WorldWideScience

Sample records for children sufficiently apply

  1. Children's Sleep Needs: Is There Sufficient Evidence to Recommend Optimal Sleep for Children?

    OpenAIRE

    Matricciani, Lisa; Blunden, Sarah; Rigney, Gabrielle; Williams, Marie T.; Olds, Tim S.

    2013-01-01

    It is widely recognized that sleep is important for children's health and well-being and that short sleep duration is associated with a wide range of negative health outcomes. Recently, there has been much interest in whether or not there are sufficient data to support the specific recommendations made for how much sleep children need. In this article we explore concepts related to children's sleep need, discuss the theory, rationale, and empirical evidence for contemporary sleep recommendati...

  2. Do dietary supplements improve micronutrient sufficiency in children and adolescents?

    Science.gov (United States)

    Bailey, Regan L; Fulgoni, Victor L; Keast, Debra R; Lentino, Cindy V; Dwyer, Johanna T

    2012-11-01

    To examine if children use supplements to fill gaps in nutritionally inadequate diets or whether supplements contribute to already adequate or excessive micronutrient intakes from foods. Data were analyzed for children (2-18 years) from the National Health and Nutrition Examination Survey 2003-2006, a nationally representative, cross-sectional survey (n = 7250). Diet was assessed using two 24-hour recalls, and dietary supplement use was assessed with a 30-day questionnaire. Prevalence of supplements use was 21% (vitamin D intakes were low for all children. Inadequate intakes of phosphorus, copper, selenium, folate, and vitamins B-6 and B-12 were minimal from foods alone among 2-8 year olds. However, among 9-18 year olds, a higher prevalence of inadequate intakes of magnesium, phosphorus, and vitamins A, C, and E were observed. Supplement use increased the likelihood of intakes above the upper tolerable intake level for iron, zinc, copper, selenium, folic acid, and vitamins A and C. Even with the use of supplements, more than a one-third of children failed to meet calcium and vitamin D recommendations. Children 2-8 years old had nutritionally adequate diets regardless of supplement use. However, in children older than 8 years, dietary supplements added micronutrients to diets that would have otherwise been inadequate for magnesium, phosphorus, vitamins A, C, and E. Supplement use contributed to the potential for excess intakes of some nutrients. These findings may have implications for reformulating dietary supplements for children. Published by Mosby, Inc.

  3. Do dietary supplements improve micronutrient sufficiency in children and adolescents?

    Science.gov (United States)

    Bailey, Regan L.; Fulgoni, Victor L.; Keast, Debra R.; Lentino, Cindy V.; Dwyer, Johanna T.

    2012-01-01

    Objective To examine if children use supplements to fill gaps in nutritionally inadequate diets or whether supplements contribute to already adequate or excessive micronutrient intakes from foods. Study design Data were analyzed for children (2–18 y) from the NHANES 2003–2006, a nationally representative, cross-sectional survey (n=7,250). Diet was assessed using two 24-hour recalls, and dietary supplement use was assessed with a 30-day questionnaire. Results Prevalence of supplements use was 21% (Supplement users had higher micronutrient intakes than nonusers. Calcium and vitamin D intakes were low for all children. Inadequate intakes of phosphorus, copper, selenium, folate, and vitamins B-6 and B-12 were minimal from foods alone among 2–8 y olds. However, among 9–18 y olds, a higher prevalence of inadequate intakes of magnesium, phosphorus, and vitamins A, C, and E were observed. Supplement use increased the likelihood of intakes above the Upper Tolerable Intake Level for iron, zinc, copper, selenium, folic acid, and vitamins A and C. Conclusions Even with the use of supplements, more than a one-third of children failed to meet calcium and vitamin D recommendations. Children 2–8 y had nutritionally adequate diets regardless of supplement use. However, in children older than 8 y dietary supplements added micronutrients to diets that would have otherwise been inadequate for magnesium, phosphorus, vitamins A,C, and E. Supplement use contributed to the potential for excess intakes of some nutrients. These findings may have implications for reformulating dietary supplements for children. PMID:22717218

  4. The Effects of Simple Necessity and Sufficiency Relationships on Children's Causal Inferences

    Science.gov (United States)

    Siegler, Robert S.

    1976-01-01

    Attempted to determine (1) whether developmental differences existed in children's comprehension of simple necessity and simple sufficiency relationships, and (2) the source of developmental differences in children's causal reasoning. (SB)

  5. Children's sleep needs: is there sufficient evidence to recommend optimal sleep for children?

    Science.gov (United States)

    Matricciani, Lisa; Blunden, Sarah; Rigney, Gabrielle; Williams, Marie T; Olds, Tim S

    2013-04-01

    It is widely recognized that sleep is important for children's health and well-being and that short sleep duration is associated with a wide range of negative health outcomes. Recently, there has been much interest in whether or not there are sufficient data to support the specific recommendations made for how much sleep children need. In this article we explore concepts related to children's sleep need, discuss the theory, rationale, and empirical evidence for contemporary sleep recommendations, and outline future research directions for sleep recommendations. If sleep is to be treated as a therapeutic intervention, then consensus guidelines, statements, and evidence-based best-practice documents are needed to underpin sleep recommendations for children.

  6. Sufficient Social Support as a Possible Preventive Factor against Fighting and Bullying in School Children.

    Science.gov (United States)

    Šmigelskas, Kastytis; Vaičiūnas, Tomas; Lukoševičiūtė, Justė; Malinowska-Cieślik, Marta; Melkumova, Marina; Movsesyan, Eva; Zaborskis, Apolinaras

    2018-04-26

    Background: This study aims to explore how sufficient social support can act as a possible preventive factor against fighting and bullying in school-aged children in 9 European countries. Methods : Data for this study were collected during the 2013/2014 Health Behaviour in School-aged Children (HBSC) survey. The sample consisted of 9 European countries, involving 43,667 school children in total, aged 11, 13 and 15 years. The analysed data focus on social context (relations with family, peers, and school) as well as risk behaviours such as smoking, drunkenness, fighting and bullying in adolescents. The relationships between social support and violent behaviour variables were estimated using multiple regression models and multivariate analyses. Results : Bullying, across 9 countries, was more prevalent than fighting, except for Armenia, Israel, and Poland. The prevalence among countries differed considerably, with fighting being most expressed in Armenia and bullying—in Latvia and Lithuania. The strongest risk factors for bullying and fighting were male gender (less expressed for bullying), smoking and alcohol consumption. In addition, for bullying the social support was similarly strong factor like above-mentioned factors, while for fighting—less significant, but still independent. All forms of social support were significantly relate with lower violent behaviour of school children, and family support was associated most strongly. Regardless the socioeconomic, historical, and cultural differences among selected countries, the enhancement and reinforcement of the social support from possible many different resources should be taken into consideration in prevention programs against school violence behaviours.

  7. Sufficient Social Support as a Possible Preventive Factor against Fighting and Bullying in School Children

    Directory of Open Access Journals (Sweden)

    Kastytis Šmigelskas

    2018-04-01

    Full Text Available Background: This study aims to explore how sufficient social support can act as a possible preventive factor against fighting and bullying in school-aged children in 9 European countries. Methods: Data for this study were collected during the 2013/2014 Health Behaviour in School-aged Children (HBSC survey. The sample consisted of 9 European countries, involving 43,667 school children in total, aged 11, 13 and 15 years. The analysed data focus on social context (relations with family, peers, and school as well as risk behaviours such as smoking, drunkenness, fighting and bullying in adolescents. The relationships between social support and violent behaviour variables were estimated using multiple regression models and multivariate analyses. Results: Bullying, across 9 countries, was more prevalent than fighting, except for Armenia, Israel, and Poland. The prevalence among countries differed considerably, with fighting being most expressed in Armenia and bullying—in Latvia and Lithuania. The strongest risk factors for bullying and fighting were male gender (less expressed for bullying, smoking and alcohol consumption. In addition, for bullying the social support was similarly strong factor like above-mentioned factors, while for fighting—less significant, but still independent. All forms of social support were significantly relate with lower violent behaviour of school children, and family support was associated most strongly. Regardless the socioeconomic, historical, and cultural differences among selected countries, the enhancement and reinforcement of the social support from possible many different resources should be taken into consideration in prevention programs against school violence behaviours.

  8. Analysing Children's Drawings: Applied Imagination

    Science.gov (United States)

    Bland, Derek

    2012-01-01

    This article centres on a research project in which freehand drawings provided a richly creative and colourful data source of children's imagined, ideal learning environments. Issues concerning the analysis of the visual data are discussed, in particular, how imaginative content was analysed and how the analytical process was dependent on an…

  9. Are children's dental panoramic tomographs and lateral cephalometric radiographs sufficiently optimized?

    Science.gov (United States)

    Pakbaznejad Esmaeili, Elmira; Ekholm, Marja; Haukka, Jari; Evälahti, Marjut; Waltimo-Sirén, Janna

    2016-02-01

    Children are especially vulnerable to harmful effects of ionizing radiation. Cutting down the dimensions of the X-ray beam is the most effective way to reduce the patient dose. We evaluated the appropriateness of field-size in the most frequent radiographs, dental panoramic tomographs (DPTs) and lateral cephalometric radiographs (LCRs) among 7- to 12-year-olds. The image field-size of 241 DPTs and 118 LCRs was analysed. The image field was considered appropriate when it did not include anatomic structures beyond the area of clinical interest. The image field was compared with factors such as the age of the patient, the radiographic equipment used and the programme selected. Moreover, we assessed the use of thyroid shield in LCR. The field-size was too large in 70% of the DPTs horizontally and in 96% vertically. None of the DPTs were segmented. Every LCR showed appropriate limitation anteriorly, but the image field was too large in 54% posteriorly, in 86% superiorly, and in 76% inferiorly. A thyroid shield had been used in only 71% of cases. Most DPTs and LCRs had been performed sub-optimally. An abundancy of DPTs had been taken using an adult programme, and the field-size had not been sufficiently adjusted in LCRs, possibly for technical reasons. To facilitate adherence to radiological best practice the equipment used for DPTs and LCRs should facilitate the adjustment of field-size in both the vertical and horizontal planes. In addition, those involved in taking radiographs should maintain their skills through regular update courses. © The Author 2015. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  10. Determinants of 25(OH)D sufficiency in obese minority children: selecting outcome measures and analytic approaches.

    Science.gov (United States)

    Zhou, Ping; Schechter, Clyde; Cai, Ziyong; Markowitz, Morri

    2011-06-01

    To highlight complexities in defining vitamin D sufficiency in children. Serum 25-(OH) vitamin D [25(OH)D] levels from 140 healthy obese children age 6 to 21 years living in the inner city were compared with multiple health outcome measures, including bone biomarkers and cardiovascular risk factors. Several statistical analytic approaches were used, including Pearson correlation, analysis of covariance (ANCOVA), and "hockey stick" regression modeling. Potential threshold levels for vitamin D sufficiency varied by outcome variable and analytic approach. Only systolic blood pressure (SBP) was significantly correlated with 25(OH)D (r = -0.261; P = .038). ANCOVA revealed that SBP and triglyceride levels were statistically significant in the test groups [25(OH)D 25 ng/mL]. ANCOVA also showed that only children with severe vitamin D deficiency [25(OH)D model regression analyses found evidence of a threshold level in SBP, with a 25(OH)D breakpoint of 27 ng/mL, along with a 25(OH)D breakpoint of 18 ng/mL for triglycerides, but no relationship between 25(OH)D and parathyroid hormone. Defining vitamin D sufficiency should take into account different vitamin D-related health outcome measures and analytic methodologies. Copyright © 2011 Mosby, Inc. All rights reserved.

  11. ADHD Expressive Writing Difficulties of ADHD Children: When Good Declarative Knowledge Is Not Sufficient

    Science.gov (United States)

    Re, Anna Maria; Cornoldi, Cesare

    2010-01-01

    A large body of evidence shows that many of the academic difficulties Attention Deficit Hyperactivity Disorder (ADHD) children have may be related to their problems in executive control. However, the particular case of expressive writing has not been deeply explored. The present study examines the typical school exercise of writing a letter.…

  12. Is the frontal radiograph alone sufficient to evaluate for pneumonia in children?

    International Nuclear Information System (INIS)

    Rigsby, Cynthia K.; Strife, Janet L.; Johnson, Neil D.; Atherton, Harry D.; Kotagal, Uma R.; Pommersheim, William

    2004-01-01

    In our cost- and radiation-conscious environment, the feasibility of performing only a frontal radiograph for the diagnosis of pneumonia in children needs to be reassessed. To determine the diagnostic efficacy of the frontal radiograph alone in comparison to the frontal and lateral combined radiographs for the radiographic diagnosis of pneumonia in children. Three radiologists retrospectively and independently reviewed the frontal radiographs alone and separately reviewed the frontal and lateral radiographs of 1,268 children referred from the emergency room for chest radiographs. A majority interpretation of at least two radiologists for the frontal views alone was compared with majority interpretation of the frontal and lateral combined views for the radiographic diagnosis of pneumonia. ''Pneumonia'' was defined as a focus of streaky or confluent lung opacity. For the radiographic diagnosis of pneumonia, the sensitivity and specificity of the frontal view alone were 85% and 98%, respectively. For the confluent lobar type of pneumonia, the sensitivity and specificity increased to 100%. When the frontal view alone yields a diagnosis of confluent lobar pneumonia, this is highly reliable. However, nonlobar types of infiltrates will be underdiagnosed in 15% of patients using the frontal view alone. The clinical impact of these radiographically underdiagnosed pneumonias needs to be assessed prior to implementing the practice of using only frontal radiographs for diagnosing pneumonia. (orig.)

  13. Is the frontal radiograph alone sufficient to evaluate for pneumonia in children?

    Energy Technology Data Exchange (ETDEWEB)

    Rigsby, Cynthia K. [Department of Radiology, Children' s Hospital Medical Center, 3333 Burnet Avenue, OH 45229, Cincinnati (United States); Department of Medical Imaging No. 9, Children' s Memorial Hospital, 2300 Children' s Plaza, IL 60614, Chicago (United States); Strife, Janet L.; Johnson, Neil D. [Department of Radiology, Children' s Hospital Medical Center, 3333 Burnet Avenue, OH 45229, Cincinnati (United States); Atherton, Harry D.; Kotagal, Uma R. [Department of Health Policy and Clinical Effectiveness, Children' s Hospital Medical Center, 3333 Burnet Avenue, OH 45229, Cincinnati (United States); Pommersheim, William [Department of Radiology, Children' s Hospital Medical Center, 3333 Burnet Avenue, OH 45229, Cincinnati (United States); Wake Forest University Baptist Medical Center, Department of Radiology, Meads Hall, 2nd Floor, NC 27157, Winston-Salem (United States)

    2004-05-01

    In our cost- and radiation-conscious environment, the feasibility of performing only a frontal radiograph for the diagnosis of pneumonia in children needs to be reassessed. To determine the diagnostic efficacy of the frontal radiograph alone in comparison to the frontal and lateral combined radiographs for the radiographic diagnosis of pneumonia in children. Three radiologists retrospectively and independently reviewed the frontal radiographs alone and separately reviewed the frontal and lateral radiographs of 1,268 children referred from the emergency room for chest radiographs. A majority interpretation of at least two radiologists for the frontal views alone was compared with majority interpretation of the frontal and lateral combined views for the radiographic diagnosis of pneumonia. ''Pneumonia'' was defined as a focus of streaky or confluent lung opacity. For the radiographic diagnosis of pneumonia, the sensitivity and specificity of the frontal view alone were 85% and 98%, respectively. For the confluent lobar type of pneumonia, the sensitivity and specificity increased to 100%. When the frontal view alone yields a diagnosis of confluent lobar pneumonia, this is highly reliable. However, nonlobar types of infiltrates will be underdiagnosed in 15% of patients using the frontal view alone. The clinical impact of these radiographically underdiagnosed pneumonias needs to be assessed prior to implementing the practice of using only frontal radiographs for diagnosing pneumonia. (orig.)

  14. Sleep and memory in the making. Are current concepts sufficient in children?

    Science.gov (United States)

    Peigneux, P

    2014-01-01

    Memory consolidation is an active process wired in brain plasticity. How plasticity mechanisms develop and are modulated after learning is at the core of current models of sleep-dependent memory consolidation. Nowadays, two main classes of sleep-related memory consolidation theories are proposed, namely system consolidation and synaptic homeostasis. However, novel models of consolidation emerge, that might better account for the highly dynamic and interactive processes of encoding and memory consolidation. Processing steps can take place at various temporal phases and be modulated by interactions with prior experiences and ongoing events. In this perspective, sleep might support (or not) memory consolidation processes under specific neurophysiological and environmental circumstances leading to enduring representations in long-term memory stores. We outline here a discussion about how current and emergent models account for the complexity and apparent inconsistency of empirical data. Additionally, models aimed at understanding neurophysiological and/or cognitive processes should not only provide a satisfactory explanation for the phenomena at stake, but also account for their ontogeny and the conditions that disrupt their organisation. Looking at the available literature, this developmental condition appears to remain unfulfilled when trying to understand the relationships between sleep, learning and memory consolidation processes, both in healthy children and in children with pathological conditions.

  15. Inhaled corticosteroid treatment for 6 months was not sufficient to normalize phagocytosis in asthmatic children.

    Science.gov (United States)

    da Silva-Martins, Carmen Lívia Faria; Couto, Shirley Claudino; Muniz-Junqueira, Maria Imaculada

    2013-08-30

    Corticosteroids are the first-line therapy for asthma; however, the effect of corticosteroids on the innate immune system remains unclear. This study's objective was to evaluate the effect of inhaled corticosteroid therapy (ICT) on phagocytic functions. To evaluate the impact of ICT, the phagocytosis of Saccharomyces cerevisiae by blood monocytes and neutrophils and the production of superoxide anions were assessed before and after three and six months of ICT treatment in 58 children with persistent asthma and 21 healthy controls. We showed that the phagocytic capacity of monocytes and neutrophils that occurred via pattern recognition receptors or was mediated by complement and immunoglobulin receptors in asthmatic children before treatment was significantly lower than in healthy controls (pICT for 6 months was not sufficient to normalize phagocytosis by the phagocytes. Superoxide anion production was also decreased in the asthmatic children before treatment, and ICT normalized the O- production only for children with mild persistent asthma when assessed at baseline but caused this function to decrease after stimulation (p<0.05, Kruskal-Wallis test). Our data suggest that an immunodeficiency in phagocytes remained even after treatment. However, this immunodeficiency does not appear to correspond with the clinical evolution of asthma because an improvement in clinical parameters occurred.

  16. Is Inferior Alveolar Nerve Block Sufficient for Routine Dental Treatment in 4- to 6-year-old Children?

    Science.gov (United States)

    Pourkazemi, Maryam; Erfanparast, Leila; Sheykhgermchi, Sanaz; Ghanizadeh, Milad

    2017-01-01

    Pain control is one of the most important aspects of behavior management in children. The most common way to achieve pain control is by using local anesthetics (LA). Many studies describe that the buccal nerve innervates the buccal gingiva and mucosa of the mandible for a variable extent from the vicinity of the lower third molar to the lower canine. Regarding the importance of appropriate and complete LA in child-behavior control, in this study, we examined the frequency of buccal gingiva anesthesia of primary mandibular molars and canine after inferior alveolar nerve block injection in 4- to 6-year-old children. In this descriptive cross-sectional study, 220 4- to 6-year-old children were randomly selected and entered into the study. Inferior alveolar nerve block was injected with the same method and standards for all children, and after ensuring the success of block injection, anesthesia of buccal mucosa of primary molars and canine was examined by stick test and reaction of child using sound, eye, motor (SEM) scale. The data from the study were analyzed using descriptive statistics and statistical software Statistical Package for the Social Sciences (SPSS) version 21. The area that was the highest nonanesthetized was recorded as in the distobuccal of the second primary molars. The area of the lowest nonanesthesia was also reported in the gingiva of primary canine tooth. According to this study, in 15 to 30% of cases, after inferior alveolar nerve block injection, the primary mandibular molars' buccal mucosa is not anesthetized. How to cite this article: Pourkazemi M, Erfanparast L, Sheykhgermchi S, Ghanizadeh M. Is Inferior Alveolar Nerve Block Sufficient for Routine Dental Treatment in 4- to 6-year-old Children? Int J Clin Pediatr Dent 2017;10(4):369-372.

  17. "Are Thai children and youth sufficiently active? prevalence and correlates of physical activity from a nationally representative cross-sectional study".

    Science.gov (United States)

    Amornsriwatanakul, Areekul; Lester, Leanne; Bull, Fiona C; Rosenberg, Michael

    2017-05-30

    Children and youth gain multiple health benefits from regular participation in physical activity (PA). However, in Thailand there is limited national data on children and youth's PA behaviors and recent reports suggest that Thai children and youth have low levels of PA. Furthermore, there is almost no data on the factors associated with inactivity to support the development of a Thai National PA Plan. The purpose of this paper is to investigate Thai children and youth's participation in PA and its correlates across sociodemographic characteristics and different PA domains. This study applied a cross-sectional study design with a multi-stage stratified cluster sampling. A national representative sample of 13,255 children and youth aged 6-17 years were used for data analysis. A previously validated questionnaire was used to assess PA prevalence. Logistic regression was conducted to examine the relationships of socio-demographic factors, and participation in different PA domains with overall PA. Only 23.4% of Thai children and youth met recommended levels of PA and there were large gender and regional differences. PA levels generally declined with age, although the level observed in the 10-13 year group was slightly higher than other year groups. A majority of children and youth engaged in a large number of different activities across PA domains. Sex, age, BMI, geographical regions, organized sports, participation in sport and recreational activities were significant predictors of meeting the global PA guidelines, whereas participation in physical education, active transport, and the number of screen time activities had no association. Girls were less likely to achieve sufficient PA levels (OR = 0.49, 95%CI; 0.45-0.54, p Thai children and youth is low, despite the high levels of engagement in a large number of PA. The results indicate that policy and interventions aimed at increasing PA are needed with special attention required to address specific groups less

  18. Hypoxic challenge test applied to healthy children

    DEFF Research Database (Denmark)

    Kobbernagel, Helene Elgaard; Nielsen, Kim Gjerum; Hanel, Birgitte

    2013-01-01

    BACKGROUND: Commercial aircraft are pressurised to ~2438 m (8000 ft) above sea level that equates breathing 15% oxygen at sea level. A preflight hypoxic challenge test (HCT) is therefore recommended for children with cystic fibrosis or other chronic lung diseases and inflight oxygen is advised if...

  19. Maternal urinary iodine concentration in pregnancy and children's cognition: results from a population-based birth cohort in an iodine-sufficient area

    NARCIS (Netherlands)

    Ghassabian, A.; Steenweg- de Graaff, J.; Peeters, R.P.; Ross, H.A.; Jaddoe, V.W.; Hofman, A.; Verhulst, F.C.; White, T.; Tiemeier, H.

    2014-01-01

    OBJECTIVE: Reports from populations with an insufficient iodine intake suggest that children of mothers with mild iodine deficiency during pregnancy are at risk for cognitive impairments. However, it is unknown whether, even in iodine-sufficient areas, low levels of iodine intake occur that

  20. RESULTS OF APPLYING POLYVITAMIN COMPLEX FOR CHILDREN WITH ATOPIC DERMATITIS

    Directory of Open Access Journals (Sweden)

    N.A. Ivanova

    2007-01-01

    Full Text Available The article presents findings of applying vitamin-and-mineral complex (VMC for children frequently suffering from diseases and children with atopic dermatitis. It shows that usage of VMC within a complex therapy promotes regression of subnormal vitamin provision symptoms, as well as symptoms of the core disease. This happens against heightened vitamin content in child's organism — which was proven with the test of A and E vitamins content in blood. The research has demonstrated a quite good tolerance of VMC by children suffering from atopic dermatitis.Key words: children frequently suffering from diseases, atopic dermatitis, vitamins, treatment.

  1. Urinary Iodine Concentrations Indicate Iodine Deficiency in Pregnant Thai Women but Iodine Sufficiency in Their School-Aged Children

    NARCIS (Netherlands)

    Gowachirapant, S.; Winichagoon, P.; Wyss, L.; Tong, B.; Baumgartner, J.; Boonstra, A.; Zimmermann, M.B.

    2009-01-01

    The median urinary iodine concentration (UI) in school-aged children is recommended for assessment of iodine nutrition in populations. If the median UI is adequate in school-aged children, it is usually assumed iodine intakes are also adequate in the remaining population, including pregnant women.

  2. Clinical and Biochemical Parameters of Children and Adolescents Applying Pesticides

    Directory of Open Access Journals (Sweden)

    A Ismail

    2010-06-01

    Full Text Available Background: The primary agricultural product in Egypt is the cotton crop. Children and adolescents work seasonally in the cotton fields applying pesticides. Objectives: To examine the effect of pesticide exposure on clinical and biochemical parameters in children and adolescents applying pesticides. Methods: Male children currently applying pesticides and aged between 9 and 19 years (n = 50 were recruited for this study. They were asked to complete work, health, and exposure questionnaires; examined for any medical and neurological problems with particular attention to sensory and motor functions including cranial nerves, sensory and motor system, and reflexes. From each participant, a blood sample was taken to measure acetylcholinesterase activity, and liver and kidney functions. Children who have never worked in agriculture (n = 50, matched on age, education, and socioeconomic status were also studied and served as controls. Results: More neuromuscular disorders were identified in pesticide applicators than controls. A significant lower level of acetylcholinesterase was found in the applicator group compared to the controls. There was also a significant difference in hematological, renal and hepatic indices in the exposed children compared to the control children. Working more days in the current season and also working more years as a pesticide applicator were both associated with an increase in the prevalence of neuromuscular abnormalities and significant changes in the laboratory tests. Conclusion: Children and adolescent pesticide applicators working in farms of Egypt are at risk of developing serious health problems similar to those of adults.

  3. Do parents' support behaviours predict whether or not their children get sufficient sleep? A cross-sectional study.

    Science.gov (United States)

    Pyper, Evelyn; Harrington, Daniel; Manson, Heather

    2017-05-24

    Sleep is an essential component of healthy cognitive and physical development. Lack of sleep may put children at risk for a variety of mental and physical health outcomes, including overweight, obesity and related chronic diseases. Given that children's sleep duration has decreased in recent decades, there is a need to understand the determinants of child sleep, including the role of parental support behaviours. This study aims to determine the relative contribution of different types of parental support behaviours for predicting the likelihood that children meet recently established Canadian sleep guidelines. Data were collected using Computer Assisted Telephone Interviews (CATI) of parents or guardians with at least one child under the age of 18 living in Ontario, Canada. To align with sleep guidelines, parents included in this analysis had at least one child between 5 and 17 years of age (n = 1622). Two multivariable logistic regression models were built to predict whether or not parents reported their child was meeting sleep guidelines - one for weekday sleep and another for sleep on weekends. Independent variables included parent and child age and gender, motivational and regulatory parental support behaviours, and socio-demographic characteristics. On weekdays, enforcing rules about child bedtime was a significant positive predictor of children meeting sleep guidelines (OR: 1.59; 95% CI: 1.03-2.44); while encouraging the child to go to bed at a specific time was a significant negative predictor of child meeting sleep guidelines (OR: 0.29; 95% CI: 0.13-0.65). On weekends, none of the parental support behaviours contributed significantly to the predictions of child sleep. For both weekdays and weekends, the child's age group was an important predictor of children meeting sleep guidelines. The contribution of parental support behaviours to predictions of children meeting sleep guidelines varied with the type of support provided, and weekend versus weekday

  4. Do parents’ support behaviours predict whether or not their children get sufficient sleep? A cross-sectional study

    Directory of Open Access Journals (Sweden)

    Evelyn Pyper

    2017-05-01

    Full Text Available Abstract Background Sleep is an essential component of healthy cognitive and physical development. Lack of sleep may put children at risk for a variety of mental and physical health outcomes, including overweight, obesity and related chronic diseases. Given that children’s sleep duration has decreased in recent decades, there is a need to understand the determinants of child sleep, including the role of parental support behaviours. This study aims to determine the relative contribution of different types of parental support behaviours for predicting the likelihood that children meet recently established Canadian sleep guidelines. Methods Data were collected using Computer Assisted Telephone Interviews (CATI of parents or guardians with at least one child under the age of 18 living in Ontario, Canada. To align with sleep guidelines, parents included in this analysis had at least one child between 5 and 17 years of age (n = 1622. Two multivariable logistic regression models were built to predict whether or not parents reported their child was meeting sleep guidelines – one for weekday sleep and another for sleep on weekends. Independent variables included parent and child age and gender, motivational and regulatory parental support behaviours, and socio-demographic characteristics. Results On weekdays, enforcing rules about child bedtime was a significant positive predictor of children meeting sleep guidelines (OR: 1.59; 95% CI: 1.03–2.44; while encouraging the child to go to bed at a specific time was a significant negative predictor of child meeting sleep guidelines (OR: 0.29; 95% CI: 0.13–0.65. On weekends, none of the parental support behaviours contributed significantly to the predictions of child sleep. For both weekdays and weekends, the child’s age group was an important predictor of children meeting sleep guidelines. Conclusions The contribution of parental support behaviours to predictions of children meeting sleep

  5. Auditory processing deficits are sometimes necessary and sometimes sufficient for language difficulties in children: Evidence from mild to moderate sensorineural hearing loss.

    Science.gov (United States)

    Halliday, Lorna F; Tuomainen, Outi; Rosen, Stuart

    2017-09-01

    There is a general consensus that many children and adults with dyslexia and/or specific language impairment display deficits in auditory processing. However, how these deficits are related to developmental disorders of language is uncertain, and at least four categories of model have been proposed: single distal cause models, risk factor models, association models, and consequence models. This study used children with mild to moderate sensorineural hearing loss (MMHL) to investigate the link between auditory processing deficits and language disorders. We examined the auditory processing and language skills of 46, 8-16year-old children with MMHL and 44 age-matched typically developing controls. Auditory processing abilities were assessed using child-friendly psychophysical techniques in order to obtain discrimination thresholds. Stimuli incorporated three different timescales (µs, ms, s) and three different levels of complexity (simple nonspeech tones, complex nonspeech sounds, speech sounds), and tasks required discrimination of frequency or amplitude cues. Language abilities were assessed using a battery of standardised assessments of phonological processing, reading, vocabulary, and grammar. We found evidence that three different auditory processing abilities showed different relationships with language: Deficits in a general auditory processing component were necessary but not sufficient for language difficulties, and were consistent with a risk factor model; Deficits in slow-rate amplitude modulation (envelope) detection were sufficient but not necessary for language difficulties, and were consistent with either a single distal cause or a consequence model; And deficits in the discrimination of a single speech contrast (/bɑ/ vs /dɑ/) were neither necessary nor sufficient for language difficulties, and were consistent with an association model. Our findings suggest that different auditory processing deficits may constitute distinct and independent routes to

  6. Do sufficient vitamin D levels at the end of summer in children and adolescents provide an assurance of vitamin D sufficiency at the end of winter? A cohort study.

    Science.gov (United States)

    Shakeri, Habibesadat; Pournaghi, Seyed-Javad; Hashemi, Javad; Mohammad-Zadeh, Mohammad; Akaberi, Arash

    2017-10-26

    The changes in serum 25-hydroxyvitamin D (25(OH)D) in adolescents from summer to winter and optimal serum vitamin D levels in the summer to ensure adequate vitamin D levels at the end of winter are currently unknown. This study was conducted to address this knowledge gap. The study was conducted as a cohort study. Sixty-eight participants aged 7-18 years and who had sufficient vitamin D levels at the end of the summer in 2011 were selected using stratified random sampling. Subsequently, the participants' vitamin D levels were measured at the end of the winter in 2012. A receiver operating characteristic (ROC) curve was used to determine optimal cutoff points for vitamin D at the end of the summer to predict sufficient vitamin D levels at the end of the winter. The results indicated that 89.7% of all the participants had a decrease in vitamin D levels from summer to winter: 14.7% of them were vitamin D-deficient, 36.8% had insufficient vitamin D concentrations and only 48.5% where able to maintain sufficient vitamin D. The optimal cutoff point to provide assurance of sufficient serum vitamin D at the end of the winter was 40 ng/mL at the end of the summer. Sex, age and vitamin D levels at the end of the summer were significant predictors of non-sufficient vitamin D at the end of the winter. In this age group, a dramatic reduction in vitamin D was observed over the follow-up period. Sufficient vitamin D at the end of the summer did not guarantee vitamin D sufficiency at the end of the winter. We found 40 ng/mL as an optimal cutoff point.

  7. Comparison of 72-hour fecal fat quantification and the 13C-mixed triglyceride breath test in assessing pancreatic exocrine sufficiency in children with chronic pancreatitis.

    Science.gov (United States)

    Wejnarska, Karolina; Kołodziejczyk, Elwira; Ryżko, Józef; Oracz, Grzegorz

    Chronic pancreatitis (CP) in children is still a rare, although increasingly recognized entity. Over the duration of the disease several complications can be observed, two of which are major ones: endo- and exocrine insufficiency. In the medical care of children with CP it is crucial to diagnose the decreased endo- and exocrine function of the pancreas, in order to preserve patients from malnutrition and the failure to thrive. The aim of the study was to compare the usefulness of two indirect methods of assessing the pancreas exocrine function in children with CP. Ninety one patients with CP were enrolled in the study (41 boys, 50 girls, aged 2-17.8 years). Only Patients who had had both the 72-hour fecal fat quantification and the 13C-mixed triglyceride breath test (13C -MTBT) performed were selected. We compared the results of both tests for sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) in detecting exocrine pancreatic insufficiency. Out of 91 patients, 12 were diagnosed with exocrine pancreatic insufficiency (EPI). The sensitivity of the fecal fat quantification was 50%, the specificity for the test was 100%. PPV and NPV were 100% and 93%, respectively. 13C-MTBT had the sensitivity of 42% and the specificity of 99%. PPV and NPV for the breath test were of 83% and 92%, respectively. No statistically significant discrepancy between the values obtained was found. Although the 72-hour fecal fat quantification remains the gold standard in detecting EPI, both of the methods that had been investigated were shown to be comparable regarding sensitivity, specificity, PPV and NPV in assessing pancreas exocrine sufficiency in children with CP. Due to the easier execution of the breath test, both for the patient and for medical personnel, its importance may increase.

  8. ?Are Thai children and youth sufficiently active? prevalence and correlates of physical activity from a nationally representative cross-sectional study?

    OpenAIRE

    Amornsriwatanakul, Areekul; Lester, Leanne; Bull, Fiona C.; Rosenberg, Michael

    2017-01-01

    Background Children and youth gain multiple health benefits from regular participation in physical activity (PA). However, in Thailand there is limited national data on children and youth?s PA behaviors and recent reports suggest that Thai children and youth have low levels of PA. Furthermore, there is almost no data on the factors associated with inactivity to support the development of a Thai National PA Plan. The purpose of this paper is to investigate Thai children and youth?s participati...

  9. Applying Motivational Interviewing to Counselling Overweight and Obese Children

    Science.gov (United States)

    Lindhe Soderlund, Lena; Nordqvist, Cecilia; Angbratt, Marianne; Nilsen, Per

    2009-01-01

    The aim of this study was to identify barriers and facilitators to nurses' application of motivational interviewing (MI) to counselling overweight and obese children aged 5 and 7 years, accompanied by their parents. Ten welfare centre and school health service nurses trained and practiced MI for 6 months, then participated in focus group…

  10. Strategic planning applied to quality in asthma management for children.

    Science.gov (United States)

    Goonan, K J; Healy, J M; Jordan, H S; Zazzali, J L; Horowitz, M

    1993-01-01

    This strategic plan translates the HCHP vision statement into a working plan for one major clinical condition--asthma in children. It is a working plan for clinicians and managers across specialties and levels. The results of the projects will improve in a measurable way significant clinical practice and outcomes, in keeping with the FY 1993 strategic goals.

  11. Play Therapy Applied by Parents for Children with Darkness Phobia: Comparison of Two Programmes

    Science.gov (United States)

    Santacruz, Isabel; Mendez, Francisco J.; Sanchez-Meca, Julio

    2006-01-01

    Two play therapies applied by parents for darkness phobia in young children are compared. Seventy-eight children between the ages of 4 and 8 were recruited from twenty-seven schools. The participants were randomly assigned to three experimental conditions: bibliotherapy and games, emotive performances, and no treatment. The treatments were applied…

  12. A National UK Census of Applied Behavior Analysis School Provision for Children with Autism

    Science.gov (United States)

    Griffith, G. M.; Fletcher, R.; Hastings, R. P.

    2012-01-01

    Over more than a decade, specialist Applied Behavior Analysis (ABA) schools or classes for children with autism have developed in the UK and Ireland. However, very little is known internationally about how ABA is defined in practice in school settings, the characteristics of children supported in ABA school settings, and the staffing structures…

  13. Is high dose methotrexate without irradiation of the brain sufficiently effective in prevention of CNS disease in children with acute lymphoblastic leukemia?

    International Nuclear Information System (INIS)

    Cap, J.; Foltinova, A.; Kaiserova, E.; Mojzesova, A.; Sejnova, D.; Jamarik, M.

    1998-01-01

    We present 5-year results of treatment in 93 children suffering from acute lymphoblastic leukemia using two therapeutic protocols containing multidrug chemotherapy including high dose methotrexate. We could ascertain different results in standard and high risk patients. In a group of 62 children with standard risk we observed improvement in complete remission rate being 98.9% after induction phase of therapy, only one patient died on septicemia. Relapse rate in this group was 21.2% and that 14. 7% in the bone marrow and 6.5% in CNS and no testicular relapse at all. In the group of 31 children with high risk leukemia all patients achieved complete remission. Only one of them died on acute pancreatitis due to toxicity. Overall relapse rate in this group was 28.9% with 12.8% of medullary relapse and 16.1 % of CNS relapse. The last one was significantly higher than in the previous study when brain irradiation was a part of therapeutic procedure. It seems that this treatment is effective mainly in the standard risk leukemia, however, in the high risk leukemias this procedure appears to be less effective in preventing CNS leukemia. In this group of patients irradiation of the brain need to be enclosed in the therapy. (authors)

  14. Four Weeks in a Single-Leg Weight-Bearing Hip Spica Cast is Sufficient Treatment for Isolated Femoral Shaft Fractures in Children Aged 1 to 3 Years.

    Science.gov (United States)

    Jaafar, Sami; Sobh, Ali; Legakis, Julie E; Thomas, Ronald; Buhler, Kelsey; Jones, Eric T

    2016-01-01

    Hip spica casting regimens for the treatment of femoral shaft fractures in a pediatric population aged 1 to 3 years vary. Patient charts were reviewed to determine if there are any clinical differences between 3 and 4 weeks in an ambulatory single-leg hip spica (SLHS) cast versus 6 to 8 weeks in a standard double-leg, non-weight-bearing hip spica cast. The medical records of 109 patients with femoral shaft fractures treated with a hip spica casting from January 1, 2008 to December 31, 2011 were examined. After exclusions, 94 patients were eligible for inclusion in the study. Patient records were assessed, noting age, weight, type of cast, time in cast, and complications. All casts were applied by senior pediatric orthopaedic surgeons at a single institution. Two groups were evaluated: 59 patients in the SLHS group and 35 in the double-leg hip spica group. The 2 groups were demographically similar with an average age of 2 years, 70.2% of patients were male, 45.7% were black, and 35.1% were white. The average time to cast removal was 4.1 weeks for the single-leg group and 5.3 weeks for the double-leg group (Pshaft fractures in patients less than 4 years old can be treated in a weight-bearing SLHS casts for approximately 4 weeks with fewer alignment and skin complications. Level III-clinical retrospective comparative study.

  15. A Pilot Study on the Combination of Applied Behavior Analysis and Bumetanide Treatment for Children with Autism

    NARCIS (Netherlands)

    Du, L.; Shan, L.; Wang, B.; Li, H.; Xu, Z.; Staal, W.G.; Jia, F.

    2015-01-01

    OBJECTIVE: The purpose of this study was to investigate the therapeutic effects of combined bumetanide and applied behavior analysis (ABA) treatment in children with autism. METHODS: Sixty children diagnosed with autism according to the International Classification of Diseases, Tenth Revision

  16. From "Buzzword" to Best Practice: Applying Intersectionality to Children Exposed to Intimate Partner Violence.

    Science.gov (United States)

    Etherington, Nicole; Baker, Linda

    2016-03-07

    Empirical studies on the impact of intimate partner violence (IPV) on children have burgeoned over the last three decades. Notably absent from existing approaches to studying children exposed to IPV, however, is attention to how various positionalities intersect to impact the experiences of children and their families. In fact, while the importance of an intersectional framework for understanding IPV has been discussed for over two decades, little or no attention has been given to issues of children's exposure to IPV. In this article, we examine the current state of the literature on children exposed to IPV through an exploratory meta-analysis, finding limited application of intersectionality and a focus on discrete categories of difference. We then demonstrate why and how an intersectional framework should be applied to children exposed to IPV, with specific strategies for research and policy. We suggest a child-centered approach that recognizes diversity among children exposed to IPV, extending the challenge to traditional "one-size-fits-all" models to include an intersectionality-informed stance. © The Author(s) 2016.

  17. Applying Mechatronics to Improve the Safety of Children in Vehicles - What Can Be Done?

    Science.gov (United States)

    Hazziq Zufar, Khairul; Jazlan, Ahmad

    2017-11-01

    Nowadays, the media have reported an increasing number of cases where children are accidentally being trapped in vehicles while they parents and guardians are away attending to other matters. In this paper we discuss the feasibility of applying Mechatronics to improve the safety of children in vehicles with the ultimate goal of developing a means for parents,guardians and authorities to be informed if ever there is a child trapped in a vehicle and in need of urgent assistance. We have also presented some preliminary experiments we have carried out for a safety alert system which is currently being developed in our lab.

  18. Applying Transformative Service Design to Develop Brand Community Service in Women, Children and Infants Retailing

    OpenAIRE

    Shian Wan; Yi-Chang Wang; Yu-Chien Lin

    2016-01-01

    This research discussed the various theories of service design, the importance of service design methodology, and the development of transformative service design framework. In this study, transformative service design is applied while building a new brand community service for women, children and infants retailing business. The goal is to enhance the brand recognition and customer loyalty, effectively increase the brand community engagement by embedding the brand community in social network ...

  19. Sufficiency Grounded as Sufficiently Free: A Reply to Shlomi Segall

    DEFF Research Database (Denmark)

    Nielsen, Lasse

    2016-01-01

    be grounded on (i) any personal value, nor (ii) any impersonal value. Consequently, sufficientarianism is groundless. This article contains a rejoinder to this critique. Its main claim is that the value of autonomy holds strong potential for grounding sufficiency. It argues, firstly, that autonomy carries...... both personal value for its recipient as well as impersonal value, and that both of these values are suitable for grounding sufficiency. It thus follows that we should reject both (i) and (ii). Secondly, although autonomy is presumably the strongest candidate for grounding sufficiency, the article...... provides some counterargument to Segall’s rejection of the other candidates—the impersonal value of virtue; the personal value for the allocator; and the personal value for others. If the arguments are sound, they show that we need not worry about sufficientarianism being groundless....

  20. Dog-Assisted Therapy (DAT Applied to Children with Autism Spectrum Disorder (ASD in School Age

    Directory of Open Access Journals (Sweden)

    María Dolores Jara-Gil

    2017-11-01

    Full Text Available With this study and through an extensive literature review, firstly, it tries to bring the reader to the field of Autism Spectrum Disorder (ASD and the Animal-Assisted Therapy (AAT, which are novel therapeutic alternative very effective and applicable to both children, young people and adults, whether in the academic, social as in the clinical field. Secondly, this work goes after to demonstrate the therapeutic effects that are obtained when we applying a AAT, in this case, a Dog-Assisted Therapy (DAT on children with ASD, and to demonstrate that it can be used as a complement to any type of treatment, be outlined the great and unknown importance in the lives of whom suffer from this disorder, besides to improve the different areas of the ASD and to demonstrate the extensive benefits, contributions and improvements that dogs are capable to produce.

  1. Information geometry and sufficient statistics

    Czech Academy of Sciences Publication Activity Database

    Ay, N.; Jost, J.; Le, Hong-Van; Schwachhöfer, L.

    2015-01-01

    Roč. 162, 1-2 (2015), s. 327-364 ISSN 0178-8051 Institutional support: RVO:67985840 Keywords : Fisher quadratic form * Amari-Chentsov tensor * sufficient statistic Subject RIV: BA - General Mathematics Impact factor: 2.204, year: 2015 http://link.springer.com/article/10.1007/s00440-014-0574-8

  2. [Therapeutic effect of early applying hydrotherapy with Chinese drugs on children hypoxic ischemic encephalopathy].

    Science.gov (United States)

    Ma, Yun-Zhi; Zhai, Hong-Yin; Su, Chun-Ya

    2009-02-01

    To observe the therapeutic effect of hydrotherapy with Chinese drugs (HT-C) in early intervention on children hypoxic ischemic encephalopathy (HIE). HIE children were assigned to the treatment group and the control group, 50 in each, at random depending on the willingness of patients' parents. Both groups received the conventional functional training, according to the "0 -3-year-old early intervention outline", but for the treatment group, HT-C was applied additionally. Indexes for quality of sleep, gross motor function, severity of spasm and intellectual development were observed and compared before and after treatment to assess the therapeutic effects. Therapeutic effect in the treatment group was better than that in the control group in all the indexes observed, showing statistical significance (all P <0.05). Early intervention of HT-C could improve clinical symptom, promote the functional recovery and intellectual development in children HIE, and also could reduce or prevent the sequelae occurrence of the nervous system in them.

  3. Applied behavior analysis: behavior management of children with autism spectrum disorders in dental environments.

    Science.gov (United States)

    Hernandez, Purnima; Ikkanda, Zachary

    2011-03-01

    There are a limited number of studies addressing behavior management techniques and procedural modifications that dentists can use to treat people with an autism spectrum disorder (ASD). The authors conducted a search of the dental and behavioral analytic literature to identify management techniques that address problem behaviors exhibited by children with ASDs in dental and other health-related environments. Applied behavior analysis (ABA) is a science in which procedures are based on the principles of behavior through systematic experimentation. Clinicians have used ABA procedures successfully to modify socially significant behaviors of people with ASD. Basic behavior management techniques currently used in dentistry may not encourage people with cognitive and behavioral disabilities, such as ASD, to tolerate simple in-office dental procedures consistently. Instead, dental care providers often are required to use advanced behavior management techniques to complete simple in-office procedures such as prophylaxis, sealant placement and obtaining radiographs. ABA procedures can be integrated in the dental environment to manage problem behaviors often exhibited by children with an ASD. The authors found no evidence-based procedural modifications that address the behavioral characteristics and problematic behaviors of children with an ASD in a dental environment. Further research in this area should be conducted. Knowledge and in-depth understanding of behavioral principles is essential when a dentist is concerned with modifying behaviors. Using ABA procedures can help dentists manage problem behaviors effectively and systematically when performing routine dental treatment. Being knowledgeable about each patient's behavioral characteristics and the parents' level of involvement is important in the successful integration of the procedures and reduction of in-office time.

  4. Energy Self-Sufficient Island

    International Nuclear Information System (INIS)

    Bratic, S.; Krajacic, G.; Duic, N.; Cotar, A.; Jardas, D.

    2011-01-01

    In order to analyze energy self-sufficient island, example of a smaller island, connected to the power system of a bigger island with an undersea cable, was taken. Mounting substation 10/0,4 is situated on the island and for the moment it provides enough electricity using the medium voltage line. It is assumed that the island is situated on the north part of the Adriatic Sea. The most important problem that occurs on the island is the population drop that occurs for a significant number of years, therefore, life standard needs to be improved, and economic development needs to be encouraged immediately. Local authorities to stimulate sustainable development on the island through different projects, to breath in a new life to the island, open new jobs and attract new people to come live there. Because of the planned development and increase of the population, energy projects, planned as a support to sustainable development, and later achievement of the energy self-sufficiency, is described in this paper. Therefore, Rewisland methodology appliance is described taking into the account three possible scenarios of energy development. Each scenario is calculated until year 2030. Also, what is taken into the account is 100% usage of renewable sources of energy in 2030. Scenario PTV, PP, EE - This scenario includes installation of solar photovoltaic modules and solar thermal collectors on the buildings roofs, as well as well as implementation of energy efficiency on the island (replacement of the street light bulbs with LED lightning, replacement of the old windows and doors on the houses, as well as the installation of the thermal insulation). Scenario PV island - This scenario, similarly to the previous one, includes installation of solar photovoltaic modules and solar thermal collectors an the residential buildings, as well as the 2 MW photovoltaic power plant and ''Green Hotel'', a building that satisfies all of its energy needs completely from renewable energy sources

  5. Energy Strategic Planning & Sufficiency Project

    Energy Technology Data Exchange (ETDEWEB)

    Retziaff, Greg

    2005-03-30

    This report provides information regarding options available, their advantages and disadvantages, and the costs for pursuing activities to advance Smith River Rancheria toward an energy program that reduces their energy costs, allows greater self-sufficiency and stimulates economic development and employment opportunities within and around the reservation. The primary subjects addressed in this report are as follows: (1) Baseline Assessment of Current Energy Costs--An evaluation of the historical energy costs for Smith River was conducted to identify the costs for each component of their energy supply to better assess changes that can be considered for energy cost reductions. (2) Research Viable Energy Options--This includes a general description of many power generation technologies and identification of their relative costs, advantages and disadvantages. Through this research the generation technology options that are most suited for this application were identified. (3) Project Development Considerations--The basic steps and associated challenges of developing a generation project utilizing the selected technologies are identified and discussed. This included items like selling to third parties, wheeling, electrical interconnections, fuel supply, permitting, standby power, and transmission studies. (4) Energy Conservation--The myriad of federal, state and utility programs offered for low-income weatherization and utility bill payment assistance are identified, their qualification requirements discussed, and the subsequent benefits outlined. (5) Establishing an Energy Organization--The report includes a high level discussion of formation of a utility to serve the Tribal membership. The value or advantages of such action is discussed along with some of the challenges. (6) Training--Training opportunities available to the Tribal membership are identified.

  6. Sufficiency of the Nuclear Fuel

    International Nuclear Information System (INIS)

    Pevec, D.; Knapp, V.; Matijevic, M.

    2008-01-01

    Estimation of the nuclear fuel sufficiency is required for rational decision making on long-term energy strategy. In the past an argument often invoked against nuclear energy was that uranium resources are inadequate. At present, when climate change associated with CO 2 emission is a major concern, one novel strong argument for nuclear energy is that it can produce large amounts of energy without the CO 2 emission. Increased interest in nuclear energy is evident, and a new look into uranium resources is relevant. We examined three different scenarios of nuclear capacity growth. The low growth of 0.4 percent per year in nuclear capacity is assumed for the first scenario. The moderate growth of 1.5 percent per year in nuclear capacity preserving the present share in total energy production is assumed for the second scenario. We estimated draining out time periods for conventional resources of uranium using once through fuel cycle for the both scenarios. For the first and the second scenario we obtained the draining out time periods for conventional uranium resources of 154 years and 96 years, respectively. These results are, as expected, in agreement with usual evaluations. However, if nuclear energy is to make a major impact on CO 2 emission it should contribute much more in the total energy production than at present level of 6 percent. We therefore defined the third scenario which would increase nuclear share in the total energy production from 6 percent in year 2020 to 30 percent by year 2060 while the total world energy production would grow by 1.5 percent per year. We also looked into the uranium requirement for this scenario, determining the time window for introduction of uranium or thorium reprocessing and for better use of uranium than what is the case in the once through fuel cycle. The once through cycle would be in this scenario sustainable up to about year 2060 providing most of the expected but undiscovered conventional uranium resources were turned

  7. Applying Cognitive Behavioural Methods to Retrain Children's Attributions for Success and Failure in Learning

    Science.gov (United States)

    Toland, John; Boyle, Christopher

    2008-01-01

    This study involves the use of methods derived from cognitive behavioral therapy (CBT) to change the attributions for success and failure of school children with regard to learning. Children with learning difficulties and/or motivational and self-esteem difficulties (n = 29) were identified by their schools. The children then took part in twelve…

  8. Applying Evolutionary Psychology to a Serious Game about Children's Interpersonal Conflict

    Directory of Open Access Journals (Sweden)

    Gordon P. D. Ingram

    2012-12-01

    Full Text Available This article describes the use of evolutionary psychology to inform the design of a serious computer game aimed at improving 9–12-year-old children's conflict resolution skills. The design of the game will include dynamic narrative generation and emotional tagging, and there is a strong evolutionary rationale for the effect of both of these on conflict resolution. Gender differences will also be taken into consideration in designing the game. In interview research in schools in three countries (Greece, Portugal, and the UK aimed at formalizing the game requirements, we found that gender differences varied in the extent to which they applied cross-culturally. Across the three countries, girls were less likely to talk about responding to conflict with physical aggression, talked more about feeling sad about conflict and about conflicts over friendship alliances, and talked less about conflicts in the context of sports or games. Predicted gender differences in anger and reconciliation were not found. Results are interpreted in terms of differing underlying models of friendship that are motivated by parental investment theory. This research will inform the design of the themes that we use in game scenarios for both girls and boys.

  9. Applying evolutionary psychology to a serious game about children's interpersonal conflict.

    Science.gov (United States)

    Ingram, Gordon P D; Campos, Joana; Hondrou, Charline; Vasalou, Asimina; Martinho, Carlos; Joinson, Adam

    2012-12-20

    This article describes the use of evolutionary psychology to inform the design of a serious computer game aimed at improving 9-12-year-old children's conflict resolution skills. The design of the game will include dynamic narrative generation and emotional tagging, and there is a strong evolutionary rationale for the effect of both of these on conflict resolution. Gender differences will also be taken into consideration in designing the game. In interview research in schools in three countries (Greece, Portugal, and the UK) aimed at formalizing the game requirements, we found that gender differences varied in the extent to which they applied cross-culturally. Across the three countries, girls were less likely to talk about responding to conflict with physical aggression, talked more about feeling sad about conflict and about conflicts over friendship alliances, and talked less about conflicts in the context of sports or games. Predicted gender differences in anger and reconciliation were not found. Results are interpreted in terms of differing underlying models of friendship that are motivated by parental investment theory. This research will inform the design of the themes that we use in game scenarios for both girls and boys.

  10. Parents' Experiences of Applied Behaviour Analysis (ABA)-Based Interventions for Children Diagnosed with Autistic Spectrum Disorder

    Science.gov (United States)

    McPhilemy, Catherine; Dillenburger, Karola

    2013-01-01

    Applied behaviour analysis (ABA)-based programmes are endorsed as the gold standard for treatment of children with autistic spectrum disorder (ASD) in most of North America. This is not the case in most of Europe, where instead a non-specified "eclectic" approach is adopted. We explored the social validity of ABA-based interventions with…

  11. Procedures and Compliance of a Video Modeling Applied Behavior Analysis Intervention for Brazilian Parents of Children with Autism Spectrum Disorders

    Science.gov (United States)

    Bagaiolo, Leila F.; Mari, Jair de J.; Bordini, Daniela; Ribeiro, Tatiane C.; Martone, Maria Carolina C.; Caetano, Sheila C.; Brunoni, Decio; Brentani, Helena; Paula, Cristiane S.

    2017-01-01

    Video modeling using applied behavior analysis techniques is one of the most promising and cost-effective ways to improve social skills for parents with autism spectrum disorder children. The main objectives were: (1) To elaborate/describe videos to improve eye contact and joint attention, and to decrease disruptive behaviors of autism spectrum…

  12. Applying a Socioecological Model to Understand Preschool Children's Sedentary Behaviors from the Viewpoints of Parents and Preschool Personnel

    Science.gov (United States)

    Määttä, Suvi; Ray, Carola; Roos, Gun; Roos, Eva

    2016-01-01

    This study explored parents' and preschool personnel's opinions on factors influencing 3-5-year-old children's sedentary behaviors by applying the socioecological model. Four focus group interviews with preschool personnel (N = 14) and six interviews with parents (N = 17) were conducted in autumn 2014. Two researchers independently analyzed the…

  13. Applying Space Technology to Enhance Control of an Artificial Arm for Children and Adults With Amputations

    Science.gov (United States)

    Atkins, Diane J.

    1998-01-01

    The first single function myoelectric prosthetic hand was introduced in the 1960's. This hand was controlled by the electric fields generated by muscle contractions in the residual limb of the amputee user. Electrodes and amplifiers, embedded in the prosthetic socket, measured these electric fields across the skin, which increase in amplitude as the individual contracts their muscle. When the myoelectric signal reached a certain threshold amplitude, the control unit activated a motor which opened or closed a hand-like prosthetic terminal device with a pincher grip. Late in the 1990's, little has changed. Most current myoelectric prostheses still operate in this same, single-function way. To better understand the limitations of the current single-function myoelectric hand and the needs of those who use them, The Institute for Rehabilitation and Research (TIRR), sponsored by the National Institutes of Health (NUH), surveyed approximately 2,500 individuals with upper limb loss [1]. When asked to identify specific features of their current myoelectric prostheses that needed improvement, the survey respondents overwhelmingly identified the lack of wrist and finger movement, as well as poor control capability. However, simply building a mechanism with individual finger and wrist motion is not enough. In the 1960's and 1970's, engineers built a number of more dexterous prosthetic hands. Unfortunately, these were rejected during clinical trials due to a difficult and distracting control interface. The goal of this project, "Applying Space Technology to Enhance Control of an Artificial Arm for Children and Adults with Amputations," was to lay the foundation for a multi-function, intuitive myoelectric control system which requires no conscious thought to move the hand. We built an extensive myoelectric signal database for six motions from ten amputee volunteers, We also tested a control system based on new artificial intelligence techniques on the data from two of these

  14. Development and Evaluation of Self-Applied Plaque Indices for Children.

    Science.gov (United States)

    Hunter, Harold G.; And Others

    This paper reports on one of the main goals of preventive dentistry, that is, encouraging children to remove plaque at least once a day. Two self-scoring systems were combined with two disclosants for a total of four experimental systems administered to 128 children. In the count method, the child counts the number of stained teeth; in the rating…

  15. Applying an Observational Lens to Identify Parental Behaviours Associated with Children's Homework Motivation

    Science.gov (United States)

    Pino-Pasternak, Deborah

    2014-01-01

    Background: Extant research has traditionally associated children's achievement motivation with socio-emotional parental behaviours such as demonstrations of affect, responsiveness, and the degree of parental control. Aims: This study explored the extent to which parental socio-emotional and instructional behaviours (including the contingency…

  16. Applying MacKinnon's 4Ps to Foster Creative Thinking and Creative Behaviours in Kindergarten Children

    Science.gov (United States)

    Riga, Vassiliki; Chronopoulou, Elena

    2014-01-01

    The purpose of this study was to identify certain strategies and conditions that should be used by teachers in kindergarten so as to foster creative thinking and creative behaviours to children. We used a quasi-experimental research design for 6 months in a public kindergarten in a suburban area of Greece, and we developed a creative music and…

  17. Applying the ADAPT Psychosocial Model to War-Affected Children and Adolescents

    Directory of Open Access Journals (Sweden)

    Sophie Yohani

    2015-09-01

    Full Text Available Multiple individual, social, and environmental factors have long been recognized as influencing a child’s response to traumatic experiences. However, there remain few socio-ecological frameworks to guide researchers and practitioners working with war-affected children. This article examines Silove’s psychosocial model of adaptation and development after trauma and persecution (ADAPT model in relation to war-affected children. The utility of the model is explored by examining whether the systems of safety, attachment, identity, justice, and existential meaning described in the ADAPT model are represented in a narrative review of research from the last 20 years on the experiences of war-affected children and adolescents. Results suggest that research with war-affected children has covered all five psychosocial pillars in the model, but with overemphasis on the safety, followed by the attachment, domains. This review highlights that need for research and psychosocial interventions that focus on adaptation of war-affected children’s identity development, sense of justice, and meaning systems.

  18. Teaching Young Children about the Civil Rights Movement: Applying Effective & Developmentally Appropriate Strategies

    Science.gov (United States)

    Foster, Janet E.; Root, Tonja L.; Lee, Seungyoun

    2015-01-01

    Considering the importance of the Civil Rights Movement, children need to be introduced to the related concepts early in their school experiences, and teachers need to consider students' developmental needs and curriculum standards in order to provide appropriate content and methods of instruction. The purpose of this article is to introduce a…

  19. Federal Privacy Laws That Apply to Children and Education. Safeguarding Data

    Science.gov (United States)

    Data Quality Campaign, 2014

    2014-01-01

    This table identifies and briefly describes the following federal policies that safeguard and protect the confidentiality of personal information: (1) Family Educational Rights and Privacy Act (FERPA); (2) Protection of Pupil Rights Amendment (PPRA); (3) Health Insurance Portability and Accountability Act (HIPAA); (4) Children's Online Privacy…

  20. The acquired preparedness risk model applied to smoking in 5th grade children.

    Science.gov (United States)

    Combs, Jessica L; Spillane, Nichea S; Caudill, Leann; Stark, Brittany; Smith, Gregory T

    2012-03-01

    The very early onset of smoking predicts numerous health problems. The authors conducted the first test of one risk model for elementary school age smoking, known as the acquired preparedness (AP) model of risk, in a cross-sectional sample of 309 5th grade children. The model posits that (a) impulsivity-related personality traits contribute to risk for a variety of risky, maladaptive behaviors; (b) smoking expectancies confer risk only for smoking; and (c) the personality traits contribute to the formation of high risk expectancies for reinforcement from smoking, which in turn increases the likelihood of early onset smoking. The model was supported: the high-risk personality traits distinguished children engaging in any risky, maladaptive behavior from other children, and the smoking expectancies differentiated smokers from all other children. The relationship between personality tendencies to act rashly when experiencing intense positive or negative emotions and smoker status was partially mediated by expectancies for reinforcement from smoking. This model should be investigated longitudinally. Copyright © 2011. Published by Elsevier Ltd.

  1. Procedures and compliance of a video modeling applied behavior analysis intervention for Brazilian parents of children with autism spectrum disorders.

    Science.gov (United States)

    Bagaiolo, Leila F; Mari, Jair de J; Bordini, Daniela; Ribeiro, Tatiane C; Martone, Maria Carolina C; Caetano, Sheila C; Brunoni, Decio; Brentani, Helena; Paula, Cristiane S

    2017-07-01

    Video modeling using applied behavior analysis techniques is one of the most promising and cost-effective ways to improve social skills for parents with autism spectrum disorder children. The main objectives were: (1) To elaborate/describe videos to improve eye contact and joint attention, and to decrease disruptive behaviors of autism spectrum disorder children, (2) to describe a low-cost parental training intervention, and (3) to assess participant's compliance. This is a descriptive study of a clinical trial for autism spectrum disorder children. The parental training intervention was delivered over 22 weeks based on video modeling. Parents with at least 8 years of schooling with an autism spectrum disorder child between 3 and 6 years old with an IQ lower than 70 were invited to participate. A total of 67 parents fulfilled the study criteria and were randomized into two groups: 34 as the intervention and 33 as controls. In all, 14 videos were recorded covering management of disruptive behaviors, prompting hierarchy, preference assessment, and acquisition of better eye contact and joint attention. Compliance varied as follows: good 32.4%, reasonable 38.2%, low 5.9%, and 23.5% with no compliance. Video modeling parental training seems a promising, feasible, and low-cost way to deliver care for children with autism spectrum disorder, particularly for populations with scarce treatment resources.

  2. The effects of music therapy incorporated with applied behavior analysis verbal behavior approach for children with autism spectrum disorders.

    Science.gov (United States)

    Lim, Hayoung A; Draper, Ellary

    2011-01-01

    This study compared a common form of Applied Behavior Analysis Verbal Behavior (ABA VB) approach and music incorporated with ABA VB method as part of developmental speech-language training in the speech production of children with Autism Spectrum Disorders (ASD). This study explored how the perception of musical patterns incorporated in ABA VB operants impacted the production of speech in children with ASD. Participants were 22 children with ASD, age range 3 to 5 years, who were verbal or pre verbal with presence of immediate echolalia. They were randomly assigned a set of target words for each of the 3 training conditions: (a) music incorporated ABA VB, (b) speech (ABA VB) and (c) no-training. Results showed both music and speech trainings were effective for production of the four ABA verbal operants; however, the difference between music and speech training was not statistically different. Results also indicated that music incorporated ABA VB training was most effective in echoic production, and speech training was most effective in tact production. Music can be incorporated into the ABA VB training method, and musical stimuli can be used as successfully as ABA VB speech training to enhance the functional verbal production in children with ASD.

  3. Applying cost analyses to drive policy that protects children. Mercury as a case study

    Energy Technology Data Exchange (ETDEWEB)

    Leonardo Trasande; Clyde Schechter; Karla A. Haynes; Philip J. Landrigan [Mount Sinai School of Medicine, New York, NY (United States). Department of Community and Preventive Medicine

    2006-09-15

    Exposure in prenatal life to methylmercury (MeHg) has become the topic of intense debate in the United States after the Environmental Protection Agency (EPA) announced a proposal in 2004 to reverse strict controls on emissions of mercury from coal-fired power plants that had been in effect for the preceding 15 years. This proposal failed to incorporate any consideration of the health impacts on children that would result from increased mercury emissions. We assessed the impact on children's health of industrial mercury emissions and found that between 316,588 and 637,233 babies are born with mercury-related losses of cognitive function ranging from 0.2 to 5.13 points. We calculated that decreased economic productivity resulting from diminished intelligence over a lifetime results in an aggregate economic cost in each annual birth cohort of $8.7 billion annually. $1.3 billion of this cost is attributable to mercury emitted from American coal-fired power plants. Downward shifts in intellectual quotient (IQ) are also associated with 1566 excess cases of mental retardation annually. This number accounts for 3.2% of MR cases in the United States. If the lifetime excess cost of a case of MR is $1,248,648 in 2000 dollars, then the cost of these excess cases of MR is $2.0 billion annually. Preliminary data suggest that more stringent mercury policy options would prevent thousands of cases of MR and billions of dollars over the next 25 years.

  4. Applying a developmental approach to quality of life assessment in children and adolescents with psychological disorders: challenges and guidelines.

    Science.gov (United States)

    Carona, Carlos; Silva, Neuza; Moreira, Helena

    2015-02-01

    Research on the quality of life (QL) of children/adolescents with psychological disorders has flourished over the last few decades. Given the developmental challenges of QL measurements in pediatric populations, the aim of this study was to ascertain the extent to which a developmental approach to QL assessment has been applied to pedopsychiatric QL research. A systematic literature search was conducted in three electronic databases (PubMed, PsycINFO, SocINDEX) from 1994 to May 2014. Quantitative studies were included if they assessed the self- or proxy-reported QL of children/adolescents with a psychological disorder. Data were extracted for study design, participants, QL instruments and informants, and statistical approach to age-related specificities. The systematic review revealed widespread utilization of developmentally appropriate QL instruments but less frequent use of both self and proxy reports and an inconsistent approach to age group specificities. Methodological guidelines are discussed to improve the developmental validity of QL research for children/adolescents with mental disorders.

  5. Psychometric properties of the Child Health Assessment Questionnaire (CHAQ applied to children and adolescents with cerebral palsy

    Directory of Open Access Journals (Sweden)

    Araújo Renata RH

    2008-12-01

    Full Text Available Abstract Background Cerebral palsy (CP patients have motor limitations that can affect functionality and abilities for activities of daily living (ADL. Health related quality of life and health status instruments validated to be applied to these patients do not directly approach the concepts of functionality or ADL. The Child Health Assessment Questionnaire (CHAQ seems to be a good instrument to approach this dimension, but it was never used for CP patients. The purpose of the study was to verify the psychometric properties of CHAQ applied to children and adolescents with CP. Methods Parents or guardians of children and adolescents with CP, aged 5 to 18 years, answered the CHAQ. A healthy group of 314 children and adolescents was recruited during the validation of the CHAQ Brazilian-version. Data quality, reliability and validity were studied. The motor function was evaluated by the Gross Motor Function Measure (GMFM. Results Ninety-six parents/guardians answered the questionnaire. The age of the patients ranged from 5 to 17.9 years (average: 9.3. The rate of missing data was low (disability index with the visual analogue scales was not significant; for the convergent validity CHAQ disability index had a strong correlation with the GMFM (0.77; for the divergent validity there was no correlation between GMFM and the pain and overall evaluation scales; for the criterion validity GMFM as well as CHAQ detected differences in the scores among the clinical type of CP (p disability index score (mean:2.16; SD:0.72 was higher than the healthy group (mean:0.12; SD:0.23(p Conclusion CHAQ reliability and validity were adequate to this population. However, further studies are necessary to verify the influence of the ceiling effect on the responsiveness of the instrument.

  6. DYNAMIC SUFFICIENCY OF THE MAGNETICALLY SUSPENDED TRAIN

    Directory of Open Access Journals (Sweden)

    V. A. Polyakov

    2013-11-01

    Full Text Available Purpose. The basic criterion of the magnetically suspended train's consumer estimation is a quality of its mechanical motion. This motion is realized in unpredictable conditions and, for purposefulness preservation, should adapt to them. Such adaptation is possible only within the limits of system’s dynamic sufficiency. Sufficiency is understood as presence at system of resources, which allow one to realize its demanded motions without violating actual restrictions. Therefore presence of such resources is a necessary condition of preservation of required purposefulness of train's dynamics, and verification of the mentioned sufficiency is the major component of this dynamic research. Methodology. Methods of the set theory are used in work. Desirable and actual approachability spaces of the train are found. The train is considered dynamically sufficient in zones of the specified spaces overlapping. Findings. Within the limits of the accepted treatment of train's dynamic sufficiency, verification of its presence, as well as a stock (or deficiency of preservations can be executed by the search and the subsequent estimation of such overlapping zones. Operatively (directly during motion it can be realized on the train's ODC with use, for example, of computer mathematics system Mathematica. It possesses extensive opportunities of highly efficient and, at the same time, demanding an expense concerning small resources information manipulation. The efficiency of using of created technique is illustrated on an example of vehicle's acceleration research. Calculation is executed with use of the constructed computer model of interaction of an independent traction electromagnetic subsystem of an artifact with its mechanical subsystem. Originality. The technique of verification of the high-speed magnetically suspended train's dynamic sufficiency is developed. The technique is highly efficient, it provides sufficient presentation and demands an expense of the

  7. How to apply SHA 2011 at a subnational level in China's practical situation: take children health expenditure as an example.

    Science.gov (United States)

    Li, Mingyang; Zheng, Ang; Duan, Wenjuan; Mu, Xin; Liu, Chunli; Yang, Yang; Wang, Xin

    2018-06-01

    System of Health Accounts 2011 (SHA 2011) is a new health care accounts system, revised from SHA 1.0 by the Organisation for Economic Co-operation and Development (OECD), the World Health Organization (WHO) and Eurostat. It keeps the former tri-axial relationship and develops three analytical interfaces, in order to fix the existing shortcomings and make it more convenient for analysis and comparison across countries. SHA 2011 was introduced in China in 2014, and little about its application in China has been reported. This study takes children as an example to study how to apply SHA 2011 at the subnational level in the practical situation of China's health system. Multistage random sampling method was applied and 3 532 517 samples from 252 institutions were included in the study. Official yearbooks and account reports helped the estimation of provincial data. The formula to calculate Current Health Expenditure (CHE) was introduced step-by-step. STATA 10.0 was used for statistics. Under the frame of SHA 2011, the CHE for children in Liaoning was calculated as US$ 0.74 billion in 2014; 98.56% of the expenditure was spent in hospital and the allocation to primary health care institutions was insufficient. Infection, maternal and prenatal diseases cost the most in terms of Global Burden of Disease (GBD), and respiratory system diseases took the leading place in terms of International Classification of Disease Tenth Revision (ICD-10). In addition, medical income contributed most to the health financing. The method to apply SHA 2011 at the subnational level is feasible in China. It makes health accounts more adaptable to rapidly developing health systems and makes the financing data more readily available for analytical use. SHA 2011 is a better health expenditure accounts system to reveal the actual burden on residents and deserves further promotion in China as well as around the world.

  8. A retrospective evaluation of traumatic dental injury in children who applied to the dental hospital, Turkey.

    Science.gov (United States)

    Sari, M E; Ozmen, B; Koyuturk, A E; Tokay, U; Kasap, P; Guler, D

    2014-01-01

    The purpose of this study was to analyze traumatic dental injuries in children visiting the dental hospital emergency department in Samsun of Turkey, in the period from 2007 to 2011. Data of age, gender, causes of dental trauma, injured teeth, type of dental injuries, the application period, the dental treatments, and traumatic dental injuries according to the seasons were obtained from the records at dental hospital. Of all 320 patients with traumatic dental injury, 205 were boys and 115 were girls with a boys/girls ratio 1.78:1. Traumatic dental injury was observed more frequently in the 7-12 age groups: 52.5% in girls and 67.8% in boys. Falls are the major cause of traumatic dental injury in the age group 6-12 (51.4%). Sport activities are a common cause of traumatic dental injury in the 7-12 age group (34.2%). Patients visited a dentist within approximately 2 h (57.1%). The upper anterior teeth were subjected to trauma more frequently than the lower anterior teeth. The maxillary central incisors were the most commonly affected teeth, and the mandibular canins were the least affected teeth. In primary teeth, avulsion was the most common type of dental injury (23%); on the other hand, enamel fractures were the most common type of dental injury (30.6%) observed in permanent teeth. In the primary dentition, the most commonly performed treatments were dental examination and prescribing (70%). The most common treatment choices in permanent teeth were restoration and dental examination (49.7 and 15.8%, respectively). The results of the study show that the emergency intervention to traumatized teeth is important for good prognosis of teeth and oral tissues. Therefore, the parents should be informed about dental trauma in schools, and dental hospital physicians should be subjected to postgraduate training.

  9. Self-sufficiency, free trade and safety.

    Science.gov (United States)

    Rautonen, Jukka

    2010-01-01

    The relationship between free trade, self-sufficiency and safety of blood and blood components has been a perennial discussion topic in the blood service community. Traditionally, national self-sufficiency has been perceived as the ultimate goal that would also maximize safety. However, very few countries are, or can be, truly self-sufficient when self-sufficiency is understood correctly to encompass the whole value chain from the blood donor to the finished product. This is most striking when plasma derived medicines are considered. Free trade of blood products, or competition, as such can have a negative or positive effect on blood safety. Further, free trade of equipment and reagents and several plasma medicines is actually necessary to meet the domestic demand for blood and blood derivatives in most countries. Opposing free trade due to dogmatic reasons is not in the best interest of any country and will be especially harmful for the developing world. Competition between blood services in the USA has been present for decades. The more than threefold differences in blood product prices between European blood services indicate that competition is long overdue in Europe, too. This competition should be welcomed but carefully and proactively regulated to avoid putting safe and secure blood supply at risk. Copyright 2009 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.

  10. Denmark. Self-sufficiency and reserves management

    International Nuclear Information System (INIS)

    Erceville, H. d'.

    1997-01-01

    Since 1991, Denmark is a self-sufficient and a net petroleum and natural gas exporting country. Like all neighboring countries of the North sea, this country enjoys many advantages. However, Denmark exports and imports about a third of its hydrocarbons. This policy is a way to control its reserves for the future. (J.S.)

  11. Error Bounds: Necessary and Sufficient Conditions

    Czech Academy of Sciences Publication Activity Database

    Outrata, Jiří; Kruger, A.Y.; Fabian, Marián; Henrion, R.

    2010-01-01

    Roč. 18, č. 2 (2010), s. 121-149 ISSN 1877-0533 R&D Projects: GA AV ČR IAA100750802 Institutional research plan: CEZ:AV0Z10750506; CEZ:AV0Z10190503 Keywords : Error bounds * Calmness * Subdifferential * Slope Subject RIV: BA - General Mathematics Impact factor: 0.333, year: 2010 http://library.utia.cas.cz/separaty/2010/MTR/outrata-error bounds necessary and sufficient conditions.pdf

  12. The Army Ethic-Inchoate but Sufficient

    Science.gov (United States)

    2015-06-12

    are constraints imposed by this thesis. Delimitations include the scope, jus ad bellum, cultural relativism , descriptive ethics , and implementation...politicians. Third, this thesis will not look in depth at cultural relativism and how changes in laws and society’s philosophical and ethical ...THE ARMY ETHIC –INCHOATE BUT SUFFICIENT A thesis presented to the Faculty of the U.S. Army Command and General Staff College

  13. Children with Auditory Neuropathy Spectrum Disorder Fitted with Hearing Aids Applying the American Academy of Audiology Pediatric Amplification Guideline: Current Practice and Outcomes.

    Science.gov (United States)

    Walker, Elizabeth; McCreery, Ryan; Spratford, Meredith; Roush, Patricia

    2016-03-01

    with HAs, compared to the SNHL group. The American Academy of Audiology Pediatric Amplification Guidelines recommend that children with ANSD receive an HA trial if their behavioral thresholds are sufficiently high enough to impede speech perception at conversational levels. For children with ANSD in the mild-to-severe HL range, the current results support this recommendation, as children with ANSD can achieve functional outcomes similar to peers with SNHL. American Academy of Audiology.

  14. Energy self-sufficiency in Northampton, Massachusetts

    Energy Technology Data Exchange (ETDEWEB)

    1979-10-01

    The study is not an engineering analysis but begins the process of exploring the potential for conservation and local renewable-resource development in a specific community, Northampton, Massachusetts, with the social, institutional, and environmental factors in that community taken into account. Section I is an extensive executive summary of the full study, and Section II is a detailed examination of the potential for increased local energy self-sufficiency in Northampton, including current and future demand estimates, the possible role of conservation and renewable resources, and a discussion of the economic and social implications of alternative energy systems. (MOW)

  15. Assessing sufficient capability: A new approach to economic evaluation.

    Science.gov (United States)

    Mitchell, Paul Mark; Roberts, Tracy E; Barton, Pelham M; Coast, Joanna

    2015-08-01

    Amartya Sen's capability approach has been discussed widely in the health economics discipline. Although measures have been developed to assess capability in economic evaluation, there has been much less attention paid to the decision rules that might be applied alongside. Here, new methods, drawing on the multidimensional poverty and health economics literature, are developed for conducting economic evaluation within the capability approach and focusing on an objective of achieving "sufficient capability". This objective more closely reflects the concern with equity that pervades the capability approach and the method has the advantage of retaining the longitudinal aspect of estimating outcome that is associated with quality-adjusted life years (QALYs), whilst also drawing on notions of shortfall associated with assessments of poverty. Economic evaluation from this perspective is illustrated in an osteoarthritis patient group undergoing joint replacement, with capability wellbeing assessed using ICECAP-O. Recommendations for taking the sufficient capability approach forward are provided. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Efficacy of Distraction Methods on Procedural Pain and Anxiety by Applying Distraction Cards and Kaleidoscope in Children

    Directory of Open Access Journals (Sweden)

    Nejla Canbulat, PhD

    2014-03-01

    Conclusion: The distraction cards were the most effective method for pain and anxiety relief of children during phlebotomy. Also the distraction method with kaleidoscope was an effective method for pain and anxiety relief during phlebotomy in children.

  17. Ideal energy self-sufficient bioclimatic house

    Energy Technology Data Exchange (ETDEWEB)

    Talamo, C.

    1990-04-01

    This paper points out some of the interesting architectural features of a conceptual house being designed to be self-sufficient relative to the use of conventional energy sources. Brief notes are given on the following special design characteristics: the house's orientation and form - essentially a V - shaped two storey design with an orientation such as to maximize the surface area exposed to winter insolation; its special low emissivity glazing equipped with nightfall insulating screens; the adoption of maximized insulation, in which case cost benefits were assessed based on amortization over the entire life span of the house; hybrid space heating and ventilation systems involving the integration of pumps and ventilators for air circulation, and the use of a varied mix of active and passive solar heating and cooling systems.

  18. Sufficient conditions for uniqueness of the weak value

    International Nuclear Information System (INIS)

    Dressel, J; Jordan, A N

    2012-01-01

    We review and clarify the sufficient conditions for uniquely defining the generalized weak value as the weak limit of a conditioned average using the contextual values formalism introduced in Dressel, Agarwal and Jordan (2010 Phys. Rev. Lett. http://dx.doi.org/10.1103/PhysRevLett.104.240401). We also respond to criticism of our work by Parrott (arXiv:1105.4188v1) concerning a proposed counter-example to the uniqueness of the definition of the generalized weak value. The counter-example does not satisfy our prescription in the case of an underspecified measurement context. We show that when the contextual values formalism is properly applied to this example, a natural interpretation of the measurement emerges and the unique definition in the weak limit holds. We also prove a theorem regarding the uniqueness of the definition under our sufficient conditions for the general case. Finally, a second proposed counter-example by Parrott (arXiv:1105.4188v6) is shown not to satisfy the sufficiency conditions for the provided theorem. (paper)

  19. A Randomized Clinical Trial Comparison between Pivotal Response Treatment (PRT) and Structured Applied Behavior Analysis (ABA) Intervention for Children with Autism

    Science.gov (United States)

    Mohammadzaheri, Fereshteh; Koegel, Lynn Kern; Rezaee, Mohammad; Rafiee, Seyed Majid

    2014-01-01

    Accumulating studies are documenting specific motivational variables that, when combined into a naturalistic teaching paradigm, can positively influence the effectiveness of interventions for children with autism spectrum disorder (ASD). The purpose of this study was to compare two applied behavior analysis (ABA) intervention procedures, a…

  20. The Comparison of Effectiveness of Applied Behavioral Analysis and Treatment-Education Approach on Stereotyped Behavior, Interactional and Communicational Problems in Autistic Children

    Directory of Open Access Journals (Sweden)

    Hossein Ghamari-Givi

    2012-10-01

    Full Text Available Objective: The aim of this study was to consider the effectiveness of Applied Behavioral Analysis (ABA therapy and Treatment and Education of Autistic and related Communication handicapped children (TEACCH on stereotyped behavior, interactional and communicational problems in the autistic Children. Materials & Methods: Subjects of this experimental study were all of children in Tabriz autism school in second half of year 1388. Sample size was 29 children (21 boys and 8 girls in age range of 6-14 who were selected using random sampling method and were placed in Applied Behavioral Analysis group (8 boys and 2 girls, Treatment- Education group (9 boys and 1 girl, and control group (4 boys and 5 girls. The two scales applied for the study were Modified Checklist for Autism in Toddlers and Gilliam Autism Rating Scale. The data were analyzed using analysis of covariance. Results: The results of the research showed that the means of behavioral problem indicators in both ABA and TEACCH methods were reduced significantly in comparison with control group (P<0.01. Also in comparison of ABA therapy and TEACCH method, decline in the mean scores of communication problems was significant and in favour of ABA therapy (P<0.05. Conclusion: According to the results of study, although both ABA therapy and TEACCH method were effective in reducing symptoms of behavioral problems but because of being more effective, Applied Behavioral Analysis is suggested as a selective therapeutic approach for this research.

  1. Learn and apply: using multi-sensory storytelling to gather knowledge about preferences and abilities of children with profound intellectual and multiple disabilities--three case studies.

    Science.gov (United States)

    Brug, Annet Ten; Van der Putten, Annette A J; Vlaskamp, Carla

    2013-12-01

    Knowledge about the preferences and abilities of children with profound intellectual and multiple disabilities (PIMDs) is crucial for providing appropriate activities. Multi-sensory storytelling (MSST) can be an ideal activity for gathering such knowledge about children with PIMDs. The aim of this study was to analyse whether using MSST did lead to changes in teachers' knowledge about preferences and abilities and whether this knowledge was then applied in practice. Three dyads of children with PIMDs and their teachers read an MSST book 20 times during a 10-week period. A questionnaire designed to identify the teachers' current knowledge was filled in before the 1st and again after the 10th and 20th reading sessions. Also, the teachers were asked for their opinion about their newly gathered knowledge. In all three cases, changes in the teachers' knowledge were observed. However, teachers are insufficiently aware of their new knowledge and do not apply it in practice.

  2. Guess LOD approach: sufficient conditions for robustness.

    Science.gov (United States)

    Williamson, J A; Amos, C I

    1995-01-01

    Analysis of genetic linkage between a disease and a marker locus requires specifying a genetic model describing both the inheritance pattern and the gene frequencies of the marker and trait loci. Misspecification of the genetic model is likely for etiologically complex diseases. In previous work we have shown through analytic studies that misspecifying the genetic model for disease inheritance does not lead to excess false-positive evidence for genetic linkage provided the genetic marker alleles of all pedigree members are known, or can be inferred without bias from the data. Here, under various selection or ascertainment schemes we extend these previous results to situations in which the genetic model for the marker locus may be incorrect. We provide sufficient conditions for the asymptotic unbiased estimation of the recombination fraction under the null hypothesis of no linkage, and also conditions for the limiting distribution of the likelihood ratio test for no linkage to be chi-squared. Through simulation studies we document some situations under which asymptotic bias can result when the genetic model is misspecified. Among those situations under which an excess of false-positive evidence for genetic linkage can be generated, the most common is failure to provide accurate estimates of the marker allele frequencies. We show that in most cases false-positive evidence for genetic linkage is unlikely to result solely from the misspecification of the genetic model for disease or trait inheritance.

  3. Energy self-sufficiency: dream or reality

    Energy Technology Data Exchange (ETDEWEB)

    1982-01-01

    Twenty six papers from a June 1982 joint conference of the National Research Council of Canada and the Petroleum Society of CIM address areas in which Canadian industry could apply theoretical and experimental mechanics to solve major problems. The papers are grouped under six headings: Coal, Drilling/Completion, Frontier, General, Heavy Oil/Oil sands, and Nuclear. A separate abstract was prepared for each of the papers selected for the Energy Data Base (EDB).

  4. Effects of a Gluten-Free Diet on Rate of Achievement in Autistic Children in an Applied Behavioral Analysis Program.

    Science.gov (United States)

    Gemmell, Melissa; Chambliss, Catherine

    This study used both between-subjects and within-subjects analyses to examine the effects of a gluten-free diet on the academic achievement of autistic children. The between-subjects analysis included data from eight autistic children (ages 5 to 7) with four on a gluten-free diet and four serving as controls. The number of attempts needed before…

  5. Can Classroom Play Ease the Transition to a New Culture? Applying Research on Young Children from Puerto Rico

    Science.gov (United States)

    Trawick-Smith, Jeffrey

    2010-01-01

    It is generally accepted in the fields of both education and psychology that play can help young children cope with troubling circumstances in their lives. It would be logical to assume that play activities may be ideal for assisting children whose families have immigrated to the United States in adjusting to the puzzling, and even frightening,…

  6. "Third Spaces" Are Interesting Places: Applying "Third Space Theory" to Nursery-Aged Children's Constructions of Themselves as Readers

    Science.gov (United States)

    Levy, Rachael

    2008-01-01

    Based on Moje et al.'s (2004) conceptions of "third space theory", this article describes how five nursery-aged children created a "third space" between home and school, in order to find continuity between home and school constructions of reading. This article describes how the children used various aspects of their home…

  7. Energy Strategic Planning & Self-Sufficiency Project

    Energy Technology Data Exchange (ETDEWEB)

    Greg Retzlaff

    2005-03-30

    This report provides information regarding options available, their advantages and disadvantages, and the costs for pursuing activities to advance Smith River Rancheria toward an energy program that reduces their energy costs, allows greater self-sufficiency and stimulates economic development and employment opportunities within and around the reservation. The primary subjects addressed in this report are as follow: (1) Baseline Assessment of Current Energy Costs--An evaluation of the historical energy costs for Smith River was conducted to identify the costs for each component of their energy supply to better assess changes that can be considered for energy cost reductions. (2) Research Viable Energy Options--This includes a general description of many power generation technologies and identification of their relative costs, advantages and disadvantages. Through this research the generation technology options that are most suited for this application were identified. (3) Project Development Considerations--The basic steps and associated challenges of developing a generation project utilizing the selected technologies are identified and discussed. This included items like selling to third parties, wheeling, electrical interconnections, fuel supply, permitting, standby power, and transmission studies. (4) Energy Conservation--The myriad of federal, state and utility programs offered for low-income weatherization and utility bill payment assistance are identified, their qualification requirements discussed, and the subsequent benefits outlined. (5) Establishing an Energy Organization--The report includes a high level discussion of formation of a utility to serve the Tribal membership. The value or advantages of such action is discussed along with some of the challenges. (6) Training--Training opportunities available to the Tribal membership are identified.

  8. A comparison of a modified sequential oral sensory approach to an applied behavior-analytic approach in the treatment of food selectivity in children with autism spectrum disorder.

    Science.gov (United States)

    Peterson, Kathryn M; Piazza, Cathleen C; Volkert, Valerie M

    2016-09-01

    Treatments of pediatric feeding disorders based on applied behavior analysis (ABA) have the most empirical support in the research literature (Volkert & Piazza, 2012); however, professionals often recommend, and caregivers often use, treatments that have limited empirical support. In the current investigation, we compared a modified sequential oral sensory approach (M-SOS; Benson, Parke, Gannon, & Muñoz, 2013) to an ABA approach for the treatment of the food selectivity of 6 children with autism. We randomly assigned 3 children to ABA and 3 children to M-SOS and compared the effects of treatment in a multiple baseline design across novel, healthy target foods. We used a multielement design to assess treatment generalization. Consumption of target foods increased for children who received ABA, but not for children who received M-SOS. We subsequently implemented ABA with the children for whom M-SOS was not effective and observed a potential treatment generalization effect during ABA when M-SOS preceded ABA. © 2016 Society for the Experimental Analysis of Behavior.

  9. Parental attitudes to corporal punishment of children and the analysis of possible Reasons for applying corporal punishment in the family

    OpenAIRE

    Jusienė, Roma

    2006-01-01

    Parental use of corporal punishment is one of the most emotionally charged and attention eliciting topic in child rearing theory and practice, and in social and legal debates as well. The aim of this study is to analyse the parental use of corporal punishment (CP) and attitude to it as related to personal experience of corporal punishment in childhood and to children's psychological adjustment. 110 parents (88 mothers and 22 fathers) who have children aged 4 to 16 years old participated in th...

  10. When is there sufficient information from the Site Investigations?

    International Nuclear Information System (INIS)

    Andersson, Johan; Munier, Raymond; Stroem, Anders; Soederbaeck, Bjoern; Almen, Karl-Erik; Olsson, Lars

    2004-04-01

    can be used in the decision whether and how to continue the investigation. Highlight uncertainty evaluation of aspects of the Site Description judged to be critical to the decision of investigation sufficiency ('uncertainty of key aspects') and to help substantiate how these uncertainties should be explored such that they can be used in the decision analysis. In addressing these objectives the report describes some formal decision analyses tools, assessed potential feedback from Safety Assessment and Rock Engineering, explores some key uncertainty in the Site Description and also explores an example where the decision analyses tools are applied. Based on this work it is generally concluded that the question When to stop the site investigation is a decision problem. In simple words the site investigations should stop when the expected net gain of further investigations is zero or negative, where gain is related to the total cost, which includes several factors besides the direct monetary outlay. Furthermore, this decision perspective should be applied not only in determining the sufficiency of the programme, but also when optimising the remaining parts of the ongoing programme. In particular, it needs to be understood that the Site Investigation is only a step towards the ultimate decision of disposing waste and eventually sealing a repository. The cost and value of information obtained in the Site Investigation Phase, needs to be weighted against the costs and value of obtaining information during later stages. All issues need not be resolved during the Site Investigation Phase. Some could be much better handled later, e.g. during the construction and detailed investigation phase. More specifically, it is recommended to: to actively solicit feedback from Safety Assessment and Repository Engineering, keep track of the uncertainty evaluation of the key aspects of the Site Descriptive Models, develop the Underground Characterisation Programme as this is the next step

  11. Self-sufficiency of an autonomous reconfigurable modular robotic organism

    CERN Document Server

    Qadir, Raja Humza

    2015-01-01

    This book describes how the principle of self-sufficiency can be applied to a reconfigurable modular robotic organism. It shows the design considerations for a novel REPLICATOR robotic platform, both hardware and software, featuring the behavioral characteristics of social insect colonies. Following a comprehensive overview of some of the bio-inspired techniques already available, and of the state-of-the-art in re-configurable modular robotic systems, the book presents a novel power management system with fault-tolerant energy sharing, as well as its implementation in the REPLICATOR robotic modules. In addition, the book discusses, for the first time, the concept of “artificial energy homeostasis” in the context of a modular robotic organism, and shows its verification on a custom-designed simulation framework in different dynamic power distribution and fault tolerance scenarios. This book offers an ideal reference guide for both hardware engineers and software developers involved in the design and implem...

  12. The Relationship between Organizational Support Perceptions and Self-Sufficiencies of Logistics Sector Employees

    Directory of Open Access Journals (Sweden)

    Sefer Gumus

    2016-01-01

    Full Text Available This study was performed in order to examine the relationship between organizational support perceptions and self-sufficiency levels of logistics sector employees and to determine whether organizational support perceptions and self-sufficiency levels of employees differ according to some specification. The questionnaire form consisting of perceived organizational support scale in accordance with the purpose, general self-sufficiency scale and personal information form, was applied to 124 employees of 3 separate logistics firms operating in Istanbul. The data obtained from the questionnaire were analyzed using SPSS17.0 statistical software package on computer. In the assessment of data, descriptive characteristics of employees were determined by frequency and percentage statistics and the self-sufficiency and perceived organizational support levels by the mean and standard deviation statistics. The t test, Tukey test and one-way Anova tests were utilized in determining employees' self-sufficiency and perceived organizational support levels differentiation according to descriptive characteristics, and correlation analysis was utilized in determining the relationship between self-sufficiency and perceived organizational support levels of employees. In conclusion, it was determined that there was statistical relationship between organizational support and self-sufficiency levels perceived by logistics sector employees. Accordingly, when employees' perceived organizational support levels increase then self-sufficiency levels also increase, and when perceived organizational support levels decrease then self-sufficiency levels also decrease.

  13. Applied Behavior Analysis

    Science.gov (United States)

    Szapacs, Cindy

    2006-01-01

    Teaching strategies that work for typically developing children often do not work for those diagnosed with an autism spectrum disorder. However, teaching strategies that work for children with autism do work for typically developing children. In this article, the author explains how the principles and concepts of Applied Behavior Analysis can be…

  14. The Methods Applied by Pre-School Teachers to Raise the Curiosity of Children and Their Views

    Science.gov (United States)

    Buyuktaskapu Soydan, Sema; Erbay, Filiz

    2013-01-01

    The purpose of this study is to determine the strategies used by pre-school teachers in order to raise curiosity in children. Based on this aim, sample is composed of 52 pre-school teachers working in kindergartens affiliated to Ministry of National Education. Study data were collected via qualitative research methods. Research data were gathered…

  15. Empowering people. Alleviating poverty through self-sufficiency.

    Science.gov (United States)

    Nahariya, R

    1993-03-01

    Highlights from an interview with Benjamin D. de Leon, who was appointed Presidential Assistant for Social Development in the Philippines in September 1992, are presented. Mr. de Leon's concern for the marginal sectors of society in health, employment, housing, social welfare, and manpower training as well as his goals of poverty alleviation and people empowerment account for this appointment. Duties include formulating a social development agenda; assisting the Social Development Committee of the Cabinet and the National Economic Development Authority (NEDA) in program implementation; and providing weekly information packages about family planning (FP), health, children, women, and the environment. The social development agenda of the Philippine Medium-term Plan (1992-1998) includes employment, income, wages; population, health and nutrition, and family planning; and housing, education, manpower development, social welfare, and community development. The Plan recognizes that poverty is aggravated by rapid population growth, and it strives to ensure that adolescents, military males, high-risk women, and young unmarried couples receive FP information and services from government agencies and nongovernmental organizations. Adequate resources for population and FP as well as recognizing the relationship among population, resources, and the environment are essential to meet the goals of the plan. The present population and FP policy is based on the 1987 Constitution, which spells out responsible parenthood but also rejects abortion as a method of contraception. The official FP program calls for child survival and safe motherhood and accessible, available, and affordable FP services. The Roman Catholic Church opposes the program, since the Church promotes only the rhythm method, but the other religions approve of the program. Some priests and nuns did not object to the promotion of FP. Sufficient financial support from the international community for the Philippine

  16. The Socioeconomic and Demographic Features of Children with Cerebral Palsi Applied to our Centre from Southern Eastern Anatolian Region

    Directory of Open Access Journals (Sweden)

    Sedat Nacitarhan

    2005-01-01

    Full Text Available Cerebral palsy is a general term which is used to describe a group of disorders that define muscle control impairment due to lesion in the developing brain. The aim of the present study was to indicate the common features of the children with cerebral palsy and their families in South Eastern region of Turkey, the most underdeveloped community in our country. In addition, the rate of marriage between the relatives (consanguineous marriage is higher in this region than the other regions.A total of 258 children with a diagnosis of cerebral palsy were enrolled to our study. These children were born in South Eastern Anatolian region and live here throughout their childhood. Their families were also living in this region. The members of the families were interviewed with the questionnaire to obtain information. Statistical analysis of the results was performed with Graphpad Prism Ver 3.00.68.99 percent of the patients in our study were men, and 31.01 percent were women. They were between the ages of 10-375 months, average was 75.43±59.15 months. Rate of people, who was not under any social security guarantee, was 15.5%. 50.3% of mothers were not literate. Families’ income was 8.5% good, 42.6% poor. In families, there was 33.3% rate of relationship between partners (consanguineous marriage. In 15.5% of families, there was another retarded child. 55 percent of mothers were never been under health check in pregnancy period. Retarded child was usually from first delivery (26.3%. 3.1% of our patients had twin pregnancy. Only 59,6% of the whole births were given at the hospital or by the help of a midwife. Children were suckled along 6.4±6.4 months. Only 8,5% of the children were being educated.Finally, we concluded that reducing convertible risk factors caused by the low education level of our region, underdeveloped socioeconomic conditions and some traditions (e.g. consanguineous marriage and delivery in house instead of health organization has

  17. Effectiveness of a first-aid intervention program applied by undergraduate nursing students to preparatory school children.

    Science.gov (United States)

    Wafik, Wagida; Tork, Hanan

    2014-03-01

    Childhood injuries constitute a major public health problem worldwide. First aid is an effective life-preservation tool at work, school, home, and in public locations. In this study, the effectiveness of a first-aid program delivered by undergraduate nursing students to preparatory school children was examined. This quasi-experimental study was carried out on 100 school children in governmental preparatory schools in Egypt. The researchers designed a program for first-aid training, and this was implemented by trained nursing students. The evaluation involved immediate post-test and follow-up assessment after two months. The results showed generally low levels of satisfactory knowledge and inadequate situational practice among the school students before the intervention. Statistically-significant improvements were shown at the post- and follow-up tests. Multivariate regression analysis identified the intervention and the type of school as the independent predictors of the change in students' knowledge score, while the intervention and the knowledge score were the predictors of the practice score. The study concluded that a first-aid training program delivered by nursing students to preparatory school children is effective in improving their knowledge and practice. © 2013 Wiley Publishing Asia Pty Ltd.

  18. The pro children intervention: applying the intervention mapping protocol to develop a school-based fruit and vegetable promotion programme.

    Science.gov (United States)

    Pérez-Rodrigo, Carmen; Wind, Marianne; Hildonen, Christina; Bjelland, Mona; Aranceta, Javier; Klepp, Knut-Inge; Brug, Johannes

    2005-01-01

    The importance of careful theory-based intervention planning is recognized for fruit and vegetable promotion. This paper describes the application of the Intervention Mapping (IM) protocol to develop the Pro Children intervention to promote consumption of fruit and vegetable among 10- to 13-year-old schoolchildren. Based on a needs assessment, promotion of intake of fruit and vegetable was split into performance objectives and related personal, social and environmental determinants. Crossing the performance objectives with related important and changeable determinants resulted in a matrix of learning and change objectives for which appropriate educational strategies were identified. Theoretically similar but culturally relevant interventions were designed, implemented and evaluated in Norway, the Netherlands and Spain during 2 school years. Programme activities included provision of fruits and vegetables in the schools, guided classroom activities, computer-tailored feedback and advice for children, and activities to be completed at home with the family. Additionally, optional intervention components for community reinforcement included incorporation of mass media, school health services or grocery stores. School project committees were supported. The Pro Children intervention was carefully developed based on the IM protocol that resulted in a comprehensive school-based fruit and vegetable promotion programme, but culturally sensible and locally relevant. (c) 2005 S. Karger AG, Basel

  19. Applying a Developmental Framework to the Self-Regulatory Difficulties of Young Children with Prenatal Alcohol Exposure: A Review.

    Science.gov (United States)

    Reid, Natasha; Petrenko, Christie L M

    2018-06-01

    Prenatal alcohol exposure (PAE) can be associated with significant difficulties in self-regulatory abilities. As such, interventions have been developed that focus on improving varying aspects of self-regulation for this population. The application of a multilevel theoretical framework that describes the development of self-regulation during early childhood could further advance the field. First, this framework could assist in elucidating mechanisms in the trajectories of early adjustment problems in this population and, second, informing the development of more precise assessment and interventions for those affected by PAE. The aims of the current review were to provide an overview of the self-regulatory framework proposed by Calkins and colleagues (e.g., Calkins, 2007; Calkins and Fox, 2002); examine the self-regulatory difficulties that are commonly experienced during infancy (i.e., 0 to 2 years) and early childhood (i.e., 3 to 8 years) in children with PAE in the context of the developmental framework; and describe how the framework can inform the development of future assessment and intervention provision for young children with PAE. The application of a developmental framework, such as proposed by Calkins and colleagues, allows for a systematic and theoretically driven approach to assessment and intervention programs for young children with PAE. Copyright © 2018 by the Research Society on Alcoholism.

  20. Comparison of learning preferences of Turkish children who had been applied cochlear implantation in Turkey and Germany according to theory of multiple intelligence.

    Science.gov (United States)

    Sahli, Sanem; Laszig, Roland; Aschendorff, Antje; Kroeger, Stefanie; Wesarg, Thomas; Belgin, Erol

    2011-12-01

    The aim of the study is to determinate the using dominant multiple intelligence types and compare the learning preferences of Turkish cochlear implanted children aged four to ten in Turkey and Germany according to Theory of multiple intelligence. The study has been conducted on a total of 80 children and four groups in Freiburg/Germany and Ankara/Turkey. The applications have been done in University of Freiburg, Cochlear Implant Center in Germany, and University of Hacettepe, ENT Department, Audiology and Speech Pathology Section in Turkey. In this study, the data have been collected by means of General Information Form and Cochlear Implant Information Form applied to parents. To determine the dominant multiple intelligence types of children, the TIMI (Teele Inventory of Multiple Intelligences) which was developed by Sue Teele have been used. The study results exposed that there was not a statistically significant difference on dominant intelligence areas and averages of scores of multiple intelligence types in control groups (p>0.05). Although, the dominant intelligence areas were different (except for first dominant intelligence) in cochlear implanted children in Turkey and Germany, there was not a statistically significant difference on averages of scores of dominant multiple intelligence types. Every hearing impaired child who started training, should be evaluated in terms of multiple intelligence areas and identified strengths and weaknesses. Multiple intelligence activities should be used in their educational programs. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  1. [The concept of nutritional self-sufficiency and the demographic equilibrium of Rwanda].

    Science.gov (United States)

    Habimana Nyirasafari, G

    1987-12-01

    Achieving food self-sufficiency is the basic strategy of Rwanda's 4th 5-year plan covering 1987-91. The population growth rate has increased from 3% in 1970 to 3.7% in 1983, with the population doubling between 1964 and 1985. Food production grew by about 4%/year between 1966-83, creating a slight increase in per capita food availability, but the 2171 calories available per capita is dangerously close to the theoretical minimum requirement of 2100 per day. The theoretical protein requirement is almost covered, but there is a serious shortage of oils. The increase in production since 1966 has been due almost exclusively to the extension of cultivated land. But the land supply is limited, and future production increases will need to be based on increased yields per unit cultivated. The National Office of Population has developed a simulation model that analyzes the parallel evolution of population and production so as to identify demographic and development policies that will assure food self-sufficiency and an improvement in living conditions. The population subsystem subjects the population divided by age and sex to the effects of fertility, migration, and mortality. Births are the result of 36 different fertility rates applied to the population of women aged 14-49 years. The agricultural subsystem is tied to the population subsystem by comparison of the volume of population to that of production, by estimation of the proportion of the population living exclusively by subsistence agriculture, by calculation of the potential emigration resulting from overpopulation of the countryside, and by estimation of the links between nutritional level, mortality, and duration of breastfeeding. 5 annexes contain subsystems showing effects of demographic growth on education, employment, and health. The model has various limitations including those of the reliability of its data, but it is sufficiently precise for its main function of clarifying the choices facing policymakers. 6

  2. Using Technology to Expand and Enhance Applied Behavioral Analysis Programs for Children with Autism in Military Families

    Science.gov (United States)

    2015-07-01

    University of Nebraska Center for Autism Spectrum Disorders 985450 Nebraska Medical Center Omaha, NE 68198-5450 9. SPONSORING / MONITORING AGENCY...ABSTRACT Autism spectrum disorders (ASDs) are disorders that affect as many 1 in 88 children. Without intensive treatment, the long- term outcomes...29 Appendix………..………………………………………………………………………. 30 4 Introduction Autism spectrum disorders (ASDs) are disorders of the brain that

  3. Treatment Integrity of School-Based Interventions with Children in the "Journal of Applied Behavior Analysis" 1991-2005

    Science.gov (United States)

    McIntyre, Laura Lee; Gresham, Frank M.; DiGennaro, Florence D.; Reed, Derek D.

    2007-01-01

    We reviewed all school-based experimental studies with individuals 0 to 18 years published in the "Journal of Applied Behavior Analysis" (JABA) between 1991 and 2005. A total of 142 articles (152 studies) that met review criteria were included. Nearly all (95%) of these experiments provided an operational definition of the independent variable,…

  4. Validation of Inter-Subject Training for Hidden Markov Models Applied to Gait Phase Detection in Children with Cerebral Palsy

    Directory of Open Access Journals (Sweden)

    Juri Taborri

    2015-09-01

    Full Text Available Gait-phase recognition is a necessary functionality to drive robotic rehabilitation devices for lower limbs. Hidden Markov Models (HMMs represent a viable solution, but they need subject-specific training, making data processing very time-consuming. Here, we validated an inter-subject procedure to avoid the intra-subject one in two, four and six gait-phase models in pediatric subjects. The inter-subject procedure consists in the identification of a standardized parameter set to adapt the model to measurements. We tested the inter-subject procedure both on scalar and distributed classifiers. Ten healthy children and ten hemiplegic children, each equipped with two Inertial Measurement Units placed on shank and foot, were recruited. The sagittal component of angular velocity was recorded by gyroscopes while subjects performed four walking trials on a treadmill. The goodness of classifiers was evaluated with the Receiver Operating Characteristic. The results provided a goodness from good to optimum for all examined classifiers (0 < G < 0.6, with the best performance for the distributed classifier in two-phase recognition (G = 0.02. Differences were found among gait partitioning models, while no differences were found between training procedures with the exception of the shank classifier. Our results raise the possibility of avoiding subject-specific training in HMM for gait-phase recognition and its implementation to control exoskeletons for the pediatric population.

  5. When is there sufficient information from the Site Investigations?

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden); Munier, Raymond; Stroem, Anders; Soederbaeck, Bjoern [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Almen, Karl-Erik [KEA Geo-konsult (Sweden); Olsson, Lars [Geostatistik AB, Tumba (Sweden)

    2004-04-01

    can be used in the decision whether and how to continue the investigation. Highlight uncertainty evaluation of aspects of the Site Description judged to be critical to the decision of investigation sufficiency ('uncertainty of key aspects') and to help substantiate how these uncertainties should be explored such that they can be used in the decision analysis. In addressing these objectives the report describes some formal decision analyses tools, assessed potential feedback from Safety Assessment and Rock Engineering, explores some key uncertainty in the Site Description and also explores an example where the decision analyses tools are applied. Based on this work it is generally concluded that the question When to stop the site investigation is a decision problem. In simple words the site investigations should stop when the expected net gain of further investigations is zero or negative, where gain is related to the total cost, which includes several factors besides the direct monetary outlay. Furthermore, this decision perspective should be applied not only in determining the sufficiency of the programme, but also when optimising the remaining parts of the ongoing programme. In particular, it needs to be understood that the Site Investigation is only a step towards the ultimate decision of disposing waste and eventually sealing a repository. The cost and value of information obtained in the Site Investigation Phase, needs to be weighted against the costs and value of obtaining information during later stages. All issues need not be resolved during the Site Investigation Phase. Some could be much better handled later, e.g. during the construction and detailed investigation phase. More specifically, it is recommended to: to actively solicit feedback from Safety Assessment and Repository Engineering, keep track of the uncertainty evaluation of the key aspects of the Site Descriptive Models, develop the Underground Characterisation Programme as this is the

  6. Using Technology to Expand and Enhance Applied Behavior Analysis Programs for Children with Autism in Military Families

    Science.gov (United States)

    2016-07-01

    Nebraska Medical Center in Omaha). These trained parents will then be able to implement effective behavior management and teaching strategies with... parents . Interventions based on applied behavior analysis are well documented, but unfortunately these services are often not available to military...availability of this effective treatment. The fifth year of the award involved the continued recruitment of families with a child with an ASD to

  7. Powerful Statistical Inference for Nested Data Using Sufficient Summary Statistics

    Science.gov (United States)

    Dowding, Irene; Haufe, Stefan

    2018-01-01

    Hierarchically-organized data arise naturally in many psychology and neuroscience studies. As the standard assumption of independent and identically distributed samples does not hold for such data, two important problems are to accurately estimate group-level effect sizes, and to obtain powerful statistical tests against group-level null hypotheses. A common approach is to summarize subject-level data by a single quantity per subject, which is often the mean or the difference between class means, and treat these as samples in a group-level t-test. This “naive” approach is, however, suboptimal in terms of statistical power, as it ignores information about the intra-subject variance. To address this issue, we review several approaches to deal with nested data, with a focus on methods that are easy to implement. With what we call the sufficient-summary-statistic approach, we highlight a computationally efficient technique that can improve statistical power by taking into account within-subject variances, and we provide step-by-step instructions on how to apply this approach to a number of frequently-used measures of effect size. The properties of the reviewed approaches and the potential benefits over a group-level t-test are quantitatively assessed on simulated data and demonstrated on EEG data from a simulated-driving experiment. PMID:29615885

  8. Micronutrients in the life cycle: Requirements and sufficient supply

    Directory of Open Access Journals (Sweden)

    K. Biesalski Hans

    2018-06-01

    Full Text Available Macronutrients (fat, protein, carbohydrates deliver energy and important material to ensure the entire body composition. Micronutrients are needed to keep this process of continuous construction and re-construction running. Consequently, the requirement for micronutrients will differ depending on the individual need which is related to the different metabolic conditions within the life cycle. Within the first 1000 days of life, from conception to the end of the second year of life the requirement for micronutrients is high and if the supply is inadequate that might have consequences for physical and at least cognitive development. In particular, iron, iodine, vitamin D and folate are micronutrients which might become critical during that period. Due to the fact that clinical symptoms of deficiencies develop late, but inadequate supply of one or more micronutrients may have consequences for health the term hidden hunger has been introduced to describe that situation. In particular the time period of pregnancy and early childhood is critical and hidden hunger is a worldwide problem, affecting >2 billion people, primarily females and children. The importance of different requirements during the life cycle is usually not considered. In addition, we do not really know what the individual requirement is. The estimation of the requirement is based on studies calculating the supply of a micronutrient to avoid a deficiency disease within a healthy population and is not based on sound scientific methodology or data. We need to consider that at different moments in the life cycle the supply might become critical in particular in case of a disease or sudden increase of metabolic turnover. In this narrative review we summarize data from studies dealing with different micronutrient requirements in pregnancy, exercise, vegan diet, adolescents and elderly. Knowledge of critical periods and related critical micronutrients might help to avoid hidden hunger and

  9. Sufficient conditions for Lagrange, Mayer, and Bolza optimization problems

    Directory of Open Access Journals (Sweden)

    Boltyanski V.

    2001-01-01

    Full Text Available The Maximum Principle [2,13] is a well known necessary condition for optimality. This condition, generally, is not sufficient. In [3], the author proved that if there exists regular synthesis of trajectories, the Maximum Principle also is a sufficient condition for time-optimality. In this article, we generalize this result for Lagrange, Mayer, and Bolza optimization problems.

  10. Sufficiency does energy consumption become a moral issue?

    Energy Technology Data Exchange (ETDEWEB)

    Muller, Adrian (Socio-economic Inst. and Univ. Research Priority Programme in Ethics, Univ. of Zuerich, Zuerich (Switzerland))

    2009-07-01

    Reducing the externalities from energy use is crucial for sustainability. There are basically four ways to reduce externalities from energy use: increasing technical efficiency ('energy input per unit energy service'), increasing economic efficiency ('internalising external costs'), using 'clean' energy sources with few externalities, or sufficiency ('identifying 'optimal' energy service levels'). A combination of those strategies is most promising for sustainable energy systems. However, the debate on sustainable energy is dominated by efficiency and clean energy strategies, while sufficiency plays a minor role. Efficiency and clean energy face several problems, though. Thus, the current debate should be complemented with a critical discussion of sufficiency. In this paper, I develop a concept of sufficiency, which is adequate for liberal societies. I focus on ethical foundations for sufficiency, as the discussion of such is missing or cursory only in the existing literature. I first show that many examples of sufficiency can be understood as (economic) efficiency, but that the two concepts do not coincide. I then show that sufficiency based on moralization of actions can be understood as implementation of the boundary conditions for social justice that come with notions of liberal societies, in particular the duty not to harm other people. By this, to increase sufficiency becomes a duty beyond individual taste. I further illustrate this in the context of the adverse effects of climate change as externalities from energy use.

  11. Improving the Perception of Self-Sufficiency towards Creative Drama

    Science.gov (United States)

    Pekdogan, Serpil; Korkmaz, Halil Ibrahim

    2016-01-01

    The purpose of this study is to investigate the effects of a Creative Drama Based Perception of Self-sufficiency Skills Training Program on 2nd grade bachelor degree students' (who are attending a preschool teacher training program) perception of self-sufficiency. This is a quasi-experimental study. Totally 50 students were equally divided into…

  12. India's baseline plan for nuclear energy self-sufficiency

    International Nuclear Information System (INIS)

    Bucher, R.G.

    2009-01-01

    United Nations Conference on the Peaceful Uses of Atomic Energy in 1958. The paper described a three stage plan for a sustainable nuclear energy program consistent with India's limited uranium but abundant thorium natural resources. In the first stage, natural uranium would be used to fuel graphite or heavy water moderated reactors. Plutonium extracted from the spent fuel of these thermal reactors would drive fast reactors in the second stage that would contain thorium blankets for breeding uranium-233 (U-233). In the final stage, this U-233 would fuel thorium burning reactors that would breed and fission U-233 in situ. This three stage blueprint still reigns as the core of India's civil nuclear power program. India's progress in the development of nuclear power, however, has been impacted by its isolation from the international nuclear community for its development of nuclear weapons and consequent refusal to sign the Nuclear Nonproliferation Treaty (NPT). Initially, India was engaged in numerous cooperative research programs with foreign countries; for example, under the 'Atoms for Peace' program, India acquired the Cirus reactor, a 40 MWt research reactor from Canada moderated with heavy water from the United States. India was also actively engaged in negotiations for the NPT. But, on May 18, 1974, India conducted a 'peaceful nuclear explosion' at Pokharan using plutonium produced by the Cirus reactor, abruptly ending the era of international collaboration. India then refused to sign the NPT, which it viewed as discriminatory since it would be required to join as a non-nuclear weapons state. As a result of India's actions, the Nuclear Suppliers Group (NSG) was created in 1975 to establish guidelines 'to apply to nuclear transfers for peaceful purposes to help ensure that such transfers would not be diverted to unsafeguarded nuclear fuel cycle or nuclear explosive activities. These nuclear export controls have forced India to be largely self-sufficient in all nuclear

  13. Stability of matrices with sufficiently strong negative-dominant-diagonal submatrices

    NARCIS (Netherlands)

    Nieuwenhuis, H.J.; Schoonbeek, L.

    A well-known sufficient condition for stability of a system of linear first-order differential equations is that the matrix of the homogeneous dynamics has a negative dominant diagonal. However, this condition cannot be applied to systems of second-order differential equations. In this paper we

  14. A Sufficient Condition for an Interval Matrix to have Full Column Rank

    Czech Academy of Sciences Publication Activity Database

    Rohn, Jiří

    2017-01-01

    Roč. 22, č. 2 (2017), s. 59-66 ISSN 1560-7534 Institutional support: RVO:67985807 Keywords : interval matrix * full column rank * sufficient condition * double condition Subject RIV: BA - General Mathematics OBOR OECD: Applied mathematics http://www.ict.nsc.ru/jct/annotation/1779?l=eng

  15. Sufficient Stochastic Maximum Principle in a Regime-Switching Diffusion Model

    Energy Technology Data Exchange (ETDEWEB)

    Donnelly, Catherine, E-mail: C.Donnelly@hw.ac.uk [Heriot-Watt University, Department of Actuarial Mathematics and Statistics (United Kingdom)

    2011-10-15

    We prove a sufficient stochastic maximum principle for the optimal control of a regime-switching diffusion model. We show the connection to dynamic programming and we apply the result to a quadratic loss minimization problem, which can be used to solve a mean-variance portfolio selection problem.

  16. Sufficient Stochastic Maximum Principle in a Regime-Switching Diffusion Model

    International Nuclear Information System (INIS)

    Donnelly, Catherine

    2011-01-01

    We prove a sufficient stochastic maximum principle for the optimal control of a regime-switching diffusion model. We show the connection to dynamic programming and we apply the result to a quadratic loss minimization problem, which can be used to solve a mean-variance portfolio selection problem.

  17. Sufficient Descent Conjugate Gradient Methods for Solving Convex Constrained Nonlinear Monotone Equations

    Directory of Open Access Journals (Sweden)

    San-Yang Liu

    2014-01-01

    Full Text Available Two unified frameworks of some sufficient descent conjugate gradient methods are considered. Combined with the hyperplane projection method of Solodov and Svaiter, they are extended to solve convex constrained nonlinear monotone equations. Their global convergence is proven under some mild conditions. Numerical results illustrate that these methods are efficient and can be applied to solve large-scale nonsmooth equations.

  18. Community Service and University Roles: An Action Research Based on the Philosophy of Sufficiency Economy

    Science.gov (United States)

    Nuangchalerm, Prasart; Chansirisira, Pacharawit

    2012-01-01

    This study employs action research to develop community service through university roles by applying the philosophy of sufficiency economy of His Majesty the King Bhumibol Adulyadej to fulfill villagers' way of life. Participatory learning, seminar, field trip and supervision were employed for strategic plan. Data were collected by participatory…

  19. Enough is as good as a feast - sufficiency as policy

    Energy Technology Data Exchange (ETDEWEB)

    Darby, Sarah [Lower Carbon Futures, Environmental Change Inst., Oxford Univ. Centre for the Environment (United Kingdom)

    2007-07-01

    The concept of sufficiency has a long history, related as it is to the timeless issues of how best to distribute and use resources. Where energy is concerned, absolute reductions in demand are increasingly seen as necessary in response to climate change and energy security concerns. There is an acknowledgement that, collectively if not individually, humans have gone beyond safe limits in their use of fuels. The relatively wealthy and industrialised nations urgently need to move beyond a primary focus on efficiency to the more contentious issues surrounding demand reduction and sufficiency. The paper considers definitions of energy sufficiency, looks at a recent attempt to model future energy use in terms of efficiency and sufficiency, and discusses quantitative and qualitative aspects of sufficiency and how they might become institutionalised. There are many arguments in favour of sufficiency but they often founder in the face of political requirements for market growth and the employment generated by it. Some options for 'sufficiency policy' are selected, including a focus on energy in relation to livelihoods, energy implications of our use of time and making energy use more transparent.

  20. New Sufficient LMI Conditions for Static Output Stabilization

    DEFF Research Database (Denmark)

    Adegas, Fabiano Daher

    2014-01-01

    This paper presents new linear matrix inequality conditions to the static output feedback stabilization problem. Although the conditions are only sufficient, numerical experiments show excellent success rates in finding a stabilizing controller....

  1. Exploring Societal Preferences for Energy Sufficiency Measures in Switzerland

    International Nuclear Information System (INIS)

    Moser, Corinne; Rösch, Andreas; Stauffacher, Michael

    2015-01-01

    Many countries are facing a challenging transition toward more sustainable energy systems, which produce more renewables and consume less energy. The latter goal can only be achieved through a combination of efficiency measures and changes in people’s lifestyles and routine behaviors (i.e., sufficiency). While research has shown that acceptance of technical efficiency is relatively high, there is a lack of research on societal preferences for sufficiency measures. However, this is an important prerequisite for designing successful interventions to change behavior. This paper analyses societal preferences for different energy-related behaviors in Switzerland. We use an online choice-based conjoint analysis (N = 150) to examine preferences for behaviors with high technical potentials for energy demand reduction in the following domains: mobility, heating, and food. Each domain comprises different attributes across three levels of sufficiency. Respondents were confronted with trade-off situations evoked through different fictional lifestyles that comprised different combinations of attribute levels. Through a series of trade-off decisions, participants were asked to choose their preferred lifestyle. The results revealed that a vegetarian diet was considered the most critical issue that respondents were unwilling to trade off, followed by distance to workplace and means of transportation. The highest willingness to trade off was found for adjustments in room temperature, holiday travel behaviors, and living space. Participants’ preferences for the most energy-sufficient lifestyles were rather low. However, the study showed that there were lifestyles with substantive energy-saving potentials that were well accepted among respondents. Our study results suggest that the success of energy-sufficiency interventions might depend strongly on the targeted behavior. We speculate that they may face strong resistance (e.g., vegetarian diet). Thus, it seems promising to

  2. Exploring Societal Preferences for Energy Sufficiency Measures in Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Moser, Corinne, E-mail: corinne.moser@zhaw.ch [Institute of Sustainable Development, School of Engineering, Zurich University of Applied Sciences, Winterthur (Switzerland); Natural and Social Science Interface, Institute for Environmental Decisions, Department of Environmental Systems Science, ETH Zürich, Zürich (Switzerland); Rösch, Andreas [Natural and Social Science Interface, Institute for Environmental Decisions, Department of Environmental Systems Science, ETH Zürich, Zürich (Switzerland); Stauffacher, Michael [Natural and Social Science Interface, Institute for Environmental Decisions, Department of Environmental Systems Science, ETH Zürich, Zürich (Switzerland); Transdisciplinarity Laboratory, Department of Environmental Systems Science, ETH Zürich, Zürich (Switzerland)

    2015-09-16

    Many countries are facing a challenging transition toward more sustainable energy systems, which produce more renewables and consume less energy. The latter goal can only be achieved through a combination of efficiency measures and changes in people’s lifestyles and routine behaviors (i.e., sufficiency). While research has shown that acceptance of technical efficiency is relatively high, there is a lack of research on societal preferences for sufficiency measures. However, this is an important prerequisite for designing successful interventions to change behavior. This paper analyses societal preferences for different energy-related behaviors in Switzerland. We use an online choice-based conjoint analysis (N = 150) to examine preferences for behaviors with high technical potentials for energy demand reduction in the following domains: mobility, heating, and food. Each domain comprises different attributes across three levels of sufficiency. Respondents were confronted with trade-off situations evoked through different fictional lifestyles that comprised different combinations of attribute levels. Through a series of trade-off decisions, participants were asked to choose their preferred lifestyle. The results revealed that a vegetarian diet was considered the most critical issue that respondents were unwilling to trade off, followed by distance to workplace and means of transportation. The highest willingness to trade off was found for adjustments in room temperature, holiday travel behaviors, and living space. Participants’ preferences for the most energy-sufficient lifestyles were rather low. However, the study showed that there were lifestyles with substantive energy-saving potentials that were well accepted among respondents. Our study results suggest that the success of energy-sufficiency interventions might depend strongly on the targeted behavior. We speculate that they may face strong resistance (e.g., vegetarian diet). Thus, it seems promising to

  3. Role of sufficient statistics in stochastic thermodynamics and its implication to sensory adaptation

    Science.gov (United States)

    Matsumoto, Takumi; Sagawa, Takahiro

    2018-04-01

    A sufficient statistic is a significant concept in statistics, which means a probability variable that has sufficient information required for an inference task. We investigate the roles of sufficient statistics and related quantities in stochastic thermodynamics. Specifically, we prove that for general continuous-time bipartite networks, the existence of a sufficient statistic implies that an informational quantity called the sensory capacity takes the maximum. Since the maximal sensory capacity imposes a constraint that the energetic efficiency cannot exceed one-half, our result implies that the existence of a sufficient statistic is inevitably accompanied by energetic dissipation. We also show that, in a particular parameter region of linear Langevin systems there exists the optimal noise intensity at which the sensory capacity, the information-thermodynamic efficiency, and the total entropy production are optimized at the same time. We apply our general result to a model of sensory adaptation of E. coli and find that the sensory capacity is nearly maximal with experimentally realistic parameters.

  4. The level of energy sufficiency - why all the controversy?

    International Nuclear Information System (INIS)

    Maillard, D.

    2000-01-01

    It as become fashionable in certain circles to attempt to demolish the notion of energy sufficiency, a concept which is now seen as being archaic and unsuitable. To back up their claims, proponents of this standpoint take great pleasure in attacking the corresponding indicator - the rate of energy sufficiency calculated as a ratio of national primary energy production and the total consumption of primary energy (in the same unit and without climatic corrections). Confirming its precarious, conventional and debatable nature seems in their eyes to be the best means of ensuring that both the word, the concept and the measuring method of energy sufficiency are consigned to the dustbin of economic history. After having examined with perhaps a certain irony some of the usual criticisms, I intend to proceed with a re-examination of questions which in my eyes appear to be essential. (author)

  5. Increasing urban water self-sufficiency: New era, new challenges

    DEFF Research Database (Denmark)

    Rygaard, Martin; Binning, Philip John; Albrechtsen, Hans-Jørgen

    2011-01-01

    and 15 in-depth case studies, solutions used to increase water self-sufficiency in urban areas are analyzed. The main drivers for increased self-sufficiency were identified to be direct and indirect lack of water, constrained infrastructure, high quality water demands and commercial and institutional...... pressures. Case studies demonstrate increases in self-sufficiency ratios to as much as 80% with contributions from recycled water, seawater desalination and rainwater collection. The introduction of alternative water resources raises several challenges: energy requirements vary by more than a factor of ten...... amongst the alternative techniques, wastewater reclamation can lead to the appearance of trace contaminants in drinking water, and changes to the drinking water system can meet tough resistance from the public. Public water-supply managers aim to achieve a high level of reliability and stability. We...

  6. Global Sufficient Optimality Conditions for a Special Cubic Minimization Problem

    Directory of Open Access Journals (Sweden)

    Xiaomei Zhang

    2012-01-01

    Full Text Available We present some sufficient global optimality conditions for a special cubic minimization problem with box constraints or binary constraints by extending the global subdifferential approach proposed by V. Jeyakumar et al. (2006. The present conditions generalize the results developed in the work of V. Jeyakumar et al. where a quadratic minimization problem with box constraints or binary constraints was considered. In addition, a special diagonal matrix is constructed, which is used to provide a convenient method for justifying the proposed sufficient conditions. Then, the reformulation of the sufficient conditions follows. It is worth noting that this reformulation is also applicable to the quadratic minimization problem with box or binary constraints considered in the works of V. Jeyakumar et al. (2006 and Y. Wang et al. (2010. Finally some examples demonstrate that our optimality conditions can effectively be used for identifying global minimizers of the certain nonconvex cubic minimization problem.

  7. The Study of Supporting Learning Sufficiency Economy Philosophy of Students Majoring in Early Childhood Education by Backyard Gardening Activity

    Directory of Open Access Journals (Sweden)

    Vannisa Hakoon

    2017-06-01

    Full Text Available This research was aimed to make students majoring in early childhood education learn about the Sufficiency Economy Philosophy by integrating learning process through practicing planting vegetables and herbs, harvesting, processing products and selling the products at the CEECE farm. This case study include 104 students in total, 2 males students and 102 females students majoring in early childhood education in the second semester of academic year 2016, Mahasarakham university. The researcher integrated the learning with subjects in early childhood education field such as Story and literature for young Children, Thai languages and literacy for young children, Independent study in early childhood education and Early childhood education quality assurance. The research instruments were 1 CEECE Farm area for practicing growing vegetables and herbs and 2 Self Reflection from the students. Data collection was conducted through three phases including 1 preparation 2 process and 3 data collection. The researcher analyzed the content by describing and drawing conclusions from students opinions about the learning. This research revealed: 1. Factors affecting success or barriers to learning include students, location, materials, budget, academic advisors and other factors such as climate and workloads of students. 2. Students majoring in early childhood education learn the Sufficiency Economy Philosophy through practicing at the CEECE farm. Students learn Sufficiency Economy Philosophy and knowledge as follows ; 2.1 Moderation: Students learn to use the resources sufficiently. Students realize the value and use resources in order to maximize savings ; location, materials and budget. 2.2 Reasonableness: Students learn to apply the principles of reason and critical thinking to planning decisions and resolving issues arising from the implementation based on information that they have gathered and relies on the concept, “if students are consumers, will they

  8. Quantification is Neither Necessary Nor Sufficient for Measurement

    International Nuclear Information System (INIS)

    Mari, Luca; Maul, Andrew; Torres Irribarra, David; Wilson, Mark

    2013-01-01

    Being an infrastructural, widespread activity, measurement is laden with stereotypes. Some of these concern the role of measurement in the relation between quality and quantity. In particular, it is sometimes argued or assumed that quantification is necessary for measurement; it is also sometimes argued or assumed that quantification is sufficient for or synonymous with measurement. To assess the validity of these positions the concepts of measurement and quantitative evaluation should be independently defined and their relationship analyzed. We contend that the defining characteristic of measurement should be the structure of the process, not a feature of its results. Under this perspective, quantitative evaluation is neither sufficient nor necessary for measurement

  9. Online Learning in Higher Education: Necessary and Sufficient Conditions

    Science.gov (United States)

    Lim, Cher Ping

    2005-01-01

    The spectacular development of information and communication technologies through the Internet has provided opportunities for students to explore the virtual world of information. In this article, the author discusses the necessary and sufficient conditions for successful online learning in educational institutions. The necessary conditions…

  10. Intellectual Freedom and Economic Sufficiency as Educational Entitlements.

    Science.gov (United States)

    Morse, Jane Fowler

    2001-01-01

    Using the theories of John Stuart Mill and Karl Marx, this article supports the educational entitlements of intellectual freedom and economic sufficiency. Explores these issues in reference to their implications for teaching, the teaching profession and its training. Concludes that ideas cannot be controlled by the interests of the dominant class.…

  11. Towards a sufficiency-driven business model : Experiences and opportunities

    NARCIS (Netherlands)

    Bocken, N.M.P.; Short, SW

    2016-01-01

    Business model innovation is an important lever for change to tackle pressing sustainability issues. In this paper, ‘sufficiency’ is proposed as a driver of business model innovation for sustainability. Sufficiency-driven business models seek to moderate overall resource consumption by curbing

  12. Evaluation of a sports program in modifying the symptoms of hyperactivity, inattention and impulsiveness applied to children with Attention Deficit Disorder

    Directory of Open Access Journals (Sweden)

    Paula María Jiménez Palomar

    2013-11-01

    Full Text Available The sport is a phenomenon that contributes to physical health, mental balance and social welfare of the user, and promotes a range of habits and values that impact on the further integration of the individual in their environment. People suffering from Attention Deficit Disorder with Hyperactivity, these abilities are impaired and currently studies are needed to support the hypothesis that physical exercise can be an effective adjunct to this problem. This will do a clinical trial to evaluate the effectiveness of a sports program, which seeks to alter the predominant symptoms of Attention Deficit Disorder with Hypeeractivity. The study will be conducted in the Unit of Child and Adolescent Mental Health in Ciudad Real, and participants will be children between 6 and 12 years with this disorder. It shall consist of the comparison of two groups: one that will only receive the normal care given in the unit and another that will be applied also a sports program. The second will be divided into two groups who will implement the program outdoors or indoors, in order to observe any difference between an environment and another. We will assess impulsivity, inattention and hyperactivity using the Conners scale for teachers, school performance, taking into account the quarterly grades and behavior at home with the Conners scale for parents.

  13. Increased conjugated bilirubin is sufficient to initiate screening for biliary atresia

    DEFF Research Database (Denmark)

    Madsen, Stine Skipper; Kvist, Nina; Thorup, Jørgen

    2015-01-01

    . This percentage value has caused diagnostic trouble over the years. The objective of the present study was to investigate the possibility of changing the recommendations. METHODS: This was a retrospective analysis of the medical records of children operated for biliary atresia in the 1993-2012 period. RESULTS......: mean 129.7 μmol/l (42-334 μmol/l) and 73% (28-97%), respectively. CONCLUSION: The total amount of conjugated bilirubin above 20 μmol/l is sufficient to require further evaluation for biliary atresia. The percentage value is unnecessary and may cause confusion. FUNDING: none. TRIAL REGISTRATION...

  14. Entrepreneurship by any other name: self-sufficiency versus innovation.

    Science.gov (United States)

    Parker Harris, Sarah; Caldwell, Kate; Renko, Maija

    2014-01-01

    Entrepreneurship has been promoted as an innovative strategy to address the employment of people with disabilities. Research has predominantly focused on the self-sufficiency aspect without fully integrating entrepreneurship literature in the areas of theory, systems change, and demonstration projects. Subsequently there are gaps in services, policies, and research in this field that, in turn, have limited our understanding of the support needs and barriers or facilitators of entrepreneurs with disabilities. A thorough analysis of the literature in these areas led to the development of two core concepts that need to be addressed in integrating entrepreneurship into disability employment research and policy: clarity in operational definitions and better disability statistics and outcome measures. This article interrogates existing research and policy efforts in this regard to argue for a necessary shift in the field from focusing on entrepreneurship as self-sufficiency to understanding entrepreneurship as innovation.

  15. Pricing and crude oil self-sufficiency. [Canada

    Energy Technology Data Exchange (ETDEWEB)

    1979-11-01

    How Canada should go about achieving crude oil self-sufficiency and who should develop Canada's petroleum resources are discussed. The degree of urgency and the level of commitment required by government, industry, and consumers are evaluated. What the price should be of Canadian crude oil and who should establish this price are also discussed. The economic aspects of investment, return, and taxation are also included. (DC)

  16. Reassessing Rogers' necessary and sufficient conditions of change.

    Science.gov (United States)

    Watson, Jeanne C

    2007-09-01

    This article reviews the impact of Carl Rogers' postulate about the necessary and sufficient conditions of therapeutic change on the field of psychotherapy. It is proposed that his article (see record 2007-14630-002) made an impact in two ways; first, by acting as a spur to researchers to identify the active ingredients of therapeutic change; and, second, by providing guidelines for therapeutic practice. The role of the necessary and sufficient conditions in process-experiential therapy, an emotion-focused therapy for individuals, and their limitations in terms of research and practice are discussed. It is proposed that although the conditions are necessary and important in promoting clients' affect regulation, they do not take sufficient account of other moderating variables that affect clients' response to treatment and may need to be balanced with more structured interventions. Notwithstanding, Rogers highlighted a way of interacting with clients that is generally acknowledged as essential to effective psychotherapy practice. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

  17. POLITICAL ECONOMIC ANALYSIS OF RICE SELF-SUFFICIENCY IN INDONESIA

    Directory of Open Access Journals (Sweden)

    Sri Nuryanti

    2018-01-01

    Full Text Available Rice self-sufficiency is an important programme in Indonesia. The programme has four major targets, i.e. increasing production, stabilizing prices and reserve stocks, and minimizing import. For that purpose, the government gave a mandate to a parastatal, namely National Logistic Agency (Bulog in implementing the rice policies. Some studies found that involvement of such a parastatal could lead to government failure in budget allocation. The study aimed to estimate social cost of rice self-sufficiency programme based on the implementation of rice instrument policies by Bulog. The study used the national annual data of 2002–2014 period. The method used was the political preference function model to estimate economic rent and dead-weight loss using rice price elasticity of demand and supply. The result showed that in terms of percentage of food security budget, the average of economic rent reached IDR 6.37 trillion per annum (18.54%, while the average of dead-weight loss amounted at IDR 0.90 trillion per annum (2.34%. It proved that rice self-sufficiency programme along with the involvement of Bulog was economically inefficient. The government should provide better agricultural infrastructure, review governmental procurement prices, and stop rice import policy to remedy market failure.

  18. Deuterium-tritium fuel self-sufficiency in fusion reactors

    International Nuclear Information System (INIS)

    Abdou, M.A.; Vold, E.L.; Gung, C.Y.; Youssef, M.Z.; Shin, K.

    1986-01-01

    Conditions necessary to achieve deuterium-tritium fuel self-sufficiency in fusion reactors are derived through extensive modeling and calculations of the required and achievable tritium breeding ratios as functions of the many reactor parameters and candidate design concepts. It is found that the excess margin in the breeding potential is not sufficient to cover all present uncertainties. Thus, the goal of attaining fuel self-sufficiency significantly restricts the allowable parameter space and design concepts. For example, the required breeding ratio can be reduced by (A) attaining high tritium fractional burnup, >5%, in the plasma, (B) achieving very high reliability, >99%, and very short times, <1 day, to fix failures in the tritium processing system, and (C) ensuring that nonradioactive decay losses from all subsystems are extremely low, e.g., <0.1% for the plasma exhaust processing system. The uncertainties due to nuclear data and calculational methods are found to be significant, but they are substantially smaller than those due to uncertainties in system definition

  19. Muscular sufficiency, serum protein, enzymes and bioenergetic studies in chronic malnutrition

    International Nuclear Information System (INIS)

    Gupta, R.K.; Mittal, R.D.; Agarwal, K.N.; Agarwal, D.K.

    1994-01-01

    Muscle sufficiency was significantly lower in 1336 children with chronic malnutrition of moderate to severe degree. 18 children with a chronic moderate degree of malnutrition and 8 well-nourished age-matched controls were selected for biochemical and 31-phosphorus magnetic resonance spectroscopy (31-P MRS) studies. The results shows that: a) serum total protein, albumin, iron, calcium and inorganic phosphate were similar in both groups; b) serum enzyme levels were significantly increased in the malnuourished group; c) 31-P MRS showed significantly higher means for total ATP, β-ATP, α-ATP and inorganic phosphate for the malnourished compared to the control group. In chronic malnutrition, proteins are maintained by degradation in muscle resulting in release of amino acids and enzymes. 31-P MRS studies showing increases in total ATP, β-ATP and inorganic phosphate and a decrease in phosphocreatine suggest that ATP is maintained at the cost of phosphocreatine. 22 refs., 4 tabs. 1 fig

  20. Muscular sufficiency, serum protein, enzymes and bioenergetic studies in chronic malnutrition. [31-phosphorus magnetic resonance spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, R K; Mittal, R D; Agarwal, K N; Agarwal, D K [Banaras Hindu Univ., Varanasi (India)

    1994-03-01

    Muscle sufficiency was significantly lower in 1336 children with chronic malnutrition of moderate to severe degree. 18 children with a chronic moderate degree of malnutrition and 8 well-nourished age-matched controls were selected for biochemical and 31-phosphorus magnetic resonance spectroscopy (31-P MRS) studies. The results shows that: (a) serum total protein, albumin, iron, calcium and inorganic phosphate were similar in both groups; (b) serum enzyme levels were significantly increased in the malnuourished group; (c) 31-P MRS showed significantly higher means for total ATP, [beta]-ATP, [alpha]-ATP and inorganic phosphate for the malnourished compared to the control group. In chronic malnutrition, proteins are maintained by degradation in muscle resulting in release of amino acids and enzymes. 31-P MRS studies showing increases in total ATP, [beta]-ATP and inorganic phosphate and a decrease in phosphocreatine suggest that ATP is maintained at the cost of phosphocreatine. 22 refs., 4 tabs. 1 fig.

  1. Applied physics

    International Nuclear Information System (INIS)

    Anon.

    1980-01-01

    The Physics Division research program that is dedicated primarily to applied research goals involves the interaction of energetic particles with solids. This applied research is carried out in conjunction with the basic research studies from which it evolved

  2. Use of Monte Carlo Bootstrap Method in the Analysis of Sample Sufficiency for Radioecological Data

    International Nuclear Information System (INIS)

    Silva, A. N. C. da; Amaral, R. S.; Araujo Santos Jr, J.; Wilson Vieira, J.; Lima, F. R. de A.

    2015-01-01

    There are operational difficulties in obtaining samples for radioecological studies. Population data may no longer be available during the study and obtaining new samples may not be possible. These problems do the researcher sometimes work with a small number of data. Therefore, it is difficult to know whether the number of samples will be sufficient to estimate the desired parameter. Hence, it is critical do the analysis of sample sufficiency. It is not interesting uses the classical methods of statistic to analyze sample sufficiency in Radioecology, because naturally occurring radionuclides have a random distribution in soil, usually arise outliers and gaps with missing values. The present work was developed aiming to apply the Monte Carlo Bootstrap method in the analysis of sample sufficiency with quantitative estimation of a single variable such as specific activity of a natural radioisotope present in plants. The pseudo population was a small sample with 14 values of specific activity of 226 Ra in forage palm (Opuntia spp.). Using the R software was performed a computational procedure to calculate the number of the sample values. The re sampling process with replacement took the 14 values of original sample and produced 10,000 bootstrap samples for each round. Then was calculated the estimated average θ for samples with 2, 5, 8, 11 and 14 values randomly selected. The results showed that if the researcher work with only 11 sample values, the average parameter will be within a confidence interval with 90% probability . (Author)

  3. "Smoking in Children's Environment Test": a qualitative study of experiences of a new instrument applied in preventive work in child health care

    OpenAIRE

    Carlsson, Noomi; Alehagen, Siw; Andersson G?re, Boel; Johansson, AnnaKarin

    2011-01-01

    Background Despite knowledge of the adverse health effects of passive smoking, children are still   being exposed. Children's nurses play an important role in tobacco preventive work   through dialogue with parents aimed at identifying how children can be protected from   environmental tobacco smoke (ETS) exposure. The study describes the experiences of   Child Health Care (CHC) nurses when using the validated instrument SiCET (Smoking   in Children's Environment Test) in dialogue with parent...

  4. Essays on Applied Microeconomics

    Science.gov (United States)

    Mejia Mantilla, Carolina

    2013-01-01

    Each chapter of this dissertation studies a different question within the field of Applied Microeconomics. The first chapter examines the mid- and long-term effects of the 1998 Asian Crisis on the educational attainment of Indonesian children ages 6 to 18, at the time of the crisis. The effects are identified as deviations from a linear trend for…

  5. Model Informed Pediatric Development Applied to Bilastine: Ontogenic PK Model Development, Dose Selection for First Time in Children and PK Study Design.

    Science.gov (United States)

    Vozmediano, Valvanera; Sologuren, Ander; Lukas, John C; Leal, Nerea; Rodriguez, Mónica

    2017-12-01

    Bilastine is an H 1 antagonist whose pharmacokinetics (PK) and pharmacodynamics (PD) have been resolved in adults with a therapeutic oral dose of 20 mg/day. Bilastine has favorable characteristics for use in pediatrics but the PK/PD and the optimal dose in children had yet to be clinically explored. The purpose is to: (1) Develop an ontogenic predictive model of bilastine PK linked to the PD in adults by integrating current knowledge; (2) Use the model to design a PK study in children; (3) Confirm the selected dose and the study design through the evaluation of model predictability in the first recruited children; (4) Consider for inclusion the group of younger children (design an adaptive PK trial in children that was then confirmed using data from the first recruits by comparing observations with model predictions. PK/PD simulations supported the selection of 10 mg/day in 2 to design hence trial continuation. The model successfully predicted bilastine PK in pediatrics and optimally assisted the selection of the dose and sampling scheme for the trial in children. The selected dose was considered suitable for younger children and the forthcoming safety study in children aged 2 to <12 years.

  6. Effects of a Gluten-Free Diet on Rate of Learning in Autistic Children in an Applied Behavioral Analysis Program: Summary Analysis.

    Science.gov (United States)

    Pontino, Jamie Lyn; Schaal, Kelly; Chambliss, Catherine

    This summary analysis discusses a series of studies that used both between-subjects and within-subjects analyses to examine the effects of a gluten-free diet on the academic achievement of children with autism. In the first study, the between-subjects analysis included data from eight children with autism (ages 5-7), with four on a gluten-free…

  7. Sufficiency and Duality for Multiobjective Programming under New Invexity

    Directory of Open Access Journals (Sweden)

    Yingchun Zheng

    2016-01-01

    Full Text Available A class of multiobjective programming problems including inequality constraints is considered. To this aim, some new concepts of generalized F,P-type I and F,P-type II functions are introduced in the differentiable assumption by using the sublinear function F. These new functions are used to establish and prove the sufficient optimality conditions for weak efficiency or efficiency of the multiobjective programming problems. Moreover, two kinds of dual models are formulated. The weak dual, strong dual, and strict converse dual results are obtained under the aforesaid functions.

  8. On the Necessary and Sufficient Assumptions for UC Computation

    DEFF Research Database (Denmark)

    Damgård, Ivan Bjerre; Nielsen, Jesper Buus; Orlandi, Claudio

    2010-01-01

    for all of them. Perhaps most interestingly we show that: •  For even the minimal meaningful KRA, where we only assume that the secret key is a value which is hard to compute from the public key, one can UC securely compute any poly-time functionality if there exists a passive secure oblivious...... that in the KRA model one-way functions are sufficient for UC commitment and UC zero-knowledge. These are the first examples of UC secure protocols for non-trivial tasks which do not assume the existence of public-key primitives. In particular, the protocols show that non-trivial UC computation is possible...

  9. Pathogens in Sludge: A Case of Sufficient Challenge

    Energy Technology Data Exchange (ETDEWEB)

    Lesilind, R. Aarne

    2003-07-01

    There is increasing pressure in many countries to strengthen the regulations controlling the land disposal of wastewater sludges. In this paper I argue that although there is little doubt that sludges from wastewater treatment contain pathogenic organisms, not only are there no data to show that such disposal is a public health problem, but I want to suggest that small doses of pathogens in the environment provide a ''sufficient challenge'' that actually enhances public health. There therefore seems little reason, from a public health standpoint, to pass stricter sludge disposal regulations. (author)

  10. LDR: A Package for Likelihood-Based Sufficient Dimension Reduction

    Directory of Open Access Journals (Sweden)

    R. Dennis Cook

    2011-03-01

    Full Text Available We introduce a new mlab software package that implements several recently proposed likelihood-based methods for sufficient dimension reduction. Current capabilities include estimation of reduced subspaces with a fixed dimension d, as well as estimation of d by use of likelihood-ratio testing, permutation testing and information criteria. The methods are suitable for preprocessing data for both regression and classification. Implementations of related estimators are also available. Although the software is more oriented to command-line operation, a graphical user interface is also provided for prototype computations.

  11. Stable dynamics in forced systems with sufficiently high/low forcing frequency.

    Science.gov (United States)

    Bartuccelli, M; Gentile, G; Wright, J A

    2016-08-01

    We consider parametrically forced Hamiltonian systems with one-and-a-half degrees of freedom and study the stability of the dynamics when the frequency of the forcing is relatively high or low. We show that, provided the frequency is sufficiently high, Kolmogorov-Arnold-Moser (KAM) theorem may be applied even when the forcing amplitude is far away from the perturbation regime. A similar result is obtained for sufficiently low frequency, but in that case we need the amplitude of the forcing to be not too large; however, we are still able to consider amplitudes which are outside of the perturbation regime. In addition, we find numerically that the dynamics may be stable even when the forcing amplitude is very large, well beyond the range of validity of the analytical results, provided the frequency of the forcing is taken correspondingly low.

  12. Complete self-sufficiency planning: designing and building disaster-ready hospitals.

    Science.gov (United States)

    Brands, Chad K; Hernandez, Raquel G; Stenberg, Arnold; Carnes, Gary; Ellen, Jonathan; Epstein, Michael; Strouse, Timothy

    2013-01-01

    The need for healthcare systems and academic medical centers to be optimally prepared in the event of a disaster is well documented. Events such as Hurricane Katrina demonstrate a major gap in disaster preparedness for at-risk medical institutions. To address this gap, we outline the components of complete self-sufficiency planning in designing and building hospitals that will function at full operational capacity in the event of a disaster. We review the processes used and outcomes achieved in building a new critical access, freestanding children's hospital in Florida. Given that hurricanes are the most frequently occurring natural disaster in Florida, the executive leadership of our hospital determined that we should be prepared for worst-case scenarios in the design and construction of a new hospital. A comprehensive vulnerability assessment was performed. A building planning process that engaged all of the stakeholders was used during the planning and design phases. Subsequent executive-level review and discussions determined that a disaster would require the services of a fully functional hospital. Lessons learned from our own institution's previous experiences and those of medical centers involved in the Hurricane Katrina disaster were informative and incorporated into an innovative set of hospital design elements used for construction of a new hospital with full operational capacity in a disaster. A freestanding children's hospital was constructed using a new framework for disaster planning and preparedness that we have termed complete self-sufficiency planning. We propose the use of complete self-sufficiency planning as a best practice for disaster preparedness in the design and construction of new hospital facilities.

  13. CANDU: Meeting the demand for energy self-sufficiency

    International Nuclear Information System (INIS)

    Lawson, D.S.

    1985-01-01

    The success of the CANDU program can been seen quickly by examining the comparison of typical electricity bills in various provinces of Canada. The provinces of Quebec and Manitoba benefit b extensive hydro electric schemes, many of which were constructed years ago at low capital cost. In Ontario, the economic growth has outstripped these low cost sources of hydro power and hence the province has to rely on thermal sources of electricity generation. The success of the CANDU program is shown by the fact that it can contribute over a third of electricity in Ontario while keeping the total electricity rate comparable with that of those provinces that can rely on low cost hydro sources. Energy self-sufficiency encompasses a spectrum of requirements. One consideration would be the reliable supply and control of fuel during the operating life of a power plant: A greater degree of self-sufficiency would be obtained by having an involvement in the building and engineering of the power plant prior to its operation

  14. Sufficient and necessary condition of separability for generalized Werner states

    International Nuclear Information System (INIS)

    Deng Dongling; Chen Jingling

    2009-01-01

    In a celebrated paper [Optics Communications 179, 447, 2000], A.O. Pittenger and M.H. Rubin presented for the first time a sufficient and necessary condition of separability for the generalized Werner states. Inspired by their ideas, we generalized their method to a more general case. We obtain a sufficient and necessary condition for the separability of a specific class of N d-dimensional system (qudits) states, namely special generalized Werner state (SGWS): W [d N ] (v)=(1-v)(I (N) )/(d N ) +v|ψ d N > d N |, where |ψ d N >=Σ i=0 d-1 α i |i...i> is an entangled pure state of N qudits system and α i satisfies two restrictions: (i) Σ i=0 d-1 α i α i *=1; (ii) Matrix 1/d (I (1) +TΣ i≠j α i |i> j *), where T=Min i≠j {1/|α i α j |}, is a density matrix. Our condition gives quite a simple and efficiently computable way to judge whether a given SGWS is separable or not and previously known separable conditions are shown to be special cases of our approach

  15. Vaccine procurement and self-sufficiency in developing countries.

    Science.gov (United States)

    Woodle, D

    2000-06-01

    This paper discusses the movement toward self-sufficiency in vaccine supply in developing countries (and countries in transition to new economic and political systems) and explains special supply concerns about vaccine as a product class. It traces some history of donor support and programmes aimed at self-financing, then continues with a discussion about self-sufficiency in terms of institutional capacity building. A number of deficiencies commonly found in vaccine procurement and supply in low- and middle-income countries are characterized, and institutional strengthening with procurement technical assistance is described. The paper also provides information about a vaccine procurement manual being developed by the United States Agency for International Development (USAID) and the World Health Organization (WHO) for use in this environment. Two brief case studies are included to illustrate the spectrum of existing capabilities and different approaches to technical assistance aimed at developing or improving vaccine procurement capability. In conclusion, the paper discusses the special nature of vaccine and issues surrounding potential integration and decentralization of vaccine supply systems as part of health sector reform.

  16. Revenue Sufficiency and Reliability in a Zero Marginal Cost Future

    Energy Technology Data Exchange (ETDEWEB)

    Frew, Bethany A.

    2017-04-17

    Features of existing wholesale electricity markets, such as administrative pricing rules and policy-based reliability standards, can distort market incentives from allowing generators sufficient opportunities to recover both fixed and variable costs. Moreover, these challenges can be amplified by other factors, including (1) inelastic demand resulting from a lack of price signal clarity, (2) low- or near-zero marginal cost generation, particularly arising from low natural gas fuel prices and variable generation (VG), such as wind and solar, and (3) the variability and uncertainty of this VG. As power systems begin to incorporate higher shares of VG, many questions arise about the suitability of the existing marginal-cost-based price formation, primarily within an energy-only market structure, to ensure the economic viability of resources that might be needed to provide system reliability. This article discusses these questions and provides a summary of completed and ongoing modelling-based work at the National Renewable Energy Laboratory to better understand the impacts of evolving power systems on reliability and revenue sufficiency.

  17. A low-cost video game applied for training of upper extremity function in children with cerebral palsy: a pilot study.

    Science.gov (United States)

    Jannink, Michiel J A; van der Wilden, Gelske J; Navis, Dorine W; Visser, Gerben; Gussinklo, Jeanine; Ijzerman, Maarten

    2008-02-01

    The aim of the present study was to determine the user satisfaction of the EyeToy for the training of the upper limb in children with cerebral palsy (CP). User satisfaction was measured in 12 children with CP, using a postexperience questionnaire, primarily based on a presence questionnaire. In general, children with CP were satisfied with and motivated by the EyeToy training. In addition, a first evaluation study was performed to determine the effect of this training method on the upper limb function. Ten children with CP were randomly assigned to the intervention (mean age 11 years, 9 months; SD 2,3) and the control group (mean age 12 years, 3 months; SD 3,2). After a treatment period of 6 weeks, the intervention group completed a user satisfaction questionnaire. Functional outcome was measured using the Melbourne Assessment scores. Percentage scores of the Melbourne Assessment of 7 of the 10 children were the same or changed only 1% to 2% from baseline to followup. However, in the experimental group, two children improved more, 9% and 13% respectively. In conclusion, it can be said that the EyeToy is a motivational training tool for the training of children with CP and has the potential to improve upper extremity function.

  18. Renal tract abnormalities missed in a historical cohort of young children with UTI if the NICE and AAP imaging guidelines were applied.

    Science.gov (United States)

    Narchi, Hassib; Marah, Muhaned; Khan, Asad Aziz; Al-Amri, Abdulla; Al-Shibli, Amar

    2015-10-01

    In a historical cohort of children with a urinary tract infection (UTI) who had already undergone all the imaging procedures, the aim was to determine renal tract abnormalities which would have been missed had we implemented the new guidelines from the National Institute for Health and Care Excellence in the United Kingdom (NICE) or the American Academy of Pediatrics (AAP). After a UTI episode, forty-three children (28 females, 65%) aged between 2 months and 2 years presenting at two general hospitals with a febrile UTI before 2008 underwent all the recommended imaging studies predating the new guidelines. Hydronephrosis was defined and graded according to the Society for Fetal Urology (SFU) classification. Hydronephrosis grade II (mild pelvicalyceal dilatation), grade III (moderate dilatation), and grade IV (gross dilatation with thinning of the renal cortex), duplication, vesicoureteral reflux (VUR) grade II and above, renal scarring and reduced renal uptake (<45%) on technetium-99m-labeled dimercaptosuccinic acid (DMSA) scintigraphy were considered significant abnormalities. We calculated the proportion of abnormalities which would have been missed had the new guidelines been used instead. The median of age was 7.6 months (mean 8.7, range 2-24 months), with the majority (n = 37, 86%) being under 1 year of age. Ultrasound (US) showed hydronephrosis in 14 (32%), all grade II. A voiding cystourethrogram (VCUG) was performed in all and showed VUR ≥ grade II in 16 (37%), including eight children (19%) where it was bilateral. DMSA scan showed scarring in 25 children (58%) of whom 11 (26%) had bilateral scars. Reduced differential renal uptake was present in 10 children (23%). Of the 29 children with normal US, 18 (62%) had renal scarring and nine (31%) had VUR ≥ grade II. The NICE guidelines would have missed 63% of the children with VUR ≥ grade II, including a high proportion of grades IV and V VUR, 44% of the children with renal scarring, and 20% of the

  19. Applied Electromagnetics

    Energy Technology Data Exchange (ETDEWEB)

    Yamashita, H; Marinova, I; Cingoski, V [eds.

    2002-07-01

    These proceedings contain papers relating to the 3rd Japanese-Bulgarian-Macedonian Joint Seminar on Applied Electromagnetics. Included are the following groups: Numerical Methods I; Electrical and Mechanical System Analysis and Simulations; Inverse Problems and Optimizations; Software Methodology; Numerical Methods II; Applied Electromagnetics.

  20. Applied Electromagnetics

    International Nuclear Information System (INIS)

    Yamashita, H.; Marinova, I.; Cingoski, V.

    2002-01-01

    These proceedings contain papers relating to the 3rd Japanese-Bulgarian-Macedonian Joint Seminar on Applied Electromagnetics. Included are the following groups: Numerical Methods I; Electrical and Mechanical System Analysis and Simulations; Inverse Problems and Optimizations; Software Methodology; Numerical Methods II; Applied Electromagnetics

  1. Nature exposure sufficiency and insufficiency: The benefits of environmental preservation.

    Science.gov (United States)

    Reddon, John R; Durante, Salvatore B

    2018-01-01

    Increasing industrialization, urbanization, and a failure of many world leaders to appreciate the consequences of climate change are deleteriously impacting quality of life as well as diminishing the prospects for long term survival. Economic competitiveness and corporate profitability often pre-empt environmental concerns. The calving of an iceberg in Antarctica and the hurricane activity in the Caribbean during 2017 are unfortunate illustrations of the continuing escalation of environmental issues. We provide historical and current evidence for the importance of Nature Exposure (NE) and introduce the continuum Nature Exposure Sufficiency (NES) and Insufficiency (NEI). Insufficiency includes impoverished environments (e.g., slums and prisons) where nature exposure is very limited. Nature Exposure Sufficiency (NES) is an optimal amount of exposure to nature where many benefits such as reinvigoration can be obtained by everyone. NES also has several benefits for individuals with various health conditions such as arthritis, dementia, or depression. The benefits of NE are not just derivable from parks, forests, and other natural settings. Interiors of buildings and homes can be enhanced with plants and even pictures or objects from nature. Additionally, there is abundant evidence indicating that virtual and artificial environments depicting nature can provide substantial NE and therefore contribute to general wellbeing. Besides the difficulty in achieving cooperation amongst nations, corporations, and other collectives in developing and implementing long range plans to deal with climate change, there is also sometimes an aversion at the individual level whereby people are unwilling to experience nature due to insects and other discomforts. Such individuals are often averse to supplanting the comforts of home, even temporarily, with inadequate facilities that are seemingly less pleasant than their typical dwellings. We propose using the term Nature Exposure Aversion

  2. [Vitamin-antioxidant sufficiency of winter sports athletes].

    Science.gov (United States)

    Beketova, N A; Kosheleva, O V; Pereverzeva, O G; Vrzhesinskaia, O A; Kodentsova, V M; Solntseva, T N; Khanfer'ian, R A

    2013-01-01

    The sufficiency of 169 athletes (six disciplines: bullet shooting, biathlon, bobsleigh, skeleton, freestyle skiing, snowboarding) with vitamins A, E, C, B2, and beta-carotene has been investigated in April-September 2013. All athletes (102 juniors, mean age--18.5 +/- 0.3 years, and 67 adult high-performance athletes, mean age--26.8 +/- 0.7 years) were sufficiently supplied with vitamin A (70.7 +/- 1.7 mcg/dl). Mean blood serum retinol level was 15% higher the upper limit of the norm (80 mcg/dl) in biathletes while median reached 90.9 mcg/dl. Blood serum level of tocopherols (1.22 +/- 0.03 mg/dl), ascorbic acid (1.06 +/- 0.03 mg/dl), riboflavin (7.1 +/- 0.4 ng/ml), and beta-carotene (25.1 +/- 1.7 mcg/dl) was in within normal range, but the incidence of insufficiency of vitamins E, C, B2, and carotenoid among athletes varied in the range of 0-25, 0-17, 15-67 and 42-75%, respectively. 95% of adults and 80% of younger athletes were sufficiently provided with vitamin E. Vitamin E level in blood serum of juniors involved in skeleton and biathlon was lower by 51 and 72% (p antioxidants (beta-carotene and vitamins E and C). In other sports, the relative quantity of athletes sufficiently supplied with these essential nutrients did not exceed 56%. The quota of supplied with all antioxidants among bullet shooters (31.1%) and bobsledders (23.5%) was significantly (p antioxidant (mainly beta-carotene) was most often recorded among persons engaged in bullet shooting (67%). The simultaneous lack of all three antioxidants was found only in freestylers and bobsledders (about 5%). Decreased level of antioxidants in blood serum in 40% of athletes was combined with vitamin B2 deficiency. The data obtained suggest the necessity to optimize diet vitamin content of all athletes, taking into account the age and gender differences. Contrary to prevailing stereotypes the optimization must involve not only an increase in the consumption of vitamins (vitamins E, B group) and carotenoids, but

  3. Artificial Self-Sufficient P450 in Reversed Micelles

    Directory of Open Access Journals (Sweden)

    Teruyuki Nagamune

    2010-04-01

    Full Text Available Cytochrome P450s are heme-containing monooxygenases that require electron transfer proteins for their catalytic activities. They prefer hydrophobic compounds as substrates and it is, therefore, desirable to perform their reactions in non-aqueous media. Reversed micelles can stably encapsulate proteins in nano-scaled water pools in organic solvents. However, in the reversed micellar system, when multiple proteins are involved in a reaction they can be separated into different micelles and it is then difficult to transfer electrons between proteins. We show here that an artificial self-sufficient cytochrome P450, which is an enzymatically crosslinked fusion protein composed of P450 and electron transfer proteins, showed micelle-size dependent catalytic activity in a reversed micellar system. Furthermore, the presence of thermostable alcohol dehydrogenase promoted the P450-catalyzed reaction due to cofactor regeneration.

  4. The sufficiency assumption of the reasoned approach to action

    Directory of Open Access Journals (Sweden)

    David Trafimow

    2015-12-01

    Full Text Available The reasoned action approach to understanding and predicting behavior includes the sufficiency assumption. Although variables not included in the theory may influence behavior, these variables work through the variables in the theory. Once the reasoned action variables are included in an analysis, the inclusion of other variables will not increase the variance accounted for in behavioral intentions or behavior. Reasoned action researchers are very concerned with testing if new variables account for variance (or how much traditional variables account for variance, to see whether they are important, in general or with respect to specific behaviors under investigation. But this approach tacitly assumes that accounting for variance is highly relevant to understanding the production of variance, which is what really is at issue. Based on the variance law, I question this assumption.

  5. Are emotions necessary and sufficient for making moral judgments?

    Directory of Open Access Journals (Sweden)

    Marco Aurélio Sousa Alves

    2013-07-01

    Full Text Available http://dx.doi.org/10.5007/1677-2954.2013v12n1p113 Jesse Prinz (2006, 2007 claimed that emotions are necessary and sufficient for moral judgments. First of all, I clarify what this claim amounts to. The view that he labels emotionism will then be critically assessed. Prinz marshals empirical findings to defend a series of increasingly strong theses about how emotions are essential for moral judgments. I argue that the empirical support upon which his arguments are based is not only insufficient, but it even suggests otherwise, if properly interpreted. My criticism is then extended to his sentimentalist theory, that accounts for how emotions are integrated into moral judgments. The central problem is that Prinz’s view fails to capture the rational aspect of moral evaluation. I make this failure explicit and defend that some version or other of neosentimentalism is a more promising route.

  6. Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose.

    Directory of Open Access Journals (Sweden)

    Michael M Scott

    Full Text Available The neuronal coordination of metabolic homeostasis requires the integration of hormonal signals with multiple interrelated central neuronal circuits to produce appropriate levels of food intake, energy expenditure and fuel availability. Ghrelin, a peripherally produced peptide hormone, circulates at high concentrations during nutrient scarcity. Ghrelin promotes food intake, an action lost in ghrelin receptor null mice and also helps maintain fasting blood glucose levels, ensuring an adequate supply of nutrients to the central nervous system. To better understand mechanisms of ghrelin action, we have examined the roles of ghrelin receptor (GHSR expression in the mouse hindbrain. Notably, selective hindbrain ghrelin receptor expression was not sufficient to restore ghrelin-stimulated food intake. In contrast, the lowered fasting blood glucose levels observed in ghrelin receptor-deficient mice were returned to wild-type levels by selective re-expression of the ghrelin receptor in the hindbrain. Our results demonstrate the distributed nature of the neurons mediating ghrelin action.

  7. Child Participant Roles in Applied Linguistics Research

    Science.gov (United States)

    Pinter, Annamaria

    2014-01-01

    Children's status as research participants in applied linguistics has been largely overlooked even though unique methodological and ethical concerns arise in projects where children, rather than adults, are involved. This article examines the role of children as research participants in applied linguistics and discusses the limitations of…

  8. Sufficient condition for confinement of static quarks by a vortex condensation mechanism

    International Nuclear Information System (INIS)

    Mack, G.; Petkova, V.B.

    1978-11-01

    We derive a sufficient condition for confinement of static quarks by a vortex condensation mechanism. It admits vortices that are thick at all times at the cost of constraining them to a finite volume Λi whose complement is not simply connected. The confining potential V(L) is estimated in terms of the change of free energy of a system enclosed in Λi which is induced by a change in vorticity (= singular gauge transformation applied to boundary conditions on deltaΛi). For Abelian gauge theories in 3 dimensions the confining Coulomb potential is reproduced as a lower bound. (orig.) [de

  9. Applied superconductivity

    CERN Document Server

    Newhouse, Vernon L

    1975-01-01

    Applied Superconductivity, Volume II, is part of a two-volume series on applied superconductivity. The first volume dealt with electronic applications and radiation detection, and contains a chapter on liquid helium refrigeration. The present volume discusses magnets, electromechanical applications, accelerators, and microwave and rf devices. The book opens with a chapter on high-field superconducting magnets, covering applications and magnet design. Subsequent chapters discuss superconductive machinery such as superconductive bearings and motors; rf superconducting devices; and future prospec

  10. Comparative Characteristics of the Results of Evacuation to Healthcare Facilities and Treatment Outcomes of Children Who Applied for First Aid With Acute Abdominal Pains. The Case of an Emergency Medical Setting of an Average Municipal Entity

    OpenAIRE

    Ekaterina А. Romanova; Leyla S. Namazova-Baranova; Elena Yu. Dyakonova; Aleksey Yu. Romanov; Kazbek S. Mezhidov; Zharadat I. Dohshukaeva

    2017-01-01

    Background. Despite the active development of diagnostic capabilities, the problems of diagnosis at the pre-hospital stage with abdominal pain remain unresolved. Objective. Our aim was to analyze the results of evacuation to healthcare facilities as well as treatment outcomes (conservative and surgical) of hospitalized children who applied for first aid with acute abdominal pain, in order to identify possible shortcomings in the existing diagnostic algorithm and its optimization. Methods. The...

  11. A Randomized Clinical Trial Comparison Between Pivotal Response Treatment (PRT) and Adult-Driven Applied Behavior Analysis (ABA) Intervention on Disruptive Behaviors in Public School Children with Autism.

    Science.gov (United States)

    Mohammadzaheri, Fereshteh; Koegel, Lynn Kern; Rezaei, Mohammad; Bakhshi, Enayatolah

    2015-09-01

    Children with autism often demonstrate disruptive behaviors during demanding teaching tasks. Language intervention can be particularly difficult as it involves social and communicative areas, which are challenging for this population. The purpose of this study was to compare two intervention conditions, a naturalistic approach, Pivotal Response Treatment (PRT) with an adult-directed ABA approach on disruptive behavior during language intervention in the public schools. A randomized clinical trial design was used with two groups of children, matched according to age, sex and mean length of utterance. The data showed that the children demonstrated significantly lower levels of disruptive behavior during the PRT condition. The results are discussed with respect to antecedent manipulations that may be helpful in reducing disruptive behavior.

  12. On necessity and sufficiency in counseling and psychotherapy (revisited).

    Science.gov (United States)

    Lazarus, Arnold A

    2007-09-01

    It seems to me that Carl Rogers (see record 2007-14639-002) was far too ambitious in trying to specify general conditions of necessity and sufficiency that would be relevant to the entire spectrum of problems and the diverse expectancies and personalities of the people who seek our help. Rogers' position and orientation almost totally overlook the array of problems under the rubric of "response deficits" that stem from misinformation and missing information and call for active correction, training, and retraining. Rogers also paid scant attention to problems with significant biological determinants. Nevertheless, as exemplified by his seminal 1957 article and many other articles and books, Rogers made major contributions within the domain of the therapeutic alliance. Today, the scientific emphasis looks at accountability, the need to establish various treatments of choice, and the need to understand their presumed mechanisms. Treatment efficacy and generalizability across different methodologies are now considered key issues. The efficacy narrowing and clinically self-limiting consequences of adhering to one particular school of thought are now self-evident to most. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

  13. Arterial stiffening provides sufficient explanation for primary hypertension.

    Directory of Open Access Journals (Sweden)

    Klas H Pettersen

    2014-05-01

    Full Text Available Hypertension is one of the most common age-related chronic disorders, and by predisposing individuals for heart failure, stroke, and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense research efforts over many decades. By use of empirically well-constrained computer models describing the coupled function of the baroreceptor reflex and mechanics of the circulatory system, we demonstrate quantitatively that arterial stiffening seems sufficient to explain age-related emergence of hypertension. Specifically, the empirically observed chronic changes in pulse pressure with age and the impaired capacity of hypertensive individuals to regulate short-term changes in blood pressure arise as emergent properties of the integrated system. The results are consistent with available experimental data from chemical and surgical manipulation of the cardio-vascular system. In contrast to widely held opinions, the results suggest that primary hypertension can be attributed to a mechanogenic etiology without challenging current conceptions of renal and sympathetic nervous system function.

  14. Evolution favors protein mutational robustness in sufficiently large populations

    Directory of Open Access Journals (Sweden)

    Venturelli Ophelia S

    2007-07-01

    Full Text Available Abstract Background An important question is whether evolution favors properties such as mutational robustness or evolvability that do not directly benefit any individual, but can influence the course of future evolution. Functionally similar proteins can differ substantially in their robustness to mutations and capacity to evolve new functions, but it has remained unclear whether any of these differences might be due to evolutionary selection for these properties. Results Here we use laboratory experiments to demonstrate that evolution favors protein mutational robustness if the evolving population is sufficiently large. We neutrally evolve cytochrome P450 proteins under identical selection pressures and mutation rates in populations of different sizes, and show that proteins from the larger and thus more polymorphic population tend towards higher mutational robustness. Proteins from the larger population also evolve greater stability, a biophysical property that is known to enhance both mutational robustness and evolvability. The excess mutational robustness and stability is well described by mathematical theory, and can be quantitatively related to the way that the proteins occupy their neutral network. Conclusion Our work is the first experimental demonstration of the general tendency of evolution to favor mutational robustness and protein stability in highly polymorphic populations. We suggest that this phenomenon could contribute to the mutational robustness and evolvability of viruses and bacteria that exist in large populations.

  15. Predator confusion is sufficient to evolve swarming behaviour.

    Science.gov (United States)

    Olson, Randal S; Hintze, Arend; Dyer, Fred C; Knoester, David B; Adami, Christoph

    2013-08-06

    Swarming behaviours in animals have been extensively studied owing to their implications for the evolution of cooperation, social cognition and predator-prey dynamics. An important goal of these studies is discerning which evolutionary pressures favour the formation of swarms. One hypothesis is that swarms arise because the presence of multiple moving prey in swarms causes confusion for attacking predators, but it remains unclear how important this selective force is. Using an evolutionary model of a predator-prey system, we show that predator confusion provides a sufficient selection pressure to evolve swarming behaviour in prey. Furthermore, we demonstrate that the evolutionary effect of predator confusion on prey could in turn exert pressure on the structure of the predator's visual field, favouring the frontally oriented, high-resolution visual systems commonly observed in predators that feed on swarming animals. Finally, we provide evidence that when prey evolve swarming in response to predator confusion, there is a change in the shape of the functional response curve describing the predator's consumption rate as prey density increases. Thus, we show that a relatively simple perceptual constraint--predator confusion--could have pervasive evolutionary effects on prey behaviour, predator sensory mechanisms and the ecological interactions between predators and prey.

  16. Syndesmotic Malreduction after Ankle ORIF; Is Radiography Sufficient?

    Directory of Open Access Journals (Sweden)

    Alireza Manafi Rasi

    2013-12-01

    Full Text Available   Background: Ankle fractures, especially those resulting from external rotation mechanisms are associated with injury to the distal tibiofibular syndesmosis. Some authors have recommended performing CT scanning after open ankle surgery to evaluate the reduction of syndesmosis. In this current study, we aimed to investigate the sensitivity of plain radiography in diagnosing syndesmosis malreduction after open reduction and internal fixation (ORIF in patients with ankle fractures.   Methods: Thirty patients with ankle fractures participated in this prospective study. ORIFs were performed with respect to all of the technical guidelines shown in orthopedic literature for exact syndesmosis reduction, such as fibular length and proper settings. In the operating room, plain radiography was performed in anteroposterior, mortise and lateral views to assess whether syndesmosis was malreduced. If malreduction was detected, the patient was revised. As the gold standard, patients underwent postoperative bilateral CT scanning to investigate the syndesmosis reduction which was then compared to the healthy side. Finally, the sensitivity of plain radiography in the diagnosis of syndesmosis malreduction was determined by comparing this method to CT scanning. Results: In both of the methods we did not find any patient with syndesmosis malreduction. Hence, the sensitivity of plain radiography was determined 100%. Conclusion: Based on our findings, there is no need to perform CT scanning to evaluate syndesmosis reduction after ankle ORIF in patients with ankle fractures. Plain radiography is sufficient and has satisfactory sensitivity in these patients.

  17. Syndesmotic Malreduction after Ankle ORIF; Is Radiography Sufficient?

    Directory of Open Access Journals (Sweden)

    Alireza Manafi Rasi

    2013-12-01

    Full Text Available Background: Ankle fractures, especially those resulting from external rotation mechanisms are associated with injury to the distal tibiofibular syndesmosis. Some authors have recommended performing CT scanning after open ankle surgery to evaluate the reduction of syndesmosis. In this current study, we aimed to investigate the sensitivity of plain radiography in diagnosing syndesmosis malreduction after open reduction and internal fixation (ORIF in patients with ankle fractures.   Methods: Thirty patients with ankle fractures participated in this prospective study. ORIFs were performed with respect to all of the technical guidelines shown in orthopedic literature for exact syndesmosis reduction, such as fibular length and proper settings. In the operating room, plain radiography was performed in anteroposterior, mortise and lateral views to assess whether syndesmosis was malreduced. If malreduction was detected, the patient was revised. As the gold standard, patients underwent postoperative bilateral CT scanning to investigate the syndesmosis reduction which was then compared to the healthy side. Finally, the sensitivity of plain radiography in the diagnosis of syndesmosis malreduction was determined by comparing this method to CT scanning. Results: In both of the methods we did not find any patient with syndesmosis malreduction. Hence, the sensitivity of plain radiography was determined 100%. Conclusion: Based on our findings, there is no need to perform CT scanning to evaluate syndesmosis reduction after ankle ORIF in patients with ankle fractures. Plain radiography is sufficient and has satisfactory sensitivity in these patients.

  18. Applied mathematics

    CERN Document Server

    Logan, J David

    2013-01-01

    Praise for the Third Edition"Future mathematicians, scientists, and engineers should find the book to be an excellent introductory text for coursework or self-study as well as worth its shelf space for reference." -MAA Reviews Applied Mathematics, Fourth Edition is a thoroughly updated and revised edition on the applications of modeling and analyzing natural, social, and technological processes. The book covers a wide range of key topics in mathematical methods and modeling and highlights the connections between mathematics and the applied and nat

  19. Applying the bioecological model to understand factors contributing to psychosocial well-being and healthcare of children and adolescents with diabetes mellitus

    NARCIS (Netherlands)

    Hapunda, Given; Abubakar Ali, A.; Van De Vijver, Fons J R

    We discuss the bioecological model of Urie Bronfrenbreener and its application to diabetes care and the psychosocial well-being of children with diabetes in sub-Saharan Africa. Using empirical evidence, this article demonstrates that the bioecological model provides an important framework for

  20. Conspicuous by Their Absence: Studies Comparing and Combining Risperidone and Applied Behavior Analysis to Reduce Challenging Behavior in Children with Autism

    Science.gov (United States)

    Weeden, Marc; Ehrhardt, Kristal; Poling, Alan

    2009-01-01

    Both risperidone, an atypical antipsychotic drug, and function-based behavior-analytic interventions are popular and empirically validated treatments for reducing challenging behavior in children with autism. The kind of research that supports their effectiveness differs, however, and no published study has directly compared their effects or…

  1. Applied Enzymology.

    Science.gov (United States)

    Manoharan, Asha; Dreisbach, Joseph H.

    1988-01-01

    Describes some examples of chemical and industrial applications of enzymes. Includes a background, a discussion of structure and reactivity, enzymes as therapeutic agents, enzyme replacement, enzymes used in diagnosis, industrial applications of enzymes, and immobilizing enzymes. Concludes that applied enzymology is an important factor in…

  2. "Smoking in Children's Environment Test": a qualitative study of experiences of a new instrument applied in preventive work in child health care

    Directory of Open Access Journals (Sweden)

    Carlsson Noomi

    2011-12-01

    Full Text Available Abstract Background Despite knowledge of the adverse health effects of passive smoking, children are still being exposed. Children's nurses play an important role in tobacco preventive work through dialogue with parents aimed at identifying how children can be protected from environmental tobacco smoke (ETS exposure. The study describes the experiences of Child Health Care (CHC nurses when using the validated instrument SiCET (Smoking in Children's Environment Test in dialogue with parents. Method In an intervention in CHC centres in south-eastern Sweden nurses were invited to use the SiCET. Eighteen nurses participated in focus group interviews. Transcripts were reviewed and their contents were coded into categories by three investigators using the method described for focus groups interviews. Results The SiCET was used in dialogue with parents in tobacco preventive work and resulted in focused discussions on smoking and support for behavioural changes among parents. The instrument had both strengths and limitations. The nurses experienced that the SiCET facilitated dialogue with parents and gave a comprehensive view of the child's ETS exposure. This gave nurses the possibility of taking on a supportive role by offering parents long-term help in protecting their child from ETS exposure and in considering smoking cessation. Conclusion Our findings indicate that the SiCET supports nurses in their dialogue with parents on children's ETS exposure at CHC. There is a need for more clinical use and evaluation of the SiCET to determine its usefulness in clinical practice under varying circumstances.

  3. National Energy Plan 1997 - 2010; Sustainable Energy self-sufficiency

    International Nuclear Information System (INIS)

    1997-01-01

    The present revision of the PEN consists of two parts, a diagnosis and a strategy. In the diagnosis; the evolution and the changes are analyzed foreseen in the international and national environments to establish the form like the energy sector is affected and it responds to these conditions. In second part it revises the strategy to incorporate the required adjustments of agreement with the changes in the environment, the demand perspectives and sector and national politics limits. In the international thing, the process of transformation of the system economic World cup will contribute to strengthen the liberalization actions, deregulation and privatization of the economies of the development countries. Great part of the dynamics growth, will be sustained then in the private investment and in an atmosphere of global competition. The formation of regional blocks opens favorable perspectives for new cooperation forms and development of resources. In the case of the American hemisphere and with reference to the energy sector, one has an important potential to improve the self-sufficiency starting from regional supplies, especially starting from fossil resources. This expectation is important for Colombia that has well-known reservations and important potentials in these resources. The tendencies waited in the fossil resources are more favorable for the countries than they can have reservations and growing production of petroleum and of natural gas. Nevertheless, the development of the coal maintains favorable expectations, but with important requirements as for efficiency and quality in the production that it guarantee the positioning in a more and more concerned market. In the environmental thing, the growth foreseen in the consumption of fossil fuels also bears to the increment in the 2010 in the greenhouse gases, at levels between 36% and 49% superiors to those of 1990. That most of this increment will originate in the in the development countries and

  4. Working memory maintenance is sufficient to reduce state anxiety.

    Science.gov (United States)

    Balderston, Nicholas L; Quispe-Escudero, David; Hale, Elizabeth; Davis, Andrew; O'Connell, Katherine; Ernst, Monique; Grillon, Christian

    2016-11-01

    According to the attentional control theory (ACT) proposed by Eysenck and colleagues, anxiety interferes with cognitive processing by prioritizing bottom-up attentional processes over top-down attentional processes, leading to competition for access to limited resources in working memory, particularly the central executive (Eysenck, Derakshan, Santos, & Calvo, ). However, previous research using the n-back working memory task suggests that working memory load also reduces state anxiety. Assuming that similar mechanisms underlie the effect of anxiety on cognition, and the effect of cognition on anxiety, one possible implication of the ACT would suggest that the reduction of state anxiety with increasing working memory load is driven by activation of central executive attentional control processes. We tested this hypothesis using the Sternberg working memory paradigm, where maintenance processes can be isolated from central executive processes (Altamura et al., ; Sternberg, ). Consistent with the n-back results, subjects showed decreased state anxiety during the maintenance period of high-load trials relative to low-load trials, suggesting that maintenance processes alone are sufficient to achieve this state anxiety reduction. Given that the Sternberg task does not require central executive engagement, these results are not consistent with an implication of the ACT where the cognition/anxiety relationship and anxiety/cognition relationship are mediated by similar central executive mechanisms. Instead, we propose an extension of the ACT such that engaging working memory maintenance suppresses state anxiety in a load-dependent manner. Furthermore, we hypothesize that the efficacy of this effect may moderate the effect of trait anxiety on cognition. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

  5. Greater learnability is not sufficient to produce cultural universals.

    Science.gov (United States)

    Rafferty, Anna N; Griffiths, Thomas L; Ettlinger, Marc

    2013-10-01

    Looking across human societies reveals regularities in the languages that people speak and the concepts that they use. One explanation that has been proposed for these "cultural universals" is differences in the ease with which people learn particular languages and concepts. A difference in learnability means that languages and concepts possessing a particular property are more likely to be accurately transmitted from one generation of learners to the next. Intuitively, this difference could allow languages and concepts that are more learnable to become more prevalent after multiple generations of cultural transmission. If this is the case, the prevalence of languages and concepts with particular properties can be explained simply by demonstrating empirically that they are more learnable. We evaluate this argument using mathematical analysis and behavioral experiments. Specifically, we provide two counter-examples that show how greater learnability need not result in a property becoming prevalent. First, more learnable languages and concepts can nonetheless be less likely to be produced spontaneously as a result of transmission failures. We simulated cultural transmission in the laboratory to show that this can occur for memory of distinctive items: these items are more likely to be remembered, but not generated spontaneously once they have been forgotten. Second, when there are many languages or concepts that lack the more learnable property, sheer numbers can swamp the benefit produced by greater learnability. We demonstrate this using a second series of experiments involving artificial language learning. Both of these counter-examples show that simply finding a learnability bias experimentally is not sufficient to explain why a particular property is prevalent in the languages or concepts used in human societies: explanations for cultural universals based on cultural transmission need to consider the full set of hypotheses a learner could entertain and all of

  6. [Effect of vitamin sufficiency on adaptation syndrome in growing rats].

    Science.gov (United States)

    Sidorova, Iu S; Beketova, N A; Vrzhesinskaia, O A; Kodentsova, V M; Kosheleva, O V; Zorin, S N; Selifanov, A V; Mazo, V K

    2014-01-01

    The influence of vitamin supply of growing male -Wistar rats (n=21) with an initial body weight 53,5±0,9 g on their resistance to a single distress induced by the electric shock has been investigated. Control rats within 21 days received a complete semisynthetic diet,providingadequate amounts of vitamins. Combined vitamin deficiency in experimental rats was caused by 5-fold decrease of vitamin mixture amount in the feed and the total vitamin E exclusion from the mixture. On the 21st day, one day before the end of the experiment, both groups of rats were subjected to stress impact (electrocutaneous irritation on paws, 0,4 mA for 8 sec) and then animals were placed in metabolic cages to collect urine. By the end of the experiment, the animals with the combined vitamin deficiency lag behind in growth. Vitamin B2, A, B1 and E liver content decreased in experimental rats by 1,6, 2,3, 4,4 and 15 fold accordingly. Retinol plasma concentration was significantly reduced by 18%, α-tocopherol level - by 5 fold, urinary excretionof riboflavin and 4-pyridoxic acid (vitamin B6 metabolite) was significantly reduced by 6,5 and 2,46 times accordingly. MDA blood plasma concentration and the urinary ratio of oxidized and not oxidized form of 8-hydroxy-2'-deoxy-guanosine did not differ in both groups of rats. Urinary excretion of stress biomarker corticosterone in rats with combined vitamin deficit was 2,5-fold higher than in control rats. Thus, reducing of vitamins supply resulted in an increase of urine corticosterone in stressed rats, that characterized the intensity of general adaptation syndrome. This fact shows the importance of optimal sufficiency with vitamins in nonspecific (general) resistance to stress.

  7. Is there a threshold level of maternal education sufficient to reduce child undernutrition? Evidence from Malawi, Tanzania and Zimbabwe.

    Science.gov (United States)

    Makoka, Donald; Masibo, Peninah Kinya

    2015-08-22

    Maternal education is strongly associated with young child nutrition outcomes. However, the threshold of the level of maternal education that reduces the level of undernutrition in children is not well established. This paper investigates the level of threshold of maternal education that influences child nutrition outcomes using Demographic and Health Survey data from Malawi (2010), Tanzania (2009-10) and Zimbabwe (2005-06). The total number of children (weighted sample) was 4,563 in Malawi; 4,821 children in Tanzania; and 3,473 children in Zimbabwe Demographic and Health Surveys. Using three measures of child nutritional status: stunting, wasting and underweight, we employ a survey logistic regression to analyse the influence of various levels of maternal education on child nutrition outcomes. In Malawi, 45% of the children were stunted, 42% in Tanzania and 33% in Zimbabwe. There were 12% children underweight in Malawi and Zimbabwe and 16% in Tanzania.The level of wasting was 6% of children in Malawi, 5% in Tanzania and 4% in Zimbabwe. Stunting was significantly (p values educational level in all the three countries. Higher levels of maternal education reduced the odds of child stunting, underweight and wasting in the three countries. The maternal threshold for stunting is more than ten years of schooling. Wasting and underweight have lower threshold levels. These results imply that the free primary education in the three African countries may not be sufficient and policies to keep girls in school beyond primary school hold more promise of addressing child undernutrition.

  8. Inhaled corticosteroid treatment for 6?months was not sufficient to normalize phagocytosis in asthmatic children

    OpenAIRE

    da Silva-Martins, Carmen L?via Faria; Couto, Shirley Claudino; Muniz-Junqueira, Maria Imaculada

    2013-01-01

    Background Corticosteroids are the first-line therapy for asthma; however, the effect of corticosteroids on the innate immune system remains unclear. This study?s objective was to evaluate the effect of inhaled corticosteroid therapy (ICT) on phagocytic functions. Methods To evaluate the impact of ICT, the phagocytosis of Saccharomyces cerevisiae by blood monocytes and neutrophils and the production of superoxide anions were assessed before and after three and six months of ICT treatment in 5...

  9. Applied dynamics

    CERN Document Server

    Schiehlen, Werner

    2014-01-01

    Applied Dynamics is an important branch of engineering mechanics widely applied to mechanical and automotive engineering, aerospace and biomechanics as well as control engineering and mechatronics. The computational methods presented are based on common fundamentals. For this purpose analytical mechanics turns out to be very useful where D’Alembert’s principle in the Lagrangian formulation proves to be most efficient. The method of multibody systems, finite element systems and continuous systems are treated consistently. Thus, students get a much better understanding of dynamical phenomena, and engineers in design and development departments using computer codes may check the results more easily by choosing models of different complexity for vibration and stress analysis.

  10. Applied optics

    International Nuclear Information System (INIS)

    Orszag, A.; Antonetti, A.

    1988-01-01

    The 1988 progress report, of the Applied Optics laboratory, of the (Polytechnic School, France), is presented. The optical fiber activities are focused on the development of an optical gyrometer, containing a resonance cavity. The following domains are included, in the research program: the infrared laser physics, the laser sources, the semiconductor physics, the multiple-photon ionization and the nonlinear optics. Investigations on the biomedical, the biological and biophysical domains are carried out. The published papers and the congress communications are listed [fr

  11. Comparative Characteristics of the Results of Evacuation to Healthcare Facilities and Treatment Outcomes of Children Who Applied for First Aid With Acute Abdominal Pains. The Case of an Emergency Medical Setting of an Average Municipal Entity

    Directory of Open Access Journals (Sweden)

    Ekaterina А. Romanova

    2017-01-01

    Full Text Available Background. Despite the active development of diagnostic capabilities, the problems of diagnosis at the pre-hospital stage with abdominal pain remain unresolved. Objective. Our aim was to analyze the results of evacuation to healthcare facilities as well as treatment outcomes (conservative and surgical of hospitalized children who applied for first aid with acute abdominal pain, in order to identify possible shortcomings in the existing diagnostic algorithm and its optimization. Methods. The results of treatment outcomes for children with acute abdominal pain at the pre-hospital stage and evacuation to healthcare facilities by visiting teams for the period 2014–2015. are presented by the example of the State Institution «Engels Emergency Medical Setting». Results. Difficulties in routing children to the necessary healthcare facilities (surgical or somatic are due to the complexities of differential diagnosis of the disease in children with acute abdominal pain at the pre-hospital stage. Conclusion. The main task of the primary care and emergency physician at the pre-hospital stage, whose decision determines the direction of the diagnostic search, timeliness and adequacy of the subsequent treatment measures, is to give a correct assessment of abdominal pain syndrome. 

  12. Sustainability and energy self-sufficiency; overcoming the barriers

    Directory of Open Access Journals (Sweden)

    Rania Abdel Galil

    2015-12-01

    Full Text Available Engendering more positive attitudes to renewable energy is by no means a simple feat. Renewable energy technologies are viewed as radical innovations which necessitate substantial changes in production and consumption patterns, hence often met with resistance from both institutions and individuals. Yet action is needed; global energy consumption is expected to rise by 41% and global carbon dioxide emissions by 29%, with most of the demand and rise coming from emerging economies (BP energy outlook 2035. Further, countries need to meet objectives of reduction of GHG under the United Nations Framework Convention on Climate Change. Renewable energy share in the global energy mix needs to significantly increase in order to reach supply sufficiency, energy security, energy equity and environmental sustainability.Meeting demands of energy is critical for the economic and social development of any country; energy must be secure, accessible and affordable at all levels of society, and any negative impact of energy production and energy use on the environment must be minimized. Middle East energy consumption is expected to grow by 69% whilst production to grow by 32%, with 97% of demand still met by fossil fuels by the end of the 2035. Energy investment of $316 billion will be required in the Middle East and North Africa (MENA between 2015 and 2019 to meet its growing demand for power (Apicorp, 2014. Diversifying energy sources is indeed of interest in the MENA region, spurred by growing demand for power and desalinated water, fluctuating fuel price, GHG emission reduction targets, depleting fossil fuel reserves and advances in renewable energy technology. However, there are many barriers that hinder the adoption of renewable energy technologies worldwide, but more so in the MENA region. These barriers are political, economic, social and technological. With a focus on Europe and MENA, it can be said that these barriers have much in common albeit framing

  13. ADJUNCTIVE THERAPY OF COMMUNITY-ACKUIRED PNEUMONIA: NECESSITY AND SUFFICIENCY

    Directory of Open Access Journals (Sweden)

    L. V. Savchenkova

    2016-01-01

      failures  at both the outpatient  and  inpatient, which  significantly increases the cost of treatment. From the standpoint of evidence-based medicine is justified by the  inclusion in the  treatment of communityacquired pneumonia, only a mucolytic drugs and indications NSAIDs as an antipyretic and analgesic short course. The use of most drugs of pathogenic therapy do not have the evidence base  and  the  efficiency of their  purpose can not  be considered reasonable. In this case, the analysis can serve as a basis for planning a set of measures for improvement of pharmacotherapy community-acquired pneumonia based on the principle of minimal sufficiency

  14. Energy self-sufficient sensory ball screw drive; Energieautarker sensorischer Kugelgewindetrieb

    Energy Technology Data Exchange (ETDEWEB)

    Bertram, Oliver

    2012-07-01

    Nowadays the availability of machine tools plays a decisive role in competition to increase in productivity. From state of the art it arises, that ball screw drives are the most abusive component in feed drives because of abrasive wear. Furthermore condition monitoring enables avoiding unplanned machine failure and increasing the availability of the deployed production facility. Thereby the application of additional sensors allows the direct acquisition of wear correlative measurements. To reduce the required effort for integration and increase the robustness, reliability and clarity in industrial environment energy self-sufficient sensor systems can be applied. In this thesis the development and investigation of an energy self-sufficient sensory ball screw drive with direct measurement of wear correlative pretension for condition monitoring application is described. The prototype measures the pretension with force sensors based on strain gauges. The sensor system includes microcontroller-based electronics for signal processing as well as wireless data transmission with ZigBee-standard. A hybrid system assures the energy supply of the sensor system. On the one hand a stepper motor generator produces electrical energy from the motion energy of the ball screw drive. On the other hand an energy buffer based on super caps is reloaded in stationary position by wireless energy transmission. For verification a prototype system is build up. In measurements the sensory and energetic characteristics of the energy self-sufficient sensor systems are analyzed. Moreover, the functionality of the ball screw drive as well as the signal characteristics of the force sensors are examined for different pretensions. In addition, pretension losses due to wear are established in realized endurance trials, which means that timely maintenance can be planned.

  15. The Effect of Education on Preventive Behaviors of Failure to Thrive in Mothers with Children Aged One to Five Years: Applied Health Belief Model

    Directory of Open Access Journals (Sweden)

    Mahtab Navabi

    2017-04-01

    Full Text Available Abstract Background: One of the common and important health problems is failure to thrive in childhood. The purpose of this study was to determine the effect of education on preventive behaviors of failure to thrive in mothers with children based on health belief model. Materials and Methods: This study is an interventional one in which 100 mothers with children one to five years involved (samples divided into two case and control groups, each of 50 sampling was done by a simple random method. For collecting information, a researcher-made questionnaire based on the health belief model and performance check list were used. Then, case group was trained for one month. 3 months after training, data were gathered and analyzed by Spss20 software. In addition to descriptive statistics, tests such as Chi-square, paired t-test and independent T-test were used. Results: The mean age of case and control was 29.98±5.51 and 25.35±5.30 years old, respectively. The average age of children was 23.31 ± 13.14 and 27.55 ± 14.01months, respectively. Before the intervention, no significant difference was seen between groups. The average score in case group before intervention was as: knowledge(31.87±14.24, perceived susceptibility(64.23±5.86, perceived severity(64.41±9.34, perceived benefits(61.75±6.79, perceived barriers(67.91±8.14, self-efficacy(68.00±7.87, cues to action(44.53±6.82 and action(70.00±9.77. However, after the intervention, significant differences between groups in all variables were obserred. Conclusion: According to the results, education based on health belief model is recommended for promoting preventive behaviors of failure to thrive.

  16. A review of developmental and applied language research on African American children: from a deficit to difference perspective on dialect differences.

    Science.gov (United States)

    Stockman, Ida J

    2010-01-01

    The contemporary practices of delivering speech, language, and hearing services in schools reflect palpable gains in professional sensitivity to linguistic and cultural diversity. This article reviews the dominant research themes on the oral language of African American preschoolers who contribute to such diversity in the United States. Specifically, it contrasts the historical and current frameworks that have guided studies of (a) such children's acquisition and use of English and (b) the strategies used to assess and modify their language. Research initiatives that can expand knowledge about this group are proposed.

  17. Applied geodesy

    International Nuclear Information System (INIS)

    Turner, S.

    1987-01-01

    This volume is based on the proceedings of the CERN Accelerator School's course on Applied Geodesy for Particle Accelerators held in April 1986. The purpose was to record and disseminate the knowledge gained in recent years on the geodesy of accelerators and other large systems. The latest methods for positioning equipment to sub-millimetric accuracy in deep underground tunnels several tens of kilometers long are described, as well as such sophisticated techniques as the Navstar Global Positioning System and the Terrameter. Automation of better known instruments such as the gyroscope and Distinvar is also treated along with the highly evolved treatment of components in a modern accelerator. Use of the methods described can be of great benefit in many areas of research and industrial geodesy such as surveying, nautical and aeronautical engineering, astronomical radio-interferometry, metrology of large components, deformation studies, etc

  18. Applied mathematics

    International Nuclear Information System (INIS)

    Nedelec, J.C.

    1988-01-01

    The 1988 progress report of the Applied Mathematics center (Polytechnic School, France), is presented. The research fields of the Center are the scientific calculus, the probabilities and statistics and the video image synthesis. The research topics developed are: the analysis of numerical methods, the mathematical analysis of the physics and mechanics fundamental models, the numerical solution of complex models related to the industrial problems, the stochastic calculus and the brownian movement, the stochastic partial differential equations, the identification of the adaptive filtering parameters, the discrete element systems, statistics, the stochastic control and the development, the image synthesis techniques for education and research programs. The published papers, the congress communications and the thesis are listed [fr

  19. Elder Abuse by Adult Children: An Applied Ecological Framework for Understanding Contextual Risk Factors and the Intergenerational Character of Quality of Life.

    Science.gov (United States)

    Schiamberg, Lawrence B.; Gans, Daphna

    2000-01-01

    Using an applied ecological model, this study focuses on contextual risk factors of elder abuse. Five levels of environment were used to interpret existing research on risk factors. Configuration of risk factors provides a framework for understanding the intergenerational character of quality of life for older adults, developing recommendations…

  20. Applying the Intervention Mapping protocol to develop a kindergarten-based, family-involved intervention to increase European preschool children's physical activity levels: the ToyBox-study.

    Science.gov (United States)

    De Craemer, M; De Decker, E; De Bourdeaudhuij, I; Verloigne, M; Duvinage, K; Koletzko, B; Ibrügger, S; Kreichauf, S; Grammatikaki, E; Moreno, L; Iotova, V; Socha, P; Szott, K; Manios, Y; Cardon, G

    2014-08-01

    Although sufficient physical activity is beneficial for preschoolers' health, activity levels in most preschoolers are low. As preschoolers spend a considerable amount of time at home and at kindergarten, interventions should target both environments to increase their activity levels. The aim of the current paper was to describe the six different steps of the Intervention Mapping protocol towards the systematic development and implementation of the physical activity component of the ToyBox-intervention. This intervention is a kindergarten-based, family-involved intervention implemented across six European countries. Based on the results of literature reviews and focus groups with parents/caregivers and kindergarten teachers, matrices of change objectives were created. Then, theory-based methods and practical strategies were selected to develop intervention materials at three different levels: (i) individual level (preschoolers); (ii) interpersonal level (parents/caregivers) and (iii) organizational level (teachers). This resulted in a standardized intervention with room for local and cultural adaptations in each participating country. Although the Intervention Mapping protocol is a time-consuming process, using this systematic approach may lead to an increase in intervention effectiveness. The presented matrices of change objectives are useful for future programme planners to develop and implement an intervention based on the Intervention Mapping protocol to increase physical activity levels in preschoolers. © 2014 World Obesity.

  1. TAX BENEFITS FOR REGIONAL BUSINESS: NEED, SUFFICIENCY, EFFICIENCY

    Directory of Open Access Journals (Sweden)

    Irina P. Dovbiy

    2018-03-01

    Full Text Available The article analyzes the tax benefits for the enterprises of Russia. Their analysis is carried out in the context of territorial affiliation of tax benefit. Tax benefits were granted as anti-crisis measures: promotion of entrepreneurship, reduction of informal employment, implementation of investment projects. Their granting was often characterized by haphazard nature. There were cases of abuse in the application of tax benefits. The entrepreneur must be ready to prove their right to benefits. Tax benefits have a triple effect: economic, fiscal-budgetary, social. The state tax policy allowed reducing the level of debt burden for 2016. Simultaneously, the increase in tax and non-tax revenues of the consolidated budgets was ensured. The authors analyze the regional and sectoral tax benefits. They are very diverse, especially for small businesses. This is due to socio-economic differentiation of regions. The magnitude of the regional tax burden is determined by the complex of factors: external and internal. The application of tax benefits is associated with big problems. First of all, this is a concealment of income. Secondly, there is a problem of “double” taxation. Difficulties are also associated with applying individual tax regimes: special economic zones, territories of advanced development. The problem of drawing “out of the shadow” of selfemployed citizens is very acute. There must be a special fee regime for them: there is no guarantee of employment for such citizens. The problems of regional taxation of entrepreneurial activity include, on the one hand, the availability and development of various benefits, and on the other hand, their nonsystem character, the impossibility of identifying and using various mechanisms in the aggregate, for example, the mechanisms for the development of entire industries and social directions in entrepreneurship. The authors emphasize that the conditions in which the modern economy of Russia is

  2. Impact of Market Behavior, Fleet Composition, and Ancillary Services on Revenue Sufficiency

    Energy Technology Data Exchange (ETDEWEB)

    Frew, Bethany [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gallo, Giulia [National Renewable Energy Lab. (NREL), Golden, CO (United States); Brinkman, Gregory [National Renewable Energy Lab. (NREL), Golden, CO (United States); Milligan, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Clark, Kara [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bloom, Aaron [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-06-01

    Revenue insufficiency, or the missing money problem, occurs when the revenues that generators earn from the market are not sufficient to cover both fixed and variable costs to remain in the market and/or justify investments in new capacity, which may be needed for reliability. The near-zero marginal cost of variable renewable generators further exacerbates these revenue challenges. Estimating the extent of the missing money problem in current electricity markets is an important, nontrivial task that requires representing both how the power system operates and how market participants behave. This paper explores the missing money problem using a production cost model that represented a simplified version of the Electric Reliability Council of Texas (ERCOT) energy-only market for the years 2012-2014. We evaluate how various market structures -- including market behavior, ancillary services, and changing fleet compositions -- affect net revenues in this ERCOT-like system. In most production cost modeling exercises, resources are assumed to offer their marginal capabilities at marginal costs. Although this assumption is reasonable for feasibility studies and long-term planning, it does not adequately consider the market behaviors that impact revenue sufficiency. In this work, we simulate a limited set of market participant strategic bidding behaviors by means of different sets of markups; these markups are applied to the true production costs of all gas generators, which are the most prominent generators in ERCOT. Results show that markups can help generators increase their net revenues overall, although net revenues may increase or decrease depending on the technology and the year under study. Results also confirm that conventional, variable-cost-based production cost simulations do not capture prices accurately, and this particular feature calls for proxies for strategic behaviors (e.g., markups) and more accurate representations of how electricity markets work. The

  3. Applying radiation

    International Nuclear Information System (INIS)

    Mallozzi, P.J.; Epstein, H.M.; Jung, R.G.; Applebaum, D.C.; Fairand, B.P.; Gallagher, W.J.; Uecker, R.L.; Muckerheide, M.C.

    1979-01-01

    The invention discloses a method and apparatus for applying radiation by producing X-rays of a selected spectrum and intensity and directing them to a desired location. Radiant energy is directed from a laser onto a target to produce such X-rays at the target, which is so positioned adjacent to the desired location as to emit the X-rays toward the desired location; or such X-rays are produced in a region away from the desired location, and are channeled to the desired location. The radiant energy directing means may be shaped (as with bends; adjustable, if desired) to circumvent any obstruction between the laser and the target. Similarly, the X-ray channeling means may be shaped (as with fixed or adjustable bends) to circumvent any obstruction between the region where the X-rays are produced and the desired location. For producing a radiograph in a living organism the X-rays are provided in a short pulse to avoid any blurring of the radiograph from movement of or in the organism. For altering tissue in a living organism the selected spectrum and intensity are such as to affect substantially the tissue in a preselected volume without injuring nearby tissue. Typically, the selected spectrum comprises the range of about 0.1 to 100 keV, and the intensity is selected to provide about 100 to 1000 rads at the desired location. The X-rays may be produced by stimulated emission thereof, typically in a single direction

  4. Musicoterapia aplicada a niños con síndrome de Down Musicotherapy applied to children with Down's syndrome

    Directory of Open Access Journals (Sweden)

    Eloy Pineda Pérez

    2011-06-01

    Full Text Available INTRODUCCIÓN. El síndrome de Down continúa siendo la enfermedad genética por aberración cromosómica más frecuente. La música se ha utilizado con fines terapéuticos en estos pacientes y se han obtenido buenos resultados, por lo que se decidió aplicarla a un grupo de niños con esta condición genética e investigar la percepción que de ella tienen padres y profesores. MÉTODOS. Se realizó un estudio descriptivo sobre el conocimiento de padres y profesores acerca de la musicoterapia y de los resultados de su aplicación en 18 niños con síndrome de Down matriculados en el Círculo Infantil Especial «Zunzún», en La Habana. Después de 9 meses de aplicación de la terapia se realizó una encuesta a las 12 profesoras y a 18 padres y madres de estos niños. RESULTADOS. Cinco (41,6 % profesoras conocían de la musicoterapia antes de su aplicación, mientras que en los padres el conocimiento fue proporcionalmente menor. Todas las profesoras reconocieron nuevas habilidades en el 100 % de los niños y los avances más importantes fueron el lenguaje, la socialización y el aprendizaje. El 77,7 % de los padres señalaron avances en la socialización, el lenguaje y las habilidades motoras. El 100 % de las educadoras y el 88,8 % de los padres se mostraron satisfechos y desean que se mantenga en la institución. CONCLUSIONES. Existía desconocimiento de esta terapia por parte de profesoras y padres. Se reconocieron avances en diferentes áreas del lenguaje, aprendizaje y la socialización, por lo que se recomienda como método terapéutico desde edades tempranas, para mejorar la calidad de vida del niño y de la familia.INTRODUCTION. The Down's syndrome remains the more frequent genetic disease due to chromosomal aberration. The music has been used with therapeutic aims in these patients obtaining good results, thus we decide its implementation in a group of children presenting with this genetic condition and also to research its perception in

  5. Development of a child head analytical dynamic model considering cranial nonuniform thickness and curvature - Applying to children aged 0-1 years old.

    Science.gov (United States)

    Li, Zhigang; Ji, Cheng; Wang, Lishu

    2018-07-01

    Although analytical models have been used to quickly predict head response under impact condition, the existing models generally took the head as regular shell with uniform thickness which cannot account for the actual head geometry with varied cranial thickness and curvature at different locations. The objective of this study is to develop and validate an analytical model incorporating actual cranial thickness and curvature for child aged 0-1YO and investigate their effects on child head dynamic responses at different head locations. To develop the new analytical model, the child head was simplified into an irregular fluid-filled shell with non-uniform thickness and the cranial thickness and curvature at different locations were automatically obtained from CT scans using a procedure developed in this study. The implicit equation of maximum impact force was derived as a function of elastic modulus, thickness and radius of curvature of cranium. The proposed analytical model are compared with cadaver test data of children aged 0-1 years old and it is shown to be accurate in predicting head injury metrics. According to this model, obvious difference in injury metrics were observed among subjects with the same age, but different cranial thickness and curvature; and the injury metrics at forehead location are significant higher than those at other locations due to large thickness it owns. The proposed model shows good biofidelity and can be used in quickly predicting the dynamics response at any location of head for child younger than 1 YO. Copyright © 2018 Elsevier B.V. All rights reserved.

  6. Rural Villagers’ Quality of Life Improvement by Economic Self-Reliance Practices and Trust in the Philosophy of Sufficiency Economy

    Directory of Open Access Journals (Sweden)

    Piyapong Janmaimool

    2016-08-01

    Full Text Available The concept of economic self-reliance, widely known by Thai people as the philosophy of sufficiency economy, has been widely promoted in rural Thai societies. By practicing this philosophy, it is expected that the citizens’ quality of life and local environments could be sustainably improved. This study aims to explore the contribution of the community practices of the sufficiency economy philosophy to rural villagers’ quality of life improvement, and to investigate potential factors that determine the trust of villagers in the philosophy. With the purpose to propose strategies which could enhance trust and promote villagers’ practices of the philosophy, the study investigated influences of three relevant factors on trust towards the philosophy. Those factors included factors related to cognitive-based trust, factors related to emotional-based trust, and factors related to demographic characteristics. Questionnaire surveys and in-depth interviews with community leaders and local villagers were conducted in the Ban Jamrung community, in Thailand’s Rayong Province. The results of the statistical analysis revealed that the residents who applied the sufficiency economy philosophy in their daily lives experienced a relatively better quality of life. Additionally, it was found that trust in the philosophy could be predicted more by rational factors than by emotional factors. These findings could be utilized to develop strategies to maintain and enhance the trust of the people in the philosophy of sufficiency economy.

  7. Movement opportunities for children in early childhood education and care

    DEFF Research Database (Denmark)

    Munksgaard, Kristian Fahnøe

    (Sundhedsstyrelsen, 2016). Therefor the aim of the study was to examine relevant factors for teachers working in early childhood education and care to consider, when working didactically with enhancing movement opportunities for children. Method: The study was conducted as a Realist Review (Pawson, Greenhalgh...... for preschool children. Relevant factors for preschool teachers to consider are parent involvement in movement activities, being a good role model, providing good physical environments for movement, applying policies and strategies that support movement, assuring sufficient teacher competencies in movement...

  8. [Association between breakfast intake and quality of life among self-sufficient Chilean elderly].

    Science.gov (United States)

    García Milla, Paula; Candia Johns, Priscila; Durán Agüero, Samuel

    2014-10-01

    Elderly people are becoming more prevalent in our country, which studies in this group are relevant. Moreover, the health impact of breakfast consumption is demonstrated in school groups. To determine whether breakfast consumption is associated with better quality of life in self-sufficient Chilean elderly. We interviewed 1,285 elderly (> 60 years) of both sexes. We applied two surveys (food and healthy lifestyles surveys), then an anthropometric evaluation was conducted. 5.6% of older adults does not consume breakfast. Those who consume breakfast had a better quality of life (p = 0.004), specifically in men breakfast intake is associated with lower body mass index (BMI) (p=0.002). Moreover, the results indicate that the proportion of elderly who smokes and does not take breakfast is higher, as well as, greater responsibility in health, nutrition, stress management are greater in those that take breakfast. Finally there was an association between breakfast consumption and better nutrition (p = 0.01) and self-realization (p = 0.005). Consumption of breakfast in older adults is associated with better quality of life. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  9. A step too far? Making health equity interventions in Namibia more sufficient

    Directory of Open Access Journals (Sweden)

    Ithindi Taati

    2003-04-01

    Full Text Available Abstract Background Equality of health status is the health equity goal being pursued in developed countries and advocated by development agencies such as WHO and The Rockefeller Foundation for developing countries also. Other concepts of fair distribution of health such as equity of access to medical care may not be sufficient to equalise health outcomes but, nevertheless, they may be more practical and effective in advancing health equity in developing countries. Methods A framework for relating health equity goals to development strategies allowing progressive redistribution of primary health care resources towards the more deprived communities is formulated. The framework is applied to the development of primary health care in post-independence Namibia. Results In Namibia health equity has been advanced through the progressive application of health equity goals of equal distribution of primary care resources per head, equality of access for equal met need and equality of utilisation for equal need. For practical and efficiency reasons it is unlikely that health equity would have been advanced further or more effectively by attempting to implement the goal of equality of health status. Conclusion The goal of equality of health status may not be appropriate in many developing country situations. A stepwise approach based on progressive redistribution of medical services and resources may be more appropriate. This conclusion challenges the views of health economists who emphasise the need to select a single health equality goal and of development agencies which stress that equality of health status is the most important dimension of health equity.

  10. Maternal obesity and vitamin D sufficiency are associated with cord blood vitamin D insufficiency.

    Science.gov (United States)

    Josefson, Jami L; Feinglass, Joseph; Rademaker, Alfred W; Metzger, Boyd E; Zeiss, Dinah M; Price, Heather E; Langman, Craig B

    2013-01-01

    An inverse relationship between total serum 25-hydroxyvitamin D (25-OH D) and increased adiposity has been established in children, adolescents, and adults. However, the relationship between neonatal adiposity and vitamin D status has not been reported. Both maternal obesity and vitamin D deficiency in pregnancy are common and are associated with adverse pregnancy outcomes. The aim of the study was to determine the relationship between vitamin D levels in mothers and newborns, as influenced by maternal obesity, and evaluate these associations with neonatal adiposity. Sixty-one maternal-neonatal pairs participated in this cross-sectional study at an academic medical center. Mothers had a prepregnancy body mass index that was normal or obese. Maternal and cord blood sera were assayed for 25-OH D, and neonatal body composition was measured by air displacement plethysmography. Mothers had similar and sufficient levels of 25-OH D when measured at 36-38 wk gestation, irrespective of body mass index category (normal weight, 46.05, vs. obese, 49.84 ng/ml; P = not significant). However, cord blood 25-OH D was higher in neonates of normal-weight mothers compared to neonates of obese mothers (27.45 vs. 20.81 ng/ml; P = 0.02). The variance in cord blood 25-OH D was explained by four factors: maternal 25-OH D level, the presence of maternal obesity, maternal age, and neonatal adiposity (r(2) = 0.66). Obese women transfer less 25-OH D to offspring than normal-weight women, despite similar serum levels. Cord blood 25-OH D levels directly correlate to neonatal percentage body fat. These novel findings underscore the evolving relationships between maternal obesity, vitamin D nutritional status, and adiposity in the neonatal period that may influence subsequent childhood and adulthood vitamin D-dependent processes.

  11. An energy self-sufficient public building using integrated renewable sources and hydrogen storage

    International Nuclear Information System (INIS)

    Marino, C.; Nucara, A.; Pietrafesa, M.; Pudano, A.

    2013-01-01

    The control of the use of fossil fuels, major cause of greenhouse gas emissions and climate changes, in present days represents one of Governments' main challenges; particularly, a significant energy consumption is observed in buildings and might be significantly reduced through sustainable design, increased energy efficiency and use of renewable sources. At the moment, the widespread use of renewable energy in buildings is limited by its intrinsic discontinuity: consequently integration of plants with energy storage systems could represent an efficient solution to the problem. Within this frame, hydrogen has shown to be particularly fit in order to be used as an energetic carrier. In this aim, in the paper an energetic, economic and environmental analysis of two different configurations of a self-sufficient system for energy production from renewable sources in buildings is presented. In particular, in the first configuration energy production is carried out by means of photovoltaic systems, whereas in the second one a combination of photovoltaic panels and wind generators is used. In both configurations, hydrogen is used as an energy carrier, in order to store energy, and fuel cells guarantee its energetic reconversion. The analysis carried out shows that, although dimensioned as a stand-alone configuration, the system can today be realized only taking advantage from the incentivizing fares applied to grid-connected systems, that are likely to be suspended in the next future. In such case, it represents an interesting investment, with capital returns in about 15 years. As concerns economic sustainability, in fact, the analysis shows that the cost of the energy unit stored in hydrogen volumes, due to the not very high efficiency of the process, presently results greater than that of directly used one. Moreover, also the starting fund of the system proves to be very high, showing an additional cost with respect to systems lacking of energy storage equal to about 50

  12. Philosophy of sufficiency economy for community-based adaptation to climate change: Lessons learned from Thai case studies

    Directory of Open Access Journals (Sweden)

    Kulvadee Kansuntisukmongkol

    2017-01-01

    Full Text Available Major components within the philosophy of a sufficiency economy include moderation, prudence, and self-immunity together with knowledge and morality. These components were proposed to safeguard local communities from adverse changes and crises. Climatic crises due to global warming can impact upon local agricultural production and consumption systems. Yet, it is still questionable whether communities following the sufficiency economy philosophy can cope with climate change. The objective of this research was to study the coping and adaptive capacity to climate change of local agricultural communities following the sufficiency economy philosophy and to analyze the success factors of adaptation to climate change. The research found five adaptive strategies leading to a resilient livelihood: (1 self-evaluation, (2 diversity dependency, (3 storage and reserve, (4 cooperation, and (5 mobility over space and time. These strategies help to reduce exposure and sensitivity, while increasing adaptive capacity to climate change with the aims of sustainability and adaptation for survival, and protecting natural resource bases for food and settlement security. Moderation, prudence, and self-immunity are critical success factors of adaptation measures, whereas local ecological knowledge with morality is a core enabling factor for adapting to climate change. These factors can be applied in community-based climate change adaptation in the National Adaptation Plan.

  13. 33 CFR 115.30 - Sufficiency of State authority for bridges.

    Science.gov (United States)

    2010-07-01

    ... for bridges. 115.30 Section 115.30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.30 Sufficiency of State authority for bridges. An opinion of the attorney general of the State as to the sufficiency of State...

  14. Applied Linguistics and Primary School Teaching

    Science.gov (United States)

    Ellis, Sue, Ed.; McCartney, Elspeth, Ed.

    2011-01-01

    Modern primary teachers must adapt literacy programmes and ensure efficient learning for all. They must also support children with language and literacy difficulties, children learning English as an additional language and possibly teach a modern foreign language. To do this effectively, they need to understand the applied linguistics research…

  15. Sufficient vitamin K status combined with sufficient vitamin D status is associated with better lower extremity function: a prospective analysis of two knee osteoarthritis cohorts.

    Science.gov (United States)

    Shea, M Kyla; Loeser, Richard F; McAlindon, Timothy E; Houston, Denise K; Kritchevsky, Stephen B; Booth, Sarah L

    2017-10-17

    Vitamins K and D are important for the function of vitamin K-dependent proteins in joint tissues. It is unclear if these nutrients are mutually important to functional outcomes related to knee osteoarthritis (OA). We evaluated the association of vitamin K and D sufficiency with lower-extremity function in the Health, Aging Body Composition Knee OA Sub-study (Health ABC) and conducted a replication analysis in an independent cohort, the Osteoarthritis Initiative (OAI). In Health ABC (60% female, 75±3 years) baseline nutrient status was measured using circulating vitamin K and 25(OH)D. Lower-extremity function was assessed using the short physical performance battery (SPPB) and usual 20-meter gait speed. In the OAI (58% female, 61±9 years), baseline nutrient intake was estimated by food frequency questionnaire. Lower-extremity function was assessed using usual 20-meter gait speed and chair stand completion time. Multivariate mixed models were used to evaluate the association of vitamin K and D status and intake with lower-extremity function over 4-5 years. Health ABC participants with sufficient plasma vitamin K (≥1.0 nmol/L) and serum 25(OH)D (≥50 nmol/L) generally had better SPPB scores and faster usual gait speed over follow-up (p≤0.002). In the OAI, sufficient vitamin K and vitamin D intake combined was associated with overall faster usual gait speed and chair stand completion time over follow-up (p≤0.029). Sufficient vitamin K status combined with sufficient vitamin D status was associated with better lower-extremity function in two knee OA cohorts. These findings merit confirmation in vitamin K and D co-supplementation trials. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  16. Dietary Iodine Sufficiency and Moderate Insufficiency in the Lactating Mother and Nursing Infant: A Computational Perspective.

    Science.gov (United States)

    Fisher, W; Wang, Jian; George, Nysia I; Gearhart, Jeffery M; McLanahan, Eva D

    2016-01-01

    The Institute of Medicine recommends that lactating women ingest 290 μg iodide/d and a nursing infant, less than two years of age, 110 μg/d. The World Health Organization, United Nations Children's Fund, and International Council for the Control of Iodine Deficiency Disorders recommend population maternal and infant urinary iodide concentrations ≥ 100 μg/L to ensure iodide sufficiency. For breast milk, researchers have proposed an iodide concentration range of 150-180 μg/L indicates iodide sufficiency for the mother and infant, however no national or international guidelines exist for breast milk iodine concentration. For the first time, a lactating woman and nursing infant biologically based model, from delivery to 90 days postpartum, was constructed to predict maternal and infant urinary iodide concentration, breast milk iodide concentration, the amount of iodide transferred in breast milk to the nursing infant each day and maternal and infant serum thyroid hormone kinetics. The maternal and infant models each consisted of three sub-models, iodide, thyroxine (T4), and triiodothyronine (T3). Using our model to simulate a maternal intake of 290 μg iodide/d, the average daily amount of iodide ingested by the nursing infant, after 4 days of life, gradually increased from 50 to 101 μg/day over 90 days postpartum. The predicted average lactating mother and infant urinary iodide concentrations were both in excess of 100 μg/L and the predicted average breast milk iodide concentration, 157 μg/L. The predicted serum thyroid hormones (T4, free T4 (fT4), and T3) in both the nursing infant and lactating mother were indicative of euthyroidism. The model was calibrated using serum thyroid hormone concentrations for lactating women from the United States and was successful in predicting serum T4 and fT4 levels (within a factor of two) for lactating women in other countries. T3 levels were adequately predicted. Infant serum thyroid hormone levels were adequately

  17. Enough is as good as a feast - sufficiency as policy. Volume 1

    International Nuclear Information System (INIS)

    Darby, Sarah

    2007-01-01

    The concept of sufficiency has a long history, related as it is to the timeless issues of how best to distribute and use resources. Where energy is concerned, absolute reductions in demand are increasingly seen as necessary in response to climate change and energy security concerns. There is an acknowledgement that, collectively if not individually, humans have gone beyond safe limits in their use of fuels. The relatively wealthy and industrialised nations urgently need to move beyond a primary focus on efficiency to the more contentious issues surrounding demand reduction and sufficiency. The paper considers definitions of energy sufficiency, looks at a recent attempt to model future energy use in terms of efficiency and sufficiency, and discusses quantitative and qualitative aspects of sufficiency and how they might become institutionalised. There are many arguments in favour of sufficiency but they often founder in the face of political requirements for market growth and the employment generated by it. Some options for 'sufficiency policy' are selected, including a focus on energy in relation to livelihoods, energy implications of our use of time and making energy use more transparent

  18. Enough is as good as a feast - sufficiency as policy. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Darby, Sarah [Lower Carbon Futures, Environmental Change Inst., Oxford Univ. Centre for the Environment (United Kingdom)

    2007-07-01

    The concept of sufficiency has a long history, related as it is to the timeless issues of how best to distribute and use resources. Where energy is concerned, absolute reductions in demand are increasingly seen as necessary in response to climate change and energy security concerns. There is an acknowledgement that, collectively if not individually, humans have gone beyond safe limits in their use of fuels. The relatively wealthy and industrialised nations urgently need to move beyond a primary focus on efficiency to the more contentious issues surrounding demand reduction and sufficiency. The paper considers definitions of energy sufficiency, looks at a recent attempt to model future energy use in terms of efficiency and sufficiency, and discusses quantitative and qualitative aspects of sufficiency and how they might become institutionalised. There are many arguments in favour of sufficiency but they often founder in the face of political requirements for market growth and the employment generated by it. Some options for 'sufficiency policy' are selected, including a focus on energy in relation to livelihoods, energy implications of our use of time and making energy use more transparent.

  19. MRI of the small bowel: can sufficient bowel distension be achieved with small volumes of oral contrast?

    International Nuclear Information System (INIS)

    Kinner, Sonja; Kuehle, Christiane A.; Ladd, Susanne C.; Barkhausen, Joerg; Herbig, Sebastian; Haag, Sebastian; Lauenstein, Thomas C.

    2008-01-01

    Sufficient luminal distension is mandatory for small bowel imaging. However, patients often are unable to ingest volumes of currently applied oral contrast compounds. The aim of this study was to evaluate if administration of low doses of an oral contrast agent with high-osmolarity leads to sufficient and diagnostic bowel distension. Six healthy volunteers ingested at different occasions 150, 300 and 450 ml of a commercially available oral contrast agent (Banana Smoothie Readi-Cat, E-Z-EM; 194 mOsmol/l). Two-dimensional TrueFISP data sets were acquired in 5-min intervals up to 45 min after contrast ingestion. Small bowel distension was quantified using a visual five-grade ranking (5 very good distension, 1 = collapsed bowel). Results were statistically compared using a Wilcoxon-Rank test. Ingestion of 450 ml and 300 ml resulted in a significantly better distension than 150 ml. The all-over average distension value for 450 ml amounted to 3.4 (300 ml: 3.0, 150 ml: 2.3) and diagnostic bowel distension could be found throughout the small intestine. Even 45 min after ingestion of 450 ml the jejunum and ileum could be reliably analyzed. Small bowel imaging with low doses of contrast leads to diagnostic distension values in healthy subjects when a high-osmolarity substance is applied. These findings may help to further refine small bowel MRI techniques, but need to be confirmed in patients with small bowel disorders. (orig.)

  20. A Response to Papatola and Lustig's Paper on Navigating a Managed Care Peer Review: Guidance for Clinicians Using Applied Behavior Analysis in the Treatment of Children on the Autism Spectrum.

    Science.gov (United States)

    Kornack, Julie; Herscovitch, Brandon; Williams, Ashley L

    2017-12-01

    In their 2016 article, "Navigating a Managed Care Peer Review: Guidance for Clinicians Using Applied Behavior Analysis [ABA] in the Treatment of Children on the Autism Spectrum," Papatola and Lustig provide an overview of the managed care process, discuss the medical necessity of ABA, and offer guidance to clinicians on how to navigate the managed care peer review process. Given that the authors are employed by a large international health insurance carrier and conduct peer reviews on behalf of that organization, this response seeks to provide guidance from both the clinical and public policy perspectives that reflect best practices in the field of autism treatment. This response is not written with the intention of providing or replacing legal advice; rather, this paper offers health care providers of ABA an essential understanding of some of the laws that govern and support their efforts to secure medically necessary treatment and the mechanisms in place with which to challenge decisions by managed care organizations, health plans, and health insurance issuers that may be contrary to best practices. Finally, suggestions are offered on how to navigate a peer review to ensure optimal outcomes and, when necessary, to lay the groundwork to overturn a funding source decision that does not reflect best practices or the standard of care in ABA-based autism treatment.

  1. Children's (Pediatric) Magnetic Resonance Imaging

    Medline Plus

    Full Text Available ... Jewelry and other accessories should be left at home if possible, or removed prior to the MRI ... she is sufficiently awake to be safely sent home. In general, children who have recently been ill ...

  2. A necessary and sufficient condition for a real quadratic extension to have class number one

    International Nuclear Information System (INIS)

    Alemu, Y.

    1990-02-01

    We give a necessary and sufficient condition for a real quadratic extension to have class number one and discuss the applicability of the result to find the class number one fields with small discriminant. 9 refs, 3 tabs

  3. Sufficient conditions for positivity of non-Markovian master equations with Hermitian generators

    International Nuclear Information System (INIS)

    Wilkie, Joshua; Wong Yinmei

    2009-01-01

    We use basic physical motivations to develop sufficient conditions for positive semidefiniteness of the reduced density matrix for generalized non-Markovian integrodifferential Lindblad-Kossakowski master equations with Hermitian generators. We show that it is sufficient for the memory function to be the Fourier transform of a real positive symmetric frequency density function with certain properties. These requirements are physically motivated, and are more general and more easily checked than previously stated sufficient conditions. We also explore the decoherence dynamics numerically for some simple models using the Hadamard representation of the propagator. We show that the sufficient conditions are not necessary conditions. We also show that models exist in which the long time limit is in part determined by non-Markovian effects

  4. Countrywide Evaluation of the Long-Term Family Self-Sufficiency Plan. Establishing the Baselines

    National Research Council Canada - National Science Library

    Schoeni, Robert

    2002-01-01

    ...) Plan on November 16,1999. The LTFSS Plan consists of 46 projects whose goal is to promote self-sufficiency among families that are participating in the California Work Opportunity and Responsibility to Kids (CalWORKs...

  5. Impact of Market Behavior, Fleet Composition, and Ancillary Services on Revenue Sufficiency

    Energy Technology Data Exchange (ETDEWEB)

    Frew, Bethany

    2016-04-26

    This presentation provides an overview of new and ongoing NREL research that aims to improve our understanding of reliability and revenue sufficiency challenges through modeling tools within a markets framework.

  6. 76 FR 39115 - Notice of Proposed Information Collection: Transformation Initiative Family Self-Sufficiency...

    Science.gov (United States)

    2011-07-05

    ... Information Collection: Transformation Initiative Family Self-Sufficiency Demonstration Small Grants AGENCY... information: Title of Proposal: Notice of Funding Availability for the Transformation Initiative Family Self..., think tanks, consortia, Institutions of higher education accredited by a national or regional...

  7. Transforming the energy system: Why municipalities strive for energy self-sufficiency

    International Nuclear Information System (INIS)

    Engelken, Maximilian; Römer, Benedikt; Drescher, Marcus; Welpe, Isabell

    2016-01-01

    Despite evidence that a rising number of municipalities in Germany are striving for energy self-sufficiency, there is little understanding of the driving factors behind this development. We investigate economic, ecological, social and energy system related factors that drive municipalities to strive for energy self-sufficiency with a focus on electricity supply. The empirical data for this study is based on insights generated through expert interviews (N =19) with mayors, energy experts and scientists as well as a quantitative study among mayors and energy officers (N =109) of German municipalities. Results show that environmental awareness, tax revenues and greater independence from private utilities are positively related to the mayors’ attitude towards the realization of energy self-sufficiency. Furthermore, citizens, the political environment, the mayor's political power, and his/her financial resources are relevant factors for a municipality striving for energy self-sufficiency. Policymakers need to decide whether or not to support mayors in this development. For suitable policy interventions, the results suggest the importance of an integrated approach that considers a combination of identified factors. Finally, we propose a morphological box to structure different aspects of energy self-sufficiency and categorize the present study. - Highlights: • Municipalities striving for energy self-sufficiency can play a key role in the transition of the energy system. • Tax revenues and environmental awareness main drivers behind mayors’ attitude towards energy self-sufficiency. • Citizens and the political environment main influencers of mayors striving for energy self-sufficiency. • 19 expert interviews analyzed for the framework of the study based on the theory of planned behavior (TPB). • 109 mayors and energy officers participated in the quantitative main survey.

  8. Economic Valuation of Sufficient and Guaranteed Irrigation Water Supply for Paddy Farms of Guilan Province

    Directory of Open Access Journals (Sweden)

    Mohammad Kavoosi Kalashami

    2014-08-01

    Full Text Available Cultivation of the strategic crop of rice highly depends to the existence of sufficient and guaranteed irrigation water, and water shortage stresses have irreparable effects on yield and quality of productions. Decrease of the Sefidrud river inflow in Guilan province which is the main source of supplying irrigation water for 171 thousand hectares under rice cropping area of this province, has been challenged sufficient and guaranteed irrigation water supply in many regions of mentioned province. Hence, in present study estimating the value that paddy farmers place on sufficient and guaranteed irrigation water supply has been considered. Economic valuation of sufficient and guaranteed irrigation water supply improves water resource management policies in demand side. Requested data set were obtained on the base of a survey and are collected from 224 paddy farms in rural regions that faced with irrigation water shortages. Then, using open-ended valuation approach and estimation of Tobit model via ML and two stages Heckman approach, eliciting paddy farmers' willingness to pay for sufficient and guaranteed irrigation water supply has been accomplished. Results revealed that farmers in investigated regions willing to pay 26.49 percent more than present costs of providing irrigation water in order to have sufficient and guaranteed irrigation water.

  9. Long-Term Resource Adequacy, Long-Term Flexibility Requirements, and Revenue Sufficiency

    Energy Technology Data Exchange (ETDEWEB)

    Milligan, Michael [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Bloom, Aaron P [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Townsend, Aaron [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Ela, Erik [Electric Power Research Institute; Botterud, Audun [Argonne National Laboratory; Levin, Todd [Argonne National Laboratory

    2018-02-15

    Variable generation (VG) can reduce market prices over time and also the energy that other suppliers can sell in the market. The suppliers that are needed to provide capacity and flexibility to meet the long-term reliability requirements may, therefore, earn less revenue. This chapter discusses the topics of resource adequacy and revenue sufficiency - that is, determining and acquiring the quantity of capacity that will be needed at some future date and ensuring that those suppliers that offer the capacity receive sufficient revenue to recover their costs. The focus is on the investment time horizon and the installation of sufficient generation capability. First, the chapter discusses resource adequacy, including newer methods of determining adequacy metrics. The chapter then focuses on revenue sufficiency and how suppliers have sufficient opportunity to recover their total costs. The chapter closes with a description of the mechanisms traditionally adopted by electricity markets to mitigate the issues of resource adequacy and revenue sufficiency and discusses the most recent market design changes to address these issues.

  10. Trends in causes of death among children under 5 in Bangladesh, 1993-2004: an exercise applying a standardized computer algorithm to assign causes of death using verbal autopsy data

    Directory of Open Access Journals (Sweden)

    Walker Neff

    2011-08-01

    Full Text Available Abstract Background Trends in the causes of child mortality serve as important global health information to guide efforts to improve child survival. With child mortality declining in Bangladesh, the distribution of causes of death also changes. The three verbal autopsy (VA studies conducted with the Bangladesh Demographic and Health Surveys provide a unique opportunity to study these changes in child causes of death. Methods To ensure comparability of these trends, we developed a standardized algorithm to assign causes of death using symptoms collected through the VA studies. The original algorithms applied were systematically reviewed and key differences in cause categorization, hierarchy, case definition, and the amount of data collected were compared to inform the development of the standardized algorithm. Based primarily on the 2004 cause categorization and hierarchy, the standardized algorithm guarantees comparability of the trends by only including symptom data commonly available across all three studies. Results Between 1993 and 2004, pneumonia remained the leading cause of death in Bangladesh, contributing to 24% to 33% of deaths among children under 5. The proportion of neonatal mortality increased significantly from 36% (uncertainty range [UR]: 31%-41% to 56% (49%-62% during the same period. The cause-specific mortality fractions due to birth asphyxia/birth injury and prematurity/low birth weight (LBW increased steadily, with both rising from 3% (2%-5% to 13% (10%-17% and 10% (7%-15%, respectively. The cause-specific mortality rates decreased significantly due to neonatal tetanus and several postneonatal causes (tetanus: from 7 [4-11] to 2 [0.4-4] per 1,000 live births (LB; pneumonia: from 26 [20-33] to 15 [11-20] per 1,000 LB; diarrhea: from 12 [8-17] to 4 [2-7] per 1,000 LB; measles: from 5 [2-8] to 0.2 [0-0.7] per 1,000 LB; injury: from 11 [7-17] to 3 [1-5] per 1,000 LB; and malnutrition: from 9 [6-13] to 5 [2-7]. Conclusions

  11. Ethics in studies on children and environmental health.

    Science.gov (United States)

    Merlo, D F; Knudsen, L E; Matusiewicz, K; Niebrój, L; Vähäkangas, K H

    2007-07-01

    Children, because of age-related reasons, are a vulnerable population, and protecting their health is a social, scientific and emotional priority. The increased susceptibility of children and fetuses to environmental (including genotoxic) agents has been widely discussed by the scientific community. Children may experience different levels of chemical exposure than adults, and their sensitivity to chemical toxicities may be increased or decreased in comparison with adults. Such considerations also apply to unborn (fetal exposure) and newborn (neonatal exposure) children. Therefore, research on children is necessary in both clinical and environmental fields, to provide age-specific relevant data regarding the efficacy and safety of medical treatments, and regarding the assessment of risk from unintended environmental exposure. In this context, the stakeholders are many, including children and their parents, physicians and public health researchers, and the society as a whole, with its ethical, regulatory, administrative and political components. The important ethical issues are information of participants and consent to participate. Follow-up and protection of data (samples and information derived from samples) should be discussed in the context of biobanks, where children obtain individual rights when they become adults. It is important to realise that there are highly variable practices within European countries, which may have, in the past, led to differences in practical aspects of research in children. A number of recommendations are provided for research with children and environmental health. Environmental research with children should be scientifically justified, with sound research questions and valid study protocols of sufficient statistical power, ensuring the autonomy of the child and his/her family at the time of the study and later in life, if data and samples are used for follow-up studies. When children are enrolled, we recommend a consent dyad

  12. Endocarditis - children

    Science.gov (United States)

    Valve infection - children; Staphylococcus aureus - endocarditis - children; Enterococcus - endocarditis- children; Streptococcus viridians - endocarditis - children; Candida - endocarditis - children; Bacterial endocarditis - children; Infective ...

  13. Correlation, necessity, and sufficiency: Common errors in the scientific reasoning of undergraduate students for interpreting experiments.

    Science.gov (United States)

    Coleman, Aaron B; Lam, Diane P; Soowal, Lara N

    2015-01-01

    Gaining an understanding of how science works is central to an undergraduate education in biology and biochemistry. The reasoning required to design or interpret experiments that ask specific questions does not come naturally, and is an essential part of the science process skills that must be learned for an understanding of how scientists conduct research. Gaps in these reasoning skills make it difficult for students to become proficient in reading primary scientific literature. In this study, we assessed the ability of students in an upper-division biochemistry laboratory class to use the concepts of correlation, necessity, and sufficiency in interpreting experiments presented in a format and context that is similar to what they would encounter when reading a journal article. The students were assessed before and after completion of a laboratory module where necessary vs. sufficient reasoning was used to design and interpret experiments. The assessment identified two types of errors that were commonly committed by students when interpreting experimental data. When presented with an experiment that only establishes a correlation between a potential intermediate and a known effect, students frequently interpreted the intermediate as being sufficient (causative) for the effect. Also, when presented with an experiment that tests only necessity for an intermediate, they frequently made unsupported conclusions about sufficiency, and vice versa. Completion of the laboratory module and instruction in necessary vs. sufficient reasoning showed some promise for addressing these common errors. © 2015 The International Union of Biochemistry and Molecular Biology.

  14. Information trimming: Sufficient statistics, mutual information, and predictability from effective channel states

    Science.gov (United States)

    James, Ryan G.; Mahoney, John R.; Crutchfield, James P.

    2017-06-01

    One of the most basic characterizations of the relationship between two random variables, X and Y , is the value of their mutual information. Unfortunately, calculating it analytically and estimating it empirically are often stymied by the extremely large dimension of the variables. One might hope to replace such a high-dimensional variable by a smaller one that preserves its relationship with the other. It is well known that either X (or Y ) can be replaced by its minimal sufficient statistic about Y (or X ) while preserving the mutual information. While intuitively reasonable, it is not obvious or straightforward that both variables can be replaced simultaneously. We demonstrate that this is in fact possible: the information X 's minimal sufficient statistic preserves about Y is exactly the information that Y 's minimal sufficient statistic preserves about X . We call this procedure information trimming. As an important corollary, we consider the case where one variable is a stochastic process' past and the other its future. In this case, the mutual information is the channel transmission rate between the channel's effective states. That is, the past-future mutual information (the excess entropy) is the amount of information about the future that can be predicted using the past. Translating our result about minimal sufficient statistics, this is equivalent to the mutual information between the forward- and reverse-time causal states of computational mechanics. We close by discussing multivariate extensions to this use of minimal sufficient statistics.

  15. How, When, and Where? Assessing Renewable Energy Self-Sufficiency at the Neighborhood Level.

    Science.gov (United States)

    Grosspietsch, David; Thömmes, Philippe; Girod, Bastien; Hoffmann, Volker H

    2018-02-20

    Self-sufficient decentralized systems challenge the centralized energy paradigm. Although scholars have assessed specific locations and technological aspects, it remains unclear how, when, and where energy self-sufficiency could become competitive. To address this gap, we develop a techno-economic model for energy self-sufficient neighborhoods that integrates solar photovoltaics (PV), conversion, and storage technologies. We assess the cost of 100% self-sufficiency for both electricity and heat, comparing different technical configurations for a stylized neighborhood in Switzerland and juxtaposing these findings with projections on market and technology development. We then broaden the scope and vary the neighborhood's composition (residential share) and geographic position (along different latitudes). Regarding how to design self-sufficient neighborhoods, we find two promising technical configurations. The "PV-battery-hydrogen" configuration is projected to outperform a fossil-fueled and grid-connected reference configuration when energy prices increase by 2.5% annually and cost reductions in hydrogen-related technologies by a factor of 2 are achieved. The "PV-battery" configuration would allow achieving parity with the reference configuration sooner, at 21% cost reduction. Additionally, more cost-efficient deployment is found in neighborhoods where the end-use is small commercial or mixed and in regions where seasonal fluctuations are low and thus allow for reducing storage requirements.

  16. Conservatism in methodologies for moderator subcooling sufficiency for fuel channel integrity upon pressure tube and calandria tube contact

    Energy Technology Data Exchange (ETDEWEB)

    Sun, L., E-mail: LSun@nbpower.com [Point Lepreau Generating Station, Lepreau, NB, (Canada)

    2015-07-01

    During a postulated large LOCA event in CANDU reactors, the pressure tube may balloon to contact with its surrounding calandria tube to transfer heat to the moderator. To confirm the integrity of the fuel channel in this case, many experiments have been performed in the last three decades. Based on the extant database of the pressure tube/calandria tube (PT/CT) contact, an analytical methodology was developed by Canadian Nuclear Industry to determine the sufficiency of moderator subcooling for fuel channel integrity. At the same time a semi-empirical methodology with an idea of Equivalent Moderator Subcooling (EMS) was also developed to judge the sufficiency of the moderator. In this work, some discussions were made over the two methodologies on their conservatism and it is demonstrated that the analytical approach is over conservative comparing with the EMS methodology. By using the EMS methodology, it is demonstrated that applying glass-peened calandria tubes, the requirement to moderator subcooling can be reduced by 10{sup o}C from that for smooth calandria tubes. (author)

  17. Role of exponential type random invexities for asymptotically sufficient efficiency conditions in semi-infinite multi-objective fractional programming.

    Science.gov (United States)

    Verma, Ram U; Seol, Youngsoo

    2016-01-01

    First a new notion of the random exponential Hanson-Antczak type [Formula: see text]-V-invexity is introduced, which generalizes most of the existing notions in the literature, second a random function [Formula: see text] of the second order is defined, and finally a class of asymptotically sufficient efficiency conditions in semi-infinite multi-objective fractional programming is established. Furthermore, several sets of asymptotic sufficiency results in which various generalized exponential type [Formula: see text]-V-invexity assumptions are imposed on certain vector functions whose components are the individual as well as some combinations of the problem functions are examined and proved. To the best of our knowledge, all the established results on the semi-infinite aspects of the multi-objective fractional programming are new, which is a significantly new emerging field of the interdisciplinary research in nature. We also observed that the investigated results can be modified and applied to several special classes of nonlinear programming problems.

  18. A solar house self-sufficient of energy. Experiences on the way to energy autarky

    International Nuclear Information System (INIS)

    Voss, K.; Dohlen, K. v.; Lehmberg, H.; Stahl, W.; Wittwer, C.; Goetzberger, A.

    1994-01-01

    The solar house Freiburg which is self-sufficient of energy was completed in October 1992. After a long and complex planning phase now measuring and monitoring tasks as well as the realization fo improvement measures are to the fore. This article presents exemplary results of the first year of operation and compare them with the expectations. Self-sufficient operation of the building could be attained between April and October 1993. Here among others hydrogen was successfully produced by photovoltaic supplied electrolysis and was to a large degree used for thermal applications (cooking, heating). The fact that the supply of energy was not self-sufficient all the year round was due to the failure of the fuel cell used to produce electric power again with hydrogen. (orig./BWI) [de

  19. Sufficient education attainment for a decent standard of living in modern Australia

    Directory of Open Access Journals (Sweden)

    Emily Joy Callander

    2012-06-01

    Full Text Available Education attainment will impact upon an individual’s capacity to engage in the labour force, their living standards and hence their poverty status. As such, education should be included in measures of poverty. However, it is not known what a sufficient level of education to have a decent standard of living is. Using the 2003 Survey of Disability, Ageing and Carers different levels of education attainment were tested for their association with labour force participation and income. Based upon this, it was concluded that Year 12 or higher is a sufficient level of education attainment for 15 to 64 year olds; and Year 10 or higher for people over the age of 65 years. This is in line with current government policies to improve Year 12 completion rates. Knowing what a ‘sufficient level of education attainment’ is, allows education to be included in multidimensional measures of poverty that view education as a key dimension of disadvantage.

  20. Energy conservation and self-sufficiency in rural property; Geracao e auto-suficiencia de energias em imovel rural familiar

    Energy Technology Data Exchange (ETDEWEB)

    Schuch, Sergio Luis [Instituto Paranaense de Assistencia Tecnica e Extensao Rural (EMATER), Toledo, PR (Brazil)], e-mail: slschuch@hotmail.com; Lawder, Jose Henrique [Evolucao Engenharia Eletrica, Toledo, PR (Brazil)], e-mail: jose_lawder@uol.com.br; Feiden, Armin; Nogueira, Carlos Eduardo Camargo; Siqueira, Jair Antonio Cruz [Universidade Estadual do Oeste do Parana (UNIOESTE), Cascavel, PR (Brazil)], e-mails: armin_feiden@yahoo.com.br, cecn1@yahoo.com.br, jairsiqueira@unioeste.br

    2011-07-01

    This paper aims to highlight an innovative system designed to generate bioenergy in Toledo - PR, applied in a rural residential property. This system is composed by a simple digester model, because it eliminates masonry and hood storage. Cattle slurry and water from barn's floor cleaning are conducted to an anaerobic biodigester chamber. Biogas production is stored in a polypropylene canvas balloon. After compression, the biogas is used to replace liquefied petroleum gas in central water heating and cooking foods. The wood used in sugar cane molasses has been replaced with higher efficiency by biogas. Also was installed Otto engine providing thermal and electrical power generation at the same time. The electrical power output is biphasic and about 70 Amperes. This system deployed in rural property provides energy self-sufficiency and contribute to the reduction of operational costs of the property. (author)

  1. Energy conservation and self-sufficiency in rural property; Geracao e auto-suficiencia de energias em imovel rural familiar

    Energy Technology Data Exchange (ETDEWEB)

    Schuch, Sergio Luis [Instituto Paranaense de Assistencia Tecnica e Extensao Rural (EMATER), Toledo, PR (Brazil)], e-mail: slschuch@hotmail.com; Lawder, Jose Henrique [Evolucao Engenharia Eletrica, Toledo, PR (Brazil)], e-mail: jose_lawder@uol.com.br; Feiden, Armin; Nogueira, Carlos Eduardo Camargo; Siqueira, Jair Antonio Cruz [Universidade Estadual do Oeste do Parana (UNIOESTE), Cascavel, PR (Brazil)], e-mails: armin_feiden@yahoo.com.br, cecn1@yahoo.com.br, jairsiqueira@unioeste.br

    2011-07-01

    This paper aims to highlight an innovative system designed to generate bioenergy in Toledo - PR, applied in a rural residential property. This system is composed by a simple digester model, because it eliminates masonry and hood storage. Cattle slurry and water from barn's floor cleaning are conducted to an anaerobic biodigester chamber. Biogas production is stored in a polypropylene canvas balloon. After compression, the biogas is used to replace liquefied petroleum gas in central water heating and cooking foods. The wood used in sugar cane molasses has been replaced with higher efficiency by biogas. Also was installed Otto engine providing thermal and electrical power generation at the same time. The electrical power output is biphasic and about 70 Amperes. This system deployed in rural property provides energy self-sufficiency and contribute to the reduction of operational costs of the property. (author)

  2. [Effect of vitamin beverages on vitamin sufficiency of the workers of Pskov Hydroelectric Power-Plant].

    Science.gov (United States)

    Spiricheva, T V; Vrezhesinskaia, O A; Beketova, N A; Pereverzeva, O G; Kosheleva, O V; Kharitonchik, L A; Kodentsova, V M; Iudina, A V; Spirichev, V B

    2010-01-01

    The research of influence of vitamin complexes in the form of a drink or kissel on vitamin sufficiency of working persons has been carried out. Long inclusion (6,5 months) in a diet of vitamin drinks containing about 80% from recommended daily consumption of vitamins, was accompanied by trustworthy improvement of vitamins C and B6 sufficiency and prevention of seasonal deterioration of beta-carotene status. As initially surveyed have been well provided with vitamins A and E, their blood serum level increase had not occurred.

  3. PENENTUAN CADANGAN PREMI DENGAN METODE PREMIUM SUFFICIENCY PADA ASURANSI JIWA SEUMUR HIDUP JOINT LIFE

    OpenAIRE

    NI PUTU MIRAH PERMATASARI; I NYOMAN WIDANA; KARTIKA SARI

    2016-01-01

    The aim of this research was to get the formula of premium reserves through the premium sufficiency method. Premium reserve is the amount of fund that is collected by the insurance company in preparation for the claim’s payment. Premium sufficiency method is gross premium calculation. To construct that formula, this research used Tabel Mortalitas Indonesia (TMI) 2011, interest rate 2.5% and cost of alpha %. Based on simulation result in men premium reserve value of age 1 of 56 years propotio...

  4. PENENTUAN CADANGAN PREMI DENGAN METODE PREMIUM SUFFICIENCY PADA ASURANSI JIWA SEUMUR HIDUP JOINT LIFE

    Directory of Open Access Journals (Sweden)

    NI PUTU MIRAH PERMATASARI

    2016-08-01

    Full Text Available The aim of this research was to get the formula of premium reserves through the premium sufficiency method. Premium reserve is the amount of fund that is collected by the insurance company in preparation for the claim’s payment. Premium sufficiency method is gross premium calculation. To construct that formula, this research used Tabel Mortalitas Indonesia (TMI 2011, interest rate 2.5% and cost of alpha %. Based on simulation result in men premium reserve value of age 1 of 56 years propotional with insured periods, but after56 years enhancement of premium reserve value.

  5. EVALUATION OF FOOD SELF-SUFFICIENCY OF THE REPUBLIC OF TATARSTAN DISTRICTS

    Directory of Open Access Journals (Sweden)

    R. E. Mansurov

    2017-01-01

    Full Text Available The article presents the author's method for estimation of the level of food self-sufficiency for the main types of food products in the regions of Republic of Tatarstan. The proposed method is based on the use of analytical methods and mathematical comparative analysis to compose a final rating. The proposed method can be used in the system of regional management of agro-industrial complex on the federal and local level. Relevance. The relevance of this work is caused by on the one hand a hardening of foreign policy that may negatively impact on national food security, and on the other hand the state crisis of the domestic agricultural sector. All this requires the development of new approaches to regional agribusiness management. Goal. To develop a methodology is used to assess the level of food self-sufficiency. To rate the level of self-sufficiency in main types of foodstuff in regions of Republic of Tatarstan. Materials and Methods. Statistical data of the results of the AIC of the Republic of Tatarstan for 2016 was used for the study. Analytical methods, including mathematical analysis and comparison were used. Results. Based on the analysis of the present situation for ensuring of food security in Russia it was shown that now it is necessary to develop effective indicators identifying the level of self-sufficiency in basic food regions. It was also revealed that there are no such indicators in system of regional agrarian and industrial complex at present time. As a result of analysis existing approaches the author's method of rating the level of self-sufficiency of regions was offered. This method was adopted on the example of the Republic of Tatarstan. Conclusions. The proposed method of rating estimation of self-sufficiency for basic foodstuffs can be used in the regional agroindustrial complex management system at the federal and local level. It can be used to rank areas in terms of their self-sufficiency for basic foodstuffs. This

  6. Operation of CANDU power reactor in thorium self-sufficient fuel cycle

    Indian Academy of Sciences (India)

    These disadvantages of thorium fuel cycle were seemingly the reasons why that ... According to the data of figure 2, maximum (equilibrium) content of 233U in ..... Self-sufficient mode is related with rather big effort in the extraction of isotopes of.

  7. Evaluating the sufficiency of protected lands for maintaining wildlife population connectivity in the northern Rocky Mountains

    Science.gov (United States)

    Samuel A. Cushman; Erin L. Landguth; Curtis H. Flather

    2012-01-01

    Aim: The goal of this study was to evaluate the sufficiency of the network of protected lands in the U.S. northern Rocky Mountains in providing protection for habitat connectivity for 105 hypothetical organisms. A large proportion of the landscape...

  8. Can British Columbia Achieve Electricity Self-Sufficiency and Meet its Renewable Portfolio Standard?

    NARCIS (Netherlands)

    Sopinka, A.; Kooten, van G.C.; Wong, L.

    2012-01-01

    British Columbia’s energy policy is at a crossroads; the province has set a goal of electricity self-sufficiency, a 93% renewable portfolio standard and provincial natural gas strategy that could increase electricity consumption by 2,500-3,800 MW. To ascertain the reality of BC’s supply position, we

  9. The sufficient condition for an extremum in the classical action integral as an eingenvalue problem

    International Nuclear Information System (INIS)

    Hussein, M.S.; Pereira, J.G.

    The sufficient condition for an extremum in the classical action integral is studied using Morse's theory. Applications to the classical harmonic and anharmonic oscillators are made. The analogy of the calculations to the quantum mechanical problems in one dimension is stressed. (Author) [pt

  10. Sufficient condition for black-hole formation in spherical gravitational collapse

    International Nuclear Information System (INIS)

    Giambo, Roberto; Giannoni, Fabio; Magli, Giulio

    2002-01-01

    A sufficient condition for the validity of cosmic censorship in spherical gravitational collapse is formulated and proved. The condition relies on an attractive mathematical property of the apparent horizon, which holds if 'minimal' requirements of physical reasonableness are satisfied by the matter model. (letter to the editor)

  11. Sufficient conditions for BIBO robust stabilization : given by the gap metric

    NARCIS (Netherlands)

    Zhu, S.Q.; Hautus, M.L.J.; Praagman, C.

    1987-01-01

    A relation between coprlme fractions and the gap metric is presented. Using this result we provide some sufficient conditions for BIBO robust stabilization for a very wide class of systems. These conditions allow the plant and compensator to be disturbed simultaneously. Keywords: Robust

  12. Sufficient conditions for robust BIBO stabilization : given by the gap metric

    NARCIS (Netherlands)

    Zhu, S.Q.; Hautus, M.L.J.; Praagman, C.

    1988-01-01

    A relation between coprime fractions and the gap metric is presented. Using this result we provide some sufficient conditions for robust BIBO stabilization for a wide class of systems. These conditions allow the plant and the compensator to be disturbed simultaneously.

  13. Necessary and sufficient conditions for Hopf bifurcation in tri-neuron equation with a delay

    International Nuclear Information System (INIS)

    Liu Xiaoming; Liao Xiaofeng

    2009-01-01

    In this paper, we consider the delayed differential equations modeling three-neuron equations with only a time delay. Using the time delay as a bifurcation parameter, necessary and sufficient conditions for Hopf bifurcation to occur are derived. Numerical results indicate that for this model, Hopf bifurcation is likely to occur at suitable delay parameter values.

  14. Identification of necessary and sufficient conditions for real non-negativeness of rational matrices

    International Nuclear Information System (INIS)

    Saeed, K.

    1982-12-01

    The necessary and sufficient conditions for real non-negativeness of rational matrices have been identified. A programmable algorithm is developed and is given with its computer flow chart. This algorithm can be used as a general solution to test the real non-negativeness of rational matrices. The computer program assures the feasibility of the suggested algorithm. (author)

  15. An immobilized and highly stabilized self-sufficient monooxygenase as biocatalyst for oxidative biotransformations

    NARCIS (Netherlands)

    Valencia, Daniela; Guillén, Marina; Fürst, Maximilian; Josep, López-Santín; Álvaro, Gregorio

    BACKGROUND The requirement of expensive cofactors that must be efficiently recycled is one of the major factors hindering the wide implementation of industrial biocatalytic oxidation processes. In this research, a sustainable approach based on immobilized self-sufficient Baeyer-Villiger

  16. Mating motives are neither necessary nor sufficient to create the beauty premium.

    Science.gov (United States)

    Hafenbrädl, Sebastian; Dana, Jason

    2017-01-01

    Mating motives lead decision makers to favor attractive people, but this favoritism is not sufficient to create a beauty premium in competitive settings. Further, economic approaches to discrimination, when correctly characterized, could neatly accommodate the experimental and field evidence of a beauty premium. Connecting labor economics and evolutionary psychology is laudable, but mating motives do not explain the beauty premium.

  17. Necessary and sufficient conditions for the quantum Zeno and anti-Zeno effect

    International Nuclear Information System (INIS)

    Atmanspacher, Harald; Ehm, Werner; Gneiting, Tilmann

    2003-01-01

    A necessary and sufficient condition for the occurrence of the quantum Zeno effect is given, refining a recent conjecture of Luo, Wang and Zhang. An analogous condition is derived for the quantum anti-Zeno effect. Both results rely on a formal connection between the quantum (anti-)Zeno effect and the weak law of large numbers

  18. Necessary and Sufficient Condition for Local Exponential Synchronization of Nonlinear Systems

    NARCIS (Netherlands)

    Andrieu, Vincent; Jayawardhana, Bayu; Tarbouriech, Sophie

    2015-01-01

    Based on recent works on transverse exponential stability, some necessary and sufficient conditions for the existence of a (locally) exponential synchronizer are established. We show that the existence of a structured synchronizer is equivalent to the existence of a stabilizer for the individual

  19. Sufficient Flexibility and Capacity in Electricity Markets with Renewables: A Review of Innovative Market Mechanisms

    DEFF Research Database (Denmark)

    Sekamane, Jonas Khubute; Katz, Jonas; Skytte, Klaus

    2017-01-01

    This review of the literature collects innovative market mechanisms that tend to get overlooked in the discussion of whether unassisted energy-only markets can ensure sufficient capacity or if capacity remuneration mechanisms are required. The paper complements existing literature reviews...... and pinpoints advantageous research areas relating to the market design of electricity systems with high shares of variable renewable energy...

  20. Necessary and Sufficient Conditions for Pareto Optimality in Infinite Horizon Cooperative Differential Games

    NARCIS (Netherlands)

    Reddy, P.V.; Engwerda, J.C.

    2011-01-01

    In this article we derive necessary and sufficient conditions for the existence of Pareto optimal solutions for infinite horizon cooperative differential games. We consider games defined by non autonomous and discounted autonomous systems. The obtained results are used to analyze the regular

  1. Implementing necessary and sufficient standards for radioactive waste management at LLNL

    International Nuclear Information System (INIS)

    Sims, J.M.; Ladran, A.; Hoyt, D.

    1995-01-01

    Lawrence Livermore National Laboratory (LLNL) and the U.S. Department of Energy, Oakland Field Office (DOE/OAK), are participating in a pilot program to evaluate the process to develop necessary and sufficient sets of standards for contractor activities. This concept of contractor and DOE jointly and locally deciding on what constitutes the set of standards that are necessary and sufficient to perform work safely and in compliance with federal, state, and local regulations, grew out of DOE's Department Standards Committee (Criteria for the Department's Standards Program, August 1994, DOE/EH/-0416). We have chosen radioactive waste management activities as the pilot program at LLNL. This pilot includes low-level radioactive waste, transuranic (TRU) waste, and the radioactive component of low-level and TRU mixed wastes. Guidance for the development and implementation of the necessary and sufficient set of standards is provided in open-quotes The Department of Energy Closure Process for Necessary and Sufficient Sets of Standards,close quotes March 27, 1995 (draft)

  2. Faculty Sufficiency and AACSB Accreditation Compliance within a Global University: A Mathematical Modeling Approach

    Science.gov (United States)

    Boronico, Jess; Murdy, Jim; Kong, Xinlu

    2014-01-01

    This manuscript proposes a mathematical model to address faculty sufficiency requirements towards assuring overall high quality management education at a global university. Constraining elements include full-time faculty coverage by discipline, location, and program, across multiple campus locations subject to stated service quality standards of…

  3. Sufficient condition for black-hole formation in spherical gravitational collapse

    Energy Technology Data Exchange (ETDEWEB)

    Giambo, Roberto [Dipartimento di Matematica e Fisica, Universita di Camerino (Italy); Giannoni, Fabio [Dipartimento di Matematica e Fisica, Universita di Camerino (Italy); Magli, Giulio [Dipartimento di Matematica, Politecnico di Milano (Italy)

    2002-01-21

    A sufficient condition for the validity of cosmic censorship in spherical gravitational collapse is formulated and proved. The condition relies on an attractive mathematical property of the apparent horizon, which holds if 'minimal' requirements of physical reasonableness are satisfied by the matter model. (letter to the editor)

  4. Operation of CANDU power reactor in thorium self-sufficient fuel cycle

    Indian Academy of Sciences (India)

    This paper presents the results of calculations for CANDU reactor operation in thorium fuel cycle. Calculations are performed to estimate the feasibility of operation of heavy-water thermal neutron power reactor in self-sufficient thorium cycle. Parameters of active core and scheme of fuel reloading were considered to be the ...

  5. Lead–acid batteries coupled with photovoltaics for increased electricity self-sufficiency in households

    International Nuclear Information System (INIS)

    Oliveira e Silva de, Guilherme; Hendrick, Patrick

    2016-01-01

    Highlights: • Grid parity is reached for PV installations up to nearly 40% self-sufficiency. • Reaching beyond 40% self-sufficiency requires storage and support policies. • Peak consumption remains constant but load variability rises with self-sufficiency. • Changes in power plants portfolio and wholesale electricity prices are expected. • Limiting feed-in power is a promising solution for reducing load variability. - Abstract: With distributed generation of electricity growing in importance (especially with photovoltaics) and buildings being one of the main consumers of energy in modern societies, distributed storage of energy in buildings is expected to become increasingly present. This paper analyses the use of residential lead–acid energy storage coupled with photovoltaics and its possible interaction with the grid for different limits of feed-in power without any support policies. In the literature, these subjects are often treated independently and for very specific, non-optimised cases, thus motivating further research. Results show that reaching self-sufficiency values up to 40% is possible, close to grid parity values, and only with photovoltaics. Beyond 40%, energy storage must be used, strongly raising the cost of the electricity consumed and therefore the need for support policies for widespread adoption. Also, peak power consumption from the grid remains constant and load variability rises, suggesting that an increase in self-sufficiency would be accompanied by lower utilisation factors of power plants and, consequently, higher wholesale electricity prices during no sunshine hours. Limiting feed-in power attenuates the increased load variability and only slightly affects the economic viability of such installations. These results present a novel optimisation tool for developers and should be considered in future studies of distributed photovoltaics and energy storage as well as in energy policy.

  6. Consequences of "Minimal" Group Affiliations in Children

    Science.gov (United States)

    Dunham, Yarrow; Baron, Andrew Scott; Carey, Susan

    2011-01-01

    Three experiments (total N = 140) tested the hypothesis that 5-year-old children's membership in randomly assigned "minimal" groups would be sufficient to induce intergroup bias. Children were randomly assigned to groups and engaged in tasks involving judgments of unfamiliar in-group or out-group children. Despite an absence of information…

  7. Increased conjugated bilirubin is sufficient to initiate screening for biliary atresia

    DEFF Research Database (Denmark)

    Madsen, Stine Skipper; Kvist, Nina; Thorup, Jørgen

    2015-01-01

    INTRODUCTION: Biliary atresia is the leading cause of liver transplantation in children. It affects 1:15,000 in Denmark. With a national birth rate of 60,000, four children are born every year with biliary atresia. Early correction of biliary obstruction is essential to prevent fatal biliary...... cirrhosis. The Danish Health and Medicines Authority (DHMA) demands diagnostic evaluation of children with elevated level of serum bilirubin after two weeks of age. Biliary atresia has to be excluded if conjugated bilirubin level is above than 20 μmol/l, and/or more than 20% of total bilirubin...

  8. Internal urethrotomy for recurrence after perineal anastomotic urethroplasty for posttraumatic pediatric posterior urethral stricture: could it be sufficient?

    Science.gov (United States)

    Helmy, Tamer E; Hafez, Ashraf T

    2013-06-01

    To evaluate the long-term outcome of visual internal urethrotomy (VIU) after perineal anastomotic urethroplasty for posttraumatic pediatric posterior urethral strictures. Data of 22 boys who had undergone internal urethrotomy for recurrent stricture after perineal anastomotic urethroplasty for posttraumatic posterior urethral strictures between 1998 and 2008 were analyzed retrospectively regarding patient age, interval between anastomotic urethroplasty and internal urethrotomy, stricture length, surgical technique, and postoperative complications. VIU was performed in patients in whom a guidewire could be passed beyond the stricture segment. The eventual surgical success was defined as asymptomatic voiding without clinical evidence of residual stricture (good flow rate and absence of residual urine). The mean (range) age of patients was 12.2 (3-17) years. All patients had a road traffic accident with associated pelvic fracture. The perineal approach for anastomotic urethroplasty was adopted in all. The estimated stricture length was 0.5 cm or less in 15 patients and was 0.5 to 1 cm in 7 patients. The interval between anastomotic urethroplasty and internal urethrotomy was early-after 12 weeks or less-in 13 children or late-beyond 12 weeks-in the remaining 9. The overall mean interval was 18 (5-63) weeks. In all patients, a guidewire could be passed through the strictured area. One VIU was performed in 17 patients, 2 VIU in 3 patients, while 3 VIU were performed in 2 patients. There was no extravasation reported. The mean follow-up duration was 98 (38-210) months. VIU was successful in 20 of 22 (90%) patients. All patients voided with no symptoms and were continent. VIU offers high success rate and can be sufficient in recurrent strictures of less than 1 cm length after anastomotic urethroplasty in children whenever a guidewire can be passed through the stricture area.

  9. Is a single dose of meningococcal serogroup C conjugate vaccine sufficient for protection? experience from the Netherlands

    Directory of Open Access Journals (Sweden)

    Kaaijk Patricia

    2012-02-01

    Full Text Available Abstract Background The first meningococcal serogroup C (MenC conjugate vaccine was licensed in 1999 and introduced in the United Kingdom. Countries that have implemented the MenC vaccine since then in their national immunisation programmes use different schedules. Nevertheless, all involved countries seem to experience substantial declines in the incidence of MenC disease. Discussion Since 2001, the MenC conjugate vaccine has been implemented in the Netherlands by offering a single dose to all children aged 14 months. Prior to the introduction of the vaccine into the national immunisation programme, a catch-up vaccination campaign was initiated in which a single dose of the MenC conjugate vaccine was offered to all children aged from 14 months up to and including 18 years. Since then, there has been no report of any case of MenC disease among immunocompetent vaccinees. Administration of a single dose of MenC conjugate vaccine after infancy could be beneficial considering the already complex immunisation schedules with large numbers of vaccinations in the first year of life. The present paper deals with the advantages and critical aspects of a single dose of the MenC conjugate vaccine. Summary A single dose of MenC conjugate vaccine at the age of 14 months in combination with a catch up vaccine campaign appeared to be a successful strategy to prevent MenC disease in the Netherlands, thereby confirming that a single dose of the vaccine could sufficiently protect against disease. Nevertheless, this approach can only be justified in countries with a relatively low incidence of serogroup C meningococcal disease in the first year of life. Furthermore, a good surveillance programme is recommended for timely detection of vaccine breakthroughs and outbreaks among non-vaccinees, since long-term protection after a single dose in the second year of life cannot currently be guaranteed.

  10. Parental perspectives of children using cochlear implant.

    Science.gov (United States)

    Stefanini, Marcela Roselin; Morettin, Marina; Zabeu, Julia Speranza; Bevilacqua, Maria Cecília; Moret, Adriane Lima Mortari

    2014-01-01

    To evaluate the parents' perspective with regard to evolution of their child with cochlear implant (CI). This was a cross-sectional prospective study conducted at the Centro de Pesquisas Audiológicas of Hospital de Reabilitação de Anomalias Craniofaciais of Universidade de São Paulo. The selection of the sample was performed from the spontaneous demand, among the months from July to December 2011. The final sample comprised 50 parents or guardians of children using CI, with minimum 1 year and maximum of 3 years of device use. The translated and adapted to Brazilian Portuguese version of the questionnaire "Perspectives of parents of children with cochlear implants" was applied. This instrument consists of 74 questions and allows quantification of the parents' perspective on subscales that illustrate the situation of the child and family. Each question has five options scored from one to five responses. The Spearman test for comparison of results between the subscales was applied. The social relationships, self-sufficiency, and communication subscales showed the highest mean score, whereas the worst score was for child support subscale, reflecting the independence and autonomy of the patients. The correlation between the child subscales was realized, and the results showed themselves significant and positive for communication subscale of communication with all others subscales. The family subscales also had a positive correlation with the communication, education, and self-sufficiency. These results demonstrate that parents have good expectations regarding communication, independence, and social participation of children after CI surgery, and this questionnaire is a useful tool for use in clinical practice.

  11. The necessary and sufficient conditions of therapeutic personality change: Reactions to Rogers' 1957 article.

    Science.gov (United States)

    Samstag, Lisa Wallner

    2007-09-01

    Carl Rogers' article (see record 2007-14639-002) on the necessary and sufficient conditions for personality change has had a significant impact on the field of psychotherapy and psychotherapy research. He emphasized the client as arbiter of his or her own subjective experience and tested his hypothesized therapist-offered conditions of change using recorded sessions. This aided in demystifying the therapeutic process and led to a radical shift in the listening stance of the therapist. I briefly outline my views regarding the influence of the ideas presented in this work, describe the intellectual and cultural context of the times, and discuss a number of ways in which the therapist-offered conditions for psychological transformation are neither necessary nor sufficient. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

  12. A Sufficient Condition on Convex Relaxation of AC Optimal Power Flow in Distribution Networks

    DEFF Research Database (Denmark)

    Huang, Shaojun; Wu, Qiuwei; Wang, Jianhui

    2016-01-01

    This paper proposes a sufficient condition for the convex relaxation of AC Optimal Power Flow (OPF) in radial distribution networks as a second order cone program (SOCP) to be exact. The condition requires that the allowed reverse power flow is only reactive or active, or none. Under the proposed...... solution of the SOCP can be converted to an optimal solution of the original AC OPF. The efficacy of the convex relaxation to solve the AC OPF is demonstrated by case studies of an optimal multi-period planning problem of electric vehicles (EVs) in distribution networks....... sufficient condition, the feasible sub-injection region (power injections of nodes excluding the root node) of the AC OPF is convex. The exactness of the convex relaxation under the proposed condition is proved through constructing a group of monotonic series with limits, which ensures that the optimal...

  13. CaFe2O4 as a self-sufficient solar energy converter

    Science.gov (United States)

    Tablero, C.

    2017-10-01

    An ideal solar energy to electricity or fuel converter should work without the use of any external bias potential. An analysis of self-sufficiency when CaFe2O4 is used to absorb the sunlight is carried out based on the CaFe2O4 absorption coefficient. We started to obtain this coefficient theoretically within the experimental bandgap range in order to fix the interval of possible values of photocurrents, maximum absorption efficiencies, and photovoltages and thus that of self-sufficiency considering only the radiative processes. Also for single-gap CaFe2O4, we evaluate an alternative for increasing the photocurrent and maximum absorption efficiency based on inserting an intermediate band using high doping or alloying.

  14. Comparison of methods for calculating conditional expectations of sufficient statistics for continuous time Markov chains

    DEFF Research Database (Denmark)

    Tataru, Paula Cristina; Hobolth, Asger

    2011-01-01

    past evolutionary events (exact times and types of changes) are unaccessible and the past must be inferred from DNA sequence data observed in the present. RESULTS: We describe and implement three algorithms for computing linear combinations of expected values of the sufficient statistics, conditioned......BACKGROUND: Continuous time Markov chains (CTMCs) is a widely used model for describing the evolution of DNA sequences on the nucleotide, amino acid or codon level. The sufficient statistics for CTMCs are the time spent in a state and the number of changes between any two states. In applications...... of the algorithms is available at www.birc.au.dk/~paula/. CONCLUSIONS: We use two different models to analyze the accuracy and eight experiments to investigate the speed of the three algorithms. We find that they have similar accuracy and that EXPM is the slowest method. Furthermore we find that UNI is usually...

  15. The degree of C0-sufficiency of analytic function germs with respect to an ideal

    International Nuclear Information System (INIS)

    Pham Tien Son

    2006-07-01

    Let f:(C 2 , 0) → (C, 0) be an analytic function germ of two complex variables and let I be an ideal of C{x,y). We give some formulae for the degree of C 0 -sufficiency of f with respect to I. When I is the maximal ideal we retrieve a result of T.C. Kuo and Y.C. Lu. (author)

  16. Maximizing Health or Sufficient Capability in Economic Evaluation? A Methodological Experiment of Treatment for Drug Addiction.

    Science.gov (United States)

    Goranitis, Ilias; Coast, Joanna; Day, Ed; Copello, Alex; Freemantle, Nick; Frew, Emma

    2017-07-01

    Conventional practice within the United Kingdom and beyond is to conduct economic evaluations with "health" as evaluative space and "health maximization" as the decision-making rule. However, there is increasing recognition that this evaluative framework may not always be appropriate, and this is particularly the case within public health and social care contexts. This article presents a methodological case study designed to explore the impact of changing the evaluative space within an economic evaluation from health to capability well-being and the decision-making rule from health maximization to the maximization of sufficient capability. Capability well-being is an evaluative space grounded on Amartya Sen's capability approach and assesses well-being based on individuals' ability to do and be the things they value in life. Sufficient capability is an egalitarian approach to decision making that aims to ensure everyone in society achieves a normatively sufficient level of capability well-being. The case study is treatment for drug addiction, and the cost-effectiveness of 2 psychological interventions relative to usual care is assessed using data from a pilot trial. Analyses are undertaken from a health care and a government perspective. For the purpose of the study, quality-adjusted life years (measured using the EQ-5D-5L) and years of full capability equivalent and years of sufficient capability equivalent (both measured using the ICECAP-A [ICEpop CAPability measure for Adults]) are estimated. The study concludes that different evaluative spaces and decision-making rules have the potential to offer opposing treatment recommendations. The implications for policy makers are discussed.

  17. On necessary and sufficient conditions for some Higgs potentials to be bounded from below

    International Nuclear Information System (INIS)

    Klimenko, K.G.

    1984-01-01

    The necessary and sufficient (NS) conditions have been obtained to make the Higgs potentials be bounded from below. Here these potentials are constructed from: (i) two doublets, as well as two doublets and a singlet of SU(2)-group; (ii) adjoint and vector representations of SO(n). For the potential constructed from the adjoint and fundamental SU(n) multiplets, the problem of NS conditions is solved partially

  18. Retrocausal Effects as a Consequence of Quantum Mechanics Refined to Accommodate the Principle of Sufficient Reason

    Energy Technology Data Exchange (ETDEWEB)

    Stapp, Henry P.

    2011-05-10

    The principle of sufficient reason asserts that anything that happens does so for a reason: no definite state of affairs can come into being unless there is a sufficient reason why that particular thing should happen. This principle is usually attributed to Leibniz, although the first recorded Western philosopher to use it was Anaximander of Miletus. The demand that nature be rational, in the sense that it be compatible with the principle of sufficient reason, conflicts with a basic feature of contemporary orthodox physical theory, namely the notion that nature's response to the probing action of an observer is determined by pure chance, and hence on the basis of absolutely no reason at all. This appeal to pure chance can be deemed to have no rational fundamental place in reason-based Western science. It is argued here, on the basis of the other basic principles of quantum physics, that in a world that conforms to the principle of sufficient reason, the usual quantum statistical rules will naturally emerge at the pragmatic level, in cases where the reason behind nature's choice of response is unknown, but that the usual statistics can become biased in an empirically manifest way when the reason for the choice is empirically identifiable. It is shown here that if the statistical laws of quantum mechanics were to be biased in this way then the basically forward-in-time unfolding of empirical reality described by orthodox quantum mechanics would generate the appearances of backward-time-effects of the kind that have been reported in the scientific literature.

  19. Sufficient condition for generation of multiple solidification front in one-dimensional solidification of binary alloys

    International Nuclear Information System (INIS)

    Bobula, E.; Kalicka, Z.

    1981-10-01

    In the paper we consider the one-dimensional solidification of binary alloys in the finite system. The authors present the sufficient condition for solidification in the liquid in front of the moving solid-liquid interface. The effect may produce a fluctuating concentration distributin in the solid. The convection in the liquid and supercooling required for homogeneous nucleation are omitted. A local-equilibrium approximation at the liquid-solid interface is supposed. (author)

  20. Can New Zealand achieve self-sufficiency in its nursing workforce?

    Science.gov (United States)

    North, Nicola

    2011-01-01

    This paper reviews impacts on the nursing workforce of health policy and reforms of the past two decades and suggests reasons for both current difficulties in retaining nurses in the workforce and measures to achieve short-term improvements. Difficulties in retaining nurses in the New Zealand workforce have contributed to nursing shortages, leading to a dependence on overseas recruitment. In a context of global shortages and having to compete in a global nursing labour market, an alternative to dependence on overseas nurses is self-sufficiency. Discursive paper. Analysis of nursing workforce data highlighted threats to self-sufficiency, including age structure, high rates of emigration of New Zealand nurses with reliance on overseas nurses and an annual output of nurses that is insufficient to replace both expected retiring nurses and emigrating nurses. A review of recent policy and other documents indicates that two decades of health reform and lack of a strategic focus on nursing has contributed to shortages. Recent strategic approaches to the nursing workforce have included workforce stocktakes, integrated health workforce development and nursing workforce projections, with a single authority now responsible for planning, education, training and development for all health professions and sectors. Current health and nursing workforce development strategies offer wide-ranging and ambitious approaches. An alternative approach is advocated: based on workforce data analysis, pressing threats to self-sufficiency and measures available are identified to achieve, in the short term, the maximum impact on retaining nurses. A human resources in health approach is recommended that focuses on employment conditions and professional nursing as well as recruitment and retention strategies. Nursing is identified as 'crucial' to meeting demands for health care. A shortage of nurses threatens delivery of health services and supports the case for self-sufficiency in the nursing

  1. Economic efficiency or self-sufficiency: alternative strategies for oil consumers?

    International Nuclear Information System (INIS)

    Heal, D.W.

    1992-01-01

    The ideal energy source is low cost (efficient) and reliable (secure). The high price and perceived political unreliability of Middle East oil supplies prompted a nearly worldwide trend towards energy self-sufficiency. Gains in energy efficiency, which have been most marked in the OECD, are permanent and, prompted by environmental concern, probably progressive. But the opportunity that is still available to low cost oil suppliers to regain lost markets will only be realized if those supplies are demonstrably reliable. (author)

  2. A sufficiency property arising from the characterization of extremes of Markov chains

    OpenAIRE

    Bortot, Paola; Coles, Stuart

    2000-01-01

    At extreme levels, it is known that for a particular choice of marginal distribution, transitions of a Markov chain behave like a random walk. For a broad class of Markov chains, we give a characterization for the step length density of the limiting random walk, which leads to an interesting sufficiency property. This representation also leads us to propose a new technique for kernel density estimation for this class of models.

  3. Retrocausal Effects as a Consequence of Quantum Mechanics Refined to Accommodate the Principle of Sufficient Reason

    International Nuclear Information System (INIS)

    Stapp, Henry P.

    2011-01-01

    The principle of sufficient reason asserts that anything that happens does so for a reason: no definite state of affairs can come into being unless there is a sufficient reason why that particular thing should happen. This principle is usually attributed to Leibniz, although the first recorded Western philosopher to use it was Anaximander of Miletus. The demand that nature be rational, in the sense that it be compatible with the principle of sufficient reason, conflicts with a basic feature of contemporary orthodox physical theory, namely the notion that nature's response to the probing action of an observer is determined by pure chance, and hence on the basis of absolutely no reason at all. This appeal to pure chance can be deemed to have no rational fundamental place in reason-based Western science. It is argued here, on the basis of the other basic principles of quantum physics, that in a world that conforms to the principle of sufficient reason, the usual quantum statistical rules will naturally emerge at the pragmatic level, in cases where the reason behind nature's choice of response is unknown, but that the usual statistics can become biased in an empirically manifest way when the reason for the choice is empirically identifiable. It is shown here that if the statistical laws of quantum mechanics were to be biased in this way then the basically forward-in-time unfolding of empirical reality described by orthodox quantum mechanics would generate the appearances of backward-time-effects of the kind that have been reported in the scientific literature.

  4. Journal of applied mathematics

    National Research Council Canada - National Science Library

    2001-01-01

    "[The] Journal of Applied Mathematics is a refereed journal devoted to the publication of original research papers and review articles in all areas of applied, computational, and industrial mathematics...

  5. Mesothelioma Applied Research Foundation

    Science.gov (United States)

    ... Foundation Experts Can Answer Your Questions! The Mesothelioma Applied Research Foundation's team of experts is available to answer ... a law firm. Read more about the Mesothelioma Applied Research Foundation . TO GET HELP CALL: (877) End-Meso ...

  6. MSEBAG: a dynamic classifier ensemble generation based on `minimum-sufficient ensemble' and bagging

    Science.gov (United States)

    Chen, Lei; Kamel, Mohamed S.

    2016-01-01

    In this paper, we propose a dynamic classifier system, MSEBAG, which is characterised by searching for the 'minimum-sufficient ensemble' and bagging at the ensemble level. It adopts an 'over-generation and selection' strategy and aims to achieve a good bias-variance trade-off. In the training phase, MSEBAG first searches for the 'minimum-sufficient ensemble', which maximises the in-sample fitness with the minimal number of base classifiers. Then, starting from the 'minimum-sufficient ensemble', a backward stepwise algorithm is employed to generate a collection of ensembles. The objective is to create a collection of ensembles with a descending fitness on the data, as well as a descending complexity in the structure. MSEBAG dynamically selects the ensembles from the collection for the decision aggregation. The extended adaptive aggregation (EAA) approach, a bagging-style algorithm performed at the ensemble level, is employed for this task. EAA searches for the competent ensembles using a score function, which takes into consideration both the in-sample fitness and the confidence of the statistical inference, and averages the decisions of the selected ensembles to label the test pattern. The experimental results show that the proposed MSEBAG outperforms the benchmarks on average.

  7. The feasibility and challenges of energy self-sufficient wastewater treatment plants

    International Nuclear Information System (INIS)

    Gu, Yifan; Li, Yue; Li, Xuyao; Luo, Pengzhou; Wang, Hongtao; Robinson, Zoe P.; Wang, Xin; Wu, Jiang; Li, Fengting

    2017-01-01

    Highlights: •Various influencing factors of energy use in WWTPs are characterized. •Benchmark energy consumption in WWTPs in different countries are highlighted. •Energy recovery or saving technologies in WWTPs are summarized. •Recent advances in optimization of energy recovery technologies are highlighted. •Feasibility and challenges of energy self-sufficient WWTPs are explored. -- Abstract: Energy efficiency optimization is crucial for wastewater treatment plants (WWTPs) because of increasing energy costs and concerns about global climate change. Energy efficiency optimization can be achieved through a combination of energy recovery from the wastewater treatment process and energy saving-related technologies. Through these two approaches energy self-sufficiency of WWTPs is achievable, and research is underway to reduce operation costs and energy consumption and to achieve carbon neutrality. In this paper, we analyze energy consumption and recovery in WWTPs and characterize the factors that influence energy use in WWTPs, including treatment techniques, treatment capacities, and regional differences. Recent advances in the optimization of energy recovery technologies and theoretical analysis models for the analysis of different technological solutions are presented. Despite some challenges in implementation, such as technological barriers and high investment costs, particularly in developing countries, this paper highlights the potential for more energy self-sufficient WWTPs to be established in the future.

  8. Staple Food Self-Sufficiency of Farmers Household Level in The Great Solo

    Science.gov (United States)

    Darsono

    2017-04-01

    Analysis of food security level of household is a novelty of measurement standards which usually includes regional and national levels. With household approach is expected to provide the basis of sharp food policy formulation. The purpose of this study are to identify the condition of self-sufficiency in staple foods, and to find the main factors affecting the dynamics of self-sufficiency in staple foods on farm household level in Great Solo. Using primary data from 50 farmers in the sample and secondary data in Great Solo (Surakarta city, Boyolali, Sukoharjo, Karanganyar, Wonogiri, Sragen and Klaten). Compiled panel data were analyzed with linear probability regression models to produce a good model. The results showed that farm households in Great Solo has a surplus of staple food (rice) with an average consumption rate of 96.8 kg/capita/year. This number is lower than the national rate of 136.7 kg/capita/year. The main factors affecting the level of food self-sufficiency in the farmer household level are: rice production, rice consumption, land tenure, and number of family members. Key recommendations from this study are; improvement scale of the land cultivation for rice farming and non-rice diversification consumption.

  9. High spatial validity is not sufficient to elicit voluntary shifts of attention.

    Science.gov (United States)

    Pauszek, Joseph R; Gibson, Bradley S

    2016-10-01

    Previous research suggests that the use of valid symbolic cues is sufficient to elicit voluntary shifts of attention. The present study interpreted this previous research within a broader theoretical context which contends that observers will voluntarily use symbolic cues to orient their attention in space when the temporal costs of using the cues are perceived to be less than the temporal costs of searching without the aid of the cues. In this view, previous research has not addressed the sufficiency of valid symbolic cues, because the temporal cost of using the cues is usually incurred before the target display appears. To address this concern, 70%-valid spatial word cues were presented simultaneously with a search display. In addition, other research suggests that opposing cue-dependent and cue-independent spatial biases may operate in these studies and alter standard measures of orienting. After identifying and controlling these opposing spatial biases, the results of two experiments showed that the word cues did not elicit voluntary shifts of attention when the search task was relatively easy but did when the search task was relatively difficult. Moreover, the findings also showed that voluntary use of the word cues changed over the course of the experiment when the task was difficult, presumably because the temporal cost of searching without the cue lessened as the task got easier with practice. Altogether, the present findings suggested that the factors underlying voluntary control are multifaceted and contextual, and that spatial validity alone is not sufficient to elicit voluntary shifts of attention.

  10. Navigating behavioral energy sufficiency. Results from a survey in Swiss cities on potential behavior change.

    Science.gov (United States)

    Seidl, Roman; Moser, Corinne; Blumer, Yann

    2017-01-01

    Many countries have some kind of energy-system transformation either planned or ongoing for various reasons, such as to curb carbon emissions or to compensate for the phasing out of nuclear energy. One important component of these transformations is the overall reduction in energy demand. It is generally acknowledged that the domestic sector represents a large share of total energy consumption in many countries. Increased energy efficiency is one factor that reduces energy demand, but behavioral approaches (known as "sufficiency") and their respective interventions also play important roles. In this paper, we address citizens' heterogeneity regarding both their current behaviors and their willingness to realize their sufficiency potentials-that is, to reduce their energy consumption through behavioral change. We collaborated with three Swiss cities for this study. A survey conducted in the three cities yielded thematic sets of energy-consumption behavior that various groups of participants rated differently. Using this data, we identified four groups of participants with different patterns of both current behaviors and sufficiency potentials. The paper discusses intervention types and addresses citizens' heterogeneity and behaviors from a city-based perspective.

  11. Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs.

    Science.gov (United States)

    Choi, Kyung-Suk; Lee, Chanmi; Harfe, Brian D

    2012-01-01

    The intervertebral discs, located between adjacent vertebrae, are required for stability of the spine and distributing mechanical load throughout the vertebral column. All cell types located in the middle regions of the discs, called nuclei pulposi, are derived from the embryonic notochord. Recently, it was shown that the hedgehog signaling pathway plays an essential role during formation of nuclei pulposi. However, during the time that nuclei pulposi are forming, Shh is expressed in both the notochord and the nearby floor plate. To determine the source of SHH protein sufficient for formation of nuclei pulposi we removed Shh from either the floor plate or the notochord using tamoxifen-inducible Cre alleles. Removal of Shh from the floor plate resulted in phenotypically normal intervertebral discs, indicating that Shh expression in this tissue is not required for disc patterning. In addition, embryos that lacked Shh in the floor plate had normal vertebral columns, demonstrating that Shh expression in the notochord is sufficient for pattering the entire vertebral column. Removal of Shh from the notochord resulted in the absence of Shh in the floor plate, loss of intervertebral discs and vertebral structures. These data indicate that Shh expression in the notochord is sufficient for patterning of the intervertebral discs and the vertebral column. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  12. Redox self-sufficient whole cell biotransformation for amination of alcohols.

    Science.gov (United States)

    Klatte, Stephanie; Wendisch, Volker F

    2014-10-15

    Whole cell biotransformation is an upcoming tool to replace common chemical routes for functionalization and modification of desired molecules. In the approach presented here the production of various non-natural (di)amines was realized using the designed whole cell biocatalyst Escherichia coli W3110/pTrc99A-ald-adh-ta with plasmid-borne overexpression of genes for an l-alanine dehydrogenase, an alcohol dehydrogenase and a transaminase. Cascading alcohol oxidation with l-alanine dependent transamination and l-alanine dehydrogenase allowed for redox self-sufficient conversion of alcohols to the corresponding amines. The supplementation of the corresponding (di)alcohol precursors as well as amino group donor l-alanine and ammonium chloride were sufficient for amination and redox cofactor recycling in a resting buffer system. The addition of the transaminase cofactor pyridoxal-phosphate and the alcohol dehydrogenase cofactor NAD(+) was not necessary to obtain complete conversion. Secondary and cyclic alcohols, for example, 2-hexanol and cyclohexanol were not aminated. However, efficient redox self-sufficient amination of aliphatic and aromatic (di)alcohols in vivo was achieved with 1-hexanol, 1,10-decanediol and benzylalcohol being aminated best. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. Refueling availability for alternative fuel vehicle markets: Sufficient urban station coverage

    International Nuclear Information System (INIS)

    Melaina, Marc; Bremson, Joel

    2008-01-01

    Alternative fuel vehicles can play an important role in addressing the challenges of climate change, energy security, urban air pollution and the continued growth in demand for transportation services. The successful commercialization of alternative fuels for vehicles is contingent upon a number of factors, including vehicle cost and performance. Among fuel infrastructure issues, adequate refueling availability is one of the most fundamental to successful commercialization. A commonly cited source reports 164,300 refueling stations in operation nationwide. However, from the perspective of refueling availability, this nationwide count tends to overstate the number of stations required to support the widespread deployment of alternative fuel vehicles. In terms of spatial distribution, the existing gasoline station networks in many urban areas are more than sufficient. We characterize a sufficient level of urban coverage based upon a subset of cities served by relatively low-density station networks, and estimate that some 51,000 urban stations would be required to provide this sufficient level of coverage to all major urban areas, 33 percent less than our estimate of total urban stations. This improved characterization will be useful for engineering, economic and policy analyses. (author)

  14. FOOD SELF-SUFFICIENCY OF THE EUROPEAN UNION COUNTRIES – ENERGETIC APPROACH

    Directory of Open Access Journals (Sweden)

    Arkadiusz Sadowski

    2016-06-01

    Full Text Available The paper covers the issues of a basic social need, namely alimentation. The aim of the research is to evaluate the energetic food self-sufficiency and its changes in the European Union countries. The research has been conducted using the author’s methodology basing on the amount of energy produced and consumed in 1990-2009. The analyses proved that within the considered period, the European Union became an importer of net energy comprised in agricultural products. The excess in produced energy was mainly observed by the countries of European lowland. Moreover in most of the countries, a decrease in the analyzed factor was observed when compared with the 1990-1999 period. On the other hand, in relation to the new member states the increase in food energetic self-sufficiency was observed. The conclusion has been drawn that, while the general food self-sufficiency is mainly determined by environmental factors, its dynamics is primarily influenced by the factors connected with agricultural policy.

  15. ANALYSIS OF SUFFICIENCY OF THE BEARING CAPACITY OF BUILDING STRUCTURES OF OPERATING SITES OF MAIN BUILDINGS OF THERMAL POWER PLANTS

    Directory of Open Access Journals (Sweden)

    Alekseeva Ekaterina Leonidovna

    2012-10-01

    Full Text Available Upon examination of eleven main buildings of power plants, analysis of defects and damages of building structures was performed. Thereafter, the damageability of principal bearing structures of main buildings of thermal plants was analyzed. It was identified that the fastest growing defects and damages were concentrated in the structures of operating sites. The research of the rate of development of the most frequent damages and defects made it possible to conclude that internal corrosion of the reinforcing steel was the most dangerous defect, as far as the reinforced concrete elements of operating sites were concerned. Methods of mathematical statistics were applied to identify the reinforcing steel development pattern inside reinforced concrete elements of floors of operating sites. It was identified that the probability of corrosion of reinforced concrete elements of operating sites was distributed in accordance with the demonstrative law. Based on these data, calculation of strength of reinforced concrete slabs and metal beams was performed in terms of their regular sections, given the natural loads and the realistic condition of structures. As a result, dependence between the bearing capacity reserve ratio and the corrosion development pattern was identified for reinforced concrete slabs and metal beams of operating sites. In order to analyze the sufficiency of the bearing capacity of building structures of operating sites in relation to their time in commission, equations were derived to identify the nature of dependence between the sufficiency of the bearing capacity of reinforced concrete slabs and metal beams of the operating sites and their time in commission.

  16. Applied Energy Program

    Science.gov (United States)

    Science Programs Applied Energy Programs Civilian Nuclear Energy Programs Laboratory Directed Research » Applied Energy Program Applied Energy Program Los Alamos is using its world-class scientific capabilities to enhance national energy security by developing energy sources with limited environmental impact

  17. Applied functional analysis

    CERN Document Server

    Griffel, DH

    2002-01-01

    A stimulating introductory text, this volume examines many important applications of functional analysis to mechanics, fluid mechanics, diffusive growth, and approximation. Detailed enough to impart a thorough understanding, the text is also sufficiently straightforward for those unfamiliar with abstract analysis. Its four-part treatment begins with distribution theory and discussions of Green's functions. Essentially independent of the preceding material, the second and third parts deal with Banach spaces, Hilbert space, spectral theory, and variational techniques. The final part outlines the

  18. Shaping children's healthy eating habits with food placements? Food placements of high and low nutritional value in cartoons, Children's BMI, food-related parental mediation strategies, and food choice

    NARCIS (Netherlands)

    Naderer, B.; Matthes, J.; Binder, A.; Marquart, F.; Mayrhofer, M.; Obereder, A.; Spielvogel, I.

    Research on media induced food choices of children has not sufficiently investigated whether food placements of snacks high in nutritional value can strengthen children's healthy eating behavior. Furthermore, we lack knowledge about the moderating role of children's individual characteristics such

  19. Torture in children.

    Science.gov (United States)

    Quiroga, Jose

    2009-01-01

    This is a review article that studies the problem of torture in children. Torture in children is a significant worldwide problem, but there are no official or reliable independent statistics to measure the magnitude of the problem. The definition of torture in the Convention against Torture and Other Cruel, Inhuman or Degrading Treatment or Punishment applies to adults and children. The Convention on the Rights of the Child defines children as "every human being below the age of eighteen years". Torture in children happens during peace times and during political violence and war conflicts. The majority of torture victims happen during peace times. The high-risk groups are impoverished children living in the street, children deprived of parental care, children in conflict with the law, and children in detention. During political violence and war the high risk children are the children detained during political violence, child soldiers, children internally displaced in refugee camps, detained children during the war against terrorism and children tortured by peacekeeping forces. The perpetrators of torture in children are the members of the same forces that torture adults, generally the police, civil police, security guards trained by police, prison guards, and military forces. The paper identifies some preventive measure and develops recommendations for action at the local, national and international level.

  20. Evaluation of muscle activity, bite force and salivary cortisol in children with bruxism before and after low level laser applied to acupoints: study protocol for a randomised controlled trial.

    Science.gov (United States)

    Salgueiro, Mônica da Consolação Canuto; Bortoletto, Carolina Carvalho; Horliana, Anna Carolina RattoTempestini; Mota, Ana Carolina Costa; Motta, Lara Jansiski; Motta, Pamella de Barros; MesquitaFerrari, Raquel Agnelli; Fernandes, Kristianne Porta Santos; Bussadori, Sandra Kalil

    2017-08-08

    Bruxism is a repetitive activity that causes tooth wear, audible sounds, and discomfort. Preventive measures have been studied for conditions that can exert a negative influence on physiological development in children. Low-level laser therapy administered over acupoints is an effective, painless, low-cost treatment option that has achieved good results. Thus, the aim of the proposed study is to evaluate changes in muscle activity, bite force and salivary cortisol in children with bruxism after the application of low-level laser to accupoints. The children will be randomly allocated to four groups of 19 individuals: G1 - low-level laser; G2 - occlusal splint; G3 - placebo laser; and G4 - control (without bruxism). The BTS TMJOINT electromyography will be used to determine muscle activity and a digital gnathodynamometer will be used to measure bite force. Salivary cortisol will be analysed at baseline as well as one and six months after treatment. Two-way ANOVA will be employed and complemented by Tukey's test. Bruxism is a repetitive activity of the masticatory muscles that can have negative consequences if not treated, such as tooth wear, noises, discomfort and anxiety. Thus, control and treatment measures should be taken. Although low-level laser therapy over acupoints has been indicated for children, the effects of this treatment modality have not yet been studied. NCT02757261 on 8 April 2016. This study protocol received a grant from the Brazilian fostering agency São Paulo Research Foundation (FAPESP: #2015/24731-0).

  1. The Implications of the Collaboration among Parents, Teachers, and Psychologists, Parenting Education Provided by Schools, and Applied Behavior Analysis in the Lives of Children Diagnosed with Autism Spectrum Disorder

    Science.gov (United States)

    Udaze, Joanne

    2016-01-01

    There was a need for an increased and equal partnership between school professionals and parents. Collaboration will help parents and school professionals to understand one another. Natural environment teaching and routine should be incorporated into the intervention strategies that address the needs of the children diagnosed with autism. When…

  2. A simple, sufficient, and consistent method to score the status of threats and demography of imperiled species

    Directory of Open Access Journals (Sweden)

    Jacob W. Malcom

    2016-07-01

    Full Text Available Managers of large, complex wildlife conservation programs need information on the conservation status of each of many species to help strategically allocate limited resources. Oversimplifying status data, however, runs the risk of missing information essential to strategic allocation. Conservation status consists of two components, the status of threats a species faces and the species’ demographic status. Neither component alone is sufficient to characterize conservation status. Here we present a simple key for scoring threat and demographic changes for species using detailed information provided in free-form textual descriptions of conservation status. This key is easy to use (simple, captures the two components of conservation status without the cost of more detailed measures (sufficient, and can be applied by different personnel to any taxon (consistent. To evaluate the key’s utility, we performed two analyses. First, we scored the threat and demographic status of 37 species recently recommended for reclassification under the Endangered Species Act (ESA and 15 control species, then compared our scores to two metrics used for decision-making and reports to Congress. Second, we scored the threat and demographic status of all non-plant ESA-listed species from Florida (54 spp., and evaluated scoring repeatability for a subset of those. While the metrics reported by the U.S. Fish and Wildlife Service (FWS are often consistent with our scores in the first analysis, the results highlight two problems with the oversimplified metrics. First, we show that both metrics can mask underlying demographic declines or threat increases; for example, ∼40% of species not recommended for reclassification had changes in threats or demography. Second, we show that neither metric is consistent with either threats or demography alone, but conflates the two. The second analysis illustrates how the scoring key can be applied to a substantial set of species to

  3. Is Transducer Hygiene sufficient when Vaginal Probes are used in the Clinical Routine?

    Science.gov (United States)

    Merz, E

    2016-04-01

    Vaginal ultrasound probes are semi-critical Group A medical products which must be disinfected following the manufacturer's instructions after every patient examination. According to the "Essential Requirements for Medical Devices (Directive 93/42/EEC, Annex I, paragraph 13)" the manufacturer's instructions for use for reusable products must contain suitable instructions for preparation processes. This presumes both an effective and material-compatible method. Evidence of effectiveness must be validated.In the Editorial in issue 1 Ultraschall in der Medizin/European Journal of Ultrasound 2005 we discussed the topic of transducer hygiene and stated that proper handling and cleaning as well as disinfection of probes in daily use are indispensable. This applies particularly to vaginal ultrasound probes routinely used in gynecological and obstetrical clinics, gynecological practices as well as IVF centers Normally the probe used in a transvaginal ultrasound examination is covered with a latex protective cover (with CE marking) which contains a certain amount of ultrasound gel. After the examination, the cover is removed and disposed of, and the gel is removed from the transducer. Since handling of the probe, ultrasound gel and cover can result in smear infections and cross-contamination with various pathogens (e. g. MRSA, HBV, HCV, HIV, herpes papilloma and cytomegalic viruses), after the protective cover is removed, the probe must be cleaned and subjected to disinfection with a bactericidal, fungicidal and virucidal effect. This is especially important in the event the cover ruptures during the vaginal examination, and the probe comes into direct contact with vaginal secretions or blood. The same likewise applies if the sterile protective cover is perforated during a follicular puncture. Usually special bactericidal, levurocidal and virucidal wipes or special submersion disinfection methods are available for disinfecting the vaginal ultrasound probes 11. Using

  4. Is there sufficient evidence regarding signage-based stair use interventions? A sequential meta-analysis.

    Science.gov (United States)

    Bauman, Adrian; Milton, Karen; Kariuki, Maina; Fedel, Karla; Lewicka, Mary

    2017-11-28

    The proliferation of studies using motivational signs to promote stair use continues unabated, with their oft-cited potential for increasing population-level physical activity participation. This study examined all stair use promotional signage studies since 1980, calculating pre-estimates and post-estimates of stair use. The aim of this project was to conduct a sequential meta-analysis to pool intervention effects, in order to determine when the evidence base was sufficient for population-wide dissemination. Using comparable data from 50 stair-promoting studies (57 unique estimates) we pooled data to assess the effect sizes of such interventions. At baseline, median stair usage across interventions was 8.1%, with an absolute median increase of 2.2% in stair use following signage-based interventions. The overall pooled OR indicated that participants were 52% more likely to use stairs after exposure to promotional signs (adjusted OR 1.52, 95% CI 1.37 to 1.70). Incremental (sequential) meta-analyses using z-score methods identified that sufficient evidence for stair use interventions has existed since 2006, with recent studies providing no further evidence on the effect sizes of such interventions. This analysis has important policy and practice implications. Researchers continue to publish stair use interventions without connection to policymakers' needs, and few stair use interventions are implemented at a population level. Researchers should move away from repeating short-term, small-scale, stair sign interventions, to investigating their scalability, adoption and fidelity. Only such research translation efforts will provide sufficient evidence of external validity to inform their scaling up to influence population physical activity. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  5. Virtual water and water self-sufficiency in agricultural and livestock products in Brazil.

    Science.gov (United States)

    da Silva, Vicente de Paulo R; de Oliveira, Sonaly D; Braga, Célia C; Brito, José Ivaldo B; de Sousa, Francisco de Assis S; de Holanda, Romildo M; Campos, João Hugo B C; de Souza, Enio P; Braga, Armando César R; Rodrigues Almeida, Rafaela S; de Araújo, Lincoln E

    2016-12-15

    Virtual water trade is often considered a solution for restricted water availability in many regions of the world. Brazil is the world leader in the production and export of various agricultural and livestock products. The country is either a strong net importer or a strong net exporter of these products. The objective of this study is to determine the volume of virtual water contained in agricultural and livestock products imported/exported by Brazil from 1997 to 2012, and to define the water self-sufficiency index of agricultural and livestock products in Brazil. The indexes of water scarcity (WSI), water dependency (WDI) and water self-sufficiency (WSSI) were calculated for each Brazilian state. These indexes and the virtual water balance were calculated following the methodology developed by Chapagain and Hoekstra (2008) and Hoekstra and Hung (2005). The total water exports and imports embedded in agricultural and livestock products were 5.28 × 10 10 and 1.22 × 10 10  Gm 3  yr -1 , respectively, which results in positive virtual water balance of 4.05 × 10 10  Gm 3  yr -1 . Brazil is either a strong net importer or a strong net exporter of agricultural and livestock products among the Mercosur countries. Brazil has a positive virtual water balance of 1.85 × 10 10  Gm 3  yr -1 . The indexes used in this study reveal that Brazil is self-sufficient in food production, except for a few products such as wheat and rice. Horticultural products (tomato, onion, potato, cassava and garlic) make up a unique product group with negative virtual water balance in Brazil. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Optimization of stand-alone photovoltaic systems with hydrogen storage for total energy self-sufficiency

    Energy Technology Data Exchange (ETDEWEB)

    Lund, P D [Helsinki Univ. of Technology, Espoo (Finland). Dept. of Technical Physics

    1991-01-01

    A new method for optimization of stand-alone photovoltaic-hydrogen energy systems is presented. The methodology gives the optimum values for the solar array and hydrogen storage size for any given system configuration and geographical site. Sensitivity analyses have been performed to study the effect of subsystem efficiencies on the total system performance and sizing, and also to identify possibilities for further improvements. Optimum system configurations have also been derived. The results indicate that a solar-hydrogen energy system is a very promising potential alternative for low power applications requiring a total electricity self-sufficiency. (Author).

  7. The autonomous house: a bio-hydrogen based energy self-sufficient approach.

    Science.gov (United States)

    Chen, Shang-Yuan; Chu, Chen-Yeon; Cheng, Ming-Jen; Lin, Chiu-Yue

    2009-04-01

    In the wake of the greenhouse effect and global energy crisis, finding sources of clean, alternative energy and developing everyday life applications have become urgent tasks. This study proposes the development of an "autonomous house" emphasizing the use of modern green energy technology to reduce environmental load, achieve energy autonomy and use energy intelligently in order to create a sustainable, comfortable living environment. The houses' two attributes are: (1) a self-sufficient energy cycle and (2) autonomous energy control to maintain environmental comfort. The autonomous house thus combines energy-conserving, carbon emission-reducing passive design with active elements needed to maintain a comfortable environment.

  8. A necessary and sufficient condition for the convergence of an AOR iterative method

    International Nuclear Information System (INIS)

    Hu Jiagan

    1992-01-01

    In this paper, a necessary and sufficient condition for the convergence of an AOR iterative method is given under the condition that the coefficient matrix A is consistently ordered and the eigenvalues of the Jacobi matrix of A are all real. With the same method the condition for the convergence of t he extrapolation Gauss-Seidel (EGS) method is also obtained. As an example, the conditions for the model problem are given. The rate of convergence of the EGS method is about twice that of the GS method

  9. Necessary and Sufficient Process leading to Work Smart Standards. Final report

    International Nuclear Information System (INIS)

    1996-11-01

    The Necessary and Sufficient Process leading to Work Smart Standards is a Department of Energy initiative to assure adequate protection for workers, the public, and the environment. The Work Smart Standards initiative directs the Laboratory to develop a set of ES and H standards based on the work performed at the Laboratory and the hazards associated with the work. Berkeley Lab's set of Work Smart Standards includes required Federal, State and local laws and, additionally, national and international standards which represent the highest operating standards of industrial and commercial institutions

  10. $C^1$ actions on manifolds by lattices in Lie groups with sufficiently high rank

    OpenAIRE

    Damjanovic, Danijela; Zhang, Zhiyuan

    2018-01-01

    In this paper we study Zimmer's conjecture for $C^1$ actions of higher-rank lattices of a connected, semisimple Lie group with finite center on compact manifolds. We show that if the Lie group has no compact factor, and all of whose non-compact factors are of ranks in some sense sufficiently large with respect to the dimension of the manifold, then every $C^1$ action of an irreducible, co-compact lattice has a finite image. As a corollary of our results, for every (uniform or non-uniform) lat...

  11. Necessary and Sufficient Process leading to Work Smart Standards. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    The Necessary and Sufficient Process leading to Work Smart Standards is a Department of Energy initiative to assure adequate protection for workers, the public, and the environment. The Work Smart Standards initiative directs the Laboratory to develop a set of ES and H standards based on the work performed at the Laboratory and the hazards associated with the work. Berkeley Lab`s set of Work Smart Standards includes required Federal, State and local laws and, additionally, national and international standards which represent the highest operating standards of industrial and commercial institutions.

  12. On the necessity and sufficiency of local commutativity for causality in quantum mechanics

    International Nuclear Information System (INIS)

    Muynck, W.M. de.

    1984-01-01

    This thesis contributes to the resolution of the question whether quantum mechanics admits an objectivistic interpretation if the description is restricted to the phenomenalistic domain of the quantum mechanical observables. Without touching the realism-phenomenalism dichotomy, this thesis investigates the possibility to disregard the influence of the measurement interaction on the qm measuring results. In the first part, the measuring process is studied and its influence on the objectivity of measuring results. The measurement of a local observable is interpreted as a local operation. Its local commutativity is a necessary condition for macrocausality. In the second part the converse question is studied, viz. Whether local commutativity is sufficient for macrocausality. (Auth.)

  13. INDONESIAN FOOD POLICY: THE PROGRAMS FOR STRENGTHENING FOOD SELF-SUFFICIENCY IN REFORMATION ERA

    Directory of Open Access Journals (Sweden)

    Kamrussamad

    2018-04-01

    Full Text Available The 2012 decree #18, the policy on food states that objective of food implementation is to meet basic human needs and provide fair, equitable, and sustainable benefits based on food sovereignty, food self-sufficiency, and national food security. Food sovereignty, independence and security are fundamental and supports implementation of policies related to food implementation in Indonesia. The 2012 decree #18 stated that food implementation aims to improve ability to produce food independently, provide a variety of food and meet the requirements of security, quality, and nutrition for public consumption.

  14. Monte Carlo based demonstration of sufficiently dimensioned shielding for a Co-60 testing facility

    International Nuclear Information System (INIS)

    Wind, Michael; Beck, Peter; Latocha, Marcin

    2015-01-01

    The electrical properties of electronic equipment can be changed in an ionized radiation field. The knowledge of these changes is necessary for applications in space, in air traffic and nuclear medicine. Experimental tests will be performed in Co-60 radiation fields in the irradiation facility (TEC facility) of the Seibersdorf Labor GmbH that is in construction. The contribution deals with a simulation that is aimed to calculate the local dose rate within and outside the building for demonstration of sufficient dimensioning of the shielding in compliance with the legal dose rate limits.

  15. The Autonomous House: A Bio-Hydrogen Based Energy Self-Sufficient Approach

    Science.gov (United States)

    Chen, Shang-Yuan; Chu, Chen-Yeon; Cheng, Ming-jen; Lin, Chiu-Yue

    2009-01-01

    In the wake of the greenhouse effect and global energy crisis, finding sources of clean, alternative energy and developing everyday life applications have become urgent tasks. This study proposes the development of an “autonomous house” emphasizing the use of modern green energy technology to reduce environmental load, achieve energy autonomy and use energy intelligently in order to create a sustainable, comfortable living environment. The houses’ two attributes are: (1) a self-sufficient energy cycle and (2) autonomous energy control to maintain environmental comfort. The autonomous house thus combines energy-conserving, carbon emission-reducing passive design with active elements needed to maintain a comfortable environment. PMID:19440531

  16. Forty Necessary and Sufficient Conditions for Regularity of Interval Matrices: A survey

    Czech Academy of Sciences Publication Activity Database

    Rohn, Jiří

    2009-01-01

    Roč. 18, - (2009), s. 500-512 E-ISSN 1081-3810 R&D Projects: GA ČR GA201/09/1957; GA ČR GC201/08/J020 Institutional research plan: CEZ:AV0Z10300504 Keywords : interval matrix * regularity * singularity * necessary and sufficient condition * algorithm Subject RIV: BA - General Mathematics Impact factor: 0.892, year: 2009 http://www.math.technion.ac.il/iic/ ela / ela -articles/articles/vol18_pp500-512.pdf

  17. Advances in Applied Mechanics

    OpenAIRE

    2013-01-01

    Advances in Applied Mechanics draws together recent significant advances in various topics in applied mechanics. Published since 1948, Advances in Applied Mechanics aims to provide authoritative review articles on topics in the mechanical sciences, primarily of interest to scientists and engineers working in the various branches of mechanics, but also of interest to the many who use the results of investigations in mechanics in various application areas, such as aerospace, chemical, civil, en...

  18. Perspectives on Applied Ethics

    OpenAIRE

    2007-01-01

    Applied ethics is a growing, interdisciplinary field dealing with ethical problems in different areas of society. It includes for instance social and political ethics, computer ethics, medical ethics, bioethics, envi-ronmental ethics, business ethics, and it also relates to different forms of professional ethics. From the perspective of ethics, applied ethics is a specialisation in one area of ethics. From the perspective of social practice applying eth-ics is to focus on ethical aspects and ...

  19. Applied Neuroscience Laboratory Complex

    Data.gov (United States)

    Federal Laboratory Consortium — Located at WPAFB, Ohio, the Applied Neuroscience lab researches and develops technologies to optimize Airmen individual and team performance across all AF domains....

  20. Paradoxes of Sahrawi Refugees' Educational Migration: Promoting Self-Sufficiency or Renewing Dependency?

    Science.gov (United States)

    Fiddian-Qasmiyeh, Elena

    2011-01-01

    Education is often prioritised by refugee children and families, as well as by their political representatives and international actors alike. This article explores the specificities of the Sahrawi refugee education system, focusing in particular on the nature, motivations and implications of Sahrawi refugee youths' educational migration to Cuba…

  1. Do new and renovated schools and kindergartens secure sufficiently high indoor environmental quality?

    DEFF Research Database (Denmark)

    Wargocki, Pawel; Hviid, Christian Anker; Skupien, Agata

    2016-01-01

    or less similar as their conventional counterparts as regards measured parameters of indoor environment. Subjective evaluations made by pupils and teachers did not always match the physical measurements. There were also differences in subjective evaluations made by children and by teachers. In conclusion...

  2. SUFFICIENT IODINE INTAKE IN SCHOOLCHILDREN FROM THE ZAGREB AREA: ASSESSMENT WITH DRIED BLOD SPOT THYROGLOBULIN AS A NEW FUNCTIONAL BIOMARKER FOR IODINE DEFICIENCY.

    Science.gov (United States)

    Jukić, Tomislav; Zimmermann, Michael Bruce; Granić, Roko; Prpić, Marin; Krilić, Drazena; Juresa, Vesna; Katalenić, Marijan; Kusić, Zvonko

    2015-12-01

    Current methods for assessment of iodine intake in a population comprise measurements of urinary iodine concentration (UIC), thyroid volume by ultrasound (US-Tvol), and newborn TSH. Serum or dried blood spot thyroglobulin (DBS-Tg) is a new promising functional iodine status biomarker in children. In 1996, a new act on universal salt iodination was introduced in Croatia with 25 mg of potassium iodideper kg of salt. In 2002, Croatia finally reached iodine sufficiency. However, in 2009, median UIC in 101 schoolchildren from Zagreb, the capital of Croatia, was 288 µg/L, posing to be excessive. The aim of the study was to assess iodine intake in schoolchildren from the Zagreb area and to evaluate the value of DBS-Tg in schoolchildren as a new functional biomarker of iodine deficiency (and iodine excess). The study was part of a large international study in 6- to 12-year-old children supported by UNICEF, the Swiss Federal Institute of Technology (ETH Zurich) and the International Council for the Control of Iodine Deficiency Disorders (ICCIDD). According to international study results, the median cut-off Tg 40 µg/L indicate iodine sufficiency. The study included 159 schoolchildren (median age 9.1 ± 1.4 years) from Zagreb and a nearby small town of Jastrebarsko with measurements of UIC, US-Tvol, DBS-Tg, T4, TSH and iodine content in salt from households of schoolchildren (KI/kg of salt). Overall median UIC was 205 µg/L (range 1-505 µg/L). Thyroid volumes in schoolchildren measured by US were within the normal range according to reference values. Median DBS-Tg in schoolchildren was 12.1 µg/L with 3% of Tg values > 40 µg/L. High Tg values were in the UIC range 300 µg/L (U-shaped curve of Tg plotted against UIC). All children were euthyroid with geometric mean TSH 0.7 ± 0.3 mU/L and arithmetic mean T4 62 ± 12.5 nmol/L. The mean KI content per kg of salt was 24.9 ± 3.1 mg/kg (range 19-36 mg/kg). Study results indicated iodine sufficiency in schoolchildren from the

  3. TGF-β Signaling Is Necessary and Sufficient for Pharyngeal Arch Artery Angioblast Formation

    Directory of Open Access Journals (Sweden)

    Maryline Abrial

    2017-07-01

    Full Text Available The pharyngeal arch arteries (PAAs are transient embryonic blood vessels that mature into critical segments of the aortic arch and its branches. Although defects in PAA development cause life-threating congenital cardiovascular defects, the molecular mechanisms that orchestrate PAA morphogenesis remain unclear. Through small-molecule screening in zebrafish, we identified TGF-β signaling as indispensable for PAA development. Specifically, chemical inhibition of the TGF-β type I receptor ALK5 impairs PAA development because nkx2.5+ PAA progenitor cells fail to differentiate into tie1+ angioblasts. Consistent with this observation, we documented a burst of ALK5-mediated Smad3 phosphorylation within PAA progenitors that foreshadows angioblast emergence. Remarkably, premature induction of TGF-β receptor activity stimulates precocious angioblast differentiation, thereby demonstrating the sufficiency of this pathway for initiating the PAA progenitor to angioblast transition. More broadly, these data uncover TGF-β as a rare signaling pathway that is necessary and sufficient for angioblast lineage commitment.

  4. Design of fuel cell powered data centers for sufficient reliability and availability

    Science.gov (United States)

    Ritchie, Alexa J.; Brouwer, Jacob

    2018-04-01

    It is challenging to design a sufficiently reliable fuel cell electrical system for use in data centers, which require 99.9999% uptime. Such a system could lower emissions and increase data center efficiency, but the reliability and availability of such a system must be analyzed and understood. Currently, extensive backup equipment is used to ensure electricity availability. The proposed design alternative uses multiple fuel cell systems each supporting a small number of servers to eliminate backup power equipment provided the fuel cell design has sufficient reliability and availability. Potential system designs are explored for the entire data center and for individual fuel cells. Reliability block diagram analysis of the fuel cell systems was accomplished to understand the reliability of the systems without repair or redundant technologies. From this analysis, it was apparent that redundant components would be necessary. A program was written in MATLAB to show that the desired system reliability could be achieved by a combination of parallel components, regardless of the number of additional components needed. Having shown that the desired reliability was achievable through some combination of components, a dynamic programming analysis was undertaken to assess the ideal allocation of parallel components.

  5. A blueprint for complete energy self-sufficiency in British Columbia

    International Nuclear Information System (INIS)

    2007-01-01

    The Endless Energy Project is a partnership between the Globe Foundation, BC Hydro, Day 4 Energy, the Power Technology Alliance, the National Research Council of Canada, and Western Economic Diversification. The purpose of the project is to examine British Columbia's potential to be energy self-sufficient from renewable sources by 2025. Background information on the Endless Energy Project was presented with reference to energy use in all sectors of the economy and energy supply from all sources indigenous to the province. The report discussed global drivers and scenarios as well as energy use trends specific to British Columbia. These trends were related to energy use for residential buildings; commercial sector; domestic transportation; gateway transportation; and industrial sources. The report also provided an outlook for each of these sectors. A large-scale supply outlook was also described for solar; geothermal; wind; hydro; biomass; forest waste to energy potential; ocean wave energy potential; and tidal current systems. The report concluded with a discussion of matching renewable energy supplies to demand. It was concluded that based on a combination of renewable energy supply, cleaner burning fuels, such as hydrogen and ethanol, and energy use reduction in homes, businesses, and public sector operations, British Columbia could reasonably achieve energy self-sufficiency by 2025. tabs., figs

  6. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain?

    Science.gov (United States)

    Domenichiello, Anthony F; Kitson, Alex P; Bazinet, Richard P

    2015-07-01

    Docosahexaenoic acid (DHA) is important for brain function, and can be obtained directly from the diet or synthesized in the body from α-linolenic acid (ALA). Debate exists as to whether DHA synthesized from ALA can provide sufficient DHA for the adult brain, as measures of DHA synthesis from ingested ALA are typically <1% of the oral ALA dose. However, the primary fate of orally administered ALA is β-oxidation and long-term storage in adipose tissue, suggesting that DHA synthesis measures involving oral ALA tracer ingestion may underestimate total DHA synthesis. There is also evidence that DHA synthesized from ALA can meet brain DHA requirements, as animals fed ALA-only diets have brain DHA concentrations similar to DHA-fed animals, and the brain DHA requirement is estimated to be only 2.4-3.8 mg/day in humans. This review summarizes evidence that DHA synthesis from ALA can provide sufficient DHA for the adult brain by examining work in humans and animals involving estimates of DHA synthesis and brain DHA requirements. Also, an update on methods to measure DHA synthesis in humans is presented highlighting a novel approach involving steady-state infusion of stable isotope-labeled ALA that bypasses several limitations of oral tracer ingestion. It is shown that this method produces estimates of DHA synthesis that are at least 3-fold higher than brain uptake rates in rats. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  7. AN ALTERNATIVE APPROACH TO MEET BEEF SELF-SUFFICIENCY IN WEST PAPUA

    Directory of Open Access Journals (Sweden)

    S. Hartono

    2011-09-01

    Full Text Available The main objective of this research is to present an alternative approach to meet beef self-sufficiency in West Papua, Indonesia. It mainly focuses on calculating the needed number of productive cows to enhance beef production in the province. Out of the total farmer households in Manokwari, Indonesia, 189 farmer-respondents were selected as samples of the study. Selection of the sample was based on the number of cattle kept in every age group (less than one (2 years old and the number of productive cows. Secondary data came from the time series data of the number of slaughtered cattle vis-à-vis the population of all districts in West Papua Province from 1980-2008. Data were analyzed using the Partial Adjustment Model (PAM and Ordinary Least Square (OLS method. Results of the study showed that beef self-sufficiency in West Papua depend on the availability of the number of productive cows to produce ready-slaughtered-bull in the previous year. Particularly for West Papua, to produce one unit of bull in the tth –year, with the assumption that cattle mortality is 4.92%, a number of 2.38 animal units AU of productive cows must be provided in the previous two (2 years.

  8. Scheduling of Crude Oil Operations in Refinery without Sufficient Charging Tanks Using Petri Nets

    Directory of Open Access Journals (Sweden)

    Yan An

    2017-05-01

    Full Text Available A short-term schedule for crude oil operations in a refinery should define and sequence the activities in detail. Each activity involves both discrete-event and continuous variables. The combinatorial nature of the scheduling problem makes it difficult to solve. For such a scheduling problem, charging tanks are a type of critical resources. If the number of charging tanks is not sufficient, the scheduling problem is further complicated. This work conducts a study on the scheduling problem of crude oil operations without sufficient charging tanks. In this case, to make a refinery able to operate, a charging tank has to be in simultaneous charging and feeding to a distiller for some time, called simultaneously-charging-and-feeding (SCF mode, leading to disturbance to the oil distillation in distillers. A hybrid Petri net model is developed to describe the behavior of the system. Then, a scheduling method is proposed to find a schedule such that the SCF mode is minimally used. It is computationally efficient. An industrial case study is given to demonstrate the obtained results.

  9. Necessary and sufficient liveness condition of GS3PR Petri nets

    Science.gov (United States)

    Liu, GaiYun; Barkaoui, Kamel

    2015-05-01

    Structural analysis is one of the most important and efficient methods to investigate the behaviour of Petri nets. Liveness is a significant behavioural property of Petri nets. Siphons, as structural objects of a Petri net, are closely related to its liveness. Many deadlock control policies for flexible manufacturing systems (FMS) modelled by Petri nets are implemented via siphon control. Most of the existing methods design liveness-enforcing supervisors by adding control places for siphons based on their controllability conditions. To compute a liveness-enforcing supervisor with as much as permissive behaviour, it is both theoretically and practically significant to find an exact controllability condition for siphons. However, the existing conditions, max, max‧, and max″-controllability of siphons are all overly restrictive and generally sufficient only. This paper develops a new condition called max*-controllability of the siphons in generalised systems of simple sequential processes with resources (GS3PR), which are a net subclass that can model many real-world automated manufacturing systems. We show that a GS3PR is live if all its strict minimal siphons (SMS) are max*-controlled. Compared with the existing conditions, i.e., max-, max‧-, and max″-controllability of siphons, max*-controllability of the SMS is not only sufficient but also necessary. An example is used to illustrate the proposed method.

  10. Measuring what latent fingerprint examiners consider sufficient information for individualization determinations.

    Directory of Open Access Journals (Sweden)

    Bradford T Ulery

    Full Text Available Latent print examiners use their expertise to determine whether the information present in a comparison of two fingerprints (or palmprints is sufficient to conclude that the prints were from the same source (individualization. When fingerprint evidence is presented in court, it is the examiner's determination--not an objective metric--that is presented. This study was designed to ascertain the factors that explain examiners' determinations of sufficiency for individualization. Volunteer latent print examiners (n = 170 were each assigned 22 pairs of latent and exemplar prints for examination, and annotated features, correspondence of features, and clarity. The 320 image pairs were selected specifically to control clarity and quantity of features. The predominant factor differentiating annotations associated with individualization and inconclusive determinations is the count of corresponding minutiae; other factors such as clarity provided minimal additional discriminative value. Examiners' counts of corresponding minutiae were strongly associated with their own determinations; however, due to substantial variation of both annotations and determinations among examiners, one examiner's annotation and determination on a given comparison is a relatively weak predictor of whether another examiner would individualize. The extensive variability in annotations also means that we must treat any individual examiner's minutia counts as interpretations of the (unknowable information content of the prints: saying "the prints had N corresponding minutiae marked" is not the same as "the prints had N corresponding minutiae." More consistency in annotations, which could be achieved through standardization and training, should lead to process improvements and provide greater transparency in casework.

  11. Impaired Hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy: implication in diabetes.

    Science.gov (United States)

    Chapouly, Candice; Yao, Qinyu; Vandierdonck, Soizic; Larrieu-Lahargue, Frederic; Mariani, John N; Gadeau, Alain-Pierre; Renault, Marie-Ange

    2016-02-01

    Microangiopathy, i.e. endothelial dysfunction, has long been suggested to contribute to the development of diabetic neuropathy, although this has never been fully verified. In the present paper, we have identified the role of Hedgehog (Hh) signalling in endoneurial microvessel integrity and evaluated the impact of impaired Hh signalling in endothelial cells (ECs) on nerve function. By using Desert Hedgehog (Dhh)-deficient mice, we have revealed, that in the absence of Dhh, endoneurial capillaries are abnormally dense and permeable. Furthermore, Smoothened (Smo) conditional KO mice clarified that this increased vessel permeability is specifically due to impaired Hh signalling in ECs and is associated with a down-regulation of Claudin5 (Cldn5). Moreover, impairment of Hh signalling in ECs was sufficient to induce hypoalgesia and neuropathic pain. Finally in Lepr(db/db) type 2 diabetic mice, the loss of Dhh expression observed in the nerve was shown to be associated with increased endoneurial capillary permeability and decreased Cldn5 expression. Conversely, systemic administration of the Smo agonist SAG increased Cldn5 expression, decreased endoneurial capillary permeability, and restored thermal algesia to diabetic mice, demonstrating that loss of Dhh expression is crucial in the development of diabetic neuropathy. The present work demonstrates the critical role of Dhh in maintaining blood nerve barrier integrity and demonstrates for the first time that endothelial dysfunction is sufficient to induce neuropathy. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.

  12. Energy self-sufficient sewage wastewater treatment plants: is optimized anaerobic sludge digestion the key?

    Science.gov (United States)

    Jenicek, P; Kutil, J; Benes, O; Todt, V; Zabranska, J; Dohanyos, M

    2013-01-01

    The anaerobic digestion of primary and waste activated sludge generates biogas that can be converted into energy to power the operation of a sewage wastewater treatment plant (WWTP). But can the biogas generated by anaerobic sludge digestion ever completely satisfy the electricity requirements of a WWTP with 'standard' energy consumption (i.e. industrial pollution not treated, no external organic substrate added)? With this question in mind, we optimized biogas production at Prague's Central Wastewater Treatment Plant in the following ways: enhanced primary sludge separation; thickened waste activated sludge; implemented a lysate centrifuge; increased operational temperature; improved digester mixing. With these optimizations, biogas production increased significantly to 12.5 m(3) per population equivalent per year. In turn, this led to an equally significant increase in specific energy production from approximately 15 to 23.5 kWh per population equivalent per year. We compared these full-scale results with those obtained from WWTPs that are already energy self-sufficient, but have exceptionally low energy consumption. Both our results and our analysis suggest that, with the correct optimization of anaerobic digestion technology, even WWTPs with 'standard' energy consumption can either attain or come close to attaining energy self-sufficiency.

  13. Comparison of methods for calculating conditional expectations of sufficient statistics for continuous time Markov chains.

    Science.gov (United States)

    Tataru, Paula; Hobolth, Asger

    2011-12-05

    Continuous time Markov chains (CTMCs) is a widely used model for describing the evolution of DNA sequences on the nucleotide, amino acid or codon level. The sufficient statistics for CTMCs are the time spent in a state and the number of changes between any two states. In applications past evolutionary events (exact times and types of changes) are unaccessible and the past must be inferred from DNA sequence data observed in the present. We describe and implement three algorithms for computing linear combinations of expected values of the sufficient statistics, conditioned on the end-points of the chain, and compare their performance with respect to accuracy and running time. The first algorithm is based on an eigenvalue decomposition of the rate matrix (EVD), the second on uniformization (UNI), and the third on integrals of matrix exponentials (EXPM). The implementation in R of the algorithms is available at http://www.birc.au.dk/~paula/. We use two different models to analyze the accuracy and eight experiments to investigate the speed of the three algorithms. We find that they have similar accuracy and that EXPM is the slowest method. Furthermore we find that UNI is usually faster than EVD.

  14. Comparison of methods for calculating conditional expectations of sufficient statistics for continuous time Markov chains

    Directory of Open Access Journals (Sweden)

    Tataru Paula

    2011-12-01

    Full Text Available Abstract Background Continuous time Markov chains (CTMCs is a widely used model for describing the evolution of DNA sequences on the nucleotide, amino acid or codon level. The sufficient statistics for CTMCs are the time spent in a state and the number of changes between any two states. In applications past evolutionary events (exact times and types of changes are unaccessible and the past must be inferred from DNA sequence data observed in the present. Results We describe and implement three algorithms for computing linear combinations of expected values of the sufficient statistics, conditioned on the end-points of the chain, and compare their performance with respect to accuracy and running time. The first algorithm is based on an eigenvalue decomposition of the rate matrix (EVD, the second on uniformization (UNI, and the third on integrals of matrix exponentials (EXPM. The implementation in R of the algorithms is available at http://www.birc.au.dk/~paula/. Conclusions We use two different models to analyze the accuracy and eight experiments to investigate the speed of the three algorithms. We find that they have similar accuracy and that EXPM is the slowest method. Furthermore we find that UNI is usually faster than EVD.

  15. Hydrodynamic property of the cytoplasm is sufficient to mediate cytoplasmic streaming in the Caenorhabiditis elegans embryo

    Science.gov (United States)

    Niwayama, Ritsuya; Shinohara, Kyosuke; Kimura, Akatsuki

    2011-01-01

    Cytoplasmic streaming is a type of intracellular transport widely seen in nature. Cytoplasmic streaming in Caenorhabditis elegans at the one-cell stage is bidirectional; the flow near the cortex (“cortical flow”) is oriented toward the anterior, whereas the flow in the central region (“cytoplasmic flow”) is oriented toward the posterior. Both cortical flow and cytoplasmic flow depend on non-muscle-myosin II (NMY-2), which primarily localizes in the cortex. The manner in which NMY-2 proteins drive cytoplasmic flow in the opposite direction from remote locations has not been fully understood. In this study, we demonstrated that the hydrodynamic properties of the cytoplasm are sufficient to mediate the forces generated by the cortical myosin to drive bidirectional streaming throughout the cytoplasm. We quantified the flow velocities of cytoplasmic streaming using particle image velocimetry (PIV) and conducted a three-dimensional hydrodynamic simulation using the moving particle semiimplicit method. Our simulation quantitatively reconstructed the quantified flow velocity distribution resolved through PIV analysis. Furthermore, our PIV analyses detected microtubule-dependent flows during the pronuclear migration stage. These flows were reproduced via hydrodynamic interactions between moving pronuclei and the cytoplasm. The agreement of flow dynamics in vivo and in simulation indicates that the hydrodynamic properties of the cytoplasm are sufficient to mediate cytoplasmic streaming in C. elegans embryos. PMID:21730185

  16. Adhesion to the host cell surface is sufficient to mediate Listeria monocytogenes entry into epithelial cells

    Science.gov (United States)

    Ortega, Fabian E.; Rengarajan, Michelle; Chavez, Natalie; Radhakrishnan, Prathima; Gloerich, Martijn; Bianchini, Julie; Siemers, Kathleen; Luckett, William S.; Lauer, Peter; Nelson, W. James; Theriot, Julie A.

    2017-01-01

    The intestinal epithelium is the first physiological barrier breached by the Gram-positive facultative pathogen Listeria monocytogenes during an in vivo infection. Listeria monocytogenes binds to the epithelial host cell receptor E-cadherin, which mediates a physical link between the bacterium and filamentous actin (F-actin). However, the importance of anchoring the bacterium to F-actin through E-cadherin for bacterial invasion has not been tested directly in epithelial cells. Here we demonstrate that depleting αE-catenin, which indirectly links E-cadherin to F-actin, did not decrease L. monocytogenes invasion of epithelial cells in tissue culture. Instead, invasion increased due to increased bacterial adhesion to epithelial monolayers with compromised cell–cell junctions. Furthermore, expression of a mutant E-cadherin lacking the intracellular domain was sufficient for efficient L. monocytogenes invasion of epithelial cells. Importantly, direct biotin-mediated binding of bacteria to surface lipids in the plasma membrane of host epithelial cells was sufficient for uptake. Our results indicate that the only requirement for L. monocytogenes invasion of epithelial cells is adhesion to the host cell surface, and that E-cadherin–mediated coupling of the bacterium to F-actin is not required. PMID:28877987

  17. Engineering human cytochrome P450 enzymes into catalytically self-sufficient chimeras using molecular Lego.

    Science.gov (United States)

    Dodhia, Vikash Rajnikant; Fantuzzi, Andrea; Gilardi, Gianfranco

    2006-10-01

    The membrane-bound human cytochrome P450s have essential roles in the metabolism of endogenous compounds and drugs. Presented here are the results on the construction and characterization of three fusion proteins containing the N-terminally modified human cytochrome P450s CYP2C9, CY2C19 and CYP3A4 fused to the soluble NADPH-dependent oxidoreductase domain of CYP102A1 from Bacillus megaterium. The constructs, CYP2C9/BMR, CYP2C19/BMR and CYP3A4/BMR are well expressed in Escherichia coli as holo proteins. The chimeras can be purified in the absence of detergent and the purified enzymes are both active and correctly folded in the absence of detergent, as demonstrated by circular dichroism and functional studies. Additionally, in comparison with the parent P450 enzyme, these chimeras have greatly improved solubility properties. The chimeras are catalytically self-sufficient and present turnover rates similar to those reported for the native enzymes in reconstituted systems, unlike previously reported mammalian cytochrome P450 fusion proteins. Furthermore the specific activities of these chimeras are not dependent on the enzyme concentration present in the reaction buffer and they do not require the addition of accessory proteins, detergents or phospholipids to be fully active. The solubility, catalytic self-sufficiency and wild-type like activities of these chimeras would greatly simplify the studies of cytochrome P450 mediated drug metabolism in solution.

  18. Osteocalcin is necessary and sufficient to maintain muscle mass in older mice

    Directory of Open Access Journals (Sweden)

    Paula Mera

    2016-10-01

    Full Text Available Objective: A decrease in muscle protein turnover and therefore in muscle mass is a hallmark of aging. Because the circulating levels of the bone-derived hormone osteocalcin decline steeply during aging in mice, monkeys and humans we asked here whether this hormone might regulate muscle mass as mice age. Methods: We examined muscle mass and strength in mice lacking osteocalcin (Ocn−/− or its receptor in all cells (Gprc6a−/− or specifically in myofibers (Gprc6aMck−/− as well as in 9 month-old WT mice receiving exogenous osteocalcin for 28 days. We also examined protein synthesis in WT and Gprc6a−/− mouse myotubes treated with osteocalcin. Results: We show that osteocalcin signaling in myofibers is necessary to maintain muscle mass in older mice in part because it promotes protein synthesis in myotubes without affecting protein breakdown. We further show that treatment with exogenous osteocalcin for 28 days is sufficient to increase muscle mass of 9-month-old WT mice. Conclusion: This study uncovers that osteocalcin is necessary and sufficient to prevent age-related muscle loss in mice. Author Video: Author Video Watch what authors say about their articles Keywords: Osteocalcin, Muscle mass, Aging

  19. Revenue Sufficiency and Reliability in a Zero Marginal Cost Future: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Frew, Bethany A.; Milligan, Michael; Brinkman, Greg; Bloom, Aaron; Clark, Kara; Denholm, Paul

    2016-12-01

    Features of existing wholesale electricity markets, such as administrative pricing rules and policy-based reliability standards, can distort market incentives from allowing generators sufficient opportunities to recover both fixed and variable costs. Moreover, these challenges can be amplified by other factors, including (1) inelastic demand resulting from a lack of price signal clarity, (2) low- or near-zero marginal cost generation, particularly arising from low natural gas fuel prices and variable generation (VG), such as wind and solar, and (3) the variability and uncertainty of this VG. As power systems begin to incorporate higher shares of VG, many questions arise about the suitability of the existing marginal-cost-based price formation, primarily within an energy-only market structure, to ensure the economic viability of resources that might be needed to provide system reliability. This article discusses these questions and provides a summary of completed and ongoing modelling-based work at the National Renewable Energy Laboratory to better understand the impacts of evolving power systems on reliability and revenue sufficiency.

  20. Attended but unseen: visual attention is not sufficient for visual awareness.

    Science.gov (United States)

    Kentridge, R W; Nijboer, T C W; Heywood, C A

    2008-02-12

    Does any one psychological process give rise to visual awareness? One candidate is selective attention-when we attend to something it seems we always see it. But if attention can selectively enhance our response to an unseen stimulus then attention cannot be a sufficient precondition for awareness. Kentridge, Heywood & Weiskrantz [Kentridge, R. W., Heywood, C. A., & Weiskrantz, L. (1999). Attention without awareness in blindsight. Proceedings of the Royal Society of London, Series B, 266, 1805-1811; Kentridge, R. W., Heywood, C. A., & Weiskrantz, L. (2004). Spatial attention speeds discrimination without awareness in blindsight. Neuropsychologia, 42, 831-835.] demonstrated just such a dissociation in the blindsight subject GY. Here, we test whether the dissociation generalizes to the normal population. We presented observers with pairs of coloured discs, each masked by the subsequent presentation of a coloured annulus. The discs acted as primes, speeding discrimination of the colour of the annulus when they matched in colour and slowing it when they differed. We show that the location of attention modulated the size of this priming effect. However, the primes were rendered invisible by metacontrast-masking and remained unseen despite being attended. Visual attention could therefore facilitate processing of an invisible target and cannot, therefore, be a sufficient precondition for visual awareness.

  1. Fuel self-sufficient and low proliferation risk multi-recycling of spent fuel

    International Nuclear Information System (INIS)

    Cho, N. Z.; Hong, S. G.; Kim, T. H.; Greenspan, E.; Kastenberg, W. E.

    1998-01-01

    A preliminary feasibility study has been performed in search of promising nuclear energy systems which could make efficient use of the spent fuel from LWRs and be proliferation resistant. The energy considered consist of a dry process and a fuel-self-sufficient reactor which are synergistic. D 2 O, H 2 O and Pb (or Pb-Bi) are considered for the coolant. The most promising identified consists of Pb-cooled reactors with either an AIROX or an IFR-like reprocessing. H 2 O- (possibly mixed with D 2 O) cooled reactors can be designed to be fuel-self-sufficient and multi-recycle LWR spent fuel, provided they are accelerator driven. Moderator-free, D 2 O-cooled critical reactors can multi-recycle Th- 233 U fuel using IFR-type reprocessing; they are significantly more attractive than their thermal counterparts. H 2 O- (possibly mixed with D 2 O) cooled, accelerator-driven reactors appear attractive for converting Th into denatured 233 U using LWR spent fuel and the IFR process. The CANDU reactor technology appears highly synergistic with accelerator-driven systems. (author). 25 refs., 3 tabs., 6 figs

  2. What Is Applied Linguistics?

    Science.gov (United States)

    James, Carl

    1993-01-01

    Ostensive and expository definitions of applied linguistics are assessed. It is suggested that the key to a meaningful definition lies in the dual articulation of applied linguistics: it is an interface between linguistics and practicality. Its role as an "expert system" is suggested. (45 references) (Author/LB)

  3. Applied social geography

    OpenAIRE

    Hilpert, Markus

    2002-01-01

    Applied social geography : management of spatial planning in reflective discourse ; research perspectives towards a ‚Theory of Practice‘. - In: Geografija in njene aplikativne moˆznosti = Prospects of applied geography. - Ljubljana : Oddelek za Geografijo, Filozofska Fakulteta, 2002. S. 29-39. - (Dela / Oddelek za geografijo Filozofske fakultete v Ljubljani ; 18)

  4. What are applied ethics?

    Science.gov (United States)

    Allhoff, Fritz

    2011-03-01

    This paper explores the relationships that various applied ethics bear to each other, both in particular disciplines and more generally. The introductory section lays out the challenge of coming up with such an account and, drawing a parallel with the philosophy of science, offers that applied ethics may either be unified or disunified. The second section develops one simple account through which applied ethics are unified, vis-à-vis ethical theory. However, this is not taken to be a satisfying answer, for reasons explained. In the third section, specific applied ethics are explored: biomedical ethics; business ethics; environmental ethics; and neuroethics. These are chosen not to be comprehensive, but rather for their traditions or other illustrative purposes. The final section draws together the results of the preceding analysis and defends a disunity conception of applied ethics.

  5. Requirements on qualification, competence and sufficient number of personnel for NPP operation

    International Nuclear Information System (INIS)

    Simon, M.

    2004-01-01

    The safe operation of NPPs presupposes qualified personnel on site in sufficient numbers. While the acquisition and preservation of technical expertise and the qualification of the shift personnel and other staff is well regulated by regulatory guidelines in Germany, there is a lack of such regulations with the exception for shift personnel - for the minimum number of technical personnel required for safe operation of a NPP. By order of the BMU, an attempt was made with this study to work out the requirements for qualification, competence and number of personnel to be maintained at the plant, representing the minimum requirements for safe operation of a NPP. The scope of the project was restricted to requirements for technical plant personnel. The aim was to work out requirements which would be as independent as possible of the existing organisation in a particular power plant. This study therefore does not assume a given organisational structure but was rather more oriented on the work processes in a NPP which are the basis for planning and performing routine work in the plant. For the study a work process model of typical tasks in a NPP had to be developed. Then, the tasks to be performed within the so defined work processes were described (task profiles) on the basis of existing manuals for plant organisation. From these task profiles such tasks were defined or selected which shall not be delegated to external personnel for specific reasons, and which were called vital competences. To keep these vital competences at the plant, an assessment and/or calculation of the necessary number of plant technical personnel was made using the task profiles for responsible personnel, but also by the evaluation of thousands of work orders for maintenance personnel. On the basis of these data, a proposal was made for the minimal number of technical personnel which is necessary to operate a NPP unit safely. Beside of this number, general criteria were developed which should be

  6. Food Self-Sufficiency across scales: How local can we go?

    Science.gov (United States)

    Pradhan, Prajal; Lüdeke, Matthias K. B.; Reusser, Dominik E.; Kropp, Jürgen P.

    2013-04-01

    "Think global, act local" is a phrase often used in sustainability debates. Here, we explore the potential of regions to go for local supply in context of sustainable food consumption considering both the present state and the plausible future scenarios. We analyze data on the gridded crop calories production, the gridded livestock calories production, the gridded feed calories use and the gridded food calories consumption in 5' resolution. We derived these gridded data from various sources: Global Agro-ecological Zone (GAEZ v3.0), Gridded Livestock of the World (GLW), FAOSTAT, and Global Rural-Urban Mapping Project (GRUMP). For scenarios analysis, we considered changes in population, dietary patterns and possibility of obtaining the maximum potential yield. We investigate the food self-sufficiency multiple spatial scales. We start from the 5' resolution (i.e. around 10 km x 10 km in the equator) and look at 8 levels of aggregation ranging from the plausible lowest administrative level to the continental level. Results for the different spatial scales show that about 1.9 billion people live in the area of 5' resolution where enough calories can be produced to sustain their food consumption and the feed used. On the country level, about 4.4 billion population can be sustained without international food trade. For about 1 billion population from Asia and Africa, there is a need for cross-continental food trade. However, if we were able to achieve the maximum potential crop yield, about 2.6 billion population can be sustained within their living area of 5' resolution. Furthermore, Africa and Asia could be food self-sufficient by achieving their maximum potential crop yield and only round 630 million populations would be dependent on the international food trade. However, the food self-sufficiency status might differ under consideration of the future change in population, dietary patterns and climatic conditions. We provide an initial approach for investigating the

  7. Is repair of the protruded meninges sufficient for treatment of meningocele?

    Science.gov (United States)

    Yun-Hai, Song; Nan, Bao; Ping-Ping, Gao; Bo, Yang; Cheng, Chen

    2015-11-01

    The present study aimed to investigate the relationship between meningocele and tethered cord syndrome, diagnosis of meningocele associated with tethered cord syndrome, and when to perform surgery and the best surgical procedure. Sixty-nine children with meningocele who were admitted to Shanghai Children's Medical Center were analyzed. The relationship between meningocele and other lesions causing tethered cord syndrome was studied by combining magnetic resonance imaging (MRI) and intraoperative findings. The MRI results and intraoperative findings showed that 67 children (97%) had associated lesions such as tight filum terminale, fibrous band tethering, spinal cord or cauda equina adhesion, diastematomyelia, arachnoid cyst, and epidermoid cyst. The protruded meninges were repaired, and the intraspinal lesions were treated at the same time. Also, the tethered spinal cord was released. No neurological injuries were observed after surgery. The rate of meningocele associated with tethered cord syndrome is very high. MRI is necessary for the diagnosis of meningocele. Active surgical treatment is recommended immediately after definite diagnosis. During surgery, the surgeon should not only repair the protruded meninges but also explore the spinal canal and release the tethered cord.

  8. Goodbye to Universal Development and Call for Diversified, Democratic Sufficiency and Frugality

    DEFF Research Database (Denmark)

    Buch-Hansen, Mogens

    2012-01-01

    for development within a finite ecological planet calls for radical new thinking about development in terms of sufficiency, frugality and sustainability. The interdisciplinary approach of development studies can play a pertinent role in the necessary redefinition of development in rich and poor countries. This...... World countries materialistic welfare similarly to the developed countries, the poorest countries keep falling further behind in poverty. Rapidly growing emerging economies, however, that all together contain more than half of the world population, now adds up to existing mass consumerism and demand...... changing the established North-South hegemonic world order based in the linear concept of development. This creates two new scenarios. One is the rapidly growing challenges to the global ecosystems, including greenhouse gasses in the atmosphere that with the expected global population by the middle...

  9. Analyzing the Impacts of Increased Wind Power on Generation Revenue Sufficiency: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Qin; Wu, Hongyu; Tan, Jin; Hodge, Bri-Mathias; Li, Wanning; Luo, Cheng

    2016-08-01

    The Revenue Sufficiency Guarantee (RSG), as part of make-whole (or uplift) payments in electricity markets, is designed to recover the generation resources' offer-based production costs that are not otherwise covered by their market revenues. Increased penetrations of wind power will bring significant impacts to the RSG payments in the markets. However, literature related to this topic is sparse. This paper first reviews the industrial practices of implementing RSG in major U.S. independent system operators (ISOs) and regional transmission operators (RTOs) and then develops a general RSG calculation method. Finally, an 18-bus test system is adopted to demonstrate the impacts of increased wind power on RSG payments.

  10. Household behaviour crowds out support for climate change policy when sufficient progress is perceived

    Science.gov (United States)

    Werfel, Seth H.

    2017-07-01

    Household actions and government policies are both necessary to mitigate the effects of climate change. However, household behaviour may crowd out public support for government action by creating the perception of sufficient progress. Here we demonstrate this crowding-out effect in public opinion using survey experiments with more than 14,000 participants in Japan. Subjects who were randomly assigned to report their energy-saving actions following the shutdown of the Fukushima power plant were less likely to support a tax increase on carbon emissions. Treatment effects were larger for subjects who had completed more actions. Further evidence suggests that the crowding-out effect may have been driven by an increase in the perceived importance of individual actions relative to government regulation and a decrease in the perceived issue importance of energy and environmental sustainability.

  11. Sufficient and Necessary Condition to Decide Compatibility for a Class of Interorganizational Workflow Nets

    Directory of Open Access Journals (Sweden)

    Guanjun Liu

    2015-01-01

    Full Text Available Interorganizational Workflow nets (IWF-nets can well model many concurrent systems such as web service composition, in which multiple processes interact via sending/receiving messages. Compatibility of IWF-nets is a crucial criterion for the correctness of these systems. It guarantees that a system has no deadlock, livelock, or dead tasks. In our previous work we proved that the compatibility problem is PSPACE-complete for safe IWF-nets. This paper defines a subclass of IWF-nets that can model many cases about interactions. Necessary and sufficient condition is presented to decide their compatibility, and it depends on the net structures only. Finally, an algorithm is developed based on the condition.

  12. Sufficient conditions for Hadamard well-posedness of a coupled thermo-chemo-poroelastic system

    Directory of Open Access Journals (Sweden)

    Tetyana Malysheva

    2016-01-01

    Full Text Available This article addresses the well-posedness of a coupled parabolic-elliptic system modeling fully coupled thermal, chemical, hydraulic, and mechanical processes in porous formations that impact drilling and borehole stability. The underlying thermo-chemo-poroelastic model is a system of time-dependent parabolic equations describing thermal, solute, and fluid diffusions coupled with Navier-type elliptic equations that attempt to capture the elastic behavior of rock around a borehole. An existence and uniqueness theory for a corresponding initial-boundary value problem is an open problem in the field. We give sufficient conditions for the well-posedness in the sense of Hadamard of a weak solution to a fully coupled parabolic-elliptic initial-boundary value problem describing homogeneous and isotropic media.

  13. Sufficient conditions for a period incrementing big bang bifurcation in one-dimensional maps

    International Nuclear Information System (INIS)

    Avrutin, V; Granados, A; Schanz, M

    2011-01-01

    Typically, big bang bifurcation occurs for one (or higher)-dimensional piecewise-defined discontinuous systems whenever two border collision bifurcation curves collide transversely in the parameter space. At that point, two (feasible) fixed points collide with one boundary in state space and become virtual, and, in the one-dimensional case, the map becomes continuous. Depending on the properties of the map near the codimension-two bifurcation point, there exist different scenarios regarding how the infinite number of periodic orbits are born, mainly the so-called period adding and period incrementing. In our work we prove that, in order to undergo a big bang bifurcation of the period incrementing type, it is sufficient for a piecewise-defined one-dimensional map that the colliding fixed points are attractive and with associated eigenvalues of different signs

  14. Synchronous spikes are necessary but not sufficient for a synchrony code in populations of spiking neurons.

    Science.gov (United States)

    Grewe, Jan; Kruscha, Alexandra; Lindner, Benjamin; Benda, Jan

    2017-03-07

    Synchronous activity in populations of neurons potentially encodes special stimulus features. Selective readout of either synchronous or asynchronous activity allows formation of two streams of information processing. Theoretical work predicts that such a synchrony code is a fundamental feature of populations of spiking neurons if they operate in specific noise and stimulus regimes. Here we experimentally test the theoretical predictions by quantifying and comparing neuronal response properties in tuberous and ampullary electroreceptor afferents of the weakly electric fish Apteronotus leptorhynchus These related systems show similar levels of synchronous activity, but only in the more irregularly firing tuberous afferents a synchrony code is established, whereas in the more regularly firing ampullary afferents it is not. The mere existence of synchronous activity is thus not sufficient for a synchrony code. Single-cell features such as the irregularity of spiking and the frequency dependence of the neuron's transfer function determine whether synchronous spikes possess a distinct meaning for the encoding of time-dependent signals.

  15. Combustion of available fossil-fuel resources sufficient to eliminate the Antarctic Ice Sheet

    Science.gov (United States)

    Winkelmann, R.; Levermann, A.; Ridgwell, A.; Caldeira, K.

    2015-12-01

    The Antarctic Ice Sheet stores water equivalent to 58 meters in global sea-level rise. Here we show in simulations with the Parallel Ice Sheet Model that burning the currently attainable fossil-fuel resources is sufficient to eliminate the ice sheet. With cumulative fossil-fuel emissions of 10 000 GtC, Antarctica is projected to become almost ice-free with an average contribution to sea-level rise exceeding 3 meters per century during the first millennium. Consistent with recent observations and simulations, the West Antarctic Ice Sheet becomes unstable with 600 to 800 GtC of additional carbon emissions. Beyond this additional carbon release, the destabilization of ice basins in both West- and East Antarctica results in a threshold-increase in global sea level. Unabated carbon emissions thus threaten the Antarctic Ice Sheet in its entirety with associated sea-level rise that far exceeds that of all other possible sources.

  16. Combustion of available fossil fuel resources sufficient to eliminate the Antarctic Ice Sheet.

    Science.gov (United States)

    Winkelmann, Ricarda; Levermann, Anders; Ridgwell, Andy; Caldeira, Ken

    2015-09-01

    The Antarctic Ice Sheet stores water equivalent to 58 m in global sea-level rise. We show in simulations using the Parallel Ice Sheet Model that burning the currently attainable fossil fuel resources is sufficient to eliminate the ice sheet. With cumulative fossil fuel emissions of 10,000 gigatonnes of carbon (GtC), Antarctica is projected to become almost ice-free with an average contribution to sea-level rise exceeding 3 m per century during the first millennium. Consistent with recent observations and simulations, the West Antarctic Ice Sheet becomes unstable with 600 to 800 GtC of additional carbon emissions. Beyond this additional carbon release, the destabilization of ice basins in both West and East Antarctica results in a threshold increase in global sea level. Unabated carbon emissions thus threaten the Antarctic Ice Sheet in its entirety with associated sea-level rise that far exceeds that of all other possible sources.

  17. From constraint to sufficiency. The decoupling of energy and carbon from human needs, 1975-2005

    Energy Technology Data Exchange (ETDEWEB)

    Steinberger, Julia K. [Institute of Social Ecology, University of Klagenfurt, Vienna (Austria); Roberts, J. Timmons [Center for Environmental Studies, Brown University, Providence, RI (United States)

    2010-12-15

    We investigate the relationship between human needs, energy consumption and carbon emissions for several indicators of human development: life expectancy, literacy, income and the Human Development Index. We find that high human development can be achieved at moderate energy and carbon levels; increasing energy and carbon past this level does not necessarily contribute to higher living standards. By conducting a novel longitudinal analysis from 1975 to 2005, we observe a previously undetected decoupling of the per capita energy and carbon required for human needs. If resources were equally distributed, current energy and carbon levels would be more than sufficient to satisfy global human needs at high levels of human development. By projecting current trends to 2030, we demonstrate that the global energy consumption and carbon emissions required to satisfy human needs will decrease with time, despite growth in population. (author)

  18. Sufficient conditions for optimality for a mathematical model of drug treatment with pharmacodynamics

    Directory of Open Access Journals (Sweden)

    Maciej Leszczyński

    2017-01-01

    Full Text Available We consider an optimal control problem for a general mathematical model of drug treatment with a single agent. The control represents the concentration of the agent and its effect (pharmacodynamics is modelled by a Hill function (i.e., Michaelis-Menten type kinetics. The aim is to minimize a cost functional consisting of a weighted average related to the state of the system (both at the end and during a fixed therapy horizon and to the total amount of drugs given. The latter is an indirect measure for the side effects of treatment. It is shown that optimal controls are continuous functions of time that change between full or no dose segments with connecting pieces that take values in the interior of the control set. Sufficient conditions for the strong local optimality of an extremal controlled trajectory in terms of the existence of a solution to a piecewise defined Riccati differential equation are given.

  19. The Necessary and Sufficient Closure Process Completion Report for Purex FacilitySurveillance and Maintenance

    International Nuclear Information System (INIS)

    Gerald, J.W.

    1997-10-01

    This document completes the U.S. Department of Energy Closure Process for Necessary and Sufficient Sets of Standards process for the Plutonium Uranium Extraction facility located at the Hanford Site in Washington State. This documentation is provided to support the Work Smart Standards set identified for the long-term surveillance and maintenance of PUREX. This report is organized into two volumes. Volume 1 contains the following sections: Section 1: Provides an introduction for the document Section 2: Provides a basis for initiating the N ampersand S process Section 3: Defines the work and hazards to be addressed Section 4: Identifies the N ampersand S set of standards and requirements Section 5: Provides the justification for adequacy of the work smart standards Section 6: Shows the criteria and qualifications of the teams Section 7: Describes the stakeholder participation and concerns Section 8: Provides a list of references used within the document

  20. Sufficient conditions for a period incrementing big bang bifurcation in one-dimensional maps

    Science.gov (United States)

    Avrutin, V.; Granados, A.; Schanz, M.

    2011-09-01

    Typically, big bang bifurcation occurs for one (or higher)-dimensional piecewise-defined discontinuous systems whenever two border collision bifurcation curves collide transversely in the parameter space. At that point, two (feasible) fixed points collide with one boundary in state space and become virtual, and, in the one-dimensional case, the map becomes continuous. Depending on the properties of the map near the codimension-two bifurcation point, there exist different scenarios regarding how the infinite number of periodic orbits are born, mainly the so-called period adding and period incrementing. In our work we prove that, in order to undergo a big bang bifurcation of the period incrementing type, it is sufficient for a piecewise-defined one-dimensional map that the colliding fixed points are attractive and with associated eigenvalues of different signs.

  1. Is the precision of human radiation tolerance estimates sufficient for radiation emergency management

    International Nuclear Information System (INIS)

    Lushbaugh, C.C.; Huebner, K.F.; Fry, S.A.; Ricks, R.C.

    1982-01-01

    Retrospective clinical evaluations of the deleterious consequences of accidental and therapeutic radiation exposures have provided working estimates of human radiation tolerance of variable accuracy. Their inaccuracy results from the fact that in accidents, where normal persons have been irradiated, doses have usually been unknown, whereas in radiotherapy, where doses are known precisely, the additivity of various diseases and cellular abnormalities upon final radiosensitivity remains largely unknown. Even so, from follow-up studies of radiation-accident victims, human radiation biology is not known to be qualitatively different from that of other animals and so the mechanisms of human radiation lethality are sufficiently understood to dictate therapeutic measures and suggest radiation dosage limits for their effectiveness for a few irradiated patients or where large populations are exposed under austere conditions. (author)

  2. The Relationship Between Maternal Attachment, Perceived Social Support and Breast-Feeding Sufficiency

    International Nuclear Information System (INIS)

    Cinar, N.; Kose, D.; Altinkaynak, S.

    2015-01-01

    Objective: To determine the relationship between maternal attachment, perceived social support and breast-feeding sufficiency. Study Design: Descriptive correlational design. Place and Duration of Study: A state hospital and two family health centers in Sakarya, Turkey, between June to December 2011. Methodology: The sample was 122 voluntary mothers who had healthy babies of 1 - 2 months old. The data were collected by a Personal Information Form, Maternal Attachment Inventory (MAI), Multidimensional Scale of Perceived Social Support (MSPSS) and Breast-feeding Self-Efficacy Scale-Short Form (BSES-SF). The data collected were analysed by percentage distribution, mean square, independent sample t-test, Mann-Whitney U, Kruskall-Wallis and Pearson correlation. Results: The mean age of the mothers was 25.01 ± 2.2 years, and 48.4% of them were primary school graduates. BSESSF was 61.02 ± 8.44 (16 - 70), MAI was 99.07 ± 7.19 (56 - 100) and MSPSS was 66.40 ± 13.58 (37 - 84). There was a positive, medium level, significant relationship between the total scores of BSES-SF and MAI (r=0.370, p < 0.001). There was a positive, medium level, significant relationship between the total score of BSES-SF and the score from family subdimension of MSPSS (r=0.255, p < 0.01).There was a positive, medium level, significant relationship between the total score of MAI and the total score of family subdimension of MSPSS (r=0.339, p < 0.001). Conclusion: Successful maternal attachment and familial support positively affected the breast-feeding sufficiency of the mother. (author)

  3. Information system support as a critical success factor for chronic disease management: Necessary but not sufficient.

    Science.gov (United States)

    Green, Carolyn J; Fortin, Patricia; Maclure, Malcolm; Macgregor, Art; Robinson, Sylvia

    2006-12-01

    Improvement of chronic disease management in primary care entails monitoring indicators of quality over time and across patients and practices. Informatics tools are needed, yet implementing them remains challenging. To identify critical success factors enabling the translation of clinical and operational knowledge about effective and efficient chronic care management into primary care practice. A prospective case study of positive deviants using key informant interviews, process observation, and document review. A chronic disease management (CDM) collaborative of primary care physicians with documented improvement in adherence to clinical practice guidelines using a web-based patient registry system with CDM guideline-based flow sheet. Thirty community-based physician participants using predominantly paper records, plus a project management team including the physician lead, project manager, evaluator and support team. A critical success factor (CSF) analysis of necessary and sufficient pathways to the translation of knowledge into clinical practice. A web-based CDM 'toolkit' was found to be a direct CSF that allowed this group of physicians to improve their practice by tracking patient care processes using evidence-based clinical practice guideline-based flow sheets. Moreover, the information and communication technology 'factor' was sufficient for success only as part of a set of seven direct CSF components including: health delivery system enhancements, organizational partnerships, funding mechanisms, project management, practice models, and formal knowledge translation practices. Indirect factors that orchestrated success through the direct factor components were also identified. A central insight of this analysis is that a comprehensive quality improvement model was the CSF that drew this set of factors into a functional framework for successful knowledge translation. In complex primary care settings environment where physicians have low adoption rates of

  4. Induction of ceruloplasmin synthesis by interleukin-1 in copper deficient and copper sufficient rats

    International Nuclear Information System (INIS)

    Barber, E.F.; Cousins, R.J.

    1986-01-01

    Ceruloplasmin (Cp) is a copper-containing plasma protein important in the body's acute phase defense system. In copper sufficient rats given two injections of interleukin-1 (IL-1) at 0 and 8 h, ceruloplasmin activity began to significantly increase within 6 h, but did not peak until at least 24 h. The 24 h stimulated activity was 84 +/- 2 umole p-phenylene diamine (pPD) oxidized x min -1 x L -1 compared to a control of 43 +/- 5. These rats were injected with 100uCi 3 H-leucine (ip) 2 h before sacrifice to label newly synthesized proteins. When the 3 H immunoprecipitated by rabbit anti-rat Cp serum is expressed as a percent of the 3 H precipitated by trichloroacetic acid (TCA), the basal Cp synthesis rate was 3% of the total serum protein synthesis. The rate of Cp synthesis peaked 12 h after IL-1 injection at 7% of total serum protein synthesis and by 24 h was back to the basal rate. In copper deficient rats, IL-1 given with copper induced pPD oxidase activity, while IL-1 given alone did not stimulate activity. The basal Cp synthesis rate in these rats was 3%, the same as in the copper sufficient rats. In copper deficient rats, the Cp synthesis rate was induced by IL-1 with or without an injection of copper. Therefore, if dietary copper is in short supply, then although Cp synthesis is induced by this mediator of host defense mechanisms, Cp cannot carry out its functions

  5. Optically-Induced Neuronal Activity Is Sufficient to Promote Functional Motor Axon Regeneration In Vivo.

    Directory of Open Access Journals (Sweden)

    Patricia J Ward

    Full Text Available Peripheral nerve injuries are common, and functional recovery is very poor. Beyond surgical repair of the nerve, there are currently no treatment options for these patients. In experimental models of nerve injury, interventions (such as exercise and electrical stimulation that increase neuronal activity of the injured neurons effectively enhance axon regeneration. Here, we utilized optogenetics to determine whether increased activity alone is sufficient to promote motor axon regeneration. In thy-1-ChR2/YFP transgenic mice in which a subset of motoneurons express the light-sensitive cation channel, channelrhodopsin (ChR2, we activated axons in the sciatic nerve using blue light immediately prior to transection and surgical repair of the sciatic nerve. At four weeks post-injury, direct muscle EMG responses evoked with both optical and electrical stimuli as well as the ratio of these optical/electrical evoked EMG responses were significantly greater in mice that received optical treatment. Thus, significantly more ChR2+ axons successfully re-innervated the gastrocnemius muscle in mice that received optical treatment. Sections of the gastrocnemius muscles were reacted with antibodies to Synaptic Vesicle Protein 2 (SV2 to quantify the number of re-occupied motor endplates. The number of SV2+ endplates was greater in mice that received optical treatment. The number of retrogradely-labeled motoneurons following intramuscular injection of cholera toxin subunit B (conjugated to Alexa Fluor 555 was greater in mice that received optical treatment. Thus, the acute (1 hour, one-time optical treatment resulted in robust, long-lasting effects compared to untreated animals as well as untreated axons (ChR2-. We conclude that neuronal activation is sufficient to promote motor axon regeneration, and this regenerative effect is specific to the activated neurons.

  6. Overexpression of ERβ is sufficient to inhibit hypoxia-inducible factor-1 transactivation

    International Nuclear Information System (INIS)

    Park, Choa; Lee, YoungJoo

    2014-01-01

    Highlights: • We examined the effect of ERβ specific ligand on HIF-1 inhibition. • DPN down-regulates the ARNT protein levels in PC3 cells. • DPN did not show additional effect in ERβ transfected MCF-7 cells. • Our study shows that unliganded ERβ is sufficient to inhibit HIF-1 in systems of overexpression. - Abstract: Estrogen receptor (ER) β is predicted to play an important role in the prevention of breast cancer development and progression. We have previously shown that ERβ suppresses hypoxia inducible factor (HIF)-1-mediated transcription through aryl hydrocarbon receptor nuclear translocator (ARNT) degradation via ubiquitination processes. In this study, we attempted to examine the effect of ERβ specific ligand on HIF-1 inhibition in ERβ positive PC3 cells and ERβ transfected MCF-7 cells. ERβ specific agonist diarylpropionitrile (DPN) stimulated estrogen response element (ERE)-luciferase activity in a similar fashion to estradiol in PC3 cells. We observed that DPN down-regulates the ARNT protein levels leading to an attenuation of hypoxia-induced hypoxia response element (HRE)-driven luciferase reporter gene activation in PC3 cells. Treatment of DPN reduced vascular endothelial growth factor (VEGF) expression and co-treatment with ERβ specific antagonist PHTPP abrogated the effect in PC3 cells. We then examined the effect of DPN in ERβ transfected MCF-7 cells. HIF-1 transcriptional activity repression by ERβ was not further reduced by DPN, as examined by HRE-driven luciferase assays. Expression of ERβ significantly decreased VEGF secretion and ARNT expression under hypoxic conditions. However, DPN did not additionally affect this suppression in MCF-7 cells transfected with ERβ. This result shows that unliganded ERβ is sufficient to inhibit HIF-1 in systems of overexpression

  7. Overexpression of ERβ is sufficient to inhibit hypoxia-inducible factor-1 transactivation

    Energy Technology Data Exchange (ETDEWEB)

    Park, Choa; Lee, YoungJoo, E-mail: yjlee@sejong.ac.kr

    2014-07-18

    Highlights: • We examined the effect of ERβ specific ligand on HIF-1 inhibition. • DPN down-regulates the ARNT protein levels in PC3 cells. • DPN did not show additional effect in ERβ transfected MCF-7 cells. • Our study shows that unliganded ERβ is sufficient to inhibit HIF-1 in systems of overexpression. - Abstract: Estrogen receptor (ER) β is predicted to play an important role in the prevention of breast cancer development and progression. We have previously shown that ERβ suppresses hypoxia inducible factor (HIF)-1-mediated transcription through aryl hydrocarbon receptor nuclear translocator (ARNT) degradation via ubiquitination processes. In this study, we attempted to examine the effect of ERβ specific ligand on HIF-1 inhibition in ERβ positive PC3 cells and ERβ transfected MCF-7 cells. ERβ specific agonist diarylpropionitrile (DPN) stimulated estrogen response element (ERE)-luciferase activity in a similar fashion to estradiol in PC3 cells. We observed that DPN down-regulates the ARNT protein levels leading to an attenuation of hypoxia-induced hypoxia response element (HRE)-driven luciferase reporter gene activation in PC3 cells. Treatment of DPN reduced vascular endothelial growth factor (VEGF) expression and co-treatment with ERβ specific antagonist PHTPP abrogated the effect in PC3 cells. We then examined the effect of DPN in ERβ transfected MCF-7 cells. HIF-1 transcriptional activity repression by ERβ was not further reduced by DPN, as examined by HRE-driven luciferase assays. Expression of ERβ significantly decreased VEGF secretion and ARNT expression under hypoxic conditions. However, DPN did not additionally affect this suppression in MCF-7 cells transfected with ERβ. This result shows that unliganded ERβ is sufficient to inhibit HIF-1 in systems of overexpression.

  8. Necessary and sufficient conditions for R₀ to be a sum of contributions of fertility loops.

    Science.gov (United States)

    Rueffler, Claus; Metz, Johan A J

    2013-03-01

    Recently, de-Camino-Beck and Lewis (Bull Math Biol 69:1341-1354, 2007) have presented a method that under certain restricted conditions allows computing the basic reproduction ratio R₀ in a simple manner from life cycle graphs, without, however, giving an explicit indication of these conditions. In this paper, we give various sets of sufficient and generically necessary conditions. To this end, we develop a fully algebraic counterpart of their graph-reduction method which we actually found more useful in concrete applications. Both methods, if they work, give a simple algebraic formula that can be interpreted as the sum of contributions of all fertility loops. This formula can be used in e.g. pest control and conservation biology, where it can complement sensitivity and elasticity analyses. The simplest of the necessary and sufficient conditions is that, for irreducible projection matrices, all paths from birth to reproduction have to pass through a common state. This state may be visible in the state representation for the chosen sampling time, but the passing may also occur in between sampling times, like a seed stage in the case of sampling just before flowering. Note that there may be more than one birth state, like when plants in their first year can already have different sizes at the sampling time. Also the common state may occur only later in life. However, in all cases R₀ allows a simple interpretation as the expected number of new individuals that in the next generation enter the common state deriving from a single individual in this state. We end with pointing to some alternative algebraically simple quantities with properties similar to those of R₀ that may sometimes be used to good effect in cases where no simple formula for R₀ exists.

  9. A pacemaker magnet check alone is sufficient for the majority of patients postpacemaker implant.

    Science.gov (United States)

    Jones, Michael A; Wong, Kelvin C K; Qureshi, Norman; Rajappan, Kim; Bashir, Yaver; Betts, Timothy R

    2014-12-01

    Patients postpacemaker implant can undergo a full assessment by pacing system programmer (PSP) or a magnet check. The former takes longer, but provides more detailed information; a magnet-mode assessment is faster, but provides only capture data in an asynchronous pacing mode. A magnet-mode assessment alone may be sufficient in most cases, and current clinical practice varies considerably. A retrospective single-center assessment of all pacemaker implants receiving PSP and magnet checks between September 2009 and April 2010. Patient records were reviewed. The results of PSP and magnet checks and any subsequent device-related management were noted. A total of 168 patients underwent pacemaker implantation, magnet-mode assessment, and then PSP interrogation during this period. Magnet-mode assessment revealed a problem in only one patient-failure of atrial capture, leading to subsequent atrial lead repositioning. None of the remaining 167 patients have a serious problem at PSP interrogation; six had minor issues at PSP check, none of which required repeat surgical intervention. The magnet-mode test only provides information on lead capture in an asynchronous pacing mode, which is the most essential data postoperatively. Our study has suggested that a magnet-mode assessment without PSP interrogation may be sufficient in the immediate postimplant assessment of these patients. Routine postimplant PSP interrogation is time consuming, labor intensive, and adds only minimal additional benefit to the safe management of these patients above and beyond a magnet check, coupled with informed assessment of the associated electrocardiogram/rhythm strip, clinical examination, and chest x-ray. ©2014 Wiley Periodicals, Inc.

  10. Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease.

    Science.gov (United States)

    Wang, Wang; Patel, Vaibhav B; Parajuli, Nirmal; Fan, Dong; Basu, Ratnadeep; Wang, Zuocheng; Ramprasath, Tharmarajan; Kassiri, Zamaneh; Penninger, Josef M; Oudit, Gavin Y

    2014-08-01

    Angiotensin-converting enzyme 2 (ACE2) metabolizes Ang II into Ang 1-7 thereby negatively regulating the renin-angiotensin system. However, heart disease in humans and in animal models is associated with only a partial loss of ACE2. ACE2 is an X-linked gene; and as such, we tested the clinical relevance of a partial loss of ACE2 by using female ACE2(+/+) (wildtype) and ACE2(+/-) (heterozygote) mice. Pressure overload in ACE2(+/-) mice resulted in greater LV dilation and worsening systolic and diastolic dysfunction. These changes were associated with increased myocardial fibrosis, hypertrophy, and upregulation of pathological gene expression. In response to Ang II infusion, there was increased NADPH oxidase activity and myocardial fibrosis resulting in the worsening of Ang II-induced diastolic dysfunction with a preserved systolic function. Ang II-mediated cellular effects in cultured adult ACE2(+/-) cardiomyocytes and cardiofibroblasts were exacerbated. Ang II-mediated pathological signaling worsened in ACE2(+/-) hearts characterized by an increase in the phosphorylation of ERK1/2 and JNK1/2 and STAT-3 pathways. The ACE2(+/-) mice showed an exacerbated pressor response with increased vascular fibrosis and stiffness. Vascular superoxide and nitrotyrosine levels were increased in ACE2(+/-) vessels consistent with increased vascular oxidative stress. These changes occurred with increased renal fibrosis and superoxide production. Partial heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease secondary to pressure overload and Ang II infusion. Heart disease in humans with idiopathic dilated cardiomyopathy is associated with a partial loss of ACE2. Heterozygote female ACE2 mutant mice showed enhanced susceptibility to pressure overload-induced heart disease. Heterozygote female ACE2 mutant mice showed enhanced susceptibility to Ang II-induced heart and vascular diseases. Partial loss of ACE2 is sufficient to enhance the susceptibility to

  11. Applied Mathematics Seminar 1982

    International Nuclear Information System (INIS)

    1983-01-01

    This report contains the abstracts of the lectures delivered at 1982 Applied Mathematics Seminar of the DPD/LCC/CNPq and Colloquy on Applied Mathematics of LCC/CNPq. The Seminar comprised 36 conferences. Among these, 30 were presented by researchers associated to brazilian institutions, 9 of them to the LCC/CNPq, and the other 6 were given by visiting lecturers according to the following distribution: 4 from the USA, 1 from England and 1 from Venezuela. The 1981 Applied Mathematics Seminar was organized by Leon R. Sinay and Nelson do Valle Silva. The Colloquy on Applied Mathematics was held from october 1982 on, being organized by Ricardo S. Kubrusly and Leon R. Sinay. (Author) [pt

  12. Handbook of Applied Analysis

    CERN Document Server

    Papageorgiou, Nikolaos S

    2009-01-01

    Offers an examination of important theoretical methods and procedures in applied analysis. This book details the important theoretical trends in nonlinear analysis and applications to different fields. It is suitable for those working on nonlinear analysis.

  13. Applying contemporary statistical techniques

    CERN Document Server

    Wilcox, Rand R

    2003-01-01

    Applying Contemporary Statistical Techniques explains why traditional statistical methods are often inadequate or outdated when applied to modern problems. Wilcox demonstrates how new and more powerful techniques address these problems far more effectively, making these modern robust methods understandable, practical, and easily accessible.* Assumes no previous training in statistics * Explains how and why modern statistical methods provide more accurate results than conventional methods* Covers the latest developments on multiple comparisons * Includes recent advanc

  14. Financial Consumer Protection in the EU : Towards a Self-Sufficient European Contract Law for Consumer Financial Services?

    NARCIS (Netherlands)

    Cherednychenko, O.O.

    2014-01-01

    The rapid expansion of European contract law in the field of consumer financial services gives rise to the question to what extent it is self-sufficient. A self-sufficient European contract law presupposes the existence of an EU-made and EU-enforced contract-related legal order which is largely

  15. Autonomy of the child in the South African context: is a 12 year old of sufficient maturity to consent to medical treatment?

    Science.gov (United States)

    Ganya, Wandile; Kling, Sharon; Moodley, Keymanthri

    2016-11-02

    A child is a developing person with evolving capacities that include autonomy, mental (decisional) capacity and capacity to assume responsibility. Hence, children are entitled to participatory (autonomy) rights in South Africa as observed in the Children's Act 38 of 2005. According to section 129 of the Act a child may consent to his or her own medical treatment provided that he or she is over the age of 12 years and is of sufficient maturity and decisional capacity to understand the various implications of the treatment including the risks and benefits thereof. However, the Act does not provide a definition for what qualifies as 'sufficient maturity' nor does it stipulate how health professionals ought to assess the decisional capacity of a child. In addition, South Africa is a culturally diverse country. The Western liberal notion of autonomy may not necessarily find equal prominence in the mores of people with a different worldview. Hence we demonstrate a few salient comparisons between legal liberal moral theory and African communitarianism as pertinent to the autonomy of the child. Children are rights-holders by virtue of their humanity. Their dignity as individual human persons affords them the entitlement to human rights as contemplated under the Constitution of the Republic of South Africa. However, contrary to the traditional Western notion of individual autonomous persons African societies hold a communalistic notion of person hence there is less regard for individual autonomy and rights with more emphasis on the communal good and maintaining the continuity of relationships and interdependencies shared within a community. A child considered in this view is not regarded as a full person. This implies that decisions concerning the child, including consent to medical treatment are discussed and determined by the community to which the child belongs. Lastly, in this article, we draw on the notion of capacity for responsibility to produce a pragmatic

  16. Children and adolescents referred for treatment of anxiety disorders: differences in clinical characteristics.

    Science.gov (United States)

    Waite, Polly; Creswell, Cathy

    2014-01-01

    Reports of the clinical characteristics of children and adolescents with anxiety disorders are typically based on community populations or from clinical samples with exclusion criterion applied. Little is known about the clinical characteristics of children and adolescents routinely referred for treatment for anxiety disorders. Furthermore, children and adolescents are typically treated as one homogeneous group although they may differ in ways that are clinically meaningful. A consecutive series of children (n=100, aged 6-12 years) and adolescents (n=100, aged 13-18 years), referred to a routine clinical service, were assessed for anxiety and comorbid disorders, school refusal and parental symptoms of psychopathology. Children with a primary anxiety disorder were significantly more likely to be diagnosed with separation anxiety disorder than adolescents. Adolescents with a primary anxiety disorder had significantly higher self and clinician rated anxiety symptoms and had more frequent primary diagnoses of social anxiety disorder, diagnoses and symptoms of mood disorders, and irregular school attendance. Childhood and adolescence were considered categorically as distinct, developmental periods; in reality changes would be unlikely to occur in such a discrete manner. The finding that children and adolescents with anxiety disorders have distinct clinical characteristics has clear implications for treatment. Simply adapting treatments designed for children to make the materials more 'adolescent-friendly' is unlikely to sufficiently meet the needs of adolescents. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

  17. Physical activity interventions in Danish primary schools – how do we attain sufficient implementation?

    DEFF Research Database (Denmark)

    Johansen, Danielle Louise Nørager

    Aim: Physical activity (PA) holds important health benefits for children and youth on reducing the risk of obesity, non-communicable diseases such as cardiovascular diseases and type-II-diabetes, and on increasing children’s well-being, academic achievement, cognition etc. In August 2014 a reform...... as the overall methodical approach. Various factors for implementation of physical activity interventions in a school setting were identified using a scoping review of the scientific literature and by exploring grey literature. Using a snowball sampling method, a group of experts (organizations, municipalities...

  18. Problems of applied geochemistry

    Energy Technology Data Exchange (ETDEWEB)

    Ovchinnikov, L N

    1983-01-01

    The concept of applied geochemistry was introduced for the first time by A. Ye. Fersman. He linked the branched and complicated questions of geochemistry with specific problems of developing the mineral and raw material base of our country. Geochemical prospecting and geochemistry of mineral raw materials are the most important sections of applied geochemistry. This now allows us the right to view applied geochemistry as a sector of science which applies geochemical methodology, set of geochemical methods of analysis, synthesis, geological interpretation of data based on laws governing theoretical geochemistry to the solution of different tasks of geology, petrology, tectonics, stratigraphy, science of minerals and other geological sciences, and also the technology of mineral raw materials, interrelationships of man and nature (ecogeochemistry, technogeochemistry, agrogeochemistry). The main problem of applied geochemistry, geochemistry of ore fields is the prehistory of ore formation. This is especially important for metallogenic and forecasting constructions, for an understanding of the reasons for the development of fields and the detection of laws governing their distribution, their genetic links with the general geological processes and the products of these processes.

  19. Adenosine A(2A) receptors are necessary and sufficient to trigger memory impairment in adult mice.

    Science.gov (United States)

    Pagnussat, N; Almeida, A S; Marques, D M; Nunes, F; Chenet, G C; Botton, P H S; Mioranzza, S; Loss, C M; Cunha, R A; Porciúncula, L O

    2015-08-01

    Caffeine (a non-selective adenosine receptor antagonist) prevents memory deficits in aging and Alzheimer's disease, an effect mimicked by adenosine A2 A receptor, but not A1 receptor, antagonists. Hence, we investigated the effects of adenosine receptor agonists and antagonists on memory performance and scopolamine-induced memory impairment in mice. We determined whether A2 A receptors are necessary for the emergence of memory impairments induced by scopolamine and whether A2 A receptor activation triggers memory deficits in naïve mice, using three tests to assess short-term memory, namely the object recognition task, inhibitory avoidance and modified Y-maze. Scopolamine (1.0 mg·kg(-1) , i.p.) impaired short-term memory performance in all three tests and this scopolamine-induced amnesia was prevented by the A2 A receptor antagonist (SCH 58261, 0.1-1.0 mg·kg(-1) , i.p.) and by the A1 receptor antagonist (DPCPX, 0.2-5.0 mg·kg(-1) , i.p.), except in the modified Y-maze where only SCH58261 was effective. Both antagonists were devoid of effects on memory or locomotion in naïve rats. Notably, the activation of A2 A receptors with CGS 21680 (0.1-0.5 mg·kg(-1) , i.p.) before the training session was sufficient to trigger memory impairment in the three tests in naïve mice, and this effect was prevented by SCH 58261 (1.0 mg·kg(-1) , i.p.). Furthermore, i.c.v. administration of CGS 21680 (50 nmol) also impaired recognition memory in the object recognition task. These results show that A2 A receptors are necessary and sufficient to trigger memory impairment and further suggest that A1 receptors might also be selectively engaged to control the cholinergic-driven memory impairment. © 2015 The British Pharmacological Society.

  20. Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance.

    Science.gov (United States)

    Liang, X; Syed, A K; Russell, S R; Ware, J; Li, R

    2016-02-01

    ESSENTIALS: Many anti-glycoprotein (GP)Ibα antibodies induce platelet clearance in a dimer-dependent manner. Characterization of monoclonal antibodies that bind the mechanosensitive domain (MSD) of GPIbα. An anti-MSD antibody binds two copies of GPIbα in platelets but does not induce platelet clearance. The prevailing clustering model of GPIbα signaling is incorrect or needs revision. The mechanism of platelet clearance is not clear. Many antibodies binding the membrane-distal ligand-binding domain of glycoprotein (GP)Ibα induce rapid clearance of platelets and acute thrombocytopenia, which requires the bifurcated antibody structure. It was thought that binding of these antibodies induced lateral dimerization or clustering of GPIbα in the plasma membrane, which leads to downstream signaling and platelet clearance. However, many antibodies targeting GPIbβ and GPIX, which are associated with GPIbα in the GPIb-IX complex, do not induce platelet clearance, which is in contradiction to the clustering model. To test whether dimerization or clustering of GPIbα is sufficient to transmit the signal that leads to platelet clearance. We have recently raised several mAbs targeting the mechanosensitive domain (MSD) of GPIbα. Binding of these anti-MSD antibodies was characterized with biochemical methods. Their ability to stimulate platelets and induce platelet clearance in mice was assessed. Infusion of anti-MSD antibodies does not cause thrombocytopenia in mice. These antibodies show no detectable effects on platelet activation and aggregation in vitro. Further biochemical investigation showed that the anti-MSD antibody 3D1 binds two copies of GPIbα on the platelet surface. Therefore, lateral dimerization of GPIbα induced by antibody binding is not sufficient to initiate GPIb-IX signaling and induce platelet clearance. Our results suggest that a factor other than or in addition to clustering of GPIbα is required to induce platelet clearance. © 2015 International

  1. [Sufficiency with water-soluble vitamins and state of bone in pregnant women].

    Science.gov (United States)

    Vrzhesinskaya, O A; Pereverzeva, O G; Gmoshinskaya, M V; Kodentsova, V M; Safronova, A I; Korosteleva, M M; Aleshina, I V; Fandeeva, T A

    2015-01-01

    Vitamin status and bone strength have been estimated in 91 pregnant women (29.3 ± 4.6 years old) from Moscow by non-invasive methods. Sufficiency with vitamins C, B2, B6 has been evaluated by morning urinary excretion of ascorbic acid, riboflavin and 4-piridoxic acid determined by visual titration and fluorimetric methods. The rate of bone resorption has been measured by the ratio of urinary calcium and creatinine, determined by complexometric titration and spectrophotometrically. The study of the bone strength has been conducted using an ultrasonic densitometer (the speed of the ultrasonic waves along the cortical layer). The lack of vitamin C was found in 20.4% .of the women surveyed, vitamin B2--in 27.4%. Vitamin B6 deficiency was detected most frequently (90%). Excretion of vitamins B2 and B6 in women in the third trimester of pregnancy was lower as compared with the women in the first and second trimester. In 53.3% of the women surveyed an increase in urinary excretion of calcium per creatinine has been observed. Excretion of group B vitamins (especially vitamin B6, 1.75 fold, p vitamin supplements was higher compared to non-taking vitamins that indicates the better sufficiency of the organism with these vitamins. Among women who took vitamin complexes, inadequate supply with water-soluble vitamins C, B2 and B6 was detected less frequently (the difference was significant for vitamin B2) than among women who did not intake vitamin complexes (in 11.9, 27.7 and 42.4% vs 16.1, 54.8 and 48.8 %). The rate of bone resorption (Ca/creatinine) in women taking vitamins was smaller (0.19 ± 0.09 vs 0.24 ± 0.14, p > 0.05). Ca/creatinine ratio was within normal range in 40% of women who intake vitamins, while in women not taking vitamins--only in 22.2%; this value exceeded the upper limit of norm in the rest. The strength of bone was broken in women in the second and third trimester of pregnancy, having worse supply of vitamins. The percentage of agreement of the results

  2. Role of L-alanine for redox self-sufficient amination of alcohols.

    Science.gov (United States)

    Klatte, Stephanie; Wendisch, Volker F

    2015-01-23

    In white biotechnology biocatalysis represents a key technology for chemical functionalization of non-natural compounds. The plasmid-born overproduction of an alcohol dehydrogenase, an L-alanine-dependent transaminase and an alanine dehydrogenase allows for redox self-sufficient amination of alcohols in whole cell biotransformation. Here, conditions to optimize the whole cell biocatalyst presented in (Bioorg Med Chem 22:5578-5585, 2014), and the role of L-alanine for efficient amine functionalization of 1,10-decanediol to 1,10-diaminodecane were analyzed. The enzymes of the cascade for amine functionalization of alcohols were characterized in vitro to find optimal conditions for an efficient process. Transaminase from Chromobacterium violaceum, TaCv, showed three-fold higher catalytic efficiency than transaminase from Vibrio fluvialis, TaVf, and improved production at 37°C. At 42°C, TaCv was more active, which matched thermostable alcohol dehydrogenase and alanine dehydrogenase and improved the 1,10-diaminodecane production rate four-fold. To study the role of L-alanine in the whole cell biotransformation, the L-alanine concentration was varied and 1,10.diaminodecane formation tested with constant 10 mM 1,10- decanediol and 100 mM NH4Cl. Only 5.6% diamine product were observed without added L-alanine. L-alanine concentrations equimolar to that of the alcohol enabled for 94% product formation but higher L-alanine concentrations allowed for 100% product formation. L-alanine was consumed by the E. coli biocatalyst, presumably due to pyruvate catabolism since up to 16 mM acetate accumulated. Biotransformation employing E. coli strain YYC202/pTrc99a-ald-adh-ta Cv, which is unable to catabolize pyruvate, resulted in conversion with a selectivity of 42 mol-%. Biotransformation with E. coli strains only lacking pyruvate oxidase PoxB showed similar reduced amination of 1,10-decanediol indicating that oxidative decarboxylation of pyruvate to acetate by PoxB is primarily

  3. A brief intervention is sufficient for many adolescents seeking help from low threshold adolescent psychiatric services

    Directory of Open Access Journals (Sweden)

    Laukkanen Eila

    2010-09-01

    Full Text Available Abstract Background There has been a considerable increase in the need for psychiatric services for adolescents. Primary health care practitioners have a major role in detecting, screening and helping these adolescents. An intervention entitled SCREEN is described in this article. The SCREEN intervention was developed to help practitioners to detect and screen adolescent needs, to care for adolescents at the primary health care level and to facilitate the referral of adolescents to secondary care services in collaboration between primary and secondary health care. Secondly, the article presents the background and clinical characteristics of youths seeking help from the SCREEN services, and compares the background factors and clinical characteristics of those patients referred and not referred to secondary care services. Methods The SCREEN intervention consisted of 1 to 5 sessions, including assessment by a semi-structured anamnesis interview, the structured Global Assessment Scale, and by a structured priority rating scale, as well as a brief intervention for each adolescent's chosen problem. Parents took part in the assessment in 39% of cases involving girls and 50% involving boys. During 34 months, 2071 adolescents (69% females entered the intervention and 70% completed it. The mean age was 17.1 years for boys and 17.3 years for girls. Results For 69% of adolescents, this was the first contact with psychiatric services. The most common reasons for seeking services were depressive symptoms (31%. Self-harming behaviour had occurred in 25% of girls and 16% of boys. The intervention was sufficient for 37% of those who completed it. Psychosocial functioning improved during the intervention. Factors associated with referral for further treatment were female gender, anxiety as the main complaint, previous psychiatric treatment, self-harming behaviour, a previous need for child welfare services, poor psychosocial functioning and a high score in the

  4. Do invitations for cervical screening provide sufficient information to enable informed choice?

    DEFF Research Database (Denmark)

    Kolthoff, Sie Karen; Hestbech, Mie Sara; Jørgensen, Karsten Juhl

    2016-01-01

    or unmentioned. The same applied to other important harms, such as false-positive results and the psychological consequences from an abnormal test result. The majority of invitations took a paternalistic approach. While only two invitations (17%) included a pre-assigned appointment date, eight (70...

  5. Applied chemical engineering thermodynamics

    CERN Document Server

    Tassios, Dimitrios P

    1993-01-01

    Applied Chemical Engineering Thermodynamics provides the undergraduate and graduate student of chemical engineering with the basic knowledge, the methodology and the references he needs to apply it in industrial practice. Thus, in addition to the classical topics of the laws of thermodynamics,pure component and mixture thermodynamic properties as well as phase and chemical equilibria the reader will find: - history of thermodynamics - energy conservation - internmolecular forces and molecular thermodynamics - cubic equations of state - statistical mechanics. A great number of calculated problems with solutions and an appendix with numerous tables of numbers of practical importance are extremely helpful for applied calculations. The computer programs on the included disk help the student to become familiar with the typical methods used in industry for volumetric and vapor-liquid equilibria calculations.

  6. PSYCHOANALYSIS AS APPLIED AESTHETICS.

    Science.gov (United States)

    Richmond, Stephen H

    2016-07-01

    The question of how to place psychoanalysis in relation to science has been debated since the beginning of psychoanalysis and continues to this day. The author argues that psychoanalysis is best viewed as a form of applied art (also termed applied aesthetics) in parallel to medicine as applied science. This postulate draws on a functional definition of modernity as involving the differentiation of the value spheres of science, art, and religion. The validity criteria for each of the value spheres are discussed. Freud is examined, drawing on Habermas, and seen to have erred by claiming that the psychoanalytic method is a form of science. Implications for clinical and metapsychological issues in psychoanalysis are discussed. © 2016 The Psychoanalytic Quarterly, Inc.

  7. Introduction to applied thermodynamics

    CERN Document Server

    Helsdon, R M; Walker, G E

    1965-01-01

    Introduction to Applied Thermodynamics is an introductory text on applied thermodynamics and covers topics ranging from energy and temperature to reversibility and entropy, the first and second laws of thermodynamics, and the properties of ideal gases. Standard air cycles and the thermodynamic properties of pure substances are also discussed, together with gas compressors, combustion, and psychrometry. This volume is comprised of 16 chapters and begins with an overview of the concept of energy as well as the macroscopic and molecular approaches to thermodynamics. The following chapters focus o

  8. Applying the accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Barbalat, Oscar

    1989-12-15

    Originally developed as tools for frontier physics, particle accelerators provide valuable spinoff benefits in applied research and technology. These accelerator applications are the subject of a biennial meeting in Denton, Texas, but the increasing activity in this field resulted this year (5-9 September) in the first European Conference on Accelerators in Applied Research and Technology, organized by K. Bethge of Frankfurt's Goethe University. The meeting reflected a wide range of applications - ion beam analysis, exploitation of nuclear microbeams, accelerator mass spectrometry, applications of photonuclear reactions, ion beam processing, synchrotron radiation for semiconductor technology, specialized technology.

  9. Applied mathematics made simple

    CERN Document Server

    Murphy, Patrick

    1982-01-01

    Applied Mathematics: Made Simple provides an elementary study of the three main branches of classical applied mathematics: statics, hydrostatics, and dynamics. The book begins with discussion of the concepts of mechanics, parallel forces and rigid bodies, kinematics, motion with uniform acceleration in a straight line, and Newton's law of motion. Separate chapters cover vector algebra and coplanar motion, relative motion, projectiles, friction, and rigid bodies in equilibrium under the action of coplanar forces. The final chapters deal with machines and hydrostatics. The standard and conte

  10. Applying the accelerator

    International Nuclear Information System (INIS)

    Barbalat, Oscar

    1989-01-01

    Originally developed as tools for frontier physics, particle accelerators provide valuable spinoff benefits in applied research and technology. These accelerator applications are the subject of a biennial meeting in Denton, Texas, but the increasing activity in this field resulted this year (5-9 September) in the first European Conference on Accelerators in Applied Research and Technology, organized by K. Bethge of Frankfurt's Goethe University. The meeting reflected a wide range of applications - ion beam analysis, exploitation of nuclear microbeams, accelerator mass spectrometry, applications of photonuclear reactions, ion beam processing, synchrotron radiation for semiconductor technology, specialized technology

  11. On applying cognitive psychology.

    Science.gov (United States)

    Baddeley, Alan

    2013-11-01

    Recent attempts to assess the practical impact of scientific research prompted my own reflections on over 40 years worth of combining basic and applied cognitive psychology. Examples are drawn principally from the study of memory disorders, but also include applications to the assessment of attention, reading, and intelligence. The most striking conclusion concerns the many years it typically takes to go from an initial study, to the final practical outcome. Although the complexity and sheer timescale involved make external evaluation problematic, the combination of practical satisfaction and theoretical stimulation make the attempt to combine basic and applied research very rewarding. © 2013 The British Psychological Society.

  12. A simple threshold rule is sufficient to explain sophisticated collective decision-making.

    Directory of Open Access Journals (Sweden)

    Elva J H Robinson

    Full Text Available Decision-making animals can use slow-but-accurate strategies, such as making multiple comparisons, or opt for simpler, faster strategies to find a 'good enough' option. Social animals make collective decisions about many group behaviours including foraging and migration. The key to the collective choice lies with individual behaviour. We present a case study of a collective decision-making process (house-hunting ants, Temnothorax albipennis, in which a previously proposed decision strategy involved both quality-dependent hesitancy and direct comparisons of nests by scouts. An alternative possible decision strategy is that scouting ants use a very simple quality-dependent threshold rule to decide whether to recruit nest-mates to a new site or search for alternatives. We use analytical and simulation modelling to demonstrate that this simple rule is sufficient to explain empirical patterns from three studies of collective decision-making in ants, and can account parsimoniously for apparent comparison by individuals and apparent hesitancy (recruitment latency effects, when available nests differ strongly in quality. This highlights the need to carefully design experiments to detect individual comparison. We present empirical data strongly suggesting that best-of-n comparison is not used by individual ants, although individual sequential comparisons are not ruled out. However, by using a simple threshold rule, decision-making groups are able to effectively compare options, without relying on any form of direct comparison of alternatives by individuals. This parsimonious mechanism could promote collective rationality in group decision-making.

  13. Oral Administration of Astrovirus Capsid Protein Is Sufficient To Induce Acute Diarrhea In Vivo

    Directory of Open Access Journals (Sweden)

    Victoria A. Meliopoulos

    2016-11-01

    Full Text Available The disease mechanisms associated with the onset of astrovirus diarrhea are unknown. Unlike other enteric virus infections, astrovirus infection is not associated with an inflammatory response or cellular damage. In vitro studies in differentiated Caco-2 cells demonstrated that human astrovirus serotype 1 (HAstV-1 capsid protein alone disrupts the actin cytoskeleton and tight junction complex, leading to increased epithelial barrier permeability. In this study, we show that oral administration of purified recombinant turkey astrovirus 2 (TAstV-2 capsid protein results in acute diarrhea in a dose- and time-dependent manner in turkey poults. Similarly to that induced by infectious virus, TAstV-2 capsid-induced diarrhea was independent of inflammation or histological changes but was associated with increased intestinal barrier permeability, as well as redistribution of sodium hydrogen exchanger 3 (NHE3 from the membrane to the cytoplasm of the intestinal epithelium. Unlike other viral enterotoxins that have been identified, astrovirus capsid induces diarrhea after oral administration, reproducing the natural route of infection and demonstrating that ingestion of intact noninfectious capsid protein may be sufficient to provoke acute diarrhea. Based on these data, we hypothesize that the astrovirus capsid acts like an enterotoxin and induces intestinal epithelial barrier dysfunction.

  14. The N-terminal 33 amino acid domain of Siva-1 is sufficient for nuclear localization

    International Nuclear Information System (INIS)

    Chen, J.Y.; Yang, L.X.; Huang, Z.F.

    2013-01-01

    Siva-1 induces apoptosis in multiple pathological processes and plays an important role in the suppression of tumor metastasis, protein degradation, and other functions. Although many studies have demonstrated that Siva-1 functions in the cytoplasm, a few have found that Siva-1 can relocate to the nucleus. In this study, we found that the first 33 amino acid residues of Siva-1 are required for its nuclear localization. Further study demonstrated that the green fluorescent protein can be imported into the nucleus after fusion with these 33 amino acid residues. Other Siva-1 regions and domains showed less effect on Siva-1 nuclear localization. By site-mutagenesis of all of these 33 amino acid residues, we found that mutants of the first 1-18 amino acids affected Siva-1 nuclear compartmentalization but could not complete this localization independently. In summary, we demonstrated that the N-terminal 33 amino acid residues were sufficient for Siva-1 nuclear localization, but the mechanism of this translocation needs additional investigation

  15. Collaborative technologies, higher order thinking and self-sufficient learning: A case study of adult learners

    Directory of Open Access Journals (Sweden)

    Clare S. Johnson

    2017-07-01

    Full Text Available The inclusion of online elements in learning environments is becoming commonplace in Post Compulsory Education. A variety of research into the value of such elements is available, and this study aims to add further evidence by looking specifically at the use of collaborative technologies such as online discussion forums and wikis to encourage higher order thinking and self-sufficient learning. In particular, the research examines existing pedagogical models including Salmon’s five-stage model, along with other relevant literature. A case study of adult learners in community-based learning centres forms the basis of the research, and as a result of the findings, an arrow model is suggested as a framework for online collaboration that emphasises the learner, mentions pre-course preparation and then includes three main phases of activity: post, interact and critique. This builds on Salmon’s five-stage model and has the benefit of being flexible and responsive, as well as allowing for further development beyond the model, particularly in a blended learning environment.

  16. The N-terminal 33 amino acid domain of Siva-1 is sufficient for nuclear localization

    Energy Technology Data Exchange (ETDEWEB)

    Chen, J.Y.; Yang, L.X. [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou (China); Huang, Z.F. [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou (China); Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou (China); Key Laboratory of Tropical Diseases Control, Sun Yat-sen University, Ministry of Education in China, Guangzhou (China)

    2013-12-02

    Siva-1 induces apoptosis in multiple pathological processes and plays an important role in the suppression of tumor metastasis, protein degradation, and other functions. Although many studies have demonstrated that Siva-1 functions in the cytoplasm, a few have found that Siva-1 can relocate to the nucleus. In this study, we found that the first 33 amino acid residues of Siva-1 are required for its nuclear localization. Further study demonstrated that the green fluorescent protein can be imported into the nucleus after fusion with these 33 amino acid residues. Other Siva-1 regions and domains showed less effect on Siva-1 nuclear localization. By site-mutagenesis of all of these 33 amino acid residues, we found that mutants of the first 1-18 amino acids affected Siva-1 nuclear compartmentalization but could not complete this localization independently. In summary, we demonstrated that the N-terminal 33 amino acid residues were sufficient for Siva-1 nuclear localization, but the mechanism of this translocation needs additional investigation.

  17. Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes.

    Directory of Open Access Journals (Sweden)

    Allison Choyce

    Full Text Available Established cancers are frequently associated with a lymphocytic infiltrate that fails to clear the tumour mass. In contrast, the importance of recruited lymphocytes during premalignancy is less well understood. In a mouse model of premalignant skin epithelium, transgenic mice that express the human papillomavirus type 16 (HPV16 E7 oncoprotein under a keratin 14 promoter (K14E7 mice display epidermal hyperplasia and have a predominant infiltrate of lymphocytes consisting of both CD4 and CD8 T cells. Activated, but not naïve T cells, were shown to preferentially traffic to hyperplastic skin with an increased frequency of proliferative CD8+ T cells and CD4+ T cells expressing CCR6 within the tissue. Disruption of the interaction between E7 protein and retinoblastoma tumour suppressor protein (pRb led to reduced epithelial hyperplasia and T cell infiltrate. Finally, while K14E7 donor skin grafts are readily accepted onto syngeneic, non-transgenic recipients, these same skin grafts lacking skin-resident lymphocytes were rejected. Our data suggests that expression of a single oncoprotein in the epidermis is sufficient for lymphocyte trafficking (including immunosuppressive lymphocytes to premalignant skin.

  18. Sufficient Condition for Estimation in Designing H∞ Filter-Based SLAM

    Directory of Open Access Journals (Sweden)

    Nur Aqilah Othman

    2015-01-01

    Full Text Available Extended Kalman filter (EKF is often employed in determining the position of mobile robot and landmarks in simultaneous localization and mapping (SLAM. Nonetheless, there are some disadvantages of using EKF, namely, the requirement of Gaussian distribution for the state and noises, as well as the fact that it requires the smallest possible initial state covariance. This has led researchers to find alternative ways to mitigate the aforementioned shortcomings. Therefore, this study is conducted to propose an alternative technique by implementing H∞ filter in SLAM instead of EKF. In implementing H∞ filter in SLAM, the parameters of the filter especially γ need to be properly defined to prevent finite escape time problem. Hence, this study proposes a sufficient condition for the estimation purposes. Two distinct cases of initial state covariance are analysed considering an indoor environment to ensure the best solution for SLAM problem exists along with considerations of process and measurement noises statistical behaviour. If the prescribed conditions are not satisfied, then the estimation would exhibit unbounded uncertainties and consequently results in erroneous inference about the robot and landmarks estimation. The simulation results have shown the reliability and consistency as suggested by the theoretical analysis and our previous findings.

  19. The bag-of-frames approach: A not so sufficient model for urban soundscapes

    Science.gov (United States)

    Lagrange, Mathieu; Lafay, Grégoire; Défréville, Boris; Aucouturier, Jean-Julien

    2015-11-01

    The "bag-of-frames" approach (BOF), which encodes audio signals as the long-term statistical distribution of short-term spectral features, is commonly regarded as an effective and sufficient way to represent environmental sound recordings (soundscapes) since its introduction in an influential 2007 article. The present paper describes a concep-tual replication of this seminal article using several new soundscape datasets, with results strongly questioning the adequacy of the BOF approach for the task. We show that the good accuracy originally re-ported with BOF likely result from a particularly thankful dataset with low within-class variability, and that for more realistic datasets, BOF in fact does not perform significantly better than a mere one-point av-erage of the signal's features. Soundscape modeling, therefore, may not be the closed case it was once thought to be. Progress, we ar-gue, could lie in reconsidering the problem of considering individual acoustical events within each soundscape.

  20. Are world uranium resources sufficient to fuel global growth in nuclear generating capacity?

    International Nuclear Information System (INIS)

    Cameron, R.; Vance, R.E.

    2012-01-01

    Increased uranium prices since 2003 have produced more activity in the sector than the previous 20 years. Nuclear reactor construction is proceeding in some countries, ambitious expansion plans have been announced in others and several, particularly in the developing world, are considering introducing nuclear power as a means of meeting rising electricity demand without increasing greenhouse gas emissions. Others have recently decided to either withdraw from the use of nuclear power or not proceed with development plans following the accident at the Fukushima Dai-ichi nuclear power plant in Japan in March 2011. Since the mid-1960, the OECD Nuclear Energy Agency and the International Atomic Energy Agency have jointly prepared a comprehensive update of global uranium resources, production and demand (commonly known as the 'Red Book'. The Red Book is based on government responses to a questionnaire that requests information on uranium exploration and mine development activity, resources and plans for nuclear development to 2035. This presentation provides an overview of the global situation based on the recently published 2011 edition. It features a compilation of global uranium resources, projected mine development and production capability in all the countries currently producing uranium or with plans to do so in the near future. This is compared to updated, post-Fukushima demand projections, reflecting nuclear phase-out plans announced in some countries and ambitious expansion plans of others. The 2011 Red Book shows that currently defined uranium resources are sufficient to meet high case projections of nuclear power development to 2035. (authors)

  1. Necessary and sufficient conditions for big bangs, bounces, crunches, rips, sudden singularities and extremality events

    International Nuclear Information System (INIS)

    Cattoen, Celine; Visser, Matt

    2005-01-01

    Until recently, the physically relevant singularities occurring in FRW cosmologies had traditionally been thought to be limited to the 'big bang', and possibly a 'big crunch'. However, over the last few years, the zoo of cosmological singularities considered in the literature has become considerably more extensive, with 'big rips' and 'sudden singularities' added to the mix, as well as renewed interest in nonsingular cosmological events such as 'bounces' and 'turnarounds'. In this paper we present an extensive catalogue of such cosmological milestones, both at the kinematical and dynamical level. First, using generalized power series, purely kinematical definitions of these cosmological events are provided in terms of the behaviour of the scale factor a(t). The notion of a 'scale-factor singularity' is defined, and its relation to curvature singularities (polynomial and differential) is explored. Second, dynamical information is extracted by using the Friedmann equations (without assuming even the existence of any equation of state) to place constraints on whether or not the classical energy conditions are satisfied at the cosmological milestones. We use these considerations to derive necessary and sufficient conditions for the existence of cosmological milestones such as bangs, bounces, crunches, rips, sudden singularities and extremality events. Since the classification is extremely general and, modulo certain technical assumptions, is complete, the corresponding results are to a high degree model independent: in particular, we provide a characterization of the class of bangs, crunches and sudden singularities for which the dominant energy condition is satisfied

  2. Construction and engineering of a thermostable self-sufficient cytochrome P450

    Energy Technology Data Exchange (ETDEWEB)

    Mandai, Takao; Fujiwara, Shinsuke [Nanobiotechnology Research Center and Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda 669-1337 (Japan); Imaoka, Susumu, E-mail: imaoka@kwansei.ac.jp [Nanobiotechnology Research Center and Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda 669-1337 (Japan)

    2009-06-19

    CYP175A1 is a thermophilic cytochrome P450 and hydroxylates {beta}-carotene. We previously identified a native electron transport system for CYP175A1. In this report, we constructed two fusion proteins consisting of CYP175A1, ferredoxin (Fdx), and ferredoxin-NADP{sup +} reductase (FNR): H{sub 2}N-CYP175A1-Fdx-FNR-COOH (175FR) and H{sub 2}N-CYP175A1-FNR-Fdx-COOH (175RF). Both 175FR and 175RF were expressed in Escherichia coli and purified. The V{sub max} value for {beta}-carotene hydroxylation was 25 times higher with 175RF than 175FR and 9 times higher with 175RF than CYP175A1 (non-fused protein), although the k{sub m} values of these enzymes were similar. 175RF retained 50% residual activity even at 80 {sup o}C. Furthermore, several mutants of the CYP175A1 domain of 175RF were prepared and one mutant (Q67G/Y68I) catalyzed the hydroxylation of an unnatural substrate, testosterone. Thus, this is the first report of a thermostable self-sufficient cytochrome P450 and the engineering of a thermophilic cytochrome P450 for the oxidation of an unnatural substrate.

  3. Overexpression of aromatase alone is sufficient for ovarian development in genetically male chicken embryos.

    Directory of Open Access Journals (Sweden)

    Luke S Lambeth

    Full Text Available Estrogens play a key role in sexual differentiation of both the gonads and external traits in birds. The production of estrogen occurs via a well-characterised steroidogenic pathway, which is a multi-step process involving several enzymes, including cytochrome P450 aromatase. In chicken embryos, the aromatase gene (CYP19A1 is expressed female-specifically from the time of gonadal sex differentiation. To further explore the role of aromatase in sex determination, we ectopically delivered this enzyme using the retroviral vector RCASBP in ovo. Aromatase overexpression in male chicken embryos induced gonadal sex-reversal characterised by an enlargement of the left gonad and development of ovarian structures such as a thickened outer cortex and medulla with lacunae. In addition, the expression of key male gonad developmental genes (DMRT1, SOX9 and Anti-Müllerian hormone (AMH was suppressed, and the distribution of germ cells in sex-reversed males followed the female pattern. The detection of SCP3 protein in late stage sex-reversed male embryonic gonads indicated that these genetically male germ cells had entered meiosis, a process that normally only occurs in female embryonic germ cells. This work shows for the first time that the addition of aromatase into a developing male embryo is sufficient to direct ovarian development, suggesting that male gonads have the complete capacity to develop as ovaries if provided with aromatase.

  4. The case for neuropsychoanalysis: Why a dialogue with neuroscience is necessary but not sufficient for psychoanalysis.

    Science.gov (United States)

    Yovell, Yoram; Solms, Mark; Fotopoulou, Aikaterini

    2015-12-01

    Recent advances in the cognitive, affective and social neurosciences have enabled these fields to study aspects of the mind that are central to psychoanalysis. These developments raise a number of possibilities for psychoanalysis. Can it engage the neurosciences in a productive and mutually enriching dialogue without compromising its own integrity and unique perspective? While many analysts welcome interdisciplinary exchanges with the neurosciences, termed neuropsychoanalysis, some have voiced concerns about their potentially deleterious effects on psychoanalytic theory and practice. In this paper we outline the development and aims of neuropsychoanalysis, and consider its reception in psychoanalysis and in the neurosciences. We then discuss some of the concerns raised within psychoanalysis, with particular emphasis on the epistemological foundations of neuropsychoanalysis. While this paper does not attempt to fully address the clinical applications of neuropsychoanalysis, we offer and discuss a brief case illustration in order to demonstrate that neuroscientific research findings can be used to enrich our models of the mind in ways that, in turn, may influence how analysts work with their patients. We will conclude that neuropsychoanalysis is grounded in the history of psychoanalysis, that it is part of the psychoanalytic worldview, and that it is necessary, albeit not sufficient, for the future viability of psychoanalysis. Copyright © 2015 Institute of Psychoanalysis.

  5. Low ATP level is sufficient to maintain the uncommitted state of multipotent mesenchymal stem cells.

    Science.gov (United States)

    Buravkova, L B; Rylova, Y V; Andreeva, E R; Kulikov, A V; Pogodina, M V; Zhivotovsky, B; Gogvadze, V

    2013-10-01

    Multipotent mesenchymal stromal cells (MMSCs) are minimally differentiated precursors with great potential to transdifferentiate. These cells are quite resistant to oxygen limitation, suggesting that a hypoxic milieu can be physiological for MMSCs. Human MMSCs isolated from adipose tissue were grown at various oxygen concentrations. Alteration in cell immunophenotype was determined by flow cytometry after staining with specific antibodies. Concentrations of glucose and lactate were determined using the Biocon colorimetric test. Cellular respiration was assessed using oxygen electrode. The modes of cell death were analyzed by flow cytometry after staining with Annexin V and propidium iodide. We found that permanent oxygen deprivation attenuated cellular ATP levels in these cells, diminishing mitochondrial ATP production but stimulating glycolytic ATP production. At the same time, permanent hypoxia did not affect MMSCs' viability, stimulated their proliferation and reduced their capacity to differentiate. Further, permanent hypoxia decreased spontaneous cell death by MMSCs. Under hypoxic conditions glycolysis provides sufficient energy to maintain MMSCs in an uncommitted state. These findings are of interest not only for scientific reasons, but also in practical terms. Oxygen concentration makes an essential contribution to MMSC physiology and should be taken into account in the setting of protocols for cellular therapy. Copyright © 2013 Elsevier B.V. All rights reserved.

  6. A sufficient condition for de Sitter vacua in type IIB string theory

    Energy Technology Data Exchange (ETDEWEB)

    Rummel, Markus [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Westphal, Alexander [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2011-07-15

    We derive a sufficient condition for realizing meta-stable de Sitter vacua with small positive cosmological constant within type IIB string theory flux compactifications with spontaneously broken supersymmetry. There are a number of 'lamp post' constructions of de Sitter vacua in type IIB string theory and supergravity. We show that one of them - the method of 'Kaehler uplifting' by F-terms from an interplay between non-perturbative effects and the leading {alpha}'-correction - allows for a more general parametric understanding of the existence of de Sitter vacua. The result is a condition on the values of the flux induced superpotential and the topological data of the Calabi-Yau compactification, which guarantees the existence of a meta-stable de Sitter vacuum if met. Our analysis explicitly includes the stabilization of all moduli, i.e. the Kaehler, dilaton and complex structure moduli, by the interplay of the leading perturbative and non-perturbative effects at parametrically large volume. (orig.)

  7. Construction and engineering of a thermostable self-sufficient cytochrome P450

    International Nuclear Information System (INIS)

    Mandai, Takao; Fujiwara, Shinsuke; Imaoka, Susumu

    2009-01-01

    CYP175A1 is a thermophilic cytochrome P450 and hydroxylates β-carotene. We previously identified a native electron transport system for CYP175A1. In this report, we constructed two fusion proteins consisting of CYP175A1, ferredoxin (Fdx), and ferredoxin-NADP + reductase (FNR): H 2 N-CYP175A1-Fdx-FNR-COOH (175FR) and H 2 N-CYP175A1-FNR-Fdx-COOH (175RF). Both 175FR and 175RF were expressed in Escherichia coli and purified. The V max value for β-carotene hydroxylation was 25 times higher with 175RF than 175FR and 9 times higher with 175RF than CYP175A1 (non-fused protein), although the k m values of these enzymes were similar. 175RF retained 50% residual activity even at 80 o C. Furthermore, several mutants of the CYP175A1 domain of 175RF were prepared and one mutant (Q67G/Y68I) catalyzed the hydroxylation of an unnatural substrate, testosterone. Thus, this is the first report of a thermostable self-sufficient cytochrome P450 and the engineering of a thermophilic cytochrome P450 for the oxidation of an unnatural substrate.

  8. MARKET SUPPLY RESPONSE AND DEMAND FOR LOCAL RICE IN NIGERIA: IMPLICATIONS FOR SELF-SUFFICIENCY POLICY

    Directory of Open Access Journals (Sweden)

    M RAHJI

    2009-03-01

    Full Text Available This study examined the supply response and demand for local rice in Nigeria between 1960 and 2004. A system of equations using secondary data was estimated by OLS and 2SLS techniques. Area planted with local rice is mainly affected by expected price of output, agriculture wage rate and by the partial adjustment coefficient. The short-run response elasticity is 0.077. The implied long-run response elasticity is 1.578. The partial adjustment measure is 0.049. This, points to the difficulty of supply response to changing economic conditions. The price elasticity of demand obtained is 0.841. The demand for local rice is thus price inelastic. Rice income elasticity is 0.3378. It is also inelastic. The ban on rice importation in Nigeria could be said to be a step in the right direction. This policy should be continued and policed. However, price, output and non-price incentives that can exert significant influence on rice supply response and demand are required if the self-sufficiency goal is to be achieved.

  9. Non-Ligand-Induced Dimerization is Sufficient to Initiate the Signalling and Endocytosis of EGF Receptor

    Directory of Open Access Journals (Sweden)

    George Kourouniotis

    2016-07-01

    Full Text Available The binding of epidermal growth factor (EGF to EGF receptor (EGFR stimulates cell mitogenesis and survival through various signalling cascades. EGF also stimulates rapid EGFR endocytosis and its eventual degradation in lysosomes. The immediate events induced by ligand binding include receptor dimerization, activation of intrinsic tyrosine kinase and autophosphorylation. However, in spite of intensified efforts, the results regarding the roles of these events in EGFR signalling and internalization is still very controversial. In this study, we constructed a chimeric EGFR by replacing its extracellular domain with leucine zipper (LZ and tagged a green fluorescent protein (GFP at its C-terminus. We showed that the chimeric LZ-EGFR-GFP was constitutively dimerized. The LZ-EGFR-GFP dimer autophosphorylated each of its five well-defined C-terminal tyrosine residues as the ligand-induced EGFR dimer does. Phosphorylated LZ-EGFR-GFP was localized to both the plasma membrane and endosomes, suggesting it is capable of endocytosis. We also showed that LZ-EGFR-GFP activated major signalling proteins including Src homology collagen-like (Shc, extracellular signal-regulated kinase (ERK and Akt. Moreover, LZ-EGFR-GFP was able to stimulate cell proliferation. These results indicate that non-ligand induced dimerization is sufficient to activate EGFR and initiate cell signalling and EGFR endocytosis. We conclude that receptor dimerization is a critical event in EGF-induced cell signalling and EGFR endocytosis.

  10. On the enduring and substantial influence of Carl Rogers' not-quite necessary nor sufficient conditions.

    Science.gov (United States)

    Farber, Barry A

    2007-09-01

    Carl Rogers' 1957 paper (see record 2007-14639-002) is arguably the most successful of his many attempts to clarify and render testable the ideas behind client-centered therapy. While each of the conditions that Rogers postulated has been linked to positive therapeutic outcome, taken together they have never been conclusively proved (nor disproved) to be either necessary or sufficient for positive outcome. Nevertheless, the overriding "take-home" message in this classic paper--that the therapist's attitude and caring presence is critical for therapeutic success--is one that has had virtually unparalleled influence in every segment of the psychotherapeutic community. Clinical and theoretical innovations in the psychoanalytic community serve as examples of the following proposition: that Rogers' concepts, while accepted more than ever by a remarkably wide variety of psychotherapists, remain essentially unacknowledged as originating with him or in the tradition of humanistic and client-centered therapy. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

  11. Spirituality, hope, and self-sufficiency among low-income job seekers.

    Science.gov (United States)

    2015-04-01

    Self-sufficiency (SS) is an important social welfare policy goal in the United States, yet little is known about the process that leads to SS. To address this gap in the literature, this study examined the relationship between spirituality, hope, and SS among a sample of low-income job seekers (N = 116). It was hypothesized that spirituality would be related to hope, and that hope, in turn, would be related to SS. Using survey data from two workforce development agencies, this hypothesis was confirmed-hope fully mediated the relationship between spirituality and SS. Of the two factors through which hope is commonly operationalized-agency and pathways-supplemental analysis suggested that spirituality only affects SS through the agency channel. To help foster hope in direct practice settings, it is suggested that social workers might employ spiritually modified cognitive-behavioral therapy protocols. Macrostructural interventions that block the pathway component of hope are also suggested to help reverse exclusion from labor market entry. As such, hope needs to be addressed comprehensively-intrapsychically and macrostructurally-to effect bottom-up change for SS. Engendering hope may assist clients overcome some of the many challenges they encounter on the journey to SS.

  12. Navigation and history of science: autopsy to submarine Kursk. Survival previsions were not sufficient

    Directory of Open Access Journals (Sweden)

    Ignacio Jáuregui-Lobera

    2018-01-01

    Full Text Available On August 12, 2000, Saturday, a Russian submarine of the Oscar II class, the K-141 Kursk, sank in the Barents Sea, while sailing as part of the "Summer-X Exercise" manoeuvres. The Kursk was a giant double-hulled submarine, with nine sealed compartments, considered impossible to be sunk. During the manoeuvres, at 08:51 local time, the Kursk requested permission to prepare a torpedo and it received the response "Dobro" (good in English. At 11:29:34 (07:29:50 UTC the Norwegian seismic monitoring network (NORSAR registered an earthquake of intensity 1.5 on the Richter scale at northeast of Murmansk, approximately 250 Km from Norway, and 80 Km from the Kola Peninsula. At 11:31:48, two minutes and fourteen seconds later, a second movement, 4.2 on the Richter scale and 250 times longer than the first, was recorded by different seismographs, even being detected in Alaska. It was equivalent to an explosion of 2-3 Tm of TNT. After a great confusion and propaganda, there was no choice other than to accept the facts: the Kursk had suffered two explosions, had sunk and the whole crew had perished. But what happened in that submarine? It seems clear that survival previsions were not sufficient.

  13. Protein Kinase-A Inhibition Is Sufficient to Support Human Neural Stem Cells Self-Renewal.

    Science.gov (United States)

    Georges, Pauline; Boissart, Claire; Poulet, Aurélie; Peschanski, Marc; Benchoua, Alexandra

    2015-12-01

    Human pluripotent stem cell-derived neural stem cells offer unprecedented opportunities for producing specific types of neurons for several biomedical applications. However, to achieve it, protocols of production and amplification of human neural stem cells need to be standardized, cost effective, and safe. This means that small molecules should progressively replace the use of media containing cocktails of protein-based growth factors. Here we have conducted a phenotypical screening to identify pathways involved in the regulation of hNSC self-renewal. We analyzed 80 small molecules acting as kinase inhibitors and identified compounds of the 5-isoquinolinesulfonamide family, described as protein kinase A (PKA) and protein kinase G inhibitors, as candidates to support hNSC self-renewal. Investigating the mode of action of these compounds, we found that modulation of PKA activity was central in controlling the choice between self-renewal or terminal neuronal differentiation of hNSC. We finally demonstrated that the pharmacological inhibition of PKA using the small molecule HA1004 was sufficient to support the full derivation, propagation, and long-term maintenance of stable hNSC in absence of any other extrinsic signals. Our results indicated that tuning of PKA activity is a core mechanism regulating hNSC self-renewal and differentiation and delineate the minimal culture media requirement to maintain undifferentiated hNSC in vitro. © 2015 AlphaMed Press.

  14. Necessary and sufficient conditions for non-perturbative equivalences of large Nc orbifold gauge theories

    International Nuclear Information System (INIS)

    Kovtun, Pave; Uensal, Mithat; Yaffe, Laurence G.

    2005-01-01

    Large N coherent state methods are used to study the relation between U(N c ) gauge theories containing adjoint representation matter fields and their orbifold projections. The classical dynamical systems which reproduce the large N c limits of the quantum dynamics in parent and daughter orbifold theories are compared. We demonstrate that the large N c dynamics of the parent theory, restricted to the subspace invariant under the orbifold projection symmetry, and the large N c dynamics of the daughter theory, restricted to the untwisted sector invariant under 'theory space' permutations, coincide. This implies equality, in the large N c limit, between appropriately identified connected correlation functions in parent and daughter theories, provided the orbifold projection symmetry is not spontaneously broken in the parent theory and the theory space permutation symmetry is not spontaneously broken in the daughter. The necessity of these symmetry realization conditions for the validity of the large N c equivalence is unsurprising, but demonstrating the sufficiency of these conditions is new. This work extends an earlier proof of non-perturbative large N c equivalence which was only valid in the phase of the (lattice regularized) theories continuously connected to large mass and strong coupling

  15. Necessary and Sufficient Standards Closure Process pilot: F- and H-Area groundwater remediation

    International Nuclear Information System (INIS)

    Bullington, M.

    1995-01-01

    The DOE Standards Committee's Necessary and Sufficient (N and S) Standards Closure Process was piloted at SRS on the F- and H- Area Seepage Basins Groundwater Remediation Project. For this existing Environmental Restoration project, the set of N and S standards for design and safety documentation were identified, independently confirmed and approved. Implementation of these standards on the project can lead to a $2.8 Million cost savings on the design, construction/installation, and safety documentation scope of $18 Million. These savings were primarily from site design of power distribution and piping for the water treatment units. Also contributing to the savings were a more appropriate level of safety documentation and the alternate ''commercial'' bids made by vendors in response to a request for proposals for water treatment units. The use of the N and S Process on an ER activity, details on the cost savings, lessons learned and recommendations for broader implementation of the N and S Process are described herein

  16. A simple threshold rule is sufficient to explain sophisticated collective decision-making.

    Science.gov (United States)

    Robinson, Elva J H; Franks, Nigel R; Ellis, Samuel; Okuda, Saki; Marshall, James A R

    2011-01-01

    Decision-making animals can use slow-but-accurate strategies, such as making multiple comparisons, or opt for simpler, faster strategies to find a 'good enough' option. Social animals make collective decisions about many group behaviours including foraging and migration. The key to the collective choice lies with individual behaviour. We present a case study of a collective decision-making process (house-hunting ants, Temnothorax albipennis), in which a previously proposed decision strategy involved both quality-dependent hesitancy and direct comparisons of nests by scouts. An alternative possible decision strategy is that scouting ants use a very simple quality-dependent threshold rule to decide whether to recruit nest-mates to a new site or search for alternatives. We use analytical and simulation modelling to demonstrate that this simple rule is sufficient to explain empirical patterns from three studies of collective decision-making in ants, and can account parsimoniously for apparent comparison by individuals and apparent hesitancy (recruitment latency) effects, when available nests differ strongly in quality. This highlights the need to carefully design experiments to detect individual comparison. We present empirical data strongly suggesting that best-of-n comparison is not used by individual ants, although individual sequential comparisons are not ruled out. However, by using a simple threshold rule, decision-making groups are able to effectively compare options, without relying on any form of direct comparison of alternatives by individuals. This parsimonious mechanism could promote collective rationality in group decision-making.

  17. Health-Related Fitness and Young Children.

    Science.gov (United States)

    Gabbard, Carl; LeBlanc, Betty

    Because research indicates that American youth have become fatter since the 1960's, the development of fitness among young children should not be left to chance. Simple games, rhythms, and dance are not sufficient to insure fitness, for, during the regular free play situation, children very seldom experience physical activity of enough intensity…

  18. Advances in applied mechanics

    CERN Document Server

    Wu, Theodore Y; Wu, Theodore Y

    2000-01-01

    This highly acclaimed series provides survey articles on the present state and future direction of research in important branches of applied solid and fluid mechanics. Mechanics is defined as a branch of physics that focuses on motion and on the reaction of physical systems to internal and external forces.

  19. Signals: Applying Academic Analytics

    Science.gov (United States)

    Arnold, Kimberly E.

    2010-01-01

    Academic analytics helps address the public's desire for institutional accountability with regard to student success, given the widespread concern over the cost of higher education and the difficult economic and budgetary conditions prevailing worldwide. Purdue University's Signals project applies the principles of analytics widely used in…

  20. Journal of Applied Biosciences

    African Journals Online (AJOL)

    The Journal of Applied Biosciences provides a forum for scholars and practitioners in all spheres of biological sciences to publish their research findings or theoretical concepts and ideas of a scientific nature. Other websites related to this journal: http://m.elewa.org/Journals/about-jab/ ...

  1. Thermodynamics applied. Where? Why?

    NARCIS (Netherlands)

    Hirs, Gerard

    2003-01-01

    In recent years, thermodynamics has been applied in a number of new fields leading to a greater societal impact. This paper gives a survey of these new fields and the reasons why these applications are important. In addition, it is shown that the number of fields could be even greater in the future

  2. Thermodynamics, applied. : Where? why?

    NARCIS (Netherlands)

    Hirs, Gerard

    1999-01-01

    In recent years thermodynamics has been applied in a number of new fields leading to a greater societal impact. The paper gives a survey of these new fields and the reasons why these applications are important. In addition it is shown that the number of fields could be even greater in the future and

  3. Applied Statistics with SPSS

    Science.gov (United States)

    Huizingh, Eelko K. R. E.

    2007-01-01

    Accessibly written and easy to use, "Applied Statistics Using SPSS" is an all-in-one self-study guide to SPSS and do-it-yourself guide to statistics. What is unique about Eelko Huizingh's approach is that this book is based around the needs of undergraduate students embarking on their own research project, and its self-help style is designed to…

  4. Applied research on glucansucrases

    Science.gov (United States)

    Although glycansucrases have been known for over 70 years, they remain relatively unknown except to a small group of researchers. Practical, applied research on glycansucrases has been focused on certain key areas. The earliest of these was the development of blood plasma extenders from dextran, d...

  5. Essays in applied microeconometrics

    NARCIS (Netherlands)

    Cervený, Jakub

    2017-01-01

    Duration analysis has been widely used in the applied economic research since the late 1970s. The framework allows to examine the duration of time intervals and the rate of transition across a set of states over time. Many economic behaviors follow a similar pattern, such as transition from the

  6. Applied Linguistics in Europe

    NARCIS (Netherlands)

    de Bot, Kees

    2004-01-01

    In this contribution developments in Applied Linguistics in Europe are linked to major social changes that have taken place over the last decades. These include: The decline of the USSR and the end of the cold war; The development of the EEC and the EU and fading of borders; The economic growth of

  7. Applied Anthropology in Broadcasting

    Science.gov (United States)

    Eiselein, E. B.

    1976-01-01

    Three different applied media anthropology projects are described. These projects stem from the broadcasters' legal need to know about the community (community ascertainment), the broadcasters' need to know about the station audience (audience profile), and the broadcasters' desire to change a community (action projects). (Author)

  8. Counterforce applied to prevent spalling

    International Nuclear Information System (INIS)

    Glamheden, Rune; Bergkvist, Lars; Faelth, Billy; Jacobsson, Lars; Harrstroem, Johan; Berglund, Johan

    2010-04-01

    The field experiment within CAPS (Counterforce Applied to Prevent Spalling) was initiated to determine if the application of dry bentonite pellets is sufficient to suppress thermally-induced spalling in KBS-3 deposition holes. The experience gained from Aespoe Pillar Stability Experiment, conducted between 2002 and 2006, indicated that spalling could be controlled by the application of a small confining pressure in the deposition holes. The CAPS field experiment that included four pairs of boreholes with a diameter of approximately 0.5 m, was carried out as a series of demonstration experiments in the TASQ-tunnel. The first and second heating tests were performed in open holes, without any confining pressure on the borehole wall and the third and fourth heating tests with a confining pressure created by expanded clay pellets (LECA). The first heating test was initiated at the end of August 2008 and the final test was finished at the end of May 2009. The trials suggest that the small confining pressure offered by the LECA pellets was adequate to control spalling and prevent the formation of a highly conductive zone of fractured rock in the 500-mm-diameter holes. It is recommended that a full-scale test be carried out to assess if the findings are applicable to 1,750-mm-diameter deposition holes. Should the full scale tests support the findings from these initial trials, filling the gap between the bentonite blocks and rock wall with dry bentonite pellets will provide a viable engineered solution for controlling the effects of thermally induced spalling in the KBS-3 deposition holes

  9. Counterforce applied to prevent spalling

    Energy Technology Data Exchange (ETDEWEB)

    Glamheden, Rune; Bergkvist, Lars (Golder Associates AB (Sweden)); Faelth, Billy (Clay Technology AB, Lund (Sweden)); Jacobsson, Lars (SP Technical Research Institute of Sweden, Boraas (Sweden)); Harrstroem, Johan (Geosigma AB, Uppsala (Sweden)); Berglund, Johan (Vattenfall Power Consultant AB, Stockholm (Sweden))

    2010-04-15

    The field experiment within CAPS (Counterforce Applied to Prevent Spalling) was initiated to determine if the application of dry bentonite pellets is sufficient to suppress thermally-induced spalling in KBS-3 deposition holes. The experience gained from Aespoe Pillar Stability Experiment, conducted between 2002 and 2006, indicated that spalling could be controlled by the application of a small confining pressure in the deposition holes. The CAPS field experiment that included four pairs of boreholes with a diameter of approximately 0.5 m, was carried out as a series of demonstration experiments in the TASQ-tunnel. The first and second heating tests were performed in open holes, without any confining pressure on the borehole wall and the third and fourth heating tests with a confining pressure created by expanded clay pellets (LECA). The first heating test was initiated at the end of August 2008 and the final test was finished at the end of May 2009. The trials suggest that the small confining pressure offered by the LECA pellets was adequate to control spalling and prevent the formation of a highly conductive zone of fractured rock in the 500-mm-diameter holes. It is recommended that a full-scale test be carried out to assess if the findings are applicable to 1,750-mm-diameter deposition holes. Should the full scale tests support the findings from these initial trials, filling the gap between the bentonite blocks and rock wall with dry bentonite pellets will provide a viable engineered solution for controlling the effects of thermally induced spalling in the KBS-3 deposition holes

  10. Emergency management: does it have a sufficiently comprehensive understanding of decision-making, process and context?

    International Nuclear Information System (INIS)

    Niculae, C.

    2003-01-01

    Full text: It is now widely recognized in the social and management sciences that the effective support of decision-making requires a multi-disciplinary perspective, with businesses increasingly using inter-disciplinary teams. This trend is also seen in nuclear emergency management, for example in the UK inter-disciplinary groups are formed to focus on specific topics such as remediation where their recommendations are feed to the decision makers. The necessity of taking a multi-disciplinary perspective is particularly important for contexts in which the decision makers are likely to be under high stress and so could revert to instinctive patterns of behaviour and modes of communication found in their core disciplines. Yet when we look at the design of the information systems produced to support emergency management, we find a very partial set of disciplinary perspectives providing a strongly rationalistic, technocratic view. These systems have been developed by the technical community with little consultation with non-expert decision makers and limited understanding of emergency management processes across Europe and the social systems with which they interact. In this paper we have considered the Cynefin model, developed by IBM, which draws together much of the work on decision making and decision context over the past 30-40 years, describing the possible contexts in which decision-making may take place, the known, the knowable, the complex and the chaotic space. The known space is the realm of scientific knowledge where the cause and effect are understood. Next, there is the knowable space the realm of scientific enquiry where the cause and effect can be determined with sufficient data. In the complex space there are many interacting cause and effects, to the extent that we do not have sufficiently refined models to predict what will happen as a consequence of any particular actions and the cause and effect may only be explained after the event. In the chaotic

  11. Profitability analysis of grid-connected photovoltaic facilities for household electricity self-sufficiency

    International Nuclear Information System (INIS)

    Colmenar-Santos, Antonio; Campíñez-Romero, Severo; Pérez-Molina, Clara; Castro-Gil, Manuel

    2012-01-01

    Spain exhibits a high level of energy dependence and has significant solar energy resources. These two facts have given rise to the prominence that renewable energy, particularly solar photovoltaic technology, has enjoyed in recent years, supported by a favorable regulatory framework. Currently, the Spanish Government is providing new ways in energy policy to enhance and accelerate the development of low-power photovoltaic generation facilities for self-consumption by introducing energy policies for feed-in payments of surplus electricity. Such facilities are an example of distributed electrical generation with important benefits for the environment and the rest of the electrical system because, when properly managed, they can help improve the system’s stability and reduce overall losses. By analyzing household demand and solar photovoltaic energy resources, the profitability of such facilities is considered in this article, taking into account the technical and economic impact of storage systems and proposing models for feed-in payments of surplus electricity, in an attempt to assess whether this method of electricity generation versus the method of conventionally supplied power from a grid at a regulated tariff can rival each other economically, in terms of parity. - Highlight: ► The use of grid-connected photovoltaic facilities for household electricity self-sufficiency is presented. ► The need for legal frameworks that include retributive mechanisms for the surplus energy is pointed out. ► Two models are proposed for the remuneration of surplus energy generated. ► Models show economic profitability without feed-in-tariff or compensations. ► Facilities described offer ancillary services for grid stability and smart-grid integration.

  12. The Ebola Virus Glycoprotein Contributes to but Is Not Sufficient for Virulence In Vivo

    Science.gov (United States)

    Groseth, Allison; Marzi, Andrea; Hoenen, Thomas; Herwig, Astrid; Gardner, Don; Becker, Stephan; Ebihara, Hideki; Feldmann, Heinz

    2012-01-01

    Among the Ebola viruses most species cause severe hemorrhagic fever in humans; however, Reston ebolavirus (REBOV) has not been associated with human disease despite numerous documented infections. While the molecular basis for this difference remains unclear, in vitro evidence has suggested a role for the glycoprotein (GP) as a major filovirus pathogenicity factor, but direct evidence for such a role in the context of virus infection has been notably lacking. In order to assess the role of GP in EBOV virulence, we have developed a novel reverse genetics system for REBOV, which we report here. Together with a previously published full-length clone for Zaire ebolavirus (ZEBOV), this provides a unique possibility to directly investigate the role of an entire filovirus protein in pathogenesis. To this end we have generated recombinant ZEBOV (rZEBOV) and REBOV (rREBOV), as well as chimeric viruses in which the glycoproteins from these two virus species have been exchanged (rZEBOV-RGP and rREBOV-ZGP). All of these viruses could be rescued and the chimeras replicated with kinetics similar to their parent virus in tissue culture, indicating that the exchange of GP in these chimeric viruses is well tolerated. However, in a mouse model of infection rZEBOV-RGP demonstrated markedly decreased lethality and prolonged time to death when compared to rZEBOV, confirming that GP does indeed contribute to the full expression of virulence by ZEBOV. In contrast, rREBOV-ZGP did not show any signs of virulence, and was in fact slightly attenuated compared to rREBOV, demonstrating that GP alone is not sufficient to confer a lethal phenotype or exacerbate disease in this model. Thus, while these findings provide direct evidence that GP contributes to filovirus virulence in vivo, they also clearly indicate that other factors are needed for the acquisition of full virulence. PMID:22876185

  13. Boosting long-term memory via wakeful rest: intentional rehearsal is not necessary, consolidation is sufficient.

    Science.gov (United States)

    Dewar, Michaela; Alber, Jessica; Cowan, Nelson; Della Sala, Sergio

    2014-01-01

    People perform better on tests of delayed free recall if learning is followed immediately by a short wakeful rest than by a short period of sensory stimulation. Animal and human work suggests that wakeful resting provides optimal conditions for the consolidation of recently acquired memories. However, an alternative account cannot be ruled out, namely that wakeful resting provides optimal conditions for intentional rehearsal of recently acquired memories, thus driving superior memory. Here we utilised non-recallable words to examine whether wakeful rest boosts long-term memory, even when new memories could not be rehearsed intentionally during the wakeful rest delay. The probing of non-recallable words requires a recognition paradigm. Therefore, we first established, via Experiment 1, that the rest-induced boost in memory observed via free recall can be replicated in a recognition paradigm, using concrete nouns. In Experiment 2, participants heard 30 non-recallable non-words, presented as 'foreign names in a bridge club abroad' and then either rested wakefully or played a visual spot-the-difference game for 10 minutes. Retention was probed via recognition at two time points, 15 minutes and 7 days after presentation. As in Experiment 1, wakeful rest boosted recognition significantly, and this boost was maintained for at least 7 days. Our results indicate that the enhancement of memory via wakeful rest is not dependent upon intentional rehearsal of learned material during the rest period. We thus conclude that consolidation is sufficient for this rest-induced memory boost to emerge. We propose that wakeful resting allows for superior memory consolidation, resulting in stronger and/or more veridical representations of experienced events which can be detected via tests of free recall and recognition.

  14. Is LMWH Sufficient for Anticoagulant Prophylaxis in Bariatric Surgery? Prospective Study.

    Science.gov (United States)

    Moaad, Farraj; Zakhar, Bramnik; Anton, Kvasha; Moner, Merie; Wisam, Sbeit; Safy, Farraj; Igor, Waksman

    2017-09-01

    The objective of this study was to evaluate the coagulation profile by thromboelastography in morbidly obese patients who undergo bariatric surgery. Morbid obesity entails increased risk for thromboembolic events. There is no clear protocol for thromboembolic prophylaxis, regarding timing and length of treatment, in bariatric surgery. Thromboelastography provides data on a coagulation process from creation of the clot until the fibrinolysis. Ninety-three morbidly obese patients were prospectively recruited within a 2-year period. Coagulation profile was measured by thromboelastography before surgery, in the immediate postoperative period, within 3 h from surgery, and in the late postoperative period, within 10-14 days after surgery. Venous thromboembolic prophylaxis was achieved by giving low molecular weight heparin (LMWH), once a day. Of the eligible patients, 67 underwent sleeve gastrectomy while 23 underwent Roux-en-Y gastric bypass. Normal values of coagulation factor function, clotting time, and fibrin function, as measured by R, K, and α (angle), were demonstrated in addition to higher maximal amplitude (MA) values, reflecting increased function of platelets. The average MA value before the surgery was above normal and continued rising consistently in the immediate postoperative as well as in the early postoperative period. Morbidly obese patients have a strong tendency toward thrombosis, as demonstrated by pathologically elevated MA values. Altered coagulation profiles were demonstrated 2 weeks postoperatively; thus, prophylaxis that continued at least for 2 weeks after bariatric surgery should be considered. Since LMW heparin is not sufficient alone as thromboembolic prophylaxis, we recommend adding antiplatelet therapy. Further evaluation of appropriate thromboprophylaxis is warranted.

  15. GATA4 Is Sufficient to Establish Jejunal Versus Ileal Identity in the Small IntestineSummary

    Directory of Open Access Journals (Sweden)

    Cayla A. Thompson

    2017-05-01

    Full Text Available Background & Aims: Patterning of the small intestinal epithelium along its cephalocaudal axis establishes three functionally distinct regions: duodenum, jejunum, and ileum. Efficient nutrient assimilation and growth depend on the proper spatial patterning of specialized digestive and absorptive functions performed by duodenal, jejunal, and ileal enterocytes. When enterocyte function is disrupted by disease or injury, intestinal failure can occur. One approach to alleviate intestinal failure would be to restore lost enterocyte functions. The molecular mechanisms determining regionally defined enterocyte functions, however, are poorly delineated. We previously showed that GATA binding protein 4 (GATA4 is essential to define jejunal enterocytes. The goal of this study was to test the hypothesis that GATA4 is sufficient to confer jejunal identity within the intestinal epithelium. Methods: To test this hypothesis, we generated a novel Gata4 conditional knock-in mouse line and expressed GATA4 in the ileum, where it is absent. Results: We found that GATA4-expressing ileum lost ileal identity. The global gene expression profile of GATA4-expressing ileal epithelium aligned more closely with jejunum and duodenum rather than ileum. Focusing on jejunal vs ileal identity, we defined sets of jejunal and ileal genes likely to be regulated directly by GATA4 to suppress ileal identity and promote jejunal identity. Furthermore, our study implicates GATA4 as a transcriptional repressor of fibroblast growth factor 15 (Fgf15, which encodes an enterokine that has been implicated in an increasing number of human diseases. Conclusions: Overall, this study refines our understanding of an important GATA4-dependent molecular mechanism to pattern the intestinal epithelium along its cephalocaudal axis by elaborating on GATA4’s function as a crucial dominant molecular determinant of jejunal enterocyte identity. Microarray data from this study have been deposited into

  16. Boosting long-term memory via wakeful rest: intentional rehearsal is not necessary, consolidation is sufficient.

    Directory of Open Access Journals (Sweden)

    Michaela Dewar

    Full Text Available People perform better on tests of delayed free recall if learning is followed immediately by a short wakeful rest than by a short period of sensory stimulation. Animal and human work suggests that wakeful resting provides optimal conditions for the consolidation of recently acquired memories. However, an alternative account cannot be ruled out, namely that wakeful resting provides optimal conditions for intentional rehearsal of recently acquired memories, thus driving superior memory. Here we utilised non-recallable words to examine whether wakeful rest boosts long-term memory, even when new memories could not be rehearsed intentionally during the wakeful rest delay. The probing of non-recallable words requires a recognition paradigm. Therefore, we first established, via Experiment 1, that the rest-induced boost in memory observed via free recall can be replicated in a recognition paradigm, using concrete nouns. In Experiment 2, participants heard 30 non-recallable non-words, presented as 'foreign names in a bridge club abroad' and then either rested wakefully or played a visual spot-the-difference game for 10 minutes. Retention was probed via recognition at two time points, 15 minutes and 7 days after presentation. As in Experiment 1, wakeful rest boosted recognition significantly, and this boost was maintained for at least 7 days. Our results indicate that the enhancement of memory via wakeful rest is not dependent upon intentional rehearsal of learned material during the rest period. We thus conclude that consolidation is sufficient for this rest-induced memory boost to emerge. We propose that wakeful resting allows for superior memory consolidation, resulting in stronger and/or more veridical representations of experienced events which can be detected via tests of free recall and recognition.

  17. Analyzing components of Community Reinforcement and Family Training (CRAFT): Is treatment entry training sufficient?

    Science.gov (United States)

    Kirby, Kimberly C; Benishek, Lois A; Kerwin, MaryLouise E; Dugosh, Karen L; Carpenedo, Carolyn M; Bresani, Elena; Haugh, James A; Washio, Yukiko; Meyers, Robert J

    2017-11-01

    Community Reinforcement and Family Training (CRAFT) assists family members with a treatment-resistant loved one. The most consistent outcome of CRAFT is increased treatment entry of the identified treatment-resistant person (IP). This led us to question whether all 6 components of CRAFT are necessary. In a randomized clinical trial, 115 concerned significant others (CSOs) of an IP received 12-14 sessions of the full CRAFT intervention, 4-6 sessions focused on Treatment Entry Training (TEnT), or 12-14 sessions of Al-Anon/Nar-Anon Facilitation (ANF). We monitored treatment entry, attendance, and substance use of the IP and the CSO's mood and functioning. Data were collected at baseline and 4, 6, and 9 months after the baseline. We found significant reductions in time to treatment entry (χ(2)2 = 8.89, p = .01) and greater treatment entry rates for CRAFT (62%; odds ratio [OR] = 2.7, 95% confidence interval [CI] = 1.1-6.9) and TEnT (63%; OR = 2.9, 95% CI = 1.2-7.5) compared with ANF (37%), but CRAFT and TEnT did not differ significantly from each other (OR = 1.1, 95% CI = 0.4-2.7). No between-group differences in IP drug use were reported by CSOs, but days of drug use decreased over time for all groups (F(3, 277) = 13.47, p CRAFT produces greater treatment entry rates than ANF and found similar treatment entry rates for CRAFT and TEnT. This suggests that treatment entry training is sufficient for producing the best established outcome of CRAFT. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  18. Platelet-rich plasma for chronic lateral epicondylitis: is one injection sufficient?

    Science.gov (United States)

    Glanzmann, Michael C; Audigé, Laurent

    2015-12-01

    Chronic lateral epicondylitis is generally treated using nonsurgical methods including physiotherapy and infiltrations of cortisone or platelet-rich plasma (PRP). The latter is known for its simple application as well as associated low risk of adverse events, which lend to its widespread use in treating various musculoskeletal conditions. There is limited evidence on the effectiveness of PRP injections to optimally treat chronic lateral epicondylitis. This study explored the effectiveness of single or repeated injections for patients with symptoms that spanned 6 months or more and were unresponsive to alternate conservative measures. Patients with chronic lateral epicondylitis received PRP injections in 4-week intervals that were complemented with standardized physical therapy. Patient-reported outcomes based on the patient-rated elbow evaluation (PREE), quick disabilities of the arm, shoulder and hand (qDASH), and EuroQol (five dimensions) 3-level version (EQ5D3L) questionnaires were documented at each visit including 6 months after the first injection. These outcomes were compared between patients receiving 1 vs. 2 or 3 PRP injections. Sixty-two patients received one (n = 36) or more (n = 26) PRP injections. The mean baseline to 6-month follow-up scores of the PREE and qDASH questionnaires improved significantly from 54.0 to 23.0 and 50.3 to 20.7, respectively. The mean baseline EQ5D3L-visual analogue scale score improved from 62.5 to 82.9 by 6 months post-injection. These outcomes did not significantly differ between the patients who received varying numbers of injections. Patients with chronic lateral epicondylitis reported significant pain relief and gain in function as well as quality of life 6 months after localized PRP treatment. A single PRP injection may be sufficient.

  19. Are single odorous components of a predator sufficient to elicit defensive behaviors in prey species?

    Directory of Open Access Journals (Sweden)

    Raimund eApfelbach

    2015-07-01

    Full Text Available When exposed to the odor of a sympatric predator, prey animals typically display escape or defensive responses. These phenomena have been well-documented, especially in rodents, when exposed to the odor of a cat, ferret or fox. As a result of these experiments new discussions center on the following questions: 1 is a single volatile compound such as a major or a minor mixture constituent in urine or feces, emitted by the predator sufficient to cause defensive reactions in a potential prey species or 2 is a whole array of odors required to elicit a response and 3 will the relative size or escapability of the prey as compared to the predator influence responsiveness. Most predator-prey studies on this topic have been performed in the laboratory or under semi-natural conditions. Field studies could help to find answers to these questions. Australian mammals are completely naïve towards the introduced placental carnivores. That offers ideal opportunities to analyze in the field the responses of potential prey species to unknown predator odors. During the last decades researchers have accumulated an enormous amount of data exploring the effects of eutherian predator odors on native marsupial mammals. In this review, we will give a survey about the development of olfactory research, chemical signals and their influence on the behavior and - in some cases - physiology of prey species. In addition, we report on the effects of predator odor experiments performed under natural conditions in Australia. When studying all these literature we learned that data gained under controlled laboratory conditions elucidate the role of individual odors on brain structures and ultimately on a comparatively narrow range behaviors. In contrast to single odors odor arrays mimic much more the situation prey animals are confronted to in nature. Therefore, a broad range of methodology — from chemistry to ecology including anatomy, physiology and behavior — is needed to

  20. The floor plate is sufficient for development of the sclerotome and spine without the notochord.

    Science.gov (United States)

    Ando, Takashi; Semba, Kei; Suda, Hiroko; Sei, Akira; Mizuta, Hiroshi; Araki, Masatake; Abe, Kuniya; Imai, Kenji; Nakagata, Naomi; Araki, Kimi; Yamamura, Ken-ichi

    2011-01-01

    Danforth'sshort-tail (Sd) mouse is a semi-dominant mutation affecting the development of the vertebral column. Although the notochord degenerates completely by embryonic day 9.5, the vertebral column exists up to the lumber region, suggesting that the floor plate can substitute for notochord function. We previously established the mutant mouse line, Skt(Gt), through gene trap mutagenesis and identified the novel gene, Skt, which was mapped 0.95cM distal to the Sd locus. Taking advantage of the fact that monitoring notochordal development and genotyping of the Sd locus can be performed using the Skt(Gt) allele, we assessed the development of the vertebra, notochord, somite, floor plate and sclerotome in +-+/+-Skt(Gt), Sd-+/+-+, Sd-Skt(Gt)/+-+, Sd-Skt(Gt)/+-Skt(Gt), Sd-+/Sd-+ and Sd-Skt(Gt)/Sd-Skt(Gt) embryos. In Sd homozygous mutants with a C57BL/6 genetic background, the vertebral column was truncated in the 6th thoracic vertebra, which was more severe than previously reported. The floor plate and sclerotome developed to the level of somite before notochord degeneration and the number of remaining vertebrae corresponded well with the level of development of the floor plate and sclerotome. Defects to the sclerotome and subsequent vertebral development were not due to failure of somitogenesis. Taken together, these results suggest that the notochord induced floor plate development before degeneration, and that the remaining floor plate is sufficient for maintenance of differentiation of the somite into the sclerotome and vertebra in the absence of the notochord. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  1. Social Experience Is Sufficient to Modulate Sleep Need of Drosophila without Increasing Wakefulness.

    Science.gov (United States)

    Lone, Shahnaz Rahman; Potdar, Sheetal; Srivastava, Manishi; Sharma, Vijay Kumar

    2016-01-01

    Organisms quickly learn about their surroundings and display synaptic plasticity which is thought to be critical for their survival. For example, fruit flies Drosophila melanogaster exposed to highly enriched social environment are found to show increased synaptic connections and a corresponding increase in sleep. Here we asked if social environment comprising a pair of same-sex individuals could enhance sleep in the participating individuals. To study this, we maintained individuals of D. melanogaster in same-sex pairs for a period of 1 to 4 days, and after separation, monitored sleep of the previously socialized and solitary individuals under similar conditions. Males maintained in pairs for 3 or more days were found to sleep significantly more during daytime and showed a tendency to fall asleep sooner as compared to solitary controls (both measures together are henceforth referred to as "sleep-enhancement"). This sleep phenotype is not strain-specific as it is observed in males from three different "wild type" strains of D. melanogaster. Previous studies on social interaction mediated sleep-enhancement presumed 'waking experience' during the interaction to be the primary underlying cause; however, we found sleep-enhancement to occur without any significant increase in wakefulness. Furthermore, while sleep-enhancement due to group-wise social interaction requires Pigment Dispersing Factor (PDF) positive neurons; PDF positive and CRYPTOCHROME (CRY) positive circadian clock neurons and the core circadian clock genes are not required for sleep-enhancement to occur when males interact in pairs. Pair-wise social interaction mediated sleep-enhancement requires dopamine and olfactory signaling, while visual and gustatory signaling systems seem to be dispensable. These results suggest that socialization alone (without any change in wakefulness) is sufficient to cause sleep-enhancement in fruit fly D. melanogaster males, and that its neuronal control is context-specific.

  2. Bariatric Surgery in Adolescents: Is Routine Nutrient Supplementation Sufficient to Avoid Anemia Following Bariatric Surgery?

    Science.gov (United States)

    Goldberg, Hanna R; Chin, Vivian L; Zitsman, Jeffrey L; Zhang, Chengchen; Williams, Kristen M; Oberfield, Sharon; Fennoy, Ilene

    2017-08-01

    Anemia following bariatric surgery is a known complication. To prevent nutrient deficiencies, adolescents require multivitamin/mineral supplementation following bariatric surgery. The purpose of this study was to investigate if routine multivitamin/mineral supplementation is sufficient to prevent anemia in adolescents undergoing bariatric surgery, particularly sleeve gastrectomy (SG), a procedure that may induce nutrient malabsorption. We conducted a retrospective review of pediatric patients who underwent SG (34 patients) and laparoscopic adjustable gastric banding (LAGB) (141 patients) (January 2006 through December 2013). We examined anemia marker levels (iron, ferritin, folate, B 12 , hemoglobin, and hematocrit) at first visit and 3, 6, and 12 months postsurgery by repeated-measures analysis adjusting for weight loss. Following SG, folate levels decreased 3 and 6 months postsurgery but returned to baseline levels at 12 months. Furthermore, the SG group demonstrated lower folate levels compared with LAGB at 3 and 6 months. B 12 levels decreased 6 months post-SG but returned to baseline at 12 months. Following LAGB, B 12 levels decreased 12 months postsurgery compared with baseline. Ferritin levels decreased 3 months post-LAGB but returned to baseline levels at 6 months. There were no changes within groups or differences between groups in iron, hemoglobin, or hematocrit. While anemia did not occur in any patients while on recommended routine supplementation, folate levels were significantly reduced following SG and were lower in SG compared with LAGB patients. Additional folate supplementation seemed to improve folate levels, which highlights the importance of ongoing surveillance by primary care providers and the need for additional folate supplementation following SG.

  3. Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis.

    Science.gov (United States)

    Kreye, Jakob; Wenke, Nina K; Chayka, Mariya; Leubner, Jonas; Murugan, Rajagopal; Maier, Nikolaus; Jurek, Betty; Ly, Lam-Thanh; Brandl, Doreen; Rost, Benjamin R; Stumpf, Alexander; Schulz, Paulina; Radbruch, Helena; Hauser, Anja E; Pache, Florence; Meisel, Andreas; Harms, Lutz; Paul, Friedemann; Dirnagl, Ulrich; Garner, Craig; Schmitz, Dietmar; Wardemann, Hedda; Prüss, Harald

    2016-10-01

    SEE ZEKERIDOU AND LENNON DOI101093/AWW213 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently discovered autoimmune syndrome associated with psychosis, dyskinesias, and seizures. Little is known about the cerebrospinal fluid autoantibody repertoire. Antibodies against the NR1 subunit of the NMDAR are thought to be pathogenic; however, direct proof is lacking as previous experiments could not distinguish the contribution of further anti-neuronal antibodies. Using single cell cloning of full-length immunoglobulin heavy and light chain genes, we generated a panel of recombinant monoclonal NR1 antibodies from cerebrospinal fluid memory B cells and antibody secreting cells of NMDAR encephalitis patients. Cells typically carried somatically mutated immunoglobulin genes and had undergone class-switching to immunoglobulin G, clonally expanded cells carried identical somatic hypermutation patterns. A fraction of NR1 antibodies were non-mutated, thus resembling 'naturally occurring antibodies' and indicating that tolerance induction against NMDAR was incomplete and somatic hypermutation not essential for functional antibodies. However, only a small percentage of cerebrospinal fluid-derived antibodies reacted against NR1. Instead, nearly all further antibodies bound specifically to diverse brain-expressed epitopes including neuronal surfaces, suggesting that a broad repertoire of antibody-secreting cells enrich in the central nervous system during encephalitis. Our functional data using primary hippocampal neurons indicate that human cerebrospinal fluid-derived monoclonal NR1 antibodies alone are sufficient to cause neuronal surface receptor downregulation and subsequent impairment of NMDAR-mediated currents, thus providing ultimate proof of antibody pathogenicity. The observed formation of immunological memory might be relevant for clinical relapses. © The Author (2016). Published by Oxford University Press on

  4. Retrieval per se is not sufficient to trigger reconsolidation of human fear memory.

    Science.gov (United States)

    Sevenster, Dieuwke; Beckers, Tom; Kindt, Merel

    2012-03-01

    necessarily affect the cognitive component and vice versa. Second, mere retrieval of the fear memory is not sufficient to induce its labilization and reconsolidation. Copyright © 2012 Elsevier Inc. All rights reserved.

  5. The Ebola virus glycoprotein contributes to but is not sufficient for virulence in vivo.

    Directory of Open Access Journals (Sweden)

    Allison Groseth

    Full Text Available Among the Ebola viruses most species cause severe hemorrhagic fever in humans; however, Reston ebolavirus (REBOV has not been associated with human disease despite numerous documented infections. While the molecular basis for this difference remains unclear, in vitro evidence has suggested a role for the glycoprotein (GP as a major filovirus pathogenicity factor, but direct evidence for such a role in the context of virus infection has been notably lacking. In order to assess the role of GP in EBOV virulence, we have developed a novel reverse genetics system for REBOV, which we report here. Together with a previously published full-length clone for Zaire ebolavirus (ZEBOV, this provides a unique possibility to directly investigate the role of an entire filovirus protein in pathogenesis. To this end we have generated recombinant ZEBOV (rZEBOV and REBOV (rREBOV, as well as chimeric viruses in which the glycoproteins from these two virus species have been exchanged (rZEBOV-RGP and rREBOV-ZGP. All of these viruses could be rescued and the chimeras replicated with kinetics similar to their parent virus in tissue culture, indicating that the exchange of GP in these chimeric viruses is well tolerated. However, in a mouse model of infection rZEBOV-RGP demonstrated markedly decreased lethality and prolonged time to death when compared to rZEBOV, confirming that GP does indeed contribute to the full expression of virulence by ZEBOV. In contrast, rREBOV-ZGP did not show any signs of virulence, and was in fact slightly attenuated compared to rREBOV, demonstrating that GP alone is not sufficient to confer a lethal phenotype or exacerbate disease in this model. Thus, while these findings provide direct evidence that GP contributes to filovirus virulence in vivo, they also clearly indicate that other factors are needed for the acquisition of full virulence.

  6. Social Experience Is Sufficient to Modulate Sleep Need of Drosophila without Increasing Wakefulness.

    Directory of Open Access Journals (Sweden)

    Shahnaz Rahman Lone

    Full Text Available Organisms quickly learn about their surroundings and display synaptic plasticity which is thought to be critical for their survival. For example, fruit flies Drosophila melanogaster exposed to highly enriched social environment are found to show increased synaptic connections and a corresponding increase in sleep. Here we asked if social environment comprising a pair of same-sex individuals could enhance sleep in the participating individuals. To study this, we maintained individuals of D. melanogaster in same-sex pairs for a period of 1 to 4 days, and after separation, monitored sleep of the previously socialized and solitary individuals under similar conditions. Males maintained in pairs for 3 or more days were found to sleep significantly more during daytime and showed a tendency to fall asleep sooner as compared to solitary controls (both measures together are henceforth referred to as "sleep-enhancement". This sleep phenotype is not strain-specific as it is observed in males from three different "wild type" strains of D. melanogaster. Previous studies on social interaction mediated sleep-enhancement presumed 'waking experience' during the interaction to be the primary underlying cause; however, we found sleep-enhancement to occur without any significant increase in wakefulness. Furthermore, while sleep-enhancement due to group-wise social interaction requires Pigment Dispersing Factor (PDF positive neurons; PDF positive and CRYPTOCHROME (CRY positive circadian clock neurons and the core circadian clock genes are not required for sleep-enhancement to occur when males interact in pairs. Pair-wise social interaction mediated sleep-enhancement requires dopamine and olfactory signaling, while visual and gustatory signaling systems seem to be dispensable. These results suggest that socialization alone (without any change in wakefulness is sufficient to cause sleep-enhancement in fruit fly D. melanogaster males, and that its neuronal control is

  7. The effect of formal training of cardiopulmonary resuscitation (CPR skills on medical students perceived self-sufficiency

    Directory of Open Access Journals (Sweden)

    Shaghaghi A

    2004-07-01

    Full Text Available Background: Experience of cardiopulmonary resuscitation (CPR in real clinical setting is not easily possible for all medical students. Purpose: To assess medical student perceived self-sufficiency on three procedural skill on internship courses after they had taken a training course in clerkship period. Methods: Forty three medical students who had attended a workshop on CPR, tracheal intubations and venopuncture answered the questionnaires on their perceived self-sufficiency in performing these procedures after serving a few months as interns. Results: The mean score for perceived self-sufficiency (PSS was 75.84 (±18.63.Thre were a high correlation between the score given for the applicability of training in real life situation and the stress reduction scores on first time performing the procedure. Conclusion: The high degree of correlation between PSS scores and applicability scores, may warrant the consideration of new methods in procedural skills. Keywords: SKILL TRAINING, CPR TRAINING, PERCEIVED SELF-SUFFICIENCY

  8. Applied Control Systems Design

    CERN Document Server

    Mahmoud, Magdi S

    2012-01-01

    Applied Control System Design examines several methods for building up systems models based on real experimental data from typical industrial processes and incorporating system identification techniques. The text takes a comparative approach to the models derived in this way judging their suitability for use in different systems and under different operational circumstances. A broad spectrum of control methods including various forms of filtering, feedback and feedforward control is applied to the models and the guidelines derived from the closed-loop responses are then composed into a concrete self-tested recipe to serve as a check-list for industrial engineers or control designers. System identification and control design are given equal weight in model derivation and testing to reflect their equality of importance in the proper design and optimization of high-performance control systems. Readers’ assimilation of the material discussed is assisted by the provision of problems and examples. Most of these e...

  9. APPLIED ORGANIZATION OF CONSTRUCTION

    Directory of Open Access Journals (Sweden)

    Kievskiy Leonid Vladimirovich

    2017-03-01

    Full Text Available Applied disciplines in the sphere of construction which are engaged in the solution of vital macroeconomical problems (the general trend of development of these disciplines is the expansion of problematics and mutual integration are considered. Construction organization characteristic at the present stage as a systems engineering discipline covering the investment process of creation of real estate items, is given. The main source of current research trends for applied sciences (socio-economic development forecasts, regional and local programs is determined. Interpenetration and integration of various fields of knowledge exemplified by the current interindustry problem of blocks renovation organization of existing development, is demonstrated. Mathematical model of wave construction (for the period of deployment is proposed. Nature of dependence of the total duration of renovation on the limit of annual input and coefficient of renovation, is established. Overall structure of the Moscow region housing market is presented, and approaches to definition of effective demand are proposed.

  10. Applied evaluative informetrics

    CERN Document Server

    Moed, Henk F

    2017-01-01

    This book focuses on applied evaluative informetric artifacts or topics. It explains the base notions and assumptions of evaluative informetrics by discussing a series of important applications. The structure of the book is therefore not organized by methodological characteristics, but is centered around popular, often discussed or used informetric artifacts - indicators, methodologies, products, databases - or so called hot topics in which informetric indicators play an important role. Most of the artifacts and topics emerged during the past decade. The principal aim of the book is to present a state of the art in applied evaluative informetrics, and to inform the readers about the pros and cons, potentialities and limitations of the use of informetric/bibliometric indicators in research assessment. The book is a continuation of the book Citation Analysis in Research Evaluation (Springer, 2005). It is of interest to non-specialists, especially research students at advanced master level and higher, all thos...

  11. Applied statistics for economists

    CERN Document Server

    Lewis, Margaret

    2012-01-01

    This book is an undergraduate text that introduces students to commonly-used statistical methods in economics. Using examples based on contemporary economic issues and readily-available data, it not only explains the mechanics of the various methods, it also guides students to connect statistical results to detailed economic interpretations. Because the goal is for students to be able to apply the statistical methods presented, online sources for economic data and directions for performing each task in Excel are also included.

  12. Methods of applied mathematics

    CERN Document Server

    Hildebrand, Francis B

    1992-01-01

    This invaluable book offers engineers and physicists working knowledge of a number of mathematical facts and techniques not commonly treated in courses in advanced calculus, but nevertheless extremely useful when applied to typical problems in many different fields. It deals principally with linear algebraic equations, quadratic and Hermitian forms, operations with vectors and matrices, the calculus of variations, and the formulations and theory of linear integral equations. Annotated problems and exercises accompany each chapter.

  13. Applied mediation analyses

    DEFF Research Database (Denmark)

    Lange, Theis; Hansen, Kim Wadt; Sørensen, Rikke

    2017-01-01

    In recent years, mediation analysis has emerged as a powerful tool to disentangle causal pathways from an exposure/treatment to clinically relevant outcomes. Mediation analysis has been applied in scientific fields as diverse as labour market relations and randomized clinical trials of heart...... disease treatments. In parallel to these applications, the underlying mathematical theory and computer tools have been refined. This combined review and tutorial will introduce the reader to modern mediation analysis including: the mathematical framework; required assumptions; and software implementation...

  14. Applied longitudinal analysis

    CERN Document Server

    Fitzmaurice, Garrett M; Ware, James H

    2012-01-01

    Praise for the First Edition "". . . [this book] should be on the shelf of everyone interested in . . . longitudinal data analysis.""-Journal of the American Statistical Association   Features newly developed topics and applications of the analysis of longitudinal data Applied Longitudinal Analysis, Second Edition presents modern methods for analyzing data from longitudinal studies and now features the latest state-of-the-art techniques. The book emphasizes practical, rather than theoretical, aspects of methods for the analysis of diverse types of lo

  15. Applied clinical engineering

    International Nuclear Information System (INIS)

    Feinberg, B.

    1986-01-01

    This book demonstrates how clinical engineering has applied engineering principles to the development and use of complex medical devices for the diagnosis and treatment of the sick and injured. It discusses the proper utilization of medical devices and equipment in the health-care industry and provides understanding of complex engineering systems, and their uses in the modern hospital or other health-care facility

  16. 34 CFR 350.4 - What regulations apply?

    Science.gov (United States)

    2010-07-01

    ... (IRB) reviews research that purposefully requires inclusion of children with disabilities or... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION DISABILITY AND REHABILITATION RESEARCH PROJECTS AND CENTERS PROGRAM General § 350.4 What regulations apply? The following regulations apply to the Disability and...

  17. Is the diurnal pattern sufficient to explain the intraday variation in volatility? A nonparametric assessment

    DEFF Research Database (Denmark)

    Christensen, Kim; Hounyo, Ulrich; Podolskij, Mark

    In this paper, we propose a nonparametric way to test the hypothesis that time-variation in intraday volatility is caused solely by a deterministic and recurrent diurnal pattern. We assume that noisy high-frequency data from a discretely sampled jump-diffusion process are available. The test...... inference, we propose a new bootstrap approach, which leads to almost correctly sized tests of the null hypothesis. We apply the developed framework to a large cross-section of equity high-frequency data and find that the diurnal pattern accounts for a rather significant fraction of intraday variation...

  18. Sufficient convergency conditions for an implicit class of incomplete factorization circuits

    International Nuclear Information System (INIS)

    Artem'ev, V.K.

    1984-01-01

    The convergence for an implicit class of incomplete factorization circuits with peripheral compensation is theoretically investigated. The convergence theorem is indicated. Sufficiert conditions for the circuit parameters providing the convergence are obtained. The parameters selection may be program-realized, one parameter remaining free. For account of selection of this parameter the method convergence rate may be optimized. Numerical experiments and comparisons with other methods with model problems have shown the efficiency of incomplete factorization circuits. The method is applied for calculating reactors for the solution of hydrodynamic and thermal problems

  19. 42 CFR 435.117 - Newborn children.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Newborn children. 435.117 Section 435.117 Public..., Children Under 8, and Newborn Children § 435.117 Newborn children. (a) The agency must provide Medicaid eligibility to a child born to a woman who has applied for, has been determined eligible and is receiving...

  20. Procalcitonin is not sufficiently reliable to be the sole marker of neonatal sepsis of nosocomial origin

    Directory of Open Access Journals (Sweden)

    Moro Serrano Manuel

    2006-05-01

    Full Text Available Abstract Background It has recently been suggested that serum procalcitonin (PCT is of value in the diagnosis of neonatal sepsis, with varying results. The aim of this prospective multicenter study was to assess the usefulness of PCT as a marker of neonatal sepsis of nosocomial origin. Methods One hundred infants aged between 4 and 28 days of life admitted to the Neonatology Services of 13 acute-care teaching hospitals in Spain over 1-year with clinical suspicion of neonatal sepsis of nosocomial origin were included in the study. Serum PCT concentrations were determined by a specific immunoluminometric assay. The reliability of PCT for the diagnosis of nosocomial neonatal sepsis at the time of suspicion of infection and at 12–24 h and 36–48 h after the onset of symptoms was calculated by receiver-operating characteristics (ROC curves. The Youden's index (sensitivity + specificity - 1 was used for determination of optimal cutoff values of the diagnostic tests in the different postnatal periods. Sensitivity, specificity, and the likelihood ratio of a positive and negative result with the 95% confidence interval (CI were calculated. Results The diagnosis of nosocomial sepsis was confirmed in 61 neonates. Serum PCT concentrations were significantly higher at initial suspicion and at 12–24 h and 36–48 h after the onset of symptoms in neonates with confirmed sepsis than in neonates with clinically suspected but not confirmed sepsis. Optimal PCT thresholds according to ROC curves were 0.59 ng/mL at the time of suspicion of sepsis (sensitivity 81.4%, specificity 80.6%; 1.34 ng/mL within 12–24 h of birth (sensitivity 73.7%, specificity 80.6%, and 0.69 ng/mL within 36–48 h of birth (sensitivity 86.5%, specificity 72.7%. Conclusion Serum PCT concentrations showed a moderate diagnostic reliability for the detection of nosocomial neonatal sepsis from the time of suspicion of infection. PCT is not sufficiently reliable to be the sole marker of

  1. The Singaporean response to the SARS outbreak: knowledge sufficiency versus public trust.

    Science.gov (United States)

    Deurenberg-Yap, M; Foo, L L; Low, Y Y; Chan, S P; Vijaya, K; Lee, M

    2005-12-01

    knowledge on the one hand and high confidence and trust in the actions of the government on the other suggests that Singaporeans do not require high knowledge sufficiency to be confident in measures undertaken by the government to control the SARS crisis.

  2. Prospect of Cattle Development to Support Self Sufficiency of Meat in North Sumatera Province

    Directory of Open Access Journals (Sweden)

    Akhmad Rifai Lubis

    2010-06-01

    Full Text Available Shortage of beef supply to meet national needs is also found locally in North Sumatera Province. The trend for beef in this area was triggered by the increasing of population, economic improvement and desire for better nutrient comsumption. Level of beef consumption is increased 17% from year 2004 to 2008, so in the same period the number of cattle entered into the North Sumatera Province also increased. Some efforts had been conducted to develop beef cattle program in North Sumatera Self Sufficiency Program in Beef through technical and policy approaches. Several programs have been developed to accelerate the development of productivity and the population in North Sumatra, among others, 1 Agribusiness Development Program, 2 Food Security Improvement Program, 3 Farmer's Welfare Program; which are financed by both central and local budgets. Institutional aspects that have been developed to support the PSDS-2014 is the Regional Artificial Insemination Center to serve the needs of semen for districts and municipalities in the Province of North Sumatera. In the year 2008, it has been distributed as many as 44 000 doses of semen for frozen semen to meet the demands of 11 Districts. The amount of land resources for development indicated the availability of pastural land area of 1,311,159 ha from oil palm and rubber plantation, area of 1,192,172 ha for crops and livestock integration system. It is estimated that biomass production of rice straw, bean straw and sugarcane straw reaches 7,062,227; 68 145 and 14 664 tons per year, respectively. Also available as many as 689,478 tons of rice bran and palm oil industry waste as much as 4,159,203 tons per year. Some challenges in the North Sumatera PSDS programs in accordance with a predetermined time include: 1 Not all of the stakeholders get a complete information about the program, 2 the difficulties to prevent productive cows being slaughtered, 3 limited capital in an effort to pick up and redistribute

  3. A single alcohol drinking session is sufficient to enable subsequent aversion-resistant consumption in mice.

    Science.gov (United States)

    Lei, Kelly; Wegner, Scott A; Yu, Ji-Hwan; Simms, Jeffrey A; Hopf, F Woodward

    2016-09-01

    Addiction is mediated in large part by pathological motivation for rewarding, addictive substances, and alcohol-use disorders (AUDs) continue to extract a very high physical and economic toll on society. Compulsive alcohol drinking, where intake continues despite negative consequences, is considered a particular obstacle during treatment of AUDs. Aversion-resistant drives for alcohol have been modeled in rodents, where animals continue to consume even when alcohol is adulterated with the bitter tastant quinine, or is paired with another aversive consequence. Here, we describe a two-bottle choice paradigm where C57BL/6 mice first had 24-h access to 15% alcohol or water. Afterward, they drank quinine-free alcohol (alcohol-only) or alcohol with quinine (100 μM), in a limited daily access (LDA) two-bottle-choice paradigm (2 h/day, 5 days/week, starting 3 h into the dark cycle), and achieved nearly binge-level blood alcohol concentrations. Interestingly, a single, initial 24-h experience with alcohol-only enhanced subsequent quinine-resistant drinking. In contrast, mice that drank alcohol-quinine in the 24-h session showed significantly reduced alcohol-quinine intake and preference during the subsequent LDA sessions, relative to mice that drank alcohol-only in the initial 24-h session and alcohol-quinine in LDA sessions. Thus, mice could find the concentration of quinine we used aversive, but were able to disregard the quinine after a single alcohol-only drinking session. Finally, mice had low intake and preference for quinine in water, both before and after weeks of alcohol-drinking sessions, suggesting that quinine resistance was not a consequence of increased quinine preference after weeks of drinking of alcohol-quinine. Together, we demonstrate that a single alcohol-only session was sufficient to enable subsequent aversion-resistant consumption in C57BL/6 mice, which did not reflect changes in quinine taste palatability. Given the rapid development of quinine

  4. Are single odorous components of a predator sufficient to elicit defensive behaviors in prey species?

    Science.gov (United States)

    Apfelbach, Raimund; Parsons, Michael H; Soini, Helena A; Novotny, Milos V

    2015-01-01

    When exposed to the odor of a sympatric predator, prey animals typically display escape or defensive responses. These phenomena have been well-documented, especially in rodents, when exposed to the odor of a cat, ferret, or fox. As a result of these experiments new discussions center on the following questions: (1) is a single volatile compound such as a major or a minor mixture constituent in urine or feces, emitted by the predator sufficient to cause defensive reactions in a potential prey species or (2) is a whole array of odors required to elicit a response and (3) will the relative size or escapability of the prey as compared to the predator influence responsiveness. Most predator-prey studies on this topic have been performed in the laboratory or under semi-natural conditions. Field studies could help to find answers to these questions. Australian mammals are completely naïve toward the introduced placental carnivores. That offers ideal opportunities to analyze in the field the responses of potential prey species to unknown predator odors. During the last decades researchers have accumulated an enormous amount of data exploring the effects of eutherian predator odors on native marsupial mammals. In this review, we will give a survey about the development of olfactory research, chemical signals and their influence on the behavior and-in some cases-physiology of prey species. In addition, we report on the effects of predator odor experiments performed under natural conditions in Australia. When studying all these literature we learned that data gained under controlled laboratory conditions elucidate the role of individual odors on brain structures and ultimately on a comparatively narrow range behaviors. In contrast to single odors odor arrays mimic much more the situation prey animals are confronted to in nature. Therefore, a broad range of methodology-from chemistry to ecology including anatomy, physiology, and behavior-is needed to understand all the

  5. Paranormal phenomena in the medical literature sufficient smoke to warrant a search for fire.

    Science.gov (United States)

    Bobrow, Robert S

    2003-06-01

    Paranormal phenomena - events that cannot be explained by existing science - are regularly reported in medicine. Surveys have shown that a majority of the population of the United States and Great Britain hold at least one paranormal belief. Information was retrieved by MEDLINE searches using keywords 'paranormal' and 'psychic', and from the author's own collection. Reports are predominantly by physicians, and from peer-reviewed, MEDLINE-indexed literature. This is a representative sample, as there is no database for paranormal medical phenomena. Presented and discussed are: a case of systemic lupus erythematosis ameliorated by witchcraft; an analysis of studies on distant healing; acupuncture, as a bridge between what is now accepted but recently would have been deemed paranormal; a carefully-done study of a psychic; auditory hallucinations informing a patient, correctly, that she had a brain tumor; two nearly-identical lay press reports of self-predicted death; lycanthropy (the delusion of being an animal); the development of Carl Jung's collective unconscious; hypnosis - still questioned despite documented therapeutic benefit, and a well-researched report of a person speaking a foreign language, apparently unlearned (xenoglossy) while hypnotized; and multiple examples of children who spout the details of the life of an unknown, deceased person. The inability of existing paradigms to explain these observations does not negate them; rather, it elucidates a need for more research.

  6. The transcension hypothesis: Sufficiently advanced civilizations invariably leave our universe, and implications for METI and SETI

    Science.gov (United States)

    Smart, John M.

    2012-09-01

    The emerging science of evolutionary developmental ("evo devo") biology can aid us in thinking about our universe as both an evolutionary system, where most processes are unpredictable and creative, and a developmental system, where a special few processes are predictable and constrained to produce far-future-specific emergent order, just as we see in the common developmental processes in two stars of an identical population type, or in two genetically identical twins in biology. The transcension hypothesis proposes that a universal process of evolutionary development guides all sufficiently advanced civilizations into what may be called "inner space," a computationally optimal domain of increasingly dense, productive, miniaturized, and efficient scales of space, time, energy, and matter, and eventually, to a black-hole-like destination. Transcension as a developmental destiny might also contribute to the solution to the Fermi paradox, the question of why we have not seen evidence of or received beacons from intelligent civilizations. A few potential evolutionary, developmental, and information theoretic reasons, mechanisms, and models for constrained transcension of advanced intelligence are briefly considered. In particular, we introduce arguments that black holes may be a developmental destiny and standard attractor for all higher intelligence, as they appear to some to be ideal computing, learning, forward time travel, energy harvesting, civilization merger, natural selection, and universe replication devices. In the transcension hypothesis, simpler civilizations that succeed in resisting transcension by staying in outer (normal) space would be developmental failures, which are statistically very rare late in the life cycle of any biological developing system. If transcension is a developmental process, we may expect brief broadcasts or subtle forms of galactic engineering to occur in small portions of a few galaxies, the handiwork of young and immature

  7. Applied ALARA techniques

    International Nuclear Information System (INIS)

    Waggoner, L.O.

    1998-01-01

    The presentation focuses on some of the time-proven and new technologies being used to accomplish radiological work. These techniques can be applied at nuclear facilities to reduce radiation doses and protect the environment. The last reactor plants and processing facilities were shutdown and Hanford was given a new mission to put the facilities in a safe condition, decontaminate, and prepare them for decommissioning. The skills that were necessary to operate these facilities were different than the skills needed today to clean up Hanford. Workers were not familiar with many of the tools, equipment, and materials needed to accomplish:the new mission, which includes clean up of contaminated areas in and around all the facilities, recovery of reactor fuel from spent fuel pools, and the removal of millions of gallons of highly radioactive waste from 177 underground tanks. In addition, this work has to be done with a reduced number of workers and a smaller budget. At Hanford, facilities contain a myriad of radioactive isotopes that are 2048 located inside plant systems, underground tanks, and the soil. As cleanup work at Hanford began, it became obvious early that in order to get workers to apply ALARA and use hew tools and equipment to accomplish the radiological work it was necessary to plan the work in advance and get radiological control and/or ALARA committee personnel involved early in the planning process. Emphasis was placed on applying,ALARA techniques to reduce dose, limit contamination spread and minimize the amount of radioactive waste generated. Progress on the cleanup has,b6en steady and Hanford workers have learned to use different types of engineered controls and ALARA techniques to perform radiological work. The purpose of this presentation is to share the lessons learned on how Hanford is accomplishing radiological work

  8. Applied ALARA techniques

    Energy Technology Data Exchange (ETDEWEB)

    Waggoner, L.O.

    1998-02-05

    The presentation focuses on some of the time-proven and new technologies being used to accomplish radiological work. These techniques can be applied at nuclear facilities to reduce radiation doses and protect the environment. The last reactor plants and processing facilities were shutdown and Hanford was given a new mission to put the facilities in a safe condition, decontaminate, and prepare them for decommissioning. The skills that were necessary to operate these facilities were different than the skills needed today to clean up Hanford. Workers were not familiar with many of the tools, equipment, and materials needed to accomplish:the new mission, which includes clean up of contaminated areas in and around all the facilities, recovery of reactor fuel from spent fuel pools, and the removal of millions of gallons of highly radioactive waste from 177 underground tanks. In addition, this work has to be done with a reduced number of workers and a smaller budget. At Hanford, facilities contain a myriad of radioactive isotopes that are 2048 located inside plant systems, underground tanks, and the soil. As cleanup work at Hanford began, it became obvious early that in order to get workers to apply ALARA and use hew tools and equipment to accomplish the radiological work it was necessary to plan the work in advance and get radiological control and/or ALARA committee personnel involved early in the planning process. Emphasis was placed on applying,ALARA techniques to reduce dose, limit contamination spread and minimize the amount of radioactive waste generated. Progress on the cleanup has,b6en steady and Hanford workers have learned to use different types of engineered controls and ALARA techniques to perform radiological work. The purpose of this presentation is to share the lessons learned on how Hanford is accomplishing radiological work.

  9. Applied Semantic Web Technologies

    CERN Document Server

    Sugumaran, Vijayan

    2011-01-01

    The rapid advancement of semantic web technologies, along with the fact that they are at various levels of maturity, has left many practitioners confused about the current state of these technologies. Focusing on the most mature technologies, Applied Semantic Web Technologies integrates theory with case studies to illustrate the history, current state, and future direction of the semantic web. It maintains an emphasis on real-world applications and examines the technical and practical issues related to the use of semantic technologies in intelligent information management. The book starts with

  10. SIFT applied to CBIR

    Directory of Open Access Journals (Sweden)

    ALMEIDA, J.

    2009-12-01

    Full Text Available Content-Based Image Retrieval (CBIR is a challenging task. Common approaches use only low-level features. Notwithstanding, such CBIR solutions fail on capturing some local features representing the details and nuances of scenes. Many techniques in image processing and computer vision can capture these scene semantics. Among them, the Scale Invariant Features Transform~(SIFT has been widely used in a lot of applications. This approach relies on the choice of several parameters which directly impact its effectiveness when applied to retrieve images. In this paper, we discuss the results obtained in several experiments proposed to evaluate the application of the SIFT in CBIR tasks.

  11. Applied impulsive mathematical models

    CERN Document Server

    Stamova, Ivanka

    2016-01-01

    Using the theory of impulsive differential equations, this book focuses on mathematical models which reflect current research in biology, population dynamics, neural networks and economics. The authors provide the basic background from the fundamental theory and give a systematic exposition of recent results related to the qualitative analysis of impulsive mathematical models. Consisting of six chapters, the book presents many applicable techniques, making them available in a single source easily accessible to researchers interested in mathematical models and their applications. Serving as a valuable reference, this text is addressed to a wide audience of professionals, including mathematicians, applied researchers and practitioners.

  12. Applied energy an introduction

    CERN Document Server

    Abdullah, Mohammad Omar

    2012-01-01

    Introduction to Applied EnergyGeneral IntroductionEnergy and Power BasicsEnergy EquationEnergy Generation SystemsEnergy Storage and MethodsEnergy Efficiencies and LossesEnergy industry and Energy Applications in Small -Medium Enterprises (SME) industriesEnergy IndustryEnergy-Intensive industryEnergy Applications in SME Energy industriesEnergy Sources and SupplyEnergy SourcesEnergy Supply and Energy DemandEnergy Flow Visualization and Sankey DiagramEnergy Management and AnalysisEnergy AuditsEnergy Use and Fuel Consumption StudyEnergy Life-Cycle AnalysisEnergy and EnvironmentEnergy Pollutants, S

  13. Applied linear regression

    CERN Document Server

    Weisberg, Sanford

    2013-01-01

    Praise for the Third Edition ""...this is an excellent book which could easily be used as a course text...""-International Statistical Institute The Fourth Edition of Applied Linear Regression provides a thorough update of the basic theory and methodology of linear regression modeling. Demonstrating the practical applications of linear regression analysis techniques, the Fourth Edition uses interesting, real-world exercises and examples. Stressing central concepts such as model building, understanding parameters, assessing fit and reliability, and drawing conclusions, the new edition illus

  14. Applied Meteorology Unit (AMU)

    Science.gov (United States)

    Bauman, William; Crawford, Winifred; Barrett, Joe; Watson, Leela; Wheeler, Mark

    2010-01-01

    This report summarizes the Applied Meteorology Unit (AMU) activities for the first quarter of Fiscal Year 2010 (October - December 2009). A detailed project schedule is included in the Appendix. Included tasks are: (1) Peak Wind Tool for User Launch Commit Criteria (LCC), (2) Objective Lightning Probability Tool, Phase III, (3) Peak Wind Tool for General Forecasting, Phase II, (4) Upgrade Summer Severe Weather Tool in Meteorological Interactive Data Display System (MIDDS), (5) Advanced Regional Prediction System (ARPS) Data Analysis System (ADAS) Update and Maintainability, (5) Verify 12-km resolution North American Model (MesoNAM) Performance, and (5) Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) Graphical User Interface.

  15. Applied logistic regression

    CERN Document Server

    Hosmer, David W; Sturdivant, Rodney X

    2013-01-01

     A new edition of the definitive guide to logistic regression modeling for health science and other applications This thoroughly expanded Third Edition provides an easily accessible introduction to the logistic regression (LR) model and highlights the power of this model by examining the relationship between a dichotomous outcome and a set of covariables. Applied Logistic Regression, Third Edition emphasizes applications in the health sciences and handpicks topics that best suit the use of modern statistical software. The book provides readers with state-of-

  16. Herramientas y propuestas de innovación basadas en la tecnología de realidad aumentada aplicadas a la literatura infantil y juvenil / Tools and proposals for innovation based on augmented reality technology applied children's literature

    Directory of Open Access Journals (Sweden)

    Noelia Margarita Moreno Martínez

    2017-01-01

    implementation of this technology for addressing children's literature.

  17. Is Advanced Real-Time Energy Metering Sufficient to Persuade People to Save Energy?

    Directory of Open Access Journals (Sweden)

    Leite H.

    2012-10-01

    Full Text Available In order to promote a low-carbon economy, EU citizens may soon be able to check their electricity consumption from smart meter. It is hoped that smart meter can, by providing real-time consumption and pricing information to residential users, help reducing demand for electricity. It is argued in this paper that, according the Elaborative Likelihood Model (ELM, these methods are most likely to be effective when consumers perceive the issue of energy conservation relevant to their lives. Nevertheless, some fundamental characteristics of these methods result in limited amount of perceived personal relevance; for instance, energy expenditure expense may be relatively small comparing to other household expenditure like mortgage and consumption information does not enhance interpersonal trust. In this paper, it is suggested that smart meter can apply the “nudge” approaches which respond to ELM as the use of simple rules to make decision, which include the change of feedback delivery and device design.

  18. Is Advanced Real-Time Energy Metering Sufficient to Persuade People to Save Energy?

    Science.gov (United States)

    Ting, L.; Leite, H.; Ponce de Leão, T.

    2012-10-01

    In order to promote a low-carbon economy, EU citizens may soon be able to check their electricity consumption from smart meter. It is hoped that smart meter can, by providing real-time consumption and pricing information to residential users, help reducing demand for electricity. It is argued in this paper that, according the Elaborative Likelihood Model (ELM), these methods are most likely to be effective when consumers perceive the issue of energy conservation relevant to their lives. Nevertheless, some fundamental characteristics of these methods result in limited amount of perceived personal relevance; for instance, energy expenditure expense may be relatively small comparing to other household expenditure like mortgage and consumption information does not enhance interpersonal trust. In this paper, it is suggested that smart meter can apply the "nudge" approaches which respond to ELM as the use of simple rules to make decision, which include the change of feedback delivery and device design.

  19. Can a decentralized blood system ensure self-sufficiency and blood safety? The Lebanese experience.

    Science.gov (United States)

    Haddad, Antoine; Bou Assi, Tarek; Garraud, Olivier

    2017-08-01

    Lebanon has adopted a liberal economic system that also applies to healthcare procurement. There is no national Lebanese blood transfusion service and the blood supply is divided between a large number of licensed (45 per cent) and unlicensed (55 per cent) blood banks, many of them issuing a very limited number of blood components. All blood banks are hospital based and operate the entire transfusion chain, from collection to the release of blood units. Blood donation is voluntary and non-remunerated in 20-25 per cent of donations; it relies principally on replacement donations. Recently, Lebanon has faced political instability and war, and now welcomes an enormous number of refugees from neighboring countries at war. This has had an important impact on heath care and on the transfusion supply. We discuss the impact of the blood donation organization on the transfusion safety and ethics, to set the foundation for a more developed and safer transfusion programs.

  20. Economic potential of demand response at household level—Are Central-European market conditions sufficient?

    International Nuclear Information System (INIS)

    Prüggler, Natalie

    2013-01-01

    The aim of this paper is to show the economic potential of demand response (DR) on household level at Central European market conditions. Thereby, required economic benefits for consumers' participation, the realistic load shifting potential at household level and the estimation of essential intelligent infrastructure costs are discussed. The core of this paper builds a case-study applying spot market-oriented load shifting from the supplier's point of view by using Austrian electricity market data, household load profiles as well as a heat pump and e-car charging load profile. It is demonstrated which cost savings for suppliers can be derived from such load shifting procedure at household level. Furthermore, upper cost limits for intelligent infrastructure in order to break-even are derived. Results suggest to take a critical look at European discussions on DR implementation on household level, showing that at Central European market conditions the potential for DR at household level is restricted to significant loads and hence, the applied load shifting strategy is only beneficial with application to heat pumps. In contrast, the frequently discussed shifting of conventional household devices' loads (such as washing machines) economically does not add up. - Highlights: • Calculation of economic potential of domestic DR at Central European market conditions. • Model and case-study of spot market-oriented load shifting from supplier's perspective. • Derivation of supplier's cost savings and upper cost limits for ICT infrastructure. • Results show economic potential of domestic DR to be restricted to significant loads. • Shifting of washing machines economically does not pay off in contrast to heat pumps

  1. Sufficient Condition for Monotonicity in Constructing the Distribution Function With Bernoulli Scheme

    Directory of Open Access Journals (Sweden)

    Vedenyapin Aleksandr Dmitrievich

    2015-11-01

    by the function r(x, kmin: Pnk=Сnk[P(r(x, kmin]k[1-P(r(x, kmin]n-k. We defined the probability that the total index change will be in the section [x, nS] as the sum of the probabilities of incompatible events, for which the number of successes satisfies to entered inequality. Then obviously we defined the probability that the total index changing will be in the interval [nI, x. Then the function F(x was introduced, defined on the whole line, which is identical to the amount (probability that the total index changing will be in the interval in the interval (nI, nS], and is identical to zero and one in the additions. Some properties of the distribution function F(x are satisfied automatically. A sufficient condition for the monotonicity is presented in the form of Theorem 2.

  2. Applied plasma physics

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    Applied Plasma Physics is a major sub-organizational unit of the Magnetic Fusion Energy (MFE) Program. It includes Fusion Plasma Theory and Experimental Plasma Research. The Fusion Plasma Theory group has the responsibility for developing theoretical-computational models in the general areas of plasma properties, equilibrium, stability, transport, and atomic physics. This group has responsibility for giving guidance to the mirror experimental program. There is a formal division of the group into theory and computational; however, in this report the efforts of the two areas are not separated since many projects have contributions from members of both. Under the Experimental Plasma Research Program we are developing a neutral-beam source, the intense, pulsed ion-neutral source (IPINS), for the generation of a reversed-field configuration on 2XIIB. We are also studying the feasibility of using certain neutron-detection techniques as plasma diagnostics in the next generation of thermonuclear experiments

  3. Applied antineutrino physics workshop

    International Nuclear Information System (INIS)

    Lund, James C.

    2008-01-01

    This workshop is the fourth one of a series that includes the Neutrino Geophysics Conference at Honolulu, Hawaii, which I attended in 2005. This workshop was organized by the Astro-Particle and Cosmology laboratory in the recently opened Condoret building of the University of Paris. More information, including copies of the presentations, on the workshop is available on the website: www.apc.univ-paris7.fr/AAP2007/. The workshop aims at opening neutrino physics to various fields such that it can be applied in geosciences, nuclear industry (reactor and spent fuel monitoring) and non-proliferation. The workshop was attended by over 60 people from Europe, USA, Asia and Brazil. The meeting was also attended by representatives of the Comprehensive nuclear-Test Ban Treaty (CTBT) and the International Atomic Energy Agency (IAEA). The workshop also included a workshop dinner on board of a river boat sailing the Seine river

  4. Applied partial differential equations

    CERN Document Server

    Logan, J David

    2015-01-01

    This text presents the standard material usually covered in a one-semester, undergraduate course on boundary value problems and PDEs.  Emphasis is placed on motivation, concepts, methods, and interpretation, rather than on formal theory. The concise treatment of the subject is maintained in this third edition covering all the major ideas: the wave equation, the diffusion equation, the Laplace equation, and the advection equation on bounded and unbounded domains. Methods include eigenfunction expansions, integral transforms, and characteristics. In this third edition, text remains intimately tied to applications in heat transfer, wave motion, biological systems, and a variety other topics in pure and applied science. The text offers flexibility to instructors who, for example, may wish to insert topics from biology or numerical methods at any time in the course. The exposition is presented in a friendly, easy-to-read, style, with mathematical ideas motivated from physical problems. Many exercises and worked e...

  5. Applied computational physics

    CERN Document Server

    Boudreau, Joseph F; Bianchi, Riccardo Maria

    2018-01-01

    Applied Computational Physics is a graduate-level text stressing three essential elements: advanced programming techniques, numerical analysis, and physics. The goal of the text is to provide students with essential computational skills that they will need in their careers, and to increase the confidence with which they write computer programs designed for their problem domain. The physics problems give them an opportunity to reinforce their programming skills, while the acquired programming skills augment their ability to solve physics problems. The C++ language is used throughout the text. Physics problems include Hamiltonian systems, chaotic systems, percolation, critical phenomena, few-body and multi-body quantum systems, quantum field theory, simulation of radiation transport, and data modeling. The book, the fruit of a collaboration between a theoretical physicist and an experimental physicist, covers a broad range of topics from both viewpoints. Examples, program libraries, and additional documentatio...

  6. Applied statistical thermodynamics

    CERN Document Server

    Lucas, Klaus

    1991-01-01

    The book guides the reader from the foundations of statisti- cal thermodynamics including the theory of intermolecular forces to modern computer-aided applications in chemical en- gineering and physical chemistry. The approach is new. The foundations of quantum and statistical mechanics are presen- ted in a simple way and their applications to the prediction of fluid phase behavior of real systems are demonstrated. A particular effort is made to introduce the reader to expli- cit formulations of intermolecular interaction models and to show how these models influence the properties of fluid sy- stems. The established methods of statistical mechanics - computer simulation, perturbation theory, and numerical in- tegration - are discussed in a style appropriate for newcom- ers and are extensively applied. Numerous worked examples illustrate how practical calculations should be carried out.

  7. Applied plasma physics

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    Applied Plasma Physics is a major sub-organizational unit of the MFE Program. It includes Fusion Plasma Theory and Experimental Plasma Research. The Fusion Plasma Theory group has the responsibility for developing theoretical-computational models in the general areas of plasma properties, equilibrium, stability, transport, and atomic physics. This group has responsibility for giving guidance to the mirror experimental program. There is a formal division of the group into theory and computational; however, in this report the efforts of the two areas are not separated since many projects have contributions from members of both. Under the Experimental Plasma Research Program, we are developing the intense, pulsed neutral-beam source (IPINS) for the generation of a reversed-field configuration on 2XIIB. We are also studying the feasibility of utilizing certain neutron-detection techniques as plasma diagnostics in the next generation of thermonuclear experiments

  8. Applied linear algebra

    CERN Document Server

    Olver, Peter J

    2018-01-01

    This textbook develops the essential tools of linear algebra, with the goal of imparting technique alongside contextual understanding. Applications go hand-in-hand with theory, each reinforcing and explaining the other. This approach encourages students to develop not only the technical proficiency needed to go on to further study, but an appreciation for when, why, and how the tools of linear algebra can be used across modern applied mathematics. Providing an extensive treatment of essential topics such as Gaussian elimination, inner products and norms, and eigenvalues and singular values, this text can be used for an in-depth first course, or an application-driven second course in linear algebra. In this second edition, applications have been updated and expanded to include numerical methods, dynamical systems, data analysis, and signal processing, while the pedagogical flow of the core material has been improved. Throughout, the text emphasizes the conceptual connections between each application and the un...

  9. Applied number theory

    CERN Document Server

    Niederreiter, Harald

    2015-01-01

    This textbook effectively builds a bridge from basic number theory to recent advances in applied number theory. It presents the first unified account of the four major areas of application where number theory plays a fundamental role, namely cryptography, coding theory, quasi-Monte Carlo methods, and pseudorandom number generation, allowing the authors to delineate the manifold links and interrelations between these areas.  Number theory, which Carl-Friedrich Gauss famously dubbed the queen of mathematics, has always been considered a very beautiful field of mathematics, producing lovely results and elegant proofs. While only very few real-life applications were known in the past, today number theory can be found in everyday life: in supermarket bar code scanners, in our cars’ GPS systems, in online banking, etc.  Starting with a brief introductory course on number theory in Chapter 1, which makes the book more accessible for undergraduates, the authors describe the four main application areas in Chapters...

  10. Applied systems theory

    CERN Document Server

    Dekkers, Rob

    2017-01-01

    Offering an up-to-date account of systems theories and its applications, this book provides a different way of resolving problems and addressing challenges in a swift and practical way, without losing overview and grip on the details. From this perspective, it offers a different way of thinking in order to incorporate different perspectives and to consider multiple aspects of any given problem. Drawing examples from a wide range of disciplines, it also presents worked cases to illustrate the principles. The multidisciplinary perspective and the formal approach to modelling of systems and processes of ‘Applied Systems Theory’ makes it suitable for managers, engineers, students, researchers, academics and professionals from a wide range of disciplines; they can use this ‘toolbox’ for describing, analysing and designing biological, engineering and organisational systems as well as getting a better understanding of societal problems. This revised, updated and expanded second edition includes coverage of a...

  11. Applied multivariate statistical analysis

    CERN Document Server

    Härdle, Wolfgang Karl

    2015-01-01

    Focusing on high-dimensional applications, this 4th edition presents the tools and concepts used in multivariate data analysis in a style that is also accessible for non-mathematicians and practitioners.  It surveys the basic principles and emphasizes both exploratory and inferential statistics; a new chapter on Variable Selection (Lasso, SCAD and Elastic Net) has also been added.  All chapters include practical exercises that highlight applications in different multivariate data analysis fields: in quantitative financial studies, where the joint dynamics of assets are observed; in medicine, where recorded observations of subjects in different locations form the basis for reliable diagnoses and medication; and in quantitative marketing, where consumers’ preferences are collected in order to construct models of consumer behavior.  All of these examples involve high to ultra-high dimensions and represent a number of major fields in big data analysis. The fourth edition of this book on Applied Multivariate ...

  12. Applied mechanics of solids

    CERN Document Server

    Bower, Allan F

    2009-01-01

    Modern computer simulations make stress analysis easy. As they continue to replace classical mathematical methods of analysis, these software programs require users to have a solid understanding of the fundamental principles on which they are based. Develop Intuitive Ability to Identify and Avoid Physically Meaningless Predictions Applied Mechanics of Solids is a powerful tool for understanding how to take advantage of these revolutionary computer advances in the field of solid mechanics. Beginning with a description of the physical and mathematical laws that govern deformation in solids, the text presents modern constitutive equations, as well as analytical and computational methods of stress analysis and fracture mechanics. It also addresses the nonlinear theory of deformable rods, membranes, plates, and shells, and solutions to important boundary and initial value problems in solid mechanics. The author uses the step-by-step manner of a blackboard lecture to explain problem solving methods, often providing...

  13. Development of Walking and Self-sufficiency Ability Related to Nutrition among People with Down Syndrome

    Directory of Open Access Journals (Sweden)

    Brantmüller Éva

    2015-05-01

    Full Text Available Development of the walking ability and self-care of patients with Down syndrome is affected by their body weight determining their lifestyle to a great extent. Objectives: The study aimed at the determination of body mass index for persons living in residential institutions and families, exploration its impact on walking and self-care as two, objective factors of life quality. Method: Data collection of persons aged 3-35 with Down syndrome living in families covered seven counties, while those of living in residential institutions covered thirteen counties in Hungary. In the 183 cases studied 76 people in residential institutions, 107 people lived in families. The cross-sectional study was processed by non-random sample selection. The questionnaires were filled out by health visitors and care takers edited by their own. Results: 50.6% of adults and 26.1% of children belonged to the overweight or obese category. Their residence showed a significant correlation with the body mass index (p< 0.001. Overweight and obese persons in families, while thin ones were more prevalent in institutions. Regarding the walking ability and self-care of the persons living in families a significantly higher level of development was achieved (p< 0.001. Walking ability (p = 0.001 and self-care (p = 0,008 were worsened by less body weight significantly, while overweight or obesity influenced it less negatively. Discussion: The claim is not further acceptable whereas persons with Down syndrome are more prone to obesity than average people. However unfavourable weight gain in adults draws attention to the necessity to a healthy diet and regular exercise. The people living in residential institutions with significantly lower body mass index and the associated low development of walking ability and self-care envisages an urgent reform of residential institutions. Life in the institutions negatively affects the walking ability and self-care, and thus significantly reduces

  14. A new assessment method for demonstrating the sufficiency of the safety assessment and the safety margins of the geological disposal system

    International Nuclear Information System (INIS)

    Ohi, Takao; Kawasaki, Daisuke; Chiba, Tamotsu; Takase, Toshio; Hane, Koji

    2013-01-01

    A new method for demonstrating the sufficiency of the safety assessment and safety margins of the geological disposal system has been developed. The method is based on an existing comprehensive sensitivity analysis method and can systematically identify the successful conditions, under which the dose rate does not exceed specified safety criteria, using analytical solutions for nuclide migration and the results of a statistical analysis. The successful conditions were identified using three major variables. Furthermore, the successful conditions at the level of factors or parameters were obtained using relational equations between the variables and the factors or parameters making up these variables. In this study, the method was applied to the safety assessment of the geological disposal of transuranic waste in Japan. Based on the system response characteristics obtained from analytical solutions and on the successful conditions, the classification of the analytical conditions, the sufficiency of the safety assessment and the safety margins of the disposal system were then demonstrated. A new assessment procedure incorporating this method into the existing safety assessment approach is proposed in this study. Using this procedure, it is possible to conduct a series of safety assessment activities in a logical manner. (author)

  15. A single regulatory gene is sufficient to alter Vibrio aestuarianus pathogenicity in oysters.

    Science.gov (United States)

    Goudenège, David; Travers, Marie Agnès; Lemire, Astrid; Petton, Bruno; Haffner, Philippe; Labreuche, Yannick; Tourbiez, Delphine; Mangenot, Sophie; Calteau, Alexandra; Mazel, Didier; Nicolas, Jean Louis; Jacq, Annick; Le roux, Frédérique

    2015-11-01

    Oyster diseases caused by pathogenic vibrios pose a major challenge to the sustainability of oyster farming. In France, since 2012 a disease affecting specifically adult oysters has been associated with the presence of Vibrio aestuarianus. Here, by combining genome comparison, phylogenetic analyses and high-throughput infections of strains isolated before or during the recent outbreaks, we show that virulent strains cluster into two V. aestuarianus lineages independently of the sampling dates. The bacterial lethal dose was not different between strains isolated before or after 2012. Hence, the emergence of a new highly virulent clonal strain is unlikely. Each lineage comprises nearly identical strains, the majority of them being virulent, suggesting that within these phylogenetically coherent virulent lineages a few strains have lost their pathogenicity. Comparative genomics allowed the identification of a single frameshift in a non-virulent strain. This mutation affects the varS gene that codes for a signal transduction histidine-protein kinase. Genetic analyses confirmed that varS is necessary for infection of oysters and for a secreted metalloprotease expression. For the first time in a Vibrio species, we show here that VarS is a key factor of pathogenicity. © 2014 Society for Applied Microbiology and John Wiley & Sons Ltd.

  16. Guidelines for the Review of Environmental-Related Legislation Regarding the Realisation of the Right to Access to Sufficient Food

    Directory of Open Access Journals (Sweden)

    Inge Snyman

    2015-12-01

    Full Text Available The development of legislation for the progressive realisation of the right to access to sufficient food is labelled as an international and national objective. Section 27(2 of the Constitution of the Republic of South Africa, 1996 assigns a compulsory mandate to the South African government to take reasonable legislative and other measures, within its available resources, to achieve the progressive realisation of the right to access to sufficient food. The United Nations' Food and Agricultural Organization (FAO proposes a three-level strategy for the implementation of the right to food on a national legislative level, namely through: constitutional recognition, the implementation of a food framework law and the reviewing of relevant sectoral legislation. This contribution focuses on the last level of legislative provisioning, namely the reviewing of relevant sectoral legislation which influences, or possibly can, influence the realisation of the right to access to sufficient food. The right to access to sufficient food has multidimensional, interdisciplinary and cross-sectoral characteristics and consequently various sectors are involved in the realisation of the right to access to sufficient food. The FAO determines that the intended purpose will be to identify and review all sectoral legislation that might influence the availability, stability, access and adequacy of food, by means of a proposed reviewing process. The suggested reviewing process of the FAO is comprehensive and diverse; therefore the focus of this contribution is based on the reviewing of relevant environmental-related legislation only. The FAO does not make recommendations with regard to the specific aspects that need to be incorporated in environmental-related legislation to contribute to the progressive realisation of the right to access to sufficient food (in other words the aspects against which environmental-related legislation can be evaluated. Therefore this

  17. Essays in applied microeconomics

    Science.gov (United States)

    Davis, Lucas William

    2005-11-01

    The first essay measures the impact of an outbreak of pediatric leukemia on local housing values. A model of residential location choice is used to describe conditions under which the gradient of the hedonic price function with respect to health risk is equal to household marginal willingness to pay to avoid pediatric leukemia risk. This equalizing differential is estimated using property-level sales records from a county in Nevada where residents have recently experienced a severe increase in pediatric leukemia. Housing values are compared before and after the increase with a nearby county acting as a control group. The results indicate that housing values decreased 15.6% during the period of maximum risk. Results are similar for alternative measures of risk and across houses of different sizes. With risk estimates derived using a Bayesian learning model the results imply a statistical value of pediatric leukemia of $5.6 million. The results from the paper provide some of the first market-based estimates of the value of health for children. The second essay evaluates the cost-effectiveness of public incentives that encourage households to purchase high-efficiency durable goods. The demand for durable goods and the demand for energy and other inputs are modeled jointly as the solution to a household production problem. The empirical analysis focuses on the case of clothes washers. The production technology and utilization decision are estimated using household-level data from field trials in which participants received front-loading clothes washers free of charge. The estimation strategy exploits this quasi-random replacement of washers to derive robust estimates of the utilization decision. The results indicate a price elasticity, -.06, that is statistically different from zero across specifications. The parameters from the utilization decision are used to estimate the purchase decision using data from the Consumer Expenditure Survey, 1994-2002. Households

  18. Is it sufficient to repeat LINEAR accelerator stereotactic radiosurgery in choroidal melanoma?

    Science.gov (United States)

    Furdova, A; Horkovicova, K; Justusova, P; Sramka, M

    One day session LINAC based stereotactic radiosurgery (SRS) at LINAC accelerator is a method of "conservative" attitude to treat the intraocular malignant uveal melanoma. We used model Clinac 600 C/D Varian (system Aria, planning system Corvus version 6.2 verification IMRT OmniPro) with 6 MeV X by rigid immobilization of the eye to the Leibinger frame. The stereotactic treatment planning after fusion of CT and MRI was optimized according to the critical structures (lens, optic nerve, also lens and optic nerve at the contralateral side, chiasm). The first plan was compared and the best plan was applied for therapy at C LINAC accelerator. The planned therapeutic dose was 35.0 Gy by 99 % of DVH (dose volume histogram). In our clinical study in the group of 125 patients with posterior uveal melanoma treated with SRS, in 2 patients (1.6 %) was repeated SRS indicated. Patient age of the whole group ranged from 25 to 81 years with a median of 54 TD was 35.0 Gy. In 2 patients after 5 year interval after stereotactic radiosurgery for uveal melanoma stage T1, the tumor volume increased to 50 % of the primary tumor volume and repeated SRS was necessary. To find out the changes in melanoma characteristics after SRS in long term interval after irradiation is necessary to follow up the patient by an ophthalmologist regularly. One step LINAC based stereotactic radiosurgery with a single dose 35.0 Gy is one of treatment options to treat T1 to T3 stage posterior uveal melanoma and to preserve the eye globe. In some cases it is possible to repeat the SRS after more than 5 year interval (Fig. 8, Ref. 23).

  19. Lessons learned in the implementation of Integrated Safety Management at DOE Order Compliance Sites vs Necessary and Sufficient Sites

    International Nuclear Information System (INIS)

    Hill, R.L.

    2000-01-01

    This paper summarizes the development and implementation of Integrated Safety Management (ISM) at an Order Compliance Site (Savannah River Site) and a Necessary and Sufficient Site (Nevada Test Site). A discussion of each core safety function of ISM is followed by an example from an Order Compliance Site and a Necessary and Sufficient Site. The Savannah River Site was the first DOE site to have a DOE Headquarters-validated and approved ISM System. The NTS is beginning the process of verification and validation. This paper defines successful strategies for integrating Environment, Safety, and Health management into work under various scenarios

  20. Applied Linguistics and the "Annual Review of Applied Linguistics."

    Science.gov (United States)

    Kaplan, Robert B.; Grabe, William

    2000-01-01

    Examines the complexities and differences involved in granting disciplinary status to the role of applied linguistics, discusses the role of the "Annual Review of Applied Linguistics" as a contributor to the development of applied linguistics, and highlights a set of publications for the future of applied linguistics. (Author/VWL)