WorldWideScience

Sample records for chemical safety ipcs

  1. Chemical variations observed in irradiated, treated with IPC and control potato tubers; Variaciones quimica observadas en tuberculos de patata irradiados, tratados con IPC y testigo

    Energy Technology Data Exchange (ETDEWEB)

    Mazon Matanzo, M. P.; Fernandez Gonzalez, J.

    1976-07-01

    The content in soluble sugars, ascorbic acid and phenolic acids of potato tubers preserved by irradiation and IPC, during storage period of five months are studied. In the irradiated tubers, soluble sugars increased immediately after the irradiation, in relation to the control tubers reaching inferior values to those reached by the control tubers, at the end of the storage period. The content in ascorbic acid is generally kept higher in the irradiated and IPC treated tubers than in the control tubers and the content in phenolic acids increased in the irradiated and IPC treated tubers by immediate effect of this treatment. (Author) 39 refs.

  2. ILO activities in the area of chemical safety.

    Science.gov (United States)

    Obadia, Isaac

    2003-08-21

    The ILO has been active in the area of safety in the use of chemicals at work since the year of its creation in 1919, including the development of international treaties and other technical instruments, the provision of technical assistance to its member States, and the development of chemical safety information systems. The two key ILO standards in this area are the Conventions on safety in the use of chemicals at work (No. 170, 1990), and the Prevention of Major Industrial Accidents (No. 174, 1993). The ILO Programme on occupational safety, health and environment (Safe Work) is currently responsible for ILO chemical safety activities. In the past two decades, most of ILO work in this area has been carried out within the context of inter-agency collaboration frameworks linking the ILO, WHO, UNEP, FAO, UNIDO, UNITAR, and the OECD, including the International Programme on Chemical Safety (IPCS), the Inter-Organisation Programme for the Sound Management of Chemicals (IOMC), and the Intergovernmental Forum on Chemical Safety (IFCS). Apart from the regular development, updating and dissemination of chemical safety information data bases such as the IPCS International Chemical Cards, the elaboration of a Globally harmonized system for the classification and labelling of Chemicals (GHS) has been the most outstanding achievement of this international collaboration on chemical safety.

  3. Chemical Safety – Introduction

    CERN Multimedia

    DG Unit

    2009-01-01

    A course of "Chemical Safety – Introduction" will be held in English on 29 May 2009, 9:30-12:00. There are some places left. If you are interested in participating, please register on the Training Catalogue. You will then receive an invitation by email.

  4. [International Chemical Safety Cards: information source on hazards caused by chemical substances].

    Science.gov (United States)

    Pakulska, Daria; Czerczak, Sławomir

    2007-01-01

    International Chemical Safety Cards (ICSC) are produced by the International Programme on Chemical Safety (IPCS) in collaboration with the European Commission and various IPCS-participating institutions in different countries. ICSCs disseminate essential information on chemicals to promote their safe production, transport and use. Application of standard terminology along with relevant criteria facilitates the comparison of risk related to different chemicals, which makes the cards a successful hazard-communication tool. Translation of the cards into various languages all over the world reflects the range of their growing use. A multi-stage compilation of information contained in ICSCs, based on the most up-to-date world literature and professional databases, assures its reliability. Their concise form makes them easy in everyday use as a source of information on chemical safety. The range of information contained in ICSCs corresponds to that provided by Material Safety Data Sheets (MSDS), however, the former are more concise and simpler. Although ICSCs have no legal status they may complement a 16-point MSDSs and help in the implementation of labeling and classification of chemicals according to the Globally Harmonized System.

  5. chemical safety and chemical security overview

    African Journals Online (AJOL)

    IICBA01

    expert in chemical security and work hard to safeguard the communities. Items discussed in this ... the public from injury, fire or other damage. In order to achieve these ..... 10.8 Transportation of hazardous chemicals and wastes? ... Chemical Security Engagement Program: https://chemsecurity.sandia.gov/. Chemical Safety.

  6. IPC,Safe Consumption Provider

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ 2008 was a lucty year for Malaysia IPC Shopping Service International Group. Her Presi-dent, Dr. Stcwin Leow Yoon Loy was awarded "Asia-Pacific Outstanding CEO" again with his personal charisma; then IPC Shopping Services (M) Co., Lid.

  7. Chemical Hygiene and Safety Plan

    Energy Technology Data Exchange (ETDEWEB)

    Berkner, K.

    1992-08-01

    The objective of this Chemical Hygiene and Safety Plan (CHSP) is to provide specific guidance to all LBL employees and contractors who use hazardous chemicals. This Plan, when implemented, fulfills the requirements of both the Federal OSHA Laboratory Standard (29 CFR 1910.1450) for laboratory workers, and the Federal OSHA Hazard Communication Standard (29 CFR 1910.1200) for non-laboratory operations (e.g., shops). It sets forth safety procedures and describes how LBL employees are informed about the potential chemical hazards in their work areas so they can avoid harmful exposures and safeguard their health. Generally, communication of this Plan will occur through training and the Plan will serve as a the framework and reference guide for that training.

  8. New set of Chemical Safety rules

    CERN Multimedia

    HSE Unit

    2011-01-01

    A new set of four Safety Rules was issued on 28 March 2011: Safety Regulation SR-C ver. 2, Chemical Agents (en); General Safety Instruction GSI-C1, Prevention and Protection Measures (en); General Safety Instruction GSI-C2, Explosive Atmospheres (en); General Safety Instruction GSI-C3, Monitoring of Exposure to Hazardous Chemical Agents in Workplace Atmospheres (en). These documents form part of the CERN Safety Rules and are issued in application of the “Staff Rules and Regulations” and of document SAPOCO 42. These documents set out the minimum requirements for the protection of persons from risks to their occupational safety and health arising, or likely to arise, from the effects of hazardous chemical agents that are present in the workplace or used in any CERN activity. Simultaneously, the HSE Unit has published seven Safety Guidelines and six Safety Forms. These documents are available from the dedicated Web page “Chemical, Cryogenic and Biological Safety&...

  9. Chemical Safety Vulnerability Working Group Report

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-01

    This report marks the culmination of a 4-month review conducted to identify chemical safety vulnerabilities existing at DOE facilities. This review is an integral part of DOE's efforts to raise its commitment to chemical safety to the same level as that for nuclear safety.

  10. Experiments To Demonstrate Chemical Process Safety Principles.

    Science.gov (United States)

    Dorathy, Brian D.; Mooers, Jamisue A.; Warren, Matthew M.; Mich, Jennifer L.; Murhammer, David W.

    2001-01-01

    Points out the need to educate undergraduate chemical engineering students on chemical process safety and introduces the content of a chemical process safety course offered at the University of Iowa. Presents laboratory experiments demonstrating flammability limits, flash points, electrostatic, runaway reactions, explosions, and relief design.…

  11. New Safety rule for Chemical Agents

    CERN Multimedia

    Safety Commission

    2010-01-01

    The following Safety rule has been issued on 08-01-2010: Safety Regulation SR-C Chemical Agents This document applies to all persons under the Director General’s authority. It sets out the minimal requirements for the protection of persons from risks to their safety and health arising, or likely to arise, from the effects of hazardous chemical agents used in any CERN activity. All Safety rules are available on the web pages.

  12. Engineering Benchmarks for Planning: the Domains Used in the Deterministic Part of IPC-4

    CERN Document Server

    Edelkamp, S; Hoffmann, J; Liporace, F; Thiebaux, S; Trueg, S; 10.1613/jair.1982

    2011-01-01

    In a field of research about general reasoning mechanisms, it is essential to have appropriate benchmarks. Ideally, the benchmarks should reflect possible applications of the developed technology. In AI Planning, researchers more and more tend to draw their testing examples from the benchmark collections used in the International Planning Competition (IPC). In the organization of (the deterministic part of) the fourth IPC, IPC-4, the authors therefore invested significant effort to create a useful set of benchmarks. They come from five different (potential) real-world applications of planning: airport ground traffic control, oil derivative transportation in pipeline networks, model-checking safety properties, power supply restoration, and UMTS call setup. Adapting and preparing such an application for use as a benchmark in the IPC involves, at the time, inevitable (often drastic) simplifications, as well as careful choice between, and engineering of, domain encodings. For the first time in the IPC, we used co...

  13. Chemical Safety Alert: Identifying Chemical Reactivity Hazards Preliminary Screening Method

    Science.gov (United States)

    Introduces small-to-medium-sized facilities to a method developed by Center for Chemical Process Safety (CCPS), based on a series of twelve yes-or-no questions to help determine hazards in warehousing, repackaging, blending, mixing, and processing.

  14. Emissie van Chloor-IPC uit aardappelbewaarplaatsen

    NARCIS (Netherlands)

    Bos, D.; Schans, van der D.A.; Mosquera Losada, J.

    2005-01-01

    Per jaar wordt naar schatting 40.000 kg actieve stof Chloor-IPC toegepast als kiemremmingsmiddel van aardappelen. Chloor-IPC is een stof die makkelijk verdampt en weer christalliseert. Waar deze stof na toediening blijft is niet bekend. Het doel van het onderzoek was na te gaan of puntemissies optre

  15. IPC-4101D修改内容简介

    Institute of Scientific and Technical Information of China (English)

    蔡巧儿

    2015-01-01

    IPC-4101D《刚性及多层印制板用基材规范》于2014年4月正式发布,这里简单介绍IPC-4101D中主要修改内容。IPC-4101D主要修改内容包括以下几点:1.IPC-4101D新增6个规格单,删除8个规格单(见表1)。IPC4101D中新增的6个规格单包括:IPC-4101/34、IPC-4101/34、IPC-4101/43、IPC-4101/44、IPC-4101/72、IPC-4101/73。删除的8个规格单包括:IPC-4101/28、IPC-4101/54、IPC-4101/82、IPC-4101/83、IPC-4101/92、IPC-4101/93、IPC-4101/94IPC-4101/95。

  16. Process safety management for highly hazardous chemicals

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    Purpose of this document is to assist US DOE contractors who work with threshold quantities of highly hazardous chemicals (HHCs), flammable liquids or gases, or explosives in successfully implementing the requirements of OSHA Rule for Process Safety Management of Highly Hazardous Chemicals (29 CFR 1910.119). Purpose of this rule is to prevent releases of HHCs that have the potential to cause catastrophic fires, explosions, or toxic exposures.

  17. TUNED IPC WITH TWO DEGREES OF FREEDOM

    Directory of Open Access Journals (Sweden)

    Kalinin L.P.

    2006-04-01

    Full Text Available This paper introduces a new family of IPC-UPFC combination for independent control of active and reactive output power, the control strategy is presented to maintain the required power characteristics.

  18. Animal-Free Chemical Safety Assessment

    Directory of Open Access Journals (Sweden)

    George D Loizou

    2016-07-01

    Full Text Available The exponential growth of the Internet of Things and the global popularity and remarkable decline in cost of the mobile phone is driving the digital transformation of medical practice. The rapidly maturing digital, nonmedical world of mobile (wireless devices, cloud computing and social networking is coalescing with the emerging digital medical world of omics data, biosensors and advanced imaging which offers the increasingly realistic prospect of personalized medicine. Described as a potential seismic shift from the current healthcare model to a wellness paradigm that is predictive, preventative, personalized and participatory, this change is based on the development of increasingly sophisticated biosensors which can track and measure key biochemical variables in people. Additional key drivers in this shift are metabolomic and proteomic signatures, which are increasingly being reported as pre-symptomatic, diagnostic and prognostic of toxicity and disease. These advancements also have profound implications for toxicological evaluation and safety assessment of pharmaceuticals and environmental chemicals. An approach based primarily on human in vivo and high-throughput in vitro human cell-line data is a distinct possibility. This would transform current chemical safety assessment practise which operates in a human data poor to a human data rich environment. This could also lead to a seismic shift from the current animal-based to an animal-free chemical safety assessment paradigm.

  19. Animal-Free Chemical Safety Assessment.

    Science.gov (United States)

    Loizou, George D

    2016-01-01

    The exponential growth of the Internet of Things and the global popularity and remarkable decline in cost of the mobile phone is driving the digital transformation of medical practice. The rapidly maturing digital, non-medical world of mobile (wireless) devices, cloud computing and social networking is coalescing with the emerging digital medical world of omics data, biosensors and advanced imaging which offers the increasingly realistic prospect of personalized medicine. Described as a potential "seismic" shift from the current "healthcare" model to a "wellness" paradigm that is predictive, preventative, personalized and participatory, this change is based on the development of increasingly sophisticated biosensors which can track and measure key biochemical variables in people. Additional key drivers in this shift are metabolomic and proteomic signatures, which are increasingly being reported as pre-symptomatic, diagnostic and prognostic of toxicity and disease. These advancements also have profound implications for toxicological evaluation and safety assessment of pharmaceuticals and environmental chemicals. An approach based primarily on human in vivo and high-throughput in vitro human cell-line data is a distinct possibility. This would transform current chemical safety assessment practice which operates in a human "data poor" to a human "data rich" environment. This could also lead to a seismic shift from the current animal-based to an animal-free chemical safety assessment paradigm.

  20. IPC synthase as a useful target for antifungal drugs.

    Science.gov (United States)

    Sugimoto, Yuichi; Sakoh, Hiroki; Yamada, Koji

    2004-12-01

    Inositol phosphorylceramide (IPC) synthase is a common and essential enzyme in fungi and plants, which catalyzes the transfer of phosphoinositol to the C-1 hydroxy of ceramide to produce IPC. This reaction is a key step in fungal sphingolipid biosynthesis, therefore the enzyme is a potential target for the development of nontoxic therapeutic antifungal agents. Natural products with a desired biological activity, aureobasidin A (AbA), khafrefungin, and galbonolide A, have been reported. AbA, a cyclic depsipeptide containing 8 amino acids and a hydroxyl acid, is a broad spectrum antifungal with strong activity against many pathogenic fungi such as Candida spp., Cryptococcus neoformans, and some Aspergillus spp. Khafrefungin, an aldonic acid ester with a C22 long alkyl chain, has antifungal activity against C. albicans, Cr. Neoformans, and Saccharomyces cerevisiae. Galbonolide A is a 14-membered macrolide with fungicidal activity against clinically important strains, and is especially potent against Cr. neoformans. These classes of natural products are potent and specific antifungal agents. We review current progress in the development of IPC synthase inhibitors with antifungal activities, and present structure-activity relationships (SAR), physicochemical and structural properties, and synthetic methodology for chemical modification.

  1. Chemical safety of meat and meat products.

    Science.gov (United States)

    Andrée, Sabine; Jira, W; Schwind, K-H; Wagner, H; Schwägele, F

    2010-09-01

    Since the Second World War the consumer behaviour in developed countries changed drastically. Primarily there existed the demand for sufficient food after a period of starvation, afterwards the desire for higher quality was arising, whereas today most people ask for safe and healthy food with high quality. Therefore a united approach comprising consistent standards, sound science and robust controls is required to ensure consumers' health and to maintain consumers' confidence and satisfaction. Chemical analysis along the whole food chain downstream (tracking) from primary production to the consumer and upstream (tracing) from the consumer to primary production is an important prerequisite to ensure food safety and quality. In this frame the focus of the following paper is the "chemical safety of meat and meat products" taking into account inorganic as well as organic residues and contaminants, the use of nitrite in meat products, the incidence of veterinary drugs, as well as a Failure Mode and Effect Analysis (FMEA) system assessing (prioritizing) vulnerable food chain steps to decrease or eliminate vulnerability.

  2. Using game theory to improve safety within chemical industrial parks

    CERN Document Server

    Reniers, Genserik

    2013-01-01

    Though the game-theoretic approach has been vastly studied and utilized in relation to economics of industrial organizations, it has hardly been used to tackle safety management in multi-plant chemical industrial settings. Using Game Theory for Improving Safety within Chemical Industrial Parks presents an in-depth discussion of game-theoretic modelling which may be applied to improve cross-company prevention and -safety management in a chemical industrial park.   By systematically analyzing game-theoretic models and approaches in relation to managing safety in chemical industrial parks, Using Game Theory for Improving Safety within Chemical Industrial Parks explores the ways game theory can predict the outcome of complex strategic investment decision making processes involving several adjacent chemical plants. A number of game-theoretic decision models are discussed to provide strategic tools for decision-making situations.   Offering clear and straightforward explanations of methodologies, Using Game Theor...

  3. Chemical Safety Vulnerability Working Group report. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-01

    The Chemical Safety Vulnerability (CSV) Working Group was established to identify adverse conditions involving hazardous chemicals at DOE facilities that might result in fires or explosions, release of hazardous chemicals to the environment, or exposure of workers or the public to chemicals. A CSV Review was conducted in 148 facilities at 29 sites. Eight generic vulnerabilities were documented related to: abandoned chemicals and chemical residuals; past chemical spills and ground releases; characterization of legacy chemicals and wastes; disposition of legacy chemicals; storage facilities and conditions; condition of facilities and support systems; unanalyzed and unaddressed hazards; and inventory control and tracking. Weaknesses in five programmatic areas were also identified related to: management commitment and planning; chemical safety management programs; aging facilities that continue to operate; nonoperating facilities awaiting deactivation; and resource allocations. Volume 1 contains the Executive summary; Introduction; Summary of vulnerabilities; Management systems weaknesses; Commendable practices; Summary of management response plan; Conclusions; and a Glossary of chemical terms.

  4. Chemical Safety Vulnerability Working Group report. Volume 3

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-01

    The Chemical Safety Vulnerability (CSV) Working Group was established to identify adverse conditions involving hazardous chemicals at DOE facilities that might result in fires or explosions, release of hazardous chemicals to the environment, or exposure of workers or the public to chemicals. A CSV Review was conducted in 148 facilities at 29 sites. Eight generic vulnerabilities were documented related to: abandoned chemicals and chemical residuals; past chemical spills and ground releases; characterization of legacy chemicals and wastes; disposition of legacy chemicals; storage facilities and conditions; condition of facilities and support systems; unanalyzed and unaddressed hazards; and inventory control and tracking. Weaknesses in five programmatic areas were also identified related to: management commitment and planning; chemical safety management programs; aging facilities that continue to operate; nonoperating facilities awaiting deactivation; and resource allocations. Volume 3 consists of eleven appendices containing the following: Field verification reports for Idaho National Engineering Lab., Rocky Flats Plant, Brookhaven National Lab., Los Alamos National Lab., and Sandia National Laboratories (NM); Mini-visits to small DOE sites; Working Group meeting, June 7--8, 1994; Commendable practices; Related chemical safety initiatives at DOE; Regulatory framework and industry initiatives related to chemical safety; and Chemical inventory data from field self-evaluation reports.

  5. Idaho Chemical Processing Plant safety document ICPP hazardous chemical evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Harwood, B.J.

    1993-01-01

    This report presents the results of a hazardous chemical evaluation performed for the Idaho Chemical Processing Plant (ICPP). ICPP tracks chemicals on a computerized database, Haz Track, that contains roughly 2000 individual chemicals. The database contains information about each chemical, such as its form (solid, liquid, or gas); quantity, either in weight or volume; and its location. The Haz Track database was used as the primary starting point for the chemical evaluation presented in this report. The chemical data and results presented here are not intended to provide limits, but to provide a starting point for nonradiological hazards analysis.

  6. Database for Safety-Oriented Tracking of Chemicals

    Science.gov (United States)

    Stump, Jacob; Carr, Sandra; Plumlee, Debrah; Slater, Andy; Samson, Thomas M.; Holowaty, Toby L.; Skeete, Darren; Haenz, Mary Alice; Hershman, Scot; Raviprakash, Pushpa

    2010-01-01

    SafetyChem is a computer program that maintains a relational database for tracking chemicals and associated hazards at Johnson Space Center (JSC) by use of a Web-based graphical user interface. The SafetyChem database is accessible to authorized users via a JSC intranet. All new chemicals pass through a safety office, where information on hazards, required personal protective equipment (PPE), fire-protection warnings, and target organ effects (TOEs) is extracted from material safety data sheets (MSDSs) and recorded in the database. The database facilitates real-time management of inventory with attention to such issues as stability, shelf life, reduction of waste through transfer of unused chemicals to laboratories that need them, quantification of chemical wastes, and identification of chemicals for which disposal is required. Upon searching the database for a chemical, the user receives information on physical properties of the chemical, hazard warnings, required PPE, a link to the MSDS, and references to the applicable International Standards Organization (ISO) 9000 standard work instructions and the applicable job hazard analysis. Also, to reduce the labor hours needed to comply with reporting requirements of the Occupational Safety and Health Administration, the data can be directly exported into the JSC hazardous- materials database.

  7. Chemical Safety Alert: Chemical Accidents from Electric Power Outages

    Science.gov (United States)

    Incident data from the National Response Center (NRC) shows that during 2000 there were about 240 chemical releases reported due to an electric power interruption, as well as resumption/restart; only a few were related to planned rolling blackouts.

  8. Safety in the Chemical Laboratory: Flood Control.

    Science.gov (United States)

    Pollard, Bruce D.

    1983-01-01

    Describes events leading to a flood in the Wehr Chemistry Laboratory at Marquette University, discussing steps taken to minimize damage upon discovery. Analyzes the problem of flooding in the chemical laboratory and outlines seven steps of flood control: prevention; minimization; early detection; stopping the flood; evaluation; clean-up; and…

  9. Chemical Safety Vulnerability Working Group report. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-01

    The Chemical Safety Vulnerability (CSV) Working Group was established to identify adverse conditions involving hazardous chemicals at DOE facilities that might result in fires or explosions, release of hazardous chemicals to the environment, or exposure of workers or the public to chemicals. A CSV Review was conducted in 148 facilities at 29 sites. Eight generic vulnerabilities were documented related to: abandoned chemicals and chemical residuals; past chemical spills and ground releases; characterization of legacy chemicals and wastes; disposition of legacy chemicals; storage facilities and conditions; condition of facilities and support systems; unanalyzed and unaddressed hazards; and inventory control and tracking. Weaknesses in five programmatic areas were also identified related to: management commitment and planning; chemical safety management programs; aging facilities that continue to operate; nonoperating facilities awaiting deactivation; and resource allocations. Volume 2 consists of seven appendices containing the following: Tasking memorandums; Project plan for the CSV Review; Field verification guide for the CSV Review; Field verification report, Lawrence Livermore National Lab.; Field verification report, Oak Ridge Reservation; Field verification report, Savannah River Site; and the Field verification report, Hanford Site.

  10. Is delayed ischemic preconditioning as effective on running performance during a 5km time trial as acute IPC?

    Science.gov (United States)

    Seeger, Joost P H; Timmers, Silvie; Ploegmakers, Danique J M; Cable, N Timothy; Hopman, Maria T E; Thijssen, Dick H J

    2017-02-01

    Ischemic preconditioning (IPC) may enhance exercise performance. Cardioprotective effects of IPC are known to re-occur 24h after the stimulus. Whether the delayed effect of IPC has similar effects as IPC on exercise performance is unknown.

  11. A chiral alkyltris(pyrazolyl)borate ligand: synthesis of [(Ipc)B(pz)3Mn(CO)3] and [(Ipc)B(pz)3Ru(p-cymene)]PF6 (Ipc = Isopinocampheyl).

    Science.gov (United States)

    Bailey, Philip J; Pinho, Pedro; Parsons, Simon

    2003-12-29

    The application of the reagent (Ipc)BCl(2) (Ipc = isopinocampheyl) in the synthesis of a new tris(pyrazolyl)borate ligand having an Ipc substituent on boron is described. The sodium salt is a convenient precursor for the preparation of the complexes [(Ipc)tris(pyrazolyl)borato]tricarbonylmanganese and [[(Ipc)tris(pyrazolyl)borato](p-cymene)ruthenium](+), whose X-ray crystal structures are reported. While little distortion of the B(pz)(3)M unit is observed in these complexes, steric interaction between the Ipc group and the 3-positions of the pyrazolyl rings is noted to lead to distortion of the angles around the B-C bond.

  12. Relationship of green chemistry and chemical environment safety management

    Institute of Scientific and Technical Information of China (English)

    NieJL; ShenYW

    2002-01-01

    Green chemistry and chemical environmental safety management are the two important techniques and management means to implement sustainable development policy.They are also the two basic tools to carry out headstream depollution and environmental protection.This paper reviewed the principle of green chemistry and main contents of chemical environment safety management from the point of management toxicity,pointed out the same aim of these two techniques and management measures,and described the foreground of those two sustainable development environmental methods in China.

  13. Is delayed ischemic preconditioning as effective on running performance during a 5km time trial as acute IPC?

    NARCIS (Netherlands)

    Seeger, J.P.H.; Timmers, S.; Ploegmakers, D.J.; Cable, N.T.; Hopman, M.T.E.; Thijssen, D.H.J.

    2017-01-01

    Ischemic preconditioning (IPC) may enhance exercise performance. Cardioprotective effects of IPC are known to re-occur 24h after the stimulus. Whether the delayed effect of IPC has similar effects as IPC on exercise performance is unknown. OBJECTIVES: Examine whether IPC applied 24h (24-IPC) before

  14. Early dislodgement of Indwelling Pleural Catheter (IPC): a balancing act.

    Science.gov (United States)

    Tung, Alvin Hon Man; Ngai, Jenny Chun Li; Ng, Susanna So Shan; Ko, Fanny Wai San; Hui, David Shu-Cheong

    2014-03-01

    A 63-year-old nonsmoker with right malignant pleural effusion derived symptomatic benefit following drainage of his effusion. Following insertion of indwelling pleural catheter (IPC), 1.3 L of blood-stained fluid was drained into underwater sealed bottle (Atrium®), but the IPC dislodged 26 h after continuous connection. We believe that the weight of the drainage bottle (including the un-emptied fluid) and the prolonged connection time contributed to this uncommon event reported in the literature. There was no recurrence when his second IPC was connected to a drainage bag which was emptied at every 500 mL, capped at 2 h each time. An anchoring stitch should also be considered when drainage devices heavier than the manufacturer bottles are used to drain IPC.

  15. A complete public archive for the Einstein IPC

    Science.gov (United States)

    Helfand, David J.

    1995-01-01

    This report documents progress made in the period 24 Sept. 1993 - 23 Sept. 1995 on the project described in our proposal 'A Complete Public Archive for the Einstein IPC' which was approved under the Astrophysics Data Program in 1992. We have completed most of the principal objectives of the original proposal; a NFE was recently approved so that costs for publications in press can be covered and we can complete the public record for the Einstein IPC database.

  16. Chemical Abstracts as a resource for health and safety-related chemical information.

    Science.gov (United States)

    Moody, R L; Zahm, B C

    1980-02-01

    Documents relevant to the health and safety of the worker or consumer exposed to chemicals or radiation extend over the entire range of the chemical disciplines, and therefore pertinent information can appear throughout the Chemical Abstracts Service information systems. Access routes to such information in both CAS printed publications and computer-readable services are discussed. In the weekly issues of Chemical Abstracts, health and safety information can be accessed through the natural-language Keyword Index. Retrieval of pertinent information through the controlled headings of the CA Volume Indexes in conjunction with the Index Guide is also discussed. CA Selects, a set of current-awareness publications, is described as it pertains to the specialized areas of health and safety.

  17. PROVIDING INDUSTRIAL SAFETY IN THE DESIGN OF CHEMICAL FACILITIES

    Directory of Open Access Journals (Sweden)

    S. V. Danilova

    2015-01-01

    Full Text Available Designing of chemical destination requires developers’ particular, careful approach, as malfunctions are dangerous for the whole area in which the facility is located. Efficient and uninterrupted operation of a chemical entity assumes certain tasks, and at the design stage, and during the construction, reconstruction, repair, and maintenance. When designing a crucial question: placing equipment in the technological scheme (nature and the order and connection of separate devices; determine the input parameters of raw materials; establishment of technological parameters of the system; determine the structural characteristics of the devices of the system; selection of process parameters in devices that affect the speed of the process, output and product quality. The main document containing the requirements of industrial safety, chemical and other dangerous objects is the Federal Law of July 21, 1997 № 116-FZ "On industrial safety of hazardous production facilities", as amended on December 31, 2014. It defines and regulates the framework for ensuring the safe operation of hazardous production facilities. The most important part in the development and design of hazardous chemicals is the examination of industrial safety, which is held on the basis of the principles of independence, objectivity, comprehensiveness and completeness of the research carried out by using modern science and technology. Design of chemical facilities is a complex, multifactorial and time-consuming process, which should be regarded as a series of socio-organizational and engineering stages. It is a systematic approach to solving design problems and control of all stages of the life cycle of chemical facilities will provide a high level of safe operation of industrial facilities.

  18. Probabilistic safety assessment in the chemical and nuclear industries

    CERN Document Server

    Fullwood, Ralph R

    2000-01-01

    Probabilistic Safety Analysis (PSA) determines the probability and consequences of accidents, hence, the risk. This subject concerns policy makers, regulators, designers, educators and engineers working to achieve maximum safety with operational efficiency. Risk is analyzed using methods for achieving reliability in the space program. The first major application was to the nuclear power industry, followed by applications to the chemical industry. It has also been applied to space, aviation, defense, ground, and water transportation. This book is unique in its treatment of chemical and nuclear risk. Problems are included at the end of many chapters, and answers are in the back of the book. Computer files are provided (via the internet), containing reliability data, a calculator that determines failure rate and uncertainty based on field experience, pipe break calculator, event tree calculator, FTAP and associated programs for fault tree analysis, and a units conversion code. It contains 540 references and many...

  19. Process Control Systems in the Chemical Industry: Safety vs. Security

    Energy Technology Data Exchange (ETDEWEB)

    Jeffrey Hahn; Thomas Anderson

    2005-04-01

    Traditionally, the primary focus of the chemical industry has been safety and productivity. However, recent threats to our nation’s critical infrastructure have prompted a tightening of security measures across many different industry sectors. Reducing vulnerabilities of control systems against physical and cyber attack is necessary to ensure the safety, security and effective functioning of these systems. The U.S. Department of Homeland Security has developed a strategy to secure these vulnerabilities. Crucial to this strategy is the Control Systems Security and Test Center (CSSTC) established to test and analyze control systems equipment. In addition, the CSSTC promotes a proactive, collaborative approach to increase industry's awareness of standards, products and processes that can enhance the security of control systems. This paper outlines measures that can be taken to enhance the cybersecurity of process control systems in the chemical sector.

  20. Interpersonal Counseling (IPC) for Depression in Primary Care.

    Science.gov (United States)

    Weissman, Myrna M; Hankerson, Sidney H; Scorza, Pamela; Olfson, Mark; Verdeli, Helena; Shea, Steven; Lantigua, Rafael; Wainberg, Milton

    2014-01-01

    Interpersonal Counseling (IPC) comes directly from interpersonal psychotherapy (IPT), an evidenced-based psychotherapy developed by Klerman and Weissman. It [IPC?] is a briefer, more structured version for use primarily in non-mental health settings, such as primary care clinics when treating patients with symptoms of depression. National health-care reform, which will bring previously uninsured persons into care and provide mechanisms to support mental health training of primary care providers, will increase interest in briefer psychotherapy. This paper describes the rationale, development, evidence for efficacy, and basic structure of IPC and also presents an illustrated clinical vignette. The evidence suggests that IPC is efficacious in reducing symptoms of depression; that it can be used by mental health personnel of different levels of training, and that the number of sessions is flexible depending on the context and resources. More clinical trials are needed, especially ones comparing IPC to other types of care used in the delivery of mental health services in primary care.

  1. The Deterministic Part of IPC-4: An Overview

    CERN Document Server

    Edelkamp, S; 10.1613/jair.1677

    2011-01-01

    We provide an overview of the organization and results of the deterministic part of the 4th International Planning Competition, i.e., of the part concerned with evaluating systems doing deterministic planning. IPC-4 attracted even more competing systems than its already large predecessors, and the competition event was revised in several important respects. After giving an introduction to the IPC, we briefly explain the main differences between the deterministic part of IPC-4 and its predecessors. We then introduce formally the language used, called PDDL2.2 that extends PDDL2.1 by derived predicates and timed initial literals. We list the competing systems and overview the results of the competition. The entire set of data is far too large to be presented in full. We provide a detailed summary; the complete data is available in an online appendix. We explain how we awarded the competition prizes.

  2. Chemical reactivity evaluation: The CCPS program. [CCPS (Center for Chemical Process Safety)

    Energy Technology Data Exchange (ETDEWEB)

    West, A.S. (American Institute of Chemical Engineers, New York, NY (United States))

    1993-01-01

    A summary is presented of the chemical reactivity evaluation aspects of the soon to be published [open quotes]Guidelines for Chemical Reactivity Evaluation and Application to Process Design[close quotes] developed under the sponsorship of the Center for Chemical Process Safety. Emphasis is placed on strategies for thermochemical evaluation of industrial chemical substances. Certain structural entities, for example, high degrees of unsaturation and nitrogen-halogen linkages, will likely identify hazardous reactive chemicals. The effects of impurities in the chemicals, as well as, for example, incidental contact with water and air (oxygen), must also be considered in the evaluation of potential reactivity hazards, representing undesired reactions. Various test methods are indicated briefly along with the rationale for use of specific methods in hazard evaluation. 30 refs., 1 fig., 9 tabs.

  3. Chemical Safety for Teachers and Their Supervisors. Grades 7-12.

    Science.gov (United States)

    American Chemical Society, Washington, DC.

    This booklet contains information and guidelines for the safe use and handling of chemicals in laboratories and student classrooms. The theme of this handbook is prevention of accidents with chemicals which involves chemical knowledge and the habit of safety. Topics include: (1) safety in the use and handling of hazardous chemicals; (2) teaching…

  4. [Non-animal toxicology in the safety testing of chemicals].

    Science.gov (United States)

    Heinonen, Tuula; Tähti, Hanna

    2013-01-01

    There is an urgent need to develop predictive test methods better than animal experiments for assessing the safety of chemical substances to man. According to today's vision this is achieved by using human cell based tissue and organ models. In the new testing strategy the toxic effects are assessed by the changes in the critical parameters of the cellular biochemical routes (AOP, adverse toxic outcome pathway-principle) in the target tissues. In vitro-tests are rapid and effective, and with them automation can be applied. The change in the testing paradigm is supported by all stakeholders: scientists, regulators and people concerned on animal welfare.

  5. Intraperitoneal chemotherapy (IPC) for peritoneal carcinomatosis: review of animal models.

    Science.gov (United States)

    Gremonprez, Félix; Willaert, Wouter; Ceelen, Wim

    2014-02-01

    The development of suitable animal models is essential to experimental research on intraperitoneal chemotherapy (IPC). This review of the English literature (MEDLINE) presents a detailed analysis of current animal models and gives recommendations for future experimental research. Special consideration should be given to cytotoxic drug dose and concentration, tumor models, and outcome parameters.

  6. IPC-4101A《刚性及多层印制板基材规范》介绍%Introduction of IPC-4101A Specification for Base Material for Rigid and Multilayer Printed Board

    Institute of Scientific and Technical Information of China (English)

    高艳茹

    2001-01-01

    @@ 1997年12月,IPC颁布的IPG-4101,取代了IPC相关的五个规范(IPC-L-108、IPC-L-109、IPC-L-112、IPC-L-115、IPC-AM-360),最近IPC又提出了IPC4101A-2000讨论稿,该标准拟代替1997年版的IPC-4101A,为了便于同行了解IPC-4101A的内容,将该标准涉及的详细规范简要介绍如下.

  7. [Formation mechanism and chemical safety of nonintentional chemical substances present in chlorinated drinking water and wastewater].

    Science.gov (United States)

    Onodera, Sukeo

    2010-09-01

    This paper reviews the formation mechanism and chemical safety of nonintentional chemical substances (NICS) present in chlorine-treated water containing organic contaminants. Undesirable compounds, i.e., NICS, may be formed under certain conditions when chlorine reacts with organic matter. The rate and extent of chlorine consumption with organics are strongly dependent on their chemical structures, particularly whether double bonds or sulfur and nitrogen atoms occur in the molecules. Organothiophosphorus pesticides (P=S type) are easily oxidized to their phosphorus compounds (P=O type) in chlorinated water containing HOCl as little as 0.5 mg/l, resulting in an increase in cholinesterase-inhibitory activity. Chlorination of phenols in water also produces a series of highly chlorinated compounds, including chlorophenols, chloroquinones, chlorinated carboxylic acids, and polychlorinated phenoxyphenols (PCPPs). In some of these chloroquinones, 2,6-dichloroalkylsemiquinones exhibit a strong mutagenic response as do positive controls used in the Ames test. 2-phenoxyphenols in these PCPPs are particularly interesting, as they are present in the chlorine-treated phenol solution and they are also precursors (predioxins) of the highly toxic chlorinated dioxins. Polynuclear aromatic hydrocarbons (PAHs) were found to undergo chemical changes due to hypochlorite reactions to give chloro-substituted PAHs, oxygenated (quinones) and hydroxylated (phenols) compounds, but they exhibit a lower mutagenic response. In addition, field work was performed in river water and drinking water to obtain information on chemical distribution and their safety, and the results are compared with those obtained in the model chlorination experiments.

  8. Release mitigation spray safety systems for chemical demilitarization applications.

    Energy Technology Data Exchange (ETDEWEB)

    Leonard, Jonathan; Tezak, Matthew Stephen; Brockmann, John E.; Servantes, Brandon; Sanchez, Andres L.; Tucker, Mark David; Allen, Ashley N.; Wilson, Mollye C.; Lucero, Daniel A.; Betty, Rita G.

    2010-06-01

    Sandia National Laboratories has conducted proof-of-concept experiments demonstrating effective knockdown and neutralization of aerosolized CBW simulants using charged DF-200 decontaminant sprays. DF-200 is an aqueous decontaminant, developed by Sandia National Laboratories, and procured and fielded by the US Military. Of significance is the potential application of this fundamental technology to numerous applications including mitigation and neutralization of releases arising during chemical demilitarization operations. A release mitigation spray safety system will remove airborne contaminants from an accidental release during operations, to protect personnel and limit contamination. Sandia National Laboratories recently (November, 2008) secured funding from the US Army's Program Manager for Non-Stockpile Chemical Materials Agency (PMNSCMA) to investigate use of mitigation spray systems for chemical demilitarization applications. For non-stockpile processes, mitigation spray systems co-located with the current Explosive Destruction System (EDS) will provide security both as an operational protective measure and in the event of an accidental release. Additionally, 'tented' mitigation spray systems for native or foreign remediation and recovery operations will contain accidental releases arising from removal of underground, unstable CBW munitions. A mitigation spray system for highly controlled stockpile operations will provide defense from accidental spills or leaks during routine procedures.

  9. 2009 IPC Works Asia 2009精彩谢幕

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    近日,2009年IPC一国际电子工业联接协会在深圳圣廷苑酒店举办了IPC Works Asia 2009系列技术活动,为陷于金融危机水深火热之中的中国电子行业带来一次振奋人心的技术盛会。会议期间融汇了技术研讨会、IPC TGAsia标;隹开发会议、IPC中国OEM理事会会议、IPC SPVC理事会会议、IPC会员交流联谊会等精彩活动。其中,作为关键环节的技术研讨会,专注于环保、电子组装和测试,得到了业界的广泛关注和好评。

  10. Safety evaluation of chemical mixtures and combinations of chemical and non-chemical stressors

    NARCIS (Netherlands)

    Jonker, D.; Freidig, A.P.; Groten, J.P.; Hollander, A.E.M.de; Stierum, R.H.; Woutersen, R.A.; Feron, V.J.

    2004-01-01

    Recent developments in hazard identification and risk assessment of chemical mixtures are reviewed. Empirical, descriptive approaches to study and characterize the toxicity of mixtures have dominated during the past two decades, but an increasing number of mechanistic approaches have made their entr

  11. Existing chemicals: international activities.

    Science.gov (United States)

    Purchase, J F

    1989-01-01

    The standards of care used in the protection of the health and safety of people exposed to chemicals has increased dramatically in the last decade. Standards imposed by regulation and those adopted by industry have required a greater level of knowledge about the hazards of chemicals. In the E.E.C., the 6th amendment of the dangerous substances directive imposed the requirement that al new chemicals should be tested according to prescribed programme before introduction on to the market. The development of a European inventory of existing chemicals was an integral part of the 6th amendment. It has now become clear that increased standards of care referred to above must be applied to the chemicals on the inventory list. There is, however, a considerable amount of activity already under way in various international agencies. The OECD Chemicals Programme has been involved in considering the problem of existing chemicals for some time, and is producing a priority list and action programme. The International Programme on Chemical Safety produces international chemical safety cards, health and safety guides and environmental health criteria documents. The international register of potentially toxic compounds (part of UNEP) has prepared chemical data profiles on 990 compounds. The International Agency for Research on Cancer prepared monographs on the carcinogenic risk of chemicals to man. So far 42 volumes have been prepared covering about 900 substances. IARC and IPCS also prepare periodic reports on ongoing research on carcinogenicity or toxicity (respectively) of chemicals. The chemical industry through ECETOC (the European Chemical Industry Ecology and Toxicology Centre) has mounted a major initiative on existing chemicals. Comprehensive reviews of the toxicity of selected chemicals are published (Joint Assessment of Commodity Chemicals). In its technical report no. 30 ECETOC lists reviews and evaluations by major national and international organisations, which provides

  12. The Einstein All-Sky IPC slew survey

    Science.gov (United States)

    Elvis, Martin; Plummer, David; Fabbiano, G.

    1989-01-01

    The construction of the Einstein All-Sky Imaging Proportional Counter (IPC) slew survey is considered. It contains approximately 1000 sources between 10(exp -12) and 10(exp -10) erg/sq cm/s with a concentration toward the ecliptic poles and away from the galactic plane. Several sizable samples of bright soft X-ray selected objects for follow-up ROSAT and ASTRO-D observations and statistical study are presented. The survey source list is expected to be available by late 1989. Both paper and remote access online data base versions are to be available. An identification program is considered.

  13. IPC出版IPC-7711/7721B版本

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    日前,IPC美国电子工业联接协会宣布出版IPC-7711/7721B版本,即电子组件的返工、修改和维修。此版本审核并更新了返工返修的每一个步骤(总共大约几百个),同时适用于无铅焊接和传统的锡铅合金焊接的组件。

  14. Enhanced IPC by activation of pertussis toxin-sensitive and -insensitive G protein-coupled purinoceptors.

    Science.gov (United States)

    Ninomiya, Hideki; Otani, Hajime; Lu, Kejie; Uchiyama, Takamichi; Kido, Masakuni; Imamura, Hiroji

    2002-05-01

    Extracellular ATP plays an important role in ischemic preconditioning (IPC) through the activation of P(2y) purinoceptors. This study examined whether ATP-stimulated P(2y) purinoceptors are coupled to pertussis toxin (PTX)-insensitive G protein and whether activation of this pathway enhances myocardial protection afforded by IPC. The rat was treated with PTX for 48 h, and the heart was then isolated and buffer perfused. The heart underwent IPC by three cycles of 5-min ischemia and 5-min reperfusion before 25 min of global ischemia. Isovolumic left ventricular function was measured, and functional recovery at 30 min after reperfusion was taken as an end point of myocardial protection. PTX pretreatment partially inhibited functional protection by IPC. Treatment with 100 microM 8-(p-sulfophenyl) theophylline (SPT) during IPC had no further effect on PTX-induced inhibition of functional protection by IPC, whereas suramin (300 microM) or reactive blue (RB) (10 microM) completely abolished myocardial protection in the preconditioned heart pretreated with PTX. Supplementation with adenosine (30 microM), ATP (30 microM), or UTP (50 microM) significantly enhanced IPC-induced functional protection, although preconditioning with these nucleotides without IPC had no protective effect. Adenosine-enhanced IPC was inhibited by pretreatment with PTX and SPT but not by suramin or RB, whereas ATP-enhanced IPC was inhibited by suramin or RB in combination with PTX pretreatment. On the other hand, UTP-enhanced IPC was not affected by PTX pretreatment but was inhibited by suramin or RB. Adenosine supplemented IPC without PTX pretreatment and ATP supplemented IPC with PTX pretreatment were not affected by nitric oxide synthase inhibitor N(omega)-nitro-L-arginine methyl ester (100 microM). Although the protein kinase C inhibitor Ro318425 (0.3 microM) or tyrosine kinase inhibitor genistein (50 microM) had no significant effect on the functional protection afforded by adenosine

  15. Process safety management: resources from the American Institute of Chemical Engineers for use by industrial hygienists.

    Science.gov (United States)

    Gideon, J A; Carmody, T W

    1992-06-01

    Industrial hygienists often work closely with engineers to control occupational safety and health hazards. This working relationship involves an educational process in which both engineers and industrial hygienists learn from one another. The Center for Chemical Process Safety (CCPS) of the American Institute of Chemical Engineers (AIChE) is expanding the opportunity for interdisciplinary cooperation and education by producing a series of guidelines publications on the technical and scientific issues critical to preventing and mitigating major releases of toxic materials. Examples of these guidelines include Hazard Evaluation Procedures; Technical Management of Chemical Process Safety; Chemical Process Quantitative Risk Analysis; and Safe Storage and Handling of Highly Toxic Hazardous Materials. Additional topics are addressed in the 8 guidelines in print and the 15 others in preparation. Several guidelines contain specific examples that illustrate how industrial hygienists, engineers, and other readers can use the guidelines to help address chemical process safety problems. Another CCPS activity involves an effort to include an awareness of health, safety, and loss prevention as an integral part of undergraduate chemical engineering education. For practicing engineers and industrial hygienists, a number of continuing education courses on topics such as process hazard analysis, process risk assessment, and process safety are offered by the AIChE. All of these resources are particularly timely in light of the Occupational Safety and Health Administration's recently enacted rule on Process Safety Management of Highly Hazardous Chemicals.

  16. Do provisions to advance chemical facility safety also advance chemical facility security? An analysis of possible synergies

    DEFF Research Database (Denmark)

    Hedlund, Frank Huess

    2012-01-01

    The European Commission has launched a study on the applicability of existing chemical industry safety provisions to enhancing security of chemical facilities covering the situation in 18 EU Member States. This paper reports some preliminary analytical findings regarding the extent to which exist...

  17. Evaluation model for safety capacity of chemical industrial park based on acceptable regional risk

    Institute of Scientific and Technical Information of China (English)

    Guohua Chen; Shukun Wang; Xiaoqun Tan

    2015-01-01

    The paper defines the Safety Capacity of Chemical Industrial Park (SCCIP) from the perspective of acceptable regional risk. For the purpose of exploring the evaluation model for the SCCIP, a method based on quantitative risk assessment was adopted for evaluating transport risk and to confirm reasonable safety transport capacity of chemical industrial park, and then by combining with the safety storage capacity, a SCCIP evaluation model was put forward. The SCCIP was decided by the smaller one between the largest safety storage capacity and the maximum safety transport capacity, or else, the regional risk of the park will exceed the acceptable level. The developed method was applied to a chemical industrial park in Guangdong province to obtain the maximum safety transport capacity and the SCCIP. The results can be realized in the regional risk control of the park effectively.

  18. Componentes Principales (C.P. de los sistemas de calculo del IPC base 92 y sistema IPC base 2001

    Directory of Open Access Journals (Sweden)

    Julio Pallas González

    2002-01-01

    Full Text Available Nueve años después de que se adoptara un cambio de base en el cálculo del IPC para el Estado Español, asistimos a un cambio de sistema en el cálculo del mismo, naciendo el sistema de índices de precios, base 2001. A lo largo de este trabajo y utilizando el programa estadístico SPSS, se tratará de realizar un análisis multivariante, sobre las distintas variables que componen el IPC base 92, del estado español, y las del índice, atendiendo al nuevo sistema base 2001, que entró en vigor en enero de 2002. De todas las técnicas multivariantes susceptibles de ser aplicadas en este trabajo, se utilizaran el análisis de componentes principales y el análisis factorial, con el fin de obtener factores no observables que permitan explicar, perdiendo la mínima información, las variables originales que representan.

  19. Interactive Chemical Safety for Sustainablity Toxicity Forecaster Dashboard

    Data.gov (United States)

    U.S. Environmental Protection Agency — EPA researchers have been using advances in computational toxicology to address lack of data on the thousands of chemicals. EPA released chemical data on 1,800...

  20. 77 FR 66638 - The Standard on Process Safety Management of Highly Hazardous Chemicals; Extension of the Office...

    Science.gov (United States)

    2012-11-06

    ... Occupational Safety and Health Administration The Standard on Process Safety Management of Highly Hazardous... the Standard on Process Safety Management of Highly Hazardous Chemicals. DATES: Comments must be... collection. Title: The Standard on Process Safety Management of Highly Hazardous Chemicals (29 CFR...

  1. Introducing Proper Chemical Hygiene and Safety in the General Chemistry Curriculum

    Science.gov (United States)

    Miller, Gordon J.; Heideman, Stephen A.; Greenbowe, Thomas J.

    2000-09-01

    Chemical safety is an important component of science education for everyone, not just for chemistry majors. Developing a responsible and knowledgeable attitude towards chemical safety best starts at the early stages of a student's career. In many colleges and universities, safety education in undergraduate chemistry has been relegated primarily to a few regulatory documents at the beginning of a laboratory course, or an occasional warning in the description of a specific experiment in a prelaboratory lecture. Safety issues are seldom raised in general chemistry or organic chemistry lecture-based chemistry courses. At Iowa State University we have begun to implement a program, Chemical Hygiene and Safety in the Laboratory, into the undergraduate chemistry curriculum. This program is designed to increase the awareness and knowledge of proper chemical hygiene and laboratory safety issues among all students taking general chemistry and organic chemistry courses. Laboratory protocol, use of safety equipment, familiarity with MSD sheets, basics of first aid, some specific terminology surrounding chemical hygiene, EPA and OSHA requirements, and the use of the World Wide Web to search and locate chemical safety information are topics that are applied throughout the chemistry curriculum. The novelty of this approach is to incorporate MSD sheets and safety information that can be located on the World Wide Web in a series of safety problems and assignments, all related to the chemistry experiments students are about to perform. The fundamental idea of our approach is not only to teach students what is required for appropriate safety measures, but also to involve them in the enforcement of basic prudent practices.

  2. An Investigative Study of Safety Management Practices in Chemical-Related Industries

    Science.gov (United States)

    Lewers, Sarah Grace

    Industrial chemicals are a major part of the United States economic growth and impact every product that we use in everyday life. Some of the major products produced by chemical-related industries are plastics, textiles, petroleum, paper and important metals. Governmental regulations like those created by the Occupational Safety and Health Organization (OSHA), Environmental Protection Agency (EPA) and the U.S. Chemical Safety and Hazard Investigation Board are vital to a chemical-related industries' safety management. Contributing to and helping to drive economic growth, the enforcement of proper safety practices is a necessity. This study was conducted to investigate and assess various safety management practices in selected chemical-related industries. The research design involved the use of a questionnaire/survey method in which a random sample of participants completed a questionnaire related to the variables of interest. Random sampling helps to ensure the generalizability of the survey results. The target population consisted of a subset of employees currently working for plants, businesses and organizations in chemical-related industries. To collect the data, surveys were given to employees in various positions at chemical-related industries such as basic chemicals, specialty chemicals, agricultural chemicals, pharmaceuticals and consumer products. A set of criteria was created to establish the qualification to be recognized as a chemical-related industry. The questionnaire/survey was reviewed by the Institutional Review Board at NC A&T State University to meet necessary regulation guidelines for research involving human subjects. The results showed that 60.22% or more than half of the respondents have worked with their company and organization for over thirty years providing the ability to see the progression of chemical-related industry safety management practices over time. Over eighty percent (80.66%) or 146 respondents agreed that their company or

  3. IPC two-color analysis of x ray galaxy clusters

    Science.gov (United States)

    White, Raymond E., III

    1990-01-01

    The mass distributions were determined of several clusters of galaxies by using X ray surface brightness data from the Einstein Observatory Imaging Proportional Counter (IPC). Determining cluster mass distributions is important for constraining the nature of the dark matter which dominates the mass of galaxies, galaxy clusters, and the Universe. Galaxy clusters are permeated with hot gas in hydrostatic equilibrium with the gravitational potentials of the clusters. Cluster mass distributions can be determined from x ray observations of cluster gas by using the equation of hydrostatic equilibrium and knowledge of the density and temperature structure of the gas. The x ray surface brightness at some distance from the cluster is the result of the volume x ray emissivity being integrated along the line of sight in the cluster.

  4. Using Behavioral Mapping to Examine the Validity of the IPIP-IPC

    Science.gov (United States)

    Markey, Patrick; Anderson, Juliene M.; Markey, Charlotte

    2013-01-01

    Behavioral mapping, a method designed to relate behaviors to circumplex models, was used to examine the predictive validity of the International Personality Item Pool-Interpersonal Circumplex (IPIP-IPC). In this study, 96 participants first completed the IPIP-IPC and then were videotaped in a social interaction with a confederate. At the…

  5. A Brief Assessment of the Interpersonal Circumplex: The IPIP-IPC

    Science.gov (United States)

    Markey, Patrick M.; Markey, Charlotte N.

    2009-01-01

    Three studies are presented that demonstrate the psychometric properties and initial validation of the International Personality Item Pool-Interpersonal Circumplex (IPIP-IPC). The IPIP-IPC is a brief 32-item assessment of the interpersonal cirucmplex designed to be used when time is limited or when participants have difficulty understanding the…

  6. Using Behavioral Mapping to Examine the Validity of the IPIP-IPC

    Science.gov (United States)

    Markey, Patrick; Anderson, Juliene M.; Markey, Charlotte

    2013-01-01

    Behavioral mapping, a method designed to relate behaviors to circumplex models, was used to examine the predictive validity of the International Personality Item Pool-Interpersonal Circumplex (IPIP-IPC). In this study, 96 participants first completed the IPIP-IPC and then were videotaped in a social interaction with a confederate. At the…

  7. Hazard Communication Standard for Chemical Labels and Safety Data Sheets In GHS Format

    Science.gov (United States)

    This fact sheet provides an overview of the required contents of Safety Data Sheets (SDSs) and chemical hazard labels, and includes tips on how these materials can be used to better protect health and the environment.

  8. Combined PDF and Rietveld studies of ADORable zeolites and the disordered intermediate IPC-1P.

    Science.gov (United States)

    Morris, Samuel A; Wheatley, Paul S; Položij, Miroslav; Nachtigall, Petr; Eliášová, Pavla; Čejka, Jiří; Lucas, Tim C; Hriljac, Joseph A; Pinar, Ana B; Morris, Russell E

    2016-09-28

    The disordered intermediate of the ADORable zeolite UTL has been structurally confirmed using the pair distribution function (PDF) technique. The intermediate, IPC-1P, is a disordered layered compound formed by the hydrolysis of UTL in 0.1 M hydrochloric acid solution. Its structure is unsolvable by traditional X-ray diffraction techniques. The PDF technique was first benchmarked against high-quality synchrotron Rietveld refinements of IPC-2 (OKO) and IPC-4 (PCR) - two end products of IPC-1P condensation that share very similar structural features. An IPC-1P starting model derived from density functional theory was used for the PDF refinement, which yielded a final fit of Rw = 18% and a geometrically reasonable structure. This confirms the layers do stay intact throughout the ADOR process and shows PDF is a viable technique for layered zeolite structure determination.

  9. CPCA与IPC合作完成IPC-T-50G中文版标准

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    CPCA标准化工作委员会于2004年10月成立术语工作组,开始IPC-T-50G《电子电路互连与封装术语和定义》中文版的翻译和审核。2006年,美国IPC-7-11CN工作组,也将进行IPC-T-50G中文版的翻译。2007年3N,CPCA与IPC商定,由CPCA术语工作组和IPC7-11CN联合共同承担IPC-T-50G中文版的翻译。

  10. 77 FR 71561 - Health and Safety Data Reporting; Addition of Certain Chemicals

    Science.gov (United States)

    2012-12-03

    ... this rule, health and safety studies regarding cadmium or cadmium compounds in articles must be... types of health, and/or environmental effects studies that need to be reported and the chemical... of Children From Environmental Health Risks and Safety Risks'' (62 FR 19885, April 23, 1997), because...

  11. Workshop on Indian Chemical Industry: perspectives on safety, cleaner production and environment production

    NARCIS (Netherlands)

    Ham, J.M.

    1996-01-01

    A Workshop on "Indian Chemical Industry: Perspectives on Safety, Cleaner Production and Environmental Protection" was held on 3, 4 and 5 January 1996, in Bombay, India. The main objective of the workshop, which was organised jointly by the Government of India, UNIDO/UNDP and the Indian Chemical Manu

  12. Occupational safety and health guidelines for chemical hazards. Supplement IV-OHG

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    This document is the fourth in a seris of supplements to the 1981 Publication NIOSH/OSHA Occupational Health Guidelines for Chemical Hazards. The 62 guidelines presented here in the fourth supplement include 11 revisions of previously issued guidelines and 51 new guidelines. The 62 occupational safety and health guidelines presented here are being published to disseminate technical information about chemical hazards to workers, employers, and occupational safety and health professionals. Each guideline includes (1) data on the chemical name and synonyms, cemnical and physical properties, exposure limits, and signs and symptoms of exposure, personal protective equipment, and control procedures.

  13. 78 FR 48029 - Improving Chemical Facility Safety and Security

    Science.gov (United States)

    2013-08-07

    ..., distributed, and used, are essential to today's economy. Past and recent tragedies have reminded us, however..., local, and tribal governments and private sector partners, where joint collaborative programs can be... information sharing and collaborative planning between chemical facility owners and operators, TEPCs, LEPCs...

  14. IPC-1/IPC-2在猫过敏患者减敏治疗中血清 IGE水平测定及过敏原因分析%Detection of the IgE in cat allergic patients and analysis of the allergic reaction cause during the hyposensitization with IPC-1/IPC-2

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    AIM:To analyse the cause of allergic reaction during thetreatment with synthetic peptide allergen IPC-1/IPC-2 (ALLERVAX CAT). METHODS: The measurement of allergen-specific IgE (as-IgE )level before and after the injection of IPC-1/IPC-2 and placebo in 27 cats allergic patients. Detection of the as-IgG, as-IgG4, as-IgE, T-IgE and histamine for one supernormal allergic person. RESULTS: No statistically significance were found in IgE in both IPC-1/IPC-2 and placebo groups. There were some obvious changes in the histamine, IgG and IgG4 levels, and not in IgE for this supernormal patient. CONCLUSION: IPC-1/IPC-2 has no effect on the IgE. Hypernormal reaction is not related to IgE during the hyposensitization. It may be related to the IgG, especially to the IgG4 which induce the histamine release that is non-IgE-dependent.%目的:分析高免疫活性的合成过敏原IPC-1/IPC-2(ALLERVAXCAT)在猫过敏患者减敏治疗中血清特异性IgE水平变化及过敏原因。方法:通过双盲,安慰剂对照实验检测27例猫过敏患者减敏治疗中血清IgE水平变化及其中1例超敏患者血特异性IgG、IgG4、特异性IgE、总IgE、组胺水平动态分析。结果:实验组与对照组IgE水平差异无显著性。动态检测血清特异性IgG,IgG4,组胺水平明显升高而血清总IgE和特异性IgE水平无变化。结论:IPC-1/IPC-2引起过敏反应与IgE无关,可能与非IgE依赖的组胺释放有关系。表明在部分人群中IgG、IgG4可能作为致敏抗体起类似IgE的作用。

  15. Do provisions to advance chemical facility safety also advance chemical facility security? An analysis of possible synergies

    DEFF Research Database (Denmark)

    Hedlund, Frank Huess

    2012-01-01

    endanger neighbouring populated areas. Second, facilities where high-risk chemicals are present could present opportunities for theft. The concern is that relatively small amounts of highly toxic chemicals could be taken to another location selected for higher impact. The Directive on European Critical......The European Commission has launched a study on the applicability of existing chemical industry safety provisions to enhancing security of chemical facilities covering the situation in 18 EU Member States. This paper reports some preliminary analytical findings regarding the extent to which...... exist at the mitigation level. At the strategic policy level, synergies are obvious. The security of chemical facilities is important. First, facilities with large inventories of toxic materials could be attractive targets for terrorists. The concern is sabotage causing an intentional release that could...

  16. Safety in the Chemical Laboratory: Tested Disposal Methods for Chemical Wastes from Academic Laboratories.

    Science.gov (United States)

    Armour, M. A.; And Others

    1985-01-01

    Describes procedures for disposing of dichromate cleaning solution, picric acid, organic azides, oxalic acid, chemical spills, and hydroperoxides in ethers and alkenes. These methods have been tested under laboratory conditions and are specific for individual chemicals rather than for groups of chemicals. (JN)

  17. IPC Position Paper Transitioning from MIL-P-50884C and MIL-PRF-31032 to IPC-6013 and Amendment 1

    CERN Document Server

    IPC - Association Connecting Electronics Industries. Northbrook, IL

    2000-01-01

    Developed and approved for distribution by the IPC Flexible Circuits Committee, this position paper serves as a guide for manufacturers and OEMs in transitioning from MIL-P-50884C and MIL-PRF-31032 to IPC-6013 and Amendment 1. The position paper offers a history of military specifications, from their overall development to the initiation of the Perry Initiative and Acquisition Reform. Also included in this document is a guide for implementing a Single Process Initiative (SPI), made available by the Department of the Navy (DoN)

  18. Accelerated wound healing with combined NPWT and IPC: a case series.

    Science.gov (United States)

    Arvesen, Kristian; Nielsen, Camilla Bak; Fogh, Karsten

    2017-03-01

    Negative pressure wound therapy (NPWT) and intermittent pneumatic compression (IPC) have traditionally been used in patients with chronic complicated non-healing wounds. The aim of this study (retrospective case series) was to describe the use of NPWT in combination with IPC in patients with a relatively short history (2-6 months) of ulcers. All wounds showed improved healing during the treatment period with marked or moderate reduction in ulcer size, and granulation tissue formation was markedly stimulated. Oedema was markedly reduced due to IPC. Treatment was generally well tolerated. The results of this study indicate that combined NPWT and IPC can accelerate wound healing and reduce oedema, thus shortening the treatment period. Therefore, patients may have a shorter healing period and may avoid entering a chronic wound phase. However, controlled studies of longer duration are needed in order to show the long-term effect of a more accelerated treatment course.

  19. Comparative lower limb hemodynamics using neuromuscular electrical stimulation (NMES) versus intermittent pneumatic compression (IPC).

    Science.gov (United States)

    Broderick, Barry J; O'Connell, Sandra; Moloney, Shelly; O'Halloran, Kevin; Sheehan, James; Quondamatteo, Fabio; Quinlan, Leo R; OLaighin, Gearoid

    2014-09-01

    Deep Vein Thrombosis (DVT) is a life threatening condition and a serious concern among hospitalised patients, with death occurring in approximately 6% of cases. Intermittent pneumatic compression (IPC) is commonly used for DVT prevention, however suffers from low compliance and issues of usability and portability. Neuromuscular electrical stimulation (NMES) has been shown to improve lower limb hemodynamics but direct comparison with IPC in terms of hemodynamics is rare but very important to determine the potential effectiveness of NMES in DVT prevention.Lower limb IPC was compared to calf NMES, in 30 healthy volunteers (18-23 years). Each intervention was carried out on each leg, on the popliteal vein measured using Doppler ultrasound. All interventions produced significantly greater haemodynamic responses compared to baseline. Calf-IPC and NMES produced significant increases in venous blood velocity (cm/s) and volume of blood ejected per cycle (1 cycle of NMES expels 23.22 ml compared to the baseline ejected volume of 2.52 ml, measured over 1 s (p IPC (x3 greater than foot-IPC and x1.7 greater than calf-IPC) more effectively emptying the veins and soleal sinuses. This is an important finding as DVT occurs predominantly in the soleal sinuses. NMES is silent and portable and thus does not suffer many of the issues associated with IPC. This work supports the potential widespread application of NMES in hospital and home settings where the risk of DVT formation is high.

  20. Application of gene expression data to safety evaluation of chemicals

    Institute of Scientific and Technical Information of China (English)

    ManaS

    2002-01-01

    Novel cyclopedic analytical systems of DNA microassay and GeneChip enable us to analyze several thousands of genes at a time.We performed GeneChip analysis on livers from rats administered various chemicals,namely,phenobarbital,clofibrate,3-methylocolanthrene,dexamethasone,butylated hydroxyanisole,acetaminophen and cycloheximide,all of which are known to induce hypertrophy or cell death of hepatocytes.The results indicated a number of up-regulated and down-regulated genes related to each treatment.Although the obtained data is quite useful,interpretation and statistical analysis of the data should be done taking into consideration the time point of sampling and several other factors,in particular,phenotype.On the other hand,we can not disregard the possibility that gene expression change which is not related to the toxic phenotype at a glance could play a key role in inducing a novel mechanism of toxicity,and this is one useful aspect of cyclopedic analysis of gene expression profiles.

  1. The Safety "Use Case": Co-Developing Chemical Information Management and Laboratory Safety Skills

    Science.gov (United States)

    Stuart, Ralph B.; McEwen, Leah R.

    2016-01-01

    The 2015 edition of the American Chemical Society's "Guidelines and Evaluation Procedures for Bachelor's Degree Programs" identifies six skill sets that undergraduate chemistry programs should instill in their students. In our roles as support staff for chemistry departments at two different institutions (one a Primarily Undergraduate…

  2. Task Group report to the Assistant Secretary for Environment, Safety and Health on oversight of chemical safety at the Department of Energy. Volume 2, Appendices

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-01

    This report presents the results of a preliminary review of chemical safety within the Department of Energy (DOE). The review was conducted by Chemical Safety Oversight Review (CSOR) Teams composed of Office of Environment, Safety and Health (EH) staff members and contractors. The primary objective of the CSOR was to assess, the safety status of DOE chemical operations and identify any significant deficiencies associated with such operations. Significant was defined as any situation posing unacceptable risk, that is, imminent danger or threat to workers, co-located workers, the general public, or the environment, that requires prompt action by EH or the line organizations. A secondary objective of the CSOR was to gather and analyze technical and programmatic information related to chemical safety to be used in conjunction with the longer-range EH Workplace Chemical Accident Risk Review (WCARR) Program. The WCARR Program is part of the ongoing EH oversight of nonnuclear safety at all DOE facilities. `` The program objective is to analyze DOE and industry chemical safety programs and performance and determine the need for additional or improved safety guidance for DOE. During the period June 6, 1992, through July 31, 1992, EH conducted CSORs at five DOE sites. The sites visited were Los Alamos National Laboratory (LANL), Savannah River Site (SRS), the Y-12 Plant (Y-12), Oak Ridge National Laboratory (ORNL), and Lawrence Livermore National Laboratory (LLNL).

  3. Conservation of Life as a Unifying Theme for Process Safety in Chemical Engineering Education

    Science.gov (United States)

    Klein, James A.; Davis, Richard A.

    2011-01-01

    This paper explores the use of "conservation of life" as a concept and unifying theme for increasing awareness, application, and integration of process safety in chemical engineering education. Students need to think of conservation of mass, conservation of energy, and conservation of life as equally important in engineering design and analysis.…

  4. Conservation of Life as a Unifying Theme for Process Safety in Chemical Engineering Education

    Science.gov (United States)

    Klein, James A.; Davis, Richard A.

    2011-01-01

    This paper explores the use of "conservation of life" as a concept and unifying theme for increasing awareness, application, and integration of process safety in chemical engineering education. Students need to think of conservation of mass, conservation of energy, and conservation of life as equally important in engineering design and analysis.…

  5. Chemical Safety Alert: Safe Storage and Handling of Swimming Pool Chemicals

    Science.gov (United States)

    Hazards of pool water treatment and maintenance chemicals (e.g., chlorine), and the protective measures pool owners should take to prevent fires, toxic vapor releases, and injuries. Triggered by improper wetting, mixing, or self-reactivity over time.

  6. Establishment and characterization of a new cell line of canine inflammatory mammary cancer: IPC-366.

    Directory of Open Access Journals (Sweden)

    Sara Caceres

    Full Text Available Canine inflammatory mammary cancer (IMC shares epidemiologic, histopathological and clinical characteristics with the disease in humans and has been proposed as a natural model for human inflammatory breast cancer (IBC. The aim of this study was to characterize a new cell line from IMC (IPC-366 for the comparative study of both IMC and IBC. Tumors cells from a female dog with clinical IMC were collected. The cells were grown under adherent conditions. The growth, cytological, ultrastructural and immunohistochemical (IHC characteristics of IPC-366 were evaluated. Ten female Balb/SCID mice were inoculated with IPC-366 cells to assess their tumorigenicity and metastatic potential. Chromosome aberration test and Karyotype revealed the presence of structural aberration, numerical and neutral rearrangements, demonstrating a chromosomal instability. Microscopic examination of tumor revealed an epithelial morphology with marked anysocytosis. Cytological and histological examination of smears and ultrathin sections by electron microscopy revealed that IPC-366 is formed by highly malignant large round or polygonal cells characterized by marked atypia and prominent nucleoli and frequent multinucleated cells. Some cells had cytoplasmic empty spaces covered by cytoplasmic membrane resembling capillary endothelial cells, a phenomenon that has been related to s vasculogenic mimicry. IHC characterization of IPC-366 was basal-like: epithelial cells (AE1/AE3+, CK14+, vimentin+, actin-, p63-, ER-, PR-, HER-2, E-cadherin, overexpressed COX-2 and high Ki-67 proliferation index (87.15 %. At 2 weeks after inoculating the IPC-366 cells, a tumor mass was found in 100 % of mice. At 4 weeks metastases in lung and lymph nodes were found. Xenograph tumors maintained the original IHC characteristics of the female dog tumor. In summary, the cell line IPC-366 is a fast growing malignant triple negative cell line model of inflammatory mammary carcinoma that can be used for the

  7. Establishment and characterization of a new cell line of canine inflammatory mammary cancer: IPC-366.

    Science.gov (United States)

    Caceres, Sara; Peña, Laura; de Andres, Paloma J; Illera, Maria J; Lopez, Mirtha S; Woodward, Wendy A; Reuben, James M; Illera, Juan C

    2015-01-01

    Canine inflammatory mammary cancer (IMC) shares epidemiologic, histopathological and clinical characteristics with the disease in humans and has been proposed as a natural model for human inflammatory breast cancer (IBC). The aim of this study was to characterize a new cell line from IMC (IPC-366) for the comparative study of both IMC and IBC. Tumors cells from a female dog with clinical IMC were collected. The cells were grown under adherent conditions. The growth, cytological, ultrastructural and immunohistochemical (IHC) characteristics of IPC-366 were evaluated. Ten female Balb/SCID mice were inoculated with IPC-366 cells to assess their tumorigenicity and metastatic potential. Chromosome aberration test and Karyotype revealed the presence of structural aberration, numerical and neutral rearrangements, demonstrating a chromosomal instability. Microscopic examination of tumor revealed an epithelial morphology with marked anysocytosis. Cytological and histological examination of smears and ultrathin sections by electron microscopy revealed that IPC-366 is formed by highly malignant large round or polygonal cells characterized by marked atypia and prominent nucleoli and frequent multinucleated cells. Some cells had cytoplasmic empty spaces covered by cytoplasmic membrane resembling capillary endothelial cells, a phenomenon that has been related to s vasculogenic mimicry. IHC characterization of IPC-366 was basal-like: epithelial cells (AE1/AE3+, CK14+, vimentin+, actin-, p63-, ER-, PR-, HER-2, E-cadherin, overexpressed COX-2 and high Ki-67 proliferation index (87.15 %). At 2 weeks after inoculating the IPC-366 cells, a tumor mass was found in 100 % of mice. At 4 weeks metastases in lung and lymph nodes were found. Xenograph tumors maintained the original IHC characteristics of the female dog tumor. In summary, the cell line IPC-366 is a fast growing malignant triple negative cell line model of inflammatory mammary carcinoma that can be used for the comparative

  8. Materials Safety Data Sheets: the basis for control of toxic chemicals

    Energy Technology Data Exchange (ETDEWEB)

    Ketchen, E.E.; Porter, W.E.

    1979-09-01

    The Material Safety Data Sheets contained in this volume are the basis for the Toxic Chemical Control Program developed by the Industrial Hygiene Department, Health Division, ORNL. The three volumes are the update and expansion of ORNL/TM-5721 and ORNL/TM-5722 Material Safety Data Sheets: The Basis for Control of Toxic Chemicals, Volume I and Volume II. As such, they are a valuable adjunct to the data cards issued with specific chemicals. The chemicals are identified by name, stores catalog number where appropriate, and sequence numbers from the NIOSH Registry of Toxic Effects of Chemical Substances, 1977 Edition, if available. The data sheets were developed and compiled to aid in apprising the employees of hazards peculiar to the handling and/or use of specific toxic chemicals. Space limitation necessitate the use of descriptive medical terms and toxicological abbreviations. A glossary and an abbreviation list were developed to define some of those sometimes unfamiliar terms and abbreviations. The page numbers are keyed to the catalog number in the chemical stores at ORNL.

  9. Materials Safety Data Sheets: the basis for control of toxic chemicals

    Energy Technology Data Exchange (ETDEWEB)

    Ketchen, E.E.; Porter, W.E.

    1979-09-01

    The Material Safety Data Sheets contained in this volume are the basis for the Toxic Chemical Control Program developed by the Industrial Hygiene Department, Health Division, ORNL. The three volumes are the update and expansion of ORNL/TM-5721 and ORNL/TM-5722 Material Safety Data Sheets: The Basis for Control of Toxic Chemicals, Volume I and Volume II. As such, they are a valuable adjunct to the data cards issued with specific chemicals. The chemicals are identified by name, stores catalog number where appropriate, and sequence numbers from the NIOSH Registry of Toxic Effects of Chemical Substances, 1977 Edition, if available. The data sheets were developed and compiled to aid in apprising the employees of hazards peculiar to the handling and/or use of specific toxic chemicals. Space limitation necessitate the use of descriptive medical terms and toxicological abbreviations. A glossary and an abbreviation list were developed to define some of those sometimes unfamiliar terms and abbreviations. The page numbers are keyed to the catalog number in the chemical stores at ORNL.

  10. A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals

    DEFF Research Database (Denmark)

    Vandenberg, Laura N.; Agerstrand, Marlene; Beronius, Anna

    2016-01-01

    .Conclusions: When using the SYRINA framework, the overall objective is to provide the evidence base needed to support decision making, including any action to avoid/minimise potential adverse effects of exposures. This framework allows for the evaluation and synthesis of evidence from multiple evidence streams...... on Chemical Safety (IPCS) and World Health Organization (WHO) definition of an EDC, which requires appraisal of evidence regarding 1) association between exposure and an adverse effect, 2) association between exposure and endocrine disrupting activity, and 3) a plausible link between the adverse effect...... and evaluate each stream of evidence; 6) Integrate evidence across all streams; 7) Draw conclusions, make recommendations, and evaluate uncertainties. The proposed method is tailored to the IPCS/WHO definition of an EDC but offers flexibility for use in the context of other definitions of EDCs...

  11. A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals

    DEFF Research Database (Denmark)

    Vandenberg, Laura N.; Agerstrand, Marlene; Beronius, Anna

    2016-01-01

    of evidence linking EDC exposures to adverse health or environmental outcomes. Systematic review methodologies are ideal for addressing this issue as they provide transparent and consistent approaches to study selection and evaluation. Objective methods are needed for integrating the multiple streams...... on Chemical Safety (IPCS) and World Health Organization (WHO) definition of an EDC, which requires appraisal of evidence regarding 1) association between exposure and an adverse effect, 2) association between exposure and endocrine disrupting activity, and 3) a plausible link between the adverse effect...... and evaluate each stream of evidence; 6) Integrate evidence across all streams; 7) Draw conclusions, make recommendations, and evaluate uncertainties. The proposed method is tailored to the IPCS/WHO definition of an EDC but offers flexibility for use in the context of other definitions of EDCs...

  12. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function.

    Science.gov (United States)

    Krug, Anne; French, Anthony R; Barchet, Winfried; Fischer, Jens A A; Dzionek, Andrzej; Pingel, Jeanette T; Orihuela, Michael M; Akira, Shizuo; Yokoyama, Wayne M; Colonna, Marco

    2004-07-01

    Natural interferon-producing cells (IPC) respond to viruses by secreting type I interferon (IFN) and interleukin-12 (IL-12). Toll-like receptor (TLR) 9 mediates IPC recognition of some of these viruses in vitro. However, whether TLR9-induced activation of IPC is necessary for an effective antiviral response in vivo is not clear. Here, we demonstrate that IPC and dendritic cells (DC) recognize murine cytomegalovirus (MCMV) through TLR9. TLR9-mediated cytokine secretion promotes viral clearance by NK cells that express the MCMV-specific receptor Ly49H. Although depletion of IPC leads to a drastic reduction of the IFN-alpha response, this allows other cell types to secrete IL-12, ensuring normal IFN-gamma and NK cell responses to MCMV. We conclude that the TLR9/MyD88 pathway mediates antiviral cytokine responses by IPC, DC, and possibly other cell types, which are coordinated to promote effective NK cell function and MCMV clearance.

  13. IPC/椰壳纤维与IPC/碳酸钙复合材料的研究%Study on IPC/Coir ifber and IPC/CaCO3 Composites

    Institute of Scientific and Technical Information of China (English)

    李丽平; 谭洪生; 刘永健; 刘雪静; 谭哲兴

    2014-01-01

    以抗冲共聚聚丙烯(IPC)为基体,对IPC/椰壳纤维与IPC/碳酸钙(CaCO3)复合材料的力学性能进行对比研究,并采用扫描电子显微镜(SEM)观察了它们的断面形貌,分析了椰壳纤维与CaCO3在IPC中的分散、粘结效果。结果表明,IPC/椰壳纤维复合材料在力学性能方面比IPC/CaCO3复合材料具有明显的优势,且随着填料含量的增加,优势越来越明显。SEM结果表明,椰壳纤维与IPC的界面粘结性良好,而CaCO3与IPC的界面粘结性很差,这是IPC/椰壳纤维与IPC/CaCO3复合材料力学性能有较大差异的一个重要原因。%Impact polypropylene copolymer(IPC) was used as matrix,and the mechanical properties of IPC/coir fiber and IPC/CaCO3 composites were compared. The fracture surface morphologies of the composites were observed by using scanning electron microscope(SEM) and the dispersion and bonding effect of CaCO3 and coir in IPC were analyzed. The results show that the mechanical properties of IPC/coir composites have obvious superiority than that of IPC/CaCO3 composites,and the superiority more obvious with the increase of the mass fraction of the fillers. SEM results show that the interfacial adhesion between coir fiber and IPC is better,and it is poor between the CaCO3 and IPC,which is an important reason of mechanical properties are quite different between them.

  14. Swelling and pillaring of the layered precursor IPC-1P: tiny details determine everything.

    Science.gov (United States)

    Shamzhy, Mariya; Mazur, Michal; Opanasenko, Maksym; Roth, Wieslaw J; Čejka, Jiří

    2014-07-21

    The influence of swelling (i.e. the size of tetraalkylammonium surfactant molecule, the presence of tetrapropylammonium hydroxide (TPAOH), pH) and pillaring (i.e. the ratio between the swollen precursor IPC-1P and tetraethyl orthosilicate) conditions on the structure and textural properties of the resulting materials was studied in detail for IPC-1P, which is the layered precursor of zeolite PCR. The swelling of IPC-1P proceeds efficiently under basic conditions both in mixed C(n)H(2n+1)N(CH3)3Cl/TPAOH systems and in C(n)H(2n+1)N(CH3)3OH (n = 8, 10, 12, 14, 16, 18) solutions at pH = 13-14. The intercalation of C(n)H(2n+1)N(+)(CH3)3 in IPC-1P resulted in the formation of expanded materials with interlayer distances growing with increasing length of the alkyl chain in C(n)H(2n+1)N(CH3)3(+): 1.59-1.86 (n = 8) IPC-2 zeolite was formed during calcination of IPC-1P samples swollen in C(n)H(2n+1)N(CH3)3OH solution, while PCR zeolite can be obtained by calcination of IPC-1P treated with either C(n)H(2n+1)N(CH3)3Cl/TPAOH or C(n)H(2n+1)N(CH3)3Cl. The pillaring of IPC-1P samples swollen with C(n)H(2n+1)N(CH3)3OH provided mesoporous materials with narrow pore size distribution in the range 2.5-3.5 nm. Pillared materials derived from the samples swollen in the presence of TPAOH were characterized by a broader pore size distribution. The optimal TEOS/IPC-1PSW ratio being sufficient for the formation of well-ordered pillared derivatives characterized by improved textural properties (S(BET) = 878 m(2) g(-1), V(total) = 0.599 cm(3) g(-1)) was found to be 1 : 1.5.

  15. The Experience-Based Safety Training System Using Vr Technology for Chemical Plant

    Directory of Open Access Journals (Sweden)

    Atsuko Nakai

    2014-11-01

    Full Text Available In chemical plants, safety measures are needed in order to minimize the impact of severe accidents and natural disasters. At the same time, carrying out the education and training to workers the corresponding operation in non-stationary situation is essential. However, reproducing the non-stationary conditions to actual equipment or mock-up cannot be performed because it is dangerous. By using the virtual reality (VR technology, we can build up a virtual chemical plant with lower cost compared to real plant. The operator can experience the fire and explosion accidents in the virtual space. Therefore, in this paper, we propose an experienced-based safety training system for implementing the education and training by using the non-stationary situation in the computer. This proposed system is linked with the dynamic plant simulator. A trainee can learn the correct operation through the simulated experience to prevent an accident. The safety awareness of workers will improve by experiential learning. The proposed system is useful for safety education in chemical plant.

  16. [Effectiveness of intermittent pneumatic compression (IPC) on thrombosis prophylaxis: a systematic literature review].

    Science.gov (United States)

    Rohrer, Ottilia; Eicher, Manuela

    2006-06-01

    Despite changes in patient demographics and short-ened length of hospital stay deep vein thrombosis (DVT) remains a major health care problem which may lead to a variety of other high risk complications. Current treatment guidelines focus on preventive measures. Beside drug therapy, physical measures executed by nursing professionals exist, the outcomes of which are discussed controversially. Based on 25 studies that were found in MEDLINE and the Cochrane library, this systematic literature review identifies the effectiveness of intermittent pneumatic compression (IPC) on thrombosis prophylaxis. In almost all medical settings IPC contributes to a significant reduction of the incidence of DVT. At the same time, IPC has minimal negative side effects and is also cost effective. Correct application of IPC and patient compliance are essential to achieve its effectiveness. An increased awareness within the healthcare team in identifying the risk for and implementing measures against DVT is needed. Guidelines need to be developed in order to improve the effectiveness of thrombosis prophylaxis with the implementation of IPC.

  17. Chemical food safety issues in the United States: past, present, and future.

    Science.gov (United States)

    Jackson, Lauren S

    2009-09-23

    Considerable advances have been made over the past century in the understanding of the chemical hazards in food and ways for assessing and managing these risks. At the turn of the 20th century, many Americans were exposed to foods adulterated with toxic compounds. In the 1920s the increasing use of insecticides led to concerns of chronic ingestion of heavy metals such as lead and arsenic from residues remaining on crops. By the 1930s, a variety of agrochemicals were commonly used, and food additives were becoming common in processed foods. During the 1940s and 1950s advances were made in toxicology, and more systematic approaches were adopted for evaluating the safety of chemical contaminants in food. Modern gas chromatography and liquid chromatography, both invented in the 1950s and 1960s, were responsible for progress in detecting, quantifying, and assessing the risk of food contaminants and adulterants. In recent decades, chemical food safety issues that have been the center of media attention include the presence of natural toxins, processing-produced toxins (e.g., acrylamide, heterocyclic aromatic amines, and furan), food allergens, heavy metals (e.g., lead, arsenic, mercury, cadmium), industrial chemicals (e.g., benzene, perchlorate), contaminants from packaging materials, and unconventional contaminants (melamine) in food and feed. Due to the global nature of the food supply and advances in analytical capabilities, chemical contaminants will continue to be an area of concern for regulatory agencies, the food industry, and consumers in the future.

  18. Testing Chemical Safety: What Is Needed to Ensure the Widespread Application of Non-animal Approaches?

    Science.gov (United States)

    Burden, Natalie; Sewell, Fiona; Chapman, Kathryn

    2015-05-01

    Scientists face growing pressure to move away from using traditional animal toxicity tests to determine whether manufactured chemicals are safe. Numerous ethical, scientific, business, and legislative incentives will help to drive this shift. However, a number of hurdles must be overcome in the coming years before non-animal methods are adopted into widespread practice, particularly from regulatory, scientific, and global perspectives. Several initiatives are nevertheless underway that promise to increase the confidence in newer alternative methods, which will support the move towards a future in which less data from animal tests is required in the assessment of chemical safety.

  19. Testing Chemical Safety: What Is Needed to Ensure the Widespread Application of Non-animal Approaches?

    Directory of Open Access Journals (Sweden)

    Natalie Burden

    2015-05-01

    Full Text Available Scientists face growing pressure to move away from using traditional animal toxicity tests to determine whether manufactured chemicals are safe. Numerous ethical, scientific, business, and legislative incentives will help to drive this shift. However, a number of hurdles must be overcome in the coming years before non-animal methods are adopted into widespread practice, particularly from regulatory, scientific, and global perspectives. Several initiatives are nevertheless underway that promise to increase the confidence in newer alternative methods, which will support the move towards a future in which less data from animal tests is required in the assessment of chemical safety.

  20. Safety Issues of HG and PB as IFE Target Materials: Radiological Versus Chemical Toxicity

    Energy Technology Data Exchange (ETDEWEB)

    Reyes, S; Latkowski, J F; Cadwallader, L C; Moir, R W; Rio, G. D; Sanz, J

    2002-11-11

    We have performed a safety assessment of mercury and lead as possible hohlraum materials for Inertial Fusion Energy (IFE) targets, including for the first time a comparative analysis of the radiological and toxicological consequences of an accidental release. In order to calculate accident doses to the public, we have distinguished between accidents at the target fabrication facility and accidents at other areas of the power plant. Regarding the chemical toxicity assessment, we have used the USDOE regulations to determine the maximum allowable release in order to protect the public from adverse health effects. Opposite to common belief, it has been found that the chemical safety requirements for these materials appear to be more stringent than the concentrations that would result in an acceptable radiological dose.

  1. Empalme de subclases del IPC de Chile Series mensuales 1989-2008

    OpenAIRE

    Michael Pedersen; Hernán Rubio; Carlos Saavedra

    2009-01-01

    En este trabajo se presenta el empalme de las series a nivel de subclases del Índice de Precios al Consumidor (IPC) de Chile, para el período que va desde abril-1989 hasta diciembre-2008. La metodología ocupada es la misma que utiliza el Instituto Nacional de Estadísticas (INE) para obtener series empalmadas del IPC total. Se describen las homologaciones entre los productos de las canastas con distintas bases y los supuestos utilizados para llevar a cabo este empalme. Como parte del ejercicio...

  2. Novel approaches to improving the chemical safety of the meat chain towards toxicants.

    Science.gov (United States)

    Engel, E; Ratel, J; Bouhlel, J; Planche, C; Meurillon, M

    2015-11-01

    In addition to microbiological issues, meat chemical safety is a growing concern for the public authorities, chain stakeholders and consumers. Meat may be contaminated by various chemical toxicants originating from the environment, treatments of agricultural production or food processing. Generally found at trace levels in meat, these toxicants may harm human health during chronic exposure. This paper overviews the key issues to be considered to ensure better control of their occurrence in meat and assessment of the related health risk. We first describe potential contaminants of meat products. Strategies to move towards a more efficient and systematic control of meat chemical safety are then presented in a second part, with a focus on emerging approaches based on toxicogenomics. The third part presents mitigation strategies to limit the impact of process-induced toxicants in meat. Finally, the last part introduces methodological advances to refine chemical risk assessment related to the occurrence of toxicants in meat by quantifying the influence of digestion on the fraction of food contaminants that may be assimilated by the human body.

  3. A performance evaluation of a new iron oxide-based porous ceramsite (IPC) in biological aerated filters.

    Science.gov (United States)

    Bao, Teng; Chen, Tianhu; Ezzatahmadi, Naeim; Rathnayake, Suramya I; Chen, Dong; Wille, Marie-Luise; Frost, Ray

    2017-04-01

    A novel medium containing iron oxide-based porous ceramsite (IPC) and commercial ceramsite (CC) was used in two laboratory-scale upflow biological aerated filters (BAFs) to treat city wastewater to compare their efficacy in wastewater treatment. The IPC BAF and CC BAF were operated in water at 20-26°C, an air/water (A/W) ratio of: 3:1 and hydraulic retention times (HRTs) of 7, 3.5, 1.75, and 0.5 h and the removal of ammonia nitrogen (NH3-N), total nitrogen (TN), total organic carbon (TOC), and phosphorus (P) were studied. Our results indicated that IPC BAF was superior to CC BAF in terms of TOC, TN, NH3-N, and P removal. IPC had higher total porosity and larger total surface area than CC. The interconnected porous structure of IPC was suitable to microbial growth, protozoan, and metazoan organisms were primarily found in the accumulated biofilm layer. Biomass, in the biofilm layer, was detected at three distinct distances (300, 900, and 1500 mm) from the bottom of the inlet filter, again indicating that the IPC was more suitable for biomass growth. The presence of biomass improves the simultaneous removal efficiency of nitrogen and phosphorus in the IPC BAF. Thus, our findings support IPC as a material for use in filter media in wastewater treatment BAFs.

  4. Ensuring Adequate Health and Safety Information for Decision Makers during Large-Scale Chemical Releases

    Science.gov (United States)

    Petropoulos, Z.; Clavin, C.; Zuckerman, B.

    2015-12-01

    The 2014 4-Methylcyclohexanemethanol (MCHM) spill in the Elk River of West Virginia highlighted existing gaps in emergency planning for, and response to, large-scale chemical releases in the United States. The Emergency Planning and Community Right-to-Know Act requires that facilities with hazardous substances provide Material Safety Data Sheets (MSDSs), which contain health and safety information on the hazardous substances. The MSDS produced by Eastman Chemical Company, the manufacturer of MCHM, listed "no data available" for various human toxicity subcategories, such as reproductive toxicity and carcinogenicity. As a result of incomplete toxicity data, the public and media received conflicting messages on the safety of the contaminated water from government officials, industry, and the public health community. Two days after the governor lifted the ban on water use, the health department partially retracted the ban by warning pregnant women to continue avoiding the contaminated water, which the Centers for Disease Control and Prevention deemed safe three weeks later. The response in West Virginia represents a failure in risk communication and calls to question if government officials have sufficient information to support evidence-based decisions during future incidents. Research capabilities, like the National Science Foundation RAPID funding, can provide a solution to some of the data gaps, such as information on environmental fate in the case of the MCHM spill. In order to inform policy discussions on this issue, a methodology for assessing the outcomes of RAPID and similar National Institutes of Health grants in the context of emergency response is employed to examine the efficacy of research-based capabilities in enhancing public health decision making capacity. The results of this assessment highlight potential roles rapid scientific research can fill in ensuring adequate health and safety data is readily available for decision makers during large

  5. High-resolution adsorption analysis of pillared zeolites IPC-3PI and MCM-36.

    Science.gov (United States)

    Zukal, Arnošt; Kubů, Martin

    2014-07-21

    The porous structure of pillared zeolites IPC-3PI and MCM-36 and their precursors IPC-3P and MCM-22P, respectively, has been investigated by means of a high-resolution adsorption analysis. The analysis was based on argon adsorption isotherms measured at 87 K from the relative pressure of 10(-6). The isotherms were processed by means of the t-plot method, which made it possible to distinguish adsorption in micropores from adsorption in mesopores. The pore size distribution was evaluated from argon isotherms using Non-Local Density Functional Theory. The obtained results have shown that the microporous structure of the MWW layers is preserved in both pillared zeolites. In contrast to precursors IPC-3P and MCM-22P, pillared samples are characterized by the formation of a porous structure belonging to the lower mesopore region. The distribution of mesopores in the zeolite IPC-3PI is broader and is shifted to larger widths in comparison with the zeolite MCM-36.

  6. Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription.

    Science.gov (United States)

    Huseby, S; Gausdal, G; Keen, T J; Kjærland, E; Krakstad, C; Myhren, L; Brønstad, K; Kunick, C; Schwede, F; Genieser, H-G; Kleppe, R; Døskeland, S O

    2011-12-08

    The IPC-81 cell line is derived from the transplantable BNML model of acute myelogenic leukemia (AML), known to be a reliable predictor of the clinical efficiency of antileukemic agents, like the first-line AML anthracycline drug daunorubicin (DNR). We show here that cAMP acted synergistically with DNR to induce IPC cell death. The DNR-induced death differed from that induced by cAMP by (1) not involving Bim induction, (2) being abrogated by GSK3β inhibitors, (3) by being promoted by the HSP90/p23 antagonist geldanamycin and truncated p23 and (4) by being insensitive to the CRE binding protein (CREB) antagonist ICER and to cyclin-dependent protein kinase (CDK) inhibitors. In contrast, the apoptosis induced by cAMP correlated tightly with Bim protein expression. It was abrogated by Bim (BCL2L11) downregulation, whether achieved by the CREB antagonist ICER, by CDK inhibitors, by Bim-directed RNAi, or by protein synthesis inhibitor. The forced expression of BimL killed IPC-81(WT) cells rapidly, Bcl2-overexpressing cells being partially resistant. The pivotal role of CREB and CDK activity for Bim transcription is unprecedented. It is also noteworthy that newly developed cAMP analogs specifically activating PKA isozyme I (PKA-I) were able to induce IPC cell apoptosis. Our findings support the notion that AML cells may possess targetable death pathways not exploited by common anti-cancer agents.

  7. CHEMICALS

    CERN Document Server

    Medical Service

    2002-01-01

    It is reminded that all persons who use chemicals must inform CERN's Chemistry Service (TIS-GS-GC) and the CERN Medical Service (TIS-ME). Information concerning their toxicity or other hazards as well as the necessary individual and collective protection measures will be provided by these two services. Users must be in possession of a material safety data sheet (MSDS) for each chemical used. These can be obtained by one of several means : the manufacturer of the chemical (legally obliged to supply an MSDS for each chemical delivered) ; CERN's Chemistry Service of the General Safety Group of TIS ; for chemicals and gases available in the CERN Stores the MSDS has been made available via EDH either in pdf format or else via a link to the supplier's web site. Training courses in chemical safety are available for registration via HR-TD. CERN Medical Service : TIS-ME :73186 or service.medical@cern.ch Chemistry Service : TIS-GS-GC : 78546

  8. EPA Proposes Revisions to its Risk Management Program to Improve Chemical Process Safety and Further Protect Communities and First Responders

    Science.gov (United States)

    WASHINGTON - The U.S. Environmental Protection Agency (EPA) is proposing to revise its Risk Management Program (RMP) regulations to improve chemical process safety, assist local emergency authorities in planning for and responding to accidents, and

  9. Notification: FY 2012 Management Challenges and Internal Control Weaknesses for the Chemical Safety and Hazard Investigation Board

    Science.gov (United States)

    February 1, 2012. The EPA Office of Inspector General is beginning work to update our list of areas we consider to be the key management challenges confronting the Chemical Safety and Hazard Investigation Board.

  10. The Efficacy of a Condensed "Seeking Safety" Intervention for Women in Residential Chemical Dependence Treatment at 30 Days Posttreatment

    Science.gov (United States)

    Cash Ghee, Anna; Bolling, Lanny C.; Johnson, Candace S.

    2009-01-01

    This study examined the efficacy of a condensed version of the "Seeking Safety" intervention in the reduction of trauma-related symptoms and improved drug abstinence rates among women in residential chemical dependence treatment. One hundred and four women were randomly assigned to treatment including a condensed (six session) "Seeking Safety"…

  11. Tools to prevent process safety events at university research facility - chemical risk assessment and experimental set-up risk assessment

    DEFF Research Database (Denmark)

    Jensen, Niels; Jørgensen, Sten Bay

    2014-01-01

    The article discusses the two forms developed to examine the hazards of the chemicals to be used in the experiments in the experimental setup in the Department of Chemical and Biochemical Engineering of the Technical University of Denmark. A system for the safety assessment of new experimental...

  12. IMPLEMENTATION OF A SAFETY PROGRAM FOR THE WORK ACCIDENTS’ CONTROL. A CASE STUDY IN THE CHEMICAL INDUSTRY

    Directory of Open Access Journals (Sweden)

    Edison Cesar de Faria Nogueira

    2015-03-01

    Full Text Available This article presents a case study related to the implementation of a Work Safety Program in a chemical industry, based on the Process Safety Program, PSP, of a huge energy company. The research was applied, exploratory, qualitative and with and data collection method through documentary and bibliographical research. There will be presented the main practices adopted in order to make the Safety Program a reality inside a chemical industry, its results and contributions for its better development. This paper proposes the implementation of a Safety Program must be preceded by a diagnosis of occupational safety and health management system and with constant critical analysis in order to make the necessary adjustments.

  13. Tolerance and safety of superficial chemical peeling with salicylic acid in various facial dermatoses

    Directory of Open Access Journals (Sweden)

    Iqbal Zafar

    2005-03-01

    Full Text Available BACKGROUND: Chemical peeling is a skin-wounding procedure that may have some potentially undesirable side-effects. AIMS: The present study is directed towards safety concerns associated with superficial chemical peeling with salicylic acid in various facial dermatoses. METHODS: The study was a non-comparative and a prospective one. Two hundred and sixty-eight patients of either sex, aged between 10 to 60 years, undergoing superficial chemical peeling for various facial dermatoses (melasma, acne vulgaris, freckles, post-inflammatory scars/pigmentation, actinic keratoses, plane facial warts, etc. were included in the study. Eight weekly peeling sessions were carried out in each patient. Tolerance to the procedure and any undesirable effects noted during these sessions were recorded. RESULTS: Almost all the patients tolerated the procedure well. Mild discomfort, burning, irritation and erythema were quite common but the incidence of major side-effects was very low and these too, were easily manageable. There was no significant difference in the incidence of side-effects between facial dermatoses (melasma, acne and other pigmentary disorders. CONCLUSION: Chemical peeling with salicylic acid is a well tolerated and safe treatment modality in many superficial facial dermatoses.

  14. Chemical management and control strategies: experiences from the GTZ pilot project on chemical safety in Indonesian small and medium-sized enterprises.

    Science.gov (United States)

    Tischer, M; Scholaen, S

    2003-10-01

    In 1998 the Deutsche Gesellschaft für Technische Zusammenarbeit (GTZ) launched the Convention Project on Chemical Safety in developing countries. The project aims to support developing countries in the implementation of the Rotterdam and Stockholm Conventions, create human resources and institutional capacities and to demonstrate via pilot measures how chemical safety in the partner countries can be improved and sustainably implemented in line with international standards. With this objective the development of a Chemical Management Guide (CM Guide) for small and medium-sized enterprises in developing countries has been initiated. The guide describes a step-by-step approach which is based on identifying 'hot-spots' as a first step, and making a chemical inventory as a second step. The third step is the continuous improvement of chemical management. In total, there are six tools that aim to support the chemical management process: basic concepts for risk assessment; description of control approaches; using material safety data sheets (MSDSs); risk phrases for hazardous substances; safety phrases for hazardous substances; symbols used for labelling hazardous substances. In the course of the test-implementation of the CM Guide in Indonesia, it was found that MSDSs were not available in most of the smaller companies. In contrast, medium-sized and larger companies do have more MSDSs available. It was also found that the way to engage the minds of company owners and managers is with economic arguments related to the loss, waste and expiry of materials, and quality standards expected from importing countries.

  15. Safety evaluation report related to the renewal of the facility license for the research reactor at the Dow Chemical Company

    Energy Technology Data Exchange (ETDEWEB)

    1989-04-01

    This safety evaluation report for the application filed by the Dow Chemical Company for renewal of facility Operating License R-108 to continue to operate its research reactor at an increased operating power level has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located on the grounds of the Michigan Division of the Dow Chemical Company in Midland, Michigan. The staff concludes that the Dow Chemical Company can continue to operate its reactor without endangering the health and safety of the public.

  16. SAFETY

    CERN Document Server

    Niels Dupont

    2013-01-01

    CERN Safety rules and Radiation Protection at CMS The CERN Safety rules are defined by the Occupational Health & Safety and Environmental Protection Unit (HSE Unit), CERN’s institutional authority and central Safety organ attached to the Director General. In particular the Radiation Protection group (DGS-RP1) ensures that personnel on the CERN sites and the public are protected from potentially harmful effects of ionising radiation linked to CERN activities. The RP Group fulfils its mandate in collaboration with the CERN departments owning or operating sources of ionising radiation and having the responsibility for Radiation Safety of these sources. The specific responsibilities concerning "Radiation Safety" and "Radiation Protection" are delegated as follows: Radiation Safety is the responsibility of every CERN Department owning radiation sources or using radiation sources put at its disposition. These Departments are in charge of implementing the requi...

  17. An audit of intermittent pneumatic compression (IPC) in the prophylaxis of asymptomatic deep vein thrombosis (DVT).

    Science.gov (United States)

    Illingworth, Clare; Timmons, Stephen

    2007-11-01

    This paper reports a prospective audit, against an existing baseline standard, for intermittent pneumatic compression (IPC) in the prophylaxis of asymptomatic deep vein thrombosis (DVT). This was done via a structured questionnaire, using the methodology of total population sampling, encapsulating all theatre staff within one NHS trust. With regards to the standard, performance is good, as IPC is DVT prophylaxis of choice in the perioperative area and is used frequently on most patients. The findings of the audit do, however, highlight the need for appropriate local DVT risk assessment guidelines, essential to ensure that prophylaxis is administered to the correct at risk groups, as prevention may be unjustified in low risk groups and possibly inappropriate for the same regimen to be used for all patients.

  18. Nano-Scale Interpenetrating Phase Composites (IPC S) for Industrial and Vehicle Applications

    Energy Technology Data Exchange (ETDEWEB)

    Hemrick, James Gordon [ORNL; Hu, Michael Z. [ORNL

    2010-06-01

    A one-year project was completed at Oak Ridge National Laboratory (ORNL) to explore the technical and economic feasibility of producing nano-scale Interpenetrating Phase Composite (IPC) components of a usable size for actual testing/implementation in a real applications such as high wear/corrosion resistant refractory shapes for industrial applications, lightweight vehicle braking system components, or lower cost/higher performance military body and vehicle armor. Nano-scale IPC s with improved mechanical, electrical, and thermal properties have previously been demonstrated at the lab scale, but have been limited in size. The work performed under this project was focused on investigating the ability to take the current traditional lab scale processes to a manufacturing scale through scaling of these processes or through the utilization of an alternative high-temperature process.

  19. Design and implementation of an IPC-based control system for mobile robots

    Institute of Scientific and Technical Information of China (English)

    Jia Jianqiang; Chen Weidong; Xi Yugeng

    2005-01-01

    This paper introduces an autonomous mobile robot system applicable under dynamicenvironment. Every robot contains a multi-sensor system, a differential-drivevehicle and a wireless LAN. A real-time on-board control system makes decision autonomously according to the perception from the multi-sensor system. Under the Windows operation system (OS), inter-process communication (IPC) mechanism of Linux OS is introduced into control system design. A distributed software architecture based on IPC, which can be used for multiple mobile robots system, is proposed. The architecture can make the system more flexible and scalable. The expansion of robot's function and cooperation between robots can be easily realized. The experiments and robot soccer game show the validity of the architecture.

  20. A home-made system for IPCE measurement of standard and dye-sensitized solar cells.

    Science.gov (United States)

    Palma, Giuseppina; Cozzarini, Luca; Capria, Ennio; Fraleoni-Morgera, Alessandro

    2015-01-01

    A home-made system for incident photon-to-electron conversion efficiency (IPCE) characterization, based on a double-beam UV-Vis spectrophotometer, has been set up. In addition to its low cost (compared to the commercially available apparatuses), the double-beam configuration gives the advantage to measure, autonomously and with no need for supplementary equipment, the lamp power in real time, compensating possible variations of the spectral emission intensity and quality, thus reducing measurement times. To manage the optical and electronic components of the system, a custom software has been developed. Validations carried out on a common silicon-based photodiode and on a dye-sensitized solar cell confirm the possibility to adopt this system for determining the IPCE of solar cells, including dye-sensitized ones.

  1. Establishment and Characterization of a New Cell Line of Canine Inflammatory Mammary Cancer: IPC-366

    OpenAIRE

    Sara Caceres; Laura Peña; de Andres, Paloma J.; Maria J Illera; Mirtha S Lopez; Woodward, Wendy A; Reuben, James M.; Illera, Juan C.

    2015-01-01

    Canine inflammatory mammary cancer (IMC) shares epidemiologic, histopathological and clinical characteristics with the disease in humans and has been proposed as a natural model for human inflammatory breast cancer (IBC). The aim of this study was to characterize a new cell line from IMC (IPC-366) for the comparative study of both IMC and IBC. Tumors cells from a female dog with clinical IMC were collected. The cells were grown under adherent conditions. The growth, cytological, ultrastructur...

  2. Canine cell line, IPC-366, as a good model for the study of inflammatory breast cancer.

    Science.gov (United States)

    Caceres, S; Peña, L; Lacerda, L; Illera, M J; de Andres, P J; Larson, R A; Gao, H; Debeb, B G; Woodward, W A; Reuben, J M; Illera, J C

    2017-09-01

    Inflammatory breast cancer (IBC) is an aggressive type of cancer with poor survival in women. Inflammatory mammary cancer (IMC) in dogs is very similar to human IBC and it has been proposed as a good surrogate model for study the human disease. The aim was to determine if IPC-366 shared characteristics with the IBC cell line SUM149. The comparison was conducted in terms of ability to grow (adherent and nonadherent conditions), stem cell markers expression using flow cytometry, protein production using western blot and tumorigenic capacity. Our results revealed that both are capable of forming long-term mammospheres with a grape-like morphology. Adherent and nonadherent cultures exhibited fast growth in vivo. Stem cell markers expressions showed that IPC-366 and SUM149 in adherent and nonadherent conditions has mesenchymal-like characteristics, E-cadherin and N-cadherin, was higher in adherent than in nonadherent cultures. Therefore, this study determines that both cell lines are similar and IPC-366 is a good model for the human and canine disease. © 2016 John Wiley & Sons Ltd.

  3. Iterative tuning of feedforward IPC for two-bladed wind turbines

    Science.gov (United States)

    Mulders, SP; van Solingen, E.; van Wingerden, JW; Beerens, J.

    2016-09-01

    At present, the cost of offshore wind energy does not meet the level of onshore wind and fossil-based energy sources. One way to extend the turbine lifetime, and thus reduce cost, is by reduction of the fatigue loads of blades and other turbine parts using Individual Pitch Control (IPC). This type of control, which is generally implemented by feedback control using the MultiBlade Coordinate transformation on blade load measurement signals, is capable of mitigating the most dominant periodic loads. The main goal of this article is to develop a self-optimizing feedforward IPC strategy for a two-bladed wind turbine to reduce actuator duty cycle and reduce the dependency on blade load measurement signals. The approach uses blade load measurement data only initially for tuning of the feedforward controller, which is scheduled on the rotor azimuth angle and wind speed. The feedforward strategy will be compared to the feedback implementation in terms of load alleviation capabilities and actuator duty cycle. Results show that the implementation is capable of learning the optimal feedforward IPC controller in constant and turbulent wind conditions, to alleviate the pitch actuator duty cycle, and to considerably reduce harmonic fatigue loads without the need for blade load measurement signals after tuning.

  4. IPC Works Asia 2009技术研讨会10月深圳开幕

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    IPC Works Asia 2009即将于2009年10月26日在深圳拉开帷幕。今年的活动包括:主题技术研讨会、IPCTG Asia技术组会议、IPC会员免费CIS级别培训、IPC 175X材料声明系列标准精解讲座、IPC 7351/7251讲座、高效实用的高速印制电路设计方法讲座、IPC 020/033讲座等精彩的技术内容。

  5. Safety

    CERN Multimedia

    2003-01-01

    Please note that the safety codes A9, A10 AND A11 (ex annexes of SAPOCO/42) entitled respectively "Safety responsibilities in the divisions" "The safety policy committee (SAPOCO) and safety officers' committees" and "Administrative procedure following a serious accident or incident" are available on the web at the following URLs: Code A9: http://edms.cern.ch/document/337016/LAST_RELEASED Code A10: http://edms.cern.ch/document/337019/LAST_RELEASED Code A11: http://edms.cern.ch/document/337026/LAST_RELEASED Paper copies can also be obtained from the TIS divisional secretariat, e-mail: tis.secretariat@cern.ch. TIS Secretariat

  6. Stereoselective synthesis of 1,3-anti diols by an Ipc-mediated domino aldol-coupling/reduction sequence.

    Science.gov (United States)

    Dieckmann, Michael; Menche, Dirk

    2013-01-04

    A novel domino process for 1,3-anti diol synthesis by the union of a methyl ketone with an aldehyde is described. The operationally simple procedure is based on an Ipc-boron-aldol coupling and subsequent Ipc-mediated reduction of the intermediate β-hydroxy-ketone. The sequence proceeds with excellent anti-selectivities and enables the rapid construction of complex polyketide fragments.

  7. ‘Geo’chemical research: A key building block for nuclear waste disposal safety cases

    Science.gov (United States)

    Altmann, Scott

    2008-12-01

    Disposal of high level radioactive waste in deep underground repositories has been chosen as solution by several countries. Because of the special status this type waste has in the public mind, national implementation programs typically mobilize massive R&D efforts, last decades and are subject to extremely detailed and critical social-political scrutiny. The culminating argument of each program is a 'Safety Case' for a specific disposal concept containing, among other elements, the results of performance assessment simulations whose object is to model the release of radionuclides to the biosphere. Public and political confidence in performance assessment results (which generally show that radionuclide release will always be at acceptable levels) is based on their confidence in the quality of the scientific understanding in the processes included in the performance assessment model, in particular those governing radionuclide speciation and mass transport in the geological host formation. Geochemistry constitutes a core area of research in this regard. Clay-mineral rich formations are the subjects of advanced radwaste programs in several countries (France, Belgium, Switzerland…), principally because of their very low permeabilities and demonstrated capacities to retard by sorption most radionuclides. Among the key processes which must be represented in performance assessment models are (i) radioelement speciation (redox state, speciation, reactions determining radionuclide solid-solution partitioning) and (ii) diffusion-driven transport. The safety case must therefore demonstrate a detailed understanding of the physical-chemical phenomena governing the effects of these two aspects, for each radionuclide, within the geological barrier system. A wide range of coordinated (and internationally collaborated) research has been, and is being, carried out in order to gain the detailed scientific understanding needed for constructing those parts of the Safety Case

  8. 'Geo'chemical research: a key building block for nuclear waste disposal safety cases.

    Science.gov (United States)

    Altmann, Scott

    2008-12-12

    Disposal of high level radioactive waste in deep underground repositories has been chosen as solution by several countries. Because of the special status this type waste has in the public mind, national implementation programs typically mobilize massive R&D efforts, last decades and are subject to extremely detailed and critical social-political scrutiny. The culminating argument of each program is a 'Safety Case' for a specific disposal concept containing, among other elements, the results of performance assessment simulations whose object is to model the release of radionuclides to the biosphere. Public and political confidence in performance assessment results (which generally show that radionuclide release will always be at acceptable levels) is based on their confidence in the quality of the scientific understanding in the processes included in the performance assessment model, in particular those governing radionuclide speciation and mass transport in the geological host formation. Geochemistry constitutes a core area of research in this regard. Clay-mineral rich formations are the subjects of advanced radwaste programs in several countries (France, Belgium, Switzerland...), principally because of their very low permeabilities and demonstrated capacities to retard by sorption most radionuclides. Among the key processes which must be represented in performance assessment models are (i) radioelement speciation (redox state, speciation, reactions determining radionuclide solid-solution partitioning) and (ii) diffusion-driven transport. The safety case must therefore demonstrate a detailed understanding of the physical-chemical phenomena governing the effects of these two aspects, for each radionuclide, within the geological barrier system. A wide range of coordinated (and internationally collaborated) research has been, and is being, carried out in order to gain the detailed scientific understanding needed for constructing those parts of the Safety Case

  9. Regulation and safety implementation of nanotechnology for chemical enterprises in the Central Europe Space

    Science.gov (United States)

    Falk, A.; Hartl, S.; Sinner, F.

    2013-04-01

    As result of the gradually increasing nanotechnology sector there is the necessity of a contemporary analysis of the present regulations used for nanomaterials, to outline the current situation of the nanotechnology sector, to promote international cooperation and research's coordination to overcome disciplinary boundaries, to fill the gap between more and less experienced regions and to turn investments in R&D in industrial innovations. The general objective of the Central Europe project NANOFORCE, which is developed by national and regional chemistry associations and R&D Centres of the Central Europe area, is to foster the innovative nanotechnology-sector networks across Central Europe regions by bringing together public and private organizations to carry out collaborative and interdisciplinary researches on nanomaterials (in the frame of REACH Regulation) and to turn the most promising laboratory results into innovative industrial applications. To build up a legal advisory board for chemical enterprises starting in nanotechnology, a state of the art report on existing safety procedures and nanotech related regulations was produced to give an overview on currently available regulations used by chemical industries and manufacturing companies within the European region to secure their products. The main emphasis was placed on REACH regulation to search for relevant sections concentrating on nanomaterials which are applicable for nanotechnology. In addition, all relevant directives and amendments of REACH were screened with regard to identify gaps where action is still needed and give possible recommendations for the European Commission. Beyond literature research a questionnaire for producers, users, researchers and financiers was developed with the goal to collect information about the nanotechnology sector in the CE region concerning development, financial status, and international cooperation within joint ventures, safety and nanotoxicology.

  10. Guidance on health effects of toxic chemicals. Safety Analysis Report Update Program

    Energy Technology Data Exchange (ETDEWEB)

    Foust, C.B.; Griffin, G.D.; Munro, N.B.; Socolof, M.L.

    1994-02-01

    Martin Marietta Energy Systems, Inc. (MMES), and Martin Marietta Utility Services, Inc. (MMUS), are engaged in phased programs to update the safety documentation for the existing US Department of Energy (DOE)-owned facilities. The safety analysis of potential toxic hazards requires a methodology for evaluating human health effects of predicted toxic exposures. This report provides a consistent set of health effects and documents toxicity estimates corresponding to these health effects for some of the more important chemicals found within MMES and MMUS. The estimates are based on published toxicity information and apply to acute exposures for an ``average`` individual. The health effects (toxicological endpoints) used in this report are (1) the detection threshold; (2) the no-observed adverse effect level; (3) the onset of irritation/reversible effects; (4) the onset of irreversible effects; and (5) a lethal exposure, defined to be the 50% lethal level. An irreversible effect is defined as a significant effect on a person`s quality of life, e.g., serious injury. Predicted consequences are evaluated on the basis of concentration and exposure time.

  11. Practical management of chemicals and hazardous wastes: An environmental and safety professional`s guide

    Energy Technology Data Exchange (ETDEWEB)

    Kuhre, W.L.

    1995-08-01

    This book was written to help the environmental and safety student learn about the field and to help the working professional manage hazardous material and waste issues. For example, one issue that will impact virtually all of these people mentioned is the upcoming environmental standardization movement. The International Standards Organization (ISO) is in the process of adding comprehensive environmental and hazardous waste management systems to their future certification requirements. Most industries worldwide will be working hard to achieve this new level of environmental management. This book presents many of the systems needed to receive certification. In order to properly manage hazardous waste, it is important to consider the entire life cycle, including when the waste was a useful chemical or hazardous material. Waste minimization is built upon this concept. Understanding the entire life cycle is also important in terms of liability, since many regulations hold generators responsible from cradle to grave. This book takes the life-cycle concept even further, in order to provide additional insight. The discussion starts with the conception of the chemical and traces its evolution into a waste and even past disposal. At this point the story continues into the afterlife, where responsibility still remains.

  12. 典型的IPC漏洞网络入侵分析及防范%Analysis and Protection Based on Typical Network Intrusion of IPC Loopholes

    Institute of Scientific and Technical Information of China (English)

    温海波

    2013-01-01

    This paper analyzes the typical loopholes in the IPC network intrusion attack process. Prevention strategies and methods are given based on researching system strategy, system services, computer port and ect., through coding the batch command script program and injecting it into system registry, running automatically with the system starting, we achieve prevent invasion and safety protection.%该文分析了典型的IPC漏洞网络入侵攻击的过程,从系统策略、系统服务、计算机端口等方面研究,给出了防范策略及方法,通过批处理命令编制脚本程序并注入系统注册表中,使其启动系统时自动运行,实现阻止入侵的安全防护.

  13. [Dissemination of the Japanese version of the International Chemical Safety Card (ICSC) on the World Wide Web (WWW)].

    Science.gov (United States)

    Yamamoto, M; Yokote, N; Morita, M; Nakano, T; Ishikawa, K; Kaminuma, T

    1997-01-01

    ge of the Japanese version of the International Chemical Safety Cards (ICSC). We prepared the Japanese text files of ICSC, converted them into HTML files and also prepared the dictionary database for the retrieval system, using programs which we developed. These programs shortened the time of work remarkably. 2D- and 3D-structures of chemicals were also incorporated in each ICSC page. Approximately 900 ICSCs in Japanese are provided at the moment on the homepage.

  14. Reliability and Validity of the Multidimensional Locus of Control IPC Scale in a Sample of 3668 Greek Educators

    Directory of Open Access Journals (Sweden)

    Ntina Kourmousi

    2015-11-01

    Full Text Available The Multidimensional Locus of Control IPC Scale (IPC LOC Scale is an instrument for assessing the locus of control on adults. The aim of the present study is to translate the IPC LOC Scale and evaluate its reliability and validity in a sample of Greek teachers. Data were collected from a nationwide sample of 3668 educators of all levels and specialties. The Cronbach’s alpha coefficient was used to determine the internal consistency reliability. A confirmatory factor analysis (CFA was conducted in order to test the construct validity of the questionnaire. Validity was further examined by investigating the correlation of the IPC LOC Scale with the Rosenberg self-esteem scale (RSES and its association with several demographic and work-related data. Internal consistency reliability was satisfactory with a Cronbach’s alpha above 0.70 for all LOC dimensions. CFA confirmed that the items composing the three subscales of the IPC LOC Scale measure the same construct. Also, the root mean square error of approximation (RMSEA, the comparative fit index (CFI and the goodness of fit index (GFI values were 0.053, 0.951, and 0.937, respectively for the three-factor model, further confirming the manufacturer’s theory for the three latent variables, Internality, Powerful Others, and Chance. Intercorrelations and correlation coefficients between the IPC LOC Scale and the RSES were significant, while age and sex differences were also found. The Greek version of the IPC LOC Scale was found to have satisfactory psychometric properties and could be used to evaluate the locus of control in Greek teachers.

  15. Controlled Interphase Power Controller (IPC on the Base of Squashed Transformer

    Directory of Open Access Journals (Sweden)

    AMBROS, T.

    2007-11-01

    Full Text Available One of the perspective technical decisions in the field of management of modes of the electrical networks and systems are the Flexible Alternating Power Transmission Systems (FACTS or Power Controllers. Most perspective of them is Interphase Power Controller (IPC on the base of non-controllable phase-shifting transformer with the three working windings connected in 'delta' and constant shifting angle of 600. The analyses of its characteristics and working modes which are done in this paper are shone, then using multi-windings controllable transformer allows essentially to damage the required power of the phase-shifting transformer.

  16. IPC CEMAC2010推出IPC美国专家的精彩讲座

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    2010年3月15—16日,中国电子制造年年(IPC CEMAC)2010将于上海展会期间,在上海推出来自IPC美国的资深专家、IPC技术转让总监Dieter Bergman的精彩讲座,而DieterBergman从事电子行业已有50余年,蜚声中海外业界。

  17. [Managing of platelet transfusion refractoriness of haematological malignancies. Experience IPC-EFSAM].

    Science.gov (United States)

    Dettori, I; Ladaique, P

    2014-11-01

    The platelet refractoriness is a complication of transfusion treatments potentially dramatic in onco-haematology. Chemo-treatment of haematological malignancies or packs of allogeneic bone marrow transplants require iterative platelet transfusion requirements. The discovery of a platelet refractoriness along with its support should be the most reactive as possible but also adapted to the cause. In the case of allo-immunization, it may be expected. The purpose of this presentation is to recall the different etiologies and perform a feedback on the support transfusion platelet of onco-haematology adult patients at Institut Paoli-Calmettes (IPC) in partnership with the EFSAM.

  18. Toxicogenetics: population-based testing of drug and chemical safety in mouse models.

    Science.gov (United States)

    Rusyn, Ivan; Gatti, Daniel M; Wiltshire, Timothy; Wilshire, Timothy; Kleeberger, Steven R; Threadgill, David W

    2010-08-01

    The rapid decline in the cost of dense genotyping is paving the way for new DNA sequence-based laboratory tests to move quickly into clinical practice, and to ultimately help realize the promise of 'personalized' therapies. These advances are based on the growing appreciation of genetics as an important dimension in science and the practice of investigative pharmacology and toxicology. On the clinical side, both the regulators and the pharmaceutical industry hope that the early identification of individuals prone to adverse drug effects will keep advantageous medicines on the market for the benefit of the vast majority of prospective patients. On the environmental health protection side, there is a clear need for better science to define the range and causes of susceptibility to adverse effects of chemicals in the population, so that the appropriate regulatory limits are established. In both cases, most of the research effort is focused on genome-wide association studies in humans where de novo genotyping of each subject is required. At the same time, the power of population-based preclinical safety testing in rodent models (e.g., mouse) remains to be fully exploited. Here, we highlight the approaches available to utilize the knowledge of DNA sequence and genetic diversity of the mouse as a species in mechanistic toxicology research. We posit that appropriate genetically defined mouse models may be combined with the limited data from human studies to not only discover the genetic determinants of susceptibility, but to also understand the molecular underpinnings of toxicity.

  19. Chemical compositional, biological, and safety studies of a novel maple syrup derived extract for nutraceutical applications.

    Science.gov (United States)

    Zhang, Yan; Yuan, Tao; Li, Liya; Nahar, Pragati; Slitt, Angela; Seeram, Navindra P

    2014-07-16

    Maple syrup has nutraceutical potential given the macronutrients (carbohydrates, primarily sucrose), micronutrients (minerals and vitamins), and phytochemicals (primarily phenolics) found in this natural sweetener. We conducted compositional (ash, fiber, carbohydrates, minerals, amino acids, organic acids, vitamins, phytochemicals), in vitro biological, and in vivo safety (animal toxicity) studies on maple syrup extracts (MSX-1 and MSX-2) derived from two declassified maple syrup samples. Along with macronutrient and micronutrient quantification, thirty-three phytochemicals were identified (by HPLC-DAD), and nine phytochemicals, including two new compounds, were isolated and identified (by NMR) from MSX. At doses of up to 1000 mg/kg/day, MSX was well tolerated with no signs of overt toxicity in rats. MSX showed antioxidant (2,2-diphenyl-1-picrylhydrazyl (DPPH) assay) and anti-inflammatory (in RAW 264.7 macrophages) effects and inhibited glucose consumption (by HepG2 cells) in vitro. Thus, MSX should be further investigated for potential nutraceutical applications given its similarity in chemical composition to pure maple syrup.

  20. Water absorption and moisture permeation properties of chitosan/poly(acrylamide-co-itaconic acid) IPC films.

    Science.gov (United States)

    Bajpai, M; Bajpai, S K; Jyotishi, Pooja

    2016-03-01

    In this work, aqueous solutions of chitosan (Ch) and [poly(acrylamide(AAm)-co-itaconicacid(IA)] have been mixed to yield Ch/poly(AAm-co-IA) Inter-polyelectrolyte complex (IPC) films. The films were characterized by FTIR, X-ray diffraction (XRD) and thermo gravimetric analysis (TGA). There was remarkable increase in the crystalline nature of IPC films. The films were investigated for their water absorption capacity in the physiological fluid (PF) of pH 7.4 at 37 °C. The amount of IA present in the film forming solutions affected the water absorption behavior of the resulting films. The dynamic water uptake data were interpreted by various kinetic models. The effect of pH on the swelling ratio (SR) indicated that the films showed highest swelling in lower as well as higher pH media. The water vapor transmission rates (WVTR) were obtained in the range of 6000-6645 g/m(2)/day.

  1. D版IPC-6012《刚性印制板鉴定与性能规范》标准发布

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    近期IPC发布的DY&IPC-6012《刚性印制板鉴定与性能规范》标准,为业界提供了最新的刚性印制板性能要求。此外最新航空、军工电子应用版IPC-6012DS也同期发布。D版IPC-6012的发布,使IPc-6010裸板性能要求系列标准的更新终于画上了阶段性的句号。

  2. Electric Insulation Intelligent Detection System IPC Terminal Design%客车电气绝缘智能检测系统工控机端设计

    Institute of Scientific and Technical Information of China (English)

    丁振凡; 王小明; 吴小元; 邓建明; 周斌

    2012-01-01

    In order to ensure the safety and reliability of the vehicle electrical wiring, a routine work in the railway department is to detect the quality of the various components on the vehicle and find the problem timely. The insulation resistance of a component is an important factor to reflect the quality. In the industrial control terminal, Java was used to implement the application. The detection process is controlled by communication between IPC and SCM. SCM drives the detection pen to detect by send signals. Detection results will be displayed on IPC. The IPC can determine the lower limit of resistance for the detect object and can alarm when receiving abnormal data. Detection results were stored in database. Truth and effectiveness of data can be guaranteed through operational processes of three detections and one verification. Detection report about each vehicle was drawn using iText. Testing range is 1M Ω~10000MΩ. Experimental results show that, the measurement accuracy to ± 2% measurements, measuring the stability of sampling time control in 3~4S, stable data.%为确保车辆电气配线安全可靠,铁路部门的一项常规性工作是对客车上各部件的质量进行检测,及时找出故障点,而部件绝缘电阻是体现材料质量的一项重要因素;工控机端系统用Java技术编程实现;通过工控机与单片机之间的通信控制检测过程,由单片机发送信号驱动检测笔进行检测,检测结果送工控机界面显示,能根据检测对象智能确定其下限电阻,对异常数据及时报警;检测数据记录在数据库中,通过3检1验的操作流程保证检验数据的真实有效性;利用iText组件绘制每个车对应的检测报表;测试量程范围为1MΩ~10000MΩ;实测结果表明,测量精度达到±2%测量值,测量稳定采样时间控制在3~4 s间,数据稳定.

  3. Effect of Sintering Temperature of Mo Skeleton on the Contiguity and Compressive Properties of Mo-Cu IPCs

    Science.gov (United States)

    Liu, Longfei; Cao, Fuhua; Lu, Liwei; Yan, Jianhui

    2017-02-01

    Interpenetrating phase composites (IPCs) are interesting materials, in which each phase can contribute its most desirable attributes to the composite as a whole by its contiguous morphology. In the present study, molybdenum-copper (Mo-Cu) composites with interpenetrating microstructure were fabricated by open-celled porous Mo skeleton with infiltration of Cu. Effects of sintering temperature on the Mo-Mo contiguity and compressive properties of the Mo-Cu IPCs were examined. The contiguity of Mo-Mo and compressive strength increase with the sintering temperature increasing from 1473 to 1873 K, and decrease at 2073 K. Volume fraction of Cu infiltrated in Mo skeleton and failure strain of composites decrease with the sintering temperature increasing from 1473 to 1873 K and increase at 2073 K. Mutual dependency of compressive properties and contiguity of Mo-Cu IPCs are illustrated.

  4. SAFETY

    CERN Multimedia

    M. Plagge, C. Schaefer and N. Dupont

    2013-01-01

    Fire Safety – Essential for a particle detector The CMS detector is a marvel of high technology, one of the most precise particle measurement devices we have built until now. Of course it has to be protected from external and internal incidents like the ones that can occur from fires. Due to the fire load, the permanent availability of oxygen and the presence of various ignition sources mostly based on electricity this has to be addressed. Starting from the beam pipe towards the magnet coil, the detector is protected by flooding it with pure gaseous nitrogen during operation. The outer shell of CMS, namely the yoke and the muon chambers are then covered by an emergency inertion system also based on nitrogen. To ensure maximum fire safety, all materials used comply with the CERN regulations IS 23 and IS 41 with only a few exceptions. Every piece of the 30-tonne polyethylene shielding is high-density material, borated, boxed within steel and coated with intumescent (a paint that creates a thick co...

  5. SAFETY

    CERN Multimedia

    C. Schaefer and N. Dupont

    2013-01-01

      “Safety is the highest priority”: this statement from CERN is endorsed by the CMS management. An interpretation of this statement may bring you to the conclusion that you should stop working in order to avoid risks. If the safety is the priority, work is not! This would be a misunderstanding and misinterpretation. One should understand that “working safely” or “operating safely” is the priority at CERN. CERN personnel are exposed to different hazards on many levels on a daily basis. However, risk analyses and assessments are done in order to limit the number and the gravity of accidents. For example, this process takes place each time you cross the road. The hazard is the moving vehicle, the stake is you and the risk might be the risk of collision between both. The same principle has to be applied during our daily work. In particular, keeping in mind the general principles of prevention defined in the late 1980s. These principles wer...

  6. Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC

    Directory of Open Access Journals (Sweden)

    Silvia eMartin-Puig

    2015-05-01

    Full Text Available Reperfusion of ischemic cardiac tissue is the standard treatment for improving clinical outcome following myocardial infarction but is inevitably associated with ischemia-reperfusion injury (IRI. Ischemic myocardial injury can be alleviated by exposing the heart to brief episodes of sublethal ischemia-reperfusion prior to the ischemic insult, a phenomenon that has been termed ischemic preconditioning (IPC. Similarly, remote IPC (RIPC is defined as transient episodes of ischemia at a distant site before a subsequent prolonged injury of the target organ. In this setting, adaptive responses to hypoxia/ischemia in peripheral tissues include the release of soluble factors that have the potential to protect cardiomyocytes remotely. Oxygen fluctuation is a hallmark of insufficient tissue perfusion and ischemic episodes. Emerging evidence indicates that prolyl hydroxylase oxygen sensors (PHDs and hypoxia-inducible transcription factors (HIFs are critical regulators of IPC and RIPC. In this minireview, we discuss recent findings concerning the role of the PHD-HIF axis in IPC and RIPC-mediated cardioprotection and examine molecular pathways and cell types that might be involved. We also appraise the therapeutic value of targeting the PHD-HIF axis to enhance cardiac tolerance against IRI.

  7. Predicción de los componentes del IPC en la Comunidad de Madrid. Principales cambios metodológicos.

    Directory of Open Access Journals (Sweden)

    Ibar Alonso, Raquel

    2002-01-01

    Full Text Available El IPC con base en el año 2001, ha registrado importantes cambios metodológicos respecto al procedimiento de cálculo del anterior IPC con base 1992. Estos cambios van a permitir que el nuevo Índice de Precios al Consumo refleje mejor cuales son los hábitos de consumo de las familias, las tendencias del mercado y las variaciones que se producen en los precios, mitigándose así los sesgos que tradicionalmente se están produciendo en la medición de los índices de precios. Del mismo modo, con esta nueva metodología, el IPC se aproxima más al los requisitos exigidos de Eurostat y al Índice de Precios Armonizado de Consumo, caracterizándose por ser más moderno y más dinámico. En esta ponencia trataremos de obtener predicciones adecuadas para las tasas mensuales y anuales de los diferentes componentes del IPC, con el fin de realizar un análisis del fenómeno inflacionario en términos de inflación residual y tendencial a través de la creación y utilización de distintos modelos que serán ejecutados con el programa SCA.

  8. Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC.

    Science.gov (United States)

    Martin-Puig, Silvia; Tello, Daniel; Aragonés, Julián

    2015-01-01

    Reperfusion of ischemic cardiac tissue is the standard treatment for improving clinical outcome following myocardial infarction but is inevitably associated with ischemia-reperfusion injury (IRI). Ischemic myocardial injury can be alleviated by exposing the heart to brief episodes of sublethal ischemia-reperfusion prior to the ischemic insult, a phenomenon that has been termed ischemic preconditioning (IPC). Similarly, remote IPC (RIPC) is defined as transient episodes of ischemia at a distant site before a subsequent prolonged injury of the target organ. In this setting, adaptive responses to hypoxia/ischemia in peripheral tissues include the release of soluble factors that have the potential to protect cardiomyocytes remotely. Oxygen fluctuations is a hallmark of insufficient tissue perfusion and ischemic episodes. Emerging evidence indicates that prolyl hydroxylase oxygen sensors (PHDs) and hypoxia-inducible transcription factors (HIFs) are critical regulators of IPC and RIPC. In this review, we discuss recent findings concerning the role of the PHD-HIF axis in IPC and RIPC-mediated cardioprotection and examine molecular pathways and cell types that might be involved. We also appraise the therapeutic value of targeting the PHD-HIF axis to enhance cardiac tolerance against IRI.

  9. 77 FR 76419 - Health and Safety Data Reporting; Addition of Certain Chemicals; Withdrawal of Final Rule

    Science.gov (United States)

    2012-12-28

    ... technical information contact: Mark Seltzer, Chemical Control Division (7405M), Office of Pollution...; telephone number: (202) 564-2901; email address: seltzer.mark@epa.gov or Mike Mattheisen, Chemical...

  10. 40 CFR 799.5115 - Chemical testing requirements for certain chemicals of interest to the Occupational Safety and...

    Science.gov (United States)

    2010-07-01

    .... Unabsorbed chemical must be removed from the skin surface by washing gently with soap and water. This... surface of the skin with soap and water and the amount absorbed into the skin and receptor fluid must be... individuals performing the work and their supervisors. (B) A description of the source, identity, and purity...

  11. Mixed and low-level waste treatment project: Appendix C, Health and safety criteria for the mixed and low-level waste treatment facility at the Idaho National Engineering Laboratory. Part 2, Chemical constituents

    Energy Technology Data Exchange (ETDEWEB)

    Neupauer, R.M.; Thurmond, S.M.

    1992-09-01

    This report contains health and safety information relating to the chemicals that have been identified in the mixed waste streams at the Waste Treatment Facility at the Idaho National Engineering Laboratory. Information is summarized in two summary sections--one for health considerations and one for safety considerations. Detailed health and safety information is presented in material safety data sheets (MSDSs) for each chemical.

  12. Notification: FY 2017 Update of Proposed Key Management Challenges and Internal Control Weaknesses Confronting the U.S. Chemical Safety and Hazard Investigation Board

    Science.gov (United States)

    Jan 5, 2017. The EPA OIG is beginning work to update for fiscal year 2017 its list of proposed key management challenges and internal control weaknesses confronting the U.S. Chemical Safety and Hazard Investigation Board (CSB).

  13. Chemical conditions in present and future ecosystems in Forsmark - implications for selected radionuclides in the safety assessment SR-Site

    Energy Technology Data Exchange (ETDEWEB)

    Troejbom, Mats (Mats Troejbom Konsult AB (Sweden)); Grolander, Sara (Facilia AB (Sweden))

    2010-12-15

    This report is a background report for the biosphere analysis of the SR-Site Safety Assessment. This work aims to describe the future development of the chemical conditions at Forsmark, based on the present chemical conditions at landscape level taking landscape development and climate cases into consideration. The results presented contribute to the overall understanding of the present and future chemistry in the Forsmark area, and specifically, to the understanding of the behaviour of some selected radionuclides in the surface system. The future development of the chemistry at the site is qualitatively discussed with focus on the interglacial within the next 10,000 years. The effects on the chemical environment of future climate cases as Global Warming and cold permafrost climates are also briefly discussed. The work is presented in two independent parts describing background radionuclide activities in the Forsmark area and the distribution and behaviour of a large number of stable elements in the landscape. In a concluding section, implications of the future chemical environment of a selection of radionuclides important in the Safety Assessment are discussed based on the knowledge of stable elements. The broad range of elements studied show that there are general and expected patterns for the distribution and behaviour in the landscape of different groups of elements. Mass balances reveal major sources and sinks, pool estimations show where elements are accumulated in the landscape and estimations of time-scales give indications of the potential future development. This general knowledge is transferred to radionuclides not measured in order to estimate their behaviour and distribution in the landscape. It could be concluded that the future development of the chemical environment in the Forsmark area might affect element specific parameters used in de radionuclide model in different directions depending on element. The alternative climate cases, Global Warming

  14. An integrated approach towards safety during change in the chemical process industry

    NARCIS (Netherlands)

    Gort, J.; Zwetsloot, G.I.J.M.; Lemkowitz, S.; Steijger, N.; Moonen, C.

    2004-01-01

    Increasing global competition and shareholder pressure cause major changes in the chemical industry. Over the last decade companies continuously improve their manpower efficiency. As a result most chemical plants of today can be regarded as lean plants. Plans to further reduce the number of staff

  15. 75 FR 29754 - Claims of Confidentiality of Certain Chemical Identities Contained in Health and Safety Studies...

    Science.gov (United States)

    2010-05-27

    ... address: sherlock.scott@epa.gov . For general information contact: The TSCA-Hotline, ABVI-Goodwill, 422... TSCA Inventory. With respect to such chemical substances, EPA is aware that some companies believe... companies might find such use of a chemical identity undesirable, EPA does not believe that TSCA section 14...

  16. Organic chemical aging mechanisms: An annotated bibliography. Waste Tank Safety Program

    Energy Technology Data Exchange (ETDEWEB)

    Samuels, W.D.; Camaioni, D.M.; Nelson, D.A.

    1993-09-01

    An annotated bibliography has been compiled of the potential chemical and radiological aging mechanisms of the organic constituents (non-ferrocyanide) that would likely be found in the UST at Hanford. The majority of the work that has been conducted on the aging of organic chemicals used for extraction and processing of nuclear materials has been in conjunction with the acid or PUREX type processes. At Hanford the waste being stored in the UST has been stabilized with caustic. The aging factors that were used in this work were radiolysis, hydrolysis and nitrite/nitrate oxidation. The purpose of this work was two-fold: to determine whether or not research had been or is currently being conducted on the species associated with the Hanford UST waste, either as a mixture or as individual chemicals or chemical functionalities, and to determine what areas of chemical aging need to be addressed by further research.

  17. Chemical Contaminants Associated with Palm Wine from Nigeria Are Potential Food Safety Hazards

    Directory of Open Access Journals (Sweden)

    Ogueri Nwaiwu

    2017-03-01

    Full Text Available Recent analysis of palm wine, a traditional drink fermented mainly by yeasts, revealed the presence of several chemicals that were not products of yeast fermentation. The chemicals included styrene, benzene, trimethyldioxolane, dichloromethane, methylene fluoride, dichloroethanol, benzylisoquinoline and tetraacetyl-d-xylonic nitrile. A review of the concentrations of these compounds in palm wine found that the benzene concentrations in all samples reviewed ranged from 56–343 ppm and were within permissible limits, whereas the styrene values (1505–5614 ppm in all the palm wine samples evaluated were well over the recommended concentration that is immediately dangerous to life or health. Other chemical compounds evaluated varied according to location or sample source. The concentrations obtained are estimates only and a quantitative study needs to be carried out before the impact of these chemicals on health is evaluated. A search on The PubChem Project, the open chemical database, showed the description, properties and uses of these chemicals. Further searches carried out within other databases like PubMed, Scopus and Google Scholar, using each chemical’s name as a search term, showed possible hazards and adverse health conditions caused by these chemicals, especially styrene, benzene and dichloromethane. The point at which the chemicals are introduced into the drink is still not clear and requires further investigation. The chemicals can be hazardous to humans and there is need to establish and maintain a system that can guarantee permissible levels in the drink. This can be carried out using concentrations of the chemicals that are already known to be immediately dangerous to life or health as a reference point.

  18. Single-step separation of platelets from whole blood coupled with digital quantification by interfacial platelet cytometry (iPC).

    Science.gov (United States)

    Basabe-Desmonts, L; Ramstrom, S; Meade, G; O'Neill, S; Riaz, A; Lee, L P; Ricco, A J; Kenny, D

    2010-09-21

    We report the efficient single-step separation of individual platelets from unprocessed whole blood, enabling digital quantification of platelet function using interfacial platelet cytometry (iPC) on a chip. iPC is accomplished by the precision micropatterning of platelet-specific protein surfaces on solid substrates. By separating platelets from whole blood using specific binding to protein spots of a defined size, iPC implements a simple incubate-and-rinse approach, without sample preparation, that enables (1) the study of platelets in the physiological situation of interaction with a protein surface, (2) the choice of the number of platelets bound on each protein spot, from one to many, (3) control of the platelet-platelet distance, including the possibility to study noninteracting single platelets, (4) digital quantification (counting) of platelet adhesion to selected protein matrices, enabling statistical characterization of platelet subpopulations from meaningfully large numbers of single platelets, (5) the study of platelet receptor expression and spatial distribution, and (6) a detailed study of the morphology of isolated single platelets at activation levels that can be manipulated. To date, we have demonstrated 1-4 of the above list. Platelets were separated from whole blood using iPC with fibrinogen, von Willebrand factor (VWF), and anti-CD42b antibody printed "spots" ranging from a fraction of one to several platelet diameters (2-24 μm). The number of platelets captured per spot depends strongly on the protein matrix and the surface area of the spot, together with the platelet volume, morphology, and activation state. Blood samples from healthy donors, a May-Hegglin-anomaly patient, and a Glanzmann's Thrombasthenia patient were analyzed via iPC to confirm the specificity of the interaction between protein matrices and platelets. For example, the results indicate that platelets interact with fibrinogen spots only through the fibrinogen receptor (

  19. [Chemical analytical aspects of hygiene safety of the use of methyl tertiary-butyl ether in the production of gasoline].

    Science.gov (United States)

    Malysheva, A G; Rastyannikov, E G; Kozlova, N Yu; Artyushina, I Yu

    2014-01-01

    There was developed, certified and recommended for the practical application the technique for control in the water used as a high-octane oxygenated gasoline additive methyl tert-butyl ether with the use of chromatography-mass spectrometry method with a sensitivity of (0.005 mg/dm3) below the level of existing foreign regulations. Technique is introduced into the Federal Information Fund to ensure the unity of measurements. The possibility of applying the proposed method of analysis for monitoring chemical contamination of water sources and the quality control and safety of drinking water has been shown.

  20. Safety Training for the Developmentally Disabled in Icon Recognition for the Safe Use of Hazardous Chemicals

    Science.gov (United States)

    Sandoz, Jeff

    2005-01-01

    This unique document is a training manual for individuals such as job coaches and janitorial crew supervisors who train and work with Developmentally Disabled (DD) workers in vocational classrooms and on job sites. These workers need to be taught the importance of safety in the workplace using methods appropriate to their developmental needs. The…

  1. Mixtures of chemical pollutants at European legislation safety concentrations: how safe are they?

    DEFF Research Database (Denmark)

    Carvalho, Raquel N.; Arukwe, Augustine; Ait-Aissa, Selim

    2014-01-01

    ) fish embryo toxicity, v) impaired frog embryo development, and vi) increased expression on oxidative stress-linked reporter genes. Estrogenic activity close to regulatory safety limit concentrations was uncovered by receptor-binding assays. The results highlight the need of precautionary actions...

  2. Chemical Compositional, Biological, and Safety Studies of a Novel Maple Syrup Derived Extract for Nutraceutical Applications

    OpenAIRE

    Zhang, Yan; Yuan, Tao; Li, Liya; Nahar, Pragati; Slitt, Angela; Seeram, Navindra P.

    2014-01-01

    Maple syrup has nutraceutical potential given the macronutrients (carbohydrates, primarily sucrose), micronutrients (minerals and vitamins), and phytochemicals (primarily phenolics) found in this natural sweetener. We conducted compositional (ash, fiber, carbohydrates, minerals, amino acids, organic acids, vitamins, phytochemicals), in vitro biological, and in vivo safety (animal toxicity) studies on maple syrup extracts (MSX-1 and MSX-2) derived from two declassified maple syrup samples. Alo...

  3. 29 CFR 1926.64 - Process safety management of highly hazardous chemicals.

    Science.gov (United States)

    2010-07-01

    ... apply to: (i) Retail facilities; (ii) Oil or gas well drilling or servicing operations; or, (iii... built after May 26, 1992; and, (H) Safety systems (e.g. interlocks, detection or suppression systems... interrelationships such as appropriate application of detection methodologies to provide early warning of...

  4. Promoting chemical laboratory safety management in colleges and universities by constructing safety culture%以安全文化建设促进高校化学实验室安全管理

    Institute of Scientific and Technical Information of China (English)

    牛焕双; 张润杰; 刘滨

    2013-01-01

    This paper elaborates on the origin and the connotation of safety culture .Considering the role of safety culture in safety management of chemical laboratory ,the safety culture construction is implemented in chemical laboratory management in colleges and universities .This paper also puts forward the main contents , including safety material culture ,safety system culture ,safety behavior culture and safety spirit culture .The construction of safety culture reflects the people-oriented management concept . And it can inspired the initiative of the teacher and students ,and strengthen their safety consciousness .This will ensure the safety and stability of the chemical laboratory .%阐述了安全文化概念的起源及其内涵,通过分析安全文化在化学实验室安全管理中的作用,提出在高校化学实验室的管理中推行安全文化建设的主要内容,包括安全物质文化、安全制度文化、安全行为文化、安全精神文化4个层次。安全文化建设体现了以人为本的管理理念,能充分调动广大师生的主动性和自觉强化安全的意识,确保化学实验室安全稳定。

  5. Combination of chemical analyses and animal feeding trials as reliable procedures to assess the safety of heat processed soybean seeds.

    Science.gov (United States)

    Vasconcelos, Ilka M; Brasil, Isabel Cristiane F; Oliveira, José Tadeu A; Campello, Cláudio C; Maia, Fernanda Maria M; Campello, Maria Verônica M; Farias, Davi F; Carvalho, Ana Fontenele U

    2009-06-10

    This study assessed whether chemical analyses are sufficient to guarantee the safety of heat processing of soybeans (SB) for human/animal consumption. The effects of extrusion and dry-toasting were analyzed upon seed composition and performance of broiler chicks. None of these induced appreciable changes in protein content and amino acid composition. Conversely, toasting reduced all antinutritional proteins by over 85%. Despite that, the animals fed on toasted SB demonstrated a low performance (feed efficiency 57.8 g/100 g). Extrusion gave place to higher contents of antinutrients, particularly of trypsin inhibitors (27.53 g/kg flour), but animal performance was significantly (p trials, extrusion appears to be the safest method. In conclusion, in order to evaluate the reliability of any processing method intended to improve nutritional value, the combination of chemical and animal studies is necessary.

  6. "You Pulled Me out of a Dark Well": A Case Study of a Colombian Displaced Woman Empowered Through Interpersonal Counseling (IPC).

    Science.gov (United States)

    Ceballos, Angela Milena Gomez; Andrade, Ana Claudia; Markowitz, Talia; Verdeli, Helen

    2016-08-01

    Interpersonal counseling (IPC), a briefer and simplified adaptation of interpersonal psychotherapy (IPT), was used with internally displaced women (IDW) in Bogotá, Colombia, an implementation study of a mental health care pathway funded by Grand Challenges Canada. Preliminary evidence suggests that IPC led to positive outcomes for IDW and may be a feasible first line treatment for displaced women with elevated symptoms of common mental disorders. The case study demonstrates the use of IPC as an intervention to treat depression, anxiety, and posttraumatic stress symptoms in one participant across 11 sessions, from the case formulation through the termination phase.

  7. The Einstein database of IPC x-ray observations of optically selected and radio-selected quasars, 1.

    Science.gov (United States)

    Wilkes, Belinda J.; Tananbaum, Harvey; Worrall, D. M.; Avni, Yoram; Oey, M. S.; Flanagan, Joan

    1994-01-01

    We present the first volume of the Einstein quasar database. The database includes estimates of the X-ray count rates, fluxes, and luminosities for 514 quasars and Seyfert 1 galaxies observed with the Imaging Proportional Counter (IPC) aboard the Einstein Observatory. All were previously known optically selected or radio-selected objects, and most were the targets of the X-ray observations. The X-ray properties of the Active Galactic Nuclei (AGNs) have been derived by reanalyzing the IPC data in a systematic manner to provide a uniform database for general use by the astronomical community. We use the database to extend earlier quasar luminosity studies which were made using only a subset of the currently available data. The database can be accessed on internet via the SAO Einstein on-line system ('Einline') and is available in ASCII format on magnetic tape and DOS diskette.

  8. Do code of conduct audits improve chemical safety in garment factories? Lessons on corporate social responsibility in the supply chain from Fair Wear Foundation.

    Science.gov (United States)

    Lindholm, Henrik; Egels-Zandén, Niklas; Rudén, Christina

    2016-10-01

    In managing chemical risks to the environment and human health in supply chains, voluntary corporate social responsibility (CSR) measures, such as auditing code of conduct compliance, play an important role. To examine how well suppliers' chemical health and safety performance complies with buyers' CSR policies and whether audited factories improve their performance. CSR audits (n = 288) of garment factories conducted by Fair Wear Foundation (FWF), an independent non-profit organization, were analyzed using descriptive statistics and statistical modeling. Forty-three per cent of factories did not comply with the FWF code of conduct, i.e. received remarks on chemical safety. Only among factories audited 10 or more times was there a significant increase in the number of factories receiving no remarks. Compliance with chemical safety requirements in garment supply chains is low and auditing is statistically correlated with improvements only at factories that have undergone numerous audits.

  9. Topical Backgrounder: Chemical Safety in Your Community: EPA's New Risk Management Program

    Science.gov (United States)

    This May 1999 document is part of a series of publications on the RMP and issues related to chemical emergency management. Explains how the RMP requirements pick up where the Emergency Planning and Community Right-to-Know Act left off.

  10. Antioxidant capacity versus chemical safety of wheat bread enriched with pomegranate peel powder

    DEFF Research Database (Denmark)

    Altunkaya, Arzu; Hedegaard, Rikke Susanne Vingborg; Brimer, Leon

    2013-01-01

    electron spin resonance (ESR) spectroscopy, and peroxide value, and the highest capacity of scavenging of radicals (Fremy's salt) and the lowest content of peroxide values were found in bread with the highest percentage of PP. Safety evaluation was performed by the Artemia salina assay. An increased death...... in antioxidant levels expressed as Trolox equivalent antioxidant capacity values (TEAC) ranging from 1.8 to 6.8 µmol TEAC per g bread for fresh bread. TEAC remained constant during 5 days of storage in polyethylene bags at room temperature. The oxidative stability was evaluated by detection of radicals by direct...

  11. Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation.

    Science.gov (United States)

    Shinde, Vaibhav; Klima, Stefanie; Sureshkumar, Perumal Srinivasan; Meganathan, Kesavan; Jagtap, Smita; Rempel, Eugen; Rahnenführer, Jörg; Hengstler, Jan Georg; Waldmann, Tanja; Hescheler, Jürgen; Leist, Marcel; Sachinidis, Agapios

    2015-06-17

    Efficient protocols to differentiate human pluripotent stem cells to various tissues in combination with -omics technologies opened up new horizons for in vitro toxicity testing of potential drugs. To provide a solid scientific basis for such assays, it will be important to gain quantitative information on the time course of development and on the underlying regulatory mechanisms by systems biology approaches. Two assays have therefore been tuned here for these requirements. In the UKK test system, human embryonic stem cells (hESC) (or other pluripotent cells) are left to spontaneously differentiate for 14 days in embryoid bodies, to allow generation of cells of all three germ layers. This system recapitulates key steps of early human embryonic development, and it can predict human-specific early embryonic toxicity/teratogenicity, if cells are exposed to chemicals during differentiation. The UKN1 test system is based on hESC differentiating to a population of neuroectodermal progenitor (NEP) cells for 6 days. This system recapitulates early neural development and predicts early developmental neurotoxicity and epigenetic changes triggered by chemicals. Both systems, in combination with transcriptome microarray studies, are suitable for identifying toxicity biomarkers. Moreover, they may be used in combination to generate input data for systems biology analysis. These test systems have advantages over the traditional toxicological studies requiring large amounts of animals. The test systems may contribute to a reduction of the costs for drug development and chemical safety evaluation. Their combination sheds light especially on compounds that may influence neurodevelopment specifically.

  12. Investigation of discharged aerosol nanoparticles during chemical precipitation and spray pyrolysis for developing safety measures in the nano research laboratory.

    Science.gov (United States)

    Kolesnikov, Еvgeny; Karunakaran, Gopalu; Godymchuk, Anna; Vera, Levina; Yudin, Andrey Grigorjevich; Gusev, Alexander; Kuznetsov, Denis

    2017-05-01

    Nowadays, the demands for the nanoparticles are increasing due to their tremendous applications in various fields. As a consequence, the discharge of nanoparticles into the atmosphere and environment is also increasing, posing a health threat and environmental damage in terms of pollution. Thus, an extensive research is essential to evaluate the discharge of these nanoparticles into the environment. Keeping this in mind, the present investigation aimed to analyze the discharge of aerosol nanoparticles that are synthesized in the laboratory via chemical precipitation and spray pyrolysis methods. The results indicated that the chemical precipitation method discharges a higher concentration of nanoparticles in the work site when compared to the spray pyrolysis method. The aerosol concentration also varied with the different steps involved during the synthesis of nanoparticles. The average particle's concentration in air for chemical precipitation and spray pyrolysis methods was around 1,037,476 and 883,421particles/cm(3). In addition, the average total discharge of nanoparticles in the entire laboratory was also examined. A significant variation in the concentration of nanoparticles was noticed, during the processing of materials and the concentration of particles (14-723nm) exceeding the daily allowed concentration to about 70-170 times was observed over a period of 6 months. Thus, the results of the present study will be very useful in developing safety measures and would help in organizing the rules for people working in nanotechnology laboratories to minimize the hazardous effects. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Chemical and genetic characterization of bacteriocins: antimicrobial peptides for food safety.

    Science.gov (United States)

    Snyder, Abigail B; Worobo, Randy W

    2014-01-15

    Antimicrobial peptides are produced across all domains of life. Among these diverse compounds, those produced by bacteria have been most successfully applied as agents of biocontrol in food and agriculture. Bacteriocins are ribosomally synthesized, proteinaceous compounds that inhibit the growth of closely related bacteria. Even within the subcategory of bacteriocins, the peptides vary significantly in terms of the gene cluster responsible for expression, and chemical and structural composition. The polycistronic gene cluster generally includes a structural gene and various combinations of immunity, secretion, and regulatory genes and modifying enzymes. Chemical variation can exist in amino acid identity, chain length, secondary and tertiary structural features, as well as specificity of active sites. This diversity posits bacteriocins as potential antimicrobial agents with a range of functions and applications. Those produced by food-grade bacteria and applied in normally occurring concentrations can be used as GRAS-status food additives. However, successful application requires thorough characterization.

  14. Hydrogen Safety Project chemical analysis support task: Window C'' volatile organic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Gillespie, B.M.; Stromatt, R.W.; Ross, G.A.; Hoope, E.A.

    1992-01-01

    This data package contains the results obtained by Pacific Northwest Laboratory (PNL) staff in the characterization of samples for the 101-SY Hydrogen Safety Project. The samples were submitted for analysis by Westinghouse Hanford Company (WHC) under the Technical Project Plan (TPP) 17667 and the Quality Assurance Plan MCS-027. They came from a core taken during Window C'' after the May 1991 gas release event. The analytical procedures required for analysis were defined in the Test Instructions (TI) prepared by the PNL 101-SY Analytical Chemistry Laboratory (ACL) Project Management Office in accordance with the TPP and the QA Plan. The requested analysis for these samples was volatile organic analysis. The quality control (QC) requirements for each sample are defined in the Test Instructions for each sample. The QC requirements outlined in the procedures and requested in the WHC statement of work were followed.

  15. Hydrogen Safety Project chemical analysis support task: Window ``C`` volatile organic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Gillespie, B.M.; Stromatt, R.W.; Ross, G.A.; Hoope, E.A.

    1992-01-01

    This data package contains the results obtained by Pacific Northwest Laboratory (PNL) staff in the characterization of samples for the 101-SY Hydrogen Safety Project. The samples were submitted for analysis by Westinghouse Hanford Company (WHC) under the Technical Project Plan (TPP) 17667 and the Quality Assurance Plan MCS-027. They came from a core taken during Window ``C`` after the May 1991 gas release event. The analytical procedures required for analysis were defined in the Test Instructions (TI) prepared by the PNL 101-SY Analytical Chemistry Laboratory (ACL) Project Management Office in accordance with the TPP and the QA Plan. The requested analysis for these samples was volatile organic analysis. The quality control (QC) requirements for each sample are defined in the Test Instructions for each sample. The QC requirements outlined in the procedures and requested in the WHC statement of work were followed.

  16. Chemical and Physical Properties, Safety and Application of Partially Hydrolized Guar Gum as Dietary Fiber

    OpenAIRE

    2007-01-01

    The ideal water-soluble dietary fiber for the fiber-enrichment of foods must be very low in viscosity, tasteless, odorless, and should produce clear solutions in beverages. Partially hydrolyzed guar gum (PHGG) produced from guar gum by enzymatic process has the same chemical structure with intact guar gum but less than one-tenth the original molecular length of guar gum, which make available to be used as film former, foam stabilizer and swelling agent. The viscosity of PHGG is about 10 mPa·s...

  17. Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment.

    Science.gov (United States)

    Wink, Steven; Hiemstra, Steven; Huppelschoten, Suzanna; Danen, Erik; Niemeijer, Marije; Hendriks, Giel; Vrieling, Harry; Herpers, Bram; van de Water, Bob

    2014-03-17

    Over the past decade, major leaps forward have been made on the mechanistic understanding and identification of adaptive stress response landscapes underlying toxic insult using transcriptomics approaches. However, for predictive purposes of adverse outcome several major limitations in these approaches exist. First, the limited number of samples that can be analyzed reduces the in depth analysis of concentration-time course relationships for toxic stress responses. Second these transcriptomics analysis have been based on the whole cell population, thereby inevitably preventing single cell analysis. Third, transcriptomics is based on the transcript level, totally ignoring (post)translational regulation. We believe these limitations are circumvented with the application of high content analysis of relevant toxicant-induced adaptive stress signaling pathways using bacterial artificial chromosome (BAC) green fluorescent protein (GFP) reporter cell-based assays. The goal is to establish a platform that incorporates all adaptive stress pathways that are relevant for toxicity, with a focus on drug-induced liver injury. In addition, cellular stress responses typically follow cell perturbations at the subcellular organelle level. Therefore, we complement our reporter line panel with reporters for specific organelle morphometry and function. Here, we review the approaches of high content imaging of cellular adaptive stress responses to chemicals and the application in the mechanistic understanding and prediction of chemical toxicity at a systems toxicology level.

  18. High-throughput Raman chemical imaging for evaluating food safety and quality

    Science.gov (United States)

    Qin, Jianwei; Chao, Kuanglin; Kim, Moon S.

    2014-05-01

    A line-scan hyperspectral system was developed to enable Raman chemical imaging for large sample areas. A custom-designed 785 nm line-laser based on a scanning mirror serves as an excitation source. A 45° dichroic beamsplitter reflects the laser light to form a 24 cm x 1 mm excitation line normally incident on the sample surface. Raman signals along the laser line are collected by a detection module consisting of a dispersive imaging spectrograph and a CCD camera. A hypercube is accumulated line by line as a motorized table moves the samples transversely through the laser line. The system covers a Raman shift range of -648.7-2889.0 cm-1 and a 23 cm wide area. An example application, for authenticating milk powder, was presented to demonstrate the system performance. In four minutes, the system acquired a 512x110x1024 hypercube (56,320 spectra) from four 47-mm-diameter Petri dishes containing four powder samples. Chemical images were created for detecting two adulterants (melamine and dicyandiamide) that had been mixed into the milk powder.

  19. Validation of Bioreactor and Human-on-a-Chip Devices for Chemical Safety Assessment.

    Science.gov (United States)

    Rebelo, Sofia P; Dehne, Eva-Maria; Brito, Catarina; Horland, Reyk; Alves, Paula M; Marx, Uwe

    2016-01-01

    Equipment and device qualification and test assay validation in the field of tissue engineered human organs for substance assessment remain formidable tasks with only a few successful examples so far. The hurdles seem to increase with the growing complexity of the biological systems, emulated by the respective models. Controlled single tissue or organ culture in bioreactors improves the organ-specific functions and maintains their phenotypic stability for longer periods of time. The reproducibility attained with bioreactor operations is, per se, an advantage for the validation of safety assessment. Regulatory agencies have gradually altered the validation concept from exhaustive "product" to rigorous and detailed process characterization, valuing reproducibility as a standard for validation. "Human-on-a-chip" technologies applying micro-physiological systems to the in vitro combination of miniaturized human organ equivalents into functional human micro-organisms are nowadays thought to be the most elaborate solution created to date. They target the replacement of the current most complex models-laboratory animals. Therefore, we provide here a road map towards the validation of such "human-on-a-chip" models and qualification of their respective bioreactor and microchip equipment along a path currently used for the respective animal models.

  20. Hydration and chemical ingredients in sport drinks: food safety in the European context.

    Science.gov (United States)

    Urdampilleta, Aritz; Gómez-Zorita, Saioa; Soriano, José M; Martínez-Sanz, José M; Medina, Sonia; Gil-Izquierdo, Angel

    2015-05-01

    Before, during and after physical activity, hydration is a limiting factor in athletic performance. Therefore, adequate hydration provides benefits for health and performance of athletes. Besides, hydration is associated to the intake of carbohydrates, protein, sodium, caffeine and other substances by different dietary aids, during the training and/or competition by athletes. These requirements have led to the development of different products by the food industry, to cover the nutritional needs of athletes. Currently in the European context, the legal framework for the development of products, substances and health claims concerning to sport products is incomplete and scarce. Under these conditions, there are many products with different ingredients out of European Food Safety Authority (EFSA) control where claims are wrong due to no robust scientific evidence and it can be dangerous for the health. Further scientific evidence should be constructed by new clinical trials in order to assist to the Experts Commitees at EFSA for obtaining robust scientific opinions concerning to the functional foods and the individual ingredients for sport population.

  1. Microbial and chemical safety of non-commercially packaged water stored for emergency use.

    Science.gov (United States)

    Gerla, Stephanie R; Lloyd, Michelle A; Eggett, Dennis L; Pike, Oscar A

    2015-09-01

    Water storage is one of the most important components of emergency preparedness. Potable water is needed for ensuring the survival and well-being of disaster victims. Consumers may store water in previously used beverage or other food-grade containers for emergency use; however, this practice poses potential safety risks. Water stored in various containers for emergency purposes in residences within the state of Utah was tested for various contaminants. Of 240 samples, seven contained coliforms and 14 samples had free chlorine levels over the Environmental Protection Agency (EPA) 4 parts per million limit. There was a negative correlation between chlorine levels and age of water. The probability that a container had free chlorine present decreased by 4% for each month of storage, suggesting the importance of preventing subsequent contamination of water during storage and use. Water in clear polyethylene terephthalate plastic soda bottles (n=16), even when stored for >18 months, did not exceed 0.3 parts per billion (ppb) antimony, a level significantly lower than the EPA limit of 6.0 ppb antimony. These results support the practice of utilizing previously used containers, when properly cleaned and chlorinated, for emergency water storage.

  2. Farm Health and Safety

    Science.gov (United States)

    ... jobs in the United States. Farms have many health and safety hazards, including Chemicals and pesticides Machinery, ... equipment can also reduce accidents. Occupational Safety and Health Administration

  3. Chemical effects head-loss research in support of generic safety issue 191.

    Energy Technology Data Exchange (ETDEWEB)

    Park, J. H.; Kasza, K.; Fisher, B.; Oras, J.; Natesan, K.; Shack, W. J.; Nuclear Engineering Division

    2006-10-31

    This summary report describes studies conducted at Argonne National Laboratory on the potential for chemical effects on head loss across sump screens. Three different buffering solutions were used for these tests: trisodium phosphate (TSP), sodium hydroxide, and sodium tetraborate. These pH control agents used following a LOCA at a nuclear power plant show various degrees of interaction with the insulating materials Cal-Sil and NUKON. Results for Cal-Sil dissolution tests in TSP solutions, settling rate tests of calcium phosphate precipitates, and benchmark tests in chemically inactive environments are also presented. The dissolution tests were intended to identify important environmental variables governing both calcium dissolution and subsequent calcium phosphate formation over a range of simulated sump pool conditions. The results from the dissolution testing were used to inform both the head loss and settling test series. The objective of the head loss tests was to assess the head loss produced by debris beds created by Cal-Sil, fibrous debris, and calcium phosphate precipitates. The effects of both the relative arrival time of the precipitates and insulation debris and the calcium phosphate formation process were specifically evaluated. The debris loadings, test loop flow rates, and test temperature were chosen to be reasonably representative of those expected in plants with updated sump screen configurations, although the approach velocity of 0.1 ft/s used for most of the tests is 3-10 times that expected in plants with large screens . Other variables were selected with the intent to reasonably bound the head loss variability due to arrival time and calcium phosphate formation uncertainty. Settling tests were conducted to measure the settling rates of calcium phosphate precipitates (formed by adding dissolved Ca to boric acid and TSP solutions) in water columns having no bulk directional flow. For PWRs where NaOH and sodium tetraborate are used to control

  4. Artisanal alcohol production in Mayan Guatemala: Chemical safety evaluation with special regard to acetaldehyde contamination

    Energy Technology Data Exchange (ETDEWEB)

    Kanteres, Fotis [Centre for Addiction and Mental Health (CAMH), 33 Russell Street, ARF 2035, Toronto, ON, Canada, M5S 2 S1 (Canada); Rehm, Juergen [Centre for Addiction and Mental Health (CAMH), 33 Russell Street, ARF 2035, Toronto, ON, Canada, M5S 2 S1 (Canada); Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, ON, Canada, M5T 3 M7 (Canada); Institute for Clinical Psychology and Psychotherapy, TU Dresden, Chemnitzer Strasse 46, D-01187 Dresden (Germany); Lachenmeier, Dirk W., E-mail: Lachenmeier@web.de [Chemisches und Veterinaeruntersuchungsamt (CVUA) Karlsruhe, Weissenburger Strasse 3, D-76187 Karlsruhe (Germany)

    2009-11-01

    There is a lack of knowledge regarding the composition, production, distribution, and consumption of artisanal alcohol, particularly in the developing world. In Nahuala, an indigenous Mayan municipality located in highland Guatemala, heavy alcohol consumption appears to have had a significant negative impact on health, a major role in cases of violence and domestic abuse, and a link to street habitation. Cuxa, an artisanally, as well as commercially produced sugarcane alcohol, is widely consumed by heavy drinkers in this community. Cuxa samples from all distribution points in the community were obtained and chemically analyzed for health-relevant constituents and contaminants including methanol, acetaldehyde, higher alcohols, and metals. From those, only acetaldehyde was confirmed to be present in unusually high levels (up to 126 g/hl of pure alcohol), particularly in samples that were produced clandestinely. Acetaldehyde has been evaluated as 'possibly carcinogenic' and has also been identified as having significant human exposure in a recent risk assessment. This study explores the reasons for the elevated levels of acetaldehyde, through both sampling and analyses of raw and intermediary products of cuxa production, as well as interviews from producers of the clandestine alcohol. For further insight, we experimentally produced this alcohol in our laboratory, based on the directions provided by the producers, as well as materials from the town itself. Based on these data, the origin of the acetaldehyde contamination appears to be due to chemical changes induced during processing, with the major causative factors consisting of poor hygiene, aerobic working conditions, and inadequate yeast strains, compounded by flawed distillation methodology that neglects separation of the first fractions of the distillate. These results indicate a preventable public health concern for consumers, which can be overcome through education about good manufacturing practices

  5. Automated Patent Categorization and Guided Patent Search using IPC as Inspired by MeSH and PubMed.

    Science.gov (United States)

    Eisinger, Daniel; Tsatsaronis, George; Bundschus, Markus; Wieneke, Ulrich; Schroeder, Michael

    2013-04-15

    Document search on PubMed, the pre-eminent database for biomedical literature, relies on the annotation of its documents with relevant terms from the Medical Subject Headings ontology (MeSH) for improving recall through query expansion. Patent documents are another important information source, though they are considerably less accessible. One option to expand patent search beyond pure keywords is the inclusion of classification information: Since every patent is assigned at least one class code, it should be possible for these assignments to be automatically used in a similar way as the MeSH annotations in PubMed. In order to develop a system for this task, it is necessary to have a good understanding of the properties of both classification systems. This report describes our comparative analysis of MeSH and the main patent classification system, the International Patent Classification (IPC). We investigate the hierarchical structures as well as the properties of the terms/classes respectively, and we compare the assignment of IPC codes to patents with the annotation of PubMed documents with MeSH terms.Our analysis shows a strong structural similarity of the hierarchies, but significant differences of terms and annotations. The low number of IPC class assignments and the lack of occurrences of class labels in patent texts imply that current patent search is severely limited. To overcome these limits, we evaluate a method for the automated assignment of additional classes to patent documents, and we propose a system for guided patent search based on the use of class co-occurrence information and external resources.

  6. Automated Patent Categorization and Guided Patent Search using IPC as Inspired by MeSH and PubMed

    Science.gov (United States)

    2013-01-01

    Document search on PubMed, the pre-eminent database for biomedical literature, relies on the annotation of its documents with relevant terms from the Medical Subject Headings ontology (MeSH) for improving recall through query expansion. Patent documents are another important information source, though they are considerably less accessible. One option to expand patent search beyond pure keywords is the inclusion of classification information: Since every patent is assigned at least one class code, it should be possible for these assignments to be automatically used in a similar way as the MeSH annotations in PubMed. In order to develop a system for this task, it is necessary to have a good understanding of the properties of both classification systems. This report describes our comparative analysis of MeSH and the main patent classification system, the International Patent Classification (IPC). We investigate the hierarchical structures as well as the properties of the terms/classes respectively, and we compare the assignment of IPC codes to patents with the annotation of PubMed documents with MeSH terms. Our analysis shows a strong structural similarity of the hierarchies, but significant differences of terms and annotations. The low number of IPC class assignments and the lack of occurrences of class labels in patent texts imply that current patent search is severely limited. To overcome these limits, we evaluate a method for the automated assignment of additional classes to patent documents, and we propose a system for guided patent search based on the use of class co-occurrence information and external resources. PMID:23734562

  7. Separation and Detection of Lanthanide Ions with Nitrilotri (methylenephosphonic) Acid as Complexing Agent and Eluent by IPC

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A mixture containing eleven lanthanide ions was separated and detected on an anion-exchange co-lumn by ion chromatography with indirect photometry detection (IPC).An aqueous solution of 1.5×10-2mol/L nitrilotri(methylenephosphonic) acid and 2.5×10-3mol/L tiron was used as the eluent in which the former served as complexing agent and eluent,the latter played as color reagent and eluent.The effects of acidity,concentration and composition of eluent on the retention behavior of the analytes and detection sensitivity are discussed.

  8. Introduction and summary of the 13th meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): alternative testing methodologies.

    OpenAIRE

    Stokes, W S; Marafante, E

    1998-01-01

    A workshop on alternative toxicological testing methodologies was convened by the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC) 26-31 January 1997 in Ispra, Italy, at the European Centre for the Validation of Alternative Methods. The purpose of the workshop was to assess the current status of alternative testing methodologies available to evaluate adverse human health and environmental effects of chemicals. Another objective of the workshop was to identify...

  9. 化工安全事故的发生与预防措施∗%Discussion on Chemical Safety Accidents and Preventive Measures

    Institute of Scientific and Technical Information of China (English)

    刘瑾; 孙宾宾

    2016-01-01

    结合近年来化工安全事故发生的现状,对引发化工安全事故的常见原因进行了分析,譬如化工生产过程的不规范操作,化工产品储运中的不当操作,部分化学化工实验室安全意识淡漠,通过快递公司邮寄化学试剂存在很大安全隐患,个别不良商家的投机取利行为等,并针对性地提出了一些预防事故发生的措施,譬如促进化工企业从人口聚集区向外迁移,加强石化企业人员安全教育,加强化学化工实验室安全教育,规范邮寄快递化学试剂商业行为,加大化工企业生产过程检查力度等。%Based on the present situation of chemical safety accidents in recent years, the common reasons which led to chemical accidents were analyzed, such as the non-standard operations in chemical production process, the improper operation in storage and transportation of chemical products, the indifference of safety consciousness in some chemical laboratory, the hidden safe trouble by express mail chemical reagent, the excessive speculation of undesirable businessman et al. Some targeted measures were put forward to prevent the accidents, such as promoting chemical enterprise outward from the population accumulation area, strengthening safety education in the petrochemical enterprise and chemical laboratory, regulating the behavior of mail delivery chemicals business, increasing the check of chemical enterprise, and so on.

  10. Validation in Support of Internationally Harmonised OECD Test Guidelines for Assessing the Safety of Chemicals.

    Science.gov (United States)

    Gourmelon, Anne; Delrue, Nathalie

    Ten years elapsed since the OECD published the Guidance document on the validation and international regulatory acceptance of test methods for hazard assessment. Much experience has been gained since then in validation centres, in countries and at the OECD on a variety of test methods that were subjected to validation studies. This chapter reviews validation principles and highlights common features that appear to be important for further regulatory acceptance across studies. Existing OECD-agreed validation principles will most likely generally remain relevant and applicable to address challenges associated with the validation of future test methods. Some adaptations may be needed to take into account the level of technique introduced in test systems, but demonstration of relevance and reliability will continue to play a central role as pre-requisite for the regulatory acceptance. Demonstration of relevance will become more challenging for test methods that form part of a set of predictive tools and methods, and that do not stand alone. OECD is keen on ensuring that while these concepts evolve, countries can continue to rely on valid methods and harmonised approaches for an efficient testing and assessment of chemicals.

  11. Chemical and physical properties, safety and application of partially hydrolized guar gum as dietary fiber.

    Science.gov (United States)

    Yoon, Seon-Joo; Chu, Djong-Chi; Raj Juneja, Lekh

    2008-01-01

    The ideal water-soluble dietary fiber for the fiber-enrichment of foods must be very low in viscosity, tasteless, odorless, and should produce clear solutions in beverages. Partially hydrolyzed guar gum (PHGG) produced from guar gum by enzymatic process has the same chemical structure with intact guar gum but less than one-tenth the original molecular length of guar gum, which make available to be used as film former, foam stabilizer and swelling agent. The viscosity of PHGG is about 10 mPa.s in 5% aqueous solution, whereas 1% solution of guar gum shows range from 2,000 to 3,000 mPa.s. In addition, PHGG is greatly stable against low pH, heat, acid and digestive enzyme. For these reasons, PHGG seems to be one of the most beneficial dietary fiber materials. It also showed that interesting physiological functions still fully exert the nutritional function of a dietary fiber. PHGG has, therefore, been used primarily for a nutritional purpose and became fully integrated food material without altering the rheology, taste, texture and color of final products. PHGG named as Benefiber(R) in USA has self-affirmation on GRAS status of standard grade PHGG. PHGG named as Sunfiber(R) is now being used in various beverages, food products and medicinal foods as a safe, natural and functional dietary fiber in all over the world.

  12. Singularity-conquering ZG controllers of z2g1 type for tracking control of the IPC system

    Science.gov (United States)

    Zhang, Yunong; Yu, Xiaotian; Yin, Yonghua; Peng, Chen; Fan, Zhengping

    2014-09-01

    With wider investigations and applications of autonomous robotics and intelligent vehicles, the inverted pendulum on a cart (IPC) system has become more attractive for numerous researchers due to its concise and representative structure. In this article, the tracking-control problem of the IPC system is considered and investigated. Based on Zhang dynamics (ZD) and gradient dynamics (GD), a novel kind of ZG controllers are developed and investigated for achieving the tracking-control purpose, which contains controllers of z2g0 and z2g1 types according to the number of times of using the ZD and GD methods. Besides, theoretical analyses are presented to guarantee the global and exponential convergence performance of both z2g0 and z2g1 controllers. Computer simulations are further performed to substantiate the feasibility and effectiveness of ZG controllers. More importantly, comparative simulation results demonstrate that controllers of z2g1 type can conquer the singularity problem (i.e. the division-by-zero problem).

  13. Risk Analysis and Safety Protection of Chemical Cleaning of Boiler%锅炉化学清洗的危险性分析及安全防护

    Institute of Scientific and Technical Information of China (English)

    蔡丽霞

    2015-01-01

    本文针对锅炉化学清洗中存在的危险性进行分析,讲述了化学药剂的危害,提出了组织协调与环境控制的重要性,并从锅炉化学清洗前、化学清洗过程及施工环境三个方面说明了锅炉化学清洗的安全防护措施,以有效地预防事故的发生。%This paper analyzes the existent risk in chemical cleaning of boiler, tells the hazards of chemicals, raises the importance of organizational coordination and environmental controls, and describes the safety protection measures of boiler’s chemical cleaning in terms of before the boiler chemical cleaning, chemical cleaning process and the working environment.

  14. A new family of two-dimensional zeolites prepared from the intermediate layered precursor IPC-3P obtained during the synthesis of TUN zeolite.

    Science.gov (United States)

    Kubů, Martin; Roth, Wieslaw J; Greer, Heather F; Zhou, Wuzong; Morris, Russell E; Přech, Jan; Čejka, Jiří

    2013-10-04

    The crystallization of zeolite TUN with 1,4-bis(N-methylpyrrolidinium)butane as template proceeds through an intermediate, designated IPC-3P, following the Ostwald rule of successive transformations. This apparently layered transient product has been thoroughly investigated and found to consist of MWW monolayers stacked without alignment in register, that is, disordered compared with MCM-22P. The structure was confirmed based on X-ray diffraction and high-resolution (HR)TEM analysis. The layered zeolite precursor IPC-3P can be swollen and pillared affording a combined micro- and mesoporous material with enhanced Brunauer-Emmett-Teller (BET) surface area (685 m(2) g(-1) ) and greater accessibility of Brønsted acid sites for bulky molecules. This mesoporous material was probed with 2,6-di-tert-butylpyridine (DTBP). IPC-3P and its modification create a new layered zeolite sub-family belonging to the MWW family. FTIR data indicate that (Al)MWW materials MCM-22 and IPC-3 with Si/Al ratios greater than 20 exhibit a lower relative ratio of Brønsted to Lewis acid sites than MCM-22 (with Si/Al ratios of around 13), that is, less than 2 versus more than 3, respectively. This is maintained even upon pillaring and warrants further exploration of materials like IPC-3P with a higher Al content. The unique XRD features of IPC-3P indicating misaligned stacking of layers and distinct from MCM-22P, are also seen in other MWW materials such as EMM-10P, hexamethonium-templated (HM)-MCM-22, ITQ-30, and UZM-8 suggesting the need for more detailed study of their identity and properties.

  15. Modeling safety in a distributed technology management environment for more cost-effective conceptual design of chemical process plants

    NARCIS (Netherlands)

    Schupp, B.A.; Lemkowitz, S.M.; Goossens, L.H.J.; Hale, A.R.; Pasman, H.J.

    2002-01-01

    Profitability of the CPI can improve by better integrating safety into the design process. At present, conceptual desgners lack means to design safety. This paper discusses a methodology, Design for Safety (DFS), that strives to provide these. It consists of two major concepts. A technology

  16. Modeling safety in a distributed technology management environment for more cost-effective conceptual design of chemical process plants

    NARCIS (Netherlands)

    Schupp, B.A.; Lemkowitz, S.M.; Goossens, L.H.J.; Hale, A.R.; Pasman, H.J.

    2002-01-01

    Profitability of the CPI can improve by better integrating safety into the design process. At present, conceptual desgners lack means to design safety. This paper discusses a methodology, Design for Safety (DFS), that strives to provide these. It consists of two major concepts. A technology manageme

  17. Are safety data sheets for cleaning products used in Norway a factor contributing to the risk of workers exposure to chemicals?

    Directory of Open Access Journals (Sweden)

    Abdulqadir M. Suleiman

    2014-10-01

    Full Text Available Objectives: Cleaning products are considered less hazardous than those used in other sectors. Suppliers and distributors are less conscientious when it comes to informing users on health risks. The aim of the study was to elaborate on the usefulness and clarity of information in the safety data sheets (SDS for cleaning products, and considering if the use of these SDSs can be seen as a risk factor towards occupational exposure to hazardous chemicals in the sector. Material and Methods: Safety data sheets were selected based on the risk level of the product assigned in an industrial sector scheme. 320 SDSs for cleaning products were reviewed. Constituent components found in the products over a given threshold were listed and available information thereof used to assess the perceived non-hazard consideration of the chemicals. Results: The contents of the SDSs was generic and mostly incomplete. Safety measures and health information lacked sufficient specificity despite varying compositions and concentrations of components. There is generally incompatibility between mentioned sections on the suggested non-hazardous nature of the products and health effects. Not all substances used in these products have harmonized classifications, which makes them open to various classification of the products and the suggested safety measures. This results in different companies classifying similar products differently. Risk management measures and suggested personal protective equipment (PPEs are given haphazardly. Physical properties relevant to risk assessment are not included. Conclusions: The safety data sheets are ambiguous, and they lack relevant and important information. Inadequate information and risk assessment concerning the products can lead to workers being exposed to hazardous chemicals. Underestimation of the hazard contribution of the components of the products and the insufficient, non-objective mention of appropriate control and protective

  18. Industrial Measurement System Based on Distributed IPC%分布式IPC工业测控系统

    Institute of Scientific and Technical Information of China (English)

    谢辉; 陈曾汉

    2008-01-01

    针对目前工业测控需求,设计了一个分布式IPC(工业PC:industry personal computer)工业测控系统,并阐明了系统的设计思想、结构和实现的功能.该系统下位机选用IPC,并采用C语言编写的简化的多任务实时操作系统MROS(Multi-task Real-time Operating System)对多路模拟量、开关量进行采集、存储和控制,具有较高的实时性和可靠性.系统的上位机采用VB6.0编程,对其所管理的下位机运行参数进行定时采集、显示和报表打印,具有人机界面友好,功能强大等特点.上下位机通信系统设计选用抗干扰能力强大的RS-485网络标准以及智能通信控制器进行通信管理,并采取了一定的软硬件抗干扰措施,通信可靠,维护简单.实验证明,系统经济、实用,具有一定的推广应用价值.

  19. The 5th World Congress of chemical engineering: Technologies critical to a changing World. Volume II: Agriculture, food biotechnology biomedical electric power process safety

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    Volume 2 of the proceedings from the 5th World Congress of Chemical Engineering covers four major topic areas from which papers were selected for the database: Agriculture, Food; Biotechnology; Electric Power, and Process Safety. Pertinent subtopics include: Renewable Resource Engineering; Special Processes in the Food Industry; Advances in Metabolite Production; Advances in Fermentation and Cell Culture Engineering; Coal and Nuclear Central Station Power Plants; Large Natural Gas Fired Power Stations; Distributed Generation; Potential Impact of Biomass Energy; and Chemical Hazards in Plant Design. 29 papers were selected from Volume 1 for the database.

  20. Scientific Opinion on the safety and efficacy of the use of amino acids (chemical group 34 when used as flavourings for all animal species

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP

    2014-05-01

    Full Text Available Chemical group (CG 34 comprises amino acids, of which 20 are currently authorised for use as flavours in food. The FEEDAP Panel was unable to perform an assessment of D,L-valine because of the lack of data on its purity. The Panel cannot conclude on the use of these compounds in water for drinking. In the absence of any information on the microbial strains or substrates used for the production of the additives, and with little information on the manufacturing process, the Panel cannot ascertain whether the manufacturing process introduces any safety concerns. The conclusions on target animals and consumer safety apply only to the compounds per se, and can be extrapolated only to feed additives containing these compounds when obtained by chemical synthesis or protein hydrolysis and to those produced by fermentation which have already undergone a strain-specific safety assessment by EFSA. The 19 compounds under assessment in CG 34 are safe at the proposed use level of 25 mg/kg feed for all animal species. The FEEDAP Panel considers the use of glycine at 20 g/kg in food for cats and dogs as safe. The safety of the proposed use of beta-alanine in pet food at 20 g/kg was not substantiated. Use of these compounds does not give rise to concern for consumer safety. The Panel considers it prudent to treat all 19 compounds as irritant to skin and eyes, skin sensitisers and hazardous by inhalation. They do not give rise to any concern for the safety of the environment. No further demonstration of their efficacy is necessary when used at concentrations up to 25 mg/kg complete feed. There is some evidence that high concentrations (20 g/kg in cat and dog food of glycine may influence the food preference of cats and dogs. Comparable evidence for beta-alanine is not available.

  1. 间歇充气压力系统(IPC)在预防妇科围术期深静脉血栓(DVT)形成的作用

    Institute of Scientific and Technical Information of China (English)

    张红; 张芳

    2012-01-01

    目的 研讨间歇充气压力系统(IPC)在预防妇科围手术期下肢深静脉血栓(DVT)形成中的作用和护理.方法 将术后患者300例随机分为对照组和实验组,150例术后使用(IPC),150例未使用(IPC).结果 使用(IPC) DVT发生率低于未使用(IPC),P<0.05,差异有统计学意义.结论 IPC在妇科围手术期深静脉血栓(DVT)形成方面有预防作用.

  2. Lessons learned from process incident databases and the process safety incident database (PSID) approach sponsored by the Center for Chemical Process Safety

    Energy Technology Data Exchange (ETDEWEB)

    Sepeda, Adrian L. [American Institute of Chemical Engineers, Center for Chemical Process Safety, A.L. Sepeda Consulting Inc., P.O. Box 250183, Plano, TX 75025-0183 (United States)]. E-mail: Adrian_L@swbell.net

    2006-03-17

    Learning from the experiences of others has long been recognized as a valued and relatively painless process. In the world of process safety, this learning method is an essential tool since industry has neither the time and resources nor the willingness to experience an incident before taking corrective or preventative steps. This paper examines the need for and value of process safety incident databases that collect incidents of high learning value and structure them so that needed information can be easily and quickly extracted. It also explores how they might be used to prevent incidents by increasing awareness and by being a tool for conducting PHAs and incident investigations. The paper then discusses how the CCPS PSID meets those requirements, how PSID is structured and managed, and its attributes and features.

  3. Research on safety guarantee system for chemical industrial parks%化工园区安全保障体系探究

    Institute of Scientific and Technical Information of China (English)

    陈国华; 贾梅生; 黄庭枫

    2013-01-01

    This paper is inclined to introduce and synthesize some new ideas and research results about safety control and secure engineering technology in running chemical industrial parks.As is well known,chemical industrial parks involve more safety and security problems for their own particular nature.Yet,there is still shortage of a systematic framework and comprehensive measures to ensure their regular production practice.To meet the actual need,we would like to bring forward a set of safety production and management warranty including three strategies.The first one deals with a set of inherent safety-ensuring strategies through eliminating or getting rid of likely hazards to prevent likely accidents.In our suggested framework,the inherent safety strategy is supposed to include three key techniques,i.e.optimized layout of management goals,idealistic chain of their industrial products and safety and security controlling power.As a rule,the operating goals should be oriented to guide the stage of designing a new chemical industrial park or the stage of introducing a new chemical plant to a well managed chemical park so that the park is always in a position to keep on its successful production and implement the most effective measures for accident prevention.The second strategy of the framework is to make sure successful risk control with the so-called four key techniques thoroughly carried out,i.e.identifying and recognizing hidden hazards,analyzing and controlling Domino effect accidents,early-warning and always aware of community emergencies.The said risk control strategy should be oriented to decrease the accident frequency or alleviating the accident detrimental influence.PDCA is needed for this strategy to heighten the safety control rate of the chemical industrial parks.And,now,the last strategy is to establish necessary institutions and cuhivate safety culture.There exists a vast need for the chemical industrial parks to ask for the managers and workers to display

  4. 化工企业安全教育系统的设计与实现%Design and development of safety education system in chemical plant

    Institute of Scientific and Technical Information of China (English)

    张磊; 蔡智聪; 朱群雄

    2012-01-01

    Safety production is crucial in chemical plant. However, accidents in the production process are often closely related to unsafe behavior of human beings. So it is very important for staff to get the routine safety education. Based on the investigation of routine safety education in chemical plant, we have researched the informationization method in safety training of chemical plant, designed the safety education system and developed softwares to provide the ways of safety training, examination and management for staff. Combining with multimedia and virtual reality technology it enhanced the reality of education and increased users' participation. The system was developed on the basis of B/S framework, which used Microsoft .net and web technology to accomplish a three-tier scalable system. Meanwhile it also uses JavaScript to accomplish the interactive exam with the virtual reality scene in web pages. Currently the system has successfully run in a chemical corporation and become a part of department performance evaluation.%化工企业的安全生产是至关重要的,而生产过程中事故的发生往往和人的不安全行为紧密相关,因此对职工的日常安全教育工作格外重要.基于对化工企业日常安全教育工作的考察,研究了化工企业安全培训工作中的信息化方法,并设计开发了石化企业安全教育系统,提供面向职工的安全信息培训、考核、管理方法,结合多媒体、虚拟现实等技术提高了教育的真实感和参与度.该系统基于B/S模式开发,使用.net框架和各种Web技术完成了3层架构的可扩展系统,并利用JavaScript脚本实现了网页内的虚拟现实场景交互试题.目前该系统已在某化工企业成功运行,其使用已成为部门绩效考核的一部分.

  5. Chemical mechanical polishing of Indium phosphide, Gallium arsenide and Indium gallium arsenide films and related environment and safety aspects

    Science.gov (United States)

    Matovu, John Bogere

    As scaling continues with advanced technology nodes in the microelectronic industry to enhance device performance, the performance limits of the conventional substrate materials such as silicon as a channel material in the front-end-of-the-line of the complementary metal oxide semiconductor (CMOS) need to be surmounted. These challenges have invigorated research into new materials such as III-V materials consisting of InP, GaAs, InGaAs for n-channel CMOS and Ge for p-channels CMOS to enhance device performance. These III-V materials have higher electron mobility that is required for the n-channel while Ge has high hole mobility that is required for the p-channel. Integration of these materials in future devices requires chemical mechanical polishing (CMP) to achieve a smooth and planar surface to enable further processing. The CMP process of these materials has been associated with environment, health and safety (EH&S) issues due to the presence of P and As that can lead to the formation of toxic gaseous hydrides. The safe handling of As contaminated consumables and post-CMP slurry waste is essential. In this work, the chemical mechanical polishing of InP, GaAs and InGaAs films and the associated environment, health and safety (EH&S) issues are discussed. InP removal rates (RRs) and phosphine generation during the CMP of blanket InP films in hydrogen peroxide-based silica particle dispersions in the presence and absence of three different multifunctional chelating carboxylic acids, namely oxalic acid, tartaric acid, and citric acid are reported. The presence of these acids in the polishing slurry resulted in good InP removal rates (about 400 nm min-1) and very low phosphine generation (slurry compositions consisting of 3 wt % silica, 1 wt % hydrogen peroxide and 0.08 M oxalic acid or citric acid that provided the best results on blanket InP films were used to evaluate their planarization capability of patterned InP-STI structures of 200 mm diameter wafers. Cross

  6. An IPC-based Prolog design pattern for integrating backward chaining inference into applications or embedded systems

    Institute of Scientific and Technical Information of China (English)

    Li Guoqi; Shao Yuanxun; Hong Sheng; Liu Bin

    2014-01-01

    Prolog is one of the most important candidates to build expert systems and AI-related programs and has potential applications in embedded systems. However, Prolog is not suitable to develop many kinds of components, such as data acquisition and task scheduling, which are also crucial. To make the best use of the advantages and bypass the disadvantages, it is attractive to inte-grate Prolog with programs developed by other languages. In this paper, an IPC-based method is used to integrate backward chaining inference implemented by Prolog into applications or embed-ded systems. A Prolog design pattern is derived from the method for reuse, whose principle and def-inition are provided in detail. Additionally, the design pattern is applied to a target system, which is free software, to verify its feasibility. The detailed implementation of the application is given to clar-ify the design pattern. The design pattern can be further applied to wide range applications and embedded systems and the method described in this paper can also be adopted for other logic pro-gramming languages.

  7. ¿Han sido el IBEX35 y el IPC definiciones financieramente eficientes del portafolio de mercado?

    Directory of Open Access Journals (Sweden)

    Óscar Valdemar de la Torre Torres

    2013-01-01

    Full Text Available En este trabajo se presenta un estudio inicial que cuestiona la eficiencia financiera de las aproximaciones del portafolio de mercado más empleadas en España y México (IBEX35 e IPC; se observa que podrían no considerarse como tales, con lo que se pone en duda su uso como “referencias neutrales”, según lo proponen Black y Litterman (1992, para la gestión de los mismos. Con el objeto de probar la eficiencia financiera en estos dos índices, se desarrollaron dos simulaciones de eventos discretos empleando el modelo Markowitz-Tobin-Sharpe-Lintner (Markowitz, 1987 con datos de frecuencia mensual -a partir de febrero de 2001 a diciembre de 2010- de sus acciones miembro en una ventana temporal. Los resultados fueron comparados a través del ratio de Sharpe (1966 y demostraron que, en el corto plazo, los supuestos de equilibrio no se mantienen y las aproximaciones del portafolio de mercado estudiadas resultan ineficientes en relación con otros portafolios óptimos derivados de manera simultánea.

  8. Reconciling the IPC and Two-Hit Models: Dissecting the Underlying Cellular and Molecular Mechanisms of Two Seemingly Opposing Frameworks.

    Science.gov (United States)

    Morris, Carlos F M; Tahir, Muhammad; Arshid, Samina; Castro, Mariana S; Fontes, Wagner

    2015-01-01

    Inflammatory cascades and mechanisms are ubiquitous during host responses to various types of insult. Biological models and interventional strategies have been devised as an effort to better understand and modulate inflammation-driven injuries. Amongst those the two-hit model stands as a plausible and intuitive framework that explains some of the most frequent clinical outcomes seen in injuries like trauma and sepsis. This model states that a first hit serves as a priming event upon which sequential insults can build on, culminating on maladaptive inflammatory responses. On a different front, ischemic preconditioning (IPC) has risen to light as a readily applicable tool for modulating the inflammatory response to ischemia and reperfusion. The idea is that mild ischemic insults, either remote or local, can cause organs and tissues to be more resilient to further ischemic insults. This seemingly contradictory role that the two models attribute to a first inflammatory hit, as priming in the former and protective in the latter, has set these two theories on opposing corners of the literature. The present review tries to reconcile both models by showing that, rather than debunking each other, each framework offers unique insights in understanding and modulating inflammation-related injuries.

  9. An IPC-based Prolog design pattern for integrating backward chaining inference into applications or embedded systems

    Directory of Open Access Journals (Sweden)

    Li Guoqi

    2014-12-01

    Full Text Available Prolog is one of the most important candidates to build expert systems and AI-related programs and has potential applications in embedded systems. However, Prolog is not suitable to develop many kinds of components, such as data acquisition and task scheduling, which are also crucial. To make the best use of the advantages and bypass the disadvantages, it is attractive to integrate Prolog with programs developed by other languages. In this paper, an IPC-based method is used to integrate backward chaining inference implemented by Prolog into applications or embedded systems. A Prolog design pattern is derived from the method for reuse, whose principle and definition are provided in detail. Additionally, the design pattern is applied to a target system, which is free software, to verify its feasibility. The detailed implementation of the application is given to clarify the design pattern. The design pattern can be further applied to wide range applications and embedded systems and the method described in this paper can also be adopted for other logic programming languages.

  10. 化工行业“安全观察与沟通”的初步探索%Safety Observation and Communication Exploration on Chemical Industry

    Institute of Scientific and Technical Information of China (English)

    赵林; 王述存; 孟力

    2016-01-01

    安全观察与沟通是落实有感领导、展现领导承诺的一种有效手段[1]。通过对杜邦公司安全文化体系的认知,深刻剖析在化工危险作业中应该如何做好安全观察与沟通。结合当前在化工生产中的重点应用及注意事项,本文分别对安全观察与沟通的概况、内容及应用等,进行了较详细的分析与阐述。在工作中倡导并积极开展安全观察与沟通,将达到较好的安全管理效果。%Security Watch is to implement felt leadership and communication, as a means to show leadership commitments. Through the perception of the state company's safety culture system, a profound analysis of the chemical industry should be how to do dangerous work safety observation and communication. Combined with the current focus on the application and precautions in chemical production, the significance of safety observation and communication, content and applications were carried on for a more detailed exposition and analysis. Advocacy at work and actively carrying out safety observation and communication will achieve better security management effectiveness.

  11. Review of the state of the art of human biomonitoring for chemical substances and its application to human exposure assessment for food safety

    DEFF Research Database (Denmark)

    Choi, Judy; Mørck, Thit Aarøe; Polcher, Alexandra

    2015-01-01

    Human biomonitoring (HBM) measures the levels of substances in body fluids and tissues. Many countries have conducted HBM studies, yet little is known about its application towards chemical risk assessment, particularly in relation to food safety. Therefore a literature search was performed in se......, expanded monitoring of highly exposed and vulnerable subgroups, uptake of EFSA guidance concerning dietary intake assessment, as well as biobanking, surveillance synergies and targeted research, and an EU wide collaborative approach to support the future use of HBM in PMM....

  12. Chemical research projects office functions accomplishments programs. [applied research in the fields of polymer chemistry and polymeric composites with emphasis on fire safety

    Science.gov (United States)

    Heimbuch, A. H.; Parker, J. A.

    1975-01-01

    Basic and applied research in the fields of polymer chemistry, polymeric composites, chemical engineering, and biophysical chemistry is summarized. Emphasis is placed on fire safety and human survivability as they relate to commercial and military aircraft, high-rise buildings, mines and rapid transit transportation. Materials systems and other fire control systems developed for aerospace applications and applied to national domestic needs are described along with bench-scale and full-scale tests conducted to demonstrate the improvements in performance obtained through the utilization of these materials and fire control measures.

  13. Analysis of chemical process safety based on data dependence%基于数据依赖关系的化工过程安全分析

    Institute of Scientific and Technical Information of China (English)

    史晟辉; 朱群雄; 耿志强

    2012-01-01

    针对化工过程间安全分析问题,结合计算机领域中数据依赖技术,提出一种新的应用于化工过程的安全分析解决方案.以双容水槽液位控制系统为实例,分析工艺流程和变量之间的关系,从中提取9个状态,10个迁移过程以及迁移的条件、事件及执行过程等信息,建立其扩展有限状态机模型.通过考察迁移T8中L2变量,分析其数据依赖关系路径,确定数据依赖正负影响关系,实现基于数据依赖的化工过程安全分析新方法,并通过对T4中L2变量的分析验证了所提方法的有效性,使得扩展有限状态机数据依赖技术成为计算机自动推理来实现化工过程的安全分析的一种新的有效方法.%For chemical process safety analysis, data dependencies method in the computer field is made Use of, and a new used in chemical process safety analysis solution is present. Token double water tank level control system as an example, the relationship between the process and the variables is analyzed, and nine states, ten transitions in which including the conditions, events and actions are extracted. Based on the above extended finite state machine model is established. Moreover, in order to get the factors affecting the result of variables L2 in 7g, related data dependency paths and positive and negative relations affecting L2 are analyzed. Then new method of chemical process safety analysis based on the data-dependent is achieved, and the validity of the proposed method is testified by analyzing of variables 12 in the Tt. Data dependency technology based on extended finite state machine becomes an effective method which applying computer automated reasoning to achieve safety analysis in chemical process.

  14. Daily scale wintertime sea surface temperature and IPC-Navidad variability in the southern Bay of Biscay from 1981 to 2010

    Science.gov (United States)

    Esnaola, G.; Sáenz, J.; Zorita, E.; Fontán, A.; Valencia, V.; Lazure, P.

    2013-07-01

    The combination of remotely sensed gappy Sea surface temperature (SST) images with the missing data filling DINEOF (data interpolating empirical orthogonal functions) technique, followed by a principal component analysis of the reconstructed data, has been used to identify the time evolution and the daily scale variability of the wintertime surface signal of the Iberian Poleward Current (IPC), or Navidad, during the 1981-2010 period. An exhaustive comparison with the existing bibliography, and the vertical temperature and salinity profiles related to its extremes over the Bay of Biscay area, show that the obtained time series accurately reflect the IPC-Navidad variability. Once a time series for the evolution of the SST signal of the current over the last decades is well established, this time series is used to propose a physical mechanism in relation to the variability of the IPC-Navidad, involving both atmospheric and oceanic variables. According to the proposed mechanism, an atmospheric circulation anomaly observed in both the 500 hPa and the surface levels generates atmospheric surface level pressure, wind-stress and heat-flux anomalies. In turn, those surface level atmospheric anomalies induce mutually coherent SST and sea level anomalies over the North Atlantic area, and locally, in the Bay of Biscay area. These anomalies, both locally over the Bay of Biscay area and over the North Atlantic, are in agreement with several mechanisms that have separately been related to the variability of the IPC-Navidad, i.e. the south-westerly winds, the joint effect of baroclinicity and relief (JEBAR) effect, the topographic β effect and a weakened North Atlantic gyre.

  15. Daily scale wintertime sea surface temperature and IPC-Navidad variability in the southern Bay of Biscay from 1981 to 2010

    Directory of Open Access Journals (Sweden)

    G. Esnaola

    2013-07-01

    Full Text Available The combination of remotely sensed gappy Sea surface temperature (SST images with the missing data filling DINEOF (data interpolating empirical orthogonal functions technique, followed by a principal component analysis of the reconstructed data, has been used to identify the time evolution and the daily scale variability of the wintertime surface signal of the Iberian Poleward Current (IPC, or Navidad, during the 1981–2010 period. An exhaustive comparison with the existing bibliography, and the vertical temperature and salinity profiles related to its extremes over the Bay of Biscay area, show that the obtained time series accurately reflect the IPC-Navidad variability. Once a time series for the evolution of the SST signal of the current over the last decades is well established, this time series is used to propose a physical mechanism in relation to the variability of the IPC-Navidad, involving both atmospheric and oceanic variables. According to the proposed mechanism, an atmospheric circulation anomaly observed in both the 500 hPa and the surface levels generates atmospheric surface level pressure, wind-stress and heat-flux anomalies. In turn, those surface level atmospheric anomalies induce mutually coherent SST and sea level anomalies over the North Atlantic area, and locally, in the Bay of Biscay area. These anomalies, both locally over the Bay of Biscay area and over the North Atlantic, are in agreement with several mechanisms that have separately been related to the variability of the IPC-Navidad, i.e. the south-westerly winds, the joint effect of baroclinicity and relief (JEBAR effect, the topographic β effect and a weakened North Atlantic gyre.

  16. SAFETY INSTRUCTION AND SAFETY NOTE

    CERN Multimedia

    TIS Secretariat

    2002-01-01

    Please note that the SAFETY INSTRUCTION N0 49 (IS 49) and the SAFETY NOTE N0 28 (NS 28) entitled respectively 'AVOIDING CHEMICAL POLLUTION OF WATER' and 'CERN EXHIBITIONS - FIRE PRECAUTIONS' are available on the web at the following urls: http://edms.cern.ch/document/335814 and http://edms.cern.ch/document/335861 Paper copies can also be obtained from the TIS Divisional Secretariat, email: TIS.Secretariat@cern.ch

  17. Chemical analysis of estragole in fennel based teas and associated safety assessment using the Margin of Exposure (MOE) approach

    NARCIS (Netherlands)

    Berg, van den S.J.P.L.; Alhusainy, W.; Restani, P.; Rietjens, I.

    2014-01-01

    This study describes the analysis of estragole in dry fennel preparations and in infusions prepared from them and an associated safety assessment. A wide range of estragole levels of 0.15–13.3 mg/g dry fennel preparation was found. The estragole content in infusions was considerably lower ranging be

  18. One Method to Realize Built-in PLC Based on IPC%一种基于 IPC的内嵌式PLC的实现方法

    Institute of Scientific and Technical Information of China (English)

    李左章; 周云飞; 胡建中

    2000-01-01

    One method of realizing built-in PLC based on IPC (Industrial Personal Computer)is given in this paper, this method is suitable for CNC system with one CPU, and can make the structure of CNC compact. The PLC system realized by this method is capable of PLC command editing, compiling, and executing, besides this, both terminal signals and ladder diagram is provided with the help of rich software resource of IPC,these two are convenient in CNC system debugging stage. This method is a universal method and is easy to be realized. This method has been applied in CNC system of our institute.%给出一种实用的,基于IPC(工业PC)的内嵌式PLC系统实现方法。该方法具有易于实现,通用性好,独立性强等优点,尤其适合于单机,单CPU的CNC系统使用。用该方法开发的PLC系统,除了具有PLC指令编辑,编译,执行等功能,还具有PLC端子状态和梯形图显示等有利于CNC系统调试的功能。系统经实际应用,效果良好。

  19. IPC-T-50电子电路互连与封装术语及定义(二)

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    为了让广大行业人士更好的了解行业的基本术语的中英文对比与对照,促进SMT行业技术交流与标准化进程,本刊将连载IPC—T-50术语与定义手册的相关内容,供广大行业人士参考!并希望得到广大行业人士长期的支持,欢迎广大行业人士向我刊投稿或提出宝贵意见。本文由IPC术语及定义委员会(2—30)开发,由IPC TGAsia2-30CN委员会翻译,由IPC TGAsia2-30CN委员会成员/IPC CIT讲师康来辉提供,最终解释权为IPC协会。

  20. 相间功率控制器改善暂态稳定性的研究%Analysis of enhancing transient stability of power system with IPC

    Institute of Scientific and Technical Information of China (English)

    李娟; 郑明

    2011-01-01

    相间功率控制器(Interphase Power Controller,IPC)接入互联系统中对稳定性有一定的影响.基于IPC元件参数与功率之间的关系,通过简单系统的功角曲线分析了调节IPC元件参数改善系统暂态稳定性的机理.基于IPC的端口电压与电流的关系,说明IPC是电压控制的电流源,据此设计了功率和电流双回路可控相间功率控制器(Thyristor Controlled Interphase Power Controller,TCIPC)的控制系统.以电流作为TCIPC晶闸管的同步信号,将线路电流和有功功率的期望值作为IPC控制器的参考信号,设计了不完全微分PID控制模型.仿真结果表明:在系统发生扰动的情况下,通过设计的控制器能较好地调节TCIPC电感参数,从而有效地控制联络线的传输功率,改善带TCIPC互联系统的暂态稳定性.%The connection of the Interphase Power Controller (IPC) to the power system affects its stability. Based on the relationship between the elements of IPC and power flow, and via the angle curve of simple power system, the principle of improving the transient stability by regulating the parameters of IPC is analyzed. The equation about the voltage and current indicates that IPC is a voltage dependent current source. A control system of Thyristor Controlled Interphase Power Controller (TCIPC) with double loop is designed. Taking the current as the sync signal, the expected value of power and current as reference signals, an incomplete differential PID control model is established. The results of simulation demonstrate that the controller can regulate the impedance of TCIPC when the disturbance occurs, which guarantees the power of transmission line in the transient course, then improves the transient stability of the power system.

  1. An in vitro method for detecting chemical sensitization using human reconstructed skin models and its applicability to cosmetic, pharmaceutical, and medical device safety testing.

    Science.gov (United States)

    McKim, James M; Keller, Donald J; Gorski, Joel R

    2012-12-01

    Chemical sensitization is a serious condition caused by small reactive molecules and is characterized by a delayed type hypersensitivity known as allergic contact dermatitis (ACD). Contact with these molecules via dermal exposure represent a significant concern for chemical manufacturers. Recent legislation in the EU has created the need to develop non-animal alternative methods for many routine safety studies including sensitization. Although most of the alternative research has focused on pure chemicals that possess reasonable solubility properties, it is important for any successful in vitro method to have the ability to test compounds with low aqueous solubility. This is especially true for the medical device industry where device extracts must be prepared in both polar and non-polar vehicles in order to evaluate chemical sensitization. The aim of this research was to demonstrate the functionality and applicability of the human reconstituted skin models (MatTek Epiderm(®) and SkinEthic RHE) as a test system for the evaluation of chemical sensitization and its potential use for medical device testing. In addition, the development of the human 3D skin model should allow the in vitro sensitization assay to be used for finished product testing in the personal care, cosmetics, and pharmaceutical industries. This approach combines solubility, chemical reactivity, cytotoxicity, and activation of the Nrf2/ARE expression pathway to identify and categorize chemical sensitizers. Known chemical sensitizers representing extreme/strong-, moderate-, weak-, and non-sensitizing potency categories were first evaluated in the skin models at six exposure concentrations ranging from 0.1 to 2500 µM for 24 h. The expression of eight Nrf2/ARE, one AhR/XRE and two Nrf1/MRE controlled gene were measured by qRT-PCR. The fold-induction at each exposure concentration was combined with reactivity and cytotoxicity data to determine the sensitization potential. The results demonstrated that

  2. Chemical Products in the Home, Workshop and Garden. Proceed with Caution; Consumer Safety in the Home, II.

    Science.gov (United States)

    Saskatchewan Consumer and Commercial Affairs, Regina.

    The average home has chemical products to clean floors, kill insects, clean ovens, thin paint, remove grease, and perform countless other chores. Many consumers remain unaware of the dangers these products bring into the home. This booklet provides information on the safe use, storage, and disposal of these products. The compounds found in…

  3. Testing REACH draft technical guidance notes for conducting chemical safety assessments-the experience of a downstream user of a preparation.

    Science.gov (United States)

    Gade, Anne Lill; Ovrebø, Steinar; Hylland, Ketil

    2008-07-01

    The goal of REACH is the safe use of chemicals. This study examines the efficiency and usefulness of two draft technical guidance notes in the REACH Interim Project 3.2-2 for the development of the chemical safety report and exposure scenarios. A case study was carried out for a paint system for protection of structural steel. The focuses of the study were risk assessment of preparations based on Derived No Effect Level (DNEL) and Predicted No Effect Concentrations (PNEC) and on effective and accurate communication in the supply chain. Exposure scenarios and generic descriptions of uses, risk management measures, and exposure determinants were developed. The study showed that communication formats, software tools, and guidelines for chemical risk assessment need further adjustment to preparations and real-life situations. Web platforms may simplify such communication. The downstream formulator needs basic substance data from the substance manufacturer during the pre-registration phase to develop exposure scenarios for preparations. Default values need to be communicated in the supply chain because these were critical for the derivation of applicable risk management demands. The current guidelines which rely on the available toxicological knowledge are insufficient to advise downstream users on how to develop exposure scenarios for preparations.

  4. To investigate the testing institution of safety management of hazardous chemicals%检测机构危险化学品安全管理探讨

    Institute of Scientific and Technical Information of China (English)

    任广涛

    2015-01-01

    近年来检测市场日渐繁荣,危险化学品管理这一检测机构内部的安全隐患也开始凸显.本文分析了检测机构在危险化学品管理中存在的一些问题,并根据日常工作经验提出了健全规章制度、贯彻安全教育、完善健康监护和加强日常管理等建议,促进检测机构健康、稳定的往前发展.%With the increase in the number of domestic testing institution in recent years, the detection of the market's prosperity, hazardous chemicals management of the internal security risks have become increasingly prominent. This paper analyzes some problems in the management of hazardous chemicals, and puts forward some suggestions, such as improving rules and regulations, implementing safety education, improving health monitoring and strengthening daily management.In order to remove hazardous chemicals procurement, transportation, storage, use and disposal of the whole process of the security risks, so that testing institution can health and stable development.

  5. A quantitative screening-level approach to incorporate chemical exposure and risk/safety into alternative assessment evaluations.

    Science.gov (United States)

    Arnold, Scott M; Greggs, Bill; Goyak, Katy O; Landenberger, Bryce D; Mason, Ann M; Howard, Brett; Zaleski, Rosemary; Howard, Brett; Zaleski, Rosemary T

    2017-03-10

    As the general public and retailers ask for disclosure of chemical ingredients in the marketplace, a number of hazard screening tools were developed to evaluate the so called "greenness" of individual chemical ingredients and/or formulations. The majority of these tools focus only on hazard, often using chemical lists, ignoring the other part of the risk equation: exposure. Using a hazard-only focus can result in regrettable substitutions, changing one chemical ingredient for another that turns out to be more hazardous or shifts the toxicity burden to others. To minimize the incidents of regrettable substitutions, BizNGO describes 'Common Principles' to frame a process for informed substitution. Two of the six principles state reduce hazard and minimize exposure. A number of frameworks have emerged to evaluate and assess alternatives. One framework developed by leading experts under the auspices of the U.S. National Academy of Sciences recommended that hazard and exposure be specifically addressed in the same step when assessing candidate alternatives. For the alternative assessment community, this paper serves as an informational resource for considering exposure in an alternatives assessment using elements of problem formulation; product identity, use, and composition; hazard analysis; exposure analysis; and risk characterization. These conceptual elements build upon practices from government, academia, and industry and are exemplified through two hypothetical case studies demonstrating the questions asked and decisions faced in new product development. These two case studies - inhalation exposure to a generic paint product and environmental exposure to a shampoo rinsed down the drain - demonstrate the criteria, considerations, and methods required to combine exposure models addressing human health and environmental impacts to provide a screening level hazard/exposure (risk) analysis. This paper informs practices for these elements within a comparative risk

  6. A Five-year Follow-up Study on the Efficacy and Safety of Female Tubal Sterilization by Chemical Instillation

    Institute of Scientific and Technical Information of China (English)

    刘云嵘; 吴裕浩; 陈学煌; 黄真嘉; 徐铎; 蔡光宗

    1999-01-01

    A multi-center randomized clinical trial was adopted in the present study. 1705 eligible women with identical demographic and gynecological characteristics were divided into two groups: 871 using phenol-atabrine paste (PAP) and 834 using phenol mucilage (PM). The five-year follow-up rates for the two groups were 97. 5% and 98. 1%, respectively. The multiple decrement life table analysis showed that there was a significant difference in the gross cumulative failure rates between the two groups,The 60th month gross cumulative failure rates for PAP group and PM group were 4. 61% and 11. 87%, respectively, thus indicating the efficacy of PAP to be significantly higher than that of PM. 97. 7% users had cervical smear examinations, but no suspected cancer cells or cancer cells were found. Meanwhile, there was no known diseases related to the chemical reagent. This follow-up study indicates that tubal sterilization by chemical instillation is a simple,safe and efficient female method. It suggested that this method would be introduced to a wider use on the basis of modification in the composition of chemical agents, standardized operational procedure, and improved administrative regulation in the use of this technology.

  7. [Alternative methods to animal experiments. What can they afford in the safety testing of chemical substances under REACH?].

    Science.gov (United States)

    Lilienblum, Werner

    2008-12-01

    Alternative methods to safety studies using laboratory animals have been accepted by the OECD in areas such as local toxicity and mutagenicity. In more complex important fields, such as systemic single and repeated dose toxicity, toxicokinetics, sensitisation, reproductive toxicity and carcinogenicity, it is expected that the development and validation of computerised methods, testing batteries (in vitro and in silico) and tiered testing systems will need many years and have to overcome many scientific and regulatory obstacles, which makes it extremely difficult to predict the outcome and the time needed. Therefore, the validated alternative methods available will only have a limited impact on reducing the numbers of animals required under REACH. In the midterm, the strategy should be more directed towards the refinement or reduction of in vivo testing because the replacement concerning complex toxicological endpoints is at present not in sight.

  8. An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy.

    Science.gov (United States)

    Brownbill, Paul; Chernyavsky, Igor; Bottalico, Barbara; Desoye, Gernot; Hansson, Stefan; Kenna, Gerry; Knudsen, Lisbeth E; Markert, Udo R; Powles-Glover, Nicola; Schneider, Henning; Leach, Lopa

    2016-09-01

    The human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; a unique organ, species specific in structure and function. We consider the pressing challenge of providing additional advice on the safety of prescription medicines and environmental exposures in pregnancy and how ex vivo and in vitro human placental models might be advanced to reproducible human placental test systems (HPTSs), refining a weight of evidence to the guidance given around compound risk assessment during pregnancy. The placental pharmacokinetics of xenobiotic transfer, dysregulated placental function in pregnancy-related pathologies and influx/efflux transporter polymorphisms are a few caveats that could be addressed by HPTSs, not the specific focus of current mammalian reproductive toxicology systems. An international consortium, "PlaNet", will bridge academia, industry and regulators to consider screen ability and standardisation issues surrounding these models, with proven reproducibility for introduction into industrial and clinical practice. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Description for Hazard Forecasting Training and Safety Confirmation in Chemical Production Site%谈化工生产现场的危险预知和安全确认过程

    Institute of Scientific and Technical Information of China (English)

    何龙; 詹志勇; 王会兵; 张远东

    2011-01-01

    化工生产现场的安全行动要从提高安全意识开始.做到危险预知和虚惊一场报告;为了养成良好操作习惯,还要实践指差呼称,体现化工安全操作原则“确认-操作-再确认”,承诺自己的安全自己来维护。%To involve the safety action in chemical production site: firstly, in order to foster safety awareness, to carry out hazard forecasting training and near miss report. Secondly, in order to cultivate good habit, to fulfill "point & call", to reflect the chemical safety operation principal " confirmation - operation - confirmation". Finally, should promise that we must be responsible for our own safety.

  10. Safety of chemical processes, basic knowledge and risk analysis methods; Securite des procedes chimiques, connaissances de base et methodes d'analyse de risques

    Energy Technology Data Exchange (ETDEWEB)

    Laurent, A. [Ecole Nationale des Industries Chimiques, Institut Poytechnique de Lorraine, 54 - Nancy (France)

    2003-05-01

    The evaluation of the risks linked with an industrial facility involves two complementary approaches: the risk analysis and the evaluation of the potential consequences. This book presents a balanced compromise between these two approaches where the basic knowledge aspects and the methodologies are tightly imbricated. After a short presentation of safety terminology and of some hazard indicators and their perception, the book reviews the basic knowledge and the main methods of risk analysis to be considered in the design, development, exploitation and maintenance of a chemical process: 1 - general considerations about processes safety; 2 - the hazard process; 3 - the emission flow rate and the pre-dimensioning of vents; 4 - elements of atmospheric dispersion; 5 - combustions-explosions and gas and vapor fires; 6 - dust explosions; 7 - thermal burst; 8 - domino effect; 9 - static electricity risk in processes; 10 - general overview of risk analysis methods; 11 - preliminary risk analysis (PRA); 12 - Hazop (hazard and operability studies) method; event tree methods; MOSAR method (systemic organised method of risk analysis); 15 - risk mastery approach. (J.S.)

  11. Pronóstico del rendimiento del IPC (Índice de Precios y Cotizaciones mediante el uso de redes neuronales diferenciales

    Directory of Open Access Journals (Sweden)

    Agustín Ignacio Cabrera Llanos

    2012-01-01

    Full Text Available A través de los años, el uso de las redes neuronales artificiales como herramienta de simulación, modelación y descripción de sistemas dinámicos no lineales se ha ido consolidando como una técnica eficaz y relativamente rápida gracias al gran desarrollo experimentado en los sistemas de cómputo. Esta técnica de uso común en algunas áreas de la ingeniería aplicada se empezó a utilizar en aplicaciones financieras a mediados de la década de los noventa. El presente trabajo utiliza una de las técnicas más recientes y poderosas en este ámbito: las redes neuronales diferenciales (RND, usada frecuentemente en análisis de procesos de la biotecnología. Mediante esta técnica se lleva a cabo el análisis y la estimación de la evolución del comportamiento del rendimiento del IPC de la Bolsa Mexicana de Valores (BMV durante el periodo comprendido del 8 de noviembre de 1991 al 27 de enero de 2011. Adicionalmente, el análisis incluye un pronóstico intradía (seis valores durante una jornada de operación de la BMV del rendimiento del IPC, el cual tiene una duración de un día después del último dato de la serie de tiempo del IPC. Cabe señalar que los resultados pronosticados mostraron una gran similitud con los datos reales.

  12. Chemical, mechanical and antibacterial properties of silver nanocluster/silica composite coated textiles for safety systems and aerospace applications

    Energy Technology Data Exchange (ETDEWEB)

    Ferraris, S., E-mail: sara.ferraris@polito.it [Politecnico di Torino, Torino, C.so Duca degli Abruzzi 24, 10129 (Italy); Perero, S.; Miola, M.; Vernè, E. [Politecnico di Torino, Torino, C.so Duca degli Abruzzi 24, 10129 (Italy); Rosiello, A.; Ferrazzo, V.; Valletta, G. [Aero Sekur S.p.A., Aprilia, via delle Valli 46, 04011 (Italy); Sanchez, J.; Ohrlander, M. [Bactiguard AB, Biblioteksgatan 25, Box 5070, SE-10242, Stockholm (Sweden); Tjörnhammar, S.; Fokine, M.; Laurell, F. [KTH Royal Institute of Technology, Department of Applied Physics, Roslagstullsbacken 21, SE-106 91 Laserphysics, Stockholm (Sweden); Blomberg, E. [KTH Royal Institute of Technology, Div. Surface and Corrosion Science, Drottning Kristinas väg 51, SE-100 44, Stockholm (Sweden); SP Technical Research Institute of Sweden, Chemistry, Materials and Surfaces, Box 5607, SE-114 86, Stockholm (Sweden); Skoglund, S.; Odnevall Wallinder, I. [KTH Royal Institute of Technology, Div. Surface and Corrosion Science, Drottning Kristinas väg 51, SE-100 44, Stockholm (Sweden); Ferraris, M. [Politecnico di Torino, Torino, C.so Duca degli Abruzzi 24, 10129 (Italy)

    2014-10-30

    Highlights: • Silver nanoclusters-silica composite coatings were deposited on textiles. • Textiles for NBC protection suites and for aerospace applications were considered. • The coating process conferred all textiles a good antibacterial activity. • The coating does not alter the properties of bare textiles. - Abstract: This work describes the chemical, mechanical and antibacterial properties of a novel silver nanocluster/silica composite coating, obtained by sputtering, on textiles for use in nuclear bacteriological and chemical (NBC) protection suites and for aerospace applications. The properties of the coated textiles were analyzed in terms of surface morphology, silver concentration and silver release in artificial sweat and synthetic tap water, respectively. No release of silver nanoparticles was observed at given conditions. The water repellency, permeability, flammability and mechanical resistance of the textiles before and after sputtering demonstrated that the textile properties were not negatively affected by the coating. The antibacterial effect was evaluated at different experimental conditions using a standard bacterial strain of Staphylococcus aureus and compared with the behavior of uncoated textiles. The coating process conferred all textiles a good antibacterial activity. Optimal deposition conditions were elaborated to obtain sufficient antibacterial action without altering the aesthetical appearance of the textiles. The antibacterial coating retained its antibacterial activity after one cycle in a washing machine only for the Nylon based textile.

  13. A Review of Botanical Characteristics, Traditional Usage, Chemical Components, Pharmacological Activities, and Safety of Pereskia bleo (Kunth) DC.

    Science.gov (United States)

    Zareisedehizadeh, Sogand; Tan, Chay-Hoon; Koh, Hwee-Ling

    2014-01-01

    Pereskia bleo, a leafy cactus, is a medicinal plant native to West and South America and distributed in tropical and subtropical areas. It is traditionally used as a dietary vegetable, barrier hedge, water purifier, and insect repellant and for maintaining health, detoxification, prevention of cancer, and/or treatment of cancer, hypertension, diabetes, stomach ache, muscle pain, and inflammatory diseases such as dermatitis and rheumatism. The aim of this paper was to provide an up-to-date and comprehensive review of the botanical characteristics, traditional usage, phytochemistry, pharmacological activities, and safety of P. bleo. A literature search using MEDLINE (via PubMed), Science direct, Scopus and Google scholar and China Academic Journals Full-Text Database (CNKI) and available eBooks and books in the National University of Singapore libraries in English and Chinese was conducted. The following keywords were used: Pereskia bleo, Pereskia panamensis, Pereskia corrugata, Rhodocacus corrugatus, Rhodocacus bleo, Cactus panamensis, Cactus bleo, Spinach cactus, wax rose, Perescia, and Chinese rose. This review revealed the association between the traditional usage of P. bleo and reported pharmacological properties in the literature. Further investigation on the pharmacological properties and phytoconstituents of P. bleo is warranted to further exploit its potentials as a source of novel therapeutic agents or lead compounds.

  14. A Review of Botanical Characteristics, Traditional Usage, Chemical Components, Pharmacological Activities, and Safety of Pereskia bleo (Kunth DC

    Directory of Open Access Journals (Sweden)

    Sogand Zareisedehizadeh

    2014-01-01

    Full Text Available Pereskia bleo, a leafy cactus, is a medicinal plant native to West and South America and distributed in tropical and subtropical areas. It is traditionally used as a dietary vegetable, barrier hedge, water purifier, and insect repellant and for maintaining health, detoxification, prevention of cancer, and/or treatment of cancer, hypertension, diabetes, stomach ache, muscle pain, and inflammatory diseases such as dermatitis and rheumatism. The aim of this paper was to provide an up-to-date and comprehensive review of the botanical characteristics, traditional usage, phytochemistry, pharmacological activities, and safety of P. bleo. A literature search using MEDLINE (via PubMed, Science direct, Scopus and Google scholar and China Academic Journals Full-Text Database (CNKI and available eBooks and books in the National University of Singapore libraries in English and Chinese was conducted. The following keywords were used: Pereskia bleo, Pereskia panamensis, Pereskia corrugata, Rhodocacus corrugatus, Rhodocacus bleo, Cactus panamensis, Cactus bleo, Spinach cactus, wax rose, Perescia, and Chinese rose. This review revealed the association between the traditional usage of P. bleo and reported pharmacological properties in the literature. Further investigation on the pharmacological properties and phytoconstituents of P. bleo is warranted to further exploit its potentials as a source of novel therapeutic agents or lead compounds.

  15. In situ solid-state NMR and XRD studies of the ADOR process and the unusual structure of zeolite IPC-6

    Science.gov (United States)

    Morris, Samuel A.; Bignami, Giulia P. M.; Tian, Yuyang; Navarro, Marta; Firth, Daniel S.; Čejka, Jiří; Wheatley, Paul S.; Dawson, Daniel M.; Slawinski, Wojciech A.; Wragg, David S.; Morris, Russell E.; Ashbrook, Sharon E.

    2017-10-01

    The assembly-disassembly-organization-reassembly (ADOR) mechanism is a recent method for preparing inorganic framework materials and, in particular, zeolites. This flexible approach has enabled the synthesis of isoreticular families of zeolites with unprecedented continuous control over porosity, and the design and preparation of materials that would have been difficult—or even impossible—to obtain using traditional hydrothermal techniques. Applying the ADOR process to a parent zeolite with the UTL framework topology, for example, has led to six previously unknown zeolites (named IPC-n, where n = 2, 4, 6, 7, 9 and 10). To realize the full potential of the ADOR method, however, a further understanding of the complex mechanism at play is needed. Here, we probe the disassembly, organization and reassembly steps of the ADOR process through a combination of in situ solid-state NMR spectroscopy and powder X-ray diffraction experiments. We further use the insight gained to explain the formation of the unusual structure of zeolite IPC-6.

  16. Ion-pair chromatography coupled to inductively coupled plasma-mass spectrometry (IPC-ICP-MS) as a method for thiomolybdate speciation in natural waters.

    Science.gov (United States)

    Lohmayer, Regina; Reithmaier, Gloria Maria Susanne; Bura-Nakić, Elvira; Planer-Friedrich, Britta

    2015-03-17

    Molybdenum precipitates preferentially under reducing conditions; therefore, its occurrence in sediment records is used as an indicator of paleoredox conditions. Although thiomolybdates (MoO4-xSx(2-) with x = 1-4) supposedly are necessary intermediates in the process of molybdenum precipitation under anoxic conditions, there is no information about their abundance in natural environments, because of a lack of element-specific methods with sufficiently low detection limits. Here, we optimized ion-pair chromatographic separation for coupling to an inductively coupled plasma-mass spectrometry detector (IPC-ICP-MS). 2-Propanol (10%-25% gradient) replaced the previously used acetonitrile (25%-75%) as the solvent, to reduce the carbon load into the plasma. In synthetic solutions, formation of thiomolybdates was found to occur spontaneously in the presence of excess sulfide and the degree of thiolation was highest at pH 7. Excess hydroxyl led to a transformation of thiomolybdates to molybdate. Under acidic to neutral conditions, precipitation of molybdenum and hydrolysis of tetrathiomolybdate were observed. Flash-freezing was found to be suitable to stabilize tetrathiomolybdate, with 2 mM) negatively affected the detection of molybdate, which eluted mainly in the dead volume, but had no negative effect on higher thiolated molybdates. Detection limits were ∼10 nM. With the newly developed IPC-ICP-MS method, thiomolybdates were found to form spontaneously in euxinic marine waters after adding a molybdate spike and occur naturally in sulfidic geothermal waters.

  17. 行业领袖聚鹏城热议产业发展前景——记IPC WorksAsia2011高峰管理论坛

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    2011年10月28日,IPC(中国)在深圳东方银座美爵酒店举办了电子业界的高峰管理论坛,电子制造业的众多企业家在鹏城汇聚一堂。IPC WorksAsia2011论坛以“聚焦热点话题,探索发展方向”为主题。这一论坛今年在中国是首次举办,是IPC WorksAsia的一个重要组成部分,并成为IPC WorksAsia2011的一大亮点。

  18. Strategy for Coordinated EPA/Occupational Safety and Health Administration (OSHA) Implementation of the Chemical Accident Prevention Requirements of the Clean Air Act Amendments of 1990

    Science.gov (United States)

    EPA and the Occupational Safety and Health Administration (OSHA) share responsibility for prevention: OSHA has the Process Safety Management Standard to protect workers, and EPA the Risk Management Program to protect the general public and environment.

  19. When gender bumps into health and safety training: working conditions, readings and challenges drawn from a case study in an industrial chemicals company.

    Science.gov (United States)

    Vasconcelos, Ricardo; Teixeira, Sandra; Castelhano, Joana; Lacomblez, Marianne

    2012-01-01

    Health, safety and environmental issues are at present a social concern and an increasingly referred topic in the so called gender studies. This paper focuses on the relations between training, gender and risk perception in an industrial chemicals company, in Portugal, characterized by a mainly male population and by the presence of high occupational and environmental hazards. After characterizing the company and the training project that started up this reflection, the paper presents the reasons for its focus on gender followed by the essential methodological explanations: 14 interviews were made with male and female workers from the company; their content was transcribed from the audio recordings and it was systematically analyzed. A gender-attentive socio demographic analysis was also undertaken. Although at the beginning the company did not consider the gender issues as a problem nor was it the central topic of the training, which focused on the prevention of occupational and environmental hazards, the results reveal that the gender factor brought to light some working conditions, which so far have not been properly discussed within the group meetings. As a consequence, there is now room for the transformation of the representations on those working conditions.

  20. A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals.

    Science.gov (United States)

    Vandenberg, Laura N; Ågerstrand, Marlene; Beronius, Anna; Beausoleil, Claire; Bergman, Åke; Bero, Lisa A; Bornehag, Carl-Gustaf; Boyer, C Scott; Cooper, Glinda S; Cotgreave, Ian; Gee, David; Grandjean, Philippe; Guyton, Kathryn Z; Hass, Ulla; Heindel, Jerrold J; Jobling, Susan; Kidd, Karen A; Kortenkamp, Andreas; Macleod, Malcolm R; Martin, Olwenn V; Norinder, Ulf; Scheringer, Martin; Thayer, Kristina A; Toppari, Jorma; Whaley, Paul; Woodruff, Tracey J; Rudén, Christina

    2016-07-14

    The issue of endocrine disrupting chemicals (EDCs) is receiving wide attention from both the scientific and regulatory communities. Recent analyses of the EDC literature have been criticized for failing to use transparent and objective approaches to draw conclusions about the strength of evidence linking EDC exposures to adverse health or environmental outcomes. Systematic review methodologies are ideal for addressing this issue as they provide transparent and consistent approaches to study selection and evaluation. Objective methods are needed for integrating the multiple streams of evidence (epidemiology, wildlife, laboratory animal, in vitro, and in silico data) that are relevant in assessing EDCs. We have developed a framework for the systematic review and integrated assessment (SYRINA) of EDC studies. The framework was designed for use with the International Program on Chemical Safety (IPCS) and World Health Organization (WHO) definition of an EDC, which requires appraisal of evidence regarding 1) association between exposure and an adverse effect, 2) association between exposure and endocrine disrupting activity, and 3) a plausible link between the adverse effect and the endocrine disrupting activity. Building from existing methodologies for evaluating and synthesizing evidence, the SYRINA framework includes seven steps: 1) Formulate the problem; 2) Develop the review protocol; 3) Identify relevant evidence; 4) Evaluate evidence from individual studies; 5) Summarize and evaluate each stream of evidence; 6) Integrate evidence across all streams; 7) Draw conclusions, make recommendations, and evaluate uncertainties. The proposed method is tailored to the IPCS/WHO definition of an EDC but offers flexibility for use in the context of other definitions of EDCs. When using the SYRINA framework, the overall objective is to provide the evidence base needed to support decision making, including any action to avoid/minimise potential adverse effects of exposures. This

  1. EXPERIMENTAL DEVICE DESIGN OF DC MOTOR CONTROL BASED ON IPC%基于IPC的直流电机控制实验装置设计

    Institute of Scientific and Technical Information of China (English)

    张锐; 李学远; 陈林; 孙琦

    2006-01-01

    介绍了工业控制计算机(IPC)在工业自动化领域中对直流机控制的应用,以工控机作为实验平台,设计了IPC测控系统之一的直流机测控子系统的实验装置,叙述了如何用IPC进行直流机转速的脉冲调宽式(PWM)控制,并通过软件实现在多任务实时操作系统(MROS)中直流机的速度测控和速度曲线绘制.

  2. AGV assembly robot based on IPC control system design%基于工控机的AGV装配机器人控制系统设计

    Institute of Scientific and Technical Information of China (English)

    徐文斌; 蔡容华; 林科荣; 孙广大; 陈彦波; 谭柱

    2013-01-01

    设计了一套基于工控机的双举升AGV装配机器人的控制系统.采用磁带导航完成寻线功能,采用PSD完成AGV与生产线的同步检测.利用无线网卡WiFi接入网方式,通过TCP/IP协议完成AGV与监控中心的数据传输以及运行调度.%This paper designed a double lift AGV Assembly robot based on IPC control system.Tape line-tracking navigation completed features in the text,using PSD complete AGV and synchronous test line.Useing the wireless network adapter Wifi networks,TCP/IP protocol operation of data transmission,as well as complete AGV and control centre.

  3. The dependence of the soft X ray spectral slope with radio property, luminosity, and redshift, for a large sample of AGN from the Einstein IPC data base

    Science.gov (United States)

    Brunner, H.; Worrall, D. M.; Wilkes, Belinda J.; Elvis, Martin

    1989-01-01

    The dependence of the soft X-ray spectral slope on radio, optical and X-ray properties, and on redshift are reported for a large sample of Active Galactic Nuclei (AGN). The sample includes 317 optically and radio-selected AGN from a preliminary version of the Einstein Imaging Proportional Counter (IPC) quasar and AGN data base. The main results are: the difference in X-ray slope between radio-loud and radio-quiet AGN were confirmed for an independent and much larger sample of sources; a difference in X-ray slope between flat and steep radio spectrum AGN is observed only in high luminosity sub-sample; in flat radio spectrum AGNs there is an indication for a dependence of the X-ray spectral index on X-ray luminosity redshift and alpha sub 0x.

  4. Toward the definition of specific protection goals for the environmental risk assessment of chemicals: A perspective on environmental regulation in Europe.

    Science.gov (United States)

    Brown, A Ross; Whale, Graham; Jackson, Mathew; Marshall, Stuart; Hamer, Mick; Solga, Andreas; Kabouw, Patrick; Galay-Burgos, Malyka; Woods, Richard; Nadzialek, Stephanie; Maltby, Lorraine

    2017-01-01

    Programme for Chemical Safety (IPCS) definition of "adverse effect." A possible solution, which the chemical industry is currently assessing, is wider application of the ecosystem services approach proposed by the European Food Safety Authority (EFSA) for the risk assessment of PPPs. Integr Environ Assess Manag 2017;13:17-37. © 2016 SETAC.

  5. Chemical Compatibility and Safety of Imidacloprid/Flumethrin Collar (Seresto®) Concomitantly Used with Imidacloprid/Moxidectin (Advocate®, Advantage® Multi) and Emodepside/Praziquantel (Profender®) Spot-on Formulations.

    Science.gov (United States)

    Krüdewagen, Eva Maria; Remer, Carolin; Deuster, Katrin; Schunack, Bettina; Wolken, Sonja; Crafford, Dionne; Fourie, Josephus; Stanneck, Dorothee

    2015-08-01

    Safety of concomitant use of veterinary products is of clinical interest. A series of studies was performed to evaluate the chemical compatibility and short term dermal and systemic safety of an imidacloprid/flumethrin collar (Seresto(®)/ Foresto(®), Bayer) used concomitantly with spot-on or tablet formulations.Chemical compatibility was evaluated in-vitro (study reference A) on collar pieces, followed by two small, non-controlled clinical studies (study reference B) in both, cats and dogs. The studies showed, that certain solvents affected the collar in-vitro, but not in their marketed formulations.Dermal and systemic safety of different spot-on or tablet formulations was first evaluated in a small, non-controlled clinical study (study reference C) in cats and dogs, via clinical observations only, followed by controlled clinical safety studies of concomitant use with imidacloprid/ moxidectin (Advocate(®)/ Advantage(®) Multi, Bayer) in dogs and cats (study reference D) and emodepside/ praziquantel (Profender(®), Bayer) in cats (study reference E), assessing safety aspects by clinical observations and statistical analyses of hematology and clinical chemistry parameters compared to baseline values and between treated and control groups.Dermal safety findings over all clinical studies (study references B to E) matched those already described for the respective products and included transient cosmetic changes (oily hair and crystal formation) at the site of spot-on application and broken hair, transient alopecia and skin alterations at the site of collar application. There were no indications of these findings aggravating under the conditions of concurrent use. There were no systemic safety findings of clinical significance in any of the clinical safety studies (study reference C to E). Assessment of blood parameters revealed some deviations from baseline levels and from the reference range in dogs as well as in cats, but no clinical relevance could be deduced

  6. Study on the way of identification and control of safety hazard in chemical process design%化工工艺设计中安全危险的识别及控制方法探讨

    Institute of Scientific and Technical Information of China (English)

    司稳琴

    2015-01-01

    chemical technology is an important part of industrial development,which is the prerequisite for the implementation of chemical production. The chemical industry must be identified in accordance with the principle and purpose of essential safety design,so as to effectively control the hazardous factors in chemical process and realize the sustainable development of the industry.%化工工艺是工业发展的重要组成部分,是化工生产得以实施的前提.化工工业必须按照本质安全设计的原则和目的进行识别,这样才能有效控制化工工艺中危险因素,更好地实现工业的可持续发展.

  7. Fire Control Safety Inspection Management of Power Lines and Electrical Equipment in Chemical Plant%化工厂电力线路和电气设备的消防安全检查管理

    Institute of Scientific and Technical Information of China (English)

    张小洁; 马龙; 彭涛

    2013-01-01

      三大危险行业之一就是化工企业,易燃、易爆、有毒有害气体众多是化工行业的重要特点。化工厂设备众多,因此电力线路和电气设备随处可见,因此,做好化工企业的电力线路以及电气设备的消防安全检查是预防化工厂安全事故的必要措施,是保证企业安全生产的重要手段。本文针对化工厂电力线路、电缆线路、车间配电线路的安全检查,变压器、高、低压配电柜、发电机等电气设备的安全检查管理,阐述了具体要检查记录哪些数据,有哪些判断方法等。%  One of the three dangerous industry is the chemical enterprise, flammable, explosive, toxic and harmful gas is an important feature of many chemical industry. Chemical plant equipment is numerous, so the power lines and electrical equipment can be seen everywhere, therefore, fire safety inspection of power lines and electrical equipment in chemical enterprises are necessary measures to prevent accidents in chemical plant, and they are important means to ensure safety in production enterprises. According to the security check of workshop distribution power line, cable line, chemical plant, safety inspection management of high and low voltage power distribution cabinet, transformer, generator, electrical equipment, this paper expounds the concrete to check the record which data, what judgment method.

  8. Vaccine Safety

    Science.gov (United States)

    ... Vaccine Safety Shingles (Herpes Zoster) Vaccine Safety Smallpox Vaccine Safety Common Concerns Adjuvants Autism CDC Statement: 2004 Pediatrics Paper on MMR and Autism Fainting (Syncope) Febrile ...

  9. 化工企业安全生产标准化“三项达标”建设探讨%Chemical Enterprise Work Safety Standardization “Three Standard” Construction Discussed

    Institute of Scientific and Technical Information of China (English)

    陈东

    2014-01-01

    Chemical enterprises to carry out the construction of work safety standardization,is an important basis for the government to implement safety classification guidance and supervision. It is to carry out the safe production responsi-bility, regulating the behavior of safe production, enhance the level of safety management, effective way and important means to prevent the accident. This paper focuses on the chemical enterprise work safety standardization“three standard”construction?meaning?relationship and ways of implementation and puts forward four suggestions to create work.%化工企业开展安全生产标准化建设,是政府实施安全生产分类指导、分级监管的重要依据,是落实安全生产主体责任、规范安全生产行为、提升安全管理水平,有效防范事故发生的必要途径和重要手段。重点论述化工企业安全生产标准化“三项达标”建设的含义、关系、实施途径并提出4点创建工作建议。

  10. Hurricane Safety

    Science.gov (United States)

    ... English Hurricane Safety Checklist - Arabic Hurricane Safety Checklist - Chinese Hurricane Safety Checklist - French Hurricane Safety Checklist - Haitian ... Cross serves in the US, its territories and military installations around the world. Please try again. Your ...

  11. 危险化学品企业安全验收评价结论量化分析%Quantitative analysis on conclusions of safety assessment upon completion for hazard chemical enterprises

    Institute of Scientific and Technical Information of China (English)

    葛秀坤; 邵辉; 赵庆贤; 邢志祥; 郝永梅

    2012-01-01

    为了使危险化学品企业安全验收评价结论更加准确、客观,根据安全验收评价结论编制的原则和相关导则,从法律法规符合性、外部安全条件、总平面布局及建筑结构、主要生产装置设施、主要储存装置设施、公用工程和辅助设施、安全管理及从业人员条件和应急救援等八个方面建立了安全验收评价结论定量评估指标体系.基于层次分析法确定各级指标权重,建立了安全验收评价结论定量评估模型.为方便对安全验收评价结论进行准确、快速地评估,利用EXCEL软件建立了安全验收评价结论定量评估系统.该评估模型和评估系统可以客观、快速、准确地对危险化学品企业安全验收评价结论进行定量评估.%In order to make safety assessment upon completion of hazard chemical enterprises more accurate and objective, according to compilation principles of safety assessment upon completion and related guidelines, a quantitative evaluation index system of evaluation was established from eight aspects, including laws and regulations eon-formability, foreign safety situation, general layout, main production equipments, main store equipments, public project and auxiliary facilities, safety mangement and employment conditions and-emergency rescue. The index weights were made by Analytic Hierarchy Process method and quantitative assessment models on conclusions of safety assessment upon completion were established. In order to make safety assessment upon completion conclusion more accurate and faster, a quantitative evaluation system on conclusions of safety assessment upon completion was built by EXCEL software. The assessment models and system can quantify conclusions of safety assessment upon completion for hazard chemical enterprises more objectively, quickly and accurately.

  12. Guide for Science Laboratory Safety.

    Science.gov (United States)

    McDermott, John J.

    General and specific safety procedures and recommendations for secondary school science laboratories are provided in this guide. Areas of concern include: (1) chemicals (storage, disposal, toxicity, unstable and incompatible chemicals); (2) microorganisms; (3) plants; (4) animals; (5) electricity; (6) lasers; (7) rockets; (8) eye safety and…

  13. 一种新型危险化工工艺安全评估方法的设计%Design of a new method for safety assessment on dangerous chemical process

    Institute of Scientific and Technical Information of China (English)

    周仲园; 陶刚; 张礼敬; 张良; 潘毅伟

    2012-01-01

    在安全生产过程中,建设项目风险评价在我国经过几十年的发展,无论在模型亦是方法上均有所进步,但对化工项目进行危险化工工艺风险等级评价的研究并不多见.本文按照危险化工工艺表征涉及的影响因素,在参考了日本劳动省“六阶段”的定量评价表以及危险度评价法并对15种危险化工工艺定性分析的基础上,提出了一种基于危险度评价法的更为全面的危险化工工艺辨识方法.该评价方法可用于确定危险化工工艺的风险等级.为化工企业工艺危险的实时评估和安全管理提供技术支撑和科学途径.%With the development of chemical technology, process safety in the safety production is an important part of chemical safety production. In more than a decade in China, risk assessment of construction program has heen improved in terms of either models or methodology. However, there are few studies on risk rank assessment for dangerous chemical process. On the basis of the "Six phase" quantitative evaluation coming from the Japanese Ministry of Labour and the risk assessment method, a more comprehensive risk identification method for chemical processes was proposed in order to quickly and easily assess the risk of chemical process risk level. This model would give assistance to real-time process risk assessments and corresponding management, and also provide help and scientific way for the government in the safety management of dangerous chemical process .

  14. Safety advice sheets

    CERN Multimedia

    HSE Unit

    2013-01-01

    You never know when you might be faced with questions such as: when/how should I dispose of a gas canister? Where can I find an inspection report? How should I handle/store/dispose of a chemical substance…?   The SI section of the DGS/SEE Group is primarily responsible for safety inspections, evaluating the safety conditions of equipment items, premises and facilities. On top of this core task, it also regularly issues “Safety Advice Sheets” on various topics, designed to be of assistance to users but also to recall and reinforce safety rules and procedures. These clear and concise sheets, complete with illustrations, are easy to display in the appropriate areas. The following safety advice sheets have been issued so far: Other sheets will be published shortly. Suggestions are welcome and should be sent to the SI section of the DGS/SEE Group. Please send enquiries to general-safety-visits.service@cern.ch.

  15. An Analysis of Cultivation of Safety Consciousness in Teaching Engineering Chemical Experiment%浅谈工科化学实验教学中安全意识的培养

    Institute of Scientific and Technical Information of China (English)

    石振武

    2012-01-01

    根据工科化学实验教学的特点,在实验教学过程中采用实验前安全意识的教育、实验中安全制度的检查以及实验后安全防范的复查等措施,以此着重培养工科本科生的安全意识。在保证化学实验教学顺利进行和提高化学实验教学质量的同时,也有助于工科本科生综合素质的全面提高。%According to the characteristics of the experimental teaching of engineering chemistry,the education of safety consciousness before the experiment,inspection of safety regulation in conduction of experiment and safety measures after the completion of experiment were adopted to cultivate the engineering undergraduate safety consciousness.When the smooth conduction of chemical experiment teaching is ensured and the quality of chemistry experiment teaching improved,the engineering undergraduate all-round comprehensive quality can be improved.

  16. [Evaluation of the risk of delayed adverse effects of chronic combined exposure to radiation and chemical factors with the purpose to ensure safety in orbital and exploration space missions].

    Science.gov (United States)

    Shafirkin, A V; Mukhamedieva, L N; Tatarkin, S V; Barantseva, M Iu

    2012-01-01

    The work had the aim to anatomize the existing issues with providing safety in extended orbital and exploration missions for ensuing estimation of actual values of the total radiation risk for the crew, and risks of other delayed effects of simultaneous exposure to ionizing radiation and chemical pollutants in cabin air, and a number of other stressful factors inevitable in space flight. The flow of chronic experiments for separate and combined studies with reproduction of air makeup and radiation doses in actual orbital and predicted exploration missions is outlined. To set safety limits, new approaches should be applied to the description of gradual norm degradation to pathologies in addition to several generalized quantitative indices of adaptation and straining of the regulatory systems, as well as of effectiveness of the compensatory body reserve against separate and combined exposure.

  17. Human Stem Cell Derived Cardiomyocytes: An Alternative Model to Evaluate Environmental Chemical Cardiac Safety and Development of Predictive Adverse Outcome Pathways

    Science.gov (United States)

    Chemical spills and associated deaths in the US has increased 2.6-fold and 16-fold from 1983 to 2012, respectfully. In addition, the number of chemicals to which humans are exposed to in the environment has increased almost 10-fold from 2001 to 2013 within the US. Internationally...

  18. Human Stem Cell Derived Cardiomyocytes: An Alternative Model to Evaluate Environmental Chemical Cardiac Safety and Development of Predictive Adverse Outcome Pathways

    Science.gov (United States)

    Chemical spills and associated deaths in the US has increased 2.6-fold and 16-fold from 1983 to 2012, respectfully. In addition, the number of chemicals to which humans are exposed to in the environment has increased almost 10-fold from 2001 to 2013 within the US. Internationally...

  19. TIS General Safety Group Annual Report 2000

    CERN Document Server

    Weingarten, W

    2001-01-01

    This report summarises the main activities of the General Safety (GS) Group of the Technical Inspection and Safety Division (TIS) during the year 2000, and the results obtained. The different topics in which the Group is active are covered: general safety inspections and ergonomy, electrical, chemistry and gas safety, chemical pollution containment and control, industrial hygiene, the safety of civil engineering works and outside contractors, fire prevention and the safety aspects of the LHC experiments.

  20. Model review and evaluation for application in DOE safety basis documentation of chemical accidents - modeling guidance for atmospheric dispersion and consequence assessment

    Energy Technology Data Exchange (ETDEWEB)

    Lazaro, M. A. [Argonne National Lab. (ANL), Argonne, IL (United States); Woodarad, K. [Argonne National Lab. (ANL), Argonne, IL (United States); Hanna, S. R. [Argonne National Lab. (ANL), Argonne, IL (United States); Hesse, D. J. [Argonne National Lab. (ANL), Argonne, IL (United States); Huang, J. -C. [Argonne National Lab. (ANL), Argonne, IL (United States); Lewis, J. [Argonne National Lab. (ANL), Argonne, IL (United States); Mazzola, C. A. [Argonne National Lab. (ANL), Argonne, IL (United States)

    1997-09-01

    The U.S. Department of Energy (DOE), through its Defense Programs (DP), Office of Engineering and Operations Suppon, established the Accident Phenomenology and Consequence (AP AC) Methodology Evaluation Program to identify and evaluate methodologies and computer codes to support accident phenomenological and consequence calculations for both radiological and nonradiological materials at DOE facilities and to identify development needs. The program is also intended to define and recommend "best or good engineering/safety analysis practices" to be followed in preparing ''design or beyond design basis" assessments to be included in DOE nuclear and nonnuclear facility safety documents. The AP AC effort is intended to provide scientifically sound and more consistent analytical approaches, by identifying model selection procedures and application methodologies, in order to enhance safety analysis activities throughout the DOE complex.

  1. In vitro dermal absorption rate testing of certain chemicals of interest to the Occupational Safety and Health Administration: summary and evaluation of USEPA's mandated testing.

    Science.gov (United States)

    Fasano, William J; McDougal, James N

    2008-07-01

    In 2004, the United States Environmental Protection Agency (USEPA) published a final test rule in the US Federal Register requiring in vitro dermal penetration rate testing for selected industrial chemicals. The test rule described procedures for determining a permeability coefficient (Kp) and two short-term dermal absorption rates at 10 and 60min using human cadaver skin mounted in an in vitro diffusion cell model. According to the USEPA announcement, the selected chemicals were to be spiked with their radiolabeled form and tested in either water, isopropyl myristate (IPM) or neat depending on their physical character at room temperature, their aqueous solubility, their potential to damage the skin and their ability to achieve the study endpoints as prescribed. Overall, and for the majority of chemicals, the short-term absorption rates were higher at 10min than at 60min and the portion of applied dose remaining in the skin at the end of the exposure period was greater than the portion of dose that had penetrated through the skin and was detected in the receptor solution. In contrast to this, the amount of chemical in the receptor solution at study termination for the Kp (steady-state) experiments was greater than the amount remaining in the skin. For the Kp experiments, which lasted from 2 to 48h, a majority of skins exposed to neat chemical exhibited a reduced barrier function. However, integrity was mostly unaltered for skins from the short-term experiments and Kp experiments using chemicals applied either in water or IPM. Quantitative structure activity relationship (QSAR) model-predicted Kp values were in fair agreement with experimental data for those chemicals that were applied in a water vehicle when the integrity of the skin was not compromised. However, QSAR-derived Kp values were not predictive for those chemicals when applied in IPM vehicle or neat. Absorption predictions, based on the measured Kp and steady-state flux data for chemicals applied in

  2. Safety first

    CERN Multimedia

    2012-01-01

    Safety is a priority for CERN. That is a message I conveyed in my New Year’s address and that I reiterated at one of the first Enlarged Directorate meetings of 2012 when I outlined five key safety objectives for the year, designed and implemented according to accepted international standards.   As we move from spring to summer, it’s time to take stock of how we are doing. Objective number one for 2012, which overarches everything else, is to limit the number of incidents in the workplace. That means systematically investigating and acting on every incident that involves work stoppage, along with all the most frequent workplace accidents: falls, trips and slips. The performance indicator we set ourselves is the percentage of investigations and follow-ups completed. Year on year, these figures are rising but we can never be complacent, and must strive to reach and sustain 100% follow-up. The second objective is to improve hazard control, with a focus in 2012 on chemical ha...

  3. 浅谈疾病预防控制机构理化实验室的安全与防护%Safety and Protection of Physical and Chemical Laboratories in Disease Control and Prevention Institutions

    Institute of Scientific and Technical Information of China (English)

    顾信君

    2012-01-01

    To identify laboratorial safety risks and explore appropriate protective measures by local practice in physical and chemical laboratories in disease control and prevention institutions.%针对疾病预防控制机构理化实验室所存在的各类安全隐患,结合本实验室工作中总结的经验,就实验室安全隐患的识别和相应的防护措施进行探讨.

  4. Safety culture

    Energy Technology Data Exchange (ETDEWEB)

    Keen, L.J. [Canadian Nuclear Safety Commission, Ottawa, Ontario (Canada)

    2003-07-01

    Safety culture has become a topic of increasing interest for industry and regulators as issues are raised on safety problems around the world. The keys to safety culture are organizational effectiveness, effective communications, organizational learning, and a culture that encourages the identification and resolution of safety issues. The necessity of a strong safety culture places an onus on all of us to continually question whether the safety measures already in place are sufficient, and are being applied. (author)

  5. Integrating process safety with molecular modeling-based risk assessment of chemicals within the REACH regulatory framework: benefits and future challenges.

    Science.gov (United States)

    Lewis, Amanda; Kazantzis, Nikolaos; Fishtik, Ilie; Wilcox, Jennifer

    2007-04-11

    Registration, evaluation and authorization of chemicals (REACH) represents a recent regulatory initiative by the European union commission to protect human health and the environment from potentially hazardous chemicals. Under REACH, all stakeholders must submit (thermo)physical, thermochemical, and toxicological data for certain chemicals. The commission's impact assessment studies estimate that the costs of REACH will be approximately 3-5 billion Euros. The present study advocates the systematic incorporation of computational chemistry and computer-assisted chemical risk assessment methods into REACH to reduce regulatory compliance costs. Currently powerful computer-aided ab initio techniques can be used to generate predictions of key properties of broad classes of chemicals, without resorting to costly experimentation and potentially hazardous testing. These data could be integrated into a centralized IT decision and compliance support system, and stored in a retrievable, easily communicable manner should new regulatory and/or production requirements necessitate the introduction of different uses of chemicals under different conditions. For illustration purposes, ab initio calculations are performed on heterocyclic nitrogen-containing compounds which currently serve as high energy density materials in the chemical industry. Since investigations of these compounds are still in their infancy, stability studies are imperative regarding their safe handling and storage, as well as registration under REACH.

  6. Recovery and reprocessing of legacy geophysical data from the archives of the State Company of Geology and Mining (GEOSURV) of Iraq and Iraq Petroleum Company (IPC)

    Science.gov (United States)

    Smith, D.V.; Drenth, B.R.; Fairhead, J.D.; Lei, K.; Dark, J.A.; Al-Bassam, K.

    2011-01-01

    Aeromagnetic data belonging to the State Company of Geology and Mining of Iraq (GEOSURV) have been recovered from magnetic tapes and early paper maps. In 1974 a national airborne survey was flown by the French firm Compagnie General de Geophysique (CGG). Following the survey the magnetic data were stored on magnetic tapes within an air conditioned archive run by GEOSURV. In 1990, the power supply to the archive was cut resulting in the present-day poor condition of the tapes. Frontier Processing Company and the U.S. Geological Survey (USGS) have been able to recover over 99 percent of the original digital data from the CGG tapes. Preliminary reprocessing of the data yielded a total magnetic field anomaly map that reveals fine structures not evident in available published maps. Successful restoration of these comprehensive, high quality digital datasets obviates the need to resurvey the entire country, thereby saving considerable time and money. These data were delivered to GEOSURV in a standard format for further analysis and interpretation. A parallel effort by GETECH concentrated on recovering the legacy gravity data from the original field data sheets archived by IPC (Iraq Petroleum Company). These data have been compiled with more recent GEOSURV sponsored surveys thus allowing for the first time a comprehensive digital and unified national gravity database to be constructed with full principal facts. Figure 1 shows the final aeromagnetic and gravity data coverage of Iraq. The only part of Iraq lacking gravity and aeromagnetic data coverage is the mountainous areas of the Kurdish region of northeastern Iraq. Joint interpretation of the magnetic and gravity data will help guide future geophysical investigations by GEOSURV, whose ultimate aim is to discover economical mineral and energy resources. ?? 2011 Society of Exploration Geophysicists.

  7. Computational investigation of the Lewis acidity in three-dimensional and corresponding two-dimensional zeolites: UTL vs IPC-1P.

    Science.gov (United States)

    Thang, Ho Viet; Rubeš, Miroslav; Bludský, Ota; Nachtigall, Petr

    2014-09-04

    The adsorption and catalytic properties of three-dimensional zeolite UTL were investigated computationally along with properties of its two-dimensional analogue IPC-1P that can be obtained from UTL by a removal of D4R units. Adsorption properties and Lewis acidity of extra-framework Li(+) sites were investigated for both two- and three-dimensional forms of UTL using the carbon monoxide as a probe molecule. The CO adsorption enthalpies, calculated with various dispersion-corrected DFT methods, including DFT/CC, DFT-D2, and vdW-DF2, and the CO stretching frequencies obtained with the νCO/rCO correlation method are compared for corresponding Li(+) sites in 3D and 2D UTL zeolite. For the majority of framework Al positions the Li(+) cation is preferably located in one of the channel wall sites and such sites remains unchanged upon the 3D → 2D UTL transformation; consequently, the adsorption enthalpies become only slightly smaller in 2D UTL (less than 3 kJ mol(-1)) due to the missing part of dispersion interactions and νCO becomes also only up to 5 cm(-1) smaller in 2D UTL due to the missing repulsion with framework oxygen atoms from the opposite site of the zeolite channel (effect from the top). However, when Li(+) is located in the intersection site in 3D UTL (about 20% probability), its coordination with the framework is significantly increased in 2D UTL and that is accompanied by significant decrease of both νCO (about 20 cm(-1)) and adsorption enthalpy (about 20 kJ mol(-1)). Because the intersection sites in 3D UTL are the most active adsorption and catalytic Lewis sites, the results reported herein suggest that the 3D → 2D transformation of UTL zeolite is connected with partial decrease of zeolite activity in processes driven by Lewis acid sites.

  8. 10 April 2014: Safety Day at CERN

    CERN Multimedia

    Antonella Del Rosso

    2014-01-01

    A wide variety of chemicals is used every day in the different laboratories and workshops around CERN. Potentially toxic, corrosive, polluting or hazardous in other ways, these chemicals all have to be handled carefully, as we will be reminded by the Safety Day campaign to be held by the HSE Unit on 10 April to mark World Day for Safety and Health at Work.   The use of chemicals at CERN is regulated by "Safety Regulation SR-C, Chemical Agents", which defines the minimum health and safety protection requirements for people exposed to the potentially hazardous effects of dangerous chemicals. This regulation is complemented by other Safety guides. Regretfully, despite strict procedures and regular inspections, accidents caused by the improper use of chemicals do occur every year. "Unfortunately, each year we see a small number of accidents related to the handling of chemicals," confirms chemicals expert Jonathan Gulley, who is a member of the Prevention and Sa...

  9. Safety approach for a facility coupling a nuclear reactor to a chemical plant, generic principles and application to a hydrogen production process; Approche de surete d'une installation associant un reacteur nucleaire a une usine chimique, principes generiques et application a un procede de production d'hydrogene

    Energy Technology Data Exchange (ETDEWEB)

    Bertrand, F.; Barbier, D.; Bassi, A. [CEA Cadarache, Direction de l' Energie Nucleaire, 13 - Saint-Paul-lez-Durance (France). Dept. d' Etudes des Reacteurs

    2006-07-01

    The aim of this paper is to propose an overall safety approach devoted to the coupling on a same site of a nuclear reactor to a plant of hydrogen production. Such facilities depend on their own safety principles and practices and are submitted to their own regulation. Therefore, the approach presented here takes into account the aforementioned constraints and takes into consideration the various risks on the site in the design process of the coupling system. This approach relying on the defence in depth concept declined in five levels led to a generalization of the notion of physical barriers and safety functions applied in the French nuclear safety approach. Three main safety functions can be considered for the whole coupled facility : the control of the nuclear and chemical reactivity, the power extraction and the confinement of hazardous materials. Moreover, according to the concept of defence in depth, different plant conditions (normal, incidents and accidents) have been analyzed for the whole facility. Furthermore, the safety approach proposed for the chemical plant is aimed to select reference scenarios taking into account their probability and their consequences on the basis of the methodology presented in the ARAMIS European project. Finally, the purpose of the safety analysis of the chemical plant is the assessment of adequate safety distances to protect people outside of the site as well as the coupling system and, above everything, the nuclear reactor containment. In other respects, a progressive response aiming to avoid the reactor scram is proposed to manage with incidents. (authors)

  10. A Literature Review - Problem Definition Studies on Selected Toxic Chemicals. Volume 6. Occupational Health and Safety and Environmental Aspects of Urea-Formaldehyde Resins

    Science.gov (United States)

    1978-04-01

    com- plications during pregnancy ; children born were underw-eight (17). 3- Skin Contact Formaldehyde released from urea-formaldehyde resins may cause ...formaldehyde resins on carcinogenesis, Mta2genesis or teratogenesis were found in the literature, nor were reports on their effects on wildlife or aquatic...safety practices involve the prevention of hazards caused by the release of formaldehyde. Special sampling and analytical method- are discussed. IIT

  11. Scientific Opinion on the safety and efficacy of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers (chemical group 6 when used as flavourings for all animal species

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP

    2012-11-01

    Full Text Available Chemical group 6 consists of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers, of which 13 are currently authorised for use as flavours in food. The high use level proposed by the applicant for linalool (25 mg/kg complete feed is safe for salmonids, veal calves, cattle for fattening and pets (excluding cats without a margin of safety with the exception of dogs (SF = 1.4. The safe use level for pigs and dairy cows is 20, for piglets 12 and for poultry 10 mg/kg complete feed. The high use level of 5 mg/kg complete feed for linalyl acetate, linalyl butyrate, linalyl formate, linalyl propionate, linalyl isobutyrate, terpineol, α-terpineol and terpineol acetate and 4-terpinenol is safe for all species with a margin of safety of 1.2 to 12. For nerolidol, 2-methyl-1-phenylpropan-2-ol and 2-(4-methylphenylpropan-2-ol, the maximum safe concentration is 1 mg/kg complete feed for pigs and poultry and 1.5 mg/kg complete feed for all other species. The absence of a margin of safety would not allow the simultaneous administration in feed and water for drinking of the following compounds: linalool, nerolidol, 2-methyl-1-phenylpropan-2-ol and 2-(4methylphenylpropan-2-ol. No safety concern would arise for the consumer from the use of compounds belonging to CG 6 up to the highest safe level in feedingstuffs for all animal species. All compounds should be considered as irritants to skin, eyes and respiratory tract, and as skin sensitisers. All compounds of CG 6 are predicted to be safe to the soil compartment when used at levels safe to the target species. Using predictions based on chemical structure, 2-methyl-1-phenylpropan-2-ol and 2-(4-methylphenylpropan-2-ol were estimated to be safe to aquatic compartments. In the absence of experimental data, safety to aquatic compartments could not be established for linalyl butyrate, linalyl isobutyrate, terpineol acetate, 4

  12. 基于多Agent的危险化学品安全生产信息采集系统设计%Design of information collection system of hazardous chemical work-safety based on multi-agent

    Institute of Scientific and Technical Information of China (English)

    刘婕; 周铝; 王江

    2012-01-01

    Work-safety monitoring is a critical governmental responsibility, which directly affects human safety as well as protects capital assets. In this regard, hazardous chemical monitoring is of paramount importance. A well-developed safety monitoring information system has been proven to be a feasible solution to this problem, which can lower the amount of required work while increase the effectiveness of the monitoring process. A distributed agent information-collection model was established, which composed by management agent, collection agent, diagnosis a-gent and communication agent. The system was used to connect industrial enterprises located in Bureau of work safety supervision center through to the Hazardous Chemical Information Center at the Enterprise, so as to monitor the work safety of their manufacturing processes. A system based on multi-agent was applied to of production state parameters for hazard sources. The function and structure of all types of agent were designed. The system was used to data acquisition, monitoring and analysis on the state parameters in production of hazardous chemical , which lo-cated in different industrial enterprises, so as to predict or diagnose abnormal conditions in the manufacturing process. Thereby, through the cooperation and parallel solution, the problem of information-collection for hazardous chemicals work safety can be solved.%安全生产监管是政府的重要职责,直接关系到国家财产和人民生命安全.安全生产监管中,以危险化学品的监管为重中之重.提高安全生产监管的信息化程度是降低监管强度、提高监管效率行之有效的方法.构建了由管理Agent、采集Agent、故障诊断Agent、通信Agent组成的分布式信息采集多Agent系统,将安监局监管中心对危险化学品生产过程监管的信息采集任务下移到企业端,利用多Agent系统实现危险源生产状态参数的采集、监控及分析;设计了该信息采集系统各

  13. Chemical process hazards analysis

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    The Office of Worker Health and Safety (EH-5) under the Assistant Secretary for the Environment, Safety and Health of the US Department (DOE) has published two handbooks for use by DOE contractors managing facilities and processes covered by the Occupational Safety and Health Administration (OSHA) Rule for Process Safety Management of Highly Hazardous Chemicals (29 CFR 1910.119), herein referred to as the PSM Rule. The PSM Rule contains an integrated set of chemical process safety management elements designed to prevent chemical releases that can lead to catastrophic fires, explosions, or toxic exposures. The purpose of the two handbooks, ``Process Safety Management for Highly Hazardous Chemicals`` and ``Chemical Process Hazards Analysis,`` is to facilitate implementation of the provisions of the PSM Rule within the DOE. The purpose of this handbook ``Chemical Process Hazards Analysis,`` is to facilitate, within the DOE, the performance of chemical process hazards analyses (PrHAs) as required under the PSM Rule. It provides basic information for the performance of PrHAs, and should not be considered a complete resource on PrHA methods. Likewise, to determine if a facility is covered by the PSM rule, the reader should refer to the handbook, ``Process Safety Management for Highly Hazardous Chemicals`` (DOE- HDBK-1101-96). Promulgation of the PSM Rule has heightened the awareness of chemical safety management issues within the DOE. This handbook is intended for use by DOE facilities and processes covered by the PSM rule to facilitate contractor implementation of the PrHA element of the PSM Rule. However, contractors whose facilities and processes not covered by the PSM Rule may also use this handbook as a basis for conducting process hazards analyses as part of their good management practices. This handbook explains the minimum requirements for PrHAs outlined in the PSM Rule. Nowhere have requirements been added beyond what is specifically required by the rule.

  14. Health, safety and environmental requirements for composite materials

    Science.gov (United States)

    Hazer, Kathleen A.

    1994-01-01

    The health, safety and environmental requirements for the production of composite materials are discussed. The areas covered include: (1) chemical identification for each chemical; (2) toxicology; (3) industrial hygiene; (4) fire and safety; (5) environmental aspects; and (6) medical concerns.

  15. How to control chemical hazards

    CERN Multimedia

    2012-01-01

    Improving protection against chemical hazards is one of the 2012 CERN safety objectives identified by the Director General. Identifying and drawing up a complete inventory of chemicals, and assessing the associated risks are important steps in this direction.   The HSE Unit has drawn up safety rules, guidelines and forms to help you to meet this objective. We would like to draw your attention to: • safety guidelines C-0-0-1 and C-1-0-2 (now also available in French), which deal with the identification of hazardous chemicals and the assessment of chemical risk; • safety guideline C-1-0-1, which deals with the storage of hazardous chemicals. All safety documents can be consulted at: cern.ch/regles-securite The HSE Unit will be happy to answer any questions you may have. Write to us at: safety-general@cern.ch The HSE Unit

  16. Chemical Data Access Tool

    Data.gov (United States)

    U.S. Environmental Protection Agency — This tool is intended to aid individuals interested in learning more about chemicals that are manufactured or imported into the United States. Health and safety...

  17. Chemical Accident Prevention Publications

    Science.gov (United States)

    These include chemical safety alerts, emergency preparedness and prevention advisories, and topical backgrounders. Excess flow valves, protecting workers in ethylene oxide sterilization facilities, reactivity hazards, and delayed coker units are covered.

  18. The General Safety Group Annual Report 2001/2002

    CERN Document Server

    Weingarten, W

    2003-01-01

    This report summarizes the main activities of the General Safety (GS) Group of the Technical Inspection and Safety Division during 2001 and 2002, and the results obtained. The different topics in which the group is active are covered: general safety inspections and ergonomics, electrical, chemical and gas safety, chemical pollution containment and control, industrial hygiene, the safety of civil engineering works and outside contractors, fire prevention and the safety aspects of the LHC experiments.

  19. [The urgency of the application of the medical sanitary passport in the system for chemical safety in the areas of location of high-risk chemical facilities in the Russian Federation].

    Science.gov (United States)

    Kombarova, M Iu; Radilov, A S; Dulov, S A

    2012-01-01

    The main provisions concerning the need for a creation of medical and sanitary passport for territories in the protective measures zones (PMZ) of storage facilities and facilities for the destruction of chemical weapons (FDCW) are presented in the article. The assessment of results of certification of the territory of PMZ and FDCW in "Maradykovsky" in the Kirov region has been done.

  20. Bromine Safety

    Energy Technology Data Exchange (ETDEWEB)

    Meyers, B

    2001-04-09

    The production and handling in 1999 of about 200 million kilograms of bromine plus substantial derivatives thereof by Great Lakes Chemical Corp. and Albemarle Corporation in their southern Arkansas refineries gave OSHA Occupational Injury/Illness Rates (OIIR) in the range of 0.74 to 1.60 reportable OIIRs per 200,000 man hours. OIIRs for similar industries and a wide selection of other U.S. industries range from 1.6 to 23.9 in the most recent OSHA report. Occupational fatalities for the two companies in 1999 were zero compared to a range in the U.S.of zero for all computer manufacturing to 0.0445 percent for all of agriculture, forestry and fishing in the most recent OSHA report. These results show that bromine and its compounds can be considered as safe chemicals as a result of the bromine safety standards and practices at the two companies. The use of hydrobromic acid as an electrical energy storage medium in reversible PEM fuel cells is discussed. A study in 1979 of 20 megawatt halogen working fluid power plants by Oronzio de Nora Group found such energy to cost 2 to 2.5 times the prevailing base rate at that time. New conditions may reduce this relative cost. The energy storage aspect allows energy delivery at maximum demand times where the energy commands premium rates. The study also found marginal cost and performance advantages for hydrobromic acid over hydrochloric acid working fluid. Separate studies in the late 70s by General Electric also showed marginal performance advantages for hydrobromic acid.

  1. Scientific Opinion on the safety and efficacy of glycyrrhizic acid ammoniated (chemical group 30, miscellaneous substances when used as a flavouring for all animal species

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP

    2015-01-01

    Full Text Available Glycyrrhizic acid is extracted from the dried and ground rhizome and root portions of the perennial leguminous plant Glycyrrhiza glabra L., native to southern Europe and Central Asia, or other species of the genus Glycyrrhiza. It is currently listed in the register of flavouring substances, allowing its use in food without restriction. Glycyrrhyzic acid ammoniated is safe at the concentration of 1 mg/kg complete feed for all species, except chickens for fattening and laying hens. For these two categories, a safe concentration of 0.3 mg/kg complete feed applies. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP cannot conclude on the safety of the additive used in water for drinking. The FEEDAP Panel considers that the use of glycyrrhizic acid ammoniated in animal nutrition would not measurably increase consumer exposure. In the absence of data on user safety, the FEEDAP Panel considers it prudent to treat glycyrrhizic acid ammoniated as an irritant to skin, eyes and respiratory tract and as a skin sensitiser. The use of glycyrrhizic acid ammoniated in animal feeds would not pose a risk to the environment. As glycyrrhizic acid ammoniated is used in food as a flavouring, no further demonstration of efficacy is necessary.

  2. INTEGRATED RISK ASSESSMENT - RESULTS OF AN INTERNATIONAL WORKSHOP

    Science.gov (United States)

    The UNEP/ILO/WHO International Programme on Chemical Safety (IPCS), the Organization for Economic Cooperation and Development (OECD), and the U.S. Environmental Protection Agency (USEPA) have developed a collaborative partnership to foster integration of assessment approaches to ...

  3. Plant-beneficial elements status assessment in soil-plant system in the vicinity of a chemical industry complex: shedding light on forage grass safety issues.

    Science.gov (United States)

    Anjum, Naser A; Duarte, Armando C; Pereira, Eduarda; Ahmad, Iqbal

    2015-02-01

    Human health is closely linked with soils via plants, grazers, or plant-based products. This study estimated plant-beneficial elements (macronutrients: K, P; secondary macronutrients: Ca, Mg; micronutrients: Mo, Mn, Na, Ni, Se) in both soils and shoots of two forage grass species (Eriophorum angustifolium and Lolium perenne) prevalent in the vicinity of a chemical industry complex (Estarreja, Portugal). Both soils and plants from the chemical industrial areas exhibited differential concentrations of the studied elements. In soils, the role of contamination was evidenced as insignificant in context of its impact on all the tested macro and secondary macronutrients except P, and micronutrients such as Mo and Ni. In forage grass plant shoots, the role of contamination was evidenced as insignificant in relation to its impact on all the tested macro and secondary macronutrients except K. Between the two forage grass plants, high Se-harboring L. perenne cannot be recommended for its use as animal feed.

  4. 基于 IP C的高速烟支质量检测系统设计实现%Design and implementation of high-speed cigarette quality inspection system based on IPC

    Institute of Scientific and Technical Information of China (English)

    彭峋

    2013-01-01

      国内卷接机组烟支质量检测系统均采用分立的独立机箱设计,抗干扰能力差,故障率高,可靠性和可维修性低,存在着误剔和漏剔现象。为此,设计了基于IPC的高速烟支质量检测系统。该系统采用IPC作为系统平台,外围数据通过EtherCAT工业以太网,实时、高速传送到IPC控制核心,并通过TwinCAT实时处理系统,实现了烟支质量检测功能。该系统已在实际生产中应用,实践证明,系统性能稳定、工作可靠。%The local cigarette inspection system all adopt independent unit design .The system had the disadvantages of poor resistance to disturbance and frequently machine failure which resulted in low reliability and poor maintainability , and the system exists the problem of fail to identify the fault cigarette exactly .Therefore , the high speed cigarette quality inspection system based on IPC was designed .The system uses IPC as the system platform .The peripheral data through the EtherCAT industrial Ethernet , real-time, high speed is transmitted to the core of IPC control .And through the real -time processing system of TwinCAT , the cigarette quality detection function is achieved .The system has been applied in actual production .The system performance is stable and work is reliable .

  5. Study on Highway Service Area Classification by Safety of Hazardous Chemicals Transportation%基于危化品运输安全的服务区分类

    Institute of Scientific and Technical Information of China (English)

    潘玲; 刘万能; 朱锐

    2014-01-01

    From a security perspective,according to the demand characteristics of hazardous chemical vehicles and the overall functionalities of highway service areas,the principles,influencing factors and its assignment cri-teria of service area classification are determined.The service areas are divided into three categories,namely Category A for hazardous chemical vehicles parking,category B only offering hazardous chemical vehicles water or oil and category C is prohibited for hazardous chemical vehicles driving into.The cluster analysis method is used to divide the pilot service areas into similar class,and the parking saturation level is used for determining the type properties of various types of service areas.%从安全性角度出发,根据危化品运输车辆的需求特性、服务区整体功能性,确定服务区划分的原则、影响因素及其赋值标准,将服务区划分为三大类,分别为 A 类可供危化品车辆停放的服务区,B 类仅提供加油加水的服务区和 C 类禁止危化品车辆驶入的服务区。并运用聚类分析方法将试点服务区划分相似的类,最后通过停车饱和度指标的高低判定各类服务区的类型属性。

  6. Hand Safety

    Science.gov (United States)

    ... Gardening Safety Turkey Carving Removing a Ring Español Artritis de la base del pulgar Dedo en gatillo ... Gardening Safety Turkey Carving Removing a Ring Español Artritis de la base del pulgar Dedo en gatillo ...

  7. Water Safety

    Science.gov (United States)

    ... Old Feeding Your 1- to 2-Year-Old Water Safety KidsHealth > For Parents > Water Safety Print A ... best measure of protection. previous continue Making Kids Water Wise It's important to teach your kids proper ...

  8. SAFETY FIRST

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Ensuring safety while peacefully utilizing nuclear energy is a top priority for China A fter a recent earthquake in Japan caused radioactive leaks at a nuclear power plant in Tokyo, the safety of nuclear energy has again aroused public attention.

  9. Safety Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Swan Lake National Wildlife Refuge Safety Plan discusses policies for the safety of the station employees, volunteers, and public. This plan seeks to identify...

  10. Algoritmos genéticos y modelos multivariados recursivos en la predicción de índices bursátiles de América del Norte: IPC, TSE, Nasdaq y DJI

    Directory of Open Access Journals (Sweden)

    Antonino Parisi

    2004-01-01

    Full Text Available Con valores de cierre semanales, correspondientes al periodo del 7 de abril de 1998 al 14 de abril de 2003, analizamos la eficiencia de los modelos multivariados dinámicos, elaborados a partir de algoritmos genéticos recursivos,para predecir el signo de las variaciones semanales de los índices bursátiles IPC, TSE, Nasdaq y DJI. Los resultados fueron comparados con los de un modelo AR(1 y de un modelo multivariado elaborado de manera aleatoria. Los mejores modelos producidos por el algoritmo genético obtienen un porcentaje de predicción de signo (PPS de 59, 60, 59 y 59%, para los índices IPC,Nasdaq, TSE y DJI, respectivamente. La capacidad predictiva resultó significativa en cada uno de los índices, de acuerdo con la prueba de acierto direccional de Peseran y Timmer man (1992. Al analizar el PPS de los modelos AR(1 se encontró que éstos fueron menores, resultando significativos únicamente en el caso del Nasdaq. Los modelos multivariados dinámicos elaborados de manera aleatoria presentaron el PPS más bajo (excepto en el índice TSE, siendo significativo para el Nasdaq sólo al considerar una significación de 10%. Además, los modelos elaborados por el algoritmo genético generaron el mayor rendimiento acumulado, excepto en el caso del Nasdaq, en el que la rentabilidad más alta fue obtenida por el modelo AR(1. Al efectuar una prueba de solidez por medio del análisis de mil series bootstrap se observó que, en promedio, el PPS fue de 51, 53, 49 y 53%, para los índices DJI, IPC, Na sdaq y TSE, respectivamente. Pese a ello los modelos multivariados superaron el rendimiento de una estrategia buy and hold en 57, 59 y 71% de los casos de los índices DJI, IPC y TSE, respectivamente. En el Nasdaq la frecuencia con que el modelo multivariado superó en rentabilidad a la estrategia pasiva fue de 41 por ciento.

  11. Algoritmos genéticos y modelos multivariados recursivos en la predicción de índices bursátiles de América del Norte: IPC, TSE, Nasdaq y DJI

    OpenAIRE

    Antonino Parisi; Franco Parisi; Edinson Cornejo

    2004-01-01

    Con valores de cierre semanales, correspondientes al periodo del 7 de abril de 1998 al 14 de abril de 2003, analizamos la eficiencia de los modelos multivariados dinámicos, elaborados a partir de algoritmos genéticos recursivos,para predecir el signo de las variaciones semanales de los índices bursátiles IPC, TSE, Nasdaq y DJI. Los resultados fueron comparados con los de un modelo AR(1) y de un modelo multivariado elaborado de manera aleatoria. Los mejores modelos producidos por el algo...

  12. Una propuesta para hacer más eficiente el IPC de la BMV. Un modelo con reversión a la media para la flotación relativa

    OpenAIRE

    Salvador Cruz Aké; Reyna Susana García Ruiz; Francisco Venegas-Martínez

    2013-01-01

    En este trabajo se desarrollan dos propuestas metodológicas para el cálculo del factor de flotación del índice de precios y cotizaciones (ipc) de la Bolsa Mexicana de Valores (bmv). La primera supone que el factor de flotación (free float factor) es aproximado mediante la normalización de la flotación diaria de cada tí- tulo, mientras que la segunda usa la flotación relativa diaria del mercado. En ambos casos, el factor de flotación es simulado mediante una variable con rever- sión a la media...

  13. Diastereo- and enantioselective synthesis of (E)-2-Methyl-1,2-syn- and (E)-2-Methyl-1,2-anti-3-pentenediols via allenylboronate kinetic resolution with ((d)Ipc)2BH and aldehyde allylboration.

    Science.gov (United States)

    Han, Jeng-Liang; Chen, Ming; Roush, William R

    2012-06-15

    Enantioselective hydroboration of racemic allenylboronate (±)-1 with 0.48 equiv of ((d)Ipc)(2)BH at -25 °C proceeds with efficient kinetic resolution and provides allylborane (R)-Z-4. When heated to 95 °C, allylborane (R)-Z-4 isomerizes to the thermodynamically more stable allylborane isomer (S)-E-7. Subsequent allylboration of aldehydes with (R)-Z-4 or (S)-E-7 at -78 °C followed by oxidative workup provides 1,2-syn- or 1,2-anti-diols, 2 or 3, respectively, in 87-94% ee.

  14. Safety assessment of smoke flavouring primary products by the European Food Safety Authority

    NARCIS (Netherlands)

    Theobald, A.; Arcella, D.; Carere, A.; Croera, C.; Engel, K.H.; Gott, D.; Gurtler, R.; Meier, D.; Pratt, I.; Rietjens, I.M.C.M.; Simon, R.; Walker, R.

    2012-01-01

    This paper summarises the safety assessments of eleven smoke flavouring primary products evaluated by the European Food Safety Authority (EFSA). Data on chemical composition, content of polyaromatic hydrocarbons and results of genotoxicity tests and subchronic toxicity studies are presented and

  15. Revising REACH guidance on information requirements and chemical safety assessment for engineered nanomaterials for aquatic ecotoxicity endpoints: recommendations from the EnvNano project

    DEFF Research Database (Denmark)

    Hansen, Steffen Foss; Sørensen, Sara Nørgaard; Skjolding, Lars Michael

    2017-01-01

    in solution”. The aim of this paper is to present the findings of the EnvNano project and through these provide the scientific background for specific recommendations on how ECHA guidance could be further improved. Key EnvNano findings such as the need to characterize dispersion and dissolution rates in stock...... be made applicable to nanomaterials. European Research Council project EnvNano—Environmental Effects and Risk Evaluation of Engineered, which ran from 2011 to 2016, took another outset by assuming that: “The behaviour of nanoparticles in suspension is fundamentally different from that of chemicals...

  16. 港口危险化学品项目安全设施设计专篇编制要点分析%Points analysis for compilation of safety facilities designed monographs in port hazardous chemicals project

    Institute of Scientific and Technical Information of China (English)

    韩刚; 龚庆文; 赵秀慧

    2014-01-01

    以天津浮式LNG接收终端项目(一期)码头工程为依托,从安全设施设计专篇的前期准备工作、编制内容及专篇审查各环节进行逐一论述,使设计人员对此类设计专篇的工作有一个全面系统的了解,并为今后危险化学品码头工程安全设施设计专篇的编制提供借鉴。%Taking Tianjin floating LNG receiving terminal project (Phase I) wharf engineering as the basis, we discussed the preparatory work, monographs content and monographs reviewing of safety facilities designed monographs to allow designers to have a comprehensive and systematic understanding of such designs, which can provide a reference for the future work of dan-gerous chemicals wharf engineering safety facilities designed monographs.

  17. Chemical Reactivity Test (CRT)

    Energy Technology Data Exchange (ETDEWEB)

    Zaka, F. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-12-13

    The Chemical Reactivity Test (CRT) is used to determine the thermal stability of High Explosives (HEs) and chemical compatibility between (HEs) and alien materials. The CRT is one of the small-scale safety tests performed on HE at the High Explosives Applications Facility (HEAF).

  18. Including non-dietary sources into an exposure assessment of the European Food Safety Authority: The challenge of multi-sector chemicals such as Bisphenol A.

    Science.gov (United States)

    von Goetz, N; Pirow, R; Hart, A; Bradley, E; Poças, F; Arcella, D; Lillegard, I T L; Simoneau, C; van Engelen, J; Husoy, T; Theobald, A; Leclercq, C

    2017-02-07

    In the most recent risk assessment for Bisphenol A for the first time a multi-route aggregate exposure assessment was conducted by the European Food Safety Authority. This assessment includes exposure via dietary sources, and also contributions of the most important non-dietary sources. Both average and high aggregate exposure were calculated by source-to-dose modeling (forward calculation) for different age groups and compared with estimates based on urinary biomonitoring data (backward calculation). The aggregate exposure estimates obtained by forward and backward modeling are in the same order of magnitude, with forward modeling yielding higher estimates associated with larger uncertainty. Yet, only forward modeling can indicate the relative contribution of different sources. Dietary exposure, especially via canned food, appears to be the most important exposure source and, based on the central aggregate exposure estimates, contributes around 90% to internal exposure to total (conjugated plus unconjugated) BPA. Dermal exposure via thermal paper and to a lesser extent via cosmetic products may contribute around 10% for some age groups. The uncertainty around these estimates is considerable, but since after dermal absorption a first-pass metabolism of BPA by conjugation is lacking, dermal sources may be of equal or even higher toxicological relevance than dietary sources.

  19. Public infrastructure disparities and the microbiological and chemical safety of drinking and surface water supplies in a community bordering a landfill.

    Science.gov (United States)

    Heaney, Christopher D; Wing, Steve; Wilson, Sacoby M; Campbell, Robert L; Caldwell, David; Hopkins, Barbara; O'Shea, Shannon; Yeatts, Karin

    2013-06-01

    The historically African-American Rogers-Eubanks community straddles unincorporated boundaries of two municipalities in Orange County, North Carolina, and predates a regional landfill sited along its border in 1972. Community members from the Rogers-Eubanks Neighborhood Association (RENA), concerned about deterioration of private wells and septic systems and a lack of public drinking water and sewer services, implemented a community-driven research partnership with university scientists and community-based organizations to investigate water and sewer infrastructure disparities and the safety of drinking and surface water supplies. RENA drafted memoranda of agreement with partners and trained community monitors to collect data (inventory households, map water and sewer infrastructure, administer household water and sewer infrastructure surveys, and collect drinking and surface water samples). Respondents to the surveys reported pervasive signs of well vulnerability (100%) and septic system failure (68%). Each 100-m increase in distance from the landfill was associated with a 600 most probable number/100 mL decrease in enterococci concentrations in surface water (95% confidence interval = -1106, -93). Pervasive private household water and sewer infrastructure failures and poor water quality were identified in this community bordering a regional landfill, providing evidence of a need for improved water and sanitation services.

  20. National Safety Council

    Science.gov (United States)

    ... Defensive Driving Workplace Training NSC University International Knowledge Knowledge Introduction Safety at Home Safety at Work Safety on ... or contact us . Measure Measure Safety Measure Safety Introduction Safety Management Systems Workplace Safety Consulting Employee Perception Surveys Research ...

  1. Study of the chemical interaction between the beryllium powders of different particles size and the air in the temperature range 500-1000degC form the viewpoint of ITER safety

    Energy Technology Data Exchange (ETDEWEB)

    Davydov, D.A. [State Scientific Center of Russian Federation, Moscow (Russian Federation); Konovalov, Y.V.; Gorokhov, V.A.; Levin, V.B.; Chekhlatov, G.M.; Khomutov, A.M.

    1998-01-01

    Under an effect of some factors characteristic for the ITER- operating condition a dense beryllium facing plasma can transit into various forms, changing its structural states. As a result of the bombardment of beryllium plasma facing components by ion fluxes, the production of a dust including the particles from a few micrometers to a few millimeters in size is possible. The specific features in the behaviour of various beryllium forms under emergency conditions are of an essential interest from the viewpoint of ITER safety. Some grades of powders of different average particles size (14-31 micron) have been produced in a given study, and their chemical interaction at high temperatures with air (500-1100degC), test duration effects simulating the emergency situation at ITER in the first approximation have been studied. The temperature dependence of beryllium powders (different particles size after disc abrased) interaction with air in the temperature range 500-1000degC at the exposure of 5 hours long for each temperature and kinetic dependence of interaction of these powders with air at 800degC for the exposure from half an hour to 7 hours long were studied. An analysis of granulometric weight fraction in the metallic and oxidized beryllium powders with different particles size has been done by the photosedimentational technique with the instrument `Analysette-20`. Construction of a mathematical model for the chemical interaction of beryllium powders with air at high temperatures have been carried out. (author)

  2. Safety; Avertissement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This annual report of the Senior Inspector for the Nuclear Safety, analyses the nuclear safety at EDF for the year 1999 and proposes twelve subjects of consideration to progress. Five technical documents are also provided and discussed concerning the nuclear power plants maintenance and safety (thermal fatigue, vibration fatigue, assisted control and instrumentation of the N4 bearing, 1300 MW reactors containment and time of life of power plants). (A.L.B.)

  3. Visit safety

    CERN Multimedia

    2012-01-01

    Experiment areas, offices, workshops: it is possible to have co-workers or friends visit these places.     You already know about the official visits service, the VIP office, and professional visits. But do you know about the safety instruction GSI-OHS1, “Visits on the CERN site”? This is a mandatory General Safety Instruction that was created to assist you in ensuring safety for all your visits, whatever their nature—especially those that are non-official. Questions? The HSE Unit will be happy to answer them. Write to safety-general@cern.ch.   The HSE Unit

  4. Medication safety.

    Science.gov (United States)

    Keohane, Carol A; Bates, David W

    2008-03-01

    Patient safety is a state of mind, not a technology. The technologies used in the medical setting represent tools that must be properly designed, used well, and assessed on an on-going basis. Moreover, in all settings, building a culture of safety is pivotal for improving safety, and many nontechnologic approaches, such as medication reconciliation and teaching patients about their medications, are also essential. This article addresses the topic of medication safety and examines specific strategies being used to decrease the incidence of medication errors across various clinical settings.

  5. Long-term Safety Observations on Side Effects and Complications of Non-surgical Sterilization by Chemical Instillation of the Fallopian Tubal

    Institute of Scientific and Technical Information of China (English)

    刘云嵘; 吴裕浩; 陈学煌; 黄真嘉; 徐铎; 蔡光宗

    1999-01-01

    The present objective is to observe the side effects and complications of female tubal sterilization by phenol-atabrine paste(PAP)and phenol mucilage(PM).1705 eligible women were divided randomly into two groups,871 usinig PAP and 834 women using PM.Results:The fever rates were 8.0% and 4.4%(P<0.01) respec-tively in group PAP and group PM.Infection rates of the appendages were 2.3‰ and 1.2‰ respectively.The incidence of chemical peritonitis,within the limits of pelvic cavity,were 1. 1‰ and 2.4‰ respectively.Perforation of uterus,pelvic ab-scess and ectopic pregnancy were not found during this observation.Slight abdominal pain after the procedures were 33.6% and 30.8% respectively.Slight vaginal bleed-ing after the procedure was 23.2% and 18.0% respectively.Menstruation of the women was not affected by the instillation.This five-year follow-up study neithershowed a positive Pap test nor a potential desease caused by the sterilizing agents.This technique is a safe and efficient method for female sterilization.

  6. Safety profile assessment and efficacy of chemically characterized Cinnamomum glaucescens essential oil against storage fungi, insect, aflatoxin secretion and as antioxidant.

    Science.gov (United States)

    Prakash, Bhanu; Singh, Priyanka; Yadav, Shilpee; Singh, S C; Dubey, N K

    2013-03-01

    The study explores the efficacy of Cinnamomum glaucescens essential oil (EO) as insecticidal, antifungal, antiaflatoxin and antioxidant agent so as to recommend its application as plant based preservatives for food commodities. The study reports the chemical characterization of C. glaucescens oil and its 100% insecticidal activity against insect pest Callosobruchus chinensis on 12 h exposure and 98.74% oviposition deterrency at 0.15 μl/ml. The EO significantly inhibited growth and aflatoxin production by toxigenic strain of Aspergillus flavus LHP-10 at 4.5 and 3.5 μl/ml respectively. EO also showed appreciable antioxidant activity (IC(50) value=15.1 μl/ml), non phytotoxic nature on chickpea seed germination and in vivo potential as fumigant in food system providing 71.07% protection of chickpea samples from fungal contamination and 100% antifeedant activity against the insect invasion. The EO exhibited non-mammalian toxicity showing high LD(50) (3971.34 μl/kg) during oral toxicity on mice.

  7. 10. colloquium on aspects of chemical and physical safety engineering. Current trends in safety engineering - research findings and legal boundary conditions - new options for large-scale experiments; 10. Kolloquium zu Fragen der chemischen und physikalischen Sicherheitstechnik. Aktuelle Entwicklungen in der Sicherheitstechnik - Forschungsergebnisse und gesetzliches Umfeld - neue Moeglichkeiten fuer Grossversuche

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    Since 1981, BAM and PTB have been hosting of this series of colloquia, at which attendants were informed on current news and trends in chemical and physical safety engineering. This volume informs on explosion protection to prevent formation of explosive solvent/vapour/air mixtures in dryers, ignition source safety of ga/air, dust/air, and dust layers, sudden ignition processes in hydrogen/air mixtures, test methods, influencing parameters of the hazardous properties of ammonium nitrate and materials containing it, fire behaviour and fire hazards of bulk goods and specific materials, problems in the application of new technical rules and directives on a national and European level, and new approaches to probabilistic risk assessment for safe design of gas stores. At this anniversary meeting, the attendants were also given the opportunity to visit the BAM test facilities at Horstwalde, about 50 km south of Berlin. This test site, with an area of 12 km{sup 2}, has an explosion test area with a diameter of 400 m for fire and explosion tests up to 150 kg TNT. (orig.)

  8. Seminar series on Safety matters

    CERN Multimedia

    HSE

    2010-01-01

    The HSE - Occupational Health & Safety and Environmental Protection - Unit is starting a seminar series on Safety matters. The aim is to invite colleagues from Universities, Industries or Government Agencies to share their experience. The seminars will take place in intervals of several months. Part of the Seminars will be held in the form of a Forum where participants can discuss and share views with persons who manage, teach or research Safety matters elsewhere. You are invited to the first Safety Seminar on 22nd September 2010 at 10h00 in building 40 S2 A1 "Salle Andersson" L’Ecole Polytechnique Fédérale de Lausanne (EPFL) will present the way safety is managed in their research institution. Some aspects of research in physics and chemical laboratories will also be presented. The seminar will be given by Dr Thierry Meyer, Head of OHS at FSB-EPFL and Dr Amela Groso, responsible for the safety of the physics institutes

  9. Eficiencia financiera del índice IPC mexicano a la luz de su impacto en la competitividad de las sociedades de inversión y ETF’s que lo replican en su política de inversión

    Directory of Open Access Journals (Sweden)

    Martínez Torre-Enciso, María Isabel

    2013-01-01

    Full Text Available El presente artículo prueba la propiedad de eficiencia financiera del índice IPC (como aproximación de la cartera del mercado bursátil mexicanoal utilizar el estadístico de prueba propuesto por Kandel y Stambaugh en dos simulaciones de eventos discretos, una con datos muestrales y otra con datos remuestreados con bootstraping. Los resultados sugieren que, a pesar de que la propiedad estudiada se mantiene en términos estadísticos, la proporción de fechas cuestiona la utilidad práctica del IPC, sugiriendo la necesidad de pruebas más robustas.

  10. Safety Systems

    Science.gov (United States)

    Halligan, Tom

    2009-01-01

    Colleges across the country are rising to the task by implementing safety programs, response strategies, and technologies intended to create a secure environment for teachers and students. Whether it is preparing and responding to a natural disaster, health emergency, or act of violence, more schools are making campus safety a top priority. At…

  11. Safety Instructions

    CERN Multimedia

    2003-01-01

    Please note that the Safety Instructions N0 37 rev. 3 (IS 37 rev. 3) entitled ""LEVEL-3" SAFETY ALARMS AND ALARM SYSTEMS" Is available on the web at the following URL: http://edms.cern.ch/document/335802 Paper copies can also be obtained from the TIS divisional secretariat, e-mail: tis.secretariat@cern.ch TIS Secretariat

  12. Study of safety and effectiveness of traditional dosage forms of the seed of Aristolochia elegans Mast. against malaria and laboratory investigation of pharmaco-toxicological properties and chemical constituents of its crude extracts

    Directory of Open Access Journals (Sweden)

    Yilkal Belay

    2011-01-01

    Full Text Available Background: Local communities in tropical regions, mainly in Africa, have used traditional herbal medicines as means of preventing and treating malaria with unrealistic experimental analysis. Aims: The safety and effectiveness of traditional dosage forms of dried seed of Aristolochia elegans mast. Was therefore assessed on 20 respondents who had been using the seed of this medicinal plant for over 1-2 years against malaria. Toxicological and pharmacological properties of ethanol and ether crude extracts of dried seed were also examined on 45 male Balb c mice. Materials and Methods: The methods used were personal interview schedule to assess safety and effectiveness of traditional dosage, evaluation of documented information, extraction of test medicinal substance, investigation of pharmaco-toxicological properties and qualitative chemical analysis. Statistical analysis was performed using data master sheets and scientific calculator. Results: The effectiveness of this seed was highly encouraging against malaria as compared to conventional antimalarial drugs. According to the respondents, relapse of malaria could usually happen with the conventional antimalarial drugs at normal doses, whereas relapse of malaria was rarely happening with the seed of A. elegans at the traditional dose taken. There were no health disorders discovered in 20 respondents who had been using the seed of this medicinal plant for over 1-2 years against malaria. However, laboratory mice died with a single dose of crude extracts at 1000-5000 mg/kg within 4-9 days after the dose was given orally. Histopathological examination showed that both crude extracts caused severe damage to the kidney and liver of Balb c mice. Four out of 10 treated Balb c mice also developed hemorrhages in the stomach, which was a strong indication of carcinogenic property of this plant material. Conclusion: A person using this herbal preparation is therefore at a higher risk of getting stomach cancer

  13. Chemically characterized Mentha cardiaca L. essential oil as plant based preservative in view of efficacy against biodeteriorating fungi of dry fruits, aflatoxin secretion, lipid peroxidation and safety profile assessment.

    Science.gov (United States)

    Dwivedy, Abhishek Kumar; Prakash, Bhanu; Chanotiya, Chandan Singh; Bisht, Deepa; Dubey, Nawal Kishore

    2017-08-01

    The study reports Mentha cardiaca essential oil (EO) as plant based preservative against fungal and aflatoxin contamination of stored dry fruits. Mycoflora analysis of the dry fruits revealed Aspergillus favus LHP-PV-1 as the most aflatoxigenic isolate with highest Aflatoxin B1 content. M. cardiaca EO showed broad fungitoxic spectrum inhibiting the tested moulds contaminating dry fruits. It's minimum inhibitory concentration (MIC), minimum aflatoxin inhibitory concentration (MAIC) and minimum fungicidal concentration (MFC) against A. favus LHP-PV-1 were recorded to be 1.25, 1.0 and 2.25 µL/mL respectively. The EO caused decrease in ergosterol content and enhanced leakage of Ca(2+), K(+) and Mg(2+) ions from treated fungal cells, depicting fungal plasma membrane as the site of antifungal action. The EO showed promising DPPH free radical scavenging activity (IC50 value:15.89 µL/mL) and favourable safety profile with LD50 value (7133.70 mg/kg body wt.) when estimated through acute oral toxicity on mice. Carvone (61.62%) was recorded as the major component of the oil during chemical characterisation through GC-MS. Based on strong antifungal, antiaflatoxigenic and antioxidant potential, the chemically characterised M. cardiaca EO may be recommended as safe plant based preservative and shelf life enhancer of food items. This is the first report on antifungal and antiaflatoxigenic activity of M. cardiaca EO. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Delayed IPC exerts cardioprotective effect through neovascularization in a rodent permanent occlusive coronary rat model%延迟缺血预处理对急性心肌梗死大鼠梗死边缘区中小动脉再生及梗死面积的影响

    Institute of Scientific and Technical Information of China (English)

    程劲松; 柯元南; 王慧; 吴文静; 孔炜; 郑金刚

    2011-01-01

    AIM: To investigate whether delayed ischemic preconditioning (IPC) exerts a cardioprotective effect through arteriogenesis in a rodent permanent occlusive coronary rat model. METHODS: Fifty four rats were randomly divided into four groups. In IPC +acute myocardial infarction (AMI) group (n =24),rat left anterior descending coronary arteries were ligated 24 h after IPC. In AMI group (n =24), rat left anterior descending coronary arteries were ligated without IPC. In IPC group ( n = 3 ), rats were subjected to IPC procedure and in sham group (n = 3 ), rats were not subjected to either IPC or ligation. At 3, 7,and 14 days, the heart sections of IPC + AMI group and AMI group rats were obtained to detect the capillary density and arteriole density by immunostaining. Heart function and infarct size were measured by Masson's trichrome staining and echocardiography in 14-day subgroup. At 24 h, the heart sections of IPC group and sham group were obtained to detect the capillary density and VEGF and PDGF-B expression.RESULTS: Neovascularization was seen in rat heart section 24 h after IPC. Compared with sham group,the expression of VEGF, PDGF-B in heart section in rats of IPC group increased significantly (P <0. 05). Compared with those in AMI group, capillary density and arteriole density in heart sections in rats of IPC +AMI group increased in 3-, 7- and 14-day subgroups (P <0. 05). Infarct size was reduced and heart function improved in 14-day subgroup (P < 0. 05 ). CONCLUSION: Delayed IPC reduces infarct size and improves heart function in a permanent occlusive rat model. This may result from increased functional arteriogenesis, whereas increased expression of VEGF, PDGF-B in heart section in rats of IPC group may contribute to proliferative arteriole.%目的:探讨延迟缺血预处理(delayed ischemic preconditioning,DIPC)对急性心肌梗死(AMI)大鼠远期的心肌保护及其促进小动脉再生的作用.方法:将54只SD大鼠随机分为4组,即①缺血预处理(IPC

  15. Nuclear Safety

    Energy Technology Data Exchange (ETDEWEB)

    Silver, E G [ed.

    1989-01-01

    This document is a review journal that covers significant developments in the field of nuclear safety. Its scope includes the analysis and control of hazards associated with nuclear energy, operations involving fissionable materials, and the products of nuclear fission and their effects on the environment. Primary emphasis is on safety in reactor design, construction, and operation; however, the safety aspects of the entire fuel cycle, including fuel fabrication, spent-fuel processing, nuclear waste disposal, handling of radioisotopes, and environmental effects of these operations, are also treated.

  16. Status of chemistry lab safety in Nepal.

    Science.gov (United States)

    Kandel, Krishna Prasad; Neupane, Bhanu Bhakta; Giri, Basant

    2017-01-01

    Chemistry labs can become a dangerous environment for students as the lab exercises involve hazardous chemicals, glassware, and equipment. Approximately one hundred thousand students take chemistry laboratory classes annually in Nepal. We conducted a survey on chemical lab safety issues across Nepal. In this paper, we assess the safety policy and equipment, protocols and procedures followed, and waste disposal in chemistry teaching labs. Significant population of the respondents believed that there is no monitoring of the lab safety in their lab (p<0.001). Even though many labs do not allow food and beverages inside lab and have first aid kits, they lack some basic safety equipment. There is no institutional mechanism to dispose lab waste and chemical waste is disposed haphazardly. Majority of the respondents believed that the safety training should be a part of educational training (p = 0.001) and they would benefit from short course and/or workshop on lab safety (p<0.001).

  17. 基于IPC方案的铝塑铝泡罩包装机电控系统研究%Research for IPC Control System in The Thermoform Machine UPS4 ETX

    Institute of Scientific and Technical Information of China (English)

    吴主峰; 冯雄裕; 马文喜

    2016-01-01

    利用BECKHOFF IPC(工业控制计算机)的控制技术,对UPS4铝塑铝泡罩包装机电控系统进行整体研究并进行现场升级改造,新系统运行结果表明,该控制系统可大大提高铝塑铝UPS4泡罩包装机整体的稳定性和可操作性。%Use BECKHOFF IPC control technique to restruct the control system of the thermoform machine UPS4 ETX. The result shows that after restruting,the new control system can greatly improve the stability and operability of the thermoform machine UPS4 ETX.

  18. Safety Training: places available in October 2014

    CERN Multimedia

    2014-01-01

    There are places available in the forthcoming Safety courses. For updates and registrations, please refer to the Safety Training Catalogue. Safety Training, HSE Unit safety-training@cern.ch Title of the course EN Title of the course FR Date Hours Language Chemical Safety ATEX Habilitation - Level 2 Habilitation ATEX - Niveau 2 16-Oct-14 to 17-Oct-14 9:00 - 17:30 French Cryogenic Safety Cryogenic Safety - Fundamentals Sécurité Cryogénie - Fondamentaux 23-Oct-14 10:00 - 12:00 English Cryogenic Safety - Helium Transfer Sécurité Cryogénie - Transfert d'hélium 30-Oct-14 9:30 - 12:00 English Electrical Safety Habilitation Electrique - Electrician Low Voltage - Initial Habilitation électrique - Électricien basse tension - Initial 02-Oct-14 to 06-Oct-14 9:00 - 17:30 English 20-Oct-14 to 22-Oct-14 9:00 -...

  19. Building Programs Seminar of Hazardous Chemicals Transportation Safety Services Platform%危化品运输安全服务平台的建设方案研讨

    Institute of Scientific and Technical Information of China (English)

    谢枭

    2011-01-01

    为了提高危化品运输的安全服务水平,本文提出了危化品运输安全服务系统建设思路,研究了建设集中的大型危化品运输安全服务平台的设计方案,从而为企业和政府监管单位设计和建设大型危化品公路运输安全服务平台提供了参考。%In order to improve the safety of hazardous goods transport services,this paper presents a hazardous material transportation security service system building ideas,study focused on the construction of large-scale hazardous material transportation security services platform design, so as to corporate and government regulatory units design and construction of large-scale road transport of hazardous chemicals to provide a reference platform security services.

  20. Home Safety

    Science.gov (United States)

    ... October 2015) Preventing accidental injuries to children in India. Video Changing the News with Neal McDonough: Fire ... Our Mailing List Global Road Safety Sponsors Recalls Media Center Blog Videos Newsletter facebook twitter instagram pinterest ...

  1. Safety first!

    CERN Multimedia

    2016-01-01

    Among the many duties I assumed at the beginning of the year was the ultimate responsibility for Safety at CERN: the responsibility for the physical safety of the personnel, the responsibility for the safe operation of the facilities, and the responsibility to ensure that CERN acts in accordance with the highest standards of radiation and environmental protection.   The Safety Policy document drawn up in September 2014 is an excellent basis for the implementation of Safety in all areas of CERN’s work. I am happy to commit during my mandate to help meet its objectives, not least by ensuring the Organization makes available the necessary means to achieve its Safety objectives. One of the main objectives of the HSE (Occupational Health and Safety and Environmental Protection) unit in the coming months is to enhance the measures to minimise CERN’s impact on the environment. I believe CERN should become a role model for an environmentally-aware scientific research laboratory. Risk ...

  2. Relationship of safety culture and process safety

    Energy Technology Data Exchange (ETDEWEB)

    Olive, Claire [Mary Kay O' Connor Process Safety Center, Chemical Engineering Department, Texas A and M University System, College Station, TX 77843-3122 (United States); O' Connor, T. Michael [Mary Kay O' Connor Process Safety Center, Chemical Engineering Department, Texas A and M University System, College Station, TX 77843-3122 (United States); Mannan, M. Sam [Mary Kay O' Connor Process Safety Center, Chemical Engineering Department, Texas A and M University System, College Station, TX 77843-3122 (United States)]. E-mail: mannan@tamu.edu

    2006-03-17

    Throughout history, humans have gathered in groups for social, religious, and industrial purposes. As the conglomeration of people interact, a set of underlying values, beliefs, and principles begins to develop that serve to guide behavior within the group. These 'guidelines' are commonly referred to as the group culture. Modern-day organizations, including corporations, have developed their own unique cultures derived from the diversity of the organizational interests and the background of the employees. Safety culture, a sub-set of organizational culture, has been a major focus in recent years. This is especially true in the chemical industry due to the series of preventable, safety-related disasters that occurred in the late seventies and eighties. Some of the most notable disasters, during this time period, occurred at Bhopal, Flixborough, and Seveso. However, current events, like the September 11th terrorist attacks and the disintegration of the Columbia shuttle, have caused an assessment of safety culture in a variety of other organizations.

  3. 76 FR 48093 - Hazardous Chemical Reporting: Revisions to the Emergency and Hazardous Chemical Inventory Forms...

    Science.gov (United States)

    2011-08-08

    ... required to prepare or have available a material safety data sheet (MSDS) for a hazardous chemical defined... facility owner or operator is required to submit a MSDS or a list that contains the hazardous chemical... the Material Safety Data Sheet (MSDS) and provide the Chemical Abstract Service (CAS) registry number...

  4. Sustainable Development of Food Safety

    DEFF Research Database (Denmark)

    Fabech, B.; Georgsson, F.; Gry, Jørn

    to food safety - Strengthen efforts against zoonoses and pathogenic microorganisms - Strengthen safe food handling and food production in industry and with consumers - Restrict the occurrence of chemical contaminants and ensure that only well-examined production aids, food additives and flavours are used...... - Strengthen scientific knowledge of food safety - Strengthen consumer knowledge The goals for sustainable development of food safety are listed from farm to fork". All of the steps and areas are important for food safety and consumer protection. Initiatives are needed in all areas. Many of the goals...... in other areas. It should be emphasized that an indicator will be an excellent tool to assess the efficacy of initiatives started to achieve a goal. Conclusions from the project are: - Sustainable development in food safety is important for humanity - Focus on the crucial goals would optimize the efforts...

  5. Chemical thermodynamics of technetium

    Energy Technology Data Exchange (ETDEWEB)

    Amaia Sandino, M.C.; Oesthols, E. [eds.] [OECD Nuclear Energy Agency NEA, Issy-les-Moulineaux (France)

    1999-07-01

    This volume on technetium is the third volume in a series of critical reviews of the chemical thermodynamic properties of elements of special importance to modelling efforts for the safety assessment of radioactive waste disposal systems, and is the only one concerned with a fission product element. The first two volumes were reviews of the chemical thermodynamics of uranium and americium. Thermochemical data for neptunium and plutonium are being reviewed for a later volume. refs.

  6. Safety in the Chemical Laboratory. Organic Peroxides.

    Science.gov (United States)

    Shanley, Edward S.

    1990-01-01

    Discussed is the thermodynamic instability of organic peroxides. The process of autoxidation which results in peroxide formation is described. Precautions necessary to prevent autoxidation hazards associated with these reagents are suggested. (CW)

  7. First Aid and Safety

    Science.gov (United States)

    ... Playground Safety Preventing Children's Sports Injuries Safety Tips: Baseball Safety Tips: Basketball Safety Tips: Hockey Safety Tips: ... it a Medical Emergency? Knowing Your Child's Medical History Nosebleeds Seizures Serious Allergic Reactions (Anaphylaxis) Teaching Your ...

  8. Chemical hygiene plan

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-01

    This plan was written to administer and monitor safety measures and chemical hygiene principles in the TAC Uranium Mill Tailing Remedial Action Project sample preparation facility in Albuquerque, New Mexico. It applies to toxic and/or hazardous materials to radioactive materials.

  9. Water Safety

    Science.gov (United States)

    ... Families International Services Who We Are Mission & Values History Governance Red Cross Stories Celebrity Supporters News & Events ... use. Alcohol impairs judgment, balance and coordination; affects swimming and diving skills; and ... and use barriers around your home pool or hot tub . Safety covers and pool alarms ...

  10. SAFETY BULLETIN

    CERN Multimedia

    TIS Secretariat

    2002-01-01

    Please note that the Safety Bulletin no 4 (TIS 2002-04) entitled 'KNOW THE RISKS' is available on the web. Paper copies can also be obtained from the TIS Divisional Secretariat, e-mail: TIS.Secretariat@cern.ch TIS Secretariat

  11. Online Safety.

    Science.gov (United States)

    Levine, Elliott

    2001-01-01

    Describes provisions of Children's Internet Protection Act, which school districts are required to implement on or before October 31, 2001, involving the development and public dissemination of federally mandated Internet-safety policy to prevent minors from accessing inappropriate and harmful material. Provides suggestions to protect children…

  12. Safety Resources.

    Science.gov (United States)

    Hoot, James L.; Bartkowiak, Elaine T.

    1994-01-01

    Lists 72 organizations and programs that deal with child safety, grouped by the following categories: (1) general; (2) general violence; (3) gun violence; (4) media violence; (5) drugs and alcohol; (6) child abuse and at-risk children; (7) parenting programs; (8) community service programs; (9) leadership programs; (10) peer counseling; (11)…

  13. National Institute for Occupational Safety and Health

    Science.gov (United States)

    ... Funding Training Resources NIOSH Newsroom NIOSH Science Blog Workplace Safety and Health Topics Hazards & Exposures Chemicals Emergency ... Contact BSC Registration for September 26, 2017 Meeting Diversity in NIOSH Goals Message Vision Grants & Funding Training ...

  14. Food Safety Assessment and Programming.

    Science.gov (United States)

    Gilmore, Gary D.; And Others

    1994-01-01

    A 1990 Wisconsin extension survey (n=1,549) was followed up in 1993 (n=1,135). In 1993, the top three concerns about food safety were food-borne illnesses, government role, and pesticides/chemicals; in 1990, they were pesticides, drugs in food, and manufacturing standards. In both surveys, preferred information sources were radio, television, and…

  15. Safety climate practice in Korean manufacturing industry

    Energy Technology Data Exchange (ETDEWEB)

    Baek, Jong-Bae [Department of Safety Engineering, Chungju National University, Chungju 380-702 (Korea, Republic of); Bae, Sejong [Department of Biostatistics, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 (United States)], E-mail: sbae@hsc.unt.edu; Ham, Byung-Ho [Department of Industrial Safety, Ministry of Labor (Korea, Republic of); Singh, Karan P. [Department of Biostatistics, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 (United States)

    2008-11-15

    Safety climate survey was sent to 642 plants in 2003 to explore safety climate practices in the Korean manufacturing plants, especially in hazardous chemical treating plants. Out of 642 plants contacted 195 (30.4%) participated in the surveys. Data were collected by e-mail using SQL-server and mail. The main objective of this study was to explore safety climate practices (level of safety climate and the underlying problems). In addition, the variables that may influence the level of safety climate among managers and workers were explored. The questionnaires developed by health and safety executive (HSE) in the UK were modified to incorporate differences in Korean culture. Eleven important factors were summarized. Internal reliability of these factors was validated. Number of employees in the company varied from less than 30 employees (9.2%) to over 1000 employees (37.4%). Both managers and workers showed generally high level of safety climate awareness. The major underlying problems identified were inadequate health and safety procedures/rules, pressure for production, and rule breaking. The length of employment was a significant contributing factor to the level of safety climate. In this study, participants showed generally high level of safety climate, and length of employment affected the differences in the level of safety climate. Managers' commitment to comply safety rules, procedures, and effective safety education and training are recommended.

  16. Patent Technology Competitor Group Analysis Method Based on IPC%基于专利IPC分类号的技术竞争对象的群组分析方法

    Institute of Scientific and Technical Information of China (English)

    韩红旗; 付媛; 朱礼军

    2015-01-01

    技术竞争对象群组是产业技术内的技术研发实体因为技术上接近而形成的集群。发现技术竞争对象群组,可以从较高层次上掌握产业技术领域内的竞争态势,给产业技术参与者和政策制定者提供有价值的情报信息。首先概述了主要的群组分析方法,然后引入了可视化的LinLog图形聚类分析方法,从研发机构、省份和国家三个层面,提出了以IPC分类号为特征的技术竞争对象群组的识别流程模型。采集了燃料电池技术领域的专利数据作为实验研究,对数据进行了预处理,采取提出的方法对该领域的竞争对象群组进行了识别,验证了该方法的有效性。%It is crucial to understand the technical groups of intra-industry and to master the competition in the field of technology. In order to provide valuable information to industry participants and policymakers, the Patent technology competitor group analysis method based on IPC is introduced. Firstly, the analysis method of groups is summarized. The recognition model of technological competitor groups characterized by the IPC classification number and the technical terms is put forward. Then, obtain patent data for this research in the field of fuel cell technology through multi-threaded Chinese patent data acquisition system. Finally, invoking LinLog visualization tools to do graphical clustering for research and development institutions, provinces and countries and the patent technology competitor analysis method is validated.

  17. Chemical Emergencies

    Science.gov (United States)

    When a hazardous chemical has been released, it may harm people's health. Chemical releases can be unintentional, as in the case of an ... the case of a terrorist attack with a chemical weapon. Some hazardous chemicals have been developed by ...

  18. Safety Note

    CERN Multimedia

    SC Secretariat

    2004-01-01

    Please note that the Safety Note no 29 (NS 29) entitled 'Fire Prevention for Insulating Core (Sandwich) Panel Structures for Inside Use Guidelines for Selection, Installation and Use' is available on the web at the following url: https://edms.cern.ch/document/475438/LAST_RELEASED Paper copies can also be obtained from the SC Unit secretariat, e-mail : sc.secretariat@cern.ch SC Secretariat

  19. Automatic Control System of Car Glass Hot Bending Furnace Based on IPC+PLC control%基于IPC+PLC控制的汽车玻璃热弯炉自动控制系统

    Institute of Scientific and Technical Information of China (English)

    程雪利; 董志军; 杨用增

    2013-01-01

    In this paper ,a set of automatic control system based on IPC + PLC control car glass hot bending furnace was designed ,this system can realize the function of furnace wire power control ,fur-nace silk elevator control ,configuration king 6 .52 and PLC communication ,furnace cover movable con-trol ,plunger elevator control ,heat preservation control ,configuration king file read and real -time de-tection glass temperature ,and the others ,through the overall monitoring system ,operation panel and display panel realization man-machine conversation .%  设计了一套基于IPC+ PLC控制的汽车玻璃热弯炉自动控制系统,该系统可以实现炉丝功率调节、炉丝自动升降、组态王6.52和PLC通讯、炉盖开合控制、顶杆升降控制、保温控制、玻璃工艺文件保存读取及红外线实时检测玻璃温度等功能,通过监控软件、操作面板和温度仪表等实现人机对话。

  20. Remanufacturing strategy for chemical equipment

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xian-cheng; XU Bin-shi; WANG Hai-dou; JIANG Yi; WU Yi-xiong; GONG Jian-ming; TU Shan-dong

    2005-01-01

    Failure, especially induced by cracks, usually occurred in the service process of chemical equipment, which could cause the medium leakage, fire hazard and explosion and induced the personnel casualty and economic losses. To assure the long-term and safety service, it is necessary to apply the remanufacturing technology on the chemical equipment containing cracks. The recent research advances on the remanufacturing, the failure modes and the life extension technology for chemical equipment were reviewed. The engineering strategy of the remanufacturing for the chemical equipment was proposed, which could provide a reasonable and reliable technical route for the remanufacturing operation of chemical equipment. In the strategy, the redesign was also been considered.

  1. A Product Safety Primer

    Science.gov (United States)

    Brown, Mary Anne Symons

    1975-01-01

    The article offers an overview of the product safety issue and offers ideas for helping students develop product safety awareness. The role of the Consumer Product Safety Commission and safety legislation are discussed. (MW)

  2. SAFETY NOTES

    CERN Document Server

    TIS Secretariat

    2001-01-01

    Please note that the revisions of safety notes no 3 (NS 3 Rev. 2) and no 24 (NS 24 REV.) entitled respectively 'FIRE PREVENTION FOR ENCLOSED SPACES IN LARGE HALLS' and 'REMOVING UNBURIED ELV AND LVA ELECTRIC CONDUITS' are available on the web at the following urls: http://edmsoraweb.cern.ch:8001/cedar/doc.download?document_id=322811&version=1&filename=version_francaise.pdf http://edmsoraweb.cern.ch:8001/cedar/doc.download?document_id=322861&version=2&filename=version_francaise.pdf Paper copies can also be obtained from the TIS Divisional Secretariat, email tis.secretariat@cern.ch

  3. Safety training

    CERN Multimedia

    SC Unit

    2009-01-01

    Habilitation électrique A course entitled "Habilitation électrique pour personnel de laboratoire" (electrical safety qualification for laboratory personnel) will be held on 22 and 23 June. Registration by e-mail to isabelle.cusato@cern.ch. Explosion Hazards in the handling of flammable solvents and gases A course entitled "Explosion Hazards in the handling of flammable solvents and gases" given in French will be held on 18-19 June 2009. This course is obligatory for all FGSOs at CERN, and it is recommended for anyone handling flammable gas or solvents. To sign up please visit this page. For more information please contact Isabelle Cusato, tel. 73811.

  4. Safety management of complex research operations

    Science.gov (United States)

    Brown, W. J.

    1981-01-01

    Complex research and technology operations present many varied potential hazards which must be addressed in a disciplined independent safety review and approval process. The research and technology effort at the Lewis Research Center is divided into programmatic areas of aeronautics, space and energy. Potential hazards vary from high energy fuels to hydrocarbon fuels, high pressure systems to high voltage systems, toxic chemicals to radioactive materials and high speed rotating machinery to high powered lasers. A Safety Permit System presently covers about 600 potentially hazardous operations. The Safety Management Program described in this paper is believed to be a major factor in maintaining an excellent safety record at the Lewis Research Center.

  5. Safety for Users

    CERN Document Server

    HR Department

    2008-01-01

    CERN welcomes more than 8000 Users every year. The PH Department as host to these scientific associates requires the highest safety standards. The PH Safety Office has published a Safety Flyer for Users. Important safety topics and procedures are presented. Although the Flyer is intended primarily to provide safety information for Users, the PH Safety Office invites all those on the CERN sites to keep a copy of the flyer as it gives guidance in matters of safety and explains what to do in the event of an emergency. Link: http://ph-dep.web.cern.ch/ph-dep/Safety/SafetyOffice.html PH-Safety Office PH Department

  6. Safety for Users

    CERN Document Server

    HR Department

    2008-01-01

    CERN welcomes more than 8000 Users every year. The PH Department as host to these scientific associates requires the highest safety standards. The PH Safety Office has published a safety flyer for Users. Important safety topics and procedures are presented. Although the flyer is intended primarily to provide safety information for Users, the PH Safety Office invites all those on the CERN sites to keep a copy of the flyer as it gives guidance in matters of safety and explains what to do in the event of an emergency. The flyer is available at: http://ph-dep.web.cern.ch/ph-dep/Safety/SafetyOffice.html PH-Safety Office PH Department

  7. Chemical Tracking Systems: Not Your Usual Global Positioning System!

    Science.gov (United States)

    Roy, Ken

    2007-01-01

    The haphazard storing and tracking of chemicals in the laboratory is a serious safety issue facing science teachers. To get control of your chemicals, try implementing a "chemical tracking system". A chemical tracking system (CTS) is a database of chemicals used in the laboratory. If implemented correctly, a CTS will reduce purchasing costs,…

  8. Safety first

    Energy Technology Data Exchange (ETDEWEB)

    Harvie, W.

    1997-06-01

    Expansion of international business opportunities for Canadian producers and service companies brings with it a dimension almost never considered on home base - security. It was pointed out that once abroad, safety and defence of people and equipment can become significant problems in many parts of the world. The nature of the security risks involved, and how best to deal with them, were discussed. The use of consultants, mostly foreign ones to date, and the kind of assistance they can provide, everything from written reports on the local situation to counter surveillance training, and bodyguard services, have been described. Examples of recent involvements with guerilla groups demanding `revolutionary war taxes`, kidnapping executives for ransom, due diligence investigations of potential partners, and the like, have been provided to illustrate the unique character of the problem, and the constant need for being alert, educated to risks, and being prepared to react to risk situations.

  9. Construction safety

    CERN Document Server

    Li, Rita Yi Man

    2013-01-01

    A close-to-ideal blend of suburb and city, speedy construction of towers of Babylon, the sparkling proportion of glass and steel buildings’ facade at night showcase the wisdom of humans. They also witness the footsteps, sweats and tears of architects and engineers. Unfortunately, these signatures of human civilizations are swathed in towering figures of construction accidents. Fretting about these on sites, different countries adopt different measures on sites. This book firstly sketches the construction accidents on sites, followed by a review on safety measures in some of the developing countries such as Bermuda, Egypt, Kuwait and China; as well as developed countries, for example, the United States, France and Singapore. It also highlights the enormous compensation costs with the courts’ experiences in the United Kingdom and Hong Kong.

  10. Physical and Chemical Properties and Safety Study of Six Corn Seed-coatings to Maize%6种玉米种衣剂的理化性质测定及其安全性研究

    Institute of Scientific and Technical Information of China (English)

    王斌; 张婧赢; 王岩; 郑逢云; 刘三明

    2011-01-01

    To better understand the quality of corn seed-coatings, physical and chemical properties and safety of six corn seed-coatings were tested.Film-forming, Coating homogeneity and suspension rate of all coatings met the national standards.Viscosity values of 15.5% Thiram · Carbofuran and 8.1% Carbofuran ·Tebuconazole· Triadimenfon reached the national standards.pH ranges of all seed coatings occurred between 6.38 and 7.55, and 25% Carbofuran· Thiram· Carboxin, 15% Thiram· Carbofuran· Tebuconazole and 20% Thiram· Carbofuran · Triadimenal came up to the National Standards.Pull-out rate of seed coatings met the national standards excerpt 25% Carbofuran· Thiram· Carboxin.Germination potential, germination rate,germination index, date of seedling vigor index, seedling length and fresh weight of seeds treated with seed coating were lower than the control in Laboratory.Seedling emergency rates of all treatments in field trail were improved comparing with the control, but seedling quality had no significant increase.The results showed that 15.5% Thiram· Carbofuran is the best choice among the six corn seed-coatings.%为了解市场上玉米种衣剂的质量,对6种市售玉米种衣剂的理化性质和安全性进行了测定.理化性质表明:6种种衣剂的成膜时间、包衣均匀度和悬浮率都符合国家标准;不同种衣剂粘度值差异显著,只有福·克和克·戊·三唑酮符合国家标准;pH都在6.83~7.55之间,其中克·福·萎、福·克·唑醇和克·醇·福美双符合国家标准;包衣脱落率只有克·福·萎大于10%,其它药剂均达到国家标准.室内发芽实验表明:经玉米种衣剂处理后,玉米种子活力等各项指标均低于对照;而田间实验表明:种衣剂处理后,玉米出苗率、幼苗素质与对照相比都有所提高,其中福·克效果最为显著.从室内、田间的实验结果分析,福·克是6种玉米种衣剂中的最佳选择.

  11. Effect of anti-glycosphingolipid monoclonal antibodies in pathogenic fungal growth and differentiation. Characterization of monoclonal antibody MEST-3 directed to Manpα1→3Manpα1→2IPC

    Directory of Open Access Journals (Sweden)

    Straus Anita H

    2010-02-01

    Full Text Available Abstract Background Studies carried out during the 1990's demonstrated the presence of fungal glycoinositol phosphorylceramides (GIPCs with unique structures, some of them showed reactivity with sera of patients with histoplasmosis, paracoccidioidomycosis or aspergillosis. It was also observed that fungal GIPCs were able to inhibit T lymphocyte proliferation "in vitro", and studies regarding the importance of these molecules to fungal survival showed that many species of fungi are vulnerable to inhibitors of sphingolipid biosynthesis. Results In this paper, we describe a detailed characterization of an IgG2a monoclonal antibody (mAb, termed MEST-3, directed to the Paracoccidioides brasiliensis glycolipid antigen Pb-2 (Manpα1→3Manpα1→2IPC. mAb MEST-3 also recognizes GIPCs bearing the same structure in other fungi. Studies performed on fungal cultures clearly showed the strong inhibitory activity of MEST-3 on differentiation and colony formation of Paracoccidioides brasiliensis, Histoplasma capsulatum and Sporothrix schenckii. Similar inhibitory results were observed when these fungi where incubated with a different mAb, which recognizes GIPCs bearing terminal residues of β-D-galactofuranose linked to mannose (mAb MEST-1. On the other hand, mAb MEST-2 specifically directed to fungal glucosylceramide (GlcCer was able to promote only a weak inhibition on fungal differentiation and colony formation. Conclusions These results strongly suggest that mAbs directed to specific glycosphingolipids are able to interfere on fungal growth and differentiation. Thus, studies on surface distribution of GIPCs in yeast and mycelium forms of fungi may yield valuable information regarding the relevance of glycosphingolipids in processes of fungal growth, morphological transition and infectivity.

  12. [Manufactured baby food: safety expectations].

    Science.gov (United States)

    Davin, L; Van Egroo, L-D; Galesne, N

    2010-12-01

    Food safety is a concern for parents of infants, and healthcare professionals are often questioned by them about this topic. Baby food European regulation ensures high levels of safety and is more rigorous than common food regulation. Maximal limit for pesticides in baby food demonstrates the high level of requirements. This limit must be below the 10 ppb detection threshold, whatever the chemical used. Other contaminants such as nitrates are also the subject of greater expectations in baby food. Food safety risks control needs a specific know-how that baby food manufacturers have acquired and experienced, more particularly by working with producers of high quality raw material. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  13. Linking Safety Analysis to Safety Requirements

    DEFF Research Database (Denmark)

    Hansen, Kirsten Mark

    the same system model and that this model is formalized in a real-time, interval logic, based on a conventional dynamic systems model with a state over time. The three safety analysis techniques are interpreted in this model and it is shown how to derive safety requirements for components of a system.......Software for safety critical systems must deal with the hazards identified by safety analysistechniques: Fault trees, event trees,and cause consequence diagrams can be interpreted as safety requirements and used in the design activity. We propose that the safety analysis and the system design use...

  14. CERN's new safety policy

    CERN Multimedia

    2014-01-01

    The documents below, published on 29 September 2014 on the HSE website, together replace the document SAPOCO 42 as well as Safety Codes A1, A5, A9, A10, which are no longer in force. As from the publication date of these documents any reference made to the document SAPOCO 42 or to Safety Codes A1, A5, A9 and A10 in contractual documents or CERN rules and regulations shall be deemed to constitute a reference to the corresponding provisions of the documents listed below.   "The CERN Safety Policy" "Safety Regulation SR-SO - Responsibilities and organisational structure in matters of Safety at CERN" "General Safety Instruction GSI-SO-1 - Departmental Safety Officer (DSO)" "General Safety Instruction GSI-SO-2 - Territorial Safety Officer (TSO)" "General Safety Instruction GSI-SO-3 - Safety Linkperson (SLP)" "General Safety Instruction GSI-SO-4 - Large Experiment Group Leader In Matters of Safety (LEXGLI...

  15. Fire safety

    Energy Technology Data Exchange (ETDEWEB)

    Keski-Rahkonen, O.; Bjoerkman, J.; Hostikka, S.; Mangs, J. [VTT Building Technology, Espoo (Finland); Huhtanen, R. [VTT Energy, Espoo (Finland); Palmen, H.; Salminen, A.; Turtola, A. [VTT Automation, Espoo (Finland)

    1998-07-01

    According to experience and probabilistic risk assessments, fires present a significant hazard in a nuclear power plant. Fires may be initial events for accidents or affect safety systems planned to prevent accidents and to mitigate their consequences. The project consists of theoretical work, experiments and simulations aiming to increase the fire safety at nuclear power plants. The project has four target areas: (1) to produce validated models for numerical simulation programmes, (2) to produce new information on the behavior of equipment in case of fire, (3) to study applicability of new active fire protecting systems in nuclear power plants, and (4) to obtain quantitative knowledge of ignitions induced by important electric devices in nuclear power plants. These topics have been solved mainly experimentally, but modelling at different level is used to interpret experimental data, and to allow easy generalisation and engineering use of the obtained data. Numerical fire simulation has concentrated in comparison of CFD modelling of room fires, and fire spreading on cables on experimental data. So far the success has been good to fair. A simple analytical and numerical model has been developed for fire effluents spreading beyond the room of origin in mechanically strongly ventilated compartments. For behaviour of equipment in fire several full scale and scaled down calorimetric experiments were carried out on electronic cabinets, as well as on horizontal and vertical cable trays. These were carried out to supply material for CFD numerical simulation code validation. Several analytical models were developed and validated against obtained experimental results to allow quick calculations for PSA estimates as well as inter- and extrapolations to slightly different objects. Response times of different commercial fire detectors were determined for different types of smoke, especially emanating from smoldering and flaming cables to facilitate selection of proper detector

  16. Patient safety: Safety culture and patient safety ethics

    DEFF Research Database (Denmark)

    Madsen, Marlene Dyrløv

    2006-01-01

    and interviews with staff and management in four hospital departments. The appendix contains the Patient Safety Culture Questionnaire tool that I have developed, tested and revised for use in theDanish hospital setting based on the research projects on safety culture described in papers 3, 4 and 5. Paper 6......Patient safety - the prevention of medical error and adverse events - and the initiative of developing safety cultures to assure patients from harm have become one of the central concerns in quality improvement in healthcare both nationally andinternationally. This subject raises numerous...... the problems, and suggest possible solutions for improving patient safety through the promotion of safety culture and ethics. I seek to illuminate theissues of patient safety from several perspectives; the organizational healthcare system, in particular the healthcare workers perspectives and experiences...

  17. Attentional bias toward safety predicts safety behaviors.

    Science.gov (United States)

    Xu, Yaoshan; Li, Yongjuan; Wang, Guangxi; Yuan, Xiao; Ding, Weidong; Shen, Zhongxiang

    2014-10-01

    Safety studies have primarily focused on how explicit processes and measures affect safety behavior and subsequent accidents and injuries. Recently, safety researchers have paid greater attention to the role of implicit processes. Our research focuses on the role of attentional bias toward safety (ABS) in workplace safety. ABS is a basic, early-stage cognitive process involving the automatic and selective allocation of attentional resources toward safety cues, which reflect the implicit motivational state of employees regarding safety goal. In this study, we used two reaction time-based paradigms to measure the ABS of employees in three studies: two modified Stroop tasks (Studies 1 and 2) and a visual dot-probe task (Study 3). Results revealed that employees with better safety behavior showed significant ABS (Study 2), and greater ABS than employees with poorer safety behavior (Studies 1 and 2). Moreover, ABS was positively associated with the perceived safety climate and safety motivation of employees, both of which mediate the effect of ABS on safety behavior (Study 3). These results contributed to a deeper understanding of how early-stage automatic perceptual processing affects safety behavior. The practical implications of these results were also discussed. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. How to evaluate the environmental safety of plant protection products of natural origin - Proposals for decision trees for microbial, semio-chemical, and plant-derived biopesticides: version 1.0

    NARCIS (Netherlands)

    Mensink BJWG; SEC

    2004-01-01

    The environmental safety of crop protection products of natural origin (biopesticides) is to be re-evaluated within a few years' time by the European Union. Also, new biopesticides will enter the EU market, due to the increasing importance of sustainable agriculture. There is, however, almost no gui

  19. 以EHS管理体系构建高校危险化学品安全管理长效机制%The Long-term Mechanism of Safety Mmanagement of Dangerous Chemicals in the Construction of EHS Management System

    Institute of Scientific and Technical Information of China (English)

    罗妮娜; 李峰; 李文辰

    2014-01-01

    Dangerous chemicals are experimental equipment widely used in chemical laboratory, because of its inflammable, explosive, toxic, corrosive and other characteristics, prone to accidents, is one of the im-portant content of the security management. The EHS (environment, health, safety) management system in-cludes the organization of environment, health, safety and their corresponding function, procedure, process and resources. This paper discusses the management of dangerous chemicals exist universities under the new situation of the problem, and the introduction of EHS management system to build long-term mechanism u-niversities dangerous chemicals management.%危险化学品是高校化学实验室广泛使用的实验用品,因其具有易燃、易爆、易中毒、腐蚀性等特点,容易发生安全事故,是高校安全管理工作的重要内容之一。 EHS是指建立环境、健康、安全的组织机构及其职责、程序、过程和资源等构成的整体,是三位一体的管理体系,突出强调事前预防和持续改进,以便最大限度地减少事故、环境污染和人身伤害的发生。本文探讨了新形势下高校危险化学品安全管理存在的问题,并引入EHS管理体系构建高校危险化学品安全管理的长效机制。

  20. A major safety overhaul

    CERN Multimedia

    2003-01-01

    A redefined policy, a revamped safety course, an environmental project... the TIS (Technical Inspection and Safety) Division has begun a major safety overhaul. Its new head, Wolfgang Weingarten, explains to the Bulletin why and how this is happening.

  1. 化学添加剂对食品安全的危害及检测方法研究概况%The General Situation of the Research about the Hazards for Food Safety by Using Chemical Additives and Detection Method

    Institute of Scientific and Technical Information of China (English)

    王连玮

    2011-01-01

    Chemical additives have entered people' s lives by being added in food. Some of the illegal use of chemical additives and high-does abuse resulted in a series of serious food safety incidents. So the research about the hazards of these chemical additives and the detection method is extremely urgent. The overview about various chemical additives which are added in food, toxicological effects and detection method.%化学添加剂通过加入食品中已经全面进入了人们的生活.一些化学添加剂的违规使用和大剂量滥用,造成了一系列严重的食品安全事件.对于这些化学添加剂的危害和检测方法的研究以及对食品安全的监控已经迫在眉睫.对添加于食品中的多种化学添加剂,从毒理作用和检测方法方面进行了概述.

  2. Nuclear criticality safety guide

    Energy Technology Data Exchange (ETDEWEB)

    Pruvost, N.L.; Paxton, H.C. [eds.

    1996-09-01

    This technical reference document cites information related to nuclear criticality safety principles, experience, and practice. The document also provides general guidance for criticality safety personnel and regulators.

  3. New Safety rules

    CERN Multimedia

    Safety Commission

    2008-01-01

    The revision of CERN Safety rules is in progress and the following new Safety rules have been issued on 15-04-2008: Safety Procedure SP-R1 Establishing, Updating and Publishing CERN Safety rules: http://cern.ch/safety-rules/SP-R1.htm; Safety Regulation SR-S Smoking at CERN: http://cern.ch/safety-rules/SR-S.htm; Safety Regulation SR-M Mechanical Equipment: http://cern.ch/safety-rules/SR-M.htm; General Safety Instruction GSI-M1 Standard Lifting Equipment: http://cern.ch/safety-rules/GSI-M1.htm; General Safety Instruction GSI-M2 Standard Pressure Equipment: http://cern.ch/safety-rules/GSI-M2.htm; General Safety Instruction GSI-M3 Special Mechanical Equipment: http://cern.ch/safety-rules/GSI-M3.htm. These documents apply to all persons under the Director General’s authority. All Safety rules are available at the web page: http://www.cern.ch/safety-rules The Safety Commission

  4. Endocrine disrupting chemicals

    DEFF Research Database (Denmark)

    Mandrup, Karen

    BACKGROUND: Endocrine disrupting chemicals (EDCs) may contribute to reproductive changes in boys in the Western world, however, less is known about influence of EDCs in women. The incidence of precocious breast development is increasing in USA and Europe and mammary gland development has been...... suggested as particularly sensitive to endocrine disruption. Mammary gland examination in toxicological studies may be useful for improving knowledge on possible influences of EDCs on human mammary glands and also be useful for detection of endocrine disrupting effects of chemicals as part of safety testing...... and genistein, a mixture of phytoestrogens, and a mixture of environmentally relevant estrogenic EDCs of various origins. Moreover, mixtures of antiandrogenic chemicals were investigated. These include a mixture of pesticides and a mixture of environmentally relevant anti-androgenic EDCs of various origins...

  5. Component- and plant safety. Bauteil- und Anlagensicherheit

    Energy Technology Data Exchange (ETDEWEB)

    Boehnert, R. (Fachhochschule Koeln (Germany). Fachbereich Anlagen- und Verfahrenstechnik)

    1992-01-01

    Since reliable plants depend on reliable components, the work of engineers entrusted with their planning or maintenance would be unthinkable today without a sufficiently founded safety-engineering knowledge. This book gives a profound introduction to component and plant safety and discusses important licensing aspects. It mainly addresses students of mechanical engineering, chemical engineering, supply and environmental engineering and experienced industrial-planning experts who have some elementary background knowledge of mathematics, mechanics, material science and plant construction. (orig.).

  6. Chemical Processing Department monthly report, October 1963

    Energy Technology Data Exchange (ETDEWEB)

    Young, J. F.; Johnson, W. E.; Reinker, P. H.; Warren, J. H.; McCullugh, R. W.; Harmon, M. K.; Gartin, W. J.; LaFollette, T. G.; Shaw, H. P.; Frank, W. S.; Grim, K. G.; Warren, J. H.

    1963-11-21

    This report, for October 1963 from the Chemical Processing Department at HAPO, discusses the following: Production operation; Purex and Redox operation; Finished products operation; maintenance; Financial operations; facilities engineering; research; employee relations; weapons manufacturing operation; and safety and security.

  7. Chemical Processing Department monthly report, December 1963

    Energy Technology Data Exchange (ETDEWEB)

    1964-01-22

    This report, for December 1963 from the Chemical Processing Department at HAPO, discusses the following: Production operation; Purex and Redox operation; Financial operations; facilities engineering; research; and employee relations. Weapons manufacturing operation; and safety and security.

  8. Good housekeeping: Safety and order in the scientific laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Sims, B. H. (Benjamin H.)

    2002-01-01

    Laboratory safety might not seem, at first, to be very profoundly related to scientific knowledge. Of course safety is a relatively trivial issue in many scientific settings, especially in comparison to the kind of safety concerns found, say, at a construction site or a chemical plant. However, as scientific work has come to involve more exotic chemicals, biological organisms, and forms of radiation, and generally become more industrial in character, safety has become more of a concern. This has occurred alongside a general expansion of government regulation of workplace safety during the 20thc entury, and a recent trend toward extending work lace safety efforts to new kinds of work, including administrative and professional tasks. As a result of these trends, scientists find that they are increasingly being held responsible for following safety regulations in their re{approx}earc

  9. 77 FR 41300 - Hazardous Chemical Reporting: Revisions to the Emergency and Hazardous Chemical Inventory Forms...

    Science.gov (United States)

    2012-07-13

    ... required to prepare or have available a material safety data sheet (MSDS) for a hazardous chemical defined... facility owner or operator is required to submit a MSDS or a list that contains the hazardous chemical... or operator of a facility that must prepare or have available a MSDS for each ``hazardous chemical...

  10. Chemical use

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This is a summary of research and activities related to chemical use on Neal Smith National Wildlife Refuge between 1992 and 2009. The chemicals used on the Refuge...

  11. Chemical Peel

    Science.gov (United States)

    ... 20, 2015. Anitha B. Prevention of complications in chemical peeling. Journal of Cutaneous and Aesthetic Surgery. 2010;3:186. Langsdon PR, et al. Latest chemical peel innovations. Facial and Plastic Surgery Clinics of ...

  12. Chemical Reactors.

    Science.gov (United States)

    Kenney, C. N.

    1980-01-01

    Describes a course, including content, reading list, and presentation on chemical reactors at Cambridge University, England. A brief comparison of chemical engineering education between the United States and England is also given. (JN)

  13. Safety: Preventive Medicine.

    Science.gov (United States)

    Kotula, John R.; Digenakis, Anthony

    1985-01-01

    Underscores the need for community colleges to practice safety within the institutions and to instruct students in workplace safety procedures and requirements. Reviews Occupational Safety and Health Act (OSHA) regulations and their impact on industry and education. Looks at the legal responsibilities of colleges for safety. (DMM)

  14. 道化学火灾、爆炸危险指数法在1,3丁二烯聚合安全性评价中的应用%Application of dow chemical fires and explosive index analysis method in safety evaluation of 1,3 butadiene polymerization process

    Institute of Scientific and Technical Information of China (English)

    王丽敏; 翟润培; 孙友平; 吕彩霞

    2012-01-01

    道化学火灾、爆炸危险指数法是在化工领域中广泛应用的一种评价方法,根据该法制定的指数选取规则,可对工艺单元火灾爆炸危险性进行量化和分级.以某化工厂3000t/a三聚体生产项目为背景,从工艺过程、危险物质、安全设施设计等方面,对1,3丁二烯聚合过程火灾、爆炸危险性进行分析;定量评价工艺装置及所含物料潜在危险性,得出主装置区、储罐区固有危险等级,分析不同状态下安全补偿系数对降低危险等级的影响,提出相应安全对策措施.%Dow chemical fires and explosive index analysis method is a widely used evaluation method in the field of chemical industry. According to the index selection rules, the fire explosion risk of the technics cell could be quantitated and classified. In this paper,taking the project of 3000t/a trimer production in a chemical factory as the background, the fire explosion hazard in the polymerization process of 1,3 butadiene was analyzed on the process, dangerous substances, safety facilities design and other aspects. According to the quantitative evaluation of the potentially danger for process units and materials, the intrinsic danger levels of main plant area and tank farm were obtained and some safety countermeasures were put forward by analyzing the effect of security compensation factor on danger level in different condition.

  15. 76 FR 72216 - Occupational Exposure to Hazardous Chemicals in Laboratories Standard; Extension of the Office of...

    Science.gov (United States)

    2011-11-22

    ... hazardous chemicals in accordance with the Standard's definitions for ``laboratory use of hazardous chemicals'' and ``laboratory scale.'' The Standard requires that these laboratories maintain worker... Occupational Safety and Health Administration Occupational Exposure to Hazardous Chemicals in...

  16. 化工企业可燃液体储罐区的通用安全要求%The General Safety Requirements of Chemical Companies Flammable Liquid Storage Tank Area

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    The article mainly introduce the selection,layout and security monitoring equipment of chemical companies flammable liquid storage tank.%  介绍在化工装置可燃液体罐区储罐的选型、布置和安全监控装备的设置。

  17. Safety at CERN

    CERN Multimedia

    2009-01-01

    Safety is an integral part of our working lives, and should be in our minds whatever job we do at CERN. Ultimately, safety is the responsibility of the Director General – your safety is my concern. That’s why I have this week appointed a new Safety Policy Committee (SAPOCO) that reflects the new Organizational structure of CERN. CERN’s Staff Rules and Regulations clearly lay out in chapter 3 the scope of safety at CERN as well as my responsibilities and yours in safety matters. At CERN, safety is considered in the broadest sense, encompassing occupational Health and Safety, environmental protection, and the safety of equipment and installations. It is my responsibility to put appropriate measures in place to ensure that these conditions are met. And it is the responsibility of us all to ensure that we are fully conversant with safety provisions applicable in our areas of work and that we comply with them. The appointment of a n...

  18. 2007 Chemical Biological Information Systems

    Science.gov (United States)

    2007-01-11

    Security and Safety Lange Kleiweg 137 2288 GJ Rijswijk The Netherlands +31 15 2843276 elena.abadjieva@tno.nl Joint Program Executive Office for Chemical and...JSTO): Ian Sykes IEM: Serge Olszanskyj Steven Stage NSWC Dahlgren: Matt Wolski Preon Moore L-3 Titan (JSTO): Ian Sykes IEM: Serge Olszanskyj

  19. Toxicological evaluation of chemical mixtures

    NARCIS (Netherlands)

    Feron, V.J.; Groten, J.P.

    2002-01-01

    This paper addresses major developments in the safety evaluation of chemical mixtures during the past 15 years, reviews today's state of the art of mixture toxicology, and discusses challenges ahead. Well-thought-out tailor-made mechanistic and empirical designs for studying the toxicity of mixtures

  20. International perspectives on food safety and regulations - a need for harmonized regulations: perspectives in China.

    Science.gov (United States)

    Liu, Xiumei

    2014-08-01

    Food safety is a major livelihood issue and a priority concern in China. Since the Food Safety Law of the People's Republic of China was issued in 2009, the food safety control system has been strengthened through, inter alia, the Food Safety Risk Surveillance System, the Food Safety Risk Assessment System and the Food Safety Standards System. In accordance with the Food Safety Law and regulations for implementation, the Ministry of Health released the 'Twelfth Five-year Plan' of Food Safety Standards. The existing 5000 food-related standards will be integrated. Notwithstanding, the supervision system in China needs to be further improved and strengthened. © 2014 Society of Chemical Industry.

  1. China's Work Safety Report

    Institute of Scientific and Technical Information of China (English)

    Liang Jiakun

    2005-01-01

    @@ General Situation of China's Work Safety in 2004 In 2004, the national work safety situation remained stable as a whole and gained momentum to improve. The totality of accidents held the line and began to drop. The safety conditions in industrial,mining, and commercial/trading enterprises improved. Progress was made in ensuring work safety in the relevant industries and fields. The safety situation in most provinces (autonomous regions, municipalities directly under the Central Government) kept stable.

  2. 论如何加强民营小型化工企业的消防安全%On how to strengthen the fire safety of the private small-scale chemical enterprises

    Institute of Scientific and Technical Information of China (English)

    张一

    2009-01-01

    化工企业生产规模不断扩大,生产中所涉及的物质中可燃有机物所占的份额不断增大,而且生产本身又具有生产方法多种多样、装置规模大型化和生产工艺高参数的特点,这些因素决定了化工企业具有较大的火灾危险性.本文针对化工企业火灾的特点、成因,对化工企业火灾防治进行了研究,分析了化工企业中存在的火灾危险及薄弱环节,结合实际情况提出了相应的预防措施.结果表明有效的火灾预防措施能最大限度地减少发生火灾爆炸事故的机率.因此,及时有效地对化工企业中存在的潜在危险做好预防措施是十分必要的.%The chemical industry continued to expand production scale, the share of combustible organic matter of substances involved in production was increasing, but the production itself has characteristics of a variety of production methods, large-scale devices and production process by high parameters, these factors determine the chemical industries have greater risk of fire. This paper aimed at the characteristics and the cause of the fire in chemical industries, to conduct a study of the prevention and control of the fire in chemical companies; analyzed the fire risk and the weak link of the chemical enterprises, combining with the actual situation suggested the corresponding preventive measures. The results shows that the effective fire prevention measures can minimize the fire risk of explosion, therefore, timely and effective preventive measures are essential to the potential risk of in the chemical industries.

  3. TWRS safety program plan

    Energy Technology Data Exchange (ETDEWEB)

    Calderon, L.M., Westinghouse Hanford

    1996-08-01

    Management of Nuclear Safety, Industrial Safety, Industrial Hygiene, and Fire Protection programs, functions, and field support resources for Tank Waste Remediation Systems (TWRS) has, until recently, been centralized in TWRS Safety, under the Emergency, Safety, and Quality organization. Industrial hygiene technician services were also provided to support operational needs related to safety basis compliance. Due to WHC decentralization of safety and reengineering efforts in West Tank Farms, staffing and safety responsibilities have been transferred to the facilities. Under the new structure, safety personnel for TWRS are assigned directly to East Tank Farms, West Tank Farms, and a core Safety Group in TWRS Engineering. The Characterization Project Operations (CPO) safety organization will remain in tact as it currently exists. Personnel assigned to East Tank Farms, West Tank Farms, and CPO will perform facility-specific or project-specific duties and provide field implementation of programs. Those assigned to the core group will focus on activities having a TWRS-wide or programmatic focus. Hanford-wide activities will be the responsibility of the Safety Center of Expertise. In order to ensure an effective and consistent safety program for TWRS under the new organization program functions, goals, organizational structure, roles, responsibilities, and path forward must be clearly established. The purpose of the TWRS Safety Program Plan is to define the overall safety program, responsibilities, relationships, and communication linkages for safety personnel under the new structure. In addition, issues associated with reorganization transition are addressed, including training, project ownership, records management, and dissemination of equipment. For the purpose of this document ``TWRS Safety`` refers to all safety professionals and technicians (Industrial Safety, Industrial Hygiene, Fire Protection, and Nuclear Safety) within the TWRS organization, regardless of their

  4. DECHEMA annual meetings `96. Summaries. Vol. 2. Plenary papers, technical meeting on safety technology, technical meeting on computer applications in the chemical industry, technical meeting on membranes in process technology, technical meeting on dispersions, technical meeting on reaction technology, information day on sonochemistry; DECHEMA-Jahrestagungen `96. Kurzfassungen. Bd. 2. Plenarvortraege - Fachtreffen Sicherheitstechnik - Fachtreffen Computeranwendung in der Chemischen Industrie - Fachtreffen Membranen in der Prozesstechnik - Fachtreffen Dispersionen - Fachtreffen Reaktionstechnik - Informationstag Sonochemie

    Energy Technology Data Exchange (ETDEWEB)

    Kreysa, G. [ed.

    1996-08-01

    This volume comprises the programme of the annual meeting and the summaries of the lectures given. The following subjects were discussed: Safety technology, computer applications in the chemical industry, membranes in process technology, dispersions, reaction technology, sonochemistry. (SR) [Deutsch] Dieser Band enthaelt das Programm der Jahrestagung und die Kurzfassungen der Vortraege. Folgende Gebiete werden behandelt: Sicherheitstechnik, Computeranwendungen in der Chemischen Industrie, Membranen in der Prozesstechnik, Dispersionen, Reaktionstechnik, Sonochemie. (SR)

  5. Occupational safety motivation

    DEFF Research Database (Denmark)

    Pedersen, Louise; Kines, Pete

    2010-01-01

    . At the same time many motivation questionnaire items are seldom founded on theory and/or do not account for the theories’ ontological and epistemological differences, e.g. of how knowledge, attitude and action are related. Present questionnaire items tap into occupational safety motivation in asking whether...... or not respondents ‘are’ motivated and whether they feel that safety is important or worthwhile. Another important aspect is ‘what’ motivates workers to comply to and participate in safety. The aim of this article is to introduce a new theory-based occupational safety motivation scale which is validated......Background: Motivation is one of the most important factors for safety behaviour and for implementing change in general. However, theoretical and psychometric studies of safety performance have traditionally treated safety motivation, safety compliance and safety participation unidimensionally...

  6. Occupational safety motivation

    DEFF Research Database (Denmark)

    Pedersen, Louise; Kines, Pete

    2010-01-01

    . At the same time many motivation questionnaire items are seldom founded on theory and/or do not account for the theories’ ontological and epistemological differences, e.g. of how knowledge, attitude and action are related. Present questionnaire items tap into occupational safety motivation in asking whether...... or not respondents ‘are’ motivated and whether they feel that safety is important or worthwhile. Another important aspect is ‘what’ motivates workers to comply to and participate in safety. The aim of this article is to introduce a new theory-based occupational safety motivation scale which is validated......Background: Motivation is one of the most important factors for safety behaviour and for implementing change in general. However, theoretical and psychometric studies of safety performance have traditionally treated safety motivation, safety compliance and safety participation unidimensionally...

  7. Standardized chemical synthesis of Pseudomonas aeruginosa pyocyanin

    Directory of Open Access Journals (Sweden)

    Rajkumar Cheluvappa

    2014-01-01

    As we have extracted pyocyanin both from P. aeruginosa cultures, and via chemical synthesis; we know the procedural and product-quality differences. We endorse the relative ease, safety, and convenience of using the chemical synthesis described here. Crucially, our “naturally endotoxin-free” pyocyanin can be extracted easily without using infectious bacteria.

  8. Better Tomorrow of China Rubber Chemicals Industry

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    I. Development of China Rubber Chemicals Industry During the "11th Five-Year Plan" period, China rubber Chemicals industry fully implemented the development guideline of "Adhering to science and technology development, developing green chemistry with environmental protection, safety and energy conservation as the core, and building enterprise and world brands". With the great support of the state,

  9. Agricultural pest control programmes, food security and safety | Eze ...

    African Journals Online (AJOL)

    Agricultural pest control programmes, food security and safety. ... of some of the pests to the chemical pesticides, coupled with potential health hazards on the ... or post harvest treatments and basic information regarding the individual farmer or ...

  10. Safety-barrier diagrams

    DEFF Research Database (Denmark)

    Duijm, Nijs Jan

    2007-01-01

    are discussed. A simple method for quantification of safety-barrier diagrams is proposed, including situations where safety barriers depend on shared common elements. It is concluded that safety-barrier diagrams provide a useful framework for an electronic data structure that integrates information from risk......Safety-barrier diagrams and the related so-called "bow-tie" diagrams have become popular methods in risk analysis. This paper describes the syntax and principles for constructing consistent and valid safety-barrier diagrams. The relation with other methods such as fault trees and Bayesian networks...... analysis with operational safety management....

  11. Safety-in-numbers

    DEFF Research Database (Denmark)

    Elvik, Rune; Bjørnskau, Torkel

    2017-01-01

    Highlights •26 studies of the safety-in-numbers effect are reviewed. •The existence of a safety-in-numbers effect is confirmed. •Results are consistent. •Causes of the safety-in-numbers effect are incompletely known.......Highlights •26 studies of the safety-in-numbers effect are reviewed. •The existence of a safety-in-numbers effect is confirmed. •Results are consistent. •Causes of the safety-in-numbers effect are incompletely known....

  12. Beyond safety accountability

    CERN Document Server

    Geller, E Scott

    2001-01-01

    Written in an easy-to-read conversational tone, Beyond Safety Accountability explains how to develop an organizational culture that encourages people to be accountable for their work practices and to embrace a higher sense of personal responsibility. The author begins by thoroughly explaining the difference between safety accountability and safety responsibility. He then examines the need of organizations to improve safety performance, discusses why such performance improvement can be achieved through a continuous safety process, as distinguished from a safety program, and provides the practic

  13. Safety evaluation of natural flavour complexes

    NARCIS (Netherlands)

    Smith, R.L.; Adams, T.B.; Cohen, S.M.; Doull, J.; Feron, V.J.; Goodman, J.I.; Hall, R.L.; Marnett, L.J.; Portoghese, P.S.; Waddell, W.J.; Wagner, B.M.

    2004-01-01

    Natural flavour complexes (NFCs) are chemical mixtures obtained by applying physical separation methods to botanical sources. Many NFCs are derived from foods. In the present paper, a 12-step procedure for the safety evaluation of NFCs, 'the naturals paradigm', is discussed. This procedure, which is

  14. Safety evaluation of natural flavour complexes

    NARCIS (Netherlands)

    Smith, R.L.; Adams, T.B.; Cohen, S.M.; Doull, J.; Feron, V.J.; Goodman, J.I.; Hall, R.L.; Marnett, L.J.; Portoghese, P.S.; Waddell, W.J.; Wagner, B.M.

    2004-01-01

    Natural flavour complexes (NFCs) are chemical mixtures obtained by applying physical separation methods to botanical sources. Many NFCs are derived from foods. In the present paper, a 12-step procedure for the safety evaluation of NFCs, 'the naturals paradigm', is discussed. This procedure, which is

  15. Safety KPIs - Monitoring of safety performance

    Directory of Open Access Journals (Sweden)

    Andrej Lališ

    2014-09-01

    Full Text Available This paper aims to provide brief overview of aviation safety development focusing on modern trends represented by implementation of Safety Key Performance Indicators. Even though aviation is perceived as safe means of transport, it is still struggling with its complexity given by long-term growth and robustness which it has reached today. Thus nowadays safety issues are much more complex and harder to handle than ever before. We are more and more concerned about organizational factors and control mechanisms which have potential to further increase level of aviation safety. Within this paper we will not only introduce the concept of Key Performance Indicators in area of aviation safety as an efficient control mechanism, but also analyse available legislation and documentation. Finally we will propose complex set of indicators which could be applied to Czech Air Navigation Service Provider.

  16. (Q)SAR modeling and safety assessment in regulatory review.

    Science.gov (United States)

    Kruhlak, N L; Benz, R D; Zhou, H; Colatsky, T J

    2012-03-01

    The ability to predict clinical safety based on chemical structures is becoming an increasingly important part of regulatory decision making. (Quantitative) structure-activity relationship ((Q)SAR) models are currently used to evaluate late-arising safety concerns and possible nonclinical effects of a drug and its related compounds when adequate safety data are absent or equivocal. Regulatory use will likely increase with the standardization of analytical approaches, more complete and reliable data collection methods, and a better understanding of toxicity mechanisms.

  17. 30 CFR 75.1101-13 - Dry powder chemical systems; general.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Dry powder chemical systems; general. 75.1101-13 Section 75.1101-13 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Fire Protection § 75.1101-13 Dry powder chemical systems;...

  18. Chemical sensors

    Science.gov (United States)

    Lowell, J.R. Jr.; Edlund, D.J.; Friesen, D.T.; Rayfield, G.W.

    1991-07-02

    Sensors responsive to small changes in the concentration of chemical species are disclosed. The sensors comprise a mechanochemically responsive polymeric film capable of expansion or contraction in response to a change in its chemical environment. They are operatively coupled to a transducer capable of directly converting the expansion or contraction to a measurable electrical response. 9 figures.

  19. Safety climate and safety behavior in the passenger ferry context.

    Science.gov (United States)

    Lu, Chin-Shan; Yang, Chung-Shan

    2011-01-01

    This research empirically evaluates safety climate and safety behavior in the passenger ferry context. Using survey data collected from 155 respondents working for passenger ferry companies in Taiwan, hierarchical regression analysis was used to examine the effects of safety climate on self-reported safety behaviors. Confirmatory factor analysis identified five main dimensions of safety climate as measured on a passenger ferry safety climate scale: safety policy, safety motivation, emergency preparedness, safety training, and safety communication. Further, safety training and emergency preparedness were found to positively affect self-reported safety behaviors with respect to safety compliance and safety participation. The study also revealed positive associations among respondents' age, ferry capacity, and safety compliance. Implications of the study findings for increasing safety in ferry operations and their contribution to the development of safety management are discussed. Copyright © 2010 Elsevier Ltd. All rights reserved.

  20. Occupational safety of different industrial sectors in Khartoum State, Sudan. Part 1: Safety performance evaluation.

    Science.gov (United States)

    Zaki, Gehan R; El-Marakby, Fadia A; H Deign El-Nor, Yasser; Nofal, Faten H; Zakaria, Adel M

    2012-12-01

    Safety performance evaluation enables decision makers improve safety acts. In Sudan, accident records, statistics, and safety performance were not evaluated before maintenance of accident records became mandatory in 2005. This study aimed at evaluating and comparing safety performance by accident records among different cities and industrial sectors in Khartoum state, Sudan, during the period from 2005 to 2007. This was a retrospective study, the sample in which represented all industrial enterprises in Khartoum state employing 50 workers or more. All industrial accident records of the Ministry of Manpower and Health and those of different enterprises during the period from 2005 to 2007 were reviewed. The safety performance indicators used within this study were the frequency-severity index (FSI) and fatal and disabling accident frequency rates (DAFR). In Khartoum city, the FSI [0.10 (0.17)] was lower than that in Bahari [0.11 (0.21)] and Omdurman [0.84 (0.34)]. It was the maximum in the chemical sector [0.33 (0.64)] and minimum in the metallurgic sector [0.09 (0.19)]. The highest DAFR was observed in Omdurman [5.6 (3.5)] and in the chemical sector [2.5 (4.0)]. The fatal accident frequency rate in the mechanical and electrical engineering industry was the highest [0.0 (0.69)]. Male workers who were older, divorced, and had lower levels of education had the lowest safety performance indicators. The safety performance of the industrial enterprises in Khartoum city was the best. The safety performance in the chemical sector was the worst with regard to FSI and DAFR. The age, sex, and educational level of injured workers greatly affect safety performance.

  1. Water safety and drowning

    Science.gov (United States)

    ... among people of all ages. Learning and practicing water safety is important to prevent drowning accidents. ... Water safety tips for all ages include: Learn CPR Never swim alone Never dive into water unless ...

  2. Gun Safety (For Parents)

    Science.gov (United States)

    ... Teaching Kids to Be Smart About Social Media Gun Safety KidsHealth > For Parents > Gun Safety Print A ... unloaded, and the ammunition should be stored separately. Guns and Pretend Play Allowing kids to play with ...

  3. Water Safety Quiz

    Science.gov (United States)

    ... Prepare for Emergencies Types of Emergencies Take the Water Safety Quiz Trivia quiz loading... Please enable javascript. Stay Safe Around Water Download water safety tips in English or Spanish ...

  4. Medicine safety and children

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000619.htm Medicine safety and children To use the sharing features ... especially careful if you have toddlers around. Keep Medicines out of Reach and Sight Safety tips: DO ...

  5. Refrigeration and Food Safety

    Science.gov (United States)

    ... Standard Forms FSIS United States Department of Agriculture Food Safety and Inspection Service About FSIS District Offices Careers ... Viewer (JSR 286) Actions ${title} Loading... Refrigeration and Food Safety History of Refrigeration Importance of Refrigeration Types of ...

  6. Fires and Food Safety

    Science.gov (United States)

    ... Standard Forms FSIS United States Department of Agriculture Food Safety and Inspection Service About FSIS District Offices Careers ... Viewer (JSR 286) Actions ${title} Loading... Fires and Food Safety Fire! Few words can strike such terror. Residential ...

  7. Electrical safety guidelines

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-01

    The Electrical Safety Guidelines prescribes the DOE safety standards for DOE field offices or facilities involved in the use of electrical energy. It has been prepared to provide a uniform set of electrical safety standards and guidance for DOE installations in order to affect a reduction or elimination of risks associated with the use of electrical energy. The objectives of these guidelines are to enhance electrical safety awareness and mitigate electrical hazards to employees, the public, and the environment.

  8. DOE handbook electrical safety

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-01

    Electrical Safety Handbook presents the Department of Energy (DOE) safety standards for DOE field offices or facilities involved in the use of electrical energy. It has been prepared to provide a uniform set of electrical safety guidance and information for DOE installations to effect a reduction or elimination of risks associated with the use of electrical energy. The objectives of this handbook are to enhance electrical safety awareness and mitigate electrical hazards to employees, the public, and the environment.

  9. Safety of probiotics

    OpenAIRE

    Gueimonde, Miguel; Ouwehand, Arthur C.; Salminen, Seppo

    2004-01-01

    The use of probiotics in foods has increased significantly and there are more and more products available with high numbers of viable probiotics. This article reviews the safety information on probiotic microorganisms. A literature search and assessment of safety data on current probiotics were undertaken. No significant safety concerns for current probiotics were observed. The available data attest to the safety of Lactobacillus and Bifidobacterium probiotics. In conclusion, current probioti...

  10. Generic safety documentation model

    Energy Technology Data Exchange (ETDEWEB)

    Mahn, J.A.

    1994-04-01

    This document is intended to be a resource for preparers of safety documentation for Sandia National Laboratories, New Mexico facilities. It provides standardized discussions of some topics that are generic to most, if not all, Sandia/NM facilities safety documents. The material provides a ``core`` upon which to develop facility-specific safety documentation. The use of the information in this document will reduce the cost of safety document preparation and improve consistency of information.

  11. Health care worker safety in surgery.

    Science.gov (United States)

    King, Cecil A

    2011-11-01

    Nursing is ranked as one of the occupations with the most incidences of workplace-related injury and illness. The six types of injury risk specific to the perioperative environment are biological, ergonomic, chemical, physical, psychosocial, and cultural in nature. Strategies to improve safety include the use of engineering controls to change the work environment, the equipment used, and how the work is done; administrative controls, such as implementing policies and procedures to develop a culture of safety; and behavioral controls that individuals can exercise to reduce the risk of injury. In addition, every perioperative RN is responsible for following safety policies and has the responsibility to identify safety hazards, take appropriate actions, and report the hazards through appropriate channels.

  12. General safety considerations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-09-01

    This document presents the full filling of the Brazilian obligations under the Convention on Nuclear Safety. The Chapter 4 of the document contains some details about the priority to safety, financial and human resources, human factors, quality assurance, safety assessment and verification, radiation protection and emergency preparedness.

  13. General safety considerations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    This document presents the full filling of the Brazilian obligations under the Convention on Nuclear Safety. The Chapter 4 of the document contains some details about the priority to safety, financial and human resources, human factors, quality assurance, safety assessment and verification, radiation protection and emergency preparedness.

  14. Revitalizing Nuclear Safety Research.

    Science.gov (United States)

    National Academy of Sciences - National Research Council, Washington, DC.

    This report covers the general issues involved in nuclear safety research and points out the areas needing detailed consideration. Topics included are: (1) "Principles of Nuclear Safety Research" (examining who should fund, who should conduct, and who should set the agenda for nuclear safety research); (2) "Elements of a Future…

  15. Leadership and safety culture. Leadership for safety

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Erwin; Nithack, Eckhard [PreussenElektra GmbH, Hannover (Germany)

    2016-08-15

    The meaning of leadership for safety in the nuclear industry is pointed out. This topic has became an increasing rank since the German ''Energiewende''. Despite the phase-out of the German NPP's nuclear safety and the belonging safety culture needs to be well maintained. A challenge for the whole organisation. Following the challenge to operate nuclear power plants towards Operational Excellence a highly skilled and motivated organisation is needed. Therefore Leadership is a valuable success factor.

  16. Hazardous Chemicals

    Centers for Disease Control (CDC) Podcasts

    2007-04-10

    Chemicals are a part of our daily lives, providing many products and modern conveniences. With more than three decades of experience, The Centers for Disease Control and Prevention (CDC) has been in the forefront of efforts to protect and assess people's exposure to environmental and hazardous chemicals. This report provides information about hazardous chemicals and useful tips on how to protect you and your family from harmful exposure.  Created: 4/10/2007 by CDC National Center for Environmental Health.   Date Released: 4/13/2007.

  17. Methodological innovations expand the safety pharmacology horizon.

    Science.gov (United States)

    Pugsley, M K; Curtis, M J

    2012-09-01

    Almost uniquely in pharmacology, drug safety assessment is driven by the need for elaboration and validation of methods for detecting drug actions. This is the 9th consecutive year that the Journal of Pharmacological and Toxicological Methods (JPTM) has published themed issues arising from the annual meeting of the Safety Pharmacology Society (SPS). The SPS is now past its 10th year as a distinct (from pharmacology to toxicology) discipline that integrates safety pharmacologists from industry with those in academia and the various global regulatory authorities. The themes of the 2011 meeting were (i) the bridging of safety assessment of a new chemical entity (NCE) between all the parties involved, (ii) applied technologies and (iii) translation. This issue of JPTM reflects these themes. The content is informed by the regulatory guidance documents (S7A and S7B) that apply prior to first in human (FIH) studies, which emphasize the importance of seeking model validation. The manuscripts encompass a broad spectrum of safety pharmacology topics including application of state-of-the-art techniques for study conduct and data processing and evaluation. This includes some exciting novel integrated core battery study designs, refinements in hemodynamic assessment, arrhythmia analysis algorithms, and additionally an overview of safety immunopharmacology, and a brief survey discussing similarities and differences in business models that pharmaceutical companies employ in safety pharmacology, together with SPS recommendations on 'best practice' for the conduct of a non-clinical cardiovascular assessment of a NCE.

  18. Safety of cosmetic dermatologic procedures during pregnancy.

    Science.gov (United States)

    Lee, Kachiu C; Korgavkar, Kaveri; Dufresne, Raymond G; Higgins, H William

    2013-11-01

    Safety of cosmetic procedures in pregnant women has not been extensively studied. Maternal and fetal health risks are important to consider in any procedure performed. With the increasing popularity of cosmetic procedures, dermatologic surgeons will be faced with scenarios necessitating knowledge regarding the safety of such procedures during pregnancy. Furthermore, dermatologic surgeons may inadvertently perform cosmetic procedures during the first trimester, before the patient is aware of the pregnancy. To investigate the safety of cosmetic procedures during pregnancy and the postpartum period. A literature search of PubMed and Google Scholar was conducted of all English-language articles published from 1960 through 2012. Definitive recommendations on the safety of procedures such as chemical peels, injectables, fillers, and most laser therapies during pregnancy cannot be made. The safety of onabotulinum toxin usage is well documented in the neurology literature, although isolated events of miscarriage have been reported with high doses of toxin in women with a previous history of miscarriage. Carbon dioxide laser therapy for genital condylomas has considerable evidence supporting its safety during pregnancy. There is a lack of controlled trials addressing the safety of cosmetic procedures during pregnancy and postpartum periods. It is advisable to delay elective cosmetic procedures until after the baby is born. © 2013 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.

  19. Wearable Optical Chemical Sensors

    Science.gov (United States)

    Lobnik, Aleksandra

    Wearable sensors can be used to provide valuable information about the wearer's health and/or monitor the wearer's surroundings, identify safety concerns and detect threats, during the wearer's daily routine within his or her natural environment. The "sensor on a textile", an integrated sensor capable of analyzing data, would enable early many forms of detection. Moreover, a sensor connected with a smart delivery system could simultaneously provide comfort and monitoring (for safety and/or health), non-invasive measurements, no laboratory sampling, continuous monitoring during the daily activity of the person, and possible multi-parameter analysis and monitoring. However, in order for the technology to be accessible, it must remain innocuous and impose a minimal intrusion on the daily activities of the wearer. Therefore, such wearable technologies should be soft, flexible, and washable in order to meet the expectations of normal clothing. Optical chemical sensors (OCSs) could be used as wearable technology since they can be embedded into textile structures by using conventional dyeing, printing processes and coatings, while fiber-optic chemical sensors (FOCSs) as well as nanofiber sensors (NFSs) can be incorporated by weaving, knitting or laminating. The interest in small, robust and sensitive sensors that can be embedded into textile structures is increasing and the research activity on this topic is an important issue.

  20. Fusion safety program annual report fiscal year 1997

    Energy Technology Data Exchange (ETDEWEB)

    Longhurst, G.R.; Anderl, R.A.; Cadwallader, L.C. [and others

    1998-01-01

    This report summarizes the major activities of the Fusion Safety Program in FY 1997. The Idaho National Engineering and Environmental Laboratory (INEEL) is the designated lead laboratory, and Lockheed Martin Idaho Technologies Company is the prime contractor for this program. The Fusion Safety Program was initiated in FY 1979 to perform research and develop data needed to ensure safety in fusion facilities. Activities include experiments, analysis, code development and application, and other forms of research. These activities are conducted at the INEEL, different DOE laboratories, and other institutions. The technical areas covered in this report include chemical reactions and activation product release, tritium safety, risk assessment failure rate database development, and safety code development and application to fusion safety issues. Most of this work has been done in support of the International Thermonuclear Experimental Reactor (ITER) project. Work done for ITER this year has focused on developing the needed information for the Non-site Specific Safety Report (NSSR-2).

  1. Safety survives privatisation

    Energy Technology Data Exchange (ETDEWEB)

    Cunnigham, P. [Health and Safety Executive, Sheffield (United Kingdom)

    1995-01-01

    The privatisation of British Coal will have no effect on safety standards in the industry since the new companies will still be governed by the same safety regulations. The Health and Safety Executive does not just inspect, it relies also on information exchange, in the surface mining sector particularly through the quarries National Interest Group, since good health and safety working practices save money. Future trends include compliance with the European Community directives on health and safety, although much of this is covered already. 3 figs.

  2. Safety Study in Aviation

    Directory of Open Access Journals (Sweden)

    Marek Štumper

    2016-07-01

    Full Text Available The objective of this article is to provide a brief look at safety studies, which are a necessary part of every change of system or a new system in aviation. The main focus is put on the area of air traffic management, because it affects most of the aviation stakeholders. The article begins with a description of safety and safety assessment of changes in systems. Then it discusses analysis of processes, hazard identification and risk assessment. Main part focuses on Safety studies and briefly describes the elements of the study. At the end, possible ways of safety study evaluation are mentioned.

  3. Nuclear safety in perspective

    DEFF Research Database (Denmark)

    Andersson, K.; Sjöberg, B.M.D.; Lauridsen, Kurt

    2003-01-01

    The aim of the NKS/SOS-1 project has been to enhance common understanding about requirements for nuclear safety by finding improved means of communicat-ing on the subject in society. The project, which has been built around a number of seminars, wassupported by limited research in three sub......-projects: Risk assessment Safety analysis Strategies for safety management The report describes an industry in change due to societal factors. The concepts of risk and safety, safety management and systems forregulatory oversight are de-scribed in the nuclear area and also, to widen the perspective, for other...

  4. CHEMICAL PROPERTIES.

    African Journals Online (AJOL)

    However, the amount of soil organic matter and total nitrogen content was. T DIFFERENT HOURS ... burning such as improvement in soil physical ... chemical properties. The aim is to find .... Humid Tropics with particular reference to. Nigeria.

  5. Safety & Regulatory Strategy : Food Safety and Innovation

    NARCIS (Netherlands)

    Kalk, C.

    2013-01-01

    Food and feed safety is strictly regulated within the EU. Our team of toxicologists, risk assessors and consultants offers strategic advice and valuable expertise in regulatory affairs and health risk assessment.

  6. Safety in Cryogenics – Safety device sizing

    CERN Document Server

    CERN. Geneva

    2016-01-01

    The calculation is separated in three operations: o The estimation of the loads arriving on the component to protect, o The calculation of the mass flow to evacuate, o And the sizing of the safety device.

  7. Pediatric safety pin ingestion.

    Science.gov (United States)

    Sarihan, H; Kaklikkaya, I; Ozcan, F

    1998-08-01

    Fifteen consecutive children with ingested safety pins were evaluated retrospectively. Eight patients were males and seven were girls. The mean age of the patients was 5.4 years ranging from 7 months to 16 years. Two of 15 patients were mentally retarded Seven safety pins ingestion were noted by parents, three older children applied with safety pin swallowing. Three infants referred with hypersalivation and swallowing difficulty. One of two mentally retarded patients had recurrent aspiration pneumonia, the other had neck abscess. These patients' lesions were detected incidentally by thoracic X-ray. Nine safety pins were at the level of the cricopharyngeus, one at the level of the aortic arch and five at the esophagogastric junction. A right esophagoscopy was used for extraction of safety pins under general anesthesia and endotracheal intubation were used. Before esophagoscopy control plain X-ray was obtained for location of safety pin. Nine safety pins were extracted by esophagoscopy. Three safety pins spontaneously and three during anesthesia induction passed through the esophagus falling down the stomach. Five of these six safety pins were spontaneously extracted without complication. However one open safety pin lodged at the duodenum and laparotomy was required. In this article, etiology and management of safety pin ingestion in children are discussed.

  8. Benchmarking Global Food Safety Performances: The Era of Risk Intelligence.

    Science.gov (United States)

    Valleé, Jean-Charles Le; Charlebois, Sylvain

    2015-10-01

    Food safety data segmentation and limitations hamper the world's ability to select, build up, monitor, and evaluate food safety performance. Currently, there is no metric that captures the entire food safety system, and performance data are not collected strategically on a global scale. Therefore, food safety benchmarking is essential not only to help monitor ongoing performance but also to inform continued food safety system design, adoption, and implementation toward more efficient and effective food safety preparedness, responsiveness, and accountability. This comparative study identifies and evaluates common elements among global food safety systems. It provides an overall world ranking of food safety performance for 17 Organisation for Economic Co-Operation and Development (OECD) countries, illustrated by 10 indicators organized across three food safety risk governance domains: risk assessment (chemical risks, microbial risks, and national reporting on food consumption), risk management (national food safety capacities, food recalls, food traceability, and radionuclides standards), and risk communication (allergenic risks, labeling, and public trust). Results show all countries have very high food safety standards, but Canada and Ireland, followed by France, earned excellent grades relative to their peers. However, any subsequent global ranking study should consider the development of survey instruments to gather adequate and comparable national evidence on food safety.

  9. Patient Safety Culture

    DEFF Research Database (Denmark)

    Kristensen, Solvejg

    of health care professional’s behaviour, habits, norms, values, and basic assumptions related to patient care; it is the way things are done. The patient safety culture guides the motivation, commitment to and know-how of the safety management, and how all members of a work place interact. This thesis......Patient safety is highly prioritised in the Danish health care system, never the less, patients are still exposed to risk and harmed every day. Implementation of a patient safety culture has been suggested an effective mean to protect patients against adverse events. Working strategically...... with assessment and development of the patient safety culture is in early days in Denmark. It depends upon valid, reliable and effective methods. The patient safety culture represents a wide range of social phenomena permeating the way of life in a health care. In essence, the safety culture is an aggregation...

  10. The safety relief valve handbook design and use of process safety valves to ASME and International codes and standards

    CERN Document Server

    Hellemans, Marc

    2009-01-01

    The Safety Valve Handbook is a professional reference for design, process, instrumentation, plant and maintenance engineers who work with fluid flow and transportation systems in the process industries, which covers the chemical, oil and gas, water, paper and pulp, food and bio products and energy sectors. It meets the need of engineers who have responsibilities for specifying, installing, inspecting or maintaining safety valves and flow control systems. It will also be an important reference for process safety and loss prevention engineers, environmental engineers, and plant and process designers who need to understand the operation of safety valves in a wider equipment or plant design context. . No other publication is dedicated to safety valves or to the extensive codes and standards that govern their installation and use. A single source means users save time in searching for specific information about safety valves. . The Safety Valve Handbook contains all of the vital technical and standards informat...

  11. Nuclear Safety for Space Systems

    Science.gov (United States)

    Offiong, Etim

    2010-09-01

    It is trite, albeit a truism, to say that nuclear power can provide propulsion thrust needed to launch space vehicles and also, to provide electricity for powering on-board systems, especially for missions to the Moon, Mars and other deep space missions. Nuclear Power Sources(NPSs) are known to provide more capabilities than solar power, fuel cells and conventional chemical means. The worry has always been that of safety. The earliest superpowers(US and former Soviet Union) have designed and launched several nuclear-powered systems, with some failures. Nuclear failures and accidents, however little the number, could be far-reaching geographically, and are catastrophic to humans and the environment. Building on the numerous research works on nuclear power on Earth and in space, this paper seeks to bring to bear, issues relating to safety of space systems - spacecrafts, astronauts, Earth environment and extra terrestrial habitats - in the use and application of nuclear power sources. It also introduces a new formal training course in Space Systems Safety.

  12. [Dioxins and food safety].

    Science.gov (United States)

    Struciński, Paweł; Piskorska-Pliszczyńska, Jadwiga; Góralczyk, Katarzyna; Warenik-Bany, Małgorzata; Maszewski, Sebastian; Czaja, Katarzyna; Ludwicki, Jan K

    2011-01-01

    Among numerous potential chemical food contaminants, polychlorinated dibenzo-p-dioxins, dibenzofurans and dioxin-like polychlorinated biphenyls, collectively referred as dioxins, are commonly considered as bearing substantial risk for human health due to their toxicological properties, persistency and ability to bioaccumulate in food chains. The results of epidemiological studies suggest that environmental exposure to these compounds may affect multiple physiological processes in humans, mainly by the mechanism of endocrine disruption. Adverse health effects linked to the long-term exposure to dioxins include the increase of cancer risk, reproductive and developmental impairment as well as effects on immune functions. Exposure through food (mainly of animal origin) is the major source of dioxin exposure for humans, estimated to account for about 95% of the total intake for non-occupationally exposed persons. Recent studies showed that a consistent part of the European population has an intake exceeding internationally agreed "safe" doses as the Tolerable Daily or Weekly Intake (TDI, TWI). It is worthy to note that percentage of persons with estimated dioxin intake above tolerable limits is much higher among children than in adults. Since the "Belgian dioxin crisis" that occurred in 1999, the estimation of human exposure to these compounds and related consumer risk assessment has been recognized in the European Union as one of the priority activities in the field of food safety. Among activities undertaken by the European Commission during implementation of the Community Strategy for dioxins, furans and polychlorinated biphenyls the maximum and action levels have been established with random monitoring by Member States. The legislation on the requirements for sampling and methods of analysis used in the official control laboratories has been set up as well. Member States are obliged to measure background levels of dioxins and dioxin-like PCBs in defined food

  13. 空气波压力治疗仪用于产妇剖宫产术后预防双下肢深静脉血栓形成的护理干预%Nursing Intervention of IPC on Deep Vein Thrombosis Prevention After Cesarean Delivery

    Institute of Scientific and Technical Information of China (English)

    黄玉宇

    2016-01-01

    Objective To explore the clinical nursing intervention of IPC on deep vein thrombosis prevention after cesarean delivery. Methods 126 cases of puerpera after cesarean section surgery in our hospital were selected and divided into two groups based on different nursing methods, with 63 cases in each group. The observation group was given IPC nursing, while the control group was given routine massage nursing. The nursing effects of two groups were observed and compared. Results After nursing, the total effective rate of observation group was 100.0%, significantly higher than 88.9% of control group (P <0.05). Conclusions The application of IPC after cesarean delivery of hypercoagulable maternal can effectively prevent the formation of deep vein thrombosis, and improve the clinical effect.%目的 探讨产妇剖宫产术后采用空气波压力治疗仪预防双下肢深静脉血栓形成的临床护理干预. 方法 选取我院收治的行剖宫产手术的产妇126例, 按照护理方式的不同分为观察组和对照组, 每组63例; 观察组产妇术后给予空气波压力治疗仪护理, 对照组产妇术后给予常规按摩护理, 观察比较两组的护理效果. 结果 护理后, 观察组的总有效率为100.0%, 显著高于对照组的88.9%, 差异具有统计学意义 (P<0.05). 结论 产妇剖宫产术后早期应用空气波压力治疗仪并采取相应的护理措施, 可有效地预防产妇术后下肢静脉血栓的形成, 提高临床治疗效果, 疗效显著, 值得临床推广.

  14. 从薄层层析到天然产物工业制备层析的理论与实践%THEORY AND PRACTICE FROM TLC TO INDUSTRIAL PREPARATIVE CHROMATOGRAPHY(IPC)IN THE SEPARATION OF NATURAL PRODUCT

    Institute of Scientific and Technical Information of China (English)

    卢大炎; 康强胜

    2004-01-01

    On the basis of the commonness theory of separation, optimum isolation conditions for components diffi-cult to be separated are established by using thin layer chromatography (TLC), and directly scale up to industrialpreparative chromatography (IPC) of plant-derived natural products. Solvent composition, solvent strength,solventdosage and solvent re-utilization in the practical application are evaluated. The best solvent selectivity for IPC can beobtained by comparing the ratio of Rf value of different solvent systems on TLC plate with compounds being isolated.The dominant polar solvent in eluent govern the peak sequence,and a little of more polar solvent or pH change canmodify tailing peak. And according to the relationship between Rf and capacity factor (K) and eluting volumes, thebest range of solvent strength for IPC judged with Rf value is confirmed from 0.1 to 0.3.%基于分离理论的共性,通过薄层层析优化难分离物质对的最佳分离条件并直接放大到植物天然产物的工业制备分离.本文对实际应用中的溶剂组成、溶剂强度、溶剂用量及溶剂再利用等问题作了详细论述.最佳溶剂选择性可通过不同溶剂系统在薄层板上所给难分离物质对的最大Rf比值确定;在正相硅胶层析中,主要极性溶剂决定了物质的洗脱顺序;洗脱剂中极少量强极性溶剂(0.5%)或pH值的改变可显著改善拖尾现象;根据Rf值和容量因子(K)及洗脱体积三者之间的关系,Rf在0.1~0.3为用于柱层析的洗脱溶剂强度的最佳范围.

  15. Safety and the Human Factor.

    Science.gov (United States)

    Smith, Ann

    1982-01-01

    Discusses four elements of safety programs: (1) safety training; (2) safety inspections; (3) accident investigations; and (4) protective safety equipment. Also discusses safety considerations in water/wastewater treatment facilities focusing on falls, drowning hazards, trickling filters, confined space entry, collection/distribution system safety,…

  16. Analysis, synthesis and design of chemical processes

    Energy Technology Data Exchange (ETDEWEB)

    Turton, R. [West Virginia Univ., Morgantown, WV (United States); Bailie, R.C.; Whiting, W.B.

    1998-12-31

    The book illustrates key concepts through a running example from the real world: the manufacture of benzene; covers design, economic considerations, troubleshooting and health/environmental safety; and includes exclusive software for estimating chemical manufacturing equipment capital costs. This book will help chemical engineers optimize the efficiency of production processes, by providing both a philosophical framework and detailed information about chemical process design. Design is the focal point of the chemical engineering practice. This book helps engineers and senior-level students hone their design skills through process design rather than simply plant design. It introduces all the basics of process simulation. Learn how to size equipment, optimize flowsheets, evaluate the economics of projects, and plan the operation of processes. Learn how to use Process Flow Diagrams; choose the operating conditions for a process; and evaluate the performance of existing processes and equipment. Finally, understand how chemical process design impacts health, safety, the environment and the community.

  17. Principles of safety pharmacology.

    Science.gov (United States)

    Pugsley, M K; Authier, S; Curtis, M J

    2008-08-01

    Safety Pharmacology is a rapidly developing discipline that uses the basic principles of pharmacology in a regulatory-driven process to generate data to inform risk/benefit assessment. The aim of Safety Pharmacology is to characterize the pharmacodynamic/pharmacokinetic (PK/PD) relationship of a drug's adverse effects using continuously evolving methodology. Unlike toxicology, Safety Pharmacology includes within its remit a regulatory requirement to predict the risk of rare lethal events. This gives Safety Pharmacology its unique character. The key issues for Safety Pharmacology are detection of an adverse effect liability, projection of the data into safety margin calculation and finally clinical safety monitoring. This article sets out to explain the drivers for Safety Pharmacology so that the wider pharmacology community is better placed to understand the discipline. It concludes with a summary of principles that may help inform future resolution of unmet needs (especially establishing model validation for accurate risk assessment). Subsequent articles in this issue of the journal address specific aspects of Safety Pharmacology to explore the issues of model choice, the burden of proof and to highlight areas of intensive activity (such as testing for drug-induced rare event liability, and the challenge of testing the safety of so-called biologics (antibodies, gene therapy and so on.).

  18. Major accident prevention through applying safety knowledge management approach.

    Science.gov (United States)

    Kalatpour, Omid

    2016-01-01

    Many scattered resources of knowledge are available to use for chemical accident prevention purposes. The common approach to management process safety, including using databases and referring to the available knowledge has some drawbacks. The main goal of this article was to devise a new emerged knowledge base (KB) for the chemical accident prevention domain. The scattered sources of safety knowledge were identified and scanned. Then, the collected knowledge was formalized through a computerized program. The Protégé software was used to formalize and represent the stored safety knowledge. The domain knowledge retrieved as well as data and information. This optimized approach improved safety and health knowledge management (KM) process and resolved some typical problems in the KM process. Upgrading the traditional resources of safety databases into the KBs can improve the interaction between the users and knowledge repository.

  19. FOOD SAFETY REGULATIONS BASED ON REAL SCIENCE

    Directory of Open Access Journals (Sweden)

    Huub LELIEVELD

    2015-10-01

    Full Text Available Differences in regulations result in needless destruction of safe food and hamper food trade. The differences are not just the result of the history of food safety regulations, often developed in times before global cooperation, but are also built in new regulations. It may be responses to media hypes or for other reasons, but in most cases the differences cannot be justified scientifically. A major difficulty is that, due to the developments in analytical techniques the number of chemicals that are found in food is increasing rapidly and chemicals are always suspected to be a safety risk. By far most chemicals are of natural origin but could not be detected in the past because the methods available in the past were not sensitive enough. Demanding the absence of chemicals because the risk they present is unknown, however, would eventually make all food unacceptable. The general public should be shown that everything they eat is chemical, and all food components will be toxic if the amount is too high. It should also be shown that many of these chemicals will also cause illness and death if there is not enough of it as is the case with vitamins and minerals.

  20. Modern Issues in Food Safety-A Perspective

    Institute of Scientific and Technical Information of China (English)

    James N Seiber

    2012-01-01

    INTRODUCTION There is much current interest worldwide in food safety.This results in large part from well publicized outbreaks due to foodborne pathogens,chemical food safety related to pesticides,and from persistent organic pollutants and other synthetic contaminants.Additionally,the melamine adulteration issue,acrylamide and other processing-induced toxicants in foods,petroleum hydrocarbons associated with oil spills in the oceans and seafood safety,mycotoxins and other natural contaminants in a variety of foods,and the perceived risks associated with foods improved by genetic modification or those protected by irradiation contribute to concerns over the safety of the food supply.

  1. 33 CFR Appendix A to Part 274 - Preventive Safety Measures in Handling of Pesticides

    Science.gov (United States)

    2010-07-01

    ... protective clothing are rubber aprons, coveralls, chemical splash goggles, safety shoes, and hard hats. A... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Preventive Safety Measures in... Appendix A to Part 274—Preventive Safety Measures in Handling of Pesticides 1. Follow the label on...

  2. 33 CFR Appendix E to Part 273 - Preventive Safety Measures in Handling of Herbicides

    Science.gov (United States)

    2010-07-01

    ... are rubber aprons, coveralls, chemical splash goggles, safety shoes and hard hats. A lightweight water... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Preventive Safety Measures in...—Preventive Safety Measures in Handling of Herbicides 1. Follow the label on each container before using...

  3. Formal Safety versus Real Safety: Quantitative and Qualitative Approaches to Safety Culture – Evidence from Estonia

    Directory of Open Access Journals (Sweden)

    Järvis Marina

    2016-10-01

    Full Text Available This paper examines differences between formal safety and real safety in Estonian small and medium-sized enterprises. The results reveal key issues in safety culture assessment. Statistical analysis of safety culture questionnaires showed many organisations with an outstanding safety culture and positive safety attitudes. However, qualitative data indicated some important safety weaknesses and aspects that should be included in the process of evaluation of safety culture in organisations.

  4. The Challenges for Food Safety in China

    OpenAIRE

    Yongmin, Bian

    2008-01-01

    After a long time fighting food shortages, China has been self-sufficient in food since 1995. But in the Action Plan on Food Safety published by China’s Ministry of Health (MOH) on August 14th 2003, the government classes the following current risks relevant to food safety in China as “very serious”: 1) Food-induced illnesses remain the supreme danger for public health; 2) New biological and chemical pollutants in food; 3) New food technologies and materials (such as transgenic food) raise ne...

  5. Pet Food Safety A Shared Concern

    Energy Technology Data Exchange (ETDEWEB)

    Buchanan, Robert L [University of Maryland; Baker, Robert C [Mars, Inc.; Charlton, Adrian J [UK Food and Environmental Research Agency, Sand Hutton, York, UK; Riviere, Jim E [North Carolina State University; Standaert, Robert F [ORNL

    2011-01-01

    The safety of the food supply is a subject of intense interest to consumers, particularly as a result of large scale outbreaks that involve hundreds and sometimes thousands of consumers. During the last decade this concern about food safety has expanded to include the diets of companion animals as a result of several incidences of chemical toxicities and infectious disease transmission. This has led to increased research into the causes and controls for these hazards for both companion animals and their owners. The following summary provides an introduction to the issues, challenges, and new tools being developed to ensure that commercial pet foods are both nutritious and safe.

  6. Pet food safety: a shared concern.

    Science.gov (United States)

    Buchanan, Robert L; Baker, Robert C; Charlton, Adrian J; Riviere, Jim E; Standaert, Robert

    2011-10-01

    The safety of the food supply is a subject of intense interest to consumers, particularly as a result of large-scale outbreaks that involve hundreds and sometimes thousands of consumers. During the last decade, this concern about food safety has expanded to include the diets of companion animals as a result of several incidences of chemical toxicities and infectious disease transmission. This has led to increased research into the causes and controls for these hazards for both companion animals and their owners. The following summary provides an introduction to the issues, challenges and new tools being developed to ensure that commercial pet foods are both nutritious and safe.

  7. Safety objectives for 2014

    CERN Multimedia

    HSE Unit

    2014-01-01

    This is the third year in which the CERN Management has presented annual safety objectives for the Organization, the “HSE Objectives”.   The HSE objectives for 2014, which were announced by the Director-General at his traditional New Year’s address to the staff and were presented at the first Enlarged Directorate meeting of the year, have been drawn up and agreed in close collaboration between the DSOs, the HSE Unit and the DG himself. From safety in the workplace to radiation and environmental protection, the document emphasises that “Safety is a priority for CERN” and that safety policy is a key element in how the Organization is run. And, like all policies, it generates objectives that “serve as a general framework for action”. The HSE objectives are broken down into the following fields: occupational health and safety on sites and in the workplace, radiation protection, radiation safety, environmental protection, emerge...

  8. Reliability and safety engineering

    CERN Document Server

    Verma, Ajit Kumar; Karanki, Durga Rao

    2016-01-01

    Reliability and safety are core issues that must be addressed throughout the life cycle of engineering systems. Reliability and Safety Engineering presents an overview of the basic concepts, together with simple and practical illustrations. The authors present reliability terminology in various engineering fields, viz.,electronics engineering, software engineering, mechanical engineering, structural engineering and power systems engineering. The book describes the latest applications in the area of probabilistic safety assessment, such as technical specification optimization, risk monitoring and risk informed in-service inspection. Reliability and safety studies must, inevitably, deal with uncertainty, so the book includes uncertainty propagation methods: Monte Carlo simulation, fuzzy arithmetic, Dempster-Shafer theory and probability bounds. Reliability and Safety Engineering also highlights advances in system reliability and safety assessment including dynamic system modeling and uncertainty management. Cas...

  9. Chemical thermodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Rock, P.A.

    1983-01-01

    This book, suitable as an introductory text for undergraduates, presents temperature, internal energy, and entropy with a minimum of mathematics. The basic mathematical models of classical chemical thermodynamics are developed later in the text. Includes numerous problems at the end of each chapter, an appendix giving thermodynamic data for common substances, a short list of references, answers to selected problems, and a subject index. Contents, abridged: Energy and the first law of thermodynamics. Thermodynamic functions. The third law of thermodynamics and absolute entropies. Thermodynamics of chemical reactions. Phase equilibria: the activity function. Thermodynamics of ions in solution. Statistical thermodynamics. Appendices. Index.

  10. TWRS safety management plan

    Energy Technology Data Exchange (ETDEWEB)

    Popielarczyk, R.S., Westinghouse Hanford

    1996-08-01

    The Tank Waste Remediation System (TWRS) Safety Management Program Plan for development, implementation and maintenance of the tank farm authorization basis is described. The plan includes activities and procedures for: (a) Updating the current Interim Safety Basis, (b) Development,implementation and maintenance of a Basis for Interim Operations, (c) Development, implementation and maintenance of the Final Safety Analyses Report, (d) Development and implementation of a TWRS information Management System for monitoring the authorization basis.

  11. Hydrogen Technologies Safety Guide

    Energy Technology Data Exchange (ETDEWEB)

    Rivkin, C. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Burgess, R. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Buttner, W. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-01-01

    The purpose of this guide is to provide basic background information on hydrogen technologies. It is intended to provide project developers, code officials, and other interested parties the background information to be able to put hydrogen safety in context. For example, code officials reviewing permit applications for hydrogen projects will get an understanding of the industrial history of hydrogen, basic safety concerns, and safety requirements.

  12. Food Safety & Standards

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ An increasing number of people have realized that food safety is an important issue for public health. It not only concerns public health and safety, but also has direct influence on national economic progress and social development. The development and implementation of food safety standards play a vital role in protecting public health, as well as in standardizing and facilitating the sound development of food production and business.

  13. Principles of electrical safety

    CERN Document Server

    Sutherland, Peter E

    2015-01-01

    Principles of Electrical Safety discusses current issues in electrical safety, which are accompanied by series' of practical applications that can be used by practicing professionals, graduate students, and researchers. .  Provides extensive introductions to important topics in electrical safety Comprehensive overview of inductance, resistance, and capacitance as applied to the human body Serves as a preparatory guide for today's practicing engineers

  14. Thermal reactor safety

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    Information is presented concerning new trends in licensing; seismic considerations and system structural behavior; TMI-2 risk assessment and thermal hydraulics; statistical assessment of potential accidents and verification of computational methods; issues with respect to improved safety; human factors in nuclear power plant operation; diagnostics and activities in support of recovery; LOCA transient analysis; unresolved safety issues and other safety considerations; and fission product transport.

  15. 煤化工企业泄压排放系统管网及其安全监控设计探讨(Ⅱ)%Research on the Design of Safety Monitoring for Pressure Relief and Discharge and Flare Torch System in Coal Chemical Industry Enterprises (Ⅰ)

    Institute of Scientific and Technical Information of China (English)

    胡平杰

    2011-01-01

    Based on the safety instrumentation design standard in petrochemical industry and the analysis of insufficiency and security hidden danger existed in the present coal chemical industry pressure relief discharge pipeline network, the safety supervisory control system for pressure relief discharge pipeline network by fully exerting the advanced morden instrument technology and DCS control technology has been designed. By monitoring parameters such as temperature, pressure, flowrate, differential presure of the torch main pipeline, the changes in those parameters can be judged. Through a set of mathematics and logic operations, DCS could give a interlock signal to trigger the interlock system of the torch main pipeline, to open the pressure relief valve, to ensure safe operation of the torch main pipeline.%结合石油化工安全仪表系统设计规范要求,在煤化工企业泄压排放系统和火炬系统设计存在的不足和安全隐患分析的基础上,充分发挥先进的现代仪表检测技术和DCS控制技术,设计了煤化工企业泄压排放系统和火炬系统的安全监控系统.通过监控火炬总管运行的温度、压力、差压、流量等基本参数,判断总管差压变化和温度、压力参数变化,各参数在DCS内完成一定的数学逻辑运算,发出火炬总管超压联锁信号,触发火炬总管超压联锁调节阀打开泄压,确保火炬总管安全运行.

  16. Bathroom safety - children

    Science.gov (United States)

    ... sure your child's daycare also follows these guidelines. Images Child safety References American Academy of Pediatrics: Committee on Injury, Violence, and Poison Prevention. Policy statement -- prevention of drowning. ...

  17. Light water reactor safety

    CERN Document Server

    Pershagen, B

    2013-01-01

    This book describes the principles and practices of reactor safety as applied to the design, regulation and operation of light water reactors, combining a historical approach with an up-to-date account of the safety, technology and operating experience of both pressurized water reactors and boiling water reactors. The introductory chapters set out the basic facts upon which the safety of light water reactors depend. The central section is devoted to the methods and results of safety analysis. The accidents at Three Mile Island and Chernobyl are reviewed and their implications for light wate

  18. Safety Study in Aviation

    OpenAIRE

    2016-01-01

    The objective of this article is to provide a brief look at safety studies, which are a necessary part of every change of system or a new system in aviation. The main focus is put on the area of air traffic management, because it affects most of the aviation stakeholders. The article begins with a description of safety and safety assessment of changes in systems. Then it discusses analysis of processes, hazard identification and risk assessment. Main part focuses on Safety studies and briefly...

  19. Lift truck safety review

    Energy Technology Data Exchange (ETDEWEB)

    Cadwallader, L.C.

    1997-03-01

    This report presents safety information about powered industrial trucks. The basic lift truck, the counterbalanced sit down rider truck, is the primary focus of the report. Lift truck engineering is briefly described, then a hazard analysis is performed on the lift truck. Case histories and accident statistics are also given. Rules and regulations about lift trucks, such as the US Occupational Safety an Health Administration laws and the Underwriter`s Laboratories standards, are discussed. Safety issues with lift trucks are reviewed, and lift truck safety and reliability are discussed. Some quantitative reliability values are given.

  20. Improved safety at CERN

    CERN Multimedia

    2006-01-01

    As announced in Weekly Bulletin No. 43/2006, a new approach to the implementation of Safety at CERN has been decided, which required taking some managerial decisions. The guidelines of the new approach are described in the document 'New approach to Safety implementation at CERN', which also summarizes the main managerial decisions I have taken to strengthen compliance with the CERN Safety policy and Rules. To this end I have also reviewed the mandates of the Safety Commission and the Safety Policy Committee (SAPOCO). Some details of the document 'Safety Policy at CERN' (also known as SAPOCO42) have been modified accordingly; its essential principles, unchanged, remain the basis for the safety policy of the Organisation. I would also like to inform you that I have appointed Dr M. Bona as the new Head of the Safety Commission until 31.12.2008, and that I will proceed soon to the appointment of the members of the new Safety Policy Committee. All members of the personnel are deemed to have taken note of the d...

  1. FOOD SAFETY TESTING LABORATORY

    Data.gov (United States)

    Federal Laboratory Consortium — This laboratory develops screening assays, tests and modifies biosensor equipment, and optimizes food safety testing protocols for the military and civilian sector...

  2. Training safely, Training safety

    Directory of Open Access Journals (Sweden)

    Jianjun Wu

    2014-09-01

    Full Text Available It is the basic requirement of maritime safety education to guarantee the safety of teaching operation while training the crew's occupation safety capability. Marine Training Center of Shanghai Maritime University has undertaken the practical teaching of "marine survival" for many years and come up with the whole safety procedures of training. Based on the requirements of SOLAS convention and regulations of STCW over crew training, this paper introduces the safety allocation, utilization and maintenance of teaching equipments. Through the investigation of the safety situation of students' practical operation, the safety teaching method named "four in one" has been put forward, which includes the pre-teaching safety precaution, the whole monitor during the teaching process, the post-teaching summary evaluation, and the reset and standby of teaching facilities. Finally, during the learning and training of "marine survival", crews and students are called on to place priority on personal safety rather than acquisition of knowledge and skills. Only in this way can they be capable of self-protection and protection of others in the career of seafaring.

  3. Chemical Mahjong

    Science.gov (United States)

    Cossairt, Travis J.; Grubbs, W. Tandy

    2011-01-01

    An open-access, Web-based mnemonic game is described whereby introductory chemistry knowledge is tested using mahjong solitaire game play. Several tile sets and board layouts are included that are themed upon different chemical topics. Introductory tile sets can be selected that prompt the player to match element names to symbols and metric…

  4. Chemical dispersants

    NARCIS (Netherlands)

    Rahsepar, Shokouhalsadat; Smit, Martijn P.J.; Murk, Albertinka J.; Rijnaarts, Huub H.M.; Langenhoff, Alette A.M.

    2016-01-01

    Chemical dispersants were used in response to the Deepwater Horizon oil spill in the Gulf of Mexico, both at the sea surface and the wellhead. Their effect on oil biodegradation is unclear, as studies showed both inhibition and enhancement. This study addresses the effect of Corexit on oil biodeg

  5. Chemical dispersants

    NARCIS (Netherlands)

    Rahsepar, Shokouhalsadat; Smit, Martijn P.J.; Murk, Albertinka J.; Rijnaarts, Huub H.M.; Langenhoff, Alette A.M.

    2016-01-01

    Chemical dispersants were used in response to the Deepwater Horizon oil spill in the Gulf of Mexico, both at the sea surface and the wellhead. Their effect on oil biodegradation is unclear, as studies showed both inhibition and enhancement. This study addresses the effect of Corexit on oil

  6. A Silent Safety Program

    Science.gov (United States)

    Goodin, James Ronald

    2006-01-01

    NASA's Columbia Accident Investigation Board (CAIB) referred 8 times to the NASA "Silent Safety Program." This term, "Silent Safety Program" was not an original observation but first appeared in the Rogers Commission's Investigation of the Challenger Mishap. The CAIB on page 183 of its report in the paragraph titled 'Encouraging Minority Opinion,' stated "The Naval Reactor Program encourages minority opinions and "bad news." Leaders continually emphasize that when no minority opinions are present, the responsibility for a thorough and critical examination falls to management. . . Board interviews revealed that it is difficult for minority and dissenting opinions to percolate up through the agency's hierarchy. . ." The first question and perhaps the only question is - what is a silent safety program? Well, a silent safety program may be the same as the dog that didn't bark in Sherlock Holmes' "Adventure of the Silver Blaze" because system safety should behave as a devil's advocate for the program barking on every occasion to insure a critical review inclusion. This paper evaluates the NASA safety program and provides suggestions to prevent the recurrence of the silent safety program alluded to in the Challenger Mishap Investigation. Specifically targeted in the CAM report, "The checks and balances the safety system was meant to provide were not working." A silent system safety program is not unique to NASA but could emerge in any and every organization. Principles developed by Irving Janis in his book, Groupthink, listed criteria used to evaluate an organization's cultural attributes that allows a silent safety program to evolve. If evidence validates Jams's criteria, then Jams's recommendations for preventing groupthink can also be used to improve a critical evaluation and thus prevent the development of a silent safety program.

  7. [Safety of food additives in Japan].

    Science.gov (United States)

    Ito, Sumio

    2011-01-01

    Recently, many accidents relating to food happened in Japan. The consumer's distrust for food, food companies, and the administration is increasing. The consumer especially has an extreme refusal feeling for chemicals such as food additives and agricultural chemicals, and begins to request agricultural chemical-free vegetables and food additive-free food. Food companies also state no agricultural chemicals and no food additives to correspond with consumers' request and aim at differentiating. The food additive is that the Ministry of Health, Labour and Welfare specifies the one that person's health might not be ruined by providing for Food Sanitation Law Article 10 in our country. The standard for food additives and standard for use of food additives are provided according to regulations of Food Sanitation Law Article 11. Therefore, it is thought that the food additive used is safe now. Then, it reports on the procedure and the safety examination, etc. in our country for designation for food additive this time.

  8. Mixed and low-level waste treatment project: Appendix C, Health and safety criteria for the mixed and low-level waste treatment facility at the Idaho National Engineering Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Neupauer, R.M.; Thurmond, S.M.

    1992-09-01

    This report contains health and safety information relating to the chemicals that have been identified in the mixed waste streams at the Waste Treatment Facility at the Idaho National Engineering Laboratory. Information is summarized in two summary sections--one for health considerations and one for safety considerations. Detailed health and safety information is presented in material safety data sheets (MSDSs) for each chemical.

  9. Safety Training: Basic Safety and Access Courses

    CERN Multimedia

    Antonella Vignes

    2005-01-01

    Objective The purpose of the basic safety courses is to increase awareness for everyone working on the CERN site (CERN staff, associates, outside companies, students and apprentices) of the various existing on-site hazards, and how to recognize and avoid them. Safety course changes The current organization for basic safety courses is changing. There will be two main modifications: the organization of the courses and the implementation of a specific new training course for the LHC machine during the LHC tests and hardware commissioning phase. Organizational changes This concerns the existing basic safety training, currently called level1, level2 and level3. Under the new procedure, a video will be projected in registration building 55 and will run every day at 14.00 and 15.00 in English. The duration of the video will be 50 minutes. The course contents will be the same as the slides currently used, plus a video showing real situations. With this new organization, attendees will systematically follow the...

  10. Safety Training: basic safety and access courses

    CERN Multimedia

    2005-01-01

    Objective The purpose of the basic safety courses is to increase awareness for everyone working on the CERN site (CERN staff, associates, outside companies, students and apprentices) of the various hazards existing on site, and how to recognise and avoid them. Safety course changes The current organisation of basic safety courses is changing. There will be two main modifications: the organisation of the courses and the implementation of a specific new training course for the LHC machine during the LHC tests and hardware commissioning phase. Organisational changes This concerns the existing basic safety training, currently called level 1, level 2 and level 3. Under the new procedure, a video will be projected in registration building 55 and will run every day at 14.00 and 15.00 in English. The duration of the video will be 50 minutes. The course contents will be the same as the slides currently used, plus a video showing real situations. With this new organization, participants will systematically follow...

  11. Radiological Safety Handbook.

    Science.gov (United States)

    Army Ordnance Center and School, Aberdeen Proving Ground, MD.

    Written to be used concurrently with the U.S. Army's Radiological Safety Course, this publication discusses the causes, sources, and detection of nuclear radiation. In addition, the transportation and disposal of radioactive materials are covered. The report also deals with the safety precautions to be observed when working with lasers, microwave…

  12. Safety Code A12

    CERN Multimedia

    SC Secretariat

    2005-01-01

    Please note that the Safety Code A12 (Code A12) entitled "THE SAFETY COMMISSION (SC)" is available on the web at the following url: https://edms.cern.ch/document/479423/LAST_RELEASED Paper copies can also be obtained from the SC Unit Secretariat, e-mail: sc.secretariat@cern.ch SC Secretariat

  13. Safety instruction no 50

    CERN Multimedia

    Secrétariat SC

    2004-01-01

    Please note that the safety instruction no 50 (IS 50) entitled 'Safety Coordination on CERN Worksites' is available on the web at the following url: https://edms.cern.ch/document/479454/LAST_RELEASED Paper copies can also be obtained from the SC unit Secretariat, email: sc.secretariat@cern.ch SC Secretariat

  14. Aviation safety and ICAO

    NARCIS (Netherlands)

    Huang, Jiefang

    2009-01-01

    The thesis addresses the issue of aviation safety under the rule of law. Aviation safety is a global concern. While air transport is considered a safe mode of travel, it is susceptible to inherent risks of flight, the use of force, and terrorist acts. Consequently, within the framework of the

  15. Nuclear safety in perspective

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, K. [Karinta-Konsult HB (Sweden); Sjoeberg, B.M.D. [Norwegian Univ. of Scince and Technology (Norway); Larudisen, K. [Risoe National Lab., Roskilde (Denmark); Wahlstroem, B. [VTT Automation (Finland)

    2002-06-01

    The aim of the NKS/SOS-1 project has been to enhance common understanding about requirements for nuclear safety by finding improved means of communicating on the subject in society. The project, which has been built around a number of seminars, was supported by limited research in three sub-projects: 1) Risk assessment, 2) Safety analysis, and 3) Strategies for safety management. The report describes an industry in change due to societal factors. The concepts of risk and safety, safety management and systems for regulatory oversight are described in the nuclear area and also, to widen the perspective, for other industrial areas. Transparency and public participation are described as key elements in good risk communication, and case studies are given. Environmental Impact Assessment and Strategic Environmental Assessment are described as important overall processes within which risk communication can take place. Safety culture, safety indicators and quality systems are important concepts in the nuclear safety area are very useful, but also offer important challenges for the future. They have been subject to special attention in the project. (au)

  16. Structural safety during construction

    NARCIS (Netherlands)

    Terwel, K.C.; Mud, M.; Frijters, A.

    2014-01-01

    Structural safety during construction is a main concern for the building industry. Collapses of temporary structures or incomplete permanent structures are a threat for the safety of persons. Based on data from Dutch Labour Inspectorate this study concluded that approximately 20% of the fatalities

  17. Roads to Safety.

    Science.gov (United States)

    Hauer, Ezra

    1991-01-01

    Contends that the level of safety built into roads is largely unpremeditated and that roads and highways are not as safe as they might be. Discusses practices, standards, and deficiencies in highway and traffic safety related to geometric design and traffic engineering. Recommends increased transportation engineering professionalism and public…

  18. Safety Behaviors and Stuttering

    Science.gov (United States)

    Lowe, Robyn; Helgadottir, Fjola; Menzies, Ross; Heard, Rob; O'Brian, Sue; Packman, Ann; Onslow, Mark

    2017-01-01

    Purpose: Those who are socially anxious may use safety behaviors during feared social interactions to prevent negative outcomes. Safety behaviors are associated with anxiety maintenance and poorer treatment outcomes because they prevent fear extinction. Social anxiety disorder is often comorbid with stuttering. Speech pathologists reported in a…

  19. Safety in Aquaculture

    Science.gov (United States)

    Durborow, Robert M.; Myers, Melvin L.

    2016-01-01

    In this article, occupational safety interventions for agriculture-related jobs, specifically in aquaculture, are reviewed. Maintaining quality of life and avoiding economic loss are two areas in which aquaculturists can benefit by incorporating safety protocols and interventions on their farms. The information in this article is based on farm…

  20. Subjective safety in traffic.

    NARCIS (Netherlands)

    2012-01-01

    The term ‘subjective safety in traffic’ refers to people feeling unsafe in traffic or, more generally, to anxiety regarding being unsafe in traffic for oneself and/or others. Subjective safety in traffic can lead to road users limiting their mobility and social activities, which is one of the

  1. Aviation safety and ICAO

    NARCIS (Netherlands)

    Huang, Jiefang

    2009-01-01

    The thesis addresses the issue of aviation safety under the rule of law. Aviation safety is a global concern. While air transport is considered a safe mode of travel, it is susceptible to inherent risks of flight, the use of force, and terrorist acts. Consequently, within the framework of the Intern

  2. Subjective safety in traffic.

    NARCIS (Netherlands)

    2012-01-01

    The term ‘subjective safety in traffic’ refers to people feeling unsafe in traffic or, more generally, to anxiety regarding being unsafe in traffic for oneself and/or others. Subjective safety in traffic can lead to road users limiting their mobility and social activities, which is one of the reason

  3. Elements of nuclear safety

    CERN Document Server

    Libmann, Jacques

    1996-01-01

    This basically educational book is intended for all involved in nuclear facility safety. It dissects the principles and experiences conducive to the adoption of attitudes compliant with what is now known as "safety culture". This book is accessible to a wide range of readers.

  4. Safety analysis for `Fugen`

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    The improvement of safety in nuclear power stations is an important proposition. Therefore also as to the safety evaluation, it is important to comprehensively and systematically execute it by referring to the operational experience and the new knowledge which is important for the safety throughout the period of use as well as before the construction and the start of operation of nuclear power stations. In this report, the results when the safety analysis for ``Fugen`` was carried out by referring to the newest technical knowledge are described. As the result, it was able to be confirmed that the safety of ``Fugen`` has been secured by the inherent safety and the facilities which were designed for securing the safety. The basic way of thinking on the safety analysis including the guidelines to be conformed to is mentioned. As to the abnormal transient change in operation and accidents, their definition, the events to be evaluated and the standards for judgement are reported. The matters which were taken in consideration at the time of the analysis are shown. The computation programs used for the analysis were REACT, HEATUP, LAYMON, FATRAC, SENHOR, LOTRAC, FLOOD and CONPOL. The analyses of the abnormal transient change in operation and accidents are reported on the causes, countermeasures, protective functions and results. (K.I.)

  5. A holistic view on Safety Management

    DEFF Research Database (Denmark)

    Jørgensen, Kirsten

    and supported by the UK Health and Safety Executive is developing a method for identifying major hazard safety barriers in the chemical industry and has been able to produce so called message maps of how to be aware of the barriers that must be in place and the role played by personnel, including managers......Abstract: Or a holistic view on prevention of accidents, which must be based on a well functioning management of safety. The major problem with accidents is that before they happened we believed everything was in order but only because nothing had happened up until then. The second problem...... is that risks are not present all the time and when the risk situation does occur then we are usually able to manage the situation and nothing happens. This makes us believe that we can handle the risky situations all the time. Jens Rasmussen expresses this in his “Drift to danger” concept (Ref). The only way...

  6. Second insulin pump safety meeting: summary report.

    Science.gov (United States)

    Zhang, Yi; Jones, Paul L; Klonoff, David C

    2010-03-01

    Diabetes Technology Society facilitated a second meeting of insulin pump experts at Mills-Peninsula Health Services, San Mateo, California on November 4, 2009, at the request of the Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories. The first such meeting was held in Bethesda, Maryland, on November 12, 2008. The group of physicians, nurses, diabetes educators, and engineers from across the United States discussed safety issues in insulin pump therapy and recommended adjustments to current insulin pump design and use to enhance overall safety. The meeting discussed safety issues in the context of pump operation; software; hardware; physical structure; electrical, biological, and chemical considerations; use; and environment from engineering, medical, nursing, and pump/user perspectives. There was consensus among meeting participants that insulin pump designs have made great progress in improving the quality of life of people with diabetes, but much more remains to be done.

  7. Chemical thermodynamics of americium

    Energy Technology Data Exchange (ETDEWEB)

    Silva, R.J. [California Univ., Livermore, CA (United States). Lawrence Livermore National Lab.; Bidoglio, G. [Commission of the European Communities, Ispra (Italy). Environment Inst.; Rand, M.H. [Wintershill Consultancy, Dry Sandford, Abingdon (United Kingdom); Robouch, P.B. [Commission of the European Communities, Geel (Belgium). Inst. for Reference Materials and Measurements; Wanner, H. [MBT Environmental Engineering, Zurich (Switzerland); Puigdomenech, I. [OECD Nuclear Energy Agency, Issy-les-Moulineaux (France)

    1995-09-01

    This is the second volume in a series of critical reviews of the chemical thermodynamic data of those elements of particular importance in the safety assessment modeling of high-level radioactive waste storage and disposal facilities. The objective of these reviews is to provide a set of reliable thermodynamic data that can be used to describe the behaviour of these elements under conditions relevant for radioactive waste disposal systems and the geochemical environments. The present volume is a review of experimental data reported in the literature for americium. On a few occasions, where no data existed, comparisons and estimates were made based on experimental data on analog lanthanide elements. The basic philosophy was to develop a minimum set of solid phases and solution species of americium that would fit all experimental data being reviewed. 15 figs., 32 tabs., 485 refs., 4 appendices

  8. Personnel Safety for Future Magnetic Fusion Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Lee Cadwallader

    2009-07-01

    The safety of personnel at existing fusion experiments is an important concern that requires diligence. Looking to the future, fusion experiments will continue to increase in power and operating time until steady state power plants are achieved; this causes increased concern for personnel safety. This paper addresses four important aspects of personnel safety in the present and extrapolates these aspects to future power plants. The four aspects are personnel exposure to ionizing radiation, chemicals, magnetic fields, and radiofrequency (RF) energy. Ionizing radiation safety is treated well for present and near-term experiments by the use of proven techniques from other nuclear endeavors. There is documentation that suggests decreasing the annual ionizing radiation exposure limits that have remained constant for several decades. Many chemicals are used in fusion research, for parts cleaning, as use as coolants, cooling water cleanliness control, lubrication, and other needs. In present fusion experiments, a typical chemical laboratory safety program, such as those instituted in most industrialized countries, is effective in protecting personnel from chemical exposures. As fusion facilities grow in complexity, the chemical safety program must transition from a laboratory scale to an industrial scale program that addresses chemical use in larger quantity. It is also noted that allowable chemical exposure concentrations for workers have decreased over time and, in some cases, now pose more stringent exposure limits than those for ionizing radiation. Allowable chemical exposure concentrations have been the fastest changing occupational exposure values in the last thirty years. The trend of more restrictive chemical exposure regulations is expected to continue into the future. Other issues of safety importance are magnetic field exposure and RF energy exposure. Magnetic field exposure limits are consensus values adopted as best practices for worker safety; a typical

  9. Medication safety in hospitals.

    Science.gov (United States)

    Kirke, C

    2009-01-01

    Medication error and adverse drug reactions occur frequently, leading to a high burden of patient harm in the hospital setting. Many Irish hospitals have established medication safety initiatives, designed to encourage reporting and learning to improve medication use processes and therefore patient safety. Eight Irish hospitals or hospital networks provided data from voluntary medication safety incident and near miss reporting programmes for pooled analysis of events occurring between 1st January 2006 and 30th June 2007. 6179 reports were received in total (mean 772 per hospital; range 96-1855). 95% of reports did not involve patient harm. Forty seven percent of reports related to the prescribing stage of the medication use process, 40% to the administration stage and 9% to the pharmacy dispensing stage. This data is published to increase awareness of this key patient safety issue, to share learning from these incidents and near misses and to encourage a more open patient safety culture.

  10. Formalizing Probabilistic Safety Claims

    Science.gov (United States)

    Herencia-Zapana, Heber; Hagen, George E.; Narkawicz, Anthony J.

    2011-01-01

    A safety claim for a system is a statement that the system, which is subject to hazardous conditions, satisfies a given set of properties. Following work by John Rushby and Bev Littlewood, this paper presents a mathematical framework that can be used to state and formally prove probabilistic safety claims. It also enables hazardous conditions, their uncertainties, and their interactions to be integrated into the safety claim. This framework provides a formal description of the probabilistic composition of an arbitrary number of hazardous conditions and their effects on system behavior. An example is given of a probabilistic safety claim for a conflict detection algorithm for aircraft in a 2D airspace. The motivation for developing this mathematical framework is that it can be used in an automated theorem prover to formally verify safety claims.

  11. Understanding Clinical Alarm Safety.

    Science.gov (United States)

    Lukasewicz, Carol L; Mattox, Elizabeth Andersson

    2015-08-01

    Patient safety organizations and health care accreditation agencies recognize the significance of clinical alarm hazards. The Association for the Advancement of Medical Instrumentation, a nonprofit organization focused on development and use of safe and effective medical equipment, identifies alarm management as a major issue for health care organizations. ECRI Institute, a nonprofit organization that researches approaches for improving patient safety and quality of care, identifies alarm hazards as the most significant of the "Top Ten Health Technology Hazards" for 2014. A new Joint Commission National Patient Safety Goal focusing on clinical alarm safety contains new requirements for accredited hospitals to be fully implemented by 2016. Through a fictional unfolding case study, this article reviews selected contributing factors to clinical alarm hazards present in inpatient, high-acuity settings. Understanding these factors improves contributions by nurses to clinical alarm safety practice.

  12. Hazardous chemical tracking system (HAZ-TRAC)

    Energy Technology Data Exchange (ETDEWEB)

    Bramlette, J D; Ewart, S M; Jones, C E

    1990-07-01

    Westinghouse Idaho Nuclear Company, Inc. (WINCO) developed and implemented a computerized hazardous chemical tracking system, referred to as Haz-Trac, for use at the Idaho Chemical Processing Plant (ICPP). Haz-Trac is designed to provide a means to improve the accuracy and reliability of chemical information, which enhances the overall quality and safety of ICPP operations. The system tracks all chemicals and chemical components from the time they enter the ICPP until the chemical changes form, is used, or becomes a waste. The system runs on a Hewlett-Packard (HP) 3000 Series 70 computer. The system is written in COBOL and uses VIEW/3000, TurboIMAGE/DBMS 3000, OMNIDEX, and SPEEDWARE. The HP 3000 may be accessed throughout the ICPP, and from remote locations, using data communication lines. Haz-Trac went into production in October, 1989. Currently, over 1910 chemicals and chemical components are tracked on the system. More than 2500 personnel hours were saved during the first six months of operation. Cost savings have been realized by reducing the time needed to collect and compile reporting information, identifying and disposing of unneeded chemicals, and eliminating duplicate inventories. Haz-Trac maintains information required by the Superfund Amendment Reauthorization Act (SARA), the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) and the Occupational Safety and Health Administration (OSHA).

  13. (Chemical thermodynamics)

    Energy Technology Data Exchange (ETDEWEB)

    Mesmer, R.E.

    1990-09-12

    The purpose of this travel was for the traveler to participate in the 11th IUPAC International Conference on Chemical Thermodynamics and to present a paper of which he is co-author entitled The Transition from Strong-to-Weak Electrolyte Behavior Near the Critical Point of Water'' in the session on Solutions. The conference brought together nearly 500 scientists from around the world to discuss broad aspects of experimental thermodynamics and theoretical modeling. The traveler also visited the University of Karlsruhe to discuss current research with E.U. Franck and his collaborators. This institution has been for many years one of the leading centers for experimental studies on phase equilibrium and physical chemical studies especially on pure substances under the direction of Franck.

  14. 4th annual Safety Day: full of colour!

    CERN Multimedia

    HSE Unit

    2014-01-01

    On Thursday 10 April, more than 240 people took part in the 4th annual Safety Day, organised on the occasion of the World Day for Safety and Health at Work. The HSE Unit, in partnership with the Fire Brigade (GS/FB) and the TE and BE Departments, organised various stands and activities connected with this year’s theme, chosen by the International Labour Organization: "Safety and health in the use of chemicals at work”.   The stands, set up at lunchtime in all three of CERN’s restaurants as well as in the entrance hall of Building 500, were designed to: Remind visitors of the need to use personal protective equipment appropriate to the chemicals they are using; Make visitors aware of the potential environmental impact of using chemicals; Encourage visitors to always read the labels and safety data sheets of dangerous chemicals and everyday domestic products; Inform visitors that a safety training course called “Chemical Risk Awareness&r...

  15. Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

    Science.gov (United States)

    Addressing the safety aspects of drugs and environmental chemicals has historically been undertaken through animal testing. However, the quantity of chemicals in need of assessment and the challenges of species extrapolation require the development of alternative approaches. Our ...

  16. Predicting Toxic and Therapeutic Mechanisms of the ToxCast Chemical Library by Phenotypic Screening (SOT)

    Science.gov (United States)

    Addressing safety aspects of drugs and environmental chemicals relies extensively on animal testing. However the quantity of chemicals needing assessment and challenges of species extrapolation require development of alternative approaches. Using 8 primary human cell systems (Bio...

  17. Revolution In Toxicity Testing And Risk Prediction For Chemicals In The Environment (ASA)

    Science.gov (United States)

    Addressing safety aspects of drugs and environmental chemicals relies extensively on animal testing; however, the quantity of chemicals needing assessment and challenges of species extrapolation require alternative approaches to traditional animal studies. Newer in vitro and in s...

  18. Revolution In Toxicity Testing And Risk Prediction For Chemicals In The Environment (ASA)

    Science.gov (United States)

    Addressing safety aspects of drugs and environmental chemicals relies extensively on animal testing; however, the quantity of chemicals needing assessment and challenges of species extrapolation require alternative approaches to traditional animal studies. Newer in vitro and in s...

  19. FOOD SAFETY REGULATIONS BASED ON REAL SCIENCE

    OpenAIRE

    2015-01-01

    Differences in regulations result in needless destruction of safe food and hamper food trade. The differences are not just the result of the history of food safety regulations, often developed in times before global cooperation, but are also built in new regulations. It may be responses to media hypes or for other reasons, but in most cases the differences cannot be justified scientifically. A major difficulty is that, due to the developments in analytical techniques the number of chemicals t...

  20. Loose Regulation Worsens Food Safety Problem

    Institute of Scientific and Technical Information of China (English)

    Economic Weekly

    2011-01-01

    @@ Do not misunderstand food additives From milk powder tainted with melamine to hams with clen-buterol to beef extract with amino acids, food safety issues are a growing concern among the public.These chemical terms became catch words only because they are adulterated in the most often eaten food.Food additives are now synony mous with pursuit of profit, offense against the law, and even poison.