de presentación y el manejo no convencional que se debió adoptar para tratar al paciente.

Trombocitopenia de difícil manejo en niño preescolar con LES: Reporte de un caso

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Mario Nicolás Albani Pérez

2009-01-01

Full Text Available El lupus eritematoso sistémico (LES es una enfermedad autoinmune del tejido conectivo, infrecuente en el sexo masculino y durante la infancia. La trombocitopenia se presenta en 15% de los casos de LES, y como forma de inicio es poco común. Se reporta el caso de preescolar masculino de 3 años de edad con inicio de enfermedad a los 18 meses de edad que presentó diarrea, rash cutáneo, equimosis y trombocitopenia, ameritando transfusión de concentrado plaquetario obteniendo mejoría parcial y en control con hematólogo. A los 2 años de edad reaparece equimosis y se diagnostica Púrpura Trombocitopénica Idiopática, tratado con inmunoglobulinas y esteroides sin respuesta satisfactoria. Es referido a Inmunología donde solicitan estudios y los resultados son compatibles con LES, por lo cual recibió prednisona sin respuesta satisfactoria. En Febrero de 2009, presenta epistaxis requiriendo hospitalización y tratamiento con inmunoglobulinas. En Mayo de 2009, presenta otorragia derecha ameritando nuevamente hospitalización y tratamiento con inmunoglobulinas. Se emplea Danazol con buena respuesta. En caso que en el futuro no ofrezca mejoría, se plantea el uso alternativo de ciclosporinas o anticuerpos monoclonales Anti- CD20 (Rituximab dejando como último recurso la esplenectomía. Se presenta el caso clínico considerando la importancia con respecto a la edad de presentación y el manejo no convencional que se debió adoptar para tratar al paciente.

A case of mistaken identity: When lupus masquerades as primary myelofibrosis

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Edy Hasrouni

2013-08-01

Full Text Available Introduction: Autoimmune myelofibrosis is an uncommon hematologic disease characterized by anemia, bone marrow myelofibrosis, and an autoimmune feature. Myelofibrosis is often associated with other conditions, including infections, nutritional/endocrine dysfunction, toxin/drug exposure, and connective tissue diseases, including scleroderma and systemic lupus erythematosus. Absence of clonal markers ( JAK2 and heterogeneity of the symptoms often complicate the diagnosis. Case presentation: Here, we present two cases of systemic lupus erythematosus–induced autoimmune myelofibrosis. The first case is of a 36-year-old African American female with diagnosis of systemic lupus erythematosus at the age of 12 years. The second patient is a 44-year-old African American male with family history of systemic lupus erythematosus who developed anemia and constitutional symptoms later on. Both patients showed hypercellularity and fibrotic changes of the bone marrow. Moreover, mutational analysis showed that both patients were wild type for JAK2 (V617F and exon 12 and MPL (exon 10. Conclusions: These two cases illustrate that anemic patients with fibrotic changes in the bone marrow without other clinicopathologic features associated with primary myelofibrosis in the presence of clinical manifestations and history of an autoimmune disease should suggest an autoimmune myelofibrosis. These cases demonstrate that a good clinical history combined with molecular technologies and pathomorphologic criteria are helpful in distinguishing between primary myelofibrosis and a nonclonal myelofibrosis from an associated condition.

Discoid lupus erythematosus exacerbated by X-ray irradiation

Energy Technology Data Exchange (ETDEWEB)

Eedy, D J; Corbett, J R

1988-05-01

The authors describe a patient, previously known to have discoid lupus erythematosus (LE) developing a LE rash in the precise distribution of radiation therapy given for the treatment of a bronchogenic neoplasm.

Prevalence of Lupus Anticoagulant in Women with Spontaneous ...

African Journals Online (AJOL)

2017-10-26

Oct 26, 2017 ... ... pregnancy. Presence of lupus anticoagulant (LA), one of the antiphospholipid antibodies, ... pregnancy outcomes such as preeclampsia/eclampsia and small for date deliveries. ... changes in a background of APL syndrome.

Frequency and Type of Hepatic and Gastrointestinal Involvement in Juvenile Systemic Lupus Erythematosus

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Leila Tahernia

2017-01-01

Full Text Available Background. Systemic lupus erythematosus (SLE is a frequent rheumatology disorder among children. Since hepatic involvement is a common systemic manifestation in lupus, the frequency and type of hepatic involvement were determined in pediatric cases of SLE admitted to Children’s Medical Hospital from 2005 to 2014. Methods and Patients. In this observational case-series study, 138 pediatric cases of SLE were admitted in Children’s Medical Center (a pediatric rheumatology referral center in Tehran, Iran enrolled from 2005 to 2014 and the outcomes, frequency, and type of hepatic involvement were assessed among them. Results. Hepatic involvement was reported in 48.55% of total SLE patients. Aspartate aminotransferase (AST, alanine aminotransferase (ALT, and both enzymes higher than normal upper limits were detected in 8.7%, 5%, and 34.7% of lupus patients, respectively. Increased level of liver enzymes was categorized as less than 100, between 100 and 1000, and more than 1000 levels in 23.1%, 23.1%, and 2.1% of cases. The only gastrointestinal involvement in lupus patients contributing to hepatic involvement was gastrointestinal bleeding. Rising in liver enzymes was detected mostly in lupus patients without gastrointestinal bleeding (52.2% without versus 25.8% with gastrointestinal bleeding, P=0.007. Conclusion. Approximately half of the pediatric patients suffering from SLE have hepatic involvement. No significant correlation was observed between various organs involvement and abnormal level of liver enzymes.

Tumid lupus erythematosus: An intriguing dermatopathological connotation treated successfully with topical tacrolimus and hydroxyxhloroquine combination

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Prashant Verma

2014-01-01

Full Text Available Tumid lupus erythematosus (LE is a rare variant of lupus erythematosus, which often follows a favorable course. A case of a young woman is illustrated, who presented with an asymptomatic erythematous, solitary plaque over her face. Histopathological and direct immunofluorescence examination established a diagnosis of tumid lupus erythematosus. She responded slowly and near-completely to hydroxychloroquine sulfate; however, a flare up occurred a month later. Addition of topical tacrolimus 0.1% resulted in complete regression without leaving any residual changes. No recurrence was seen subsequently.

Discoid lupus erythematosus exacerbated by X-ray irradiation

International Nuclear Information System (INIS)

Eedy, D.J.; Corbett, J.R.

1988-01-01

The authors describe a patient, previously known to have discoid lupus erythematosus (LE) developing a LE rash in the precise distribution of radiation therapy given for the treatment of a bronchogenic neoplasm. (author)

Treatment Algorithms in Systemic Lupus Erythematosus.

Science.gov (United States)

Muangchan, Chayawee; van Vollenhoven, Ronald F; Bernatsky, Sasha R; Smith, C Douglas; Hudson, Marie; Inanç, Murat; Rothfield, Naomi F; Nash, Peter T; Furie, Richard A; Senécal, Jean-Luc; Chandran, Vinod; Burgos-Vargas, Ruben; Ramsey-Goldman, Rosalind; Pope, Janet E

2015-09-01

To establish agreement on systemic lupus erythematosus (SLE) treatment. SLE experts (n = 69) were e-mailed scenarios and indicated preferred treatments. Algorithms were constructed and agreement determined (≥50% respondents indicating ≥70% agreement). Initially, 54% (n = 37) responded suggesting treatment for scenarios; 13 experts rated agreement with scenarios. Fourteen of 16 scenarios had agreement as follows: discoid lupus: first-line therapy was topical agents and hydroxychloroquine and/or glucocorticoids then azathioprine and subsequently mycophenolate (mofetil); uncomplicated cutaneous vasculitis: initial treatment was glucocorticoids ± hydroxychloroquine ± methotrexate, followed by azathioprine or mycophenolate and then cyclophosphamide; arthritis: initial therapy was hydroxychloroquine and/or glucocorticoids, then methotrexate and subsequently rituximab; pericarditis: first-line therapy was nonsteroidal antiinflammatory drugs, then glucocorticoids with/without hydroxychloroquine, then azathioprine, mycophenolate, or methotrexate and finally belimumab or rituximab, and/or a pericardial window; interstitial lung disease/alveolitis: induction was glucocorticoids and mycophenolate or cyclophosphamide, then rituximab or intravenous gamma globulin (IVIG), and maintenance followed with azathioprine or mycophenolate; pulmonary hypertension: glucocorticoids and mycophenolate or cyclophosphamide and an endothelin receptor antagonist were initial therapies, subsequent treatments were phosphodiesterase-5 inhibitors and then prostanoids and rituximab; antiphospholipid antibody syndrome: standard anticoagulation with/without hydroxychloroquine, then a thrombin inhibitor for venous thrombosis, versus adding aspirin or platelet inhibition drugs for arterial events; mononeuritis multiplex and central nervous system vasculitis: first-line therapy was glucocorticoids and cyclophosphamide followed by maintenance with azathioprine or mycophenolate, and

Purtscher-like retinopathy in systemic lupus erythematosus.

Science.gov (United States)

Wu, Chan; Dai, Rongping; Dong, Fangtian; Wang, Qian

2014-12-01

To investigate clinical characteristics of Purtscher-like retinopathy and its clinical implications among patients with systemic lupus erythematosus (SLE). Observational case series. setting: Tertiary medical center. patient population: Patients with SLE who were diagnosed with Purtscher-like retinopathy between 2002 and 2013. observation procedures: Assessment and follow-up in the ophthalmology department. main outcome measure: Visual acuity and funduscopic examination at presentation and at 6 month follow-up, with analysis of the association between Purtscher-like retinopathy and other systemic involvement of SLE and overall disease activity. Among 5688 patients with SLE evaluated, 8 cases of Purtscher-like retinopathy were diagnosed. Typical fundus abnormalities included Purtscher flecken, cotton-wool spots, retinal hemorrhages, macular edema, optic disk swelling, and a pseudo-cherry red spot. Fluorescein angiography abnormalities included areas of capillary nonperfusion corresponding to the retinal whitening, late leakage, peripapillary staining, precapillary occlusion, and slower filling of vessels. The prevalence of central nervous system lupus was significantly higher among those with Purtscher-like retinopathy (6/8) than among 240 patients randomly sampled from those without Purtscher-like retinopathy. A very high SLE Disease Activity Index (≥20) was present in all 8 patients with Purtscher-like retinopathy. All patients received corticosteroids combined with immunosuppressants. For the majority of patients, optic atrophy developed during follow-up with persistent low visual acuity. As a rare and severe ophthalmic complication of SLE, Purtscher-like retinopathy was associated with central nervous system lupus and highly active disease. Visual acuity recovery was usually poor despite prompt treatment. Copyright © 2014 Elsevier Inc. All rights reserved.

Brain diffusion tensor MRI in systematic lupus erythematosus: A systematic review.

Science.gov (United States)

Costallat, Beatriz Lavras; Ferreira, Daniel Miranda; Lapa, Aline Tamires; Rittner, Letícia; Costallat, Lilian Tereza Lavras; Appenzeller, Simone

2018-01-01

Diffusion tensor imaging (DTI) maps the brain's microstructure by measuring fractional anisotropy (FA) and mean diffusivity (MD). This systematic review describes brain diffusion tensor Magnetic resonance imaging (MRI) studies in systemic lupus erythematosus (SLE).The literature was reviewed following the PRISMA guidelines and using the terms "lupus", "systemic lupus erythematosus", "SLE", "diffusion tensor imaging", "DTI", "white matter" (WM), "microstructural damage", "tractography", and "fractional anisotropy"; the search included articles published in English from January 2007 to April 2017. The subjects included in the study were selected according to the ACR criteria and included 195 SLE patients with neuropsychiatric manifestation (NPSLE), 299 without neuropsychiatric manifestation (non-NPSLE), and 423 healthy controls (HC). Most studies identified significantly reduced FA and increased MD values in several WM regions of both NPSLE and non-NPSLE patients compared to HC. Subclinical microstructural changes were observed in either regional areas or the entire brain in both the non-NPSLE and NPSLE groups. Copyright © 2017 Elsevier B.V. All rights reserved.

Associated Variables of Myositis in Systemic Lupus Erythematosus: A Cross-Sectional Study.

Science.gov (United States)

Liang, Yan; Leng, Rui-Xue; Pan, Hai-Feng; Ye, Dong-Qing

2017-05-26

BACKGROUND This study aimed to estimate the point prevalence of myositis and identify associated variables of myositis in systemic lupus erythematosus (SLE). MATERIAL AND METHODS Clinical date of patients hospitalized with lupus at the First Affiliated Hospital of Anhui Medical University and Anhui Provincial Hospital were collected. Patients were defined as having myositis if they reported the presence of persistent invalidating muscular weakness combined with increased levels of creatine phosphokinase (CPK) and abnormal electromyography (EMG). RESULTS The study sample comprised 1701 lupus patients, of which 44 had myositis. Patients with SLE-associated myositis are more likely to have skin rash, alopecia, pericarditis, vasculitis, anti-Sm, anti-RNP, anti-dsDNA, thrombocytopenia, leukopenia, low C3, low C4, high erythrocyte sedimentation rate (ESR), high D-dimer, and active disease. Multivariate logistic regression found positive associations between leukopenia, alopecia, and active disease with myositis. Negative associations between myositis with the use of corticosteroids or immunosuppressive drugs were revealed in univariate and multivariate analysis. CONCLUSIONS The point prevalence of myositis was 2.6% in SLE patients. The significant association of alopecia, leukopenia, and active disease with myositis suggests that organ damage, hematological abnormality, and high disease activity promote the progression of myositis in lupus patients.

Histological aspects of the bladder in systemic lupus erythematosus

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Eric Roger Wroclawski

2009-12-01

Full Text Available Objectives: to study pathological data from bladders of systemic lupus erythematosus patients, correlate them to clinical events and the use of therapeutic drugs, and compare them to bladder histopathological findings in individuals not affected by systemic lupus erythematosus. Methods: thirty-nine out or inpatients of the Department of Rheumatology at Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, diagnosed with systemic lupus erythematosus were clinically and cystoscopically evaluated. Bladder biopsy was also performed. As a normal parameter, bladders taken from 20 corpses collected at the Death Verification Department  of São Paulo city, without autolysis or evidence of urinary tract or autoimmune disease were also histologically studied. This group was considered as a Control Group. A correlation among clinical, cystoscopic and histopathological data was carried out. Rresults: the patients’ mean age was 29 years (range 13-62. Thirty-six were females and three were males. Twenty-five patients were asymptomatic during the study period. In the Control Group the age range was 20-65 years. Nineteen were females (95% and one was male (5%. Cystoscopic examination of the group with systemic lupus erythematosus showed interstitial pattern in 16 cases (41.0% and normal in 15 (38.5%. The bladder was normal in four patients (10.3%. Chronic unspecific cystitis was observed in 18 (46.2% patients. In the remaining, several alterations were found, including bladder vasculitis in seven patients (17.9%. The mean number of mast cells in the bladder area was 2.223/mm2. In the Control Group, unspecific cystitis was found in three cases (15.0%. No other abnormalities were found. The mean number of mast cells in this group was 0.777/mm2 (±2.7. Chronic unspecific cystitis, bladder vasculitis and the mean number of mast cells were compared with each other and no statistical differences were found (p > 0.05. There were

New developments in lupus-associated antiphospholipid syndrome

NARCIS (Netherlands)

Lockshin, M. D.; Derksen, R. H. W. M.

2008-01-01

Systemic lupus erythematosus is the disease in which the antiphospholipid syndrome was first described more than 20 years ago and which is the most frequent underlying disorder in secondary antiphospholipid syndrome. With respect to pathogenic concepts and treatment, the subjects of this review, no

Micromanagement of lupus autoimmunity by microRNAs

NARCIS (Netherlands)

Shen, N.

2012-01-01

De observaties die Nan Shen deed in zijn promotieonderzoek verschaffen nieuwe inzichten in het ontstaan van de auto-immuunziekte systemische lupus erythematodes (SLE). Ook dragen ze bij aan De observaties die Nan Shen deed in zijn promotieonderzoek verschaffen nieuwe inzichten in het ontstaan van de

How do women with lupus manage fatigue?

DEFF Research Database (Denmark)

Kier, Anne Ørnholt; Midtgaard, Julie; Hougaard, Karin Sørig

2016-01-01

Objective: Half of patients with systemic lupus erythematosus (SLE) consider fatigue to be the most disabling disease symptom. To develop and promote strategies to prevent and control fatigue, this study aimed to describe how women with SLE manage the experience of fatigue. Methods: Four focus...

La nueva estética del teatro chileno bajo el régimen militar. Una revisión de la práctica escénica neoexpresionista chilena en los años ochenta

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Sergio Pereira Poza

2014-06-01

Full Text Available Dentro de la reciente historia del teatro chileno hay un acontecimiento que no puede dejar de ser advertido como una de las señales más claras del cambio de perspectiva que empieza a gestarse en lo que llamaremos aquí el nuevo teatro chileno. Nos referimos a los hechos que rodearon al frustrado estreno de Lo crudo, lo cocido y lo podrido, del médico psiquiatra y dramaturgo Marco Antonio de la Parra en 1978. Al margen de la imagen no realista del mundo que entregaba la obra y, por lo mismo, ajena a los códigos artísticos dominantes, la dimensión grotesca de las diferentes escenas de Lo crudo, lo cocido y lo podrido aparecía ante los ojos de espectadores y lectores poco avisados como una burla que atentaba contra las venerables instituciones tradicionales del país y sus hombres. Ésta fue la lectura que hizo el entonces Vicerrector de Extensión de la Universidad Católica de Chile, Hernán Larraín.

Off-label use of rituximab for systemic lupus erythematosus in Europe

DEFF Research Database (Denmark)

Ryden-Aulin, Monica; Boumpas, Dimitrios T; Bultink, Irene

2016-01-01

Objectives: Rituximab (RTX) is a biological treatment used off-label in patients with systemic lupus erythematosus (SLE). This survey aimed to investigate the off-label use of RTX in Europe and compare the characteristics of patients receiving RTX with those receiving conventional therapy. Methods...... organ manifestations for which either RTX or conventional therapy was initiated were lupus nephritis followed by musculoskeletal and haematological. The reason for treatment was, besides disease control, corticosteroid-sparing for patients treated with conventional therapy. Conclusions: RTX use for SLE...

An Lck-cre transgene accelerates autoantibody production and lupus development in (NZB × NZW)F1 mice

Science.gov (United States)

Nelson, Richard K.; Gould, Karen A.

2015-01-01

Lupus is an autoimmune disease characterized by the development of antinuclear autoantibodies and immune complex-mediated tissue damage. T cells in lupus patients appear to undergo apoptosis at an increased rate, and this enhanced T cell apoptosis has been postulated to contribute to lupus pathogenesis by increasing autoantigen load. However, there is no direct evidence to support this hypothesis. In this study, we show that an Lck-cre transgene, which increases T cell apoptosis as a result of T cell specific expression of cre recombinase, accelerates the development of autoantibodies and nephritis in lupus-prone (NZB×NZW)F1 mice. Although the enhanced T cell apoptosis in Lck-cre transgenic mice resulted in an overall decrease in the relative abundance of splenic CD4+ and CD8+ T cells, the proportion of activated CD4+ T cells was increased and no significant change was observed in the relative abundance of suppressive T cells. We postulate that the Lck-cre transgene promoted lupus by enhancing T cells apoptosis, which, in conjunction with the impaired clearance of apoptotic cells in lupus-prone mice, increased the nuclear antigen load and accelerated the development of anti-nuclear autoantibodies. Furthermore, our results also underscore the importance of including cre-only controls in studies using the cre-lox system. PMID:26385218

El significado de la histerectomía para un grupo de hombres chilenos parejas de histerectomizadas O significado da histerectomia para um grupo de homens chilenos parceiros de histerectomizadas The meaning of hysterectomy for a group of chilean men partners of women who have undergone hysterectomy

Directory of Open Access Journals (Sweden)

Alejandra Araya Gutiérrez

2012-12-01

Full Text Available Se objetivó conocer el significado de la histerectomía para un grupo de hombres chilenos, parejas de mujeres histerectomizadas (HPMH. Estudio cualitativo, con entrevistas en profundidad realizadas a 15 hombres, parejas de mujeres histerectomizadas, entre Mayo y Septiembre del 2010, previa aprobación de dos Comités de Ética. Para el análisis de los datos se utilizó la perspectiva fenomenológica descrita por Giorgi, y se realizó el análisis de contenido según Krippendorff. Los criterios de Creswell fueron utilizados para evaluar la credibilidad del análisis y asegurar la validez descriptiva. Emergieron cinco dimensiones que representan aspectos únicos del significado de la histerectomía para los hombres parejas de mujeres histerectomizadas: síntomas, comentarios, atributos del útero, preocupaciones, y cambios en la sexualidad. Educar los hombres parejas de mujeres histerectomizadas es una acción fundamental para apoyar a las mujeres que serán sometidas a una histerectomía, siendo necesaria su incorporación en el plan de cuidados de ellas.O objetivo deste estudo foi conhecer o significado da histerectomia para um grupo de homens chilenos, parceiros de mulheres histerectomizadas (HPMH. A pesquisa qualitativa foi realizada com entrevistas em profundidade, realizada com um total de quinze homens parceiros de mulheres histerectomizadas, entre maio e setembro de 2010, com aprovação prévia dos Comitês de Ética. Para a análise dos dados foi utilizada a perspectiva fenomenológica descrita por Giorgi e realizada a análise de conteúdo de acordo com Krippendorff. Os critérios de Crestwell foram utilizados para avaliar a credibilidade da análise e garantir a validez descritiva. Surgiram cinco dimensões que representam aspectos únicos do significado da extração do útero para os homens parceiros de mulheres histerectomizadas: sintomas, comentários, atribuições do útero, preocupações e mudanças na sexualidade. Educar os

New study shows normally helpful natural bacteria may also trigger lupus | Center for Cancer Research

Science.gov (United States)

CCR scientists have discovered that a protein produced by bacteria that naturally inhabit our bodies may trigger the autoimmune disease lupus. The results of the study could unveil an entirely new set of drug targets for treating lupus and other autoimmune diseases. Read more…

The SOLA Team: A Star Formation Project To Study the Soul of Lupus with ALMA

Science.gov (United States)

De Gregorio-Monsalvo, Itziar; Saito, M.; Rodon, J.; Takahashi, S.

2017-06-01

The SOLA team is a multi-national and multi-wavelength collaboration composed by scientists with technical expertise in ALMA and in infrared and optical techniques. The aim of the team is to establish a low-mass star formation scenario based on the Lupus molecular clouds. In this talk I will present our unique catalog of pre-stellar and proto-stellar cores toward Lupus molecular clouds, the results on our latest studies in protoplanetary disks, as well as our ALMA Cycle 3 data aiming at testing the formation mechanism of sub-stellar objects in Lupus molecular clouds.

Sunlight Triggers Cutaneous Lupus through a Colony Stimulating Factor-1 (CSF-1) Dependent Mechanism in MRL-Faslpr mice

Science.gov (United States)

Menke, Julia; Hsu, Mei-Yu; Byrne, Katelyn T.; Lucas, Julie A.; Rabacal, Whitney A.; Croker, Byron P.; Zong, Xiao-Hua; Stanley, E. Richard; Kelley, Vicki R.

2008-01-01

Sunlight (UVB) triggers cutaneous (CLE) and systemic lupus through an unknown mechanism. We tested the hypothesis that UVB triggers CLE through a CSF-1-dependent, macrophage (Mø) -mediated mechanism in MRL-Faslpr mice. By constructing mutant MRL-Faslpr strains expressing varying levels of CSF-1 (high, intermediate, none), and use of an ex-vivo gene transfer to deliver CSF-1 intra-dermally, we determined that CSF-1 induces CLE in lupus-susceptible, MRL-Faslpr mice, but not in lupus-resistant, BALB/c mice. Notably, UVB incites an increase in Mø, apoptosis in the skin and CLE in MRL-Faslpr, but not in CSF-1-deficient MRL-Faslpr mice. Furthermore, UVB did not induce CLE in BALB/c mice. Probing further, UVB stimulates CSF-1 expression by keratinocytes leading to recruitment and activation of Mø that, in turn, release mediators, which induce apoptosis in keratinocytes. Thus, sunlight triggers a CSF-1-dependent, Mø-mediated destructive inflammation in the skin leading to CLE in lupus-susceptible MRL-Faslpr, but not lupus-resistant BALB/c mice. Taken together, we envision CSF-1 as the “match” and lupus-susceptibility as the “tinder” leading to CLE. PMID:18981160

Socioeconomic status and organ damage in Mexican systemic lupus erythematosus women.

Science.gov (United States)

Mendoza-Pinto, C; Méndez-Martínez, S; Soto-Santillán, P; Galindo Herrera, J; Pérez-Contreras, I; Macías-Díaz, S; Taboada-Cole, A; García-Carrasco, M

2015-10-01

The objective of this cross-sectional study was to determine relationships between socioeconomic status and organ damage in Mexican systemic lupus erythematosus (SLE) patients. Demographic and clinical variables were assessed. Socioeconomic status was evaluated using the Graffar method and monthly household income. Lupus activity and organ damage were measured using the SLE disease activity scale, validated for the Mexican population (Mex-SLEDAI), and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) scale. The 143 Mexican female SLE patients included (mean age 40.1 ± 8.9 years, mean disease duration 8.9 ± 6.3 years) had a mean monthly household income of $ 407.2 ± 326.5. According to the Graffar index, 18.9%, 52.5%, and 28.7% had high/medium-high, medium, and medium-low/low socioeconomic status, respectively. Organ damage was observed in 61 patients (42.7%). Patients with organ damage had lower monthly household incomes ($241.4 ± 152.4 vs. $354.8 ± 288.3) and were more frequently unemployed (57.3% vs. 35.3%; p = 0.01) than those without. Low monthly income was not associated with lupus activity or self-reported health status. In the adjusted multivariate analysis, low monthly income ( < $300) was associated with organ damage. In conclusion, low income may be associated with organ damage in Mexican SLE patients. © The Author(s) 2015.

Mapping Perceptions of Lupus Medication Decision-Making Facilitators: The Importance of Patient Context.

Science.gov (United States)

Qu, Haiyan; Shewchuk, Richard M; Alarcón, Graciela; Fraenkel, Liana; Leong, Amye; Dall'Era, Maria; Yazdany, Jinoos; Singh, Jasvinder A

2016-12-01

Numerous factors can impede or facilitate patients' medication decision-making and adherence to physicians' recommendations. Little is known about how patients and physicians jointly view issues that affect the decision-making process. Our objective was to derive an empirical framework of patient-identified facilitators to lupus medication decision-making from key stakeholders (including 15 physicians, 5 patients/patient advocates, and 8 medical professionals) using a patient-centered cognitive mapping approach. We used nominal group patient panels to identify facilitators to lupus treatment decision-making. Stakeholders independently sorted the identified facilitators (n = 98) based on their similarities and rated the importance of each facilitator in patient decision-making. Data were analyzed using multidimensional scaling and hierarchical cluster analysis. A cognitive map was derived that represents an empirical framework of facilitators for lupus treatment decisions from multiple stakeholders' perspectives. The facilitator clusters were 1) hope for a normal/healthy life, 2) understand benefits and effectiveness of taking medications, 3) desire to minimize side effects, 4) medication-related data, 5) medication effectiveness for "me," 6) family focus, 7) confidence in physician, 8) medication research, 9) reassurance about medication, and 10) medication economics. Consideration of how different stakeholders perceive the relative importance of lupus medication decision-making clusters is an important step toward improving patient-physician communication and effective shared decision-making. The empirically derived framework of medication decision-making facilitators can be used as a guide to develop a lupus decision aid that focuses on improving physician-patient communication. © 2016, American College of Rheumatology.

What Social Workers in Health Care Should Know about Lupus: A Structural Equation Model

Science.gov (United States)

Auerbach, Charles; Beckerman, Nancy L.

2011-01-01

This article reports on findings from a cross-sectional study (N = 378) of patients living with systemic lupus erythematosus (SLE). The purpose of this study was to identify and clarify the unique psychosocial challenges for those living with lupus. The specific analysis will help to develop a model to determine how different factors influence SLE…

Clinical correlates and outcomes in a group of Puerto Ricans with systemic lupus erythematosus hospitalized due to severe infections

Science.gov (United States)

Jordán-González, Patricia; Shum, Lee Ming; González-Sepúlveda, Lorena

2018-01-01

Objective: Infections are a major cause of morbidity and mortality in systemic lupus erythematosus. Clinical outcomes of systemic lupus erythematosus patients hospitalized due to infections vary among different ethnic populations. Thus, we determined the outcomes and associated factors in a group of Hispanics from Puerto Rico with systemic lupus erythematosus admitted due to severe infections. Methods: Records of systemic lupus erythematosus patients admitted to the Adult University Hospital, San Juan, Puerto Rico, from January 2006 to December 2014 were examined. Demographic parameters, lupus manifestations, comorbidities, pharmacologic treatments, inpatient complications, length of stay, readmissions, and mortality were determined. Patients with and without infections were compared using bivariate and multivariate analyses. Results: A total of 204 admissions corresponding to 129 systemic lupus erythematosus patients were studied. The mean (standard deviation) age was 34.7 (11.6) years; 90% were women. The main causes for admission were lupus flare (45.1%), infection (44.0%), and initial presentation of systemic lupus erythematosus (6.4%). The most common infections were complicated urinary tract infections (47.0%) and soft tissue infections (42.0%). In the multivariate analysis, patients admitted with infections were more likely to have diabetes mellitus (odds ratio: 4.20, 95% confidence interval: 1.23–14.41), exposure to aspirin prior to hospitalization (odds ratio: 4.04, 95% confidence interval: 1.03–15.80), and higher mortality (odds ratio: 6.00, 95% confidence interval: 1.01–35.68) than those without infection. Conclusion: In this population of systemic lupus erythematosus patients, 44% of hospitalizations were due to severe infections. Patients with infections were more likely to have diabetes mellitus and higher mortality. Preventive and control measures of infection could be crucial to improve survival in these patients.

Treating lupus in the kidney: where are we now, and where are we going?

Science.gov (United States)

Canetta, Pietro A A; Bomback, Andrew S; Radhakrishnan, Jai

2011-10-01

Kidney involvement is a frequent and dreaded consequence of systemic lupus erythematosus. While historically this condition was devastatingly morbid, over the past thirty years an improved understanding of the disease's pathobiology has accompanied increasingly effective treatment regimens that have dramatically improved the prognosis for affected patients. Induction and maintenance of remission can now be obtained in the majority of patients, although at least 20-30% may be refractory to treatment. What's more, the standard drugs in use for lupus nephritis remain fairly broad immunosuppressants, and carry notable risks and side effects. Recent years have witnessed an explosion in the number of novel immunomodulatory drugs being developed, with increasingly specific targets of action in the immune system. These molecules hold promise for a range of autoimmune disorders, including lupus nephritis, and several are already being actively investigated for that purpose. Here we review the current state of the art in the treatment of lupus nephritis, highlight the limits of standard treatments, and discuss the most promising of the novel therapies coming down the pipeline.

Systemic lupus erythematosus serositis

Energy Technology Data Exchange (ETDEWEB)

Low, V.H.S.; Robins, P.D.; Sweeney, D.J. [Sir Charles Gairdner Hospital, Perth, WA (Australia). Dept. of Diagnostic Radiology

1995-08-01

The imaging appearances of a case of systemic lupus erythematosus, which manifested initially as a serositis, is described. Barium small bowel study showed segments of spiculation with tethering, angulation, and obstruction. Computed tomography scan of the abdomen confirmed ascites. It was also useful in demonstrating free fluid, bowel wall oedema, and serosal thickening . Follow up scanning to demonstrate resolution of changes may also be of value. The definitive diagnosis was made on the basis of marked elevation of antinuclear and anti-double stranded DNA antibodies. 10 refs., 2 figs.

CanisOme--The protein signatures of Canis lupus familiaris diseases.

Science.gov (United States)

Fernandes, Mónica; Rosa, Nuno; Esteves, Eduardo; Correia, Maria José; Arrais, Joel; Ribeiro, Paulo; Vala, Helena; Barros, Marlene

2016-03-16

Although the applications of Proteomics in Human Biomedicine have been explored for some time now, in animal and veterinary research, the potential of this resource has just started to be explored, especially when companion animal health is considered. In the last years, knowledge on the Canis lupus familiaris proteome has been accumulating in the literature and a resource compiling all this information and critically reviewing it was lacking. This article presents such a resource for the first time. CanisOme is a database of all proteins identified in Canis lupus familiaris tissues, either in health or in disease, annotated with information on the proteins present on the sample and on the donors. This database reunites information on 549 proteins, associated with 63 dog diseases and 33 dog breeds. Examples of how this information may be used to produce new hypothesis on disease mechanisms is presented both through the functional analysis of the proteins quantified in canine cutaneous mast cell tumors and through the study of the interactome of C. lupus familiaris and Leishmania infantum. Therefore, the usefulness of CanisOme for researchers looking for protein biomarkers in dogs and interested in a comprehensive analysis of disease mechanisms is demonstrated. This paper presents CanisOme, a database of proteomic studies with relevant protein annotation, allowing the enlightenment of disease mechanisms and the discovery of novel disease biomarkers for C. lupus familiaris. This knowledge is important not only for the improvement of animal health but also for the use of dogs as models for human health studies. Copyright © 2016 Elsevier B.V. All rights reserved.

Reforma tributaria de 2014 y efecto en el mercado bursátil chileno

Directory of Open Access Journals (Sweden)

Edinson Cornejo Saavedra

2016-12-01

Full Text Available Este estudio midió el efecto de la Reforma Tributaria de 2014 en el mercado bursátil chileno, entre el período de anuncio y de aprobación en el Congreso. Se analizaron los retornos anormales de las 40 empresas del IPSA agrupadas por industria, utilizando la metodología de estudio de eventos. Se analizaron cuatro eventos: el envío del Proyecto de Ley de Reforma Tributaria al Congreso; la aprobación en general del Proyecto de Reforma por la Cámara de Diputados; la celebración de un acuerdo por la Reforma Tributaria entre el Gobierno y la Alianza; y la aprobación de la Reforma por el Congreso. Se concluyó que el primer evento habría generado retornos anormales promedio negativos y significativos sólo en la industria de manufactura; que el segundo evento habría originado retornos anormales promedio negativos no significativos un día después en las industrias de manufactura, bancaria y financiera, inmobiliaria y de transporte; que el tercer evento generó retornos anormales positivos y significativos en las industrias inmobiliaria y de retail; y que el último tuvo efectos mixtos y no concluyentes.

[Dyslipidaemia and atherogenic risk in patients with systemic lupus erythematosus].

Science.gov (United States)

Batún Garrido, José Antonio de Jesús; Radillo Alba, Hugo Alberto; Hernández Núñez, Éufrates; Olán, Francisco

2016-07-15

Dyslipidaemia is a common comorbidity in patients with systemic lupus erythematosus. Fifty-one patients were included. Variables associated with the disease and the drugs used were recorded. Atherogenic risk was calculated. Chi square was used for categorical variables. ANOVA was performed and a logistic regression model to determine the association of the variables with the presence of dyslipidaemia. A percentage of 68.6 had dyslipidaemia. A significant difference between the presence of dyslipidaemia and activity index measured by SLEDAI was found, the presence of lupus nephritis, use of prednisone≥20mg/day, evolution of the disease<3 years. Significance between the absence of dyslipidaemia and use of hydroxychloroquine was found. SLEDAI≥4 and the use of prednisone≥20mg/day were independently associated with the presence of dyslipidaemia. The average of Castelli rate was 5.02, the Kannel index was 2.97 and triglyceride/HDL-C ratio was 5.24. Patients with systemic lupus erythematosus have a high prevalence of dyslipidaemia and a high atherogenic rate, which increases cardiovascular risk significantly. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

HERBIG-HARO OBJECTS IN THE LUPUS I AND III MOLECULAR CLOUDS

International Nuclear Information System (INIS)

Wang Hongchi; Henning, Thomas

2009-01-01

We performed a deep search for Herbig-Haro (HH) objects toward the Lupus I and III clouds, covering a sky area of ∼ 1 and ∼ 0.5 deg 2 , respectively. In total, 11 new HH objects, HH 981--991, are discovered. The HH objects both in Lupus I and in Lupus III tend to be concentrated in small areas. The HH objects detected in Lupus I are located in a region of radius 0.26 pc near the young star Sz 68. The abundance of HH objects shows that this region of the cloud is active in on-going star formation. HH objects in the Lup III cloud are concentrated in the central part of the cloud around the Herbig Ae/Be stars HR 5999 and 6000. HH 981 and 982 in Lupus I are probably driven by the young brown dwarf SSTc2d J154457.9-342340 which has a mass of 50 M J . HH 990 and 991 in Lup III align well with the HH 600 jet emanating from the low-mass star Par-Lup3-4, and are probably excited by this low-mass star of spectral type M5. High proper motions for HH 228 W, E, and E2 are measured, which confirms that they are excited by the young star Th 28. In contrast, HH 78 exhibits no measurable proper motion in the time span of 18 years, indicating that HH 78 is unlikely part of the HH 228 flow. The HH objects in Lup I and III are generally weak in terms of brightness and dimension in comparison to HH objects we detected with the same technique in the R CrA and Cha I clouds. Through a comparison with the survey results from the Spitzer c2d program, we find that our optical survey is more sensitive, in terms of detection rate, than the Spitzer IRAC survey to high-velocity outflows in the Lup I and III clouds.

A Case of Systemic Lupus Erythematosus developing Two years after Remission of Thrombotic Thrombocytopenic Purpura

Science.gov (United States)

Myung, Seung-Jae; Yoo, Bin; Lee, Kyoo-Hyung; Yoo, Mi-Ran; Choi, Seung-Won; Yoo, Eun-Sil; Chi, Hyun-Sook; Moon, Hee-Bom

1996-01-01

We describe a 17-year-old male who presented with thrombotic thrombocytopenic purpura (TTP) and 2 years thereafter developed central nervous system lupus and nephritis. The association of TTP and systemic lupus erythematosus has been described, but the unusual sequence and chronological separation is very rare. PMID:8854658

Mitral Valve Surgery in Patients with Systemic Lupus Erythematosus

Science.gov (United States)

Hekmat, Manouchehr; Ghorbani, Mohsen; Ghaderi, Hamid; Majidi, Masoud; Beheshti, Mahmood

2014-01-01

Valvular heart disease is the common cardiac manifestation of systemic lupus erythematosus (SLE) with a tendency for mitral valve regurgitation. In this study we report a case of mitral valve replacement for mitral stenosis caused by Libman-Sacks endocarditis in the setting of SLE. In addition, we provide a systematic review of the literature on mitral valve surgery in the presence of Libman-Sacks endocarditis because its challenge on surgical options continues. Surgical decision depends on structural involvement of mitral valve and presence of active lupus nephritis and antiphospholipid antibody syndrome. Review of the literature has also shown that outcome is good in most SLE patients who have undergone valvular surgery, but association of antiphospholipid antibody syndrome with SLE has negative impact on the outcome. PMID:25401131

MASTICATORY MUSCLE MYOSITIS IN A GRAY WOLF (CANIS LUPUS).

Science.gov (United States)

Kent, Marc; Glass, Eric N; Castro, Fernando A; Miller, Andrew D; de Lahunta, Alexander

2017-03-01

A 10-yr-old male, neutered gray wolf ( Canis lupus ) was presented for atrophy of the temporalis and masseter muscles. Clinical signs and magnetic resonance imaging were consistent with a myopathy. Positive serology for antibody titers directed against Type 2M myofibers, and the observation of a mixed mononuclear inflammatory cell infiltrate along with eosinophils and neutrophils within the temporalis muscle, were diagnostic for masticatory muscle myositis. Importantly, protozoal myositis was excluded based on other clinicopathologic data. The case highlights the potential for immune-mediated polymyositis in canids other than the domesticated dog ( Canis lupus familaris). Additionally, awareness of a diet in which raw meat is used should prompt a thorough investigation for an underlying infectious myositis in the gray wolf.

Isolated HBsAg positivity in a Mexican patient with newly diagnosed lupus nephritis

Directory of Open Access Journals (Sweden)

Guillermo Delgado-García

2017-01-01

Conclusions: Isolated HBsAg positivity may result from multiple causes, one of which is cross-reactivity. To the best of our knowledge, this is the first report of a false-positive reading using CMIA technique in an active lupus patient. It is reasonable to stress that lupus patients with a positive screening for HBV should undergo a confirmatory assay (such as genomic detection, since this diagnosis may have important therapeutic implications.

Patologías dentales en incisivos, caninos y primer premolar en caballos chilenos adultos Dental pathologies in incisors, canines and first premolar in adult Chilean horses

OpenAIRE

L Muñoz; F Vidal; O Sepúlveda; O Ortiz; C Rehhof

2010-01-01

Las patologías dentales han ido tomando mayor relevancia clínico veterinaria, aumentando el número de consultas, tratamientos y procedimientos preventivos. En caballos chilenos, la información existente de patologías dentales es nula, por lo que se hace primordial la investigación y recolección de datos en esta raza. Se analizaron 100 caballos pertenecientes a la Asociación de Rodeo Concepción, entre los meses de junio y septiembre del año 2007. Los materiales que se utilizaron fueron puro, l...

FK506: therapeutic effects on lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr mice.

Science.gov (United States)

Furukawa, F; Imamura, S; Takigawa, M

1995-01-01

The effects of FK506, a new immunosuppressive agent, on the development of lupus dermatoses were investigated in the autoimmune-prone MRL/Mp-lpr/lpr (MRL/lpr) mouse, which is an animal model for the spontaneous development of skin lesions similar to those of human lupus erythematosus (LE). FK506 reduced the incidence of skin lesions, lupus nephritis, the titre of serum anti-double-stranded DNA antibodies and the massive T cell proliferation. The incidence and magnitude of IgG deposition at the dermoepidermal junction were not changed. These results suggest that FK506 is a promising immunosuppressive agent for the control of autoimmune skin diseases.

Problemas éticos y consecuencias reconocidas por psicólogos nóveles en reclutamiento y selección de personal

OpenAIRE

Rodríguez Araneda, María José; Navarrete Moraga, Robinson; Bargsted Aravena, Mariana

2017-01-01

Resumen: Con base en la ética profesional en el ejercicio de la psicología del trabajo y las organizaciones, se realizó una investigación cualitativa desde el enfoque de la teoría fundamentada constructivista con el objetivo de describir problemas éticos reconocidos en procesos de reclutamiento y selección de personal, así como sus consecuencias, con la participación de 40 psicólogos nóveles chilenos. Los problemas reconocidos fueron discriminación, en especial de género, favorecer candidatos...

[Systemic lupus erythematodes].

Science.gov (United States)

Lukác, J; Rovenský, J; Lukácová, O; Kozáková, D

2006-01-01

Systemic lupus erythematodes (SLE) is chronic autoimmune disease, characteristic by production of autoantibodies against different autoantigens. Etiopathogenesis in not precise determinated, but genetic, immunologic, hormonal factors or influence of environment are assumed. It manifests by various symptoms and it can affect whichever organ or system in the body. Clinical manifestation are due chronic inflammation in the tissues, which is caused first of all by deposit of immunocomplex and by cytotoxic damage. At the last decades the mortality of patients with SLE is markly lower and their live is prolong. In spite of this diagnostic, to follow up and therapy of this disease is complicated and it requires the colaboration of more branches of medicine.

Systemic lupus erythematosus and renal tubular acidosis associated with hyperthyroidism. Case Report.

Science.gov (United States)

Deng, Datong; Sun, Li; Xia, Tongjia; Xu, Min; Wang, Youmin; Zhang, Qiu

2016-07-01

A case of a 42-year-old female with hyperthyroidism was subsequently diagnosed to have systemic lupus erythematosus with distal RTA. The clinical examination on admission showed swelling of the knee joints and the urinalysis showed pH 6.5, pro 3+. Her blood routine results were as follows: white blood cells 1.85×109/L, platelets 100×109/L, erythrocyte 3.06×1012/L. The serum potassium was 3.11 mmol/L, 24 hour urinary electrolyte: K 68.87 mmol/24 H, antinuclear antibodies (ANA) 1:1 000, speckled pattern. The anti-double stranded DNA antibody (anti-dsDNA), anti SS-A(52) antibody and anti SS-A(60) antibody were positive. The light microscopy and immunofluorescence showed diffuse proliferative lupus nephritis. These data were compatible with the diagnosis of systemic lupus erythematosus. The diagnosis of hyperthyroidism and distal RTA is clear. This report showed that other autoimmune disease in the diagnosis of hyperthyroidism should not be ignored.

Teoría del Cambio Subjetivo: Aportes desde un Estudio Cualitativo con Profesores / The Theory of Subjective Change: Contributions from a Qualitative Study with Teachers / Teoria da Mudança Subjetiva: Contribuições de um Estudo Qualitativo com Professores

Directory of Open Access Journals (Sweden)

PABLO J. CASTRO

2015-10-01

Full Text Available Se reportan los hallazgos de una investigación que reconstruye la teoría subjetiva de un grupo de docentes participantes de un diplomado de educación en valores acerca de su propio proceso de cambio. A una muestra de 12 profesores chilenos se le realizaron 35 entrevistas y se analizaron algunos documentos personales. La información se procesó mediante análisis cualitativo descriptivo y relacional, y fue codificada utilizando el programa ATLAS.ti. Los resultados indicaron que los participantes distinguen factores externos y propios como causas de sus cambios, diferencian entre vida personal y trabajo con incipientes explicaciones al integrar ambas dimensiones, y reconocen la importancia del cambio personal en el cambio profesional.

Treat-to-target in systemic lupus erythematosus

DEFF Research Database (Denmark)

Mosca, Marta; Boumpas, Dimitrios T; Bruce, Ian N

2013-01-01

on May 8, 2012 to discuss whether a treat-to-target approach could be applied in the treatment of systemic lupus erythematosus (SLE) (T2T/SLE), define a research agenda, and establish a plan for moving forward. In the present paper, observations raised at the meeting and literature data on potential...

Perihepatitis associated with systemic lupus erythematosus: computed tomography findings

International Nuclear Information System (INIS)

Schoenwaelder, M.; Stuckey, S.L.

2005-01-01

The imaging findings of a 29-year-old woman with known systemic lupus erythematosus, and a clinical presentation and CT appearances consistent with perihepatitis are presented Copyright (2005) Blackwell Publishing Asia Pty Ltd

Skin lesion resembling malignant atrophic papulosis in lupus erythematosus.

Science.gov (United States)

Doutre, M S; Beylot, C; Bioulac, P; Busquet, M; Conte, M

1987-01-01

This case demonstrates, as do the 3 others reported in literature, that a diagnosis of malignant atrophic papulosis can only be made once the possibility of a lupus erythematosus has been totally excluded.

Paraoxonase 1 activity and genotyping in systemic lupus ...

African Journals Online (AJOL)

Introduction: Systemic lupus erythematosus (SLE) is characterized by an enhanced risk of atherosclerosis and cardiovascular diseases (CVD). Human serum paraoxonase 1 (PON1), an antioxidant enzyme closely associated with high density lipoprotein (HDL), has been implicated in the prevention of low density ...

Ocular findings in systemic lupus erythemato

Directory of Open Access Journals (Sweden)

Samir S. Shoughy

2016-04-01

Full Text Available Systemic lupus erythematosus (SLE is a chronic multisystem autoimmune disease. Ocular complications occur in up to one-third of patients with SLE. The ocular findings may represent the initial manifestation of the disease and may lead to severe ocular morbidity and loss of vision. Early diagnosis and prompt management of patients with SLE are mandatory and require collaboration between the ophthalmologist and the rheumatologist.

Ocular findings in systemic lupus erythematosus.

Science.gov (United States)

Shoughy, Samir S; Tabbara, Khalid F

2016-01-01

Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease. Ocular complications occur in up to one-third of patients with SLE. The ocular findings may represent the initial manifestation of the disease and may lead to severe ocular morbidity and loss of vision. Early diagnosis and prompt management of patients with SLE are mandatory and require collaboration between the ophthalmologist and the rheumatologist.

Sweet syndrome revealing systemic lupus erythematosus.

LENUS (Irish Health Repository)

Quinn, N

2015-02-01

Sweet Syndrome is an acute inflammatory skin eruption which is rare in children. We report a case of childhood Systemic Lupus Erythematosus (SLE) that presented with Sweet syndrome. This case is a unique presentation of a common disorder which provides a new facet for the differential diagnosis of SLE in children. It is also the first paediatric case to be reported in a Caucasian child.

Lupus nephritis in Lebanon.

Science.gov (United States)

Uthman, I W; Muffarij, A A; Mudawar, W A; Nasr, F W; Masri, A F

2001-01-01

This is a retrospective study of the clinicopathological characteristics of 50 systemic lupus erythematosus patients with nephritis who underwent a kidney biopsy and were admitted to the American University of Beirut Medical Center, in Lebanon, between 1979 and 1999. There were 43 females and seven males, with a median age of 24 y. Renal histology slides from these patients were assessed according to the World Health Organization classification, and were distributed as follows: class I (n = 3, 6%); class II (n = 14, 28%); class III (n = 11, 22%); class IV (n = 19, 38%); class V (n = 1, 2%); class VI (n = 2, 4%). All the patients received oral prednisone, in addition the following treatments were used: pulse intravenous (i.v.) cyclophosphamide (n = 23, 46%); azathioprine (n = 22, 44%); pulse i.v. steroids (n = 19, 38%); chloroquine sulfate (n = 17, 34%); methotrexate (n = 5, 10%); and plasmapheresis (n = 2, 4%). The median duration of follow-up was 5 y (range 1-33 y). On their last evaluation, out of 37 patients who were followed, 20 patients (54%) had controlled disease, eight patients (22%) were still on active medical treatment, four patients (11%) were on chronic hemodialysis, and five patients (13%) had died. Unlike three other Arab populations studies from Kuwait, United Arab Emirates and Saudi Arabia, where the most frequent histopathologic abnormality was class III, diffuse proliferative LN (class IV) was the most common type of lupus nephritis in Lebanon, similarly to reports from USA, France, Netherlands, South Africa, Thailand and Taiwan.

Semi-quantitative evaluation of gallium-67 scintigraphy in lupus nephritis

International Nuclear Information System (INIS)

Lin Wanyu; Hsieh Jihfang; Tsai Shihchuan; Lan Joungliang; Cheng Kaiyuan; Wang Shyhjen

2000-01-01

Within nuclear medicine there is a trend towards quantitative analysis. Gallium renal scan has been reported to be useful in monitoring the disease activity of lupus nephritis. However, only visual interpretation using a four-grade scale has been performed in previous studies, and this method is not sensitive enough for follow-up. In this study, we developed a semi-quantitative method for gallium renal scintigraphy to find a potential parameter for the evaluation of lupus nephritis. Forty-eight patients with lupus nephritis underwent renal biopsy to determine World Health Organization classification, activity index (AI) and chronicity index (CI). A delayed 48-h gallium scan was also performed and interpreted by visual and semi-quantitative methods. For semi-quantitative analysis of the gallium uptake in both kidneys, regions of interest (ROIs) were drawn over both kidneys, the right forearm and the adjacent spine. The uptake ratios between these ROIs were calculated and expressed as the ''kidney/spine ratio (K/S ratio)'' or the ''kidney/arm ratio (K/A ratio)''. Spearman's rank correlation test and Mann-Whitney U test were used for statistical analysis. Our data showed a good correlation between the semi-quantitative gallium scan and the results of visual interpretation. K/S ratios showed a better correlation with AI than did K/A ratios. Furthermore, the left K/S ratio displayed a better correlation with AI than did the right K/S ratio. In contrast, CI did not correlate well with the results of semi-quantitative gallium scan. In conclusion, semi-quantitative gallium renal scan is easy to perform and shows a good correlation with the results of visual interpretation and renal biopsy. The left K/S ratio from semi-quantitative renal gallium scintigraphy displays the best correlation with AI and is a useful parameter in evaluating the disease activity in lupus nephritis. (orig.)

ALMA Survey of Lupus Protoplanetary Disks. II. Gas Disk Radii

Science.gov (United States)

Ansdell, M.; Williams, J. P.; Trapman, L.; van Terwisga, S. E.; Facchini, S.; Manara, C. F.; van der Marel, N.; Miotello, A.; Tazzari, M.; Hogerheijde, M.; Guidi, G.; Testi, L.; van Dishoeck, E. F.

2018-05-01

We present Atacama Large Millimeter/Sub-Millimeter Array (ALMA) Band 6 observations of a complete sample of protoplanetary disks in the young (∼1–3 Myr) Lupus star-forming region, covering the 1.33 mm continuum and the 12CO, 13CO, and C18O J = 2–1 lines. The spatial resolution is ∼0.″25 with a medium 3σ continuum sensitivity of 0.30 mJy, corresponding to M dust ∼ 0.2 M ⊕. We apply Keplerian masking to enhance the signal-to-noise ratios of our 12CO zero-moment maps, enabling measurements of gas disk radii for 22 Lupus disks; we find that gas disks are universally larger than millimeter dust disks by a factor of two on average, likely due to a combination of the optically thick gas emission and the growth and inward drift of the dust. Using the gas disk radii, we calculate the dimensionless viscosity parameter, α visc, finding a broad distribution and no correlations with other disk or stellar parameters, suggesting that viscous processes have not yet established quasi-steady states in Lupus disks. By combining our 1.33 mm continuum fluxes with our previous 890 μm continuum observations, we also calculate the millimeter spectral index, α mm, for 70 Lupus disks; we find an anticorrelation between α mm and millimeter flux for low-mass disks (M dust ≲ 5), followed by a flattening as disks approach α mm ≈ 2, which could indicate faster grain growth in higher-mass disks, but may also reflect their larger optically thick components. In sum, this work demonstrates the continuous stream of new insights into disk evolution and planet formation that can be gleaned from unbiased ALMA disk surveys.

Filaments in Lupus I

Science.gov (United States)

Takahashi, Satoko; Rodon, J.; De Gregorio-Monsalvo, I.; Plunkett, A.

2017-06-01

The mechanisms behind the formation of sub-stellar mass sources are key to determine the populations at the low-mass end of the stellar distribution. Here, we present mapping observations toward the Lupus I cloud in C18O(2-1) and 13CO(2-1) obtained with APEX. We have identified a few velocity-coherent filaments. Each contains several substellar mass sources that are also identified in the 1.1mm continuum data (see also SOLA catalogue presentation). We will discuss the velocity structure, fragmentation properties of the identified filaments, and the nature of the detected sources.

Circulating TFH subset distribution is strongly affected in lupus patients with an active disease.

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Carole Le Coz

Full Text Available Follicular helper T cells (TFH represent a distinct subset of CD4(+ T cells specialized in providing help to B lymphocytes, which may play a central role in autoimmune diseases having a major B cell component such as systemic lupus erythematosus. Recently, TFH subsets that share common phenotypic and functional characteristics with TFH cells from germinal centers, have been described in the peripheral blood from healthy individuals. The aim of this study was to analyze the distribution of such populations in lupus patients. Circulating TFH cell subsets were defined by multicolor flow cytometry as TFH17 (CXCR3(-CCR6(+, TFH1 (CXCR3 (+ CCR6(- or TFH2 (CXCR3(-CCR6(- cells among CXCR5 (+ CD45RA(-CD4(+ T cells in the peripheral blood of 23 SLE patients and 23 sex and age-matched healthy controls. IL-21 receptor expression by B cells was analyzed by flow cytometry and the serum levels of IL-21 and Igs were determined by ELISA tests. We found that the TFH2 cell subset frequency is strongly and significantly increased in lupus patients with an active disease (SLEDAI score>8, while the TFH1 cell subset percentage is greatly decreased. The TFH2 and TFH1 cell subset frequency alteration is associated with the presence of high Ig levels and autoantibodies in patient's sera. Moreover, the TFH2 cell subset enhancement correlates with an increased frequency of double negative memory B cells (CD27(-IgD(-CD19(+ cells expressing the IL-21R. Finally, we found that IgE levels in lupus patients' sera correlate with disease activity and seem to be associated with high TFH2 cell subset frequency. In conclusion, our study describes for the first time the distribution of circulating TFH cell subsets in lupus patients. Interestingly, we found an increased frequency of TFH2 cells, which correlates with disease activity. Our results suggest that this subset might play a key role in lupus pathogenesis.

The effect of inversion at 8p23 on BLK association with lupus in Caucasian population.

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Bahram Namjou

Full Text Available To explore the potential influence of the polymorphic 8p23.1 inversion on known autoimmune susceptibility risk at or near BLK locus, we validated a new bioinformatics method that utilizes SNP data to enable accurate, high-throughput genotyping of the 8p23.1 inversion in a Caucasian population.Principal components analysis (PCA was performed using markers inside the inversion territory followed by k-means cluster analyses on 7416 European derived and 267 HapMaP CEU and TSI samples. A logistic regression conditional analysis was performed.Three subgroups have been identified; inversion homozygous, heterozygous and non-inversion homozygous. The status of inversion was further validated using HapMap samples that had previously undergone Fluorescence in situ hybridization (FISH assays with a concordance rate of above 98%. Conditional analyses based on the status of inversion were performed. We found that overall association signals in the BLK region remain significant after controlling for inversion status. The proportion of lupus cases and controls (cases/controls in each subgroup was determined to be 0.97 for the inverted homozygous group (1067 cases and 1095 controls, 1.12 for the inverted heterozygous group (1935 cases 1717 controls and 1.36 for non-inverted subgroups (924 cases and 678 controls. After calculating the linkage disequilibrium between inversion status and lupus risk haplotype we found that the lupus risk haplotype tends to reside on non-inversion background. As a result, a new association effect between non-inversion status and lupus phenotype has been identified ((p = 8.18×10(-7, OR = 1.18, 95%CI = 1.10-1.26.Our results demonstrate that both known lupus risk haplotype and inversion status act additively in the pathogenesis of lupus. Since inversion regulates expression of many genes in its territory, altered expression of other genes might also be involved in the development of lupus.

Adalimumab (TNFα Inhibitor Therapy Exacerbates IgA Glomerulonephritis Acute Renal Injury and Induces Lupus Autoantibodies in a Psoriasis Patient

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S. S. Wei

2013-01-01

Full Text Available Adalimumab (Humira is a tumour necrosis factor α (TNFα inhibitor that is approved for the treatment of rheumatoid arthritis, psoriasis, psoriatic arthritis, Crohn's disease, ankylosing spondylitis, and juvenile idiopathic arthritis (Sullivan and Preda (2009, Klinkhoff (2004, and Medicare Australia. Use of TNFα inhibitors is associated with the induction of autoimmunity (systemic lupus erythematosus, vasculitis, and sarcoidosis or sarcoid-like granulomas (Ramos-Casals et al. (2010. We report a patient with extensive psoriasis presenting with renal failure and seropositive lupus markers without classical lupus nephritis after 18 months treatment with adalimumab. He has renal biopsy proven IgA nephritis instead. Renal biopsy is the key diagnostic tool in patients presenting with adalimumab induced nephritis and renal failure. He made a remarkable recovery after adalimumab cessation and steroid treatment. To our knowledge, this is a unique case of a psoriasis patient presenting with seropositive lupus markers without classical lupus nephritis renal failure and had renal biopsy proven IgA glomerulonephritis after receiving adalimumab.

La cultura política del ciudadano y la comunicación política en TV en la transición política del plebiscito chileno (octubre 1988. I. Metodología. II. Conclusiones

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JOSÉ LUIS PIÑUEL RAIGADA

1990-01-01

Full Text Available Exposición de la acotación material y formal del objeto al que se destina la investigación realizada, y cuyo campo de observación es la situación histórica brindada con la campaña política del plebiscito chileno del 5 de octubre de 1988. La prefiguración teórica de este objeto es la responsable de la selección y consistencia de los datos que se han recolectado y procesado, y la que ha motivado a escoger como campo de observación la COMUNICACIÓN POLÍTICA televisiva y la CULTURA POLÍTICA del ciudadano en el Chile Plebiscitario. De la investigación se concluye que la Mediación comunicativa del Plebiscito ha implantado en la Transición chilena un proceso de resignificación cuyo sentido radica más en la "afirmación del cambio" que en la "afirmación de opciones contra", curiosamente ligadas estas últimas, por la vía de la comunicación, a la opción política cuya práctica no era de cambio, sino de continuidad.

Recent insights into the genetic basis of systemic lupus erythematosus.

Science.gov (United States)

Moser, K L; Kelly, J A; Lessard, C J; Harley, J B

2009-07-01

Genetic variation was first shown to be important in systemic lupus erythematosus (SLE or lupus) in the 1970s with associations in the human leukocyte antigen region. Almost four decades later, and with the help of increasingly powerful genetic approaches, more than 25 genes are now known to contribute to the mechanisms that predispose individuals to lupus. Over half of these loci have been discovered in the past 2 years, underscoring the extraordinary success of genome-wide association approaches in SLE. Well-established risk factors include alleles in the major histocompatibility complex region (multiple genes), IRF5, ITGAM, STAT4, BLK, BANK1, PDCD1, PTPN22, TNFSF4, TNFAIP3, SPP1, some of the Fcgamma receptors, and deficiencies in several complement components, including C1q, C4 and C2. As reviewed here, many susceptibility genes fall into key pathways that are consistent with previous studies implicating immune complexes, host immune signal transduction and interferon pathways in the pathogenesis of SLE. Other loci have no known function or apparent immunological role and have the potential to reveal novel disease mechanisms. Certainly, as our understanding of the genetic etiology of SLE continues to mature, important new opportunities will emerge for developing more effective diagnostic and clinical management tools for this complex autoimmune disease.

Retracted Association of STAT4 gene polymorphism with systemic lupus erythematosus / lupus nephritis risk.

Science.gov (United States)

Zhou, Tian-Biao; Jiang, Zong-Pei; Qin, Yuan-Han; Zhou, Jia-Fan

2014-04-16

The association of STAT4 gene polymorphism with systemic lupus erythematosus (SLE) / lupus nephritis (LN) results from the published studies is still conflicting. This meta-analysis was performed to evaluate the relationship between STAT4 rs7574865, rs16833431, rs11889341, rs8179673, rs10168266, rs7582694, rs3821236, rs7601754 gene polymorphism and SLE / LN, and to explore whether STAT4 gene polymorphism could become a predictive marker for SLE / LN risk. Association studies were identified from the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) as of September 1, 2013, and eligible investigations were synthesized using meta-analysis method. 24 investigations were identified for the analysis of association between STAT4 gene polymorphism and SLE, consisting of 31190 patients with SLE and 43940 controls. In STAT4 rs7574865, there was a marked association between T allele or TT genotype and SLE susceptibility (T: OR=1.53, 95% CI: 1.30-1.79, Prs7574865 gene polymorphism was not associated with the LN risk. Our results indicate that T allele or TT homozygous is a significant risk genetic molecular marker to predict the SLE susceptibility and GG genotype is a valuable marker to against the SLE risk, but the association was not found for LN. However, more investigations are required to further clarify the association of the T allele or TT homozygous with SLE / LN susceptibility. This article is protected by copyright. All rights reserved.

Experience of long-term belimumab use in patients with systemic lupus erythematosus (a case report

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Natalia Gennadyevna Klyukvina

2013-01-01

Full Text Available In the past years considerable progress has been made in the treatment of systemic lupus erythe-matosus; however, not all questions have been answered. The range of medications has substan-tially increased. The paper describes a case of the long-term use of the new genetically engineered agent belimumab in a patient with systemic lupus erythematosus.

An Lck-cre transgene accelerates autoantibody production and lupus development in (NZB × NZW)F1 mice.

Science.gov (United States)

Nelson, R K; Gould, K A

2016-02-01

Lupus is an autoimmune disease characterized by the development of antinuclear autoantibodies and immune complex-mediated tissue damage. T cells in lupus patients appear to undergo apoptosis at an increased rate, and this enhanced T cell apoptosis has been postulated to contribute to lupus pathogenesis by increasing autoantigen load. However, there is no direct evidence to support this hypothesis. In this study, we show that an Lck-cre transgene, which increases T cell apoptosis as a result of T cell-specific expression of cre recombinase, accelerates the development of autoantibodies and nephritis in lupus-prone (NZB × NZW)F1 mice. Although the enhanced T cell apoptosis in Lck-cre transgenic mice resulted in an overall decrease in the relative abundance of splenic CD4(+) and CD8(+) T cells, the proportion of activated CD4(+) T cells was increased and no significant change was observed in the relative abundance of suppressive T cells. We postulate that the Lck-cre transgene promoted lupus by enhancing T cell apoptosis, which, in conjunction with the impaired clearance of apoptotic cells in lupus-prone mice, increased the nuclear antigen load and accelerated the development of anti-nuclear autoantibodies. Furthermore, our results also underscore the importance of including cre-only controls in studies using the cre-lox system. © The Author(s) 2015.

Toxic Epidermal Necrolysis-Like Lesions and Systemic Lupus Erythematosus Possibly Triggered by Sulfasalazine

DEFF Research Database (Denmark)

Krabbe, Simon; Gül, Cigdem; Andersen, Bjarne

2016-01-01

elevated ferritin, and muscle wasting. A diagnosis of systemic lupus erythematosus was made, and mycophenolate mofetil and systemic glucocorticoids brought this severe disease under control. Toxic epidermal necrolysis-like lesions and hemophagocytic syndrome have been reported as manifestations of systemic...... lupus erythematosus. This patient possibly had spondyloarthritis or an undifferentiated connective tissue disease at presentation, and we suggest, based on the timing of events, that sulfasalazine may have acted as a trigger of the severe disease manifestations....

Recovery from UV-induced potentially lethal damage in systemic lupus erythematosus skin fibroblasts

Energy Technology Data Exchange (ETDEWEB)

Zamansky, G B

1986-08-01

The repair of ultraviolet light-induced potentially lethal damage was investigated in density-inhibited skin fibroblast cell strains derived from patients with systemic lupus erythematosus. The effect of exposure to polychromatic ultraviolet light composed of environmentally relevant wavelengths or to the more commonly studied, short wavelength (254 nm) ultraviolet light was studied. Systemic lupus erythematosus cells, which are hypersensitive to ultraviolet light under growth promoting conditions, were able to repair potentially lethal damage as well as normal cells.

Recovery from UV-induced potentially lethal damage in systemic lupus erythematosus skin fibroblasts

International Nuclear Information System (INIS)

Zamansky, G.B.

1986-01-01

The repair of ultraviolet light-induced potentially lethal damage was investigated in density-inhibited skin fibroblast cell strains derived from patients with systemic lupus erythematosus. The effect of exposure to polychromatic ultraviolet light composed of environmentally relevant wavelengths or to the more commonly studied, short wavelength (254 nm) ultraviolet light was studied. Systemic lupus erythematosus cells, which are hypersensitive to ultraviolet light under growth promoting conditions, were able to repair potentially lethal damage as well as normal cells. (author)

MRI changes in the central nervous system in a child with lupus erythematosus

International Nuclear Information System (INIS)

Gieron, M.A.; Khoromi, S.; Campos, A.

1995-01-01

We report on a 10-year-old girl with systemic lupus erythematosus who presented in status epilepticus as the only manifestation of central nervous system involvement. MRI of the brain showed diffuse gray and white matter lesions which almost completely resolved after treatment with methylprednisolone. MRI findings in this child are similar to those in adults with diffuse clinical manifestations. The study is essential in the initial evaluation of patients suspected of central nervous system lupus. (orig.)

MRI changes in the central nervous system in a child with lupus erythematosus

Energy Technology Data Exchange (ETDEWEB)

Gieron, M A [Dept. of Pediatrics, Univ. of South Florida, Coll. of Medicine, Tampa, FL (United States); Khoromi, S [Dept. of Neurology, Univ. of South Florida, Coll. of Medicine, Tampa, FL (United States); Campos, A [Dept. of Pediatrics, Univ. of South Florida, Coll. of Medicine, Tampa, FL (United States)

1995-05-01

We report on a 10-year-old girl with systemic lupus erythematosus who presented in status epilepticus as the only manifestation of central nervous system involvement. MRI of the brain showed diffuse gray and white matter lesions which almost completely resolved after treatment with methylprednisolone. MRI findings in this child are similar to those in adults with diffuse clinical manifestations. The study is essential in the initial evaluation of patients suspected of central nervous system lupus. (orig.)

Prevention of reproductive losses in women with systemic lupus erythematosus

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Davydova Iu.

2017-01-01

Full Text Available Purpose — to explore the peculiarities of pregnancy and childbirth in women with systemic lupus erythematosus in view of pregravid preparation. Patients and methods. The study included three groups. I group — 24 pregnant women with systemic lupus erythematosus who received pregravid preparation, group II of 28 pregnant women with systemic lupus erythematosus, have spontaneously pregnancy, III — control group 28 pregnant women without autoimmune diseases. Groups comparable in age, education, eating habits and living in similar climatic conditions. In pregravid preparations include micronized progesterone (utrozhestan in a daily dose of 200 mg of 16 to 25 days of the cycle when detecting failure II cycle phase — Tivortin in therapeutic dosage, drug containing iodine and folic acid at daily dosages recommended by WHO for preconception period (respectively, 200 mg and 400 mg. Results. In all three groups there were no spontaneous termination of pregnancy up to 12 weeks. In the first group shows significantly better results when comparing the frequency of pregnancy complications, pregnancy outcomes, metabolic disorders. Conduct prevention of endothelial dysfunction drug Tivortin and continued therapy support L-arginine in the early stages of gestation, in groups of pregnant women with high titers of anti-Ro antibodies, antiphospholipid antibodies, along with prolonged intake of micronized progesterone (utrozhestan, helped to reduce the incidence of hypertensive complications of pregnancy (gestational hypertension, pre!eclampsia and the birth of children with IUGR or low birth weight for gestational age. Group II women were not able to modify the drug therapy. Pregnant women in this group were receiving corticosteroids due to activation of an autoimmune disease. In some women was the need to enhance the treatment of SLE with corticosteroids in pulse mode using a 2-line therapy in the postpartum period. Conclusions. Pregnancy in women with

Clinical features of patients with systemic lupus erythematosus (SLE ...

African Journals Online (AJOL)

of this study was to determine the most common features of patients with systemic lupus erythematosus ... Conclusion: Most of the findings correlate with similar studies worldwide. .... Sciences, University of the Free State to conduct the study.

El Parque de los Colores

OpenAIRE

Gómez Raby,Alfonso

2006-01-01

La revisión que un arquitecto chileno hace de este proyecto de Miralles se detiene en aspectos fundamentales de la arquitectura contemporánea: vínculos declarados con el arte, indiscutible dimensión social de proyecto y coexistencia de referentes tan distantes como Miguel Angel y el graffiti urbano.

Ser padre fuera de la familia: subjetividad y vínculos de varones padres que ya no viven con sus hijos

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Genoveva Echeverría Gálvez

2012-01-01

Full Text Available La reflexión teórica toma elementos de los estudios de las masculinidades, así como desde una mirada desde la cultura y sus discursos acerca de las subjetividades y los vínculos actuales. En este contexto la familia -como constructo y como materialidad- cobra gran relevancia. En este caso las preguntas se orientaron a conocer las construcciones de subjetividades de varones que están actualmente separados, pero mantienen relaciones con sus hijos. Se realizaron entrevistas en profundidad a 10 hombres chilenos adultos, y luego se aplicó la técnica de análisis de discursos. Los resultados y conclusiones más relevantes apuntan que el ser varón es un lugar de tensión, situación que se vuelve más compleja al estar ellos fuera del marco familiar. El imaginario de familia nuclear sigue operando en ellos y les dificulta la valoración de sus nuevos vínculos y experiencias.

Definition and initial validation of a Lupus Low Disease Activity State (LLDAS).

Science.gov (United States)

Franklyn, Kate; Lau, Chak Sing; Navarra, Sandra V; Louthrenoo, Worawit; Lateef, Aisha; Hamijoyo, Laniyati; Wahono, C Singgih; Chen, Shun Le; Jin, Ou; Morton, Susan; Hoi, Alberta; Huq, Molla; Nikpour, Mandana; Morand, Eric F

2016-09-01

Treating to low disease activity is routine in rheumatoid arthritis, but no comparable goal has been defined for systemic lupus erythematosus (SLE). We sought to define and validate a Lupus Low Disease Activity State (LLDAS). A consensus definition of LLDAS was generated using Delphi and nominal group techniques. Criterion validity was determined by measuring the ability of LLDAS attainment, in a single-centre SLE cohort, to predict non-accrual of irreversible organ damage, measured using the Systemic Lupus International Collaborating Clinics Damage Index (SDI). Consensus methodology led to the following definition of LLDAS: (1) SLE Disease Activity Index (SLEDAI)-2K ≤4, with no activity in major organ systems (renal, central nervous system (CNS), cardiopulmonary, vasculitis, fever) and no haemolytic anaemia or gastrointestinal activity; (2) no new lupus disease activity compared with the previous assessment; (3) a Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA)-SLEDAI physician global assessment (scale 0-3) ≤1; (4) a current prednisolone (or equivalent) dose ≤7.5 mg daily; and (5) well tolerated standard maintenance doses of immunosuppressive drugs and approved biological agents. Achievement of LLDAS was determined in 191 patients followed for a mean of 3.9 years. Patients who spent greater than 50% of their observed time in LLDAS had significantly reduced organ damage accrual compared with patients who spent less than 50% of their time in LLDAS (p=0.0007) and were significantly less likely to have an increase in SDI of ≥1 (relative risk 0.47, 95% CI 0.28 to 0.79, p=0.005). A definition of LLDAS has been generated, and preliminary validation demonstrates its attainment to be associated with improved outcomes in SLE. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/