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Sample records for chemical body burdens

  1. From body burden to effective dose equivalent

    International Nuclear Information System (INIS)

    The necessary data to calculate the effective committed dose equivalent and the effective dose-equivalent rate from measured body burdens are presented. Both ingestion and inhalation intakes are considered, for single intake as well as for continuous exposure

  2. Radiocesium body burdens in northern Canadians

    International Nuclear Information System (INIS)

    Whole body measurements were carried out on 1117 Canadians living in five Arctic communities during 1989 and 1990 in order to assess the uptake of radiocesium, from the lichen-caribou-human food chain. The Cs-137 body burdens increased with age, and were twice as high for men as for women. There was a discrepancy between the reported meat consumption and the measured body burdens. Average radiation doses from ingested radiocesium varied from 0.01 to 0.10 mSv/a. (author)

  3. Comparison of organochlorine chemical body burdens of female breast cancer cases with cancer free women in Rio Grande do Sul, Brazil--Pilot Study

    Energy Technology Data Exchange (ETDEWEB)

    Erdmann, C.A.; Petreas, M.X.; Caleffi, M.; Barbosa, F.S.; Goth-Goldstein, R.

    1999-12-01

    This pilot study collected preliminary data to examine known and suspected breast cancer risk factors among women living in rural and urban areas in the state of Rio Grande do Sul, Brazil by questionnaire. In addition, the body burden levels of a panel of organochlorines was measured in a small clinic-based prospective sample.

  4. From body burden to effective dose equivalent. Part 2

    International Nuclear Information System (INIS)

    A compact set of data is presented for the evaluation of measurements performed with a whole body counter. For each nuclide the following information is collected: physical halflife; metabolic data; the relation between chemical compound and inhalation class; the fraction of intake in the human body at 18 points in time after a single intake; the relation between intake and effective committed dose equivalent; the equilibrium body burden following continuous intake; the relation between a constant body burden and dose-equivalent rate. This report is an extension of an earlier paper (ECN-116). It completes the list of nuclides, i.e. apart from noble gas nuclides almost all nuclides with a physical halflife exceeding 12 hours have been considered, either in this paper or in part I. (Auth.)

  5. Interaction of ethanol and mercury body burden in the mouse

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, J.D.

    1978-01-01

    The interaction of ethanol with mercury in the body resulting in increased exhalation of the metal was studied in the mouse. A persistent elimination of the metal in the breath was demonstrated after single, sublethal (<1 mgHg/Kg body weight) exposures to mercury vapor (Hg/sup 0/) or mercury II chloride (HgCl/sub 2/). The amount of mercury exhaled per unit time was enhanced by oral or parenteral administration of ethanol solutions. These modifications were investigated in dose-response studies in which the drug was administered in doses ranging from 0.2g to 5.5g/Kg to mice pretreated with mercury. The EC/sub 50/ for blood ethanol with respect to mercury exhalation was determined to be approximately 200 mg/dl corresponding to an output rate of approximately 0.1% of the simultaneous body burden in 30 min several days after mercury. A hypothesis that mercury expired by these animals was proportional to the body burden after mercury administration was addressed in experiments whereby mice given one of several doses of mercuric chloride (0.16 to 500 ..mu..g/Kg) were monitored for pulmonary mercury elimination for a fifteen day period. The high correlation obtained between the amount of mercury exhaled in a standard time period and the body burden by group indicated that breath sampling could be applied as an indicator of the mercury body burden which may not be limited to the mouse.

  6. An in vivo animal study assessing long-term changes in hypothalamic cytokines following perinatal exposure to a chemical mixture based on Arctic maternal body burden

    Directory of Open Access Journals (Sweden)

    Li Nanqin

    2011-07-01

    Full Text Available Abstract Background The geographic distribution of environmental toxins is generally not uniform, with certain northern regions showing a particularly high concentration of pesticides, heavy metals and persistent organic pollutants. For instance, Northern Canadians are exposed to high levels of persistent organic pollutants like polychlorinated biphenyls (PCB, organochlorine pesticides (OCs and methylmercury (MeHg, primarily through country foods. Previous studies have reported associations between neuronal pathology and exposure to such toxins. The present investigation assessed whether perinatal exposure (gestation and lactation of rats to a chemical mixture (27 constituents comprised of PCBs, OCs and MeHg based on Arctic maternal exposure profiles at concentrations near human exposure levels, would affect brain levels of several inflammatory cytokines Methods Rats were dosed during gestation and lactation and cytokine levels were measured in the brains of offspring at five months of age. Hypothalamic cytokine protein levels were measured with a suspension-based array system and differences were determined using ANOVA and post hoc statistical tests. Results The early life PCB treatment alone significantly elevated hypothalamic interleukin-6 (IL-6 levels in rats at five months of age to a degree comparable to that of the entire chemical mixture. Similarly, the full mixture (and to a lesser degree PCBs alone elevated levels of the pro-inflammatory cytokine, IL-1b, as well as the anti-inflammatory cytokine, IL-10. The full mixture of chemicals also moderately increased (in an additive fashion hypothalamic levels of the pro-inflammatory cytokines, IL-12 and tumor necrosis factor (TNF-α. Challenge with bacterial endotoxin at adulthood generally increased hypothalamic levels to such a degree that differences between the perinatally treated chemical groups were no longer detectable. Conclusions These data suggest that exposure at critical

  7. Sampling and Analysis for Assessment of Body Burdens

    International Nuclear Information System (INIS)

    A review of sampling criteria and techniques and of sample processing methods for indirect assessment of body burdens is presented. The text is limited to the more recent developments in the field of bioassay and to the nuclides which cannot be readily determined in the body directly. A selected bibliography is included. The planning of a bioassay programme should emphasize the detection of high or unusual exposures and the concentrated study of these cases when detected. This procedure gives the maximum amount of data for the dosimetry of individuals at risk and also adds to our scientific background for an understanding of internal emitters. Only a minimum of effort should be spent on sampling individuals having had negligible exposure. The chemical separation procedures required for bioassay also fall into two categories. The first is the rapid method, possibly of low accuracy, used for detection. The second is the more accurate method required for study of the individual after detection of the exposure. Excretion, whether exponential or a power function, drops off rapidly. It is necessary to locate the exposure in time before any evaluation can be made, even before deciding if the exposure is significant. One approach is frequent sampling and analysis by a quick screening technique. More commonly, samples are collected at longer intervals and an arbitrary level of re-sampling is set to assist in the detection of real exposures. It is probable that too much bioassay effort has gone into measurements on individuals at low risk and not enough on those at higher risk. The development of bioassay procedures for overcoming this problem has begun, and this paper emphasizes this facet of sampling and sample processing. (author)

  8. Inhalation exposure or body burden? Better way of estimating risk--An application of PBPK model.

    Science.gov (United States)

    Majumdar, Dipanjali; Dutta, Chirasree; Sen, Subha

    2016-01-01

    We aim to establish a new way for estimating the risk from internal dose or body burden due to exposure of benzene in human subject utilizing physiologically based pharmacokinetic (PBPK) model. We also intend to verify its applicability on human subjects exposed to different levels of benzene. We estimated personal inhalation exposure of benzene for two occupational groups namely petrol pump workers and car drivers with respect to a control group, only environmentally exposed. Benzene in personal air was pre-concentrated on charcoal followed by chemical desorption and analysis by gas chromatography equipped with flame ionization detector (GC-FID). We selected urinary trans,trans-muconic acid (t,t-MA) as biomarker of benzene exposure and measured its concentration using solid phase extraction followed by high performance liquid chromatography (HPLC). Our estimated inhalation exposure of benzene was 137.5, 97.9 and 38.7 μg/m(3) for petrol pump workers, car drivers and environmentally exposed control groups respectively which resulted in urinary t,t-MA levels of 145.4±55.3, 112.6±63.5 and 60.0±34.9 μg g(-1) of creatinine, for the groups in the same order. We deduced a derivation for estimation of body burden from urinary metabolite concentration using PBPK model. Estimation of the internal dose or body burden of benzene in human subject has been made for the first time by the measurement of t,t-MA as a urinary metabolite using physiologically based pharmacokinetic (PBPK) model as a tool. The weight adjusted total body burden of benzene was estimated to be 17.6, 11.1 and 5.0 μg kg(-1) of body weight for petrol pump workers, drivers and the environmentally exposed control group, respectively using this method. We computed the carcinogenic risk using both the estimated internal benzene body burden and external exposure values using conventional method. Our study result shows that internal dose or body burden is not proportional to level of exposure rather have a

  9. On the Estimation of a Systemic Body Burden of Plutonium

    International Nuclear Information System (INIS)

    Several computer programmes have been described in the literature which use the complete urinalysis record of employees to estimate their systemic body burden of plutonium 239, i.e. the body burden exclusive of plutonium 239 in the lungs or in the contents of the gastro-intestinal tract. For each successive sample date such codes use an excretion model, suggested by Langham, to estimate the urinary excretion that would be expected to result from prior intakes that have been estimated. Any excess in the sample is considered to indicate an additional intake, or is rejected as being the result of an erroneous determination. An examination of excretion data taken under controlled conditions indicates that there is considerable fluctuation about the smoothed curves used in the excretion model, that the deviations are by less than a factor of two in the majority of cases, and that much of this fluctuation must be accepted as of biological origin and not merely the result of faulty sampling techniques. This suggests that a mathematical treatment should accept small fluctuations as not necessarily indicating additional exposure or artifacts of sampling. Such a computer code has been written and tested on the few cases where the body burden is considered to be well established. These cases suggest that this technique may be an improvement over earlier methods. The code uses one index as specifying a level below which data are not considered to be significant, and a second index specifies the degree of excess over the general trend which is considered to be due to additional intake to blood. (author)

  10. Evaluation of modelling body burden of Cs-137

    International Nuclear Information System (INIS)

    Within the IAEA/CEC VAMP-program one working group studied the precision in dose assessment models when calculating body burden of 137Cs as a result of exposure through multiple exposure pathways. One scenario used data from southern Finland regarding contamination of various media due to the fallout from the Chernobyl accident. In this study, a time dependent multiple exposure pathway model was constructed based on compartment theory. Uncertainties in model responses due to uncertainties in input parameter values were studied. The initial predictions for body burden were good, within a factor of 2 of the observed, while the time dynamics of levels in milk and meat did not agree satisfactorily. Some results, nevertheless, showed good agreement with observations due to compensatory effects. After disclosure of additional observational data, major reasons for mispredictions were identified as lack of consideration of time dependence of fixation of 137Cs in soils, and the selection of parameter values. When correction of this was made, a close agreement between predictions and observations was obtained. This study shows that the dose contribution due to 137Cs in food products from the seminatural environment is important for long-term exposure to man. The evaluation provided a basis for improvements of crucial parts in the model. 14 refs, 18 figs, 8 tabs

  11. Physiological Properties of Plutonium and Assessment of Body Burden in Man

    International Nuclear Information System (INIS)

    Twenty years have elapsed since enough plutonium became available to create a potential industrial health problem. Subsequent human experience and animal experimentation show that, of the three principal modes of exposure (inhalation, ingestion and skin absorption), inhalation is the most important. Deposition, elimination, absorption and tissue distribution of inspired plutonium are strongly dependent on chemical form, particle size, exposure procedure and animal species, resulting in quantitative exceptions to any generalized model as to disposition and fate of inhaled plutonium. Exposure via ingestion is of little Importance; gut absorption Is about 0.002%/h of the ingested dose. Absorption through unbroken skin is less than 0.0002% of contact. Contaminated wounds (second only to inhalation as a potential industrial medical problem) result in slow absorption into the circulation, contributing to a systemic burden and producing chronic radiation changes at the site of implant. Tissue distribution of plutonium is dependent on mode of exposure, chemical form, particle size and colloidal aggregation. Presently the only routine method of assessing plutonium body burden is to relate urinary excretion to body burden through the expression D = 435 Ut-0.76, where D is body burden, U is daily output in urine, both in the same units, and t is time (in days) following exposure. This empirical relationship was established in a limited number of terminal human subjects following a single intravenous injection of a small amount of Pu+4-citrate. Two computer methods have been developed to relate excretion rate under chronic exposure conditions to body burden on the basis of the above expression. Validity of these methods has not been proven. Although improved methods of urine analysis have been developed, no improvement in the basic expression or its applicability to exposure conditions more closely approaching those encountered in practice has been produced. No procedure

  12. Body burdens of heavy metals in Lake Michigan wetland turtles.

    Science.gov (United States)

    Smith, Dayna L; Cooper, Matthew J; Kosiara, Jessica M; Lamberti, Gary A

    2016-02-01

    Tissue heavy metal concentrations in painted (Chrysemys picta) and snapping (Chelydra serpentina) turtles from Lake Michigan coastal wetlands were analyzed to determine (1) whether turtles accumulated heavy metals, (2) if tissue metal concentrations were related to environmental metal concentrations, and (3) the potential for non-lethal sampling techniques to be used for monitoring heavy metal body burdens in freshwater turtles. Muscle, liver, shell, and claw samples were collected from painted and snapping turtles and analyzed for cadmium, chromium, copper, iron, lead, magnesium, manganese, and zinc. Turtle tissues had measurable quantities of all eight metals analyzed. Statistically significant correlations between tissue metal concentrations and sediment metal concentrations were found for a subset of metals. Metals were generally found in higher concentrations in the larger snapping turtles than in painted turtles. In addition, non-lethal samples of shell and claw were found to be possible alternatives to lethal liver and muscle samples for some metals. Human consumption of snapping turtles presents potential health risks if turtles are harvested from contaminated areas. Overall, our results suggest that turtles could be a valuable component of contaminant monitoring programs for wetland ecosystems. PMID:26832725

  13. Quantitative Assessment of Whole-Body Tumor Burden in Adult Patients with Neurofibromatosis

    OpenAIRE

    Plotkin, Scott R.; Bredella, Miriam A.; Cai, Wenli; Kassarjian, Ara; Harris, Gordon J.; Esparza, Sonia; Vanessa L Merker; Munn, Lance L; Muzikansky, Alona; Askenazi, Manor; Nguyen, Rosa; Wenzel, Ralph; Mautner, Victor F.

    2012-01-01

    Purpose Patients with neurofibromatosis 1 (NF1), NF2, and schwannomatosis are at risk for multiple nerve sheath tumors and premature mortality. Traditional magnetic resonance imaging (MRI) has limited ability to assess disease burden accurately. The aim of this study was to establish an international cohort of patients with quantified whole-body internal tumor burden and to correlate tumor burden with clinical features of disease. Methods We determined the number, volume, and distribution of ...

  14. National Status and Trends: Contaminant body burdens and histopathology of fish and shellfish from Alaska

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — In response to the growing concerns among Chugach communities, contaminant body burden and histopathological condition of chum and sockeye salmon (Oncorhynchus keta...

  15. Body burden and distribution of 137Cs in reindeer

    International Nuclear Information System (INIS)

    The whole body was collected from 6 reindeer that had been grazing contaminated pasture and from 6 reindeer that had been fed uncontaminated feed the last weeks before slaughter. The body was emptied from in-gesta and weighed. Samples were taken from skeletal muscle, kidneys, heart, liver, lungs, rumen wall, bone and blood. The total activity of 137Cs in the ingesta-free body and the activity concentration of l37Cs in the different tissues were determined. The highest acitivity concentrations of l37Cs were found in skeletal muscle and in kidneys. Activity concentrations in kidneys, heart, liver, lungs and rumen wall, relative to skeletal muscle, were lower in reindeer with decreasing radiocaesium levels, compared to reindeer with continuous intake of radiocaesium, indicating a more rapid elimination in these tissues than in muscle. The ratios between average activity concentration of 137Cs in whole body and acitivity concentration in muscle from the same animal, ranged from 0.51 to 0.62. A factor of 0.57 is suggested for calculating average body activity concentration of radiocaesium from known activity concentration in muscle

  16. Research With A View To Estimating The Body Burden Of Rare Earths On The Basis Of Excreta Measurements

    International Nuclear Information System (INIS)

    Body burden can be estimated directly from excreta measurements only if the chemical nature of the element involved is the sole factor governing distribution and rates of exchange in the body. Many authors have already called attention to the way in which metabolism and elimination rates are affected by various parameters, such as the nature of the anionic radical, the valency of the element, the physico-chemical state of the contaminating form and the channel and manner of contamination. The authors show that these factors mainly affect the initial kinetics of distribution in the body during the very first minutes. Using high-speed recording techniques and varying several experimental parameters, they studied the effect of these parameters on initial kinetics, the subsequent evolution of contamination in the various tissues and elimination processes. In particular, they recorded the kinetics of bile and urine elimination, blood purification and the radioactivity level of various organs (liver, kidneys, lungs). In order to relate the body burden to the quantities of radioisotope eliminated, it is necessary to know the amounts present in the various compartments, their rates of exchange and the times required for elimination by the various channels. In an attempt to clarify these points, the authors devised a test using a chelating agent which modifies the equilibria between compartments and directs all available cerium towards the elimination channels. By comparing the elimination values measured before and during the test, they attempt to calculate the total body burden and its distribution. They also discuss ways of applying this test at various stages in contamination. (author)

  17. Chromosome breakage in lymphocytes from humans with body burdens of 226Ra

    International Nuclear Information System (INIS)

    Peripheral lymphocytes from 10 controls and 40 patients with body burdens of 226Ra ranging from below the limit of detection to 8.6 μCi were scored for unstable chromosome aberrations. The patient population was divided into four groups: a group with body burdens below the limit of detection (less than 0.003 μCi, 12 patients); a low-burden group (0.003 to 0.099 μCi, 13 patients); a moderate-burden group (0.1 to 0.99 μCi, 11 patients); and a high-burden group (greater than 1.0 μCi, 4 patients). In none of these groups was the frequency of cells with unstable aberrations significantly elevated above that in the controls. The rate of occurrence of dicentric and ring chromosomes was above the control frequency in only the two patients with the highest burdens (3.55 and 8.6 μCi). Our results are consistent with the expectation derived from a recent calculation of alpha dose delivered to blood by bone-deposited radium and its decay products. Marshall and Hoegerman have estimated that the blood dose for an individual with a radium burden of 1.0 μCi is 0.09 +- 0.03 rad/year. The value is compared with the dose estimate used by Boyd et al. in their study of British radium-dial painters, and the relevance of the blood dose to the lymphocyte dose is discussed

  18. Survival, reproduction, and arsenic body burdens in Chironomus riparius exposed to arsenate and phosphate

    Energy Technology Data Exchange (ETDEWEB)

    Mogren, Christina L., E-mail: christina.mogren@email.ucr.edu [Department of Entomology, University of California, Riverside, 900 University Ave, Riverside, CA 92521 (United States); Kiparski, Guntram R. von; Parker, David R. [Department of Environmental Science, University of California, Riverside, 900 University Ave, Riverside, CA 92521 (United States); Trumble, John T. [Department of Entomology, University of California, Riverside, 900 University Ave, Riverside, CA 92521 (United States)

    2012-05-15

    Despite the increasing awareness of arsenic (As) contamination in surface waters worldwide, little is known about how As alone and in the presence of other chemicals affects aquatic insects. Larvae of Chironomus riparius were exposed in a laboratory investigation to factorial combinations of 0, 0.13, 2.0, 5.3, and 13 {mu}mol As l{sup -1} and 0, 0.15, and 15 {mu}mol PO{sub 4} l{sup -1} throughout development from first instar to pupal emergence. The time between male and female emergence increased from 1.8 {+-} 0.17 days to 2.9 {+-} 0.34 days with exposure at higher As levels. The highest As exposure also decreased the number of eggs per egg mass, which may affect population maintenance. For these parameters, there was no effect from PO{sub 4}, and no interaction between As and PO{sub 4}. Total As determination of larval and adult tissues was conducted using Hydride Generated Atomic Absorption Spectroscopy (HGAAS) and revealed concentrations ranging from 2.48 {+-} 0.363 to 30.5 {+-} 0.473 {mu}g/g and 1.03 {+-} 0.286 to 8.97 {+-} 0.662 {mu}g/g, respectively, indicating elimination of approximately 72% of total As body burdens between the fourth instar and adult stages. There was no effect of PO{sub 4}, indicating PO{sub 4} does not alter uptake of As in C. riparius. The potential for movement of As to terrestrial systems exists, though trophic transfer may be more likely during the aquatic larval stage. - Highlights: Black-Right-Pointing-Pointer We evaluate how sublethal concentrations of As and P affect C. riparius. Black-Right-Pointing-Pointer High As exposure significantly increased the time between male and female emergence. Black-Right-Pointing-Pointer High As exposure significantly decreased the number of eggs per egg mass. Black-Right-Pointing-Pointer Fourth instar larvae eliminate 72% of As body burdens before the adult stage.

  19. Knowns and unknowns on burden of disease due to chemicals: a systematic review

    Directory of Open Access Journals (Sweden)

    Bertollini Roberto

    2011-01-01

    Full Text Available Abstract Background Continuous exposure to many chemicals, including through air, water, food, or other media and products results in health impacts which have been well assessed, however little is known about the total disease burden related to chemicals. This is important to know for overall policy actions and priorities. In this article the known burden related to selected chemicals or their mixtures, main data gaps, and the link to public health policy are reviewed. Methods A systematic review of the literature for global burden of disease estimates from chemicals was conducted. Global disease due to chemicals was estimated using standard methodology of the Global Burden of Disease. Results In total, 4.9 million deaths (8.3% of total and 86 million Disability-Adjusted Life Years (DALYs (5.7% of total were attributable to environmental exposure and management of selected chemicals in 2004. The largest contributors include indoor smoke from solid fuel use, outdoor air pollution and second-hand smoke, with 2.0, 1.2 and 0.6 million deaths annually. These are followed by occupational particulates, chemicals involved in acute poisonings, and pesticides involved in self-poisonings, with 375,000, 240,000 and 186,000 annual deaths, respectively. Conclusions The known burden due to chemicals is considerable. This information supports decision-making in programmes having a role to play in reducing human exposure to toxic chemicals. These figures present only a number of chemicals for which data are available, therefore, they are more likely an underestimate of the actual burden. Chemicals with known health effects, such as dioxins, cadmium, mercury or chronic exposure to pesticides could not be included in this article due to incomplete data and information. Effective public health interventions are known to manage chemicals and limit their public health impacts and should be implemented at national and international levels.

  20. Evaluation of radium-226 body burden by in vivo measurement of bismuth-214

    International Nuclear Information System (INIS)

    An indirect method of estimation of radium-226 body burden has been developed to overcome the difficulties of direct measurement of radium on account of low emission of 186 KeV gamma radiation that too in a region where the background count rate is high. The method is based on in vivo measurement of sup(214)Bi content of the body by a shadow shield whole body counter [102 mm (dia) x 76 mm (thick) NaI(Tl) detector]. sup(214)Bi emits gamma rays of 0.609, 1.120 and 1.764 MeV of which the last one is suitable for whole body counting because in that energy region there is no contribution from naturally occurring radioisotopes in the body (e.g. sup(40)K) and the response is independent of variation in body build. The ratio of the minimum detectable radium body burden for the whole body monitor at Jaduguda uranium mines using the indirect and direct methods for the same counting periods works out to be 0.85, indicating that the indirect method is somewhat superior to the direct method. (M.G.B.)

  1. Arsenic body- burden in coronary heart disease cases of West Bengal, India.

    Directory of Open Access Journals (Sweden)

    De Auley, Haldar Ajanta, Podder Gargi, Adhikari Aniket, Ray Saumitra, Banerjee Jayshree, De Madhusnata

    2013-01-01

    Full Text Available Background: Coronary Heart Disease is a big concern for the health of the residents of India. Environmental contaminants, air pollutants, synthetic chemicals, and the mineral content in drinking water can affect the heart by altering the heart rate, contractility and excitability of heart muscle or by causing atherosclerosis. Objective: The aim of this study is to observe the level of arsenic exposure and clastogeniceffect of arsenic in coronary heart disease cases of West Bengal. Methods: A total 511 cases were screened. Our study group included 100 nos of coronary heart disease cases and 70 no of healthy controls from West Bengal. Multivariate Logistic Regression and Student’s t - test was used for statistical analysis of the parameters. The clastogenic effect of Arsenic was also examined by performing Cytogenetic Analysis. Results: Multivariate logistic regression analysis has revealed that a patient’s age, Low density lipoprotein level and hypertension played a significant role in the development of CHD. Hair arsenic level in CHD cases (0.7±0.2 µg/kg was significantly high (p<0.01 than that of the controls (0.20±0.09 µg/kg. Mitotic index (4.4±0.21 was significantly low (p≤0. 05 and chromosomal aberration (0.61±0.13 was significantly higher (p≤0. 005 in CHD cases. Conclusion: This study has revealed the facts that age, low density lipoprotein level, hypertension are the three significant risk factors of CHD. It was found that, the hair arsenic content of the CHD cases in this region was having the arsenic body burden. Clastogenic effect of arsenic on coronary heart disease cases.

  2. Quantitative assessment of whole-body tumor burden in adult patients with neurofibromatosis.

    Directory of Open Access Journals (Sweden)

    Scott R Plotkin

    Full Text Available PURPOSE: Patients with neurofibromatosis 1 (NF1, NF2, and schwannomatosis are at risk for multiple nerve sheath tumors and premature mortality. Traditional magnetic resonance imaging (MRI has limited ability to assess disease burden accurately. The aim of this study was to establish an international cohort of patients with quantified whole-body internal tumor burden and to correlate tumor burden with clinical features of disease. METHODS: We determined the number, volume, and distribution of internal nerve sheath tumors in patients using whole-body MRI (WBMRI and three-dimensional computerized volumetry. We quantified the distribution of tumor volume across body regions and used unsupervised cluster analysis to group patients based on tumor distribution. We correlated the presence and volume of internal tumors with disease-related and demographic factors. RESULTS: WBMRI identified 1286 tumors in 145/247 patients (59%. Schwannomatosis patients had the highest prevalence of tumors (P = 0.03, but NF1 patients had the highest median tumor volume (P = 0.02. Tumor volume was unevenly distributed across body regions with overrepresentation of the head/neck and pelvis. Risk factors for internal nerve sheath tumors included decreasing numbers of café-au-lait macules in NF1 patients (P = 0.003 and history of skeletal abnormalities in NF2 patients (P = 0.09. Risk factors for higher tumor volume included female gender (P = 0.05 and increasing subcutaneous neurofibromas (P = 0.03 in NF1 patients, absence of cutaneous schwannomas in NF2 patients (P = 0.06, and increasing age in schwannomatosis patients (p = 0.10. CONCLUSION: WBMRI provides a comprehensive phenotype of neurofibromatosis patients, identifies distinct anatomic subgroups, and provides the basis for investigating molecular biomarkers that correlate with unique disease manifestations.

  3. Influence of parasitism in controlling the health, reproduction and PAH body burden of petroleum seep mussels

    Science.gov (United States)

    Powell, Eric N.; Barber, Robert D.; Kennicutt, Mahlon C., II; Ford, Susan E.

    1999-12-01

    Petroleum seep mussels are often exposed to high hydrocarbon concentrations in their natural habitat and, thus, offer the opportunity to examine the relationship between parasitism, disease and contaminant exposure under natural conditions. This is the first report on the histopathology of cold-seep mussels. Seep mussels were collected by submersible from four primary sites in the Gulf of Mexico, lease blocks Green Canyon (GC) 184, GC-234, GC-233, and Garden Banks 425 in 550-650 m water depth. Five types of parasites were identified in section: (1) gill "rosettes" of unknown affinity associated with the gill bacteriocytes, (2) gill "inclusions" similar to chlamydia/rickettsia inclusions, (3) extracellular gill ciliates, (4) body "inclusions" that also resemble chlamydial/rickettsial inclusions, and (5) Bucephalus-like trematodes. Comparison to shallow-water mytilids demonstrates that: (1) both have similar parasite faunas; (2) seep mytilids are relatively heavily parasitized; and (3) infection intensities are extremely high in comparison to shallow-water mytilids for Bucephalus and chlamydia/rickettsia. In this study, the lowest prevalence for chlamydia/rickettsia was 67%. Prevalences of 100% were recorded from three populations. Bucephalus prevalence was ⩾70% in three of 10 populations. The parasite fauna was highly variable between populations. Some important parasites were not observed in some primary sites. Even within primary sites, some important parasites were not observed in some populations. Bucephalus may exert a significant influence on seep mussel population dynamics. Forty percent of the populations in this study are severely reproductively compromised by Bucephalus infection. Only a fraction of petroleum seep mussel populations are maintaining the entire beta-level population structure of this species. Variation in two parasites, gill ciliates and Bucephalus, explained most of the variation in PAH body burden between mussel populations. PAHs are

  4. Relationships between host body condition and immunocompetence, not host sex, best predict parasite burden in a bat-helminth system.

    Science.gov (United States)

    Warburton, Elizabeth M; Pearl, Christopher A; Vonhof, Maarten J

    2016-06-01

    Sex-biased parasitism highlights potentially divergent approaches to parasite resistance resulting in differing energetic trade-offs for males and females; however, trade-offs between immunity and self-maintenance could also depend on host body condition. We investigated these relationships in the big brown bat, Eptesicus fuscus, to determine if host sex or body condition better predicted parasite resistance, if testosterone levels predicted male parasite burdens, and if immune parameters could predict male testosterone levels. We found that male and female hosts had similar parasite burdens and female bats scored higher than males in only one immunological measure. Top models of helminth burden revealed interactions between body condition index and agglutination score as well as between agglutination score and host sex. Additionally, the strength of the relationships between sex, agglutination, and helminth burden is affected by body condition. Models of male parasite burden provided no support for testosterone predicting helminthiasis. Models that best predicted testosterone levels did not include parasite burden but instead consistently included month of capture and agglutination score. Thus, in our system, body condition was a more important predictor of immunity and worm burden than host sex. PMID:26898834

  5. Estimates of radioactive body burden in 131 Iodine therapy administrations in differentiated thyroid cancer

    International Nuclear Information System (INIS)

    Our earlier reported clearance pattern of RAI in differentiated thyroid cancer (DTC) had T½eff 16.45 h (stop hormone group) 12.35 h (rhTSH group) (t< 48 h) and T½eff>20 h (t>48 h) in both groups. We used exposure rates and calibrated scintillation probe counting to estimate radioactive body burden. Whole body retention factor is expressed from calculated patient's administered activity and further dose estimates. The retention factors calculated from mean exposure rates were 0.148±0.12 (n=211) at 48 h and 0.07±0.08 (n=68) at 72 h for thyroid hormone withdrawal group (THW) compared to 0.089±0.06 (n=24) at 48 h and 0.05±0.05 (n=19) at 72 h for rHTSH group. The estimated field of view (FOV) for a count rate variation within 8% was 65 cm. The calibration factor for the probe with water phantom (16 cm source depth) was 301 cpm/MBq respectively. 48 h retentions ranged from 0.071-0.096 with mean retention 0.081±0.013 in THW patients; and 0.008-0.089 with mean retention 0.039±0.03 in rhTSH patients. Estimated radioactive body burden at 48h were in the range 290-365 MBq, mean retention 323±37.7 MBq for THW and 44-308 MBq, mean retention 160±97 MBq for rHTSH group. Residence times in the two groups of patients were 21.97±3.8 h for THW patients and 14.28±2.75 h for rHTSH patients. Blood absorbed doses estimated were 0.128±0.031 mGy/MBq (n=8) for THW patients and 0.075±0.029 mGy/MBq (n=10) for rHTSH group. This resulted in the blood dose of 54.9±17.5 cGy (n=8 females) for THW; 29.6±8.6 cGy (n=4, males), 33.9±8.7 cGy (n=6, females). Probe counting method is able to provide the actual body burden of the patients, which help in understanding the whole body clearance patterns objectively, and to quantitate blood and bone marrow doses. (author)

  6. Studies on the current 137Cs body burden of children in Belarus - Can the dose be further reduced?

    International Nuclear Information System (INIS)

    After the Chernobyl reactor accident wide areas of Belarus were contaminated with radioactive fallout. The verification and documentation of the long-term development of radiation doses is still going on. A population group of special concern are the children living in contaminated regions. The annual dose limit of 1 mSv is still exceeded in some cases, essentially due to high body burdens of 137Cs as indicated by screening measurements with portable incorporation monitors. In this situation the evaluation of possible dose reduction measures in addition to the control of food contamination is being investigated. Special attention is given to the therapeutic application of a pectin preparation (Vitapect), for which a dose-lowering effect is presumed by Belarusian scientists. In a placebo-controlled double-blind study, several groups of contaminated children received a pectin compound named Vitapect for a two-week period during their stay in a sanatorium. For comparison the same number of control groups were given a placebo preparation. The 137Cs body burden of the children was measured at the beginning and the end. The mean relative reduction of the specific activity within the Vitapect groups was found to be ∼33%, whereas the specific activity of the children who received a placebo decreased only by ∼14%, due to clean food supply. It is known that pectins chemically bind cations like caesium in the gastrointestinal tract and thereby increase faecal excretion. Theoretical calculations based on this assumption and considering metabolism processes are qualitatively consistent with the experimentally found retention of radiocaesium in the human body after pectin treatment. (authors)

  7. Studies on the current Cs-137 body burden of children in Belarus - can the dose be further reduced?

    International Nuclear Information System (INIS)

    Full text: After the Chernobyl reactor accident wide areas of Belarus have been contaminated with radioactive fallout. The verification and documentation of the long-term development of radiation doses is still going on. A population group of special concern are the children living in contaminated regions. The annual dose limit of 1 mSv/a is still exceeded in some cases, essentially due to high body burdens of Cs-137 as indicated by screening measurements with portable incorporation monitors. In this situation the evaluation of possible dose reduction measures in addition to the control of food contamination is being investigated. Special attention is given to the cure-like application of a pectin-preparation (Vitapekt), for which a dose-lowering effect is presumed by Belarusian scientists. In a placebo-controlled double-blind study, several groups of contaminated children were treated with Vitapekt for a two-week period during their stay in a sanatorium. For comparison the same number of control groups were given a placebo preparation. The Cs-137 body burden of the children was measured at the beginning and the end. First results indicate a mean relative reduction of the specific activity within the Vitapekt groups of about 35 %, whereas the specific activity of the children who received a placebo decreased only by about 15 %. It is proposed that pectins chemically bind cesium in the gastrointestinal tract and thereby increase fecal excretion. Theoretical calculations based on this assumption are qualitatively consistent with the experimentally found retention of radiocesium in the human body after a pectin treatment. (author)

  8. The Body Burden of Caesium-137 in People of Southern Finland 1961-1963

    International Nuclear Information System (INIS)

    In connection with the investigations of the caesium-137, body burden of Finnish Lapps several measurements of smaller groups of people living in Southern Finland were carried out. In November 1961 eleven Helsinki inhabitants, five men and six women, 15 to 54 yr. old, were counted for caesium-137 and potassium in Stockholm. None of these persons were laboratory workers, two were schoolboys. They were apparently healthy. Their diet was studied by the interview method. Ten of these people were counted again in the mobile whole-body counter of the Radiochemical Department of the University of Helsinki one year later. The average body burden of caesium-137 in men (5, average age 29) had increased from 8.4 nc in November 1961 to 18.4 nc in November 1962, in women (5, average age 34) from 2.9 nc to 8.7 nc. Potassium contents were the same within 2% (men 140 g, women, 100 g) For more detailed studies larger control groups were selected at the beginning of 1963 and counted four times, in February, May, August and October. For the group of men 25 privates of an infantry battalion (age 19, average weight 65 kg), for women 24 girl students of a household school (age 22, average weight 60 kg), were selected. In both cases the diet could be checked in detail and could be considered to be an average Finnish diet. In addition, the individual food consumption of each subject was studied by interview with the aid of weighed samples. Caesium-137 contents of both diets were determined for the time periods between the measurements. In both groups the caesium-137 content remained about constant (men, 17,5 nc; women, 11 nc) until the end of June, when the caesium-137 content of milk and meat was approximately doubled within about one week. At the end of August the body burden of caesium-137 had increased in, both groups to about 40% above the spring level in the middle of October the men's values had increased by 22%, the women's values by 14% of the August level. The determination of

  9. Body burden of Hg in different bio-samples of mothers in Shenyang city, China.

    Directory of Open Access Journals (Sweden)

    Min-Ming Li

    Full Text Available Hg is an accumulative and neuro-toxic heavy metal which has a wide range of adverse effects in human health. However, few studies are available on body burden of Hg level in different bio-samples of pregnant women in Chinese population. Therefore, this study evaluated Hg levels in different maternal bio-samples in Shenyang city, China and investigated the correlation of Hg levels in different bio-samples. From October to December 2008, 200 pregnant women about to deliver their babies at ShengJing Hospital (Shenyang city, northeast of China participated in this study. The geometric mean (GM of Hg levels in cord blood, maternal venous blood, breast milk, and maternal urine were 2.18 µg/L, 1.17 µg/L, 1.14 µg/L, and 0.73 µg/L, respectively, and the GM of maternal hair Hg level was 404.45 µg/kg. There was a strong correlation between cord blood and maternal blood total Hg level (r = 0.713, P<0.001. Frequency of fish consumption more than or equal to 3 times per week during pregnancy was suggested as a significant risk factor of prenatal Hg exposure (unadjusted OR 3.5, adjusted OR 2.94, P<0.05. This study provides evidence about Hg burden of mothers and the risk factors of prenatal Hg exposure in Shenyang city, China.

  10. Determination of Plutonium Body Burdens from Measurements of Daily Urine Excretion

    International Nuclear Information System (INIS)

    The original data from 16 human experiments, as reported by Wright Langham and others, have been reanalysed using a simple compartment model. The functions obtained from this analysis, relating the body burden to the daily excretion in urine following an injection, are used in proposed mathematical models for the slow release of soluble plutonium into the blood stream from a wound site or the lungs. The results of calculations on the model for various hold-up times at the wound site or lungs are presented graphically. The presently available data on the biological variation between men and in the day-to-day plutonium in urine excretion in an individual are analysed and discussed with special reference to the best design of a routine urine sampling programme. (author)

  11. The absorbed dose in tooth enamel by 90SR body burden

    International Nuclear Information System (INIS)

    The residents of the villages along the Techa river, Southern Urals, Russia, were exposed mainly external by γ-rays from 137Cs and internal by γ-rays from 90Sr and its daughter 90Y, as a result of the heavy release of radioactive waste from the plutonium production facility Mayak into the Techa in 1950-51. The residents living at the lower part of the river were exposed only little externally but mainly internally due to their 90Sr body burden. Teeth from the latter group of residents which were extracted in 1994-95 in the course of dental care were collected and used for retrospective dosimetry more than 40 years after the main 90Sr ingestion. (author)

  12. The economic consequences of elevated body-lead burdens in urban children

    International Nuclear Information System (INIS)

    The following analysis develops the theory and implementation of the observed behavior technique in an altruistic setting, to assess the health benefits of reducing environmental lead exposure in urban children. Three models are presented which allow for endogenous body lead burden, risk of irreversible neurological damages, and Bayesian information. Conditions are derived under which the observed behavior technique can be modified to value the health consequences of exposure to a general class of persistent micropollutants (PMP's): the heavy metals. Benefit expressions reflect the tradeoff between parental wealth and child health when children are exposed to low level doses of lead. The purpose is to derive exact measures of marginal welfare change associated with variations in child body lead burden, and to determine the conditions under which these measures will be functions of observable parameters. The analysis presents an entirely ex ante approach to the recovery of benefit estimates when PMP exposure involves risk of irreversible health damages. In doing so, an empirical estimate is also obtained for the parental value of child health information that is used in the revision of prior risk beliefs. Risk of chronic irreversible health effects in younger generations from environmental lead exposure may be experienced by a large share of metropolitan population in the US. Given the large numbers of possible victims, the aggregate social value of avoiding this risk is an important policy issues. Moreover, the value of health risk information is potentially important to the use of an information program as a policy instrument in reducing health risk because it would enable the comparison of societal benefits from an information program to the cost of it's implementation

  13. An approach to calculating childhood body burdens of dibenzodioxins and dibenzofurans which accounts for age-dependent biological half lives

    Energy Technology Data Exchange (ETDEWEB)

    Paustenbach, D. [ChemRisk, San Francisco, CA (United States); Leung, H.W. [Leung, H.W. Private Consultant, Danbury, CT (United States); Scott, P. [ChemRisk, Pittsburgh, PA (United States); Kerger, B. [HSRI, Tallahassee, FL (United States)

    2004-09-15

    The purpose of this study is to apply an age-dependent half life model to examine the range of child (ages 0-7) body burdens that correspond to selected exposure scenarios involving background dietary and environmental doses of dioxins. The scenarios examined include breast-fed and nonbreast- fed infants feeding for 6 months, other dioxin uptake from foods through age 7, and exposures to urban residential soils at 1 ppb TCDD toxic equivalents (TEQ). These body burden estimates in children are then compared to the adult body burden estimates corresponding to the range of tolerable daily intakes (1 to 4 pg TEQ/kg-day) proposed by some U.S. and international regulatory/advisory groups.

  14. The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels

    International Nuclear Information System (INIS)

    This study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels. In children ages 38 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS. Toxic metal body burden was assessed by measuring urinary excretion of toxic metals, both before and after oral dimercaptosuccinic acid (DMSA). Multiple positive correlations were found between the severity of autism and the urinary excretion of toxic metals. Variations in the severity of autism measurements could be explained, in part, by regression analyses of urinary excretion of toxic metals before and after DMSA and the level of RBC glutathione (adjusted R2 of 0.220.45, P<.005 in all cases). This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals.

  15. The significance of hair mineral analysis as a means for assessing internal body burdens of environmental pollutants

    International Nuclear Information System (INIS)

    In recent years there has been a considerable growth of interest in problems of environmental pollution from industrial and agricultural substances and the harmful impact of such pollution on human health. There has been an increasing interest in using hair mineral analysis for biological monitoring of human population exposure to environmental mineral pollutants. This is because hair has some ideal attributes for such purposes. It can be collected by simple, non-invasive methods, and is easily sampled and stored. Concentrations of most of the toxic trace elements, i.e. mercury and lead, in scalp hair are at least an order of magnitude higher than those in body fluids or other easily accessible tissues. In addition, mineral elements in hair can easily be determined with good precision and sensitivity by nuclear as well as conventional methods of chemical analysis. Despite these apparent advantages of using hair as a biomonitor, serious uncertainty existed, and to some extent still exist, as to the meaningful interpretation of human hair mineral data in environmental health studies. The Co-ordinated Research Programme (CRP), which is the subject of this report, has attempted to tackle this problem by promoting a variety of studies (as distinct from routine monitoring) to investigate the quantitative relationships between internal body burdens of a number of elements of environmental health significance and their respective concentrations in hair. Refs, figs and tabs

  16. Dietary uptake efficiency of HCBP in channel catfish: The effect of fish contaminant body burden

    Energy Technology Data Exchange (ETDEWEB)

    Dabrowska, H.; Fisher, S.W.; Dabrowski, K.; Staubus, A.E. [Ohio State Univ., Columbus, OH (United States)

    1996-05-01

    Groups of juvenile channel catfish (Ictalurus punctatus) were exposed for 10 days to control or contaminated sediment, spiked with {sup 14}C-hexachlorobiphenyl (HCBP, 130 {micro}g{center_dot}kg{sup {minus}1} dry weight), in order to establish a known body burden. At the completion of that exposure, subsamples of fish were taken for HCBP analysis and the remaining fish were transferred to clean media. Each group transferred to clean media was then divided into two subgroups and offered either control or contaminated diet for 4 weeks. The contaminated diet (Tubifex worms) was spiked with {sup 14}C-HCBP (16.6 {micro}g{center_dot}kg{sup {minus}1} wet weight). Feeding rates of Tubifex were quantified as were fish growth rates and lipid levels. Fish (five specimens) were collected at the beginning of the dietary exposure and after 10, 20, and 30 days of exposure. Average individual growth rate constants were similar in all fish groups and ranged from 0.005 d{sup {minus}1} to 0.007 d{sup {minus}1}. Both fish groups fed contaminated Tubifex accumulated HCBP in an apparent linear fashion over the study period. The bioaccumulation factors (BAFs) were 1.38 and 1.66 for accumulation from sediment and uptake from food, respectively. The dietary uptake efficiency for HCBP was found not to be affected by contaminant present in the fish body.

  17. Cohort comparison study of cardiac disease and atherosclerotic burden in type 2 diabetic adults using whole body cardiovascular magnetic resonance imaging

    OpenAIRE

    Duce, Suzanne L.; Weir-McCall, Jonathan R.; Gandy, Stephen J.; Matthew, Shona Z.; Cassidy, Deirdre B.; McCormick, Lynne; Rauchhaus, Petra; Looker, Helen; Helen M Colhoun; Houston, J. Graeme

    2015-01-01

    BACKGROUND: Whole body cardiovascular MR (WB CVMR) combines whole body angiography and cardiac MR assessment. It is accepted that there is a high disease burden in patients with diabetes, however the quantification of the whole body atheroma burden in both arterial and cardiac disease has not been previously reported. In this study we compare the quantified atheroma burden in those individuals with and without diabetes by clinical cardiovascular disease (CVD) status.METHODS: 158 participants ...

  18. Cohort comparison study of cardiac disease and atherosclerotic burden in type 2 diabetic adults using whole body cardiovascular magnetic resonance imaging

    OpenAIRE

    Duce, Suzanne L.; Weir-McCall, Jonathan R.; Gandy, Stephen J.; Matthew, Shona Z.; Cassidy, Deirdre B.; McCormick, Lynne; Rauchhaus, Petra; Looker, Helen; Helen M Colhoun; Houston, J. Graeme

    2015-01-01

    Background Whole body cardiovascular MR (WB CVMR) combines whole body angiography and cardiac MR assessment. It is accepted that there is a high disease burden in patients with diabetes, however the quantification of the whole body atheroma burden in both arterial and cardiac disease has not been previously reported. In this study we compare the quantified atheroma burden in those individuals with and without diabetes by clinical cardiovascular disease (CVD) status. Methods 158 participants u...

  19. Body burden of cadmium and its related factors: A large-scale survey in China

    International Nuclear Information System (INIS)

    A survey of more than 6000 participants from four distinct non-polluted and polluted regions in China was conducted to evaluate the body burden of cadmium (Cd) on the Chinese populations using urinary Cd (UCd) as a biomarker. The findings revealed that the UCd level was 1.24 μg/g creatinine (μg/g cr) for the sample population from non-polluted Shanghai, and the UCd levels exceeded 5 μg/g cr, which is the health-based exposure limit set by the World Health Organization (WHO), in 1.1% of people. The mean UCd levels in moderately polluted (Hubei and Liaoning) and highly polluted areas (Guizhou) were 4.69 μg/g cr, 3.62 μg/g cr and 6.08 μg/g cr, respectively, and these levels were 2.9 to 4.9 times the levels observed in Shanghai. Notably, the UCd levels exceeded the recently updated human biomonitoring II values (i.e., intervention or “action level”) in 44.8%–87.9% of people from these areas compared to only 5.1%–21.4% of people in Shanghai. The corresponding prevalence of elevated UCd levels (> WHO threshold, 5 μg/g cr) was also significantly higher (30.7% to 63.8% vs. 1.1%), which indicates that elevated Cd-induced health risks to residents in these areas. Age and region were significant determinants for UCd levels in a population, whereas gender did not significantly influence UCd. - Highlights: • We performed a Cd exposure survey that involved more than 6000 Chinese subjects. • The body burden of Cd in most of subjects of non-polluted Shanghai is relatively safe. • The UCd levels were much higher in the subjects from polluted areas than from Shanghai. • The UCd levels in the population from Guizhou substantially exceeded the safety limit. • Age and region were significant determinants of UCd

  20. Body burden of cadmium and its related factors: A large-scale survey in China

    Energy Technology Data Exchange (ETDEWEB)

    Ke, Shen; Cheng, Xi-Yu; Li, Hao; Jia, Wen-Jing; Zhang, Jie-Ying; Luo, Hui-Fang; Wang, Zi-Ling; Chen, Zhi-Nan, E-mail: chen_zhinan56@163.com

    2015-04-01

    A survey of more than 6000 participants from four distinct non-polluted and polluted regions in China was conducted to evaluate the body burden of cadmium (Cd) on the Chinese populations using urinary Cd (UCd) as a biomarker. The findings revealed that the UCd level was 1.24 μg/g creatinine (μg/g cr) for the sample population from non-polluted Shanghai, and the UCd levels exceeded 5 μg/g cr, which is the health-based exposure limit set by the World Health Organization (WHO), in 1.1% of people. The mean UCd levels in moderately polluted (Hubei and Liaoning) and highly polluted areas (Guizhou) were 4.69 μg/g cr, 3.62 μg/g cr and 6.08 μg/g cr, respectively, and these levels were 2.9 to 4.9 times the levels observed in Shanghai. Notably, the UCd levels exceeded the recently updated human biomonitoring II values (i.e., intervention or “action level”) in 44.8%–87.9% of people from these areas compared to only 5.1%–21.4% of people in Shanghai. The corresponding prevalence of elevated UCd levels (> WHO threshold, 5 μg/g cr) was also significantly higher (30.7% to 63.8% vs. 1.1%), which indicates that elevated Cd-induced health risks to residents in these areas. Age and region were significant determinants for UCd levels in a population, whereas gender did not significantly influence UCd. - Highlights: • We performed a Cd exposure survey that involved more than 6000 Chinese subjects. • The body burden of Cd in most of subjects of non-polluted Shanghai is relatively safe. • The UCd levels were much higher in the subjects from polluted areas than from Shanghai. • The UCd levels in the population from Guizhou substantially exceeded the safety limit. • Age and region were significant determinants of UCd.

  1. Relationship of Parasites and Pathologies to Contaminant Body Burden in Sentinel Bivalves: NOAA Status and Trends `Mussel Watch? Program

    OpenAIRE

    Kim, Yungkul; Powell, Eric N.; Wade, Terry L.; Presley, Bobby J.

    2008-01-01

    Relationship of Parasites and Pathologies to Contaminant Body Burden in Sentinel Bivalves: NOAA Status and Trends `Mussel Watch? Program correspondence: Corresponding author. (Kim, Yungkul) (Kim, Yungkul) Haskin Shellfish Research Laboratory Rutgers University 6959 Miller Ave Port Norris NJ 08349-3167 - (Kim, Yungkul) UNITED STATES (Kim, Yungkul) Haskin Shellfish Research Laboratory Rutgers University 6959 Miller ...

  2. Chemical evolution of primitive solar system bodies

    Science.gov (United States)

    Oro, J.; Mills, T.

    1989-01-01

    Observations on organic molecules and compounds containing biogenic elements in the interstellar medium and in the primitive bodies of the solar system are reviewed. The discovery of phosphorus molecular species in dense interstellar clouds, the existence of organic ions in the dust and gas phase of the comas of Comet Halley, and the presence of presolar, deuterium-hydrogen ratios in the amino acids of carbonaceous chondrites are discussed. The relationships between comets, dark asteroids, and carbonaceous chondrites are examined. Also, consideration is given to the chemical evolution of Titan, the primitive earth, and early Mars.

  3. Temperature- and parasite-induced changes in toxicity and lethal body burdens of pentachlorophenol in the freshwater clam Pisidium amnicum.

    Science.gov (United States)

    Heinonen, J; Kukkonen, J V; Holopainen, I J

    2001-12-01

    Seasonal variation in abiotic and biotic environments may modify the toxicity of organic chemicals for aquatic organisms. In present study, survival of the freshwater clam Pisidium amnicum was studied in laboratory exposures to pentachlorophenol (PCP) in April (at 5 degress C) and July (at 19 degress C). Behavioral responses, mean survival times (MSTs), and the lethal body burdens (LBBs) of PCP for uninfected clams and for clams infected by digenean trematodes were determined separately in two PCP concentrations, 100 and 300 microgram/L. Analysis of data revealed reduced behavioral activity of the clams in the PCP exposure compared to that in the control. The time needed for toxic responses was greatly affected by temperature; MSTs were 5 to 15 times longer in winter than at summer temperatures. Unexpectedly, the infected clams in summer were more tolerant to PCP than the uninfected clams. Despite the differences in survival times, the LBBs between the seasons were constant. However, in summer, the infected clams had significantly higher LBBs than the uninfected clams. The differences in survival and LBBs between the infected and uninfected clams are suggested to be caused by the high lipid contents found in parasites, which may change the internal distribution of PCP. PMID:11764161

  4. The use of comparative 137Cs body burden estimates from environmental data/models and whole body counting to evaluate diet models for the ingestion pathway.

    Science.gov (United States)

    Robison, W L; Sun, C

    1997-07-01

    Rongelap and Utirik Atolls were contaminated on 1 March 1954, by a U.S. nuclear test at Bikini Atoll code named BRAVO. The people at both atolls were removed from their atolls in the first few days after the detonation and were returned to their atolls at different times. Detailed studies have been carried out over the years by Lawrence Livermore National Laboratory (LLNL) to determine the radiological conditions at the atolls and estimate the doses to the populations. The contribution of each exposure pathway and radionuclide have been evaluated. All dose assessments show that the major potential contribution to the estimated dose is 137Cs uptake via the terrestrial food chain. Brookhaven National Laboratory (BNL) has carried out an extensive whole body counting program at both atolls over several years to directly measure the 137Cs body burden. Here we compare the estimates of the body burdens from the LLNL environmental method with body burdens measured by the BNL whole body counting method. The combination of the results from both methods is used to evaluate proposed diet models to establish more realistic dose assessments. Very good agreement is achieved between the two methods with a diet model that includes both local and imported foods. Other diet models greatly overestimate the body burdens (i.e., dose) observed by whole body counting. The upper 95% confidence limit of interindividual variability around the population mean value based on the environmental method is similar to that calculated from direct measurement by whole body counting. Moreover, the uncertainty in the population mean value based on the environmental method is in very good agreement with the whole body counting data. This provides additional confidence in extrapolating the estimated doses calculated by the environmental method to other islands and atolls. PMID:9199225

  5. The use of comparative 137Cs body burden estimates from environmental data/models and whole body counting to evaluate diet models for the ingestion pathway

    International Nuclear Information System (INIS)

    Rongelap and Utirik Atolls were contaminated on 1 March 1954, by a U.S. nuclear test at Bikini Atoll code named BRAVO. The people at both atolls were removed from their atolls in the first few days after the detonation and were returned to their atolls at different times. Detailed studies have been carried out over the years by Lawrence Livermore National Laboratory (LLNL) to determine the radiological conditions at the atolls and estimate the doses to the populations. The contribution of each exposure pathway and radionuclide have been evaluated. All dose assessments show that the major potential contribution to the estimated dose is 137Cs uptake via the terrestrial food chain. Brookhaven National Laboratory (BNL) has carried out an extensive whole body counting program at both atolls over several years to directly measure the 137Cs body burden. Here we compare the estimates of the body burdens from the LLNL environmental method with body burdens measured by the BNL whole body counting method. The combination of the results from both methods is used to evaluate proposed diet models to establish more realistic dose assessments. Very good agreement is achieved between the two methods with a diet model that includes both local and imported foods. Other diet models greatly overestimate the body burdens (i.e., dose) observed by whole body counting. The upper 95% confidence limit of interindividual variability around the population mean value based on the environmental method is similar to that calculated from direct measurement by whole body counting. Moreover, the uncertainty in the population mean value based on the environmental method is in very good agreement with the whole body counting data. This provides additional confidence in extrapolating the estimated doses calculated by the environmental method to other islands and atolls. 46 refs., 8 figs., 5 tabs

  6. Body burden of pesticides and wastewater-derived pollutants on freshwater invertebrates: Method development and application in the Danube River.

    Science.gov (United States)

    Inostroza, Pedro A; Wicht, Anna-Jorina; Huber, Thomas; Nagy, Claudia; Brack, Werner; Krauss, Martin

    2016-07-01

    While environmental risk assessment is typically based on toxicant concentrations in water and/or sediment, awareness is increasing that internal concentrations or body burdens are the key to understand adverse effects in organisms. In order to link environmental micropollutants as causes of observed effects, there is an increasing demand for methods to analyse these chemicals in organisms. Here, a multi-target screening method based on pulverised liquid extraction (PuLE) and a modified QuEChERS approach with an additional hexane phase was developed. It is capable to extract and quantify organic micropollutants of diverse chemical classes in freshwater invertebrates. The method was tested on gammarids from the Danube River (within the Joint Danube Survey 3) and target compounds were analysed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Furthermore, a non-target screening using high resolution-tandem mass spectrometry (LC-HRMS/MS) was conducted. A total of 17 pollutants were detected and/or quantified in gammarids at low concentrations. Pesticide concentrations ranged from 0.1 to 6.52 ng g(-1) (wet weight), those of wastewater-derived pollutants from 0.1 to 2.83 ng g(-1) (wet weight). The presence of wastewater-derived pollutants was prominent at all spots sampled. Using non-target screening, we could successfully identify several chlorinated compounds. These results demonstrate for the first time the presence of pesticides and wastewater-derived pollutants in invertebrates of the Danube River. PMID:27064613

  7. Bioassay of hair for estimation of body burden by tritium exposure

    International Nuclear Information System (INIS)

    For accurate estimation of radiation dose to human body from tritium exposure, it is needed to assess the concentration of tritium organically bound to the tissue constituents(OBT) as well as body water tritium. Since hair is an easily accessible tissue, it seems to be interesting to study the possibility of using hair for this purpose. In the present study, the pattern of tritium incorporation into hair and the quantitative relationship between OBT content in hair and in other internal tissues were investigated in rats exposed singly or continously to tritiated water, tritiated leucine and tritiated glycine. The rate of tritium incorporation into hair was slower than that into other tissues and the maximum concentrations were found on the 15-30th day after a single ingestion. The alterations in the concentration of OBT in internal tissues due to the difference of chemical form of ingested tritium were reflected on the OBT concentration in hair. Especially, the OBT content in hair under the condition of continuous exposure was almost the same as that in other tissues. These findings indicate the validity of hair analysis as a means for assessing OBT deposition in the body or tissues. (author)

  8. Whole body cardiovascular magnetic resonance imaging to stratify symptomatic and asymptomatic atherosclerotic burden in patients with isolated cardiovascular disease

    OpenAIRE

    Weir-McCall, Jonathan R.; Duce, Suzanne L.; Gandy, Stephen J.; Matthew, Shona Z.; Martin, Patricia; Cassidy, Deirdre B.; McCormick, Lynne; Belch, Jill J. F.; Struthers, Allan D.; Helen M Colhoun; Houston, J. Graeme

    2016-01-01

    Background: The aim of this study was to use whole body cardiovascular magnetic resonance imaging (WB CVMR) to assess the heart and arterial network in a single examination, so as to describe the burden of atherosclerosis and subclinical disease in participants with symptomatic single site vascular disease. Methods: 64 patients with a history of symptomatic single site vascular disease (38 coronary artery disease (CAD), 9 cerebrovascular disease, 17 peripheral arterial disease (PAD)) underwen...

  9. Whole body cardiovascular magnetic resonance imaging to stratify symptomatic and asymptomatic atherosclerotic burden in patients with isolated cardiovascular disease

    OpenAIRE

    Weir-McCall, Jonathan R.; Duce, Suzanne L.; Gandy, Stephen J.; Matthew, Shona Z.; Martin, Patricia; Cassidy, Deirdre B.; McCormick, Lynne; Belch, Jill J. F.; Struthers, Allan D.; Helen M Colhoun; Houston, J. Graeme

    2016-01-01

    Background The aim of this study was to use whole body cardiovascular magnetic resonance imaging (WB CVMR) to assess the heart and arterial network in a single examination, so as to describe the burden of atherosclerosis and subclinical disease in participants with symptomatic single site vascular disease. Methods 64 patients with a history of symptomatic single site vascular disease (38 coronary artery disease (CAD), 9 cerebrovascular disease, 17 peripheral arterial disease (PAD)) underwent ...

  10. Follow-up of atheroma burden with sequential whole body contrast enhanced MR angiography: a feasibility study

    OpenAIRE

    Weir-McCall, Jonathan R.; White, Richard D; Ramkumar, Prasad G.; Gandy, Stephen J.; Khan, Faisel; Belch, Jill J. F.; Struthers, Allan D.; Houston, J. Graeme

    2016-01-01

    Assess the feasibility of whole body magnetic resonance angiography (WB-MRA) for monitoring global atheroma burden in a population with peripheral arterial disease (PAD). 50 consecutive patients with symptomatic PAD referred for clinically indicated MRA were recruited. Whole body MRA (WB-MRA) was performed at baseline, 6 months and 3 years. The vasculature was split into 31 anatomical arterial segments. Each segment was scored according to degree of luminal narrowing: 0 = normal, 1 = 

  11. Body burdens of brominated flame retardants and other persistent organo-halogenated compounds and their descriptors in US girls

    International Nuclear Information System (INIS)

    Background: Levels of brominated flame retardants are increasing in US populations, yet little data are available on body burdens of these and other persistent hormonally active agents (HAAs) in school-aged children. Exposures to such chemicals may affect a number of health outcomes related to development and reproductive function. Objective: Determine the distribution of biomarkers of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and organo-chlorinated pesticides (OCPs), such as DDT/DDE, in children, and their variation by key descriptor variables. Methods: Ethnically diverse cohorts of girls 6-8 y old at baseline are being followed for growth and pubertal development in a multi-site, longitudinal study. Nearly 600 serum samples from the California and Ohio sites were analyzed for lipids, 35 PCB congeners, 11 PBDE congeners, and 9 OCPs. The biomarker distributions were examined and geometric means compared for selected analytes across categories of age, race, site, body mass index (BMI), parental education, maternal age at delivery, and breast feeding in adjusted models. Results: Six PBDE congeners were detected among greater than 70% of samples, with BDE-47 having the highest concentration (median 42.2, range 4.9-855 ng/g lipid). Girls in California had adjusted geometric mean (GM) PBDE levels significantly higher than girls in Ohio. Furthermore, Blacks had significantly higher adjusted GMs of all six PBDE congeners than Whites, and Hispanics had intermediate values. GMs tended to be lower among more obese girls, while other variables were not strongly associated. In contrast, GMs of the six PCB congeners most frequently detected were significantly lower among Blacks and Hispanics than Whites. PCBs and the three pesticides most frequently detected were also consistently lower among girls with high BMI, who were not breast-fed, whose mothers were younger, or whose care-givers (usually parents) were less educated. Girls in California had

  12. Body burdens of brominated flame retardants and other persistent organo-halogenated compounds and their descriptors in US girls

    Energy Technology Data Exchange (ETDEWEB)

    Windham, Gayle C., E-mail: gayle.windham@cdph.ca.gov [CA Department of Public Health, DEODC, 850 Marina Bay Pkwy, Bldg. P, Richmond, CA 94804 (United States); Pinney, Susan M. [University of Cincinnati College of Medicine, Cincinnati, OH 45267 (United States); Sjodin, Andreas [Centers for Disease Control and Prevention, Atlanta, GA 30341 (United States); Lum, Raymond [Impact Assessment Inc., San Diego, CA (United States); Jones, Richard S.; Needham, Larry L. [Centers for Disease Control and Prevention, Atlanta, GA 30341 (United States); Biro, Frank M. [University of Cincinnati College of Medicine, Cincinnati, OH 45267 (United States); Hiatt, Robert A. [University of California Medical School, San Francisco, CA (United States); Kushi, Lawrence H. [Kaiser Permanente Northern California, Oakland, CA 94612 (United States)

    2010-04-15

    Background: Levels of brominated flame retardants are increasing in US populations, yet little data are available on body burdens of these and other persistent hormonally active agents (HAAs) in school-aged children. Exposures to such chemicals may affect a number of health outcomes related to development and reproductive function. Objective: Determine the distribution of biomarkers of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and organo-chlorinated pesticides (OCPs), such as DDT/DDE, in children, and their variation by key descriptor variables. Methods: Ethnically diverse cohorts of girls 6-8 y old at baseline are being followed for growth and pubertal development in a multi-site, longitudinal study. Nearly 600 serum samples from the California and Ohio sites were analyzed for lipids, 35 PCB congeners, 11 PBDE congeners, and 9 OCPs. The biomarker distributions were examined and geometric means compared for selected analytes across categories of age, race, site, body mass index (BMI), parental education, maternal age at delivery, and breast feeding in adjusted models. Results: Six PBDE congeners were detected among greater than 70% of samples, with BDE-47 having the highest concentration (median 42.2, range 4.9-855 ng/g lipid). Girls in California had adjusted geometric mean (GM) PBDE levels significantly higher than girls in Ohio. Furthermore, Blacks had significantly higher adjusted GMs of all six PBDE congeners than Whites, and Hispanics had intermediate values. GMs tended to be lower among more obese girls, while other variables were not strongly associated. In contrast, GMs of the six PCB congeners most frequently detected were significantly lower among Blacks and Hispanics than Whites. PCBs and the three pesticides most frequently detected were also consistently lower among girls with high BMI, who were not breast-fed, whose mothers were younger, or whose care-givers (usually parents) were less educated. Girls in California had

  13. Relationship between whole-body tumor burden, clinical phenotype, and quality of life in patients with neurofibromatosis.

    Science.gov (United States)

    Merker, Vanessa L; Bredella, Miriam A; Cai, Wenli; Kassarjian, Ara; Harris, Gordon J; Muzikansky, Alona; Nguyen, Rosa; Mautner, Victor F; Plotkin, Scott R

    2014-06-01

    Patients with neurofibromatosis 1 (NF1), NF2, and schwannomatosis share a predisposition to develop multiple nerve sheath tumors. Previous studies have demonstrated that patients with NF1 and NF2 have reduced quality of life (QOL), but no studies have examined the relationship between whole-body tumor burden and QOL in these patients. We administered a QOL questionnaire (the SF-36) and a visual analog pain scale (VAS) to a previously described cohort of adult neurofibromatosis patients undergoing whole-body MRI. One-sample t-tests were used to compare norm-based SF-36 scores to weighted population means. Spearman correlation coefficients and multiple linear regression analyses controlling for demographic and disease-specific clinical variable were used to relate whole-body tumor volume to QOL scales. Two hundred forty-five patients (142 NF1, 53 NF2, 50 schwannomatosis) completed the study. Subjects showed deficits in selected subscales of the SF-36 compared to adjusted general population means. In bivariate analysis, increased tumor volume was significantly associated with pain in schwannomatosis patients, as measured by the SF-36 bodily pain subscale (rho = -0.287, P = 0.04) and VAS (rho = 0.34, P = 0.02). Regression models for NF2 patients showed a positive relationship between tumor burden and increased pain, as measured by the SF-36 (P = 0.008). Patients with NF1, NF2, and schwannomatosis suffer from reduced QOL, although only pain shows a clear relationship to patient's overall tumor burden. These findings suggest that internal tumor volume is not a primary contributor to QOL and emphasize the need for comprehensive treatment approaches that go beyond tumor-focused therapies such as surgery by including psychosocial interventions. PMID:24664633

  14. Potassium body burdens in occupational users of egyptian nuclear research center

    International Nuclear Information System (INIS)

    A simple calibration procedure for inshas whole body counter for evaluating total potassium have been adopted. More than 120 egyptian employee in the nuclear research center (N. R. C.) were studied for their total body potassium (TBK). The potassium values were found to have an average of 2.85 gm k kg-1 body weight for males and 2.62 gm k kg-1 for females, which is higher than the recommended value given for reference man by ICRP. The TBK varied directly with body build index and is slightly dependent.7 figs., 1 tab

  15. [Secondhand smoke in hospitality venues. Exposure, body burden, economic and health aspects in conjunction with smoking bans].

    Science.gov (United States)

    Fromme, H; Kuhn, J; Bolte, G

    2009-04-01

    Secondhand smoke was classified by national and international organisations as a known cause of cancer in humans and has many adverse health effects, especially cardiovascular diseases and lung tumours. Global studies have clearly shown that hospitality venues have the highest levels of indoor air pollution containing different substances that are clearly carcinogenic--such as tobacco-related chemicals--compared with other, smoke-free indoor spaces. Data from the human biomonitoring of non-smoking employees in the food service industry confirm this high exposure level. Non-smokers exposed to secondhand smoke in these environments are at increased risk for adverse health effects. The consistent protection of non-smokers in public places such as restaurants and bars through a smoking ban results in a significant reduction of the pollutants in the air (mostly > 90%) and clearly reduces the internal body burden for users and employees. Furthermore, health complaints by non-smoking employees are reduced and the higher risk for lung tumours of employees in the food service industry compared with the general population can be effectively reduced as well. According to current standards of knowledge, other measures such as spatial separation of smoking areas or the use of mechanical venting systems do not achieve a comparably high and effective pollutant reduction under field conditions. Studies concerning the economic effects of prohibiting smoking in public places conducted in various countries have shown that beverage-focused gastronomic enterprises experience a short-term down trend but that food-focused gastronomic enterprises do not experience any negative or even positive effects. The positive effects of a ban on smoking in public places on the general population are a decline in cigarette consumption and the reduction of secondhand smoke exposure by non-smokers. Smoking bans in hospitality venues are not necessarily linked with a shift of the tobacco consumption to

  16. Power generation from chemically cleaned coals: do environmental benefits of firing cleaner coal outweigh environmental burden of cleaning?

    DEFF Research Database (Denmark)

    Ryberg, Morten W.; Owsianiak, Mikolaj; Laurent, Alexis;

    2015-01-01

    beneficiation of coals using acid and alkali–acid leaching procedures is evaluated as a potential coal cleaning technology employing life cycle assessment (LCA). Taking into account the environmental benefits from firing cleaner coal in pulverized coal power plants and the environmental burden of the cleaning......Power generation from high-ash coals is a niche technology for power generation, but coal cleaning is deemed necessary to avoid problems associated with low combustion efficiencies and to minimize environmental burdens associated with emissions of pollutants originating from ash. Here, chemical...... on the impact category. The largest potential of the technology is observed for high-ash lignites, with initial ash content above 30%, for which the environmental benefits from firing cleaner coal can outweigh the environmental burden of cleaning for some impact categories. Overall, we recommend to policy...

  17. Assessment of Radioactivity in Man. Vol. I. Proceedings of the Symposium on the Assessment of Radioactive Body Burdens in Man

    International Nuclear Information System (INIS)

    This Symposium on the Assessment of Radioactive Body Burdens in Man was organized jointly by the International Atomic Energy Agency, the International Labour Organisation and the World Health Organization and was held in Heidelberg from 11-15 May 1964. It was attended by 181 participants from 28 countries and 6 international organizations. It was the objective of the Symposium to bring together experts from the various scientific disciplines of physics, chemistry, biology, medicine and mathematics, and to survey their experience in the assessment of radioactive body burdens in man and the resultant radiation doses. In most investigations of internal contamination the errors in the physical measurements are smaller than the errors associated with the interpretation of measurements. For this reason special emphasis was laid in this meeting on the interpretation of measured data. The 67 papers and the discussions which they stimulated are published in these Proceedings produced in two volumes. Volume I includes all papers which deal with problems generally common to many isotopes: in- vivo counting, bioassay techniques, sample counting and analysis of data. Volume II includes those papers concerned with radioisotopes of specific elements: caesium, radium, radon, strontium, tritium, thorium, uranium, plutonium and rare earth elements. These Proceedings should prove invaluable to all radiation protection services entrusted with the physical surveillance of internal radiation exposure of man. They should complement the studies of the International Commission on Radiological Protection (ICRP) and assist the work of the Organizations that jointly organized the meeting

  18. Assessment of Radioactivity in Man. Vol. II. Proceedings of the Symposium on the Assessment of Radioactive Body Burdens

    International Nuclear Information System (INIS)

    This Symposium on the Assessment of Radioactive Body Burdens in Man was organized jointly by the International Atomic Energy Agency, the International Labour Organisation and the World Health Organization and was held in Heidelberg from 11-15 May 1964. It was attended by 181 participants from 28 countries and 6 international organizations. It was the objective of the Symposium to bring together experts from the various scientific disciplines of physics, chemistry, biology, medicine and mathematics, and to survey their experience in the assessment of radioactive body burdens in man and the resultant radiation doses. In most investigations of internal contamination the errors in the physical measurements are smaller than the errors associated with the interpretation of measurements. For this reason special emphasis was laid in this meeting on the interpretation of measured data. The 67 papers and the discussions which they stimulated are published in these Proceedings produced in two volumes. Volume I includes all papers which deal with problems generally common to many isotopes: in- vivo counting, bioassay techniques, sample counting and analysis of data. Volume II includes those papers concerned with radioisotopes of specific elements: caesium, radium, radon, strontium, tritium, thorium, uranium, plutonium and rare earth elements. These Proceedings should prove invaluable to all radiation protection services entrusted with the physical surveillance of internal radiation exposure of man. They should complement the studies of the International Commission on Radiological Protection (ICRP) and assist the work of the Organizations that jointly organized the meeting

  19. Body burden of fallout 137Cs in the inhabitants of Moscow in 1980-1983

    International Nuclear Information System (INIS)

    Several groups of people living in Moscow were measured for fallout 137Cs in 1980-1983. In vivo measurements of incorporated 137Cs were made with use of a whole-body counter. The minimum measurable activities of 137Cs were 37 and 17 Bq consequently for time of measurement 15 and 30 min. All persons measured were classified into four groups, personnel of whole-body counters laboratory, teenagers-sportsman, patients of a Moscow hospital (with heart and kidneys diseases) and normal adults-inhabitants of Moscow. The activity of 137Cs in the normal adults and patients was observed to decrease during the period of investigation. It was shown that by the end of 1983 the great majority of the results were similar and below the minimum measurable activity (for time of measurement 15 min)

  20. The significance of hair mineral analysis as a means for assessing internal body burdens of environmental pollutants

    International Nuclear Information System (INIS)

    During a five-year period, the International Atomic Energy Agency supported a Coordinated Research Programme (CRP) to investigate the quantitative relationship between internal body burdens of a number of elements of environmental health significance and their respective concentrations in hair. The use of nuclear-related analytical techniques, such as neutron activation analysis, X-ray fluorescence, particle-induced X-ray emission and radiotracers, was emphasized. One aspect of the CRP focused on studies in man, using autopsy cases, of mineral distribution in five tissues, i.e. liver, kidney, lung, brain and bone in addition to hair, and the elements of primary importance were As, Cd, Cu, Hg, Pb, Se and Zn. Emphasis was placed on analytical quality assurance. Hair and internal tissue samples were obtained from subjects from Bulgaria, China, the former German Democratic Republic, Hungary, Japan, Norway and Sweden. (author) 4 refs.; 4 figs.; 3 tabs

  1. Follow-up of atheroma burden with sequential whole body contrast enhanced MR angiography: a feasibility study.

    Science.gov (United States)

    Weir-McCall, Jonathan R; White, Richard D; Ramkumar, Prasad G; Gandy, Stephen J; Khan, Faisel; Belch, Jill J F; Struthers, Allan D; Houston, J Graeme

    2016-05-01

    Assess the feasibility of whole body magnetic resonance angiography (WB-MRA) for monitoring global atheroma burden in a population with peripheral arterial disease (PAD). 50 consecutive patients with symptomatic PAD referred for clinically indicated MRA were recruited. Whole body MRA (WB-MRA) was performed at baseline, 6 months and 3 years. The vasculature was split into 31 anatomical arterial segments. Each segment was scored according to degree of luminal narrowing: 0 = normal, 1 = <50 %, 2 = 50-70 %, 3 = 71-99 %, 4 = vessel occlusion. The score from all assessable segments was summed, and then normalised to the number of assessable vessels. This normalised score was divided by four (the maximum vessel score) and multiplied by 100 to give a final standardised atheroma score (SAS) with a score of 0-100. Progression was assessed with repeat measure ANOVA. 36 patients were scanned at 0 and 6 months, with 26 patients scanned at the 3 years follow up. Only those who completed all three visits were included in the final analysis. Baseline atherosclerotic burden was high with a mean SAS of 15.7 ± 10.3. No significant progression was present at 6 months (mean SAS 16.4 ± 10.5, p = 0.67), however there was significant disease progression at 3 years (mean SAS 17.7 ± 11.5, p = 0.01). Those with atheroma progression at follow-up were less likely to be on statin therapy (79 vs 100 %, p = 0.04), and had significantly higher baseline SAS (17.6 ± 11.2 vs 10.7 ± 5.1, p = 0.043). Follow up of atheroma burden is possible with WB-MRA, which can successfully quantify and monitor atherosclerosis progression at 3 years follow-up. PMID:26809611

  2. Hair as an indicator of the body burden of metals in relation to age

    International Nuclear Information System (INIS)

    Many factors influencing metal deposition in hair are still unknown. Animal experiments were performed to obtain data on the mechanism of transfer of elements into hair and to estimate whether hair retention is influenced by age, sex and chelating agent treatment. Experiments were performed on albino rats (Wistar strain) of different age and sex. Whole body hair (skin included) and organ retention of various elements was determined at different periods of time after intraperitoneal administration of the radioactive isotopes 115mCd, 203Hg, 54Mn, 59Fe, 65Zn, 141Ce, 137Cs, 203Pb and 85Sr. In some experiments DTPA was used for reducing body retention of 155mCd and 141Ce and DMPS for reducing 203Hg retention. Results show that hair and organ retention of elements in rats varies with age, sex and chelation treatment and such changes are specific for each element and can not be generalized. Age as a factor influencing hair retention of metals is likely to be more important for some elements than for others. In kinetic studies we found that due to differences in element distribution and kinetics, the relationship between hair and organ retention at various time intervals varies both with age and the element concerned. Sex influences not only hair but also metal retention and distribution in other organs. (author). 4 refs

  3. Organohalogen body burdens in a breast cancer case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Petreas, M.; She, J.; Visita, P.; Winkler, J. [Hazardous Materials Lab., California Dept. of Toxic Substances Control, Berkeley, CA (United States); Hurley, S.; Smith, D.; Reynolds, P. [Environmental Health Investigations Branch, California Dept. of Health Services, Oakland, CA (United States); Jeffrey, S.; Mahoney, E. [Dept. of Surgery, Stanford Univ. School of Medicine, Stanford, CA (United States)

    2004-09-15

    Due to their lipophilic properties, dioxins (PCDD/PCDFs) and other organohalogen compounds bioaccumulate in the food chain, with diet accounting for over 90% of non-occupational exposures. To date, few epidemiologic studies have examined the relationship between dioxins and breast cancer in human populations. Most have examined risks in occupational cohorts or in populations exposed to dioxins from the Seveso accident6-8. Results from these studies have been conflicting and have largely been limited by a lack of individual-level measures of exposure, small numbers of cases, and inability to account for established breast cancer risk factors. Very little is known about the potential health effects of low-level environmental dioxin contamination. We present data on PCDD/PCDFs, organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs) in adipose tissues of women participating in a breast cancer case-control study centered in the San Francisco Bay Area. In addition, we examine distributions of these chemicals in breast and abdominal adipose of women undergoing mastectomies with concurrent breast reconstruction. If concentrations were equivalent, use of abdominal adipose would greatly enhance the pool for controls for future epidemiological studies.

  4. An effective and better strategy for reducing body burden of radiostrontium

    International Nuclear Information System (INIS)

    In this study we have examined the effect of different calcium salts, Ca gluconate (CaG), Ca lactate (CaL), Ca carbonate (CaC) and Ca phosphate (CaP), on the clearance of radiostrontium (*Sr) administered either intraperitoneally (ip) (*Sr-ip group) or orally (*Sr-oral group) in rats. The influence of these Ca salts was examined in a group of animals administered *Sr ip, while the effect of three Ca salts (CaG, CaL and CaP) was studied in another group of rats given *Sr orally and compared with that of Ca alginate (CaA), normally advised for *Sr decorporation. Rats from both groups were subdivided into control and four experimental subgroups and were housed individually. The experimental subgroups were given the respective Ca salts (elemental Ca = 9 mg/rat/day) 2 h post 85Sr, and thereafter once daily. In the *Sr-ip group, CaG was administered ip while the other Ca salts were given orally. In the *Sr-oral group all Ca salts were administered orally. In addition, the diet of all the experimental subgroups was supplemented with the respective Ca salts to 2% elemental Ca. The whole-body retention (WBR) of *Sr in animals treated with Ca salts was found to be significantly reduced from 50-60% at 24 h to 20-30% at the end of 15 days compared with 70-80% at 24 h to 50-60% at the end of 15 days in the untreated control animals. The results strongly suggest that CaA could be replaced by any of the commonly used Ca salts for curtailing the WBR of *Sr. CaG which was administered ip, in the *Sr-ip group, was found to be more effective in reducing the WBR of *Sr

  5. Burden of disease and costs of exposure to endocrine disrupting chemicals in the European Union: an updated analysis.

    Science.gov (United States)

    Trasande, L; Zoeller, R T; Hass, U; Kortenkamp, A; Grandjean, P; Myers, J P; DiGangi, J; Hunt, P M; Rudel, R; Sathyanarayana, S; Bellanger, M; Hauser, R; Legler, J; Skakkebaek, N E; Heindel, J J

    2016-07-01

    A previous report documented that endocrine disrupting chemicals contribute substantially to certain forms of disease and disability. In the present analysis, our main objective was to update a range of health and economic costs that can be reasonably attributed to endocrine disrupting chemical exposures in the European Union, leveraging new burden and disease cost estimates of female reproductive conditions from accompanying report. Expert panels evaluated the epidemiologic evidence, using adapted criteria from the WHO Grading of Recommendations Assessment, Development and Evaluation Working Group, and evaluated laboratory and animal evidence of endocrine disruption using definitions recently promulgated by the Danish Environmental Protection Agency. The Delphi method was used to make decisions on the strength of the data. Expert panels consensus was achieved for probable (>20%) endocrine disrupting chemical causation for IQ loss and associated intellectual disability; autism; attention deficit hyperactivity disorder; endometriosis; fibroids; childhood obesity; adult obesity; adult diabetes; cryptorchidism; male infertility, and mortality associated with reduced testosterone. Accounting for probability of causation, and using the midpoint of each range for probability of causation, Monte Carlo simulations produced a median annual cost of €163 billion (1.28% of EU Gross Domestic Product) across 1000 simulations. We conclude that endocrine disrupting chemical exposures in the EU are likely to contribute substantially to disease and dysfunction across the life course with costs in the hundreds of billions of Euros per year. These estimates represent only those endocrine disrupting chemicals with the highest probability of causation; a broader analysis would have produced greater estimates of burden of disease and costs. PMID:27003928

  6. Does long term residency near industry have an impact on the body burden of polychlorinated dibenzo-p-dioxins, furans, and polychlorinated biphenyls in older women?

    OpenAIRE

    Pless-Mulloli, T; Edwards, R; Howel, D; Wood, R.; Paepke, O; Herrmann, T.

    2005-01-01

    Background: For the retrospective study of environment and health linkages biomarkers of exposure are required. Polychlorinated dibenzo-dioxins and furans (PCDD/F) and polychlorinated biphenyls (PCBs) have been useful markers in some settings. This is the first study of PCDD/F body burden in a population based sample from the UK.

  7. Spatial and temporal distributions of contaminant body burden and disease in Gulf of Mexico oyster populations: The role of local and large-scale climatic controls

    Science.gov (United States)

    Wilson, E. A.; Powell, E. N.; Wade, T. L.; Taylor, R. J.; Presley, B. J.; Brooks, J. M.

    1992-06-01

    As part of NOAA's Status and Trends Program, oysters were sampled from 43 sites throughout the Gulf of Mexico from Brownsville, Texas, to the Florida Everglades from 1986 to 1989. Oysters were analysed for body burden of a suite of metals and petroleum aromatic hydrocarbons (PAHs), the prevalence and intensity of the oyster pathogen, Perkinsus marinus, and condition index. The contaminants fell into two groups based on the spatial distribution of body burden throughout the Gulf. Arsenic, selenium, mercury and cadmium were characterized by clinal reduction in similarity with distance reminiscent of that followed by mean monthly temperature and precipitation. Zinc, copper, PAHs and silver showed no consistent geographic trend. Within local regions, industrial and agricultural and use and P. marinus prevalence and infection intensity frequently correlated with body burden. Contaminants and biological attributes followed one of three temporal trends. Zinc, copper and PAHs showed concordant shifts over 4 years throughout the eastern and southern Gulf. Mercury and cadmium showed concordant shifts in the northwestern Gulf. Selenium, arsenic, length, condition index and P. marinus prevalence and infection intensity showed concordant shifts throughout most of the entire Gulf. Concordant shifts suggest that climatic factors, the El Niño/Southern Oscillation being one example, exert a strong influence on biological attributes and contaminant body burdens in the Gulf. Correlative factors are those that probably affect or indicate the rate of tissue turnover and the frequency of reproduction; namely, temperature, disease intensity, condition index and length.

  8. Imposex and butyltin body burden in Nassarius nitidus (Jeffreys, 1867), in coastal waters within the Basque Country (northern Spain)

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, J. German, E-mail: grodriguez@pas.azti.es [AZTI-Tecnalia, Herrera Kaia Portualdea z/g, 20110-Pasaia (Spain); Borja, Angel; Franco, Javier [AZTI-Tecnalia, Herrera Kaia Portualdea z/g, 20110-Pasaia (Spain); Garcia Alonso, J. Ignacio [Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Julian Claveria 8, 33006 Oviedo (Spain); Garmendia, Joxe Mikel; Muxika, Inigo [AZTI-Tecnalia, Herrera Kaia Portualdea z/g, 20110-Pasaia (Spain); Sariego, Cristina [Servicio de Espectrometria de Masas, SCT' s, University of Oviedo, Julian Claveria s/n, 33006, Oviedo (Spain); Valencia, Victoriano [AZTI-Tecnalia, Herrera Kaia Portualdea z/g, 20110-Pasaia (Spain)

    2009-07-01

    Levels of imposex (superimposition of male characters, upon females) and the presence of sterile females are assessed in the gastropod Nassarius nitidus (Jeffreys, 1867), at 22 locations in the Basque Country (northern Spain). At 18 of these localities, butyltin bioaccumulation (tributyltin (TBT); dibutyltin; monobutyltin) was analysed using isotope dilution and GC-ICP-MS. Higher imposex levels and TBT body burden were found in confined harbours, with a large vessel traffic or the presence of a fishing fleet or a shipyard. For the first time, four apparently sequential types of aborted capsules are described in this species. Another novelty is the interspecific comparison between imposex intensities in sympatrically living populations of N. nitidus and N. reticulatus. This showed that sensitivity to TBT pollution of both species is relatively similar (in terms of Relative Penis Length Index). Since N. nitidus has a restricted habitat distribution due to its low presence in wave-exposed habitats, its complementary use with other species is recommended for its use in TBT monitoring programmes.

  9. Imposex and butyltin body burden in Nassarius nitidus (Jeffreys, 1867), in coastal waters within the Basque Country (northern Spain).

    Science.gov (United States)

    Rodríguez, J Germán; Borja, Angel; Franco, Javier; García Alonso, J Ignacio; Garmendia, Joxe Mikel; Muxika, Iñigo; Sariego, Cristina; Valencia, Victoriano

    2009-07-01

    Levels of imposex (superimposition of male characters, upon females) and the presence of sterile females are assessed in the gastropod Nassarius nitidus (Jeffreys, 1867), at 22 locations in the Basque Country (northern Spain). At 18 of these localities, butyltin bioaccumulation (tributyltin (TBT); dibutyltin; monobutyltin) was analysed using isotope dilution and GC-ICP-MS. Higher imposex levels and TBT body burden were found in confined harbours, with a large vessel traffic or the presence of a fishing fleet or a shipyard. For the first time, four apparently sequential types of aborted capsules are described in this species. Another novelty is the interspecific comparison between imposex intensities in sympatrically living populations of N. nitidus and N. reticulatus. This showed that sensitivity to TBT pollution of both species is relatively similar (in terms of Relative Penis Length Index). Since N. nitidus has a restricted habitat distribution due to its low presence in wave-exposed habitats, its complementary use with other species is recommended for its use in TBT monitoring programmes. PMID:19410275

  10. Imposex and butyltin body burden in Nassarius nitidus (Jeffreys, 1867), in coastal waters within the Basque Country (northern Spain)

    International Nuclear Information System (INIS)

    Levels of imposex (superimposition of male characters, upon females) and the presence of sterile females are assessed in the gastropod Nassarius nitidus (Jeffreys, 1867), at 22 locations in the Basque Country (northern Spain). At 18 of these localities, butyltin bioaccumulation (tributyltin (TBT); dibutyltin; monobutyltin) was analysed using isotope dilution and GC-ICP-MS. Higher imposex levels and TBT body burden were found in confined harbours, with a large vessel traffic or the presence of a fishing fleet or a shipyard. For the first time, four apparently sequential types of aborted capsules are described in this species. Another novelty is the interspecific comparison between imposex intensities in sympatrically living populations of N. nitidus and N. reticulatus. This showed that sensitivity to TBT pollution of both species is relatively similar (in terms of Relative Penis Length Index). Since N. nitidus has a restricted habitat distribution due to its low presence in wave-exposed habitats, its complementary use with other species is recommended for its use in TBT monitoring programmes.

  11. Adjustment of a direct method for the determination of man body burden in Pu-239 on by X-ray detection of U-235

    International Nuclear Information System (INIS)

    The use of Pu-239 on a larger scale sets a problem about the contamination measurement by aerosol at lung level. A method of direct measurement of Pu-239 lung burden is possible, thanks to the use of a large area window proportional counter. A counter of such pattern, has been especially carried out for this purpose. The adjustment of the apparatus allows an adequate sensibility to detect a contamination at the maximum permissible body burden level. Besides, a method for individual 'internal calibration', with a plutonium mock: the protactinium-233, is reported. (author)

  12. The significance of mineral pollutants in hair for the assessment of the body burden and the concentration in the critical organs in laboratory animals

    International Nuclear Information System (INIS)

    If the content of an element in hair of an individual is used for the assessment of health risk of that person it is of special importance to know if the hair analytical data reflect the body burden or the content of the organ or tissues at risk. Ideally the content in hair should rise and fall in parallel to an increase or decrease of the body burden or the content in the critical organs. It was the aim of this project to study the transfer of Hg, methyl-mercury and Zn to hair and to compare it with the levels simultaneously observed in the total body and the relevant organs under controlled experimental conditions in an animal model. In addition, a similar study on As and the analyses of two experiments of a long term study on Cd exposure were also included. 11 refs, 3 figs, 4 tabs

  13. Estimating Burden and Disease Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union

    DEFF Research Database (Denmark)

    Trasande, Leonardo; Zoeller, R. Thomas; Hass, Ulla;

    2015-01-01

    Rapidly increasing evidence has documented that endocrine-disrupting chemicals (EDCs) contribute substantially to disease and disability. Objective: The objective was to quantify a range of health and economic costs that can be reasonably attributed to EDC exposures in the European Union (EU......). Design: A Steering Committee of scientists adapted the Intergovernmental Panel on Climate Change weight-of-evidence characterization for probability of causation based upon levels of available epidemiological and toxicological evidence for one or more chemicals contributing to disease by an endocrine...... Environmental Protection Agency for evaluating laboratory and animal evidence of endocrine disruption. Expert panels used the Delphi method to make decisions on the strength of the data. Results: Expert panels achieved consensus at least for probable (>20%) EDC causation for IQ loss and associated intellectual...

  14. Increased body mass index in ankylosing spondylitis is associated with greater burden of symptoms and poor perceptions of the benefits of exercise

    OpenAIRE

    Wilson, Fiona

    2014-01-01

    PUBLISHED OBJECTIVE: Increased body mass index (BMI) in patients with ankylosing spondylitis (AS) is associated with a greater burden of symptoms and poor perceptions of the benefits of exercise. In AS, the effect of obesity on disease characteristics and exercise perceptions is unknown. We evaluated the prevalence of obesity in AS, to assess the attitudes of patients toward exercise and to evaluate the effect of obesity on symptoms and disease activity. METHODS: Demographic dat...

  15. Thyroid endocrine status of wild European eels (Anguilla anguilla) in the Loire (France). Relationships with organic contaminant body burdens.

    Science.gov (United States)

    Couderc, M; Marchand, J; Zalouk-Vergnoux, A; Kamari, A; Moreau, B; Blanchet-Letrouvé, I; Le Bizec, B; Mouneyrac, C; Poirier, L

    2016-04-15

    In teleost fish, thyroid function is involved in various critical physiological processes. Given the complexity of the hypothalamo-pituitary-thyroid (HPT) axis, a large number of genes and proteins can be the potential target of endocrine-disrupting compounds (EDCs). The aim of this study was to evaluate, in yellow and silver European eels (Anguilla anguilla), potential effects of EDCs on thyroid status by analyzing the associations between EDC body burdens and thyroid hormones (THs). In yellow individuals, greater free T3/T4 ratios (FT3/FT4) and lower plasma FT4 levels were associated with greater concentrations of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), as highlighted by significant correlations with many congeners. Few positive relationships with alkylphenols were noticed. In contrast, silver eels usually exhibited less significant correlations between THs and contaminant loads. Expression of a series of genes involved in the HPT axis was also investigated in the silver individuals. Concerning mRNA expression in silver females, some main correlations were noticed: thyroid-stimulating hormone (TSHβ) gene expression was significantly correlated to numerous PCBs, and hepatic mRNA levels of deiodinase 2 (Deio 2) were negatively correlated to 2-hydroxyfluorene (2-OHF) and 2-naphtol (2-OHNa). Thyroid receptor (TRα and TRβ) mRNA levels exhibited weak negative correlations with some PBDEs in silver females and males. Hepatic vitellogenin (Vtg) mRNA levels were detected in all silver males but at lower levels than in silver females. In males, Vtg mRNA levels were positively associated to FT4/TT4. In silver females, strong positive correlations were found between congeners of PCBs, PBDEs and PFAS suggesting potential estrogenic effects. Overall, the observed results indicate that several organic contaminants, mainly dl-, ndl-PCBs and PBDEs, could be associated with changes in thyroid homeostasis in these fish, via direct or indirect

  16. Chemical heterogeneities in the interior of terrestrial bodies

    Science.gov (United States)

    Plesa, Ana-Catalina; Maurice, Maxime; Tosi, Nicola; Breuer, Doris

    2016-04-01

    Mantle chemical heterogeneities that can strongly influence the interior dynamics have been inferred for all terrestrial bodies of the Solar System and range from local to global scale. Seismic data for the Earth, differences in surface mineral compositions observed in data sets from space missions, and isotopic variations identified in laboratory analyses of meteorites or samples indicate chemically heterogeneous systems. One way to generate large scale geochemical heterogeneities is through the fractional crystallization of a liquid magma ocean. The large amount of energy available in the early stages of planetary evolution can cause melting of a significant part or perhaps even the entire mantle of a terrestrial body resulting in a liquid magma ocean. Assuming fractional crystallization, magma ocean solidification proceeds from the core-mantle boundary to the surface where dense cumulates tend to form due to iron enrichment in the evolving liquid. This process leads to a gravitationally unstable mantle, which is prone to overturn. Following cumulate overturn, a stable stratification may be reached that prevents efficient material transport. As a consequence, mantle reservoirs may be kept separate, possibly for the entire thermo-chemical evolution of a terrestrial body. Scenarios assuming fractional crystallization of a liquid magma ocean have been suggested to explain lavas with distinct composition on Mercury's surface [1], the generation of the Moon's mare basalts by sampling a reservoir consisting of overturned ilmenite-bearing cumulates [2], and the preservation of Mars' geochemical reservoirs as inferred by isotopic analysis of the SNC meteorites [3]. However, recent studies have shown that the style of the overturn as well as the subsequent density stratification are of extreme importance for the subsequent thermo-chemical evolution of a planetary body and may have a major impact on the later surface tectonics and volcanic history. The rapid formation of a

  17. Effects of liquid paraffin in the diet or infused via colonic enema on fecal elimination of 14C-hexachlorobenzene from body burdens in rats

    International Nuclear Information System (INIS)

    Twenty-one male rats were dosed once intraperitoneally with 32.2 mg 14C-hexachlorobenzene in corn oil (14C-HCB activity 11.67 μCi/rat). After 4 d, six rats were randomly selected, bled and hemi-castrated with sampling of epididymal adipose tissue to establish 14C-HCB body burdens. Thereafter, all rats were allocated randomly into three groups, each with five intact and two hemi-castrated rats. One group (controls) received only a basal diet; another received the basal diet amended with 5% light mineral oil (MO); and the third received the basal diet and 1 ml of MO once daily via enema in the upper colon. Treatments were continued throughout 27 d. Excretion of 14C-HCB and(or) metabolites into feces and urine was measured daily for each rat for 31 d after 14C-HCB dosage. Fecal excretion of 14C-HCB and(or) metabolites was increased 2.5-fold by dietary MO and 1.7-fold by MO in the colon. When adjusted to equal dosage, MO by colon was 93% as effective as MO by diet. Urinary 14C-HCB excretion was not affected by MO, except indirectly through lowered body burden. Addition of hexadecane (25 μl per 100 mg adipose tissue) into the incubation mixture enhanced (P 14C-HCB into the liquid fraction for rats not previously fed hexadecane, but had no effect on incubation mixtures from rats fed hexadecane. Results confirm that liquid paraffins enhance elimination of 14C-HCB from body burdens into feces and suggest that distribution into blood cells and plasma may partially explain the effect

  18. A review of environmental fate, body burdens, and human health risk assessment of PCDD/Fs at two typical electronic waste recycling sites in China

    Energy Technology Data Exchange (ETDEWEB)

    Chan, Janet Kit Yan, E-mail: chanjky@hku.hk [School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong (China); Wong, Ming H., E-mail: mhwong@hkbu.edu.hk [Croucher Institute for Environmental Sciences, and Department of Biology, Hong Kong Baptist University, Hong Kong (China)

    2013-10-01

    This paper reviews the levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in different environmental media, human body burdens and health risk assessment results at e-waste recycling sites in China. To provide an indication of the seriousness of the pollution levels in the e-waste recycling sites in China, the data are compared with guidelines and available existing data for other areas. The comparison clearly shows that PCDD/Fs derived from the recycling processes lead to serious pollution in different environmental compartments (such as air, soil, sediment, dust and biota) and heavy body burdens. Of all kinds of e-waste recycling operations, open burning of e-waste and acid leaching activities are identified as the major sources of PCDD/Fs. Deriving from the published data, the estimated total exposure doses via dietary intake, inhalation, soil/dust ingestion and dermal contact are calculated for adults, children and breast-fed infants living in two major e-waste processing locations in China. The values ranged from 5.59 to 105.16 pg WHO-TEQ/kg bw/day, exceeding the tolerable daily intakes recommended by the WHO (1–4 pg WHO-TEQ/kg bw/day). Dietary intake is the most important exposure route for infants, children and adults living in these sites, contributing 60–99% of the total intakes. Inhalation is the second major exposure route, accounted for 12–30% of the total exposure doses of children and adults. In order to protect the environment and human health, there is an urgent need to control and monitor the informal e-waste recycling operations. Knowledge gaps, such as comprehensive dietary exposure data, epidemiological and clinical studies, body burdens of infants and children, and kinetics about PCDD/Fs partitions among different human tissues should be addressed. - Highlights: ► PCDD/F levels at e-waste recycling sites in China were reviewed. ► Data on environment and body burden and health risk assessment results were reviewed

  19. A review of environmental fate, body burdens, and human health risk assessment of PCDD/Fs at two typical electronic waste recycling sites in China

    International Nuclear Information System (INIS)

    This paper reviews the levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in different environmental media, human body burdens and health risk assessment results at e-waste recycling sites in China. To provide an indication of the seriousness of the pollution levels in the e-waste recycling sites in China, the data are compared with guidelines and available existing data for other areas. The comparison clearly shows that PCDD/Fs derived from the recycling processes lead to serious pollution in different environmental compartments (such as air, soil, sediment, dust and biota) and heavy body burdens. Of all kinds of e-waste recycling operations, open burning of e-waste and acid leaching activities are identified as the major sources of PCDD/Fs. Deriving from the published data, the estimated total exposure doses via dietary intake, inhalation, soil/dust ingestion and dermal contact are calculated for adults, children and breast-fed infants living in two major e-waste processing locations in China. The values ranged from 5.59 to 105.16 pg WHO-TEQ/kg bw/day, exceeding the tolerable daily intakes recommended by the WHO (1–4 pg WHO-TEQ/kg bw/day). Dietary intake is the most important exposure route for infants, children and adults living in these sites, contributing 60–99% of the total intakes. Inhalation is the second major exposure route, accounted for 12–30% of the total exposure doses of children and adults. In order to protect the environment and human health, there is an urgent need to control and monitor the informal e-waste recycling operations. Knowledge gaps, such as comprehensive dietary exposure data, epidemiological and clinical studies, body burdens of infants and children, and kinetics about PCDD/Fs partitions among different human tissues should be addressed. - Highlights: ► PCDD/F levels at e-waste recycling sites in China were reviewed. ► Data on environment and body burden and health risk assessment results were reviewed

  20. The development of a spatially explicit model to estimate radiocaesium body burdens in raccoons (Procyon lotor) for ecological risk assessment

    International Nuclear Information System (INIS)

    A spatially explicit model of raccoon (Procyon lotor) distribution for the U.S. Department of Energy's (DOE) Savannah River Site (SRS) in west-central South Carolina was developed using data from a raccoon radio-telemetry study and visualized within a Geographic Information System (GIS). An inductive approach was employed to develop three sub-models using the ecological requirements of raccoons studied in the following habitats: (1) man-made reservoirs (2) bottomland hardwood/riverine systems, and (3) isolated wetland systems. Logistic regression was used to derive probabilistic resource selection functions using habitat compositional data and landscape metrics. The final distribution model provides a spatially explicit probability (likelihood of being in an area) surface for male raccoons. The model is a stand-alone tool consisting of algorithms independent of the specific GIS data layers to which they were derived. The model was then used to predict contaminant burdens in raccoons inhabiting a riverine system contaminated with radiocaesium (137Cs). The predicted 137Cs burdens were less than if one would assume homogeneous use of the contaminated areas. This modelling effort provides a template for DOE managed lands and other large government facilities to establish a framework for site-specific ecological assessments that use wildlife species as endpoints

  1. The development of a spatially explicit model to estimate radiocaesium body burdens in raccoons (Procyon lotor) for ecological risk assessment

    Energy Technology Data Exchange (ETDEWEB)

    Gaines, Karen F. [University of South Carolina, Norman J. Arnold School of Public Health, Columbia, SC 29208 (United States) and University of Georgia, Savannah River Ecology Laboratory, Aiken, SC 29802 (United States) and Consortium for Risk Evaluation with Stakeholder Participation, Environmental and Occupational Health Sciences Institute, Piscataway, NJ (United States)]. E-mail: kfgaines@usd.edu; Boring, C. Shane [Consortium for Risk Evaluation with Stakeholder Participation, Environmental and Occupational Health Sciences Institute, Piscataway, NJ (United States); Division of Life Sciences, Rutgers University, Piscataway, NJ (United States); Porter, Dwayne E. [University of South Carolina, Norman J. Arnold School of Public Health, Columbia, SC 29208 (United States)

    2005-04-01

    A spatially explicit model of raccoon (Procyon lotor) distribution for the U.S. Department of Energy's (DOE) Savannah River Site (SRS) in west-central South Carolina was developed using data from a raccoon radio-telemetry study and visualized within a Geographic Information System (GIS). An inductive approach was employed to develop three sub-models using the ecological requirements of raccoons studied in the following habitats: (1) man-made reservoirs (2) bottomland hardwood/riverine systems, and (3) isolated wetland systems. Logistic regression was used to derive probabilistic resource selection functions using habitat compositional data and landscape metrics. The final distribution model provides a spatially explicit probability (likelihood of being in an area) surface for male raccoons. The model is a stand-alone tool consisting of algorithms independent of the specific GIS data layers to which they were derived. The model was then used to predict contaminant burdens in raccoons inhabiting a riverine system contaminated with radiocaesium ({sup 137}Cs). The predicted {sup 137}Cs burdens were less than if one would assume homogeneous use of the contaminated areas. This modelling effort provides a template for DOE managed lands and other large government facilities to establish a framework for site-specific ecological assessments that use wildlife species as endpoints.

  2. Association of PCB, PBDE and PCDD/F body burdens with hormone levels for children in an e-waste dismantling area of Zhejiang Province, China

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Peiwei, E-mail: pwxu@cdc.zj.cn; Lou, Xiaoming; Ding, Gangqiang; Shen, Haitao; Wu, Lizhi; Chen, Zhijian; Han, Jianlong; Han, Guangen; Wang, Xiaofeng, E-mail: zjcdcwxf@gmail.com

    2014-11-15

    Increased electronic waste (e-waste) has raised public concerns regarding exposure to numerous toxic contaminants, particularly polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). In China, the body burdens of PCBs, PBDEs and PCDD/Fs are associated with thyroid hormones in populations from e-waste dismantling sites; however, it is unclear whether this association occurs in children. In this study, we determined the serum levels of PCBs, PBDEs and PCDD/Fs and the endocrine hormones including free triiodothyronine (FT3), total triiodothyronine (TT3), free thyroxine (FT4), total thyroxine (TT4), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), cortisol and growth hormone (GH) in 21 children from an e-waste dismantling area and 24 children from a control area. The results showed that the mean levels of ∑ PCBs and ∑ PBDEs in the exposure group were significantly higher than in the control group (40.56 and 32.09 ng g{sup −1} lipid vs. 20.69 and 8.43 ng g{sup −1} lipid, respectively, p < 0.01 for each), and the mean level of ∑ PCDD/Fs in the exposure group was higher than in the control group, but the difference was not significant (206.17 vs. 160.27 pg g{sup −1} lipid, p > 0.05). For the endocrine hormones, we did not find significant differences between the exposed and control groups, although the mean levels of FT3, TT3, TT4, ACTH, cortisol and GH were higher, whereas the mean levels of FT4 and TSH were lower in the exposed group. The mean level of ∑ PBDEs was positively correlated with the mean levels of ∑ PCBs (r = 0.60, p < 0.05) and ∑ PCDD/Fs (r = 0.61, p < 0.05). Furthermore, the mean level of ∑ PBDEs was positively correlated with ACTH (r = 0.61, p < 0.05). In conclusion, our data suggested that exposure to e-waste dismantling environment increased the body burdens of PCBs and PBDEs in local children and that these contaminants

  3. Association of PCB, PBDE and PCDD/F body burdens with hormone levels for children in an e-waste dismantling area of Zhejiang Province, China

    International Nuclear Information System (INIS)

    Increased electronic waste (e-waste) has raised public concerns regarding exposure to numerous toxic contaminants, particularly polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). In China, the body burdens of PCBs, PBDEs and PCDD/Fs are associated with thyroid hormones in populations from e-waste dismantling sites; however, it is unclear whether this association occurs in children. In this study, we determined the serum levels of PCBs, PBDEs and PCDD/Fs and the endocrine hormones including free triiodothyronine (FT3), total triiodothyronine (TT3), free thyroxine (FT4), total thyroxine (TT4), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), cortisol and growth hormone (GH) in 21 children from an e-waste dismantling area and 24 children from a control area. The results showed that the mean levels of ∑ PCBs and ∑ PBDEs in the exposure group were significantly higher than in the control group (40.56 and 32.09 ng g−1 lipid vs. 20.69 and 8.43 ng g−1 lipid, respectively, p < 0.01 for each), and the mean level of ∑ PCDD/Fs in the exposure group was higher than in the control group, but the difference was not significant (206.17 vs. 160.27 pg g−1 lipid, p > 0.05). For the endocrine hormones, we did not find significant differences between the exposed and control groups, although the mean levels of FT3, TT3, TT4, ACTH, cortisol and GH were higher, whereas the mean levels of FT4 and TSH were lower in the exposed group. The mean level of ∑ PBDEs was positively correlated with the mean levels of ∑ PCBs (r = 0.60, p < 0.05) and ∑ PCDD/Fs (r = 0.61, p < 0.05). Furthermore, the mean level of ∑ PBDEs was positively correlated with ACTH (r = 0.61, p < 0.05). In conclusion, our data suggested that exposure to e-waste dismantling environment increased the body burdens of PCBs and PBDEs in local children and that these contaminants released from the e

  4. The effects of different oil spill cleanup technologies on body burden and biomarkers in Arctic marine organisms - a laboratory study

    Energy Technology Data Exchange (ETDEWEB)

    Faksness, Liv-Guri; Hansen, Bjorn Henrik; Nordtug, Trond [SINTEF Materials and Chemistry (Norway)], email: livgurif@sintef.no; Borseth, Jan Fredrik; Baussant, Thierry; Tandberg, Anne Helene S.; Ingvarsdottir, Anna; Aarab, Nadia [IRIS Biomiljo (Norway); Altin, Dag [Altins BioTrix (Norway)

    2011-07-01

    This paper studies the effects and toxicity of a water soluble fraction (WSF) of oil versus chemically dispersed oil and also of WSF versus the underlying water after in situ burning (ISB). The applications of exposure concentrations were based on monitoring of WSF in the water column during an offshore field experiment. A continuous flow-through system for the dispersant experiments was set up and an Arctic amphipod was used as the test species. Seawater and gammarids were also used as samples for chemical and biological analyses. Good correlation with the data was presented by chemical analysis of the water samples. However, more PAHs (Polycyclic Aromatic Hydrocarbons) were measured in the gammarids exposed to oil mixed with dispersant than in those exposed to oil alone. On the other hand, a system was developed to allow water sampling after ISB and samples of seawater and of oil prior to, and immediately after, ISB were collected and a chemical analysis was conducted. The result of the analysis was that there was no increase in toxicity in the underlying water after ISB.

  5. Common Carotid Intima Media Thickness and Ankle-Brachial Pressure Index Correlate with Local but Not Global Atheroma Burden: A Cross Sectional Study Using Whole Body Magnetic Resonance Angiography

    OpenAIRE

    Weir-McCall, Jonathan R.; Khan, Faisel; Lambert, Matthew A.; Carly L Adamson; Gardner, Michael; Gandy, Stephen J.; Ramkumar, Prasad Guntur; Belch, Jill J. F.; Struthers, Allan D.; Rauchhaus, Petra; Andrew D Morris; Houston, J. Graeme

    2014-01-01

    Background Common carotid intima media thickness (CIMT) and ankle brachial pressure index (ABPI) are used as surrogate marker of atherosclerosis, and have been shown to correlate with arterial stiffness, however their correlation with global atherosclerotic burden has not been previously assessed. We compare CIMT and ABPI with atheroma burden as measured by whole body magnetic resonance angiography (WB-MRA). Methods 50 patients with symptomatic peripheral arterial disease were recruited. CIMT...

  6. Common carotid intima media thickness and ankle-brachial pressure index correlate with local but not global atheroma burden:A cross sectional study using whole body magnetic resonance angiography

    OpenAIRE

    Weir-McCall, Jonathan R.; Khan, Faisel; Lambert, Matthew A.; Carly L Adamson; Gardner, Michael; Gandy, Stephen J.; Ramkumar, Prasad Guntur; Belch, Jill J. F.; Struthers, Allan D.; Rauchhaus, Petra; Andrew D Morris; Houston, J. Graeme

    2014-01-01

    Background: Common carotid intima media thickness (CIMT) and ankle brachial pressure index (ABPI) are used as surrogate marker of atherosclerosis, and have been shown to correlate with arterial stiffness, however their correlation with global atherosclerotic burden has not been previously assessed. We compare CIMT and ABPI with atheroma burden as measured by whole body magnetic resonance angiography (WB-MRA). Methods: 50 patients with symptomatic peripheral arterial disease were recruited. CI...

  7. Evaluation of the suitability of application of golden jackal (Canis aureus) hair as a noninvasive technique for determination of body burden mercury.

    Science.gov (United States)

    Malvandi, Hassan; Ghasempouri, Seyed Mahmoud; Esmaili-Sari, Abbas; Bahramifar, Nader

    2010-08-01

    An evaluation of suitability of applying hair as a noninvasive indicator for determination of the body burden mercury in mammals was carried out by determining the concentration of mercury in hair and liver tissue of the golden jackal, Canis aureus . Nineteen jackals killed on the roads along the Caspian Sea in the central region of Mazandaran Province, Iran were collected. The mercury measurements were carried out by AMA254 LECO and the standard method ASTM-D6722. SPSS and Excel were used for analytical statistics. There was a significant difference in Hg levels between the hair and liver tissue (P < 0.001). The average concentration of mercury was 187.3 + or - 22.7 and 53.3 + or - 7.3 ng/g, respectively. No significant differences were seen either between the sexes or in correlation between the tissues. But a significant and positive relation was seen between the mercury content in hair and body weight and length (P < 0.005). In general, the mercury concentration was less than the deleterious, effective limit on the species. It seems that this is the first study of Hg concentrations in jackals and demonstrates on easy and noninvasive sampling method. PMID:20596768

  8. Chemical compositions of the moon, earth, and eucrite parent body

    Science.gov (United States)

    Anders, E.

    1977-01-01

    Model compositions of the moon and earth were calculated on the assumption that these planets had experienced chondrite-like nebular fractionation processes. The model correctly predicts the abundance ratios of certain volatile/refractory element pairs (e.g., Cd/Ba, Ga/La, Sn/Th, and Pb/U), the density of the moon, and the major rock types. The model is also used to reconstruct the composition of the parent eucrite body, which resembles the moon except for a lower content of refractory elements.

  9. Burden of disease and costs of exposure to endocrine disrupting chemicals in the European Union: an updated analysis

    DEFF Research Database (Denmark)

    Trasande, L.; Zoeller, R. T.; Hass, Ulla;

    2016-01-01

    A previous report documented that endocrine disrupting chemicals contribute substantially to certain forms of disease and disability. In the present analysis, our main objective was to update a range of health and economic costs that can be reasonably attributed to endocrine disrupting chemical...... Group, and evaluated laboratory and animal evidence of endocrine disruption using definitions recently promulgated by the Danish Environmental Protection Agency. The Delphi method was used to make decisions on the strength of the data. Expert panels consensus was achieved for probable (>20%) endocrine...... disrupting chemical causation for IQ loss and associated intellectual disability; autism; attention deficit hyperactivity disorder; endometriosis; fibroids; childhood obesity; adult obesity; adult diabetes; cryptorchidism; male infertility, and mortality associated with reduced testosterone. Accounting...

  10. Evaluation of 137Cs body burden in inhabitants of Bryansk Oblast, Russian Federation, where a high incidence of thyroid cancer was observed after the accident at the Chernobyl nuclear power plant

    International Nuclear Information System (INIS)

    To determine the current risk of internal radiation exposure after the Chernobyl accident, the 137Cs body burden of the inhabitants of Bryansk Oblast (Russian Federation) was evaluated, from 1998 to 2008. The study population is composed of 84 666 people who visited Bryansk No. 2 Hospital. A whole-body counter was used for measurement of 137Cs body burden. 137Cs concentration was significantly higher in the late period during the study and showed seasonal variation, suggesting that inhabitants may have consumed contaminated forest products. However, people with high annual exposure doses were quite rare during all years of the study. In conclusion, although internal radiation exposure from 137Cs continues to this day in Bryansk Oblast, the annual exposure dose is low in almost all inhabitants. Because of the long half-life of 137Cs, the long term follow-up is necessary to monitor the health status and relieve the anxiety of the inhabitants around Chernobyl. (authors)

  11. Common carotid intima media thickness and ankle-brachial pressure index correlate with local but not global atheroma burden: a cross sectional study using whole body magnetic resonance angiography.

    Directory of Open Access Journals (Sweden)

    Jonathan R Weir-McCall

    Full Text Available Common carotid intima media thickness (CIMT and ankle brachial pressure index (ABPI are used as surrogate marker of atherosclerosis, and have been shown to correlate with arterial stiffness, however their correlation with global atherosclerotic burden has not been previously assessed. We compare CIMT and ABPI with atheroma burden as measured by whole body magnetic resonance angiography (WB-MRA.50 patients with symptomatic peripheral arterial disease were recruited. CIMT was measured using ultrasound while rest and exercise ABPI were performed. WB-MRA was performed in a 1.5T MRI scanner using 4 volume acquisitions with a divided dose of intravenous gadolinium gadoterate meglumine (Dotarem, Guerbet, FR. The WB-MRA data was divided into 31 anatomical arterial segments with each scored according to degree of luminal narrowing: 0 = normal, 1 = <50%, 2 = 50-70%, 3 = 70-99%, 4 = vessel occlusion. The segment scores were summed and from this a standardized atheroma score was calculated.The atherosclerotic burden was high with a standardised atheroma score of 39.5±11. Common CIMT showed a positive correlation with the whole body atheroma score (β 0.32, p = 0.045, however this was due to its strong correlation with the neck and thoracic segments (β 0.42 p = 0.01 with no correlation with the rest of the body. ABPI correlated with the whole body atheroma score (β -0.39, p = 0.012, which was due to a strong correlation with the ilio-femoral vessels with no correlation with the thoracic or neck vessels. On multiple linear regression, no correlation between CIMT and global atheroma burden was present (β 0.13 p = 0.45, while the correlation between ABPI and atheroma burden persisted (β -0.45 p = 0.005.ABPI but not CIMT correlates with global atheroma burden as measured by whole body contrast enhanced magnetic resonance angiography in a population with symptomatic peripheral arterial disease. However this is

  12. Changes in body chemical composition with age measured by total-body neutron activation

    International Nuclear Information System (INIS)

    Total-body levels of calcium and phosphorus (reflecting skeletal mass) and total-body levels of potassium (reflecting muscle mass) were measured by neutron activation analysis in 39 men and 40 women ages 30 to 90 yr. In order to intercompare the total body calcium (TBCa) values in a heterogeneous population, such as this, it was necessary to normalize the data for skeletal size. The normalization consisted of dividing the absolute calcium level by the predicted calcium level for each individual matched to a set of critical parameters. The parameter used in the computation of normal values were age, sex, muscle mass, i.e., total body potassium (TBK) and height. For the calcium data of the women, it was necessary to add an age correction factor after the age of 55 yr. The calcium ratio (mean ratio of the predicted to measured TBCa) in men was 1.000 +- 7.8 percent and in women 0.996 +- 7.1 percent. The TBCa of normal males and females can thus be predicted to +-13 percent (at the 90 percent confidence level). An exception to this was found in males (70 to 90 yr) who exhibited a mean calcium ratio greater than 1.13

  13. Proposal for a new tomographic device providing information on the chemical properties of a body section

    International Nuclear Information System (INIS)

    A system to analyze the chemical properties of a region of tissue located deep inside the human body without having to access it is proposed. The method is based on a high precision detection of x-rays or γ-rays (photons) from an external source Compton scattered from the tissue under inspection. The method provides chemical information of plane regions lying not too deep inside the body (<6 cm). The amount of radiation absorbed by the body is about the same as needed for a standard x-ray tomography. The exposure time is estimated to be shorter than 10 minutes. 37 refs., 13 figs

  14. Novel associations between contaminant body burdens and biomarkers of reproductive condition in male Common Carp along multiple gradients of contaminant exposure in Lake Mead National Recreation Area, USA.

    Science.gov (United States)

    Patiño, Reynaldo; VanLandeghem, Matthew M; Goodbred, Steven L; Orsak, Erik; Jenkins, Jill A; Echols, Kathy; Rosen, Michael R; Torres, Leticia

    2015-08-01

    Adult male Common Carp were sampled in 2007/08 over a full reproductive cycle at Lake Mead National Recreation Area. Sites sampled included a stream dominated by treated wastewater effluent, a lake basin receiving the streamflow, an upstream lake basin (reference), and a site below Hoover Dam. Individual body burdens for 252 contaminants were measured, and biological variables assessed included physiological [plasma vitellogenin (VTG), estradiol-17β (E2), 11-ketotestosterone (11KT)] and organ [gonadosomatic index (GSI)] endpoints. Patterns in contaminant composition and biological condition were determined by Principal Component Analysis, and their associations modeled by Principal Component Regression. Three spatially distinct but temporally stable gradients of contaminant distribution were recognized: a contaminant mixture typical of wastewaters (PBDEs, methyl triclosan, galaxolide), PCBs, and DDTs. Two spatiotemporally variable patterns of biological condition were recognized: a primary pattern consisting of reproductive condition variables (11KT, E2, GSI), and a secondary pattern including general condition traits (condition factor, hematocrit, fork length). VTG was low in all fish, indicating low estrogenic activity of water at all sites. Wastewater contaminants associated negatively with GSI, 11KT and E2; PCBs associated negatively with GSI and 11KT; and DDTs associated positively with GSI and 11KT. Regression of GSI on sex steroids revealed a novel, nonlinear association between these variables. Inclusion of sex steroids in the GSI regression on contaminants rendered wastewater contaminants nonsignificant in the model and reduced the influence of PCBs and DDTs. Thus, the influence of contaminants on GSI may have been partially driven by organismal modes-of-action that include changes in sex steroid production. The positive association of DDTs with 11KT and GSI suggests that lifetime, sub-lethal exposures to DDTs have effects on male carp opposite of those

  15. Relationship between trace element content in human organs and hair - significance of hair mineral analysis as a means for assessing internal body burdens of environmental mineral pollutants. Final report for the period October 1984 - September 1988

    International Nuclear Information System (INIS)

    The purpose of the project was to establish a possibility to use hair as a monitor for internal body burden with toxic metals. For this purpose samples of human organs (heart, spleen, liver, kidney) and hair were analysed by neutron activation analysis and radiochemical techniques for the determination of As, Cd, Hg, Cu, Zn, Se, Ca, K, Mg, Mn, Na, S. 6 refs, 4 tabs

  16. Chemical Constituents of the Fruiting Bodies of Clitocybe nebularis and Their Antifungal Activity

    OpenAIRE

    Kim, Young-Sook; Lee, In-Kyoung; Seok, Soon-Ja; Yun, Bong-Sik

    2008-01-01

    During a continuing search for antimicrobial substances from Korean native wild mushroom extracts, we found that the methanolic extract of the fruiting body of Clitocybe nebularis exhibited mild antifungal activity against pathogenic fungi. Therefore we evaluated the antifungal substances and other chemical components of the fruiting body of Clitocybe nebularis, which led to the isolation of nebularine, phenylacetic acid, purine, uridine, adenine, uracil, benzoic acid, and mannitol. Nebularin...

  17. A comparison of mercury burdens between St. Marks National Wildlife Refuge and St. Andrew Bay, Florida: Evaluation of fish body burdens and physiological responses in largemouth bass, spotted seatrout, striped mullet, and sunfish

    Science.gov (United States)

    Huge, D.H.; Rauschenberger, R.H.; Wieser, F.M.; Hemming, J.M.

    2011-01-01

    Musculature from the dorsal region of 130 largemouth bass (Micropterus salmoides), 140 sunfish (Lepomis sp.), 41 spotted seatrout (Cynoscion nebulosus) and 67 striped mullet (Mugil cephalus) were collected from five estuarine and five freshwater sites within the St. Marks National Wildlife Refuge and two estuarine and two freshwater sites from St. Andrew Bay, Florida, United States of America. Musculature was analyzed for total mercury content, sagittal otoliths were removed for age determination and physiological responses were measured. Largemouth bass and sunfish from the refuge had higher mercury concentrations in musculature than those from the bay. Male spotted seatrout, male striped mullet, male and female sunfish and female largemouth bass had mercury burdens positively correlated with length. The majority of all four species of fish from both study areas contained mercury levels below 1.5 part per million, the limit for safe consumption recommended the Florida Department of Health. In comparison, a significant percentage of largemouth bass and sunfish from several sampled sites, most notably Otter Lake and Lake Renfroe within St. Marks National Wildlife Refuge, had mercury levels consistent with the health department's guidelines of 'limited consumption' or 'no consumption guidelines.'

  18. Efficient inclusion body processing using chemical extraction and high gradient magnetic fishing

    DEFF Research Database (Denmark)

    Heebøll-Nielsen, Anders; Choe, W.S.; Middelberg, A.P.J.; Thomas, Owen R. T.

    2003-01-01

    In this study we introduce a radical new approach for the recovery of proteins expressed in the form of inclusion bodies, involving W chemical extraction from the host cells, (ii) adsorptive capture of the target protein onto small magnetic adsorbents, and (iii) subsequent rapid collection of the...

  19. Chemical profiles of body surfaces and nests from six Bornean stingless bee species.

    Science.gov (United States)

    Leonhardt, Sara Diana; Blüthgen, Nico; Schmitt, Thomas

    2011-01-01

    Stingless bees (Apidae: Meliponini) are the most diverse group of Apid bees and represent common pollinators in tropical ecosystems. Like honeybees they live in large eusocial colonies and rely on complex chemical recognition and communication systems. In contrast to honeybees, their ecology and especially their chemical ecology have received only little attention, particularly in the Old World. We previously have analyzed the chemical profiles of six paleotropical stingless bee species from Borneo and revealed the presence of species-specific cuticular terpenes- an environmentally derived compound class so far unique among social insects. Here, we compared the bees' surface profiles to the chemistry of their nest material. Terpenes, alkanes, and alkenes were the dominant compound groups on both body surfaces and nest material. However, bee profiles and nests strongly differed in their chemical composition. Body surfaces thus did not merely mirror nests, rendering a passive compound transfer from nests to bees unlikely. The difference between nests and bees was particularly pronounced when all resin-derived compounds (terpenes) were excluded and only genetically determined compounds were considered. When terpenes were included, bee profiles and nest material still differed, because whole groups of terpenes (e.g., sesquiterpenes) were found in nest material of some species, but missing in their chemical profile, indicating that bees are able to influence the terpene composition both in their nests and on their surfaces. PMID:21165680

  20. 137Cs radiation burden on children from a highly contaminated area of Belarus

    International Nuclear Information System (INIS)

    The radiation burden from 137Cs sources on 22 children from a small Byelorussian village was studied from 1992 to 1994. Foodstuff, whole body burden and urinary excretion of 137Cs were measured, intake rates, biological half-lives and doses were calculated. The median value for the 137Cs whole body incorporation level was found to be 124 Bq, the biological half life was calculated as 68 d for girls and 50 d for boys. The internal dose caused by 137Cs was found to be negligible in comparison to that from external sources. No deviation from normal values could be shown in simultaneously studied clinico-chemical parameters

  1. Chemical composition of whole body and carcass of Bos indicus and tropically adapted Bos taurus breeds.

    Science.gov (United States)

    Bonilha, S F M; Tedeschi, L O; Packer, I U; Razook, A G; Nardon, R F; Figueiredo, L A; Alleoni, G F

    2011-09-01

    Relationships between the chemical composition of the 9th- to 11th-rib section and the chemical composition of the carcass and empty body were evaluated for Bos indicus (108 Nellore and 36 Guzerah; GuS) and tropically adapted Bos taurus (56 Caracu; CaS) bulls, averaging 20 to 24 mo of age at slaughter. Nellore cattle were represented by 56 animals from the selected herd (NeS) and 52 animals from the control herd (NeC). The CaS and GuS bulls were from selected herds. Selected herds were based on 20 yr of selection for postweaning BW. Carcass composition was obtained after grinding, homogenizing, sampling, and analyzing soft tissue and bones. Similarly, empty body composition was obtained after grinding, homogenizing, sampling, analyzing, and combining blood, hide, head + feet, viscera, and carcass. Bulls were separated into 2 groups. Group 1 was composed of 36 NeS, 36 NeC, 36 CaS, and 36 GuS bulls and had water, ether extract (EE), protein, and ash chemically determined in the 9th- to 11th-rib section and in the carcass. Group 2 was composed of 20 NeS, 16 NeC, and 20 CaS bulls and water, EE, protein, and ash were determined in the 9th- to 11th-rib section, carcass, and empty body. Linear regressions were developed between the carcass and the 9th- to 11th-rib section compositions for group 1 and between carcass and empty body compositions for group 2. The 9th- to 11th-rib section percentages of water (RWt) and EE (RF) predicted the percentages of carcass water (CWt) and carcass fat (CF) with high precision: CWt, % = 29.0806 + 0.4873 × RWt, % (r(2) = 0.813, SE = 1.06) and CF, % = 10.4037 + 0.5179 × RF, % (r(2) = 0.863, SE = 1.26), respectively. Linear regressions between percentage of CWt and CF and empty body water (EBWt) and empty body fat (EBF) were also predicted with high precision: EBWt, % = -9.6821 + 1.1626 × CWt, % (r(2) = 0.878, SE = 1.43) and EBF, % = 0.3739 + 1.0386 × CF, % (r(2) = 0.982, SE = 0.65), respectively. Chemical composition of the 9th- to 11

  2. Bioeffects Assessment in Kvichak and Nushagak Bay, Alaska: Characterization of Soft Bottom Benthic Habitats, Animal Body Burdens and Contaminant Baseline Assessment

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The goal of this project is to assess habitat conditions that influence biodiversity and distribution of benthic infaunal communities, contaminants, and chemical...

  3. Bioeffects Assessment in Kvichak and Nushagak Bay, Alaska: Characterization of Soft Bottom Benthic Habitats, Fish Body Burdens and Contaminant Baseline Assessment

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The goal of this project is to assess habitat conditions that influence biodiversity and distribution of benthic infaunal communities, contaminants, and chemical...

  4. Study on raw material origin of celadon porcelain bodies from Zhanggongxiang kiln and Qingliangsi kiln by chemical composition

    International Nuclear Information System (INIS)

    The proton induced X-ray emission (PIXE) was used to measure seven major chemical composition of celadon porcelain body from Qingliangsi kiln in Baofeng and Zhanggongxiang kiln in Ruzhou. The contents of major chemical composition in each sample were selected to make scattering analysis. Their classes and raw material sources were determined. The conclusion is that the raw material origin of Ru porcelain bodies from Qingliangsi kiln in Baofeng is different from that from Zhanggongxiang kiln in Ruzhou, but they are closely related. Both the Ruguan porcelain bodies and MinRu porcelain bodies from Qingliangsi kiln during the Song Dynasty are basically from the same provenance. (authors)

  5. Assessing myeloma bone disease with whole-body diffusion-weighted imaging: comparison with x-ray skeletal survey by region and relationship with laboratory estimates of disease burden

    International Nuclear Information System (INIS)

    Aim: To estimate and compare the extent of myeloma bone disease by skeletal region using whole-body diffusion-weighted imaging (WB-DWI) and skeletal survey (SS) and record interobserver agreement, and to investigate differences in imaging assessments of disease extent and apparent diffusion coefficient (ADC) between patients with pathological high versus low disease burden. Materials and methods: Twenty patients with relapsed myeloma underwent WB-DWI and SS. Lesions were scored by number and size for each skeletal region by two independent observers using WB-DWI and SS. Observer scores, ADC, and ADC-defined volume of tumour-infiltrated marrow were compared between patients with high and low disease burden (assessed by serum paraproteins and marrow biopsy). Results: Observer scores were higher on WB-DWI than SS in every region (p<0.05) except the skull, with greater interobserver reliability in rating the whole skeleton (WB-DWI: ICC = 0.74, 95% CI: 0.443–0.886; SS: ICC = 0.44, 95% CI: 0.002–0.730) and individual body regions. WB-DWI scores were not significantly higher in patients with high versus low disease burden (observer 1: mean ± SD: 48.8 ± 7, 38.6 ± 14.5, observer 2: mean ± SD: 37.3 ± 13.5, 30.4 ± 15.5; p = 0.06, p = 0.35). Conclusion: WB-DWI demonstrated more lesions than SS in all regions except the skull with greater interobserver agreement. Sensitivity is not a limiting factor when considering WB-DWI in the management pathway of patients with myeloma. - Highlights: • WB-DWI demonstrated significantly more lesions than SS in all body regions except the skull. • Inter-observer agreement was better when assessing WB-DWI compared to SS. • Sensitivity is not a limitation of WB-DWI in myeloma

  6. Machine learning predictions of molecular properties: Accurate many-body potentials and nonlocality in chemical space

    International Nuclear Information System (INIS)

    Simultaneously accurate and efficient prediction of molecular properties throughout chemical compound space is a critical ingredient toward rational compound design in chemical and pharmaceutical industries. Aiming toward this goal, we develop and apply a systematic hierarchy of efficient empirical methods to estimate atomization and total energies of molecules. These methods range from a simple sum over atoms, to addition of bond energies, to pairwise interatomic force fields, reaching to the more sophisticated machine learning approaches that are capable of describing collective interactions between many atoms or bonds. In the case of equilibrium molecular geometries, even simple pairwise force fields demonstrate prediction accuracy comparable to benchmark energies calculated using density functional theory with hybrid exchange-correlation functionals; however, accounting for the collective many-body interactions proves to be essential for approaching the 'holy grail' of chemical accuracy of 1 kcal/mol for both equilibrium and out-of-equilibrium geometries. This remarkable accuracy is achieved by a vectorized representation of molecules (so-called Bag of Bonds model) that exhibits strong nonlocality in chemical space. The same representation allows us to predict accurate electronic properties of molecules, such as their polarizability and molecular frontier orbital energies

  7. Human bones obtained from routine joint replacement surgery as a tool for studies of plutonium, americium and 90Sr body-burden in general public

    International Nuclear Information System (INIS)

    The paper presents a new sampling method for studying in-body radioactive contamination by bone-seeking radionuclides such as 90Sr, 239+240Pu, 238Pu, 241Am and selected gamma-emitters, in human bones. The presented results were obtained for samples retrieved from routine surgeries, namely knee or hip joints replacements with implants, performed on individuals from Southern Poland. This allowed to collect representative sets of general public samples. The applied analytical radiochemical procedure for bone matrix is described in details. Due to low concentrations of 238Pu the ratio of Pu isotopes which might be used for Pu source identification is obtained only as upper limits other then global fallout (for example Chernobyl) origin of Pu. Calculated concentrations of radioisotopes are comparable to the existing data from post-mortem studies on human bones retrieved from autopsy or exhumations. Human bones removed during knee or hip joint surgery provide a simple and ethical way for obtaining samples for plutonium, americium and 90Sr in-body contamination studies in general public. - Highlights: → Surgery for joint replacement as novel sampling method for studying in-body radioactive contamination. → Proposed way of sampling is not causing ethic doubts. → It is a convenient way of collecting human bone samples from global population. → The applied analytical radiochemical procedure for bone matrix is described in details. → The opposite patient age correlations trends were found for 90Sr (negative) and Pu, Am (positive).

  8. Human bones obtained from routine joint replacement surgery as a tool for studies of plutonium, americium and {sup 90}Sr body-burden in general public

    Energy Technology Data Exchange (ETDEWEB)

    Mietelski, Jerzy W., E-mail: jerzy.mietelski@ifj.edu.pl [Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Cracow (Poland); Golec, Edward B. [Traumatology and Orthopaedic Clinic, 5th Military Clinical Hospital and Polyclinic, Independent Public Healthcare Facility, Wroclawska 1-3, 30-901 Cracow (Poland); Orthopaedic Rehabilitation Department, Chair of Clinical Rehabilitation, Faculty of Motor of the Bronislaw Czech' s Academy of Physical Education, Cracow (Poland); Department of Physical Therapy Basics, Faculty of Physical Therapy, Administration College, Bielsko-Biala (Poland); Tomankiewicz, Ewa [Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Cracow (Poland); Golec, Joanna [Orthopaedic Rehabilitation Department, Chair of Clinical Rehabilitation, Faculty of Motor of the Bronislaw Czech' s Academy of Physical Education, Cracow (Poland); Physical Therapy Department, Institute of Physical Therapy, Faculty of Heath Science, Jagiellonian University, Medical College, Cracow (Poland); Nowak, Sebastian [Traumatology and Orthopaedic Clinic, 5th Military Clinical Hospital and Polyclinic, Independent Public Healthcare Facility, Wroclawska 1-3, 30-901 Cracow (Poland); Orthopaedic Rehabilitation Department, Chair of Clinical Rehabilitation, Faculty of Motor of the Bronislaw Czech' s Academy of Physical Education, Cracow (Poland); Szczygiel, Elzbieta [Physical Therapy Department, Institute of Physical Therapy, Faculty of Heath Science, Jagiellonian University, Medical College, Cracow (Poland); Brudecki, Kamil [Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Cracow (Poland)

    2011-06-15

    The paper presents a new sampling method for studying in-body radioactive contamination by bone-seeking radionuclides such as {sup 90}Sr, {sup 239+240}Pu, {sup 238}Pu, {sup 241}Am and selected gamma-emitters, in human bones. The presented results were obtained for samples retrieved from routine surgeries, namely knee or hip joints replacements with implants, performed on individuals from Southern Poland. This allowed to collect representative sets of general public samples. The applied analytical radiochemical procedure for bone matrix is described in details. Due to low concentrations of {sup 238}Pu the ratio of Pu isotopes which might be used for Pu source identification is obtained only as upper limits other then global fallout (for example Chernobyl) origin of Pu. Calculated concentrations of radioisotopes are comparable to the existing data from post-mortem studies on human bones retrieved from autopsy or exhumations. Human bones removed during knee or hip joint surgery provide a simple and ethical way for obtaining samples for plutonium, americium and {sup 90}Sr in-body contamination studies in general public. - Highlights: > Surgery for joint replacement as novel sampling method for studying in-body radioactive contamination. > Proposed way of sampling is not causing ethic doubts. > It is a convenient way of collecting human bone samples from global population. > The applied analytical radiochemical procedure for bone matrix is described in details. > The opposite patient age correlations trends were found for 90Sr (negative) and Pu, Am (positive).

  9. Phytocenotic structure and physico-chemical properties of a small water body in agricultural landscape

    Directory of Open Access Journals (Sweden)

    Joanna Sender

    2014-07-01

    Full Text Available Small water bodies, until recently considered as wasteland, are an essential element of the so-called small water retention. Their main use can vary significantly, but they always play a positive role by increasing water resources and enhancing the natural values of the landscape. Moreover, by increasing bio- diversity thanks to plants forming habitats for many species of flora and fauna, small water bodies act as a biofilter, improving water quality. But these small reservoirs belong to the groups of waters that are most exposed to damage, especially within the catchment area. Because of the invaluable role of small farmland water bodies, a study was undertaken to investigate their phytocenotic structure. In addition, an attempt was made to assess the level of threats and to indicate their role in the development of habitat conditions. The investigated reservoir was created in 2007. Before that time, it functioned as a part of the Zemborzycki reservoir, as they were close to each other. Almost the entire surrounding of this small reservoir consisted of farmland. In 2011 a revitalization project was carried out in the reservoir. Plants typical for wetland habitats were mainly introduced, while synanthropic vegetation was removed. Based on chemical and physical analyses, it can be concluded that the investigated reservoir serves as a natural biofilter thanks to the qualitative and quantitative changes in the structure of macrophytes. After the revitalization project, the investigated pond gained new aesthetic and ecological qualities.

  10. Anabolic implant effects on visceral organ mass, chemical body composition, and estimated energetic efficiency in cloned (genetically identical) beef steers.

    Science.gov (United States)

    Hutcheson, J P; Johnson, D E; Gerken, C L; Morgan, J B; Tatum, J D

    1997-10-01

    Six sets of four genetically identical Brangus steers (n = 24; X BW 409 kg) were used to determine the effect of different anabolic implants on visceral organ mass, chemical body composition, estimated tissue deposition, and energetic efficiency. Steers within a clone set were randomly assigned to one of the following implant treatments: C, no implant; E, estrogenic; A, androgenic, or AE, androgenic + estrogenic. Steers were slaughtered 112 d after implanting; visceral organs were weighed and final body composition determined by mechanical grinding and chemical analysis of the empty body. Mass of the empty gastrointestinal tract (GIT) was reduced approximately 9% (P .10) the efficiency of ME utilization. In general, estrogenic implants decreased GIT, androgenic implants increased liver, and all implants increased hide mass. Steers implanted with an AE combination had additive effects on protein deposition compared with either implant alone. The NEg requirements for body gain are estimated to be reduced 19% by estrogenic or combination implants. PMID:9331863

  11. The Global Cancer Burden

    Centers for Disease Control (CDC) Podcasts

    2012-02-02

    This podcast describes the global burden of cancer and efforts by CDC and others to reduce that burden.  Created: 2/2/2012 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 2/2/2012.

  12. Obesity associated noncommunicable disease burden

    Directory of Open Access Journals (Sweden)

    Jyoti Bala Banjare

    2016-01-01

    Full Text Available World is facing rapid transition in health sector for under nutrition and over nutrition. Obesity is a challenging epidemic and increased Body Mass Index (BMI influences on almost all body systems leading to development of non-communicable diseases. Chronic but slow growing non-infectious pathology of body organization give upsurge onset of non-communicable disorders. Obesity related Non-communicable diseases (NCDs leads to millions of deaths all around the world, rapidly becoming economic burden worldwide. Pathophysiology and extend of obesity is responsible for ill effects of health. In obesity Low grade Inflammation and antioxidant disproportion plays vital role in development of NCDs. Effective health education, professional counselling from public health authorities, free health care, and social insurance can be effective in controlling growing non communicable disease globally. The present analysis attempts to study association of obesity with different NCDs in terms of prevalence and underlying mechanisms.

  13. 75 FR 55793 - Cooperative Agreement to Support the Foodborne Disease Burden Epidemiology Reference Group of the...

    Science.gov (United States)

    2010-09-14

    ... international risk assessment and public health efforts involving microbiological and chemical hazards... in specific areas: Infectious diseases, chemicals and toxins, source attribution, and country burden... the estimation of foodborne disease burden where data are lacking; develop cause attribution models...

  14. Analytical quality assessment and interpretation of the trace element data obtained in the frame of the IAEA Co-ordinated Research Programme on the significance of hair mineral analysis as a means for assessing internal body burdens of environmental pollutants

    International Nuclear Information System (INIS)

    At the request of the IAEA, the authors have performed an assessment of the analytical quality and the interpretation of the trace element data obtained within the framework of the IAEA Co-ordinated Research Programme (CRP) on The Significance of Hair Mineral Analysis as a Means of Assessing Internal Body Burdens of Environmental Pollutants. In this CRP research groups from various countries participated, using different analytical procedures, based on NAA, XRF and AAS. Data have been collected for Zn, CU, Pb, Cd, As, Hg, and Se in male human hair, liver, kidney, lung, brain, and bone. The samples analyzed originated from China, Hungary, Bulgaria, Japan, the former GDR, Sweden and Norway. The analytical quality of the data has been assessed on basis of the calculated limits of quantitation per trace element determined, per tissue analyzed and per participant, as well as from the trace element values found for reference materials and ''blind'' materials. The analytical quality of the data differs widely, from generally good to reasonable (Zn, Cu, and Se) to generally inadequate to strongly inadequate (Pb, Cd, As, and Hg). 15 refs, 29 tabs

  15. Simultaneous determination of the Cd and Zn total body burden of individual, nearly microscopic, nanoliter-volume aquatic organisms (Hyalella azteca) by rhenium-cup in-torch vaporization (ITV) sample introduction and axially viewed ICP-AES

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Andrea T.; Badiei, Hamid R.; Karanassios, Vassili [University of Waterloo, Department of Chemistry, Waterloo, ON (Canada); Evans, J. Catherine [University of Waterloo, Department of Biology, Waterloo, ON (Canada)

    2004-09-01

    The Cd and Zn total body burden of individual, up to 7-day-old aquatic organisms (Hyalella aztecabenthic amphipod) with an average volume of approximately 100 nL was determined simultaneously by using rhenium-cup (Re-cup) in-torch vaporization (ITV) sample introduction and an axially viewed inductively coupled plasma atomic emission spectrometry (ICP-AES) system. The direct elemental analysis capabilities of this system (i.e., no sample digestion) reduced sample preparation time, eliminated contamination concerns from the digestion reagent and, owing to its detection limits (e.g., in the low pg range for Cd and Zn), vit enabled simultaneous determinations of Cd and Zn in individual, neonate and young juvenile specimens barely visible to the unaided eye (e.g., nearly microscopic). As for calibration, liquid standards and the standard additions method were tested. Both methods gave comparable results, thus indicating that in this case liquid standards can be employed for calibration, and in the process making use of the standard additions method unnecessary. Overall, the ITV-ICP-AES approach by-passed the time-consuming acid digestions, eliminated the potential for contamination from the digestion reagents, improved considerably the speed of acquisition of analytical information and enabled simultaneous determinations of two elements using individual biological specimens. (orig.)

  16. Predicted burden of venous disease.

    Science.gov (United States)

    Onida, Sarah; Davies, Alun Huw

    2016-03-01

    Chronic venous disease is a common condition with clinical signs and symptoms ranging from spider veins, to varicose veins, to active venous ulceration. Both superficial and deep venous dysfunction may be implicated in the development of this disease. Socio-economic factors are shaping our population, with increasing age and body mass index resulting in significant pressure on healthcare systems worldwide. These risk factors also lead to an increased risk of developing superficial and/or deep venous insufficiency, increasing disease prevalence and morbidity. In this chapter, the authors review the current and future burden of chronic venous disease from an epidemiological, quality of life and economic perspective. PMID:26916773

  17. Power Functions Relating Excretion to Body Burden

    CERN Document Server

    Sanders, S M J

    2003-01-01

    Formulae necessary to relate the quantity of radionuclides excreted to that assimilated in exposures that are acute and those that are multiple or continuous are derived from power function relationships. Particular attention is given to providing equations having variables for which the bioassayer can easily derive numerical values. This paper presents this data.

  18. Petrological cannibalism: the chemical and textural consequences of incremental magma body growth

    Science.gov (United States)

    Cashman, Kathy; Blundy, Jon

    2013-09-01

    The textures of minerals in volcanic and plutonic rocks testify to a complexity of processes in their formation that is at odds with simple geochemical models of igneous differentiation. Zoning in plagioclase feldspar is a case in point. Very slow diffusion of the major components in plagioclase means that textural evidence for complex magmatic evolution is preserved, almost without modification. Consequently, plagioclase affords considerable insight into the processes by which magmas accumulate in the crust prior to their eventual eruption or solidification. Here, we use the example of the 1980-1986 eruptions of Mount St. Helens to explore the causes of textural complexity in plagioclase and associated trapped melt inclusions. Textures of individual crystals are consistent with multiple heating and cooling events; changes in total pressure ( P) or volatile pressure () are less easy to assess from textures alone. We show that by allying textural and chemical analyses of plagioclase and melt inclusions, including volatiles (H2O, CO2) and slow-diffusing trace elements (Sr, Ba), to published experimental studies of Mount St. Helens magmas, it is possible to disambiguate the roles of pressure and temperature to reconstruct magmatic evolutionary pathways through temperature-pressure-melt fraction ( T-- F) space. Our modeled crystals indicate that (1) crystallization starts at > 300 MPa, consistent with prior estimates from melt inclusion volatile contents, (2) crystal cores grow at = 200-280 MPa at F = 0.65-0.7, (3) crystals are transferred to = 100-130 MPa (often accompanied by 10-20 °C of heating), where they grow albitic rims of varying thicknesses, and (4) the last stage of crystallization occurs after minor heating at ~ 100 MPa to produce characteristic rim compositions of An50. We hypothesize that modeled decreases in excess of ~50 MPa most likely represent upward transport through the magmatic system. Small variations in modeled , in contrast, can be effected by

  19. Chemical treatment of Escherichia coli: 3. Selective extraction of a recombinant protein from cytoplasmic inclusion bodies in intact cells.

    Science.gov (United States)

    Falconer, R J; O'Neill, B K; Middelberg, A P

    1999-02-20

    In previous parts of this study we developed procedures for the high-efficiency chemical extraction of soluble and insoluble protein from intact Escherichia coli cells. Although high yields were obtained, extraction of recombinant protein directly from cytoplasmic inclusion bodies led to low product purity due to coextraction of soluble contaminants. In this work, a two-stage procedure for the selective extraction of recombinant protein at high efficiency and high purity is reported. In the first stage, inclusion-body stability is promoted by the addition of 15 mM 2-hydroxyethyldisulfide (2-HEDS), also known as oxidized beta-mercaptoethanol, to the permeabilization buffer (6 M urea + 3 mM ethylenediaminetetraacetate [EDTA]). 2-HEDS is an oxidizing agent believed to promote disulfide bond formation, rendering the inclusion body resistant to solubilization in 6 M urea. Contaminating proteins are separated from the inclusion-body fraction by centrifugation. In the second stage, disulfide bonds are readily eliminated by including reducing agent (20 mM dithiothreitol [DTT]) into the permeabilization buffer. Extraction using this selective two-stage process yielded an 81% (w/w) recovery of the recombinant protein Long-R3-IGF-I from inclusion bodies located in the cytoplasm of intact E. coli, at a purity of 46% (w/w). This was comparable to that achieved by conventional extraction (mechanical disruption followed by centrifugation and solubilization). A pilot-scale procedure was also demonstrated using a stirred reactor and diafiltration. This is the first reported study that achieves both high extraction efficiency and selectivity by the chemical treatment of cytoplasmic inclusion bodies in intact bacterial cells. PMID:9921154

  20. Burden of Mental Illness

    Science.gov (United States)

    ... 2008;14:757–784. Andreasen NC, Black DW. Introductory Textbook of Psychiatry (4th ed.). Washington, DC: American Psychiatric Publishing, Inc., 2006. Goeree R, Farahati F, Burke N, Blackhouse G, O’Reilly D, Pyne J, Tarride JE. The economic burden of schizophrenia in Canada in 2004. Curr ...

  1. Loan Burdens and Educational Outcomes.

    Science.gov (United States)

    Monks, James

    2001-01-01

    Studies the impact of the loan burden of seniors at 27 colleges and universities in 1998 on their plans to pursue graduate and professional degrees. Finds no adverse impact of loan burdens on student postgraduate degree plans. (PKP)

  2. Long-term monitoring of thorium inhaled by workers and assessment of thorium lung burden in China

    International Nuclear Information System (INIS)

    The long-term monitoring of thorium inhaled by workers and assessment of their thorium lung burden has been carried out in China since 1960. Various monitoring methods have been adopted, such as chemical analysis of thorium concentration in urine samples; assessing thorium lung burden by measurement of 212Pb etc. using a whole-body counter; measurement of exhaled thoron using a ZnS detector; or exhaled thoron decay products using an electrostatic collection system. Our experience over more than 20 years has shown that the last named measurement system is the best method for monitoring and assessing the lung burden of thorium (ThO2) inhaled by miners and workers. (author)

  3. Chemical composition and radical scavenging activity of melanin from Auricularia auricula fruiting bodies

    OpenAIRE

    Yu Zou; Yue Zhao; Wenzhong Hu

    2015-01-01

    Melanin extracted from Auricularia auricula fruiting bodies (AAFB) was examined by element analyzer, amino acid analyzer, inductively coupled plasma-optical emission spectrometry. Elemental composition analysis revealed that main component of AAFB melanin was pheomelanin. Amino acid analysis showed that 16 amino acids were found in AAFB melanin and total amino acid content was 321. 63 mg/g. There were 13 detectable metal elements in AAFB melanin, which was rich in Ca, Fe, Cu and Zn. In additi...

  4. Relationships among chemical compositions of 9-10-11th ribs, carcass and empty body of young Nellore bulls

    Directory of Open Access Journals (Sweden)

    Luiz Henrique Olivera Silva

    2013-12-01

    Full Text Available The direct determination of carcass and empty body composition as experimental routine, despite being the most accurate method, is time consuming, laborious and expensive. Therefore, indirect methods have been developed to estimate on quick, simple, economical and reliable ways for the compositions of carcass and empty body of beef cattle. This study aimed to obtain the correlations among the compositions of 9-10-11th ribs, carcass and empty body for protein, fat, ashes and water contents, expressed in percentage and kilograms, in young Nellore bulls. Sixty-seven non-castrated Nellore bulls were randomly selected for confining period in two consecutive years (2008 and 2009 and were confined in individual pens for approximately 100 days, until they reached a subcutaneous fat thickness of 4 mm over the Longissimus muscle. They were slaughtered at an average age of 540 days and body weight of 398 kg. Chemical analysis of the 9-10-11th ribs, carcass and empty body were carried for protein, fat, ashes and water. The 9-10-11th ribs cut was obtained according to Hankins and Howe (1946. Carcass composition was obtained after grinding, homogenizing, sampling, analyzing and combining edible portions and bones. Empty body composition was obtained after grinding, homogenizing, sampling, analyzing, and combining blood, hide, head + feet, viscera, and carcass. The correlation coefficients were calculated between ribs and carcass, and between ribs and empty body for the contents expressed in percentage and kilograms. The correlations obtained between composition of 9-10-11th ribs and carcass were 0.68; 0.62; 0.05; and 0.79, respectively, for percentages of protein, fat, ashes and water. For the same tissues, expressed in kilograms, the correlations obtained were 0.66; 0.73; 0.49; and 0.79, respectively, for contents of protein, fat, ashes and water. For the relationships between composition of the 9-10-11th ribs and empty body, the correlation coefficients

  5. Salmonella burden in Lebanon.

    Science.gov (United States)

    Malaeb, M; Bizri, A R; Ghosn, N; Berry, A; Musharrafieh, U

    2016-06-01

    Salmonellosis is a disease that represents a major public health concern in both developing and developed countries. The aim of this article is to evaluate the public health burden of Salmonella illness in Lebanon. The current scope of the Salmonella infection problem was assessed in relation to disease incidence and distribution with respect to age, gender and district. Factors that provide a better understanding of the magnitude of the problem were explored and highlighted. Data reported to the Epidemiologic Surveillance Department at the Lebanese Ministry of Public Health between 2001 and 2013 was reviewed. Information obtained was compared to information reported regionally and globally. The estimated true incidence was derived using multipliers from the CDC and Jordan. A literature review of all published data from Lebanon about Salmonella susceptibility/resistance patterns and its serious clinical complications was conducted. The estimated incidence was 13·34 cases/100 000 individuals, most cases occurred in the 20-39 years age group with no significant gender variation. Poor and less developed districts of Lebanon had the highest number of cases and the peak incidence was in summer. Reflecting on the projected incidence derived from the use of multipliers indicates a major discrepancy between what is reported and what is estimated. We conclude that data about Salmonella infection in Lebanon and many Middle Eastern and developing countries lack crucial information and are not necessarily representative of the true incidence, prevalence and burden of illness. PMID:26743045

  6. Prediction of physical and chemical body compositions of purebred and crossbred Nellore cattle using the composition of a rib section.

    Science.gov (United States)

    Marcondes, M I; Tedeschi, L O; Valadares Filho, S C; Chizzotti, M L

    2012-04-01

    The goal of this research was to develop empirical equations to predict chemical and physical compositions of the carcass and the body using the composition of the 9th- to 11th-rib section (rib(9-11)) and other measurements. A database (n = 246) from 6 studies was developed and comprised 37 bulls (BU), 115 steers (STR), and 94 heifers (HF), of which 132 were Nellore (NEL), 76 were NEL × Angus crossbreds (NA), and 38 were NEL × Simmental crossbreds (NS). The right half carcass and the rib(9-11) from the left half carcass were analyzed for ether extract (EE), CP, and water. The remaining components were chemically analyzed to determine the composition of the body. A stepwise procedure was used to determine the variable inclusion in the regression models. The variables included were EE in the rib(9-11) (EER; %), CP in the rib(9-11) (CPR; %), water in the rib(9-11) (WR; %), visceral fat (VF; %; KPH and mesenteric fats), organs plus viscera (OV; %), carcass dressing percentage (CD; %), cold carcass weight (kg), and empty BW (EBW; kg). No sex or breed effects were found on EE and CP compositions of the carcass (C(EE) and C(CP), respectively; %); the equations were as follows: C(EE) = 4.31 + 0.31 × EER + 1.37 × VF [n = 241; R(2) = 0.83; mean square error (MSE) = 4.53] and C(CP) = 17.92 + 0.60 × CPR - 0.17 × CD (n = 238; R(2) = 0.50; MSE = 1.58). Breed affected water content in the carcass (C(W), %); the equations were as follows: C(W) = 48.74 + 0.28 × WR - 0.017 × EBW for NEL; C(W) = 46.69 + 0.32 × WR - 0.017 × EBW for NA; and C(W) = 38.06 + 0.48 × WR - 0.017 × EBW for NS (n = 243; R(2) = 0.67; MSE = 5.17). A sex effect was found on body chemical EE composition (BW(EE)); the equations were as follows: BW(EE) = 2.75 + 0.33 × EER + 1.80 × VF for BU; BW(EE) = 1.84 + 0.33 × EER + 1.91 × VF for STR; and BW(EE) = 4.77 + 0.33 × EER + 1.28 × VF for HF (n = 243; R(2) = 0.89; MSE = 3.88). No sex or breed effects were found on CP composition in the body (BW

  7. Chemical composition of water hyacinth (Eichhronia Crassipes) a comparison indication of heavy metal pollution in egyptian water bodies. Vol. 4

    International Nuclear Information System (INIS)

    Water hyacinth is tested as an indicator for pollution in egyptian fresh surface waters. Chemical composition of water hyacinth as affected area of collection (water bodies) was studied and the suitability of this plant as a biological indicator for water pollution is discussed. Water hyacinth samples were collected three times per year for two years (1991-1993). Sample sites include one location in the river nile (at Helwan area), one site in Ismaillia canal, (at Mostrod industrial area), and one site in Abo-Zabal drain (at Abo-Zabal city). The concentration of 19 major major and trace elements in plant samples were determined by prompt gamma-ray neutron activation analysis. Results indicated that plant parts as well as location have a significant effect on elements content. Water hyacinth roots showed high affinity for accumulation of trace elements. 5 tabs

  8. Chemical treatment of Escherichia coli. II. Direct extraction of recombinant protein from cytoplasmic inclusion bodies in intact cells.

    Science.gov (United States)

    Falconer, R J; O'Neill, B K; Middelberg, A P

    1998-02-20

    A method is presented for the direct extraction of the recombinant protein Long-R3-IGF-I from inclusion bodies located in the cytoplasm of intact Escherichia coli cells. Chemical treatment with 6M urea, 3 mM EDTA, and 20 mM dithiothreitol (DTT) at pH 9.0 proved an effective combination for extracting recombinant protein from intact cells. Comparable levels of Long-R3-IGF-I were recovered by direct extraction as achieved by in vitro dissolution following mechanical disruption. However, the purity of directly extracted recombinant protein was lower due to contamination by bacterial cell components. The kinetics of direct extraction are described using a first-order equation with the time constant of 3 min. Urea appears important for permeabilization of the cell and dissolution of the inclusion body. Conversely, EDTA is involved in permeabilization of the cell wall and DTT enhances protein release. pH proved to be important with lower levels of protein release achieved at low pH values (Long-R3-IGF-I release and caused an observable increase in viscosity. Advantages of the direct extraction method include its speed, simplicity, and efficiency at releasing product. PMID:10099214

  9. Remediation strategies for perched water bodies underlying the Idaho Chemical Processing Plant at the Idaho National Engineering Laboratory

    International Nuclear Information System (INIS)

    Analysis of water samples collected from perched water underlying the Idaho Chemical Processing Plant (ICPP) at the Idaho National Engineering Laboratory (INEL) indicates the presence of low levels of radionuclides. The perching layers are formed by dense basalts and/or sediment interbeds with sufficient clay to form an aquitard. The distribution of contaminants and depth to water levels observed in the perched water well monitoring network suggest the perched water occurs as discrete bodies of water, but these are not necessarily interconnected across a large area. Present data suggests that the perching occurs as discrete of pools,'' and the presence of contamination is a function of vertical contaminant transport from above. The remediation of this perched water will be dependent upon the types of contaminants, the hydrogeologic conditions, the physical setting, and the size of the perched water body. Remediation strategies under consideration include the use of wells for the extraction of contaminated water and the installation of horizontal wells. A preliminary conceptual model has been developed and is being refined as additional hydrogeologic and contaminant data are acquired. Contaminant transport hypotheses have been formulated, and tests of those hypotheses are planned to assist with the refinement of the conceptual model. The testing of transport hypotheses and development of the conceptual model will help provide the basis to evaluate the available options for remediation of the perched water and to select the most effective strategy(ies) for implementation

  10. THE EFFECT OF HIGH DIETARY FERMENTABLE CARBOHYDRATE CONTENT ON THE FATTENING PERFORMANCE AND CHEMICAL BODY COMPOSITION OF FATTENING PIGS

    Directory of Open Access Journals (Sweden)

    Cs. Szabó

    2007-06-01

    Full Text Available The aim of the present study was to evaluate the effect of dietary fermentable carbohydrates (FC = faecal digestible organic matter - faecal digestible crude protein- faecal digestible crude fat - starch - sugars on the body composition and meat quality of pigs. A total of seventy two Stamboek hybrid pigs were housed in groups of six per pen (two pens with gilts and two with barrows per treatment. Three diets were formulated with a low, medium and high FC content (63, 148, 233 g/kg in the grower diets (45-75 kg and 67, 152, 237 g/kg in the finisher diets (75-110 kg. Feed and water were offered ad libitum. At slaughter (110 kg LW lean meat percentage, meat quality and chemical body composition were determined. Our data indicated, that carcass grading was improved by dietary FC. Diet with the high level of fermentable carbohydrates decreased fatness of the carcass and the organ fraction. It can be concluded that the fattening performance (FI, ADG, FCR was not affected adversely by the high FC intake, but carcass quality in pigs could be improved. Feedstuffs high in fermentable carbohydrates can be valuable ingredients for pig diets, once their energy content has been properly estimated.

  11. Sharing the Preservation Burden

    International Nuclear Information System (INIS)

    Preserving digitally encoded information which is not just to be rendered, as a document, but which must processed, like data, is even harder than one might think, because understandability of the information which is encoded in the digital object(s) is what is required. Information about Nuclear Waste will include both documents as well as data. Moreover one must be able to understand the relationship between the many individual pieces of information. Furthermore the volume of information involved will require us to allow automated processing of such information. Preserving the ability to understand and process digitally encoded information over long periods of time is especially hard when so many things will change, including hardware, software, environment and the tacit and implicit knowledge that people have. Since we cannot predict these changes this cannot be just a one-off action; continued effort is required. However it seems reasonable to say that no organization, project or person can ever say for certain that their ability to provide this effort is going to last forever. What can be done? Can anything be guaranteed? Probably not guaranteed - but at least one can try to reduce the risk of losing the information. We argue that if no single organization, project or person can guarantee funding or effort (or even interest), then somehow we must share the 'preservation load', and this is more than a simple chain of preservation consisting of handing on the collection of bits from one holder to the next. Clearly the bits must be passed on (but may be transformed along the way), however something more is required - because of the need to maintain understandability, not just access. This paper describes the tools, techniques and infrastructure components which the CASPAR project is producing to help in sharing the preservation burden. In summary: CASPAR is attempting to use OAIS concepts rigorously and to the fullest extent possible, supplementing these where

  12. Effective dose and time-integrated effective dose to humans from internal contamination of 134Cs and 137Cs: Results from a compilation of a Swedish national database of internal body burden of radiocaesium in various populations between 1964 and 2002

    International Nuclear Information System (INIS)

    A compilation of data on the whole-body burden of 134Cs, 137Cs and 40K in various Swedish populations between 1964 and 2002 has been made. The compilation was carried out in co-operation with the Department of Radiation Physics in Malmoe, the Swedish Radiation Protection Authority (SSI), the Swedish Defence Research Agency Department (FOI) and the Department of Radiation Physics, Goeteborg University. Individual body burden values have been inserted into a calculation spread sheet, with data on body weight, gender, age, occupation (if available) and place of residence. The database enables a study of the time-pattern and geographical dependence of radiocaesium transfer from ground deposition to man, and the associated absorbed dose. The Swedish government has assigned SSI the responsibility for obtaining and assuring one of Sweden's national environmental quality objectives, A Safe Radiation Environment. A natural consequence of this responsibility is that a means for quantifying progress towards the objective is necessary. The data compilation discussed here is one important component in the national environmental monitoring programme that is currently (2002) being developed at SSI. The new program for monitoring environmental radiation has the goal of following geographical and ecological differences in the radiological effects to both mankind and the environment, and assessing relevant doses and risks. During the period between 1964 and 2002, fallout of radiocaesium from nuclear weapons tests (only 137Cs) and from the Chernobyl accident in 1986 (both 134Cs and 137Cs) have occurred in Sweden. The ground deposition of the radiocaesium has gradually been transferred through different ecological pathways to man. From the database it can be deduced that large regional variations in the body burden of radiocaesium in man have occurred through this period. Three populations exhibit considerably higher body content levels than others; (i) reindeer herders in central

  13. Natural background levels and threshold values of chemical species in three large-scale groundwater bodies in Northern Italy

    Energy Technology Data Exchange (ETDEWEB)

    Molinari, Antonio, E-mail: ant.molinari2002@libero.it [Politecnico di Milano, Dipartimento di Ingegneria Idraulica, Ambientale, Infrastrutture Viarie e Rilevamento, Piazza L. Da Vinci, 32-20133 Milano (Italy); Guadagnini, Laura [Politecnico di Milano, Dipartimento di Ingegneria Idraulica, Ambientale, Infrastrutture Viarie e Rilevamento, Piazza L. Da Vinci, 32-20133 Milano (Italy); Marcaccio, Marco [ARPA Emilia-Romagna, Direzione Tecnica, Largo Caduti del Lavoro, 6-40122 Bologna (Italy); Guadagnini, Alberto [Politecnico di Milano, Dipartimento di Ingegneria Idraulica, Ambientale, Infrastrutture Viarie e Rilevamento, Piazza L. Da Vinci, 32-20133 Milano (Italy)

    2012-05-15

    We analyze natural background levels (NBLs) and threshold values (TVs) of spatially distributed chemical species (NH{sub 4}, B and As) which may be a potential pressure and concern in three large scale alluvial and fluvio-deltaic aquifers at different depths of the Apennines and Po river plains in Emilia-Romagna, Northern Italy. Our results are based on statistical methodologies designed to separate the natural and anthropogenic contributions in monitored concentrations by modeling the empirical distribution of the detected concentration with a mixture of probability density functions. Available chemical observations are taken over a 20 years period and are associated with different depths and cover planar investigation scales of the order of hundreds of kilometers. High concentration values detected for NH{sub 4} and B appear to be related to high natural background levels. Due to interaction with the host rock in different geochemical environments we observed that concentration vary in time and space (including in depth) consistently with the hydrogeochemical features and the occurrence of natural attenuation mechanisms in the analyzed reservoirs. Conversely, estimated As NBLs are not consistent with the conceptual model of the hydrogeochemical behavior of the systems analyzed and experimental evidences of As content in aquifer cores. This is due to the inability of these techniques to incorporate the complex dynamics of the processes associated with the specific hydrogeochemical setting. Statistical analyses performed upon aggregating the concentration data according to different time observation windows allow identifying temporal dynamics of NBLs and TVs of target compounds within the observation time frame. Our results highlight the benefit of a dynamic monitoring process and analysis of well demarcated groundwater bodies to update the associated NBLs as a function of the temporal dependence of natural processes occurring in the subsurface. Monitoring

  14. Physical Measurements and Clinical Findings of Persons with Radium Burdens

    International Nuclear Information System (INIS)

    Results of physical measurements and some clinical findings of persons with radium burdens are reported and discussed. Ten workers of the dial painting industry, two chemists, who have been working for between 10 and 20 yr in the radium- industry, one technician, who has been- working for over 20 yr with high-emanation radium preparations and one person with high radium intake of rather unknown history were measured in a whole-body counter for evaluation of the body burdens of radium-226 and radium-228+ actinium-228. In some cases the radon concentration of expired air was also measured. For four of the measured persons the radium-226 burden is of the order of the maximum permissible amount (MPA : 10-7 c) or more. In one case the burden amounts to more than three times the MPA, (3.4 x 10-7 c), in another case to more than 100 times the MPA (160 x 10-7 c). In one case the radium-228 + actinium-228 burden exceeds the MPA (6 x 10-8 c in bone). The measured radon concentrations in the expired air were used to calculate the excretion rate of radon. The average was 67%. Clinical findings with some of the measured persons are related to the measured body burdens. The patient with the high body burden of 160 x 10-7 c radium-226 shows heavy bone changes leading to spontaneous bone fractures. The blood picture shows a decrease in the number of erythrocytes and a low haemoglobin content but puncture of the sternum indicates normal haematopoiesis. It seems that the low number of erythrocytes is caused by chronic nephropathia, the reason for which might be an additional intake of uranium because.uranium was found in the urine by gamma spectroscopy. The results are discussed with respect to the MPA of radium-226 recommended by the International Commission on Radiological Protection. (author)

  15. Caregiver burden in dependent elderly.

    Directory of Open Access Journals (Sweden)

    José Mauricio Ocampo

    2009-11-01

    Full Text Available Objectives: To determine the frequency and the associated factors with the presence of care burden imposed by dependent elderly of Buenaventura, Valle; Colombia. Design: A pilot cross-sectional study. Patients and methods: Between March and May of 2006, data were collected on 35 over 60 years old patients who live in the community of Buenaventura, with a score in the Barthel index Results: The mean age and the standard deviation of the patient group was 78.9±10 years. There was a larger proportion of women (68.5%. In the care givers, the regular age and the standard deviation was 49.4±18.8 years, where 91% were women. It was found that for 54.2% of the caregivers there was no burden at all, 40% of them had a minimum burden and the others a greater burden. Bivariate analysis between the care giver’s burden and the number of chronic disease, the score on the minimental test, elderly depression and the family APGAR, resulted in statistic association (p Conclusions: There is an association between aged people, dependent in basic common day activities related with physical aspects, and care giver’s burden. Being the caregivers mostly family members, further studies must be focused on identifying and realizing interventions to prevent or limit the decrease of declining mental health and loss of life quality and the consequent increase of the care giver’s burden.

  16. Natural background levels and threshold values of chemical species in three large-scale groundwater bodies in Northern Italy.

    Science.gov (United States)

    Molinari, Antonio; Guadagnini, Laura; Marcaccio, Marco; Guadagnini, Alberto

    2012-05-15

    We analyze natural background levels (NBLs) and threshold values (TVs) of spatially distributed chemical species (NH(4), B and As) which may be a potential pressure and concern in three large scale alluvial and fluvio-deltaic aquifers at different depths of the Apennines and Po river plains in Emilia-Romagna, Northern Italy. Our results are based on statistical methodologies designed to separate the natural and anthropogenic contributions in monitored concentrations by modeling the empirical distribution of the detected concentration with a mixture of probability density functions. Available chemical observations are taken over a 20 years period and are associated with different depths and cover planar investigation scales of the order of hundreds of kilometers. High concentration values detected for NH(4) and B appear to be related to high natural background levels. Due to interaction with the host rock in different geochemical environments we observed that concentration vary in time and space (including in depth) consistently with the hydrogeochemical features and the occurrence of natural attenuation mechanisms in the analyzed reservoirs. Conversely, estimated As NBLs are not consistent with the conceptual model of the hydrogeochemical behavior of the systems analyzed and experimental evidences of As content in aquifer cores. This is due to the inability of these techniques to incorporate the complex dynamics of the processes associated with the specific hydrogeochemical setting. Statistical analyses performed upon aggregating the concentration data according to different time observation windows allow identifying temporal dynamics of NBLs and TVs of target compounds within the observation time frame. Our results highlight the benefit of a dynamic monitoring process and analysis of well demarcated groundwater bodies to update the associated NBLs as a function of the temporal dependence of natural processes occurring in the subsurface. Monitoring protocols could

  17. Layered Model for Radiation-Induced Chemical Evolution of Icy Surface Composition on Kuiper Belt and Oort Cloud Bodies

    Science.gov (United States)

    Cooper, John F.; Hill, Matthew E.; Richardson, John D.; Sturner, Steven J.

    2010-01-01

    The diversity of albedos and surface colors on observed Kuiper Belt and Inner Oort Cloud objects remains to be explained in terms of competition between primordial intrinsic versus exogenic drivers of surface and near-surface evolution. Earlier models have attempted without success to attribute this diversity to the relations between surface radiolysis from cosmic ray irradiation and gardening by meteoritic impacts. A more flexible approach considers the different depth-dependent radiation profiles produced by low-energy plasma, suprathermal, and maximally penetrating charged particles of the heliospheric and local interstellar radiation environments. Generally red objects of the dynamically cold (low inclination, circular orbit) Classical Kuiper Belt might be accounted for from erosive effects of plasma ions and reddening effects of high energy cosmic ray ions, while suprathermal keV-MeV ions could alternatively produce more color neutral surfaces. The deepest layer of more pristine ice can be brought to the surface from meter to kilometer depths by larger impact events and potentially by cryovolcanic activity. The bright surfaces of some larger objects, e.g. Eris, suggest ongoing resurfacing activity. Interactions of surface irradiation, resultant chemical oxidation, and near-surface cryogenic fluid reservoirs have been proposed to account for Enceladus cryovolcanism and may have further applications to other icy irradiated bodies. The diversity of causative processes must be understood to account for observationally apparent diversities of the object surfaces.

  18. HIV / AIDS: An Unequal Burden

    Science.gov (United States)

    Skip Navigation Bar Home Current Issue Past Issues HIV / AIDS HIV / AIDS: An Unequal Burden Past Issues / Summer 2009 ... high-risk category, emphasizes Dr. Cargill. Photo: iStock HIV and Pregnancy Are there ways to help HIV- ...

  19. HIV / AIDS: An Unequal Burden

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues HIV / AIDS HIV / AIDS: An Unequal Burden Past Issues / Summer 2009 Table ... Victoria Cargill talks to students about HIV and AIDS at the opening of a National Library of ...

  20. Adjustment of a direct method for the determination of man body burden in Pu-239 on by X-ray detection of U-235; Mise au point d'une methode directe de determination de la charge corporelle en plutonium 239 chez l'homme par detection X de l'uranium 235

    Energy Technology Data Exchange (ETDEWEB)

    Boulay, P. [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

    1968-04-01

    The use of Pu-239 on a larger scale sets a problem about the contamination measurement by aerosol at lung level. A method of direct measurement of Pu-239 lung burden is possible, thanks to the use of a large area window proportional counter. A counter of such pattern, has been especially carried out for this purpose. The adjustment of the apparatus allows an adequate sensibility to detect a contamination at the maximum permissible body burden level. Besides, a method for individual 'internal calibration', with a plutonium mock: the protactinium-233, is reported. (author) [French] L'utilisation a une echelle de plus en plus large du plutonium-239 pose un probleme de la mesure de la contamination par aerosol au niveau du poumon. Une methode de mesure directe de la charge pulmonaire en plutonium-239 est possible grace a l'utilisation d'un compteur proportionnel a fenetre de grande surface. Un compteur de ce type a specialement ete realise dans ce but. La mise au point de l'appareillage permet une sensibilite suffisante pour deceler une contamination au niveau de la Q.M.A (quantite maximale admissible). D'autre part, une methode 'd'etalonnage interne' de l'individu a l'aide d'un simulateur de plutonium, le protactinium-233, est decrite. (auteur)

  1. CHEMICALS

    CERN Multimedia

    Medical Service

    2002-01-01

    It is reminded that all persons who use chemicals must inform CERN's Chemistry Service (TIS-GS-GC) and the CERN Medical Service (TIS-ME). Information concerning their toxicity or other hazards as well as the necessary individual and collective protection measures will be provided by these two services. Users must be in possession of a material safety data sheet (MSDS) for each chemical used. These can be obtained by one of several means : the manufacturer of the chemical (legally obliged to supply an MSDS for each chemical delivered) ; CERN's Chemistry Service of the General Safety Group of TIS ; for chemicals and gases available in the CERN Stores the MSDS has been made available via EDH either in pdf format or else via a link to the supplier's web site. Training courses in chemical safety are available for registration via HR-TD. CERN Medical Service : TIS-ME :73186 or service.medical@cern.ch Chemistry Service : TIS-GS-GC : 78546

  2. Procedure used to estimate the lung burden of uranium

    International Nuclear Information System (INIS)

    Two problems arise in determining the lung or body burden of an individual. The first is to determine the type of phantom which will satisfactorily simulate the subject and the second is to estimate the response of the measurement system to the subject if he were not contaminated in order to generate a base spectrum to which the actual subject spectrum is compared

  3. Caregiver Burden in Chronic Diseases

    Directory of Open Access Journals (Sweden)

    Murat Ilhan Atagun

    2011-09-01

    Full Text Available Duration of human life has been substantially increased in the last fifty years. Survivals of diseases have been prolonged through the advances in medicine. Together with these gratifying consequences, there appeared novel difficulties to cope with. Furthermore developments including globalization, industrialization and transition from rural to urban life occurred during the last century; so family units became smaller and numbers of members on employment in family units increased. As a result numbers of family members to undertake the responsibility of care decreased. As a concept, caregiver burden expresses physical, psychosocial and financial reactions during the course of care providing. Distinct factors including structures of social, cultural and family units and health care systems may affect conditions of care. Caregiver’s age, gender, ethnicity, education, relationship with the patient, attitude towards providing care, financial situation, coping abilities, her own health, beliefs, social support and cultural pattern are the personal factors that are related to perception of caregiver burden. Burden of care giving is geared to differential aspects of care needs. For instance care needs of physically disabled and medical care requiring patients with spinal cord injuries may differ from care needs of chronic psychiatric disorders, demented patients in advanced age of their lives or cancer patients in terminal periods. Strain due to care giving may differ as a result of properties of care demands. It is aimed to review the burden of caregivers in different medical and psychiatric care requiring conditions and to introduce differential aspects of caregiver burden in these different conditions.

  4. Burden of Proof in Bioethics.

    Science.gov (United States)

    Koplin, Julian J; Selgelid, Michael J

    2015-11-01

    A common strategy in bioethics is to posit a prima facie case in favour of one policy, and to then claim that the burden of proof (that this policy should be rejected) falls on those with opposing views. If the burden of proof is not met, it is claimed, then the policy in question should be accepted. This article illustrates, and critically evaluates, examples of this strategy in debates about the sale of organs by living donors, human enhancement, and the precautionary principle. We highlight general problems with this style of argument, and particular problems with its use in specific cases. We conclude that the burden ultimately falls on decision-makers (i.e. policy-makers) to choose the policy supported by the best reasons. PMID:26481200

  5. COMPARATIVE STUDY OF THE BODY WEIGHT CHARACTERISTICS AND EFFECT OF DRYING ON CHEMICAL COMPOSITION OF THREE NILE FISH SPECIES (Oreochromis Niloticus, Labeo Niloticus AND Clarias Spp.)

    OpenAIRE

    Hassan M. YAGOUB ADAM; Ahmed Mohamed MUSA AHMED; Abdelwahab M ADAM IBRAHIM; Fathi MIRGHANI YOUSIF

    2015-01-01

    This study was carried out to compare the body weights of three different Nile fish species (Oreochromis niloticus, Labeo niloticus and Clarias spp.), and the impact of direct sun drying on their chemical composition.36 samples were collected (12 samples/ species). Averages of total length, standard length (cm) and gross body weight (gm) were determined and the findings were as follows: 36.5, 29.75 and 930 for Oreochromis niloticus, 49, 39.5 and 1210 for Labeo niloticus and 49, 45 and 977.5 f...

  6. Joint audits - benefit or burden?

    DEFF Research Database (Denmark)

    Holm, Claus; Thinggaard, Frank

    audits to be a net burden. Furthermore, based on DeAngelo's (1981) initial audit pricing model and legislators' claim that joint audits are an unnecessary economic burden to the companies we predict and find discounts (of around 25%) in audit fees in companies that change to single audits. The primary...... joint audit regime to a single auditor/voluntary joint audit regime. The dataset used in this paper has been collected for the full population of non-financial Danish companies listed on the Copenhagen Stock Exchange (CSE) in the years 2004 and 2005. We find that a majority of firms perceive joint...

  7. Chemicals identified in human biological media: a data base. Third annual report, October 1981

    Energy Technology Data Exchange (ETDEWEB)

    Cone, M.V.; Baldauf, M.F.; Martin, F.M. (comps.)

    1981-12-01

    Data from almost 1600 of the 3800 body-burden documents collected to date have been entered in the data base as of October 1981. The emphasis on including recent literature and significant research documents has resulted in a chronological mix of articles from 1974 to the present. When body-burden articles are identified, data are extracted and entered in the data base by chemical and tissue/body fluid. Each data entry comprises a single record (or line entry) and is assigned a record number. If a particular document deals with more than one chemical and/or tissue, there will be multiple records for that document. For example, a study of 5 chemicals in each of 3 tissues has 15 different records (or 15 line entries) in the data base with 15 record numbers. Record numbers are assigned consecutively throughout the entire data base and appear in the upper left corner of the first column for each record.

  8. Using PBPK guided “Body-on-a-Chip” Systems to Predict Mammalian Response to Drug and Chemical Exposure

    OpenAIRE

    Sung, Jong Hwan; Srinivasan, Balaji; Esch, Mandy Brigitte; McLamb, William T.; Bernabini, Catia; Shuler, Michael L.; Hickman, James J.

    2014-01-01

    The continued development of in vitro systems that accurately emulate human response to drugs or chemical agents will impact drug development, our understanding of chemical toxicity, and enhance our ability to respond to threats from chemical or biological agents. A promising technology is to build microscale replicas of humans that capture essential elements of physiology, pharmacology and/or toxicology (microphysiological systems). Here, we review progress on systems for microscale models o...

  9. The Physical Burdens of Secrecy

    Science.gov (United States)

    Slepian, Michael L.; Masicampo, E. J.; Toosi, Negin R.; Ambady, Nalini

    2012-01-01

    The present work examined whether secrets are experienced as physical burdens, thereby influencing perception and action. Four studies examined the behavior of people who harbored important secrets, such as secrets concerning infidelity and sexual orientation. People who recalled, were preoccupied with, or suppressed an important secret estimated…

  10. Genomic scan for quantitative trait loci of chemical and physical body composition and deposition on pig chromosome X including the pseudoautosomal region of males

    Directory of Open Access Journals (Sweden)

    Kalm Ernst

    2009-03-01

    Full Text Available Abstract A QTL analysis of pig chromosome X (SSCX was carried out using an approach that accurately takes into account the specific features of sex chromosomes i.e. their heterogeneity, the presence of a pseudoautosomal region and the dosage compensation phenomenon. A three-generation full-sib population of 386 animals was created by crossing Pietrain sires with a crossbred dam line. Phenotypic data on 72 traits were recorded for at least 292 and up to 315 F2 animals including chemical body composition measured on live animals at five target weights ranging from 30 to 140 kg, daily gain and feed intake measured throughout growth, and carcass characteristics obtained at slaughter weight (140 kg. Several significant and suggestive QTL were detected on pig chromosome X: (1 in the pseudoautosomal region of SSCX, a QTL for entire loin weight, which showed paternal imprinting, (2 closely linked to marker SW2456, a suggestive QTL for feed intake at which Pietrain alleles were found to be associated with higher feed intake, which is unexpected for a breed known for its low feed intake capacity, (3 at the telomeric end of the q arm of SSCX, QTL for jowl weight and lipid accretion and (4 suggestive QTL for chemical body composition at 30 kg. These results indicate that SSCX is important for physical and chemical body composition and accretion as well as feed intake regulation.

  11. Determining High-Quality Critical Body Residues for Multiple Species and Chemicals by Applying Improved Experimental Design and Data Interpretation Concepts

    DEFF Research Database (Denmark)

    van der Heijden, Stephan A.; Hermens, Joop L. M.; Sinnige, Theo L.;

    2015-01-01

    , and by a factor of 2.6 between the three species but for individual chemicals. Accounting for the chemicals internal distribution to different partitioning domains and relating effects to estimated concentrations in the target compartment (i.e., membrane lipids) was expected to but did not decrease the overall......Ecotoxicological effect data are generally expressed as effective concentrations in the external exposure medium and do thus not account for differences in chemical uptake, bioavailability, and metabolism, which can introduce substantial data variation. The Critical Body Residue (CBR) concept...... provides clear advantages, because it links effects directly to the internal exposure. Using CBRs instead of external concentrations should therefore reduce variability. For compounds that act via narcosis even a constant CBR has been proposed. Despite the expected uniformity, CBR values...

  12. The global burden of injuries.

    Science.gov (United States)

    Krug, E G; Sharma, G K; Lozano, R

    2000-04-01

    The traditional view of injuries as "accidents", or random events, has resulted in the historical neglect of this area of public health. However, the most recent estimates show that injuries are among the leading causes of death and disability in the world. They affect all populations, regardless of age, sex, income, or geographic region. In 1998, about 5.8 million people (97.9 per 100,000 population) died of injuries worldwide, and injuries caused 16% of the global burden of disease. Road traffic injuries are the 10th leading cause of death and the 9th leading cause of the burden of disease; self-inflicted injuries, falls, and interpersonal violence follow closely. Injuries affect mostly young people, often causing long-term disability. Decreasing the burden of injuries is among the main challenges for public health in the next century--injuries are preventable, and many effective strategies are available. Public health officials must gain a better understanding of the magnitude and characteristics of the problem, contribute to the development and evaluation of injury prevention programs, and develop the best possible prehospital and hospital care and rehabilitation for injured persons. PMID:10754963

  13. Investigating the burden of parasitic zoonotic diseases

    OpenAIRE

    Torgerson, P.R.; Craig, P

    2010-01-01

    Although the global burden for most parasitic zoonoses is not yet known, it is clear that collectively parasitic zoonoses have a similar human disease burden to any one of the big three human infectious diseases: malaria, tuberculosis or HIV. In addition many also have a substantial animal health and economic burden.

  14. The Assessment of Radioactive Body Burdens of the Alkaline Earths

    International Nuclear Information System (INIS)

    The difficulties in obtaining data on the metabolism of bone-seeking radioactive isotopes in man are widely appreciated, especially on the distribution of the isotope between different bones and the microscopic distribution within the same bone. If a full understanding of the metabolism in man is to be obtained, there is at present no alternative but to resort to the use of experimental animals. The calcium and strontium metabolism of the rabbit, which is the smallest animal to have similar skeletal structure to that of human bone, has been studied. The research was planned to include as many parameters as possible. These included specific activity measurements of plasma, urine and faeces, total retention in the skeleton as well as individual bones and in some cases soft tissue. In addition the microscopic distribution of the isotope was studied by quantitative autoradiographic techniques at different time intervals. The results have been considered in the light of various models proposed for the retention of bone-seeking isotopes in mammals and the limitations of each of these models have been assessed. Measurements have been made over sufficiently long time intervals compared with the life-span of the rabbit to enable predictions to be made about the long-term behaviour in man. The results indicate that none of the existing models is completely satisfactory but that a modification of the power function is the most useful. The importance of exchange, as well as resorption, for the removal of radioactive isotopes from the skeleton is well illustrated by the quantitative autoradiographic measurements. (author)

  15. BARIUM IN TEETH AS INDICATOR OF BODY BURDEN

    Science.gov (United States)

    A study was conducted to determine the biological availability of naturally occurring barium in a municipal drinking water by the analysis of barium in deciduous teeth of children. The grade school children of two Illinois towns were chosen for the study. The towns were chosen ba...

  16. The Nature of the Chemical Bond in Linear Three-Body Systems: From I3– to Mixed Chalcogen/Halogen and Trichalcogen Moieties

    Directory of Open Access Journals (Sweden)

    M. Carla Aragoni

    2007-01-01

    Full Text Available The 3 centre-4 electrons (3c-4e and the donor/acceptor or charge-transfer models for the description of the chemical bond in linear three-body systems, such as I3– and related electron-rich (22 shell electrons systems, are comparatively discussed on the grounds of structural data from a search of the Cambridge Structural Database (CSD. Both models account for a total bond order of 1 in these systems, and while the former fits better symmetric systems, the latter describes better strongly asymmetric situations. The 3c-4e MO scheme shows that any linear system formed by three aligned closed-shell species (24 shell electrons overall has reason to exist provided that two electrons are removed from it to afford a 22 shell electrons three-body system: all combinations of three closed-shell halides and/or chalcogenides are considered here. A survey of the literature shows that most of these three-body systems exist. With some exceptions, their structural features vary continuously from the symmetric situation showing two equal bonds to very asymmetric situations in which one bond approaches to the value corresponding to a single bond and the second one to the sum of the van der Waals radii of the involved atoms. This indicates that the potential energy surface of these three-body systems is fairly flat, and that the chemical surrounding of the chalcogen/halogen atoms can play an important role in freezing different structural situations; this is well documented for the I3– anion. The existence of correlations between the two bond distances and more importantly the linearity observed for all these systems, independently on the degree of their asymmetry, support the state of hypervalency of the central atom.

  17. Genomic scan for quantitative trait loci of chemical and physical body composition and deposition on pig chromosome X including the pseudoautosomal region of males

    OpenAIRE

    Kalm Ernst; Doeschl-Wilson Andrea; Pérez-Enciso Miguel; Simm Geoff; Duthie Carol-Anne; Knap Pieter W; Roehe Rainer

    2009-01-01

    Abstract A QTL analysis of pig chromosome X (SSCX) was carried out using an approach that accurately takes into account the specific features of sex chromosomes i.e. their heterogeneity, the presence of a pseudoautosomal region and the dosage compensation phenomenon. A three-generation full-sib population of 386 animals was created by crossing Pietrain sires with a crossbred dam line. Phenotypic data on 72 traits were recorded for at least 292 and up to 315 F2 animals including chemical body ...

  18. Iron- and 4-hydroxy-2-alkylquinoline-containing periplasmic inclusion bodies of Pseudomonas aeruginosa: A chemical analysis

    Science.gov (United States)

    Royt, P.W.; Honeychuck, R.V.; Pant, R.R.; Rogers, M.L.; Asher, L.V.; Lloyd, J.R.; Carlos, W.E.; Belkin, H.E.; Patwardhan, S.

    2007-01-01

    Dark aggregated particles were seen on pellets of iron-rich, mid-logarithmic phase Pseudomonas aeruginosa. Transmission electron microscopy of these cells showed inclusion bodies in periplasmic vacuoles. Aggregated particles isolated from the spent medium of these cells contained iron as indicated by atomic absorption spectroscopy and by electron paramagnetic resonance spectroscopy that revealed Fe3+. Scanning electron microscopy/energy dispersive X-ray analysis of whole cells revealed the presence of iron-containing particles beneath the surface of the cell, indicating that the isolated aggregates were the intracellular inclusion bodies. Collectively, mass spectroscopy and nuclear magnetic resonance spectroscopy of the isolated inclusion bodies revealed the presence of 3,4-dihydroxy-2-heptylquinoline which is the Pseudomonas quinolone signaling compound (PQS) and an iron chelator; 4-hydroxy-2-heptylquinoline (pseudan VII), which is an iron chelator, antibacterial compound and precursor of PQS; 4-hydroxy-2-nonylquinoline (pseudan IX) which is an iron chelator and antibacterial compound; 4-hydroxy-2-methylquinoline (pseudan I), and 4-hydroxy-2-nonylquinoline N-oxide. ?? 2006 Elsevier Inc. All rights reserved.

  19. Stratospheric carbonyl sulfide (OCS) burden

    Science.gov (United States)

    Kloss, Corinna; Walker, Kaley A.; Deshler, Terry; von Hobe, Marc

    2015-04-01

    An estimation of the global stratospheric burden of carbonyl sulfide (OCS) calculated using satellite based measurements from the Atmospheric Chemistry Experiment - Fourier Transform Spectrometer (ACE-FTS) will be presented. OCS is the most abundant sulfur containing gas in the atmosphere in the absence of volcanic eruptions. With a long lifetime of 2-6 years it reaches the stratosphere where it is photolyzed and the sulfur oxidized and condensed to aerosols, contributing to the stratospheric aerosol layer. The aerosol layer is the one factor of the middle-atmosphere with a direct impact on the Earth's climate by scattering incoming solar radiation back to space. Therefore it is crucial to understand and estimate the different processes and abundances of the species contributing to the aerosol layer. However, the exact amount of OCS in the stratosphere has not been quantified yet. A study on the OCS mixing ratio distribution based on ACE-FTS data has already been made by Barkley et al. (2008), also giving an estimation for the total atmospheric OCS mass. ACE-FTS is an infrared solar occultation spectrometer providing high- resolution profile observations since 2004. In the scope of this work the focus lies on the stratospheric OCS burden, calculated by integrating the ACE profiles. A global overview on the stratospheric OCS amount in the past and present based on the ACE data as well as a look at regional and seasonal variability will be given. Furthermore, the results of this work will be useful for further studies on OCS fluxes and lifetimes, and in quantifying the contribution of OCS to the global stratospheric sulfur burden. Barkley et al., 2008, Geophys. Res. Lett., 35, L14810.

  20. 40 CFR 22.24 - Burden of presentation; burden of persuasion; preponderance of the evidence standard.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Burden of presentation; burden of... ENVIRONMENTAL PROTECTION AGENCY GENERAL CONSOLIDATED RULES OF PRACTICE GOVERNING THE ADMINISTRATIVE ASSESSMENT... Burden of presentation; burden of persuasion; preponderance of the evidence standard. (a) The...

  1. Burden of pediatric hepatitis C

    OpenAIRE

    El-Shabrawi, Mortada Hassan; Kamal, Naglaa Mohamed

    2013-01-01

    Hepatitis C virus (HCV) is a major health burden infecting 170-210 million people worldwide. Additional 3-4 millions are newly-infected annually. Prevalence of pediatric infection varies from 0.05%-0.36% in the United States and Europe; up to 1.8%-5.8% in some developing countries. The highest prevalence occurs in Egypt, sub-Saharan Africa, Amazon basin and Mongolia. HCV has been present in some populations for several centuries, notably genotypes 1 and 2 in West Africa. Parenteral anti-schis...

  2. Indigenous identity: burden or liberation?

    DEFF Research Database (Denmark)

    Steur, Luisa Johanna

    2010-01-01

    With the rise of ‘adivasi’ (‘indigenous’ or ‘tribal’) movements in different parts of South Asia in the past two decades, the question of how to understand ‘adivasi identity’ has become hotly debated: is it a burden, inviting distorted stereotypical depictions of subaltern people, or is it a prom...... promising means toward their liberation? As Luisa Steur’s fieldwork on the Adivasi Gothra Maha Sabha (AGMS), the main adivasi movement in Kerala, demonstrates, answers to this question can be of immediate political consequence....

  3. The increasing burden of depression

    Directory of Open Access Journals (Sweden)

    Lépine J-P

    2011-05-01

    Full Text Available Jean-Pierre Lépine1, Mike Briley21Hôpital Lariboisière Fernand Widal, Assistance Publique Hôpitaux de Paris Unité INSERM 705 CNRS UMR 8206, Université Paris Diderot, Paris, France; 2NeuroBiz Consulting and Communication, Castres, FranceAbstract: Recent epidemiological surveys conducted in general populations have found that the lifetime prevalence of depression is in the range of 10% to 15%. Mood disorders, as defined by the World Mental Health and the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, have a 12-month prevalence which varies from 3% in Japan to over 9% in the US. A recent American survey found the prevalence of current depression to be 9% and the rate of current major depression to be 3.4%. All studies of depressive disorders have stressed the importance of the mortality and morbidity associated with depression. The mortality risk for suicide in depressed patients is more than 20-fold greater than in the general population. Recent studies have also shown the importance of depression as a risk factor for cardiovascular death. The risk of cardiac mortality after an initial myocardial infarction is greater in patients with depression and related to the severity of the depressive episode. Greater severity of depressive symptoms has been found to be associated with significantly higher risk of all-cause mortality including cardiovascular death and stroke. In addition to mortality, functional impairment and disability associated with depression have been consistently reported. Depression increases the risk of decreased workplace productivity and absenteeism resulting in lowered income or unemployment. Absenteeism and presenteeism (being physically present at work but functioning suboptimally have been estimated to result in a loss of $36.6 billion per year in the US. Worldwide projections by the World Health Organization for the year 2030 identify unipolar major depression as the leading cause of disease burden

  4. COMPARATIVE STUDY OF THE BODY WEIGHT CHARACTERISTICS AND EFFECT OF DRYING ON CHEMICAL COMPOSITION OF THREE NILE FISH SPECIES (Oreochromis Niloticus, Labeo Niloticus AND Clarias Spp.

    Directory of Open Access Journals (Sweden)

    Hassan M. YAGOUB ADAM

    2015-11-01

    Full Text Available This study was carried out to compare the body weights of three different Nile fish species (Oreochromis niloticus, Labeo niloticus and Clarias spp., and the impact of direct sun drying on their chemical composition.36 samples were collected (12 samples/ species. Averages of total length, standard length (cm and gross body weight (gm were determined and the findings were as follows: 36.5, 29.75 and 930 for Oreochromis niloticus, 49, 39.5 and 1210 for Labeo niloticus and 49, 45 and 977.5 for Clarias spp. It was noticed that clarias spp. has the highest edible meat percentage 46.75% followed by Labeo niloticus 38.82% and Oreochromis niloticus 33.39%, and there were significant differences (P < 0.05 among the three species. Chemical analysis for the samples was done to determine (protein, fat, ash and moisture contents. The results of protein contents examined were 62%, 61.5% and 61.5% for Oreochromis niloticus, Labeo niloticus and Clarias spp. respectively. Fat contents were 7.41%, 8.27% and 7.32% for Oreochromis niloticus, Labeo niloticus and Clarias spp. respectively. Moisture contents were 6.7%, 7.5% and 7.5% for Oreochromis niloticus, Labeo niloticus and Clarias spp. respectively. Ash contents were 5.90%, 6.05% and 6.85% for Oreochromis niloticus, Labeo niloticus and Clarias spp. respectively.

  5. Do differences in chemical composition of stem and cap of Amanita muscaria fruiting bodies correlate with topsoil type?

    Directory of Open Access Journals (Sweden)

    Stanisław Deja

    Full Text Available Fly agaric (Amanita muscaria was investigated using a 1H NMR-based metabolomics approach. The caps and stems were studied separately, revealing different metabolic compositions. Additionally, multivariate data analyses of the fungal basidiomata and the type of soil were performed. Compared to the stems, A. muscaria caps exhibited higher concentrations of isoleucine, leucine, valine, alanine, aspartate, asparagine, threonine, lipids (mainly free fatty acids, choline, glycerophosphocholine (GPC, acetate, adenosine, uridine, 4-aminobutyrate, 6-hydroxynicotinate, quinolinate, UDP-carbohydrate and glycerol. Conversely, they exhibited lower concentrations of formate, fumarate, trehalose, α- and β-glucose. Six metabolites, malate, succinate, gluconate, N-acetylated compounds (NAC, tyrosine and phenylalanine, were detected in whole A. muscaria fruiting bodies but did not show significant differences in their levels between caps and stems (P value>0.05 and/or OPLS-DA loading correlation coefficient <0.4. This methodology allowed for the differentiation between the fruiting bodies of A. muscaria from mineral and mineral-organic topsoil. Moreover, the metabolomic approach and multivariate tools enabled to ascribe the basidiomata of fly agaric to the type of topsoil. Obtained results revealed that stems metabolome is more dependent on the topsoil type than caps. The correlation between metabolites and topsoil contents together with its properties exhibited mutual dependences.

  6. The increasing burden of depression.

    Science.gov (United States)

    Lépine, Jean-Pierre; Briley, Mike

    2011-01-01

    Recent epidemiological surveys conducted in general populations have found that the lifetime prevalence of depression is in the range of 10% to 15%. Mood disorders, as defined by the World Mental Health and the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, have a 12-month prevalence which varies from 3% in Japan to over 9% in the US. A recent American survey found the prevalence of current depression to be 9% and the rate of current major depression to be 3.4%. All studies of depressive disorders have stressed the importance of the mortality and morbidity associated with depression. The mortality risk for suicide in depressed patients is more than 20-fold greater than in the general population. Recent studies have also shown the importance of depression as a risk factor for cardiovascular death. The risk of cardiac mortality after an initial myocardial infarction is greater in patients with depression and related to the severity of the depressive episode. Greater severity of depressive symptoms has been found to be associated with significantly higher risk of all-cause mortality including cardiovascular death and stroke. In addition to mortality, functional impairment and disability associated with depression have been consistently reported. Depression increases the risk of decreased workplace productivity and absenteeism resulting in lowered income or unemployment. Absenteeism and presenteeism (being physically present at work but functioning suboptimally) have been estimated to result in a loss of $36.6 billion per year in the US. Worldwide projections by the World Health Organization for the year 2030 identify unipolar major depression as the leading cause of disease burden. This article is a brief overview of how depression affects the quality of life of the subject and is also a huge burden for both the family of the depressed patient and for society at large. PMID:21750622

  7. CFD modeling of multiphase reacting flow in blast furnace shaft with layered burden

    International Nuclear Information System (INIS)

    The ironmaking blast furnace is a counter-current chemical reactor which includes the ascending gas flow and the counter-current descending porous bed (burden). A Computational Fluid Dynamics (CFD) model has been developed to simulate the multiphase reacting flow in blast furnace shaft. The gas flow dynamics, burden movement, chemical reactions, heat and mass transfer between the gas phase and burden phase are included in the CFD model. The blast furnace burden consists of alternative layers of iron ore and coke. A novel methodology is proposed to efficiently model the effects of alternative burden layer structure on gas flow, heat transfer, mass transfer and chemical reactions. Different reactions and heat transfer characteristics are applied for difference types of layer. In addition, the layered CFD model accurately predicts the Cohesive Zone (CZ) shape where the melting of solid burden taking place. The shape and location of the CZ are determined by an iterative method based on the ore temperature distribution. The theoretical formation and the methodology of the CFD model are presented and the model is applied to simulate industry blast furnaces. The proposed method can be applied to investigate the blast furnace shaft process and other moving bed system with periodic burden structure configuration. - Highlights: •A novel methodology is proposed to efficiently model the blast furnace shaft with layered burden. •The effects of layered burden on flow, heat transfer, and chemical reactions are considered in the model. •The shape and location of the cohesive zone is determined by an iterative method

  8. Atropinic (Anticholinergic) Burden in Parkinson's Disease.

    Science.gov (United States)

    De Germay, Sibylle; Montastruc, Jean-Louis; Rousseau, Vanessa; Chebane, Leila; Bondon-Guitton, Emmanuelle; Moulis, Florence; Durrieu, Genevieve; Bagheri, Haleh; Rascol, Olivier; Pariente, Antoine; Bégaud, Bernard; Montastruc, François

    2016-05-01

    Use of atropinic drugs remains controversial in Parkinson's disease (PD) because there is insufficient evidence about their efficacy and they can induce serious adverse drug reactions. Atropinic risk scales were developed to help to identify atropinic drugs in prescription forms and to evaluate their burden in clinical practice. In the present review, we discuss the few studies investigating atropinic burden in PD and present the results of our study indicating that atropinic drugs are still widely prescribed in PD (almost 3 of 5 prescriptions) with a clinically significant atropinic burden in around 1 of 6 PD patients. Drugs mainly responsible for high values of atropinic burden were those used for nonmotor symptoms. Clinically significant atropinic burdens were mainly induced by associations of several "low-risk" drugs. Physicians must be aware that in addition to classical atropinic antiparkinsonian drugs, many others (psychotropics) can contribute to increased atropinic burden in PD patients. © 2016 International Parkinson and Movement Disorder Society. PMID:27028036

  9. Burden of fungal disease in Ireland

    OpenAIRE

    Dorgan, Eileen; Denning, David W; McMullan, Ronan

    2015-01-01

    Our objective was to estimate the burden of fungal disease on the island of Ireland, as part of a coordinated project estimating the global burden. Published epidemiology data describing fungal infection in Ireland were identified. Population and underlying disease data were collected for 2010 and a structured set of assumptions were applied to estimate burden of fungal disease based on immunosuppression, chronic disease, and other demographic information indicating predisposition to fungal i...

  10. Do differences in chemical composition of stem and cap of Amanita muscaria fruiting bodies correlate with topsoil type?

    Science.gov (United States)

    Deja, Stanisław; Wieczorek, Piotr P; Halama, Marek; Jasicka-Misiak, Izabela; Kafarski, Paweł; Poliwoda, Anna; Młynarz, Piotr

    2014-01-01

    Fly agaric (Amanita muscaria) was investigated using a 1H NMR-based metabolomics approach. The caps and stems were studied separately, revealing different metabolic compositions. Additionally, multivariate data analyses of the fungal basidiomata and the type of soil were performed. Compared to the stems, A. muscaria caps exhibited higher concentrations of isoleucine, leucine, valine, alanine, aspartate, asparagine, threonine, lipids (mainly free fatty acids), choline, glycerophosphocholine (GPC), acetate, adenosine, uridine, 4-aminobutyrate, 6-hydroxynicotinate, quinolinate, UDP-carbohydrate and glycerol. Conversely, they exhibited lower concentrations of formate, fumarate, trehalose, α- and β-glucose. Six metabolites, malate, succinate, gluconate, N-acetylated compounds (NAC), tyrosine and phenylalanine, were detected in whole A. muscaria fruiting bodies but did not show significant differences in their levels between caps and stems (P value>0.05 and/or OPLS-DA loading correlation coefficient fly agaric to the type of topsoil. Obtained results revealed that stems metabolome is more dependent on the topsoil type than caps. The correlation between metabolites and topsoil contents together with its properties exhibited mutual dependences. PMID:25437454

  11. Assessment of factors affecting metal burden in the stone loach (Noemacheilus barbatulus L.).

    OpenAIRE

    Douben, P.E.T.

    1989-01-01

    This thesis is concerned with exposure of stone loach ( Noemacheilus barbatulus L.), a fairly common fish in British rivers, to cadmium and lead. The work described in this thesis was performed to assess the relative importance of different routes of entry (water, food and sediment) on the body burden of cadmium and lead in stone loach under field conditions. These studies were based on the premise that metabolic rate of stone loach is an important factor affecting metal burden. Metabolic rat...

  12. Classical ab initio van der Waals interactions from many-body dispersion and multipole machine learning models trained in chemical space

    CERN Document Server

    Bereau, Tristan; von Lilienfeld, O Anatole

    2015-01-01

    Accurate predictions of van der Waals forces require faithful models of dispersion, permanent and induced multipole-moments, as well as penetration and repulsion. We introduce a universal combined physics- and data-driven model of dispersion and multipole-moment contributions, respectively. Atomic multipoles are estimated "on-the-fly" for any organic molecule in any conformation using a machine learning approach trained on quantum chemistry results for tens of thousands of atoms in varying chemical environments drawn from thousands of organic molecules. Globally neutral, cationic, and anionic molecular charge states can be treated with individual models. Dispersion interactions are included via recently-proposed classical many-body potentials. For nearly one thousand intermolecular dimers, this approximate van der Waals model is found to reach an accuracy similar to that of state-of-the-art force fields, while bypassing the need for parametrization. Estimates of cohesive energies for the benzene crystal confi...

  13. Validation of the Burden Index of Caregivers (BIC), a multidimensional short care burden scale from Japan

    OpenAIRE

    Hagiwara Akiko; Akiyama Miki; Kawada Norikazu; Narita Yugo; Kayama Mami; Yamaguchi Aki; Miyashita Mitsunori; Suzukamo Yoshimi; Fukuhara Shunichi

    2006-01-01

    Abstract Background We constructed a concise multidimensional care burden scale that reflects circumstances unique to Japan, with a focus on intractable neurological diseases. We surveyed 646 family caregivers of patients with intractable neurological diseases or stroke using 28 preliminary care burden scale items obtained from qualitative research. The results were used to finalize the feeling of care burden scale (BIC: burden index of caregivers), and verify its reliability and validity. Me...

  14. Comparison of latex body paint with wetted gauze wipes for sampling the chemical warfare agents VX and sulfur mustard from common indoor surfaces.

    Science.gov (United States)

    Hernon-Kenny, Laura A; Behringer, Deborah L; Crenshaw, Michael D

    2016-05-01

    Comparison of solvent-wetted gauze with body paint, a peelable surface sampling media, for the sampling of the chemical warfare agents VX and sulfur mustard from nine surfaces was performed. The nine surfaces sampled are those typical of interior public venues and include smooth, rough, porous, and non-porous surfaces. Overall, solvent-wetted gauze (wipes) performed better for the recovery of VX from non-porous surfaces while body paint (BP) performed better for the porous surfaces. The average percent VX recoveries using wipes and BP, respectively, are: finished wood flooring, 86.2%, 71.4%; escalator handrail, 47.3%, 26.7%; stainless steel, 80.5%, 56.1%; glazed ceramic tile, 81.8%, 44.9%; ceiling tile, 1.77%, 13.1%; painted drywall 7.83%, 21.1%; smooth cement, 0.64%, 10.3%; upholstery fabric, 24.6%, 23.1%; unfinished wood flooring, 9.37%, 13.1%. Solvent-wetted gauze performed better for the recovery of sulfur mustard from three of the relatively non-porous surfaces while body paint performed better for the more porous surfaces. The average percent sulfur mustard recoveries using wipes and BP, respectively, are: finished wood flooring, 30.2%, 2.97%; escalator handrail, 4.40%, 4.09%; stainless steel, 21.2%, 3.30%; glazed ceramic tile, 49.7%, 16.7%; ceiling tile, 0.33%, 11.1%; painted drywall 2.05%, 10.6%; smooth cement, 1.20%, 35.2%; upholstery fabric, 7.63%, 6.03%; unfinished wood flooring, 0.90%, 1.74%. PMID:26990562

  15. BILINGUALISM: AN ASSET OR A BURDEN?

    OpenAIRE

    Ienneke Indra Dewi

    2008-01-01

    The article shows literary scholar opinion whether bilingualism is an asset or burden. The literary scholars see it from many aspects such as neuropsychological, cognitive, social, and psychology. From their research it found that generally bilingualism is an asset and not a burden. The analysis is also supported by argument and some examples from bilingual peoples.

  16. BILINGUALISM: AN ASSET OR A BURDEN?

    Directory of Open Access Journals (Sweden)

    Ienneke Indra Dewi

    2008-10-01

    Full Text Available The article shows literary scholar opinion whether bilingualism is an asset or burden. The literary scholars see it from many aspects such as neuropsychological, cognitive, social, and psychology. From their research it found that generally bilingualism is an asset and not a burden. The analysis is also supported by argument and some examples from bilingual peoples.

  17. Distribution of Major Health Risks: Findings from the Global Burden of Disease Study

    Directory of Open Access Journals (Sweden)

    Rodgers Anthony

    2004-01-01

    Full Text Available ABSTRACT Background Most analyses of risks to health focus on the total burden of their aggregate effects. The distribution of risk-factor-attributable disease burden, for example by age or exposure level, can inform the selection and targeting of specific interventions and programs, and increase cost-effectiveness. Methods and Findings For 26 selected risk factors, expert working groups conducted comprehensive reviews of data on risk-factor exposure and hazard for 14 epidemiological subregions of the world, by age and sex. Age-sex-subregion-population attributable fractions were estimated and applied to the mortality and burden of disease estimates from the World Health Organization Global Burden of Disease database. Where possible, exposure levels were assessed as continuous measures, or as multiple categories. The proportion of risk-factor-attributable burden in different population subgroups, defined by age, sex, and exposure level, was estimated. For major cardiovascular risk factors (blood pressure, cholesterol, tobacco use, fruit and vegetable intake, body mass index, and physical inactivity 43%-61% of attributable disease burden occurred between the ages of 15 and 59 y, and 87% of alcohol-attributable burden occurred in this age group. Most of the disease burden for continuous risks occurred in those with only moderately raised levels, not among those with levels above commonly used cut-points, such as those with hypertension or obesity. Of all disease burden attributable to being underweight during childhood, 55% occurred among children 1-3 standard deviations below the reference population median, and the remainder occurred among severely malnourished children, who were three or more standard deviations below median. Conclusions Many major global risks are widely spread in a population, rather than restricted to a minority. Population-based strategies that seek to shift the whole distribution of risk factors often have the potential to

  18. 76 FR 6123 - Reducing Regulatory Burden

    Science.gov (United States)

    2011-02-03

    ... Reducing Regulatory Burden AGENCY: Office of the General Counsel, Department of Energy. ACTION: Request for... FURTHER INFORMATION CONTACT: Daniel Cohen, Assistant General Counsel for Legislation, Regulation, and..., the President issued Executive Order 13563, ``Improving Regulation and Regulatory Review,'' to...

  19. Single Working Moms Carry a Heart Burden

    Science.gov (United States)

    ... Single Working Moms Carry a Heart Burden Stress, finances may boost cardiovascular risks for U.S. mothers, study ... the June 16 online edition of the American Journal of Public Health . SOURCES: Frank van Lenthe, Ph. ...

  20. Burden of Child Maltreatment in China

    OpenAIRE

    Fang, Xiangming; Fry, Deborah; Ji, Kai; Finkelhor, David; Chen, Jingqi; Lannen, Patricia; Dunne, Michael

    2015-01-01

    Abstract Objective To estimate the health and economic burdens of child maltreatment in China. Methods We did a systematic review for studies on child maltreatment in China using PubMed, Embase, PsycInfo, CINAHL-EBSCO, ERIC and the Chinese National Knowledge Infrastructure databases. We did meta-analyses of studies that met inclusion criteria to estimate the prevalence of child neglect and child physical, emotional and sexual abuse. We used data from the 2010 global burden of disease estimate...

  1. Administrative burdens of employment in Hungary

    OpenAIRE

    Fruzsina Bognar; Agnes Szabo-Morvai

    2011-01-01

    In this study we analyze the perception of administrative burdens of employment in Hungary. In comparison with the members of the European Union, the supply side of the Hungarian labor market is lagging behind. This means that the ratio of the inactive is relatively high. Moreover, there is also a relatively large gap in the demand of labor. It is of high importance to analyze the effect of administrative burden on economic achievement and employment, for two reasons. First, the extent of adm...

  2. Understanding Social Support Burden Among Family Caregivers

    OpenAIRE

    Wittenberg-Lyles, Elaine; Washington, Karla; Demiris, George; Parker Oliver, Debra; Shaunfield, Sara

    2013-01-01

    Despite the abundance of research on social support, both as a variable in larger studies and as a central focus of examination, there is little consensus about the relationship between social support and health outcomes. Current social support measures typically account only for frequency and size of network and a paucity of research exists that has explained social support burden, defined as the burden associated with accessing and receiving support from others. We analyzed audio-recorded d...

  3. The Possible Effect Of Tamoxifen Vs Whole Body Irradiation Treatment On Thyroid Hormones in Female Rats Bearing Mammary Tumors Chemically Induced

    International Nuclear Information System (INIS)

    Breast cancer is the most common malignancy among women in most developed and developing regions of the world. In women, this drug has tissuespecific effects, acting as an estrogen antagonist on the breast, and as an estrogen agonist on bone, lipid metabolism (increasing high-density lipoprotein cholesterol and decreasing low-density lipoprotein cholesterol), and the endometrium. Thyroid hormones act on almost all organs throughout the body and regulate the basal metabolism of the organism. Thyroid hormone can also stimulate the proliferation in vitro of certain tumor cell lines. The aim of the present study is to evaluate the significant value of tamoxifen and/or irradiation treatment on thyroid hormones in breast cancer bearing female rats. Forty two female Sprague-Dawely rats randomly divided into seven groups and the effect of tamoxifen and post-irradiation was studied on breast cancer chemically induced. The results shows a T4 and estradiol levels not T3 were altered in different experimental groups. It could be concluded that irradiation-induced changes in the composition of the mammary microenvironment promote the expression of neoplastic potential by affecting both estradiol and thyroid hormones, and tamoxifen may alter the thyroid hormones. Irradiation and tamoxifen administration may have worth effects on T4 and estradiol levels and it is recommended to further studies towards the bystander effect of radiation and tamoxifen on the tissue culture and molecular biology scale.

  4. Contribution of maternal radionuclide burdens to prenatal radiation doses: Relationships between annual limits on intake and prenatal doses

    International Nuclear Information System (INIS)

    This addendum describes approaches for calculating and expressing radiation doses to the embryo/fetus from maternal intakes of radionuclides at levels corresponding to fractions or multiples of the Annual Limits on Intake (ALI). Information, concerning metabolic or dosimetric characteristics and the placental transfer of selected, occupationally significant radionuclides was presented in NUREG/CR-5631, Revision 1. That information was used to estimate levels of radioactivity in the embryo/fetus as a function of stage of pregnancy and time after entry. Extension of MIRD methodology to accommodate gestational-stage-dependent characteristics allowed dose calculations for the simplified situation based on introduction of 1 μCi into the woman's transfer compartment (blood). The expanded scenarios in this addendum include repeated or chronic ingestion or inhalation intakes by a woman during pregnancy and body burdens at the beginning of pregnancy. Tables present dose equivalent to the embryo/fetus relative to intakes of these radionuclides in various chemical or physical forms and from preexisting maternal burdens corresponding to ALI; complementary intake values (fraction of an ALI and μCi) that yield a dose equivalent of 0.05 rem are included. Similar tables give these measures of dose equivalency to the uterus from intakes of radionuclides for use as surrogates for embryo/fetus dose when biokinetic information is not available

  5. Metabolic concentration of lipid soluble organochlorine burdens in the blubber of southern hemisphere humpback whales through migration and fasting.

    Science.gov (United States)

    Bengtson Nash, Susan M; Waugh, Courtney A; Schlabach, Martin

    2013-08-20

    Southern hemisphere humpback whales undertake the longest migrations and associated periods of fasting of any mammal. Fluctuations in lipid energy stores are known to profoundly affect the toxicokinetics of lipophilic organochlorine compound (OC) burdens. Results from blubber biopsy sampling of adult, male humpback whales at two time points of the annual migration journey revealed dramatic concentration effects for the majority of OC compounds. The observed concentration effect was, however, not linear with measured average blubber lipid loss indicating significant redistribution of OCs and hence the importance of alternate lipid depots for meeting the energetic demands of the migration journey. Applying lipophilic OC burdens as novel tracers of whole-body lipid dynamics, the observed average concentration index suggests an average individual weight loss of 13% over 4 months of the migration journey. This value is based upon lipid derived energy and is in good agreement with previous weight prediction formulas. Notably, however, these estimates may greatly underestimate individual weight loss if significant protein catabolism occurs. Biomagnification factors between migrating southern hemisphere humpback whales and their principal prey item, Antarctic krill, closely resembled those of baleen whales feeding on herbivorous zooplankton in the Arctic. This study emphasizes the importance of considering prolonged periods of food deprivation when assessing chemical risks posed to wildlife. This is of particular importance for Polar biota adapted to extremes in ecosystem productivity. PMID:23859482

  6. Validation of the Burden Index of Caregivers (BIC, a multidimensional short care burden scale from Japan

    Directory of Open Access Journals (Sweden)

    Hagiwara Akiko

    2006-08-01

    Full Text Available Abstract Background We constructed a concise multidimensional care burden scale that reflects circumstances unique to Japan, with a focus on intractable neurological diseases. We surveyed 646 family caregivers of patients with intractable neurological diseases or stroke using 28 preliminary care burden scale items obtained from qualitative research. The results were used to finalize the feeling of care burden scale (BIC: burden index of caregivers, and verify its reliability and validity. Methods The survey was conducted among caregivers providing home health care to patients with intractable neurological diseases (PD [Parkinson's disease], SCD [spinocerebellar degeneration], MSA [multiple system atrophy], and ALS [amyotrophic lateral sclerosis] or CVA (cerebrovascular accident using a mailed, self-administered questionnaire between November, 2003 and May, 2004. Results Response rates for neurological and CVA caregivers were 50% and 67%, respectively, or 646 in total (PD, 279; SCD, 78; MSA, 39; ALS, 30; and CVA, 220. Item and exploratory factor analyses led to a reduction to 11 items, comprising 10 items from the 5 domains of time-dependent burden, emotional burden, existential burden, physical burden, and service-related burden; and 1 item on total burden. Examination of validity showed a moderate correlation between each domain of the BIC and the SF-8 (Health related quality of life scale, Short Form-8, while the correlation coefficient of the overall BIC and CES-D was 0.62. Correlation between the BIC and ZBI, a preexisting care burden scale, was high (r = 0.84, while that with the time spent on providing care was 0.47. The ICC (Intraclass correlation coefficient by test-retest reliability was 0.83, and 0.68 to 0.80 by individual domain. Conclusion These results show that the BIC, a new care burden scale comprising 11 items, is highly reliable and valid.

  7. Psychological burden of food allergy

    Institute of Scientific and Technical Information of China (English)

    Martin Teufel; Tilo Biedermann; Nora Rapps; Constanze Hausteiner; Peter Henningsen; Paul Enck; Stephan Zipfel

    2007-01-01

    One fifth of the population report adverse reactions to food. Reasons for these symptoms are heterogeneous,varying from food allergy, food intolerance, irritable bowel syndrome to somatoform or other mental disorders. Literature reveals a large discrepancy between truly diagnosed food allergy and reports of food allergy symptoms by care seekers. In most studies currently available the characterization of patient groups is incomplete, because they did not distinguish between immunologic reactions and other kinds of food reactions.In analysing these adverse reactions, a thorough physical and psychological diagnostic approach is important. In our qualitative review, we present those diagnostic measures that are evidenced-based as well as clinically useful, and discuss the various psychological dimensions of adverse reactions to food. It is important to acknowledge the complex interplay between body and mind: Adults and children suffering from food allergy show impaired quality of life and a higher level of stress and anxiety. Pavlovian conditioning of adverse reactions plays an important role in maintaining symptoms. The role of personality, mood, or anxiety in food reactions is debatable. Somatoform disorders ought to be identified early to avoid lengthy and frustrating investigations. A future task will be to improve diagnostic algorithms, to describe psychological aspects in clearly characterised patient subgroups, and to develop strategies for an optimized management of the various types of adverse reactions to food.

  8. Psychological burden of food allergy

    Science.gov (United States)

    Teufel, Martin; Biedermann, Tilo; Rapps, Nora; Hausteiner, Constanze; Henningsen, Peter; Enck, Paul; Zipfel, Stephan

    2007-01-01

    One fifth of the population report adverse reactions to food. Reasons for these symptoms are heterogeneous, varying from food allergy, food intolerance, irritable bowel syndrome to somatoform or other mental disorders. Literature reveals a large discrepancy between truly diagnosed food allergy and reports of food allergy symptoms by care seekers. In most studies currently available the characterization of patient groups is incomplete, because they did not distinguish between immunologic reactions and other kinds of food reactions. In analysing these adverse reactions, a thorough physical and psychological diagnostic approach is important. In our qualitative review, we present those diagnostic measures that are evidenced-based as well as clinically useful, and discuss the various psychological dimensions of adverse reactions to food. It is important to acknowledge the complex interplay between body and mind: Adults and children suffering from food allergy show impaired quality of life and a higher level of stress and anxiety. Pavlovian conditioning of adverse reactions plays an important role in maintaining symptoms. The role of personality, mood, or anxiety in food reactions is debatable. Somatoform disorders ought to be identified early to avoid lengthy and frustrating investigations. A future task will be to improve diagnostic algorithms, to describe psychological aspects in clearly characterised patient subgroups, and to develop strategies for an optimized management of the various types of adverse reactions to food. PMID:17659692

  9. Post-growth thermal oxidation of wurtzite InN thin films into body-center cubic In2O3 for chemical/gas sensing applications

    International Nuclear Information System (INIS)

    Post-growth thermal oxidations of InN have been studied using high-resolution x-ray diffraction (HRXRD) and secondary ion-mass spectroscopy (SIMS). The InN thin films, having relative high crystal quality, were grown by metal–organic chemical vapor deposition (MOCVD) on c-sapphire substrates using InGaN/GaN buffer layers. HRXRD reveals that oxidation of wurtzite InN into body-center cubic In2O3 occurred at elevated temperatures. A Si3N4 encapsulation improves the crystal quality of In2O3 oxidized by using conventional rapid thermal annealing (RTA) but it results in the presence of undesired metallic indium. Cycle-RTA not only improves the crystal quality but also avoids the byproduct of metallic indium. SIMS depth profile, using contaminate elements as the ‘interface markers,’ provide evidence that the oxidation of InN is dominated by oxygen inward diffusion mechanism. Together with the HRXRD results, we conclude that the crystal quality of the resultant In2O3/InN heterostructure is mainly controlled by the balance between the speeds of oxygen diffusion and InN thermal dissociation, which can be effectively tuned by cycle-RTA. The obtained In2O3/InN heterostructures can be fundamental materials for studying high speed chemical/gas sensing devices. - Graphical abstract: Oxidation of h-InN into bcc-In2O3 has been realized at elevated temperatures. A Si3N4 cap improves the crystal quality of In2O3 oxidized by conventional RTA but it results in the presence of undesired metallic indium. Cycle-RTA not only improves the crystal quality but also avoids the byproduct of metallic indium. SIMS depth profiles provide evidence that the oxidation of InN is dominated by oxygen inward diffusion mechanism. The crystal quality of the resultant In2O3/InN heterostructure is mainly controlled by the balance between the speeds of oxygen diffusion and InN thermal dissociation, which can be effectively tuned by cycle-RTA. - Highlights: • Oxidation of h-InN into bcc-In2O3 has been

  10. The disease burden of Taenia solium cysticercosis in Cameroon.

    Directory of Open Access Journals (Sweden)

    Nicolas Praet

    Full Text Available BACKGROUND: Taenia solium cysticercosis is an important zoonosis in many developing countries. Human neurocysticercosis is recognised as an important cause of epilepsy in regions where the parasite occurs. However, it is largely underreported and there is a lack of data about the disease burden. Because a body of information on human and porcine cysticercosis in Cameroon is becoming available, the present study was undertaken to calculate the impact of this neglected zoonosis. METHODS: Both the cost and Disability Adjusted Life Year (DALY estimations were applied. All necessary parameters were collected and imported in R software. Different distributions were used according to the type of information available for each of the parameters. FINDINGS: Based on a prevalence of epilepsy of 3.6%, the number of people with neurocysticercosis-associated epilepsy was estimated at 50,326 (95% CR 37,299-65,924, representing 1.0% of the local population, whereas the number of pigs diagnosed with cysticercosis was estimated at 15,961 (95% CR 12,320-20,044, which corresponds to 5.6% of the local pig population. The total annual costs due to T. solium cysticercosis in West Cameroon were estimated at 10,255,202 Euro (95% CR 6,889,048-14,754,044, of which 4.7% were due to losses in pig husbandry and 95.3% to direct and indirect losses caused by human cysticercosis. The monetary burden per case of cysticercosis amounts to 194 Euro (95% CR 147-253. The average number of DALYs lost was 9.0 per thousand persons per year (95% CR 2.8-20.4. INTERPRETATION: This study provides an estimation of the costs due to T. solium cysticercosis using country-specific parameters and including the human as well as the animal burden of the zoonotic disease. A comparison with a study in South Africa indicates that the cost of inactivity, influenced by salaries, plays a predominant role in the monetary burden of T. solium cysticercosis. Therefore, knowing the salary levels and the

  11. Burden of childhood-onset arthritis

    Directory of Open Access Journals (Sweden)

    Hassett Afton L

    2010-07-01

    Full Text Available Abstract Juvenile arthritis comprises a variety of chronic inflammatory diseases causing erosive arthritis in children, often progressing to disability. These children experience functional impairment due to joint and back pain, heel pain, swelling of joints and morning stiffness, contractures, pain, and anterior uveitis leading to blindness. As children who have juvenile arthritis reach adulthood, they face possible continuing disease activity, medication-associated morbidity, and life-long disability and risk for emotional and social dysfunction. In this article we will review the burden of juvenile arthritis for the patient and society and focus on the following areas: patient disability; visual outcome; other medical complications; physical activity; impact on HRQOL; emotional impact; pain and coping; ambulatory visits, hospitalizations and mortality; economic impact; burden on caregivers; transition issues; educational occupational outcomes, and sexuality. The extent of impact on the various aspects of the patients', families' and society's functioning is clear from the existing literature. Juvenile arthritis imposes a significant burden on different spheres of the patients', caregivers' and family's life. In addition, it imposes a societal burden of significant health care costs and utilization. Juvenile arthritis affects health-related quality of life, physical function and visual outcome of children and impacts functioning in school and home. Effective, well-designed and appropriately tailored interventions are required to improve transitioning to adult care, encourage future vocation/occupation, enhance school function and minimize burden on costs.

  12. Environmental Benefits and Burdens of Phosphorus Recovery from Municipal Wastewater.

    Science.gov (United States)

    Bradford-Hartke, Zenah; Lane, Joe; Lant, Paul; Leslie, Gregory

    2015-07-21

    The environmental benefits and burdens of phosphorus recovery in four centralized and two decentralized municipal wastewater systems were compared using life cycle assessment (LCA). In centralized systems, phosphorus recovered as struvite from the solids dewatering liquid resulted in an environmental benefit except for the terrestrial ecotoxicity and freshwater eutrophication impact categories, with power and chemical use offset by operational savings and avoided fertilizer production. Chemical-based phosphorus recovery, however, generally required more resources than were offset by avoided fertilizers, resulting in a net environmental burden. In decentralized systems, phosphorus recovery via urine source separation reduced the global warming and ozone depletion potentials but increased terrestrial ecotoxicity and salinization potentials due to application of untreated urine to land. Overall, mineral depletion and eutrophication are well-documented arguments for phosphorus recovery; however, phosphorus recovery does not necessarily present a net environmental benefit. While avoided fertilizer production does reduce potential impacts, phosphorus recovery does not necessarily offset the resources consumed in the process. LCA results indicate that selection of an appropriate phosphorus recovery method should consider both local conditions and other environmental impacts, including global warming, ozone depletion, toxicity, and salinization, in addition to eutrophication and mineral depletion impacts. PMID:26121005

  13. The burden of stroke in Pakistan.

    Science.gov (United States)

    Khealani, Bhojo A; Wasay, Mohammad

    2008-11-01

    Epidemiologic literature on stroke burden, patterns of stroke is almost non existent from Pakistan. However, several hospital-based case series on the subject are available, mainly published in local medical journals. Despite the fact that true stroke incidence and prevalence of stroke in Pakistan is not known, the burden is assumed to be high because of highly prevalent stroke risk factors (hypertension, diabetes mellitus, coronary artery disease, dyslipidemia and smoking) in the community. High burden of these conventional stroke risk factors is further compounded by lack of awareness, poor compliance hence poor control, and inappropriate management/treatment practices. In addition certain risk factors like rheumatic valvular heart disease may be more prevalent in Pakistan. We reviewed the existing literature on stroke risk factors in community, the risk factor prevalence among stroke patients, patterns of stroke, out come of stroke, availability of diagnostic services/facilities related to stroke and resources for stroke care in Pakistan. PMID:18811747

  14. The global burden of periodontal disease

    DEFF Research Database (Denmark)

    Petersen, Poul E; Ogawa, Hiroshi

    2012-01-01

    Chronic diseases are accelerating globally, advancing across all regions and pervading all socioeconomic classes. Unhealthy diet and poor nutrition, physical inactivity, tobacco use, excessive use of alcohol and psychosocial stress are the most important risk factors. Periodontal disease is a...... component of the global burden of chronic disease, and chronic disease and periodontal disease have the same essential risk factors. In addition, severe periodontal disease is related to poor oral hygiene and to poor general health (e.g. the presence of diabetes mellitus and other systemic diseases). The...... present report highlights the global burden of periodontal disease: the ultimate burden of periodontal disease (tooth loss), as well as signs of periodontal disease, are described from World Health Organization (WHO) epidemiological data. High prevalence rates of complete tooth loss are found in upper...

  15. Epidemiology and burden of alopecia areata: a systematic review

    Directory of Open Access Journals (Sweden)

    Villasante Fricke AC

    2015-07-01

    Full Text Available Alexandra C Villasante Fricke, Mariya MitevaDepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USABackground: Alopecia areata (AA is an autoimmune disorder characterized by patches of non-scarring alopecia affecting scalp and body hair that can be psychologically devastating. AA is clinically heterogenous, and its natural history is unpredictable. There is no preventative therapy or cure.Objective: The objective of this study is to provide an evidence-based systematic review on the epidemiology and the burden of AA.Methods and selection criteria: A search was conducted of the published, peer-reviewed literature via PubMed, Embase, and Web of Science. Studies published in English within the last 51 years that measured AA’s incidence, prevalence, distribution, disability-adjusted life years (DALYs, quality of life, and associated psychiatric and medical comorbidities were included. Two authors assessed studies and extracted the data.Results: The lifetime incidence of AA is approximately 2% worldwide. Both formal population studies found no sex predominance. First onset is most common in the third and fourth decades of life but may occur at any age. An earlier age of first onset corresponds with an increased lifetime risk of extensive disease. Global DALYs for AA were calculated at 1,332,800 in 2010. AA patients are at risk for depression and anxiety, atopy, vitiligo, thyroid disease, and other autoimmune conditions.Conclusion: AA is the most prevalent autoimmune disorder and the second most prevalent hair loss disorder after androgenetic alopecia, and the lifetime risk in the global population is approximately 2%. AA is associated with psychiatric and medical comorbidities including depression, anxiety, and several autoimmune disorders, and an increased global burden of disease.Keywords: hair loss, hair, prevalence, incidence, burden of disease

  16. Metallic Burden of Deciduous Teeth and Childhood Behavioral Deficits

    Directory of Open Access Journals (Sweden)

    Tony J.H. Chan

    2015-06-01

    Full Text Available Attention Deficit/Hyperactivity Disorder (ADHD affects 5%–8% of children in the U.S. (10% of males and 4% of females. The contributions of multiple metal exposures to the childhood behavioral deficits are unclear, although particular metals have been implicated through their neurotoxicity. The objective of this study was to test the hypothesis that the body burden of Mn is positively correlated with ADHD symptoms. We also investigated the putative roles of Ca, Fe, Pb, and Hg. We collected shed molars from 266 children (138 boys and 128 girls who lost a tooth between 11 and 13 years of age. The molars were analyzed for metals using ICP-OES. The third grade teacher of each child completed the Teacher’s Disruptive Behavior Disorders Rating Scale (DBD to produce a score for “Total Disruptive Behavior” and subscale scores for “Attention Deficit Hyperactivity Disorder”, Hyperactivity/Impulsivity, Inattention, and Oppositional/Defiant. The mean Mn, Fe, Pb and Ca concentrations found in teeth was 6.1 ± 5.7 µg/g, 22.7 ± 24.1 µg/g, 0.9 ± 1.4 µg/g, and 6.0 × 105 ± 1.6 × 105 µg/g, respectively. Hg was not detected. No significant association was found between Mn and behavioral deficits. Ca was significantly negatively associated, and Pb showed a significant positive association with Hyperactivity/Impulsivity, Inattention, and Oppositional/Defiant Disorders. These findings call into question the putative independent association of manganese exposure and behavioral deficits in children, when the balance of other metallic burden, particularly Ca and Pb burdens play significant roles.

  17. 77 FR 31548 - Reducing Regulatory Burden

    Science.gov (United States)

    2012-05-29

    ...; ] DEPARTMENT OF ENERGY 5 CFR Chapter XXII 10 CFR Chapters II, III, X Reducing Regulatory Burden AGENCY: Office... Regulation and Regulatory Review,'' is extended to June 19, 2012. DATES: DOE will accept comments, data, and... INFORMATION CONTACT: Daniel Cohen, Assistant General Counsel for Legislation, Regulation, and...

  18. 77 FR 28518 - Reducing Regulatory Burden

    Science.gov (United States)

    2012-05-15

    ...; ] DEPARTMENT OF ENERGY 5 CFR Chapter XXII 10 CFR Chapters II, III, X Reducing Regulatory Burden AGENCY: Office... its implementation of Executive Order 13563, ``Improving Regulation and Regulatory Review,'' issued by... INFORMATION CONTACT: Daniel Cohen, Assistant General Counsel for Legislation, Regulation, and...

  19. 77 FR 47328 - Reducing Regulatory Burden

    Science.gov (United States)

    2012-08-08

    ...; ] DEPARTMENT OF ENERGY 5 CFR Chapter XXII 10 CFR Chapters II, III, X Reducing Regulatory Burden AGENCY: Office... its implementation of Executive Order 13563, ``Improving Regulation and Regulatory Review,'' issued by... . FOR FURTHER INFORMATION CONTACT: Daniel Cohen, Assistant General Counsel for Legislation,...

  20. 76 FR 75798 - Reducing Regulatory Burden

    Science.gov (United States)

    2011-12-05

    ...; ] DEPARTMENT OF ENERGY 5 CFR Chapter XXIII 10 CFR Chapters II, III, X Reducing Regulatory Burden AGENCY: Office... its implementation of Executive Order 13563, ``Improving Regulation and Regulatory Review,'' issued by... General Counsel for Legislation, Regulation, and Energy Efficiency, U.S. Department of Energy, Office...

  1. Radiation burden in children from radionuclide examinations

    International Nuclear Information System (INIS)

    The value of ICRP Publication No. 53 for assessing the radiation burden from radiopharmaceuticals in children is stressed, and effective dose equivalent data HE per unit activity of the radiopharmaceutical applied are reproduced from this publication for typical radiopharmaceuticals used in Czechoslovakia. The data are compared with those by other authors (P.A.). 1 tab., 6 refs

  2. Burden of fungal disease in Ireland.

    Science.gov (United States)

    Dorgan, Eileen; Denning, David W; McMullan, Ronan

    2015-04-01

    Our objective was to estimate the burden of fungal disease on the island of Ireland, as part of a coordinated project estimating the global burden. Published epidemiology data describing fungal infection in Ireland were identified. Population and underlying disease data were collected for 2010 and a structured set of assumptions were applied to estimate burden of fungal disease based on immunosuppression, chronic disease, and other demographic information indicating predisposition to fungal infection. From Ireland's population of 6.4 million, we estimate 117, 000 patients develop significant fungal disease each year. By far the most common fungal disease is recurrent Candida vaginitis, with an estimated 95, 000 episodes annually (3000 per 100 000 women). Other fungal diseases which may be less well recognized are severe asthma with fungal sensitization and allergic bronchopulmonary aspergillosis, with estimated episodes per year of 11, 700 and 9000, respectively (182 and 140 per 100, 000 population, respectively). The model also estimates 450 episodes of invasive aspergillosis, 200 of chronic pulmonary aspergillosis, 600 of oesophageal candidiasis and 450 of candidaemia per year (7, 3, 9 and 6 episodes per 100, 000 population, respectively). This is, we believe, the first attempt to estimate the burden of fungal disease in our population and provides a basis for estimating its impact on human health and resource use. PMID:25596121

  3. Mobilization of plutonium burdens during pregnancy

    International Nuclear Information System (INIS)

    The mobilization and distribution of previously deposited 239Pu was compared in pregnant rats (15 and 20 days of gestation) and nonpregnant controls. Pregnancy had little effect on 239Pu tissue burdens and only minimal activity appeared in the fetoplacental unit. Marked differences were observed in tracer 45Ca deposition patterns between the experimental groups

  4. Investigation the burden of mentally ill careers’

    Directory of Open Access Journals (Sweden)

    Statharou A.

    2011-04-01

    Full Text Available Aim: of this research was to investigate, in Greek population, the degree of burden of caregivers of psychiatric patients, the ratio of burden and demographic and other factors. Finally, the purpose of this study was to evaluate the effect which, the burden, has on quality of life and mental health of caregivers. Materials and methods: For this purpose, specially constructed questionnaires were administered to 122 carers in structures belonging to the University Psychiatric Department of Eginition Hospital. Except of demographic data and variables related to their relative-patient, the participants filled out four psychometric tools: a the McMaster Family Assessment Device, b the quality of life questionnaire SF-12, c Zung’s self-rated depression scale and d the trait part of Spielberger’s State-Trait Anxiety Inventory. The study’s participants had variable age, family status, education, profession, gender and relationship with the psychiatric patient who was their relative. Results : The statistical analysis of the data showed that the carers reported low levels of health-related quality of life, both in the physical and in the mental component. The 20-40 years age group, the working and more educated class reported bigger distress in the physical dimension; in the mental dimension apart from the previous age group, worse quality of life was reported by relatives other than spouses. On the other hand, the burden levels show for the carers in our sample, were high in comparison with findings from other studies. Pensioners and/or homemakers, married, parents of psychiatric patients who cared for their relatives for a long period of time were proven more adjusted and resistant to burden. Older ages reported, though, higher levels of depression and anxiety. 20.8% of the participants gave answers indicative of clinical depression. In general, anxiety and depression as well as the mental component of the quality of life were found to be

  5. Lifting The Burden: The Global Campaign to Reduce the Burden of Headache Worldwide

    OpenAIRE

    Steiner, T. J.

    2005-01-01

    Lifting The Burden envisions a future world in which headache disorders are recognized everywhere as real, disabling and deserving of medical care to which all who need it have access without artificial barriers.

  6. The burden of disease in Spain: results from the global burden of disease study 2010

    OpenAIRE

    Haro, Josep Maria; Tyrovolas, Stefanos; Garin, Noe; Diaz-Torne, Cesar; Carmona, Loreto; Sanchez-Riera, Lidia; Perez-Ruiz, Fernando; Murray, Christopher JL

    2014-01-01

    Background We herein evaluate the Spanish population’s trends in health burden by comparing results of two Global Burden of Diseases, Injuries, and Risk Factors Studies (the GBD studies) performed 20 years apart. Methods Data is part of the GBD study for 1990 and 2010. We present results for mortality, years of life lost (YLLs), years lived with disability, and disability-adjusted life years (DALYs) for the Spanish population. Uncertainty intervals for all measures have been estimated. Result...

  7. The burden of inhibitors in haemophilia patients.

    Science.gov (United States)

    Walsh, Christopher E; Jiménez-Yuste, Víctor; Auerswald, Guenter; Grancha, Salvador

    2016-08-31

    The burden of disease in haemophilia patients has wide ranging implications for the family and to society. There is evidence that having a current inhibitor increases the risk of morbidity and mortality. Morbidity is increased by the inability to treat adequately and its consequent disabilities, which then equates to a poor quality of life compared with non-inhibitor patients. The societal cost of care, or `burden of inhibitors', increases with the ongoing presence of an inhibitor. Therefore, it is clear that successful eradication of inhibitors by immune tolerance induction (ITI) is the single most important milestone one can achieve in an inhibitor patient. The type of factor VIII (FVIII) product used in ITI regimens varies worldwide. Despite ongoing debate, there is in vitro and retrospective clinical evidence to support the use of plasma-derived VWF-containing FVIII concentrates in ITI regimens in order to achieve early and high inhibitor eradication success rates. PMID:27528280

  8. Mineral lung burden of an urban population

    Science.gov (United States)

    Paoletti, L.; Falchi, M.; Batisti, D.; Carrieri, M. P.; Petrelli, M. G.; Ciallella, C.; Donelli, G.

    A study was carried out on mineral lung burden in 85 autopsy cases who died accidentally. Subjects of both sexes aged from 15 to 70 years were selected from all the autopsies performed at the Institute of Forensic Medicine in Rome. These subjects were living in an urban area and were not affected by neoplasm diseases. All selected subjects were residing in Rome at the time of their death. Information on years of legal residence in urban areas, smoking habits and occupational history were obtained by interviews with relatives. Lung parenchyma samples were obtained from the right upper lobe. The mineral particulate matter present in the tissue samples was studied by means of analytical transmission electron microscopy (ATEM) techniques: 16 mineral varieties and 22 metallic elements were identified. Smoke, age and residence seem to have influence on the lung burden.

  9. Burden of disease of dietary exposure to acrylamide in Denmark

    DEFF Research Database (Denmark)

    Jakobsen, Lea Sletting; Granby, Kit; Knudsen, Vibeke Kildegaard;

    2016-01-01

    Acrylamide (AA) is a process-contaminant that potentially increases the risk of developing cancer in humans. AA is formed during heat treatment of starchy foods and detected in a wide range of commonly consumed products. Increased focus on risk ranking and prioritization of major causes of disease...... makes it relevant to estimate the impact that exposure to chemical contaminants and other hazards in food have on health. In this study, we estimated the burden of disease (BoD) caused by dietary exposure to AA, using disability adjusted life years (DALY) as health metric.We applied an exposure...... due to exposure to AA through foods, as estimated by the most conservative approach.This result should be used to inform risk management decisions and for comparison with BoD of other food-borne hazards for prioritizing policies. However, our study shows that careful evaluation of methodological...

  10. Understanding the Burden of Adult Female Acne

    OpenAIRE

    Tanghetti, Emil A.; Kawata, Ariane K.; Daniels, Selena R.; Yeomans, Karen; Burk, Caroline T; Callender, Valerie D.

    2014-01-01

    Objective: Typically regarded as an adolescent condition, acne among adult females is also prevalent. Limited data are available on the clinical characteristics and burden of adult female acne. The study objective was to describe clinical characteristics and psychosocial impact of acne in adult women. Design: Cross-sectional, web-based survey. Setting: Data were collected from a diverse sample of United States females. Participants: Women ages 25 to 45 years with facial acne (≥25 visible lesi...

  11. The injury mortality burden in Guinea

    Directory of Open Access Journals (Sweden)

    Mamady Keita

    2012-09-01

    Full Text Available Abstract Background The injury mortality burden of Guinea has been rarely addressed. The paper aimed to report patterns of injury mortality burden in Guinea. Methods We retrieved the mortality data from the Guinean Annual Health Statistics Report 2007. The information about underlying cause of deaths was collected based on Guinean hospital discharge data, Hospital Mortuary and City Council Mortuary data. The causes of death are coded in the 9th International Classification of Diseases (ICD-9. Multivariate Poisson regression was used to test the impacts of sex and age on mortality rates. The statistical analyses were performed using Statatm 10.0. Results In 2007, 7066 persons were reported dying of injuries in Guinea (mortality: 72.8 per 100,000 population. Transportation, fire/burn, falls, homicide and drowning were the five leading causes of fatal injuries for the whole population, accounting for 37%, 22%, 12%, 10% and 6% of total deaths, respectively. In general, age-specific injury causes displayed similar patterns of the whole population except that poisoning replaced falls as a leading cause among children under five years old. Males were at 30-50% more risk of dying from six commonest causes than females and old age groups had higher injury mortality rates than younger age groups. Conclusion Transportation, fire/burn, falls, homicide, and drowning accounted for the majority of total injury mortality burden in Guinea. Males and old adults were high-risk population of fatal injuries and should be targeted by injury prevention. Lots of work is needed to improve weak capacities for injury control in order to reduce the injury mortality burden.

  12. The economic burden of Clostridium difficile

    OpenAIRE

    McGlone, S. M.; Bailey, R R; Zimmer, S. M.; Popovich, M. J.; Y. Tian; Ufberg, P.; Muder, R R; Lee, B Y

    2011-01-01

    Although Clostridium difficile (C. difficile) is the leading cause of infectious diarrhoea in hospitalized patients, the economic burden of this major nosocomial pathogen for hospitals, third-party payers and society remains unclear. We developed an economic computer simulation model to determine the costs attributable to healthcare-acquired C. difficile infection (CDI) from the hospital, third-party payer and societal perspectives. Sensitivity analyses explored the effects of varying the cos...

  13. Burden of Illness in Bipolar Depression

    OpenAIRE

    Manning, J. Sloan

    2005-01-01

    Bipolar depression is the underrecognized and unappreciated phase of bipolar disorder. Nevertheless, bipolar depression is responsible for much of the morbidity and mortality associated with the disorder. Depressive symptoms are far more prevalent than hypomanic or manic symptoms in bipolar patients, and they are associated with a heavier burden of illness, including reduced functioning, increased risk of suicidal acts, and high economic costs. Because most patients with bipolar disorder pres...

  14. Occupational cancer burden in Great Britain

    OpenAIRE

    Rushton, Lesley; Hutchings, Sally J; Fortunato, Lea; Young, Charlotte; Evans, Gareth S; Brown, Terry; Bevan, Ruth; Slack, Rebecca; Holmes, Phillip; Bagga, Sanjeev; Cherrie, John W; van Tongeren, Martie

    2012-01-01

    A sound knowledge base is required to target resources to reduce workplace exposure to carcinogens. This project aimed to provide an objective estimate of the burden of cancer in Britain due to occupation. This volume presents extensive analyses for all carcinogens and occupational circumstances defined as definite or probable human occupational carcinogens by the International Agency for Research on Cancer. This article outlines the structure of the supplement – two methodological papers (st...

  15. The burden of insomnia in Japan

    OpenAIRE

    Mishima K; DiBonaventura MD; Gross H

    2015-01-01

    Kazuo Mishima,1 Marco daCosta DiBonaventura,2 Hillary Gross2 1Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan; 2Kantar Health, New York, NY, USA Objectives: Several studies have suggested that patients who experience insomnia report a number of significant impairments. However, despite this literature, fewer studies have focused on the burden of insomnia among patients in Japan. The objective of the curre...

  16. Global Burden of Thrombosis: Epidemiologic Aspects.

    Science.gov (United States)

    Wendelboe, Aaron M; Raskob, Gary E

    2016-04-29

    Thromboembolic conditions were estimated to account for 1 in 4 deaths worldwide in 2010 and are the leading cause of mortality. Thromboembolic conditions are divided into arterial and venous thrombotic conditions. Ischemic heart disease and ischemic stroke comprise the major arterial thromboses and deep-vein thrombosis and pulmonary embolism comprise venous thromboembolism. Atrial fibrillation is a major risk factor for stroke and systemic arterial thromboembolism. Estimates of the global burden of disease were obtained from Global Burden of Disease Project reports, recent systematic reviews, and searching the published literature for recent studies reporting measures of incidence, burden, and disability-adjusted life-years. Estimates per 100 000 of the global incidence rate (IR) for each condition are ischemic heart disease, IR=1518.7; myocardial infarction, IR=139.3; ischemic stroke, IR=114.3; atrial fibrillation, IR=77.5 in males and 59.5 in females; and venous thromboembolism, IR=115 to 269. Mortality rates (MRs) for each condition are ischemic heart disease, MR=105.5; ischemic stroke, MR=42.3; atrial fibrillation, MR=1.7; and venous thromboembolism, MR=9.4 to 32.3. Global public awareness is substantially lower for pulmonary embolism (54%) and deep-vein thrombosis (44%) than heart attack (88%) and stroke (85%). Over time, the incidence and MRs of these conditions have improved in developed countries, but are increasing in developing countries. Public health efforts to measure disease burden and increase awareness of symptoms and risk factors need to improve, particularly in low- and middle-income regions to address this leading cause of morbidity and mortality. PMID:27126645

  17. The economic burden of hemodialysis in Jordan

    Directory of Open Access Journals (Sweden)

    Emad Adel Al-Shdaifat

    2013-01-01

    Full Text Available Background: Hemodialysis treatment is a costly procedure that requires specific resources. It has a considerable burden on patients, caregivers, and healthcare system. The aim of this study was to estimate the economic burden borne by the Ministry of Health (MOH in Jordan, with a focus on direct medical, direct non-medical, and indirect cost. Materials and Methods:The study was conducted at MOH hospitals in Jordan, from August to November 2010. A total of 138 patients and 49 caregivers were involved in the study. An economic evaluation study was used to analyze the burden of hemodialysis treatment at MOH, Jordan. Direct medical costs were estimated through micro and macro costing from the provider′s perspective. Patients′ and caregivers′ costs were included to calculate direct non-medical costs. Human capital approach was employed to evaluate the productivity loss for indirect cost and premature death and potential year life loss was used to estimate the premature death cost. Results: The total burden of hemodialysis at MOH, Jordan was USD17.70 million per year. Cost per session was $72 and the annual cost per patient was $9976. Direct medical cost was $7.20 million (41% and direct non-medical cost was $2.02 million (11%. On the other hand, indirect cost (productivity loss was $8.48 million (48%. All 722 patients on hemodialysis at MOH hospitals consumed 2.7% of MOH budget. Conclusions: Costs of treating and managing patients on hemodialysis at MOH hospitals in Jordan are substantial. Therefore, efforts should be taken to slow down the progress of renal failure to save resources and a comparative study with other modalities, such as continuous ambulatory peritoneal dialysis and kidney transplantation, should be considered.

  18. Understanding social support burden among family caregivers.

    Science.gov (United States)

    Wittenberg-Lyles, Elaine; Washington, Karla; Demiris, George; Oliver, Debra Parker; Shaunfield, Sara

    2014-01-01

    Despite the abundance of research on social support, both as a variable in larger studies and as a central focus of examination, there is little consensus about the relationship between social support and health outcomes. Current social support measures typically account only for frequency and size of network, and a paucity of research exists that has explained social support burden, defined as the burden associated with accessing and receiving support from others. We analyzed audio-recorded discussions by hospice family caregivers about their caregiving problems and potential solutions to examine social relationships within networks and identify the processes that influence social support seeking and receiving. Using qualitative thematic analysis, we found that caregivers providing hospice care experience social support burden resulting from perceived relational barriers between friends and family, the inclination to remain in control, recognition of the loss of the patient as a source of social support and guidance in decision making, family dynamics, and decreased availability of emotional support. Social support researchers should consider how the quality of communication and relationships within social networks impacts the provision and subsequent outcomes of social support in varying contexts. Findings from this study suggest that hospice social support resources should be tailored to the caregiver's support needs and include assessment on the type of support to be offered. PMID:24345081

  19. Tobacco and the Escalating Global Cancer Burden

    Directory of Open Access Journals (Sweden)

    Richard F. Oppeltz

    2011-01-01

    Full Text Available The global burden of cancer is escalating as a result of dramatic increases in the use of tobacco in the developing world. The use of tobacco is linked to the development of a broad variety of cancers, mainly lung cancer, the single most common cancer in the world. Tobacco smoking-attributable deaths extends beyond cancer and include stroke, heart attack and COPD. Widening disparities in cancer-related mortality have shifted towards a more dramatic burden in the developing world. Appropriate interventions must be implemented to reduce tobacco use and prevent global mortality that has escalated to epidemic levels. Tobacco control policies, including public health advertisement campaigns, warning labels, adoption of smoke-free laws, comprehensive bans and tax policies are highly effective measures to control tobacco use. Clinicians and academic institutions have to be actively committed to support tobacco control initiatives. The reduction in cancer related morbidity and mortality should be viewed as a global crisis and definitive results will depend on a multilevel effort to effectively reduce the burden of cancer, particularly in underprivileged regions of the world.

  20. Tobacco and the escalating global cancer burden.

    Science.gov (United States)

    Oppeltz, Richard F; Jatoi, Ismail

    2011-01-01

    The global burden of cancer is escalating as a result of dramatic increases in the use of tobacco in the developing world. The use of tobacco is linked to the development of a broad variety of cancers, mainly lung cancer, the single most common cancer in the world. Tobacco smoking-attributable deaths extends beyond cancer and include stroke, heart attack and COPD. Widening disparities in cancer-related mortality have shifted towards a more dramatic burden in the developing world. Appropriate interventions must be implemented to reduce tobacco use and prevent global mortality that has escalated to epidemic levels. Tobacco control policies, including public health advertisement campaigns, warning labels, adoption of smoke-free laws, comprehensive bans and tax policies are highly effective measures to control tobacco use. Clinicians and academic institutions have to be actively committed to support tobacco control initiatives. The reduction in cancer related morbidity and mortality should be viewed as a global crisis and definitive results will depend on a multilevel effort to effectively reduce the burden of cancer, particularly in underprivileged regions of the world. PMID:21869888

  1. Caregiver Burden in Epilepsy: Determinants and Impact

    Directory of Open Access Journals (Sweden)

    Ioannis Karakis

    2014-01-01

    Full Text Available Aim. Caregiver burden (CB in epilepsy constitutes an understudied area. Here we attempt to identify the magnitude of this burden, the factors associated with it, and its impact to caregiver quality of life (QOL. Methods. 48 persons with epilepsy (PWE underwent video-EEG monitoring and their caregivers completed questionnaires providing demographic, disease-related, psychiatric, cognitive, sleep, QOL, and burden information. Results. On regression analysis, higher number of antiepileptic drugs, poorer patient neuropsychological performance, lower patient QOL score, and lower caregiver education level were associated with higher CB. Time allocated to patient care approximated but did not attain statistical significance. A moderate inverse correlation between CB and caregiver QOL physical component summary score and a stronger inverse correlation between CB and caregiver QOL mental component summary score were seen. Conclusion. In a selected cohort of PWE undergoing video-EEG monitoring, we identified modest degree of CB, comparable to that reported in the literature for other chronic neurological conditions. It is associated with specific patient and caregiver characteristics and has a negative effect on caregiver QOL.

  2. Economic burden of dengue infections in India.

    Science.gov (United States)

    Garg, Pankaj; Nagpal, Jitender; Khairnar, Prakash; Seneviratne, Suranjith L

    2008-06-01

    Dengue infections are a significant cause of morbidity and mortality and lead to adverse economic effects in many developing tropical countries. In this study, we estimated the economic burden faced by India during the 2006 dengue epidemic. Costs incurred in managing a cohort of serologically confirmed dengue patients at a tertiary-level private hospital in north India were calculated. The median cost of treatment per hospitalised dengue patient was US$432.2 (95% CI US$343.6-625). A sensitivity analysis was performed to estimate the costs to the health system in India using a regression model. Variables with potentially large variations, including the ratio of unreported to reported cases and of hospitalised to ambulatory cases, the proportion requiring transfusions, loss of economic activities due to loss of workdays and deaths, were used. The average total economic burden was estimated to be US$27.4 million (95% CI US$25.7-29.1 million). Costs in the private heath sector were estimated to be almost four times public sector expenditures. Considerable economic losses (at a macro level) are incurred by developing countries like India during each dengue epidemic. Accurate estimates of the proportions of reported to unreported and of hospitalised to ambulatory dengue cases in India are needed to refine further the estimates of financial burden due to dengue in India. PMID:18402995

  3. The Tax Burden on Tobacco Volume 49, 1970-2014

    Data.gov (United States)

    U.S. Department of Health & Human Services — 1970-2014. Orzechowski and Walker. Tax Burden on Tobacco. Tax burden data was obtained from the annual compendium on tobacco revenue and industry statistics, The...

  4. Policy Burdens, Accountability and Soft Budget Constraint of Chinese HEIs

    Science.gov (United States)

    Yu, Jianhai

    2008-01-01

    Policy burdens of HEIs (higher education institutions) lead to the soft budget constraint (SBC) and the excessive loans of HEIs. Since information asymmetry and incentive are incompatible, policy burdens will result in the adverse selection of the president, and the excessive loans and low efficiency of HEIs. When HEIs are with policy burdens, the…

  5. Socioeconomic differences in the burden of disease in Sweden

    DEFF Research Database (Denmark)

    Ljung, Rickard; Peterson, Stefan; Hallqvist, Johan;

    2005-01-01

    disease were analysed using attributable fractions and the slope index of inequality and the relative index of inequality. FINDINGS: About 30% of the burden of disease among women and 37% of the burden among men is a differential burden resulting from socioeconomic inequalities in health. A large part of...

  6. 43 CFR 4.1366 - Burdens of proof.

    Science.gov (United States)

    2010-10-01

    ... review, OSMRE shall have the burden of going forward to establish a prima facie case as to failure to... person is seeking review, that person shall have the burden of going forward to establish a prima facie... ordered by OSMRE, OSMRE shall have the burden of going forward to establish a prima facie case that...

  7. The Mood Disorder Burden Index: A Scale for Assessing the Burden of Caregivers to Adults with Unipolar or Bipolar Disorder

    OpenAIRE

    Martire, Lynn M.; Hinrichsen, Gregory A.; Morse, Jennifer Q.; Reynolds, Charles F.; Gildengers, Ariel G.; Mulsant, Benoit H.; Schulz, Richard

    2009-01-01

    In this paper we present a brief measure of caregiver burden, the Mood Disorder Burden Index (MDBI), for use with family members and close friends of adults with major depressive disorder (MDD) or bipolar disorder (BD). The MDBI assesses burden in three core domains (patients’ mood symptoms, caregivers’ worry about the future, and caregivers’ interpersonal difficulties with the patient) and includes an optional module that assesses caregiver burden associated with patients’ pharmacotherapy or...

  8. Epidemiology and burden of nasal congestion

    Directory of Open Access Journals (Sweden)

    Michael Stewart

    2010-02-01

    Full Text Available Michael Stewart1, BJ Ferguson2, Len Fromer31Department of Otorhinolaryngology, Weill Cornell Medical College, New York-Presbyterian Hospital/Weill Cornell Medical Center, USA; 2Department of Otolaryngology, University of Pittsburgh School of Medicine, USA; 3University of California, Los Angeles; David Geffen School of Medicine Los Angeles, California, USAAbstract: Nasal congestion, which may be described as fullness, obstruction, reduced airflow, or being “stuffed up,” is a commonly encountered symptom in clinical practice. Systematic study of congestion has largely considered it as a component of a disease state. Conditions associated with congestion include nasal polyposis, obstructive sleep apnea, and anatomic variation; however, most information on the burden of congestion comes from studies of allergic rhinitis and rhinosinusitis, diseases of which congestion is the major symptom. Congestion can be caused by other rhinologic conditions, such as non-allergic rhinitis, viral or bacterial rhinitis, and vasomotor rhinitis. Allergic rhinitis affects as much as one quarter of the population worldwide and imposes a significant economic burden. Additionally, allergic rhinitis significantly impairs quality of life; congestion causes allergic rhinitis sufferers decreased daytime productivity at work or school and reduces night-time sleep time and quality. Annually, rhinosinusitis affects tens of millions of Americans and leads to approximately $6 billion in overall health care expenditures; it has been found to be one of the most costly physical conditions for US employers. Given the high prevalence and significant social and economic burden of nasal congestion, this symptom should be a key consideration in treating patients with rhinologic disease, and there continues to be a significant unmet medical need for effective treatment options for this condition.Keywords: allergic rhinitis, congestion, epidemiology, obstruction, rhinosinusitis

  9. National Burden of Eye Diseases in Iran, 1990–2010; findings from the global burden of diseases study 2010

    Directory of Open Access Journals (Sweden)

    Elham Hatef

    2016-01-01

    Conclusions: Epidemiologic transition is reflected in major ophthalmic and blinding diseases in the GBD data for Iran. The burden of macular degeneration is rising, followed by glaucoma. The burden of presbyopia affected individuals past their middle age. The burden of cataract manifested as a slower increase that could be attributable to better access to treatment.

  10. Whole body monitoring - Goiania

    International Nuclear Information System (INIS)

    Due to the radiological Cs accident in Goiania, Goias in September 1987, it became necessary to evaluate internal contamination levels of: - Individual from the general public that for any reason had direct or indirect involvement with the radioactive source (group 1). - Occupationally involved persons (group 2). For each of these groups, procedures of whole body monitoring were developped. In order to attend group 1 individuals, the IRD/CNEN installed a whole body unit in the INAMPS General Hospital of Goiania in 11.08.87, which was later transferred to 121,57 street, Central Sector in Goiania in 2.06.88. In this unit 547 people were monitored, 356 from group 1 and 241 from group 2, until 04.13.88. In the IRD whole body counter installation, 194 individuals were counted, 185 from group 2 and 9 from group 1. The frequency of monitoring of each individual was established according to the Cs activity present in the body or to the job to be assigned. In this paper we will present some burden activity curves for Cs 137 as a function of the time elapsed from the first measurement. There people from group 1 were measured in both counters, the IRD and the Goiania ones. The values obtained in both installations are compatible with the body activity x time curve. (author)

  11. Global Economic Burden of Norovirus Gastroenteritis.

    Directory of Open Access Journals (Sweden)

    Sarah M Bartsch

    Full Text Available Despite accounting for approximately one fifth of all acute gastroenteritis illnesses, norovirus has received comparatively less attention than other infectious pathogens. With several candidate vaccines under development, characterizing the global economic burden of norovirus could help funders, policy makers, public health officials, and product developers determine how much attention and resources to allocate to advancing these technologies to prevent and control norovirus.We developed a computational simulation model to estimate the economic burden of norovirus in every country/area (233 total stratified by WHO region and globally, from the health system and societal perspectives. We considered direct costs of illness (e.g., clinic visits and hospitalization and productivity losses.Globally, norovirus resulted in a total of $4.2 billion (95% UI: $3.2-5.7 billion in direct health system costs and $60.3 billion (95% UI: $44.4-83.4 billion in societal costs per year. Disease amongst children <5 years cost society $39.8 billion, compared to $20.4 billion for all other age groups combined. Costs per norovirus illness varied by both region and age and was highest among adults ≥55 years. Productivity losses represented 84-99% of total costs varying by region. While low and middle income countries and high income countries had similar disease incidence (10,148 vs. 9,935 illness per 100,000 persons, high income countries generated 62% of global health system costs. In sensitivity analysis, the probability of hospitalization had the largest impact on health system cost estimates ($2.8 billion globally, assuming no hospitalization costs, while the probability of missing productive days had the largest impact on societal cost estimates ($35.9 billion globally, with a 25% probability of missing productive days.The total economic burden is greatest in young children but the highest cost per illness is among older age groups in some regions. These large

  12. The burden of disease and injury in Australia.

    Science.gov (United States)

    Mathers, C D; Vos, E T; Stevenson, C E; Begg, S J

    2001-01-01

    An overview of the results of the Australian Burden of Disease (ABD) study is presented. The ABD study was the first to use methodology developed for the Global Burden of Disease study to measure the burden of disease and injury in a developed country. In 1996, mental disorders were the main causes of disability burden, responsible for nearly 30% of total years of life lost to disability (YLD), with depression accounting for 8% of the total YLD. Ischaemic heart disease and stroke were the main contributors to the disease burden disability-adjusted life years (DALYs), together causing nearly 18% of the total disease burden. Risk factors such as smoking, alcohol consumption, physical inactivity, hypertension, high blood cholesterol, obesity and inadequate fruit and vegetable consumption were responsible for much of the overall disease burden in Australia. The lessons learnt from the ABD study are discussed, together with methodological issues that require further attention. PMID:11731817

  13. Discourse and Review of Environmental Quality of River Bodies in India: An Appraisal of Physico-chemical and Biological Parameters as Indicators of Water Quality

    OpenAIRE

    Kumar Manoj; Pratap Kumar Padhy

    2015-01-01

    The present manuscript is an account of the studies conducted on some well known surface water bodies in India, with special emphasis on the river systems, to evaluate their quality status. The review covers the water quality estimation and identification of sources contributing to water quality deterioration. Commonly employed physicochemical and biological parameters as indicators of water quality have been thoroughly discussed. Some possible measures to prevent and control pollution of wat...

  14. Plastic ingestion by Flesh-footed Shearwaters (Puffinus carneipes): Implications for fledgling body condition and the accumulation of plastic-derived chemicals

    International Nuclear Information System (INIS)

    To provide much needed quantitative data on the lethal and sublethal effects of plastic pollution on marine wildlife, we sampled breast feathers and stomach contents from Flesh-footed Shearwater (Puffinus carneipes) fledglings in eastern Australia. Birds with high levels of ingested plastic exhibited reduced body condition and increased contaminant load (p < 0.05). More than 60% of fledglings exceed international targets for plastic ingestion by seabirds, with 16% of fledglings failing these targets after a single feeding (range: 0.13–3.21 g of plastic/feeding). As top predators, seabirds are considered sentinels of the marine environment. The amount of plastic ingested and corresponding damage to Flesh-footed Shearwater fledglings is the highest reported for any marine vertebrate, suggesting the condition of the Australian marine environment is poor. These findings help explain the ongoing decline of this species and are worrying in light of increasing levels of plastic pollution in our oceans. - Highlights: • Proportion of the shearwater population ingesting plastic increased over four years. • Shearwater body condition is negatively influenced by the amount of ingested plastic. • Shearwater contaminant load is positively related to the amount of ingested plastic. • Many chicks exceed international targets for ingested plastic after a single feeding. • Plastic ingestion in this study is the highest reported for any marine vertebrate. - Flesh-footed Shearwaters ingest large quantities of marine plastic, which is correlated with poor body condition and increased concentrations of trace metals such as chromium

  15. The Burden of Asthma in Oman

    Directory of Open Access Journals (Sweden)

    Nasser Al-Busaidi

    2015-05-01

    Full Text Available Asthma is a common lung disease worldwide, although its prevalence varies from country to country. Oman is ranked in the intermediate range based on results from the International Study of Asthma and Allergies in Childhood. A 2009 study revealed that the majority of asthmatic patients in Oman reported both daytime and nocturnal symptoms, while 30% of adults and 52% of children reported absences from work or school due to their symptoms. Despite these findings, there is little data available on the economic burden of asthma in Oman. The only accessible information is from a 2013 study which concluded that Oman’s highest asthma-related costs were attributable to inpatient (55% and emergency room (25% visits, while asthma medications contributed to less than 1% of the financial toll. These results indicate a low level of asthma control in Oman, placing a large economic burden on healthcare providers. Therefore, educating asthmatic patients and their families should be prioritised in order to improve the management and related costs of this disease within Oman.

  16. Economic burden of blindness in India

    Directory of Open Access Journals (Sweden)

    Shamanna B

    1998-01-01

    Full Text Available Economic analysis is one way to determine the allocation of scarce resources for health-care programs. The initial step in this process is to estimate in economic terms the burden of diseases and the benefit from interventions for prevention and treatment of these diseases. In this paper, the direct and indirect economic loss due to blindness in India is calculated on the basis of certain assumptions. The cost of treating cataract blindness in India is estimated at current prices. The economic burden of blindness in India for the year 1997 based on our assumptions is Rs. 159 billion (US$ 4.4 billion, and the cumulative loss over lifetime of the blind is Rs. 2,787 billion (US$ 77.4 billion. Childhood blindness accounts for 28.7% of this lifetime loss. The cost of treating all cases of cataract blindness in India is Rs. 5.3 billion (US$ 0.15 billion. Similar estimates for causes of blindness other than cataract have to be made in order to develop a comprehensive approach to deal with blindness in India.

  17. Chinese Caregiving Burden and the Future Burden of Elder Care in Life-Course Perspective

    Science.gov (United States)

    Zhan, Heying Jenny

    2002-01-01

    This article uses the life course perspective to combine micro- and macro-levels of analysis of caregiving burdens experienced by Chinese baby-boom cohort and then explores their elder care prospects. Based on survey interviews during 1997 and 1998 with 110 caregivers providing care to dependent parents or parents-in-law, this study finds that…

  18. The Burden of Social Security Taxes and the Burden of Excessive Health Care Costs

    OpenAIRE

    Dean Baker; David Rosnick

    2005-01-01

    This report shows that the burden of excessive health care cost growth (defined as cost growth in excess of economic growth and the impact of aging) over the years 1980 to 2004 was almost 7 times as large as the tax increase that the Social Security trustees project will be needed to keep Social Security fully solvent over its 75-year planning horizon.

  19. NIH disease funding levels and burden of disease.

    Directory of Open Access Journals (Sweden)

    Leslie A Gillum

    Full Text Available BACKGROUND: An analysis of NIH funding in 1996 found that the strongest predictor of funding, disability-adjusted life-years (DALYs, explained only 39% of the variance in funding. In 1998, Congress requested that the Institute of Medicine (IOM evaluate priority-setting criteria for NIH funding; the IOM recommended greater consideration of disease burden. We examined whether the association between current burden and funding has changed since that time. METHODS: We analyzed public data on 2006 NIH funding for 29 common conditions. Measures of US disease burden in 2004 were obtained from the World Health Organization's Global Burden of Disease study and national databases. We assessed the relationship between disease burden and NIH funding dollars in univariate and multivariable log-linear models that evaluated all measures of disease burden. Sensitivity analyses examined associations with future US burden, current and future measures of world disease burden, and a newly standardized NIH accounting method. RESULTS: In univariate and multivariable analyses, disease-specific NIH funding levels increased with burden of disease measured in DALYs (p = 0.001, which accounted for 33% of funding level variation. No other factor predicted funding in multivariable models. Conditions receiving the most funding greater than expected based on disease burden were AIDS ($2474 M, diabetes mellitus ($390 M, and perinatal conditions ($297 M. Depression ($719 M, injuries ($691 M, and chronic obstructive pulmonary disease ($613 M were the most underfunded. Results were similar using estimates of future US burden, current and future world disease burden, and alternate NIH accounting methods. CONCLUSIONS: Current levels of NIH disease-specific research funding correlate modestly with US disease burden, and correlation has not improved in the last decade.

  20. The Psychological Burden of Skin Diseases

    DEFF Research Database (Denmark)

    Dalgard, Florence J; Gieler, Uwe; Tomas-Aragones, Lucia;

    2015-01-01

    The contribution of psychological disorders to the burden of skin disease has been poorly explored, and this is a large-scale study to ascertain the association between depression, anxiety, and suicidal ideation with various dermatological diagnoses. This international multicenter observational...... cross-sectional study was conducted in 13 European countries. In each dermatology clinic, 250 consecutive adult out-patients were recruited to complete a questionnaire, reporting socio-demographic information, negative life events, and suicidal ideation; depression and anxiety were assessed with the...... Hospital Anxiety and Depression Scale. A clinical examination was performed. A control group was recruited among hospital employees. There were 4,994 participants--3,635 patients and 1,359 controls. Clinical depression was present in 10.1% patients (controls 4.3%, odds ratio (OR) 2.40 (1...

  1. RRG: Should certification outrank burden-cutting?

    International Nuclear Information System (INIS)

    This article reports on the recommendations from the Regulatory Review Group (RRG) of the Nuclear Regulatory Commission released on August 20. The general thrust of the report is that the RRG considers the technical substance of the agency's regulations to be either acceptable or under an appropriate review process, but believes that licensees are improperly burdened by arbitrary or vague 'commitments,' decreed by NRC personnel and not clearly based on regulations. The RRG report stated a belief 'that fundamental change can be achieved and maintained only through rulemaking which unambiguously sets the standards to be pursued by both the staff and the industry. If the performance objectives of the regulations are deficient they should be changed and subject to the Backfit Rule. This recommendation is so dominant in effecting change that the Review Group has included as Appendix A a commission paper and proposed rule.'

  2. Reviewing disease burden among rural Indian women

    Directory of Open Access Journals (Sweden)

    Ramanakumar AV

    2004-08-01

    Full Text Available The disease burden of rural Indian women is reviewed by utilizing the data from the 'Survey of Causes of Death (rural' annual reports of Registrar General of India supplemented with National family health survey (NFHS-II. The review indicates that bronchitis and asthma are the leading causes while prematurity and heart attacks are second and third respectively. Most of the maternal deaths are concentrated in the age group 20-24 and bleeding is the main cause of maternal death. Tuberculosis of the lungs, malaria and burns are also important causes of death in the early reproductive ages. Rate of suicide, burn, and anaemia diminishes with age. Though nationwide health plans have succeeded in reducing the fatality of women's diseases to a entrain extent, there is however, a great need for improved and effective area-specific health programs to achieve the desired goals.

  3. Economic burden of cervical cancer in Malaysia

    Directory of Open Access Journals (Sweden)

    Sharifa E.W. Puteh

    2008-12-01

    Full Text Available Cervical cancers form the second highest number of female cancers in Malaysia, imposing a substantial amount of cost burden on its management. However, an estimation of cost burden of abnormal smears, cervical pre-invasive and invasive diseases needs to be done to show how much spending has been allocated to the problem. An expert panel committee came up with the clinical pathway and management algorithm of  cervical pre invasive and invasive diseases from July-December 2006 Malaysia. An activity based costing for each clinical pathway was done. Results were converted to USD. The cost of managing pre-invasive cervical cancers stage is USD 420,150 (Range: USD 197,158-879,679. Management of invasive cancer (new cases costs USD 51,533,233.44 (Range: USD 32,405,399.69 - USD 129,014,768.40. The cost of managing existing cases is USD 17,005,966.87 (Range: USD 10,693,781.90 - USD  28,901,587.12. The total cost of managing cervical cancers by health care providers in a public setting is around USD 75,888,329.45 (Range: USD 48,083,804.60 - USD 48,083,804.60. The outcome of this study has shown that preventive modalities such as screening have only contributed to 10.3 % of the total management cost of cervical cancer. The major cost contribution (67% came from treatment of invasive cancer especially at more advanced stages of cancer, followed by treatment of existing cases (22% and lastly on pre-invasive disease (0.6%. This study revealed that proportion of preventive modality in this country was still low, and the major cost came from actual treatment cost of cervical cancer. Therefore, heightened public cervical cancer screening in the country is needed. (Med J Indones 2008; 17: 272-80Keywords: cervical cancers, pre invasive disease, HPV vaccination

  4. Perception of burden by caregivers of patients with schizophrenia

    OpenAIRE

    Srivastava, Sunil

    2005-01-01

    Background: There is a dearth of studies assessing the burden of caregivers of patients with schizophrenia and illness-related variables such as age, sex, duration of illness, domicile, martial status, education, employment and previous hospitalization. Aim: The study was conducted to measure the perception of burden by caregivers of patients with schizophrenia and its correlation with nine factors on the Burden Assessment Schedule (BAS) related to spouse, physical and mental health, external...

  5. Health beliefs and carer burden in first episode psychosis

    OpenAIRE

    Patel, Maya; Chawla, Rajan; Krynicki, Carl R; Rankin, Philip; Upthegrove, Rachel

    2014-01-01

    Background Carer burden is high during First Episode Psychosis (FEP) and evidence suggests that this is a predictor of poor long-term outcome. However our understanding of factors associated with higher burden is poor. We propose that carers’ cultural backgrounds and health belief models will influence their perceived burden of care, over and above that explained by severity of illness. Methods Patients with FEP and their primary Carers were recruited from the Early Intervention Service. Pati...

  6. The Global Burden of Musculoskeletal Injuries: Challenges and Solutions

    OpenAIRE

    Mock, Charles; Cherian, Meena Nathan

    2008-01-01

    Musculoskeletal injuries are a major public health problem globally, contributing a large burden of disability and suffering. This burden could be considerably lowered by implementation of affordable and sustainable strategies to strengthen orthopaedic trauma care, especially in low- and middle-income countries. This article summarizes the global burden of musculoskeletal injuries and provides several examples of successful programs that have improved care of injuries in health facilities in ...

  7. CAREGIVER'S BURDEN : A COMPARISON BETWEEN OBSESSIVE COMPULSIVE DISORDER AND SCHIZOPHRENIA

    OpenAIRE

    C.Jayakumar; Jagadheesan, K.; A N Verma

    2002-01-01

    The present study compared burden of care between the key relatives of patients with obsessive compulsive disorder (OCD) and schizophrenia. For this study, consecutive key relatives of patients with either OCD (n=30) or schizophrenia (n=41) were evaluated with 40-item burden assessment schedule (BAS). In comparison with schizophrenia group, caregivers in OCD group had significantly high mean scores for the domains, spouse-related factor and caregiver's strategy of BAS. The degree of burden, e...

  8. Overview of the Burden of Diseases in North Korea

    OpenAIRE

    Lee, Yo Han; Yoon, Seok-Jun; Kim, Young Ae; Yeom, Ji Won; Oh, In-Hwan

    2013-01-01

    This article evaluates the overall current disease burden of North Korea through the recent databases of international organizations. It is notable that North Korea as a nation is exhibiting a relatively low burden from deaths and that there is greater burden from deaths caused by non-communicable diseases than from those caused by communicable diseases and malnutrition. However, the absolute magnitude of problems from communicable diseases like TB and from child malnutrition, which will incr...

  9. More accurate picture of human body organs

    International Nuclear Information System (INIS)

    Computerized tomography and nucler magnetic resonance tomography (NMRT) are revolutionary contributions to radiodiagnosis because they allow to obtain a more accurate image of human body organs. The principles are described of both methods. Attention is mainly devoted to NMRT which has clinically only been used for three years. It does not burden the organism with ionizing radiation. (Ha)

  10. Body integrity identity disorder.

    Directory of Open Access Journals (Sweden)

    Rianne M Blom

    Full Text Available INTRODUCTION: Body Integrity Identity Disorder (BIID is a rare, infrequently studied and highly secretive condition in which there is a mismatch between the mental body image and the physical body. Subjects suffering from BIID have an intense desire to amputate a major limb or severe the spinal cord in order to become paralyzed. Aim of the study is to broaden the knowledge of BIID amongst medical professionals, by describing all who deal with BIID. METHODS: Somatic, psychiatric and BIID characteristic data were collected from 54 BIID individuals using a detailed questionnaire. Subsequently, data of different subtypes of BIID (i.e. wish for amputation or paralyzation were evaluated. Finally, disruption in work, social and family life due to BIID in subjects with and without amputation were compared. RESULTS: Based on the subjects' reports we found that BIID has an onset in early childhood. The main rationale given for their desire for body modification is to feel complete or to feel satisfied inside. Somatic and severe psychiatric co-morbidity is unusual, but depressive symptoms and mood disorders can be present, possibly secondary to the enormous distress BIID puts upon a person. Amputation and paralyzation variant do not differ in any clinical variable. Surgery is found helpful in all subjects who underwent amputation and those subjects score significantly lower on a disability scale than BIID subjects without body modification. CONCLUSIONS: The amputation variant and paralyzation variant of BIID are to be considered as one of the same condition. Amputation of the healthy body part appears to result in remission of BIID and an impressive improvement of quality of life. Knowledge of and respect for the desires of BIID individuals are the first steps in providing care and may decrease the huge burden they experience.

  11. Body Odor

    Science.gov (United States)

    ... Health Medical Conditions Nutrition & Fitness Emotional Health Body Odor Posted under Health Guides . Updated 29 October 2014. + ... guy has to deal with. What causes body odor? During puberty, your sweat glands become much more ...

  12. Body Hygiene

    Science.gov (United States)

    ... Home Diaper-Changing Steps for Childcare Settings Body Hygiene Dental Hygiene Water Fluoridation Facial Cleanliness Fish Pedicures and ... spread of hygiene-related diseases . Topics for Body Hygiene Facial Cleanliness Dental Hygiene Water Fluoridation Fish Pedicures and Fish Spas ...

  13. Body Image

    Science.gov (United States)

    ... Help your child have a healthy body image Cosmetic surgery Breast surgery Botox Liposuction Varicose or spider veins Body dysmorphic disorder (BDD) Eating disorders Anorexia nervosa Binge eating ... nervosa Cosmetics and your health Depression during and after pregnancy ...

  14. Body Basics

    Science.gov (United States)

    ... about how the body works, what basic human anatomy is, and what happens when parts of the body don't function properly. Blood Bones, Muscles, and Joints Brain and Nervous System Digestive System Endocrine System Eyes Female Reproductive System ...

  15. The economic burden of angina on households in South Asia

    OpenAIRE

    Alam, Khurshid; Mahal, Ajay

    2014-01-01

    Background Globally, an estimated 54 million people have angina, 16 million of whom are from the WHO South-East Asia region. Despite the increasing burden of cardiovascular disease (CVD) in South Asia, there is no evidence of an economic burden of angina on households in this region. We investigated the economic burden of angina on households in South Asia. Methods We applied a novel propensity score matching approach to assess the economic burden of angina on household out-of-pocket (OOP) he...

  16. The Importance of In Situ Measurements and Sample Return in the Search for Chemical Biosignatures on Mars or other Solar System Bodies (Invited)

    Science.gov (United States)

    Glavin, D. P.; Brinckerhoff, W. B.; Conrad, P. G.; Dworkin, J. P.; Eigenbrode, J. L.; Getty, S.; Mahaffy, P. R.

    2013-12-01

    The search for evidence of life on Mars and elsewhere will continue to be one of the primary goals of NASA's robotic exploration program for decades to come. NASA and ESA are currently planning a series of robotic missions to Mars with the goal of understanding its climate, resources, and potential for harboring past or present life. One key goal will be the search for chemical biomarkers including organic compounds important in life on Earth and their geological forms. These compounds include amino acids, the monomer building blocks of proteins and enzymes, nucleobases and sugars which form the backbone of DNA and RNA, and lipids, the structural components of cell membranes. Many of these organic compounds can also be formed abiotically as demonstrated by their prevalence in carbonaceous meteorites [1], though, their molecular characteristics may distinguish a biological source [2]. It is possible that in situ instruments may reveal such characteristics, however, return of the right samples to Earth (i.e. samples containing chemical biosignatures or having a high probability of biosignature preservation) would enable more intensive laboratory studies using a broad array of powerful instrumentation for bulk characterization, molecular detection, isotopic and enantiomeric compositions, and spatially resolved chemistry that may be required for confirmation of extant or extinct life on Mars or elsewhere. In this presentation we will review the current in situ analytical capabilities and strategies for the detection of organics on the Mars Science Laboratory (MSL) rover using the Sample Analysis at Mars (SAM) instrument suite [3] and discuss how both future advanced in situ instrumentation [4] and laboratory measurements of samples returned from Mars and other targets of astrobiological interest including the icy moons of Jupiter and Saturn will help advance our understanding of chemical biosignatures in the Solar System. References: [1] Cronin, J. R and Chang S. (1993

  17. Body embellishment

    OpenAIRE

    Zellweger, Christoph

    2015-01-01

    The exhibition Body Embellishment explores the most innovative artistic expression in the 21st-century international arenas of body extension, augmentation, and modification, focusing on jewelry, tattoos, nail arts, and fashion. The areas of focus are jewelry, tattoos, nail arts, and fashion. Avant-garde jewelry consciously engages the body by intersecting and expanding the planes of the human form. Tattoos are at once on and in the body. Nail art, from manicures to pedicures, has humble ...

  18. Body Clock

    Institute of Scientific and Technical Information of China (English)

    刘洪毓

    2000-01-01

    Body clocks” are biological methods of controling body activities.Every living thing has one. In humans, a body clock controls normal periods of sleeping and waking. It controls the time swhen you are most likely to feel pain.Eating, sleeping and exercising at about the same time each day will help keep body activities normal. But changes in your life, a new job, for example, destroy the balance and thus cause health problems.

  19. Measuring the burden of neglected tropical diseases: the global burden of disease framework.

    Directory of Open Access Journals (Sweden)

    Colin D Mathers

    Full Text Available Reliable, comparable information about the main causes of disease and injury in populations, and how these are changing, is a critical input for debates about priorities in the health sector. Traditional sources of information about the descriptive epidemiology of diseases, injuries, and risk factors are generally incomplete, fragmented, and of uncertain reliability and comparability. The Global Burden of Disease (GBD study has provided a conceptual and methodological framework to quantify and compare the health of populations using a summary measure of both mortality and disability, the disability-adjusted life year (DALY.This paper describes key features of the Global Burden of Disease analytic approach, which provides a standardized measurement framework to permit comparisons across diseases and injuries, as well as risk factors, and a systematic approach to the evaluation of data. The paper describes the evolution of the GBD, starting from the first study for the year 1990, summarizes the methodological improvements incorporated into GBD revisions for the years 2000-2004 carried out by the World Health Organization, and examines priorities and issues for the next major GBD study, funded by the Bill & Melinda Gates Foundation, and commencing in 2007.The paper presents an overview of summary results from the Global Burden of Disease study 2002, with a particular focus on the neglected tropical diseases, and also an overview of the comparative risk assessment for 26 global risk factors. Taken together, trypanosomiasis, Chagas disease, schistosomiasis, leishmaniasis, lymphatic filariasis, onchocerciasis, intestinal nematode infections, Japanese encephalitis, dengue, and leprosy accounted for an estimated 177,000 deaths worldwide in 2002, mostly in sub-Saharan Africa, and about 20 million DALYs, or 1.3% of the global burden of disease and injuries. Further research is currently underway to revise and update these estimates.

  20. Chemical composition and nutritional and medicinal value of fruit bodies and submerged cultured mycelia of culinary-medicinal higher Basidiomycetes mushrooms.

    Science.gov (United States)

    Cohen, Nachshol; Cohen, Jacob; Asatiani, Mikheil D; Varshney, Vinay K; Yu, Hui-Tzu; Yang, Yi-Chi; Li, Yu-Hsuan; Mau, Jeng-Leun; Wasser, Solomon P

    2014-01-01

    This research gives the results of a proximate analysis (moisture, ash, crude protein, fat, total carbohydrates, and total energy); a bioactive compounds analysis (γ-aminobutyric acid [GABA], ergothioneine, lovastatin, and cordycepin); fatty acid and amino acid analysis; and an analysis of macro- and microelement content of fruit bodies and mycelia of 15 higher Basidiomycetes medicinal mushroom strains belonging to 12 species. The results obtained demonstrate that almost all investigated mushrooms were found to be good sources of proteins and carbohydrates, with content varying in the ranges of 8.6-42.5% and 42.9-83.6%, respectively. Different species exhibited distinct free amino acid profiles. The total amino acid content was highest in Ophiocordyceps sinensis (MB) (23.84 mg/g) and Cordyceps militaris (FB) (23.69 mg/g). The quantification of the identified fatty acids indicated that, in general, palmitic acid, oleic acid, stearic acid, and linoleic acid were the major fatty acids. The micro- and macroelement compositions were studied, and the highest results were (as milligrams per kilogram) 224-7307 for calcium, 1668-38564 for potassium, 1091-11676 for phosphorus, and 5-97 for zinc. Bioactive components were lovastatin, GABA, and ergothioneine, which are commonly found in most mushrooms. C. militaris (FB), Pleurotus ostreatus (FB), and Coprinus comatus (FB) were most abundant and contained a high amount of GABA (756.30 μg/g, 1304.99 μg/g, 1092.45 μg/g, respectively) and ergothioneine (409.88 μg/g, 2443.53 μg/g, 764.35 μg/g, respectively). The highest lovastatin content was observed in Hericium erinaceus (FB) (14.38 μg/g) and Ganoderma lucidum (FB) (11.54 μg/g). In contrast to C. militaris (FB), cordycepin was not detected in O. sinensis (MB). The fruit body biomass of C. militaris cordycepin content reached 1.743 mg/g dry weight. The nutritional values of the mushroom species studied here could potentially be used in well-balanced diets and as sources

  1. The burden of spousal caregiving: A preliminary psychometric evaluation of the German version of the Zarit Burden Interview

    OpenAIRE

    Braun, M.; Scholz, Urte; Hornung, Rainer; Martin, Mike

    2010-01-01

    Objectives: Despite a rapid increase in studies dealing with dementia caregivers in Europe, a valid German version of the most widely used measurement of caregiver burden (Zarit Burden Interview) has not yet been published. The purpose of this study is to evaluate the psychometric properties of the German Zarit Burden Interview (G-ZBI). Method: Twenty-eight community-dwelling older couples with the husband suffering from dementia and the wife being the primary caregiver participated in th...

  2. Pulmonary impairment after tuberculosis and its contribution to TB burden

    Directory of Open Access Journals (Sweden)

    Munguia Guadalupe

    2010-05-01

    Full Text Available Abstract Background The health impacts of pulmonary impairment after tuberculosis (TB treatment have not been included in assessments of TB burden. Therefore, previous global and national TB burden estimates do not reflect the full consequences of surviving TB. We assessed the burden of TB including pulmonary impairment after tuberculosis in Tarrant County, Texas using Disability-adjusted Life Years (DALYs. Methods TB burden was calculated for all culture-confirmed TB patients treated at Tarrant County Public Health between January 2005 and December 2006 using identical methods and life tables as the Global Burden of Disease Study. Years of life-lost were calculated as the difference between life expectancy using standardized life tables and age-at-death from TB. Years lived-with-disability were calculated from age and gender-specific TB disease incidence using published disability weights. Non-fatal health impacts of TB were divided into years lived-with-disability-acute and years lived-with-disability-chronic. Years lived-with-disability-acute was defined as TB burden resulting from illness prior to completion of treatment including the burden from treatment-related side effects. Years lived-with-disability-chronic was defined as TB burden from disability resulting from pulmonary impairment after tuberculosis. Results There were 224 TB cases in the time period, of these 177 were culture confirmed. These 177 subjects lost a total of 1189 DALYs. Of these 1189 DALYs 23% were from years of life-lost, 2% were from years lived-with-disability-acute and 75% were from years lived-with-disability-chronic. Conclusions Our findings demonstrate that the disease burden from TB is greater than previously estimated. Pulmonary impairment after tuberculosis was responsible for the majority of the burden. These data demonstrate that successful TB control efforts may reduce the health burden more than previously recognized.

  3. Emergent of Burden Sharing of Robots with Emotion Model

    Science.gov (United States)

    Kusano, Takuya; Nozawa, Akio; Ide, Hideto

    Cooperated multi robots system has much dominance in comparison with single robot system. Multi robots system is able to adapt to various circumstances and has a flexibility for variation of tasks. Robots are necessary that build a cooperative relations and acts as an organization to attain a purpose in multi robots system. Then, group behavior of insects which doesn't have advanced ability is observed. For example, ants called a sociality insect emerge systematic activities by the interaction with using a very simple way. Though ants make a communication with chemical matter, a human plans a communication by words and gestures. In this paper, we paid attention to the interaction based on psychological viewpoint. And a human's emotion model was used for the parameter which became a base of the motion planning of robots. These robots were made to do both-way action in test field with obstacle. As a result, a burden sharing like guide or carrier was seen even though those had a simple setup.

  4. Burden of disease of dietary exposure to acrylamide in Denmark.

    Science.gov (United States)

    Jakobsen, Lea Sletting; Granby, Kit; Knudsen, Vibeke Kildegaard; Nauta, Maarten; Pires, Sara Monteiro; Poulsen, Morten

    2016-04-01

    Acrylamide (AA) is a process-contaminant that potentially increases the risk of developing cancer in humans. AA is formed during heat treatment of starchy foods and detected in a wide range of commonly consumed products. Increased focus on risk ranking and prioritization of major causes of disease makes it relevant to estimate the impact that exposure to chemical contaminants and other hazards in food have on health. In this study, we estimated the burden of disease (BoD) caused by dietary exposure to AA, using disability adjusted life years (DALY) as health metric. We applied an exposure-based approach and proposed a model of three components: an exposure, health-outcome, and DALY-module. We estimated BoD using two approaches for estimating cancer risk based on toxicological data and two approaches for estimating DALY. In Denmark, 1.8 healthy life years per 100.000 inhabitants are lost each year due to exposure to AA through foods, as estimated by the most conservative approach. This result should be used to inform risk management decisions and for comparison with BoD of other food-borne hazards for prioritizing policies. However, our study shows that careful evaluation of methodological choices and assumptions used in BoD studies is necessary before use in policy making. PMID:26845613

  5. Tumor burden talks in cancer treatment with PEGylated liposomal drugs.

    Directory of Open Access Journals (Sweden)

    Yi-Yu Lin

    Full Text Available PURPOSE: PEGylated liposomes are important drug carriers that can passively target tumor by enhanced permeability and retention (EPR effect in neoplasm lesions. This study demonstrated that tumor burden determines the tumor uptake, and also the tumor response, in cancer treatment with PEGylated liposomal drugs in a C26/tk-luc colon carcinoma-bearing mouse model. METHODS: Empty PEGylated liposomes (NanoX and those encapsulated with VNB (NanoVNB were labeled with In-111 to obtain InNanoX and InVNBL in high labeling yield and radiochemical purity (all >90%. BALB/c mice bearing either small (58.4±8.0 mm(3 or large (102.4±22.0 mm(3 C26/tk-luc tumors in the right dorsal flank were intravenously administered with NanoVNB, InNanoX, InVNBL, or NanoX as a control, every 7 days for 3 times. The therapeutic efficacy was evaluated by body weight loss, tumor growth inhibition (using calipers and bioluminescence imaging and survival fraction. The scintigraphic imaging of tumor mouse was performed during and after treatment. RESULTS: The biodistribution study of InVNBL revealed a clear inverse correlation (r (2 = 0.9336 between the tumor uptake and the tumor mass ranged from 27.6 to 623.9 mg. All three liposomal drugs showed better therapeutic efficacy in small-tumor mice than in large-tumor mice. Tumor-bearing mice treated with InVNBL (a combination drug showed the highest tumor growth inhibition rate and survival fraction compared to those treated with NanoVNB (chemodrug only and InNanoX (radionuclide only. Specific tumor targeting and significantly increased tumor uptake after periodical treatment with InVNBL were evidenced by scintigraphic imaging, especially in mice bearing small tumors. CONCLUSION: The significant differences in the outcomes of cancer treatment and molecular imaging between animals bearing small and large tumors revealed that tumor burden is a critical and discriminative factor in cancer therapy using PEGylated liposomal drugs.

  6. Burden of serious fungal infections in Mexico.

    Science.gov (United States)

    Corzo-León, D E; Armstrong-James, D; Denning, D W

    2015-10-01

    Serious fungal infections (SFIs) could be more frequent than are recognised. Estimates of the incidence and prevalence of SFIs are essential in order to identify public health problems. We estimated the rates of SFIs in Mexico, following a methodology similar to that used in prior studies. We obtained information about the general population and populations at risk. A systematic literature search was undertaken to identify epidemiological reports of SFIs in Mexico. When Mexican reports were unavailable, we based our estimates on international literature. The most prevalent SFIs in Mexico are recurrent vulvovaginal candidiasis (5999 per 100,000) followed by allergic bronchopulmonary aspergillosis (60 per 100,000), chronic pulmonary aspergillosis (15.9 per 100,000), fungal keratitis (10.4 per 100,000), invasive candidiasis (8.6 per 100,000) and SFIs in HIV (8.2 per 100,000); coccidioidomycosis (7.6 per 100,000), IA (4.56 per 100,000). These correspond to 2,749,159 people affected in any year (2.45% of the population), probably >10,000 deaths and 7000 blind eyes. SFIs affect immunocompromised and healthy populations. Most are associated with high morbidity and mortality rates. Validation of these estimates with epidemiological studies is required. The burdens indicate that an urgent need to improve medical skills, surveillance, diagnosis, and management of SFIs exists. PMID:26449505

  7. Perceived Stress: A Better Measure of Caregiver Burden.

    Science.gov (United States)

    Chwalisz, Kathleen; Kisler, Valerie

    1995-01-01

    Reports the results of a study measuring the construct "caregiver burden," as traditionally defined versus when compared to perceived stress. The Perceived Stress Scale was found to be a better predictor of mental and physical health status for 107 spouse caregivers of persons with brain injuries than was a traditional measure of caregiver burden.…

  8. Family burden in injecting versus noninjecting opioid users

    Directory of Open Access Journals (Sweden)

    Naresh Nebhinani

    2013-01-01

    Full Text Available Background: A substance-dependent person in the family affects almost all aspects of family life that also impact the lives of the significant others and causes enormous burden. Objectives: This study was aimed to assess the pattern of burden borne by the family caregivers of patients with opioid-dependence-injecting drug users (IDU and noninjecting drug users (NIDU. Materials and Methods: A cross-sectional study was conducted with ICD-10 diagnosed-opioid-dependent subjects (IDU and NIDU, N = 40 in each group and their family caregivers attending a de-addiction centre at a multispecialty teaching hospital in North India. Family Burden interview schedule was used to assess the pattern of burden borne by the family caregivers. Results: The IDU group was characterized by older age, longer duration of substance dependence, greater subjective and objective family burden in all the areas compared to NIDU group, and single status and unemployment were associated with severe objective burden. The family burden was associated neither with age, education, or duration of dependence of the patients, nor with family size, type of caregiver or caregiver′s education in either group. Conclusion: All caregivers reported a moderate or severe burden, which indicates the significance and need for further work in this area.

  9. Tackling burden in ART: an integrated approach for medical staff

    NARCIS (Netherlands)

    Boivin, J.; Domar, A.D.; Shapiro, D.B.; Wischmann, T.H.; Fauser, B.C.J.M.; Verhaak, C.M.

    2012-01-01

    Discontinuation is a problem in fertility clinics. Many couples discontinue assisted reproductive technologies (ART) without achieving a live birth for reasons other than poor prognosis or the cost of treatment. Discontinuation has been attributed to the burden of treatment. The causes of burden can

  10. Tuberculous Pericarditis is Multibacillary and Bacterial Burden Drives High Mortality

    Directory of Open Access Journals (Sweden)

    Jotam G. Pasipanodya

    2015-11-01

    Interpretation: Patients with culture confirmed tuberculous pericarditis have a high bacillary burden, and this bacterial burden drives mortality. Thus proven tuberculosis pericarditis is not a paucibacillary disease. Moreover, the severe immunosuppression suggests limited inflammation. There is a need for the design of a highly bactericidal regimen for this condition.

  11. Burden and Stress among Psychiatry Residents and Psychiatric Healthcare Providers

    Science.gov (United States)

    Zuardi, Antonio Waldo; Ishara, Sergio; Bandeira, Marina

    2011-01-01

    Purpose: The authors compared the levels of job burden and stress in psychiatry residents with those of other healthcare professionals at inpatient and outpatient psychiatric hospitals in a medium-sized Brazilian city. Method: In this study, the levels of job burden and stress of 136 healthcare workers and 36 psychiatry residents from six various…

  12. 43 CFR 4.1394 - Burden of proof.

    Science.gov (United States)

    2010-10-01

    ... Determinations of Issues Under 30 Cfr Part 761 (federal Program; Federal Lands Program; Federal Program for... review, OSM shall have the burden of going forward to establish a prima facie case and the person who... review, that person shall have the burden of going forward to establish a prima facie case and...

  13. 47 CFR 64.2333 - Burden of proof.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Burden of proof. 64.2333 Section 64.2333 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) MISCELLANEOUS RULES RELATING TO COMMON CARRIERS Subscriber List Information § 64.2333 Burden of proof. (a) In...

  14. Chemical Composition and Medicinal Value of Fruiting Bodies and Submerged Cultured Mycelia of Caterpillar Medicinal Fungus Cordyceps militaris CBS-132098 (Ascomycetes).

    Science.gov (United States)

    Chan, Jannie Siew Lee; Barseghyan, Gayane S; Asatiani, Mikheil D; Wasser, Solomon P

    2015-01-01

    In this paper, we report the results of a proximate analysis (i.e., moisture, ash, protein, fat, carbohydrates, and energy); a bioactive compounds analysis (i.e., cordycepin and ergothioneine); fatty and amino acid analysis; and analyses of vitamin content, macro- and microelement composition of fruiting body (FB), and mycelial biomass (MB) of medicinal caterpillar fungus Cordyceps militaris strain CBS-132098. These results demonstrate that the FB and MB of C. militaris are good sources of proteins: 59.8% protein content in the FB and 39.5% in the MB. The MB was distinguished by its carbohydrate content (39.6%), which was higher than that of the FB (29.1% carbohydrate). In the FB of C. militaris, the total amino acid content was 57.39 mg/g and in the MB it was 24.98 mg/g. The quantification of the identified fatty acids indicated that palmitic acid, oleic acid, linoleic acid, and linolenic acid were the major fatty acids. The micro- and macroelement compositions were studied. The highest results were calcium (797 mg/kg FB; 11 mg/kg MB); potassium (15,938 mg/kg FB 12,183 mg/kg MB); magnesium (4,227 mg/kg FB; 3,414 mg/kg MB); sodium (171 mg/kg FB; 1,567 mg/kg MB); phosphorus (7,196 mg/kg FB; 14,293 mg/kg MB); and sulfur (5,088 mg/kg FB; 2,558 mg/kg MB). The vitamin composition was studied, and the most abundant vitamins were vitamin A, vitamin B3, and vitamin E. The bioactive components were cordycepin, cordycepic acid (D-mannitol), and ergothioneine. There were differences in cordycepin and ergothioneine contents between the FB and the MB. The cordycepin concentration was 0.11% in the FB and 0.182% in the MB, the cordycepic acid was 4.7 mg/100g in the FB and 5.2 mg/100 g in the MB, and the ergothioneine content was 782.37 mg/kg in the FB and 130.65 mg/kg in the MB. The nutritional values of the FB and the MB of C. militaris detected indicate its potential use in well-balanced diets and sources of bioactive compounds. PMID:26559699

  15. The burden of insomnia in Japan

    Directory of Open Access Journals (Sweden)

    Mishima K

    2015-01-01

    Full Text Available Kazuo Mishima,1 Marco daCosta DiBonaventura,2 Hillary Gross2 1Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan; 2Kantar Health, New York, NY, USA Objectives: Several studies have suggested that patients who experience insomnia report a number of significant impairments. However, despite this literature, fewer studies have focused on the burden of insomnia among patients in Japan. The objective of the current study is to extend this work in Japan to further understand the effect of insomnia on health-related quality of life (hrQOL. Further, another objective is to understand general predictors of hrQOL among patients with insomnia. Methods: Data from the 2012 Japan National Health and Wellness Survey, an annual, cross-sectional study of adults aged 18 years or older, were used (N=30,000. All National Health and Wellness Survey respondents were categorized based on the incidence of self-reported insomnia diagnosis and prescription medication usage (clinical insomniacs under treatment versus [vs] good sleepers without insomnia or insomnia symptoms. Comparisons among different groups were made using multiple regression models controlling for demographics and health history. Results: Clinical insomniacs (n=1,018; 3.4% reported significantly worse hrQOL compared with good sleepers (n=20,542 (mental component summary: 34.2 vs 48.0; physical component summary: 48.0 vs 52.8; health utilities: 0.61 vs 0.76; all P<0.05. Health behaviors (smoking, exercise, alcohol use and comorbidities were the strongest predictors of health utilities for clinical insomniacs. For all three clinical insomniac subgroups of interest, those with a physical comorbidity but not a psychiatric one, those with a psychiatric comorbidity but not a physical one, and those without either a physical or psychiatric comorbidity, large decrements in health utilities were observed for respondents who did

  16. Occupational cancer burden in Great Britain.

    Science.gov (United States)

    Rushton, Lesley; Hutchings, Sally J; Fortunato, Lea; Young, Charlotte; Evans, Gareth S; Brown, Terry; Bevan, Ruth; Slack, Rebecca; Holmes, Phillip; Bagga, Sanjeev; Cherrie, John W; Van Tongeren, Martie

    2012-06-19

    A sound knowledge base is required to target resources to reduce workplace exposure to carcinogens. This project aimed to provide an objective estimate of the burden of cancer in Britain due to occupation. This volume presents extensive analyses for all carcinogens and occupational circumstances defined as definite or probable human occupational carcinogens by the International Agency for Research on Cancer. This article outlines the structure of the supplement - two methodological papers (statistical approach and exposure assessment), eight papers presenting the cancer-specific results grouped by broad anatomical site, a paper giving industry sector results and one discussing work-related cancer-prevention strategies. A brief summary of the methods and an overview of the updated overall results are given in this introductory paper. A general discussion of the overall strengths and limitations of the study is also presented. Overall, 8010 (5.3%) total cancer deaths in Britain and 13,598 cancer registrations were attributable to occupation in 2005 and 2004, respectively. The importance of cancer sites such as mesothelioma, sinonasal, lung, nasopharynx, breast, non-melanoma skin cancer, bladder, oesophagus, soft tissue sarcoma and stomach cancers are highlighted, as are carcinogens such as asbestos, mineral oils, solar radiation, silica, diesel engine exhaust, coal tars and pitches, dioxins, environmental tobacco smoke, radon, tetrachloroethylene, arsenic and strong inorganic mists, as well as occupational circumstances such as shift work and occupation as a painter or welder. The methods developed for this project are being adapted by other countries and extended to include social and economic impact evaluation. PMID:22710676

  17. Caregivers’ burden in patients with COPD

    Science.gov (United States)

    Miravitlles, Marc; Peña-Longobardo, Luz María; Oliva-Moreno, Juan; Hidalgo-Vega, Álvaro

    2015-01-01

    Objective Chronic obstructive pulmonary disease (COPD) is a very prevalent and invalidating disease. The aim of this study was to analyze the burden borne by informal caregivers of patients with COPD. Methods We used the Survey on Disabilities, Personal Autonomy, and Dependency Situations (Encuesta sobre Discapacidad, Autonomía personal y Situaciones de Dependencia [EDAD]-2008) to obtain information on the characteristics of disabled individuals with COPD and their caregivers in Spain. Additionally, statistical multivariate analyses were performed to analyze the impact that an increase in dependence would have on the problems for which caregivers provide support, in terms of health, professional, and leisure/social dimensions. Results A total of 461,884 individuals with one or more disabilities and with COPD were identified, and 220,892 informal caregivers were estimated. Results showed that 35% of informal caregivers had health-related problems due to the caregiving provided; 83% had leisure/social-related problems; and among caregivers of working age, 38% recognized having profession-related problems. The probability of a problem arising was significantly associated with the degree of dependence of the patient receiving care. Caregivers of patients with great dependence showed a 39% higher probability of presenting health-related problems, 27% more professional problems, and 23% more leisure problems compared with those with nondependent patients. Conclusion The results show the large impact on society in terms of the welfare of informal caregivers of patients with COPD. A higher level of dependence was associated with more severe problems in caregivers, in all dimensions. PMID:25709429

  18. Arsenic burden survey among refuse incinerator workers

    Directory of Open Access Journals (Sweden)

    Chao Chung-Liang

    2005-01-01

    Full Text Available Background: Incinerator workers are not considered to have arsenic overexposure although they have the risk of overexposure to other heavy metals. Aim: To examine the relationship between arsenic burden and risk of occupational exposure in employees working at a municipal refuse incinerator by determining the concentrations of arsenic in the blood and urine. Settings and Design: The workers were divided into three groups based on their probability of contact with combustion-generated residues, namely Group 1: indirect contact, Group 2: direct contact and Group 3: no contact. Healthy age- and sex-matched residents living in the vicinity were enrolled as the control group. Materials and Methods: Heavy metal concentrations were measured by atomic absorption spectrophotometer. Downstream rivers and drinking water of the residents were examined for environmental arsenic pollution. A questionnaire survey concerning the contact history of arsenic was simultaneously conducted. Statistical analysis: Non-parametric tests, cross-tabulation and multinomial logistic regression. Results: This study recruited 122 incinerator workers. The urine and blood arsenic concentrations as well as incidences of overexposure were significantly higher in the workers than in control subjects. The workers who had indirect or no contact with combustion-generated residues had significantly higher blood arsenic level. Arsenic contact history could not explain the difference. Airborne and waterborne arsenic pollution were not detected. Conclusion: Incinerator workers run the risk of being exposed to arsenic pollution, especially those who have incomplete protection in the workplace even though they only have indirect or no contact with combustion-generated pollutants.

  19. Burden and Unmet Needs of Caregivers of Chronic Obstructive Pulmonary Disease Patients: A Systematic Review of the Volume and Focus of Research Output.

    Science.gov (United States)

    Mansfield, Elise; Bryant, Jamie; Regan, Timothy; Waller, Amy; Boyes, Allison; Sanson-Fisher, Rob

    2016-10-01

    Caregivers of individuals with chronic obstructive pulmonary disease (COPD) experience significant burden. To develop effective interventions to support this vulnerable group, it is necessary to understand how this burden varies as a function of patient well-being and across the illness trajectory. This systematic review aimed to identify the number and type of data-based publications exploring the burden and unmet needs of caregivers of individuals with COPD. Medline, Embase, PsycINFO and Cochrane databases were searched for studies published between January 2000 and February 2014. Studies were eligible if they were quantitative studies examining unmet needs of, or burden on, adult caregivers of individuals with COPD. Eligible papers were categorised according to (i) type (i.e. descriptive, measurement and intervention studies); (ii) whether they measured associations between patient and caregiver burden and (iii) whether they measured caregiver burden longitudinally. Twenty-seven data-based papers met criteria for inclusion. There was a significant increase in the total number of publications over time. The majority of publications were descriptive studies (n = 25), with one measurement and one intervention study identified. Fourteen descriptive studies measured the relationship between patient or caregiver factors and caregiver burden. Only two studies measured caregiver burden over time. There are a number of gaps in the body of research examining burden and unmet needs of caregivers of individuals with COPD that preclude the development of effective interventions for this population. Greater research effort should be directed towards identifying rigorous measurement tools which more accurately characterise caregiver burden, so that evidence-based interventions can be developed. PMID:26979431

  20. Body fluid identification in forensics

    OpenAIRE

    Ja Hyun An1, Kyoung-Jin Shin1,2, Woo Ick Yang1 & Hwan Young Lee1,2,*

    2012-01-01

    At a crime scene can give important insights into crime scenereconstruction by supporting a link between sample donorsand actual criminal acts. For more than a century, numeroustypes of body fluid identification methods have beendeveloped, such as chemical tests, immunological tests,protein catalytic activity tests, spectroscopic methods andmicroscopy. However, these conventional body fluididentification methods are mostly presumptive, and are carriedout for only one body fluid at a time. The...

  1. Body punk

    DEFF Research Database (Denmark)

    Mogensen, Kevin

    BODYPUNK - A Treatise on male body builders and the meaning of the body in the shadow of an Anti Doping Campaign Based on a qualitative study, the thesis investigates the visual representation of the male bodybuilder found in the national anti doping campaign: ‗ "The hunt has begun" along with an...... analysis of the embodied meaning of men‘s bodybuilding....

  2. Body Weight and Body Image

    OpenAIRE

    McFarlane Traci; Olmsted Marion P

    2004-01-01

    Abstract Health Issue Body weight is of physical and psychological importance to Canadian women; it is associated with health status, physical activity, body image, and self-esteem. Although the problems associated with overweight and obesity are indeed serious, there are also problems connected to being underweight. Weight prejudice and the dieting industry intensify body image concerns for Canadian women and can have a major negative impact on self-esteem. Key Findings Women have lower BMIs...

  3. Role of Social Support in Predicting Caregiver Burden

    Science.gov (United States)

    Rodakowski, Juleen; Skidmore, Elizabeth R.; Rogers, Joan C.; Schulz, Richard

    2012-01-01

    Objective To examine the unique contribution of social support to burden in caregivers of adults aging with spinal cord injuries (SCI). Design Secondary analyses of cross-sectional data from a large cohort of adults aging with SCI and their primary caregivers. Setting Multiple community locations in Pittsburgh, PA, and Miami, FL. Participants Caregivers of community-dwelling adults aging with SCI (n=173) were interviewed as part of a multisite randomized clinical trial. The mean age of caregivers was 53 years (SD=15) and of care-recipients 55 years (SD=13). Interventions Not applicable. Main Outcome Measures The primary outcome was caregiver burden measured with the Abridged Version of the Zarit Burden Interview. A hierarchical multiple regression analysis examined social supports (social integration, received social support, and negative social interactions) effect on burden in caregivers of adults aging while controlling for demographic characteristics and caregiving characteristics. Results After controlling for demographic characteristics and caregiving characteristics, social integration (β̂ =−.16, P<.05), received social support (β̂ =−.15, P<.05), and negative social interactions (β̂ =.21, P<.01) were significant independent predictors of caregiver burden. Conclusions Findings demonstrate that social support is an important factor associated with burden in caregivers of adults aging with SCI. Social support should be considered for assessments and interventions designed to identify and reduce caregiver burden. PMID:22824248

  4. Asymmetries of poverty: why global burden of disease valuations underestimate the burden of neglected tropical diseases.

    Directory of Open Access Journals (Sweden)

    Charles H King

    Full Text Available The disability-adjusted life year (DALY initially appeared attractive as a health metric in the Global Burden of Disease (GBD program, as it purports to be a comprehensive health assessment that encompassed premature mortality, morbidity, impairment, and disability. It was originally thought that the DALY would be useful in policy settings, reflecting normative valuations as a standardized unit of ill health. However, the design of the DALY and its use in policy estimates contain inherent flaws that result in systematic undervaluation of the importance of chronic diseases, such as many of the neglected tropical diseases (NTDs, in world health. The conceptual design of the DALY comes out of a perspective largely focused on the individual risk rather than the ecology of disease, thus failing to acknowledge the implications of context on the burden of disease for the poor. It is nonrepresentative of the impact of poverty on disability, which results in the significant underestimation of disability weights for chronic diseases such as the NTDs. Finally, the application of the DALY in policy estimates does not account for the nonlinear effects of poverty in the cost-utility analysis of disease control, effectively discounting the utility of comprehensively treating NTDs. The present DALY framework needs to be substantially revised if the GBD is to become a valid and useful system for determining health priorities.

  5. The Burden of Obesity and Its Sequelae

    OpenAIRE

    Seidell, Jacob C

    1999-01-01

    Obesity [body mass index (BMI) >=30 kg/m2] is common in many parts of the world, especially in the established market economies, formerly socialist economies of Europe and Latin America and the Caribbean, as well as the Middle Eastern Crescent. Worldwide, as many as 250 million people may be obese (7% of the adult population) and 2 to 3 times as many may be considered overweight (BMI 25 to 30 kg/m2). The prevalence of obesity seems to be increasing in most parts of the world, even in areas wh...

  6. The humanistic burden of hereditary angioedema

    DEFF Research Database (Denmark)

    Caballero, Teresa; Aygören-Pürsün, Emel; Bygum, Anette;

    2014-01-01

    extremities; 24% experienced an attack in more than one site. The impact of HAE on daily activities was high during attacks and did not vary significantly by body site affected; patients also reported that HAE impacted their daily activities between attacks. Patients reported substantial anxiety about future...... attacks, traveling, and passing HAE to their children. Based on Hospital Anxiety and Depression Scale scores, 38 and 14% had clinically meaningful anxiety and depression, respectively. Despite standard of care, HAE patients still have frequent and painful attacks. Patients experience substantial...

  7. Technical aspect of integrated body imaging

    International Nuclear Information System (INIS)

    Concerning the integrated body imaging, an optimization of technical aspect in each modarities, such as radiation burden, labour turnover and cost effectiveness should also be considered, in diagnostic process. After investigation on these items, we decided to recommend that imagings of Ultrasound, radionuclide and plain X-ray film should be the first choice for screening, then, CT and X-ray contrast study be the second selected choice and lastly, elaborated contrast angiography be the last one to be selected, if it is necessary. As the increase of information dimension is appeared to be accompanied by the increasing burden in various technical aspect, technical effort to extract more information than those at present at the same burden should be worthwise in future. (author)

  8. A follow-up study on the relationship between thorium lung burden and health effects on miners (1982-91)

    International Nuclear Information System (INIS)

    The results of an investigation on the natural thorium lung burden and its health effects on miners in the Baiyan Obo mine are reported. An electrostatic collection system was used to measure the exhaled thoron activity. Measurements of exhaled thoron activity were carried out on 588 miners (985 measurements) who had inhaled thorium-containing dusts. Exhaled thoron activity was also determined on 124 persons (124 measurements), who had not inhaled thorium-containing dusts. The average thorium lung burdens of the 588 miners and the 124 controls were 0.85 Bq and 0.15 Bq, respectively. Of the 588 miners, 7 had a thorium lung burden higher than 3.7 Bq, 5 had a thorium lung burden higher than 4.44 Bq and 1 miner had the highest thorium lung burden of 5.56 Bq. In about 20% of these miners the thorium lung burden was 0.74 Bq. There was no definite increase in the incidence of lung cancers in more than 2000 miners who had inhaled thorium dusts and thoron daughters in the period 1958-90. Of the miners who had inhaled thorium dusts, there was a significant increase in the incidence of respiratory symptoms, lung function disorders and pneumoconiosis stage 0+ and stage 1. Based on the results of animal experiments and the low percentage of thorium in the dust, the authors suggest that disorders of the respiratory tract were due mainly to other chemical components in the dust, such as SiO2 and other chemical elements. The role of thorium is negligible. (author)

  9. Global burden of disease--a race against time

    DEFF Research Database (Denmark)

    Meyrowitsch, Dan W; Bygbjerg, Ib Christian

    2007-01-01

    Low-income communities will within the next decades undergo rapid changes. The burden of non-communicable diseases (NCDs), such as diabetes, cardio-vascular disease and cancer, will comprise an increasing proportion of the total disease burden. The results of projections indicate that the already...... constrained health systems will face a double burden of disease, in which HIV/AIDS and other common infectious diseases will co-exist with the new NCDs. In order for preventive measures directed towards NCD to be cost-effective, these have to be implemented within the next 10-20 years....

  10. Double burden of malnutrition: A silent driver of double burden of disease in low– and middle–income countries

    Directory of Open Access Journals (Sweden)

    Ivana Kolcˇic´

    2012-09-01

    Full Text Available Double burden of malnutrition, characterised by undernutrition among poor children and obesity among deprived adults, is a serious global problem and an important promoter of ‘double burden of disease’ which is currently affecting low– and middle–income countries. Possible ways to reduce this burden is through education on the importance of equilibrium between energy intake and expenditure; ensuring conditions for optimal fetal and early child development; and reducing poverty as one of the main drivers of both undernutrition and obesity, through empowering local communities.

  11. Outdoor air dominates burden of disease from indoor exposures

    DEFF Research Database (Denmark)

    Hänninen, O.; Asikainen, A.; Carrer, P.; Kephalopoulos, S.; de Oliveira Fernandes, E.; Wargocki, Pawel

    Both indoor and outdoor sources of air pollution have significant public health impacts in Europe. Based on quantitative modelling of the burden of disease the outdoor sources dominate the impacts by a clear margin....

  12. 10 CFR 205.192A - Burden of proof.

    Science.gov (United States)

    2010-01-01

    ... Remedial Order proceeding the ERA has the burden of establishing a prima facie case as to the validity of... supplemental information that may be made available under § 205.193A. (b) Once a prima facie case has...

  13. Renewable energy burden sharing. REBUS. Manual for the REBUS model

    International Nuclear Information System (INIS)

    The REBUS model quantifies the effects of implementing renewable electricity targets, and the impact of introducing burden sharing systems within the EU, such as a Tradable Green Certificate (TGC) system. Results are obtained for a range of so-called burden sharing options that reflect differences in economic, social and geographical possibilities to increase the share of renewables in individual geographical regions. The REBUS model furthermore analyses the impact of other supporting mechanisms for renewable electricity on the effects of a burden sharing mechanism. With this, the REBUS model is a framework that can be used for quantifying the most equitable distribution of costs (burden sharing) and compare consequences of different equity criteria. Therewith it aims to support key policy makers, industrial stakeholders and consumers in making decisions on the possibilities to achieve their joint RES-E targets

  14. Body lice

    Science.gov (United States)

    Lice - body; Pediculosis corporis; Vagabond disease ... Diaz JH. Lice (pediculosis). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases . 8th ...

  15. Bog bodies

    DEFF Research Database (Denmark)

    Lynnerup, Niels

    2015-01-01

    the bog bodies have been studied using medical and natural scientific methods, and recently many bog bodies have been re-examined using especially modern, medical imaging techniques. Because of the preservation of soft tissue, especially the skin, it has been possible to determine lesions and trauma......In northern Europe during the Iron Age, many corpses were deposited in bogs. The cold, wet and anaerobic environment leads in many cases to the preservation of soft tissues, so that the bodies, when found and excavated several thousand years later, are remarkably intact. Since the 19th century....... Conversely, the preservation of bones is less good, as the mineral component has been leached out by the acidic bog. Together with water-logging of collagenous tissue, this means that if the bog body is simply left to dry out when found, as was the case pre-19th century, the bones may literally warp...

  16. Everyday burden of musculoskeletal conditions among villagers in rural Botswana

    DEFF Research Database (Denmark)

    Hondras, Maria; Hartvigsen, Jan; Myburgh, Corrie; Johannessen, Helle

    2016-01-01

    OBJECTIVE: To examine the perspectives of villagers in rural Botswana about the everyday life burden and impact of their musculoskeletal disorders. METHODS: Ethnographic fieldwork for 8 months included 55 in-depth interviews with 34 villagers. Interviews were typically conducted in Setswana with ...... care needs in developing country settings. Community-engaged partnerships are needed to develop rehabilitation programmes to ease the burden of musculoskeletal disorders in rural Botswana....

  17. National Economic Burden Associated with Management of Periodontitis in Malaysia

    OpenAIRE

    Tuti Ningseh Mohd Dom; Rasidah Ayob; Khairiyah Abd Muttalib; Syed Mohamed Aljunid

    2016-01-01

    Objectives. The aim of this study is to estimate the economic burden associated with the management of periodontitis in Malaysia from the societal perspective. Methods. We estimated the economic burden of periodontitis by combining the disease prevalence with its treatment costs. We estimated treatment costs (with 2012 value of Malaysian Ringgit) using the cost-of-illness approach and included both direct and indirect costs. We used the National Oral Health Survey for Adults (2010) data to es...

  18. Economic and Disease Burden of Dengue in Southeast Asia

    OpenAIRE

    Undurraga, Eduardo A.; Halasa, Yara A.; Donald S Shepard

    2013-01-01

    BACKGROUND: Dengue virus infection is the most common arthropod-borne disease of humans and its geographical range and infection rates are increasing. Health policy decisions require information about the disease burden, but surveillance systems usually underreport the total number of cases. These may be estimated by multiplying reported cases by an expansion factor (EF). METHODS AND FINDINGS: As a key step to estimate the economic and disease burden of dengue in Southeast Asia (SEA), we proj...

  19. Rent Seeking and the Excess Burden of Taxation

    OpenAIRE

    Kahana, Nava; Klunover, Doron

    2014-01-01

    The social costs of rent seeking are generally evaluated with respect to rent dissipation. A common assumption is complete rent dissipation so that the value of a contested rent is the value of social loss. When rent seekers earn taxable income, there is interdependence between the social cost of rent seeking through rent dissipation and the excess burden of taxation. Through the addition of substitution to rent seeking beyond leisure, rent seeking increases the excess burden of taxation unde...

  20. Caregiver Burden and Psychoeducational Interventions in Alzheimer's Disease: A Review

    OpenAIRE

    Beinart, N.; Weinman, J; Wade, D; Brady, R

    2012-01-01

    Background Caring for a patient with Alzheimer's disease (AD) is associated with poor quality of life and deteriorating health for the caregiver. Methods This comprehensive review was performed to investigate the current literature on caregiver burden, factors affecting caregiver burden and the effectiveness of different types of intervention. Results Successful psychoeducational interventions for caregivers have included provision of information about AD, care planning, advice about patient ...

  1. FEATURES OF DEFINITION OF TAX BURDEN OF AN ECONOMIC ENTITY

    OpenAIRE

    Sobchenko N. V.; Kuleshova L. V.; Lapina E. N.

    2015-01-01

    The results of an analytical assessment of the developed frame of reference on concepts of tax planning, tax burden, tax burden of the enterprise are presented in article. Tax planning is the most important part of financial planning of the organization. A basis of this process is possibility of each taxpayer to use legislatively resolved means, receptions and ways directed on minimization of tax payments. Minimization of taxes is directed not only on absolute decrease in volumes of tax payme...

  2. Burden and quality of life of caregivers for hemodialysis patients.

    Science.gov (United States)

    Belasco, Angelica G; Sesso, Ricardo

    2002-04-01

    The aim of this study is to describe the characteristics of caregivers of chronic hemodialysis patients, assess their perceived burden and health-related quality of life, and investigate factors influencing this burden. We studied 100 hemodialysis patients and their respective primary caregivers for more than 4 months, measuring quality of life by the Medical Outcomes Survey 36-Item Short-Form Health Survey (SF-36). Subjective burden on caregivers was assessed by the Caregiver Burden scale (score range, 1 to 4; higher values indicate a greater effect). The majority of caregivers were women (84%), married (66%), with a mean age of 46 +/- 2 (SE) years, and of low socioeconomic level. Their main types of relationship with patients were wives (38%) and sons or daughters (27%). Caregiver Mental Health and Vitality were the most affected emotional dimensions on the SF-36 (mean scores, 64.4 +/- 1.8 and 66.6 +/- 1.7, respectively). Mean score of total burden experienced was 2.07 +/- 0.05. Multiple regression analysis showed that independent and significant predictors of burden were Mental Health of the caregiver (R2 = 24%), Vitality of the patient (R2 = 10%), type of relationship of the caregiver (female spouse) (R2 = 5%), and Pain of the caregiver (R2 = 3%). Caregivers of hemodialysis patients may experience a significant burden and an adverse effect on their quality of life. Emotional aspects of caregivers (particularly female spouses) and patients are important predictors of burden. Social support and psychological interventions should be considered to improve caregiver life and patient outcomes. PMID:11920347

  3. The burden and treatment of diabetes in France

    OpenAIRE

    Chevreul, Karine; Berg Brigham, Karen; Bouché, Clara

    2014-01-01

    Background The objective of this review was to describe and situate the burden and treatment of diabetes within the broader context of the French health care system. Methods Literature review on the burden, treatment and outcomes of diabetes in France, complemented by personal communication with with diabetes experts in the Paris public hospital system. Results Prevalence of diabetes in the French population is estimated at 6%. Diabetes has the highest prevalence among all chronic conditions ...

  4. Economic and Disease Burden of Dengue in Southeast Asia

    OpenAIRE

    Undurraga, Eduardo A.; Halasa, Yara A.; Donald S. Shepard

    2013-01-01

    Background Dengue virus infection is the most common arthropod-borne disease of humans and its geographical range and infection rates are increasing. Health policy decisions require information about the disease burden, but surveillance systems usually underreport the total number of cases. These may be estimated by multiplying reported cases by an expansion factor (EF). Methods and Findings As a key step to estimate the economic and disease burden of dengue in Southeast Asia (SEA), we projec...

  5. Dementia caregiver burden: reliability of the Brazilian version of the Zarit caregiver burden interview

    Directory of Open Access Journals (Sweden)

    Taub Anita

    2004-01-01

    Full Text Available The object of this article is to examine the reliability of the Brazilian version of the Zarit Caregiver Burden Interview (ZBI. The instrument is a 22-item scale assessing the extent to which caregivers view their responsibilities as having an adverse impact on their social life, health, emotional well-being, and finances. We assessed 50 primary informal caregivers of demented patients coming from 3 different health care centers, using the test-retest method. Analysis of the results showed an intraclass reliability coefficient of 0.88, while Cronbach's coefficient alpha was 0.77 for the test and 0.80 for the retest items. The Brazilian version of ZBI shows sufficient reliability, comparable to the original version.

  6. Asbestos lung burden and asbestosis after occupational and environmental exposure in an asbestos cement manufacturing area: a necropsy study

    OpenAIRE

    Magnani, C; Mollo, F.; Paoletti, L.; BELLIS, D.; P. Bernardi; Betta, P.; Botta, M; Falchi, M.; Ivaldi, C; Pavesi, M.

    1998-01-01

    OBJECTIVE: The largest Italian asbestos cement factory had been active in Casale Monferrato until 1986: in previous studies a substantial increase in the incidence of pleural mesothelioma was found among residents without occupational exposure to asbestos. To estimate exposure to asbestos in the population, this study evaluated the presence of histological asbestosis and the lung burden of asbestos fibres (AFs) and asbestos bodies (ABs). METHODS: The study comprises the consecutive seri...

  7. Estimating the true global burden of mental illness.

    Science.gov (United States)

    Vigo, Daniel; Thornicroft, Graham; Atun, Rifat

    2016-02-01

    We argue that the global burden of mental illness is underestimated and examine the reasons for under-estimation to identify five main causes: overlap between psychiatric and neurological disorders; the grouping of suicide and self-harm as a separate category; conflation of all chronic pain syndromes with musculoskeletal disorders; exclusion of personality disorders from disease burden calculations; and inadequate consideration of the contribution of severe mental illness to mortality from associated causes. Using published data, we estimate the disease burden for mental illness to show that the global burden of mental illness accounts for 32·4% of years lived with disability (YLDs) and 13·0% of disability-adjusted life-years (DALYs), instead of the earlier estimates suggesting 21·2% of YLDs and 7·1% of DALYs. Currently used approaches underestimate the burden of mental illness by more than a third. Our estimates place mental illness a distant first in global burden of disease in terms of YLDs, and level with cardiovascular and circulatory diseases in terms of DALYs. The unacceptable apathy of governments and funders of global health must be overcome to mitigate the human, social, and economic costs of mental illness. PMID:26851330

  8. State plans to force companies to eliminate environmental burdens

    International Nuclear Information System (INIS)

    The Ministry of Environment is preparing legislation aimed at forcing the state and especially private enterprises to map and eliminate tips, refuse from company premises and farmyards, and manure heaps. It is expected that the main burden will fall on private enterprises. The department is still working on the wording of this new Act on environmental burdens and so it is not yet clear whether it will be of assistance in the elimination of environmental burdens. The Ministry is aware that economic aspects must also be taken into account when exercising pressure on the companies. Closing down a company that cannot meet environmental criteria would result in redundancies and so the time schedule for the elimination of environmental burdens will be adjusted to fit the financial situation of the company involved. The ministry plans to first find companies responsible for environmental debts and then set a deadline for the preparation of a project to eliminate the environmental burden. The project would have to contain a description of elimination methods, in addition to a time schedule and cost assessment. If a private company does not report an environmental burden, the competent public authority will have the power to request access to the premises to undertake an inspection. (author)

  9. Burden among male Alzheimer's caregivers: effects of distinct coping strategies.

    Science.gov (United States)

    Geiger, Jennifer R; Wilks, Scott E; Lovelace, Lauren L; Chen, Zibei; Spivey, Christina A

    2015-05-01

    Focusing on the understudied, increasing population of male Alzheimer's disease (AD) caregivers, the purpose of this study was to identify their likelihood of utilizing 3 coping strategies (task focused, emotion focused, and avoidance focused) and to examine the effects of each coping strategy on caregiving burden. Data were collected from 138 male AD caregivers in southern United States, including geographically proportional representation of African Americans in the sample. Stepwise regression revealed effects of each coping strategy on caregiving burden, controlling for demographics. The sample reported high burden. Task focused was the highest reported coping strategy. Yet, regression models indicated no significant effect of task-focused coping on burden outcomes. Emotion-focused and avoidance-focused coping each showed significant proportional effects on burden. Implications suggest that emotion- and avoidance-focused coping among male AD caregivers may be maladaptive, that is, reinforcing burden. Male AD caregivers may benefit from more task-focused coping, such as planning and active problem solving. PMID:25267930

  10. Burden of Noise Induced Hearing Loss among Manufacturing Industrial Workers in Malaysia

    Directory of Open Access Journals (Sweden)

    Noraita TAHIR

    2015-10-01

    Full Text Available Background: Noise induced hearing loss (NIHL is the highest reported occupational disease among industrial workers but there is scarcity of data on disease burden in Malaysia. This study estimated the risks and burden of NIHL in manufacturing industries in Malaysia.Methods: This cross-sectional industrial survey was conducted by interviewing OSH practitioners at 26 industries categorized as food, tobacco, textile, wearing apparel, wood products except furniture, paper, refined petroleum, chemicals, non-metallic mineral, basic metal, fabricated metal, motor vehicle parts. The catchment population is imputed based on stratified sampling design involving 60% of workers diagnosed with NIHL.Results: A total of 18 industries exposed to noise level of 86-90dBA and 8 industries at more than 91dBA were identified. All industries provide regular awareness training and hearing protection device to their workers but none of them implement attenuation, majority of them (81% conduct onsite audiometric test annually. In overall, the risk of NIHL and incidence per 100,000 manufacturing workers projected is 8% (139 new cases, the highest risk and incidence is 32% (26 in motor vehicle parts industry; followed by 23% (1140 new cases in tobacco industry and 23% (269 new cases in fabricated metal industry. Male workers (89% were exposed to a greater risk compared to female (11%. It was estimated that 103,000 workers were potentially affected by NIHL in Malaysia.Conclusion: NIHL is a major burden among industrial workers in Malaysia. Implementation of effective hearing conservation program and self-enforcement of noise regulations by the employer could potentially reduce the burden. Keywords: Noise, Hearing loss, Manufacturing, Malaysia

  11. 不同体长斑纹舌鰕虎鱼鱼体成分的研究%Studies on the Chemical Composition of Glossogobius olivaceus from at Different Body composition

    Institute of Scientific and Technical Information of China (English)

    林小植; 李冬梅

    2012-01-01

    To observe the variation of body composition of Gkasogobius olivaceus, 36 specimens were collected from the lower reaches of Hanjiang River in June, 2010, and divided into 5 groups according to the body length (91.0 -100.0, 101.0 - 110.0, 111. 0 -120. 0, 121. 0 -130.0 and 131.0 -140. 0 mm). Chemical compositions were measured and energy density was estimated The results showed (hat the contents of water, protein, lipid and ash (represented by percentage in fresh body weight of fish) ranged 72.57% ~ 75. 98% , 13.76% - 17.40% , 6. 32% - 9.23% and 2.66% -3.20% , respectively. The energy density (E) ranged 5.74 - 7.75 kj/g. With the increase of body lenth (L), the content of protein (PRO), the content of protein lipid (FAT) and the energy density ( E) increased significantly, while the content of ash and the content of water ( WAT) decreased significantly. The contents of PRO, FAT and E are all positively correlated with body weight ( W) ( P < 0. 01), while ASH and WAT are negatively correlated with W ( P < 0.01). The contents of PRO, FAT and E are all negatively correlated with WAT, but ASH is positively correlated with WAT (P < 0.01).%为探讨斑纹舌鰕虎鱼(Glossogobius olivaceus)鱼体化学成分随生长的变化规律,2010年6月于韩江下游潮州江段采集斑纹舌鰕虎鱼36尾,按体长(91.0- 100.0、101.0 - 110.0、111.0- 120.0、121.0-130.0和131.0 -140.0mm)分为5个组,分别测定鱼体化学成分,估算其能量密度.结果显示,斑纹舌鰕虎鱼鱼体含水量(WAT)、蛋白质含量(PRO)、脂肪(FAT)、灰分含量(ASH)占鲜重的比例范围分别为72.57%~75.98%、13.76% ~ 17.40%、6.32% ~9.23%和2.66% ~3.20%,能量密度范围为5.70~7.75 kJ/g;各体长组间PRO、FAT和能量密度均随体长的增加而增加,且与体重呈极显著的正线性关系(P<0.01),但WAT、ASH反随体长的增加而减少,且与体重呈负线性相关关系(P<0.01);分析还表明,WAT与PRO、FAT、能量密度呈极

  12. The Mood Disorder Burden Index: A Scale for Assessing the Burden of Caregivers to Adults with Unipolar or Bipolar Disorder

    Science.gov (United States)

    Martire, Lynn M.; Hinrichsen, Gregory A.; Morse, Jennifer Q.; Reynolds, Charles F.; Gildengers, Ariel G.; Mulsant, Benoit H.; Schulz, Richard

    2009-01-01

    In this paper we present a brief measure of caregiver burden, the Mood Disorder Burden Index (MDBI), for use with family members and close friends of adults with major depressive disorder (MDD) or bipolar disorder (BD). The MDBI assesses burden in three core domains (patients’ mood symptoms, caregivers’ worry about the future, and caregivers’ interpersonal difficulties with the patient) and includes an optional module that assesses caregiver burden associated with patients’ pharmacotherapy or psychotherapy. The MDBI was administered to caregivers of older individuals (i.e., 58 years and older) with MDD (n = 123) or BD (n = 38 who were receiving treatment through a research study. Analyses indicated evidence of convergent and discriminant validity of the new measure well as internal consistency within both caregiver groups. It will be important for future research to administer the MDBI to caregivers of middle-aged and older patients as well as those receiving treatment through inpatient settings or community outpatient clinics. PMID:19427705

  13. Evolutionary constraints over microsatellite abundance in larger mammals as a potential mechanism against carcinogenic burden.

    Science.gov (United States)

    Park, Jung Youn; An, Yong-Rock; An, Chul-Min; Kang, Jung-Ha; Kim, Eun Mi; Kim, Heebal; Cho, Seoae; Kim, Jaemin

    2016-01-01

    Larger organisms tend to live longer, have more potentially carcinogenic cells, and undergo more cell divisions. While one might intuitively expect cancer incidence to scale with body size, this assertion does not hold over the range of different mammals. Explaining this lack of correlation, so-called 'Peto's paradox' can likely increase our understanding of how cancer defense mechanisms are shaped by natural selection. Here, we study the occurrence of microsatellite in mammal genomes and observe that animals with expanded body size restrain the number of microsatellite. To take into account of higher mutation rate in the microsatellite region compared to that of genome, limiting the abundance of somatic mutations might explain how larger organisms could overcome the burden of cancer. These observations may serve as the basis to better understand how evolution has modeled protective mechanisms against cancer development. PMID:27125812

  14. [Mortui vivos docent?--experienced burdens of medical students in the gross anatomy course].

    Science.gov (United States)

    Limbrecht, Kerstin; Brinkmann, Anke; Lamp, Christoph; Böckers, Anja; Böckers, Tobias; Traue, Harald C; Jerg-Bretzke, Lucia

    2013-08-01

    The dissection course (here abbreviated: PK) is still an obligatory part of medical schools in Germany. In this study we investigated the experiences and burdens of medical students in gross anatomy, especially "distancing from the human body".This study was carried out three times with the self-composed questionnaire BF-PK: before, while and after PK. In total 371 students participated in the PK. 297 students participated at measurement 1. In advance 25-30% of the medical students reported anxiety and emotional inhibition, during the course only 7-10%. The coping strategy "distancing from the human body" was prominent. Anxiety, emotional inhibition and disgust remained for 5-10% of the participants.The gross anatomy course causes emotional stress for a considerable amount of medical students. For those students that were not able to overcome the mental stress themselves service offers should be implemented. PMID:23468367

  15. Identification of environmentally derived cesium-137 burdens in a worker population

    International Nuclear Information System (INIS)

    During 1990, whole body measurements of a number of workers with little probability of onsite occupational exposure showed positive evidence of 137Cs. Further investigation revealed that many of these workers supplemented their diet with a significant portion of wild game, mainly deer and elk. To validate the assumption of an environmental source, donated samples of venison and other game were analyzed by gamma spectroscopy. Results ranged from less than 0.1 to almost 100 Bq kg-l (0.003 to 2.7 nCi kg-1) and showed a correlation with the habitat from which the game was taken. Venison samples obtained from the two workers with the highest body burdens showed the highest activity. A questionnaire is now used to identify workers with an elevated potential for environmental-intakes

  16. Dioxin body burden among blood donors before and after the Belgian dioxin/PCB incident

    Energy Technology Data Exchange (ETDEWEB)

    Debacker, N.; Sasse, A.; Wouwe, N. Van; Windal, I.; Carbonnelle, S.; Overmeire, I. Van; Sartor, F.; Goeyens, L.; Oyen, H. Van [Scientific Inst. of Public Health, Brussels (Belgium); Eppe, G.; Xhrouet, C.; Pauw, E. De [Centre of Analysis of Residues in Traces, Luik (Belgium)

    2004-09-15

    In spring 1999, Belgium faced a severe food contamination when about 50 kg of PCBs containing 1 g of dioxins were introduced in the food chain. The possible public health impact of this food chain contamination was subject of a debate between different scientists. According to Vrijens et al. and Bernard et al. there was no significant public health impact, whereas van Larebeke et al. presumed the opposite claiming a significant increase of cancer incidence. These risk assessments were based on measurements of dioxins/PCBs in contaminated foods and nutritional habits observed in a selected group of adolescents (14-18 years old) using simulation techniques or on the estimation of the incremental cancer risk associated with the incremental levels of exposure to dioxins/PCBs during the incident. In the meantime, an epidemiological survey has been carried out in order to measure the dioxin levels in plasma samples collected before and after the incident. The aim of this paper is to report the preliminary results of this epidemiological survey.

  17. Incidence of liver tumors in beagles with body burdens of 239Pu or 241Am

    International Nuclear Information System (INIS)

    Tetravalent 239Pu or trivalent 241Am in a citrate buffer, given via a single intravenous injection to beagles, induced very pronounced liver changes, usually at relatively long postinjection times. The lesions consisted of cell injury or cell necrosis which was followed by nodular hyperplasia and a significant incidence of primary liver tumors. The most frequent neoplasm was the bile duct adenoma, followed by the bile duct carcinoma. A lesser number of sarcomas were also induced, especially fibrosarcomas. The number of hepatic cell tumors was low. An abnormally high incidence of both hyperplastic nodules and primary liver tumors occurred at long postinjection times and at average doses extending down to ∼10 rads. The various nodular lesions and liver tumors frequently occurred as incidental findings in dogs dying from other causes, especially bone cancer. In comparison to bone neoplasia, the liver was a much less important target organ in the high-dose level groups, but in some of the low-dose groups, especially in the 241Am groups, the risk of radiation-induced liver cancer was approximately equal to or exceeded the risk of skeletal tumors. However, in any projection of the risks observed in this animal model to man, one should be mindful that the beagle skeleton is approximately 25 times more sensitive to radiation-induced bone neoplasia than is the human skeleton (Mays et al., 1976) and that the radiosensitivity difference for the beagle and human liver is unknown. 41 refs., 8 figs., 5 tabs

  18. America's Children and the Environment: Measures of Contaminants, Body Burdens, and Illnesses. Second Edition.

    Science.gov (United States)

    Woodruff, Tracey J.; Axelrad, Daniel A.; Kyle, Amy D.; Nweke, Onyemaechi; Miller, Gregory G.

    Noting that children may be affected by environmental contaminants in ways quite different from the way adults are affected, this report is the second on trends in measures reflecting environmental factors that may affect the U.S. children's health and well-being. A list of measures and key findings begins the report, followed by five main…

  19. Body burdens of persistent halogenated compounds during different development stages of anadromous brown trout (Salmo trutta).

    Science.gov (United States)

    Svendsen, Tore C; Vorkamp, Katrin; Frederiksen, Marie; Rønsholdt, Bent; Frier, Jens-Ole

    2007-09-01

    Polychlorinated biphenyls (PCBs), DDTs, and polybrominated diphenyl ethers (PBDEs) were followed through the five life stages of a wild population of anadromous brown trout and related to variations in lipid content and exposure situations. Anadromous brown trout exhibits great variations in lipid content during its life cycle in the freshwater and marine environments. The results indicated substantial differences in PBDE and organochlorine exposure, with apparently more recent sources of PBDEs in the freshwater environment relative to the marine environment. Lipid and contaminant transfer were not always identical: The concentrations of PCBs, DDTs, and PBDEs (ng/g lipid weight) were about 15 times lower in the eggs compared to the muscle of their mother (e.g., 823 ng PCB/g Iw vs. 12,565 ng PCB/g lw, respectively). During the starving period from maiden to spawning trout the contaminant load increased by a higher factor than the lipid use. The data suggest a decoupling between lipid content and organohalogen concentrations for anadromous brown trout, which may contribute positively to reduce any potential negative effects of the transferred contaminants on eggs and fry. PMID:17937270

  20. Utilizing In Vitro Derived Metabolic Rate Constants to Inform Pesticide Body Burdens in Amphibians

    Science.gov (United States)

    Over 2.4 billion kilograms of pesticides have been used worldwide in preventing diseases, dealing with nuisance animals and aiding in crop management Although pesticides are used to control insects and diseases, exposure to non-target species frequently occurs.Amphibians are impo...

  1. The significance of hair mineral analysis for assessing internal body burdens of environmental mineral pollutants

    International Nuclear Information System (INIS)

    Samples from 24 male corpses have been collected to study the correlation of minerals in hair to those in internal tissues (liver, kidney, lung and brain) by NAA. Positive correlations of As in hair to that in kidney and Se in hair to Se in liver, kidney and lung have been observed

  2. Exposure and body burden of polychlorinated biphenyls (PCB) and metals in a historically contaminated community.

    Science.gov (United States)

    Helmfrid, Ingela; Salihovic, Samira; van Bavel, Bert; Wingren, Gun; Berglund, Marika

    2015-03-01

    There are many small villages where environmental contamination is substantial due to historical industrial activities. The aim of the present study was to investigate if long-term or current consumption of local foods, as reported in food frequency questionnaires, co-vary with measured concentrations of polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), lead (Pb), cadmium (Cd) and mercury (Hg) in blood, urine and hair from a population living in a historically contaminated village. Blood, urine and hair were provided by men (n=38) and women (n=57), who had participated in a previous case-control study in the contaminated area, and were analyzed for PCB, OCPs, Pb, Cd and Hg. A detailed food frequency questionnaire, used in the previous epidemiological study, was repeated, and up-dated information of life-style, exposure factors and other covariates was collected. Associations between reported consumption of local foods and exposure biomarkers were explored in relation to age, gender, life-style factors and other covariates. A large part of the population in the area reported consumption of local food, and thus, was potentially exposed to the contaminants. Despite the limited number of participants and other weaknesses described, it was possible to link reported consumption of different foods to biomarker concentrations. Reported consumption of local vegetables, forest berries and mushrooms co-varied with urinary Cd, indicating an influence from the contaminated area on the Cd exposure. We found no associations between PCB plasma concentrations with reported consumption of local fish, but with consumption of herring (non-local sea fish) which is typically high in PCB. Pesticide (HCB, p,p'-DDE, trans-nonachlor) exposure was mainly associated with agricultural work and having a private well the first five years of life, but we found no associations between pesticide concentrations in plasma and consumption of local vegetables or fish. Exposure to Hg was associated with consumption of fish, both local and non-local, and Pb exposure was associated with the consumption of game. Overall, the contaminant concentrations measured in blood, urine and hair varied substantially among study participants, but on average, the concentrations were similar to concentrations measured in other groups of the general Swedish population in the same age range. Larger studies are needed to evaluate health risks (and causality) associated with historical environmental contamination. PMID:25529270

  3. Quantifying Amphibian Pesticide Body Burdens for Active Ingredients Versus Formulations Through Dermal Exposure

    Science.gov (United States)

    Widespread pesticide applications throughout agricultural landscapes pose a risk to post-metamorphic amphibians leaving or moving between breeding ponds in terrestrial habitats. Recent studies indicate that the inactive ingredients in pesticide formulations may be equally or more...

  4. New Evidence on Variations of Human Body Burden of Methylmercury from Fish Consumption

    OpenAIRE

    Canuel, René; Grosbois, Sylvie Boucher de; Atikessé, Laura; Lucotte, Marc; Arp, Paul; Ritchie, Charles; Mergler, Donna; Chan, Hing Man; Amyot, Marc; Anderson, Robin

    2006-01-01

    Epidemiologic studies commonly use mercury (Hg) level in hair as a valid proxy to estimate human exposure to methylmercury (MeHg) through fish consumption. This study presents the results yielded by a complete data set on fish consumption habits, Hg levels in edible fish resources, and corresponding Hg accumulation in hair, gathered in three distinct communities of eastern Canada. For one of these communities, the average hair Hg concentration was 14 times less than the expected value based o...

  5. NEUROSENSORY EFFECTS OF CHRONIC HUMAN EXPOSURE TO ARSENIC ASSOCIATED WITH BODY BURDEN AND ENVIRONMENTAL MEASURES

    Science.gov (United States)

    Exposure to arsenic in drinking water is known to produce a variety of health problems including peripheral neuropathy. Auditory, visual and somatosensory impairments have been reported in Mongolian farmers living in the Yellow River Valley where drinking water is contami...

  6. Influence of heavy metals body burden on biochemical peculiarities of small mammals

    Directory of Open Access Journals (Sweden)

    O. A. Zemlianyj

    2007-01-01

    Full Text Available The influence of technogenic pollution on the protein and lipid content in small mammals from different ecosystems is observed in the paper. It was defined that its content increased in organs, which take an active part in the metabolic processes.

  7. Signifying Bodies

    DEFF Research Database (Denmark)

     In our everyday lives we strive to stay healthy and happy, while we live as our selves, engage with each other, and discover an infinite world of possibilities. Health arises and diminishes as human beings draw on a vibrant ecology of actions, interactions and coactions. Intricate processes of...... biosemiosis connect signifying bodies with their natural surroundings, cultural activities and subjective experiences. Health stretches all the way from the ecosocial surroundings, through the skin and into the self-organizing processes of every living cell. Signifying Bodies lays out a new approach to health...... and health care. Eschewing all forms of dualism, the authors emphasise the interdependency of how we act, think, feel and function. They advocate a relational turn in health care, in which bodies live and learn from suffering and care. In this view, health is inseparable from both living beings and...

  8. Body Imaging

    Science.gov (United States)

    2001-01-01

    The high-tech art of digital signal processing (DSP) was pioneered at NASA's Jet Propulsion Laboratory (JPL) in the mid-1960s for use in the Apollo Lunar Landing Program. Designed to computer enhance pictures of the Moon, this technology became the basis for the Landsat Earth resources satellites and subsequently has been incorporated into a broad range of Earthbound medical and diagnostic tools. DSP is employed in advanced body imaging techniques including Computer-Aided Tomography, also known as CT and CATScan, and Magnetic Resonance Imaging (MRI). CT images are collected by irradiating a thin slice of the body with a fan-shaped x-ray beam from a number of directions around the body's perimeter. A tomographic (slice-like) picture is reconstructed from these multiple views by a computer. MRI employs a magnetic field and radio waves, rather than x-rays, to create images.

  9. Estimating the burden of paratyphoid a in Asia and Africa.

    Directory of Open Access Journals (Sweden)

    Michael B Arndt

    2014-06-01

    Full Text Available Despite the increasing availability of typhoid vaccine in many regions, global estimates of mortality attributable to enteric fever appear stable. While both Salmonella enterica serovar Typhi (S. Typhi and serovar Paratyphi (S. Paratyphi cause enteric fever, limited data exist estimating the burden of S. Paratyphi, particularly in Asia and Africa. We performed a systematic review of both English and Chinese-language databases to estimate the regional burden of paratyphoid within Africa and Asia. Distinct from previous reviews of the topic, we have presented two separate measures of burden; both incidence and proportion of enteric fever attributable to paratyphoid. Included articles reported laboratory-confirmed Salmonella serovar classification, provided clear methods on sampling strategy, defined the age range of participants, and specified the time period of the study. A total of 64 full-text articles satisfied inclusion criteria and were included in the qualitative synthesis. Paratyphoid A was commonly identified as a cause of enteric fever throughout Asia. The highest incidence estimates in Asia came from China; four studies estimated incidence rates of over 150 cases/100,000 person-years. Paratyphoid A burden estimates from Africa were extremely limited and with the exception of Nigeria, few population or hospital-based studies from Africa reported significant Paratyphoid A burden. While significant gaps exist in the existing population-level estimates of paratyphoid burden in Asia and Africa, available data suggest that paratyphoid A is a significant cause of enteric fever in Asia. The high variability in documented incidence and proportion estimates of paratyphoid suggest considerable geospatial variability in the burden of paratyphoid fever. Additional efforts to monitor enteric fever at the population level will be necessary in order to accurately quantify the public health threat posed by S. Paratyphi A, and to improve the prevention

  10. Economic and disease burden of dengue in Southeast Asia.

    Directory of Open Access Journals (Sweden)

    Donald S Shepard

    Full Text Available BACKGROUND: Dengue poses a substantial economic and disease burden in Southeast Asia (SEA. Quantifying this burden is critical to set policy priorities and disease-control strategies. METHODS AND FINDINGS: We estimated the economic and disease burden of dengue in 12 countries in SEA: Bhutan, Brunei, Cambodia, East-Timor, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, and Viet Nam. We obtained reported cases from multiple sources--surveillance data, World Health Organization (WHO, and published studies--and adjusted for underreporting using expansion factors from previous literature. We obtained unit costs per episode through a systematic literature review, and completed missing data using linear regressions. We excluded costs such as prevention and vector control, and long-term sequelae of dengue. Over the decade of 2001-2010, we obtained an annual average of 2.9 million (m dengue episodes and 5,906 deaths. The annual economic burden (with 95% certainty levels was US$950m (US$610m-US$1,384m or about US$1.65 (US$1.06-US$2.41 per capita. The annual number of disability-adjusted life years (DALYs, based on the original 1994 definition, was 214,000 (120,000-299,000, which is equivalent to 372 (210-520 DALYs per million inhabitants. CONCLUSION: Dengue poses a substantial economic and disease burden in SEA with a DALY burden per million inhabitants in the region. This burden is higher than that of 17 other conditions, including Japanese encephalitis, upper respiratory infections, and hepatitis B.

  11. Treatment of Late-Life Depression Alleviates Caregiver Burden

    Science.gov (United States)

    Martire, Lynn M.; Schulz, Richard; Reynolds, Charles F.; Karp, Jordan F.; Gildengers, Ariel G.; Whyte, Ellen M.

    2010-01-01

    Objectives To describe the burden experienced by family caregivers of older adults with depression and to examine the positive effects on caregivers of treating late-life depression. Design Two-phase treatment study for major depressive disorder (MDD) that included 6 weeks of open treatment with antidepressant medication for all older patients followed by 16 weeks of randomized treatment for patients who were partial responders, comparing a combination of medication and interpersonal psychotherapy with medication alone. Setting Primary care and university late-life mental health research clinic. Participants Adults aged 60 and older participating in a randomized trial for treatment of MDD who enrolled in a family caregiver study and their caregiver (N = 244 dyads). Measurements Improvement in patient symptoms during open treatment (lower scores on the Hamilton Rating Scale for Depression (HRSD)) and remission of depression during randomized treatment (3 consecutive weekly HRSD scores of ≤7) were examined as predictors of lower general caregiver burden and burden specific to patient depression. Results Caregivers reported a moderate to high level of general caregiver burden on average. Change in patient depression during open treatment was associated with significantly decreased depression-specific burden (β = −0.22, P =.001) and a trend toward lower general burden (β = − 0.08, P =.08). Caregivers of patients who remitted showed significantly decreased depression-specific burden (F (1,76) = 4.27, P =.04). Conclusion Treatment of late-life depression has benefits that extend to the family members on whom patients depend. Caregiver education and support may strengthen these effects. PMID:19943833

  12. Estimating the global burden of endemic canine rabies.

    Directory of Open Access Journals (Sweden)

    Katie Hampson

    2015-04-01

    Full Text Available Rabies is a notoriously underreported and neglected disease of low-income countries. This study aims to estimate the public health and economic burden of rabies circulating in domestic dog populations, globally and on a country-by-country basis, allowing an objective assessment of how much this preventable disease costs endemic countries.We established relationships between rabies mortality and rabies prevention and control measures, which we incorporated into a model framework. We used data derived from extensive literature searches and questionnaires on disease incidence, control interventions and preventative measures within this framework to estimate the disease burden. The burden of rabies impacts on public health sector budgets, local communities and livestock economies, with the highest risk of rabies in the poorest regions of the world. This study estimates that globally canine rabies causes approximately 59,000 (95% Confidence Intervals: 25-159,000 human deaths, over 3.7 million (95% CIs: 1.6-10.4 million disability-adjusted life years (DALYs and 8.6 billion USD (95% CIs: 2.9-21.5 billion economic losses annually. The largest component of the economic burden is due to premature death (55%, followed by direct costs of post-exposure prophylaxis (PEP, 20% and lost income whilst seeking PEP (15.5%, with only limited costs to the veterinary sector due to dog vaccination (1.5%, and additional costs to communities from livestock losses (6%.This study demonstrates that investment in dog vaccination, the single most effective way of reducing the disease burden, has been inadequate and that the availability and affordability of PEP needs improving. Collaborative investments by medical and veterinary sectors could dramatically reduce the current large, and unnecessary, burden of rabies on affected communities. Improved surveillance is needed to reduce uncertainty in burden estimates and to monitor the impacts of control efforts.

  13. Body Rainbow

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    Phubu did not know how long hehad walked after leaving Baxoi, buthe did know that he was halfwaybetween home and Lhasa. Feelingthe weight of the sack containingPhumo's body on his back, Fhubuhad calmed down from the grief anddesperation. He had just one wish:to carry Phumo to Lhasa. He knewthat Phumo had gone, and her soulwas no longer in this body. But hewas determined to finish the trip, notonly because he had promised so, butalso that he believed that it would beredemption for him.

  14. Sacralising Bodies

    DEFF Research Database (Denmark)

    Kaur, Ravinder

    2010-01-01

    sacralisation is realised through co-production within a social setting when the object of sacralisation is recognised as such by others. In contemporary Iran, however, the moment of sacralising bodies by the state is also the moment of its own subversion as the political-theological field of martyrdom is......-sacrifice became central to the mass mobilisation against the monarchy. Once the revolutionary government came into existence, this sacred tradition was regulated to create ‘martyrs’ as a fixed category, in order to consolidate the legacy of the revolution. In this political theatre, the dead body is a site of...

  15. Global economic burden of schizophrenia: a systematic review

    Directory of Open Access Journals (Sweden)

    Chong HY

    2016-02-01

    Full Text Available Huey Yi Chong,1 Siew Li Teoh,1 David Bin-Chia Wu,1 Surachai Kotirum,1 Chiun-Fang Chiou,2 Nathorn Chaiyakunapruk1,3–5 1School of Pharmacy, Monash University Malaysia, Selangor, Malaysia; 2Janssen Pharmaceutical Companies Asia Pacific, Singapore; 3Center of Pharmaceutical Outcomes Research (CPOR, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand; 4School of Pharmacy, University of Wisconsin, Madison, WI, USA; 5School of Population Health, University of Queensland, Brisbane, Australia Background: Schizophrenia is one of the top 25 leading causes of disability worldwide in 2013. Despite its low prevalence, its health, social, and economic burden has been tremendous, not only for patients but also for families, caregivers, and the wider society. The magnitude of disease burden investigated in an economic burden study is an important source to policymakers in decision making. This study aims to systematically identify studies focusing on the economic burden of schizophrenia, describe the methods and data sources used, and summarize the findings of economic burden of schizophrenia. Methods: A systematic review was performed for economic burden studies in schizophrenia using four electronic databases (Medline, EMBASE, PsycINFO, and EconLit from inception to August 31, 2014. Results: A total of 56 articles were included in this review. More than 80% of the studies were conducted in high-income countries. Most studies had undertaken a retrospective- and prevalence-based study design. The bottom-up approach was commonly employed to determine cost, while human capital method was used for indirect cost estimation. Database and literature were the most commonly used data sources in cost estimation in high-income countries, while chart review and interview were the main data sources in low and middle-income countries. Annual costs for the schizophrenia population in the country ranged from US$94

  16. BURDEN OF ABNORMAL HEMATOPOIETIC CLONE IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Objective To investigate the role of the burden of abnormal hematopoietic clone in the development of myelodys plastic syndromes (MDS).Methods The ratio of the bone marrow cells with abnormal chromosomes to the total counted bone marrow cells was regarded as the index of MDS clone burden. The disease severity related parameters including white blood cell count, hemoglobin, platelet count, lactate dehydrogenase level, bone marrow blast, myeloid differentiation index, micromegakaryocyte, transfusion, interleukin-2, tumor necrosis factor ( TNF), CD4 + and CD8 + T cells of MDS patients were assayed, and the correlations between those parameters and MDS clone burden were also analyzed.Results The clone burden of MDS patients was 67.4% ± 36. 2%. MDS clone burden positively correlated with bone marrow blasts (r=0.483, P<0.05), negatively with hemoglobin level (r=-0.445, P<0.05). The number of blasts, hemoglobin, and erythrocytes in high clone burden (>50%) and low clone burden (≤50%) groups were 7.78%±5.51% and 3.45%±3.34%, 56.06±14. 28 g/L and 76.40±24.44 g/L, (1.82±0.48)×1012/L and (2. 32±0.66)×1012/L, respectively (all P <0.05). CD4 + T lymphocytes of MDS patients and normal controls were (0. 274±0.719)×109/L and (0.455±0.206)×109/L, respectively (P<0.05). CD8 ± T lymphocytes of MDS patients and normal controls were (0.240±0.150)×109/L and (0.305 ±0.145)×109/L, respectively. The serum level of interleukin-2 of MDS patients (6.29±3.58 ng/mL) was significantly higher than normal control (3.11±1.40ng/mL, P<0.05). The serum level of TNF of MDS patients and normal control group were 2.42±1.79 ng/mL and 1.68 ±0.69 ng/mL, respectively. The ratio of CD4 to CD8 was higher in high clone burden MDS patients (1.90 ±0.52) than that in low clone burden patients (0.97±0.44, P<0.05).Conclusion The quantitive clonal karyotype abnormalities and deficient T cell immunity are important parameters for evaluating MDS severity and predicting its

  17. A review of the economic burden of ADHD

    Directory of Open Access Journals (Sweden)

    Paramore Clark

    2005-06-01

    Full Text Available Abstract Attention-deficit hyperactivity disorder (ADHD is a common disorder that is associated with broad functional impairment among both children and adults. The purpose of this paper is to review and summarize available literature on the economic costs of ADHD, as well as potential economic benefits of treating this condition. A literature search was performed using MEDLINE to identify all published articles on the economic implications of ADHD, and authors were contacted to locate conference abstracts and articles in press that were not yet indexed. In total, 22 relevant items were located including published original studies, economic review articles, conference presentations, and reports available on the Internet. All costs were updated and presented in terms of year 2004 US dollars. A growing body of literature, primarily published in the United States, has demonstrated that ADHD places a substantial economic burden on patients, families, and third-party payers. Results of the medical cost studies consistently indicated that children with ADHD had higher annual medical costs than either matched controls (difference ranged from $503 to $1,343 or non-matched controls (difference ranged from $207 to $1,560 without ADHD. Two studies of adult samples found similar results, with significantly higher annual medical costs among adults with ADHD (ranging from $4,929 to $5,651 than among matched controls (ranging from $1,473 to $2,771. A limited number of studies have examined other economic implications of ADHD including costs to families; costs of criminality among individuals with ADHD; costs related to common psychiatric and medical comorbidities of ADHD; indirect costs associated with work loss among adults with ADHD; and costs of accidents among individuals with ADHD. Treatment cost-effectiveness studies have primarily focused on methylphenidate, which is a cost-effective treatment option with cost-effectiveness ratios ranging from $15

  18. Large orthotopic reservoir stone burden: Role of open surgery

    Directory of Open Access Journals (Sweden)

    Madbouly Khaled

    2010-01-01

    Full Text Available Purpose: To present our experience in open poucholithotomy as a primary management of large orthotopic reservoir stone burden and discuss different management options. Materials and Methods: Records of men underwent radical cystectomy and orthotopic urinary diversion were retrospectively reviewed as regards pouch stone formation. Patients with large reservoir stone burden managed by open poucholithotomy were further selected. Results: Large reservoir stone burden was encountered in 12 post radical cystectomy men. All underwent open poucholithotomy as a primary management of their reservoir stones. Median age at cystectomy was 46 (range: 32-55 years with a median total follow up period of 214.15 (range: 147-257 months and a median interval to stone detection of 99 (range: 63-132 months. The median stone burden was 5260 (range: 3179-20410 mm 2 . All patients were continent during the day while 5 showed nocturnal enuresis; 2 of them became continent after removal of the stones. Post poucholithotomy, all patients had sterile urine cultures except one who showed occasional colonization. None of the 12 patients showed stone recurrence after poucholithotomy. Two patients underwent revision of a dessuscepted nipple valve in association with stone removal. Conclusions: Open poucholithotomy for large reservoir stone burden is a feasible and safe option. It saves the reservoir mesentery and adjacent bowel. It allows complete removal of the stone(s leaving no residual fragments. Furthermore, it permits correction of concomitant reservoir abnormalities.

  19. FEATURES OF DEFINITION OF TAX BURDEN OF AN ECONOMIC ENTITY

    Directory of Open Access Journals (Sweden)

    Sobchenko N. V.

    2015-12-01

    Full Text Available The results of an analytical assessment of the developed frame of reference on concepts of tax planning, tax burden, tax burden of the enterprise are presented in article. Tax planning is the most important part of financial planning of the organization. A basis of this process is possibility of each taxpayer to use legislatively resolved means, receptions and ways directed on minimization of tax payments. Minimization of taxes is directed not only on absolute decrease in volumes of tax payments, but also on purposeful transfer of business to more favorable conditions of managing. Tax planning is connected with recognition of the right of each taxpayer to apply all legislatively resolved means, receptions and ways to decrease in tax payments. The analysis of a condition of tax burden of an economic entity of real sector of economy is carried out. It is noted, that by means of various techniques of its assessment it is possible to receive contradictory data on dynamics of change of level of tax burden. As one of factors of increasing the efficiency of business activity is optimization of tax payments and implementation of tax planning acts. Importance of realization of tax planning and optimization of tax payments is defined by desire of taxpayers to lower tax burden and explainable aspiration of the state to prevent it

  20. The burden of non communicable diseases in developing countries

    Directory of Open Access Journals (Sweden)

    Boutayeb Abdesslam

    2005-01-01

    Full Text Available Abstract Background By the dawn of the third millennium, non communicable diseases are sweeping the entire globe, with an increasing trend in developing countries where, the transition imposes more constraints to deal with the double burden of infective and non-infective diseases in a poor environment characterised by ill-health systems. By 2020, it is predicted that these diseases will be causing seven out of every 10 deaths in developing countries. Many of the non communicable diseases can be prevented by tackling associated risk factors. Methods Data from national registries and international organisms are collected, compared and analyzed. The focus is made on the growing burden of non communicable diseases in developing countries. Results Among non communicable diseases, special attention is devoted to cardiovascular diseases, diabetes, cancer and chronic pulmonary diseases. Their burden is affecting countries worldwide but with a growing trend in developing countries. Preventive strategies must take into account the growing trend of risk factors correlated to these diseases. Conclusion Non communicable diseases are more and more prevalent in developing countries where they double the burden of infective diseases. If the present trend is maintained, the health systems in low-and middle-income countries will be unable to support the burden of disease. Prominent causes for heart disease, diabetes, cancer and pulmonary diseases can be prevented but urgent (preventive actions are needed and efficient strategies should deal seriously with risk factors like smoking, alcohol, physical inactivity and western diet.

  1. Metabolic Burden: Cornerstones in Synthetic Biology and Metabolic Engineering Applications.

    Science.gov (United States)

    Wu, Gang; Yan, Qiang; Jones, J Andrew; Tang, Yinjie J; Fong, Stephen S; Koffas, Mattheos A G

    2016-08-01

    Engineering cell metabolism for bioproduction not only consumes building blocks and energy molecules (e.g., ATP) but also triggers energetic inefficiency inside the cell. The metabolic burdens on microbial workhorses lead to undesirable physiological changes, placing hidden constraints on host productivity. We discuss cell physiological responses to metabolic burdens, as well as strategies to identify and resolve the carbon and energy burden problems, including metabolic balancing, enhancing respiration, dynamic regulatory systems, chromosomal engineering, decoupling cell growth with production phases, and co-utilization of nutrient resources. To design robust strains with high chances of success in industrial settings, novel genome-scale models (GSMs), (13)C-metabolic flux analysis (MFA), and machine-learning approaches are needed for weighting, standardizing, and predicting metabolic costs. PMID:26996613

  2. Relationship quality and elder caregiver burden in India

    Directory of Open Access Journals (Sweden)

    Rashmi Gupta

    2012-06-01

    Full Text Available Relationship quality and elder caregiver burden in India The purpose of this study was to examine the psychosocial factors that contribute to burden among Asian Indian caregivers of the elderly in Allahabad, India. Within this context of caregiving, the importance of relationship quality as a determinant of burden was examined in 259 Asian Indian families. A stress process model was utilized to explain the quality of relationship between the caregiver and the elderly persons. Another factor predicting burden was role overload. In addition, it was found that there were several indirect effects through relationship quality that predicted burden. The findings suggest that psycho educational interventions may be gainfully used to reduce burden among caregivers of elderly in India. Mantelzorg in India: de kwaliteit van de relatie tussen mantelzorger en zorgbehoevende oudere en de ervaren zorg last In deze studie staat de relatie tussen diverse psychosociale factoren en de ervaren zorg last van mantelzorgers (van ouderen in Allahabad (India centraal. Als belangrijke voorspeller van de ervaren zorg last wordt “de kwaliteit van de relatie” tussen mantelzorger en zorgbehoevende gezien. Deze wordt in de theoretische verkenning van het artikel verder uitgewerkt aan de hand van een zogenaamd “stress-proces-model”. Op basis van vragenlijstonderzoek, uitgevoerd onder 259 families, wordt geconcludeerd dat “overbelasting” een belangrijke voorspeller van zorg last is. Ook blijken er verscheidene indirecte effecten van de kwaliteit van de relatie te zijn. De uitkomsten suggereren dat er een mogelijke rol voor psychosociale interventies in het reduceren van de ervaren zorg last onder mantelzorgers in India is weggelegd.

  3. Health burden of urban transport: The technical challenge

    Indian Academy of Sciences (India)

    Carlos Dora

    2007-08-01

    The burden on health-related issues due to unplanned urban policies is higher despite the present knowledge of interventions and availability of current technologies. This burden could increase substantially, given the rapid growth in urban populations and the application of partial or misguided solutions to urban transport problems. Part of the reason is the failure to consider holistically the health, social and environment consequences and the related costs of individual travel choices and government policies in the field of traffic and mobility. Urban transport-related issues and its impact on health, environment, costs and benefits are discussed in this paper.

  4. Economic and disease burden of dengue in Mexico.

    Directory of Open Access Journals (Sweden)

    Eduardo A Undurraga

    2015-03-01

    Full Text Available Dengue imposes a substantial economic and disease burden in most tropical and subtropical countries. Dengue incidence and severity have dramatically increased in Mexico during the past decades. Having objective and comparable estimates of the economic burden of dengue is essential to inform health policy, increase disease awareness, and assess the impact of dengue prevention and control technologies.We estimated the annual economic and disease burden of dengue in Mexico for the years 2010-2011. We merged multiple data sources, including a prospective cohort study; patient interviews and macro-costing from major hospitals; surveillance, budget, and health data from the Ministry of Health; WHO cost estimates; and available literature. We conducted a probabilistic sensitivity analysis using Monte Carlo simulations to derive 95% certainty levels (CL for our estimates. Results suggest that Mexico had about 139,000 (95%CL: 128,000-253,000 symptomatic and 119 (95%CL: 75-171 fatal dengue episodes annually on average (2010-2011, compared to an average of 30,941 symptomatic and 59 fatal dengue episodes reported. The annual cost, including surveillance and vector control, was US$170 (95%CL: 151-292 million, or $1.56 (95%CL: 1.38-2.68 per capita, comparable to other countries in the region. Of this, $87 (95%CL: 87-209 million or $0.80 per capita (95%CL: 0.62-1.12 corresponds to illness. Annual disease burden averaged 65 (95%CL: 36-99 disability-adjusted life years (DALYs per million population. Inclusion of long-term sequelae, co-morbidities, impact on tourism, and health system disruption during outbreaks would further increase estimated economic and disease burden.With this study, Mexico joins Panama, Puerto Rico, Nicaragua, and Thailand as the only countries or areas worldwide with comprehensive (illness and preventive empirical estimates of dengue burden. Burden varies annually; during an outbreak, dengue burden may be significantly higher than that of

  5. Economic and Disease Burden of Dengue in Mexico

    Science.gov (United States)

    Undurraga, Eduardo A.; Betancourt-Cravioto, Miguel; Ramos-Castañeda, José; Martínez-Vega, Ruth; Méndez-Galván, Jorge; Gubler, Duane J.; Guzmán, María G.; Halstead, Scott B.; Harris, Eva; Kuri-Morales, Pablo; Tapia-Conyer, Roberto; Shepard, Donald S.

    2015-01-01

    Background Dengue imposes a substantial economic and disease burden in most tropical and subtropical countries. Dengue incidence and severity have dramatically increased in Mexico during the past decades. Having objective and comparable estimates of the economic burden of dengue is essential to inform health policy, increase disease awareness, and assess the impact of dengue prevention and control technologies. Methods and Findings We estimated the annual economic and disease burden of dengue in Mexico for the years 2010–2011. We merged multiple data sources, including a prospective cohort study; patient interviews and macro-costing from major hospitals; surveillance, budget, and health data from the Ministry of Health; WHO cost estimates; and available literature. We conducted a probabilistic sensitivity analysis using Monte Carlo simulations to derive 95% certainty levels (CL) for our estimates. Results suggest that Mexico had about 139,000 (95%CL: 128,000–253,000) symptomatic and 119 (95%CL: 75–171) fatal dengue episodes annually on average (2010–2011), compared to an average of 30,941 symptomatic and 59 fatal dengue episodes reported. The annual cost, including surveillance and vector control, was US$170 (95%CL: 151–292) million, or $1.56 (95%CL: 1.38–2.68) per capita, comparable to other countries in the region. Of this, $87 (95%CL: 87–209) million or $0.80 per capita (95%CL: 0.62–1.12) corresponds to illness. Annual disease burden averaged 65 (95%CL: 36–99) disability-adjusted life years (DALYs) per million population. Inclusion of long-term sequelae, co-morbidities, impact on tourism, and health system disruption during outbreaks would further increase estimated economic and disease burden. Conclusion With this study, Mexico joins Panama, Puerto Rico, Nicaragua, and Thailand as the only countries or areas worldwide with comprehensive (illness and preventive) empirical estimates of dengue burden. Burden varies annually; during an outbreak

  6. Burden differentiation: criteria for evaluation and development of burden sharing rules. The Joint CICERO-ECN project on sharing the burden of greenhouse gas reduction among countries

    International Nuclear Information System (INIS)

    This article discusses nine criteria for evaluation of potential Burden Sharing Rules (BSRs) in climate policy agreements. Three of the criteria reflect fairness principles while six of them are operational requirements. These criteria are useful for identifying potential BSRs that could be promising in future climate policy negotiations. The two sector approaches, Multi-sector Convergence Approach and Triptych, received the highest score according to the criteria presented in this article. The Multi-sector Convergence Approach was developed in the joint ECN (Netherlands Energy Research Foundation) and CICERO (Center for International Climate and Environmental Research - Oslo) project on burden sharing in climate policy agreements. This is a sector-oriented approach that comprises convergence of per capita emissions to the same level for all countries, and has a global coverage. The Triptych approach has been employed by the European Union for their internal differentiation of national abatement targets. Sector approaches have some specific advantages in linking burden sharing to the economic structure of countries. This indicates that the Multi-sector Convergence Approach could play a useful role in climate policy negotiations among a larger group of countries, and could encourage developing countries to take on greenhouse gas abatement targets. (author)

  7. Double Burden of Malnutrition in Rural West Java: Household-Level Analysis for Father-Child and Mother-Child Pairs and the Association with Dietary Intake

    Directory of Open Access Journals (Sweden)

    Makiko Sekiyama

    2015-10-01

    Full Text Available Indonesia is facing household-level double burden malnutrition. This study aimed at examining (1 household-level double burden for the mother-child and father-child pairs; (2 risk of adiposity of double burden households; and (3 associated dietary factors. Subjects were 5th and 6th grade elementary school children (n = 242, their mothers (n = 242, and their fathers (n = 225 in five communities (1 = urban, 4 = rural in the Bandung District. Questionnaires on socioeconomic factors, blood hemoglobin measurements, and anthropometric measurements were administered. For adults, body fat percentage (BF% was estimated by bioelectrical impedance (BF%-BI and by converting skinfold thickness (ST data using Durnin and Womersley’s (1974 formula (BF%-ST. Food frequency questionnaires were also completed. Double burden was defined as coexistence of maternal or paternal overweight (Body mass index (BMI ≥ 23 and child stunting (height-for-age z-score <−2 within households. Maternal-child double burden occurred in 30.6% of total households, whereas paternal-child double burden was only in 8.4%. Mothers from double burden households showed high adiposity; 87.3% with BF%-BI and 66.2% with BF%-ST had BF% >35%, and 60.6% had waists >80 cm. The major dietary patterns identified were “Modern” and “High-animal products”. After controlling for confounding factors, children in the highest quartile of the “High-animal products” dietary pattern had a lower risk of maternal-child double burden (Adjusted OR: 0.46, 95% CI: 0.21–1.04 than those in the lowest quartile. Given that the “High-animal products” dietary pattern was associated with the decreased risk of maternal-child double burden through a strong negative correlation with child stunting, improving child stunting through adequate intake of animal products is critical to solve the problem of maternal-child double burden in Indonesia.

  8. Levels od PCDDs, PCDFs, and PCBs in the blood of the non-occupationally exposed residents living in the vicinity of a chemical plant, comparison with a background level for the Czech population

    Energy Technology Data Exchange (ETDEWEB)

    Cerna, M.; Kratenova, J.; Maly, M.; Volf, J.; Smid, J.; Zejglicova, K. [National Inst. of Public Health, Prague (Czech Republic); Bajgar, L.; Kozak, J. [Regional Inst. of Public Health, Central Bohemia (Czech Republic); Crhova, S.; Grabic, R. [Inst. of Public Health, Ostrava (Czech Republic)

    2004-09-15

    The Czech Republic ranks among to the countries with a relatively high body burden of PCBs that used to be produced in former Czechoslovakia, more precisely in Slovakia, until 1984 when the production was abolished. In 1994, nation-wide Environmental Health Monitoring System was implemented in the Czech Republic. Indicator PCB congeners and selected chlorinated pesticides started to be monitored in human body fluids and tissues of the Czech population. The indicator PCB levels in breast milk samples showed a significant downward trend in time with regional inter- and intra-individual variability. However, to measure the population body burden of dioxins, blood is considered to be more appropriate than other body fluids. Little has been known about body burden of PCDDs, PCDFs and dioxin-like PCBs in the Czech population. Sporadic data are only available on level of dioxins in the breast milk, or for several pooled blood samples analyzed within the Environmental Health Monitoring System. More than 35 years ago, approximately 80 Czech workers were occupationally exposed to 2,3,7,8- TCDD in a chemical factory producing chlorinated herbicides and pesticides in Central Bohemia. Still in 1996, they showed a mean 2,3,7,8-TCDD plasma level of 256 pg/g fat. It was supposed that also the residents living surrounding the plant might be at increased exposure risk. The objective of this study was (a) to investigate concentrations of PCDDs/PCDFs/PCBs in blood samples from non-occupationally exposed residents living in the vicinity of a chemical plant and (b) to compare the results with the background concentrations available for PCDDs/PCDFs/PCBs in blood samples from the evidently non-exposed Czech population.

  9. Effect of gut clearance on metal body concentrations in Hyalella azteca

    Energy Technology Data Exchange (ETDEWEB)

    Neumann, P.T.M.; Borgmann, U.; Norwood, W. [Environment Canada, Burlington, Ontario (Canada)

    1999-05-01

    Gut content can contribute significantly to the metal body burdens in sediment-exposed Hyalella azteca even if it has no direct effect on toxicity. To determine the duration and the effect of gut clearance on total body concentrations, the authors exposed H. azteca for 1 week to a spiked sediment (lead, cadmium, zinc, and copper); a second set of amphipods was kept in cages above the sediment. Following transfer into clean water (25 C) for 96 h, lead and zinc concentrations showed a biphasic decline, with a stronger decrease in the first 4 to 6 h, when gut clearance contributes significantly to metal loss. After 6 h, metal loss was apparently due to excretion from the body. Without gut clearance, the body concentrations of lead and zinc in sediment-exposed amphipods were overestimated by 438 and 44%, respectively. Gut clearance did not have a visible effect on cadmium and copper body burdens because the body and sediment concentrations were similar. After a depuration time of 6 h, direct excretion from the body resulted in a drop of less than 10% in the total body burdens of lead, cadmium, zinc, and copper compared to the gut-corrected time-zero body burdens. After 24 h, this loss increased up to 27%. Feeding during the depuration period did not have a significant influence on gut clearance. A model that allows estimation of the influence of gut content on the total body concentration of undepurated invertebrates from the bioconcentration factor is evaluated.

  10. Night work, total occupational burden and cancer/cardiovascular risk factors in physicians

    Directory of Open Access Journals (Sweden)

    Nedić Olesja

    2012-01-01

    Full Text Available Introduction. Lifestyle-related risk factors: smoking, obesity, sedentariness and excess alcohol intake are among the most important known causes of cancer and cardiovascular disease. The aim of this study is to examine the relationship between these lifestyle-related risk factors for cancer/cardiovascular disease and working conditions among surgeons/anesthesiologists and other physicians. Material and Methods. The study was carried out among physicians aged 35 to 60, without diagnosed coronary heart disease or other structural heart disease, who were employed at the Novi Sad University Hospital. The participation rate was high (> 90%. The physicians completed the Occupational Stress Index. Low lifestyle-related cancer/cardiovascular risk was defined as: not a current smoker, body mass index < 28, regular recreational physical activity and not consuming alcohol every day. Analysis of covariance was performed. Results. Of 191 physicians included in this study only 23 (12.0% had a low lifestyle- related cancer/cardiovascular risk. Surgeons/anesthesiologists faced a heavier total work stressor burden than physicians in other profiles (87.7±8.8 versus 74.1±10.5, p=0.000. Among the 56 surgeons/anesthesiologists, lower nightshift work scores were associated with low lifestyle-related cancer/cardiovascular risk (F=4.19, p=0.046. A lower overall work stressor burden was associated with low risk among the other 135 physicians (F=4.06, p=0.046. Conclusion. Specific workplace intervention strategies are urgently needed. Among the surgeons/anesthesiologists these should include reduction in the frequency of night call and improvement of the overall conditions of nightshift work. Among other physicians, the total occupational burden needs to be diminished.

  11. Total blubber burden of organochlorine pollutants in phocid seals; methods and suggested standardization.

    Science.gov (United States)

    Kleivane, L; Severinsen, T; Lydersen, C; Berg, V; Skaare, J U

    2004-03-29

    The purpose of the present paper was to investigate methods for calculating the total blubber burden of organochlorine pollutants (OCs) in phocid seals. Harp seals (Phoca groenlandica) were used as the model species. A sample of fat pre-breeding adult females (N = 9) and a sample of thin moulting adult females (N = 7) were collected. From each animal blubber samples from five different body sites (complete blubber columns and samples from different blubber layers), in addition to a sample from a homogenate derived from the entire blubber mass, were analyzed for selected OCs. Significant differences in the concentrations of major OC contaminants were found between inner and outer blubber layer. Within each seal group, no significant difference in OC concentrations was found between homogenates from whole blubber columns from the five different sites of the animals or when comparing these with the OC concentrations found in the blubber sample deriving from a homogenate of the entire blubber mass. When comparing the two seal groups, the mean OC concentrations were significantly higher in the thin seals. However, blubber burden of OCs measured directly and calculated indirectly were not significantly different, and did not vary between the two groups of seals. Since these seals are of the same age and sex group and from the same population, this is not an unexpected result. The present results suggest that comparison of blubber concentrations of OCs in phocid seals should be avoided, especially when comparing differences between geographical areas or for time-trend analyses. For this type of study, we suggest that the blubber burden of OCs is applied as standard in the future. Furthermore, since blubber depth at a specific sampling site is required when using the estimator for calculation of the percent blubber content in phocid seals (the LMD-index), we suggest that this sampling site (central dorsally) is introduced as a standard when sampling blubber for OC analyses

  12. Psychosocial correlates of illness burden in chronic fatigue syndrome.

    Science.gov (United States)

    Antoni, M H; Brickman, A; Lutgendorf, S; Klimas, N; Imia-Fins, A; Ironson, G; Quillian, R; Miguez, M J; van Riel, F; Morgan, R

    1994-01-01

    We related reported physical symptoms, cognitive appraisals (e.g., negative style of thinking), and coping strategies (e.g., denial/disengagement strategies) with illness burden across several functional domains separately in subsets of chronic fatigue syndrome (CFS) patients with (n = 26) and without (n = 39) concurrently diagnosed major depressive disorder (MDD). In regard to cognitive appraisal measures, automatic thoughts and dysfunctional attitudes were strongly associated with a higher illness burden, as indicated in sickness impact profile (SIP) scores. Active-involvement coping strategies measured on COPE scales (active coping, planning, and positive reinterpretation and growth) were not associated with SIP scores, while other coping strategies (mental disengagement, behavioral disengagement, and denial) were positively correlated with psychosocial and physical SIP scales, especially those pertaining to interpersonal life-style arenas. After we accounted for the number of different CFS-specific physical complaints reported and DSM-III-R depression diagnosis status, cognitive appraisals and coping strategies predicted a substantial proportion of the variance in the severity of illness burden. For the most part, the magnitude of these relationships between our predictor model variables and illness burden severity was similar in the MDD and non-MDD subgroups. PMID:8148457

  13. The burden of rotavirus disease in Denmark 2009-2010

    DEFF Research Database (Denmark)

    Fischer, Thea Kølsen; Rungø, Christine; Jensen, Claus Sixtus;

    2011-01-01

    BACKGROUND: This study sought to determine the incidence and the burden of severe diarrheal disease in Denmark with emphasis on rotavirus (RV) disease. METHODS: This study was designed as a national prospective disease surveillance of children <5 years of age hospitalized for acute gastroenteriti...

  14. National Economic Burden Associated with Management of Periodontitis in Malaysia.

    Science.gov (United States)

    Mohd Dom, Tuti Ningseh; Ayob, Rasidah; Abd Muttalib, Khairiyah; Aljunid, Syed Mohamed

    2016-01-01

    Objectives. The aim of this study is to estimate the economic burden associated with the management of periodontitis in Malaysia from the societal perspective. Methods. We estimated the economic burden of periodontitis by combining the disease prevalence with its treatment costs. We estimated treatment costs (with 2012 value of Malaysian Ringgit) using the cost-of-illness approach and included both direct and indirect costs. We used the National Oral Health Survey for Adults (2010) data to estimate the prevalence of periodontitis and 2010 national census data to estimate the adult population at risk for periodontitis. Results. The economic burden of managing all cases of periodontitis at the national level from the societal perspective was approximately MYR 32.5 billion, accounting for 3.83% of the 2012 Gross Domestic Product of the country. It would cost the nation MYR 18.3 billion to treat patients with moderate periodontitis and MYR 13.7 billion to treat patients with severe periodontitis. Conclusion. The economic burden of periodontitis in Malaysia is substantial and comparable with that of other chronic diseases in the country. This is attributable to its high prevalence and high cost of treatment. Judicious application of promotive, preventive, and curative approaches to periodontitis management is decidedly warranted. PMID:27092180

  15. National Economic Burden Associated with Management of Periodontitis in Malaysia

    Directory of Open Access Journals (Sweden)

    Tuti Ningseh Mohd Dom

    2016-01-01

    Full Text Available Objectives. The aim of this study is to estimate the economic burden associated with the management of periodontitis in Malaysia from the societal perspective. Methods. We estimated the economic burden of periodontitis by combining the disease prevalence with its treatment costs. We estimated treatment costs (with 2012 value of Malaysian Ringgit using the cost-of-illness approach and included both direct and indirect costs. We used the National Oral Health Survey for Adults (2010 data to estimate the prevalence of periodontitis and 2010 national census data to estimate the adult population at risk for periodontitis. Results. The economic burden of managing all cases of periodontitis at the national level from the societal perspective was approximately MYR 32.5 billion, accounting for 3.83% of the 2012 Gross Domestic Product of the country. It would cost the nation MYR 18.3 billion to treat patients with moderate periodontitis and MYR 13.7 billion to treat patients with severe periodontitis. Conclusion. The economic burden of periodontitis in Malaysia is substantial and comparable with that of other chronic diseases in the country. This is attributable to its high prevalence and high cost of treatment. Judicious application of promotive, preventive, and curative approaches to periodontitis management is decidedly warranted.

  16. Disability weights for the Global Burden of Disease 2013 study

    NARCIS (Netherlands)

    Salomon, Joshua A.; Haagsma, Juanita A.; Davis, Adrian; de Noordhout, Charline Maertens; Polinder, Suzanne; Havelaar, Arie H.; Cassini, Alessandro; Devleesschauwer, Brecht; Kretzschmar, Mirjam; Speybroeck, Niko; Murray, Christopher J L; Vos, Theo

    2015-01-01

    Background: The Global Burden of Disease (GBD) study assesses health losses from diseases, injuries, and risk factors using disability-adjusted life-years, which need a set of disability weights to quantify health levels associated with non-fatal outcomes. The objective of this study was to estimate

  17. Disability weights for the Global Burden of Disease 2013 study

    NARCIS (Netherlands)

    Salomon, Joshua A; Haagsma, Juanita A; Davis, Adrian; de Noordhout, Charline Maertens; Polinder, Suzanne; Havelaar, Arie H; Cassini, Alessandro; Devleesschauwer, Brecht; Kretzschmar, MEE; Speybroeck, Niko; Murray, Christopher J L; Vos, Theo

    2015-01-01

    BACKGROUND: The Global Burden of Disease (GBD) study assesses health losses from diseases, injuries, and risk factors using disability-adjusted life-years, which need a set of disability weights to quantify health levels associated with non-fatal outcomes. The objective of this study was to estimate

  18. Disease burden of selected gastrointestinal pathogens in Australia, 2010

    Directory of Open Access Journals (Sweden)

    Katherine B. Gibney

    2014-11-01

    Conclusions: The pathogen causing the greatest disease burden varied according to the metric used, however DALYs are considered most useful given the incorporation of morbidity, mortality, and sequelae. These results can be used to prioritize public health interventions toward Salmonella and Campylobacter infections and to measure the impact of these interventions.

  19. Tax burden of chosen type of non-profit organization

    OpenAIRE

    HOSTIČKOVÁ, Jitka

    2011-01-01

    Nonprofit organizations are governed by the same tax rules as business organizations. There are different tax benefits and exemptions, but there are higher demands on accounting and tax records. The interpretation of tax law seems confusing and complicated, therefore it was suggested how to reduce the administrative burden of non-profit organization.

  20. Slope versus Elasticity and the Burden of Taxation.

    Science.gov (United States)

    Graves, Philip E.; And Others

    1996-01-01

    Criticizes the standard presentation, in introductory economics, of the burden of a tax as an application of elasticity. Argues that using the slopes of a supply and demand curve is the simplest and easiest way to clarify tax incidence. Includes three graphs illustrating this approach. (MJP)

  1. The Global Burden of Disease assessments--WHO is responsible?

    Directory of Open Access Journals (Sweden)

    Claudia Stein

    Full Text Available The Global Burden of Disease (GBD concept has been used by the World Health Organization (WHO for its reporting on health information for nearly 10 years. The GBD approach results in a single summary measure of morbidity, disability, and mortality, the so-called disability-adjusted life year (DALY. To ensure transparency and objectivity in the derivation of health information, WHO has been urged to use reference groups of external experts to estimate burden of disease. Under the leadership and coordination of WHO, expert groups have been appraising and abstracting burden of disease information. Examples include the Child Health Epidemiology Reference Group (CHERG, the Malaria Monitoring and Evaluation Reference Group (MERG, and the recently established Foodborne Disease Burden Epidemiology Reference Group (FERG. The structure and functioning of and lessons learnt by these groups are described in this paper. External WHO expert groups have provided independent scientific health information while operating under considerable differences in structure and functioning. Although it is not appropriate to devise a single "best practice" model, the common thread described by all groups is the necessity of WHO's leadership and coordination to ensure the provision and dissemination of health information that is to be globally accepted and valued.

  2. Sharing the burden of financing adaptation to climate change

    NARCIS (Netherlands)

    Dellink, R.; Elzen, M.; Aiking, H.; Bergsma, E.; Berkhout, F.; Dekker, T.; Gupta, J.

    2009-01-01

    Climate change may cause most harm to countries that have historically contributed the least to greenhouse gas emissions and land-use change. This paper identifies consequentialist and non-consequentialist ethical principles to guide a fair international burden-sharing scheme of climate change adapt

  3. Carotid plaque burden as a measure of subclinical atherosclerosis

    DEFF Research Database (Denmark)

    Sillesen, Henrik; Muntendam, Pieter; Adourian, Aram; Entrekin, Robert; Garcia, Mario; Falk, Erling; Fuster, Valentin

    2012-01-01

    The purpose of this study was to compare carotid plaque burden, carotid intima-media thickness (cIMT), ankle-brachial index (ABI), and abdominal aortic diameter (AAD) to coronary artery calcium score (CACS) in people without known cardiovascular disease....

  4. Global and regional burden of stroke during 1990-2010

    DEFF Research Database (Denmark)

    Feigin, Valery L; Forouzanfar, Mohammad H; Krishnamurthi, Rita;

    2014-01-01

    BACKGROUND: Although stroke is the second leading cause of death worldwide, no comprehensive and comparable assessment of incidence, prevalence, mortality, disability, and epidemiological trends has been estimated for most regions. We used data from the Global Burden of Diseases, Injuries, and Ri...

  5. WHO Initiative to Estimate the Global Burden of Foodborne Diseases

    DEFF Research Database (Denmark)

    Havelaar, Arie H.; Cawthorne, Amy; Angulo, Fred;

    2013-01-01

    BackgroundThe public health impact of foodborne diseases globally is unknown. The WHO Initiative to Estimate the Global Burden of Foodborne Diseases was launched out of the need to fill this data gap. It is anticipated that this effort will enable policy makers and other stakeholders to set appro...

  6. Otitis media across nine countries : Disease burden and management

    NARCIS (Netherlands)

    Arguedas, A.; Kvaerner, K.; Liese, J.; Schilder, A. G. M.; Pelton, S. I.

    2010-01-01

    Objective: To assess the perceived disease burden and management of otitis media (OM) among an international cohort of experienced physicians. Methods: A cross-sectional survey conducted in France, Germany, Spain, Poland, Argentina, Mexico, South Korea, Thailand and Saudi Arabia. Face-to-face interv

  7. The Hierarchical Clustering of Tax Burden in the EU27

    Directory of Open Access Journals (Sweden)

    Simkova Nikola

    2015-09-01

    Full Text Available The issue of taxation has become more important due to a significant share of the government revenue. There are several ways of expressing the tax burden of countries. This paper describes the traditional approach as a share of tax revenue to GDP which is applied to the total taxation and the capital taxation as a part of tax systems affecting investment decisions. The implicit tax rate on capital created by Eurostat also offers a possible explanation of the tax burden on capital, so its components are analysed in detail. This study uses one of the econometric methods called the hierarchical clustering. The data on which the clustering is based comprises countries in the EU27 for the period of 1995 – 2012. The aim of this paper is to reveal clusters of countries in the EU27 with similar tax burden or tax changes. The findings suggest that mainly newly acceding countries (2004 and 2007 are in a group of countries with a low tax burden which tried to encourage investors by favourable tax rates. On the other hand, there are mostly countries from the original EU15. Some clusters may be explained by similar historical development, geographic and demographic characteristics.

  8. Family Stigma and Caregiver Burden in Alzheimer's Disease

    Science.gov (United States)

    Werner, Perla; Mittelman, Mary S.; Goldstein, Dovrat; Heinik, Jeremia

    2012-01-01

    Purpose: The stigma experienced by the family members of an individual with a stigmatized illness is defined by 3 dimensions: caregiver stigma, lay public stigma, and structural stigma. Research in the area of mental illness suggests that caregivers' perception of stigma is associated with increased burden. However, the effect of stigma on…

  9. Body contact and body language

    DEFF Research Database (Denmark)

    Winther, Helle Dagmar

    2008-01-01

    and the boundaries between self and world. In western societies, the modern premises for contact are in some ways developing from close contact to virtual communication. With this breadth of perspective in mind, the ques­tion is whether conscious and experimental work with body contact and body language in move......­ment psychology and education provide potential for intense personal develop­ment as well as for social and cultural learning processes. This performative research project originates from the research project entitled, Movement Psy­chol­ogy: The Language of the Body and the Psy­chol­ogy of Movement based...... on the Dance Therapy Form Dansergia. The author, who is a practi­tioner-researcher, is methodologically inspir­ed by phenomenology, performative methods and a narrative and auto-ethnographic approach. The project will be presented in an organic, cre­at­ive and performative way. Through a moving dia...

  10. Body counter

    International Nuclear Information System (INIS)

    The paper gives a survey on some applications of the whole body counter in clinical practice and a critical study of its application as a routine testing method. Remarks on the necessary precautions are followed by a more detailed discussion of the determination of the natural potassium content, the iron metabolism, the vitamin B12 test, investigations of the metabolism of the bone using 47Ca and 85Sr, investigations with iodine and iodine-labelled substances, clearance investigations (in particular the 51Cr EDTA clearance test), as well as the possibilities of neutron activation in vivo. (ORU/AK)

  11. Body fluid identification in forensics

    Directory of Open Access Journals (Sweden)

    Ja Hyun An1, Kyoung-Jin Shin1,2, Woo Ick Yang1 & Hwan Young Lee1,2,*

    2012-10-01

    Full Text Available At a crime scene can give important insights into crime scenereconstruction by supporting a link between sample donorsand actual criminal acts. For more than a century, numeroustypes of body fluid identification methods have beendeveloped, such as chemical tests, immunological tests,protein catalytic activity tests, spectroscopic methods andmicroscopy. However, these conventional body fluididentification methods are mostly presumptive, and are carriedout for only one body fluid at a time. Therefore, the use of amolecular genetics-based approach using RNA profiling orDNA methylation detection has been recently proposed tosupplant conventional body fluid identification methods.Several RNA markers and tDMRs (tissue-specific differentiallymethylated regions which are specific to forensically relevantbody fluids have been identified, and their specificities andsensitivities have been tested using various samples. In thisreview, we provide an overview of the present knowledge andthe most recent developments in forensic body fluididentification and discuss its possible practical application toforensic casework.

  12. Religion and body weight in an underserved population

    Science.gov (United States)

    Religions prominence in some underserved groups that bear a disproportionate burden of the obesity epidemic (e.g. rural, Southern, minority) may play an important role in body weight. Data (1662 African American and Caucasian adults aged 18+) from a representative U.S. sample of a predominately rura...

  13. Comparing Cerebral White Matter Lesion Burdens between Parkinson’s Disease with and without Dementia

    Directory of Open Access Journals (Sweden)

    Sun-Ah Choi

    2010-05-01

    Full Text Available Cerebral white matter lesions (CWMLs have been suggested to be associated with an increased risk of dementia, disability, and death. CWMLs are more common in individuals with Alzheimer’s disease (AD than in normal elderly individuals of comparable age. Only a few studies have been done to determine whether CWMLs may influence cognitive decline in Parkinson’s disease (PD. Fully developed PD with concurrent AD was reported to likely cause impaired cognition in spite of accumulating evidence suggesting that PD with dementia (PDD is more closely associated with Lewy body (LB pathology. Currently, contradictory data on the neuropathology of dementia in PD require further prospective clinicopathological studies in larger cohorts to elucidate the impact of AD and α-synuclein (SCNA pathologies on the cognitive status in these disorders. Previous reports did not suggest CWMLs to be associated with an increased risk of PDD. After adjusting for age at death, age at onset of PD, and duration of PD, our recent study investigating CWMLs in PDD via autopsy has shown a positive correlation between the burden of CWMLs and PDD. The frequent co-existence of both LB and AD lesions suggests that both pathologies independently or synergistically contribute to both movement disorders and cognitive impairment. The individual and cumulative burden of CWMLs, LB lesions, and AD lesions may synergistically contribute to cognitive decline in LB disorders such as PDD.

  14. The personal, societal, and economic burden of schizophrenia in the People's Republic of China: implications for antipsychotic therapy

    Directory of Open Access Journals (Sweden)

    Montgomery W

    2013-08-01

    Full Text Available William Montgomery,1 Li Liu,2 Michael D Stensland,5 Hai Bo Xue,2 Tamas Treuer,4 Haya Ascher-Svanum31Eli Lilly and Company, Sydney, NSW, Australia; 2Lilly Suzhou Pharmaceutical Company, Ltd, Shanghai, People's Republic of China; 3Eli Lilly and Company, Global Health Outcomes, Indianapolis, IN, USA; 4Eli Lilly and Company, Budapest, Hungary; 5Agile Outcomes Research, Inc, Rochester, MN, USABackground: This article describes the personal, societal, and economic burden attributable to schizophrenia in the People's Republic of China and highlights the potential for effective outpatient treatment to reduce this burden given recent changes in the Chinese health care system. The importance of effective antipsychotic therapy in reducing the burden of schizophrenia is also examined.Methods: Published research on the burden, disability, management, and economic costs of schizophrenia in the People's Republic of China was examined in the context of the larger body of global research. Research written in English or Chinese and published before June 2012 was identified using PubMed, CNKI, and Wanfang Med database searches. The contribution of effective antipsychotic therapy in reducing the risk for relapse and hospitalization and improving patients' functioning is described.Results: Schizophrenia imposes a substantial burden on Chinese society, with indirect costs accounting for the majority of the total cost. Functional impairment is high, leading to lost wages and work impairment. In the People's Republic of China, schizophrenia is the most common diagnosis among hospitalized psychiatric patients. Ongoing changes in the Chinese health care system may reduce some barriers to effective relapse prevention in schizophrenia and potentially reduce hospitalizations. The use of antipsychotics for acute episodes and maintenance treatment has been shown to decrease symptom severity and reduce the risk for relapse and hospitalization. However, discontinuing

  15. Foreign Body Retrieval

    Science.gov (United States)

    ... News Physician Resources Professions Site Index A-Z Foreign Body Retrieval Foreign body retrieval is the removal ... of foreign body detection and removal? What is Foreign Body Retrieval? Foreign body retrieval involves the removal ...

  16. Chemical Emergencies

    Science.gov (United States)

    When a hazardous chemical has been released, it may harm people's health. Chemical releases can be unintentional, as in the case of an ... the case of a terrorist attack with a chemical weapon. Some hazardous chemicals have been developed by ...

  17. Radiation burden during renal scintigraphy with sup(99m)Tc-DMSA

    International Nuclear Information System (INIS)

    The radiation burden associated with renal scintigraphy using sup(99m)Tc-DMSA is shown up by use of data from the literature as well as of own data including a re-evaluation of the radiation dose. Kinetic data were obtained from six patients without kidney disease by measuring serum and urine activity. For calculation of the radiation doses the experimental data were fitted to pluricompartmental models in order to permit the calculation of the radiation doses according to the MIRD-method. The kidney cortex is the critical organ, with a radiation dose of 0.9 rd/mCi sup(99m)Tc-DMSA, the whole body radiation dose is calculated at 0.014 rd/mCisup(99m)Tc-DMSA. (orig.)

  18. Mercury (Hg) burden in children: The impact of dental amalgam

    Energy Technology Data Exchange (ETDEWEB)

    Al-Saleh, Iman, E-mail: iman@kfshrc.edu.sa [Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, PO Box: 3354, Riyadh 11211 (Saudi Arabia); Al-Sedairi, Al anoud [Department of Zoology, College of Science, King Saud University, PO Box: 24452, Riyadh 11495 (Saudi Arabia)

    2011-07-15

    The risks and benefits of using mercury (Hg) in dental amalgam have long been debated. This study was designed to estimate Hg body burden and its association with dental amalgam fillings in 182 children (ages: 5-15 years) living in Taif City. Hg was measured in urine (UHg), hair (HHg) and toenails (NHg) by the Atomic Absorption Spectrophotometer with Vapor Generator Accessory system. Urinary Hg levels were calculated as both micrograms per gram creatinine ({mu}g/g creatinine) and micrograms per liter ({mu}g/L). We found that children with amalgam fillings (N = 106) had significantly higher UHg-C levels than children without (N = 76), with means of 3.763 {mu}g/g creatinine versus 3.457 {mu}g/g creatinine, respectively (P = 0.019). The results were similar for UHg (P = 0.01). A similar pattern was also seen for HHg, with means of 0.614 {mu}g/g (N = 97) for children with amalgam versus 0.242 {mu}g/g (N = 74) for those without amalgam fillings (P = 0). Although the mean NHg was higher in children without amalgam (0.222 {mu}g/g, N = 61) versus those with (0.163 {mu}g/g, N = 101), the relationship was not significant (P = 0.069). After adjusting for many confounders, the multiple logistic regression model revealed that the levels of UHg-C and HHg were 2.047 and 5.396 times higher, respectively, in children with dental amalgam compared to those without (P < 0.01). In contrast, a significant inverse relationship was seen between NHg levels and dental amalgam fillings (P = 0.003). Despite the controversy surrounding the health impact of dental amalgam, this study showed some evidence that amalgam-associated Hg exposure might be related with symptoms of oral health, such as aphthous ulcer, white patches, and a burning-mouth sensation. Further studies are needed to reproduce these findings. The present study showed that significant numbers of children with or without amalgam had Hg levels exceeding the acceptable reference limits. The detrimental neurobehavioral and

  19. Mercury (Hg) burden in children: The impact of dental amalgam

    International Nuclear Information System (INIS)

    The risks and benefits of using mercury (Hg) in dental amalgam have long been debated. This study was designed to estimate Hg body burden and its association with dental amalgam fillings in 182 children (ages: 5-15 years) living in Taif City. Hg was measured in urine (UHg), hair (HHg) and toenails (NHg) by the Atomic Absorption Spectrophotometer with Vapor Generator Accessory system. Urinary Hg levels were calculated as both micrograms per gram creatinine (μg/g creatinine) and micrograms per liter (μg/L). We found that children with amalgam fillings (N = 106) had significantly higher UHg-C levels than children without (N = 76), with means of 3.763 μg/g creatinine versus 3.457 μg/g creatinine, respectively (P = 0.019). The results were similar for UHg (P = 0.01). A similar pattern was also seen for HHg, with means of 0.614 μg/g (N = 97) for children with amalgam versus 0.242 μg/g (N = 74) for those without amalgam fillings (P = 0). Although the mean NHg was higher in children without amalgam (0.222 μg/g, N = 61) versus those with (0.163 μg/g, N = 101), the relationship was not significant (P = 0.069). After adjusting for many confounders, the multiple logistic regression model revealed that the levels of UHg-C and HHg were 2.047 and 5.396 times higher, respectively, in children with dental amalgam compared to those without (P < 0.01). In contrast, a significant inverse relationship was seen between NHg levels and dental amalgam fillings (P = 0.003). Despite the controversy surrounding the health impact of dental amalgam, this study showed some evidence that amalgam-associated Hg exposure might be related with symptoms of oral health, such as aphthous ulcer, white patches, and a burning-mouth sensation. Further studies are needed to reproduce these findings. The present study showed that significant numbers of children with or without amalgam had Hg levels exceeding the acceptable reference limits. The detrimental neurobehavioral and/or nephrotoxic effects of

  20. National Burden of Eye Diseases in Iran, 1990–2010; Findings from the Global Burden of Diseases Study 2010

    Science.gov (United States)

    Hatef, Elham; Mohammadi, Seyed-Farzad; Alinia, Cyrus; Ashrafi, Elham; Mohammadi, S-Mehrdad; Lashay, Alireza; Sadeghi-Tari, Ali

    2016-01-01

    Purpose: The disability-adjusted life-years (DALYs) lost due to eye diseases and trends in DALYs in Iran has not been previously reported. The object of this study is to report the burden of eye diseases in Iran and to compare changes from 1990 to 2010 based on age and gender. Methods: Data from the Global Burden of Disease Study 2010 (GBD 2010) are used to report DALYs for cataract, refraction/accommodation (functional) disorders, macular degeneration, and glaucoma. Results: Cataract, refraction/accommodation (functional) disorders, macular degeneration, and glaucoma were the 84th, 87th, 138th, and 151st causes of DALY in 1990 and the 89th, 72nd, 99th, and 137th in 2010, respectively. Cataract accounted for 0.085% of national DALY in 1990 and 0.09% in 2010, refraction/accommodation (functional) disorders accounted for 0.42% in 1990 and 0.47% in 2010, macular degeneration accounted for 0.017% in 1990 and 0.071% in 2010 and glaucoma accounted for 0.0099% in 1990 and 0.025% in 2010. There was a steady increase in DALY with age for each eye disease for both genders and dichotomized for males and females from 1990 to 2010. Conclusions: Epidemiologic transition is reflected in major ophthalmic and blinding diseases in the GBD data for Iran. The burden of macular degeneration is rising, followed by glaucoma. The burden of presbyopia affected individuals past their middle age. The burden of cataract manifested as a slower increase that could be attributable to better access to treatment. PMID:26957846

  1. Housing as a Social Determinant of Health: Exploring the Relationship between Rent Burden and Risk Behaviors for Single Room Occupancy Building Residents.

    Science.gov (United States)

    Bowen, Elizabeth A; Mitchell, Christopher G

    2016-01-01

    A growing body of health determinants research recognizes that housing and health are intimately linked. This study explores the relationship between rent burden (the ratio of rent to income) and health risk behaviors among a sample of single room occupancy (SRO) building residents. Cross-sectional data were gathered from a sample of 162 residents living in privately owned, for-profit SROs in Chicago. Findings indicated that participants who had full rental subsidies and thus were designated in a no-rent-burden category were more likely to engage in risk behaviors including illicit drug use, having multiple sexual partners, and having sex without a condom, in comparison to participants with moderate or high-rent burdens. These findings suggest that interventions to increase housing stability and affordability and bolster reliable income sources (in addition to rental subsidies) may be key in reducing risk behaviors and improving health for vulnerably housed populations such as SRO residents. PMID:27167535

  2. Computational Systems Chemical Biology

    OpenAIRE

    Oprea, Tudor I.; May, Elebeoba E.; Leitão, Andrei; Tropsha, Alexander

    2011-01-01

    There is a critical need for improving the level of chemistry awareness in systems biology. The data and information related to modulation of genes and proteins by small molecules continue to accumulate at the same time as simulation tools in systems biology and whole body physiologically-based pharmacokinetics (PBPK) continue to evolve. We called this emerging area at the interface between chemical biology and systems biology systems chemical biology, SCB (Oprea et al., 2007).

  3. Environmental chemicals in human milk: a review of levels, infant exposures and health, and guidance for future research

    International Nuclear Information System (INIS)

    The aim of this review is to introduce the reader to various science and policy aspects of the topic of environmental chemicals in human milk. Although information on environmental chemicals in human milk has been available since the 1950s, it is only relatively recently that public awareness of the issue has grown. This review on environmental chemicals in human milk provides a resource summarizing what is currently known about levels and trends of environmental chemicals in human milk, potential infant exposures, and benefits of breast-feeding relative to the risks of exposures to environmental chemicals. The term 'environmental chemicals', as it pertains to human milk, refers to many classes of exogenous chemicals that may be detected in human milk. For example, pharmaceutical agents and alcohol are environmental chemicals that have been found in human milk. Other chemicals, such as heavy metals and volatile organic compounds, have also been detected in human milk. Most research on environmental chemicals in human milk has concentrated on persistent, bioaccumulative, and toxic (PBT) chemicals. In this review, a description of human milk is provided, including a brief review of endogenous substances in human milk. Determinants of levels of PBTs are discussed, as are models that have been developed to predict levels of PBTs in human milk and associated body burdens in breast-feeding infants. Methodologies for human milk sampling and analysis, and concepts for consideration in interpretation and communication of study results, as developed by the Technical Workshop on Human Milk Surveillance and Research for Environmental Chemicals in the United States are described. Studies which have compared the health risks and benefits associated with breast-feeding and formula-feeding are discussed

  4. The burden of pulmonary hypertension in resource-limited settings.

    Science.gov (United States)

    Gidwani, Suman; Nair, Ajith

    2014-09-01

    Pulmonary vascular disease (PVD) is a significant global health problem and accounts for a substantial portion of cardiovascular disease in the developing world. Although there have been considerable advances in therapeutics for pulmonary arterial hypertension, over 97% of the disease burden lies within the developing world where there is limited access to health care and pharmaceuticals. The causes of pulmonary arterial hypertension differ between industrialized and developing nations. Infectious diseases-including schistosomiasis human immunodeficiency virus, and rheumatic fever-are common causes of PVD, as are hemoglobinopathies, and untreated congenital heart disease. High altitude and exposure to household air pollutants also contribute to a significant portion of PVD cases. Although diagnosis of pulmonary arterial hypertension requires the use of imaging and invasive hemodynamics, access to equipment may be limited. PVD therapies may be prohibitively expensive and limited to a select few. Prevention is therefore important in limiting the global PVD burden. PMID:25667181

  5. Dietary burden calculations relating to fish metabolism studies.

    Science.gov (United States)

    Schlechtriem, Christian; Pucher, Johannes; Michalski, Britta

    2016-03-30

    Fish farming is increasingly dependent on plant commodities as a source of feed leading to an increased risk for pesticide residues in aquaculture diets and consequently their transfer into aquaculture food products. The European pesticide regulation requires fish metabolism and fish feeding studies where residues in fish feed exceed 0.1 mg kg(-1) of the total diet (dry weight basis) to enable the setting of appropriate maximum residue levels in fish commodities. Fish dietary burden calculation is therefore an important prerequisite to decide on further experimental testing as part of the consumer risk assessment. In this review, the different aquaculture production systems are compared with regard to their specific feeding practices and the principles of dietary burden calculation are described. PMID:26749492

  6. The alteration of the BPM, burden neutrality and autonomous greening

    International Nuclear Information System (INIS)

    The foundation of the purchase tax on passenger cars (BPM) in the Netherlands is gradually altered from catalogue value to CO2 emission per kilometer of the new car. The tariffs have been established in such a way that they meet the precondition of burden neutrality of the BPM alteration. There is some discussion about this and the first part of this publication will address this issue. The issue of burden neutrality is part of a study by DHV Investment Services (DHV). The first main conclusion of the DHV study is that the alteration is not budget neutral. The study entails an applied welfare analysis of the alteration of the BPM foundation. Some comments on the welfare analysis are provided in the second part of this memo. Another issue that is addressed involves the question if and how the autonomous decrease in CO2 emission of newly sold cars can be established in practice.

  7. Alcohol-attributed disease burden in four Nordic countries

    DEFF Research Database (Denmark)

    Agardh, Emilie E; Danielsson, Anna-Karin; Ramstedt, Mats;

    2016-01-01

    AIMS: To compare alcohol-attributed disease burden in four Nordic countries 1990-2013, by overall disability adjusted life years (DALYs), and separated by premature mortality (YLL), and health loss to non-fatal conditions (YLD), 2) to examine whether changes in alcohol consumption informs alcohol...... Finland, changes in consumption generally corresponded to changes in disease burden, but not to the same extent in Sweden and Norway. All countries had a similar disease pattern and the majority of DALYs were due to YLLs (62-76%), mainly from alcohol use disorder, cirrhosis, transport injuries, self...... consumption levels in general corresponded to changes in harm in Finland and Denmark, but not in Sweden and Norway for some years. All countries followed a similar pattern. The majority of disability-adjusted life years were due to premature mortality. Alcohol use disorder by non-fatal conditions accounted...

  8. A double burden of overall or central adiposity and anemia or iron deficiency is prevalent but with little socioeconomic patterning among Moroccan and Tunisian urban women.

    Science.gov (United States)

    Gartner, Agnès; El Ati, Jalila; Traissac, Pierre; Bour, Abdellatif; Berger, Jacques; Landais, Edwige; El Hsaïni, Houda; Ben Rayana, Chiheb; Delpeuch, Francis

    2014-01-01

    In North Africa, overnutrition has dramatically increased with the nutrition transition while micronutrient deficiencies persist, resulting in clustering of opposite types of malnutrition that can present a unique difficulty for public health interventions. We assessed the magnitude of the double burden of malnutrition among urban Moroccan and Tunisian women, as defined by the coexistence of overall or central adiposity and anemia or iron deficiency (ID), and explored the sociodemographic patterning of individual double burden. In cross-sectional surveys representative of the region around the capital city, we randomly selected 811 and 1689 nonpregnant women aged 20-49 y in Morocco and Tunisia, respectively. Four double burdens were analyzed: overweight (body mass index ≥25 kg/m(2)) or increased risk abdominal obesity (waist circumference ≥80 cm) and anemia (blood hemoglobin education groups. Generally, the rare, associated sociodemographic factors varied across the 4 subject-level double burdens and the 2 countries and differed from those usually associated with adiposity, anemia, or ID. Any double burden combining adiposity and anemia or ID should therefore be taken into consideration in all women. This trial was registered at clinicaltrials.gov as NCT01844349. PMID:24198310

  9. Regional pattern of cardiovascular risk burden in Croatia

    OpenAIRE

    KERN, JOSIPA; Polašek, Ozren; Musić Milanović, Sanja; Džakula, Aleksandar; Fišter, Kristina; Strnad, Marija; Ivanković, Davor; Vuletić, Silvije

    2009-01-01

    The objective of this study was to investigate regional gradient of a synthetic cardiovascular burden (CVRB) in Croatia. Analysis was based on a multistage stratified sample representative of general adult population in six regions of Croatia (Croatian Adult Health Survey). Synthetic CVRB was defined by incidents (heart attack, stroke), blood pressure, overweight/obesity (BMI, waist circumference), and risky behaviours (smoking, physical inactivity, high alcohol consumption, inadequate nutrit...

  10. The bismuth burden - a challenge for the accident insurance (Berufsgenossenschaften)

    International Nuclear Information System (INIS)

    The Soviet-German Bismuth AG was a state within a state in the former GDR. Uranium mining not only caused great ecological burdens but also gave rise to many problems for the accident insurance. Occupational diseases are of course, very important in the context of malignous growth caused by ionised radiation. The accident insurances (Berufsgenossenschaften) recognised the size of this unique problem and have initiated measures towards its solution. (orig.)

  11. Graphic representation of the burden of suffering in dizziness patients

    OpenAIRE

    Weidt, Steffi; Bruehl, Annette Beatrix; Moergeli, Hanspeter; Straumann, Dominik; Hegemann, Stefan; Büchi, Stefan; Rufer, Michael

    2014-01-01

    Background Dizziness adversely affects an individual’s well-being. However, its impact is not only influenced by its physical manifestations, but also by its subjective importance to the patient. Appropriately assessing the subjective burden of dizziness is difficult. The Pictorial-Representation of Illness- and Self-Measure (PRISM), on which patients illustrate the distance between their ‘self’ and their illness, has been documented to indicate the perception of suffering in several differen...

  12. Tax Burden and Migration: A Political Economy Perspective

    OpenAIRE

    Assaf Razin; Efraim Sadka

    1996-01-01

    The extent of taxation and redistribution policy is generally determined at a political-economy equilibrium by a balance between those who gain and those who lose from a more extensive tax-transfer policy. In a stylized model of migration and human capital formation we find, somewhat against conventional wisdom, that low-skill migration may lead to a lower tax burden and less redistribution than without migration, even though the migrants (naturally) join the pro-tax cum transfer coalition.

  13. New classification scheme for atrial fibrillation symptom severity and burden.

    Science.gov (United States)

    Koci, Florian; Forbes, Peter; Mansour, Moussa C; Heist, E Kevin; Singh, Jagmeet P; Ellinor, Patrick T; Ruskin, Jeremy N

    2014-07-15

    Although atrial fibrillation (AF) symptom severity is used to guide clinical care, a simple, standardized assessment tool is not available for routine clinical use. We sought to develop and validate a patient-generated score and classification scheme for AF-related symptom severity and burden. Atrial Fibrillation Symptom and Burden, a simple 2-part questionnaire, was designed to assess (1) AF symptom severity using 8 questions to determine how symptoms affect daily life and (2) AF burden using 6 questions to measure AF frequency, duration, and health-care utilization. The resulting score was used to classify patients into 4 classes of symptom and burden severity. Patients were asked to complete the questionnaire, a survey evaluating the questionnaire, and an Short Form-12v2 generic health-related quality-of-life form. Validation of the questionnaire included assessments of its reliability and construct and known groups validity. The strength of interrater agreement between patient-generated and blinded provider-generated classifications of AF symptom severity was also assessed. The survey had good internal consistency (Cronbach α>0.82) and reproducibility (intraclass correlation coefficient=0.93). There was a good linear correlation with health-related quality-of-life aggregates measured by Pearson correlation coefficient (r=0.62 and 0.42 vs physical component summary and mental component summary, respectively). Compared with physical and mental component summary scores, the patient-generated symptom severity classification scheme showed robust discrimination between mild and moderate severity (pcorrelated with standardized quality-of-life measures. PMID:24878121

  14. Melanoma Surveillance in the US: The Economic Burden of Melanoma

    Centers for Disease Control (CDC) Podcasts

    2011-10-19

    This podcast accompanies the publication of a series of articles on melanoma surveillance in the United States, available in the November supplement edition of the Journal of the American Academy of Dermatology. Dr. Gery Guy, from the CDC’s Division of Cancer Prevention and Control, discusses the economic burden of melanoma.  Created: 10/19/2011 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 10/19/2011.

  15. Financial burden of hospitalisation for child abuse in Hong Kong

    OpenAIRE

    Tsang, Man-Ching; 曾文正

    2013-01-01

    Child abuse is a well-known child care problem. Classically, there are four main types of abuse: physical, sexual and emotional abuse, and neglect. The incidence is often underestimated because a number of cases are not severe enough for caregivers to seek medical help. However, the more severe forms of child abuse can lead to significant morbidity and even mortality. Many studies have addressed the characteristics and outcomes of child abuse. However, the financial burden of child abuse that...

  16. Cadmium burden and the risk and phenotype of prostate cancer

    OpenAIRE

    Wu Tony T; Wu Hsi-Chin; Pu Yeong S; Chen Yi-Chun; Lai Ming; Yang Chun Y; Sung Fung-Chang

    2009-01-01

    Abstract Background Studies on the association between prostate cancer and cadmium exposure have yielded conflicting results. This study explored cadmium burden on the risk and phenotype of prostate cancer in men with no evident environmental exposure. Methods Hospital-based 261 prostate cancer cases and 267 controls with benign diseases were recruited from four hospitals in Taiwan. Demographic, dietary and lifestyle data were collected by standardized questionnaires. Blood cadmium (BCd) and ...

  17. Tax burden of businessmen during tax filling and accounts keeping

    OpenAIRE

    Špačková, Markéta

    2012-01-01

    This work is about tax burden of entrepreneurs during tax filling and bookkeeping. There are defined first the key words, main diferences between tax evidence and bookkeeping. There are incomes and expenses in tax evidence according to the real time when they are received or payed. In bookkeeping there are accounted revenues and costs according to the chart of accounts regardless of the time of payment. That means that the tax base may be diverse. Tax base is difference between incomes and ex...

  18. Estimating the Global Burden of Endemic Canine Rabies

    OpenAIRE

    Hampson, Katie; Coudeville, Laurent; Lembo, Tiziana; Sambo, Maganga; Kieffer, Alexia; Attlan, Michaël; Barrat, Jacques; Blanton, Jesse D.; Briggs, Deborah J.; Cleaveland, Sarah; Costa, Peter; Freuling, Conrad M.; Hiby, Elly; Knopf, Lea; Leanes, Fernando

    2015-01-01

    Background: Rabies is a notoriously underreported and neglected disease of lowincome countries. This study aims to estimate the public health and economic burden of rabies circulating in domestic dog populations, globally and on a country-by-country basis, allowing an objective assessment of how much this preventable disease costs endemic countries. Methodology/Principal Findings: We established relationships between rabies mortality and rabies prevention and control measure...

  19. A neurodegenerative vascular burden index and the impact on cognition

    Directory of Open Access Journals (Sweden)

    Sebastian Heinzel

    2014-07-01

    Full Text Available A wide range of vascular burden factors have been identified to impact vascular function and structure as indicated by carotid intima-media thickness (IMT. On the basis of their impact on IMT, vascular factors may be selected and clustered in a vascular burden index (VBI. Since many vascular factors increase the risk of Alzheimer's disease (AD, a multifactorial neurodegenerative VBI may be related to early pathological processes in AD and cognitive decline in its preclinical stages.We investigated an elderly cohort at risk for neurodegeneration (TREND study, n = 1102 for the multifactorial influence of vascular burden factors on IMT measured by ultrasound. To create a VBI for this cohort, vascular factors and their definitions (considering medical history, medication and/or blood marker data were selected based on their statistical effects on IMT in multiple regressions including age and sex. The impact of the VBI on cognitive performance was assessed using the Trail-Making Test (TMT and the CERAD neuropsychological battery.IMT was significantly predicted by age (standardized β = .26, sex (.09; males > females and the factors included in the VBI: obesity (.18, hypertension (.14, smoking (.08, diabetes (.07, and atherosclerosis (.05, whereas other cardiovascular diseases or hypercholesterolemia were not significant. Individuals with 2 or more VBI factors compared to individuals without had an odds ratio of 3.17 regarding overly increased IMT (≥1.0 mm. The VBI showed an impact on executive control (log(TMT B-A, p = .047 and a trend towards decreased global cognitive function (CERAD total score, p = .057 independent of age, sex and education.A VBI established on the basis of IMT may help to identify individuals with overly increased vascular burden linked to decreased cognitive function indicating neurodegenerative processes. The longitudinal study of this risk cohort will reveal the value of the VBI as prodromal marker for cognitive decline and

  20. The ordinary consumer: the burden of economic sanctions against Russia

    OpenAIRE

    Nureev Rustem, M.; Petrakov Pavel, K.

    2015-01-01

    The main thrust of the paper - an attempt to assess how much the sanctions combined with the drop in oil prices hit the consumers. This paper provides an overview of the sanctions imposed by European Union, the United States and other countries (ban largest organizations in Russia to attract foreign capital of the European Union and the United States). The burden of economic sanctions against Russia for the average consumer is shown on the change in prices for food products, electronic produc...

  1. The Burden of Livestock Parasites on the Poor.

    Science.gov (United States)

    Rist, Cassidy L; Garchitorena, Andres; Ngonghala, Calistus N; Gillespie, Thomas R; Bonds, Matthew H

    2015-11-01

    Parasitic diseases of humans and livestock are ubiquitous in the developing world and have substantial impacts on human wellbeing. For the estimated one billion people living in poverty who rely on livestock for their livelihoods, parasites steal valuable nutritional resources through multiple pathways. This diversion of nutrients ultimately contributes to chronic malnutrition, greater human disease burdens, and decreased productivity of both humans and livestock. PMID:26604161

  2. HOW TO MOTIVATE ENGLISH LEARNERS FACED WITH PSYCHOLOGICAL BURDEN

    Directory of Open Access Journals (Sweden)

    Himpun Panggabean

    2007-01-01

    Full Text Available The misleading assumptions of Indonesian-speaking learners of English on the nature of English results in psychological burden inhibiting the process of teaching and learning. The assumptions should be eliminated at the beginning of English class. Besides, the instructor should extensively motivate and encourage the learners to maximize their potentials in learning process. Such approach will gradually lead the learners to self-confidence and self-discovery.

  3. The Burden of Migraine in Spain: Beyond Direct Costs

    OpenAIRE

    Xavier Badia; Sol Magaz; Laura Gutierrez; Jordi Galvan

    2004-01-01

    Objective: To estimate the economic burden of migraine in Spain, from the societal perspective. Methods: The Spanish 2001 annual direct (pharmacy, primary care, specialist and emergency room visits) and indirect (missed workdays and reduced work performance) costs were calculated using the prevalence approach. The human-capital method was used to calculate indirect costs. The sources used were published epidemiological and resource use studies using the International Headache Society diagnost...

  4. ANALYSIS OF ADMINISTRATIVE BURDENS FOR COMPANIES IN SELECTED SEE COUNTRIES

    OpenAIRE

    Bradač Hojnik, Barbara; Rebernik, Miroslav

    2011-01-01

    The institutional framework in which companies have to act establishes the rules of the game. It is limited and controlled by a public administration system, which may be more or less open and contemporary for companies. The aim of this paper is to analyse administrative procedures and costs for companies when dealing with public administration from a theoretical and empirical point of view. The paper’s goals are to compare administrative burdens and to find the advantages and...

  5. The Fiscal Burden of Korean Reunification: A Generational Accounting Approach

    OpenAIRE

    Alan J. Auerbach; Young Jun Chun; Ilho Yoo

    2004-01-01

    This paper uses Generational Accounting to assess the fiscal impacts of Korean reunification. Our findings suggest that early reunification will result in a large increase in the fiscal burden for most current and future generations of South Koreans. The Korean reunification's fiscal impact appears much larger than that of German reunification, due to a wider gap in productivity between the two Koreas and North Korea's much larger share of the unified country's population. The projected large...

  6. The Economic Burden of Inflammatory Heart Disease in Korea

    OpenAIRE

    Ko, Seul-Ki; Yoon, Seok-Jun; Oh, In-Hwan; Seo, Hye-Young; Kim, Eun-Jung

    2011-01-01

    Background and Objectives The incidence of inflammatory heart diseases is not yet as high as those of other cardiovascular diseases; however, inflammatory heart diseases do have relatively high mortality rate. Therefore, update information on the economic burden of inflammatory heart diseases are necessary in order to appropriate policy making on these diseases. Materials and Methods This study used a number of resources to obtain data, national health insurance statistics, the Korean Health ...

  7. Quantitative Analysis of Tumor Burden in Mouse Lung via MRI

    OpenAIRE

    Tidwell, Vanessa K.; Garbow, Joel R.; Krupnick, Alexander S.; Engelbach, John A.; Nehorai, Arye

    2011-01-01

    Lung cancer is the leading cause of cancer death in the United States. Despite recent advances in screening protocols, the majority of patients still present with advanced or disseminated disease. Pre-clinical rodent models provide a unique opportunity to test novel therapeutic drugs for targeting lung cancer. Respiratory-gated MRI is a key tool for quantitatively measuring lung-tumor burden and monitoring the time-course progression of individual tumors in mouse models of primary and metasta...

  8. One world health: socioeconomic burden and parasitic disease control priorities.

    Science.gov (United States)

    Torgerson, Paul R

    2013-08-01

    Parasitic diseases present a considerable socio-economic impact to society. Zoonotic parasites can result in a considerable burden of disease in people and substantive economic losses to livestock populations. Ameliorating the effects of these diseases may consist of attempts at eradicating specific diseases at a global level, eliminating them at a national or local level or controlling them to minimise incidence. Alternatively with some parasitic zoonoses it may only be possible to treat human and animal cases as they arise. The choice of approach will be determined by the potential effectiveness of a disease control programme, its cost and the cost effectiveness or cost benefit of undertaking the intervention. Furthermore human disease burden is being increasingly measured by egalitarian non-financial measures which are difficult to apply to livestock. This adds additional challenges to the assessment of socio-economic burdens of zoonotic diseases. Using examples from the group of neglected zoonotic diseases, information regarding the socio-economic effects is reviewed together with how this information is used in decision making with regard to disease control and treatment. PMID:23628712

  9. Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis

    Directory of Open Access Journals (Sweden)

    Mitra Khumbatta

    2014-01-01

    Full Text Available Cysticercosis is an infection of tissues with the larval cysts of the cestode, Taenia  solium. While live parasites elicit little or no inflammation, dying parasites initiate a granulomatous reaction presenting as painful muscle nodules or seizures when cysts are located in the brain. We previously showed in the T. crassiceps murine model of cysticercosis that substance P (SP, a neuropeptide, was detected in early granulomas and was responsible for promoting granuloma formation, while somatostatin (SOM, another neuropeptide and immunomodulatory hormone, was detected in late granulomas; SOM’s contribution to granuloma formation was not examined. In the current studies, we used somatostatin knockout (SOM−/− mice to examine the hypothesis that SOM downmodulates granulomatous inflammation in cysticercosis, thereby promoting parasite growth. Our results demonstrated that parasite burden was reduced 5.9-fold in SOM−/− mice compared to WT mice (P<0.05. This reduction in parasite burden in SOM−/− mice was accompanied by a 95% increase in size of their granulomas (P<0.05, which contained a 1.5-fold increase in levels of IFN-γ and a 26-fold decrease in levels of IL-1β (P<0.05 for both compared to granulomas from WT mice. Thus, SOM regulates both parasite burden and granulomatous inflammation perhaps through modulating granuloma production of IFN-γ and IL-1β.

  10. Burden sharing in the implementation of the Climate Convention

    International Nuclear Information System (INIS)

    Burden sharing in the actions needed to reduce greenhouse gas emissions has proved so far to be the most intractable problem in the implementation of the Climate Convention and the Kyoto Protocol. We analyzed the contribution of non-Annex I countries to the GHG emissions in the period 1850–2010 to assess their relative contribution to total GHG emissions. In the period 1850–1990 non-Annex I countries represented 44% of the total but this contribution increased in the period 1990–2010 to 56%. If we extrapolate present trends to 2030 they will represent 69% in the period 1990–2030. The “historical responsibility” of Annex I countries is therefore decreasing. If we take 1990 as the starting year in which the Climate Convention recognized clearly that greenhouse gases are interfering dangerously with the climate system, it is evident the need of non-Annex I countries to engage with Annex I countries in the effort to reduce emissions. We present three options for the burden sharing in such effort. -- Highlights: •Implementation of the Kyoto Protocol did not reduce global GHG emissions growth. •Defining burden sharing of emissions is key to the success of climate negotiations. •Accounting for historical emissions involves too many uncertainties. •Developed countries have already presented pledges to reduce their emissions by 2020. •Emissions of developing countries became dominant and they must act to reduce them

  11. The burden of non-communicable diseases in South Africa.

    Science.gov (United States)

    Mayosi, Bongani M; Flisher, Alan J; Lalloo, Umesh G; Sitas, Freddy; Tollman, Stephen M; Bradshaw, Debbie

    2009-09-12

    15 years after its first democratic election, South Africa is in the midst of a profound health transition that is characterised by a quadruple burden of communicable, non-communicable, perinatal and maternal, and injury-related disorders. Non-communicable diseases are emerging in both rural and urban areas, most prominently in poor people living in urban settings, and are resulting in increasing pressure on acute and chronic health-care services. Major factors include demographic change leading to a rise in the proportion of people older than 60 years, despite the negative effect of HIV/AIDS on life expectancy. The burden of these diseases will probably increase as the roll-out of antiretroviral therapy takes effect and reduces mortality from HIV/AIDS. The scale of the challenge posed by the combined and growing burden of HIV/AIDS and non-communicable diseases demands an extraordinary response that South Africa is well able to provide. Concerted action is needed to strengthen the district-based primary health-care system, to integrate the care of chronic diseases and management of risk factors, to develop a national surveillance system, and to apply interventions of proven cost-effectiveness in the primary and secondary prevention of such diseases within populations and health services. We urge the launching of a national initiative to establish sites of service excellence in urban and rural settings throughout South Africa to trial, assess, and implement integrated care interventions for chronic infectious and non-communicable diseases. PMID:19709736

  12. Drug Burden Index in older adults: theoretical and practical issues

    Directory of Open Access Journals (Sweden)

    Kouladjian L

    2014-09-01

    Full Text Available Lisa Kouladjian,1 Danijela Gnjidic,1,2 Timothy F Chen,2 Arduino A Mangoni,3 Sarah N Hilmer1 1Sydney Medical School, University of Sydney, Kolling Institute of Medical Research and Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, 2Faculty of Pharmacy, University of Sydney, Sydney, NSW, 3Department of Clinical Pharmacology, School of Medicine, Flinders University and Flinders Medical Centre, Bedford Park, SA, Australia Abstract: Anticholinergic and sedative medications are commonly used in older adults and are associated with adverse clinical outcomes. The Drug Burden Index was developed to measure the cumulative exposure to these medications in older adults and its impact on physical and cognitive function. This narrative review discusses the research and clinical applications of the Drug Burden Index, and its advantages and limitations, compared with other pharmacologically developed measures of high-risk prescribing. Keywords: Drug Burden Index, anticholinergics, sedative medications, high-risk prescribing, older adults, pharmacological risk assessment tools, deprescribing

  13. Hepatitis C virus infection in Argentina: Burden of chronic disease

    Science.gov (United States)

    Ridruejo, Ezequiel; Bessone, Fernando; Daruich, Jorge R; Estes, Chris; Gadano, Adrián C; Razavi, Homie; Villamil, Federico G; Silva, Marcelo O

    2016-01-01

    AIM: To estimate the progression of the hepatitis C virus (HCV) epidemic and measure the burden of HCV-related morbidity and mortality. METHODS: Age- and gender-defined cohorts were used to follow the viremic population in Argentina and estimate HCV incidence, prevalence, hepatic complications, and mortality. The relative impact of two scenarios on HCV-related outcomes was assessed: (1) increased sustained virologic response (SVR); and (2) increased SVR and treatment. RESULTS: Under scenario 1, SVR raised to 85%-95% in 2016. Compared to the base case scenario, there was a 0.3% reduction in prevalent cases and liver-related deaths by 2030. Given low treatment rates, cases of hepatocellular carcinoma and decompensated cirrhosis decreased < 1%, in contrast to the base case in 2030. Under scenario 2, the same increases in SVR were modeled, with gradual increases in the annual diagnosed and treated populations. This scenario decreased prevalent infections 45%, liver-related deaths 55%, liver cancer cases 60%, and decompensated cirrhosis 55%, as compared to the base case by 2030. CONCLUSION: In Argentina, cases of end stage liver disease and liver-related deaths due to HCV are still growing, while its prevalence is decreasing. Increasing in SVR rates is not enough, and increasing in the number of patients diagnosed and candidates for treatment is needed to reduce the HCV disease burden. Based on this scenario, strategies to increase diagnosis and treatment uptake must be developed to reduce HCV burden in Argentina.

  14. Cost and disease burden of Dengue in Cambodia

    Directory of Open Access Journals (Sweden)

    Beauté Julien

    2010-08-01

    Full Text Available Abstract Background Dengue is endemic in Cambodia (pop. estimates 14.4 million, a country with poor health and economic indicators. Disease burden estimates help decision makers in setting priorities. Using recent estimates of dengue incidence in Cambodia, we estimated the cost of dengue and its burden using disability adjusted life years (DALYs. Methods Recent population-based cohort data were used to calculate direct and productive costs, and DALYs. Health seeking behaviors were taken into account in cost estimates. Specific age group incidence estimates were used in DALYs calculation. Results The mean cost per dengue case varied from US$36 - $75 over 2006-2008 respectively, resulting in an overall annual cost from US$3,327,284 in 2008 to US$14,429,513 during a large epidemic in 2007. Patients sustain the highest share of costs by paying an average of 78% of total costs and 63% of direct medical costs. DALY rates per 100,000 individuals ranged from 24.3 to 100.6 in 2007-2008 with 80% on average due to premature mortality. Conclusion Our analysis confirmed the high societal and individual family burden of dengue. Total costs represented between 0.03 and 0.17% of Gross Domestic Product. Health seeking behavior has a major impact on costs. The more accurate estimate used in this study will better allow decision makers to account for dengue costs particularly among the poor when balancing the benefits of introducing a potentially effective dengue vaccine.

  15. Study of factors determining caregiver burden among primary caregivers of patients with intracranial tumors

    Directory of Open Access Journals (Sweden)

    Manju Dhandapani

    2015-01-01

    Conclusions: Behavioral changes in patients (especially irritability and financial constraints had a significant independent impact on the burden experienced by primary caregivers of patients operated for intracranial tumors. Identifying and managing, these are essential for reducing caregiver burden.

  16. STUDY ON SOFTENING AND DROPPING PROPERTIES OF METALIZED BURDEN INSIDE BLAST FURNACE

    Directory of Open Access Journals (Sweden)

    Bi-yang Tuo

    2014-12-01

    Full Text Available The inferences of burden metallization rate on softening-melting dropping properties were investigated through softening-melting dropping test of three kinds of metalized burden pressure drop. The results indicated that the softeningmelting temperature interval of pre-reduction mixed burden is bigger than primeval mixed burden, the melting interval narrow with the rise of metallization rate of ferric burden as well as dropping temperature interval. The average pressure drop, maximum pressure drop and softening-melting dropping properties eigenvalue decrease with the rise of metallization rate of ferric burden. Besides, the dropping temperature of burden reduces with the rise of carbon content of molten iron. The combination high metalized burden and higher carbon content of molten iron is benefit to decreasing thickness of cohesive zone and improve permeability of cohesive zone.

  17. Economic Burden for Informal Caregivers of Lung and Colorectal Cancer Patients

    OpenAIRE

    Van Houtven, Courtney Harold; Ramsey, Scott D; Hornbrook, Mark C.; Atienza, Audie A.; van Ryn, Michelle

    2010-01-01

    This study quantified the economic burden for informal caregivers of lung cancer and colorectal cancer patients, by cancer type, phase of disease, stage at diagnosis, patient age, and relationship, and found this burden to be substantial.

  18. The global burden of mental, neurological and substance use disorders: an analysis from the Global Burden of Disease Study 2010.

    Directory of Open Access Journals (Sweden)

    Harvey A Whiteford

    Full Text Available The Global Burden of Disease Study 2010 (GBD 2010, estimated that a substantial proportion of the world's disease burden came from mental, neurological and substance use disorders. In this paper, we used GBD 2010 data to investigate time, year, region and age specific trends in burden due to mental, neurological and substance use disorders.For each disorder, prevalence data were assembled from systematic literature reviews. DisMod-MR, a Bayesian meta-regression tool, was used to model prevalence by country, region, age, sex and year. Prevalence data were combined with disability weights derived from survey data to estimate years lived with disability (YLDs. Years lost to premature mortality (YLLs were estimated by multiplying deaths occurring as a result of a given disorder by the reference standard life expectancy at the age death occurred. Disability-adjusted life years (DALYs were computed as the sum of YLDs and YLLs.In 2010, mental, neurological and substance use disorders accounted for 10.4% of global DALYs, 2.3% of global YLLs and, 28.5% of global YLDs, making them the leading cause of YLDs. Mental disorders accounted for the largest proportion of DALYs (56.7%, followed by neurological disorders (28.6% and substance use disorders (14.7%. DALYs peaked in early adulthood for mental and substance use disorders but were more consistent across age for neurological disorders. Females accounted for more DALYs in all mental and neurological disorders, except for mental disorders occurring in childhood, schizophrenia, substance use disorders, Parkinson's disease and epilepsy where males accounted for more DALYs. Overall DALYs were highest in Eastern Europe/Central Asia and lowest in East Asia/the Pacific.Mental, neurological and substance use disorders contribute to a significant proportion of disease burden. Health systems can respond by implementing established, cost effective interventions, or by supporting the research necessary to develop

  19. Methodological Framework for World Health Organization Estimates of the Global Burden of Foodborne Disease

    OpenAIRE

    Devleesschauwer, Brecht; Haagsma, Juanita; Angulo, Frederick; Bellinger, David; Cole, Dana; Döpfer, Dörte; Fazil, Aamir; Fèvre, Eric; Gibb, Herman; Hald, Tine; Kirk, Martyn; Lake, Robin; Maertens de Noordhout, Charline; Mathers, Colin; McDonald, Scott

    2015-01-01

    textabstractBackground: The Foodborne Disease Burden Epidemiology Reference Group (FERG) was established in 2007 by the World Health Organization to estimate the global burden of foodborne diseases (FBDs). This paper describes the methodological framework developed by FERG's Computational Task Force to transform epidemiological information into FBD burden estimates. Methods and Findings: The global and regional burden of 31 FBDs was quantified, along with limited estimates for 5 other FBDs, u...

  20. Determinants of subjective and objective burden of informal caregiving of patients with psychotic disorders

    OpenAIRE

    Flyckt, Lena; Fatouros-Bergman, Helena; Koernig, Thomas

    2015-01-01

    Background: In a previous study, the objective burden of informal caregiving to patients with psychotic disorders amounted to 22 hours/week, and the subjective burden was huge with predominately anxiety and depression as main symptoms. In this study, determinants of the informal caregiving burden are analyzed to find foci for interventions to ease the size of burden. Methods: Patients with psychotic disorders (n = 107) and their informal caregivers (n = 118) were included. They were assessed ...

  1. Burden of informal care giving to patients with psychoses: A descriptive and methodological study

    OpenAIRE

    Flyckt, Lena; Löthman, Anna; Jörgensen, Leif; Rylander, Anders; Koernig, Thomas

    2013-01-01

    Background: There is a lack of studies of the size of burden associated with informal care giving in psychosis. Aims: To evaluate the objective and subjective burden of informal care giving to patients with psychoses, and to compare a diary and recall method for assessments of objective burden. Method: Patients and their informal caregivers were recruited from nine Swedish psychiatric outpatient centres. Subjective burden was assessed at inclusion using the CarerQoL and COPE index scales. The...

  2. Caregiver Burden in Patients Receiving Ranibizumab Therapy for Neovascular Age Related Macular Degeneration

    OpenAIRE

    Rishma Gohil; Roxanne Crosby-Nwaobi; Angus Forbes; Ben Burton; Phil Hykin; Sobha Sivaprasad

    2015-01-01

    Purpose To assess the caregiver burden and factors determining the burden in patients receiving ranibizumab therapy for neovascular AMD (nAMD). Methods This is a cross-sectional questionnaire survey of 250 matched patient caregiver dyads across three large ophthalmic treatment centres in United Kingdom. The primary outcome was the subjective caregiver burden measured using caregiver reaction assessment scale (CRA). Objective caregiver burden was determined by the caregiver tasks and level of ...

  3. Estimating the burden of disease from water, sanitation, and hygiene at a global level.

    OpenAIRE

    Prüss, Annette; Kay, David; Fewtrell, Lorna; Bartram, Jamie

    2002-01-01

    We estimated the disease burden from water, sanitation, and hygiene at the global level taking into account various disease outcomes, principally diarrheal diseases. The disability-adjusted life year (DALY) combines the burden from death and disability in a single index and permits the comparison of the burden from water, sanitation, and hygiene with the burden from other risk factors or diseases. We divided the world's population into typical exposure scenarios for 14 geographical regions. W...

  4. Burden and Depressive Symptoms Associated with Adult-Child Caregiving for Individuals with Heart Failure

    OpenAIRE

    Selma Bozkurt Zincir; Murat Sunbul; Serkan Zincir; Esra Aydin Sunbul; Mustafa Oguz; Fatma Feriha Cengiz; Erdal Durmus; Tarik Kivrak; Ibrahim Sari

    2014-01-01

    Background. The primary purpose of this study was to investigate adult-child caregiver burden in heart failure (HF) patients. Secondary purpose of the study was to identify the possible influencing factors for caregiver burden and depressive symptoms in a young adult-child caregiver group. Methods. A total of 138 adult-child caregivers and 138 patients with HF participated in this study. Caregivers’ burden, depressive symptoms, and anxiety levels were assessed by using Zarit Caregiver Burden ...

  5. Renewable energy burden sharing. REBUS. Effects of burden sharing and certificate trade on the renewable electricity market in Europe

    International Nuclear Information System (INIS)

    Creation of an internal market for renewable electricity will involve a political negotiation process, similar to previous European Union (EU) greenhouse gas negotiations. The Energy Ministers in the EU have agreed upon an overall target of 22% of electricity supply from Renewable Energy Sources (RES-E) and a distribution of targets over the individual Member States. The REBUS project provides insights in the effects of implementing targets for renewable electricity generation at EU Member State level and the impact of introducing burden sharing systems within the EU, such as a Tradable Green Certificate (TGC) system. Member States can participate in such burden sharing systems to reduce the costs of achieving RES-E targets. The project concentrated on the development of the REBUS model, which quantifies the impact of trade (in green certificates, quotas or targets), the specification of cost potential curves for renewable electricity options in each of the 15 EU Member States and the implementation of different rules to setting targets at individual Member State level. In addition, utilities and consumer organisations were interviewed on their requirements and expectations for an international burden sharing scheme. 49 refs

  6. Dementia with Lewy Bodies

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Dementia With Lewy Bodies Information Page Synonym(s): Lewy Body ... and Information Additional resources from MedlinePlus What is Dementia With Lewy Bodies? Dementia with Lewy bodies (DLB) ...

  7. The Burden Attributable to Mental and Substance Use Disorders as Risk Factors for Suicide: Findings from the Global Burden of Disease Study 2010

    OpenAIRE

    Ferrari, Alize J; Norman, Rosana E.; Freedman, Greg; Baxter, Amanda J.; Pirkis, Jane E; Harris, Meredith G.; Page, Andrew; Carnahan, Emily; Degenhardt, Louisa; Vos, Theo; Harvey A. Whiteford

    2014-01-01

    Background The Global Burden of Disease Study 2010 (GBD 2010) identified mental and substance use disorders as the 5th leading contributor of burden in 2010, measured by disability adjusted life years (DALYs). This estimate was incomplete as it excluded burden resulting from the increased risk of suicide captured elsewhere in GBD 2010's mutually exclusive list of diseases and injuries. Here, we estimate suicide DALYs attributable to mental and substance use disorders. Methods Relative-risk es...

  8. The Silent Language of an Artificial Body

    OpenAIRE

    Alina Maria Hrisca

    2012-01-01

    This article presents some alterations of body language, due to the interventions in/on thebody. Body language has been theorized a lot in the last decades, and one of the most importantauthors we will refer to is Paul Ekman and his micro-expressions theory. Ekman tried to give auniversaldecoderof involuntary face reactions, and this is important now more than ever, becausemicro-expression are more and more diminished, due to the latest chemical and technicalinterventions in/on the body (espe...

  9. 29 CFR 98.855 - Who has the burden of proof in a debarment action?

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Who has the burden of proof in a debarment action? 98.855 Section 98.855 Labor Office of the Secretary of Labor GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Debarment § 98.855 Who has the burden of proof in a debarment action? (a) We have the burden...

  10. 7 CFR 3017.855 - Who has the burden of proof in a debarment action?

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Who has the burden of proof in a debarment action? 3017.855 Section 3017.855 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE... (NONPROCUREMENT) Debarment § 3017.855 Who has the burden of proof in a debarment action? (a) We have the burden...

  11. 5 CFR 919.855 - Who has the burden of proof in a debarment action?

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Who has the burden of proof in a debarment action? 919.855 Section 919.855 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED... § 919.855 Who has the burden of proof in a debarment action? (a) We have the burden to prove that...

  12. 41 CFR 105-68.855 - Who has the burden of proof in a debarment action?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Who has the burden of proof in a debarment action? 105-68.855 Section 105-68.855 Public Contracts and Property Management...) Debarment § 105-68.855 Who has the burden of proof in a debarment action? (a) We have the burden to...

  13. 2 CFR 180.855 - Who has the burden of proof in a debarment action?

    Science.gov (United States)

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Who has the burden of proof in a debarment... SUSPENSION (NONPROCUREMENT) Debarment § 180.855 Who has the burden of proof in a debarment action? (a) The Federal agency has the burden to prove that a cause for debarment exists. (b) Once a cause for...

  14. The Latina Caregiver Burden Scale: Assessing the Factor Structure for Rapid Clinical Assessment

    Science.gov (United States)

    Land, Helen; Guada, Joseph

    2011-01-01

    The study of caregiver burden is important for those faced with chronic illnesses such as AIDS as caregivers are the first line of care provision, sustaining care recipients in the home. Because perception of burden may vary across caregiver cultural groups, accurate measurement of burden is crucial to offer culturally sensitive services for those…

  15. 26 CFR 301.7454-1 - Burden of proof in fraud and transferee cases.

    Science.gov (United States)

    2010-04-01

    ... the United States § 301.7454-1 Burden of proof in fraud and transferee cases. In any proceeding involving the issue whether the petitioner has been guilty of fraud with intent to evade tax, the burden of... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Burden of proof in fraud and transferee...

  16. Biological uptake analysis of organisms exposed to oil and chemically dispersed oil

    Energy Technology Data Exchange (ETDEWEB)

    Coelho, G. M.; Aurand, D. V. [Ecosystem Management and Associates Inc., Purcellville, VA (United States); Wright, D. A. [Maryland Univ., Chesapeake Biological Laboratory, Solomons, MD (United States)

    1999-07-01

    This paper presents the results of a preliminary evaluation of tissue samples that were archived from a full-scale biological study of water column, inter-tidal and benthic organisms exposed to weathered Arabian crude oil or to the same oil that was chemically dispersed with Corexit 9500. At various intervals during the experiment, fish, oysters and polychaetes were removed from the mesocosm tanks, and the tissue was analyzed for 40 individual PAHs using gas chromatography/mass spectrometry. It was found that it is possible to track PAH body burden in test animal tissues, even if the water column exposure period is very short, therefore inclusion of this type of analysis in future studies would be useful in evaluating effects of thresholds for various profiles, in both mesocosm and laboratory studies. 16 refs., 1 tab., 2 figs.

  17. Biological uptake analysis of organisms exposed to oil and chemically dispersed oil

    Energy Technology Data Exchange (ETDEWEB)

    Coelho, G. M.; Aurand, D. V. [Ecosystem Management and Associates Inc., Purcellville, VA (United States); Wright, D. A. [Maryland Univ., Chesapeake Biological Laboratory, Solomons, MD (United States)

    1999-08-01

    This paper presents the results of a preliminary evaluation of tissue samples that were archived from a full-scale biological study of water column, inter-tidal and benthic organisms exposed to weathered Arabian crude oil or to the same oil that was chemically dispersed with Corexit 9500. At various intervals during the experiment, fish, oysters and polychaetes were removed from the mesocosm tanks, and the tissue was analyzed for 40 individual PAHs using gas chromatography/mass spectrometry. It was found that it is possible to track PAH body burden in test animal tissues, even if the water column exposure period is very short, therefore inclusion of this type of analysis in future studies would be useful in evaluating effects of thresholds for various profiles, in both mesocosm and laboratory studies. 16 refs., 1 tab., 2 figs.

  18. Chemical Detection and Identification Techniques for Exobiology Flight Experiments

    Science.gov (United States)

    Kojiro, Daniel R.; Sheverev, Valery A.; Khromov, Nikolai A.

    2002-01-01

    Exobiology flight experiments require highly sensitive instrumentation for in situ analysis of the volatile chemical species that occur in the atmospheres and surfaces of various bodies within the solar system. The complex mixtures encountered place a heavy burden on the analytical Instrumentation to detect and identify all species present. The minimal resources available onboard for such missions mandate that the instruments provide maximum analytical capabilities with minimal requirements of volume, weight and consumables. Advances in technology may be achieved by increasing the amount of information acquired by a given technique with greater analytical capabilities and miniaturization of proven terrestrial technology. We describe here methods to develop analytical instruments for the detection and identification of a wide range of chemical species using Gas Chromatography. These efforts to expand the analytical capabilities of GC technology are focused on the development of detectors for the GC which provide sample identification independent of the GC retention time data. A novel new approach employs Penning Ionization Electron Spectroscopy (PIES).

  19. The Silent Language of an Artificial Body

    Directory of Open Access Journals (Sweden)

    Alina Maria Hrisca

    2012-07-01

    Full Text Available This article presents some alterations of body language, due to the interventions in/on thebody. Body language has been theorized a lot in the last decades, and one of the most importantauthors we will refer to is Paul Ekman and his micro-expressions theory. Ekman tried to give auniversaldecoderof involuntary face reactions, and this is important now more than ever, becausemicro-expression are more and more diminished, due to the latest chemical and technicalinterventions in/on the body (especially the face.Using observation and some new works in thefields of both philosophy and sociology, we will analyze the effects on body-language of thesealterations ofthe body.Minimizing a lot the micro-gestures and face-expressions, as well as stressingthe functional aspect of an artificial body, body-language has a lot to suffer. It gets reduced andpeople begin toreadbodies only through their presence, not by their expressions. Standardization anda very simplified body-language and non-verbal cues are also consequences of an artificial body.Allof this makes body-language hard to express and at the same time hard todecode. This paper stressesthe effects thatan artificial body has on body-language, and also the importance of choosing a rightpath in the future interventions in/over the body.

  20. Rota Viral Infection: A Significant Disease Burden to Libya.

    Directory of Open Access Journals (Sweden)

    Salem Alkoshi

    2014-10-01

    Full Text Available Rotavirus is a common infection causing 450,000 deaths annually primarily in children 5 years and below. Despite the high burden of disease, little is known about the epidemiology of rotavirus in Libya. The aim of this study was to estimate the rotavirus disease burden among Libyan children.A cross-sectional study was carried out prospectively among children 5 years old and below between August 2012 and April 2013. Stool samples of children with diarrhea attending the outpatient department or admitted to the pediatric wards, at three public hospitals within the northwestern region of Libya were tested for rotavirus. The seasonality, symptomology demographics and outcomes of rotavirus cases were determined and compared to other diarrhea illnesses. An estimated incidence rate per 100,000 children aged 5 years and below was determined.A total of 545 children with diarrhea were identified for participation. Results of rotavirus immunoassays determined 57% of cases were caused by rotavirus. Inpatients were more likely to be rotavirus positive than outpatients (58% vs. 53%, P<0.05, Most rotavirus positive cases (86% were found among children below 2 years of age. Rotaviral cases peaked in the winter, constituting 76% of diarrheal illness in February and very few rotavirus cases in the summer months. The incidence rate of rotavirus diarrhea was estimated at 640/100,000 children aged 5 years and below.Rotavirus infection poses a significant disease burden in Libya. Preventive measures such as proper hygiene should be emphasized. Introduction of vaccination against rotavirus into the national immunization program should be examined, as it would likely be a cost-effective investment.

  1. The geographical distribution and burden of trachoma in Africa.

    Directory of Open Access Journals (Sweden)

    Jennifer L Smith

    Full Text Available There remains a lack of epidemiological data on the geographical distribution of trachoma to support global mapping and scale up of interventions for the elimination of trachoma. The Global Atlas of Trachoma (GAT was launched in 2011 to address these needs and provide standardised, updated and accessible maps. This paper uses data included in the GAT to describe the geographical distribution and burden of trachoma in Africa.Data assembly used structured searches of published and unpublished literature to identify cross-sectional epidemiological data on the burden of trachoma since 1980. Survey data were abstracted into a standardised database and mapped using geographical information systems (GIS software. The characteristics of all surveys were summarized by country according to data source, time period, and survey methodology. Estimates of the current population at risk were calculated for each country and stratified by endemicity class.At the time of writing, 1342 records are included in the database representing surveys conducted between 1985 and 2012. These data were provided by direct contact with national control programmes and academic researchers (67%, peer-reviewed publications (17% and unpublished reports or theses (16%. Prevalence data on active trachoma are available in 29 of the 33 countries in Africa classified as endemic for trachoma, and 1095 (20.6% districts have representative data collected through population-based prevalence surveys. The highest prevalence of active trachoma and trichiasis remains in the Sahel area of West Africa and Savannah areas of East and Central Africa and an estimated 129.4 million people live in areas of Africa confirmed to be trachoma endemic.The Global Atlas of Trachoma provides the most contemporary and comprehensive summary of the burden of trachoma within Africa. The GAT highlights where future mapping is required and provides an important planning tool for scale-up and surveillance of trachoma

  2. Child's organism's burden in radiological examinations in stomatology

    International Nuclear Information System (INIS)

    Plastic holders were developed for fixing a photographic film in the patient's mouth in stomatological radiodiagnostic examinations of children. The holder serves to reduce the radiation burden of children. In addition, patient's gonads are protected with a shield, a lead apron or a cloth with a lead lining at least 1.5 mm thick. Also developed was a protective shield from a 2.0 mm lead sheet for intraoral examinations. The shield is to be installed in children stomatology offices. (H.S.)

  3. Radiation burden to hands of nuclear medicine personnel

    International Nuclear Information System (INIS)

    Radiation burden is discussed imposed to the hands of nuclear medicine personnel handling 99Mo-sup(99m)Tc generators, imported from the GDR and Great Britain. The results are compared with available foreign data. Routine monitoring of the hands of nuclear medicine personnel is recommended. Suitable types of dosimeters for such measurements are briefly discussed. The need is stressed of better care paid in periodic preventive examinations to the finger skin of those personnel, whose hands come in contact with radiopharmaceuticals during production or application

  4. The burden of inflammatory bowel disease in Europe

    DEFF Research Database (Denmark)

    Burisch, Johan; Jess, Tine; Martinato, Matteo; Lakatos, Peter L

    2013-01-01

    Inflammatory bowel diseases (IBD) are chronic disabling gastrointestinal disorders impacting every aspect of the affected individual's life and account for substantial costs to the health care system and society. New epidemiological data suggest that the incidence and prevalence of the diseases are...... increasing and medical therapy and disease management have changed significantly in the last decade. An estimated 2.5-3million people in Europe are affected by IBD, with a direct healthcare cost of 4.6-5.6bn Euros/year. Therefore, the aim of this review is to describe the burden of IBD in Europe by...

  5. Impetigo and scabies - Disease burden and modern treatment strategies.

    Science.gov (United States)

    Yeoh, Daniel K; Bowen, Asha C; Carapetis, Jonathan R

    2016-07-01

    Impetigo and scabies both present different challenges in resource-limited compared with industrialised settings. Severe complications of these skin infections are common in resource-limited settings, where the burden of disease is highest. The microbiology, risk factors for disease, diagnostic approaches and availability and suitability of therapies also vary according to setting. Taking this into account we aim to summarise recent data on the epidemiology of impetigo and scabies and describe the current evidence around approaches to individual and community based treatment. PMID:27180311

  6. [Prevalence of intimal pathogen burden in acute coronary syndromes].

    Science.gov (United States)

    Andrié, R; Braun, P; Heinrich, K-W; Lüderitz, B; Bauriedel, G

    2003-08-01

    Increasing evidence supports a link between serological evidence of prior exposure to infectious pathogens, pathogen burden, and the risk for future myocardial infarction and death in patients with coronary artery disease. Based on this concept, we evaluated the intimal presence of four pathogens in human coronary atheroma, clinically associated with acute coronary syndromes (ACS) and stable angina (SA), and the effect of pathogen burden on the expression of human heatshock protein 60 (hHSP60), a key protein in (auto-)immune pathogenesis of atherosclerosis. Coronary atherectomy specimens retrieved from 53 primary target lesions of patients with ACS (n=33) or SA (n=20) were assessed immunohistochemically for the presence of Chlamydia pneumoniae (C. pn.), Helicobacter pylori (H.p.), Cytomegalovirus (CMV) and Epstein-Barr Virus (EBV), and for the expression of hHSP60. Chlamydia pneumoniae was present in 74%, Helicobacter pylori in 32%, CMV in 13% and EBV in 42%. Exclusively C.pn. revealed a prevalence in ACS (91%) vs SA (45%; p<0.001). Immunohistochemical analysis revealed 6 lesions without, 21 lesions with 1, 17 lesions with 2, 6 lesions with 3 and 3 lesions with 4 infectious agents. As an important finding, the mean value in ACS lesions was significantly increased compared to those in SA (1.9 vs 1.1; p<0.01). ACS-subgroup analysis revealed the highest mean value in patients with pain at rest within the last two days (Braunwald class III). In addition, expression of hHSP60 was significantly higher in ACS (8.7%) compared to SA (1.3%; p<0.001). Pathogen burden correlated highly significant (p<0.01) with the expression of hHSP60 (r=0.44).Our data demonstrate the impact of intimal pathogen burden in plaque instability, and suggest the presence of (auto-)immunoreactions against upregulated hHSP60 as an important pathomechanism that may contribute to acute coronary syndromes. PMID:12955411

  7. The Burden of History in the Family Business Organization

    DEFF Research Database (Denmark)

    Hjorth, Daniel; Dawson, Alexandra

    2016-01-01

    In this article we focus on the study of history through the use of narratives, within the context of the prevalent form of organization worldwide: the family business. Specifically we consider the dilemma of the impossible gift of succession using Nietzsche’s discussion of the burden of history...... and paralleling the story of a family business succession with that of Shakespeare’s King Lear. This way, we seek to make a contribution to organizational studies by answering recent calls to engage more with history in studies of business organizations. By implication, the study also initiates an...... integration of family business studies into organization studies....

  8. Burden of disease--implications for future research.

    Science.gov (United States)

    Michaud, C M; Murray, C J; Bloom, B R

    2001-02-01

    One overall challenge for public health and medicine in the future is to allocate available resources effectively to reduce major causes of disease burden globally and to decrease health disparities between poor and affluent populations. The major risk factors for death and disability worldwide are malnutrition; poor water supply, sanitation, and personal and domestic hygiene; unsafe sexual behavior; tobacco use; alcohol use; occupational hazards; hypertension; physical inactivity; illicit drugs; and air pollution. The challenge for research in the 21st century is to maintain and improve life expectancy and the quality of life that was achieved for most of the world's population during the 20th century. PMID:11176854

  9. Addressing the burden of epilepsy: Many unmet needs.

    Science.gov (United States)

    Beghi, Ettore

    2016-05-01

    Epilepsy is a heterogeneous clinical condition characterized by recurrent unprovoked seizures, their causes and complications. The incidence, prevalence and mortality of epilepsy vary with age, place and time contributing to a variable extent to the burden of the disease. Diagnostic misclassification may have strong impact on personal and societal reflections of the disease in light of its clinical manifestations and the need for chronic treatment. Epilepsy accounts for a significant proportion of the world's disease burden ranking fourth after tension-type headache, migraine and Alzheimer disease. Among neurological diseases, it accounts for the highest disability-adjusted life year rates both in men and in women. Although epilepsy is self-remitting in up to 50% of cases, variable long-term prognostic patterns can be identified based on the response to the available treatments. Epilepsy carries an overall increased risk of premature mortality with variable estimates across countries. Premature mortality predominates in patients aged less than 50 years, with epilepsies due to structural/metabolic conditions, with generalized tonic-clonic seizures, and seizures not remitting under treatment. Among deaths directly attributable to epilepsy or seizures, included are sudden unexpected death in epilepsy (SUDEP), status epilepticus, accidents, drowning, unintentional injuries, and suicide. Somatic and psychiatric disorders prevail in patients with epilepsy than in people without epilepsy. Asthma, migraine and cerebral tumors tend to occur more frequently in younger adults while cardiovascular disorders, stroke, dementia and meningioma predominate in the elderly. As being a fairly common clinical condition affecting all ages and requiring long-term (sometimes lifelong) treatment, epilepsy carries high health care costs for the society. Direct costs peak in the first year after diagnosis and then vary according to the severity of the disease, the response to treatment, and

  10. Research on determination of bio-burden for radiation sterilization of health care products

    International Nuclear Information System (INIS)

    In order to provide data of bio-burden for dose setting in radiation sterilization, determination of bio-burden on 148 kinds of health care products from 52 manufacturers were carried out. The culture of microorganisms, different elution technology, and correction coefficient of the microbiological methods have been used for determination of bio-burden. Frequent distribution of bio-burden was established. 5 kinds of elution processes were checked. Actual data of bio-burden for dose setting in radiation sterilization was gotten. (authors)

  11. Chromosome aberration frequency in blood lymphocytes of animals with 239Pu lung burdens

    International Nuclear Information System (INIS)

    Other investigators have suggested a causal relationship between accidental 239Pu exposures in man and the presence of chromosome aberrations in blood lymphocytes. To assess this relationship experimimentally, 16 Rhesus monkeys and 171 Chinese hamsters were exposed by inhalation to 239PuO2 aerosols and an additional five hamsters were injected with 239Pu citrate and the frequency of aberrations in blood lymphocytes determined. After an initial rapid clearance phase, the 239Pu was retained in the monkey lung with a long effective half-life (greater than 500 days). At 30 days after inhalation, 99 percent of the sacrifice body burden was in the lungs of both species. The ranges of cumulative radiation dose to the hamster lungs 30 days after inhalation were calculated to be 80 to 170, 220 to 540, and 830 to 2120 rads for initial lung burden levels of 10 to 30, 30 to 70, and 180 to 260 nCi/g, respectively. By 120 days, these doses were calculated to be 40 to 350, 500 to 710, and 1440 to 2170 rads. Hamsters with the highest lung burdens had a median survival time of about 80 days. No deaths occurred in any of the other treated hamsters or monkeys by 250 days after 239Pu inhalation. Hamsters sacrificed at 30 days showed an increase in chromosome aberration frequency with increasing dose to lung. By 120 days after inhalation, the aberration frequency in the controls was 0.012. The frequency in animals with doses that produced significant life shortening (1440 to 2170 rads) had decreased to 0.018 and to 0.032 aberrations/cell in animals with lung doses of 500 to 710 rads. At 380 days after injection of 60 nCi 239Pu citrate/gm, hamster lymphocytes had an aberration frequency of 0.048 aberrations/cell. The level of chromosome damage in the 239PuO2 exposed monkeys at 30 and 90 days after inhalation was not different than observed in controls. (U.S.)

  12. Asbestos Lung Burden in Necroscopic Samples from the General Population of Milan, Italy.

    Science.gov (United States)

    Casali, Michelangelo; Carugno, Michele; Cattaneo, Andrea; Consonni, Dario; Mensi, Carolina; Genovese, Umberto; Cavallo, Domenico Maria; Somigliana, Anna; Pesatori, Angela Cecilia

    2015-08-01

    The present study analysed the asbestos lung burden in necroscopic samples from 55 subjects free from asbestos-related diseases, collected between 2009 and 2011 in Milan, Italy. Multiple lung samples were analysed by light microscopy (asbestos bodies, AB) and EDXA-scanning electron microscopy (asbestos fibres and other inorganic fibres). Asbestos fibres were detected in 35 (63.6%) subjects, with a higher frequency for amphiboles than for chrysotile. Commercial (CA) and non-commercial amphiboles (NCA) were found in roughly similar frequencies. The estimated median value was 0.11 million fibres per gram of dry lung tissue (mf g(-1)) for all asbestos, 0.09 mf g(-1) for amphiboles. In 44 (80.0%) subjects no chrysotile fibres were detected. A negative relationship between asbestos mass-weighted fibre count and year of birth (and a corresponding positive increase with age) was observed for amphiboles [-4.15%, 95% confidence interval (CI) = -5.89 to -2.37], talc (-2.12%, 95% CI = -3.94 to -0.28), and Ti-rich fibres (-3.10%, 95% CI = -5.54 to -0.60), but not for chrysotile (-2.84%, 95% CI = -7.69 to 2.27). Residential district, birthplace, and smoking habit did not affect the lung burden of asbestos or inorganic fibres. Females showed higher burden only for amphiboles (0.12 versus 0.03 mf g(-1) in males, P = 0.07) and talc fibres (0.14 versus 0 mf g(-1) in males, P = 0.03). Chrysotile fibres were shorter and thinner than amphibole fibres and NCA fibres were thicker than CA ones. The AB prevalence was 16.4% (nine subjects) with concentrations ranging from 10 to 110 AB g(-1) dry, well below the 1000 AB g(-1) threshold for establishing occupational exposure. No AB were found in subjects younger than 30 years. Our study demonstrated detectable levels of asbestos fibres in a sample taken from the general population. The significant increase with age confirmed that amphibole fibres are the most representative of cumulative exposure. PMID:25878166

  13. Whole-body monitoring: Goiania case, Brazil

    International Nuclear Information System (INIS)

    Due to the radiological Cs accident in Goiania, Goias in September 1987, it became necessary to evaluate internal contamination levels of: individuals from the general public that for any reason had direct or indirect involvement with the radioactive source (group 1); occupationally involved persons (group 2). For each of these groups, procedures of whole body monitoring were developped. In order to attend group 1 individuals, the IRD/CNEN installed a whole body unit in the INAMPS General Hospital of Goiania in 11.08.87, which was later transferred to 121, 57 street, Central Sector in Goiania in 2.06.88. In this unit 547 people were monitored, 356 from group 1 and 241 from group 2, until 04.13.88. In the IRD whole body counter installation, 194 individuals were counted, 185 from group 2 and 9 from group 1. The frequency of monitoring of each individual was stablished according to the Cs activity present in the body or to the job that will be done. Some body burden activity curves for Cs 137 as a function of the time elapsed from the first measurement, are presented. There people from group 1 were measured in both counters, the IRD and the Goiania ones. The values obtained in both installations are compatible with the body activity X time curve. (author)

  14. Monitoring of thorium incorporation by thoron in breath measurement: Methodology improvements and determination of burdens of workers

    International Nuclear Information System (INIS)

    Thorium body burdens were determined from thoron (220Rn) in breath measurements: decay products of expired 220Rn were collected electrostatically and their progeny were subsequently measured by alpha-spectrometry. The volume of the 38.5 litre collection chamber was optimised with respect to the breathing rate, the decay constant of thoron, the electric field geometry and strength, and the humidity of air. Calibration was achieved by means of a calibrated 228Th source. A minimum detectable activity of 45 mBq 224Ra freely emanating 220Rn at the mouth (Ra equivalent) was achieved. Five Thorotrast patients were measured and data ranged from 40 up to 150 Bq Ra equivalent, indicating an exhalation factor of about 4.0 ± 1.9% of the total 220Rn produced in the body. Data from 53 workers showed burdens up to 23 Bq (mean 5.5 Bq) of thorium. Urine bioassays of samples from the same workers yielded corresponding results. In vivo measurements revealed no result above the detection limit of 25 Bq 208Tl. (author)

  15. Caregiver burden in Danish family members of patients with severe brain injury

    DEFF Research Database (Denmark)

    Doser, Karoline; Norup, Anne

    more severe injuries, who spent more time on caregiving and reported more unmet needs. Overall, spouses spent significantly more time taking care of their family member than parents and reported higher levels of burden. CONCLUSIONS: The findings emphasized the continuing consequences of brain injury on......OBJECTIVE: To investigate caregiver burden and factors associated with caregiver burden among family members of patients with severe brain injury in the chronic phase. Additionally, the study aimed at investigating differences in burden between parents and spouses. METHODS: Forty-four Danish...... caregivers of patients with severe brain injury were contacted 3-6 years post-injury and asked to complete a measure of caregiver burden. RESULTS: Medium, high and low levels of burden were observed in 45%, 16% and 39% of family members, respectively. Higher burden was seen in caregivers of patients with...

  16. Thyroidal burdens of 129I from various dietary sources

    International Nuclear Information System (INIS)

    Thyroidal burdens of 129I were calculated for 1-, 4- and 14-yr-olds, and adults, using available dietary data. Milk and milk products contributed 63, 57, 54 and 33% of the total thyroidal 129I burden of the four respective age groups. As the contribution from dairy products decreased, that from meat increased from about 12% for 1-yr-olds to 35% for adults, while that from leafy vegetables remained relatively stable, from 17 to 21%. From ingested foods produced in air assumed to contain 1 pCi 129I per m3, daily dietary 129I intakes of 1.3, 1.2, 1.7 and 1.5 nCi were computed for the 1-, 4-, and 14-yr-old child and adult, respectively. For each nCi ingested daily, thyroidal dose rates for the respective age groups were calculated to be 4.9, 2.1, 1.7 and 2.6 rem/yr, with the altered dose rates reflecting age-related differences in thyroid gland size and iodine kinetics. (author)

  17. Air pollution burden of illness from traffic in Toronto

    International Nuclear Information System (INIS)

    This paper examined the health impacts of air pollution from traffic in Toronto. The paper provided a review of scientific studies on the health effects of vehicle pollution as well as a quantitative assessment of the economic costs and the burden of illness attributed to traffic pollution in Toronto. The report also assessed air pollution and traffic trends in the city, and outlined initiatives being conducted to reduce vehicle-related pollution. The study used the new air quality benefits tool (AQBAT) which determines the burden of illness and the economic impacts of traffic-related air pollution. Air modelling specialists were consulted in order to determine the contribution of traffic-related pollutants to overall pollution levels using data on traffic counts and vehicle emissions factors. The air model also considered dispersion, transport and and the transformation of compounds emitted from vehicles. Results of the study showed that traffic pollution caused approximately 440 premature deaths and 1700 hospitalizations per year. Children in the city experienced more than 1200 acute bronchitis episodes per year as a result of air pollution from traffic. Mortality-related costs associated with traffic pollution in Toronto were estimated at $2.2 billion. It was concluded that the city must pursue the implementation of sustainable transportation policies and programs which foster and enable the expansion and use of public transport. 47 refs., 8 tabs., 9 figs

  18. Air pollution burden of illness from traffic in Toronto

    Energy Technology Data Exchange (ETDEWEB)

    McKeown, D.; Campbell, M.; Bassil, K.; Morgan, C.; Lalani, M.; Macfarlane, R.; Bienefeld, M. [Toronto Public Health, ON (Canada)

    2007-11-15

    This paper examined the health impacts of air pollution from traffic in Toronto. The paper provided a review of scientific studies on the health effects of vehicle pollution as well as a quantitative assessment of the economic costs and the burden of illness attributed to traffic pollution in Toronto. The report also assessed air pollution and traffic trends in the city, and outlined initiatives being conducted to reduce vehicle-related pollution. The study used the new air quality benefits tool (AQBAT) which determines the burden of illness and the economic impacts of traffic-related air pollution. Air modelling specialists were consulted in order to determine the contribution of traffic-related pollutants to overall pollution levels using data on traffic counts and vehicle emissions factors. The air model also considered dispersion, transport and and the transformation of compounds emitted from vehicles. Results of the study showed that traffic pollution caused approximately 440 premature deaths and 1700 hospitalizations per year. Children in the city experienced more than 1200 acute bronchitis episodes per year as a result of air pollution from traffic. Mortality-related costs associated with traffic pollution in Toronto were estimated at $2.2 billion. It was concluded that the city must pursue the implementation of sustainable transportation policies and programs which foster and enable the expansion and use of public transport. 47 refs., 8 tabs., 9 figs.

  19. A comparability analysis of global burden sharing GHG reduction scenarios

    International Nuclear Information System (INIS)

    The distribution of the mitigation burden across countries is a key issue regarding the post-2012 global climate policies. This article explores the economic implications of alternative allocation rules, an assessment made in the run-up to the COP15 in Copenhagen (December 2009). We analyse the comparability of the allocations across countries based on four single indicators: GDP per capita, GHG emissions per GDP, GHG emission trends in the recent past, and population growth. The multi-sectoral computable general equilibrium model of the global economy, GEM-E3, is used for that purpose. Further, the article also compares a perfect carbon market without transaction costs with the case of a gradually developing carbon market, i.e. a carbon market with (gradually diminishing) transaction costs. - Highlights: ► Burden sharing of global mitigation efforts should consider equity and efficiency. ► The comparability of allocations across countries is based on four indicators. ► The four indicators are GDP/capita, GHG/GDP, population growth, and GHG trend. ► Any possible agreement on effort comparability needs a combination of indicators. ► We analyse the role played by the degree of flexibility in global carbon trading

  20. Effect of hydrogen on reduction of burden materials

    Energy Technology Data Exchange (ETDEWEB)

    Hooey, P.L. [Rautaruukki Oy, Raahe (Finland). Raahe Steel

    1996-12-31

    Efficient operation of iron blast furnaces requires that the iron bearing burden material have good reduction, softening and melting characteristics. These characteristics are determined by the physical operation of the blast furnace and the mineralogical composition of the agglomerate. Increasing oil injection rates will increase the hydrogen content of the reducing gas significantly. The aim of this work is to establish how different burden materials react to this change in gas environment, and develop sinters which have optimal properties. The testing of sinter and pellets is broken into two areas: development of the test methods; and determination of sinter and pellet characteristics. The test method requires development because recent testwork has shown that the reducibility of the sinter is now so high that the reduction under load test is no longer sensitive. A new control program and more realistic gas compositions are currently being tested. The softening and melting characteristics of sinters of varying composition, acid pellets and olivine pellets have been tested using the reduction under load test at Rautaruukki Oy Research Centre. The effect of hydrogen in the reducing gas on the different iron ore agglomerates has been evaluated SULA 2 Research Programme; 6 refs.

  1. Agricultural water consumption decreasing nutrient burden at Bohai Sea, China

    Science.gov (United States)

    Tong, Yindong; Wang, Xuejun; Zhen, Gengchong; Li, Ying; Zhang, Wei; He, Wei

    2016-02-01

    In this study, we discussed the impacts of human water consumption to the nutrient burden in a river estuary, and used Huanghe River as a case study. The agricultural water consumption from the Huanghe River has significantly decreased the natural water flows, and the amount of water consumption could be almost twice as high as the water entering into the estuary. According to our calculation, agricultural water usage decreased TN outflows by 6.5 × 104 Mg/year and TP outflows by 2.0 × 103 Mg/year. These account for 74% and 77% of the total output loads. It has been widely reported that the majority of the rivers in northern China were severely polluted by nutrients. Its implication on the budget of nutrient in the estuary ecosystem is not well characterized. Our study showed that the discharge of nutrients in the coast waters from polluted rivers was over concerned. Nutrients in the polluted rivers were transported back to the terrestrial systems when water was drawn for human water consumption. The magnitudes of changes in riverine nutrient discharges even exceed the water-sediment regulation trails in the Huanghe River. It has non-negligible impact on estimating the nutrient burden in costal water ecosystem.

  2. Quality assurance: a burden or an essential tool for management?

    International Nuclear Information System (INIS)

    The role of Quality Assurance in nuclear power plant management is discussed. Customer's satisfaction has always been considered by the supplier as a key factor to achieve his company's prosperity, provided that this satisfaction can be obtained in proper economical conditions. According to ISO standards, to satisfy the customer's need is in fact the definition of quality. Some twenty years ago nuclear safety introduced an additional notion: an evidence of satisfaction of customer's needs shall be provided - this is the Quality Assurance. Many companies on which this requirement was imposed experienced it and, in some cases continue to experience it, as an additional burden, due to the customer's lack of confidence. However, Code 50.C.QA clearly states in its introduction that Quality Assurance is an essential aspect of good management. It is very difficult to segregate the Quality Assurance Programme implementation efficiency from the company management efficiency. The arguments contained in the paper result in the following possible answer to the question in the title: a burden and an essential tool for management. (Z.S.)

  3. Burden of ischemic heart diseases in Iran, 1990-2010: Findings from the Global Burden of Disease study 2010

    Science.gov (United States)

    Maracy, Mohammad Reza; Isfahani, Motahareh Tabar; Kelishadi, Roya; Ghasemian, Anoosheh; Sharifi, Farshad; Shabani, Reihaneh; Djalalinia, Shirin; Majidi, Somayye; Ansari, Hossein; Asayesh, Hamid; Qorbani, Mostafa

    2015-01-01

    Background: Cardiovascular diseases are viewed worldwide as one of the main causes of death. This study aims to report the burden of ischemic heart diseases (IHDs) in Iran by using data of the global burden of disease (GBD) study, 1990-2010. Materials and Methods: The GBD study 2010 was a systematic effort to provide comprehensive data to calculate disability-adjusted life years (DALYs) for diseases and injuries in the world. Years of life lost (YLLs) due to premature mortality were computed on the basis of cause-of-death estimates, using Cause of Death Ensemble model (CODEm). Years lived with disability (YLDs) were assessed by the multiplication of prevalence, the disability weight for a sequel, and the duration of symptoms. A systematic review of published and unpublished data was performed to evaluate the distribution of diseases, and consequently prevalence estimates were calculated with a Bayesian meta-regression method (DisMod-MR). Data from population-based surveys were used for producing disability weights. Uncertainty from all inputs into the calculations of DALYs was disseminated by Monte Carlo simulation techniques. Results: The age-standardized IHDs DALY specified rate decreased 31.25% over 20 years from 1990 to 2010 [from 4720 (95% uncertainty interval (UI): 4,341-5,099) to 3,245 (95% UI: 2,810-3,529) person-years per 100,000]. The decrease were 38.14% among women and 26.87% among men. The age-standardized IHDs death specefied rate decreased by 21.17% [from 222) 95% UI: 207-243 (to 175 (95% UI:152-190) person-years per 100,000] in both the sexes. The age-standardized YLL and YLD rates decreased 32.05% and 4.28%, respectively, in the above period. Conclusion: Despite decreasing age-standardized IHD of mortality, YLL, YLD, and DALY rates from 1990 to 2010, population growth and aging increased the global burden of IHD. YLL has decreased more than IHD deaths and YLD since 1990 but IHD mortality remains the greatest contributor to disease burden. PMID

  4. Burden of ischemic heart diseases in Iran, 1990-2010: Findings from the Global Burden of Disease study 2010

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Maracy

    2015-01-01

    Full Text Available Background: Cardiovascular diseases are viewed worldwide as one of the main causes of death.This study aims to report the burden of ischemic heart diseases (IHDs in Iran by using data of the global burden of disease (GBD study, 1990-2010. Materials and Methods: The GBD study 2010 was a systematic effort to provide comprehensive data to calculate disability-adjusted life years (DALYs for diseases and injuries in the world. Years of life lost (YLLs due to premature mortality were computed on the basis of cause-of-death estimates, using Cause of Death Ensemble model (CODEm. Years lived with disability (YLDs were assessed by the multiplication of prevalence, the disability weight for a sequel, and the duration of symptoms. A systematic review of published and unpublished data was performed to evaluate the distribution of diseases, and consequently prevalence estimates were calculated with a Bayesian meta-regression method (DisMod-MR. Data from population-based surveys were used for producing disability weights. Uncertainty from all inputs into the calculations of DALYs was disseminated by Monte Carlo simulation techniques. Results: The age-standardized IHDs DALY specified rate decreased 31.25% over 20 years from 1990 to 2010 [from 4720 (95% uncertainty interval (UI: 4,341-5,099 to 3,245 (95% UI: 2,810-3,529 person-years per 100,000]. The decrease were 38.14% among women and 26.87% among men. The age-standardized IHDs death specefied rate decreased by 21.17% [from 222 95% UI: 207-243 (to 175 (95% UI:152-190 person-years per 100,000] in both the sexes. The age-standardized YLL and YLD rates decreased 32.05% and 4.28%, respectively, in the above period. Conclusion: Despite decreasing age-standardized IHD of mortality, YLL, YLD, and DALY rates from 1990 to 2010, population growth and aging increased the global burden of IHD. YLL has decreased more than IHD deaths and YLD since 1990 but IHD mortality remains the greatest contributor to disease burden.

  5. Utilização de método indireto para predição da composição química corporal de zebuínos Use of indirect method to predict chemical body composition in zebu cattle

    Directory of Open Access Journals (Sweden)

    André Mendes Jorge

    2000-12-01

    Full Text Available O objetivo deste trabalho foi desenvolver equações de predição da composição química corporal de zebuínos, por intermédio da análise química de amostra de seção representativa da carcaça. Utilizaram-se sessenta e três animais não-castrados das raças Gir, Guzerá, Mocho de Tabapuã e Nelore. Os conteúdos corporais de proteína, gordura e macroelementos minerais (cálcio, fósforo, potássio, magnésio e sódio foram determinados analisando-se amostras de seção da carcaça incluindo a 9ª, 10ª e 11ª costelas (seção HH e dos demais tecidos corporais. Os teores de proteína, gordura, energia e macroelementos minerais da secção HH, com exceção para o magnésio, mostraram-se altamente correlacionados com a composição química corporal. As equações de predição baseadas na composição química da secção HH mostraram-se confiáveis para estudos comparativos da composição corporal de zebuínos.The objective of this study was to develop equations to predict chemical body composition from zebu cattle, based on chemical composition from carcass representative section. Sixty-three young bulls from Gyr, Guzera, Nellore and Mocho de Tabapuã breeds were used. Body content of protein, fat and minerals were determined on samples from the carcass section that included the 9th, 10th and 11th rib joint (HH joint, and from the remaining body tissues. Protein, fat, energy and ash contents from the HH joint, except for magnesium, were closely related to protein, fat, energy and ash contents in the body. Prediction equations based on chemical composition from HH joint showed to be reliable for comparative studies of body composition of zebu cattle.

  6. Forecasting and Analyzing the Disease Burden of Aged Population in China, Based on the 2010 Global Burden of Disease Study

    Directory of Open Access Journals (Sweden)

    Chengzhen Bao

    2015-06-01

    Full Text Available Background: Forecasting the disease burden of the elderly will contribute to make a comprehensive assessment about physical and mental status of the elderly in China and provide a basis for reducing the negative consequences of aging society to a minimum. Methods: This study collected data from a public database online provided by Global Burden of Disease Study 2010. Grey model GM (1, 1 was used to forecast all-cause and disease-specific rates of disability adjusted life years (DALYs in 2015 and 2020. Results: After cross-sectional and longitudinal analysis, we found that non-communicable diseases (NCDs were still the greatest threats in the elderly, followed by injuries. As for 136 predicted causes, more than half of NCDs increased obviously with age, less than a quarter of communicable, material, neonatal, and nutritional disorders or injuries had uptrend. Conclusions: The findings display the health condition of the Chinese elderly in the future, which will provide critical information for scientific and sociological researches on preventing and reducing the risks of aging society.

  7. Dependency aspect of caregiver burden is uniquely related to cognitive impairment in Veterans

    Directory of Open Access Journals (Sweden)

    Jennifer M. Stinson, PhD

    2015-01-01

    Full Text Available The psychosocial toll of caring for an individual with dementia is an important, if understudied, concept. For practitioners and researchers alike, understanding the relation between patient characteristics and different facets of caregiver burden is important for guiding treatment and prevention efforts. The current study analyzed the dimensions of caregiver burden and the relation between caregiver burden and results of neuropsychological testing. Participants included 243 dyads of caregivers and Veterans referred for neuropsychological evaluation. Caregivers completed the Zarit Burden Interview (ZBI to assess caregiver burden. Patients completed a battery of neuropsychological tests measuring the domains of attention/processing speed, memory, language, and executive functioning. A principal components analysis of the ZBI revealed a three-factor structure: psychosocial burden, dependency burden, and guilt. Correlations with neuropsychological test performance by Veteran patients suggested that test performance in the memory, attention, processing speed, executive functioning, and emotional functioning domains were solely related to the caregiver dependency burden factor of the ZBI. Additional analyses suggested severity of dementia and number of tests in the impaired range further influenced reported caregiver burden. The current study is one of the few studies examining caregiver burden in relation to neuropsychological functioning in a mixed clinical sample and has important implications for clinical practice.

  8. A comparison of cancer burden and research spending reveals discrepancies in the distribution of research funding

    Directory of Open Access Journals (Sweden)

    Carter Ashley JR

    2012-07-01

    Full Text Available Abstract Background Ideally, the distribution of research funding for different types of cancer should be equitable with respect to the societal burden each type of cancer imposes. These burdens can be estimated in a variety of ways; “Years of Life Lost” (YLL measures the severity of death in regard to the age it occurs, "Disability-Adjusted Life-Years" (DALY estimates the effects of non-lethal disabilities incurred by disease and economic metrics focus on the losses to tax revenue, productivity or direct medical expenses. We compared research funding from the National Cancer Institute (NCI to a variety of burden metrics for the most common types of cancer to identify mismatches between spending and societal burden. Methods Research funding levels were obtained from the NCI website and information for societal health and economic burdens were collected from government databases and published reports. We calculated the funding levels per unit burden for a wide range of different cancers and burden metrics and compared these values to identify discrepancies. Results Our analysis reveals a considerable mismatch between funding levels and burden. Some cancers are funded at levels far higher than their relative burden suggests (breast cancer, prostate cancer, and leukemia while other cancers appear underfunded (bladder, esophageal, liver, oral, pancreatic, stomach, and uterine cancers. Conclusions These discrepancies indicate that an improved method of health care research funding allocation should be investigated to better match funding levels to societal burden.

  9. The burden of disease and injury in Iran 2003

    Directory of Open Access Journals (Sweden)

    Vaseghi Sanaz

    2009-06-01

    Full Text Available Abstract Background The objective of this study was to estimate the burden of disease and injury in Iran for the year 2003, using Disability-Adjusted Life Years (DALYs at the national level and for six selected provinces. Methods Methods developed by the World Health Organization for National Burden of Disease (NBD studies were applied to estimate disease and injury incidence for the calculation of Years of Life Lost due to premature mortality (YLL, Years Lived with Disability (YLD, and DALYs. The following adjustments of the NBD methodology were made in this study: a revised list with 213 disease and injury causes, development of new and more specific disease modeling templates for cancers and injuries, and adjustment for dependent comorbidity. We compared the results with World Health Organization (WHO estimates for Eastern Mediterranean Region, sub-region B in 2002. Results We estimated that in the year 2003, there were 21,572 DALYs due to all diseases and injuries per 100,000 Iranian people of all ages and both sexes. From this total number of DALYs, 62% were due to disability premature deaths (YLD and 38% were due to premature deaths (YLL; 58% were due to noncommunicable diseases, 28% – to injuries, and 14% – to communicable, maternal, perinatal, and nutritional conditions. Fifty-three percent of the total number of 14.349 million DALYs in Iran were in males, with 36.5% of the total due to intentional and unintentional injuries, 15% due to mental and behavioral disorders, and 10% due to circulatory system diseases; and 47% of DALYs were in females, with 18% of the total due to mental and behavioral disorders, 18% due to intentional and unintentional injuries, and 12% due to circulatory system diseases. The disease and injury causes leading to the highest number of DALYs in males were road traffic accidents (1.071 million, natural disasters (548 thousand, opioid use (510 thousand, and ischemic heart disease (434 thousand. The leading

  10. Lewy Body Disease

    Science.gov (United States)

    Lewy body disease is one of the most common causes of dementia in the elderly. Dementia is the loss of mental ... to affect normal activities and relationships. Lewy body disease happens when abnormal structures, called Lewy bodies, build ...

  11. Body Odor (For Girls)

    Science.gov (United States)

    ... Gynecology Medical Conditions Nutrition & Fitness Emotional Health Body Odor Posted under Health Guides . Updated 26 June 2015. + ... moisture, your body cools down. Where does body odor come from? When sweat mixes with the natural ...

  12. Body & Lifestyle Changes

    Science.gov (United States)

    ... Close X Home > Pregnancy > Body & lifestyle changes Body & lifestyle changes E-mail to a friend Please fill ... between pregnancies Nutrition, weight & fitness Prenatal care Body & lifestyle changes Is it safe? Labor & birth Postpartum care ...

  13. Inclusion Body Myositis

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Inclusion Body Myositis Information Page Table of Contents (click ... and Information Additional resources from MedlinePlus What is Inclusion Body Myositis? Inclusion body myositis (IBM) is one ...

  14. CHEMICAL TOXICITY OF URANIUM

    OpenAIRE

    2007-01-01

    Uranium, occurs naturally in the earth’s crust, is an alpha emitter radioactive element from the actinide group. For this reason, U-235 and U-238, are uranium isotopes with long half lives, have got radiological toxicity. But, for natural-isotopic-composition uranium (NatU), there is greater risk from chemical toxicity than radiological toxicity. When uranium is get into the body with anyway, also its chemical toxicity must be thought. [TAF Prev Med Bull 2007; 6(3.000): 215-220

  15. CHEMICAL TOXICITY OF URANIUM

    Directory of Open Access Journals (Sweden)

    Sermin Cam

    2007-06-01

    Full Text Available Uranium, occurs naturally in the earth’s crust, is an alpha emitter radioactive element from the actinide group. For this reason, U-235 and U-238, are uranium isotopes with long half lives, have got radiological toxicity. But, for natural-isotopic-composition uranium (NatU, there is greater risk from chemical toxicity than radiological toxicity. When uranium is get into the body with anyway, also its chemical toxicity must be thought. [TAF Prev Med Bull 2007; 6(3.000: 215-220

  16. Chemical use

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This is a summary of research and activities related to chemical use on Neal Smith National Wildlife Refuge between 1992 and 2009. The chemicals used on the Refuge...

  17. Foreign body orbital cyst

    DEFF Research Database (Denmark)

    Yazdanfard, Younes; Heegard, Steffen; Fledelius, Hans C.;

    2001-01-01

    Ophthalmology, penetrating orbital injury, orbital foreign body, ultrasound, computed tomography (CT), histology......Ophthalmology, penetrating orbital injury, orbital foreign body, ultrasound, computed tomography (CT), histology...

  18. Environmental burden from past uranium mining and milling activities

    International Nuclear Information System (INIS)

    Based on a government decree, the Czechoslovak Uranium Industry (CSUP) was required to adopt a uranium mining phasing-out programme in the late 1980s. Throughout the 1990s, uranium mining was abandoned step by step in the Czech Republic except for the Rozna deposit which is still in use. For 17 major mining sites, the environmental impacts caused by the mining activity and by the existing burden from past uranium exploration, mining and milling were assessed. Remedial actions are under way, including reclamation of the sites affected. The programme is funded from the state budget, and the implementation of the programme is the responsibility of the successor to the CSUP, i.e. DIAMO, a state-owned company seated at Straz pod Ralskem. (author)

  19. Preventing or reducing the Cs-137 burden in children

    International Nuclear Information System (INIS)

    Full text: The Helsinki Agreements impose intervention when a diagnosed disease can be cured or prevented. Since 1998 members of IPPNW Switzerland study health related problems due to the Chernobyl Fallout in the Ukraine and Belarus. The organisation furthermore finances diagnostic and radiometric activities, as measuring the Cs-137 burden in the organism. Also preventive measures are supported in cooperation with the french NGO 'Children of Chernobyl Belarus'. The Clinical Research Institute of Radiation Medicine and Endocrinology and the Gomel' State Med. Institute found correlations between chronic excess of Cs-137 and genetic, congenital, endocrine, immunological, cardiovascular, gastrointestinal, ophthalmologic anomalies and cancer. For etiological assessment the correlation between pathology and internal irradiation requires repeated measuring of Cs-137 burden. Anthropo-Gammametry measures of the mean Cs-137 load of the organism, which can be done in a few minutes. These values, however, cannot be used to directly calculate the dose to a given organ, as cesium concentrations may vary from 1 to 100 in the same child. Very low values of Cs-137 are found in skin and fatty tissue; in small children the highest concentrations are found in endocrine glands, pancreas, thymus and heart. Cs-137 is a gamma and beta emitting isotope. Whereas in the environment gamma emissions are important, once ingested beta emissions within millimeter distance are more damaging for cellular structures than gamma rays. Neurons of given brain structures localized in the left hemisphere (in right handed persons) also seem to be susceptible to ionizing radiations. There appear to be correlations with certain mental diseases and disorders, including schizophrenia and chronic fatigue syndrome. As regards to practical radiation protection, unfortunately families in rural areas rely on their own foodstuffs and milk and poor families frequently consume highly contaminated natural products. In

  20. Palm: Easing the Burden of Analytical Performance Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Tallent, Nathan R.; Hoisie, Adolfy

    2014-06-01

    Analytical (predictive) application performance models are critical for diagnosing performance-limiting resources, optimizing systems, and designing machines. Creating models, however, is difficult because they must be both accurate and concise. To ease the burden of performance modeling, we developed Palm, a modeling tool that combines top-down (human-provided) semantic insight with bottom-up static and dynamic analysis. To express insight, Palm defines a source code modeling annotation language. By coordinating models and source code, Palm's models are `first-class' and reproducible. Unlike prior work, Palm formally links models, functions, and measurements. As a result, Palm (a) uses functions to either abstract or express complexity (b) generates hierarchical models (representing an application's static and dynamic structure); and (c) automatically incorporates measurements to focus attention, represent constant behavior, and validate models. We discuss generating models for three different applications.

  1. Binge drinking: Burden of liver disease and beyond.

    Science.gov (United States)

    Llerena, Susana; Arias-Loste, María Teresa; Puente, Angela; Cabezas, Joaquín; Crespo, Javier; Fábrega, Emilio

    2015-11-28

    The consumption of alcoholic beverages is harmful to human health. In recent years, consumption patterns of alcoholic beverages have changed in our society, and binge drinking has generalized. It is considered to be a socio-sanitary problem with few known consequences in terms of individual and third-party social impacts (in the form of violence or traffic accidents) and its organic impact (affects the liver and other organs and systems, such as the nervous and cardiovascular systems) and represents an important financial burden due to its increasing economic impact. This review provides a global approach to binge drinking and emphasizes its epidemiological character, the effect of this type of consumption and the possible management of a problem with an increasing tendency in our society. PMID:26644814

  2. Burden of gastrointestinal cancer in Asia; an overview.

    Science.gov (United States)

    Pourhoseingholi, Mohamad Amin; Vahedi, Mohsen; Baghestani, Ahmad Reza

    2015-01-01

    The cancers in the digestive system including gastric cancer, colorectal cancer, liver cancer, esophageal cancer and pancreatic cancer are one of the most common cancers in Asia. The burden of GI cancer is increasing in Asia because of aging, growth of the population and the risk factors including smoking, obesity, changing lifestyle and high prevalence of H pylori, HBV and HCV. In most Asian countries, cancer control programs or early detection and treatment services are limited despite this increase. There are many people in the developing countries inside Asia who have no health insurance and many of them are too poor to go for screening tests, early detection or medical treatments. Therefore, it is important for the health organizations and governments in each country to recognize these groups and reduce the incidence and mortality of gastrointestinal cancers, using simple and economic screening test, vaccination and changing risk factors such as smoking, diet and lifestyle by education programs. PMID:25584172

  3. Crime and punishment: the economic burden of impunity

    Science.gov (United States)

    Gordon, M. B.; Iglesias, J. R.; Semeshenko, V.; Nadal, J. P.

    2009-03-01

    Crime is an economically relevant activity. It may represent a mechanism of wealth distribution but also a social and economic burden because of the interference with regular legal activities and the cost of the law enforcement system. Sometimes it may be less costly for the society to allow for some level of criminality. However, a drawback of such a policy is that it may lead to a high increase of criminal activity, that may become hard to reduce later on. Here we investigate the level of law enforcement required to keep crime within acceptable limits. A sharp phase transition is observed as a function of the probability of punishment. We also analyze other consequences of criminality as the growth of the economy, the inequality in the wealth distribution (the Gini coefficient) and other relevant quantities under different scenarios of criminal activity and probabilities of apprehension.

  4. Binge drinking: Burden of liver disease and beyond

    Institute of Scientific and Technical Information of China (English)

    Susana; Llerena; María; Teresa; Arias-Loste; Angela; Puente; Joaquín; Cabezas; Javier; Crespo; Emilio; Fábrega

    2015-01-01

    The consumption of alcoholic beverages is harmful to human health. In recent years, consumption patterns of alcoholic beverages have changed in our society, and binge drinking has generalized. It is considered to be a socio-sanitary problem with few known consequences in terms of individual and third-party social impacts(in the form of violence or traffic accidents) and its organic impact(affects the liver and other organs and systems, such as the nervous and cardiovascular systems) and represents an important financial burden due to its increasing economic impact. This review provides a global approach to binge drinking and emphasizes its epidemiological character, the effect of this type of consumption and the possible management of a problem with an increasing tendency in our society.

  5. The burden of serious fungal diseases in Russia.

    Science.gov (United States)

    Klimko, N; Kozlova, Y; Khostelidi, S; Shadrivova, O; Borzova, Y; Burygina, E; Vasilieva, N; Denning, D W

    2015-10-01

    The incidence and prevalence of fungal infections in Russia is unknown. We estimated the burden of fungal infections in Russia according to the methodology of the LIFE program (www.LIFE-worldwide.org). The total number of patients with serious and chronic mycoses in Russia in 2011 was three million. Most of these patients (2,607,494) had superficial fungal infections (recurrent vulvovaginal candidiasis, oral and oesophageal candidiasis with HIV infection and tinea capitis). Invasive and chronic fungal infections (invasive candidiasis, invasive and chronic aspergillosis, cryptococcal meningitis, mucormycosis and Pneumocystis pneumonia) affected 69,331 patients. The total number of adults with allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitisation was 406,082. PMID:26449508

  6. National Burden of Disease and Study in Iran

    Directory of Open Access Journals (Sweden)

    N Jafari

    2009-03-01

    Full Text Available "nBackground:  The objective of this study was to estimate the burden of disease and injury in Iran for the year 2003, using Disability-Adjusted Life Years (DALYs at the national level."nMethods: Methods developed by the World Health Organization for National Burden of Disease (NBD studies were ap­plied to estimate disease and injury incidence for the calculation of Years of Life Lost due to premature mortality (YLL, Years Lived with Disability (YLD, and DALYs. The following adjustments of the NBD methodology were made in this study: a revised list with 214 disease and injury causes, development of new and more specific disease modeling templates for cancers and injuries, and adjustment for dependent co morbidity."nResults: We estimated that in the year 2003, there were 21,572 DALYs due to all diseases and injuries per 100,000 Iranian people of all ages and both sexes, 62% were due to disability premature deaths (YLD and 38% were due to premature deaths (YLL; 58% were due to non communicable diseases, 28% - to injuries, and 14% - to communicable, maternal, peri­natal, and nutritional conditions. Fifty-three percent of the total number of 14.349 million DALYs in Iran were in males and 47% of DALYs were in females. The disease and injury causes leading to the highest number of DALYs in males were road traffic accidents, and in females were ischemic heart disease."nConclusions: The health and disease profile in Iran has made the transition from the dominance of communicable diseases to that of noncommunicable diseases and road traffic injuries. NBD results are to be used in health program planning, re­search, and resource allocation generation policies and practices.  

  7. Disease burden of chronic hepatitis C in Brazil

    Directory of Open Access Journals (Sweden)

    Paulo Roberto Abrão Ferreira

    2015-08-01

    Full Text Available Background: Hepatitis C virus infection is a major cause of cirrhosis; hepatocellular carcinoma; and liver transplantation. The aim of this study was to estimate hepatitis C virus disease progression and the burden of disease from a nationwide perspective.Methods: Using a model developed to forecast hepatitis C virus disease progression and the number of cases at each stage of liver disease; hepatitis C virus-infected population and associated disease progression in Brazil were quantified. The impact of two different strategies was compared: higher sustained virological response and treatment eligibility rates (1 or higher diagnosis and treatment rates associated with increased sustained virological response rates (2.Results: The number of infected individuals is estimated to decline by 35% by 2030 (1,255,000 individuals; while the number of cases of compensated (n= 325,900 and decompen- sated (n= 45,000 cirrhosis; hepatocellular carcinoma (n= 19,100; and liver-related deaths (n= 16,700 is supposed to peak between 2028 and 2032. In strategy 2; treated cases increased over tenfold in 2020 (118,800 treated as compared to 2013 (11,740 treated; with sustained virological response increased to 90% and treatment eligibility to 95%. Under this strategy; the number of infected individuals decreased by 90% between 2013 and 2030. Compared to the base case; liver-related deaths decreased by 70% by 2030; while hepatitis C virus-related liver cancer and decompensated cirrhosis decreased by 75 and 80%; respectively.Conclusions: While the incidence and prevalence of hepatitis C virus in Brazil are decreasing; cases of advanced liver disease continue to rise. Besides higher sustained virological response rates; new strategies focused on increasing the proportion of diagnosed patients and eligibility to treatment should be adopted in order to reduce the burden of hepatitis C virus infection in Brazil.

  8. Chemical sensor

    Science.gov (United States)

    Rauh, R. David (Inventor)

    1990-01-01

    A sensor for detecting a chemical substance includes an insertion element having a structure which enables insertion of the chemical substance with a resulting change in the bulk electrical characteristics of the insertion element under conditions sufficient to permit effective insertion; the change in the bulk electrical characteristics of the insertion element is detected as an indication of the presence of the chemical substance.

  9. Dependence and caregiver burden in Alzheimer's disease and mild cognitive impairment.

    LENUS (Irish Health Repository)

    Gallagher, Damien

    2011-03-01

    The dependence scale has been designed to be sensitive to the overall care needs of the patient and is considered distinct from standard measures of functional ability in this regard. Little is known regarding the relationship between patient dependence and caregiver burden. We recruited 100 patients with Alzheimer\\'s disease or mild cognitive impairment and their caregivers through a memory clinic. Patient function, dependence, hours of care, cognition, neuropsychiatric symptoms, and caregiver burden were assessed. Dependence was significantly correlated with caregiver burden. Functional decline and dependence were most predictive of caregiver burden in patients with mild impairment while behavioral symptoms were most predictive in patients with moderate to severe disease. The dependence scale demonstrated good utility as a predictor of caregiver burden. Interventions to reduce caregiver burden should address patient dependence, functional decline, and behavioral symptoms while successful management of the latter becomes more critical with disease progression.

  10. Burden of Injuries Avertable By a Basic Surgical Package in Low- and Middle-Income Regions: A Systematic Analysis From the Global Burden of Disease 2010 Study

    OpenAIRE

    Higashi, Hideki; Barendregt, Jan J.; Kassebaum, Nicholas J; Weiser, Thomas G; Bickler, Stephen W.; Vos, Theo

    2014-01-01

    Background Injuries accounted for 11 % of the global burden of disease in 2010. This study aimed to quantify the burden of injury in low- and middle-income countries (LMICs) that could be averted if basic surgical services were made available and accessible to the entire population. Methods We examined all causes of injury from the Global Burden of Disease 2010 Study. We split the disability-adjusted life years (DALYs) for these conditions between surgically “avertable” and “nonavertable” bur...

  11. Chemicals identified in feral and food animals: a data base. First annual report, October 1981. Volume I. Records 1-532

    International Nuclear Information System (INIS)

    This data file is a companion to Chemicals Identified in Human Biological Media, A Data Base, and follows basically the same format. The data base on human burden is in its third year of publication. This is the first annual report for the feral and food animal file. Data were obtained primarily from the open literature through manual searches (retrospective to 1979) of the journals listed in Appendix A. The data base now contains information on 60 different substances. Chemicals are listed by Chemical Abstracts Service (CAS) registry numbers and preferred names in Appendix B. For the user's convenience, cross-referenced chemical lists of CAS preferred and common names are provided in Appendix C. The animals, tissues, and body fluids found to be contaminated by these chemicals are listed in Appendix D. The data base is published annually in tabular format with indices and chemical listings that allow specific searching. A limited number of custom computer searches of the data base are available in special cases when the published format does not allow for retrieval of needed information

  12. Chemicals identified in feral and food animals: a data base. First annual report, October 1981. Volume I. Records 1-532

    Energy Technology Data Exchange (ETDEWEB)

    Cone, M.V.; Faust, R.A.; Baldauf, M.F. (comps.)

    1981-12-01

    This data file is a companion to Chemicals Identified in Human Biological Media, A Data Base, and follows basically the same format. The data base on human burden is in its third year of publication. This is the first annual report for the feral and food animal file. Data were obtained primarily from the open literature through manual searches (retrospective to 1979) of the journals listed in Appendix A. The data base now contains information on 60 different substances. Chemicals are listed by Chemical Abstracts Service (CAS) registry numbers and preferred names in Appendix B. For the user's convenience, cross-referenced chemical lists of CAS preferred and common names are provided in Appendix C. The animals, tissues, and body fluids found to be contaminated by these chemicals are listed in Appendix D. The data base is published annually in tabular format with indices and chemical listings that allow specific searching. A limited number of custom computer searches of the data base are available in special cases when the published format does not allow for retrieval of needed information.

  13. Approaches to Refining Estimates of Global Burden and Economics of Dengue

    OpenAIRE

    Shepard, Donald S.; Undurraga, Eduardo A.; Betancourt-Cravioto, Miguel; Guzmán, María G.; Halstead, Scott B; Harris, Eva; Mudin, Rose Nani; Murray, Kristy O.; Tapia-Conyer, Roberto; Gubler, Duane J.

    2014-01-01

    Dengue presents a formidable and growing global economic and disease burden, with around half the world's population estimated to be at risk of infection. There is wide variation and substantial uncertainty in current estimates of dengue disease burden and, consequently, on economic burden estimates. Dengue disease varies across time, geography and persons affected. Variations in the transmission of four different viruses and interactions among vector density and host's immune status, age, pr...

  14. Use of Expansion Factors to Estimate the Burden of Dengue in Southeast Asia: a Systematic Analysis

    OpenAIRE

    Donald S Shepard; Undurraga, Eduardo A.; Halasa, Yara A.

    2013-01-01

    BACKGROUND: Dengue poses a substantial economic and disease burden in Southeast Asia (SEA). Quantifying this burden is critical to set policy priorities and disease-control strategies. METHODS AND FINDINGS: We estimated the economic and disease burden of dengue in 12 countries in SEA: Bhutan, Brunei, Cambodia, East-Timor, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, and Viet Nam. We obtained reported cases from multiple sources--surveillance data, World Health Organiz...

  15. Taxation on Rural Sector: Tax Burden, Land Value and Property Right.

    OpenAIRE

    Piffano, Horacio Luis Pablo

    2010-01-01

    The paper analyzes tax burden on rural sector and its implication on property right of land. First, tax burden on land property and rural activities, and its incidence on land values are analyzed; next, the author tries to advance an economic foundation theory for evaluating a legal quantitative limit for the determination that judicial intervention had established, or may establish in the future, to define or differentiate tax burden as confiscatory and, therefore, violating property right.

  16. Study of level of stress and burden in the caregivers of children with mental retardation

    OpenAIRE

    Sethi, Sujata; Bhargava, Subhash C.; Dhiman, Vishal

    2013-01-01

    Abstract. Mental retardation is one of the most prevalent developmental disabilities. Family is the main source of support for the persons with disabilities in any society. Families experience a great deal of physical and emotional burden whilst caring for such relatives. This study tries to look into the issues such as the impact of severity of mental retardation on the level of stress and burden perceived by the caregivers. Key words: Mental retardation, caregivers, stress, burden

  17. Burden of Health Care Costs: Businesses, Households, and Governments, 1987-2000

    OpenAIRE

    Cowan, Cathy A.; McDonnell, Patricia A.; Levit, Katharine R.; Zezza, Mark A.

    2002-01-01

    In this article, we estimate expenditures by businesses, households, and governments in providing financing for health care for 1987-2000 and track measures of burden that these costs impose. Although burden measures for businesses and the Federal Government have stabilized or improved since 1993, measures of burden for State and local governments are deteriorating slightly—a situation that is likely to worsen in the near future. As health care spending accelerates and an economywide recessio...

  18. Perceived Parent Financial Burden and Asthma Outcomes in Low-Income, Urban Children

    OpenAIRE

    Patel, Minal R.; Brown, Randall W; Clark, Noreen M.

    2012-01-01

    The purpose of this study was to describe the demographic characteristics of low-income parents who perceive financial burden in managing their child’s asthma and related associations with their children’s asthma outcomes and clinical characteristics. We hypothesized that (1) identifiable differences between parents who do and do not report burden; (2) regardless of access to care, asthma outcomes would be worse for children whose parents perceive financial burden in obtaining care for their ...

  19. The financial burden of cancer: Estimates from patients undergoing cancer care in a tertiary care hospital

    OpenAIRE

    Zaidi Adnan A; Ansari Tayyaba Z; Khan Aziz

    2012-01-01

    Abstract Introduction The emotional burden associated with the diagnosis of cancer is sometimes overshadowed by financial burden sustained by patient and the family. This is especially relevant for a developing country as there is limited state support for cancer treatment. We conducted this study to estimate the cost of cancer care for two major types of cancer and to assess the perception of patients and families regarding the burden of the cost for undergoing cancer treatment at a private ...

  20. COMPARISON OF THE EXTENT AND PATTERN OF FAMILY BURDEN IN AFFECTIVE DISORDERS AND SCHIZOPHRENIA

    OpenAIRE

    Chakrabarti, Subho; Raj, Lok; Kulhara, Parmanand; Avasthi, Ajit; Verma, Santhosh K.

    1995-01-01

    This study sought to compare the extent and pattern of burden experienced by relatives of two different patient groups, one with affective disorders and the other with schizophrenia. Cross-sectional assessment of family burden using the Pai and Kapur's Interview Schedule was done in 78 patients with either bipolar disorder or recurrent major depression and 60 patients with schizophrenia diagnosed according to DSM-III. The inter-rater reliability of the interview schedule for burden was also u...