Sample records for characterize mechanisms controlling

  1. Mechanical characterization of calcium pectinate hydrogel for controlled drug delivery

    Directory of Open Access Journals (Sweden)

    Chung Jin Thau


    Full Text Available Calcium pectinate beads, a paniculate hydrogel system, is an attractive drug carrier for oral delivery. In this study, a poorly water-soluble model drug indomethacin was incorporated into calcium pectinate beads made of different pectin concentrations, which were produced by an extrusion method. The effect of pectin concentration on bead size, circularity, swelling behavior, and mechanical properties, as well as in vitro drug release profile was investigated. The mechanical properties of calcium pectinate beads were determined by a micromanipulation technique. The drug release profile was measured using a standard British Pharmacopoeia method. It was found that the beads made of higher pectin concentration in general had a less permeable matrix structure and greater mechanical rigidity, although they swelled more after hydration. However, such an effect was not significant when the pectin concentration was increased to above 8%. Micromanipulation measurements showed that there was significant relaxation of the force being imposed on single hydrated beads when they were held, but this phenomenon did not occur on dry beads, which means that the force relaxation was dominated by liquid loss from the beads. The rate of the force relaxation was determined, and has been related to the release rate of the model drug entrapped in the calcium pectinate beads.

  2. Characterization of molecular mechanisms controlling fabAB transcription in Pseudomonas aeruginosa.

    Directory of Open Access Journals (Sweden)

    Herbert P Schweizer

    Full Text Available BACKGROUND: The FabAB pathway is one of the unsaturated fatty acid (UFA synthesis pathways for Pseudomonas aeruginosa. It was previously noted that this operon was upregulated in biofilms and repressed by exogenous UFAs. Deletion of a 30 nt fabA upstream sequence, which is conserved in P. aeruginosa, P. putida, and P. syringae, led to a significant decrease in fabA transcription, suggesting positive regulation by an unknown positive regulatory mechanism. METHODS/PRINCIPAL FINDINGS: Here, genetic and biochemical approaches were employed to identify a potential fabAB activator. Deletion of candidate genes such as PA1611 or PA1627 was performed to determine if any of these gene products act as a fabAB activator. However, none of these genes were involved in the regulation of fabAB transcription. Use of mariner-based random mutagenesis to screen for fabA activator(s showed that several genes encoding unknown functions, rpoN and DesA may be involved in fabA regulation, but probably via indirect mechanisms. Biochemical attempts performed did fail to isolate an activator of fabAB operon. CONCLUSION/SIGNIFICANCE: The data suggest that fabA expression might not be regulated by protein-binding, but by a distinct mechanism such as a regulatory RNA-based mechanism.

  3. Characterization, Geometry, Temporal Evolution and Controlling Mechanisms of the Jettan Rock-Slide, Northern Norway

    DEFF Research Database (Denmark)

    Blikra, Lars Harald; Christiansen, Hanne Hvidtfeldt; Kristensen, Lene


    part of the rockslide sectors has discontinuous permafrost, while sporadic permafrost is documented to exist in the open fractures in the lower parts. The seasonal changes is thought to be controlled by changing shear strength of the brecciated sliding planes due to either raising ice temperatures...... within the detachment zones and/or variations in water infiltration from local ice bodies to the unsaturated sliding zones....

  4. Evaluation and characterization of mechanisms controlling fate and effects of Army smokes

    Energy Technology Data Exchange (ETDEWEB)

    Cataldo, D.A.; Ligotke, M.W.; Bolton, H. Jr.; Fellows, R.J.; Van Voris, P.; McKinley, J.P.; Mi, Shu-mei W.; McFadden, K.M.


    The primary objective of this study was to characterize the fate and response of soil and biotic components of the terrestrial environment to aerosols, deposited brass, and brass in combination with fog oil. Important physical, chemical, and biotic aspects were investigated using an environmental wind tunnel. Air/surface deposition rates were determined for foliar and soil surfaces, both in the absence and presence of fog oil. Deposition velocities for foliage ranged from 0.1 to 1.0 cm/s at wind speeds of 2 to 10 mph, respectively. Foliar contact toxicity was assessed using five different types of terrestrial vegetation representative of Army training sites and surrounding environments. No significant foliar contact toxicity was observed for brass. The weathering and chemistry of brass aerosols deposited and amended to soils was assessed, along with the impacts of acid precipitation and moisture regimes on weathering rates. Rates of brass weathering and the fate of solubilized Cu and Zn are discussed. The influence of soil weathering processes and brass solubilization on seed germination indicated no detectable effects of brass. However, moderate toxicity effects were noted after seed germination indicated no detectable effects of brass. However, moderate toxicity effects were noted after 160 days of soil incubation. The effects were proportional to soil-loading levels. Influence of soil weathering processes and contaminant solubilization on soil microbiological activities indicated that soil dehydrogenase activity was more susceptible to impacts than was phosphatase activity or microbial biomass. Nitrifying bacteria and heterotrophic bacteria were not significantly affected by brass. Invertebrates (earthworms) associated with soil contaminated with brass were only slightly impacted, and only at loading rates >445 {mu}g/cm{sup 2}.

  5. Nonholonomic mechanics and control

    CERN Document Server

    Murray, RM


    This book explores some of the connections between control theory and geometric mechanics; that is, control theory is linked with a geometric view of classical mechanics in both its Lagrangian and Hamiltonian formulations and in particular with the theory of mechanical systems subject to motion constraints. The synthesis of the topic is appropriate as there is a particularly rich connection between mechanics and nonlinear control theory. The book provides a unified treatment of nonlinear control theory and constrained mechanical systems and illustrates the elegant mathematics behind many simple, interesting, and useful mechanical examples. It is intended for graduate students who wish to learn this subject and researchers in the area who want to enhance their techniques. The book contains sections focusing on physical examples and elementary terms, as well as theoretical sections that use sophisticated analysis and geometry. The first four chapters offer preliminaries and background information, while the...

  6. Mechanical Characterization of Mancos Shale (United States)

    Broome, S.; Ingraham, M. D.; Dewers, T. A.


    A series of tests on Mancos shale have been undertaken to determine the failure surface and to characterize anisotropy. This work supports additional studies which are being performed on the same block of shale; fracture toughness, permeability, and chemical analysis. Mechanical tests are being conducted after specimens were conditioned for at least two weeks at 70% constant relative humidity conditions. Specimens are tested under drained conditions, with the constant relative humidity condition maintained on the downstream side of the specimen. The upstream is sealed. Anisotropy is determined through testing specimens that have been cored parallel and perpendicular to the bedding plane. Preliminary results show that when loaded parallel to bedding the shale is roughly 50% weaker. Test are run under constant mean stress conditions when possible (excepting indirect tension, unconfined compression, and hydrostatic). Tests are run in hydrostatic compaction to the desired mean stress, then differential stress is applied axially in displacement control to failure. The constant mean stress condition is maintained by decreasing the confining pressure by half of the increase in the axial stress. Results will be compared to typical failure criteria to investigate the effectiveness of capturing the behavior of the shale with traditional failure theory. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. SAND2015-6107 A.

  7. Mechanical and thermal property characterization of poly-L-lactide (PLLA) scaffold developed using pressure-controllable green foaming technology

    Energy Technology Data Exchange (ETDEWEB)

    Sheng, Shen-Jun [Center of Analysis and Testing, Nanjing Normal University, Nanjing 210023 (China); School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023 (China); Hu, Xiao [Department of Physics and Astronomy, Rowan University, Glassboro, NJ 08028 (United States); Department of Biomedical and Translational Sciences, Rowan University, Glassboro, NJ 08028 (United States); Wang, Fang, E-mail: [Center of Analysis and Testing, Nanjing Normal University, Nanjing 210023 (China); Department of Physics and Astronomy, Rowan University, Glassboro, NJ 08028 (United States); Ma, Qing-Yu [Key Laboratory of Optoelectronics of Jiangsu Province, School of Physics and Technology, Nanjing Normal University, Nanjing 210023 (China); Gu, Min-Fen [Center of Analysis and Testing, Nanjing Normal University, Nanjing 210023 (China)


    Poly-L-lactide (PLLA) is one of the most promising biological materials used for tissue engineering scaffolds (TES) because of their excellent biodegradability and tenability. Here, microcellular PLLA foams were fabricated by pressure-controllable green foaming technology. Scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), differential scanning calorimetry (DSC), wide angle X-ray diffraction measurement (WAXRD), thermogravimetric (TG) analysis, reflection-Fourier transform infrared (FTIR) analysis, enzymatic degradation study and MTT assay were used to analyze the scaffolds' morphologies, structures and crystallinities, mechanical and biodegradation properties, as well as their cytotoxicity. The results showed that PLLA foams with pore sizes from 8 to 103 μm diameters were produced when the saturation pressure decreased from 7.0 to 4.0 MPa. Through a combination of StepScan DSC (SSDSC) and WAXRD approaches, it was observed in PLLA foams that the crystallinity, highly-oriented metastable state and rigid amorphous phase increased with the increasing foaming pressure. It was also found that both the glass transition temperature and apparent enthalpy of PLLA significantly increased after the foaming process, which suggested that the changes of microcellular structure could provide PLLA scaffolds better thermal stability and elasticity. Moreover, MTT assessments suggested that the smaller pore size should benefit cell attachment and growth in the scaffold. The results of current work will give us better understanding of the mechanisms involved in structure and property changes of PLLA at the molecular level, which enables more possibilities for the design of PLLA scaffold to satisfy various requirements in biomedical and green chemical applications. - Highlights: • Pressure-controllable green foaming technology is used. • The crystallinity and rigid amorphous fraction is calculated by using DSC and XRD. • We examine the changes of

  8. Mechanical and thermal property characterization of poly-l-lactide (PLLA) scaffold developed using pressure-controllable green foaming technology. (United States)

    Sheng, Shen-Jun; Hu, Xiao; Wang, Fang; Ma, Qing-Yu; Gu, Min-Fen


    Poly-l-lactide (PLLA) is one of the most promising biological materials used for tissue engineering scaffolds (TES) because of their excellent biodegradability and tenability. Here, microcellular PLLA foams were fabricated by pressure-controllable green foaming technology. Scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), differential scanning calorimetry (DSC), wide angle X-ray diffraction measurement (WAXRD), thermogravimetric (TG) analysis, reflection-Fourier transform infrared (FTIR) analysis, enzymatic degradation study and MTT assay were used to analyze the scaffolds' morphologies, structures and crystallinities, mechanical and biodegradation properties, as well as their cytotoxicity. The results showed that PLLA foams with pore sizes from 8 to 103μm diameters were produced when the saturation pressure decreased from 7.0 to 4.0MPa. Through a combination of StepScan DSC (SSDSC) and WAXRD approaches, it was observed in PLLA foams that the crystallinity, highly-oriented metastable state and rigid amorphous phase increased with the increasing foaming pressure. It was also found that both the glass transition temperature and apparent enthalpy of PLLA significantly increased after the foaming process, which suggested that the changes of microcellular structure could provide PLLA scaffolds better thermal stability and elasticity. Moreover, MTT assessments suggested that the smaller pore size should benefit cell attachment and growth in the scaffold. The results of current work will give us better understanding of the mechanisms involved in structure and property changes of PLLA at the molecular level, which enables more possibilities for the design of PLLA scaffold to satisfy various requirements in biomedical and green chemical applications.

  9. Patterning mechanisms controlling digit development

    Institute of Scientific and Technical Information of China (English)


    Vertebrate digits are essential structures for movement,feeding and communication.Specialized regions of the developing limb bud including the zone of polarizing activity(ZPA),the apical ectodermal ridge(AER),and the non-ridge ectoderm regulate the patterning of digits.Although a series of signaling molecules have been characterized as patterning signals from the organizing centers,the delicate cellular and molecular mechanisms that interpret how these patterning signals control the detailed digit anatomy remain unclear.Recent studies from model organisms and human hand malformations provide new insights into the mechanisms regulating this process.Here,we review the current understanding of the genetic networks governing digit morphogenesis.

  10. Controlled mechanized trepan. (United States)

    Kam, J; Goldratt, E M; Barishak, Y R; Stein, R


    A mechanized trepan is described whose cutting action is halted automatically when the trepan's cutting edge reaches the last 0.03 mm. tissue layer of the cornea. The automatic half of both the motor which advances the trepan as well as the second motor which rotates the trepan is triggered by the sudden change in electrical resistance between the trepan and the patient's internal body fluid, at the final stage of penetration. This automatic feature eliminates the danger of inadvertant damage to the inner structures of the eye.

  11. Optimal Control of Mechanical Systems


    Vadim Azhmyakov


    In the present work, we consider a class of nonlinear optimal control problems, which can be called “optimal control problems in mechanics.” We deal with control systems whose dynamics can be described by a system of Euler-Lagrange or Hamilton equations. Using the variational structure of the solution of the corresponding boundary-value problems, we reduce the initial optimal control problem to an auxiliary problem of multiobjective programming. This technique makes it possible to apply some ...

  12. Photo darkening characterization and mechanisms

    DEFF Research Database (Denmark)

    Mattsson, Kent Erik


    and the mechanism both of color center formation and the physics of the color center is described. Experimentally the induced PD is found to be either partially or fully reversed through temperature annealing or exposure to UV and/or visible light. Even bleach by the 915 nm pump power gives this possibility...

  13. Optimal Control of Mechanical Systems

    Directory of Open Access Journals (Sweden)

    Vadim Azhmyakov


    Full Text Available In the present work, we consider a class of nonlinear optimal control problems, which can be called “optimal control problems in mechanics.” We deal with control systems whose dynamics can be described by a system of Euler-Lagrange or Hamilton equations. Using the variational structure of the solution of the corresponding boundary-value problems, we reduce the initial optimal control problem to an auxiliary problem of multiobjective programming. This technique makes it possible to apply some consistent numerical approximations of a multiobjective optimization problem to the initial optimal control problem. For solving the auxiliary problem, we propose an implementable numerical algorithm.

  14. Muscle mechanics and neuromuscular control

    NARCIS (Netherlands)

    Hof, AL


    The purpose of this paper is to demonstrate that the properties of the mechanical system, especially muscle elasticity and limb mass, to a large degree determine force output and movement. This makes the control demands of the central nervous system simpler and more robust. In human triceps surae, a

  15. Cellular mechanisms that control mistranslation

    DEFF Research Database (Denmark)

    Reynolds, Noah M; Lazazzera, Beth A; Ibba, Michael


    Mistranslation broadly encompasses the introduction of errors during any step of protein synthesis, leading to the incorporation of an amino acid that is different from the one encoded by the gene. Recent research has vastly enhanced our understanding of the mechanisms that control mistranslation...

  16. Chaos Control in Mechanical Systems

    Directory of Open Access Journals (Sweden)

    Marcelo A. Savi


    Full Text Available Chaos has an intrinsically richness related to its structure and, because of that, there are benefits for a natural system of adopting chaotic regimes with their wide range of potential behaviors. Under this condition, the system may quickly react to some new situation, changing conditions and their response. Therefore, chaos and many regulatory mechanisms control the dynamics of living systems, conferring a great flexibility to the system. Inspired by nature, the idea that chaotic behavior may be controlled by small perturbations of some physical parameter is making this kind of behavior to be desirable in different applications. Mechanical systems constitute a class of system where it is possible to exploit these ideas. Chaos control usually involves two steps. In the first, unstable periodic orbits (UPOs that are embedded in the chaotic set are identified. After that, a control technique is employed in order to stabilize a desirable orbit. This contribution employs the close-return method to identify UPOs and a semi-continuous control method, which is built up on the OGY method, to stabilize some desirable UPO. As an application to a mechanical system, a nonlinear pendulum is considered and, based on parameters obtained from an experimental setup, analyses are carried out. Signals are generated by numerical integration of the mathematical model and two different situations are treated. Firstly, it is assumed that all state variables are available. After that, the analysis is done from scalar time series and therefore, it is important to evaluate the effect of state space reconstruction. Delay coordinates method and extended state observers are employed with this aim. Results show situations where these techniques may be used to control chaos in mechanical systems.

  17. Dynamics and control of a class of underactuated mechanical systems

    NARCIS (Netherlands)

    Reyhanoglu, Mahmut; Schaft, van der Arjan; McClamroch, N. Harris; Kolmanovsky, Ilya


    This paper presents a theoretical framework for the dynamics and control of underactuated mechanical systems, defined as systems with fewer inputs than degrees of freedom. Control system formulation of underactuated mechanical systems is addressed and a class of underactuated systems characterized b

  18. Dynamics and Control of a Class of Underactuated Mechanical Systems

    NARCIS (Netherlands)

    Reyhanoglu, Mahmut; Schaft, Arjan van der; McClamroch, N. Harris; Kolmanovsky, Ilya


    This paper presents a theoretical framework for the dynamics and control of underactuated mechanical systems, defined as systems with fewer inputs than degrees of freedom. Control system formulation of underactuated mechanical systems is addressed and a class of underactuated systems characterized b

  19. Mechanical characterization of microwave sintered zinc oxide

    Indian Academy of Sciences (India)

    A K Mukhopadhyay; M Ray Chaudhuri; A Seal; S K Dalui; M Banerjee; K K Phani


    The mechanical characterization of microwave sintered zinc oxide disks is reported. The microwave sintering was done with a specially designed applicator placed in a domestic microwave oven operating at a frequency of 2.45 GHz to a maximum power output of 800 Watt. These samples with a wide variation of density and hence, of open pore volume percentage, were characterized in terms of its elastic modulus determination by ultrasonic time of flight measurement using a 15 MHz transducer. In addition, the load dependence of the microhardness was examined for the range of loads 0.1–20 N. Finally, the fracture toughness data (IC) was obtained using the indentation technique.

  20. Autoregulatory mechanisms controlling the microprocessor. (United States)

    Triboulet, Robinson; Gregory, Richard I


    The Microprocessor, comprising the ribonuclease Drosha and its essential cofactor, the double-stranded RNA-binding protein, DGCR8, is essential for the first step of the miRNA biogenesis pathway. It specifically cleaves double-stranded RNA within stem-loop structures of primary miRNA transcripts (pri-miRNAs) to generate precursor (pre-miRNA) intermediates. Pre-miRNAs are subsequently processed by Dicer to their mature ∼22 nt form. Thus, Microprocessor is essential for miRNA maturation, and pri-miRNA cleavage by this complex defines one end of the mature miRNA. Moreover, it is emerging that dysregulation of the Microprocessor is associated with various human diseases. It is therefore important to understand the mechanisms by which the expression of the subunits of the Microprocessor is regulated. Recent findings have uncovered a post-transcriptional mechanism that maintains the integrity of the Microprocessor. These studies revealed that the Microprocessor is involved in the processing of the messenger RNA (mRNA) that encodes DGCR8. This regulatory feedback loop, along with the reported role played by DGCR8 in the stabilization of Drosha protein, is part of a newly identified regulatory mechanism controlling Microprocessor activity.

  1. Control mechanisms for ecological-economic systems

    CERN Document Server

    Burkov, Vladimir N; Shchepkin, Alexander V


    This monograph presents and analyzes the optimization, game-theoretic and simulation models of control mechanisms for ecological-economic systems. It is devoted to integrated assessment mechanisms for total risks and losses, penalty mechanisms, risk payment mechanisms, financing and costs compensation mechanisms for risk level reduction, sales mechanisms for risk level quotas, audit mechanisms, mechanisms for expected losses reduction, economic motivation mechanisms, optimization mechanisms for regional environmental (risk level reduction) programs, and mechanisms for authorities' interests coordination. The book is aiming at undergraduate and postgraduate students, as well as at experts in mathematical modeling and control of ecological economic, socioeconomic and organizational systems.

  2. Biaxial mechanical characterization of bat wing skin. (United States)

    Skulborstad, A J; Swartz, S M; Goulbourne, N C


    The highly flexible and stretchable wing skin of bats, together with the skeletal structure and musculature, enables large changes in wing shape during flight. Such compliance distinguishes bat wings from those of all other flying animals. Although several studies have investigated the aerodynamics and kinematics of bats, few have examined the complex histology and mechanical response of the wing skin. This work presents the first biaxial characterization of the local deformation, mechanical properties, and fiber kinematics of bat wing skin. Analysis of these data has provided insight into the relationships among the structural morphology, mechanical properties, and functionality of wing skin. Large spatial variations in tissue deformation and non-negligible fiber strains in the cross-fiber direction for both chordwise and spanwise fibers indicate fibers should be modeled as two-dimensional elements. The macroscopic constitutive behavior was anisotropic and nonlinear, with very low spanwise and chordwise stiffness (hundreds of kilopascals) in the toe region of the stress-strain curve. The structural arrangement of the fibers and matrix facilitates a low energy mechanism for wing deployment and extension, and we fabricate examples of skins capturing this mechanism. We propose a comprehensive deformation map for the entire loading regime. The results of this work underscore the importance of biaxial field approaches for soft heterogeneous tissue, and provide a foundation for development of bio-inspired skins to probe the effects of the wing skin properties on aerodynamic performance.

  3. Dynamics and Control of a Class of Underactuated Mechanical Systems


    Reyhanoglu, Mahmut; van der Schaft, Arjan; McClamroch, N. Harris; Kolmanovsky, Ilya


    This paper presents a theoretical framework for the dynamics and control of underactuated mechanical systems, defined as systems with fewer inputs than degrees of freedom. Control system formulation of underactuated mechanical systems is addressed and a class of underactuated systems characterized by nonintegrable dynamics relations is identified. Controllability and stabilizability results are derived for this class of underactuated systems. Examples are included to illustrate the results; t...

  4. Statistical Mechanics Characterization of Neuronal Mosaics

    CERN Document Server

    Costa, Luciano da Fontoura; de Lima, Silene Maria Araujo


    The spatial distribution of neuronal cells is an important requirement for achieving proper neuronal function in several parts of the nervous system of most animals. For instance, specific distribution of photoreceptors and related neuronal cells, particularly the ganglion cells, in mammal's retina is required in order to properly sample the projected scene. This work presents how two concepts from the areas of statistical mechanics and complex systems, namely the \\emph{lacunarity} and the \\emph{multiscale entropy} (i.e. the entropy calculated over progressively diffused representations of the cell mosaic), have allowed effective characterization of the spatial distribution of retinal cells.

  5. Mechanical Characterization of Rigid Polyurethane Foams

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Wei-Yang [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Mechanics of Materials


    Foam materials are used to protect sensitive components from impact loading. In order to predict and simulate the foam performance under various loading conditions, a validated foam model is needed and the mechanical properties of foams need to be characterized. Uniaxial compression and tension tests were conducted for different densities of foams under various temperatures and loading rates. Crush stress, tensile strength, and elastic modulus were obtained. A newly developed confined compression experiment provided data for investigating the foam flow direction. A biaxial tension experiment was also developed to explore the damage surface of a rigid polyurethane foam.

  6. Mechanical Characterization of Rigid Polyurethane Foams.

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Wei-Yang


    Foam materials are used to protect sensitive components from impact loading. In order to predict and simulate the foam performance under various loading conditions, a validated foam model is needed and the mechanical properties of foams need to be characterized. Uniaxial compression and tension tests were conducted for different densities of foams under various temperatures and loading rates. Crush stress, tensile strength, and elastic modulus were obtained. A newly developed confined compression experiment provided data for investigating the foam flow direction. A biaxial tension experiment was also developed to explore the damage surface of a rigid polyurethane foam.

  7. Mechanical and Thermal Characterization of Silica Nanocomposites (United States)

    Cunningham, Anthony Lamar

    Polymer nanocomposites are a class of materials containing nanoparticles with a large interfacial surface area. Only a small quantity of nanoparticles are needed to provide superior multifunctional properties; such as mechanical, thermal, electrical, and moisture absorption properties in polymers. Nanoparticles tend to agglomerate, so special techniques are required for homogeneous distribution. Nanosilica is now readily available as colloidal sols, for example; Nanopox RTM F400 (supplied by Evonik Nanoresins AG, Germany). The nanoparticles are first synthesized from aqueous sodium silicate solution, and then undergo a surface modification process with organosilane and matrix exchange. F400 contains 40%wt silica nanoparticles colloidally dispersed in a DGEBA epoxy resin. The mean particle diameter is about 20 nm with a narrow distribution range of about 5 to 35 nm. The objectives of this study are to develop a reproducible processing method for nanosilica enhanced resin systems used in the manufacturing of fiber reinforced composites that will be characterized for mechanical and thermal properties. Research has concluded that shows improvements in the properties of the matrix material when processed in loading variations of 0 to 25%wt silica nanoparticles. The loadings were also used to manufacture fiberglass reinforced nanocomposite laminates and also tested for mechanical and thermal properties.

  8. Mechanical Characterization of Energy Materials at DTU Energy

    DEFF Research Database (Denmark)

    Tadesse Molla, Tesfaye; Han, Li; Frandsen, Henrik Lund

    go hand in hand with understanding and improving their mechanical reliability at operational conditions. With this regard, DTU energy has a dedicated team and facilities working on characterization of metallic as well as ceramic materials used in energy conversion and storage technologies. The poster......Due to the ever growing demand for sustainable energy alternatives, increasing the efficiency as well as reliability of energy conversion and storage technologies is becoming paramount challenge for the research community in the field. To achieve this, the innovation of new material systems should...... presents the unique capabilities in the department including high throughput and high temperature strength and deformational behavior characterization of materials in a controlled atmosphere. The characterization techniques mainly focus on materials being developed to be used in solid oxide fuel...

  9. Hydroxyapatite nanocrystals: Simple preparation, characterization and formation mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Mohandes, Fatemeh [Department of Inorganic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P. O. Box. 87317-51167, Islamic Republic of Iran (Iran, Islamic Republic of); Salavati-Niasari, Masoud, E-mail: [Department of Inorganic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P. O. Box. 87317-51167, Islamic Republic of Iran (Iran, Islamic Republic of); Institute of Nano Science and Nano Technology, University of Kashan, Kashan, P. O. Box 87317-51167, Islamic Republic of Iran (Iran, Islamic Republic of); Fathi, Mohammadhossein [Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 8415683111, Islamic Republic of Iran (Iran, Islamic Republic of); Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran (Iran, Islamic Republic of); Fereshteh, Zeinab [Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 8415683111, Islamic Republic of Iran (Iran, Islamic Republic of)


    Crystalline hydroxyapatite (HAP) nanoparticles and nanorods have been successfully synthesized via a simple precipitation method. To control the shape and particle size of HAP nanocrystals, coordination ligands derived from 2-hydroxy-1-naphthaldehyde were first prepared, characterized by Fourier transform infrared (FT-IR) and proton nuclear magnetic resonance ({sup 1}H-NMR) spectroscopies, and finally applied in the synthesis process of HAP. On the other hand, the HAP nanocrystals were also characterized by several techniques including powder X-ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM). According to the FE-SEM and TEM micrographs, it was found that the morphology and crystallinity of the HAP powders depended on the coordination mode of the ligands. - Highlights: • HAP nanobundles and nanoparticles have been prepared by a precipitation method. • Morphologies of HAP nanocrystals were controlled by different coordination ligands. • The formation mechanism of hydroxyapatite nanocrystals was also considered.

  10. Mechanical characterization of commercial biodegradable plastic films (United States)

    Vanstrom, Joseph R.

    Polylactic acid (PLA) is a biodegradable plastic that is relatively new compared to other plastics in use throughout industry. The material is produced by the polymerization of lactic acid which is produced by the fermentation of starches derived from renewable feedstocks such as corn. Polylactic acid can be manufactured to fit a wide variety of applications. This study details the mechanical and morphological properties of selected commercially available PLA film products. Testing was conducted at Iowa State University and in conjunction with the United States Department of Agriculture (USDA) BioPreferred ProgramRTM. Results acquired by Iowa State were compared to a similar study performed by the Cortec Corporation in 2006. The PLA films tested at Iowa State were acquired in 2009 and 2010. In addition to these two studies at ISU, the films that were acquired in 2009 were aged for a year in a controlled environment and then re-tested to determine effects of time (ageing) on the mechanical properties. All films displayed anisotropic properties which were confirmed by inspection of the films with polarized light. The mechanical testing of the films followed American Society for Testing and Materials (ASTM) standards. Mechanical characteristics included: tensile strength (ASTM D882), elongation of material at failure (ASTM D882), impact resistance (ASTM D1922), and tear resistance (ASTM D4272). The observed values amongst all the films ranged as followed: tensile strength 33.65--8.54 MPa; elongation at failure 1,665.1%--47.2%; tear resistance 3.61--0.46 N; and puncture resistance 2.22--0.28 J. There were significant differences between the observed data for a number of films and the reported data published by the Cortec Corp. In addition, there were significant differences between the newly acquired material from 2009 and 2010, as well as the newly acquired materials in 2009 and the aged 2009 materials, suggesting that ageing and manufacturing date had an effect on

  11. Characterizing Truthful Multi-Armed Bandit Mechanisms

    CERN Document Server

    Babaioff, Moshe; Slivkins, Aleksandrs


    We consider a multi-round auction setting motivated by pay-per-click auctions for Internet advertising. In each round the auctioneer selects an advertiser and shows her ad, which is then either clicked or not. An advertiser derives value from clicks; the value of a click is her private information. Initially, neither the auctioneer nor the advertisers have any information about the likelihood of clicks on the advertisements. The auctioneer's goal is to design a (dominant strategies) truthful mechanism that (approximately) maximizes the social welfare. If the advertisers bid their true private values, our problem is equivalent to the "multi-armed bandit problem", and thus can be viewed as a strategic version of the latter. In particular, for both problems the quality of an algorithm can be characterized by "regret", the difference in social welfare between the algorithm and the benchmark which always selects the same "best" advertisement. We investigate how the design of multi-armed bandit algorithms is affect...

  12. Mechanical characterization of seismic base isolation elastomers

    Energy Technology Data Exchange (ETDEWEB)

    Kulak, R.F.; Hughes, T.H.


    From the various devices proposed for seismic isolators, the laminated elastomer bearing is emerging as the preferred device for large buildings/structures, such as nuclear reactor plants. The laminated bearing is constructed from alternating thin layers of elastomer and metallic plates (shims). The elastomer is usually a carbon filled natural rubber that exhibits damping when subjected to shear. Recently, some blends of natural and synthetic rubbers have appeared. Before candidate elastomers can be used in seismic isolation bearings, their response to design-basis loads and beyond- design-basis loads must be determined. This entails the development of constitutive models and and then the determination of associated material parameters through specimen testing. This paper describes the methods used to obtain data for characterizing the mechanical response of elastomers used for seismic isolation. The data provides a data base for use in determining material parameters associated with nonlinear constitutive models. In addition, the paper presents a definition for a damping ratio that does not exhibit the usual reduction at higher strain cycles. 2 refs., 6 figs., 1 tab.

  13. Characterization of time-dependent anelastic microbeam bending mechanics (United States)

    Bergers, L. I. J. C.; Hoefnagels, J. P. M.; Geers, M. G. D.


    This paper presents an accurate yet straightforward methodology for characterizing time-dependent anelastic mechanics of thin metal films employed in metalic microelectromechanical systems (MEMS). The deflection of microbeams is controlled with a mechanical micro-clamp, measured with digital holographic microscopy and processed with global digital image correlation (GDIC). The GDIC processing directly incorporates kinematics into the three-dimensional correlation problem, describing drift-induced rigid body motion and the beam deflection. This yields beam curvature measurements with a resolution of <1.5 × 10-6 µm-1, or for films thinner than 5 µm, a strain resolution of <4 μɛ. Using a simple experimental sequence, these curvature measurements are then combined with a linear multi-mode time-dependent anelastic model and a priori knowledge of the Young's modulus. This allows the characterization of the material behaviour in the absence of an additional explicit force measurement, which simplifies the experimental setup. Using this methodology we characterize the anelasticity of 5 µm-thick Al(1 wt%)-Cu microbeams of varying microstructures over relevant timescales of 1 to 1 × 105 s and adequately predict the time and amplitude response of experiments performed for various loading conditions. This demonstrates the validity of the methodology and the suitability for thin film mechanics research for MEMS development.

  14. Turbomachinery Fluid Mechanics and Control (United States)


    ratio. Both the rotor and stator blade rows in an axial turbomachine diffuse their respective incoming flow fields. Therefore flow control both cases, but are much more efficiently investigated in the stator blade row. 3 The blade rows in axial turbomachines are most accurately...Aeroacoustics & Aeroelasticity of Turbomachines , Sept 7-11, 2003 Duke University, Burham, NC. 39 Gorrell, S.E., Okiishi, T., and Copenhaver

  15. Characterizing the mechanical behavior of the zebrafish germ layers (United States)

    Kealhofer, David; Serwane, Friedhelm; Mongera, Alessandro; Rowghanian, Payam; Lucio, Adam; Campàs, Otger

    Organ morphogenesis and the development of the animal body plan involve complex spatial and temporal control of tissue- and cell-level mechanics. A prime example is the generation of stresses by individual cells to reorganize the tissue. These processes have remained poorly understood due to a lack of techniques to characterize the local constitutive law of the material, which relates local cellular forces to the resulting tissue flows. We have developed a method for quantitative, local in vivo study of material properties in living tissue using magnetic droplet probes. We use this technique to study the material properties of the different zebrafish germ layers using aggregates of zebrafish mesendodermal and ectodermal cells as a model system. These aggregates are ideal for controlled studies of the mechanics of individual germ layers because of the homogeneity of the cell type and the simple spherical geometry. Furthermore, the numerous molecular tools and transgenic lines already developed for this model organism can be applied to these aggregates, allowing us to characterize the contributions of cell cortex tension and cell adhesion to the mechanical properties of the zebrafish germ layers.

  16. Urban Stormwater Characterization, Control, and Treatment. (United States)

    Vogel, Jason R; Moore, Trisha L


    The following review presents a synthesis of 181 journal articles published during 2015 that represent progress toward better characterizing, controlling, and treating urban stormwater runoff. The review is structured by general topical areas related to (1) stormwater quality and quantity characterization; (2) engineered stormwater control and treatment practices, including erosion and sediment control, stormwater ponds, constructed stormwater wetlands, bioretention, permeable pavement, greenroofs, and rainwater harvesting systems; and (3) watershed-scale modeling and optimization of stormwater control and treatment practices. Common research themes emerging from this collection of studies include potential to enhance hydrologic and pollutant treatment performance of stormwater practices via media amendments and the use of innovative outlet control structures, as well as development of a more mechanistic understanding of hydrologic and water-quality functions to inform modeling and performance predictions. These studies serve to expand the field's knowledge base and will inform future efforts to further improve stormwater control and treatment at various spatial and temporal scales.

  17. Mechanism and control of Genipa americana seed germination

    NARCIS (Netherlands)

    Queiroz, S.E.E.; Silva, da E.A.A.; Davide, A.C.; Jose, A.C.; Silva, A.T.; Fraiz, A.C.R.; Faria, J.M.R.; Hilhorst, H.W.M.


    Genipa americana (Rubiaceae) is important for restoration of riparian forest in the Brazilian Cerrado. The objective was to characterize the mechanism and control of germination of G. americana to support uniform seedling production. Morphology and morphometrics of seeds, embryo and endosperm were a

  18. Optimal Control of Active Recoil Mechanisms (United States)


    pressures in different chambers, rod pull are available and can be plotted. A linear state feedback control system is proposed to adapt this...desirable. A linear state feedback control system with variable gains is proposed in the report. A separate control law is designed for each...optimization algorithm to choose a feasible solution. 27 3.3 Results for M-37 Recoil Mechanism The linear state feedback control system and

  19. Development and mechanical characterization of porous titanium bone substitutes. (United States)

    Barbas, A; Bonnet, A-S; Lipinski, P; Pesci, R; Dubois, G


    Commercially Pure Porous Titanium (CPPTi) can be used for surgical implants to avoid the stress shielding effect due to the mismatch between the mechanical properties of titanium and bone. Most researchers in this area deal with randomly distributed pores or simple architectures in titanium alloys. The control of porosity, pore size and distribution is necessary to obtain implants with mechanical properties close to those of bone and to ensure their osseointegration. The aim of the present work was therefore to develop and characterize such a specific porous structure. First of all, the properties of titanium made by Selective Laser Melting (SLM) were characterized through experimental testing on bulk specimens. An elementary pattern of the porous structure was then designed to mimic the orthotropic properties of the human bone following several mechanical and geometrical criteria. Finite Element Analysis (FEA) was used to optimize the pattern. A porosity of 53% and pore sizes in the range of 860 to 1500 μm were finally adopted. Tensile tests on porous samples were then carried out to validate the properties obtained numerically and identify the failure modes of the samples. Finally, FE elastoplastic analyses were performed on the porous samples in order to propose a failure criterion for the design of porous substitutes.

  20. Mechanics and aerodynamics of insect flight control. (United States)

    Taylor, G K


    Insects have evolved sophisticated fight control mechanisms permitting a remarkable range of manoeuvres. Here, I present a qualitative analysis of insect flight control from the perspective of flight mechanics, drawing upon both the neurophysiology and biomechanics literatures. The current literature does not permit a formal, quantitative analysis of flight control, because the aerodynamic force systems that biologists have measured have rarely been complete and the position of the centre of gravity has only been recorded in a few studies. Treating the two best-known insect orders (Diptera and Orthoptera) separately from other insects, I discuss the control mechanisms of different insects in detail. Recent experimental studies suggest that the helicopter model of flight control proposed for Drosophila spp. may be better thought of as a facultative strategy for flight control, rather than the fixed (albeit selected) constraint that it is usually interpreted to be. On the other hand, the so-called 'constant-lift reaction' of locusts appears not to be a reflex for maintaining constant lift at varying angles of attack, as is usually assumed, but rather a mechanism to restore the insect to pitch equilibrium following a disturbance. Differences in the kinematic control mechanisms used by the various insect orders are related to differences in the arrangement of the wings, the construction of the flight motor and the unsteady mechanisms of lift production that are used. Since the evolution of insect flight control is likely to have paralleled the evolutionary refinement of these unsteady aerodynamic mechanisms, taxonomic differences in the kinematics of control could provide an assay of the relative importance of different unsteady mechanisms. Although the control kinematics vary widely between orders, the number of degrees of freedom that different insects can control will always be limited by the number of independent control inputs that they use. Control of the moments

  1. Mechanical engineers' handbook, design, instrumentation, and controls

    CERN Document Server

    Kutz, Myer


    Full coverage of electronics, MEMS, and instrumentation andcontrol in mechanical engineering This second volume of Mechanical Engineers' Handbookcovers electronics, MEMS, and instrumentation and control, givingyou accessible and in-depth access to the topics you'll encounterin the discipline: computer-aided design, product design formanufacturing and assembly, design optimization, total qualitymanagement in mechanical system design, reliability in themechanical design process for sustainability, life-cycle design,design for remanufacturing processes, signal processing, dataacquisition and dis

  2. Characterization of esophageal physiology using mechanical state analysis

    Directory of Open Access Journals (Sweden)

    Richard Eduard Leibbrandt


    Full Text Available The esophagus functions to transport swallowed fluids and food from the pharynx to the stomach. The esophageal muscles governing bolus transport comprise circular striated muscle of the proximal esophagus and circular smooth muscle of the distal esophagus. Longitudinal smooth muscle contraction provides a mechanical advantage to bolus transit during circular smooth muscle contraction. Esophageal striated muscle is directly controlled by neural circuits originating in the central nervous system, resulting in coordinated contractions. In contrast, the esophageal smooth muscle is controlled by enteric circuits modulated by extrinsic central neural connections resulting in neural relaxation and contraction. The esophageal muscles are modulated by sensory information arising from within the lumen. Contraction or relaxation, which changes the diameter of the lumen, alters the intraluminal pressure and ultimately inhibits or promotes flow of content. This relationship that exists between the changes in diameter and concurrent changes in intraluminal pressure has been used previously to identify the ‘mechanical states’ of the circular muscle; that is when the muscles are passively or actively, relaxing or contracting. Detecting these changes in the mechanical state of the muscle has been difficult and, as the current interpretation of esophageal motility is based largely upon pressure measurement (manometry, subtle changes in the muscle function during peristalsis can be missed. We hypothesized that quantification of mechanical states of the esophageal circular muscles and the pressure-diameter properties that define them, would allow objective characterization of the mechanisms that govern esophageal peristalsis. To achieve this we analyzed barium swallows captured by simultaneous videofluoroscopy and pressure with impedance recording. From these data we demonstrated that intraluminal impedance measurements could be used to determine changes in the

  3. A characterization of 2-player mechanisms for scheduling

    CERN Document Server

    Christodoulou, George; Vidali, Angelina


    We study the mechanism design problem of scheduling unrelated machines and we completely characterize the decisive truthful mechanisms for two players when the domain contains both positive and negative values. We show that the class of truthful mechanisms is very limited: A decisive truthful mechanism partitions the tasks into groups so that the tasks in each group are allocated independently of the other groups. Tasks in a group of size at least two are allocated by an affine minimizer and tasks in singleton groups by a task-independent mechanism. This characterization is about all truthful mechanisms, including those with unbounded approximation ratio. A direct consequence of this approach is that the approximation ratio of mechanisms for two players is 2, even for two tasks. In fact, it follows that for two players, VCG is the unique algorithm with optimal approximation 2. This characterization provides some support that any decisive truthful mechanism (for 3 or more players) partitions the tasks into gro...

  4. Microstructural and mechanical characterization of Al–Zn–Si nanocomposites

    Energy Technology Data Exchange (ETDEWEB)

    García-Villarreal, S. [Centro de Investigación en Materiales Avanzados S.C. Monterrey, 66600, Alianza Nte. 202, Parque PIIT, Apodaca, N.L. (Mexico); Chávez-Valdez, A. [Katcon Institute for Innovation and Technology KIIT, 66629, Alianza Sur 200, Apodaca, N.L. (Mexico); Moreno, K.J. [Instituto Tecnológico de Celaya, Apartado Postal 57, 38010 Celaya, Guanajuato (Mexico); Leyva, C.; Aguilar-Martínez, J.A. [Centro de Investigación en Materiales Avanzados S.C. Monterrey, 66600, Alianza Nte. 202, Parque PIIT, Apodaca, N.L. (Mexico); Hurtado, A. [Centro de Investigación en Materiales Avanzados S.C., 31109, Miguel de Cervantes 120, Chih., Chih. (Mexico); Arizmendi-Morquecho, A., E-mail: [Centro de Investigación en Materiales Avanzados S.C. Monterrey, 66600, Alianza Nte. 202, Parque PIIT, Apodaca, N.L. (Mexico)


    In this paper the addition of silicon nanoparticles into Al–Zn alloys to form metallic matrix nanocomposites by mechanical alloying process was investigated. The influence of various process parameters such as milling time and Si concentration in the Al–Zn matrix has an interesting effect on the microstructure and mechanical properties of the synthesized nanocomposites. The microstructural characterization of the nanocomposites was evaluated by transmission electron microscopy and energy dispersive X-ray spectroscopy (TEM–EDXS) and the mechanical properties were measured by nanoindentation and micro-hardness tests. The results showed that during mechanical milling Si is added to the Al–Zn matrix achieving a uniform and homogeneous dispersion. After solidification, it forms small particles of AlZnSi with blocky morphology in interdendritic regions. The nanoindentation profiles showed that the elastic modulus and hardness properties increase with increasing milling time. However, a high concentration of Si (> 1.2 wt.%) results in a saturation of Si in the Al–Zn matrix, which adversely affects the mechanical properties. Thus, it is important to tune the milling time and concentration of Si added to the Al–Zn alloys to control the growth of brittle phases that result in reduction of the mechanical properties of the material. - Highlights: • A novel technique for addition of Si nanocomposites into Al–Zn liquid alloy is reported. • Good dispersion and homogeneity of Si in the Al–Zn matrix are obtained. • Increasing Si content above 1.2 wt.% decreases the mechanical properties of Al–Zn alloy. • The saturation point of Si in 1.2 wt.% differs from Galvalume® composition. • The Al–Zn–1.5Si alloy with addition of nanocomposite shows 5.7 GPa of hardness.

  5. Integrated design approach for controlled mechanical structures

    Energy Technology Data Exchange (ETDEWEB)

    Kiriazov, P. [Bulgarian Academy of Sciences, Sofia (Bulgaria). Inst. of Mechanics


    This study is addressed to design problems of controlled mechanical structures (CMS) like robot manipulators and engineering systems with active vibration control that may be subject to arbitrary disturbances. Along with the basic design requirement for strength/load capacity, additional design criteria for CMS are needed to meet the continuously increasing demands for faster response, improved precision and reduced energy consumption. As a CMS is a functionally directed assembly of mutually influencing components: control, actuator, mechanical, and sensor subsystems, a conceptual framework for their integrated design is required. Parameters of these subsystems influencing the dynamic performance of CMS define a matrix that transfers the control inputs into the controlled outputs (accelerations). This transfer matrix plays the key role in the integrated structure-control design. We consider the design optimization problem for CMS having decentralized control architecture. An integrated design criterion for such systems is proposed which is based on optimal trade-off relations between bounds of model uncertainties and control force limits. Optimizing this criterion leads to CMS with maximum degree of robustness. The approach proposed makes it possible a decomposition of the overall design problem into design problems for the CMS`s components. The design concepts are applied to the mechanical subsystem of planar linkage systems. Robust decentralized controllers are designed for a two-degree-of-freedom manipulator with elastic joints. (orig.)

  6. Characterizing the mechanism(s) of heavy element synthesis reactions (United States)

    Loveland, Walter


    A review of the current state of our understanding of complete fusion reaction mechanisms is presented, from the perspective of an experimentalist. For complete fusion reactions, the overall uncertainties in predicting heavy element synthesis cross sections are examined in terms of the uncertainties associated with the calculations of capture cross sections, fusion probabilities and survival probabilities.

  7. Thermo-mechanical characterization of silicone foams

    Energy Technology Data Exchange (ETDEWEB)

    Rangaswamy, Partha [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Smith, Nickolaus A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Cady, Carl M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lewis, Matthew W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    Cellular solids such as elastomeric foams are used in many structural applications to absorb and dissipate energy, due to their light weight (low density) and high energy absorption capability. In this paper we will discuss foams derived from S5370, a silicone foam formulation developed by Dow Corning. In the application presented, the foam is consolidated into a cushion component of constant thickness but variable density. A mechanical material model developed by Lewis (2013), predicts material response, in part, as a function of relative density. To determine the required parameters for this model we have obtained the mechanical response in compression for ambient, cold and hot temperatures. The variable density cushion provided samples sufficient samples so that the effect of sample initial density on the mechanical response could be studied. The mechanical response data showed extreme sensitivity to relative density. We also observed at strains corresponding to 1 MPa a linear relationship between strain and initial density for all temperatures. Samples taken from parts with a history of thermal cycling demonstrated a stiffening response that was a function of temperature, with the trend of more stiffness as temperature increased above ambient. This observation is in agreement with the entropic effects on the thermo-mechanical behavior of silicone polymers. In this study, we present the experimental methods necessary for the development of a material model, the testing protocol, analysis of test data, and a discussion of load (stress) and gap (strain) as a function of sample initial densities and temperatures

  8. Analysis and control of underactuated mechanical systems

    CERN Document Server

    Choukchou-Braham, Amal; Djemaï, Mohamed; Busawon, Krishna


    This monograph provides readers with tools for the analysis, and control of systems with fewer control inputs than degrees of freedom to be controlled, i.e., underactuated systems. The text deals with the consequences of a lack of a general theory that would allow methodical treatment of such systems and the ad hoc approach to control design that often results, imposing a level of organization whenever the latter is lacking. The authors take as their starting point the construction of a graphical characterization or control flow diagram reflecting the transmission of generalized forces through the degrees of freedom. Underactuated systems are classified according to the three main structures by which this is found to happen—chain, tree, and isolated vertex—and control design procedures proposed. The procedure is applied to several well-known examples of underactuated systems: acrobot; pendubot; Tora system; ball and beam; inertia wheel; and robotic arm with elastic joint. The text is illustrated with MATL...

  9. Damage-mitigating control of mechanical systems (United States)

    Holmes, Michael S.

    Damage-Mitigating Control is a field of research involving the integration of two distinct disciplines: Systems Sciences and Mechanics of Materials. This dissertation presents a feedback control architecture for mechanical systems to achieve a tradeoff between dynamic performance and structural durability of critical plant components. The proposed damage-mitigating control system has a two-tier structure: (i) A lower-level linear output feedback controller for plant output tracking and stability robustness over a specified operating range; and (ii) An upper-level nonlinear feedback controller which takes advantage of the real-time information generated by a physics-based model of material damage. The advantages and disadvantages of various methods available for the design of linear tracking controllers are discussed. A robust sampled-data Hsbinfty controller is designed for a reusable rocket engine, similar to the Space Shuttle Main Engine, based on a 2-input/2-output, 20-state model. The mu-synthesis technique is used to design a robust sampled-data controller for a commercial-scale fossil-fueled power plant based on a 4-input/4-output, 27-state model. A procedure for the design of damage-mitigating linear tracking controllers is also presented. The concept of fuzzy control is used to synthesize upper-level nonlinear feedback controllers based on real-time damage information. Damage-mitigating controllers are designed for the reusable rocket engine and the fossil-fueled power plant. A major advantage of using the fuzzy method for damage-mitigating controller design is that the controller can be synthesized without directly dealing with the inherent nonlinearities of the damage model. Simulation results for the reusable rocket engine and the fossil-fueled power plant suggest that the fuzzy method of damage mitigation is a practical way to design damage controllers for mechanical systems. The damage controller parameter optimization method is presented as an

  10. Mechanical property characterization of intraply hybrid composites (United States)

    Chamis, C. C.; Lark, R. F.; Sinclair, J. H.


    An investigation of the mechanical properties of intraply hybrids made from graphite fiber/epoxy matrix hybridized with secondary S-glass or Kevlar 49 fiber composites is presented. The specimen stress-strain behavior was determined, showing that mechanical properties of intraply hybrid composites can be measured with available methods such as the ten-degree off-axis test for intralaminar shear, and conventional tests for tensile, flexure, and Izod impact properties. The results also showed that combinations of high modulus graphite/S-glass/epoxy matrix composites exist which yield intraply hybrid laminates with the best 'balanced' properties, and that the translation efficiency of mechanical properties from the constituent composites to intraply hybrids may be assessed with a simple equation.

  11. Preliminary statistical assessment towards characterization of biobotic control. (United States)

    Latif, Tahmid; Meng Yang; Lobaton, Edgar; Bozkurt, Alper


    Biobotic research involving neurostimulation of instrumented insects to control their locomotion is finding potential as an alternative solution towards development of centimeter-scale distributed swarm robotics. To improve the reliability of biobotic agents, their control mechanism needs to be precisely characterized. To achieve this goal, this paper presents our initial efforts for statistical assessment of the angular response of roach biobots to the applied bioelectrical stimulus. Subsequent findings can help to understand the effect of each stimulation parameter individually or collectively and eventually reach reliable and consistent biobotic control suitable for real life scenarios.

  12. Novel routes to nanocrystalline mechanical characterization (United States)

    Cordill, M. J.; Mook, W. M.; Nair, A. K.; Farkas, D.; Gerberich, W. W.


    The use of nanoindentation techniques to measure nanoscale mechanical behavior is a new path of interest to researchers today. Load drops and displacement excursions can be utilized to measure activation volumes for dislocation events in single crystals, thin films, and nanoposts. Through the introduction of a new length-scale parameter, the dislocation wall spacing, a mechanism describing staircase yielding, is presented. The dislocation wall spacing can also be used to estimate activation volumes. Molecular dynamics simulations of nickel film indentation have been used to validate the origin of staircase yielding and also show consistent dislocation wall spacings. Additionally, stress relaxation experiments have been used to estimate activation volumes.

  13. Nonsmooth mechanics models, dynamics and control

    CERN Document Server

    Brogliato, Bernard


    Now in its third edition, this standard reference is a comprehensive treatment of nonsmooth mechanical systems refocused to give more prominence to control and modelling. It covers Lagrangian and Newton–Euler systems, detailing mathematical tools such as convex analysis and complementarity theory. The ways in which nonsmooth mechanics influence and are influenced by well-posedness analysis, numerical analysis and simulation, modelling and control are explained. Contact/impact laws, stability theory and trajectory-tracking control are given in-depth exposition connected by a framework formed from complementarity systems and measure-differential inclusions. Links are established with electrical circuits with set-valued nonsmooth elements and with other nonsmooth dynamical systems like impulsive and piecewise linear systems. Nonsmooth Mechanics (third edition) has been substantially rewritten, edited and updated to account for the significant body of results that have emerged in the twenty-first century—incl...

  14. Mechanical characterization and modeling of curing thermosets

    NARCIS (Netherlands)

    Van 't Hof, C.


    Chemical shrinkage and simultaneous build-up of mechanical properties in curing thermosets leads to the build-up of residual stresses and strains. Depending on the constraints these may cause interface failure, dimensional inaccuracy or failure in the thermoset or its surrounding structure. The pre

  15. [Nitrogen metabolism and its control mechanisms]. (United States)

    Bergner, H


    N intake in the form of protein has neither got an upper nor a lower limit for agricultural working animals within a diet and there is no control mechanism for it. A high surplus of certain amino acids results in a reduction of feed intake. N excretion in faeces depends on 1) the excretion of N containing indigestible feedstuffs, 2) bacterial nitrogen synthesis in the large intestine and 3) the excretion of true endogenous N containing substances (digestion enzymes, intestinal epithelium, N containing endogenous secretion). There are no other control mechanisms for N excretion in faeces. N excretion in urine mainly comprises the nitrogen from the degeneration of amino acids and nucleic acids. The interrelations between urea, NH3, allantoin, creatine and creatinine, uric acid and hippuric acid depend on the species (monogastric or ruminants), on the nitrogen and N amount consumed and on the recycling ratio of the amino acids. The absolute amount of N excretion is not subject to any control mechanism, it depends on the intake of protein and NPN substances, the interim stages, however, which lead to the formation of excretory products, are intermediately controlled. The most important interim stage is protein biosynthesis, which is a fixed, intermediately controlled value in maintenance level. Under growth conditions only, the protein synthesis quota can exceed the protein degradation quota of the total organism (positive N balance). The control mechanisms of protein biosynthesis have, according to current knowledge, the following structure: Stimulation: 1) growth hormone (STH) stimulates protein synthesis by means of somatomedins; 2) hormones of the thyroid gland (T4 and T3) are controlled by the hormone stimulating the thyroid gland (TSH); 3) insulin. Inhibition: 1) somatostatin inhibits STH, TSH and insulin; 2) cortisol directly inhibits protein synthesis and stimulates protein degradation. The control mechanisms of protein turnover in addition to genetic coding

  16. Buffet Characterization and Control for Turbulent Wings


    Dandois, J.; Molton, P.; Lepage, A.; Geeraert, A.; Brunet, V.; Dor, J.B.; Coustols, E.


    International audience; The objective of this paper is to present an overview of the work performed at Onera over the last decade on the characterization and control of the buffet phenomenon.This aerodynamic instability induces strong wall pressure fluctuations and as such limits aircraft envelope, consequently it is interesting to understand the origin of this instability and to try to delay its onset, in order to improve aircraft performance, but also to provide more flexibility during the ...

  17. Mechanical Response of DNA–Nanoparticle Crystals to Controlled Deformation (United States)


    The self-assembly of DNA-conjugated nanoparticles represents a promising avenue toward the design of engineered hierarchical materials. By using DNA to encode nanoscale interactions, macroscale crystals can be formed with mechanical properties that can, at least in principle, be tuned. Here we present in silico evidence that the mechanical response of these assemblies can indeed be controlled, and that subtle modifications of the linking DNA sequences can change the Young’s modulus from 97 kPa to 2.1 MPa. We rely on a detailed molecular model to quantify the energetics of DNA–nanoparticle assembly and demonstrate that the mechanical response is governed by entropic, rather than enthalpic, contributions and that the response of the entire network can be estimated from the elastic properties of an individual nanoparticle. The results here provide a first step toward the mechanical characterization of DNA–nanoparticle assemblies, and suggest the possibility of mechanical metamaterials constructed using DNA. PMID:27725959

  18. Simple micromechanical model of protein crystals for their mechanical characterizations

    Directory of Open Access Journals (Sweden)

    Na S.


    Full Text Available Proteins have been known to perform the excellent mechanical functions and exhibit the remarkable mechanical properties such as high fracture toughness in spider silk protein [1]. This indicates that the mechanical characterization of protein molecules and/or crystals is very essential to understand such remarkable mechanical function of protein molecules. In this study, for gaining insight into mechanical behavior of protein crystals, we developed the micromechanical model by using the empirical potential field prescribed to alpha carbon atoms of a protein crystal in a unit cell. We consider the simple protein crystals for their mechanical behavior under tensile loading to be compared with full atomic models

  19. Anelastic Relaxation Mechanisms Characterization by Moessbauer Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Soberon Mobarak, Martin Jesus, E-mail: [Secretaria de Educacion Publica (Mexico)


    Anelastic behavior of crystalline solids is generated by several microstructural processes. Its experimental study yields valuable information about materials, namely: modulus, dissipation mechanisms and activation enthalpies. However, conventional techniques to evaluate it are complicated, expensive, time consuming and not easily replicated. As a new approach, in this work a Moessbauer spectrum of an iron specimen is obtained with the specimen at repose being its parameters the 'base parameters'. After that, the same specimen is subjected to an alternated stress-relaxation cycle at frequency {omega}{sub 1} and a new Moessbauer spectrum is obtained under this excited condition; doing the same at several increasing frequencies {omega}{sub n} in order to scan a wide frequencies spectrum. The differences between the Moessbauer parameters obtained at each excitation frequency and the base parameters are plotted against frequency, yielding an 'anelastic spectrum' that reveals the different dissipation mechanisms involved, its characteristic frequency and activation energy. Results are in good agreement with the obtained with other techniques

  20. Controllability for single-input mechanical control systems with dissipation

    Institute of Scientific and Technical Information of China (English)

    Jianling KANG; Hong WANG; Huawen YE


    Within the affine connection framework of Lagrangian control systems,based on the results of Sussmann on small-time locally controllability of single-input affine nonlinear control systems,the controllability results for mechanical control systems with single-input are extended to the case of the systems with isotropic damping,where the Lagrangian is the kinetic energy associated with a Riemannian metric.A sufficient condition of negative small-time locally controllability for the system is obtained.Then,it is demonstrated that such systems are small-time locally configuration controllable if and only if the dimension of the configuration manifold is one.Finally,two examples are given to illustrate the results.Lie bracketting of vector fields and the symmetric product show the advantages in the discussion.

  1. Notions of controllability for quantum mechanical systems

    CERN Document Server

    Albertini, F


    In this paper, we define four different notions of controllability of physical interest for multilevel quantum mechanical systems. These notions involve the possibility of driving the evolution operator as well as the state of the system. We establish the connections among these different notions as well as methods to verify controllability. The paper also contains results on the relation between the controllability in arbitrary small time of a system varying on a compact transformation Lie group and the corresponding system on the associated homogeneous space. As an application, we prove that, for the system of two interacting spin 1/2 particles, not every state transfer can be obtained in arbitrary small time.

  2. Stress controls the mechanics of collagen networks. (United States)

    Licup, Albert James; Münster, Stefan; Sharma, Abhinav; Sheinman, Michael; Jawerth, Louise M; Fabry, Ben; Weitz, David A; MacKintosh, Fred C


    Collagen is the main structural and load-bearing element of various connective tissues, where it forms the extracellular matrix that supports cells. It has long been known that collagenous tissues exhibit a highly nonlinear stress-strain relationship, although the origins of this nonlinearity remain unknown. Here, we show that the nonlinear stiffening of reconstituted type I collagen networks is controlled by the applied stress and that the network stiffness becomes surprisingly insensitive to network concentration. We demonstrate how a simple model for networks of elastic fibers can quantitatively account for the mechanics of reconstituted collagen networks. Our model points to the important role of normal stresses in determining the nonlinear shear elastic response, which can explain the approximate exponential relationship between stress and strain reported for collagenous tissues. This further suggests principles for the design of synthetic fiber networks with collagen-like properties, as well as a mechanism for the control of the mechanics of such networks.

  3. Control of Compliant Mechanisms with Large Deflections (United States)

    Kern, D.; Bauer, J.; Seemann, W.

    Very often elastic joints are used in high precision applications. In the case of rotational joints flexure hinges do have some advantages compared to conventional ones. However, the most important disadvantages are the complicated and complex kinematics and kinetics. As consequence, the control of mechanisms comprised of flexure hinges gets more difficult. The strategy pursued here is to reduce flexure hinges to pseudo rigid-body systems that fit into the elaborated framework of multi-body dynamics, in particular pre-control in combination with a feedback controller. The inherent deviations of these reduced models are described as uncertainties. Methods from robust control are used to synthesize controllers for such systems with uncertainty. The procedure is illustrated by examining an example of a single flexure hinge (leaf spring type).

  4. Mechanical Characterization of Nodular Ductile Iron

    Energy Technology Data Exchange (ETDEWEB)

    Springer, H K


    The objective of this study is to characterize the strength and fracture response of nodular ductile iron (NDI) and its underlying ferritic matrix phase. Quasistatic and split Hopkinson pressure bar (SHPB) compression tests were performed on NDI and a model material for the NDI matrix phase (Fe-Si alloy). Smooth and notch round bar (NRB) samples were loaded in tension until fracture to determine strain-at-failure with varying stress triaxiality. Multiple tests were performed on each small and large smooth bar samples to obtain fracture statistics with sample size. Fracture statistics are important for initializing simulations of fragmentation events. Johnson-Cook strength models were developed for the NDI and the Fe-Si alloy. NDI strength model parameters are: A = 525 MPa, B = 650 MPa, n = 0.6, and C = 0.0205. The average SHPB experimental strain-rate of 2312/s was used for the reference strain-rate in this model. Fe-Si alloy strength model parameters are: A=560 MPa, B = 625 MPa, n = 0.5, and C = 0.02. The average SHPB experimental strain-rate of 2850/s was used for the reference strain-rate in this model. A Johnson-Cook failure model was developed for NDI with model parameters: D{sub 1} = 0.029, D{sub 2} = 0.44, D{sub 3} = -1.5, and D{sub 4} = D{sub 5} = 0. An exponential relationship was developed for the elongation-at-failure statistics as a function of length-scale with model parameters: S{sub f1} = 0.108, S{sub f2} = -0.00169, and L{sub m} = 32.4 {mu}m. NDI strength and failure models, including failure statistics, will be used in continuum-scale simulations of explosively-driven ring fragmentation. The Fe-Si alloy strength model will be used in mesoscale simulations of spall fracture in NDI, where the NDI matrix phase is captured explicitly.

  5. Fully Mechanically Controlled Automated Electron Microscopic Tomography (United States)

    Liu, Jinxin; Li, Hongchang; Zhang, Lei; Rames, Matthew; Zhang, Meng; Yu, Yadong; Peng, Bo; Celis, César Díaz; Xu, April; Zou, Qin; Yang, Xu; Chen, Xuefeng; Ren, Gang


    Knowledge of three-dimensional (3D) structures of each individual particles of asymmetric and flexible proteins is essential in understanding those proteins’ functions; but their structures are difficult to determine. Electron tomography (ET) provides a tool for imaging a single and unique biological object from a series of tilted angles, but it is challenging to image a single protein for three-dimensional (3D) reconstruction due to the imperfect mechanical control capability of the specimen goniometer under both a medium to high magnification (approximately 50,000–160,000×) and an optimized beam coherence condition. Here, we report a fully mechanical control method for automating ET data acquisition without using beam tilt/shift processes. This method could reduce the accumulation of beam tilt/shift that used to compensate the error from the mechanical control, but downgraded the beam coherence. Our method was developed by minimizing the error of the target object center during the tilting process through a closed-loop proportional-integral (PI) control algorithm. The validations by both negative staining (NS) and cryo-electron microscopy (cryo-EM) suggest that this method has a comparable capability to other ET methods in tracking target proteins while maintaining optimized beam coherence conditions for imaging.

  6. Quality control of injection moulded micro mechanical parts

    DEFF Research Database (Denmark)

    Gasparin, Stefania; Tosello, Guido; Hansen, Hans Nørgaard


    Quality control of micro components is an increasing challenge. Smaller mechanical parts are characterized by smaller tolerance to be verified. This paper focuses on the dimensional verification of micro injection moulded components selected from an industrial application. These parts are measured...... using an Optical Coordinate Measuring Machine (OCMM), which guarantees fast surface scans suitable for in line quality control. The uncertainty assessment of the measurements is calculated following the substitution method. To investigate the influence parameters in optical coordinate metrology two...... analyses are carried out and discussed. The estimation of the total variability of optical measurements and instrument repeatability are reported....

  7. Concurrency Control Mechanism of Complex Objects

    Institute of Scientific and Technical Information of China (English)

    徐庆云; 王能斌


    A complex object is an abstraction and description of a complex entity of the real world.Many applications in such domains as CIMS,CAD and OA define and manipulate a complex object as a single unit.In this paper,a definition of the model of complex objects is given,and the concurrency control mechanism of complex objects in WHYMX object-oriented database system is described.

  8. Development of Mechanical Water Level Controller


    Akonyi Nasiru Sule; Chinedu Cletus Obinwa; Christian Ebele Okekeze; Eyo Ifreke


    The automatic water level controller is a device designed to regulate automatically the pumping of water to an overhead tank without allowing the water in the tank to be exhausted. The design of this mechanical device was achieved using the Archimedes principle of floatation; having a float which determines the water level in the tank depending on the choice of the minimum (lower) and maximum (upper) level inscribed in the tank. The fundamental attribute of this device is the ease in design, ...

  9. New Interference Mechanism Controls Ultracold Chemistry (United States)

    Kendrick, Brian K.; Hazra, Jisha; Balakrishnan, N.


    A newly discovered interference mechanism has been shown to control the outcome of ultracold chemical reactions. The mechanism originates from the unique properties associated with ultracold collisions, namely: (1) isotropic (s-wave) scattering and (2) an effective quantization of the scattering phase shift (which originates from the bound state structure of the molecule). These two properties can lead to maximum constructive or destructive interference between two interfering reaction pathways (such as exchange and non-exchange in systems with two or more identical nuclei). If the molecular system exhibits a conical intersection, then the associated geometric phase is shown to act as a ``quantum switch'' which can turn the reactivity on or off. Reaction rate coefficients for the O + OH --> H + O2 and H + H2, reactions are presented which explicitly demonstrate the effect. Experimentalists might exploit this new mechanism to control ultracold reactions by the application of external electric or magnetic fields or by the selection of a particular nuclear spin state. This work was supported in part by the LDRD program (Grant No. 20140309ER) at LANL (B.K.) and by NSF Grant PHY-1505557 (N.B.) and ARO MURI Grant No. W911NF-12-1-0476 (N.B.).

  10. Quantitative characterization of toughening mechanisms of rubber modified polymers

    Institute of Scientific and Technical Information of China (English)

    朱晓光; 漆宗能; 徐虎; 李刚; 蔡忠龙; C.L.Choy


    The volume changes of rubber modified polymers under creep at room temperature were successfully used to characterize the toughening mechanisms of blends with brittle polymer matrices such as high impact polystyrene.This approach cannot be applied to pseudo-ductile polymers such as polypropylene and polyamide,because they are ductile when stretched at low speed at room temperature.Based on the time-temperature equivalence princi ple,the volume change at low temperature is proposed to characterize quantitatively the toughening mechanisms of polymer blends with ductile matrices,which is illustrated by applying this approach to rubber modified polypropylene

  11. Control mechanisms in mitochondrial oxidative phosphorylation

    Institute of Scientific and Technical Information of China (English)

    Jana Hroudová; Zdeněk Fi(s)ar


    Distribution and activity of mitochondria are key factors in neuronal development, synaptic plasticity and axogenesis. The majority of energy sources, necessary for cellular functions, originate from oxidative phosphorylation located in the inner mitochondrial membrane. The adenosine-5'- triphosphate production is regulated by many control mechanism–firstly by oxygen, substrate level, adenosine-5'-diphosphate level, mitochondrial membrane potential, and rate of coupling and proton leak. Recently, these mechanisms have been implemented by "second control mechanisms," such as reversible phosphorylation of the tricarboxylic acid cycle enzymes and electron transport chain complexes, allosteric inhibition of cytochrome c oxidase, thyroid hormones, effects of fatty acids and uncoupling proteins. Impaired function of mitochondria is implicated in many diseases ranging from mitochondrial myopathies to bipolar disorder and schizophrenia. Mitochondrial dysfunctions are usually related to the ability of mitochondria to generate adenosine-5'-triphosphate in response to energy demands. Large amounts of reactive oxygen species are released by defective mitochondria, similarly, decline of antioxidative enzyme activities (e.g. in the elderly) enhances reactive oxygen species production. We reviewed data concerning neuroplasticity, physiology, and control of mitochondrial oxidative phosphorylation and reactive oxygen species production.

  12. Stirling engine control mechanism and method (United States)

    Dineen, John J.


    A reciprocating-to-rotating motion conversion and power control device for a Stirling engine includes a hub mounted on an offset portion of the output shaft for rotation relative to the shaft and for sliding motion therealong which causes the hub to tilt relative to the axis of rotation of the shaft. This changes the angle of inclination of the hub relative to the shaft axis and changes the axial stroke of a set of arms connected to the hub and nutating therewith. A hydraulic actuating mechanism is connected to the hub for moving its axial position along the shaft. A balancing wheel is linked to the hub and changes its angle of inclination as the angle of inclination of the hub changes to maintain the mechanism in perfect balance throughout its range of motion.

  13. Development of Mechanical Water Level Controller

    Directory of Open Access Journals (Sweden)

    Akonyi Nasiru Sule


    Full Text Available The automatic water level controller is a device designed to regulate automatically the pumping of water to an overhead tank without allowing the water in the tank to be exhausted. The design of this mechanical device was achieved using the Archimedes principle of floatation; having a float which determines the water level in the tank depending on the choice of the minimum (lower and maximum (upper level inscribed in the tank. The fundamental attribute of this device is the ease in design, fabrication and mounting at a lower cost. Its testing had shown and proved that it works efficiently with Archimedes’ principle of floatation. This eliminates the frequent human intervention/monitoring of the water level in the overhead tank to control overflow manually, thereby eliminating water and energy wastages.

  14. Pneumatic, PLC Controlled, Automotive Gear Shifting Mechanism

    Directory of Open Access Journals (Sweden)

    Muntaser Momani


    Full Text Available In this study, a gear shifting mechanism was designed and applied to make the shifting process faster and less destructible for the driver. The new device must be reliable, has a small dimensions, low construction and maintenance cost. This paper aims to improve gear shifting process using devices as: a manual four speed gear box, four pneumatic double acting cylinders, four pneumatic two position five ways directional control valves, Programmable Logic Controller (PLC LOGO unit, an electrical motor, an electrical clutch, a belt, two pulleys, limit switches, push buttons, bulbs, a table (holder and power supply. According to suggested gear_ shifting method the driver can select the transmission gear ratio without moving his hands from the steering wheel by putting the gear shifting push buttons on the steering wheel. Using this method leaves to the driver the excitement of choosing the shifting moment.

  15. Dynamic Discontinuous Control for Active Control of Mechanical Vibrations

    Directory of Open Access Journals (Sweden)

    Orestes Llanes Santiago


    Full Text Available This article shows the use of the discontinuous control using dynamic sliding modes for the active isolation of vibrations in mechanical systems. This type of control law constitutes a robust feedback control policy due to its insensitivity to external disturbance inputs, certain immunity to model parameter variations, within known bounds, and to the ever present modelling errors.  The whole theoretical analysis is applied to a lineal model of two degrees of freedom of the vehicle's suspension where the irregularities of the land represent of direct  way the external interferences to the system . To carry out the isolation an electro-hydraulic operator it is used. Simulations are performed which validate the proposed approach.

  16. Gain control mechanisms in spinal motoneurons

    Directory of Open Access Journals (Sweden)

    Michael David Johnson


    Full Text Available Motoneurons provide the only conduit for motor commands to reach muscles. For many years, motoneurons were in fact considered to be little more than passive wires. Systematic studies in the past 25 years however have clearly demonstrated that the intrinsic electrical properties of motoneurons are under strong neuromodulatory control via multiple sources. The discovery of potent neuromodulation from the brainstem and its ability to change the gain of motoneurons shows that the passive view of the motor output stage is no longer tenable. A mechanism for gain control at the motor output stage makes good functional sense considering our capability of generating an enormous range of forces, from very delicate (e.g. putting in a contact lens to highly forceful (emergency reactions. Just as sensory systems need gain control to deal with a wide dynamic range of inputs, so to might motor output need gain control to deal with the wide dynamic range of the normal movement repertoire. Two problems emerge from the potential use of the brainstem monoaminergic projection to motoneurons for gain control. First, the projection is highly diffuse anatomically, so that independent control of the gains of different motor pools is not feasible. In fact, the system is so diffuse that gain for all the motor pools in a limb likely increases in concert. Second, if there is a system that increases gain, probably a system to reduce gain is also needed. In this review, we summarize recent studies that show local inhibitory circuits within the spinal cord, especially reciprocal and recurrent inhibition, have the potential to solve both of these problems as well as constitute another source of gain modulation.

  17. Herbicide resistance in weeds: Survey, characterization, and mechanisms (United States)

    The goal of this paper is to present a systematic diagnostic approach towards the characterization of herbicide resistance in a given weed population with regards to profile (single, multiple, cross resistance), magnitude (fold level), mechanism, and related bio-physiological aspects. Diagnosing her...

  18. Dynamic congestion control mechanisms for MPLS networks (United States)

    Holness, Felicia; Phillips, Chris I.


    Considerable interest has arisen in congestion control through traffic engineering from the knowledge that although sensible provisioning of the network infrastructure is needed, together with sufficient underlying capacity, these are not sufficient to deliver the Quality of Service required for new applications. This is due to dynamic variations in load. In operational Internet Protocol (IP) networks, it has been difficult to incorporate effective traffic engineering due to the limited capabilities of the IP technology. In principle, Multiprotocol Label Switching (MPLS), which is a connection-oriented label swapping technology, offers new possibilities in addressing the limitations by allowing the operator to use sophisticated traffic control mechanisms. This paper presents a novel scheme to dynamically manage traffic flows through the network by re-balancing streams during periods of congestion. It proposes management-based algorithms that will allow label switched routers within the network to utilize mechanisms within MPLS to indicate when flows are starting to experience frame/packet loss and then to react accordingly. Based upon knowledge of the customer's Service Level Agreement, together with instantaneous flow information, the label edge routers can then instigate changes to the LSP route and circumvent congestion that would hitherto violate the customer contacts.

  19. Changes of trabecular bone under control of biologically mechanical mechanism (United States)

    Wang, C.; Zhang, C. Q.; Dong, X.; Wu, H.


    In this study, a biological process of bone remodeling was considered as a closed loop feedback control system, which enables bone to optimize and renew itself over a lifetime. A novel idea of combining strain-adaptive and damage-induced remodeling algorithms at Basic Multicellular Unit (BMU) level was introduced. In order to make the outcomes get closer to clinical observation, the stochastic occurrence of microdamage was involved and a hypothesis that remodeling activation probability is related to the value of damage rate was assumed. Integrated with Finite Element Analysis (FEA), the changes of trabecular bone in morphology and material properties were simulated in the course of five years. The results suggest that deterioration and anisotropy of trabecluar bone are inevitable with natural aging, and that compression rather than tension can be applied to strengthen the ability of resistance to fracture. This investigation helps to gain more insight the mechanism of bone loss and identify improved treatment and prevention for osteoporosis or stress fracture.

  20. Acoustic Emission Technique Applied in Textiles Mechanical Characterization

    Directory of Open Access Journals (Sweden)

    Rios-Soberanis Carlos Rolando


    Full Text Available The common textile architecture/geometry are woven, braided, knitted, stitch boded, and Z-pinned. Fibres in textile form exhibit good out-of-plane properties and good fatigue and impact resistance, additionally, they have better dimensional stability and conformability. Besides the nature of the textile, the architecture has a great role in the mechanical behaviour and mechanisms of damage in textiles, therefore damage mechanisms and mechanical performance in structural applications textiles have been a major concern. Mechanical damage occurs to a large extent during the service lifetime consequently it is vital to understand the material mechanical behaviour by identifying its mechanisms of failure such as onset of damage, crack generation and propagation. In this work, textiles of different architecture were used to manufacture epoxy based composites in order to study failure events under tensile load by using acoustic emission technique which is a powerful characterization tool due to its link between AE data and fracture mechanics, which makes this relation a very useful from the engineering point of view.

  1. Mechanism and control of lake eutrophication

    Institute of Scientific and Technical Information of China (English)

    QIN Boqiang; YANG Liuyan; CHEN Feizhou; ZHU Guangwei; ZHANG Lu; CHEN Yiyu


    A review about lake naturally eutrophi- cating, the internal loading of nutrients from lake sediment as well as the mechanism of algal blooms and the control practices was made, especially the eutrophication problem of shallow lakes since sev- enty percent of fresh water lakes in China are shallow lakes. It was found that shallow lakes are apt toward eutrophication than deep lakes. Without any influ- ences of human activity, shallow lakes in the middle and lower reaches of Yangtze River are still easily eutrophicated, which may be owing to the effects of flood in this area. In shallow lakes, sediments are frequently disturbed by wind-wave and resuspended, which result in huge nutrients release to overlying water. This may be the major reason for higher in- ternal loading of nutrients in shallow lakes than in deep lakes. Algal bloom is an extreme response of lake ecosystem to the eutrophication. Appearance of algal blooms is related to physical condition of lakes, such as underwater radiation (or transparency), temperature, and hydrodynamic conditions, or related to geochemical conditions of lakes, like concentra- tions of nutrients and ratio of nitrogen to phosphorus, as well as the physiological advantage of cyanobac- teria such as vacuole for moving towards the radiant energy-rich zone and the mycosporine-like amino acids (MAAs) for resisting the harm of ultraviolet ra- diation. In shallow lakes, these advantages of cyanobacteria are favorable in the competition than in deep lakes. Also being the shallowness, it is more difficult to reduce nutrient loading and to control algae blooms in shallow lakes. For the control of eutrophi- cation, people should follow the sequence from pollution sources control, ecological restoration to catchment management. To control the internal nu- trient release, physical, chemical, biological tech- niques, and even bionic techniques could be selected. The idea of ecological restoration for a eutrophic lake is to shift the ecosystem

  2. Design and Characterization of a Novel Knee Articulation Mechanism (United States)

    Olinski, M.; Gronowicz, A.; Handke, A.; Ceccarelli, M.


    The paper is focused on designing a novel controllable and adjustable mechanism for reproducing human knee joint's complex motion by taking into account the flexion/extension movement in the sagittal plane, in combination with roll and slide. Main requirements for a knee rehabilitation supporting device are specified by researching the knee's anatomy and already existing mechanisms. A three degree of freedom (3 DOF) system (four-bar like linkage with controlled variable lengths of rockers) is synthesised to perform the reference path of instantaneous centre of rotation (ICR). Finally, a preliminary design of the adaptive mechanism is elaborated and a numerical model is built in Adams. Numerical results are derived from simulations that are presented to evaluate the accuracy of the reproduced movement and the mechanism's capabilities.

  3. Control mechanisms for a nonlinear model of international relations

    Energy Technology Data Exchange (ETDEWEB)

    Pentek, A.; Kadtke, J. [Univ. of California, San Diego, La Jolla, CA (United States). Inst. for Pure and Applied Physical Sciences; Lenhart, S. [Univ. of Tennessee, Knoxville, TN (United States). Mathematics Dept.; Protopopescu, V. [Oak Ridge National Lab., TN (United States). Computer Science and Mathematics Div.


    Some issues of control in complex dynamical systems are considered. The authors discuss two control mechanisms, namely: a short range, reactive control based on the chaos control idea and a long-term strategic control based on an optimal control algorithm. They apply these control ideas to simple examples in a discrete nonlinear model of a multi-nation arms race.

  4. Methods for characterization of mechanical and electrical prosthetic vacuum pumps

    Directory of Open Access Journals (Sweden)

    Oluseeni Komolafe, PhD


    Full Text Available Despite increasingly widespread adoption of vacuum-assisted suspension systems in prosthetic clinical practices, there remain gaps in the body of scientific knowledge guiding clinicians’ choices of existing products. In this study, we identified important pump-performance metrics and developed techniques to objectively characterize the evacuation performance of prosthetic vacuum pumps. The sensitivity of the proposed techniques was assessed by characterizing the evacuation performance of two electrical (Harmony e-Pulse [Ottobock; Duderstadt, Germany] and LimbLogic VS [Ohio Willow Wood; Mt. Sterling, Ohio] and three mechanical (Harmony P2, Harmony HD, and Harmony P3 [Ottobock] prosthetic pumps in bench-top testing. Five fixed volume chambers ranging from 33 cm3 (2 in.3 to 197 cm3 (12 in.3 were used to represent different air volume spaces between a prosthetic socket and a liner-clad residual limb. All measurements were obtained at a vacuum gauge pressure of 57.6 kPa (17 inHg. The proposed techniques demonstrated sensitivity to the different electrical and mechanical pumps and, to a lesser degree, to the different setting adjustments of each pump. The sensitivity was less pronounced for the mechanical pumps, and future improvements for testing of mechanical vacuum pumps were proposed. Overall, this study successfully offers techniques feasible as standards for assessing the evacuation performance of prosthetic vacuum pump devices.

  5. Methods for characterization of mechanical and electrical prosthetic vacuum pumps. (United States)

    Komolafe, Oluseeni; Wood, Sean; Caldwell, Ryan; Hansen, Andrew; Fatone, Stefania


    Despite increasingly widespread adoption of vacuum-assisted suspension systems in prosthetic clinical practices, there remain gaps in the body of scientific knowledge guiding clinicians' choices of existing products. In this study, we identified important pump-performance metrics and developed techniques to objectively characterize the evacuation performance of prosthetic vacuum pumps. The sensitivity of the proposed techniques was assessed by characterizing the evacuation performance of two electrical (Harmony e-Pulse [Ottobock; Duderstadt, Germany] and LimbLogic VS [Ohio Willow Wood; Mt. Sterling, Ohio]) and three mechanical (Harmony P2, Harmony HD, and Harmony P3 [Ottobock]) prosthetic pumps in bench-top testing. Five fixed volume chambers ranging from 33 cm(3) (2 in.(3)) to 197 cm(3) (12 in.(3)) were used to represent different air volume spaces between a prosthetic socket and a liner-clad residual limb. All measurements were obtained at a vacuum gauge pressure of 57.6 kPa (17 inHg). The proposed techniques demonstrated sensitivity to the different electrical and mechanical pumps and, to a lesser degree, to the different setting adjustments of each pump. The sensitivity was less pronounced for the mechanical pumps, and future improvements for testing of mechanical vacuum pumps were proposed. Overall, this study successfully offers techniques feasible as standards for assessing the evacuation performance of prosthetic vacuum pump devices.

  6. Cellular Mechanisms of Ciliary Length Control

    Directory of Open Access Journals (Sweden)

    Jacob Keeling


    Full Text Available Cilia and flagella are evolutionarily conserved, membrane-bound, microtubule-based organelles on the surface of most eukaryotic cells. They play important roles in coordinating a variety of signaling pathways during growth, development, cell mobility, and tissue homeostasis. Defects in ciliary structure or function are associated with multiple human disorders called ciliopathies. These diseases affect diverse tissues, including, but not limited to the eyes, kidneys, brain, and lungs. Many processes must be coordinated simultaneously in order to initiate ciliogenesis. These include cell cycle, vesicular trafficking, and axonemal extension. Centrioles play a central role in both cell cycle progression and ciliogenesis, making the transition between basal bodies and mitotic spindle organizers integral to both processes. The maturation of centrioles involves a functional shift from cell division toward cilium nucleation which takes place concurrently with its migration and fusion to the plasma membrane. Several proteinaceous structures of the distal appendages in mother centrioles are required for this docking process. Ciliary assembly and maintenance requires a precise balance between two indispensable processes; so called assembly and disassembly. The interplay between them determines the length of the resulting cilia. These processes require a highly conserved transport system to provide the necessary substances at the tips of the cilia and to recycle ciliary turnover products to the base using a based microtubule intraflagellar transport (IFT system. In this review; we discuss the stages of ciliogenesis as well as mechanisms controlling the lengths of assembled cilia.

  7. Sensitivity analysis of GSI based mechanical characterization of rock mass

    CERN Document Server

    Ván, P


    Recently, the rock mechanical and rock engineering designs and calculations are frequently based on Geological Strength Index (GSI) method, because it is the only system that provides a complete set of mechanical properties for design purpose. Both the failure criteria and the deformation moduli of the rock mass can be calculated with GSI based equations, which consists of the disturbance factor, as well. The aim of this paper is the sensitivity analysis of GSI and disturbance factor dependent equations that characterize the mechanical properties of rock masses. The survey of the GSI system is not our purpose. The results show that the rock mass strength calculated by the Hoek-Brown failure criteria and both the Hoek-Diederichs and modified Hoek-Diederichs deformation moduli are highly sensitive to changes of both the GSI and the D factor, hence their exact determination is important for the rock engineering design.

  8. Characterizing time-dependent mechanics in metallic MEMS

    Directory of Open Access Journals (Sweden)

    Geers M.G.D.


    Full Text Available Experiments for characterization of time-dependent material properties in free-standing metallic microelectromechanical system (MEMS pose challenges: e.g. fabrication and handling (sub-μm sized specimens, control and measurement of sub-μN loads and sub-μm displacements over long periods and various temperatures [1]. A variety of experimental setups have been reported each having their pros and cons. One example is a micro-tensile tester with an ingenious electro-static specimen gripping system [2] aiding simple specimen design giving good results at μN and sub-μm levels, but without in-situ full-field observations. Other progressive examples assimilate the specimen, MEMS actuators and load cells on a single chip [3,4] yielding significant results at nN and nm levels with in-situ TEM/SEM observability, though not without complications: complex load actuator/sensor calibration per chip, measures to reduce fabrication failure and unfeasible cofabrication on wafers with commercial metallic MEMS. This work aims to overcome these drawbacks by developing experimental methods with high sensitivity, precision and in-situ full-field observation capabilities. Moreover, these should be applicable to simple free-standing metallic MEMS that can be co-fabricated with commercial devices. These methods will then serve in systematic studies into size-effects in time-dependent material properties. First a numeric-experimental method is developed. It characterizes bending deformation of onwafer μm-sized aluminum cantilevers. A specially designed micro-clamp is used to mechanically apply a constant precise deflection of the beam (zres <50 nm for a prolonged period, see fig. 1. After this period, the deflection by the micro-clamp is removed. Full-field height maps with the ensuing deformation are measured over time with confocal optical profilometry (COP. This yields the tip deflection as function of time with ~3 nm precision, see fig.2. To extract material

  9. Mechanical control of mitotic progression in single animal cells. (United States)

    Cattin, Cedric J; Düggelin, Marcel; Martinez-Martin, David; Gerber, Christoph; Müller, Daniel J; Stewart, Martin P


    Despite the importance of mitotic cell rounding in tissue development and cell proliferation, there remains a paucity of approaches to investigate the mechanical robustness of cell rounding. Here we introduce ion beam-sculpted microcantilevers that enable precise force-feedback-controlled confinement of single cells while characterizing their progression through mitosis. We identify three force regimes according to the cell response: small forces (∼5 nN) that accelerate mitotic progression, intermediate forces where cells resist confinement (50-100 nN), and yield forces (>100 nN) where a significant decline in cell height impinges on microtubule spindle function, thereby inhibiting mitotic progression. Yield forces are coincident with a nonlinear drop in cell height potentiated by persistent blebbing and loss of cortical F-actin homogeneity. Our results suggest that a buildup of actomyosin-dependent cortical tension and intracellular pressure precedes mechanical failure, or herniation, of the cell cortex at the yield force. Thus, we reveal how the mechanical properties of mitotic cells and their response to external forces are linked to mitotic progression under conditions of mechanical confinement.

  10. Adaptive mechanically controlled lubrication mechanism found in articular joints. (United States)

    Greene, George W; Banquy, Xavier; Lee, Dong Woog; Lowrey, Daniel D; Yu, Jing; Israelachvili, Jacob N


    Articular cartilage is a highly efficacious water-based tribological system that is optimized to provide low friction and wear protection at both low and high loads (pressures) and sliding velocities that must last over a lifetime. Although many different lubrication mechanisms have been proposed, it is becoming increasingly apparent that the tribological performance of cartilage cannot be attributed to a single mechanism acting alone but on the synergistic action of multiple "modes" of lubrication that are adapted to provide optimum lubrication as the normal loads, shear stresses, and rates change. Hyaluronic acid (HA) is abundant in cartilage and synovial fluid and widely thought to play a principal role in joint lubrication although this role remains unclear. HA is also known to complex readily with the glycoprotein lubricin (LUB) to form a cross-linked network that has also been shown to be critical to the wear prevention mechanism of joints. Friction experiments on porcine cartilage using the surface forces apparatus, and enzymatic digestion, reveal an "adaptive" role for an HA-LUB complex whereby, under compression, nominally free HA diffusing out of the cartilage becomes mechanically, i.e., physically, trapped at the interface by the increasingly constricted collagen pore network. The mechanically trapped HA-LUB complex now acts as an effective (chemically bound) "boundary lubricant"--reducing the friction force slightly but, more importantly, eliminating wear damage to the rubbing/shearing surfaces. This paper focuses on the contribution of HA in cartilage lubrication; however, the system as a whole requires both HA and LUB to function optimally under all conditions.

  11. 21 CFR 58.105 - Test and control article characterization. (United States)


    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Test and control article characterization. 58.105 Section 58.105 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Test and control article characterization. (a) The identity, strength, purity, and composition or...

  12. Fabrication and Mechanical Characterization of Hydrogel Infused Network Silk Scaffolds (United States)

    Kundanati, Lakshminath; Singh, Saket K.; Mandal, Biman B.; Murthy, Tejas G.; Gundiah, Namrata; Pugno, Nicola M.


    Development and characterization of porous scaffolds for tissue engineering and regenerative medicine is of great importance. In recent times, silk scaffolds were developed and successfully tested in tissue engineering and drug release applications. We developed a novel composite scaffold by mechanical infusion of silk hydrogel matrix into a highly porous network silk scaffold. The mechanical behaviour of these scaffolds was thoroughly examined for their possible use in load bearing applications. Firstly, unconfined compression experiments show that the denser composite scaffolds displayed significant enhancement in the elastic modulus as compared to either of the components. This effect was examined and further explained with the help of foam mechanics principles. Secondly, results from confined compression experiments that resemble loading of cartilage in confinement, showed nonlinear material responses for all scaffolds. Finally, the confined creep experiments were performed to calculate the hydraulic permeability of the scaffolds using soil mechanics principles. Our results show that composite scaffolds with some modifications can be a potential candidate for use of cartilage like applications. We hope such approaches help in developing novel scaffolds for tissue engineering by providing an understanding of the mechanics and can further be used to develop graded scaffolds by targeted infusion in specific regions. PMID:27681725

  13. Synthesis, Characterization and Thermal Decomposition Mechanism of Cetyltrimethyl Ammonium Tetrathiotungstate

    Institute of Scientific and Technical Information of China (English)

    Gaojun An; Yunqi Liu; Yongming Chai; Hongyan Shang; Chenguang Liu


    The synthesis, characterization and thermal decomposition mechanism of cetyltrimethyl ammonium tetrathiotungstate (CTriMATT) were studied herein. The as-synthesized CTriMATT was characterized by Elemental analysis, X-ray diffraction (XRD), Fourier transform infrared (FT-IR), Ultraviolet visible (UV-Vis) spectra. The results showed that the as-synthesized CTriMATT had high purity and good crystallinity. The introduction of alkyl groups induced a shift of the stretching vibration band of W-S bond to lower wavenumber, while it had no influence on the position of WS2-4. Thermogravimetric analysis (TG), differential thermal analysis (DTA) and in situ XRD characterizations revealed that CTriMATT began to decompose at 423 K in nitrogen and was converted to WS2 eventually. In addition,the decomposition product of CTriMATT at 673 K in nitrogen was characterized by N2 adsorption (BET)and scanning electron microscopy (SEM). The results demonstrated that WS2 with higher specific surface area, and pore volume could be obtained from the thermal decomposition of CTriMATT in nitrogen.

  14. Chemo-mechanical control of neural stem cell differentiation (United States)

    Geishecker, Emily R.

    Cellular processes such as adhesion, proliferation, and differentiation are controlled in part by cell interactions with the microenvironment. Cells can sense and respond to a variety of stimuli, including soluble and insoluble factors (such as proteins and small molecules) and externally applied mechanical stresses. Mechanical properties of the environment, such as substrate stiffness, have also been suggested to play an important role in cell processes. The roles of both biochemical and mechanical signaling in fate modification of stem cells have been explored independently. However, very few studies have been performed to study well-controlled chemo-mechanotransduction. The objective of this work is to design, synthesize, and characterize a chemo-mechanical substrate to encourage neuronal differentiation of C17.2 neural stem cells. In Chapter 2, Polyacrylamide (PA) gels of varying stiffnesses are functionalized with differing amounts of whole collagen to investigate the role of protein concentration in combination with substrate stiffness. As expected, neurons on the softest substrate were more in number and neuronal morphology than those on stiffer substrates. Neurons appeared locally aligned with an expansive network of neurites. Additional experiments would allow for statistical analysis to determine if and how collagen density impacts C17.2 differentiation in combination with substrate stiffness. Due to difficulties associated with whole protein approaches, a similar platform was developed using mixed adhesive peptides, derived from fibronectin and laminin, and is presented in Chapter 3. The matrix elasticity and peptide concentration can be individually modulated to systematically probe the effects of chemo-mechanical signaling on differentiation of C17.2 cells. Polyacrylamide gel stiffness was confirmed using rheological techniques and found to support values published by Yeung et al. [1]. Cellular growth and differentiation were assessed by cell counts

  15. Control Mechanism and Security Region for Intentional Islanding Transition

    DEFF Research Database (Denmark)

    Chen, Yu; Xu, Zhao; Østergaard, Jacob


    in the grid. The concept of Islanding Security Region (ISR) has been proposed as an organic composition of the developed control mechanism. The purpose of this control mechanism is to maintain the frequency stability and eventually the security of power supply to the customers, by utilizing resources from...... generation and demand sides. The control mechanism can be extended to consider the distributed generations like wind power and other innovative technologies such as the Demand as Frequency controlled Reserve (DFR) technique in the future....

  16. Characterization of shape memory alloys for safety mechanisms.

    Energy Technology Data Exchange (ETDEWEB)

    McLaughlin, Jarred T.; Buchheit, Thomas Edward; Massad, Jordan Elias


    Shape memory alloys (SMAs) are metals that exhibit large recoverable strains and exert large forces with tremendous energy densities. The behavior of SMAs is thermomechanically coupled. Their response to temperature is sensitive to their loading condition and their response to loading is sensitive to their thermal condition. This coupled behavior is not to be circumvented, but to be confronted and understood, since it is what manifests SMA's superior clamping performance. To reasonably characterize the coupled behavior of SMA clamping rings used in safety mechanisms, we conduct a series of experiments on SMA samples. The results of the tests will allow increased fidelity in modeling and failure analysis of parts.

  17. Mechanical characterization of carbon nanomembranes from self-assembled monolayers

    Directory of Open Access Journals (Sweden)

    Xianghui Zhang


    Full Text Available This paper reports on the mechanical characterization of carbon nanomembranes (CNMs with a thickness of 1 nm that are fabricated by electron-induced crosslinking of aromatic self-assembled monolayers (SAMs. A novel type of in situ bulge test employing an atomic force microscope (AFM is utilized to investigate their mechanical properties. A series of biphenyl-based molecules with different types of terminal and/or anchor groups were used to prepare the CNMs, such as 4'-[(3-trimethoxysilylpropoxy]-[1,1'-biphenyl]-4-carbonitrile (CBPS, 1,1'-biphenyl-4-thiol (BPT and 4-nitro-1,1'-biphenyl-4-thiol (NBPT. The elastic properties, viscoelastic behaviors and ultimate tensile strength of these biphenyl-based CNMs are investigated and discussed.

  18. Mechanism of controlled release kinetics from medical devices

    Directory of Open Access Journals (Sweden)

    A. Raval


    Full Text Available Utilization of biodegradable polymers for controlled drug delivery has gained immense attention in the pharmaceutical and medical device industry to administer various drugs, proteins and other bio-molecules both systematically and locally to cure several diseases. The efficacy and toxicity of this local therapeutics depends upon drug release kinetics, which will further decide drug deposition, distribution, and retention at the target site. Drug Eluting Stent (DES presently possesses clinical importance as an alternative to Coronary Artery Bypass Grafting due to the ease of the procedure and comparable safety and efficacy. Many models have been developed to describe the drug delivery from polymeric carriers based on the different mechanisms which control the release phenomenon from DES. Advanced characterization techniques facilitate an understanding of the complexities behind design and related drug release behavior of drug eluting stents, which aids in the development of improved future drug eluting systems. This review discusses different drug release mechanisms, engineering principles, mathematical models and current trends that are proposed for drug-polymer coated medical devices such as cardiovascular stents and different analytical methods currently utilized to probe diverse characteristics of drug eluting devices.

  19. Controlled Unusual Stiffness of Mechanical Metamaterials. (United States)

    Lee, Wooju; Kang, Da-Young; Song, Jihwan; Moon, Jun Hyuk; Kim, Dongchoul


    Mechanical metamaterials that are engineered with sub-unit structures present unusual mechanical properties depending on the loading direction. Although they show promise, their practical utility has so far been somewhat limited because, to the best of our knowledge, no study about the potential of mechanical metamaterials made from sophisticatedly tailored sub-unit structures has been made. Here, we present a mechanical metamaterial whose mechanical properties can be systematically designed without changing its chemical composition or weight. We study the mechanical properties of triply periodic bicontinuous structures whose detailed sub-unit structure can be precisely fabricated using various sub-micron fabrication methods. Simulation results show that the effective wave velocity of the structures along with different directions can be designed to introduce the anisotropy of stiffness by changing a volume fraction and aspect ratio. The ratio of Young's modulus to shear modulus can be increased by up to at least 100, which is a 3500% increase over that of isotropic material (2.8, acrylonitrile butadiene styrene). Furthermore, Poisson's ratio of the constituent material changes the ratio while Young's modulus does not influence it. This study presents the promising potential of mechanical metamaterials for versatile industrial and biomedical applications.

  20. Finite-time Control of One-link Mechanical System (United States)

    Matoba, Shunsuke; Nakamura, Nami; Nakamura, Hisakazu; Akiba, Hideyuki

    This paper considers finite-time position control of an one-link mechanical system. The system is modeled by discontinuous differential equations. In this paper, we prove that the Nakamura's local homogeneous controller based on a control Lyapunov function is valid to the position control of the robot manipulators, and show the effectiveness of the controller by experiments.

  1. Recent research progress on unstart mechanism, detection and control of hypersonic inlet (United States)

    Chang, Juntao; Li, Nan; Xu, Kejing; Bao, Wen; Yu, Daren


    The present paper aims to provide a summary report on recent research progress about unstart mechanism, detection and control of hypersonic inlet to help the researchers working on hypersonic inlet to further their work. It covers unstart patterns with their mechanisms, monitoring methods for start/unstart classification and detection, characterization methods for unstart margin, and methods for unstart suppression and control. At first, the inner mechanisms of various unstart patterns have been surveyed and classified, which are respectively caused by contraction ratio (CR)/internal contraction ratio (ICR), backpressure, Mach number and heat release. Followed, monitoring methods (one is for start/unstart classification and the other is for unstart detection) have been introduced respectively. Thirdly, three types of techniques for margin characterization of unstart are listed, which are respectively based on backpressure, the location of shock train leading edge and pressure distribution. At last, unstart suppression and control have been discussed, which are based on flow control or feedback control.

  2. Towards a Unified Representation of Mechanisms for Robotic Control Software

    Directory of Open Access Journals (Sweden)

    Antonio Diaz-Calderon


    Full Text Available This article gives an overview of the Mechanism Model paradigm. The mechanism model paradigm provides a framework to modeling mechanisms for robotic control. The emphasis is on the unification of mathematical models of kinematics/dynamics, geometric information and control system parameters for a variety of robotic systems (including serial manipulators, wheeled and legged locomotors, with algorithms that are needed for typical robot control applications.

  3. Characterization of High Temperature Mechanical Properties Using Laser Ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    David Hurley; Stephen Reese; Farhad Farzbod; Rory Kennedy


    Mechanical properties are controlled to a large degree by defect structures such as dislocations and grain boundaries. These microstructural features involve a perturbation of the perfect crystal lattice (i.e. strain fields). Viewed in this context, high frequency strain waves (i.e. ultrasound) provide a natural choice to study microstructure mediated mechanical properties. In this presentation we use laser ultrasound to probe mechanical properties of materials. This approach utilizes lasers to excite and detect ultrasonic waves, and as a consequence has unique advantages over other methods—it is noncontacting, requires no couplant or invasive sample preparation (other than that used in metallurgical analysis), and has the demonstrated capability to probe microstructure on a micron scale. Laser techniques are highly reproducible enabling sophisticated, microstructurally informed data analysis. Since light is being used for generation and detection of the ultrasonic wave, the specimen being examined is not mechanically coupled to the transducer. As a result, laser ultrasound can be carried out remotely, an especially attractive characteristic for in situ measurements in severe environments. Several examples involving laser ultrasound to measure mechanical properties in high temperature environments will be presented. Emphasis will be place on understanding the role of grain microstructure.

  4. Biochemical and mechanical characterization of Nereis worm jaws (United States)

    Broomell, Christopher C.

    The ultimate goal of biomimetics is to elucidate the design principles governing performance in biological materials and apply them to engineering systems. Successful transfer of these principles will require a thorough understanding of the complex interplay between molecular composition, organization and mechanical properties of the material. This dissertation describes the mechanical and biochemical characterization of jaws from the marine polychaete Nereis virens. Nereid jaws possess remarkable mechanical properties considering their predominantly organic composition. Hardness and stiffness are comparable to human dentin. However, in stark contrast to dentin, in Nereis these properties are achieved without mineralization. The role of metal ions in jaw sclerotization is addressed. In the pristine state, Zn ions are concentrated at the tip and toothed-edge of the jaw and are critical for hardness and modulus; both properties are reduced by ˜70% following Zn removal by treatment with EDTA. Furthermore, metal content in the jaw can be manipulated by soaking Zn-depleted samples in metal solutions; the comparative effects of treatment with alternative transition metals under both dry and hydrated conditions are described. The molecular composition of the jaw is also addressed. Protein comprises ˜90% of the jaw mass; amino acid analysis indicates that histidine is increased in the hardened, Zn-rich tip. The major protein component in Nereid jaw extracts is purified and characterized by partial peptide mapping and isolation of a partial clone from a jaw pulp cDNA library. Nvjp-1 is a 38 kDa glycine- histidine-rich protein and is believed to be the principle structural protein in the hardened jaw tip. The effects of selected environmental factors on Nvjp-1 structure and assembly are described. Transition from low to high pH is accompanied by changes in secondary structure and a significant molecular elongation. Furthermore, exposure to transition metals, notably Zn and

  5. Characterization and control of surfactant-mediated Norovirus interactions. (United States)

    Mertens, Brittany S; Velev, Orlin D


    Understanding of the colloidal interactions of Norovirus particles in aqueous medium could provide insights on the origins of the notorious stability and infectivity of these widespread viral agents. We characterized the effects of solution pH and surfactant type and concentration on the aggregation, dispersion, and disassembly of Norovirus virus-like particles (VLPs) using dynamic light scattering, electrophoretic light scattering, and transmission electron microscopy. Owing to net negative surface charge of the VLPs at neutral pH, low concentrations of cationic surfactant tend to aggregate the VLPs, whereas low concentrations of anionic surfactant tend to disperse the particles. Increasing the concentration of these surfactants beyond their critical micelle concentration leads to virus capsid disassembly and breakdown of aggregates. Non-ionic surfactants, however, had little effect on virus interactions and likely stabilized them additionally in suspension. The data were interpreted on the basis of simple models for surfactant binding and re-charging of the virus capsid. We used zeta potential data to characterize virus surface charge and interpret the mechanisms behind these demonstrated surfactant-virus interactions. The fundamental understanding and control of these interactions will aid in practical formulations for virus inactivation and removal from contaminated surfaces.

  6. Mechanical Characterization of Molecular Assemblies at Oil/Water Interfaces (United States)

    Yuan, Wa

    The self-assembly of charged molecules in liquid phases and their ability to form functional layers at immiscible interfaces are areas of great interest. However, the implementation of these assemblies is often limited by a lack of understanding of the detailed assembly mechanisms. In order to enhance the performance of interfacial assemblies it is essential to be able to characterize the physical and mechanical properties of assembled layers, as well as develop model systems that will allow us to examine the factors that govern their interaction with the surrounding environment. The key purpose of this thesis is to develop an understanding of some of the important factors influencing interfacial assemblies at immiscible liquid interfaces. The first portion of the work involves mechanical characterization of interfacial layers formed by large amphiphilic molecules. The study of block and gradient copolymers, reveals the effect of copolymer sequence distribution on the ability of these molecules to form interfacial assemblies. Specifically, the unique network structure formed by gradient copolymers at oil/water interfaces enables us to create a robust membrane at the interface by ionic crosslinking. The second part of this thesis explores smaller molecule assemblies at liquid interfaces, including commonly used commercial surfactant (span 80) and nano particles (graphene oxide). Both studies demonstrate an interesting correlation between molecular structure and overall properties of the assembled layers. Factors such as interfacial density, particle sizes and pH can greatly influence the structure of the assembled layers, resulting in interesting phenomena such as spontaneous emulsification, wrinkling and layer collapse. The bulk of the oil/water interface study was performed using axisymmetric drop shape analysis (DSA), which successfully quantifies the mechanical tension in the interfacial layer. This analysis was further extended by a development of a double

  7. Mechanical characterization of hyperelastic polydimethylsiloxane by simple shear test

    Energy Technology Data Exchange (ETDEWEB)

    Nunes, L.C.S., E-mail: [Laboratory of Opto-Mechanics (LOM/LMTA), Department of Mechanical Engineering (PGMEC-TEM), Universidade Federal Fluminense - UFF, Rua Passo da Patria, 156, Bloco E, Sala 216, Niteroi, RJ CEP 24210-240 (Brazil)


    Graphical abstract: Display Omitted Research highlights: {yields} Mechanical characterization of Polydimethylsiloxane under large shear deformations {yields} Non-linear shear stress-strain relationship is achieved in simple shear tests {yields} Constitutive modeling of large shear deformations in rubber-like materials is proposed. - Abstract: Polydimethylsiloxane (PDMS) is a commercially silicone rubber widely used in mechanical sensors, electronic products and medical devices. This paper describes and analyzes the mechanical behavior of polymer PDMS under large shear deformations. The goal of this work is to estimate experimentally the angular distortions associated with different applied forces, considering a simple shear test based on single lap joints. The experimental procedure to obtain the displacement field is carried out using the digital image correlation (DIC) method, which is an optical-numerical experimental approach developed for full-field and non-contact measurements. The material parameters, associated with classical Mooney-Rivlin model, are estimated from experimental data by means of Levenberg-Marquardt method. Furthermore, due to nonlinear stress-strain behavior observed in experimental data, it is proposed a new nonlinear model and two new parameters are determined in the same way.

  8. Cutaneous mechanisms of isometric ankle force control

    DEFF Research Database (Denmark)

    Choi, Julia T; Jensen, Jesper Lundbye; Leukel, Christian


    The sense of force is critical in the control of movement and posture. Multiple factors influence our perception of exerted force, including inputs from cutaneous afferents, muscle afferents and central commands. Here, we studied the influence of cutaneous feedback on the control of ankle force...... of transient stimulation on force error were greater when compared to continuous stimulation and lidocaine injection. Position-matching performance was unaffected by peroneal nerve or plantar nerve stimulation. Our results show that cutaneous feedback plays a role in the control of force output at the ankle...... joint. Understanding how the nervous system normally uses cutaneous feedback in motor control will help us identify which functional aspects are impaired in aging and neurological diseases....

  9. Control Engineering Analysis of Mechanical Pitch Systems (United States)

    Bernicke, Olaf; Gauterin, Eckhard; Schulte, Horst; Zajac, Michal


    With the help of a local stability analysis the coefficient range of a discrete damper, used for centrifugal forced, mechanical pitch system of small wind turbines (SWT), is gained for equilibrium points. - By a global stability analysis the gained coefficient range can be validated. An appropriate approach by Takagi-Sugeno is presented in the paper.

  10. Mechanical biocompatibility of prosthetic meshes: a comprehensive protocol for mechanical characterization. (United States)

    Maurer, M M; Röhrnbauer, B; Feola, A; Deprest, J; Mazza, E


    This study is aimed at a comprehensive and extensive characterization of the mechanical biocompatibility of mesh prostheses. A robust and simple experimental protocol and a set of parameters is proposed, addressing stiffness under uniaxial and biaxial loading conditions, anisotropy, influence of prior deformation history, local mismatch of deformation mechanisms, and changes in mechanical properties when embedded in a homogeneous matrix. These parameters can form the basis for comparison of different mesh types and for evaluation of their mechanical biocompatibility. Measurements were performed on nine mesh types used for hernia and/or pelvic repair, including heavier as well as lighter implants and covering a wide range of mechanical responses. A total of 93 experiments were performed and all parameters are represented for each mesh in a single diagram to facilitate the quantitative assessment of implant characteristics and their comparison. The mechanics of implants is a critical factor determining clinical performance which should be accounted for in mesh selection and for development of future implants.

  11. Physico-mechanical characterization of adobe bricks from Cyprus (United States)

    Ioannou, I.; Illampas, R.; Charmpis, D. C.


    Adobe bricks have been used in the construction of buildings for thousands of years. In our days, adobe masonry is no longer a prevailing form of construction. However, a great number of earthen buildings still survives in most regions of the world and constitutes an essential part of the international architectural and cultural heritage. Furthermore, efforts are currently being made to reintroduce adobes as an environmentally-friendly building material to contemporary architecture within the context of sustainable development. Despite the long-term use of adobes and their importance for the society, our knowledge of many aspects of this material is still rather limited. As a result, there are many ongoing research initiatives worldwide aiming to investigate the physicochemical and mechanical properties of adobe bricks and related durability problems. In this paper, we present our work (which is funded by the Cyprus Research Promotion Foundation Project EΠIXEIPHΣEIΣ/ΠPOION/0609/41, the Republic of Cyprus and the European Regional Development Fund) on the physico-mechanical characterization of adobes from Cyprus. In the absence of standardized procedures for most of the tests carried out, testing methodologies that either refer to other types of masonry materials and/or are encountered in the literature are adopted. The results show that adobes are mostly composed of random quantities of silt and clay. Calcite is also predominant in the X-ray diffraction analyses patterns. The average capillary water absorption coefficient of the test specimens rarely exceeds 1 mm/min1/2 (when measured against a saturated sponge surface), while their thermal conductivity is around 0.55 W/mK. Extensive experimental data on the material's mechanical behaviour show that adobes' response to compression is characterized by intense deformability. The average value of compressive strength depends greatly on the form of specimen examined (cube, cylinder, prism) and the failure criterion

  12. Characterization and modelling of the mechanical properties of mineral wool

    DEFF Research Database (Denmark)

    Chapelle, Lucie


    the comparison of individual characteristics of different mineral wool materials and provide simple descriptors of the 3D structure. All the methods described here are applied to glass wool and stone wool. By developing a FEM model including the real characteristic of the mineral wool fibre structure, the effect......Mineral wool designates a highly porous network of fibres drawn by spinning molten minerals. Traditionally, mineral wool products have found application as thermal and acoustic insulation of buildings. Recent concepts where mineral wool products are subjected to higher structural loads have emerged...... properties of mineral wool relate closely to the arrangement and characteristics of the fibres inside the material. Because of the complex architecture of mineral wool, the characterization and the understanding of the mechanism of deformations require a new methodology. In this PhD thesis, a methodology...

  13. Material, Mechanical, and Tribological Characterization of Laser-Treated Surfaces (United States)

    Yilbas, Bekir Sami; Kumar, Aditya; Bhushan, Bharat; Aleem, B. J. Abdul


    Laser treatment under nitrogen assisting gas environment of cobalt-nickel-chromium-tungsten-based superalloy and high-velocity oxygen-fuel thermal spray coating of nickel-chromium-based superalloy on carbon steel was carried out to improve mechanical and tribological properties. Superalloy surface was preprepared to include B4C particles at the surface prior to the laser treatment process. Material and morphological changes in the laser-treated samples were examined using scanning electron microscopy, energy-dispersive spectroscopy, and x-ray diffraction (XRD) analysis. Residual stresses present at the surface region of the laser-treated layer were determined from the XRD data. The microhardness of the laser-treated surface was measured by indentation tests. Fracture toughness of the coating surfaces before and after laser treatment were also measured using overload indentation tests. Macrowear and macrofriction characterization were carried out using pin-on-disk tests.

  14. [Visual attention and its control mechanisms]. (United States)

    Ogawa, Hirokazu


    Given the vast amount of visual information in visual scenes, the capacity of our brain to processes such scenes is severely limited. The core mechanism of selection is referred to as visual attention, and it has been the topic of intense investigation for over 25 years in experimental psychology and cognitive neuroscience. Visual attention is not a single, unitary mechanism, but consists of multiple subcomponents. Attention can be directed to various aspects of visual information, such as spatial location, features, or objects. Additionally, attention is guided by external factors such as the salience of stimuli, or whether we are able to move our attention volitionally. The purpose of this article is to review the status of these components of attentional guidance and how they interact with each other, with an emphasis on psychophysical studies.

  15. Temperature buffer test. Hydro-mechanical and chemical/ mineralogical characterizations

    Energy Technology Data Exchange (ETDEWEB)

    Aakesson, Mattias; Olsson, Siv; Dueck, Ann; Nilsson, Ulf; Karnland, Ola [Clay Technology AB, Lund (Sweden); Kiviranta, Leena; Kumpulainen, Sirpa [BandTech Oy, Helsinki (Finland); Linden, Johan [Aabo Akademi, Aabo (Finland)


    The Temperature Buffer Test (TBT) is a joint project between SKB/ANDRA and supported by ENRESA (modeling) and DBE (instrumentation), which aims at improving the understanding and to model the thermo-hydro-mechanical behavior of buffers made of swelling clay submitted to high temperatures (over 100 deg C) during the water saturation process. The test has been carried out in a KBS-3 deposition hole at Aspo HRL. It was installed during the spring of 2003. Two steel heaters (3 m long, 0.6 m diameter) and two buffer arrangements have been investigated: the lower heater was surrounded by rings of compacted Wyoming bentonite only, whereas the upper heater was surrounded by a composite barrier, with a sand shield between the heater and the bentonite. The test was dismantled and sampled during the winter of 2009/2010. This report presents the hydro-mechanical and chemical/mineralogical characterization program which was launched subsequent to the dismantling operation. The main goal has been to investigate if any significant differences could be observed between material from the field experiment and the reference material. The field samples were mainly taken from Ring 4 (located at the mid-section around the lower heater), in which the temperature in the innermost part reached 155 deg C. The following hydro-mechanical properties have been determined for the material (test technique within brackets): hydraulic conductivity (swelling pressure device), swelling pressure (swelling pressure device), unconfined compression strength (mechanical press), shear strength (triaxial cell) and retention properties (jar method). The following chemical/mineralogical properties (methods within brackets) were determined: anion analysis of water leachates (IC), chemical composition (ICP/AES+MS, EGA), cation exchange capacity (CEC, Cu-trien method) and exchangeable cations (exchange with NH4, ICPAES), mineralogical composition (XRD and FTIR), element distribution and microstructure (SEM and

  16. High Precision Motion Control of Hybrid Five-Bar Mechanism with an Intelligent Control

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ke; WANG Sheng-ze


    Hybrid mechanism is a new type of planar controllable mechanism. Position control accuracy of system determines the output acctracy of the mechanism In order to achieve the desired high accuracy, nonlinear factors as friction must be accurately compensated in the real-time servo control algarithm. In this paper, the model of a hybrid flve-bar mechanism is introduced In terms of the characteristics of the hybrid mechanism, a hybrid intelligent control algorithm based on proportional-integral-derivative(PID) control and cerebellar model articulation control techniques was presented and used to perform control of hybrid five-bar mechanism for the first time. The simulation results show that the hybrid control method can improve the control effect remarkably, compared with the traditional PID control strategy.

  17. Cutaneous mechanisms of isometric ankle force control. (United States)

    Choi, Julia T; Lundbye-Jensen, Jesper; Leukel, Christian; Nielsen, Jens Bo


    The sense of force is critical in the control of movement and posture. Multiple factors influence our perception of exerted force, including inputs from cutaneous afferents, muscle afferents and central commands. Here, we studied the influence of cutaneous feedback on the control of ankle force output. We used repetitive electrical stimulation of the superficial peroneal (foot dorsum) and medial plantar nerves (foot sole) to disrupt cutaneous afferent input in 8 healthy subjects. We measured the effects of repetitive nerve stimulation on (1) tactile thresholds, (2) performance in an ankle force-matching and (3) an ankle position-matching task. Additional force-matching experiments were done to compare the effects of transient versus continuous stimulation in 6 subjects and to determine the effects of foot anesthesia using lidocaine in another 6 subjects. The results showed that stimulation decreased cutaneous sensory function as evidenced by increased touch threshold. Absolute dorsiflexion force error increased without visual feedback during peroneal nerve stimulation. This was not a general effect of stimulation because force error did not increase during plantar nerve stimulation. The effects of transient stimulation on force error were greater when compared to continuous stimulation and lidocaine injection. Position-matching performance was unaffected by peroneal nerve or plantar nerve stimulation. Our results show that cutaneous feedback plays a role in the control of force output at the ankle joint. Understanding how the nervous system normally uses cutaneous feedback in motor control will help us identify which functional aspects are impaired in aging and neurological diseases.

  18. Improving Control Mechanism at Routers in TCP/IP Network

    Directory of Open Access Journals (Sweden)

    Nguyen Kim Quoc


    Full Text Available The existing control mechanisms at the network nodes have a good active and very effective at each local router, but they do not still strong enough to control nonlinear and dynamical behaviour of the network. Therefore, the control system requirements must be designed to be flexible to fully grasp the important status information of the variation and intelligent control methods to control network congestion in nonlinear network. To solve this problem, we propose a solution combined fuzzy reasoning with neural network control put on active queue management mechanisms at the network nodes.

  19. Fabrication and characterization of fluoridated hydroxyapatite nanopowders via mechanical alloying

    Energy Technology Data Exchange (ETDEWEB)

    Fathi, M.H. [Department of Materials Engineering, Isfahan University of Technology, Isfahan, 8415683111 (Iran, Islamic Republic of); Zahrani, E. Mohammadi [Department of Materials Engineering, Isfahan University of Technology, Isfahan, 8415683111 (Iran, Islamic Republic of)], E-mail:


    The aim of this work was preparation and characterization of fluoridated hydroxyapatite (FHA) nanopowders with different degrees of fluoridation via mechanical alloying (MA) method. FHA nanopowders with a chemical composition of Ca{sub 10}(PO{sub 4}){sub 6}OH{sub 2-x}F{sub x} (where x values were selected equal to 0.0, 0.5, 1.0, 1.5, and 2.0) were synthesized using a mixture of appropriate amounts of calcium hydroxide, phosphorous pentoxide, and calcium fluoride powders by 6 h of mechanical alloying at 300 rpm, using eight balls with a diameter of 20 mm, and the ball-to-powder weight ratio equal to 35:1. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and ICP-OES analysis techniques were utilized in order to evaluate phase composition, agglomerates size distribution, morphology and particle size, functional groups, and purity of synthesized FHA nanopowders. The FTIR result combined with the X-ray diffraction indicated that single phase of homogeneous FHA with the carbonate peaks in the FTIR spectrum could be prepared after 6 h MA. TEM photomicrograph revealed that obtained powder after 6 h of MA was composed of FHA nanoparticles (35-65 nm). The results of ICP-OES analysis illustrated that synthesized nanopowder could fulfill the requirement of ASTM F1185-88 to be used as a biomaterial.

  20. Mechanical characterization of cellulosic thecal plates in dinoflagellates by nanoindentation. (United States)

    Lau, Ringo K L; Kwok, Alvin C M; Chan, W K; Zhang, T Y; Wong, Joseph T Y


    Dinoflagellates constitute an important group of microorganisms. Symbiotic dinoflagellates are responsible for the primary production of coral reef ecosystems and the phenomenon of their demise is known as "coral bleaching." Blooming of the planktonic dinoflagellates is the major cause of "red tides." Many dinoflagellates have prominent membrane-bound thecal plates at their cell cortices. These thecal plates have high cellulose content and are biologically fabricated into various shapes. However, the mechanical properties of theca have not previously been characterized; understanding these properties, including hardness and elastic modulus, will give insights into the ecological significance and biotechnological potential of bio-fabricated structures. A series of nanoindentation tests were performed on various locations of cellulosic thecal plates isolated from the dinoflagellates Alexandrium catenella and Lingulodinium polyedrum. Despite having transparent properties, thecal plates possess mechanical properties comparable to softwood cell walls, implicating their role as a protective cell covering. Consistent measurements were obtained when indentation was performed at various locations, which contrasts with the high variability of cellulose microfibers from plant sources. The present study demonstrated the novel properties of this potential new source of cellulose.

  1. Quality control mechanisms of protein biogenesis: proteostasis dies hard

    Directory of Open Access Journals (Sweden)

    Timothy Jan Bergmann


    Full Text Available The biosynthesis of proteins entails a complex series of chemical reactions that transform the information stored in the nucleic acid sequence into a polypeptide chain that needs to properly fold and reach its functional location in or outside the cell. It is of no surprise that errors might occur that alter the polypeptide sequence leading to a non-functional proteins or that impede delivery of proteins at the appropriate site of activity. In order to minimize such mistakes and guarantee the synthesis of the correct amount and quality of the proteome, cells have developed folding, quality control, degradation and transport mechanisms that ensure and tightly regulate protein biogenesis. Genetic mutations, harsh environmental conditions or attack by pathogens can subvert the cellular quality control machineries and perturb cellular proteostasis leading to pathological conditions. This review summarizes basic concepts of the flow of information from DNA to folded and active proteins and to the variable fidelity (from incredibly high to quite sloppy characterizing these processes. We will give particular emphasis on events that maintain or recover the homeostasis of the endoplasmic reticulum (ER, a major site of proteins synthesis and folding in eukaryotic cells. Finally, we will report on how cells can adapt to stressful conditions, how perturbation of ER homeostasis may result in diseases and how these can be treated.

  2. Generating and characterizing the mechanical properties of cell-derived matrices using atomic force microscopy. (United States)

    Tello, Marta; Spenlé, Caroline; Hemmerlé, Joseph; Mercier, Luc; Fabre, Roxane; Allio, Guillaume; Simon-Assmann, Patricia; Goetz, Jacky G


    Mechanical interaction between cells and their surrounding extracellular matrix (ECM) controls key processes such as proliferation, differentiation and motility. For many years, two-dimensional (2D) models were used to better understand the interactions between cells and their surrounding ECM. More recently, variation of the mechanical properties of tissues has been reported to play a major role in physiological and pathological scenarios such as cancer progression. The 3D architecture of the ECM finely tunes cellular behavior to perform physiologically relevant tasks. Technical limitations prevented scientists from obtaining accurate assessment of the mechanical properties of physiologically realistic matrices. There is therefore a need for combining the production of high-quality cell-derived 3D matrices (CDMs) and the characterization of their topographical and mechanical properties. Here, we describe methods that allow to accurately measure the young modulus of matrices produced by various cellular types. In the first part, we will describe and review several protocols for generating CDMs matrices from endothelial, epithelial, fibroblastic, muscle and mesenchymal stem cells. We will discuss tools allowing the characterization of the topographical details as well as of the protein content of such CDMs. In a second part, we will report the methodologies that can be used, based on atomic force microscopy, to accurately evaluate the stiffness properties of the CDMs through the quantification of their young modulus. Altogether, such methodologies allow characterizing the stiffness and topography of matrices deposited by the cells, which is key for the understanding of cellular behavior in physiological conditions.

  3. Enzymatic characterization of insecticide resistance mechanisms in field populations of Malaysian Culex quinquefasciatus say (Diptera: Culicidae.

    Directory of Open Access Journals (Sweden)

    Van Lun Low

    Full Text Available BACKGROUND: There has been no comprehensive study on biochemical characterization of insecticide resistance mechanisms in field populations of Malaysian Culex quinquefasciatus. To fill this void in the literature, a nationwide investigation was performed to quantify the enzyme activities, thereby attempting to characterize the potential resistance mechanisms in Cx. quinquefasciatus in residential areas in Malaysia. METHODOLOGY/PRINCIPAL FINDINGS: Culex quinquefasciatus from 14 residential areas across 13 states and one federal territory were subjected to esterases, mixed function oxidases, glutathione-S-transferase and insensitive acetylcholinesterase assays. Enzyme assays revealed that α-esterases and β-esterases were elevated in 13 populations and 12 populations, respectively. Nine populations demonstrated elevated levels of mixed function oxidases and glutathione-S-transferase. Acetylcholinesterase was insensitive to propoxur in all 14 populations. Activity of α-esterases associated with malathion resistance was found in the present study. In addition, an association between the activity of α-esterases and β-esterases was also demonstrated. CONCLUSIONS/SIGNIFICANCE: The present study has characterized the potential biochemical mechanisms in contributing towards insecticide resistance in Cx. quinquefasciatus field populations in Malaysia. Identification of mechanisms underlying the insecticide resistance will be beneficial in developing effective mosquito control programs in Malaysia.

  4. Novel Mechanism Control Algorithm for Wired Network

    Directory of Open Access Journals (Sweden)

    V. B. Kirubanand


    Full Text Available Problem statement: A critical issue in wireless network where the data can hack by the person and we add a novel encryption mechanism to protect the data transfer from client to server and vice versa. Approach: We present a queuing model of a client and server that uses for bulk arrival service. The arrival of data requests is assumed to Markov Poisson Distributed Process (MPDP and the events are considered in the server for process sharing. We obtained the parameter of service rate, arrival rate, expected waiting time and expected busy period. We also derive the expression for the data value of threshold. Results: The total number of packets request processed, there was no time limit to arrivals, while compared to m/m/1 model. Our model m/m (1,b/1 was more efficient to find response and request time in between client and server. Conclusions: Our proposed simulation model validated through Java programming.

  5. An immunosurveillance mechanism controls cancer cell ploidy. (United States)

    Senovilla, Laura; Vitale, Ilio; Martins, Isabelle; Tailler, Maximilien; Pailleret, Claire; Michaud, Mickaël; Galluzzi, Lorenzo; Adjemian, Sandy; Kepp, Oliver; Niso-Santano, Mireia; Shen, Shensi; Mariño, Guillermo; Criollo, Alfredo; Boilève, Alice; Job, Bastien; Ladoire, Sylvain; Ghiringhelli, François; Sistigu, Antonella; Yamazaki, Takahiro; Rello-Varona, Santiago; Locher, Clara; Poirier-Colame, Vichnou; Talbot, Monique; Valent, Alexander; Berardinelli, Francesco; Antoccia, Antonio; Ciccosanti, Fabiola; Fimia, Gian Maria; Piacentini, Mauro; Fueyo, Antonio; Messina, Nicole L; Li, Ming; Chan, Christopher J; Sigl, Verena; Pourcher, Guillaume; Ruckenstuhl, Christoph; Carmona-Gutierrez, Didac; Lazar, Vladimir; Penninger, Josef M; Madeo, Frank; López-Otín, Carlos; Smyth, Mark J; Zitvogel, Laurence; Castedo, Maria; Kroemer, Guido


    Cancer cells accommodate multiple genetic and epigenetic alterations that initially activate intrinsic (cell-autonomous) and extrinsic (immune-mediated) oncosuppressive mechanisms. Only once these barriers to oncogenesis have been overcome can malignant growth proceed unrestrained. Tetraploidization can contribute to oncogenesis because hyperploid cells are genomically unstable. We report that hyperploid cancer cells become immunogenic because of a constitutive endoplasmic reticulum stress response resulting in the aberrant cell surface exposure of calreticulin. Hyperploid, calreticulin-exposing cancer cells readily proliferated in immunodeficient mice and conserved their increased DNA content. In contrast, hyperploid cells injected into immunocompetent mice generated tumors only after a delay, and such tumors exhibited reduced DNA content, endoplasmic reticulum stress, and calreticulin exposure. Our results unveil an immunosurveillance system that imposes immunoselection against hyperploidy in carcinogen- and oncogene-induced cancers.

  6. Control of a mechanical gripper with a fuzzy controller; Control de una garra robotizada mediante un controlador borroso

    Energy Technology Data Exchange (ETDEWEB)

    Alberdi, J.; Barcala, J.M.; Gamero, E.; Navarrete, J.J.


    A fuzzy logic system is used to control a mechanical gripper. System is based in a NLX230 fuzzy micro controller. Control rules are programmed by a 68020 microprocessor in the micro controller memory. Stress and its derived are used as feedback signals in the control. This system can adapt its effort to the mechanical resistance of the object between the fingers. (Author)

  7. Control of a mechanical gripper with a fuzzy controller; Control de una garra robotizada mediante un controlador borroso

    Energy Technology Data Exchange (ETDEWEB)

    Alberdi, J.; Barcala, J.M.; Gamero, E.; Navarrete, J.J.


    A fuzzy logic system is used to control a mechanical gripper. System is based in a NLX230 fuzzy micro controller. Control rules are programmed by a 68020 microprocessor in the micro controller memory. Stress and its derived are used as feedback signals in the control. This system can adapt its effort to the mechanical resistance of the object between the fingers.

  8. Urgent epidemic control mechanism for aviation networks

    KAUST Repository

    Peng, Chengbin


    In the current century, the highly developed transportation system can not only boost the economy, but also greatly accelerate the spreading of epidemics. While some epidemic diseases may infect quite a number of people ahead of our awareness, the health care resources such as vaccines and the medical staff are usually locally or even globally insufficient. In this research, with the network of major aviation routes as an example, we present a method to determine the optimal locations to allocate the medical service in order to minimize the impact of the infectious disease with limited resources. Specifically, we demonstrate that when the medical resources are insufficient, we should concentrate our efforts on the travelers with the objective of effectively controlling the spreading rate of the epidemic diseases. © 2011 Springer-Verlag Berlin Heidelberg.

  9. Mechanical design and control of a new myoelectric hand prosthesis

    NARCIS (Netherlands)

    Peerdeman, B.; Stramigioli, S.; Hekman, E.; Brouwer, D.M.; Misra, S.


    The development of modern, myoelectrically controlled hand prostheses can be difficult, due to the many requirements its mechanical design and control system need to fulfill [1]. The hand should be controllable with few input signals, while being able to perform a wide range of motions. It should be

  10. Chemical and mechanical weed control in soybean (Glycine max

    Directory of Open Access Journals (Sweden)

    Weber, Jonas Felix


    Full Text Available In this study we investigated the possibility of chemical and mechanical weed control strategies in soybean. Soybean field experiments were carried out in 2013 and 2014 in Southern Germany. Five treatments including common herbicide mixtures and four mechanical weed control treatments, implementing a harrow and a hoe, were tested at different locations. In the herbicide experiments two treatments were applied by PRE emergence herbicides (metribuzin, clomazone, dimethenamid and metribuzin, flufenacet, clomazone and another two treatments were sprayed with a combination of PRE + POST emergence herbicides (metribuzin, flufenacet, thifensulfuron and pendimethalin, thifensulfuron, bentazone, cycloxydim. Furthermore, a POST herbicide treatment was implemented (thifensulfuron, bentazone, thifensulfuron and fluazifop-P-butyl. In the mechanical weed control experiments, treatments were: three times hoeing, PRE emergence harrowing plus three times hoeing, hoeing and harrowing in rotation or three times harrowing. In both experiments an untreated control was included. A 90% weed control efficacy and 23% yield increase was observed in the POST herbicide treatment. PRE + POST treatments resulted in 92% to 99% weed control efficiency and 15% yield increase compared to the untreated control. In the mechanical weed control experiments the combination of PRE emergence harrowing and POST emergence hoeing resulted in 82% weed control efficiency and 34% higher yield compared to the untreated control. Less weed control efficiency (72% was observed in the harrow treatment, leading to 20% higher yield compared to the control. The suitability of both strategies for implementation in “Integrated Weed Management” has been investigated.

  11. Fuzzy control of electro-mechanical gearbox actuator

    Institute of Scientific and Technical Information of China (English)

    G Iordanidis; P H Mellor; D Holliday; P M Churn


    In this paper, a prototype direct-drive electro-mechanical actuator is proposed to select gears in a high performance gearbox. Because of the nonlinear behavior of the actuator, a fuzzy logic controller is adopted. The result of simulation has proved that the dynamic response obtained using the fuzzy controller is much faster than that obtained using traditional PD controller.

  12. Physical damping in IDA-PBC controlled underactuated mechanical systems

    NARCIS (Netherlands)

    Gomez-Estern, F.; Schaft, van der A.J.


    Energy shaping and passivity-based control designs have proven to be effective in solving control problems for tinderactttated mechanical systems. In recent works, interconnection and damping assignment passivity-based control (IDA-PEC) has been successfully applied to open-loop conservative models,

  13. Control on Crystal Forms of Ultrafine Barium Carbonate Particles and Study on its Mechanism

    Institute of Scientific and Technical Information of China (English)


    Barium carbonate particles were prepared by using homogeneous precipitation method and co-precipitation method respectively. Through adding different crystalline controlling modifiers, Barium carbonate particles in five different shapes including linear, needle-like, pillarlike, sphere-like and dumbbell-like were synthesized. These particles were characterized by SEM and XRD, and their synthetic mechanism was discussed in this paper.

  14. Mechanical and electrochemical characterization of vanadium nitride (VN) thin films

    Energy Technology Data Exchange (ETDEWEB)

    Caicedo, J.C., E-mail: [Grupo de Peliculas Delgadas, Departamento de Fisica, Universidad del Valle, Cali (Colombia); Zambrano, G. [Grupo de Peliculas Delgadas, Departamento de Fisica, Universidad del Valle, Cali (Colombia); Aperador, W. [Ingenieria Mecatronica, Universidad Militar Nueva Granada, Bogota (Colombia); Escobar-Alarcon, L.; Camps, E. [Departamento de Fisica, Instituto Nacional de Investigaciones Nucleares, Apdo. Postal 18-1027, Mexico, DF 11801 (Mexico)


    Vanadium nitride (V-N) thin films were grown using a reactive d.c. magnetron sputtering process, from a vanadium target (99.999%) in an Ar/N{sub 2} gas mixture at different deposition bias voltage. Films were deposited onto silicon (1 0 0) and RUS-3 steel substrates at 400 deg. C. Structural, compositional, mechanical and electrochemical characterizations were performed by X-ray diffraction (XRD), elastic forward analysis (EFA), nanoindentation, electrochemical impedance spectroscopy (EIS), and Tafel polarization curves, respectively. X-ray diffraction patterns show the presence of (1 1 1) and (2 0 0) crystallographic orientations associated to the V-N cubic phase. Nanoindentation measurements revealed that when the bias voltage increases from 0 V to -150 V the hardness and elastic modulus are increased from 11 GPa to 20 GPa and from 187 GPa to 221 GPa, respectively. EIS and Tafel curves showed that the corrosion rate of steel, coated with V-N single layer films deposited without bias voltage, diminishes 90% compared to the steel without this coating. On the other hand, when the V-N coating was deposited at the highest d.c. bias voltage (-150 V), the corrosion rate was greater than in the steel coated with zero-voltage (0 V) V-N films. This last result could be attributed to the formation of porosities produced by the ion bombardment during the deposition process.

  15. First resistance mechanisms characterization in glyphosate-resistant Leptochloa virgata.

    Directory of Open Access Journals (Sweden)

    Ricardo Alcántara-de la Cruz


    Full Text Available Leptochloa virgata (L. P. Beauv. is an annual weed common in citrus groves in the states of Puebla and Veracruz, Mexico limiting their production. Since 2010, several L. virgata populations were identified as being resistant to glyphosate, but studies of their resistance mechanisms developed by this species have been conducted. In this work, three glyphosate-resistant populations (R8, R14 and R15 collected in citrus orchards from Mexico, were used to study their resistance mechanisms comparing them to one susceptible population (S. Dose-response and shikimic acid accumulation assays confirmed the glyphosate resistance of the three resistant populations. Higher doses of up to 720 g ae ha-1 (field dose were needed to control by 50% plants of resistant populations. The S population absorbed between 7 and 13% more 14C-glyphosate than resistant ones, and translocated up to 32.2% of 14C-glyphosate to the roots at 96 h after treatment (HAT. The R8, R14 and R15 populations translocated only 24.5, 26.5 and 21.9%, respectively. The enzyme activity of 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS was not different in the S, R8 and R14 populations. The R15 Population exhibited 165.9 times greater EPSPS activity. Additionally, this population showed a higher EPSPS basal activity and a substitution in the codon 106 from Proline to Serine in the EPSPS protein sequence. EPSPS gene expression in the R15 population was similar to that of S population. In conclusion, the three resistant L. virgata populations show reduced absorption and translocation of 14C-glyphosate. Moreover, a mutation and an enhanced EPSPS basal activity at target-site level confers higher resistance to glyphosate. These results describe for the first time the glyphosate resistance mechanisms developed by resistant L. virgata populations of citrus orchards from Mexico.

  16. First Resistance Mechanisms Characterization in Glyphosate-Resistant Leptochloa virgata (United States)

    Alcántara-de la Cruz, Ricardo; Rojano-Delgado, Antonia M.; Giménez, María J.; Cruz-Hipolito, Hugo E.; Domínguez-Valenzuela, José A.; Barro, Francisco; De Prado, Rafael


    Leptochloa virgata (L.) P. Beauv. is an annual weed common in citrus groves in the states of Puebla and Veracruz, Mexico limiting their production. Since 2010, several L. virgata populations were identified as being resistant to glyphosate, but studies of their resistance mechanisms developed by this species have been conducted. In this work, three glyphosate-resistant populations (R8, R14, and R15) collected in citrus orchards from Mexico, were used to study their resistance mechanisms comparing them to one susceptible population (S). Dose-response and shikimic acid accumulation assays confirmed the glyphosate resistance of the three resistant populations. Higher doses of up to 720 g ae ha-1 (field dose) were needed to control by 50% plants of resistant populations. The S population absorbed between 7 and 13% more 14C-glyphosate than resistant ones, and translocated up to 32.2% of 14C-glyphosate to the roots at 96 h after treatment (HAT). The R8, R14, and R15 populations translocated only 24.5, 26.5, and 21.9%, respectively. The enzyme activity of 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS) was not different in the S, R8 and R14 populations. The R15 Population exhibited 165.9 times greater EPSPS activity. Additionally, this population showed a higher EPSPS basal activity and a substitution in the codon 106 from Proline to Serine in the EPSPS protein sequence. EPSPS gene expression in the R15 population was similar to that of S population. In conclusion, the three resistant L. virgata populations show reduced absorption and translocation of 14C-glyphosate. Moreover, a mutation and an enhanced EPSPS basal activity at target-site level confers higher resistance to glyphosate. These results describe for the first time the glyphosate resistance mechanisms developed by resistant L. virgata populations of citrus orchards from Mexico. PMID:27917189

  17. Mechanical systems a unified approach to vibrations and controls

    CERN Document Server

    Gans, Roger F


    This essential textbook covers analysis and control of engineering mechanisms, which include almost any apparatus with moving parts used in daily life, from musical instruments to robots. The text  presents both vibrations and controls with considerable breadth and depth using a unified notation. It strikes a nice balance between the analytical and the practical.  This text contains enough material for a two semester sequence, but it can also be used in a single semester course combining the two topics. Mechanical Systems: A Unified Approach to Vibrations and Controls presents a common notation and approach to these closely related areas. Examples from the both vibrations and controls components are integrated throughout this text. This book also: ·         Presents a unified approach to vibrations and controls, including an excellent diagram that simultaneously discusses embedding classical vibrations (mechanical systems) in a discussion of models, inverse models, and open and closed loop control ...

  18. Temperature buffer test. Hydro-mechanical and chemical/ mineralogical characterizations

    Energy Technology Data Exchange (ETDEWEB)

    Aakesson, Mattias; Olsson, Siv; Dueck, Ann; Nilsson, Ulf; Karnland, Ola [Clay Technology AB, Lund (Sweden); Kiviranta, Leena; Kumpulainen, Sirpa [BandTech Oy, Helsinki (Finland); Linden, Johan [Aabo Akademi, Aabo (Finland)


    The Temperature Buffer Test (TBT) is a joint project between SKB/ANDRA and supported by ENRESA (modeling) and DBE (instrumentation), which aims at improving the understanding and to model the thermo-hydro-mechanical behavior of buffers made of swelling clay submitted to high temperatures (over 100 deg C) during the water saturation process. The test has been carried out in a KBS-3 deposition hole at Aspo HRL. It was installed during the spring of 2003. Two steel heaters (3 m long, 0.6 m diameter) and two buffer arrangements have been investigated: the lower heater was surrounded by rings of compacted Wyoming bentonite only, whereas the upper heater was surrounded by a composite barrier, with a sand shield between the heater and the bentonite. The test was dismantled and sampled during the winter of 2009/2010. This report presents the hydro-mechanical and chemical/mineralogical characterization program which was launched subsequent to the dismantling operation. The main goal has been to investigate if any significant differences could be observed between material from the field experiment and the reference material. The field samples were mainly taken from Ring 4 (located at the mid-section around the lower heater), in which the temperature in the innermost part reached 155 deg C. The following hydro-mechanical properties have been determined for the material (test technique within brackets): hydraulic conductivity (swelling pressure device), swelling pressure (swelling pressure device), unconfined compression strength (mechanical press), shear strength (triaxial cell) and retention properties (jar method). The following chemical/mineralogical properties (methods within brackets) were determined: anion analysis of water leachates (IC), chemical composition (ICP/AES+MS, EGA), cation exchange capacity (CEC, Cu-trien method) and exchangeable cations (exchange with NH4, ICPAES), mineralogical composition (XRD and FTIR), element distribution and microstructure (SEM and

  19. Mechanism of Attitude Control Device for Floating Object


    辻, 俊明; 大西, 公平


    This paper describes the new mechanism on attitude control device for unfixed objects. Flywheel is a common attitude control device on spacecraft that provides precise control at an easy rate. However, rapid response is hardly achieved since low reaction torque is available applying flywheel. The purpose in this paper is to improve the response of attitude control device with flywheel. Brake equipment is mounted on the flywheel in order to raise the maximum torque. Maximum torque is raised dr...

  20. Catalytic Synthesis of Oxygenates: Mechanisms, Catalysts and Controlling Characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Klier, Kamil; Herman, Richard G


    This research focused on catalytic synthesis of unsymmetrical ethers as a part of a larger program involving oxygenated products in general, including alcohols, ethers, esters, carboxylic acids and their derivatives that link together environmentally compliant fuels, monomers, and high-value chemicals. The catalysts studied here were solid acids possessing strong Brnsted acid functionalities. The design of these catalysts involved anchoring the acid groups onto inorganic oxides, e.g. surface-grafted acid groups on zirconia, and a new class of mesoporous solid acids, i.e. propylsulfonic acid-derivatized SBA-15. The former catalysts consisted of a high surface concentration of sulfate groups on stable zirconia catalysts. The latter catalyst consists of high surface area, large pore propylsulfonic acid-derivatized silicas, specifically SBA-15. In both cases, the catalyst design and synthesis yielded high concentrations of acid sites in close proximity to one another. These materials have been well-characterization in terms of physical and chemical properties, as well as in regard to surface and bulk characteristics. Both types of catalysts were shown to exhibit high catalytic performance with respect to both activity and selectivity for the bifunctional coupling of alcohols to form ethers, which proceeds via an efficient SN2 reaction mechanism on the proximal acid sites. This commonality of the dual-site SN2 reaction mechanism over acid catalysts provides for maximum reaction rates and control of selectivity by reaction conditions, i.e. pressure, temperature, and reactant concentrations. This research provides the scientific groundwork for synthesis of ethers for energy applications. The synthesized environmentally acceptable ethers, in part derived from natural gas via alcohol intermediates, exhibit high cetane properties, e.g. methylisobutylether with cetane No. of 53 and dimethylether with cetane No. of 55-60, or high octane properties, e.g. diisopropylether with

  1. Flexible microfluidic device for mechanical property characterization of soft viscoelastic solids such as bacterial biofilms. (United States)

    Hohne, Danial N; Younger, John G; Solomon, Michael J


    We introduce a flexible microfluidic device to characterize the mechanical properties of soft viscoelastic solids such as bacterial biofilms. In the device, stress is imposed on a test specimen by the application of a fixed pressure to a thin, flexible poly(dimethyl siloxane) (PDMS) membrane that is in contact with the specimen. The stress is applied by pressurizing a microfabricated air channel located above the test area. The strain resulting from the applied stress is quantified by measuring the membrane deflection with a confocal laser scanning microscope. The deflection is governed by the viscoelastic properties of the PDMS membrane and of the test specimen. The relative contributions of the membrane and test material to the measured deformation are quantified by comparing a finite element analysis with an independent (control) measurement of the PDMS membrane mechanical properties. The flexible microfluidic rheometer was used to characterize both the steady-state elastic modulus and the transient strain recoil of two soft materials: gellan gums and bacterial biofilms. The measured linear elastic moduli and viscoelastic relaxation times of gellan gum solutions were in good agreement with the results of conventional mechanical rheometry. The linear Young's moduli of biofilms of Staphylococcus epidermidis and Klebsiella pneumoniae, which could not be measured using conventional methods, were found to be 3.2 and 1.1 kPa, respectively, and the relaxation time of the S. epidermidis biofilm was 13.8 s. Additionally, strain hardening was observed in all the biofilms studied. Finally, design parameters and detection limits of the method show that the device is capable of characterizing soft viscoelastic solids with elastic moduli in the range of 102-105 Pa. The flexible microfluidic rheometer addresses the need for mechanical property characterization of soft viscoelastic solids common in fields such as biomaterials, food, and consumer products. It requires only 200 p

  2. Modeling and Adaptive Control of a Planar Parallel Mechanism

    Institute of Scientific and Technical Information of China (English)

    敖银辉; 陈新


    Dynamic model and control strategy of parallel mechanism have always been a problem in robotics research. In this paper,different dynamics formulation methods are discussed first, A model of redundant driven parallel mechanism with a planar parallel manipulator is then constructed as an example. A nonlinear adaptive control method is introduced. Matrix pseudo-inversion is used to get a desired actuator torque from a desired end-effector coordinate while the feedback torque is directly calculated in the actuator space. This treatment avoids forward kinematics computation that is very difficult in a parallel mechanism. Experiments with PID together with the descibed adaptive control strategy were carried out for a planar parallel mechanism. The results show that the proposed adaptive controller outperforms conventional PID methods in tracking desired input at a high speed,

  3. The Integrated Control-Mechanism in ATM-Based Networks

    Institute of Scientific and Technical Information of China (English)


    Survivability is one of the important issues in ATM-based networks since even a single network element failure may cause a serious data loss. This paper introduces a new restoration mechanism based on multi-layer ATM survivable network management architecture. This mechanism integrates the general control and restoration control by establishing the Working VPs logical network, Backup VPs logical network and spare logical network in order to optimally utilize the network resources while maintaining the restoration requirements.

  4. The Design of Wheelchair Lifting Mechanism and Control System

    Institute of Scientific and Technical Information of China (English)

    ZHAO Cong; WANG Zheng-xing; JIANG Shi-hong; ZHANG Li; LIU Zheng-yu


    In order to achieve a wheelchair lift function, this paper designs a tri-scissors mechanism. Through the so-called H-type transmission and L-type swing rod, the three scissors mechanisms lift in the same rate with only one liner motor while ensuring the stability of the lift. Finite element analysis in ANSYS is performed to verify the material strength. The control system with Sunplus SCM achieves the voice control of wheelchair walking and lifting.

  5. Mechanics and model-based control of advanced engineering systems

    CERN Document Server

    Irschik, Hans; Krommer, Michael


    Mechanics and Model-Based Control of Advanced Engineering Systems collects 32 contributions presented at the International Workshop on Advanced Dynamics and Model Based Control of Structures and Machines, which took place in St. Petersburg, Russia in July 2012. The workshop continued a series of international workshops, which started with a Japan-Austria Joint Workshop on Mechanics and Model Based Control of Smart Materials and Structures and a Russia-Austria Joint Workshop on Advanced Dynamics and Model Based Control of Structures and Machines. In the present volume, 10 full-length papers based on presentations from Russia, 9 from Austria, 8 from Japan, 3 from Italy, one from Germany and one from Taiwan are included, which represent the state of the art in the field of mechanics and model based control, with particular emphasis on the application of advanced structures and machines.

  6. An Analytical Dynamics Approach to the Control of Mechanical Systems (United States)

    Mylapilli, Harshavardhan

    A new and novel approach to the control of nonlinear mechanical systems is presented in this study. The approach is inspired by recent results in analytical dynamics that deal with the theory of constrained motion. The control requirements on the dynamical system are viewed from an analytical dynamics perspective and the theory of constrained motion is used to recast these control requirements as constraints on the dynamical system. Explicit closed form expressions for the generalized nonlinear control forces are obtained by using the fundamental equation of mechanics. The control so obtained is optimal at each instant of time and causes the constraints to be exactly satisfied. No linearizations and/or approximations of the nonlinear dynamical system are made, and no a priori structure is imposed on the nature of nonlinear controller. Three examples dealing with highly nonlinear complex dynamical systems that are chosen from diverse areas of discrete and continuum mechanics are presented to demonstrate the control approach. The first example deals with the energy control of underactuated inhomogeneous nonlinear lattices (or chains), the second example deals with the synchronization of the motion of multiple coupled slave gyros with that of a master gyro, and the final example deals with the control of incompressible hyperelastic rubber-like thin cantilever beams. Numerical simulations accompanying these examples show the ease, simplicity and the efficacy with which the control methodology can be applied and the accuracy with which the desired control objectives can be met.

  7. Characterization of Heat Waves in the Sahel and associated mechanisms (United States)

    Oueslati, Boutheina; Pohl, Benjamin; Moron, Vincent; Rome, Sandra


    Large efforts are made to investigate the heat waves (HW) in developed countries because of their devastating impacts on society, economy and environment. This interest increased after the intense event over Europe during summer 2003. However, HWs are still understudied over developing countries. This is particularly true in West Africa, and especially in the Sahel, where temperatures recurrently reach critical values, such as during the 2010 HW event. Understanding the Sahelian HWs and associated health risks constitute the main objective of ACASIS, a 4-year project funded by the French Agence Nationale de la Recherche. Our work contributes to this project and aims at characterizing the Sahelian HWs and understanding the mechanisms associated with such extreme events. There is no universal definition of a HW event, since it is highly dependent on the sector (human health, agriculture, transport...) and region of interest. In our case, a HW is defined when the heat index of the day and of the night exceeds the 90th percentile for at least 3 consecutive days (Rome et al. 2016, in preparation). This index combines temperature and relative humidity in order to determine the human-perceived equivalent temperature (definition adapted from Steadman, 1979). Intrinsic properties of Sahelian HW are analyzed from the Global Summary of the Day (GSOD) synoptic observations and ERA-interim reanalyses over 1979-2014 during boreal spring seasons (April-May-June), the warmest period of the year in the Central Sahel. ERA-interim captures well the observed interannual variability and seasonal cycle at the regional scale, as well as the 1979-2014 increasing linear trend of springtime HW occurrences in the Sahel. Reanalyses, however, overestimate the duration, spatial extent of HW, and underestimate their intensity. For both GSOD and ERA-interim, we show that, over the last three decades, Sahelian HWs tend to become more frequent, last longer, cover larger areas and reach higher

  8. Single-atom quantum control of macroscopic mechanical oscillators (United States)

    Bariani, F.; Otterbach, J.; Tan, Huatang; Meystre, P.


    We investigate a hybrid electromechanical system consisting of a pair of charged macroscopic mechanical oscillators coupled to a small ensemble of Rydberg atoms. The resonant dipole-dipole coupling between an internal atomic Rydberg transition and the mechanics allows cooling to its motional ground state with a single atom despite the considerable mass imbalance between the two subsystems. We show that the rich electronic spectrum of Rydberg atoms, combined with their high degree of optical control, paves the way towards implementing various quantum-control protocols for the mechanical oscillators.

  9. Soft Time-Suboptimal Controlling Structure for Mechanical Systems

    DEFF Research Database (Denmark)

    Kulczycki, Piotr; Wisniewski, Rafal; Kowalski, Piotr


    The paper presents conception of a soft control structure based on the time-optimal approach. Its parameters are selected in accordance with the rules of the statistical decision theory and additionally it allows to eliminate rapid changes in control values. The object is a basic mechanical system...

  10. Webcam autofocus mechanism used as a delay line for the characterization of femtosecond pulses

    Energy Technology Data Exchange (ETDEWEB)

    Castro-Marín, Pablo; Kapellmann-Zafra, Gabriel; Garduño-Mejía, Jesús, E-mail:; Rosete-Aguilar, Martha; Román-Moreno, Carlos J. [Centro de Ciencias Aplicadas y Desarrollo Tecnológico, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, A. P. 70-186, CP 04510 México D.F. (Mexico)


    In this work, we present an electromagnetic focusing mechanism (EFM), from a commercial webcam, implemented as a delay line of a femtosecond laser pulse characterization system. The characterization system consists on a second order autocorrelator based on a two-photon-absorption detection. The results presented here were performed for two different home-made femtosecond oscillators: Ti:sapph @ 820 nm and highly chirped pulses generated with an Erbium Doped Fiber @ 1550 nm. The EFM applied as a delay line represents an excellent alternative due its performance in terms of stability, resolution, and long scan range up to 3 ps. Due its low power consumption, the device can be connected through the Universal Serial Bus (USB) port. Details of components, schematics of electronic controls, and detection systems are presented.

  11. The Significance of Sedation Control in Patients Receiving Mechanical Ventilation



    Background Adequate assessment and control of sedation play crucial roles in the proper performance of mechanical ventilation. Methods A total of 30 patients with various pulmonary diseases were prospectively enrolled. The study population was randomized into two groups. The sedation assessment group (SAG) received active protocol-based control of sedation, and in the empiric control group (ECG), the sedation levels were empirically adjusted. Subsequently, daily interruption of sedation (DIS)...

  12. Integrated design of cam mechanisms and servo-control systems

    Institute of Scientific and Technical Information of China (English)

    姚燕安[1; 颜鸿森[2; 张策[3; 邹慧君[4


    Traditionally, in a cam mechanism, the cam is driven by an actuator at a constant speed. The motion characteristics of the follower are determined once the cam profile is designed. This paper presents a novel theory named "integrated design of cam mechanisms and servo-control systems" whose basic idea is varying the input speed trajectory of the cam by a microcomputer-controlled servomotor to improve kinematic and dynamic characteristics of the follower system. The philosophy of the theory is developing superior machines by taking advantage of the flexibility of servo-control systems to compensate for disadvantages of rigid cam mechanisms. The systematic design criteria of the cam-servo-integrated system are developed and an approach based on optimal-control theory is presented for to select suitable cam speed functions, hence the basis of the theory is formed.

  13. Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, and Lactobacillus rhamnosus CLR2 (Bio-K+): Characterization, Manufacture, Mechanisms of Action, and Quality Control of a Specific Probiotic Combination for Primary Prevention of Clostridium difficile Infection. (United States)

    Auclair, Julie; Frappier, Martin; Millette, Mathieu


    A specific probiotic formulation composed of Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, and Lactobacillus rhamnosus CLR2 (Bio-K+) has been marketed in North America since 1996. The strains and the commercial products have been evaluated for safety, identity, gastrointestinal survival, and stability throughout shelf life. The capacity of both the fermented beverages and the capsules to reduce incidences of antibiotic-associated diarrhea and Clostridium difficile infection (CDI) has been demonstrated in human clinical trials. Individual strains and the finished products have shown antimicrobial activity against C. difficile and toxin A/B neutralization capacity in vitro. The use of this specific probiotic formulation as part of a bundle of preventive measures to control CDI in healthcare settings is discussed.

  14. Synthesis of dissipative output feedback controllers. Application to mechanical systems

    Energy Technology Data Exchange (ETDEWEB)

    Johannessen, Erling Aarsand


    This thesis presents new results on the synthesis of linear controllers with passivity, or more general, dissipativity properties. These methods may be applied to obtain more accurate control over mechanical systems and in the control of chemical processes that involve dissipative subsystems. The thesis presents two different approaches for synthesis of dissipative controllers: (1) A method that exploits the Riccati equation solution to the state space formulation of the H{sub {infinity}} control problem is investigated, illustrated by synthesising a controller for damping of flexible modes in a beam. (2) A more general method for dissipative control synthesis is developed that retains the well-known techniques of loop-shaping and frequency weighting in H{sub {infinity}}. A method is also presented for controller synthesis directly from frequency response data. 82 refs., 34 figs., 3 tabs.

  15. Characterization of the mechanical properties of HL-1 cardiomyocytes with high throughput magnetic tweezers

    Energy Technology Data Exchange (ETDEWEB)

    Chen, La; Maybeck, Vanessa; Offenhäusser, Andreas; Krause, Hans-Joachim [Institute of Bioelectronics (ICS-8/PGI-8), Forschungszentrum Jülich GmbH, 52425 Jülich (Germany)


    We characterized the mechanical properties of cardiomyocyte-like HL-1 cells using our recently developed multi-pole magnetic tweezers. With the optimized design, both high force and high throughput are achieved at the same time. Force up to 100 pN can be applied on a 1 μm diameter superparamagnetic bead in a workspace with 60 μm radius, which is encircled symmetrically by 3 sharp magnetic tips. By adjusting the coil currents, both the strength and direction of force can be controlled. The result shows that both viscosity and shear elastic modulus of HL-1 cells exhibit an approximately log-normal distribution. The cells became stiffer as they matured, consistent with a transition from proliferating cells to contractile muscle tissue. Moreover, the mechanical properties of HL-1 cells show high heterogeneity, which agrees well with their physiological structure.

  16. Molecular mechanism of size control in development and human diseases

    Institute of Scientific and Technical Information of China (English)

    Xiaolong Yang; Tian Xu


    How multicellular organisms control their size is a fundamental question that fascinated generations of biologists.In the past 10 years, tremendous progress has been made toward our understanding of the molecular mechanism underlying size control. Original studies from Drosophila showed that in addition to extrinsic nutritional and hormonal cues, intrinsic mechanisms also play important roles in the control of organ size during development. Several novel signaling pathways such as insulin and Hippo-LATS signaling pathways have been identified that control organ size by regulating cell size and/or cell number through modulation of cell growth, cell division, and cell death. Later studies using mammalian cell and mouse models also demonstrated that the signaling pathways identified in flies are also conserved in mammals. Significantly, recent studies showed that dysregulation of size control plays important roles in the development of many human diseases sucha as cancer,diabetes,and hypertrophy.

  17. An Adaptive Variable Structure Control Scheme for Underactuated Mechanical Manipulators

    Directory of Open Access Journals (Sweden)

    Jung Hua Yang


    Full Text Available Mechanical arms have been widely used in the industry for many decades. They have played a dominant role in factory automation. However the control performance, or even system stability, would be deteriorated if some of the actuators fail during the operations. Hence, in this study, an adaptive variable structure scheme is presented to solve this problem. It is shown that, by applying the control mechanism proposed in this paper, the motion of robot systems can maintain asymptotical stability in case of actuators failure. The control algorithms as well as the convergence analysis are theoretically proved based on Lyapunov theory. In addition, to demonstrate the validity of the controller, a number of simulations as well as real-time experiments are also performed for Pendubot robot and Furuta robot systems. The results confirm the applicability of the proposed controller.

  18. Control mechanism of double-rotator-structure ternary optical computer (United States)

    Kai, SONG; Liping, YAN


    Double-rotator-structure ternary optical processor (DRSTOP) has two characteristics, namely, giant data-bits parallel computing and reconfigurable processor, which can handle thousands of data bits in parallel, and can run much faster than computers and other optical computer systems so far. In order to put DRSTOP into practical application, this paper established a series of methods, namely, task classification method, data-bits allocation method, control information generation method, control information formatting and sending method, and decoded results obtaining method and so on. These methods form the control mechanism of DRSTOP. This control mechanism makes DRSTOP become an automated computing platform. Compared with the traditional calculation tools, DRSTOP computing platform can ease the contradiction between high energy consumption and big data computing due to greatly reducing the cost of communications and I/O. Finally, the paper designed a set of experiments for DRSTOP control mechanism to verify its feasibility and correctness. Experimental results showed that the control mechanism is correct, feasible and efficient.

  19. Molecular mechanisms controlling the cell cycle in embryonic stem cells. (United States)

    Abdelalim, Essam M


    Embryonic stem (ES) cells are originated from the inner cell mass of a blastocyst stage embryo. They can proliferate indefinitely, maintain an undifferentiated state (self-renewal), and differentiate into any cell type (pluripotency). ES cells have an unusual cell cycle structure, consists mainly of S phase cells, a short G1 phase and absence of G1/S checkpoint. Cell division and cell cycle progression are controlled by mechanisms ensuring the accurate transmission of genetic information from generation to generation. Therefore, control of cell cycle is a complicated process, involving several signaling pathways. Although great progress has been made on the molecular mechanisms involved in the regulation of ES cell cycle, many regulatory mechanisms remain unknown. This review summarizes the current knowledge about the molecular mechanisms regulating the cell cycle of ES cells and describes the relationship existing between cell cycle progression and the self-renewal.

  20. Testing techniques for mechanical characterization of rapidly solidified materials (United States)

    Koch, C. C.


    Mechanical property testing techniques are reviewed for rapidly solidified materials. Mechanical testing of rapidly solidified materials is complicated by the fact that in most cases at least one dimension of the material is very small (less than 100 microns). For some geometries, i.e., powder or thin surface layers, microhardness is the only feasible mechanical test. The ribbon geometry which is obtained by the melt-spinning method, however, has been used for a variety of mechanical property measurements including elastic properties, tensile properties, fracture toughness, creep, and fatigue. These techniques are described with emphasis placed on the precautions required by the restricted geometry of rapidly solidified specimens.

  1. Mechanically implementable accommodation matrices for passive force control

    Energy Technology Data Exchange (ETDEWEB)

    Goswami, A. [Univ. of Pennsylvania, Philadelphia, PA (United States). Center for Human Modeling and Simulation; Peshkin, M. [Northwestern Univ., Evanston, IL (United States). Dept. of Mechanical Engineering


    Robot force control implemented by means of passive mechanical devices has inherent advantages over active implementations with regard to stability, response rapidity, and physical robustness. The class of devices considered in this paper consists of a Stewart platform-type mechanism interconnected with a network of adjustable mechanical elements such as springs and dampers. The control law repertoire of such a device, imagined as a robot wrist, is given by the range of admittance matrices that it may be programmed to possess. This paper focuses on wrists incorporating damper networks for which the admittance matrices reduce to accommodation or inverse-damping matrices. The authors show that a hydraulic network of fully adjustable damper elements may attain any diagonally dominant accommodation matrix. They describe the technique of selecting the individual damping coefficients to design a desired matrix. They identify the set of dominant matrices as a polyhedral convex cone in the space of matrix entries, and show that each dominant matrix can be composed of a positive linear combination of a fixed set of basis matrices. The overall wrist-accommodation matrix is obtained by projecting the accommodation matrix of the damper network through the wrist kinematics. The linear combination of the dominant basis matrices projected through the wrist kinematics generates the entire space of mechanically implementable force-control laws. The authors quantify the versatility of mechanically implementable force-control laws by comparing this space to the space of all matrices.

  2. Design and control of a high precision drive mechanism (United States)

    Pan, Bo; He, Yongqiang; Wang, Haowei; Zhang, Shuyang; Zhang, Donghua; Wei, Xiaorong; Jiang, Zhihong


    This paper summarizes the development of a high precision drive mechanism (HPDM) for space application, such as the directional antenna, the laser communication device, the mobile camera and other pointing mechanisms. In view of the great practical significance of high precision drive system, control technology for permanent magnet synchronous motor (PMSM) servo system is also studied and a PMSM servo controller is designed in this paper. And the software alignment was applied to the controller to eliminate the steady error of the optical encoder, which helps to realize the 1 arcsec (1σ) control precision. To assess its capabilities, the qualification environment testing including the thermal vacuum cycling testing, and the sinusoidal and random vibration were carried out. The testing results show that the performance of the HPDM is almost the same between the former and the end of each testing.

  3. Combination of the Sorting Line Priority Polling Control Mechanism

    Directory of Open Access Journals (Sweden)

    Wenxue Ran


    Full Text Available The paper proposed the priority polling control mechanism of the unit material combinations sorting lines, and sorters operating process is understood to be the arrival process of orders, service process of each sorter sorts orders and the conversion process between sorting machines. Control process, sorters of the combined sorting lines are divided into the priority sorters and ordinary sorters, priority sorters use full service control, ordinary sorters use limited service (k = 1, applies the polling service system theory, through the embedded Markov chain and probability generating function to establish the mathematical model of the system, the exact solution of the control mechanism of the polling system model and the first and second characteristic parameters, combined with the actual production priority parameters of orders picking for simulation analysis

  4. Assessment of Proper Bonding Methods and Mechanical Characterization FPGA CQFPs (United States)

    Davis, Milton C.


    This presentation discusses fractured leads on field-programmable gate array (FPGA) during flight vibration. Actions taken to determine root cause and resolution of the failure include finite element analysis (FEA) and vibration testing and scanning electron microscopy (with X-ray microanalysis) and energy dispersive spectrometry (SEM/EDS) failure assessment. Bonding methods for surface mount parts is assessed, including critical analysis and assessment of random fatigue damage. Regarding ceramic quad flat pack (CQFP) lead fracture, after disassembling the attitude control electronics (ACE) configuration, photographs showed six leads cracked on FPGA RTSX72SU-1 CQ208B package located on the RWIC card. An identical package (FPGA RTSX32SU-1 CQ208B) mounted on the RWIC did not results in cracked pins due to vibration. FPGA lead failure theories include workmanship issues in the lead-forming, material defect in the leads of the FPGA packages, and the insecure mounting of the board in the card guides, among other theories. Studies were conducted using simple calculations to determine the response and fatigue life of the package. Shorter packages exhibited more response when loaded by out-of-plane displacement of PCB while taller packages exhibit more response when loaded by in-plane acceleration of PCB. Additionally, under-fill did not contribute to reducing stress in leads due to out-of-plane PCB loading or from component twisting, as much as corner bonding. The combination of corner bond and under-fill is best to address mechanical and thermal S/C environment. Test results of bonded parts showed reduced (dampened) amplitude and slightly shifted peaks at the un-bonded natural frequency and an additional response at the bonded frequency. Stress due to PCBB out-of-plane loading was decreased on in the corners when only a corner bond was used. Future work may address CQFP fatigue assessment, including the investigation of discrepancy in predicted fatigue damage, as well as

  5. Mechanisms of active control for noise inside a vibrating cylinder (United States)

    Lester, Harold C.; Fuller, Chris R.


    The active control of propeller-induced noise fields inside a flexible cylinder is studied with attention given to the noise reduction mechanisms inherent in the present coupled acoustic shell model. The active noise control model consists of an infinitely long aluminum cylinder with a radius of 0.4 m and a thickness of 0.001 m. Pressure maps are shown when the two external sources are driven in-phase at a frequency corresponding to Omega = 0.22.

  6. Control of a perturbed under-actuated mechanical system

    KAUST Repository

    Zayane, Chadia


    In this work, the trajectory tracking problem for an under-actuated mechanical system in presence of unknown input disturbances is addressed. The studied inertia wheel inverted pendulum falls in the class of non minimum phase systems. The proposed high order sliding mode control architecture including a controller and differentiator allows to track accurately the predefined trajectory and to stabilize the internal dynamics. The robustness of the proposed approach is illustrated through different perturbation and output noise configurations.

  7. A review of dynamic mechanical characterization of high temperature PMR polyimides and composites (United States)

    Pater, Ruth H.


    This paper reviews the applications of dynamic mechanical characterization for high-temperature PMR polyimides and their graphite-fiber-reinforced composites. This characterization technique provides insights into the processability, performance, and structure property relationships of the polyimides and composites. The dynamic mechanical properties of various molding powders, commercially obtained prepregs, neat resins, and as-fabricated as well as aged composites are presented. Some applied aspects of the dynamic mechanical data are discussed.

  8. Controllable synthesis and characterization of alumina/MWNT nanocomposites

    Energy Technology Data Exchange (ETDEWEB)

    Nemeth, Zoltan; Hernadi, Klara [Department of Applied and Environmental Chemistry, University of Szeged, Rerrich Bela ter 1, 6720 Szeged (Hungary); Marko, Kata; Erdohelyi, Andras [Department of Physical Chemistry and Material Science, University of Szeged, Aradi ter 2, 6720 Szeged (Hungary); Forro, Laszlo [Laboratory of Physics of Complex Matter, IPMC, EPFL, 1026 Ecublens (Switzerland)


    The aim of this work is to develop a controllable synthesis pathway which produces a stable alumina layer on the surface of carbon nanotubes by impregnation method. Precursor compounds such as aluminium isopropoxide and aluminium-acetyl-acetonate were used to cover the surface of multiwalled carbon nanotubes (MWNTs) under different solvent conditions. As-prepared alumina coverages were characterized by TEM, SEM, SEM-EDX, TG and X-ray diffraction techniques. Results revealed that homogeneous coverage can be achieved in a controllable way. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  9. Mechanical Characterization of Anion Exchange Membranes Under Controlled Environmental Conditions (United States)


    increasing ion exchange capacity (IEC) in alkaline exchange quaternary ammonia polysulfone membrane, “a trend that being almost the mirror of the... synthesized in small quantities and processed into films on the order of 10-100 microns thick. Standard tensile tests does not allow for adequate testing of...membrane synthesized from a commercial pentablock copolymer platform was explored. Viscosity and the structure of polymer solutions were investigated

  10. Characterization and development mechanism of Apios americana tuber starch (United States)

    Apios americana is a wild legume-bearing plant with edible tubers. Domestication of Apios is in progress because of the superior nutritional value and health benefits of the tuber. Objectives of this study were to: 1) characterize physicochemical properties of Apios-tuber starch; and 2) understand d...

  11. Characterization of mechanical properties of materials using ultrasound broadband spectroscopy. (United States)

    Agrawal, Megha; Prasad, Abhinav; Bellare, Jayesh R; Seshia, Ashwin A


    This article explores the characterization of homogenous materials (metals, alloys, glass and polymers) by a simple broadband ultrasonic interrogation method. The novelty lies in the use of ultrasound in a continuous way with very low input power (0 dBm or less) and analysis of the transmitted acoustic wave spectrum for material property characterization like speed of sound, density and dimensions of a material. Measurements were conducted on various thicknesses of samples immersed in liquid where continuous-wave, frequency swept ultrasonic energy was incident normal to the sample surface. The electro-acoustic transmission response is analyzed in the frequency domain with respect to a specifically constructed multi-layered analytical model. From the acoustic signature of the sample materials, material properties such as speed of sound and acoustic impedance can be calculated with experimentally derived values found to be in general agreement with the literature and with pulse-echo technique establishing the basis for a non-contact and non-destructive technique for material characterization. Further, by looking at the frequency spacing of the peaks of water when the sample is immersed, the thickness of the sample can be calculated independently from the acoustic response. This technique can prove to be an effective non-contact, non-destructive and fast material characterization technique for a wide variety of materials.

  12. Mechanical characterization of bulk Sylgard 184 for microfluidics and microengineering (United States)

    Johnston, I. D.; McCluskey, D. K.; Tan, C. K. L.; Tracey, M. C.


    Polydimethylsiloxane (PDMS) elastomers are extensively used for soft lithographic replication of microstructures in microfluidic and micro-engineering applications. Elastomeric microstructures are commonly required to fulfil an explicit mechanical role and accordingly their mechanical properties can critically affect device performance. The mechanical properties of elastomers are known to vary with both curing and operational temperatures. However, even for the elastomer most commonly employed in microfluidic applications, Sylgard 184, only a very limited range of data exists regarding the variation in mechanical properties of bulk PDMS with curing temperature. We report an investigation of the variation in the mechanical properties of bulk Sylgard 184 with curing temperature, over the range 25 °C to 200 °C. PDMS samples for tensile and compressive testing were fabricated according to ASTM standards. Data obtained indicates variation in mechanical properties due to curing temperature for Young's modulus of 1.32-2.97 MPa, ultimate tensile strength of 3.51-7.65 MPa, compressive modulus of 117.8-186.9 MPa and ultimate compressive strength of 28.4-51.7 GPa in a range up to 40% strain and hardness of 44-54 ShA.

  13. Improvement Research of Control Rod Drive Mechanism in CARR

    Institute of Scientific and Technical Information of China (English)

    ZHU; Xue-wei; ZHEN; Jian-xiao; LUO; Zhong; YANG; Kun; WANG; Yi-shi; JIA; Yue-guang


    We take an improvement research of synchronization in process of control rod drive mechanism(CRDM)inversion.An experimental prototype is designed based on the structure and function of the CRDM,we take some experiments on this experimental prototype,such as maximum loading force experiment,coil temperature rise experiment and stiffness experiment,achieve important magnetic

  14. Quasivelocities and Optimal Control for Underactuated Mechanical Systems

    CERN Document Server

    Colombo, L


    This paper is concerned with the application of the theory of quasivelocities for optimal control for underactuated mechanical systems. Using this theory, we convert the original problem in a variational second-order lagrangian system subjected to constraints. The equations of motion are geometrically derived using an adaptation of the classical Skinner and Rusk formalism.

  15. Quasivelocities and Optimal Control for underactuated Mechanical Systems (United States)

    Colombo, L.; de Diego, D. Martín


    This paper is concerned with the application of the theory of quasivelocities for optimal control for underactuated mechanical systems. Using this theory, we convert the original problem in a variational second-order lagrangian system subjected to constraints. The equations of motion are geometrically derived using an adaptation of the classical Skinner and Rusk formalism.

  16. Fluid Mechanics of Wing Adaptation for Separation Control (United States)

    Chandrasekhara, M. S.; Wilder, M. C.; Carr, L. W.; Davis, Sanford S. (Technical Monitor)


    The unsteady fluid mechanics associated with use of a dynamically deforming leading edge airfoil for achieving compressible flow separation control has been experimentally studied. Changing the leading edge curvature at rapid rates dramatically alters the flow vorticity dynamics which is responsible for the many effects observed in the flow.

  17. Context-Based E-Health System Access Control Mechanism (United States)

    Al-Neyadi, Fahed; Abawajy, Jemal H.

    E-Health systems logically demand a sufficiently fine-grained authorization policy for access control. The access to medical information should not be just role-based but should also include the contextual condition of the role to access data. In this paper, we present a mechanism to extend the standard role-based access control to incorporate contextual information for making access control decisions in e-health application. We present an architecture consisting of authorisation and context infrastructure that work cooperatively to grant access rights based on context-aware authorization policies and context information.

  18. Pressure and volume controlled mechanical ventilation in anaesthetized pregnant sheep. (United States)

    Davis, J; Musk, G C


    Optimal mechanical ventilation of the pregnant ewe during anaesthesia is of vital importance for maintaining fetal viability. This study aimed to compare peak inspiratory pressure (PIP), oxygenation and cardiovascular parameters with pressure-control (PCV) or volume-control (VCV) mechanical ventilation of anaesthetized pregnant sheep. Twenty ewes at 110 days gestation underwent general anaesthesia in dorsal recumbency for fetal surgery in a research setting. All the sheep were mechanically ventilated; one group with PCV (n = 10) and another with VCV (n = 10) to maintain normocapnia. PIP, direct arterial blood pressure, heart rate, arterial pH and arterial oxygen tension were recorded. PIP was lower in the PCV group (P sheep anaesthetized in dorsal recumbency, though PCV may provide superior oxygenation at a lower PIP.

  19. New methodology for mechanical characterization of human superficial facial tissue anisotropic behaviour in vivo. (United States)

    Then, C; Stassen, B; Depta, K; Silber, G


    Mechanical characterization of human superficial facial tissue has important applications in biomedical science, computer assisted forensics, graphics, and consumer goods development. Specifically, the latter may include facial hair removal devices. Predictive accuracy of numerical models and their ability to elucidate biomechanically relevant questions depends on the acquisition of experimental data and mechanical tissue behavior representation. Anisotropic viscoelastic behavioral characterization of human facial tissue, deformed in vivo with finite strain, however, is sparse. Employing an experimental-numerical approach, a procedure is presented to evaluate multidirectional tensile properties of superficial tissue layers of the face in vivo. Specifically, in addition to stress relaxation, displacement-controlled multi-step ramp-and-hold protocols were performed to separate elastic from inelastic properties. For numerical representation, an anisotropic hyperelastic material model in conjunction with a time domain linear viscoelasticity formulation with Prony series was employed. Model parameters were inversely derived, employing finite element models, using multi-criteria optimization. The methodology provides insight into mechanical superficial facial tissue properties. Experimental data shows pronounced anisotropy, especially with large strain. The stress relaxation rate does not depend on the loading direction, but is strain-dependent. Preconditioning eliminates equilibrium hysteresis effects and leads to stress-strain repeatability. In the preconditioned state tissue stiffness and hysteresis insensitivity to strain rate in the applied range is evident. The employed material model fits the nonlinear anisotropic elastic results and the viscoelasticity model reasonably reproduces time-dependent results. Inversely deduced maximum anisotropic long-term shear modulus of linear elasticity is G∞,max(aniso)=2.43kPa and instantaneous initial shear modulus at an

  20. The Effect of Headquarter Integration Mechanisms on Subsidiaries’ New Product Success: From Control to Coordination Mechanism

    Directory of Open Access Journals (Sweden)



    Full Text Available New product launching (NPL to the local market by subsidiary managers is a strategic activity, which requires organizational supports from MNC global network. The NPL activity is marked by high level of uncertainty, risk, and market failure. Thus, a headquarter needs to integrate the subsidiary NPL into global strategy. There are two mechanisms to integrate subsidiaries’ activities during NPL process; coordination and control process. By testing the effect of each mechanism on role clarity and functional conflict, I found that coordination mechanism increase role clarity between headquarter and subsidiaries’ managers. In contrast, exercising control mechanism reduces role clarity and functional conflict between headquarter and subsidiaries’ managers during NPL. This research shows that both role clarity and functional conflict increase new product commercial performance introduced by subsidiary in the local market.

  1. Measurements and Characterizations of Mechanical Properties of Human Skins (United States)

    Song, Han Wook; Park, Yon Kyu

    A skin is an indispensible organ for humans because it contributes to metabolism using its own biochemical functions and protects the human body from external stimuli. Recently, mechanical properties such as a thickness, a friction and an elastic coefficient have been used as a decision index in the skin physiology and in the skin care market due to the increased awareness of wellbeing issues. In addition, the use of mechanical properties is known to have good discrimination ability in the classification of human constitutions, which are used in the field of an alternative medicine. In this study, a system that measures mechanical properties such as a friction and an elastic coefficient is designed. The equipment consists of a load cell type (manufactured by the authors) for the measurements of a friction coefficient, a decompression tube for the measurement of an elastic coefficient. Using the proposed system, the mechanical properties of human skins from different constitutions were compared, and the relative repeatability error for measurements of mechanical properties was determined to be less than 2%. Combining the inspection results of medical doctors in the field of an alternative medicine, we could conclude that the proposed system might be applicable to a quantitative constitutional diagnosis between human constitutions within an acceptable level of uncertainty.

  2. A New Lyapunov Based Robust Control for Uncertain Mechanical Systems

    Institute of Scientific and Technical Information of China (English)

    ZHEN Sheng-Chao; ZHAO Han; CHEN Ye-Hwa; HUANG Kang


    We design a new robust controller for uncertain mechanical systems. The inertia matrix0s singularity and upper bound property are first analyzed. It is shown that the inertia matrix may be positive semi-definite due to over-simplified model. Further-more, the inertia matrix0s being uniformly bounded above is also limited. A robust controller is proposed to suppress the effect of uncertainty in mechanical systems with the assumption of uniform positive definiteness and upper bound of the inertia matrix. We theoretically prove that the robust control renders uniform boundedness and uniform ultimate boundedness. The size of the ultimate boundedness ball can be made arbitrarily small by the designer. Simulation results are presented and discussed.

  3. Optimal piezo-electro-mechanical coupling to control plate vibrations

    CERN Document Server

    Alessandroni, S; Frezza, F


    A new way of coupling electrical and mechanical waves, using piezoelectric effect, is presented here. Since the energy exchange between two systems supporting wave propagation is maximum when their evolution is governed by similar equations, hence, an optimal electromechanical coupling is obtained by designing an electric network which is "analog" to the mechanical structure to be controlled. In this paper, we exploit this idea to enhance the coupling, between a Kirchhoff-Love plate and one possible synthesis of its circuital analog, as obtained by means of a set of piezoelectric actuators uniformly distributed upon the plate. It is shown how this approach allows for an optimal energy exchange between the mechanic and the electric forms independent of the modal evolution of the structure. Moreover, we show how an efficient electric dissipation of the mechanical energy can be obtained adding dissipative elements in the electric network.

  4. Control of autoresonance in mechanical and physical models (United States)

    Kovaleva, A.


    Autoresonant energy transfer has been considered as one of the most effective methods of excitation and control of high-energy oscillations for a broad range of physical and engineering systems. Nonlinear time-invariant feedback control provides effective self-tuning and self-adaptation mechanisms targeted at preserving resonance oscillations under variations of the system parameters but its implementation may become extremely complicated. A large class of systems can avoid nonlinear feedback, still producing the required state due to time-variant feed-forward frequency control. This type of control in oscillator arrays employs an intrinsic property of a nonlinear oscillator to vary both its amplitude and the frequency when the driving frequency changes. This paper presents a survey of recently published and new results studying possibilities and limitations of time-variant frequency control in nonlinear oscillator arrays. This article is part of the themed issue 'Horizons of cybernetical physics'.

  5. NH4-smectite: Characterization, hydration properties and hydro mechanical behaviour



    International audience; Leachates in waste landfills are characterized by the presence of ammonium ions in large excess. These ammonium ions can be exchanged with the interlayer cations in clay and modify the physical and chemical properties of clay geochemical barriers in waste landfills and drive to environmental problems. The purpose of this study was to understand the hydro-physical changes of a smectite in the presence of ammonium ions. An ammonium smectite was prepared by cation exchang...

  6. The Mechanics and Trajectory Control in Locust Jumping

    Institute of Scientific and Technical Information of China (English)

    Longbao Han; Zhouyi Wang; Aihong Ji; Zhendong Dai


    Locusts (Locusta migratoria manilensis) are characterised by their flying ability and abiding jump ability.Research on the jumping mechanics and behavior of locusts plays an important role in elucidating the mechanism of hexapod locomotion.The jump gestures of locusts were observed using high-speed video camera at 250 fps.The reaction forces of the hindlegs were measured using two three-dimensional sensors,in case the two hindlegs attached on separated sensor plates.The jump gestures and reaction forces were used to illustrate the locust jumping mechanism.Results show that the trajectory control is achieved by rapid rolling and yawing movements of the locust body,caused by the forelegs,midlegs and hindlegs in different jumping phases.The final jump trajectory was not determined until hind tarsi left platform.The horizontal co-impulse between two hindlegs might play a key role in jump stability and accuracy.Besides,the angle between two hindlegs affects the control of jump trajectory but has a little effect on the elevation angle of a jump,which is controlled mechanically by the initial position of the hindlegs.This research lays the groundwork for the probable design and development of biomimetic robotics.

  7. Flow around a semicircular cylinder with passive flow control mechanisms (United States)

    Hamed, A. M.; Vega, J.; Liu, B.; Chamorro, L. P.


    Wind tunnel experiments were performed to study the effect of passive flow control strategies on the wake and drag of a semicircular cylinder of infinite aspect ratio. High-resolution planar particle image velocimetry was used to obtain flow statistics around the semicircular cylinder at Reynolds number Re≈ 3.2× 10^4 based on the cylinder diameter. The control mechanisms under consideration include rigid flaps of various lengths placed at the edges of the structure and a small slot along the symmetry plane of the cylinder. Mean velocity fields reveal the distinctive effects of each passive mechanism on the flow, such as velocity recovery, size of the recirculation bubble and location of the reattachment point. The distributions of turbulence kinetic energy and kinematic shear stress show the modulation of each passive control mechanism on the wake, including the onset and location of the maximum turbulence levels. Instantaneous and mean fields of swirling strength further highlight the role of the passive mechanisms in the vortex dynamics. Drag coefficient for the various cases was estimated indirectly from the flow measurements using a momentum balance. This approach shows that long flaps and slot were able to reduce drag with respect to the base case. The rigid flaps with length coincident with the diameter of the cylinder offered the best performance with drag reduction of ˜25%.

  8. Adaptive mechanism-based congestion control for networked systems (United States)

    Liu, Zhi; Zhang, Yun; Chen, C. L. Philip


    In order to assure the communication quality in network systems with heavy traffic and limited bandwidth, a new ATRED (adaptive thresholds random early detection) congestion control algorithm is proposed for the congestion avoidance and resource management of network systems. Different to the traditional AQM (active queue management) algorithms, the control parameters of ATRED are not configured statically, but dynamically adjusted by the adaptive mechanism. By integrating with the adaptive strategy, ATRED alleviates the tuning difficulty of RED (random early detection) and shows a better control on the queue management, and achieve a more robust performance than RED under varying network conditions. Furthermore, a dynamic transmission control protocol-AQM control system using ATRED controller is introduced for the systematic analysis. It is proved that the stability of the network system can be guaranteed when the adaptive mechanism is finely designed. Simulation studies show the proposed ATRED algorithm achieves a good performance in varying network environments, which is superior to the RED and Gentle-RED algorithm, and providing more reliable service under varying network conditions.

  9. Strain-controlled criticality governs the nonlinear mechanics of fibre networks

    CERN Document Server

    Sharma, A; Rens, R; Sheinman, M; Jansen, K A; Koenderink, G H; MacKintosh, F C


    Disordered fibrous networks are ubiquitous in nature as major structural components of living cells and tissues. The mechanical stability of networks generally depends on the degree of connectivity: only when the average number of connections between nodes exceeds the isostatic threshold are networks stable (Maxwell, J. C., Philosophical Magazine 27, 294 (1864)). Upon increasing the connectivity through this point, such networks undergo a mechanical phase transition from a floppy to a rigid phase. However, even sub-isostatic networks become rigid when subjected to sufficiently large deformations. To study this strain-controlled transition, we perform a combination of computational modeling of fibre networks and experiments on networks of type I collagen fibers, which are crucial for the integrity of biological tissues. We show theoretically that the development of rigidity is characterized by a strain-controlled continuous phase transition with signatures of criticality. Our experiments demonstrate mechanical...

  10. The Dark Energy Spectroscopic Instrument (DESI) instrument mechanism control systems (United States)

    Coker, Carl T.; Pappalardo, Daniel; Pogge, Richard; Martini, Paul; Derwent, Mark; O'Brien, Thomas P.; Honscheid, Klaus


    The Dark Energy Spectroscopic Instrument (DESI) is under construction to measure the expansion history of the Universe using the Baryon Acoustic Oscillation technique. The spectra of 40 million galaxies over 14,000 sq deg will be measured during the life of the experiment. A new prime focus corrector for the KPNO Mayall telescope will deliver light to 5,000 fiber optic positioners. The fibers in turn feed ten broad-band spectrographs. We present the design details of the instrument mechanism control systems for the spectrographs. Each spectrograph has a stand-alone mechanism control box that operates the unit's four remotely-operated mechanisms (two shutters and two Hartmannn doors), and provides a suite of temperature and humidity sensors. Each control box is highly modular, and is operated by a dedicated on-board Linux computer to provide all of the control and monitoring functions. We describe our solution for integrating a number of network-connected devices within each unit spectrograph, and describe the basic software architecture.

  11. Mechanical characterization of hydroxyapatite, thermoelectric materials and doped ceria (United States)

    Fan, Xiaofeng

    For a variety of applications of brittle ceramic materials, porosity plays a critical role structurally and/or functionally, such as in engineered bone scaffolds, thermoelectric materials and in solid oxide fuel cells. The presence of porosity will affect the mechanical properties, which are essential to the design and application of porous brittle materials. In this study, the mechanical property versus microstructure relations for bioceramics, thermoelectric (TE) materials and solid oxide fuel cells were investigated. For the bioceramic material hydroxyapatite (HA), the Young's modulus was measured using resonant ultrasound spectroscopy (RUS) as a function of (i) porosity and (ii) microcracking damage state. The fracture strength was measured as a function of porosity using biaxial flexure testing, and the distribution of the fracture strength was studied by Weibull analysis. For the natural mineral tetrahedrite based solid solution thermoelectric material (Cu10Zn2As4S13 - Cu 12Sb4S13), the elastic moduli, hardness and fracture toughness were studied as a function of (i) composition and (ii) ball milling time. For ZiNiSn, a thermoelectric half-Heusler compound, the elastic modulus---porosity and hardness---porosity relations were examined. For the solid oxide fuel cell material, gadolina doped ceria (GDC), the elastic moduli including Young's modulus, shear modulus, bulk modulus and Poisson's ratio were measured by RUS as a function of porosity. The hardness was evaluated by Vickers indentation technique as a function of porosity. The results of the mechanical property versus microstructure relations obtained in this study are of great importance for the design and fabrication of reliable components with service life and a safety factor. The Weibull modulus, which is a measure of the scatter in fracture strength, is the gauge of the mechanical reliability. The elastic moduli and Poisson's ratio are needed in analytical or numerical models of the thermal and

  12. Mechanical characterization of glancing angle deposited Si nanostructures

    Energy Technology Data Exchange (ETDEWEB)

    Miessler, Andre; Patzig, Christian; Rauschenbach, Bernd [Leibniz Institute of Surface Modification, Leipzig (Germany); Fuhrmann, Bodo [Martin-Luther-Universitaet Halle, Halle (Germany)


    In physical vapour deposition processes the incoming particle flux strikes perpendicular to the surface, whereas a compact film is deposed on the substrate. However, at the glancing angle deposition (GLAD) process the sample is tilted with respect to the substrate normal, so the particle flux strikes the surface under an highly oblique angle {beta} (typically {beta}>80 with respect to the substrate normal). Self-shadowing of the deposed particles lead to a non-closed and highly porous film, which is compose of needle-like nanostructures, toward the incoming particle flux. By means of substrate rotation, different structures such as pillars, zigzags, screws or spirals can be obtained. Although in recent years a series of fundamentally findings have been published, mechanical properties remain unknown. Our goal was to determine the mechanical properties (such as hardness, Young's modulus and spring constants of spiral structures) by employing nanoindentation with a flat punch to these 3D silicon nanostructures.

  13. Characterization of Mechanical Properties of Porcelain Tile Using Ultrasonics


    KURAMA, Semra; Eren, Elif


    Ultrasound affords a very useful and versatile non-destructive method, using a large application area, for evaluating the microstructure and mechanical properties of materials. In this study, porcelain tiles were sintered at different temperatures to change their porosity. Following this, the time of flight of both longitudinal and shear waves was measured through the tile. The time of flight of ultrasonic waves was measured using a contact ultrasonic transducer operating on a pulse-echo mode...

  14. Characterization of the mechanisms for coal solubilization by filamentous fungi

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, M.; Luna, N.; Monistrol, I.F.; Laborda, F. [Madrid Univ. (Spain). Dept. de Microbiologia y Parasitologia


    The mechanisms implicated on coal solubilization have been studied in this work. Two fungal strains (Trichoderma and Penicillium) has been isolated which were able to solubilize different kinds of Spanish coals (hard coal, subbituminous coal and lignite) when growing in liquid media in the presence of coal. Extracellular peroxidase, esterase and some times phenol oxidase enzymes were present in the culture supernatant when a high degree of coal solubilization was attained. Those enzymes could be involved in the coal attack. (orig.)

  15. Mechanical Characterization of Cotton Fiber/Polyester Composite Material

    Directory of Open Access Journals (Sweden)

    Altaf Hussain Rajper


    Full Text Available Development of composite from natural fiber for lower structural application is growing for long-term sustainable perspective. Cotton fiber composite material has the added advantages of high specific strength, corrosion resistance, low cost and low weight compared to glass fiber on the expense of internal components of IC engines. The primary aim of the research study is to examine the effect of the cotton fiber on mechanical properties of lower structural applications when added with the polyester resin. In this paper composite material sample has been prepared by hand Lay-Up process. A mould is locally developed in the laboratory for test sample preparation. Initially samples of polyester resin with appropriate ratio of the hardener were developed and tested. At the second stage yarns of cotton fiber were mixed with the polyester resin and sample specimens were developed and tested. Relative effect of the cotton as reinforcing agent was examined and observed that developed composite specimen possess significant improvement in mechanical properties such as tensile strength was improved as 19.78 % and modulus of elasticity was increased up to 24.81%. Through this research it was also observed that developed composite material was of ductile nature and its density decreases up to 2.6%. Results from this study were compared with relevant available advanced composite materials and found improved mechanical properties of developed composite material

  16. Altered neuromuscular control mechanisms of the trapezius muscle in fibromyalgia

    Directory of Open Access Journals (Sweden)

    Karlsson Stefan J


    Full Text Available Abstract Background fibromyalgia is a relatively common condition with widespread pain and pressure allodynia, but unknown aetiology. For decades, the association between motor control strategies and chronic pain has been a topic for debate. One long held functional neuromuscular control mechanism is differential activation between regions within a single muscle. The aim of this study was to investigate differences in neuromuscular control, i.e. differential activation, between myalgic trapezius in fibromyalgia patients and healthy controls. Methods 27 fibromyalgia patients and 30 healthy controls performed 3 minutes bilateral shoulder elevations with different loads (0-4 Kg with a high-density surface electromyographical (EMG grid placed above the upper trapezius. Differential activation was quantified by the power spectral median frequency of the difference in EMG amplitude between the cranial and caudal parts of the upper trapezius. The average duration of the differential activation was described by the inverse of the median frequency of the differential activations. Results the median frequency of the differential activations was significantly lower, and the average duration of the differential activations significantly longer in fibromyalgia compared with controls at the two lowest load levels (0-1 Kg (p Conclusion these findings illustrate a different neuromuscular control between fibromyalgia patients and healthy controls during a low load functional task, either sustaining or resulting from the chronic painful condition. The findings may have clinical relevance for rehabilitation strategies for fibromyalgia.

  17. Mechanisms of motor adaptation in reactive balance control.

    Directory of Open Access Journals (Sweden)

    Torrence D J Welch

    Full Text Available Balance control must be rapidly modified to provide stability in the face of environmental challenges. Although changes in reactive balance over repeated perturbations have been observed previously, only anticipatory postural adjustments preceding voluntary movements have been studied in the framework of motor adaptation and learning theory. Here, we hypothesized that adaptation occurs in task-level balance control during responses to perturbations due to central changes in the control of both anticipatory and reactive components of balance. Our adaptation paradigm consisted of a Training set of forward support-surface perturbations, a Reversal set of novel countermanding perturbations that reversed direction, and a Washout set identical to the Training set. Adaptation was characterized by a change in a motor variable from the beginning to the end of each set, the presence of aftereffects at the beginning of the Washout set when the novel perturbations were removed, and a return of the variable at the end of the Washout to a level comparable to the end of the Training set. Task-level balance performance was characterized by peak center of mass (CoM excursion and velocity, which showed adaptive changes with repetitive trials. Only small changes in anticipatory postural control, characterized by body lean and background muscle activity were observed. Adaptation was found in the evoked long-latency muscular response, and also in the sensorimotor transformation mediating that response. Finally, in each set, temporal patterns of muscle activity converged towards an optimum predicted by a trade-off between maximizing motor performance and minimizing muscle activity. Our results suggest that adaptation in balance, as well as other motor tasks, is mediated by altering central sensitivity to perturbations and may be driven by energetic considerations.

  18. The contact density to characterize the mechanics of cohesive granular materials: application to snow microstructure modeling. (United States)

    Gaume, Johan; Löwe, Henning


    Microstructural properties are essential to characterize the mechanics of loose and cohesive granular materials such as snow. In particular, mechanical properties and physical processes of porous media are often related to the volume fraction ν. Low-density microstructures typically allow for considerable structural diversity at a given volume fraction, leading to uncertainties in modeling approaches using ν-based parametrizations only. We have conducted discrete element simulations of cohesive granular materials with initial configurations which are drawn from Baxter's sticky hard sphere (SHS) model. This method allows to control independently the initial volume fraction ν and the average coordination number Z. We show that variations in elasticity and strength of the samples can be fully explained by the initial contact density C = νZ over a wide range of volume fractions and coordination numbers. Hence, accounting for the contact density C allows to resolve the discrepancies in particle based modeling between samples with similar volume fractions but different microstructures. As an application, we applied our method to the microstructure of real snow samples which have been imaged by micro-computed tomography and reconstructed using the SHS model. Our new approach opens a promising route to evaluate snow physical and mechanical properties from field measurements, for instance using the Snow Micro Penetrometer (SMP), by linking the penetration resistance to the contact density.

  19. Structural, mechanical and electrical characterization of epoxy-amine/carbon black nanonocomposites

    Directory of Open Access Journals (Sweden)


    Full Text Available This work presents an insight into the effect of preparation procedure and the filler content on both electrical and mechanical properties of a nanocomposite system. For the preparation of the nanocomposites diglycidyl ether of bisphenol A (DGEBA was used with triethylenetetramine (TETA as a curing agent. As fillers carbon black (CB nanoparticles with size from 25 to 75 nm were used. The characterization was done using Dynamic Mechanical Analysis (DMA, Dielectric Relaxation Spectroscopy (DRS, Differential Scanning Calorimetry (DSC, Wide Angle X-ray Diffraction (WAXD and electrical conductivity measurements. The dependence of the dynamic mechanical and dielectric parameters (E′, E″, tanδ, ε', ε″, σ and Tg is associated with the filler content and is controlled by the employed curing conditions. An increase in electrical conductivity, which is observed at about 1% w/w of carbon black, indicates the creation of conducting paths and is associated with the Maxwell Wagner Sillars (MWS relaxation, probably due to the formation of aggregated microstructures in the bulk composite..

  20. Comparative Study on New AQM Mechanisms for Congestion Control

    Directory of Open Access Journals (Sweden)

    Ramakrishna B B


    Full Text Available As usage of network goes increasing day by day, managing network traffic becomes a very difficult task. It is important to avoid high packet loss rates in the Internet. Congestion is the one of the major issue in the present networks. Congestion Control is one of the solutions adopted to solve the congestion issue and to control it. Numbers of queue management algorithms are proposed for congestion control and to reduce high packet loss rates. Active Queue Management (AQM is one such mechanism which provides better control over congestion. In this paper a study is made on recent load based AQM techniques that are proposed and its merits and shortfall is presented.

  1. Biomimetic Control of Mechanical Systems Equipped with Musculotendon Actuators

    Institute of Scientific and Technical Information of China (English)

    Javier Moreno-Valenzuela; Adriana Salinas-Avila


    This paper addresses the problem of modelling, control, and simulation of a mechanical system actuated by an agonist-antagonist musculotendon subsystem. Contraction dynamics is given by case I of Zajac's model. Saturated semi positive proportional-derivative-type controllers with switching as neural excitation inputs are proposed. Stability theory of switched system and SOSTOOLS, which is a sum of squares optimization toolbox of Matlab, are used to determine the stability of the obtained closed-loop system. To corroborate the obtained theoretical results numerical simulations are carried out. As additional contribution, the discussed ideas are applied to the biomimetic control of a DC motor, i.e., the position control is addressed assuming the presence of musculotendon actuators. Real-experiments corroborate the expected results.

  2. Controlling chaos based on an adaptive nonlinear compensator mechanism

    Institute of Scientific and Technical Information of China (English)

    Tian Ling-Ling; Li Dong-Hai; Sun Xian-Fang


    The control problems of chaotic systems are investigated in the presence of parametric uncertainty and persistent external disturbances based on nonlinear control theory.By using a designed nonlinear compensator mechanism,the system deterministic nonlinearity,parametric uncertainty and disturbance effect can be compensated effectively.The renowned chaotic Lorenz system subjected to parametric variations and external disturbances is studied as an illustrative example.From the Lyapunov stability theory,sufficient conditions for choosing control parameters to guarantee chaos control are derived.Several experiments are carried out,including parameter change experiments,set-point change experiments and disturbance experiments.Simulation results indicate that the chaotic motion can be regulated not only to steady states but also to any desired periodic orbits with great immunity to parametric variations and external disturbances.

  3. Integrated automated nanomanipulation and real-time cellular surface imaging for mechanical properties characterization (United States)

    Eslami, Sohrab; Zareian, Ramin; Jalili, Nader


    Surface microscopy of individual biological cells is essential for determining the patterns of cell migration to study the tumor formation or metastasis. This paper presents a correlated and effective theoretical and experimental technique to automatically address the biophysical and mechanical properties and acquire live images of biological cells which are of interest in studying cancer. In the theoretical part, a distributed-parameters model as the comprehensive representation of the microcantilever is presented along with a model of the contact force as a function of the indentation depth and mechanical properties of the biological sample. Analysis of the transfer function of the whole system in the frequency domain is carried out to characterize the stiffness and damping coefficients of the sample. In the experimental section, unlike the conventional atomic force microscope techniques basically using the laser for determining the deflection of microcantilever's tip, a piezoresistive microcantilever serving as a force sensor is implemented to produce the appropriate voltage and measure the deflection of the microcantilever. A micromanipulator robotic system is integrated with the MATLAB® and programmed in such a way to automatically control the microcantilever mounted on the tip of the micromanipulator to achieve the topography of biological samples including the human corneal cells. For this purpose, the human primary corneal fibroblasts are extracted and adhered on a sterilized culture dish and prepared to attain their topographical image. The proposed methodology herein allows an approach to obtain 2D quality images of cells being comparatively cost effective and extendable to obtain 3D images of individual cells. The characterized mechanical properties of the human corneal cell are furthermore established by comparing and validating the phase shift of the theoretical and experimental results of the frequency response.

  4. Optimal control of underactuated mechanical systems: A geometric approach (United States)

    Colombo, Leonardo; Martín De Diego, David; Zuccalli, Marcela


    In this paper, we consider a geometric formalism for optimal control of underactuated mechanical systems. Our techniques are an adaptation of the classical Skinner and Rusk approach for the case of Lagrangian dynamics with higher-order constraints. We study a regular case where it is possible to establish a symplectic framework and, as a consequence, to obtain a unique vector field determining the dynamics of the optimal control problem. These developments will allow us to develop a new class of geometric integrators based on discrete variational calculus.

  5. Optimal Control of Underactuated Mechanical Systems: A Geometric Approach

    CERN Document Server

    Colombo, L; Zuccalli, M


    In this paper, we consider a geometric formalism for optimal control of underactuated mechanical systems. Our techniques are an adaptation of the classical Skinner and Rusk approach for the case of Lagrangian dynamics with higher-order constraints. We study a regular case where it is possible to establish a symplectic framework and, as a consequence, to obtain a unique vector field determining the dynamics of the optimal control problem. These developments will allow us to develop a new class of geometric integrators based on discrete variational calculus.

  6. Antenna mechanism of length control of actin cables

    CERN Document Server

    Mohapatra, Lishibanya; Kondev, Jane


    Actin cables are linear cytoskeletal structures that serve as tracks for myosin-based intracellular transport of vesicles and organelles in both yeast and mammalian cells. In a yeast cell undergoing budding, cables are in constant dynamic turnover yet some cables grow from the bud neck toward the back of the mother cell until their length roughly equals the diameter of the mother cell. This raises the question: how is the length of these cables controlled? Here we describe a novel molecular mechanism for cable length control inspired by recent experimental observations in cells. This antenna mechanism involves three key proteins: formins, which polymerize actin, Smy1 proteins, which bind formins and inhibit actin polymerization, and myosin motors, which deliver Smy1 to formins, leading to a length-dependent actin polymerization rate. We compute the probability distribution of cable lengths as a function of several experimentally tuneable parameters such as the formin-binding affinity of Smy1 and the concentra...

  7. Mechanization and Control Concepts for Biologically Inspired Micro Aerial Vehicles (United States)

    Raney, David L.; Slominski, Eric C.


    It is possible that MAV designs of the future will exploit flapping flight in order to perform missions that require extreme agility, such as rapid flight beneath a forest canopy or within the confines of a building. Many of nature's most agile flyers generate flapping motions through resonant excitation of an aeroelastically tailored structure: muscle tissue is used to excite a vibratory mode of their flexible wing structure that creates propulsion and lift. A number of MAV concepts have been proposed that would operate in a similar fashion. This paper describes an ongoing research activity in which mechanization and control concepts with application to resonant flapping MAVs are being explored. Structural approaches, mechanical design, sensing and wingbeat control concepts inspired by hummingbirds, bats and insects are examined. Experimental results from a testbed capable of generating vibratory wingbeat patterns that approximately match those exhibited by hummingbirds in hover, cruise, and reverse flight are presented.

  8. Sum of Roots Characterization for H2 Control Performance Limitations (United States)

    Hara, Shinji; Kanno, Masaaki

    This paper provides new expressions of H2 control performance limits achievable by feedback for SISO continuous-time systems. The result for the regulation problem is expressed in a simple manner in terms of two sums of roots obtained from the plant and the associated polynomial spectral factorization. We show that it can connect the two existing solutions, namely the Riccati solution and the analytical expression with an integral form. The similar result for the tracking problem is also derived using the reciprocal transform. Finally parametric optimization making use of the derived expression by means of symbolic computation is demonstrated to confirm the validity of the sum of roots characterization.

  9. Small-scale mechanical characterization of viscoelastic adhesive systems (United States)

    Shean, T. A. V.

    Aero engine hot end components are often covered with ceramic Thermal Barrier Coatings (TBCs). Laser drilling in the TBC coated components can be a source of service life TBC degradation and spallation. The present study aims to understand the mechanisms of TBC delamination and develop techniques to drill holes without damaging the TBC, Nimonic 263 workpieces coated with TBC are used in the experiments. Microwave non-destructive testing (NDT) is employed to monitor the integrity of the coating /substrate interfaces of the post-laser drilled materials. A numerical modelling technique is used to investigate the role of melt ejection on TBC delamination. The model accounts for the vapour and the assist gas flow effects in the process. Broadly, melt ejection induced mechanical stresses for the TBC coating / bond coating and thermal effects for the bond coating / substrate interfaces are found the key delamination mechanisms. Experiments are carried out to validate the findings from the model. Various techniques that enable laser drilling without damaging the TBC are demonstrated. Twin jet assisted acute angle laser drilling is one successful technique that has been analysed using the melt ejection simulation. Optimisation of the twin jet assisted acute angle laser drilling process parameters is carried out using Design of Experiments (DoE) and statistical modelling approaches. Finally, an industrial case study to develop a high speed, high quality laser drilling system for combustor cans is described. Holes are drilled by percussion and trepan drilling in TBC coated and uncoated Haynes 230 workpieces. The production rate of percussion drilling is significantly higher than the trepan drilling, however metallurgical hole quality and reproducibility is poor. A number of process parameters are investigated to improve these characteristics. Gas type and gas pressure effects on various characteristics of the inclined laser drilled holes are investigated through theoretical

  10. A Dynamic Adaptive Layered Multicast Congestion Control Mechanism

    Institute of Scientific and Technical Information of China (English)

    REN Liyong; LU Xianliang; WEI Qingsong; ZHOU Xu


    To solve the problem that most of existing layered multicast protocols cannot adapt to dynamic network conditions because their layers are coarsely granulated and static, a new congestion control mechanism for dynamic adaptive layered multicast(DALM) is presented. In this mechanism, a novel feedback aggregating algorithm is put forward, which can dynamically determine the number of layers and the rate of each layer, and can efficiently improve network bandwidth utilization ratio.Additionally, because all layers is transmitted in only one group, the intricate and time-consuming internet group management protocol(IGMP) operations, caused by receiver joining a new layer or leaving the topmost subscribed layer, are thoroughly eliminated. And this mechanism also avoids other problems resulted from multiple groups. Simulation results show that DALM is adaptive and TCP friendly.

  11. Invasive mechanism and control strategy of Ageratina adenophora (Sprengel)

    Institute of Scientific and Technical Information of China (English)


    In order to ascertain the invasive mechanism and control strategy of the invasive Crofton weed, Ageratina adenophora, its ecological adaptability and population differentiation,the formation of single dominant population, displacement of native plants and sustainable management strategies were investigated. The present results helped to clarify and explain such issues as the adaptability post invasion,interaction and competition between inter-and intra-species and community resistance, thereby providing important references to researches on other invasive alien species.

  12. Immunosensor with Fluid Control Mechanism for Salivary Cortisol Analysis


    Yamaguchi, Masaki; Matsuda, Yohei; Sasaki, Shohei; Sasaki, Makoto; Kadoma, Yoshihiro; Imai, Yoshikatsu; Niwa, Daisuke; Shetty, Vivek


    The purpose of this research is to demonstrate a new design for a cortisol immunosensor for the noninvasive and quantitative analysis of salivary cortisol. We propose a cortisol immunosensor with a fluid control mechanism which has both a vertical flow and a lateral flow. The detected current resulting from a competitive reaction between the sample cortisol and a glucose oxidase (GOD)-labeled cortisol conjugate was found to be inversely related to the concentration of cortisol in the sample s...

  13. Mechanisms of control of microRNA biogenesis


    Davis-Dusenbery, Brandi N.; Hata, Akiko


    MicroRNAs (miRNAs) are a class of ∼22 nt non-coding RNAs that control diverse biological functions in animals, plants and unicellular eukaryotes by promoting degradation or inhibition of translation of target mRNAs. miRNA expression is often tissue specific and developmentally regulated. Aberrant expression of miRNAs has been linked to developmental abnormalities and human diseases, including cancer and cardiovascular disorders. The recent identification of mechanisms of miRNA biogenesis regu...

  14. Multi-finger prehension: control of a redundant mechanical system. (United States)

    Latash, Mark L; Zatsiorsky, Vladimir M


    The human hand has been a fascinating object of study for researchers in both biomechanics and motor control. Studies of human prehension have contributed significantly to the progress in addressing the famous problem of motor redundancy. After a brief review of the hand mechanics, we present results of recent studies that support a general view that the apparently redundant design of the hand is not a source of computational problems but a rich apparatus that allows performing a variety of tasks in a reliable and flexible way (the principle of abundance). Multi-digit synergies have been analyzed at two levels of a hypothetical hierarchy involved in the control of prehensile actions. At the upper level, forces and moments produced by the thumb and virtual finger (an imagined finger with a mechanical action equal to the combined mechanical action of all four fingers of the hand) co-vary to stabilize the gripping action and the orientation of the hand-held object. These results support the principle of superposition suggested earlier in robotics with respect to the control of artificial grippers. At the lower level of the hierarchy, forces and moments produced by individual fingers co-vary to stabilize the magnitude and direction of the force vector and the moment of force produced by the virtual finger. Adjustments to changes in task constraints (such as, for example, friction under individual digits) may be local and synergic. The latter reflect multi-digit prehension synergies and may be analyzed with the so-called chain effects: Sequences of relatively straightforward cause-effect links directly related to mechanical constraints leading to non-trivial strong co-variation between pairs of elemental variables. Analysis of grip force adjustments during motion of hand-held objects suggests that the central nervous system adjusts to gravitational and inertial loads differently. The human hand is a gold mine for researchers interested in the control of natural human


    Institute of Scientific and Technical Information of China (English)

    KANG Jian-ling; WANG Hong; YE Hua-wen


    Within the affine connection framework of Lagrangian control systems, based on the results of Sussmann on controllability of general affine control systems defined on a finite-dimensional manifold, a computable sufficient condition of configuration controllability for the simple mechanical control systems was extended to the case of systems with strictly dissipative energy terms of linear isotropic nature, and a sufficient condition of equilibrium controllability for the systems was also given, where Lagrangian is kinetic energy minus potential energy. Lie bracketting of vector fields in controllable Lie algebra, and the symmetric product associated with Levi-Civita connection show virtues in the discussion. Liouville vector field simplified the computation of controllable Lie algebra for the systems, although the terms of potential energy complicated the study of configuration controllability.

  16. Control of directional change after mechanical stimulation in Drosophila

    Directory of Open Access Journals (Sweden)

    Zhou Yating


    Full Text Available Abstract Background Proper adjustment of moving direction after external mechanical stimulation is essential for animals to avoid danger (e.g. predators, and thus is vital for survival. This process involves sensory inputs, central processing and motor outputs. Recent studies have made considerable progress in identifying mechanosensitive neurons and mechanosensation receptor proteins. Our understandings of molecular and cellular mechanisms that link mechanosensation with the changes in moving direction, however, remain limited. Results In this study, we investigate the control of movement adjustment in Drosophila. In response to gentle touch at the anterior segments, Drosophila larvae reorient and select a new direction for forward movement. The extent of change in moving direction is correlated with the intensity of tactile stimuli. Sensation of gentle touch requires chordotonal organs and class IV da neurons. Genetic analysis indicates an important role for the evolutionarily conserved immunoglobulin (Ig superfamily protein Turtle (Tutl to regulate touch-initiated directional change. Tutl is required specifically in post-mitotic neurons at larval stage after the completion of embryonic development. Circuit breaking analysis identified a small subset of Tutl-positive neurons that are involved in the adjustment of moving direction. Conclusion We identify Tutl and a small subset of CNS neurons in modulating directional change in response to gentle touch. This study presents an excellent starting point for further dissection of molecular and cellular mechanisms controlling directional adjustment after mechanical stimulation.

  17. Mechanical design and optimal control of humanoid robot (TPinokio

    Directory of Open Access Journals (Sweden)

    Teck Chew Wee


    Full Text Available The mechanical structure and the control of the locomotion of bipedal humanoid is an important and challenging domain of research in bipedal robots. Accurate models of the kinematics and dynamics of the robot are essential to achieve bipedal locomotion. Toe-foot walking produces a more natural and faster walking speed and it is even possible to perform stretch knee walking. This study presents the mechanical design of a toe-feet bipedal, TPinokio and the implementation of some optimal walking gait generation methods. The optimality in the gait trajectory is achieved by applying augmented model predictive control method and the pole-zero cancellation method, taken into consideration of a trade-off between walking speed and stability. The mechanism of the TPinokio robot is designed in modular form, so that its kinematics can be modelled accurately into a multiple point-mass system, its dynamics is modelled using the single and double mass inverted pendulum model and zero-moment-point concept. The effectiveness of the design and control technique is validated by simulation testing with the robot walking on flat surface and climbing stairs.

  18. Antenna Mechanism of Length Control of Actin Cables.

    Directory of Open Access Journals (Sweden)

    Lishibanya Mohapatra


    Full Text Available Actin cables are linear cytoskeletal structures that serve as tracks for myosin-based intracellular transport of vesicles and organelles in both yeast and mammalian cells. In a yeast cell undergoing budding, cables are in constant dynamic turnover yet some cables grow from the bud neck toward the back of the mother cell until their length roughly equals the diameter of the mother cell. This raises the question: how is the length of these cables controlled? Here we describe a novel molecular mechanism for cable length control inspired by recent experimental observations in cells. This "antenna mechanism" involves three key proteins: formins, which polymerize actin, Smy1 proteins, which bind formins and inhibit actin polymerization, and myosin motors, which deliver Smy1 to formins, leading to a length-dependent actin polymerization rate. We compute the probability distribution of cable lengths as a function of several experimentally tuneable parameters such as the formin-binding affinity of Smy1 and the concentration of myosin motors delivering Smy1. These results provide testable predictions of the antenna mechanism of actin-cable length control.

  19. Mechanical Characterization of Composites and Foams for Aerospace Applications (United States)

    Veazie, D. R.; Glinsey, C.; Webb, M. M.; Norman, M.; Meador, Michael A. (Technical Monitor)


    Experimental studies to investigate the mechanical properties of ultra-lightweight polyimide foams for space applications, compression after impact (CAI) properties for low velocity impact of sandwich composites, and aspen fiber/polypropylene composites containing an interface adhesive additive, Maleic Anhydride Grafted Polypropylene (MAPP), were performed at Clark Atlanta University. Tensile, compression, flexural, and shear modulus tests were performed on TEEK foams categorized by their densities and relative cost according to ASTM specifications. Results showed that the mechanical properties of the foams increased as a function of higher price and increasing density. The CAI properties of Nomex/phenolic honeycomb core, fiberglass/epoxy facesheet sandwich composites for two damage arrangements were compared using different levels of impact energy ranging from 0 - 452 Joules. Impact on the thin side showed slightly more retention of CAI strength at low impact levels, whereas higher residual compressive strength was observed from impact on the thick side at higher impact levels. The aspen fiber/polypropylene composites studied are composed of various percentages (by weight) of aspen fiber and polypropylene ranging from 30%-60% and 40%-100%, respectively. Results showed that the MAPP increases tensile and flexural strength, while having no significant influence on tensile and flexural modulus.

  20. Mechanical characterization of coir/palmyra waste fiber hybrid composites (United States)

    Arumugaprabu, V.; Uthayakumar, M.; Cardona, F.; Sultan, M. T. H.


    In the present days, the utilization of palmyra fiber in automotive and aerospace applications has increased drastically due to its high strength and low weight. This research focuses on the development of composite materials using palmyra waste and coir fiber with polyester as a matrix. The mechanical properties such as tensile, flexural and impact strength of composites were investigated. Palmyra waste fiber and coir fiber with relative varying weight percentage in the ratio of 50:50, 40:60, 30:70 and 20:80 had been considered for the study. The composites were prepared by the compression moulding method. In addition, the prepared composites were subjected to moisture studies for 24 hours, 48 hours and 72 hours to know the composite resistance to water absorption. The results showed an increase in all the mechanical properties from the addition of palmyra waste. After analysing the results obtained from the study, a suitable application in the automobile and aerospace industries is suggested for the new developed composite.

  1. Simultaneous spectrophotometric and mechanical property characterization of skin (United States)

    Bunegin, Leonid; Moore, Jeffery B.


    Both reflectance spectroscopy and the determination Young's Modulus of skin have shown promise for identifying skin pathology. At present, these determinations are carried out using separate methodologies. This study demonstrates a new technology combining digital UV/VIS reflectance spectroscopy and vacuum aspiration for simultaneously determining the reflectance spectrum and mechanical properties of human skin tissue. A small hand held prototype device incorporating fiber-optic light guides into a vacuum channel was calibrated using various elastic materials subjected to increments of stress by vacuum from 0 to 25 in Hg. The intensity of a UV/VIS light beam reflected from the material at each vacuum increment was compared to the resulting material strain. The reflected beam was also spectrophotometrically analyzed. Skin types were similarly evaluated comparing normal and scar tissue and skin of various ages and coloration. An exponential relationship between reflected beam intensity and the amount of strain resulting from vacuum increments was observed. Young's Modulus (calculated from Aoki et. al equation) and spectra from normal skin and scar tissue were in agreement with previously published observations. Age related decreases in skin elasticity were also demonstrated. In the reflectance spectra, oxy and deoxy-hemoglobin absorbance bands were detected, becoming significantly enhanced at increased levels of vacuum. Melanin absorbance was also easily detected and appeared to correlate with skin coloration. Since superficial skin pathologies have characteristic spectroscopic and mechanical properties, this technique may provide a promising new approach for rapid, non-invasive method for the evaluation of skin lesions.

  2. Characterizing the human postural control system using detrended fluctuation analysis (United States)

    Teresa Blázquez, M.; Anguiano, Marta; de Saavedra, Fernando Arias; Lallena, Antonio M.; Carpena, Pedro


    Detrended fluctuation analysis is used to study the behaviour of the time series of the position of the center of pressure, output from the activity of a human postural control system. The results suggest that these trajectories present a crossover in their scaling properties from persistent (for high frequencies, short-range time scale) to anti-persistent (for low frequencies, long-range time scale) behaviours. The values of the scaling exponent found for the persistent parts of the trajectories are very similar for all the cases analysed. The similarity of the results obtained for the measurements done with both eyes open and both eyes closed indicate either that the visual system may be disregarded by the postural control system, while maintaining quiet standing, or that the control mechanisms associated with each type of information (visual, vestibular and somatosensory) cannot be disentangled with this technique.

  3. Characterization of a possible uptake mechanism of selective antibacterial peptides. (United States)

    Polanco, Carlos; Samaniego, José Lino; Castañón-González, Jorge Alberto; Buhse, Thomas; Sordo, Marili Leopold


    Selective antibacterial peptides containing less than 30 amino acid residues, cationic, with amphipathic properties, have been the subject of several studies due to their active participation and beneficial effects in strengthening the immune system of all living organisms. This manuscript reports the results of a comparison between the group of selective antibacterial peptides and another group called "cell penetrating peptides". An important number of the selective antibacterial peptides are cell penetrating peptides, suggesting that their toxicity is related to their uptake mechanism. The verification of this observation also includes the adaptation of a method previously published, called Polarity index, which reproduces and confirms the action of this new set of peptides. The efficiency of this method was verified based on four different databases, yielding a high score. The verification was based exclusively on the peptides already reported in the databases which have been experimentally verified.

  4. Mechanical Characterization of Bio-Char Made Hybrid Composite

    Directory of Open Access Journals (Sweden)

    Amit pandey


    Full Text Available Material discoveries and development have always been the cause of the growth and development of a nation and the need of naturally made materials is the need of hours. Thus this paper takes you to the development of a hybrid composite made of sisal fiber with epoxy as the matrix intertwined with softwood bio-char. Softwood chip bio-char, produced by slow pyrolysis, has a porous structure improving its nutrient absorbing capacity, surface area and thus a potential substituent. Bio-char has an appreciable carbon sequestration value i.e. a carbon absorbing product. The orientation of sisal fiber are changed and studied in longitudinal and orthogonal direction indicating superiority of longitudinal fiber orientation .It also addresses the variation in mechanical characteristic (tensile flexural and impact with different constituent of the new composite and its position in material selection charts with a direction for further work.

  5. Bio-Inspired Controller for a Robot Cheetah with a Neural Mechanism Controlling Leg Muscles

    Institute of Scientific and Technical Information of China (English)

    Xin Wang; Mantian Li; Pengfei Wang; Wei Guo; Lining Sun


    The realization of a high-speed running robot is one of the most challenging problems in developing legged robots.The excellent performance of cheetahs provides inspiration for the control and mechanical design of such robots.This paper presents a three-dimensional model of a cheetah that predicts the locomotory behaviors of a running cheetah.Applying biological knowledge of the neural mechanism,we control the muscle flexion and extension during the stance phase,and control the positions of the joints in the flight phase via a PD controller to minimize complexity.The proposed control strategy is shown to achieve similar locomotion of a real cheetah.The simulation realizes good biological properties,such as the leg retraction,ground reaction force,and spring-like leg behavior.The stable bounding results show the promise of the controller in high-speed locomotion.The model can reach 2.7 m·s- 1 as the highest speed,and can accelerate from 0 to 1.5 m·s -1 in one stride cycle.A mechanical structure based on this simulation is designed to demonstrate the control approach,and the most recently developed hindlimb controlled by the proposed controller is presented in swinging-leg experiments and jump-force experiments.

  6. Dynamics and control of mechanical systems in offshore engineering

    CERN Document Server

    He, Wei; How, Bernard Voon Ee; Choo, Yoo Sang


    Dynamics and Control of Mechanical Systems in Offshore Engineering is a comprehensive treatment of marine mechanical systems (MMS) involved in processes of great importance such as oil drilling and mineral recovery. Ranging from nonlinear dynamic modeling and stability analysis of flexible riser systems, through advanced control design for an installation system with a single rigid payload attached by thrusters, to robust adaptive control for mooring systems, it is an authoritative reference on the dynamics and control of MMS. Readers will gain not only a complete picture of MMS at the system level, but also a better understanding of the technical considerations involved and solutions to problems that commonly arise from dealing with them. The text provides:                                                                                                                                 ...

  7. Moving constraints as stabilizing controls in classical mechanics

    CERN Document Server

    Bressan, A


    The paper analyzes a Lagrangian system which is controlled by directly assigning some of the coordinates as functions of time, by means of frictionless constraints. In a natural system of coordinates, the equations of motions contain terms which are linear or quadratic w.r.t.time derivatives of the control functions. After reviewing the basic equations, we explain the significance of the quadratic terms, related to geodesics orthogonal to a given foliation. We then study the problem of stabilization of the system to a given point, by means of oscillating controls. This problem is first reduced to the weak stability for a related convex-valued differential inclusion, then studied by Lyapunov functions methods. In the last sections, we illustrate the results by means of various mechanical examples.

  8. Moving Constraints as Stabilizing Controls in Classical Mechanics (United States)

    Bressan, Alberto; Rampazzo, Franco


    The paper analyzes a Lagrangian system which is controlled by directly assigning some of the coordinates as functions of time, by means of frictionless constraints. In a natural system of coordinates, the equations of motion contain terms which are linear or quadratic with respect to time derivatives of the control functions. After reviewing the basic equations, we explain the significance of the quadratic terms related to geodesics orthogonal to a given foliation. We then study the problem of stabilization of the system to a given point by means of oscillating controls. This problem is first reduced to theweak stability for a related convex-valued differential inclusion, then studied by Lyapunov functions methods. In the last sections, we illustrate the results by means of various mechanical examples.

  9. Mechanical characterization and structural assessment of biocomposites for construction (United States)

    Christian, Sarah Jane

    The objective of this dissertation is to assess whether or not two particular biocomposite materials, made from hemp fabric and cellulose acetate or polyhydroxybutyrate matrices, are capable of being used for structural and/or construction purposes within in the construction and building industry. The objective of this dissertation was addressed by conducting research to meet the following three goals: (1) to measure the basic mechanical properties of hemp/cellulose acetate and hemp/PHB biocomposites and evaluate if they suitable for use in construction applications, (2) to determine how quickly moisture diffuses into the biocomposite materials and how the moisture affects the mechanical behavior, and (3) to determine how well simple models can predict behavior of structural scale laminates in tension and flexure using biocomposite ply behavior. Compression molding was used to manufacturing the biocomposites from hemp fabric and the themoplastic matrices: cellulose acetate and polyhydroxybutyrate. Four methods for determining the fiber volume fraction were evaluated, and the dissolution method, using different solvents for each matrix type, was used to determine the fiber volume fraction for each composite plate manufactured. Both types of biocomposite were tested in tension, compression, shear, and flexure and the measured properties were compared to wood and engineered wood products to assess whether the biocomposite properties are suitable for use in the construction industry. The biocomposites were conditioned in a humid environment to determine the rate of moisture diffusion into the materials. Then saturated specimens and specimens that were saturated and then dried were tested in tension to evaluate how moisture absorption affects the mechanical behavior of the biocomposites. Finally, simple models of laminate behavior based on laminate plate theory were evaluated to determine if ply level behavior could be used to predict structural scale laminate behavior

  10. Bilingualism modulates dual mechanisms of cognitive control: Evidence from ERPs. (United States)

    Morales, Julia; Yudes, Carolina; Gómez-Ariza, Carlos J; Bajo, M Teresa


    Recent behavioral findings with the AX-Continous Performance Task (AX-CPT; Morales et al., 2013) show that bilinguals only outperform monolinguals under conditions that require the highest adjustment between monitoring (proactive) and inhibitory (reactive) control, which supports the idea that bilingualism modulates the coordination of different control mechanisms. In an ERP experiment we aimed to further investigate the role that bilingualism plays in the dynamic combination of proactive and reactive control in the AX-CPT. Our results strongly indicate that bilingualism facilitates an effective adjustment between both components of cognitive control. First, we replicated previous behavioral results. Second, ERP components indicated that bilingualism influences the conflict monitoring, response inhibition and error monitoring components of control (as indexed by the N2 and P3a elicited by the probe and the error-related negativity following incorrect responses, respectively). Thus, bilinguals exerted higher reactive control than monolinguals but only when they needed to overcome the competing cue-information. These findings join others in suggesting that a better understanding of the cognitive benefits of bilingualism may require consideration of a multi-component perspective.

  11. Probable Mechanisms of Needling Therapies for Myofascial Pain Control

    Directory of Open Access Journals (Sweden)

    Li-Wei Chou


    Full Text Available Myofascial pain syndrome (MPS has been defined as a regional pain syndrome characterized by muscle pain caused by myofascial trigger points (MTrPs clinically. MTrP is defined as the hyperirritable spot in a palpable taut band of skeletal muscle fibers. Appropriate treatment to MTrPs can effectively relieve the clinical pain of MPS. Needling therapies, such as MTrP injection, dry needling, or acupuncture (AcP can effectively eliminate pain immediately. AcP is probably the first reported technique in treating MPS patients with dry needling based on the Traditional Chinese Medicine (TCM theory. The possible mechanism of AcP analgesia were studied and published in recent decades. The analgesic effect of AcP is hypothesized to be related to immune, hormonal, and nervous systems. Compared to slow-acting hormonal system, nervous system acts in a faster manner. Given these complexities, AcP analgesia cannot be explained by any single mechanism. There are several principles for selection of acupoints based on the TCM principles: “Ah-Shi” point, proximal or remote acupoints on the meridian, and extra-meridian acupoints. Correlations between acupoints and MTrPs are discussed. Some clinical and animal studies of remote AcP for MTrPs and the possible mechanisms of remote effectiveness are reviewed and discussed.

  12. Suction based mechanical characterization of superficial facial soft tissues. (United States)

    Weickenmeier, J; Jabareen, M; Mazza, E


    The present study is aimed at a combined experimental and numerical investigation of the mechanical response of superficial facial tissues. Suction based experiments provide the location, time, and history dependent behavior of skin and SMAS (superficial musculoaponeurotic system) by means of Cutometer and Aspiration measurements. The suction method is particularly suitable for in vivo, multi-axial testing of soft biological tissue including a high repeatability in subsequent tests. The campaign comprises three measurement sites in the face, i.e. jaw, parotid, and forehead, using two different loading profiles (instantaneous loading and a linearly increasing and decreasing loading curve), multiple loading magnitudes, and cyclic loading cases to quantify history dependent behavior. In an inverse finite element analysis based on anatomically detailed models an optimized set of material parameters for the implementation of an elastic-viscoplastic material model was determined, yielding an initial shear modulus of 2.32kPa for skin and 0.05kPa for SMAS, respectively. Apex displacements at maximum instantaneous and linear loading showed significant location specificity with variations of up to 18% with respect to the facial average response while observing variations in repeated measurements in the same location of less than 12%. In summary, the proposed parameter sets for skin and SMAS are shown to provide remarkable agreement between the experimentally observed and numerically predicted tissue response under all loading conditions considered in the present study, including cyclic tests.

  13. Robust Adaptive Backstepping Control Design for a Nonlinear Hydraulic-Mechanical System

    DEFF Research Database (Denmark)

    Choux, Martin; Karimi, Hamid Reza; Hovland, Geir


    converge to zero despite the uncertainties in the system according to the Barbalat lemma. The resulting controllers are able to take into account the interval uncertainties in Coulomb friction parameters and in the internal leakage parameters in the cylinders. Two adaptation laws are obtained by using......The complex dynamics that characterize hydraulic systems make it difficult for the control design to achieve prescribed goals in an efficient manner. In this paper, we present the design and analysis of a robust nonlinear controller for a nonlinear hydraulic-mechanical (NHM) system. The system...... consists of an electrohydraulic servo valve and two hydraulic cylinders. Specifically, by considering a part of the dynamics of the NHM system as a norm-bounded uncertainty, two adaptive controllers are developed based on the backstepping technique that ensure the tracking error signals asymptotically...

  14. Design and Control of Nonlinear Mechanical Systems for Minimum Time

    Directory of Open Access Journals (Sweden)

    J.B. Cardoso


    Full Text Available This paper presents an integrated methodology for optimal design and control of nonlinear flexible mechanical systems, including minimum time problems. This formulation is implemented in an optimum design code and it is applied to the nonlinear behavior dynamic response. Damping and stiffness characteristics plus control driven forces are considered as decision variables. A conceptual separation between time variant and time invariant design parameters is presented, this way including the design space into the control space and considering the design variables as control variables not depending on time. By using time integrals through all the derivations, design and control problems are unified. In the optimization process we can use both types of variables simultaneously or by interdependent levels. For treating minimum time problems, a unit time interval is mapped onto the original time interval, then treating equally time variant and time invariant problems. The dynamic response and its sensitivity are discretized via space-time finite elements, and may be integrated either by at-once integration or step-by-step. Adjoint system approach is used to calculate the sensitivities.

  15. Design and characterization of controlled release tablet of metoprolol

    Directory of Open Access Journals (Sweden)

    Gautam Singhvi


    Full Text Available Metoprolol succinate is a selective beta-adrenergic receptor blocker useful in treatment of hypertension, angina and heart failure. The purpose of the present work was to design and evaluate controlled release matrix type tablet of Metoprolo succinate using HPMC K15M and Eudragit (RLPO and RSPO as a matrix forming agents. Effect of various polymer alone and combinations were studied in pH 1.2 buffer using USP type II paddle at 50 rpm. HPMC was used to form firm gel with Eudragit polymer. Formulation with Equal proportion (1:1 of Eudragit RSPO and RLPO showed optimum drug release t50 =7 hrs and t100 =16 hrs indicate optimum permeability for drug release from matrix. The drug release mechanism was predominantly found to be Non-Fickian diffusion controlled.

  16. Underwater characterization of control rods for waste disposal using SMOPY

    Energy Technology Data Exchange (ETDEWEB)

    Gallozzi-Ulmann, A.; Couturier, P.; Amgarou, K.; Rothan, D.; Menaa, N. [CANBERRA France,1 rue des Herons, 78182 ST Quentin Yvelines Cedex (France); Chard, P. [CANBERRA UK, Lower Dunbeath House, Forss Business Park, Thurso, Caithness KW14 7UZ (United Kingdom)


    Storage of spent fuel assemblies in cooling ponds requires careful control of the geometry and proximity of adjacent assemblies. Measurement of the fuel burnup makes it possible to optimise the storage arrangement of assemblies taking into account the effect of the burnup on the criticality safety margins ('burnup credit'). Canberra has developed a measurement system for underwater measurement of spent fuel assemblies. This system, known as 'SMOPY', performs burnup measurements based on gamma spectroscopy (collimated CZT detector) and neutron counting (fission chamber). The SMOPY system offers a robust and waterproof detection system as well as the needed capability of performing radiometric measurements in the harsh high dose - rate environments of the cooling ponds. The gamma spectroscopy functionality allows powerful characterization measurements to be performed, in addition to burnup measurement. Canberra has recently performed waste characterisation measurements at a Nuclear Power Plant. Waste activity assessment is important to control costs and risks of shipment and storage, to ensure that the activity level remains in the range allowed by the facility, and to declare activity data to authorities. This paper describes the methodology used for the SMOPY measurements and some preliminary results of a radiological characterisation of AIC control rods. After describing the features and normal operation of the SMOPY system, we describe the approach used for establishing an optimum control rod geometric scanning approach (optimum count time and speed) and the method of the gamma spectrometry measurements as well as neutron check measurements used to verify the absence of neutron sources in the waste. We discuss the results obtained including {sup 60}Co, {sup 110m}Ag and {sup 108m}Ag activity profiles (along the length of the control rods) and neutron results including Total Measurement Uncertainty evaluations. Full self-consistency checks were

  17. Modeling Human Error Mechanism for Soft Control in Advanced Control Rooms (ACRs)

    Energy Technology Data Exchange (ETDEWEB)

    Aljneibi, Hanan Salah Ali [Khalifa Univ., Abu Dhabi (United Arab Emirates); Ha, Jun Su; Kang, Seongkeun; Seong, Poong Hyun [KAIST, Daejeon (Korea, Republic of)


    To achieve the switch from conventional analog-based design to digital design in ACRs, a large number of manual operating controls and switches have to be replaced by a few common multi-function devices which is called soft control system. The soft controls in APR-1400 ACRs are classified into safety-grade and non-safety-grade soft controls; each was designed using different and independent input devices in ACRs. The operations using soft controls require operators to perform new tasks which were not necessary in conventional controls such as navigating computerized displays to monitor plant information and control devices. These kinds of computerized displays and soft controls may make operations more convenient but they might cause new types of human error. In this study the human error mechanism during the soft controls is studied and modeled to be used for analysis and enhancement of human performance (or human errors) during NPP operation. The developed model would contribute to a lot of applications to improve human performance (or reduce human errors), HMI designs, and operators' training program in ACRs. The developed model of human error mechanism for the soft control is based on assumptions that a human operator has certain amount of capacity in cognitive resources and if resources required by operating tasks are greater than resources invested by the operator, human error (or poor human performance) is likely to occur (especially in 'slip'); good HMI (Human-machine Interface) design decreases the required resources; operator's skillfulness decreases the required resources; and high vigilance increases the invested resources. In this study the human error mechanism during the soft controls is studied and modeled to be used for analysis and enhancement of human performance (or reduction of human errors) during NPP operation.

  18. Control of forced vibrations of mechanical structures by an electromagnetic controller with a permanent magnet

    DEFF Research Database (Denmark)

    Stein, George Juraj; Darula, Radoslav; Sorokin, Sergey


    A theoretical analysis of an electromagnetic vibration controller is presented. The analyzed device consists of a pot-type iron core with a coil and a permanent magnet as a source of constant magnetic flux. The magnetic circuit is closed by a yoke, excited by an external harmonic mechanical force....... Due to the hysteretic effects in the magnetic material the internal losses influence the overall system’s performance. A mathematical model of the force balance in the oscillatory system is derived in a simplified, linearised form. The electric as well as mechanical system is modelled using lumped......-parameter approach and the actuating principle for control of forced vibration is investigated....

  19. Optimum design of control system in recoil mechanisms

    Directory of Open Access Journals (Sweden)

    J. P. Sirpal


    Full Text Available The various parameters in the design of a control system in a conventional type of recoil mechanism have been optimized for minimum weight and the ideal form of velocity space variation during runout has been derived. A theoretical analysis for some of the equipments in service reveals that their actual values are very nearly the same as those given by theory except for the ratio l by di which are lower than those theoretically suggested indicating that wide margins of safety against buckling have been used in their design.

  20. Rhizobacterial characterization for quality control of eucalyptus biogrowth promoter products

    Directory of Open Access Journals (Sweden)

    Talyta Galafassi Zarpelon

    Full Text Available Abstract Plant growth-promoting rhizobacteria strains from special formulations have been used to optimize eucalyptus cutting production. To undertake quality control for the formulated products, the rhizobacterial strains should be characterized to assess their purity and authentication. In the present study, we characterized nine strains of rhizobacteria, including three Bacillus subtilis (S1, S2 and 3918, two Pseudomonas sp. (MF4 and FL2, P. putida (MF2, P. fulva (Ca, Frateuria aurantia (R1, and Stenotrophomonas maltophilia (CIIb. The strains were differentiated by colony morphology after 24 h of incubation in three different solid state culture media (glucose-nutritive agar, 523 medium and yeast extract-mannitol agar, sensitivity to a panel of 28 antibiotics (expressed according to the formation of inhibition halos of bacterial growth in the presence of antibiotics, and PCR-RFLP profiles of the 16S rDNA gene produced using nine restriction enzymes. It was possible to differentiate all nine strains of rhizobacteria using their morphological characteristics and sensitivity to antibiotics. The molecular analysis allowed us to separate the strains CIIb, FL2 and R1 from the strains belonging to the genera Bacillus and Pseudomonas. By using these three methods concomitantly, we were able to determine strain purity and perform the authentication.

  1. Chitosan Hydrogels for Chondroitin Sulphate Controlled Release: An Analytical Characterization

    Directory of Open Access Journals (Sweden)

    Annalisa Bianchera


    Full Text Available This paper provides an analytical characterization of chitosan scaffolds obtained by freeze-gelation toward the uptake and the controlled release of chondroitin sulphate (CS, as cartilage repair agent, under different pH conditions. Scanning electron microscopy (SEM, attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR, and liquid chromatography-UV spectrophotometry (LC-UV techniques were exploited to obtain qualitative and quantitative descriptions of polymer and drug behaviour in the biomaterial. As for morphology, SEM analysis allowed the evaluation of scaffold porosity in terms of pore size and distribution both at the surface (Feret diameter 58±19 μm and on the cross section (Feret diameter 106±51 μm. LC and ATR-FTIR evidenced a pH-dependent CS loading and release behaviour, strongly highlighting the role of electrostatic forces on chitosan/chondroitin sulphate interactions.

  2. Control of mechanical systems with rolling constraints: Application to dynamic control of mobile robots (United States)

    Sarkar, Nilanjan; Yun, Xiaoping; Kumar, Vijay


    There are many examples of mechanical systems that require rolling contacts between two or more rigid bodies. Rolling contacts engender nonholonomic constraints in an otherwise holonomic system. In this article, we develop a unified approach to the control of mechanical systems subject to both holonomic and nonholonomic constraints. We first present a state space realization of a constrained system. We then discuss the input-output linearization and zero dynamics of the system. This approach is applied to the dynamic control of mobile robots. Two types of control algorithms for mobile robots are investigated: trajectory tracking and path following. In each case, a smooth nonlinear feedback is obtained to achieve asymptotic input-output stability and Lagrange stability of the overall system. Simulation results are presented to demonstrate the effectiveness of the control algorithms and to compare the performane of trajectory-tracking and path-following algorithms.

  3. Strain-controlled criticality governs the nonlinear mechanics of fibre networks (United States)

    Sharma, A.; Licup, A. J.; Jansen, K. A.; Rens, R.; Sheinman, M.; Koenderink, G. H.; Mackintosh, F. C.


    Disordered fibrous networks are ubiquitous in nature as major structural components of living cells and tissues. The mechanical stability of networks generally depends on the degree of connectivity: only when the average number of connections between nodes exceeds the isostatic threshold are networks stable. On increasing the connectivity through this point, such networks undergo a mechanical phase transition from a floppy to a rigid phase. However, even sub-isostatic networks become rigid when subjected to sufficiently large deformations. To study this strain-controlled transition, we perform a combination of computational modelling of fibre networks and experiments on networks of type I collagen fibres, which are crucial for the integrity of biological tissues. We show theoretically that the development of rigidity is characterized by a strain-controlled continuous phase transition with signatures of criticality. Our experiments demonstrate mechanical properties consistent with our model, including the predicted critical exponents. We show that the nonlinear mechanics of collagen networks can be quantitatively captured by the predictions of scaling theory for the strain-controlled critical behaviour over a wide range of network concentrations and strains up to failure of the material.

  4. Dispersion of halloysite loaded with natural antimicrobials into pectins: Characterization and controlled release analysis. (United States)

    Gorrasi, Giuliana


    This paper reports the preparation and characterization of green composites based on pectins and nano-hybrids composed of halloysite nanotubes (HNTs) loaded with rosemary essential oil. Different hybrid percentages were mixed into a pectin matrix, by ball milling in the presence of water. Cast films were obtained and analyzed. Structural organization and physical properties (thermal, mechanical, barrier to water vapor) were correlated to the nano-hybrid content. A preliminary study on the kinetics of release of the rosmarinic acid, chosen as a model molecule, was also performed. This work showed the potential of these systems in the active packaging field where controlled release of active species is required.

  5. Vacuum Nuller Testbed Performance, Characterization and Null Control (United States)

    Lyon, R. G.; Clampin, M.; Petrone, P.; Mallik, U.; Madison, T.; Bolcar, M.; Noecker, C.; Kendrick, S.; Helmbrecht, M. A.


    The Visible Nulling Coronagraph (VNC) can detect and characterize exoplanets with filled, segmented and sparse aperture telescopes, thereby spanning the choice of future internal coronagraph exoplanet missions. NASA/Goddard Space Flight Center (GSFC) has developed a Vacuum Nuller Testbed (VNT) to advance this approach, and assess and advance technologies needed to realize a VNC as a flight instrument. The VNT is an ultra-stable testbed operating at 15 Hz in vacuum. It consists of a MachZehnder nulling interferometer; modified with a "W" configuration to accommodate a hexpacked MEMS based deformable mirror (DM), coherent fiber bundle and achromatic phase shifters. The 2-output channels are imaged with a vacuum photon counting camera and conventional camera. Error-sensing and feedback to DM and delay line with control algorithms are implemented in a real-time architecture. The inherent advantage of the VNC is that it is its own interferometer and directly controls its errors by exploiting images from bright and dark channels simultaneously. Conservation of energy requires the sum total of the photon counts be conserved independent of the VNC state. Thus sensing and control bandwidth is limited by the target stars throughput, with the net effect that the higher bandwidth offloads stressing stability tolerances within the telescope. We report our recent progress with the VNT towards achieving an incremental sequence of contrast milestones of 10(exp 8) , 10(exp 9) and 10(exp 10) respectively at inner working angles approaching 2A/D. Discussed will be the optics, lab results, technologies, and null control. Shown will be evidence that the milestones have been achieved.

  6. System identification of closed-loop cardiovascular control mechanisms: diabetic autonomic neuropathy (United States)

    Mukkamala, R.; Mathias, J. M.; Mullen, T. J.; Cohen, R. J.; Freeman, R.


    We applied cardiovascular system identification (CSI) to characterize closed-loop cardiovascular regulation in patients with diabetic autonomic neuropathy (DAN). The CSI method quantitatively analyzes beat-to-beat fluctuations in noninvasively measured heart rate, arterial blood pressure (ABP), and instantaneous lung volume (ILV) to characterize four physiological coupling mechanisms, two of which are autonomically mediated (the heart rate baroreflex and the coupling of respiration, measured in terms of ILV, to heart rate) and two of which are mechanically mediated (the coupling of ventricular contraction to the generation of the ABP wavelet and the coupling of respiration to ABP). We studied 37 control and 60 diabetic subjects who were classified as having minimal, moderate, or severe DAN on the basis of standard autonomic tests. The autonomically mediated couplings progressively decreased with increasing severity of DAN, whereas the mechanically mediated couplings were essentially unchanged. CSI identified differences between the minimal DAN and control groups, which were indistinguishable based on the standard autonomic tests. CSI may provide a powerful tool for assessing DAN.

  7. Low-Level RF Control of Spallation Neutron Source: System and Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Hengjie [ORNL


    The low-level RF control system currently commissioned throughout the Spallation Neutron Source (SNS) LINAC evolved from three design iterations over one year intensive research and development. Its digital hardware implementation is efficient, and has succeeded in achieving a minimum latency of less than 150 ns which is the key for accomplishing an all digital feedback control for the full bandwidth. The control bandwidth is analyzed in frequency domain and characterized by testing its transient response. The hardware implementation also includes the provision of a time-shared input channel for a superior phase differential measurement between the cavity field and the reference. A companion co-simulation system for the digital hardware was developed to ensure a reliable long-term supportability. A large effort has also been made in the operation software development for the practical issues such as the process automations, cavity filling, beam loading compensation, and the cavity mechanical resonance suppression.

  8. The Response Clamp: Functional characterization of neural systems using closed-loop control

    Directory of Open Access Journals (Sweden)

    Avner eWallach


    Full Text Available The voltage clamp method, pioneered by Hodgkin, Huxley and Katz, laid the foundations to neurophysiological research. Its core rationale is the use of closed-loop control as a tool for system characterization. A recently introduced method, the response clamp, extends the voltage clamp rationale to the functional, phenomenological level. The method consists of on-line estimation of a response variable of interest (e.g. the probability of response or its latency and a simple feedback control mechanism designed to tightly converge this variable towards a desired trajectory. In the present contribution I offer a perspective on this novel method and its applications in the broader context of system identification and characterization. First, I demonstrate how internal state variables are exposed using the method, and how the use of several controllers may allow for a detailed, multi-variable characterization of the system. Second, I discuss three different categories of applications of the method: (i exploration of intrinsically generated dynamics, (ii exploration of extrinsically generated dynamics and (iii generation of input-output trajectories. The relation of these categories to similar uses in the voltage clamp and other techniques is also discussed. Finally, I discuss the method’s limitations, as well as its possible synthesis with existing complementary approaches.

  9. Neural mechanisms of attentional control in mindfulness meditation

    Directory of Open Access Journals (Sweden)

    Peter eMalinowski


    Full Text Available The scientific interest in meditation and mindfulness practice has recently seen an unprecedented surge. After an initial phase of presenting beneficial effects of mindfulness practice in various domains, research is now seeking to unravel the underlying psychological and neurophysiological mechanisms. Advances in understanding these processes are required for improving and fine-tuning mindfulness-based interventions that target specific conditions such as eating disorders or attention deficit hyperactivity disorders. This review presents a theoretical framework that emphasizes the central role of attentional control mechanisms in the development of mindfulness skills. It discusses the phenomenological level of experience during meditation, the different attentional functions that are involved, and relates these to the brain networks that subserve these functions. On the basis of currently available empirical evidence specific processes as to how attention exerts its positive influence are considered and it is concluded that meditation practice appears to positively impact attentional functions by improving resource allocation processes. As a result, attentional resources are allocated more fully during early processing phases which subsequently enhance further processing. Neural changes resulting from a pure form of mindfulness practice that is central to most mindfulness programs are considered from the perspective that they constitute a useful reference point for future research. Furthermore, possible interrelations between the improvement of attentional control and emotion regulation skills are discussed.

  10. Central chemoreceptors and neural mechanisms of cardiorespiratory control

    Directory of Open Access Journals (Sweden)

    T.S. Moreira


    Full Text Available The arterial partial pressure (P CO2 of carbon dioxide is virtually constant because of the close match between the metabolic production of this gas and its excretion via breathing. Blood gas homeostasis does not rely solely on changes in lung ventilation, but also to a considerable extent on circulatory adjustments that regulate the transport of CO2 from its sites of production to the lungs. The neural mechanisms that coordinate circulatory and ventilatory changes to achieve blood gas homeostasis are the subject of this review. Emphasis will be placed on the control of sympathetic outflow by central chemoreceptors. High levels of CO2 exert an excitatory effect on sympathetic outflow that is mediated by specialized chemoreceptors such as the neurons located in the retrotrapezoid region. In addition, high CO2 causes an aversive awareness in conscious animals, activating wake-promoting pathways such as the noradrenergic neurons. These neuronal groups, which may also be directly activated by brain acidification, have projections that contribute to the CO2-induced rise in breathing and sympathetic outflow. However, since the level of activity of the retrotrapezoid nucleus is regulated by converging inputs from wake-promoting systems, behavior-specific inputs from higher centers and by chemical drive, the main focus of the present manuscript is to review the contribution of central chemoreceptors to the control of autonomic and respiratory mechanisms.

  11. Molecular mechanisms controlling the migration of striatal interneurons. (United States)

    Villar-Cerviño, Verona; Kappeler, Caroline; Nóbrega-Pereira, Sandrina; Henkemeyer, Mark; Rago, Luciano; Nieto, M Angela; Marín, Oscar


    In the developing telencephalon, the medial ganglionic eminence (MGE) generates many cortical and virtually all striatal interneurons. While the molecular mechanisms controlling the migration of interneurons to the cortex have been extensively studied, very little is known about the nature of the signals that guide interneurons to the striatum. Here we report that the allocation of MGE-derived interneurons in the developing striatum of the mouse relies on a combination of chemoattractive and chemorepulsive activities. Specifically, interneurons migrate toward the striatum in response to Nrg1/ErbB4 chemoattraction, and avoid migrating into the adjacent cortical territories by a repulsive activity mediated by EphB/ephrinB signaling. Our results also suggest that the responsiveness of MGE-derived striatal interneurons to these cues is at least in part controlled by the postmitotic activity of the transcription factor Nkx2-1. This study therefore reveals parallel mechanisms for the migration of MGE-derived interneurons to the striatum and the cerebral cortex.

  12. Emergent patterns of growth controlled by multicellular form and mechanics (United States)

    Nelson, Celeste M.; Jean, Ronald P.; Tan, John L.; Liu, Wendy F.; Sniadecki, Nathan J.; Spector, Alexander A.; Chen, Christopher S.


    Spatial patterns of cellular growth generate mechanical stresses that help to push, fold, expand, and deform tissues into their specific forms. Genetic factors are thought to specify patterns of growth and other behaviors to drive morphogenesis. Here, we show that tissue form itself can feed back to regulate patterns of proliferation. Using microfabrication to control the organization of sheets of cells, we demonstrated the emergence of stable patterns of proliferative foci. Regions of concentrated growth corresponded to regions of high tractional stress generated within the sheet, as predicted by a finite-element model of multicellular mechanics and measured directly by using a micromechanical force sensor array. Inhibiting actomyosin-based tension or cadherin-mediated connections between cells disrupted the spatial pattern of proliferation. These findings demonstrate the existence of patterns of mechanical forces that originate from the contraction of cells, emerge from their multicellular organization, and result in patterns of growth. Thus, tissue form is not only a consequence but also an active regulator of tissue growth. PMID:16049098

  13. Fixed and flexible formularies as cost-control mechanisms. (United States)

    Dewa, Carolyn S; Hoch, Jeffrey S


    The purpose of this review is to consider the prevalent types of fixed and flexible formularies, the general economic principles on which they are based and the evidence for their effectiveness in controlling rising drug expenditures. The principal-agent relationship and economic model underlying the various types of formularies are described. The principal-agent model describes a relationship where there is an asymmetry of information between two parties involved in a particular task. As a result of this asymmetry of information, the party with less information (the principal) allows the party with more information (the agent) to make decisions about that task or activity for them. In the case of formularies and cost-control, the principal is the payer. Depending on the incentives offered by the formulary, the agent can alternately be the prescriber, dispenser or patient. The success of a formulary type to control costs is dependent on two main factors. First, the payer (the principal) must identify the agent for whom it is reasonable to create incentives that incorporate the financial risks associated with use of the drugs. Second, the payer must develop a structure that best aligns the principal and agent objectives. The principal-agent framework serves as the vehicle through which the authors examine five major types of formularies (i.e., closed, best available price, reference-based pricing, tiered and open formularies) and their inherent incentives and limitations. The evidence for their effectiveness as cost-control mechanisms is reviewed and the system factors that can affect formulary success will be discussed. Finally, the authors' observations are summarized and interpreted, and suggested implications for future use of formularies in controlling the costs of pharmaceutical use are offered.

  14. A Comprehensive Review of Optical Stretcher for Cell Mechanical Characterization at Single-Cell Level

    Directory of Open Access Journals (Sweden)

    Tie Yang


    Full Text Available This paper presents a comprehensive review of the development of the optical stretcher, a powerful optofluidic device for single cell mechanical study by using optical force induced cell stretching. The different techniques and the different materials for the fabrication of the optical stretcher are first summarized. A short description of the optical-stretching mechanism is then given, highlighting the optical force calculation and the cell optical deformability characterization. Subsequently, the implementations of the optical stretcher in various cell-mechanics studies are shown on different types of cells. Afterwards, two new advancements on optical stretcher applications are also introduced: the active cell sorting based on cell mechanical characterization and the temperature effect on cell stretching measurement from laser-induced heating. Two examples of new functionalities developed with the optical stretcher are also included. Finally, the current major limitation and the future development possibilities are discussed.

  15. Multi-scale mechanical characterization of scaffolds for heart valve tissue engineering. (United States)

    Argento, G; Simonet, M; Oomens, C W J; Baaijens, F P T


    Electrospinning is a promising technology to produce scaffolds for cardiovascular tissue engineering. Each electrospun scaffold is characterized by a complex micro-scale structure that is responsible for its macroscopic mechanical behavior. In this study, we focus on the development and the validation of a computational micro-scale model that takes into account the structural features of the electrospun material, and is suitable for studying the multi-scale scaffold mechanics. We show that the computational tool developed is able to describe and predict the mechanical behavior of electrospun scaffolds characterized by different microstructures. Moreover, we explore the global mechanical properties of valve-shaped scaffolds with different microstructural features, and compare the deformation of these scaffolds when submitted to diastolic pressures with a tissue engineered and a native valve. It is shown that a pronounced degree of anisotropy is necessary to reproduce the deformation patterns observed in the native heart valve.

  16. Characterization of the mechanical properties of the SOFIA secondary mirror mechanism in a multi-stage approach (United States)

    Greiner, Benjamin; Lammen, Yannick; Reinacher, Andreas; Krabbe, Alfred; Wagner, Jörg


    The Stratospheric Observatory for Infrared Astronomy (SOFIA) uses its compact and highly integrated Secondary Mirror Mechanism (SMM) to switch between target positions on the sky in a square wave pattern. This chopping motion excites eigenmodes of the mechanism structure, which limit controller and observatory performance. We present the setup and results of experimental modal tests performed on different building stages of a test-bench model as well as on the original flight hardware. Test results were correlated to simulations employing a finite element model in order to identify excited mode shapes and contributing flexible components of the Secondary Mirror Mechanism. It was possible to isolate the motion of the compensation ring and its elastic mounts as the vibration mode inducing the main disturbance at about 300 Hz, which is currently the main mode shape limiting the performance of the chopping controller.

  17. The inner-city Skater Facility - playground or control mechanism?

    DEFF Research Database (Denmark)

    Gravesen, David Thore


    The inner-city Skater Facility - playground or control mechanism? In 2013, the municipality in Horsens, a medium-sized provincial town in Denmark, bestowed the city's children and young people a skater facility at the city's central squares. Officially, the municipality donated the facility to give...... local children and young people an opportunity to use their leisure time stimulating their bodies, having a great time with friends and other urban dwellers. The gift is accompanied by a number of (more or less camouflaged) crime prevention- and social education agendas, carried out by the SSP (a...... special Social services, School and Police unit), that observe, mingle and socialize at the facility. The social workers affiliated with the SSP understand and define their role in contradiction to the official agenda. The social workers seek to pull the young people off the street and get them to enroll...

  18. Mechanism of anterior-posterior polarity control in planarians

    Energy Technology Data Exchange (ETDEWEB)

    Lange, C.S.; Steele, V.E.


    The substance which inhibits brain formation in the regenerating planarian Dugesia etrusca was found to be a large molecule, at least in part protein, which electrophoreses as an electronegative moiety in pH 6.8 buffer. A model is presented, based on this finding and previous studies, which proposes an electrochemical mechanism for the control of polarity and possibly for the maintenance of tissue organization in planarians. It is proposed that a bioelectric field exists and moves the electronegative brain-inhibiting substance in a posterior direction, establishing polarity. This model explains the polarity reversal experiments using external fields and many of the previously unexplained classical planarian experiments. Data are presented demonstrating the existence, magnitude, and polarity of this bioelectric field, which is not greatly altered upon decapitation, all in accord with predictions of the model.

  19. In situ and laboratory mechanical characterization of a loess sequence from Middle Belgium


    Delvoie, Simon; Charlier, Robert; Collin, Frédéric


    A 10 m thick loess (aeolian silt) layer located beside the Romont quarry (Eben-Emael, Middle Belgium) has been investigated in order to characterize the mechanical behaviour of the silty material. Cone penetration tests (CPT) have been performed with different cones (M1-type, M2-type and electric) in order to evaluate the influence of the cone on the mechanical behaviour interpretation. Concurrently, laboratory tests have been performed on undisturbed samples from core drillings. Laboratory t...

  20. Cellular and Humoral Mechanisms Involved in the Control of Tuberculosis

    Directory of Open Access Journals (Sweden)

    Joaquin Zuñiga


    Full Text Available Mycobacterium tuberculosis (Mtb infection is a major international public health problem. One-third of the world's population is thought to have latent tuberculosis, a condition where individuals are infected by the intracellular bacteria without active disease but are at risk for reactivation, if their immune system fails. Here, we discuss the role of nonspecific inflammatory responses mediated by cytokines and chemokines induced by interaction of innate receptors expressed in macrophages and dendritic cells (DCs. We also review current information regarding the importance of several cytokines including IL-17/IL-23 in the development of protective cellular and antibody-mediated protective responses against Mtb and their influence in containment of the infection. Finally, in this paper, emphasis is placed on the mechanisms of failure of Mtb control, including the immune dysregulation induced by the treatment with biological drugs in different autoimmune diseases. Further functional studies, focused on the mechanisms involved in the early host-Mtb interactions and the interplay between host innate and acquired immunity against Mtb, may be helpful to improve the understanding of protective responses in the lung and in the development of novel therapeutic and prophylactic tools in TB.

  1. Lattice Metamaterials with Mechanically Tunable Poisson's Ratio for Vibration Control (United States)

    Chen, Yanyu; Li, Tiantian; Scarpa, Fabrizio; Wang, Lifeng


    Metamaterials with artificially designed architectures are increasingly considered as new paradigmatic material systems with unusual physical properties. Here, we report a class of architected lattice metamaterials with mechanically tunable negative Poisson's ratios and vibration-mitigation capability. The proposed lattice metamaterials are built by replacing regular straight beams with sinusoidally shaped ones, which are highly stretchable under uniaxial tension. Our experimental and numerical results indicate that the proposed lattices exhibit extreme Poisson's-ratio variations between -0.7 and 0.5 over large tensile deformations up to 50%. This large variation of Poisson's-ratio values is attributed to the deformation pattern switching from bending to stretching within the sinusoidally shaped beams. The interplay between the multiscale (ligament and cell) architecture and wave propagation also enables remarkable broadband vibration-mitigation capability of the lattice metamaterials, which can be dynamically tuned by an external mechanical stimulus. The material design strategy provides insights into the development of classes of architected metamaterials with potential applications including energy absorption, tunable acoustics, vibration control, responsive devices, soft robotics, and stretchable electronics.

  2. An Effective Feedback Control Mechanism for DiffServ Architecture

    Institute of Scientific and Technical Information of China (English)

    王重钢; 隆克平; 杨健; 程时端


    As a scalable QoS (Quality of Service) architecture, DiffServ (Differentiated Service) mainly consists of two components: traffic conditioning at the edge of the DiffServ domain and simple packet forwarding inside the DiffServ domain. DiffServ has many advantages such as flexibility, scalability and simplicity. But when providing AF (Assured Forwarding)services, DiffServ has some problems such as unfairness among aggregated flows or among microflows belonging to an aggregated flow. In this paper, a feedback mechanism for AF aggregated flows is proposed to solve this problem. Simulation results show that this mechanism does improve the performance of DiffServ. First, it can improve the fairness among aggregated flows and make DiffServ more friendly toward TCP (Transmission Control Protocol) flows. Second,it can decrease the buffer requirements at the congested router and thus obtain lower delay and packet loss rate. Third, it also keeps almost the same link utility as in normal DiffServ.Finally, it is simple and easy to be implemented.

  3. Mechanisms controlling the distribution of two invasive Bromus species

    Directory of Open Access Journals (Sweden)

    Olga Bykova


    Full Text Available In order to predict future range shifts for invasive species it is important to explore their ability to acclimate to the new environment and understand physiological and reproductive constraints controlling their distribution. My dissertation studied mechanisms by which temperature may affect the distribution of two aggressive plant invaders in North America, Bromus tectorum and Bromus rubens. I first evaluated winter freezing tolerance of Bromus species and demonstrated that the mechanism explaining their distinct northern range limits is different acquisition time of freezing tolerance. While B. rubens has a slower rate of freezing acclimation that leads to intolerance of sudden, late-autumn drops in temperature below -12°C, B. tectorum rapidly hardens and so is not impacted by the sudden onset of severe late-autumn cold. In addition, the analysis of male reproductive development and seed production showed that neither species produces seed at or above 36°C, due to complete pollen sterility, which might trigger climate-mediated range contractions at B. tectorum and B. rubens southern margins. Finally, a detailed gas-exchange analysis combined with biochemical modelling demonstrated that both species acclimate to a broad range of temperatures and photosynthetic response to temperature does not explain their current range separation.

  4. Passive Flow Separation Control Mechanism Inspired by Shark Skin (United States)

    Oakley, India; Lang, Amy


    The following experimental work seeks to examine shark scales as passive flow-actuated separation control mechanisms. It is hypothesized that the actuation of these scales can in fact reduce pressure drag by inhibiting flow reversal and thereby prevent flow separation. In order to examine this mechanism at a fundamental level, three-dimensional sharkskin scales were simplified and modeled as two-dimensional flaps. To further simplify the experiment, the flaps were observed within a laminar boundary layer. The laminar boundary layer was grown over a long flat plate that was placed inside a water tunnel. A rotating cylinder was also used to induce an unsteady, increasing adverse pressure gradient, which generated a reversing flow. In order to visualize the potential actuation of the two-dimensional flaps DPIV (digital particle image velocimetry) was utilized. Three main objectives for this work included, the actuation of the two-dimensional flaps, the resistance to a reversed flow as a result of flap actuation and the prevention of flow separation. However once the experiment was conducted the flaps did not perform as previously hypothesized. The adverse pressure gradient induced by the rotating cylinder did not produce a reversing flow powerful enough to actuate the flaps. NSF REU Site Award 1358991.

  5. Nanosecond pulsed sliding dielectric barrier discharge plasma actuator for airflow control: Electrical, optical, and mechanical characteristics (United States)

    Bayoda, K. D.; Benard, N.; Moreau, E.


    Plasma actuators used for active flow control are widely studied because they could replace mechanical actuators. Industrial applications of these plasma actuators sometimes require a large surface plasma sheet in view of increasing the interaction region between the discharge and the incoming flow. Instead of using a typical two-electrode nanosecond pulsed dielectric barrier discharge for which the interaction region is limited to about 20 mm, this study proposes to characterize a nanosecond sliding discharge based on a three-electrode geometry in order to increase the extension length up to the electrode gap. This sliding discharge is compared to the typical nanosecond dielectric barrier discharge by means of electrical, optical, and mechanical diagnostics. Electrical characterization reveals that the deposited energy can be widely increased. Time-resolved Intensified Charge Coupled Device (iCCD) images of the discharge development over the dielectric surface highlight that the intensity and the propagation velocity of streamers are strongly affected by the DC voltage applied at the third electrode. Finally, qualitative and quantitative characterizations of the pressure wave due to the surrounding gas heating are proposed by means of Schlieren visualizations and high frequency pressure measurements, respectively.

  6. Biophysical response of living cells to boron nitride nanoparticles: uptake mechanism and bio-mechanical characterization

    Energy Technology Data Exchange (ETDEWEB)

    Rasel, Md. Alim Iftekhar; Li, Tong; Nguyen, Trung Dung; Singh, Sanjleena [Queensland University of Technology (QUT), School of Chemistry, Physics and Mechanical Engineering (Australia); Zhou, Yinghong; Xiao, Yin [Queensland University of Technology (QUT), Institute of Health and Biomedical Innovation (Australia); Gu, YuanTong, E-mail: [Queensland University of Technology (QUT), School of Chemistry, Physics and Mechanical Engineering (Australia)


    Boron nitride nanomaterials have attracted significant interest due to their superior chemical and physical properties. Despite these novel properties, investigation on the interaction between boron nitride nanoparticle (BN NP) and living systems has been limited. In this study, BN NP (100–250 nm) is assessed as a promising biomaterial for medical applications. The toxicity of BN NP is evaluated by assessing the cells behaviours both biologically (MTT assay, ROS detection etc.) and physically (atomic force microscopy). The uptake mechanism of BN NP is studied by analysing the alternations in cellular morphology based on cell imaging techniques. The results demonstrate in vitro cytocompatibility of BN NP with immense potential for use as an effective nanoparticle for various bio-medical applications.

  7. Biophysical response of living cells to boron nitride nanoparticles: uptake mechanism and bio-mechanical characterization (United States)

    Rasel, Md. Alim Iftekhar; Li, Tong; Nguyen, Trung Dung; Singh, Sanjleena; Zhou, Yinghong; Xiao, Yin; Gu, YuanTong


    Boron nitride nanomaterials have attracted significant interest due to their superior chemical and physical properties. Despite these novel properties, investigation on the interaction between boron nitride nanoparticle (BN NP) and living systems has been limited. In this study, BN NP (100-250 nm) is assessed as a promising biomaterial for medical applications. The toxicity of BN NP is evaluated by assessing the cells behaviours both biologically (MTT assay, ROS detection etc.) and physically (atomic force microscopy). The uptake mechanism of BN NP is studied by analysing the alternations in cellular morphology based on cell imaging techniques. The results demonstrate in vitro cytocompatibility of BN NP with immense potential for use as an effective nanoparticle for various bio-medical applications.

  8. Nanostructured ZnO films in forms of rod, plate and flower: Electrodeposition mechanisms and characterization (United States)

    Kıcır, Nur; Tüken, Tunç; Erken, Ozge; Gumus, Cebrail; Ufuktepe, Yuksel


    Uniformity and reproducibility of well-defined ZnO nanostructures are particularly important issues for fabrication and applications of these nanomaterials. In present study, we report selective morphology control during electrodeposition, by adjusting the hydroxyl generation rate and Zn(OH)2 deposition. In presence of remarkably high chloride concentration (0.3 M) and -1.0 V deposition potential, slow precipitation conditions were provided in 5 mM Zn(NO3)2 solution. By doing so, we have obtained highly ordered, vertically aligned and uniformly spaced hexagon shaped nanoplates, on ITO surface. We have also investigated the mechanism for shifting the morphology from rod/plate to flower like structure of ZnO, for better understanding the reproducibility. For this reason, the influence of various supporting electrolytes (sodium/ammonium salts of acetate) has been investigated for interpretation of the influence of OH- concentration nearby the surface. From rod to plate and flower nanostructures, X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD) analysis were realized for characterization, also the optical properties were studied.

  9. Thermo-Mechanical Characterization of Silicon Carbide-Silicon Carbide Composites at Elevated Temperatures Using a Unique Combustion Facility (United States)



  10. Shark Skin Bristling as a Passive Mechanism for Separation Control (United States)

    Wheelus, Jennifer; Lang, Amy; Jones, Emily


    The skin of fast-swimming sharks is proposed to have mechanisms to reduce drag and delay flow separation. The skin of fast-swimming and agile sharks is covered with small teeth-like denticles on the order of 0.2 mm. The shortfin mako is one of the fastest and most agile ocean predators creating the need to minimize its pressure drag by controlling flow separation. Biological studies of the shortfin mako skin have shown the passive bristling angle of their denticles to exceed 50 degrees in areas on the flank corresponding to the locations likely to experience separation first. It is proposed that reversing flow, as occurs at the onset of separation in a turbulent boundary layer, would activate denticle bristling and hinder local separation from leading to global separation over the shark. This study focuses on the denticle reaction to various reversed flow conditions using a pulsating jet. Mako shark skin was subjected to numerous reversed flow velocities to determine the bristling onset velocity. Digital Particle Image Velocimetry (DPIV) and digital video were used to determine the flow conditions and denticle behavior. The effect of reversed flow velocity on denticle bristling and its relation to separation control will be discussed. Research funded by NSF (award 0932352).

  11. Mechanical stratigraphic controls on natural fracture spacing and penetration (United States)

    McGinnis, Ronald N.; Ferrill, David A.; Morris, Alan P.; Smart, Kevin J.; Lehrmann, Daniel


    Fine-grained low permeability sedimentary rocks, such as shale and mudrock, have drawn attention as unconventional hydrocarbon reservoirs. Fracturing - both natural and induced - is extremely important for increasing permeability in otherwise low-permeability rock. We analyze natural extension fracture networks within a complete measured outcrop section of the Ernst Member of the Boquillas Formation in Big Bend National Park, west Texas. Results of bed-center, dip-parallel scanline surveys demonstrate nearly identical fracture strikes and slight variation in dip between mudrock, chalk, and limestone beds. Fracture spacing tends to increase proportional to bed thickness in limestone and chalk beds; however, dramatic differences in fracture spacing are observed in mudrock. A direct relationship is observed between fracture spacing/thickness ratio and rock competence. Vertical fracture penetrations measured from the middle of chalk and limestone beds generally extend to and often beyond bed boundaries into the vertically adjacent mudrock beds. In contrast, fractures in the mudrock beds rarely penetrate beyond the bed boundaries into the adjacent carbonate beds. Consequently, natural bed-perpendicular fracture connectivity through the mechanically layered sequence generally is poor. Fracture connectivity strongly influences permeability architecture, and fracture prediction should consider thin bed-scale control on fracture heights and the strong lithologic control on fracture spacing.

  12. Mechanical and dosimetric quality control for computer controlled radiotherapy treatment equipment. (United States)

    Thompson, A V; Lam, K L; Balter, J M; McShan, D L; Martel, M K; Weaver, T A; Fraass, B A; Ten Haken, R K


    Modern computer controlled radiotherapy treatment equipment offers the possibility of delivering complex, multiple field treatments with minimal operator intervention, thus making multiple field conformal therapy practical. Conventional quality control programs are inadequate for this new technology, so new quality control procedures are needed. A reasonably fast, sensitive, and complete daily quality control program has been developed in our clinic that includes nearly automated mechanical as well as dosimetric tests. Automated delivery of these quality control fields is performed by the control system of the MM50 racetrack microtron, directed by the CCRS sequence processor [D. L. McShan and B. A. Fraass, Proceedings of the XIth International Conference on the use of computers in Radiation Therapy, 20-24 March 1994, Manchester, U.K. (North Western Medical Physics Department, Manchester, U.K., 1994), pp. 210-211], which controls the treatment process. The mechanical tests involve multiple irradiations of a single film to check the accuracy and reproducibility of the computer controlled setup of gantry and collimator angles, table orientation, collimator jaws, and multileaf collimator shape. The dosimetric tests, which involve multiple irradiations of an array of ionization chambers in a commercial dose detector (Keithly model 90100 Tracker System) rigidly attached to the head of the treatment gantry, check the output and symmetry of the treatment unit as a function of gantry and collimator angle and other parameters. For each of the dosimetric tests, readings from the five ionization chambers are automatically read out, stored, and analyzed by the computer, along with the geometric parameters of the treatment unit for that beam.(ABSTRACT TRUNCATED AT 250 WORDS)

  13. Cell shape, cytoskeletal mechanics, and cell cycle control in angiogenesis (United States)

    Ingber, D. E.; Prusty, D.; Sun, Z.; Betensky, H.; Wang, N.


    Capillary endothelial cells can be switched between growth and differentiation by altering cell-extracellular matrix interactions and thereby, modulating cell shape. Studies were carried out to determine when cell shape exerts its growth-regulatory influence during cell cycle progression and to explore the role of cytoskeletal structure and mechanics in this control mechanism. When G0-synchronized cells were cultured in basic fibroblast growth factor (FGF)-containing defined medium on dishes coated with increasing densities of fibronectin or a synthetic integrin ligand (RGD-containing peptide), cell spreading, nuclear extension, and DNA synthesis all increased in parallel. To determine the minimum time cells must be adherent and spread on extracellular matrix (ECM) to gain entry into S phase, cells were removed with trypsin or induced to retract using cytochalasin D at different times after plating. Both approaches revealed that cells must remain extended for approximately 12-15 h and hence, most of G1, in order to enter S phase. After this restriction point was passed, normally 'anchorage-dependent' endothelial cells turned on DNA synthesis even when round and in suspension. The importance of actin-containing microfilaments in shape-dependent growth control was confirmed by culturing cells in the presence of cytochalasin D (25-1000 ng ml-1): dose-dependent inhibition of cell spreading, nuclear extension, and DNA synthesis resulted. In contrast, induction of microtubule disassembly using nocodazole had little effect on cell or nuclear spreading and only partially inhibited DNA synthesis. Interestingly, combination of nocodazole with a suboptimal dose of cytochalasin D (100 ng ml-1) resulted in potent inhibition of both spreading and growth, suggesting that microtubules are redundant structural elements which can provide critical load-bearing functions when microfilaments are partially compromised. Similar synergism between nocodazole and cytochalasin D was observed

  14. Role of the advanced microstructures characterization in modeling of mechanical properties of AHSS steels

    Energy Technology Data Exchange (ETDEWEB)

    Radwański, Krzysztof, E-mail:; Wrożyna, Andrzej, E-mail:; Kuziak, Roman, E-mail:


    Detailed knowledge of the fraction, morphology and chemical composition of phase constituents and their effect on the mechanical properties play a crucial role in understanding of the mechanisms influencing the properties of Advanced High Strength Steels (AHSS). On the other hand, the most important microstructural features of these steels are characterized by different size, starting from the nano- and ending on the microscale. Therefore, a detailed characterization of the AHSS microstructure must involve many methods capable of tracing the microstructure at different scale levels. The paper presents selected capabilities of advanced analytical techniques, in combination with conventional light optical microscopy (LOM), for quantitative characterization of the microstructure developed in AHSS steels during thermomechanical processing or continuous annealing. The material used for the investigation comprised the samples of DP steel sheet produced at the industrial scale. Special emphasis was focused on the capabilities of the Field Emission Gun Scanning Electron Microscopy (FEG SEM) combined with EBSD of microstructural characterization. The significance of accurate microstructure characterization for the modeling of mechanical properties of AHSS steels was demonstrated for the case of numerical calculation of the stress–strain curve in the standard tensile test. The work results indicate that such an engineering approach is useful for prediction of material properties.

  15. Nanomechanical characterization and molecular mechanism study of nanoparticle reinforced and cross-linked chitosan biopolymer. (United States)

    Rath, Amrita; Mathesan, Santhosh; Ghosh, Pijush


    Chitosan (CS) is a biomaterial that offers many sophisticated and innovative applications in the biomedical field owing to its excellent characteristics of biodegradability, biocompatibility and non-toxicity. However, very low mechanical properties of chitosan polymer impose restriction on its further development. Cross-linking and nanoparticle reinforcement are the two possible methods to improve the mechanical properties of chitosan films. In this research, these two methods are adopted individually by using tripolyphosphate as cross-linker and nano-hydroxyapatite as particle reinforcement. The nanomechanical characterizations under static loading conditions are performed on these modified chitosan films. It is observed that nanoparticle reinforcement provided necessary mechanical properties such as ductility and modulus. The mechanisms involved in improvement of mechanical properties due to particle reinforcement are studied by molecular dynamics (MD). Further, improvement in mechanical properties due to combination of particle reinforcement and cross-linking agent with chitosan is investigated. The stress relaxation behavior for all these types of films is characterized under dynamic loading conditions using dynamic mechanical analysis (nanoDMA) experiment. A viscoelastic solid like response is observed for all types of film with modulus relaxing by 3-6% of its initial value. A suitable generalized Maxwell model is fitted with the obtained viscoelastic response of these films. The response to nano-scratch behavior is also studied for particle reinforced composite films.

  16. Quality control and process capability assessment for injection-moulded micro mechanical parts

    DEFF Research Database (Denmark)

    Gasparin, Stefania; Tosello, Guido; Hansen, Hans Nørgaard


    Quality control of micro components is an increasing challenge. Smaller mechanical parts are characterized by smaller tolerance to be verified. This paper focuses on the dimensional verification of micro injection-moulded components selected from an industrial application. These parts are measured...... using an optical coordinate measuring machine, which guarantees fast surface scans suitable for inline quality control. The uncertainty assessment of the measurements is calculated and three analyses are carried out and discussed in order to investigate the influence parameters in optical coordinate...... metrology. The estimation of the total variability of the optical measurements and the instrument repeatability are reported; moreover, the measurement system capability is evaluated according to the measurement system capability indices Cg and Cgk....

  17. Antimicrobial agents used in the control of periodontal biofilms: effective adjuncts to mechanical plaque control?

    Directory of Open Access Journals (Sweden)

    Ricardo Palmier Teles


    Full Text Available The control of biofilm accumulation on teeth has been the cornerstone of periodontal disease prevention for decades. However, the widespread prevalence of gingivitis suggests the inefficiency of self-performed mechanical plaque control in preventing gingival inflammation. This is particularly relevant in light of recent evidence suggesting that long standing gingivitis increases the risk of loss of attachment and that prevention of gingival inflammation might reduce the prevalence of mild to moderate periodontitis. Several antimicrobials have been tested as adjuncts to mechanical plaque control in order to improve the results obtained with oral home care. Recent studies, including meta-analyses, have indicated that home care products containing chemical antimicrobials can provide gingivitis reduction beyond what can be accomplished with brushing and flossing. Particularly, formulations containing chlorhexidine, mouthrinses containing essential oils and triclosan/copolymer dentifrices have well documented clinical antiplaque and antigingivitis effects. In vivo microbiological tests have demonstrated the ability of these antimicrobial agents to penetrate the biofilm mass and to kill bacteria growing within biofilms. In addition, chemical antimicrobials can reach difficult-to-clean areas such as interproximal surfaces and can also impact the growth of biofilms on soft tissue. These agents have a positive track record of safety and their use does not seem to increase the levels of resistant species. Further, no study has been able to establish a correlation between mouthrinses containing alcohol and oral cancer. In summary, the adjunct use of chemical plaque control should be recommended to subjects with well documented difficulties in achieving proper biofilm control using only mechanical means.

  18. Antimicrobial agents used in the control of periodontal biofilms: effective adjuncts to mechanical plaque control? (United States)

    Teles, Ricardo Palmier; Teles, Flavia Rocha Fonseca


    The control of biofilm accumulation on teeth has been the cornerstone of periodontal disease prevention for decades. However, the widespread prevalence of gingivitis suggests the inefficiency of self-performed mechanical plaque control in preventing gingival inflammation. This is particularly relevant in light of recent evidence suggesting that long standing gingivitis increases the risk of loss of attachment and that prevention of gingival inflammation might reduce the prevalence of mild to moderate periodontitis. Several antimicrobials have been tested as adjuncts to mechanical plaque control in order to improve the results obtained with oral home care. Recent studies, including meta-analyses, have indicated that home care products containing chemical antimicrobials can provide gingivitis reduction beyond what can be accomplished with brushing and flossing. Particularly, formulations containing chlorhexidine, mouthrinses containing essential oils and triclosan/copolymer dentifrices have well documented clinical antiplaque and antigingivitis effects. In vivo microbiological tests have demonstrated the ability of these antimicrobial agents to penetrate the biofilm mass and to kill bacteria growing within biofilms. In addition, chemical antimicrobials can reach difficult-to-clean areas such as interproximal surfaces and can also impact the growth of biofilms on soft tissue. These agents have a positive track record of safety and their use does not seem to increase the levels of resistant species. Further, no study has been able to establish a correlation between mouthrinses containing alcohol and oral cancer. In summary, the adjunct use of chemical plaque control should be recommended to subjects with well documented difficulties in achieving proper biofilm control using only mechanical means.

  19. Parametric and mechanical characterization of linear low density polyethylene (LLDPE) using rotational moulding technology

    Indian Academy of Sciences (India)

    P L Ramkumar; D M Kulkarni; V V Chaudhari


    In this research work, extensive literature review of the rotational moulding process using linear low density polythene (LLDPE) has been carried out to summarize the present status of the characterization in order to maintain quality and reliability of the products.The present characterization of rotomoulded products using LLDPE is based on the mechanical properties which are being altered by changing process parameters. However, it is observed that in the majority of applications of the products made of LLDPE using rotational moulding technology are prone to cracking failure due to manufacturing defects at room temperature. Therefore, study of fracture characterization of the material is equally important in relation to quality and reliability. In this article, the present characterization of the rotational moulded products using different polymers is summarized in the form of review and the importance of evaluation of the fracture behaviour of rotomoulded products is emphasized.

  20. Dynamic Characterization and Interaction Control of the CBM-Motus Robot for Upper-Limb Rehabilitation

    Directory of Open Access Journals (Sweden)

    Loredana Zollo


    Full Text Available This paper presents dynamic characterization and control of an upper-limb rehabilitation machine aimed at improving robot performance in the interaction with the patient. An integrated approach between mechanics and control is the key issue of the paper for the development of a robotic machine with desirable dynamic properties. Robot inertial and acceleration properties are studied in the workspace via a graphical representation based on ellipses. Robot friction is experimentally retrieved by means of a parametric identification procedure. A current-based impedance control is developed in order to compensate for friction and enhance control performance in the interaction with the patient by means of force feedback, without increasing system inertia. To this end, servo-amplifier motor currents are monitored to provide force feedback in the interaction, thus avoiding the need for force sensors mounted at the robot end-effector. Current-based impedance control is implemented on the robot; experimental results in free space as well as in constrained space are provided.

  1. Adrenergic receptor control mechanism for growth hormone secretion. (United States)

    Blackard, W G; Heidingsfelder, S A


    The influence of catecholamines on growth hormone secretion has been difficult to establish previously, possibly because of the suppressive effect of the induced hyperglycemia on growth hormone concentrations. In this study, an adrenergic receptor control mechanism for human growth hormone (HGH) secretion was uncovered by studying the effects of alpha and beta receptor blockade on insulin-induced growth hormone elevations in volunteer subjects. Alpha adrenergic blockade with phentolamine during insulin hypoglycemia, 0.1 U/kg, inhibited growth hormon elevations to 30-50% of values in the same subjects during insulin hypoglycemia without adrenergic blockade. More complete inhibition by phentolamine could not be demonstrated at a lower dose of insulin (0.05 U/kg). Beta adrenergic blockade with propranolol during insulin hypoglycemia significantly enhanced HGH concentrations in paired experiments. The inhibiting effect of alpha adrenergic receptor blockade on HGH concentrations could not be attributed to differences in blood glucose or free fatty acid values; however, more prolonged hypoglycemia and lower plasma free fatty acid values may have been a factor in the greater HGH concentrations observed during beta blockade. In the absence of insulin induced hypoglycemia, neither alpha nor beta adrenergic receptor blockade had a detectable effect on HGH concentrations. Theophylline, an inhibitor of cyclic 3'5'-AMP phosphodiesterase activity, also failed to alter plasma HGH concentrations. These studies demonstrate a stimulatory effect of alpha receptors and a possible inhibitory effect of beta receptors on growth hormone secretion.

  2. Controlled growth mechanism of poly (3-hexylthiophene) nanowires (United States)

    Kiymaz, D.; Yagmurcukardes, M.; Tomak, A.; Sahin, H.; Senger, R. T.; Peeters, F. M.; Zareie, H. M.; Zafer, C.


    Synthesis of 1D-polymer nanowires by a self-assembly method using marginal solvents is an attractive technique. While the formation mechanism is poorly understood, this method is essential in order to control the growth of nanowires. Here we visualized the time-dependent assembly of poly (3-hexyl-thiophene-2,5-diyl) (P3HT) nanowires by atomic force microscopy and scanning tunneling microscopy. The assembly of P3HT nanowires was carried out at room temperature by mixing cyclohexanone (CHN), as a poor solvent, with polymer solution in 1,2-dichlorobenzene (DCB). Both π-π stacking and planarization, obtained at the mix volume ratio of P3HT (in DCB):CHN (10:7), were considered during the investigation. We find that the length of nanowires was determined by the ordering of polymers in the polymer repetition direction. Additionally, our density functional theory calculations revealed that the presence of DCB and CHN molecules that stabilize the structural distortions due to tail group of polymers was essential for the core-wire formation.

  3. Controlling mechanisms of moisture diffusion in convective drying of leather (United States)

    Benmakhlouf, Naima; Azzouz, Soufien; Monzó-Cabrera, Juan; Khdhira, Hechmi; ELCafsi, Afif


    Leather manufacturing involves a crucial energy-intensive drying stage in the finishing process to remove its residual moisture. It occurs several times in the tanning course. As it is the target of this paper to depict an experimental way to determine moisture diffusion in the convective drying of leather. The effective diffusion coefficient is estimated by a method derived from Fick's law and by analytic method. The effective diffusion coefficients are obtained from drying tests and the diffusivity behaviour is studied versus the controlling parameter such as the convective airflow temperature. The experiments were conducted at hot air temperatures of 40, 45, 50, 55 and 60 °C and hot air speed of 1 m/s. The hot air temperature had significant effect on the effective moisture diffusivity of the leather sample. The average effective moisture diffusivity in rosehip ranged between 5.87 × 10-11 and 14.48 × 10-11 m2/s for leather at the temperatures studied. Activation energy for convective drying was found to be 38.46 kJ/mol for leather. The obtained results fully confirm the theoretical study in which an exponentially increasing relationship between effective diffusivity and temperature is predicted. The results of this study provide a better understanding of the drying mechanisms and may lead to a series of recommendations for leather drying optimization. It opens the possibility for further investigations on the description of drying conditions.

  4. Immunosensor with fluid control mechanism for salivary cortisol analysis. (United States)

    Yamaguchi, Masaki; Matsuda, Yohei; Sasaki, Shohei; Sasaki, Makoto; Kadoma, Yoshihiro; Imai, Yoshikatsu; Niwa, Daisuke; Shetty, Vivek


    The purpose of this research is to demonstrate a new design for a cortisol immunosensor for the noninvasive and quantitative analysis of salivary cortisol. We propose a cortisol immunosensor with a fluid control mechanism which has both a vertical flow and a lateral flow. The detected current resulting from a competitive reaction between the sample cortisol and a glucose oxidase (GOD)-labeled cortisol conjugate was found to be inversely related to the concentration of cortisol in the sample solution. A calibration curve using the relative detected current showed a R(2)=0.98 and CV=14% for a range of standard cortisol solutions corresponding to the concentrations of native salivary cortisol (0.1-10 ng/ml). The measurement could be accomplished within 35 min and the cortisol immunosensor could be reused. These results show promise for realizing an on-site and easy-to-use biosensor for cortisol. Used for evaluation of human salivary cortisol levels, the cortisol immunosensor measurement corresponded closely with commercially available ELISA method (R(2)=0.92). Our results indicate the promise of the new cortisol immunosensor for noninvasive, point of care measurement of human salivary cortisol levels.

  5. Weathering controls on mechanisms of carbon storage in grassland soils

    Energy Technology Data Exchange (ETDEWEB)

    Masiello, C.A.; Chadwick, O.A.; Southon, J.; Torn, M.S.; Harden, J.W.


    On a sequence of soils developed under similar vegetation, temperature, and precipitation conditions, but with variations in mineralogical properties, we use organic carbon and 14C inventories to examine mineral protection of soil organic carbon. In these soils, 14C data indicate that the creation of slow-cycling carbon can be modeled as occurring through reaction of organic ligands with Al3+ and Fe3+ cations in the upper horizons, followed by sorption to amorphous inorganic Al compounds at depth. Only one of these processes, the chelation of Al3+ and Fe3+ by organic ligands, is linked to large carbon stocks. Organic ligands stabilized by this process traverse the soil column as dissolved organic carbon (both from surface horizons and root exudates). At our moist grassland site, this chelation and transport process is very strongly correlated with the storage and long-term stabilization of soil organic carbon. Our 14C results show that the mechanisms of organic carbon transport and storage at this site follow a classic model previously believed to only be significant in a single soil order (Spodosols), and closely related to the presence of forests. The presence of this process in the grassland Alfisol, Inceptisol, and Mollisol soils of this chronosequence suggests that this process is a more significant control on organic carbon storage than previously thought.

  6. Mechanical and structural characterizations of gamma- and alpha-alumina nanofibers

    Energy Technology Data Exchange (ETDEWEB)

    Vahtrus, Mikk; Umalas, Madis [Institute of Physics, University of Tartu, Ravila 14c, 50412 Tartu (Estonia); Polyakov, Boris [Institute of Solid State Physics, University of Latvia, Kengaraga 8, LV-1063 Riga (Latvia); Dorogin, Leonid [Institute of Physics, University of Tartu, Ravila 14c, 50412 Tartu (Estonia); ITMO University, Kronverkskiy pr., 49, 197101 Saint Petersburg (Russian Federation); Saar, Rando; Tamme, Maret; Saal, Kristjan [Institute of Physics, University of Tartu, Ravila 14c, 50412 Tartu (Estonia); Lõhmus, Rünno [Institute of Physics, University of Tartu, Ravila 14c, 50412 Tartu (Estonia); Materials Technologies Competence Centre, Riia 185b, 51014 Tartu (Estonia); Vlassov, Sergei [Institute of Physics, University of Tartu, Ravila 14c, 50412 Tartu (Estonia)


    We investigate the applicability of alumina nanofibers as a potential reinforcement material in ceramic matrix compounds by comparing the mechanical properties of individual nanofibers before and after annealing at 1400 °C. Mechanical testing is performed inside a scanning electron microscope (SEM), which enables observation in real time of the deformation and fracture of the fibers under loading, thereby providing a close-up inspection of the freshly fractured area in vacuum. Improvement of both the Young's modulus and the breaking strength for annealed nanofibers is demonstrated. Mechanical testing is supplemented with the structural characterization of the fibers before and after annealing using SEM, transmission electron microscopy and X-ray diffraction methods. - Highlights: • Mechanical properties of individual alumina nanofibers were measured using in situ SEM cantilevered beam bending technique. • Improvement of mechanical properties of the alumina fibers after annealing at 1400 °C is demonstrated. • Formation of branched structures is demonstrated and their mechanical properties are studied. • XRD and electron microscopy were used for structural characterization of untreated and annealed nanofibers.

  7. Mechanical Engineering Design Project report: Enabler control systems (United States)

    Cullen, Christian; Delvecchio, Dave; Scarborough, Alan; Havics, Andrew A.


    The Controls Group was assigned the responsibility for designing the Enabler's control system. The requirement for the design was that the control system must provide a simple user interface to control the boom articulation joints, chassis articulation joints, and the wheel drive. The system required controlling hydraulic motors on the Enabler by implementing 8-bit microprocessor boards. In addition, feedback to evaluate positions and velocities must be interfaced to provide the operator with confirmation as well as control.

  8. Characterization of human mitochondrial ferritin promoter: identification of transcription factors and evidences of epigenetic control (United States)

    Guaraldo, Michela; Santambrogio, Paolo; Rovelli, Elisabetta; di Savino, Augusta; Saglio, Giuseppe; Cittaro, Davide; Roetto, Antonella; Levi, Sonia


    Mitochondrial ferritin (FtMt) is an iron storage protein belonging to the ferritin family but, unlike the cytosolic ferritin, it has an iron-unrelated restricted tissue expression. FtMt appears to be preferentially expressed in cell types characterized by high metabolic activity and oxygen consumption, suggesting a role in protecting mitochondria from iron-dependent oxidative damage. The human gene (FTMT) is intronless and its promoter region has not been described yet. To analyze the regulatory mechanisms controlling FTMT expression, we characterized the 5‧ flanking region upstream the transcriptional starting site of FTMT by in silico enquiry of sequences conservation, DNA deletion analysis, and ChIP assay. The data revealed a minimal promoter region and identified the presence of SP1, CREB and YY1 as positive regulators, and GATA2, FoxA1 and C/EBPβ as inhibitors of the transcriptional regulation. Furthermore, the FTMT transcription is increased by acetylating and de-methylating agent treatments in K562 and HeLa cells. These treatments up-regulate FtMt expression even in fibroblasts derived from a Friedreich ataxia patient, where it might exert a beneficial effect against mitochondrial oxidative damage. The expression of FTMT appears regulated by a complex mechanism involving epigenetic events and interplay between transcription factors.

  9. Smart materials-based actuators at the micronano-scale characterization, control, and applications

    CERN Document Server


    Smart Materials-Based Actuators at the Micro/Nano-Scale: Characterization, Control, and Applications gives a state of the art of emerging techniques to the characterization and control of actuators based on smart materials working at the micro/nano scale. The book aims to characterize some commonly used structures based on piezoelectric and electroactive polymeric actuators and also focuses on various and emerging techniques employed to control them. This book also includes two of the most emerging topics and applications: nanorobotics and cells micro/nano-manipulation. This book: Provides both theoretical and experimental results Contains complete information from characterization, modeling, identification, control to final applications for researchers and engineers that would like to model, characterize, control and apply their own micro/nano-systems Discusses applications such as microrobotics and their control, design and fabrication of microsystems, microassembly and its automation, nanorobotics and thei...

  10. Characterization of the dominant structural vibration of hearing aid receivers: Towards the moderation of mechanical feedback in hearing aids (United States)

    Varanda, Brenno R.

    Presented are the results from the experimental, analytical, and computational analyses accomplished to characterize the mechanical vibration of hearing aid receivers, a key electro-acoustic component of hearing aids. The function of a receiver in a hearing aid is to provide an amplified sound signal into the ear canal. Unfortunately, as the receiver produces sound, it also undergoes vibration which can be transmitted through the hearing aid package to the microphones, resulting in undesirable feedback oscillations. To gain more knowledge and control on the source of these feedback oscillations, a dynamic rigid body model of the receiver is proposed. The rigid body model captures the essential dynamic features of the receiver. The model is represented by two hinged rigid bodies, under an equal and opposite dynamic moment load, and connected to each other by a torsional spring and damper. The mechanical coupling ratio between the two rigid bodies is proved to be acoustically independent. A method is introduced to estimate the parameters for the proposed model using experimental data. An equivalent finite element analysis model is established and tested against a known and characterized mechanical attachment. The simulated model successfully predicts the structural dynamic response showing excellent agreement between the finite element analysis and measured results.

  11. Disentangling the Impact of Control-Enhancing Mechanisms on Firm Performance

    DEFF Research Database (Denmark)

    Zattoni, Alessandro; Pedersen, Torben


    Governance scholars and investors traditionally advocate against the use of control enhancing mechanisms, i.e. mechanisms aimed at separating voting and cash flow rights. These mechanisms may, in fact, determine a deviation from the proportionality principle and may encourage large and controlling......, and (ii) the negative impact on firm performance of mechanisms aimed at enhancing control by leveraging voting power is mediated by the divergence in voting and cash flow rights....

  12. Gelation Mechanisms and Characterization of Electrochemically Generated Protein Films at Metal Interfaces (United States)

    Martin, Elizabeth J.

    Although the electrochemical behavior of metals used in orthopedic implants has been studied extensively, the material interactions with proteins during corrosion processes remains poorly understood. Some studies suggest that metal-protein interactions accelerate corrosion, while others suggest that proteins protect the material from degradation. Corrosion of implant materials is a major concern due to the metal ion release that can sometimes cause adverse local tissue reactions and ultimately, failure of the implant. The initial purpose of this research was therefore to study the corrosion behavior of CoCrMo, an alloy commonly used in hip replacements, with a quartz crystal microbalance (QCM) in physiologically relevant media. The QCM enables in situ characterization of surface changes accompanying corrosion and is sensitive to viscoelastic effects at its surface. Results of QCM studies in proteinaceous media showed film deposition on the alloy surface under electrochemical conditions that otherwise produced mass loss if proteins were not present in the electrolyte. Additional studies on pure Co, Cr, and Mo demonstrated that the protein films also form on Mo surfaces after a release of molybdate ions, suggesting that these ions are essential for film formation. The electrochemically generated protein films are reminiscent of carbonaceous films that form on implant surfaces in vivo, therefore a second goal of the research was to delineate mechanisms that cause the films to form. In the second stage of this research, electrochemical QCM tests were conducted on models of the CoCrMo system consisting of Cr electrodes in proteinaceous or polymeric media containing dissolved molybdate ions. Studies indicated that films can be generated through electrochemical processes so long as both amine functional groups and molybdate ions are present in the electrolyte solution. These results suggest that the films form due to an ionic cross-linking reaction between the positively

  13. Surface-treated commercially pure titanium for biomedical applications: Electrochemical, structural, mechanical and chemical characterizations

    Energy Technology Data Exchange (ETDEWEB)

    Ogawa, Erika S.; Matos, Adaias O.; Beline, Thamara [Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Av Limeira, 901, Piracicaba, São Paulo 13414-903 (Brazil); IBTN/Br—Institute of Biomaterials, Tribocorrosion and Nanomedicine—Brazilian Branch (Brazil); Marques, Isabella S.V. [Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Av Limeira, 901, Piracicaba, São Paulo 13414-903 (Brazil); Sukotjo, Cortino [Department of Restorative Dentistry, University of Illinois at Chicago, College of Dentistry, 801 S Paulina, Chicago, IL, USA, 60612 (United States); IBTN—Institute of Biomaterials, Tribocorrosion and Nanomedicine (United States); Mathew, Mathew T. [IBTN—Institute of Biomaterials, Tribocorrosion and Nanomedicine (United States); Department of Biomedical Sciences, University of Illinois, College of Medicine at Rockford, 1601 Parkview Avenue, Rockford, IL, USA, 61107 (United States); Rangel, Elidiane C.; Cruz, Nilson C. [IBTN/Br—Institute of Biomaterials, Tribocorrosion and Nanomedicine—Brazilian Branch (Brazil); Laboratory of Technological Plasmas, Engineering College, Univ Estadual Paulista (UNESP), Av Três de Março, 511, Sorocaba, São Paulo 18087-180 (Brazil); Mesquita, Marcelo F.; Consani, Rafael X. [Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Av Limeira, 901, Piracicaba, São Paulo 13414-903 (Brazil); and others


    Modified surfaces have improved the biological performance and biomechanical fixation of dental implants compared to machined (polished) surfaces. However, there is a lack of knowledge about the surface properties of titanium (Ti) as a function of different surface treatment. This study investigated the role of surface treatments on the electrochemical, structural, mechanical and chemical properties of commercial pure titanium (cp-Ti) under different electrolytes. Cp-Ti discs were divided into 6 groups (n = 5): machined (M—control); etched with HCl + H{sub 2}O{sub 2} (Cl), H{sub 2}SO{sub 4} + H{sub 2}O{sub 2} (S); sandblasted with Al{sub 2}O{sub 3} (Sb), Al{sub 2}O{sub 3} followed by HCl + H{sub 2}O{sub 2} (SbCl), and Al{sub 2}O{sub 3} followed by H{sub 2}SO{sub 4} + H{sub 2}O{sub 2} (SbS). Electrochemical tests were conducted in artificial saliva (pHs 3; 6.5 and 9) and simulated body fluid (SBF—pH 7.4). All surfaces were characterized before and after corrosion tests using atomic force microscopy, scanning electron microscopy, energy dispersive microscopy, X-ray diffraction, surface roughness, Vickers microhardness and surface free energy. The results indicated that Cl group exhibited the highest polarization resistance (R{sub p}) and the lowest capacitance (Q) and corrosion current density (I{sub corr}) values. Reduced corrosion stability was noted for the sandblasted groups. Acidic artificial saliva decreased the R{sub p} values of cp-Ti surfaces and produced the highest I{sub corr} values. Also, the surface treatment and corrosion process influenced the surface roughness, Vickers microhardness and surface free energy. Based on these results, it can be concluded that acid-etching treatment improved the electrochemical stability of cp-Ti and all treated surfaces behaved negatively in acidic artificial saliva. - Highlights: • Characterization of surface treatment for biomedical implants was investigated. • Sandblasting reduced the corrosion stability of cp

  14. New Ultrasonic Controller and Characterization System for Low Temperature Drying Process Intensification (United States)

    Andrés, R. R.; Blanco, A.; Acosta, V. M.; Riera, E.; Martínez, I.; Pinto, A.

    Process intensification constitutes a high interesting and promising industrial area. It aims to modify conventional processes or develop new technologies in order to reduce energy needs, increase yields and improve product quality. It has been demonstrated by this research group (CSIC) that power ultrasound have a great potential in food drying processes. The effects associated with the application of power ultrasound can enhance heat and mass transfer and may constitute a way for process intensification. The objective of this work has been the design and development of a new ultrasonic system for the power characterization of piezoelectric plate-transducers, as excitation, monitoring, analysis, control and characterization of their nonlinear response. For this purpose, the system proposes a new, efficient and economic approach that separates the effect of different parameters of the process like excitation, medium and transducer parameters and variables (voltage, current, frequency, impedance, vibration velocity, acoustic pressure and temperature) by observing the electrical, mechanical, acoustical and thermal behavior, and controlling the vibrational state.

  15. Tunable mechanical monolithic sensors for large band low frequency monitoring and characterization of sites and structures (United States)

    Barone, F.; Giordano, G.; Acernese, F.; Romano, R.


    Among the different mechanical architectures present in literature, the Watts linkage is one of the most promising ones for the implementation of a new class of mechanical accelerometers (horizontal, vertical and angular). In this paper, we present monolithic implementations of uniaxial and triaxial mechanical seismometers and accelerometers based on the UNISA Folded Pendulum mechanical configuration, optimized for low frequency characterization of sites (including underground sites) and structures as inertial sensor (seismometer). This mechanical architecture allows the design and implementation of very large band monolithic sensors (10-7Hz 102 Hz), whose sensitivities for the most common applications are defined by the noise introduced by their readouts (e.g. ¡ 10-12 m/sqrt(Hz) with classical LVDT readouts). These unique features, coupled other relevant properties like scalability, compactness, lightness, high directivity, frequency tunability (typical resonance frequencies in the band 10-1 Hz 102 Hz), very high immunity to environmental noises and low cost make this class of sensors very effective for the implementation of uniaxial (horizontal and/or vertical) and triaxial seismometers and accelerometers for ground, space and underwater applications, including UHV and cryogenics ones. Typical applications of this class of monolithic sensors are in the field of earthquake engineering, seismology, geophysics, civil engineering, characterization of sites (including underground sites), structures (e.g. buildings, bridges, historical monuments), and, in general, in all applications requiring large band-low frequency performances coupled with high sensitivities and compactness.

  16. Mechanical characterization of benign and malignant urothelial cells from voided urine (United States)

    Shojaei-Baghini, Ehsan; Zheng, Yi; Jewett, Michael A. S.; Geddie, William B.; Sun, Yu


    This study investigates whether mechanical differences exist between benign and malignant urothelial cells in voided urine. The Young's modulus of individual cells was measured using the micropipette aspiration technique. Malignant urothelial cells showed significantly lower Young's modulus values compared to benign urothelial cells. The results indicate that Young's modulus as a biomechanical marker could possibly provide additional information to conventional urinary cytology. We hope that these preliminary results could evoke attention to mechanical characterization of urine cells and spark interest in the development of biomechanical approaches to enhance non-invasive urothelial carcinoma detection.

  17. Preparation and Characterization of Chitosan/Poly(Vinyl Alcohol Blended Films: Mechanical, Thermal and Surface Investigations

    Directory of Open Access Journals (Sweden)

    Esam A. El-Hefian


    Full Text Available In this study, blends of chitosan (CS and polyvinyl alcohol (PVA (CS/PVA having various proportions were prepared and characterized by universal mechanical tester, the differential scanning calorimetry (DSC and contact angle measurements. Studying the mechanical properties of the films showed that blending improved the tensile strength, which increased with increasing PVA content up to 40% while the elongation% at break of the blends was decreased compared to that of the pure components. The obtained results of DSC suggested that some interaction between chitosan and PVA mostly took place. Static water contact angle measurements showed an improvement in the wettability of the obtained films.

  18. Characterization of Organic Solar Cell Devices and their Interfaces under Degradation: Imaging, Electrical and Mechanical Methods

    DEFF Research Database (Denmark)

    Corazza, Michael

    techniques were also employed in order to study the effect of degradation on the device structure and its interfaces. This was done by exploiting different techniques that measured different properties of the device: mechanical, imaging, and electrical. Mechanical characterization of roll-to-roll processed....... Finally, imaging of cross sections of an ITO-free roll-to-roll processed device was performed successfully using transmission electron microscopy. The cross sections were prepared both with focused-ion-beam and ultramicrotomy, which gave the possibility for effectively comparing these two techniques...... energy is one of the answers for renewable energy. In this thesis, the research has been conducted on polymer solar cells. In particular, the thesis deals with the extensive study of device lifetime, characterized with several methods: from bare benchmarking of the lifetimes, to more advanced...

  19. Characterization of an X-ray mirror mechanical bender for the European XFEL. (United States)

    Vannoni, Maurizio; Freijo Martín, Idoia; Sinn, Harald


    One of the classical devices used to tune a mirror on an X-ray optical setup is a mechanical bender. This is often designed in such a way that the mirror is held with clamps on both ends; a motor is then used to put a torque on the clamps, inducing a cylindrical shape of the mirror surface. A mechanical bender with this design was recently characterized, to bend a 950 mm-long mirror up to a radius of curvature of 10 km. The characterization was performed using a large-aperture Fizeau interferometer with an angled incidence setup. Some particular and critical effects were investigated, such as calibration, hysteresis, twisting and long-term stability.

  20. Hazards Response of Energetic Materials - Initiation Mechanisms, Experimental Characterization, and Development of Predictive Capability

    Energy Technology Data Exchange (ETDEWEB)

    Maienschein, J; Nichols III, A; Reaugh, J; McClelland, M; Hsu, P C


    We present our approach to develop a predictive capability for hazards -- thermal and non-shock impact -- response of energetic material systems based on: (A) identification of relevant processes; (B) characterization of the relevant properties; (C) application of property data to predictive models; and (D) application of the models into predictive simulation. This paper focuses on the first two elements above, while a companion paper by Nichols et al focuses on the final two elements. We outline the underlying mechanisms of hazards response and their interactions, and present our experimental work to characterize the necessary material parameters, including thermal ignition, thermal and mechanical properties, fracture/fragmentation behavior, deflagration rates, and the effect of material damage. We also describe our validation test, the Scaled Thermal Explosion Experiment. Finally, we integrate the entire collection of data into a qualitative understanding that is useful until such time as the predictive models become available.

  1. Automated Mechanical Characterization of 2-D Materials using SEM based Visual Servoing (United States)

    Zimmermann, Sören; Tiemerding, Tobias; Li, Tie; Wang, Wenrong; Wang, Yuelin; Fatikow, Sergej


    Nanorobotic techniques are well-known for characterization and processing of two-dimensional materials. However, until now, most of the proposed handling procedures required manual feedback. This article presents an automated handling approach of two-dimensional nanomaterials using a robotic setup inside a high-resolution scanning electron microscope. Applying image processing of the visual feedback provided by the electron microscope, a fully automated sequence is developed to align a robotic driven force sensor with sub-micrometer accuracy and to conduct nanoindentation measurements on a periodically perforated substrate. As an example, this automated sequence is utilized to examine the mechanical properties of a few-layer graphene membrane. The results of the mechanical characterization are compared to Raman spectroscopy data. The article discusses the advantages and restrictions of this technique and responds to further application scenarios.

  2. Adaptive Augmenting Control Flight Characterization Experiment on an F/A-18 (United States)

    VanZwieten, Tannen S.; Gilligan, Eric T.; Wall, John H.; Orr, Jeb S.; Miller, Christopher J.; Hanson, Curtis E.


    The NASA Marshall Space Flight Center (MSFC) Flight Mechanics and Analysis Division developed an Adaptive Augmenting Control (AAC) algorithm for launch vehicles that improves robustness and performance by adapting an otherwise welltuned classical control algorithm to unexpected environments or variations in vehicle dynamics. This AAC algorithm is currently part of the baseline design for the SLS Flight Control System (FCS), but prior to this series of research flights it was the only component of the autopilot design that had not been flight tested. The Space Launch System (SLS) flight software prototype, including the adaptive component, was recently tested on a piloted aircraft at Dryden Flight Research Center (DFRC) which has the capability to achieve a high level of dynamic similarity to a launch vehicle. Scenarios for the flight test campaign were designed specifically to evaluate the AAC algorithm to ensure that it is able to achieve the expected performance improvements with no adverse impacts in nominal or nearnominal scenarios. Having completed the recent series of flight characterization experiments on DFRC's F/A-18, the AAC algorithm's capability, robustness, and reproducibility, have been successfully demonstrated. Thus, the entire SLS control architecture has been successfully flight tested in a relevant environment. This has increased NASA's confidence that the autopilot design is ready to fly on the SLS Block I vehicle and will exceed the performance of previous architectures.

  3. Biochemical Mechanisms Controlling Bioreactivity of Adrenal Chromaffin Cells (United States)


    kinase activity was examined from several chromatographic media, including: DEAE cellulose, carboxymethylcellulose , heparin sepharose, cellulose...Tau. Submitted to Neuron 12/91. Hall, F., Braun, R., Mihara, K., Fung, Y., Berndt, N., Carbonaro-Hall, D. and Vulliet, P. Characterization of the... Characterization and Application of Monoclonal Antibodies to Rat Tyrosine Hydroxylase J. Neurosci. Research 23: 316-325, 1989. Hall, F. L, Mitchell, J. P., and

  4. Development of an Outdoor Temperature-Based Control Algorithm for Residential Mechanical Ventilation Control

    Energy Technology Data Exchange (ETDEWEB)

    Less, Brennan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Walker, Iain [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Tang, Yihuan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)


    Smart ventilation systems use controls to ventilate more during those periods that provide either an energy or IAQ advantage (or both) and less during periods that provide a dis advantage. Using detailed building simulations, this study addresses one of the simplest and lowest cost types of smart controllers —outdoor temperature- based control. If the outdoor temperature falls below a certain cut- off, the fan is simply turned off. T he main principle of smart ventilation used in this study is to shift ventilation from time periods with large indoor -outdoor temperature differences, to periods where these differences are smaller, and their energy impacts are expected to be less. Energy and IAQ performance are assessed relative to a base case of a continuously operated ventilation fan sized to comply with ASHRAE 62.2-2013 whole house ventilation requirements. In order to satisfy 62.2-2013, annual pollutant exposure must be equivalent between the temperature controlled and continuous fan cases. This requires ventilation to be greater than 62.2 requirements when the ventilation system operates. This is achieved by increasing the mechanical ventilation system air flow rates.

  5. Control and characterization of textured, hydrophobic ionomer surfaces (United States)

    Wang, Xueyuan

    Polymer thin films are of increasing interest in many industrial and technological applications. Superhydrophobic, self-cleaning surfaces have attracted a lot of attention for their application in self-cleaning, anti-sticking coatings, stain resistance, or anti-contamination surfaces in diverse technologies, including medical, transportation, textiles, electronics and paints. This thesis focuses on the preparation of nanometer to micrometer-size particle textured surfaces which are desirable for super water repellency. Textured surfaces consisting of nanometer to micrometer-sized lightly sulfonated polystyrene ionomer (SPS) particles were prepared by rapid evaporation of the solvent from a dilute polymer solution cast onto silica. The effect of the solvent used to spin coat the film, the molecular weight of the ionomer, and the rate of solvent evaporation were investigated. The nano-particle or micron-particle textured ionomer surfaces were prepared by either spin coating or solution casting ionomer solutions at controlled evaporation rates. The surface morphologies were consistent with a spinodal decomposition mechanism where the surface first existed as a percolated-like structure and then ripened into droplets if molecular mobility was retained for sufficient time. The SPS particles or particle aggregates were robust and resisted deformation even after annealing at 120°C for one week. The water contact angles on as-prepared surfaces were relatively low, ~ 90° since the polar groups in ionomer reduce the surface hydrophobicity. After chemical vapor deposition of 1H,1H,2H,2H-perfluorooctyltrichlorosilane, the surface contact angles increased to ~ 109° on smooth surfaces and ~140° on the textured surfaces. Water droplets stuck to these surfaces even when tilted 90 degrees. Superhydrophobic surfaces were prepared by spraying coating ionomer solutions and Chemical Vapor Deposition (CVD) of 1H,1H,2H,2H-perfluorooctyltrichlorosilane onto textured surfaces. The

  6. Matlab/simMechanics based control of four-bar passive lower-body mechanism for rehabilitation

    Directory of Open Access Journals (Sweden)

    Ashish Singla


    Full Text Available In recent times, use of wearable devices is becoming popular for providing precise ways of rehabilitation. The focus of this paper is to propose a passive lower body mechanism using a four-bar linkage, which can be actuated via the hip joint to move the other two joints at knee and ankle as well. Simulations are performed here by considering an average male human (height six feet by modelling the gait cycle in CAD software and executing the control strategy in the SimMechanics, which provides a convenient way to study without use of detailed computational mathematics. The study of the controller aspects of the passive mechanism is presented with both PD and PID controllers with auto- and manual-tuned gains. Significant reduction in actuator torques is observed with the manually-tuned PID controller over automatically-tuned PID controller with marginal degradation in the overshoot and settling time.

  7. Ultrasound Imaging Techniques for Spatiotemporal Characterization of Composition, Microstructure, and Mechanical Properties in Tissue Engineering. (United States)

    Deng, Cheri X; Hong, Xiaowei; Stegemann, Jan P


    Ultrasound techniques are increasingly being used to quantitatively characterize both native and engineered tissues. This review provides an overview and selected examples of the main techniques used in these applications. Grayscale imaging has been used to characterize extracellular matrix deposition, and quantitative ultrasound imaging based on the integrated backscatter coefficient has been applied to estimating cell concentrations and matrix morphology in tissue engineering. Spectral analysis has been employed to characterize the concentration and spatial distribution of mineral particles in a construct, as well as to monitor mineral deposition by cells over time. Ultrasound techniques have also been used to measure the mechanical properties of native and engineered tissues. Conventional ultrasound elasticity imaging and acoustic radiation force imaging have been applied to detect regions of altered stiffness within tissues. Sonorheometry and monitoring of steady-state excitation and recovery have been used to characterize viscoelastic properties of tissue using a single transducer to both deform and image the sample. Dual-mode ultrasound elastography uses separate ultrasound transducers to produce a more potent deformation force to microscale characterization of viscoelasticity of hydrogel constructs. These ultrasound-based techniques have high potential to impact the field of tissue engineering as they are further developed and their range of applications expands.

  8. Transcriptional Mechanisms Controlling miR-375 Gene Expression in the Pancreas

    Directory of Open Access Journals (Sweden)

    Tali Avnit-Sagi


    Full Text Available MicroRNAs (miRNAs are a class of small non-coding RNAs that play an important role in mediating a broad and expanding range of biological activities. miR-375 is expressed selectively in the pancreas. We have previously shown that selective expression of miR-375 in pancreatic beta cells is controlled by transcriptional mechanisms operating through a TATA box-containing promoter. Expression of miR-375 has been reported in non-beta cells within the endocrine pancreas, and indeed inactivation of miR-375 leads to perturbation in cell mass and number of both alpha and beta cells. Consistent with its expression throughout the endocrine pancreas, we now show that the promoter of the miR-375 gene shows selective activity in pancreatic endocrine alpha cells, comparable to that observed in beta cells. We previously identified a novel negative regulatory element located downstream of the miR-375 gene transcription start site. By generating luciferase reporter genes, we now show that the sequence is functional also when positioned upstream of a heterologous promoter, thus proving that the repressor effect is mediated at least in part at the level of transcription. Further characterization of the transcriptional control mechanism regulating expression of miR-375 and other pancreatic miRNAs will contribute to a better understanding of pancreas development and function.

  9. Characterization of Visual Scanning Patterns in Air Traffic Control

    Directory of Open Access Journals (Sweden)

    Sarah N. McClung


    Full Text Available Characterization of air traffic controllers’ (ATCs’ visual scanning strategies is a challenging issue due to the dynamic movement of multiple aircraft and increasing complexity of scanpaths (order of eye fixations and saccades over time. Additionally, terminologies and methods are lacking to accurately characterize the eye tracking data into simplified visual scanning strategies linguistically expressed by ATCs. As an intermediate step to automate the characterization classification process, we (1 defined and developed new concepts to systematically filter complex visual scanpaths into simpler and more manageable forms and (2 developed procedures to map visual scanpaths with linguistic inputs to reduce the human judgement bias during interrater agreement. The developed concepts and procedures were applied to investigating the visual scanpaths of expert ATCs using scenarios with different aircraft congestion levels. Furthermore, oculomotor trends were analyzed to identify the influence of aircraft congestion on scan time and number of comparisons among aircraft. The findings show that (1 the scanpaths filtered at the highest intensity led to more consistent mapping with the ATCs’ linguistic inputs, (2 the pattern classification occurrences differed between scenarios, and (3 increasing aircraft congestion caused increased scan times and aircraft pairwise comparisons. The results provide a foundation for better characterizing complex scanpaths in a dynamic task and automating the analysis process.

  10. Structural Characterization of Calcium Alginate Matrices by Means of Mechanical and Release Tests

    Directory of Open Access Journals (Sweden)

    Romano Lapasin


    Full Text Available In this paper we have concentrated on the characterization of calcium alginate hydrogels loaded with a model drug (myoglobin by means of a mechanical approach; in addition, release tests of myoglobin from alginate hydrogels were performed. At a fixed temperature, relaxation tests (mechanical study were carried out on matrices constituted by different polymer concentrations. The interpretation of the relaxation behavior of the different matrices was conducted using the generalized Maxwell model; as a result of this investigation it was possible to conclude that for polymer concentrations greater than 0.5 g/ 100 mL the matrices behaved as solid materials. In addition, it was observed that the mechanical properties of the matrices increased with polymer concentration. With regard to the release tests, the diffusion coefficient of myoglobin in the matrix in relation to polymer concentrations was determined. The mechanical and release data where then analyzed by Flory’s theory and by a modified free-volume theory, respectively, to estimate the network mesh size ξ. The comparison between the mesh sizes obtained by the two approaches showed a satisfactory agreement for polymer concentrations greater than 0.5 g/100 mL. It should be noted that the approach proposed here to determine the polymeric network meshes is absolutely general and can be advantageously applied to the characterization of other similar polymeric systems.

  11. Time-dependent mechanical behavior of human amnion: macroscopic and microscopic characterization. (United States)

    Mauri, Arabella; Perrini, Michela; Ehret, Alexander E; De Focatiis, Davide S A; Mazza, Edoardo


    Characterizing the mechanical response of the human amnion is essential to understand and to eventually prevent premature rupture of fetal membranes. In this study, a large set of macroscopic and microscopic mechanical tests have been carried out on fresh unfixed amnion to gain insight into the time-dependent material response and the underlying mechanisms. Creep and relaxation responses of amnion were characterized in macroscopic uniaxial tension, biaxial tension and inflation configurations. For the first time, these experiments were complemented by microstructural information from nonlinear laser scanning microscopy performed during in situ uniaxial relaxation tests. The amnion showed large tension reduction during relaxation and small inelastic strain accumulation in creep. The short-term relaxation response was related to a concomitant in-plane and out-of-plane contraction, and was dependent on the testing configuration. The microscopic investigation revealed a large volume reduction at the beginning, but no change of volume was measured long-term during relaxation. Tension-strain curves normalized with respect to the maximum strain were highly repeatable in all configurations and allowed the quantification of corresponding characteristic parameters. The present data indicate that dissipative behavior of human amnion is related to two mechanisms: (i) volume reduction due to water outflow (up to ∼20 s) and (ii) long-term dissipative behavior without macroscopic deformation and no systematic global reorientation of collagen fibers.

  12. A novel optical coherence tomography-based micro-indentation technique for mechanical characterization of hydrogels. (United States)

    Yang, Ying; Bagnaninchi, Pierre O; Ahearne, Mark; Wang, Ruikang K; Liu, Kuo-Kang


    Depth-sensing micro-indentation has been well recognized as a powerful tool for characterizing mechanical properties of solid materials due to its non-destructive approach. Based on the depth-sensing principle, we have developed a new indentation method combined with a high-resolution imaging technique, optical coherence tomography, which can accurately measure the deformation of hydrogels under a spherical indenter at constant force. The Hertz contact theory has been applied for quantitatively correlating the indentation force and the deformation with the mechanical properties of the materials. Young's moduli of hydrogels estimated by the new method are comparable with those measured by conventional depth-sensing micro-indentation. The advantages of this new method include its capability to characterize mechanical properties of bulk soft materials and amenability to perform creeping tests. More importantly, the measurement can be performed under sterile conditions allowing non-destructive, in situ and real-time investigations on the changes in mechanical properties of soft materials (e.g. hydrogel). This unique character can be applied for various biomechanical investigations such as monitoring reconstruction of engineered tissues.

  13. Mechanical characterization of soft viscoelastic gels via indentation and optimization-based inverse finite element analysis. (United States)

    Liu, Kaifeng; VanLandingham, Mark R; Ovaert, Timothy C


    Polymer gels are widely accepted as candidate materials for tissue engineering, drug delivery, and orthopedic load-bearing applications. In addition, their mechanical and physical properties can be tailored to meet a wide range of design requirements. For soft gels whose elastic modulus is in the kPa range, mechanical characterization by bulk mechanical testing methods presents challenges, for example, in sample preparation, fixture design, gripping, and/or load measurement accuracy. Nanoindentation, however, has advantages when characterizing the mechanical properties of soft materials. This study was aimed at investigating the application of an inverse finite element analysis technique to identify material parameters of polymer gels via nanoindentation creep testing, optimization, and finite element simulation. Nanoindentation experiments were conducted using a rigid circular flat punch, and then simulated using the commercial software ABAQUS. The optimization (error minimization) procedure was integrated in the parameter determination process using a Matlab shell program, which makes this approach readily adaptable to other test geometries and material models. The finite element results compare well with a derived analytical viscoelastic solution for a rigid circular flat punch on a Kelvin-Voigt half-space.

  14. Compound control strategy used in Electro-Mechanical Actuator (EMA) (United States)

    Fu, Yongling; Yan, Meng


    This article briefly describes the overall structure of the loading test rig; establish mathematical model of loading EMA, analyze its stability, surplus force and other properties in MATLAB; propose a compound control strategy combined speed feedback, PID and feed-forward compensation based on structure invariance principle. To verify the effectiveness of the control strategy, do a co-simulation by designing a controller based on the control strategy above in MATLAB and building the EMA model in AMESim. The results show that the compound control strategy can significantly improve dynamic tracking accuracy and reduce surplus force.

  15. Mechanical and optical characterization of tungsten oxynitride (W-O-N) nano-coatings (United States)

    Nunez, Oscar Roberto

    Aation and cation doping of transition metal oxides has recently gained attention as a viable option to design materials for application in solar energy conversion, photo-catalysis, transparent electrodes, photo-electrochemical cells, electrochromics and flat panel displays in optoelectronics. Specifically, nitrogen doped tungsten oxide (WO3) has gained much attention for its ability to facilitate optical property tuning while also demonstrating enhanced photo-catalytic and photochemical properties. The effect of nitrogen chemistry and mechanics on the optical and mechanical properties of tungsten oxynitride (W-O-N) nano-coatings is studied in detail in this work. The W-O-N coatings were deposited by direct current (DC) sputtering to a thickness of ˜100 nm and the structural, compositional, optical and mechanical properties were characterized in order to gain a deeper understanding of the effects of nitrogen incorporation and chemical composition. All the W-O-N coatings fabricated under variable nitrogen gas flow rate were amorphous. X-ray photoelectron spectroscopy (XPS) and Rutherford backscattering spectrometry (RBS) measurements revealed that nitrogen incorporation is effective only for a nitrogen gas flow rates ?9 sccm. Optical characterization using ultraviolet-visible-near infrared (UV-VIS-NIR) spectroscopy and spectroscopic ellipsometry (SE) indicate that the nitrogen incorporation induced effects on the optical parameters is significant. The band gap (Eg) values decreased from ˜2.99 eV to ˜1.89 eV indicating a transition from insulating WO3 to metallic-like W-N phase. Nano-mechanical characterization using indentation revealed a corresponding change in mechanical properties; maximum values of 4.46 GPa and 98.5 GPa were noted for hardness and Young?s modulus, respectively. The results demonstrate a clear relationship between the mechanical, physical and optical properties of amorphous W-O-N nano-coatings. The correlation presented in this thesis could

  16. Mechanical characterization of composite solid rocket propellant based on hydroxy-terminated polybutadiene

    Directory of Open Access Journals (Sweden)

    Gligorijević Nikola I.


    Full Text Available This paper presents the procedure of uniaxial mechanical characterization of composite solid rocket propellant based on hydroxy-terminated polybutadiene (HTPB, whose mechanical properties strongly depend on temperature, strain rate, natural aging and accumulated damage. A method of processing data is presented in order to determine time-temperature shift factor and master curves for tensile strength, ultimate strain and relaxation modulus, depending on reduced time. Functional dependences of these features represent an input for structural analysis of a rocket motor propellant grain. The effects of natural aging on the mechanical properties are also considered. [Projekat Ministarstva nauke Republike Srbije, br. TR 36050: Research and development of unmanned aircraft in support of traffic infrastructure monitoring

  17. Characterization of resistance mechanisms to powdery mildew (Erysiphe betae) in beet (Beta vulgaris). (United States)

    Fernández-Aparicio, Mónica; Prats, Elena; Emeran, Amero A; Rubiales, Diego


    Beet powdery mildew incited by Erysiphe betae is a serious foliar fungal disease of worldwide distribution causing losses of up to 30%. In the present work, we searched for resistance in a germplasm collection of 184 genotypes of Beta vulgaris including fodder (51 genotypes), garden (60 genotypes), leaf (51 genotypes), and sugar (22 genotypes) beet types. Resistant genotypes were identified in the four beet types under study. In addition, mechanisms underlying resistance were dissected through histological studies. These revealed different resistance mechanisms acting at different fungal developmental stages, i.e., penetration resistance, early and late cell death, or posthaustorial resistance. Most genotypes were able to hamper fungal development at several stages. The later are interesting for breeding aiming to resistance durability. Furthermore, characterization of defense mechanisms will be useful for further cellular and molecular studies to unravel the bases of resistance in this species.

  18. A simple method to characterize the electrical and mechanical properties of micro-fibers

    CERN Document Server

    Castellanos-Gomez, Andres


    A procedure to characterize the electrical and mechanical properties of micro-fibers is presented here. As the required equipment can be found in many teaching laboratories, it can be carried out by physics and mechanical/electrical engineering students. The electrical resistivity, mass density and Young's modulus of carbon micro-fibers have been determined using this procedure, obtaining values in very good agreement with the reference values. The Young's modulus has been obtained by measuring the resonance frequency of carbon fiber based cantilevers. In this way, one can avoid common approaches based on tensile or bending tests which are difficult to implement for microscale materials. Despite the simplicity of the experiments proposed here, they can be used to trigger in the students interest on the electrical and mechanical properties of microscale materials.

  19. Physical and Mechanical Characterization of Electrodeposited Nickel Nanowires -- Influence of Current Density and External Magnetic Field (United States)

    Samykano, Mahendran

    Magnetic 1-D nanostructures have received great interest due to their various applications including high-density magnetic storage, sensors, drug delivery, and NEMS/MEMS systems. Among different 1-D nanostructures, magnetic nickel (Ni) nanowires with their ferromagnetic properties are of interest in such applications due to their lower cost, and they can be consistently synthesized via electrodeposition. While physical properties are influenced by processing parameters during electrodeposition of Ni nanowires, understanding of their influence on the mechanical properties is still not available. This is primarily due to the following challenges: tediousness involved in experimental techniques for mechanical characterization at nanoscale; sophisticated and careful experimentation required to be performed with advanced microscopy systems (SEM, AFM); robust nanoscale manipulators needed to place a single nanowire within the device; and difficulty in correctly loading and obtaining data for stress-strain within high powered microscopy environments. All of these factors pose significant challenges, limiting the current state of the art in mechanical characterization to its infancy, with wide differences in characterization curves and reported properties in this field. The present research and dissertation focuses on: 1. Experimental synthesis of electrodeposited Ni nanowires at different current densities and external magnetic fields, 2. Physical properties characterization of the synthesized nanowires to understand their morphology, structural and crystallographic properties, 3. Mechanical properties characterization of synthesized Ni nanowires through careful experiments within scanning electron microscope (SEM) based on uni-axial MEMS tensile loading device, 4. Data analysis to understand the process, physical and mechanical property interrelationship and to obtain insights on tensile deformation and failure modes observed in the Ni nanowires studied. Key research

  20. Characterization and modeling of mechanical behavior of quenching and partitioning steels

    Energy Technology Data Exchange (ETDEWEB)

    Arlazarov, A., E-mail: [ArcelorMittal Global Research and Development, Voie Romaine-BP30320, 57283 Maizières-lès-Metz Cedex (France); Laboratoire d’Etude des Microstructures et de Mécanique des Matériaux (LEM3), CNRS UMR 7239, Université de Lorraine, 57012 Metz Cedex (France); Bouaziz, O. [ArcelorMittal Global Research and Development, Voie Romaine-BP30320, 57283 Maizières-lès-Metz Cedex (France); Laboratoire d’Etude des Microstructures et de Mécanique des Matériaux (LEM3), CNRS UMR 7239, Université de Lorraine, 57012 Metz Cedex (France); Masse, J.P.; Kegel, F. [ArcelorMittal Global Research and Development, Voie Romaine-BP30320, 57283 Maizières-lès-Metz Cedex (France)


    Q and P annealing was applied to cold rolled carbon–manganese steel with Si. Q and P cycles with different partitioning temperature and time were simulated and the evolution of microstructure and mechanical properties was investigated. All the microstructures were composed of three constituents: partitioned martensite, laths of retained austenite and MA islands. Fine microstructure characterization confirmed that C diffusion plays an important role for the stabilization of retained austenite at room temperature and further TRIP effect during mechanical loading. Good compromise between yield strength (∼1200 MPa) and uniform elongation (∼11%) was found in the case of 400 °C partitioning for 300 s due to the enhanced mechanical stability of retained austenite. Evolution of microstructure and mechanical properties was discussed and some mechanisms were proposed to explain the observations. Mechanical model for the prediction of stress–strain curves of Q and P steels was proposed, based on the obtained experimental data. Accurate prediction of stress–strain curves using model was achieved.

  1. Intramuscular Connective Tissue Differences in Spastic and Control Muscle: A Mechanical and Histological Study (United States)

    de Bruin, Marije; Smeulders, Mark J.; Kreulen, Michiel; Huijing, Peter A.; Jaspers, Richard T


    Cerebral palsy (CP) of the spastic type is a neurological disorder characterized by a velocity-dependent increase in tonic stretch reflexes with exaggerated tendon jerks. Secondary to the spasticity, muscle adaptation is presumed to contribute to limitations in the passive range of joint motion. However, the mechanisms underlying these limitations are unknown. Using biopsies, we compared mechanical as well as histological properties of flexor carpi ulnaris muscle (FCU) from CP patients (n = 29) and healthy controls (n = 10). The sarcomere slack length (mean 2.5 µm, SEM 0.05) and slope of the normalized sarcomere length-tension characteristics of spastic fascicle segments and single myofibre segments were not different from those of control muscle. Fibre type distribution also showed no significant differences. Fibre size was significantly smaller (1933 µm2, SEM 190) in spastic muscle than in controls (2572 µm2, SEM 322). However, our statistical analyses indicate that the latter difference is likely to be explained by age, rather than by the affliction. Quantities of endomysial and perimysial networks within biopsies of control and spastic muscle were unchanged with one exception: a significant thickening of the tertiary perimysium (3-fold), i.e. the connective tissue reinforcement of neurovascular tissues penetrating the muscle. Note that this thickening in tertiary perimysium was shown in the majority of CP patients, however a small number of patients (n = 4 out of 23) did not have this feature. These results are taken as indications that enhanced myofascial loads on FCU is one among several factors contributing in a major way to the aetiology of limitation of movement at the wrist in CP and the characteristic wrist position of such patients. PMID:24977410

  2. Intramuscular connective tissue differences in spastic and control muscle: a mechanical and histological study.

    Directory of Open Access Journals (Sweden)

    Marije de Bruin

    Full Text Available Cerebral palsy (CP of the spastic type is a neurological disorder characterized by a velocity-dependent increase in tonic stretch reflexes with exaggerated tendon jerks. Secondary to the spasticity, muscle adaptation is presumed to contribute to limitations in the passive range of joint motion. However, the mechanisms underlying these limitations are unknown. Using biopsies, we compared mechanical as well as histological properties of flexor carpi ulnaris muscle (FCU from CP patients (n = 29 and healthy controls (n = 10. The sarcomere slack length (mean 2.5 µm, SEM 0.05 and slope of the normalized sarcomere length-tension characteristics of spastic fascicle segments and single myofibre segments were not different from those of control muscle. Fibre type distribution also showed no significant differences. Fibre size was significantly smaller (1933 µm2, SEM 190 in spastic muscle than in controls (2572 µm2, SEM 322. However, our statistical analyses indicate that the latter difference is likely to be explained by age, rather than by the affliction. Quantities of endomysial and perimysial networks within biopsies of control and spastic muscle were unchanged with one exception: a significant thickening of the tertiary perimysium (3-fold, i.e. the connective tissue reinforcement of neurovascular tissues penetrating the muscle. Note that this thickening in tertiary perimysium was shown in the majority of CP patients, however a small number of patients (n = 4 out of 23 did not have this feature. These results are taken as indications that enhanced myofascial loads on FCU is one among several factors contributing in a major way to the aetiology of limitation of movement at the wrist in CP and the characteristic wrist position of such patients.

  3. Intramuscular connective tissue differences in spastic and control muscle: a mechanical and histological study. (United States)

    de Bruin, Marije; Smeulders, Mark J; Kreulen, Michiel; Huijing, Peter A; Jaspers, Richard T


    Cerebral palsy (CP) of the spastic type is a neurological disorder characterized by a velocity-dependent increase in tonic stretch reflexes with exaggerated tendon jerks. Secondary to the spasticity, muscle adaptation is presumed to contribute to limitations in the passive range of joint motion. However, the mechanisms underlying these limitations are unknown. Using biopsies, we compared mechanical as well as histological properties of flexor carpi ulnaris muscle (FCU) from CP patients (n = 29) and healthy controls (n = 10). The sarcomere slack length (mean 2.5 µm, SEM 0.05) and slope of the normalized sarcomere length-tension characteristics of spastic fascicle segments and single myofibre segments were not different from those of control muscle. Fibre type distribution also showed no significant differences. Fibre size was significantly smaller (1933 µm2, SEM 190) in spastic muscle than in controls (2572 µm2, SEM 322). However, our statistical analyses indicate that the latter difference is likely to be explained by age, rather than by the affliction. Quantities of endomysial and perimysial networks within biopsies of control and spastic muscle were unchanged with one exception: a significant thickening of the tertiary perimysium (3-fold), i.e. the connective tissue reinforcement of neurovascular tissues penetrating the muscle. Note that this thickening in tertiary perimysium was shown in the majority of CP patients, however a small number of patients (n = 4 out of 23) did not have this feature. These results are taken as indications that enhanced myofascial loads on FCU is one among several factors contributing in a major way to the aetiology of limitation of movement at the wrist in CP and the characteristic wrist position of such patients.

  4. Independent backup mode transfer and mechanism for digital control computers (United States)

    Tulpule, Bhalchandra R. (Inventor); Oscarson, Edward M. (Inventor)


    An interrupt is provided to a signal processor having a non-maskable interrupt input, in response to the detection of a request for transfer to backup software. The signal processor provides a transfer signal to a transfer mechanism only after completion of the present machine cycle. Transfer to the backup software is initiated by the transfer mechanism only upon reception of the transfer signal.

  5. Mechanical and controller design of a modular mechatronic device - mechacell


    Ristevski, Stefan


    Cataloged from PDF version of thesis. Includes bibliographical references (leaves 75-79). Thesis (M.S.): Bilkent University, The Department of Mechanical Engineering, İhsan Doğramacı Bilkent University, 2015. Since ancient times people have been building tools to aid them in their life. Robots evolved from being purely mechanical to mechatronic, from immobile to mobile and became smaller in scale. As the technology in building robots matured researchers, began working to bui...

  6. Adaptive Control Methods for Mechanical Manipulators: A Comparative Study (United States)


    control task is to what extent one should take into account real robot dynamics in control synthesis. Current industrial practices, in order to an attempt to be able to take advantage of the full robot dynamics and to overcome the limitations of the actually available practices [16,17...given to the question of how to use the knowledge of the robot dynamics to synthesize such control that would be simple enough to implement in practice

  7. Adaptive Clutch Engaging Process Control for Automatic Mechanical Transmission

    Institute of Scientific and Technical Information of China (English)

    LIU Hai-ou; CHEN Hui-yan; DING Hua-rong; HE Zhong-bo


    Based on detail analysis of clutch engaging process control targets and adaptive demands, a control strategy which is based on speed signal, different from that of based on main clutch displacement signal, is put forward. It considers both jerk and slipping work which are the most commonly used quality evaluating indexes of vehicle starting phase. The adaptive control system and its reference model are discussed profoundly.Taking the adaptability to different starting gears and different road conditions as examples, some proving field test records are shown to illustrate the main clutch adaptive control strategy at starting phase. Proving field test gives acceptable results.

  8. Prognostics Enhanced Reconfigurable Control of Electro-Mechanical Actuators (United States)

    National Aeronautics and Space Administration — Actuator systems are employed widely in aerospace, transportation and industrial processes to provide power to critical loads, such as aircraft control surfaces....

  9. Control Mechanism Strategies for Spin-Stabilized Projectiles (United States)


    from more traditional smart weapons, thus warranting basic research into guidance and control strategies. Conventional methods include canards, fins...moment arms. AACC XNXN  . (1) 14 CG CP Nose Base Figure 13. Relationship between maneuver footprint and control axial location. XC CG MC

  10. An Intelligent Call Admission Control Decision Mechanism for Wireless Networks

    CERN Document Server

    S., Ramesh Babu H; S, Satyanarayana P


    The Call admission control (CAC) is one of the Radio Resource Management (RRM) techniques plays instrumental role in ensuring the desired Quality of Service (QoS) to the users working on different applications which have diversified nature of QoS requirements. This paper proposes a fuzzy neural approach for call admission control in a multi class traffic based Next Generation Wireless Networks (NGWN). The proposed Fuzzy Neural Call Admission Control (FNCAC) scheme is an integrated CAC module that combines the linguistic control capabilities of the fuzzy logic controller and the learning capabilities of the neural networks .The model is based on Recurrent Radial Basis Function Networks (RRBFN) which have better learning and adaptability that can be used to develop the intelligent system to handle the incoming traffic in the heterogeneous network environment. The proposed FNCAC can achieve reduced call blocking probability keeping the resource utilisation at an optimal level. In the proposed algorithm we have c...

  11. Spacecraft dynamics characterization and control system failure detection, volume 1 (United States)


    The work under this grant has been directed to two aspects of the control of flexible spacecraft: (1) the modeling of deployed or erected structures including nonlinear joint characteristics; and (2) the detection and isolation of failures of the components of control systems for large space structures. The motivation for the first of these research tasks is the fact that very large assemblies in space will have to be built or deployed in situ. A likely scenario is, in fact, a combination of these wherein modules which are folded for transportation into orbit are erected to their final configuration and then jointed with other such erected modules to form the full assembly. Any such erectable modules will have joints. It remains to be seen whether or not joints designed for operational assemblies will have nonlinear properties, but it seems prudent to develop a methodology for dealing with that possibility. The motivation for the second of these research tasks is the fact that we foresee large assemblies in space which will require active control to damp vibrations and/or hold a desired shape. Lightweight structures will be very flexible, with many elastic modes having very low frequencies. In order to control these modes well, the control system will likely require many sensors and many actuators, probably distributed over much of the structure. The combination of a large number of control system components with long operational periods virtually guarantees that these systems will suffer control system component failures during operation. The control system must be designed to tolerate failures of some sensors and actuators, and still be able to continue to perform its function.

  12. Physical damping in IDA-PBC controlled underactuated mechanical systems : Special issue on Hamiltonian and Lagrangian Methods for Nonlinear Control

    NARCIS (Netherlands)

    Gómez-Estern, F.; Schaft, A.J. van der


    Energy shaping and passivity-based control designs have proven to be effective in solving control problems for underactuated mechanical systems. In recent works, Interconnection and Damping Assignment Passivity-Based Control (IDA-PBC) has been successfully applied to open loop conservative models, i

  13. Correction: β-Sialon nanowires, nanobelts and hierarchical nanostructures: morphology control, growth mechanism and cathodoluminescence properties (United States)

    Huang, Juntong; Huang, Zhaohui; Liu, Yangai; Fang, Minghao; Chen, Kai; Huang, Yaoting; Huang, Saifang; Ji, Haipeng; Yang, Jingzhou; Wu, Xiaowen; Zhang, Shaowei


    Correction for `β-Sialon nanowires, nanobelts and hierarchical nanostructures: morphology control, growth mechanism and cathodoluminescence properties' by Juntong Huang, et al., Nanoscale, 2014, 6, 424-432.

  14. Mechanical and histological characterization of the abdominal muscle. A previous step to modelling hernia surgery. (United States)

    Hernández, B; Peña, E; Pascual, G; Rodríguez, M; Calvo, B; Doblaré, M; Bellón, J M


    The aims of this study are to experimentally characterize the passive elastic behaviour of the rabbit abdominal wall and to develop a mechanical constitutive law which accurately reproduces the obtained experimental results. For this purpose, tissue samples from New Zealand White rabbits 2150±50 (g) were mechanically tested in vitro. Mechanical tests, consisting of uniaxial loading on tissue samples oriented along the craneo-caudal and the perpendicular directions, respectively, revealed the anisotropic non-linear mechanical behaviour of the abdominal tissues. Experiments were performed considering the composite muscle (including external oblique-EO, internal oblique-IO and transverse abdominis-TA muscle layers), as well as separated muscle layers (i.e., external oblique, and the bilayer formed by internal oblique and transverse abdominis). Both the EO muscle layer and the IO-TA bilayer demonstrated a stiffer behaviour along the transversal direction to muscle fibres than along the longitudinal one. The fibre arrangement was measured by means of a histological study which confirmed that collagen fibres are mainly responsible for the passive mechanical strength and stiffness. Furthermore, the degree of anisotropy of the abdominal composite muscle turned out to be less pronounced than those obtained while studying the EO and IO-TA separately. Moreover, a phenomenological constitutive law was used to capture the measured experimental curves. A Levenberg-Marquardt optimization algorithm was used to fit the model constants to reproduce the experimental curves.

  15. Fast on-wafer electrical, mechanical, and electromechanical characterization of piezoresistive cantilever force sensors (United States)

    Tosolini, G.; Villanueva, L. G.; Perez-Murano, F.; Bausells, J.


    Validation of a technological process requires an intensive characterization of the performance of the resulting devices, circuits, or systems. The technology for the fabrication of micro and nanoelectromechanical systems (MEMS and NEMS) is evolving rapidly, with new kind of device concepts for applications like sensing or harvesting are being proposed and demonstrated. However, the characterization tools and methods for these new devices are still not fully developed. Here, we present an on-wafer, highly precise, and rapid characterization method to measure the mechanical, electrical, and electromechanical properties of piezoresistive cantilevers. The setup is based on a combination of probe-card and atomic force microscopy technology, it allows accessing many devices across a wafer and it can be applied to a broad range of MEMS and NEMS. Using this setup we have characterized the performance of multiple submicron thick piezoresistive cantilever force sensors. For the best design we have obtained a force sensitivity ℜF = 158μV/nN, a noise of 5.8 μV (1 Hz-1 kHz) and a minimum detectable force of 37 pN with a relative standard deviation of σr ≈ 8%. This small value of σr, together with a high fabrication yield >95%, validates our fabrication technology. These devices are intended to be used as bio-molecular detectors for the measurement of intermolecular forces between ligand and receptor molecule pairs.

  16. Stance phase mechanical characterization of transtibial prostheses distal to the socket: A review

    Directory of Open Access Journals (Sweden)

    Matthew J. Major, PhD


    Full Text Available Achieving the required functionality of a transtibial prosthesis during the stance phase of gait (e.g., shock absorption, close to normal roll-over characteristics, and smooth transition into swing depends on the Amputee Independent Prosthesis Properties (AIPPs, defined here as the mechanical properties of the prosthesis that directly influence the performance of the amputee. Accordingly, if research studies are to advance the design of prostheses to achieve improved user performance, AIPPs must be a primary consideration. However, the majority of reported studies can be categorized as either human performance testing of commercial prosthetic components or AIPP characterization; only in a few notable cases have studies combined these two approaches. Moreover, very little consistency exists in the current methods used for AIPP characterization, thus making comparisons between the results of such studies very difficult. This article introduces a framework for studying prosthesis design, which includes AIPP characterization, human performance and/or gait simulation studies, and detailed design. This framework provides a structure for reviewing previous approaches to AIPP characterization, discussing both their merits and shortcomings and their use in previous experimental and simulation studies. For the purposes of this review, stance phase AIPP models have been categorized as either lumped parameter or roll-over shape based.

  17. Characterizing and Controlling Beam Losses at the LANSCE Facility

    Energy Technology Data Exchange (ETDEWEB)

    Rybarcyk, Lawrence J. [Los Alamos National Laboratory


    The Los Alamos Neutron Science Center (LANSCE) currently provides 100-MeV H{sup +} and 800-MeV H{sup -} beams to several user facilities that have distinct beam requirements, e.g. intensity, micropulse pattern, duty factor, etc. Minimizing beam loss is critical to achieving good performance and reliable operation, but can be challenging in the context of simultaneous multi-beam delivery. This presentation will discuss various aspects related to the observation, characterization and minimization of beam loss associated with normal production beam operations in the linac.


    Institute of Scientific and Technical Information of China (English)

    Tang Baoping; Qin Shuren


    Intelligent virtual control (IVC) is an intelligent measurement instrument unit with the function of actual measurement instruments, and the unit can be used as basic building block for a variety of more complex virtual measurement instruments on a PC. IVC is a further advancement from virtual instrument (VI), and it fuses the function modules and the controls modules so that the relationship between the functions and controls of an instrument is imbedded in one or more units. The design, implementation and optimization methods of IVCs are introduced. The computer software representation of IVCs is discussed. An example of an actual VI constructed with the building blocks of IVCs is given.


    Directory of Open Access Journals (Sweden)

    Roberto. A. Rodríguez-Díaz


    Full Text Available In this work, a Fe40Al alloy was produced by the mechanical alloying technique, from a mixture of elemental powders constituted by Fe and Al, using different milling times. The evolution of size and morphology of powders depending on the milling time was characterized by scanning electron microscopy. The X-Ray Diffraction technique was utilized in order to characterize the crystalline structure evolution depending on the milling time. The Fe40Al alloy with a body centered cubic crystal structure was formed at 20 h of milling time. Besides, this alloy acquired a disordered crystal structure with a Nano metric grain size. The Nano metric grain size of disordered Fe40Al alloy was decreased at the same time as the milling time transcurred, while its lattice parameter was increased.

  20. Mechanical and microstructural characterization of geopolymer synthesized from low calcium fly ash

    Directory of Open Access Journals (Sweden)

    Kramar Sabina


    Full Text Available This study deals with the mechanical and microstructural characterization of geopolymers synthesized from locally available fly ash. A low calcium fly ash was activated using a sodium silicate solution. Samples were characterized by means of flexural and compressive tests, Fourier Transform Infrared (FTIR spectroscopy, X-ray powder diffraction (XRD, and scanning electron microscopy (SEM. Porosity and pore size distributions were identified using mercury intrusion porosimetry and gas sorption. The compressive strength of the produced geopolymers, which is in the range of 1.6 to 53.3 N/mm2, is strongly related to the water content as well as SiO2/Na2O mass ratio of an alkali activator. The compressive strength significantly increased with decreases in the water content and increased silicon concentration used for the synthesis of geopolymers.

  1. Nondestructive techniques for characterizing mechanical properties of structural materials - An overview (United States)

    Vary, A.; Klima, S. J.


    An overview of nondestructive evaluation (NDE) is presented to indicate the availability and application potentials of techniques for quantitative characterization of the mechanical properties of structural materials. The purpose is to review NDE techniques that go beyond the usual emphasis on flow detection and characterization. Discussed are current and emerging NDE techniques that can verify and monitor entrinsic properties (e.g., tensile, shear, and yield strengths; fracture toughness, hardness, ductility; elastic moduli) and underlying microstructural and morphological factors. Most of the techniques described are, at present, neither widely applied nor widely accepted in commerce and industry because they are still emerging from the laboratory. The limitations of the techniques may be overcome by advances in applications research and instrumentation technology and perhaps by accommodations for their use in the design of structural parts.

  2. Nondestructive techniques for characterizing mechanical properties of structural materials: An overview (United States)

    Vary, A.; Klima, S. J.


    An overview of nondestructive evaluation (NDE) is presented to indicate the availability and application potentials of techniques for quantitative characterization of the mechanical properties of structural materials. The purpose is to review NDE techniques that go beyond the usual emphasis on flaw detection and characterization. Discussed are current and emerging NDE techniques that can verify and monitor entrinsic properties (e.g., tensile, shear, and yield strengths; fracture toughness, hardness, ductility; elastic moduli) and underlying microstructural and morphological factors. Most of the techniques described are, at present, neither widely applied nor widely accepted in commerce and industry because they are still emerging from the laboratory. The limitations of the techniques may be overcome by advances in applications research and instrumentation technology and perhaps by accommodations for their use in the design of structural parts.

  3. Lyapunov based nonlinear control of electrical and mechanical systems (United States)

    Behal, Aman

    This Ph.D. dissertation describes the design and implementation of various control strategies centered around the following applications: (i) an improved indirect field oriented controller for the induction motor, (ii) partial state feedback control of an induction motor with saturation effects, (iii) tracking control of an underactuated surface vessel, and (iv) an attitude tracking controller for an underactuated spacecraft. The theory found in each of these sections is demonstrated through simulation or experimental results. An introduction to each of these four primary chapters can be found in chapter one. In the second chapter, the previously published tracking control of [16] 1 is presented in the indirect field oriented control (IFOC) notation to achieve exponential rotor velocity/rotor flux tracking. Specifically, it is illustrated how the proposed IFOC controller can be rewritten in the manner of [16] to allow for a direct Lyapunov stability proof. Experimental results (implemented with the IFOC algorithm) are provided to corroborate the efficacy of the algorithm. In the third chapter, a singularity-free, rotor position tracking controller is presented for the full order, nonlinear dynamic model of the induction motor that includes the effects of magnetic saturation. Specifically, by utilizing the pi-equivalent saturation model, an observer/controller strategy is designed that achieves semi-global exponential rotor position tracking and only requires stator current, rotor velocity, and rotor position measurements. Simulation and experimental results are included to demonstrate the efficacy of the proposed algorithm. In the fourth chapter, a continuous, time-varying tracking controller is designed that globally exponentially forces the position/orientation tracking error of an under-actuated surface vessel to a neighborhood about zero that can be made arbitrarily small (i.e., global uniformly ultimately boundedness (GUUB)). The result is facilitated by

  4. Mechanisms Involved in Nematode Control by Endophytic Fungi

    NARCIS (Netherlands)

    Schouten, Sander


    Colonization of plants by particular endophytic fungi can provide plants with improved defenses toward nematodes. Evidently, such endophytes can be important in developing more sustainable agricultural practices. The mechanisms playing a role in this quantitative antagonism are poorly understood


    Directory of Open Access Journals (Sweden)

    V. O. Zadoya


    Full Text Available In the article the basic approaches of improving a management mechanism for passenger suburban railway transportations are considered, and the classification of reformation models for passenger suburban railway transportations depending on scales, degree of independence, department subordination and amount of proprietors of future company is offered.

  6. Mechanisms for quality control of misfolded transmembrane proteins


    Houck, Scott A.; Cyr, Douglas M.


    To prevent the accumulation of misfolded and aggregated proteins, the cell has developed a complex network of cellular quality control (QC) systems to recognize misfolded proteins and facilitate their refolding or degradation. The cell faces numerous obstacles when performing quality control on transmembrane proteins. Transmembrane proteins have domains on both sides of a membrane and QC systems in distinct compartments must coordinate to monitor the folding status of the protein. Additionall...

  7. Group Theoretical Approach for Controlled Quantum Mechanical Systems (United States)


    evolution equation with Hamiltonians which may possess discrete , continuous, and mixed spectrum. For such a quantum system, the Hamiltonian of classical linear and nonlinear systems, which proves to be very useful in understanding the design problems such as disturbance decoupling...developed by Kunita can then be implemented to establish controllability conditions for the original time-dependent Schrodinger control problem. The end

  8. Research in Fluid Mechanics, Control Theory and Such in Yugoslavia (United States)


    microcom- verized coal in a steam reactor . There is presently a joint puter control systems, industrial robot systems, systems German and Yugoslav program on...of computer aided design to the semibatch column con- involves over 30 industrial companies and the two Slovene trol connected with the paper mill...M. Milanovic, "Computer Stefan Institute. Aided Design of Semibatch Distillation Column Control,’ Proceedings of the 2nd European Simulation Congress

  9. Quantum and classical control of single photon states via a mechanical resonator (United States)

    Basiri-Esfahani, Sahar; Myers, Casey R.; Combes, Joshua; Milburn, G. J.


    Optomechanical systems typically use light to control the quantum state of a mechanical resonator. In this paper, we propose a scheme for controlling the quantum state of light using the mechanical degree of freedom as a controlled beam splitter. Preparing the mechanical resonator in non-classical states enables an optomechanical Stern-Gerlach interferometer. When the mechanical resonator has a small coherent amplitude it acts as a quantum control, entangling the optical and mechanical degrees of freedom. As the coherent amplitude of the resonator increases, we recover single photon and two-photon interference via a classically controlled beam splitter. The visibility of the two-photon interference is particularly sensitive to coherent excitations in the mechanical resonator and this could form the basis of an optically transduced weak-force sensor.

  10. Mechanical characterization of polysilicon cantilevers using a thermo-mechanical test chip fabricated with a combined bulk/surface micromachining technique

    Directory of Open Access Journals (Sweden)

    F.J. Quiñones-N


    Full Text Available In this work a simplified low-frequency resonant method for the measurement of Young’s modulus of polysilicon cantilevers is described. We used a test chip, specially designed for characterizing thermal and mechanical properties, and fabricated using a combined bulk/surface micromachining process. In this regard, an opto-mechanical set up for the measurement of Young’s modulus is described. We use this set up for the characterization of 50 μm-wide, 1.0 μm-thick and 200–325 μm-long polysilicon cantilevers, under a mechanical excitation in the kHz frequency range.

  11. Mechanical characterization of polysilicon cantilevers using a thermo-mechanical test chip fabricated with a combined bulk/surface micromachining technique (United States)

    Quiñones-N, F. J.; De la Hidalga-W, F. J.; Moreno, M.; Molina, J.; Zúñiga, C.; Calleja, W.

    In this work a simplified low-frequency resonant method for the measurement of Young’s modulus of polysilicon cantilevers is described. We used a test chip, specially designed for characterizing thermal and mechanical properties, and fabricated using a combined bulk/surface micromachining process. In this regard, an opto-mechanical set up for the measurement of Young’s modulus is described. We use this set up for the characterization of 50 μm-wide, 1.0 μm-thick and 200-325 μm-long polysilicon cantilevers, under a mechanical excitation in the kHz frequency range.

  12. The impact of a firm's internal control mechanisms on the choice of innovation mode

    Institute of Scientific and Technical Information of China (English)

    LIU Xinmin; LI Yuan; SU Zhongfeng; FENG Jinlu


    A finn's internal control mechanisms may have a significant influence on the choice of innovation mode. Therefore, based on the research on the internal control mechanisms of companies, we developed a model to explore the relationship between a finn's internal control mechanisms and the choice of innovation mode. Using a sample of 585 Chinese finns, this study tests the proposed model. Results show that strategic control has a positive relationship with radical innovation, but a negative relationship with incremental innovation, while financial control has a negative relationship with radical innovation, but a positive relationship with incremental innovation.

  13. Spacecraft dynamics characterization and control system failure detection (United States)

    Vandervelde, Wallace E.


    Two important aspects of the control of large space structures are studied: the modeling of deployed or erected structures including nonlinear joint characteristics; and the detection and isolation of failures of the components of control systems for large space structures. The emphasis in the first task is on efficient representation of the dynamics of large and complex structures having a great many joints. The initial emphasis in the second task is on experimental evaluation of FDI methodologies using ground-based facilities in place at NASA Langley Research Center and Marshall Space Flight Center. The progress to date on both research tasks is summarized.

  14. Mechanical characterization and modelling of the heavy tungsten allow IT180

    CERN Document Server

    Scapin, M


    In this work, the mechanical characterization and the consequent material modeling of the tungsten alloy INERMET® IT180 were performed. The material is actually used in the collimation system of the Large Hadron Collider at CERN and several studies are currently under development in order to be able to numerically predict the material damage in case of energy beamimpact, but to do this, a confident strength model has to be obtained. This is the basis of this work, in which a test campaign in compression and tension at different strain-rates and tempe...

  15. Controllable growth and characterizations of hybrid spiral-like atomically thin molybdenum disulfide (United States)

    Hao, Song; Yang, Bingchu; Gao, Yongli


    Monolayer MoS2 is an emerging two-dimensional semiconductor with wide-ranging potential applications in novel electronic and optoelectronic devices. Here, we reported controlled vapor phase growth of hybrid spiral-like MoS2 crystals investigated by multiple means of X-Ray photoemission spectroscopy, scanning electron microscopy, atomic force microscopy, kelvin probe force microscopy, Raman and Photoluminescence techniques. Morphological characterizations reveal an intriguing hybrid spiral-like MoS2 feature whose lower planes are AB Bernal stacking and upper structure is spiral. We ascribe the hybrid spiral-like structure to a screw dislocation drive growth mechanism owing to lower supersaturation and layer-by-layer growth mode. In addition, the electrostatic properties of MoS2 microflakes with hybrid spiral structures are obvious inhomogeneous and dependent on morphology manifested by kelvin probe force microscopy. Our work deepens the understanding of growth mechanisms of CVD-grown MoS2, which is also adoptable to other TMDC materials.

  16. Preparation, characterization and mechanical properties of rare-earth-based nanocomposites

    Directory of Open Access Journals (Sweden)

    Musbah S.S.


    Full Text Available This study reports research related to different preparation methods and characterization of polymer nanocomposites for optical applications. The Eu-ion doped Gd2O3 nanophosphor powder with different nanoparticle content was embedded in the matrix of PMMA. Preparation was carried out by mixing molding (bulk, electrospinning (nanofibers and solution casting (thin films with neat particles and particles coated with AMEO silane. Among the pros and cons for proposed methods, the mixing molding enables to avoid solvent use while the best deagglomeration and nanoparticle distribution is gained using the electrospinning method. The results of dynamic mechanical analysis (DMA and nanoindentation revealed that the storage modulus of the composites was higher than that of pure PMMA and increased with nanophosphor content. Surface modification of particles improved the mechanical properties of nanocomposites.

  17. Mechanical characterization of TiO{sub 2} nanofibers produced by different electrospinning techniques

    Energy Technology Data Exchange (ETDEWEB)

    Vahtrus, Mikk [Institute of Physics, University of Tartu, Ravila 14c, 50412 Tartu (Estonia); Šutka, Andris [Institute of Physics, University of Tartu, Ravila 14c, 50412 Tartu (Estonia); Institute of Silicate Materials, Riga Technical University, P. Valdena 3/7, Riga LV-1048 (Latvia); Institute of Technical Physics, Riga Technical University, P. Valdena 3, Riga LV-1048 (Latvia); Vlassov, Sergei, E-mail: [Institute of Solid State Physics, University of Latvia, Kengaraga 8, LV-1063 Riga (Latvia); Šutka, Anna [Institute of Textile Technology and Design, Riga Technical University, Riga LV-1048 (Latvia); Laboratory of Biomass Eco-Efficient Conversation, Latvian State Institute of Wood Chemistry, Dzerbenes Street 27, Riga LV-1006 (Latvia); Polyakov, Boris [Institute of Solid State Physics, University of Latvia, Kengaraga 8, LV-1063 Riga (Latvia); Saar, Rando; Dorogin, Leonid; Lõhmus, Rünno [Institute of Physics, University of Tartu, Ravila 14c, 50412 Tartu (Estonia); Materials Technologies Competence Centre, Riia 185b, 51014 Tartu (Estonia)


    In this work TiO{sub 2} nanofibers produced by needle and needleless electrospinning processes from the same precursor were characterized and compared using Raman spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and in situ SEM nanomechanical testing. Phase composition, morphology, Young's modulus and bending strength values were found. Weibull statistics was used to evaluate and compare uniformity of mechanical properties of nanofibers produced by two different methods. It is shown that both methods yield nanofibers with very similar properties. - Graphical abstract: Display Omitted - Highlights: • TiO{sub 2} nanofibers were produced by needle and needleless electrospinning processes. • Structure was studied by Raman spectroscopy and electron microscopy methods. • Mechanical properties were measured using advanced in situ SEM cantilevered beam bending technique. • Both methods yield nanofibers with very similar properties.

  18. Wet processing and characterization of ZrO2/stainless steel composites: electrical and mechanical perfomance

    Directory of Open Access Journals (Sweden)

    S. López-Esteban


    Full Text Available Zirconia/stainless steel composites have been prepared by a wet processing method with metal volume concentration ranging from 15% to 30%. The composites were characterized by electrical and mechanical measurements. The dependence of the electrical properties of these composites with the metal concentration presents a percolative behaviour with a metal-insulator transition, in addition to an increment of the capacity in the neighbourhood of a critical volume concentration. This value was found to be f c = 0.285, which is much higher than the theoretical value for randomly dispersed 3D composites (f c = 0.16. It has been found that the incorporation of stainless steel particles to zirconia matrix, increases the toughness and decreases both the hardness and the flexural strength. The enhancement of toughness is attributed to a crack deflection mechanism as a consequence of a weak ZrO2/stainless steel interface.

  19. Characterization of Microstructure and Mechanical Properties of Resistance Spot Welded DP600 Steel

    Directory of Open Access Journals (Sweden)

    Ali Ramazani


    Full Text Available Resistance spot welding (RSW as a predominant welding technique used for joining steels in automotive applications needs to be studied carefully in order to improve the mechanical properties of the spot welds. The objectives of the present work are to characterize the resistance spot weldment of DP600 sheet steels. The mechanical properties of the welded joints were evaluated using tensile-shear and cross-tensile tests. The time-temperature evolution during the welding cycle was measured. The microstructures observed in different sites of the welds were correlated to thermal history recorded by thermocouples in the corresponding areas. It was found that cracks initiated in the periphery region of weld nuggets with a martensitic microstructure and a pull-out failure mode was observed. It was also concluded that tempering during RSW was the main reason for hardness decrease in HAZ.

  20. A probabilistic approach to rock mechanical property characterization for nuclear waste repository design

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kunsoo; Gao, Hang [Columbia Univ., New York, NY (United States)


    A probabilistic approach is proposed for the characterization of host rock mechanical properties at the Yucca Mountain site. This approach helps define the probability distribution of rock properties by utilizing extreme value statistics and Monte Carlo simulation. We analyze mechanical property data of tuff obtained by the NNWSI Project to assess the utility of the methodology. The analysis indicates that laboratory measured strength and deformation data of Calico Hills and Bullfrog tuffs follow an extremal. probability distribution (the third type asymptotic distribution of the smallest values). Monte Carlo simulation is carried out to estimate rock mass deformation moduli using a one-dimensional tuff model proposed by Zimmermann and Finley. We suggest that the results of these analyses be incorporated into the repository design.

  1. Synthesis and Characterization of Imide Containing Hybrid Epoxy Resin with Improved Mechanical and Thermal Properties

    Directory of Open Access Journals (Sweden)

    U. G. Rane


    Full Text Available Phosphorous containing amine, tripropyldiamine phosphine oxide (TPDAP, and hybrid monomer 4-(N-phthalimidophenyl glycidylether (PPGE were synthesized and characterized by Fourier transform infrared (FTIR spectroscopy, nuclear magnetic resonance (NMR spectroscopy, and elemental analysis (EDX. PPGE was incorporated in bisphenol A epoxy resin (BPA in various concentrations (5% to 20%, based on a weight percentage of BPA resin. Curing was carried out with the stoichiometric amount of TPDAP and 1,3-propanediamine (PDA to result in cross-link network. Various mechanical, chemical, thermal, and flame retardant properties of modified and unmodified epoxy resin were studied. The coatings obtained with the addition of PPGE were found to have improved properties as compared with those of the unmodified resin. Coatings with 15% loading of PPGE showed improved flame retardant and mechanical properties with stable thermal behaviour.

  2. Walnut-like In2S3 microspheres: ionic liquid-assisted solvothermal synthesis, characterization and formation mechanism (United States)

    Chai, Bo; Zeng, Peng; Zhang, Xiaohu; Mao, Jin; Zan, Ling; Peng, Tianyou


    Walnut-like In2S3 microspheres were synthesized through an ionic liquid-assisted solvothermal method for the first time. The crystal structure and morphology of the as-synthesized products were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), energy-dispersive X-ray (EDX) spectroscopy, X-ray photoelectron spectroscopy (XPS), UV-vis diffuse reflectance spectra (DRS) and nitrogen adsorption-desorption measurement. It was found that the additional amount of ionic liquid, solvothermal temperature and time played crucial roles in controlling the structure and morphology of the In2S3 microspheres. A possible formation mechanism of the walnut-like In2S3 microsphere was proposed on the basis of the experimental results.

  3. Walnut-like In2S3 microspheres: ionic liquid-assisted solvothermal synthesis, characterization and formation mechanism. (United States)

    Chai, Bo; Zeng, Peng; Zhang, Xiaohu; Mao, Jin; Zan, Ling; Peng, Tianyou


    Walnut-like In(2)S(3) microspheres were synthesized through an ionic liquid-assisted solvothermal method for the first time. The crystal structure and morphology of the as-synthesized products were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), energy-dispersive X-ray (EDX) spectroscopy, X-ray photoelectron spectroscopy (XPS), UV-vis diffuse reflectance spectra (DRS) and nitrogen adsorption-desorption measurement. It was found that the additional amount of ionic liquid, solvothermal temperature and time played crucial roles in controlling the structure and morphology of the In(2)S(3) microspheres. A possible formation mechanism of the walnut-like In(2)S(3) microsphere was proposed on the basis of the experimental results.

  4. Nondestructive Methods to Characterize Rock Mechanical Properties at Low-Temperature: Applications for Asteroid Capture Technologies (United States)

    Savage, Kara A.

    Recent government initiatives and commercial activities have targeted asteroids for in situ material characterization, manipulation, and possible resource extraction. Most of these activities and missions have proposed significant robotic components, given the risks and costs associated with manned missions. To successfully execute these robotic activities, detailed mechanical characteristics of the target space bodies must be known prior to contact, in order to appropriately plan and direct the autonomous robotic protocols. Unfortunately, current estimates of asteroid mechanical properties are based on limited direct information, and significant uncertainty remains specifically concerning internal structures, strengths, and elastic properties of asteroids. One proposed method to elucidate this information is through in situ, nondestructive testing of asteroid material immediately after contact, but prior to any manipulation or resource extraction activities. While numerous nondestructive rock characterization techniques have been widely deployed for terrestrial applications, these methods must be adapted to account for unique properties of asteroid material and environmental conditions of space. For example, asteroid surface temperatures may range from -100°C to 30°C due to diurnal cycling, and these low temperatures are especially noteworthy due to their deleterious influence on non-destructive testing. As a result, this thesis investigates the effect of low temperature on the mechanical characteristics and nondestructive technique responses of rock material. Initially, a novel method to produce low temperature rock samples was developed. Dry ice and methanol cooling baths of specific formulations were used to decrease rock to temperatures ranging from -60°C to 0°C. At these temperatures, shale, chalk, and limestone rock samples were exposed to several nondestructive and conventional mechanical tests, including Schmidt hammer, ultrasonic pulse velocity, point

  5. Characterization of Tensile Mechanical Behavior of MSCs/PLCL Hybrid Layered Sheet

    Directory of Open Access Journals (Sweden)

    Azizah Intan Pangesty


    Full Text Available A layered construct was developed by combining a porous polymer sheet and a cell sheet as a tissue engineered vascular patch. The primary objective of this study is to investigate the influence of mesenchymal stem cells (MSCs sheet on the tensile mechanical properties of porous poly-(l-lactide-co-ε-caprolactone (PLCL sheet. The porous PLCL sheet was fabricated by the solid-liquid phase separation method and the following freeze-drying method. The MSCs sheet, prepared by the temperature-responsive dish, was then layered on the top of the PLCL sheet and cultured for 2 weeks. During the in vitro study, cellular properties such as cell infiltration, spreading and proliferation were evaluated. Tensile test of the layered construct was performed periodically to characterize the tensile mechanical behavior. The tensile properties were then correlated with the cellular properties to understand the effect of MSCs sheet on the variation of the mechanical behavior during the in vitro study. It was found that MSCs from the cell sheet were able to migrate into the PLCL sheet and actively proliferated into the porous structure then formed a new layer of MSCs on the opposite surface of the PLCL sheet. Mechanical evaluation revealed that the PLCL sheet with MSCs showed enhancement of tensile strength and strain energy density at the first week of culture which is characterized as the effect of MSCs proliferation and its infiltration into the porous structure of the PLCL sheet. New technique was presented to develop tissue engineered patch by combining MSCs sheet and porous PLCL sheet, and it is expected that the layered patch may prolong biomechanical stability when implanted in vivo.

  6. Mechanical AGN Feedback: Controlling the Thermodynamical Evolution of Elliptical Galaxies

    CERN Document Server

    Gaspari, M; Temi, P


    A fundamental gap in the current understanding of galaxies concerns the thermodynamical evolution of the ordinary, baryonic matter. On one side, radiative emission drastically decreases the thermal energy content of the interstellar plasma (ISM), inducing a slow cooling flow toward the centre. On the other side, the active galactic nucleus (AGN) struggles to prevent the runaway cooling catastrophe, injecting huge amount of energy in the ISM. The present study intends to deeply investigate the role of mechanical AGN feedback in (isolated or massive) elliptical galaxies, extending and completing the mass range of tested cosmic environments. Our previously successful feedback models, in galaxy clusters and groups, demonstrated that AGN outflows, self-regulated by cold gas accretion, are able to properly quench the cooling flow, without destroying the cool core. Via 3D hydrodynamic simulations (FLASH 3.3), including also stellar evolution, we show that massive mechanical AGN outflows can indeed solve the cooling ...

  7. Mechanical control over valley magnetotransport in strained graphene

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Ning, E-mail: [Department of Physics, MOE Key Laboratory of Advanced Transducers and Intelligent Control System, Taiyuan University of Technology, Taiyuan 030024 (China); Department of Applied Physics, MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi' an Jiaotong University, Xi' an 710049 (China); Zhang, Shengli, E-mail: [Department of Applied Physics, MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi' an Jiaotong University, Xi' an 710049 (China); Liu, Daqing, E-mail: [School of Mathematics and Physics, Changzhou University, Changzhou 213164 (China)


    Recent experiments report that the graphene exhibits Landau levels (LLs) that form in the presence of a uniform strain pseudomagnetic field with magnitudes up to hundreds of tesla. We further reveal that the strain removes the valley degeneracy in LLs, and leads to a significant valley polarization with inversion symmetry broken. This accordingly gives rise to the well separated valley Hall plateaus and Shubnikov–de Haas oscillations. These effects are absent in strainless graphene, and can be used to generate and detect valley polarization by mechanical means, forming the basis for the new paradigm “valleytronics” applications. - Highlights: • We explore the mechanical strain effects on the valley magnetotransport in graphene. • We analytically derive the dc collisional and Hall conductivities under strain. • The strain removes the valley degeneracy in Landau levels. • The strain causes a significant valley polarization with inversion symmetry broken. • The strain leads to the well separated valley Hall and Shubnikov–de Haas effects.

  8. Mechanically Controlled Electron Transfer in a Single-Polypeptide Transistor (United States)

    Sheu, Sheh-Yi; Yang, Dah-Yen


    Proteins are of interest in nano-bio electronic devices due to their versatile structures, exquisite functionality and specificity. However, quantum transport measurements produce conflicting results due to technical limitations whereby it is difficult to precisely determine molecular orientation, the nature of the moieties, the presence of the surroundings and the temperature; in such circumstances a better understanding of the protein electron transfer (ET) pathway and the mechanism remains a considerable challenge. Here, we report an approach to mechanically drive polypeptide flip-flop motion to achieve a logic gate with ON and OFF states during protein ET. We have calculated the transmission spectra of the peptide-based molecular junctions and observed the hallmarks of electrical current and conductance. The results indicate that peptide ET follows an NC asymmetric process and depends on the amino acid chirality and α-helical handedness. Electron transmission decreases as the number of water molecules increases, and the ET efficiency and its pathway depend on the type of water-bridged H-bonds. Our results provide a rational mechanism for peptide ET and new perspectives on polypeptides as potential candidates in logic nano devices.

  9. Sand control mechanism analysis of metallic wool screen

    Energy Technology Data Exchange (ETDEWEB)

    Yongquan, H.; Jinzhou, Z.; Zhinjun, W.; Zhaofeng, L. [Southwest Petroleum Institute, China, (China); Lei, Y. [Liaohe petroleum Administration, China, (China)


    A filter prepacked with metallic wool was developed and claimed to have been effectively used on thermal and unconsolidated sand oil wells. Structural features of the filter screen and the factors having a bearing on its sand control function, such as particle characteristics, fluid properties, environmental conditions, and the filtering characteristics of metallic wool, were discussed. Some experimental results have been provided to illustrate desirable characteristics and advantages. According to this evidence, sanding velocity is highest at the beginning, stabilizing gradually. Production pressure drop must be appropriately adjusted to achieve best results with well sanding control. 9 refs., 1 tab., 5 figs.

  10. Decoherence control: A feedback mechanism based on hamiltonian tracking

    CERN Document Server

    Katz, G; Kosloff, R; Katz, Gil; Ratner, Mark; Kosloff, Ronnie


    Enviroment - caused dissipation disrupts the hamiltonian evolution of all quantum systems not fully isolated from any bath. We propose and examine a feedback-control scheme to eliminate such dissipation, by tracking the free hamiltonian evolution. We determine a driving-field that maximizes the projection of the actual molecular system onto the freely propagated one. The evolution of a model two level system in a dephasing bath is followed, and the driving field that overcomes the decoherence is calculated. An implementation of the scheme in the laboratory using feedback control is suggested.

  11. CO2 sequestration in deep coal seams: experimental characterization of the fundamental underlying mechanisms (United States)

    Pini, R.; Mazzotti, M.


    The process of injecting and storing carbon dioxide (CO2) into suitable deep geological formations, such as saline aquifers, (depleted) oil or gas reservoirs, and unmineable coal seams, is referred to as CO2 sequestration. In little more than a decade, this technology has emerged as one of the most important options for reducing CO2 emissions. Among the different options, unmineable coal seams are not as broadly distributed as saline aquifers or oil/gas reservoirs, but their peculiarity resides in the proven capacity of retaining significant amount of gas (mainly methane, CH4) for a very long time. Additionally, the injection of CO2 into the coal reservoir would enhance the recovery of this natural gas, a source of energy that will most likely play a key role in the power sector over the next 20 years from now. This process is called Enhanced Coal Bed Methane (ECBM) recovery and, as for enhanced oil recovery, it allows in principle offsetting the costs associated to the storage operation. A study was undertaken aimed at the experimental characterization of the fundamental mechanisms that take place during the process of injection and storage in coal reservoirs, namely adsorption and swelling (Pini et al 2010), and of their effects on the coal's permeability (Pini et al. 2009), the property that plays a dominant role in controlling fluid transport in a porous rock. An apparatus has been built that allows measuring the permeability of rock cores under typical reservoir conditions (high pressure and temperature) by the so-called transient step method. For this study, a coal core from the Sulcis coal mine in Sardinia (Italy) has been used. In the experiments, an inert gas (helium) was used to investigate the effects of the effective pressure on the permeability of the coal sample, whereas two adsorbing gases (CO2 and N2) to quantify those of adsorption and swelling. The experiments have been interpreted by a one-dimensional model that describes the fluid transport

  12. Mechanical Characterization and Constitutive Modeling of Human Trachea: Age and Gender Dependency

    Directory of Open Access Journals (Sweden)

    Farzaneh Safshekan


    Full Text Available Tracheal disorders can usually reduce the free lumen diameter or wall stiffness, and hence limit airflow. Trachea tissue engineering seems a promising treatment for such disorders. The required mechanical compatibility of the prepared scaffold with native trachea necessitates investigation of the mechanical behavior of the human trachea. This study aimed at mechanical characterization of human tracheas and comparing the results based on age and gender. After isolating 30 human tracheas, samples of tracheal cartilage, smooth muscle, and connective tissue were subjected to uniaxial tension to obtain force-displacement curves and calculate stress-stretch data. Among several models, the Yeoh and Mooney-Rivlin hyperelastic functions were best able to describe hyperelastic behavior of all three tracheal components. The mean value of the elastic modulus of human tracheal cartilage was calculated to be 16.92 ± 8.76 MPa. An overall tracheal stiffening with age was observed, with the most considerable difference in the case of cartilage. Consistently, we noticed some histological alterations in cartilage and connective tissue with aging, which may play a role in age-related tracheal stiffening. No considerable effect of gender on the mechanical behavior of tracheal components was observed. The results of this study can be applied in the design and fabrication of trachea tissue engineering scaffolds.

  13. Mechanical characterization of an unusual elastic biomaterial from the egg capsules of marine snails (Busycon spp.). (United States)

    Rapoport, H Scott; Shadwick, Robert E


    Egg capsule material serves as a putative protection mechanism for developing snail embryos facing the perils of the marine environment. We conducted the first quantitative study of this acellular structural protein with the goals of characterizing its chemical and mechanical properties and the relationship of these properties to its biological protective function. We have found that this protein polymer exhibits long-range elasticity with an interesting recoverable yield evidenced by an order of magnitude decrease in elastic modulus (apparent failure) that begins at 3%-5% strain. This material differs significantly from other common structural proteins such as collagen and elastin in mechanical response to strain. Qualitative similarities in stress/strain behavior to keratin, another common structural protein, are more than coincidental when composition and detailed mechanical quantification are considered. This suggests the possibility of alpha-helical structure and matrix organization that might be similar in these two proteins. Indeed, the egg capsule protein may be closely related to vertebrate keratins such as intermediate filaments. We conclude that while this material's bimodal tensile properties may serve as useful protection against the impact loading egg capsules encounter in the intertidal zone, the full biological importance of these capsules is not known.

  14. Characterization of PV modules by combining results of mechanical and electrical analysis methods (United States)

    Sander, Martin; Henke, Bastian; Schwarz, Hannes; Dietrich, Sascha; Schweizer, Stefan; Ebert, Matthias; Bagdahn, Jörg


    Photovoltaic modules (PV modules) are supposed to have a lifetime of more than 20 years under various environmental conditions like temperature changes, mechanical loads, etc. Common outdoor exposure may influence efficiency and lifetime which necessitates assessment of PV module performance and detection of output deficits. For this purpose reliable and nondestructive testing methods are desirable. Commercially available PV modules were tested by different analysis methods. The PV module's electrical properties were investigated by thermography and electroluminescence measurements. The combination of these two techniques is well-suited to detect many cell and module defects. A crystalline module showed significant cell breakage after temperature cycle test. To observe the mechanisms of this specific defect type laminated test specimens on smaller scales were produced and analyzed over production process and during temperature cycles derived from the international standards IEC 61215 and IEC 61646. The defect study on small scales allows conclusions about the defect's influence on larger PV modules. Further methods capable for mechanical characterization like Laser Doppler vibrometry, surface geometry scan and digital image correlation are presented briefly. The combination of the methods mentioned above allows a very precise assessment of the mechanical and electrical capability which is essential for reliability and lifetime concepts.

  15. Nano-mechanical characterization of tension-sensitive helix bundles in talin rod. (United States)

    Maki, Koichiro; Nakao, Nobuhiko; Adachi, Taiji


    Tension-induced exposure of a cryptic signaling binding site is one of the most fundamental mechanisms in molecular mechanotransduction. Helix bundles in rod domains of talin, a tension-sensing protein at focal adhesions, unfurl under tension to expose cryptic vinculin binding sites. Although the difference in their mechanical stabilities would determine which helix bundle is tension-sensitive, their respective mechanical behaviors under tension have not been characterized. In this study, we evaluated the mechanical behaviors of residues 486-654 and 754-889 of talin, which form helix bundles with low and high tension-sensitivity, by employing AFM nano-tensile testing. As a result, residues 754-889 exhibited lower unfolding energy for complete unfolding than residues 486-654. In addition, we found that residues 754-889 transition into intermediate conformations under lower tension than residues 486-654. Furthermore, residues 754-889 showed shorter persistence length in the intermediate conformation than residues 486-654, suggesting that residues 754-889 under tension exhibit separated α-helices, while residues 486-654 assume a compact conformation with inter-helix interactions. Therefore, we suggest that residues 754-889 of talin work as a tension-sensitive domain to recruit vinculin at the early stage of focal adhesion development, while residues 486-654 contribute to rather robust tension-sensitivity by recruiting vinculin under high tension.

  16. Synthesis and characterization of zinc titanate nano-crystal powders obtained by mechanical activation

    Directory of Open Access Journals (Sweden)

    Obradović Nina


    Full Text Available Development of dielectric materials for microwave frequencies is increasing with rapid progress in mobile and satellite communications systems, where zinc titanates have found application due to their semi-conducting and dielectric properties. Mechanical activation by grinding is a well-known method and common part of the powder preparation route in the field of ceramics. The aim of this work is investigation of the influence of experimental conditions for mechanochemical synthesis of zinc orthotitanate. Starting powder mixtures of ZnO and TiO2, in the molar ratio that is in accordance with the stoichiometry of zinc titanate spinel type Zn2TiO4, were mechanically activated using a high-energy planetary ball mill. The process of mechanical activation was performed during different time intervals from 0 to 300 minutes. Microstructure characterization was determined by X-ray diffraction analysis and scanning electron microscopy. Also, the specific surface area (SSA of powders samples was measured by a nitrogen gas sorption analyzer using the BET method. The very first traces of zinc titanate are detectable after only 5 minutes of activation. The most interesting occurrence during the mechanical method of activation is that we have an almost pure phase after 90 minutes.

  17. Finite element simulation for the mechanical characterization of soft biological materials by atomic force microscopy. (United States)

    Valero, C; Navarro, B; Navajas, D; García-Aznar, J M


    The characterization of the mechanical properties of soft materials has been traditionally performed through uniaxial tensile tests. Nevertheless, this method cannot be applied to certain extremely soft materials, such as biological tissues or cells that cannot be properly subjected to these tests. Alternative non-destructive tests have been designed in recent years to determine the mechanical properties of soft biological tissues. One of these techniques is based on the use of atomic force microscopy (AFM) to perform nanoindentation tests. In this work, we investigated the mechanical response of soft biological materials to nanoindentation with spherical indenters using finite element simulations. We studied the responses of three different material constitutive laws (elastic, isotropic hyperelastic and anisotropic hyperelastic) under the same process and analyzed the differences thereof. Whereas linear elastic and isotropic hyperelastic materials can be studied using an axisymmetric simplification, anisotropic hyperelastic materials require three-dimensional analyses. Moreover, we established the limiting sample size required to determine the mechanical properties of soft materials while avoiding boundary effects. Finally, we compared the results obtained by simulation with an estimate obtained from Hertz theory. Hertz theory does not distinguish between the different material constitutive laws, and thus, we proposed corrections to improve the quantitative measurement of specific material properties by nanoindentation experiments.

  18. Mechanical characterization of the role of defects in sintered FeCrAIY foams

    Institute of Scientific and Technical Information of China (English)

    M. Kepets; T. J. Lu; A. P. Dowling


    Open celled metal foams fabricated through metal sintering are a new class of material that offers novel mechanical and acoustic properties. Previously, polymer foams have been widely used as a means of absorbing acous-tic energy. However, the structural applications of these foams are limited. The metal sintering approach offers a cost-effective means for the mass-production of open-cell foams from a range of materials, including high-temperature steel alloys. In this first part of two-paper series, the mechanical properties of open-celled steel alloy (FeCrAlY) foams were characterized under uniaxial compression and shear loading.Compared to predictions from established models, a signi-ficant knockdown in material properties was observed. This knockdown was attributed to the presence of defects throu-ghout the microstructure that result from the unique fabri-cation process. Further in situ tests were carded out in a SEM (scanning electronic microscope) in order to investigate the effects of defects on the properties of the foams. Typi-cally, the onset of plastic yielding was observed to occur at defect locations within the microstructure. At lower relative densities, ligament bending dominates, with the deformation initializing at defects. At higher relative densities, an additional deformation mechanism associated with mem-brane elements was observed. In the follow-up of this paper,a finite element model will be constructed to quantify the effects of defects on the mechanical performance of the open-cell foam.

  19. Genetic characterization of p27(kip1) and stathmin in controlling cell proliferation in vivo. (United States)

    Berton, Stefania; Pellizzari, Ilenia; Fabris, Linda; D'Andrea, Sara; Segatto, Ilenia; Canzonieri, Vincenzo; Marconi, Daniela; Schiappacassi, Monica; Benevol, Sara; Gattei, Valter; Colombatti, Alfonso; Belletti, Barbara; Baldassarre, Gustavo


    The CDK inhibitor p27(kip1) is a critical regulator of cell cycle progression, but the mechanisms by which p27(kip1) controls cell proliferation in vivo are still not fully elucidated. We recently demonstrated that the microtubule destabilizing protein stathmin is a relevant p27(kip1) binding partner. To get more insights into the in vivo significance of this interaction, we generated p27(kip1) and stathmin double knock-out (DKO) mice. Interestingly, thorough characterization of DKO mice demonstrated that most of the phenotypes of p27(kip1) null mice linked to the hyper-proliferative behavior, such as the increased body and organ weight, the outgrowth of the retina basal layer and the development of pituitary adenomas, were reverted by co-ablation of stathmin. In vivo analyses showed a reduced proliferation rate in DKO compared to p27(kip1) null mice, linked, at molecular level, to decreased kinase activity of CDK4/6, rather than of CDK1 and CDK2. Gene expression profiling of mouse thymuses confirmed the phenotypes observed in vivo, showing that DKO clustered with WT more than with p27 knock-out tissue. Taken together, our results demonstrate that stathmin cooperates with p27(kip1) to control the early phase of G1 to S phase transition and that this function may be of particular relevance in the context of tumor progression.

  20. Molecular characterization of the stomach microbiota in patients with gastric cancer and controls

    Energy Technology Data Exchange (ETDEWEB)

    Dicksved, J.; Lindberg, M.; Rosenquist, M.; Enroth, H.; Jansson, J.K.; Engstrand, L.


    Persistent infection of the gastric mucosa by Helicobacter pylori, can initiate an inflammatory cascade that progresses into atrophic gastritis, a condition associated with reduced capacity for secretion of gastric acid and an increased risk in developing gastric cancer. The role of H. pylori as an initiator of inflammation is evident but the mechanism for development into gastric cancer has not yet been proven. A reduced capacity for gastric acid secretion allows survival and proliferation of other microbes that normally are killed by the acidic environment. It has been postulated that some of these species may be involved in the development of gastric cancer, however their identities are poorly defined. In this study, the gastric microbiota from ten patients with gastric cancer was characterized and compared with five dyspeptic controls using the molecular profiling approach, terminal-restriction fragment length polymorphism (T-RFLP), in combination with 16S rRNA gene cloning and sequencing. T-RFLP analysis revealed a complex bacterial community in the cancer patients that was not significantly different from the controls. Sequencing of 140 clones revealed 102 phylotypes, with representatives from five bacterial phyla (Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria and Fusobacteria). The data revealed a relatively low abundance of H. pylori and showed that the gastric cancer microbiota was instead dominated by different species of the genera Streptococcus, Lactobacillus, Veillonella and Prevotella. The respective role of these species in development of gastric cancer remains to be determined.

  1. Systematic characterization of porosity and mass transport and mechanical properties of porous polyurethane scaffolds. (United States)

    Wang, Yu-Fu; Barrera, Carlos M; Dauer, Edward A; Gu, Weiyong; Andreopoulos, Fotios; Huang, C-Y Charles


    One of the key challenges in porous scaffold design is to create a porous structure with desired mechanical function and mass transport properties which support delivery of biofactors and development of function tissue substitute. In recent years, polyurethane (PU) has become one of the most popular biomaterials in various tissue engineering fields. However, there are no studies fully investigating the relations between porosity and both mass transport and mechanical properties of PU porous scaffolds. In this paper, we fabricated PU scaffolds by combining phase inversion and salt (sodium chloride) leaching methods. The tensile and compressive moduli were examined on PU scaffolds fabricated with different PU concentrations (25%, 20% and 15% w/v) and salt/PU weight ratios (9/1, 6/1, 3/1 and 0/1). The mass transport properties of PU scaffolds including hydraulic permeability and glucose diffusivity were also measured. Furthermore, the relationships between the porosity and mass transport and mechanical properties of porous PU scaffold were systemically investigated. The results demonstrated that porosity is a key parameter which governs both mass transport and mechanical properties of porous PU scaffolds. With similar pore sizes, the mass transport and mechanical properties of porous PU scaffold can be described as single functions of porosity regardless of initial PU concentration. The relationships between scaffold porosity and properties can be utilized to facilitate porous PU scaffold fabrication with specific mass transport and mechanical properties. The systematic approach established in this study can be applied to characterization of other biomaterials for scaffold design and fabrication.

  2. Peptide Characterization of Mature Fluorotic and Control Human Enamel. (United States)

    Lelis, Isabel Maria Porto; Molina, Gabriela F; Souza, Cláudia; Perez, Walter B; Laure, Helen J; Rosa, José C; Gerlach, Raquel F


    Exposure to high fluoride levels during amelogenesis causes enamel fluorosis. This study aimed to determine and compare the amino acid sequences in the enamel of fluorotic and control teeth. This investigation included enamel samples obtained from erupted and non-erupted third molars with either TF grade 4-6 (n=7) fluorosis or no sign of fluorosis (controls, n=7). The samples were kept frozen at -20 °C until protein extraction. Samples were etched and processed with a cocktail of proteinase inhibitors and immediately analyzed. Matrix Assisted Laser Desorption/Ionization-Time-Of-Flight/Time-of-Flight Mass Spectrometry (MALDI-TOF/TOF) followed by MASCOT search aided the peptides analysis. The more abundant peptides bore the N-terminal amelogenin sequences WYQSIRPPYP (which is specific for the X-encoded amelogenin) and MPLPPHPGHPGYINF (which does not show sexual dimorphism) were not different in control or fluorotic enamel. There was no missing proteolytic cleavage in the fluorotic samples, which suggested that the increased amount of protein described in fluorotic enamel did not stem from the decreased ability of proteinases to cleave the proteins in humans. This study showed how to successfully obtain peptide from superficial enamel. A relatively low number of teeth was sufficient to provide good data on the actual peptides found in mature enamel.

  3. Energy technology characterizations handbook: environmental pollution and control factors. Third edition

    Energy Technology Data Exchange (ETDEWEB)


    This Handbook deals with environmental characterization information for a range of energy-supply systems and provides supplementary information on environmental controls applicable to a select group of environmentally characterized energy systems. Environmental residuals, physical-resource requirements, and discussion of applicable standards are the principal information provided. The quantitative and qualitative data provided are useful for evaluating alternative policy and technical strategies and for assessing the environmental impact of facility siting, energy production, and environmental controls.

  4. Lie Algebroids in Classical Mechanics and Optimal Control

    Directory of Open Access Journals (Sweden)

    Eduardo Martínez


    Full Text Available We review some recent results on the theory of Lagrangian systems on Lie algebroids. In particular we consider the symplectic and variational formalism and we study reduction. Finally we also consider optimal control systems on Lie algebroids and we show how to reduce Pontryagin maximum principle.

  5. Shale Failure Mechanics and Intervention Measures in Underground Coal Mines: Results From 50 Years of Ground Control Safety Research (United States)

    Murphy, M. M.


    Ground control research in underground coal mines has been ongoing for over 50 years. One of the most problematic issues in underground coal mines is roof failures associated with weak shale. This paper will present a historical narrative on the research the National Institute for Occupational Safety and Health has conducted in relation to rock mechanics and shale. This paper begins by first discussing how shale is classified in relation to coal mining. Characterizing and planning for weak roof sequences is an important step in developing an engineering solution to prevent roof failures. Next, the failure mechanics associated with the weak characteristics of shale will be discussed. Understanding these failure mechanics also aids in applying the correct engineering solutions. The various solutions that have been implemented in the underground coal mining industry to control the different modes of failure will be summarized. Finally, a discussion on current and future research relating to rock mechanics and shale is presented. The overall goal of the paper is to share the collective ground control experience of controlling roof structures dominated by shale rock in underground coal mining.

  6. Snail levels control the migration mechanism of mesenchymal tumor cells. (United States)

    Belgiovine, Cristina; Chiesa, Giulio; Chiodi, Ilaria; Frapolli, Roberta; Bonezzi, Katiuscia; Taraboletti, Giulia; D'Incalci, Maurizio; Mondello, Chiara


    Cancer cells use two major types of movement: Mesenchymal, which is typical of cells of mesenchymal origin and depends on matrix metalloproteinase (MMP) activity, and amoeboid, which is characteristic of cells with a rounded shape and relies on the activity of Rho-associated kinase (ROCK). The present authors previously demonstrated that, during neoplastic transformation, telomerase-immortalized human fibroblasts (cen3tel cells) acquired a ROCK-dependent/MMP independent mechanism of invasion, mediated by the downregulation of the ROCK cellular inhibitor Round (Rnd)3/RhoE. In the present study, cen3tel transformation was also demonstrated to be paralleled by downregulation of Snail, a major determinant of the mesenchymal movement. To test whether Snail levels could determine the type of movement adopted by mesenchymal tumor cells, Snail was ectopically expressed in tumorigenic cells. It was observed that ectopic Snail did not increase the levels of typical mesenchymal markers, but induced cells to adopt an MMP-dependent mechanism of invasion. In cells expressing ectopic Snail, invasion became sensitive to the MMP inhibitor Ro 28-2653 and insensitive to the ROCK inhibitor Y27632, suggesting that, once induced by Snail, the mesenchymal movement prevails over the amoeboid one. Snail-expressing cells had a more aggressive behavior in vivo, and exhibited increased tumor growth rate and metastatic ability. These results confirm the high plasticity of cancer cells, which can adopt different types of movement in response to changes in the expression of specific genes. Furthermore, the present findings indicate that Rnd3 and Snail are possible regulators of the type of invasion mechanism adopted by mesenchymal tumor cells.

  7. Chemical and mechanical control of corrosion product transport

    Energy Technology Data Exchange (ETDEWEB)

    Hede Larsen, O.; Blum, R. [I/S Fynsvaerket, Faelleskemikerne, Odense (Denmark); Daucik, K. [I/S Skaerbaekvaerket, Faelleskemikerne, Fredericia (Denmark)


    The corrosion products formed in the condensate and feedwater system of once-through boilers are precipitated and deposited inside the evaporator tubes mainly in the burner zone at the highest heat flux. Depositions lead to increased oxidation rate and increased metal temperature of the evaporator tubes, hereby decreasing tube lifetime. This effect is more important in the new high efficiency USC boilers due to increased feedwater temperature and hence higher thermal load on the evaporator tubes. The only way to reduce the load on the evaporator tubes is to minimise corrosion product transport to the boiler. Two general methods for minimising corrosion product transport to the boiler have been evaluated through measurement campaigns for Fe in the water/steam cycle in supercritical boilers within the ELSAM area. One method is to reduce corrosion in the low temperature condensate system by changing conditioning mode from alkaline volatile treatment (AVT) to oxygenated treatment (OT). The other method is to filtrate part of the condensate with a mechanical filter at the deaerator. The results show, that both methods are effective at minimising Fe-transport to the boiler, but changing to OT has the highest effect and should always be used, whenever high purity condensate is maintained. Whether mechanical filtration also is required, depends on the boiler, specifically the load on the evaporator. A simplified calculation model for lifetime evaluation of evaporator tubes has been developed. This model has been used for evaluating the effect of corrosion product transport to the boiler on evaporator tube lifetime. Conventional supercritical boilers generally can achieve sufficient lifetime by AVT and even better by OT, whereas all measures to reduce Fe-content of feedwater, including OT and mechanical filtration, should be taken, to ensure sufficient lifetime for the new boilers with advanced steam data - 290 bar/580 deg. C and above. (au)

  8. Mechanical control over valley magnetotransport in strained graphene (United States)

    Ma, Ning; Zhang, Shengli; Liu, Daqing


    Recent experiments report that the graphene exhibits Landau levels (LLs) that form in the presence of a uniform strain pseudomagnetic field with magnitudes up to hundreds of tesla. We further reveal that the strain removes the valley degeneracy in LLs, and leads to a significant valley polarization with inversion symmetry broken. This accordingly gives rise to the well separated valley Hall plateaus and Shubnikov-de Haas oscillations. These effects are absent in strainless graphene, and can be used to generate and detect valley polarization by mechanical means, forming the basis for the new paradigm "valleytronics" applications.

  9. Intermediate filaments: a dynamic network that controls cell mechanics. (United States)

    Gruenbaum, Yosef; Aebi, Ueli


    In humans the superfamily of intermediate filament (IF) proteins is encoded by more than 70 different genes, which are expressed in a cell- and tissue-specific manner. IFs assemble into approximately 10 nm-wide filaments that account for the principal structural elements at the nuclear periphery, nucleoplasm, and cytoplasm. They are also required for organizing the microtubule and microfilament networks. In this review, we focus on the dynamics of IFs and how modifications regulate it. We also discuss the role of nuclear IF organization in determining nuclear mechanics as well as that of cytoplasmic IFs organization in maintaining cell stiffness, formation of lamellipodia, regulation of cell migration, and permitting cell adhesion.

  10. [Control of fertilization by self-incompatibility mechanisms]. (United States)

    Fobis-Loisy, Isabelle; Gaude, Thierry


    Flowering plants (angiosperms) are the most prevalent and evolutionarily advanced group of plants. Reproductive strategies that promote cross-fertilization have played an essential role in the success of angiosperms as they contribute to genetic variability among plant species. A major genetic barrier to self-fertilization is self-incompatibility (SI), which allows female reproductive cells to discriminate between self- and non-self pollen and specifically reject self-pollen. In this review, we describe three SI mechanisms showing that different flowering plant families use distinct molecules for recognition of self as well as diverse biochemical pathways to arrest pollen tube growth.

  11. Human skeletal muscle behavior in vivo: Finite element implementation, experiment, and passive mechanical characterization. (United States)

    Clemen, Christof B; Benderoth, Günther E K; Schmidt, Andreas; Hübner, Frank; Vogl, Thomas J; Silber, Gerhard


    In this study, useful methods for active human skeletal muscle material parameter determination are provided. First, a straightforward approach to the implementation of a transversely isotropic hyperelastic continuum mechanical material model in an invariant formulation is presented. This procedure is found to be feasible even if the strain energy is formulated in terms of invariants other than those predetermined by the software's requirements. Next, an appropriate experimental setup for the observation of activation-dependent material behavior, corresponding data acquisition, and evaluation is given. Geometry reconstruction based on magnetic resonance imaging of different deformation states is used to generate realistic, subject-specific finite element models of the upper arm. Using the deterministic SIMPLEX optimization strategy, a convenient quasi-static passive-elastic material characterization is pursued; the results of this approach used to characterize the behavior of human biceps in vivo indicate the feasibility of the illustrated methods to identify active material parameters comprising multiple loading modes. A comparison of a contact simulation incorporating the optimized parameters to a reconstructed deformed geometry of an indented upper arm shows the validity of the obtained results regarding deformation scenarios perpendicular to the effective direction of the nonactivated biceps. However, for a valid, activatable, general-purpose material characterization, the material model needs some modifications as well as a multicriteria optimization of the force-displacement data for different loading modes.

  12. Characterization of a dielectric barrier discharge in controlled atmosphere (United States)

    Kogelheide, Friederike; Offerhaus, Björn; Bibinov, Nikita; Bracht, Vera; Smith, Ryan; Lackmann, Jan-Wilm; Awakowicz, Peter; Stapelmann, Katharina; Bimap Team; Aept Team


    Non-thermal atmospheric-pressure plasmas are advantageous for various biomedical applications as they make a contact- and painless therapy possible. Due to the potential medical relevance of such plasma sources further understanding of the chemical and physical impact on biological tissue regarding the efficacy and health-promoting effect is necessary. The knowledge of properties and effects offers the possibility to configure plasmas free of risk for humans. Therefore, tailoring the discharge chemistry in regard to resulting oxidative and nitrosative effects on biological tissue by adjusting different parameters is of growing interest. In order to ensure stable conditions for the characterization of the discharge, the used dielectric barrier discharge was mounted in a vessel. Absolutely calibrated optical emission spectroscopy was carried out to analyze the electron density and the reduced electric field. The rather oxygen-based discharge was tuned towards a more nitrogen-based discharge by adjusting several parameters as reactive nitrogen species are known to promote wound healing. Furthermore, the impact of an ozone-free discharge has to be studied. This work was funded by the German Research Foundation (DFG) with the packet grant PAK 816 `Plasma Cell Interaction in Dermatology'.

  13. Review of bioaerosols in indoor environment with special reference to sampling, analysis and control mechanisms. (United States)

    Ghosh, Bipasha; Lal, Himanshu; Srivastava, Arun


    Several tiny organisms of various size ranges present in air are called airborne particles or bioaerosol which mainly includes live or dead fungi and bacteria, their secondary metabolites, viruses, pollens, etc. which have been related to health issues of human beings and other life stocks. Bio-terror attacks in 2001 as well as pandemic outbreak of flue due to influenza A H1N1 virus in 2009 have alarmed us about the importance of bioaerosol research. Hence characterization i.e. identification and quantification of different airborne microorganisms in various indoor environments is necessary to identify the associated risks and to establish exposure threshold. Along with the bioaerosol sampling and their analytical techniques, various literatures revealing the concentration levels of bioaerosol have been mentioned in this review thereby contributing to the knowledge of identification and quantification of bioaerosols and their different constituents in various indoor environments (both occupational and non-occupational sections). Apart from recognition of bioaerosol, developments of their control mechanisms also play an important role. Hence several control methods have also been briefly reviewed. However, several individual levels of efforts such as periodic cleaning operations, maintenance activities and proper ventilation system also serve in their best way to improve indoor air quality.

  14. Mechanisms of TSC-mediated control of synapse assembly and axon guidance.

    Directory of Open Access Journals (Sweden)

    Sarah Knox

    Full Text Available Tuberous sclerosis complex is a dominant genetic disorder produced by mutations in either of two tumor suppressor genes, TSC1 and TSC2; it is characterized by hamartomatous tumors, and is associated with severe neurological and behavioral disturbances. Mutations in TSC1 or TSC2 deregulate a conserved growth control pathway that includes Ras homolog enriched in brain (Rheb and Target of Rapamycin (TOR. To understand the function of this pathway in neural development, we have examined the contributions of multiple components of this pathway in both neuromuscular junction assembly and photoreceptor axon guidance in Drosophila. Expression of Rheb in the motoneuron, but not the muscle of the larval neuromuscular junction produced synaptic overgrowth and enhanced synaptic function, while reductions in Rheb function compromised synapse development. Synapse growth produced by Rheb is insensitive to rapamycin, an inhibitor of Tor complex 1, and requires wishful thinking, a bone morphogenetic protein receptor critical for functional synapse expansion. In the visual system, loss of Tsc1 in the developing retina disrupted axon guidance independently of cellular growth. Inhibiting Tor complex 1 with rapamycin or eliminating the Tor complex 1 effector, S6 kinase (S6k, did not rescue axon guidance abnormalities of Tsc1 mosaics, while reductions in Tor function suppressed those phenotypes. These findings show that Tsc-mediated control of axon guidance and synapse assembly occurs via growth-independent signaling mechanisms, and suggest that Tor complex 2, a regulator of actin organization, is critical in these aspects of neuronal development.

  15. Characterization of a Recoverable Flight Control Computer System (United States)

    Malekpour, Mahyar; Torres, Wilfredo


    The design and development of a Closed-Loop System to study and evaluate the performance of the Honeywell Recoverable Computer System (RCS) in electromagnetic environments (EME) is presented. The development of a Windows-based software package to handle the time-critical communication of data and commands between the RCS and flight simulation code in real-time while meeting the stringent hard deadlines is also submitted. The performance results of the RCS and characteristics of its upset recovery scheme while exercising flight control laws under ideal conditions as well as in the presence of electromagnetic fields are also discussed.

  16. Molecular Alignment and Orientation From Laser-Induced Mechanisms to Optimal Control

    CERN Document Server

    Atabek, O


    Genetic algorithms, as implemented in optimal control strategies, are currently successfully exploited in a wide range of problems in molecular physics. In this context, laser control of molecular alignment and orientation remains a very promising issue with challenging applications extending from chemical reactivity to nanoscale design. We emphasize the complementarity between basic quantum mechanisms monitoring alignment/orientation processes and optimal control scenarios. More explicitly, if on one hand we can help the optimal control scheme to take advantage of such mechanisms by appropriately building the targets and delineating the parameter sampling space, on the other hand we expect to learn, from optimal control results, some robust and physically sound dynamical mechanisms. We present basic mechanisms for alignment and orientation, such as pendular states accommodated by the molecule-plus-field effective potential and the "kick" mechanism obtained by a sudden excitation. Very interestingly, an optim...

  17. Mechanical characterization and structural analysis of recycled fiber-reinforced-polymer resin-transfer-molded beams (United States)

    Tan, Eugene Wie Loon


    The present investigation was focussed on the mechanical characterization and structural analysis of resin-transfer-molded beams containing recycled fiber-reinforced polymers. The beams were structurally reinforced with continuous unidirectional glass fibers. The reinforcing filler materials consisted entirely of recycled fiber-reinforced polymer wastes (trim and overspray). The principal resin was a 100-percent dicyclo-pentadiene unsaturated polyester specially formulated with very low viscosity for resin transfer molding. Variations of the resin transfer molding technique were employed to produce specimens for material characterization. The basic materials that constituted the structural beams, continuous-glass-fiber-reinforced, recycled-trim-filled and recycled-overspray-filled unsaturated polyesters, were fully characterized in axial and transverse compression and tension, and inplane and interlaminar shear, to ascertain their strengths, ultimate strains, elastic moduli and Poisson's ratios. Experimentally determined mechanical properties of the recycled-trim-filled and recycled-overspray-filled materials from the present investigation were superior to those of unsaturated polyester polymer concretes and Portland cement concretes. Mechanical testing and finite element analyses of flexure (1 x 1 x 20 in) and beam (2 x 4 x 40 in) specimens were conducted. These structurally-reinforced specimens were tested and analyzed in four-point, third-point flexure to determine their ultimate loads, maximum fiber stresses and mid-span deflections. The experimentally determined load capacities of these specimens were compared to those of equivalent steel-reinforced Portland cement concrete beams computed using reinforced concrete theory. Mechanics of materials beam theory was utilized to predict the ultimate loads and mid-span deflections of the flexure and beam specimens. However, these predictions proved to be severely inadequate. Finite element (fracture propagation

  18. Control of distributed heat transfer mechanisms in membrane distillation plants

    KAUST Repository

    Laleg-Kirati, Taous-Meriem


    Various examples are provided that are related to boundary control in membrane distillation (MD) processes. In one example, a system includes a membrane distillation (MD) process comprising a feed side and a permeate side separated by a membrane boundary layer; and processing circuitry configured to control a water production rate of the MD process based at least in part upon a distributed heat transfer across the membrane boundary layer. In another example, a method includes determining a plurality of estimated temperature states of a membrane boundary layer separating a feed side and a permeate side of a membrane distillation (MD) process; and adjusting inlet flow rate or inlet temperature of at least one of the feed side or the permeate side to maintain a difference temperature along the membrane boundary layer about a defined reference temperature based at least in part upon the plurality of estimated temperature states.

  19. Sexual orientation biases attentional control: a possible gaydar mechanism

    Directory of Open Access Journals (Sweden)

    Lorenza S Colzato


    Full Text Available Homosexuals are believed to have a “sixth sense” for recognizing each other, an ability referred to as gaydar. We considered that being a homosexual might rely on systematic practice of processing relatively specific, local perceptual features, which might lead to a corresponding chronic bias of attentional control. This was tested by comparing male and female homosexuals and heterosexuals--brought up in the same country and culture and matched in terms of race, intelligence, sex, mood, age, personality, religious background, educational style, and socio-economic situation--in their efficiency to process global and local features of hierarchically-constructed visual stimuli. Both homosexuals and heterosexuals showed better performance on global features—the standard global precedence effect. However, this effect was significantly reduced in homosexuals, suggesting a relative preference for detail. Findings are taken to demonstrate chronic, generalized biases in attentional control parameters that reflect the selective reward provided by the respective sexual orientation.

  20. An Iris Mechanism Driven Temperature Control of Solar Thermal Reactors


    Van den Langenbergh, Lode; Ophoff, Cédric; Ozalp, Nesrin


    In spite of their attraction for clean production of fuels and commodities; solar thermal reactors are challenged by the transient nature of solar energy. Control of reactor temperature during transient periods is the key factor to maintain solar reactor performance. Currently, there are few techniques that are being used to accommodate the fluctuations of incoming solar radiation. One of the commonly practiced methods is to adjust the mass flow rate of the feedstock which is very simple to i...

  1. Controlled Mechanical Cracking of Metal Films Deposited on Polydimethylsiloxane (PDMS

    Directory of Open Access Journals (Sweden)

    Andreas Polywka


    Full Text Available Stretchable large area electronics conform to arbitrarily-shaped 3D surfaces and enables comfortable contact to the human skin and other biological tissue. There are approaches allowing for large area thin films to be stretched by tens of percent without cracking. The approach presented here does not prevent cracking, rather it aims to precisely control the crack positions and their orientation. For this purpose, the polydimethylsiloxane (PDMS is hardened by exposure to ultraviolet radiation (172 nm through an exposure mask. Only well-defined patterns are kept untreated. With these soft islands cracks at the hardened surface can be controlled in terms of starting position, direction and end position. This approach is first investigated at the hardened PDMS surface itself. It is then applied to conductive silver films deposited from the liquid phase. It is found that statistical (uncontrolled cracking of the silver films can be avoided at strain below 35%. This enables metal interconnects to be integrated into stretchable networks. The combination of controlled cracks with wrinkling enables interconnects that are stretchable in arbitrary and changing directions. The deposition and patterning does not involve vacuum processing, photolithography, or solvents.

  2. Molecular Mechanisms to Control Post-Transplantation Hepatitis B Recurrence

    Directory of Open Access Journals (Sweden)

    Akinobu Takaki


    Full Text Available Hepatitis B often progresses to decompensated liver cirrhosis requiring orthotopic liver transplantation (OLT. Although newer nucleos(tide analogues result in >90% viral and hepatitis activity control, severely decompensated patients still need OLT because of drug-resistant virus, acute exacerbation, or hepatocellular carcinoma. Acute hepatitis B is also an indication for OLT, because it can progress to fatal acute liver failure. After OLT, the hepatitis B recurrence rate is >80% without prevention, while >90% of transplant recipients are clinically controlled with combined hepatitis B immunoglobulin (HBIG and nucleos(tide analogue treatment. However, long-term HBIG administration is associated with several unresolved issues, including limited availability and extremely high cost; therefore, several treatment protocols with low-dose HBIG, combined with nucleos(tide analogues, have been investigated. Another approach is to induce self-producing anti-hepatitis B virus (HBV antibodies using an HBV envelope (HBs antigen vaccine. Patients who are not HBV carriers, such as those with acutely infected liver failure, are good candidates for vaccination. For chronic HBV carrier liver cirrhosis patients, a successful vaccine response can only be achieved in selected patients, such as those treated with experimentally reduced immunosuppression protocols. The present protocol for post-OLT HBV control and the future prospects of newer treatment strategies are reviewed.

  3. Advanced Branching Control and Characterization of Inorganic Semiconducting Nanocrystals

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, Steven Michael [Univ. of California, Berkeley, CA (United States)


    The ability to finely tune the size and shape of inorganic semiconducting nanocrystals is an area of great interest, as the more control one has, the more applications will be possible for their use. The first two basic shapes develped in nanocrystals were the sphere and the anistropic nanorod. the II_VI materials being used such as Cadmium Selenide (CdSe) and Cadmium Telluride (CdTe), exhibit polytypism, which allows them to form in either the hexagonally packed wurtzite or cubically packed zinc blende crystalline phase. The nanorods are wurtzite with the length of the rod growing along the c-axis. As this grows, stacking faults may form, which are layers of zinc blende in the otherwise wurtzite crystal. Using this polytypism, though, the first generation of branched crystals were developed in the form of the CdTe tetrapod. This is a nanocrystal that nucleates in the zincblend form, creating a tetrahedral core, on which four wurtzite arms are grown. This structure opened up the possibility of even more complex shapes and applications. This disseration investigates the advancement of branching control and further understanding the materials polytypism in the form of the stacking faults in nanorods.

  4. Eleventh symposium on energy engineering sciences: Proceedings. Solid mechanics and processing: Analysis, measurement and characterization

    Energy Technology Data Exchange (ETDEWEB)


    The Eleventh Symposium on Energy Engineering Sciences was held on May 3--5, 1993, at the Argonne National Laboratory, Argonne, Illinois. These proceedings include the program, list of participants, and the papers that were presented during the eight technical sessions held at this meeting. This symposium was organized into eight technical sessions: Surfaces and interfaces; thermophysical properties and processes; inelastic behavior; nondestructive characterization; multiphase flow and thermal processes; optical and other measurement systems; stochastic processes; and large systems and control. Individual projects were processed separately for the databases.

  5. Characterization of Al–Al{sub 4}C{sub 3} nanocomposites produced by mechanical milling

    Energy Technology Data Exchange (ETDEWEB)

    Santos-Beltrán, A., E-mail: [Universidad Tecnológica de Chihuahua Sur, Carr. Chihuahua a Aldama km. 3 S/N, Col. Colinas del León, CP. 31313 Chihuahua, Chih. (Mexico); Goytia-Reyes, R. [Centro de Investigación en Materiales Avanzados (CIMAV), Laboratorio Nacional de Nanotecnología, Miguel de Cervantes No. 120, C.P. 31109 Chihuahua, Chih. (Mexico); Morales-Rodriguez, H.; Gallegos-Orozco, V. [Universidad Tecnológica de Chihuahua Sur, Carr. Chihuahua a Aldama km. 3 S/N, Col. Colinas del León, CP. 31313 Chihuahua, Chih. (Mexico); Santos-Beltrán, M. [Centro de Investigación en Materiales Avanzados (CIMAV), Laboratorio Nacional de Nanotecnología, Miguel de Cervantes No. 120, C.P. 31109 Chihuahua, Chih. (Mexico); Baldenebro-Lopez, F. [Universidad Tecnológica de Chihuahua Sur, Carr. Chihuahua a Aldama km. 3 S/N, Col. Colinas del León, CP. 31313 Chihuahua, Chih. (Mexico); Martínez-Sánchez, R. [Centro de Investigación en Materiales Avanzados (CIMAV), Laboratorio Nacional de Nanotecnología, Miguel de Cervantes No. 120, C.P. 31109 Chihuahua, Chih. (Mexico)


    In this work, a mixture of Al–C–Al{sub 4}C{sub 3} nanopowder previously synthesized by mechanical milling and subsequent thermal treatment was used to reinforce the Al matrix. The nanocomposites were fabricated via high-energy ball milling and subsequent sintering process for different periods of time at 550 °C. Hardness and compression tests were performed to evaluate the mechanical properties of the nanocomposites in the as-milled and sintered conditions. According to the results the reinforcement located in the grain boundaries is responsible for the brittle behavior observed in the nanocomposites during the compression test. The combined effect of sintering and precipitation mechanisms produced an evident increase of the strength of the Al matrix at a relatively short sintering time. By using the Rietveld method the crystallite size and microstrain measurements were determined and correlated with the microhardness values. For the proper characterization of the nanoparticles present in the Al matrix, atomic force microscopy and high resolution electron microscopy were used. - Highlights: • Nanostructured Al{sub 4}C{sub 3} reinforcement was fabricated via mechanical milling and heat treatment. • We found a significant increase of the mechanical properties at short sintering times. • The formation of Al{sub 4}C{sub 3} with during sintering time restricted the excessive growth of the crystallite. • Al{sub 4}C{sub 3} located in the grain boundaries causes brittle fracture observed in compression tests. • There is a correlation between, crystallite size and microstrain values with microhardness.

  6. Development of passive-controlled HUB (teetered brake & damper mechanism) of horizontal axis wind turbine

    Energy Technology Data Exchange (ETDEWEB)

    Shimizu, Yukimaru; Kamada, Yasunari; Maeda, Takao [Mie Univ. (Japan)


    For the purpose of the improvement of reliability of the Mega-Watt wind turbine, this paper indicates the development of an original mechanism for the passive-controlled hub, which has the effects of braking and damping on aerodynamic forces. This mechanism is useful for variable speed control of the large wind turbine. The passive-controlled hub is the combination of two mechanisms. One is the passive-teetered and damping mechanism, and the other is the passive-variable-pitch mechanism. These mechanism are carried out by the combination of the teetering and feathering motions. When the wind speed exceeds the rated wind speed, the blade is passively teetered in a downwind direction and, simultaneously, a feathering mechanism, which is linked to the teetering mechanism through a connecting rods, is activated. Testing of the model horizontal axis wind turbine in a wind tunnel showed that the passive-controlled hub mechanism can suppress the over-rotational speed of the rotor. By the application of the passive-controlled hub mechanism, the maximum rotor speed is reduced to about 60%.

  7. Deep brain stimulation mechanisms: the control of network activity via neurochemistry modulation. (United States)

    McIntyre, Cameron C; Anderson, Ross W


    Deep brain stimulation (DBS) has revolutionized the clinical care of late-stage Parkinson's disease and shows promise for improving the treatment of intractable neuropsychiatric disorders. However, after over 25 years of clinical experience, numerous questions still remain on the neurophysiological basis for the therapeutic mechanisms of action. At their fundamental core, the general purpose of electrical stimulation therapies in the nervous system are to use the applied electric field to manipulate the opening and closing of voltage-gated sodium channels on neurons, generate stimulation induced action potentials, and subsequently, control the release of neurotransmitters in targeted pathways. Historically, DBS mechanisms research has focused on characterizing the effects of stimulation on neurons and the resulting impact on neuronal network activity. However, when electrodes are placed within the central nervous system, glia are also being directly (and indirectly) influenced by the stimulation. Mounting evidence shows that non-neuronal tissue can play an important role in modulating the neurochemistry changes induced by DBS. The goal of this review is to evaluate how DBS effects on both neuronal and non-neuronal tissue can potentially work together to suppress oscillatory activity (and/or information transfer) between brain regions. These resulting effects of ~ 100 Hz electrical stimulation help explain how DBS can disrupt pathological network activity in the brain and generate therapeutic effects in patients. Deep brain stimulation is an effective clinical technology, but detailed therapeutic mechanisms remain undefined. This review provides an overview of the leading hypotheses, which focus on stimulation-induced disruption of network oscillations and integrates possible roles for non-neuronal tissue in explaining the clinical response to therapeutic stimulation. This article is part of a special issue on Parkinson disease.

  8. Mechanisms of surgical control of type 2 diabetes

    DEFF Research Database (Denmark)

    Holst, Jens Juul; Madsbad, Sten


    GLP-1 secretion in response to meals is dramatically increased after gastric bypass operations. GLP-1 is a powerful insulinotropic and anorectic hormone, and analogs of GLP-1 are widely used for the treatment of diabetes and recently approved also for obesity treatment. It is, therefore, reasonable...... of the operation, is reduced and or abolished after GLP-1 receptor blockade. Also the postoperative improvement of glucose tolerance is eliminated and or reduced by the antagonist, pointing to a key role for the exaggerated GLP-1 secretion. Indeed, there is evidence that the exaggerated GLP-1 secretion is also...... responsible for postprandial hypoglycemia sometimes observed after bypass. Other operations (biliopancreatic-diversion and or sleeve gastrectomy) appear to involve different and/or additional mechanisms, and so does experimental bariatric surgery in rodents. However, unlike bypass surgery in humans...

  9. Sonolytic degradation of dimethoate: kinetics, mechanisms and toxic intermediates controlling. (United States)

    Yao, Juan-Juan; Hoffmann, Michael R; Gao, Nai-Yun; Zhang, Zhi; Li, Lei


    The sonolytic degradation of aqueous solutions of dimethoate, O,O-dimethyl S-[2-(methylamino)-2-oxoethyl]dithiophosphate, was examined. Optimal degradation rates were obtained at 619 kHz for continuous sonolysis and 406 kHz for pulse sonolysis. The primary pathways for degradation include hydroxyl radical oxidation, hydrolysis and pyrolysis on collapsing cavitation bubble interfaces. Reaction mechanisms coupled with the corresponding kinetic models are proposed to reproduce the observed concentration versus time profiles for dimethoate, omethoate and N-(methyl) mercaptoacetamide during sonolysis. The oxidation and hydrolysis of dimethoate and omethoate occurred at the water-bubble interface was the rate-determining step for sonolytic overall degradation of dimethoate. More than 90% toxicity of dimethoate was reduced within 45 min ultrasonic irradiation. Ferrous ion at micro molar level can significantly enhance the sonolytic degradation of dimethoate and effectively reduce the yields of toxic intermediate omethoate.

  10. Factors controlling alkalisalt deposition in recovery boiler- release mechanisms

    Energy Technology Data Exchange (ETDEWEB)

    McKeough, P.; Kylloenen, H.; Kurkela, M. [VTT Energy, Espoo (Finland). Process Technology Group


    As part of a cooperative effort to develop a model to describe the behaviour of inorganic compounds in kraft recovery boilers, an experimental investigation of the release of sulphur during black liquor pyrolysis has been undertaken. Previous to these studies, the mechanisms of sulphur release and the reasons for the observed effects of process conditions on sulphur release were very poorly understood. On the basis of the experimental results, the main reactions leading to sulphur release have been elucidated with a fair degree of certainty. Logical explanations for the variations of sulphur release with temperature and with liquor solids content have been proposed. The influence of pressure has been investigated in order to gain insights into the effects of mass transfer on the sulphur-release rate. In the near future, the research will be aimed at generating the kinetic data necessary for modelling the release of sulphur in the recovery furnace. (author)

  11. Chemical, Physical, and Mechanical Characterization of Isocyanate Cross-linked Amine-Modified Silica Aerogels (United States)

    Katti, Atul; Shimpi, Nilesh; Roy, Samit; Lu, Hongbing; Fabrizio, Eve F.; Dass, Amala; Capadona, Lynn A.; Leventis, Nicholas


    We describe a new mechanically strong lightweight porous composite material obtained by encapsulating the skeletal framework of amine-modified silica aerogels with polyurea. The conformal polymer coating preserves the mesoporous structure of the underlying silica framework and the thermal conductivity remains low at 0.041 plus or minus 0.001 W m(sup -1 K(sup -1). The potential of the new cross-linked silica aerogels for load-carrying applications was determined through characterization of their mechanical behavior under compression, three-point bending, and dynamic mechanical analysis (DMA). A primary glass transition temperature of 130 C was identified through DMA. At room temperature, results indicate a hyperfoam behavior where in compression cross-linked aerogels are linearly elastic under small strains (less than 4%) and then exhibit yield behavior (until 40% strain), followed by densification and inelastic hardening. At room temperature the compressive Young's modulus and the Poisson's ratio were determined to be 129 plus or minus 8 MPa and 0.18, respectively, while the strain at ultimate failure is 77% and the average specific compressive stress at ultimate failure is 3.89 x 10(exp 5) N m kg(sup -1). The specific flexural strength is 2.16 x 10(exp 4) N m kg(sup -1). Effects on the compressive behavior of strain rate and low temperature were also evaluated.

  12. Mechanical modeling of battery separator based on microstructure image analysis and stochastic characterization (United States)

    Xu, Hongyi; Zhu, Min; Marcicki, James; Yang, Xiao Guang


    A microstructure-based modeling method is developed to predict the mechanical behaviors of lithium-ion battery separators. Existing battery separator modeling methods cannot capture the structural features on the microscale. To overcome this issue, we propose an image-based microstructure Representative Volume Element (RVE) modeling method, which facilitates the understanding of the separators' complex macro mechanical behaviors from the perspective of microstructural features. A generic image processing workflow is developed to identify different phases in the microscopic image. The processed RVE image supplies microstructural information to the Finite Element Analysis (FEA). Both mechanical behavior and microstructure evolution are obtained from the simulation. The evolution of microstructure features is quantified using the stochastic microstructure characterization methods. The proposed method successfully captures the anisotropic behavior of the separator under tensile test, and provides insights into the microstructure deformation, such as the growth of voids. We apply the proposed method to a commercially available separator as the demonstration. The analysis results are validated using experimental testing results that are reported in literature.

  13. A Review on Congestion control Mechanisms in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    N. Thrimoorthy


    Full Text Available Recently, Wireless Sensor Networks (WSNs have been in many applications and systems with vastly varying requirements and characteristics. Due to this, it would be difficult to decide the requirements regarding hardware issues and software support. Heterogeneous applications can be integrated within the same wireless sensor network with the aid of modern motes that have multiple sensors on a single radio board. Considering such multi-purpose nodes, different types of data could be generated from such types of motes with many transmission characteristics in terms of priority, transmission rate, required bandwidth, tolerable packet loss, delay demands etc. WSNs have many different constraints, such as computational power, storage capacity, energy supply and the most important issue is their energy constraint. Energy aware routing protocol is very important in WSN, but only considering energy has no efficiency in performance. Congestion in WSNs is one of the critical problems still from its evolution. Congestion causes malfunctions such as packet loss, lower throughput, energy efficiency, increase in collisions, increase in queuing delay and decreased network lifetime. As a result, the performance of the whole network is subject to undesirable and unpredictable changes. In this paper, WSN performance control by robust Congestion control approaches that aim to keep the network operational under varying network conditions is presented.

  14. Mechanisms controlling anaemia in Trypanosoma congolense infected mice.

    Directory of Open Access Journals (Sweden)

    Harry A Noyes

    Full Text Available BACKGROUND: Trypanosoma congolense are extracellular protozoan parasites of the blood stream of artiodactyls and are one of the main constraints on cattle production in Africa. In cattle, anaemia is the key feature of disease and persists after parasitaemia has declined to low or undetectable levels, but treatment to clear the parasites usually resolves the anaemia. METHODOLOGY/PRINCIPAL FINDINGS: The progress of anaemia after Trypanosoma congolense infection was followed in three mouse strains. Anaemia developed rapidly in all three strains until the peak of the first wave of parasitaemia. This was followed by a second phase, characterized by slower progress to severe anaemia in C57BL/6, by slow recovery in surviving A/J and a rapid recovery in BALB/c. There was no association between parasitaemia and severity of anaemia. Furthermore, functional T lymphocytes are not required for the induction of anaemia, since suppression of T cell activity with Cyclosporin A had neither an effect on the course of infection nor on anaemia. Expression of genes involved in erythropoiesis and iron metabolism was followed in spleen, liver and kidney tissues in the three strains of mice using microarrays. There was no evidence for a response to erythropoietin, consistent with anaemia of chronic disease, which is erythropoietin insensitive. However, the expression of transcription factors and genes involved in erythropoiesis and haemolysis did correlate with the expression of the inflammatory cytokines Il6 and Ifng. CONCLUSIONS/SIGNIFICANCE: The innate immune response appears to be the major contributor to the inflammation associated with anaemia since suppression of T cells with CsA had no observable effect. Several transcription factors regulating haematopoiesis, Tal1, Gata1, Zfpm1 and Klf1 were expressed at consistently lower levels in C57BL/6 mice suggesting that these mice have a lower haematopoietic capacity and therefore less ability to recover from

  15. Barchan dune corridors: Field characterization and investigation of control parameters (United States)

    Elbelrhiti, H.; Andreotti, B.; Claudin, P.


    The structure of the barchan field located between Tarfaya and Laayoune (Atlantic Sahara, Morocco) is quantitatively investigated and compared to that in La Pampa de la Joya (Arequipa, Peru). On the basis of field measurements, we show how the volume, the velocity, and the output sand flux of a dune can be computed from the value of its body and horn widths. The dune size distribution is obtained from the analysis of aerial photographs. It shows that these fields are in a statistically homogeneous state along the wind direction and present a "corridor" structure in the transverse direction, in which the dunes have a rather well selected size. Investigating the possible external parameters controlling these corridors, we demonstrate that none among topography, granulometry, wind, and sand flux is relevant. We finally discuss the dynamical processes at work in these fields (collisions and wind fluctuations) and investigate the way they could regulate the size of the dunes. Furthermore, we show that the overall sand flux transported by a dune field is smaller than the maximum transport that could be reached in the absence of dunes, i.e., in saltation over the solid ground.

  16. Radial basis function (RBF) neural network control for mechanical systems design, analysis and Matlab simulation

    CERN Document Server

    Liu, Jinkun


    Radial Basis Function (RBF) Neural Network Control for Mechanical Systems is motivated by the need for systematic design approaches to stable adaptive control system design using neural network approximation-based techniques. The main objectives of the book are to introduce the concrete design methods and MATLAB simulation of stable adaptive RBF neural control strategies. In this book, a broad range of implementable neural network control design methods for mechanical systems are presented, such as robot manipulators, inverted pendulums, single link flexible joint robots, motors, etc. Advanced neural network controller design methods and their stability analysis are explored. The book provides readers with the fundamentals of neural network control system design.   This book is intended for the researchers in the fields of neural adaptive control, mechanical systems, Matlab simulation, engineering design, robotics and automation. Jinkun Liu is a professor at Beijing University of Aeronautics and Astronauti...

  17. Repetitive control mechanism of disturbance cancellation using a hybrid regression and genetic algorithm (United States)

    Lin, Jeng-Wen; Shen, Pu Fun; Wen, Hao-Ping


    The application of a repetitive control mechanism for use in a mechanical control system has been a topic of investigation. The fundamental purpose of repetitive control is to eliminate disturbances in a mechanical control system. This paper presents two different repetitive control laws using individual types of basis function feedback and their combinations. These laws adjust the command given to a feedback control system to eliminate tracking errors, generally resulting from periodic disturbance. Periodic errors can be reduced through linear basis functions using regression and a genetic algorithm. The results illustrate that repetitive control is most effective method for eliminating disturbances. When the data are stabilized, the tracking error of the obtained convergence value, 10-14, is the optimal solution, verifying that the proposed regression and genetic algorithm can satisfactorily reduce periodic errors.

  18. Barrier Lyapunov function-based model-free constraint position control for mechanical systems

    Energy Technology Data Exchange (ETDEWEB)

    Han, Seong Ik; Ha, Hyun Uk; Lee, Jang Myung [Pusan National University, Busan (Korea, Republic of)


    In this article, a motion constraint control scheme is presented for mechanical systems without a modeling process by introducing a barrier Lyapunov function technique and adaptive estimation laws. The transformed error and filtered error surfaces are defined to constrain the motion tracking error in the prescribed boundary layers. Unknown parameters of mechanical systems are estimated using adaptive laws derived from the Lyapunov function. Then, robust control used the conventional sliding mode control, which give rise to excessive chattering, is changed to finite time-based control to alleviate undesirable chattering in the control action and to ensure finite-time error convergence. Finally, the constraint controller from the barrier Lyapunov function is designed and applied to the constraint of the position tracking error of the mechanical system. Two experimental examples for the XY table and articulated manipulator are shown to evaluate the proposed control scheme.

  19. IGF-loaded silicon and zinc doped brushite cement: physico-mechanical characterization and in vivo osteogenesis evaluation. (United States)

    Vahabzadeh, Sahar; Bandyopadhyay, Amit; Bose, Susmita; Mandal, Rakesh; Nandi, Samit Kumar


    Dopants play critical roles in controlling the physical, mechanical, degradation kinetics, and in vivo properties of calcium phosphates. The aim of the present study was to evaluate the effects of silicon (Si) and zinc (Zn) dopants on the physico-mechanical and in vivo osteogenesis properties of brushite cements (BrCs) alone and in combination with insulin like growth factor 1 (IGF-1). Addition of 0.5 wt% Si did not alter the setting time, β-TCP content, and compressive strength of BrCs significantly; however, 0.25 wt% Zn incorporation was accompanied by a significant decrease in mechanical strength from 4.78 ± 0.21 MPa for pure BrC to 3.78 ± 0.59 MPa and 3.28 ± 0.22 MPa for Zn-BrC and Si/Zn-BrC, respectively. The in vivo bone regeneration properties of doped BrCs alone and in combination with IGF-1 were assessed and compared using chronological radiography, histology, scanning electron microscopy and fluorochrome labeling at 2 and 4 months post implantation in a rabbit femoral defect model. Based on in vivo characterization focusing on osteogenesis and vasculogenesis, Si-BrC and Si/Zn-BrC showed the best performance followed by Zn-BrC and pure BrCs. Addition of IGF-1 further improved bone regeneration. Our findings confirm that addition of Si and/or Zn alters the physico-mechanical properties of BrCs and promotes the early stage in vivo osseointegration and bone remodeling properties.

  20. Characterization and control of Mucor circinelloides spoilage in yogurt. (United States)

    Snyder, Abigail B; Churey, John J; Worobo, Randy W


    Consumer confidence in the food industry is severely affected by large-scale spoilage incidents. However, relatively little research exists on spoilage potential of members of the fungal subphylum Mucormycotina (e.g. Mucor), which includes dimorphic spoilage organisms that can switch between a yeast-like and hyphal phase depending on environmental conditions. The presence of Mucor circinelloides in yogurt may not cause spoilage, but growth and subsequent changes in quality (e.g. container bloating) can cause spoilage if not controlled. The purpose of this study was to evaluate the effects on M. circinelloides of pasteurization regimen, natamycin concentrations, and storage temperature in yogurt production, as measured by fungal proliferation and carbon dioxide production. A strain of M. circinelloides isolated from commercially spoiled yogurt showed greater yogurt-spoilage potential than clinical isolates and other industrial strains. D-values and z-values were determined for the spoilage isolate in milk as an evaluation of the fungus' ability to survive pasteurization. Natamycin was added to yogurt at 0, 5, 10, 15, and 20ppm (μg/ml) to determine its ability to inhibit M. circinelloides over the course of month-long challenge studies at 4°C, 15°C, and 25°C. Survivors were recovered on acidified PDA and carbon dioxide levels were recorded. The D-values at 54°C, 56°C, and 58°C for hyphae/sporangiospores were (in min) 38.31±0.02, 10.17±0.28, and 1.94±0.53, respectively, which yielded a z-value of 3.09°C. The D-values at 51°C, 53°C, and 55°C for yeast-like cells were (in min) 14.25±0.12, 6.87±1.19, and 2.44±0.35, respectively, which yielded a z-value of 0.34°C. These results indicated that M. circinelloides would not survive fluid milk pasteurization if contamination occurred prior to thermal treatment. CO2 production was only observed when M. circinelloides was incubated under low-oxygen conditions, and occurred only at temperatures above 4

  1. Tracking Control of Fully-actuated port-Hamiltonian Mechanical Systems using Sliding Manifolds and Contraction

    NARCIS (Netherlands)

    Reyes Báez, Rodolfo; van der Schaft, Abraham; Jayawardhana, Bayu


    In this paper, we propose a novel trajectory tracking controller for fully-actuated mechanical port-Hamiltonian (pH) systems, which is based on recent advances in contraction- based control theory. Our proposed controller renders a desired sliding manifold (where the reference trajectory lies) attra

  2. Application of Fuzzy-PID Control System in Full-Mechanized Coal Face

    Institute of Scientific and Technical Information of China (English)

    LU Kui; TANG Pei-rong; YANG Wei-min


    The control system, which includes structure, the composition of software and hardware, the form of PID control system and its systematic closed-loop, was used in No.4236 full-mechanized coal face of Xinlongzhuang mine.The typical fuzzy PID control system structure was investigated, and a simplified fuzzy PID control system was taken the place of the complex three-dimension fuzzy controller. Based on the parameter relation between fuzzy controller and normal PID controller, a common method of parameter adjustment of PID controller was summed up and the computer simulation was realized. This system can overcome the problems of large delay, nonlinear, poor running environment and great load change in the full-mechanized coal face. The simulating investigation indicates that the designing method of fuzzy controller is simple and feasible.

  3. Characterization of Wear Mechanisms in Distorted Conical Picks After Coal Cutting (United States)

    Dewangan, Saurabh; Chattopadhyaya, Somnath


    The interest in understanding the wear mechanisms of cemented carbide (CC) is not a new development. For a long time, there have been studies on different wear mechanisms under different coal/rock cutting conditions. These studies have helped improving the quality of CC, thereby preventing such wearing of tools. Due to highly unpredictable character of coal/rock, the wearing phenomena cannot be attributed to one single domain of conditions. However, one conclusion that can be drawn in this context is that, under similar working conditions, similar types of CC undergo similar nature of wearing process. An optimum combination of high wear resistance, strength and hardness has facilitated widespread application of CC in the field of mining engineering. The abrasive parts of the mining tools are made of CC materials. The current study is focussed on a detailed characterization of the wear mechanisms of conical picks, which are used for coal mining. Conical picks consist of a steel body with an inserted cone-shaped CC tip. After being used for a certain period of time, both, the CC tip and the steel body get distorted. In this study, selection of appropriate samples was followed by critical observation of them through field emission scanning electron microscopy (FESEM) and energy dispersive X-ray spectroscopy (EDS). In the previous study, we explained the distortion process of both, the tip as well as the body, using the SEM images. For the present study, two samples were taken from our previous investigation for further analysis. Three other samples were also included in the present study. Seven different types of wear mechanisms, such as, cracking and crushing, cavity formation, coal intermixing, chemical degradation along with abrasion, long and deep cracks, heating effect and body deformation were observed in the five tool samples.

  4. Physical and mechanical characterization of Portland cement mortars made with expanded polystyrene particles addition (EPS

    Directory of Open Access Journals (Sweden)

    Ferrándiz-Mas, V.


    Full Text Available On this work the influence of the addition of different types (commercial and recycled and contents of expanded polystyrene on the physical and mechanical properties of Portland cement mortars has been studied. Variables studied are: workability, air content, bulk density, mechanical strength, porosity, water absorption and sound absorption. Mixtures have been also characterized by scanning electron microscopy. Air-entraining agents, water retainer and superplasticizer additives have been used in order to improve the workability of mortars. The results show that the workability and mechanical strength decreases with increasing content of expanded polystyrene. Additives improve the workability and porosity, allowing manufacture mortars with high levels of recycled material that show mechanical properties suitable for use as masonry mortars, stucco and plaster.

    El objetivo de este estudio es evaluar la influencia de la adición de distintos tipos y dosificaciones de poliestireno expandido, tanto comerciales como procedentes de reciclado, sobre las características físicas y mecánicas de morteros de cemento portland. Las variables estudiadas fueron: consistencia, aire ocluido, densidad aparente, resistencias mecánicas, porosidad, absorción de agua y absorción acústica. Los morteros también se han caracterizado por microscopia electrónica de barrido. Con objeto de mejorar la trabajabilidad de los morteros se ha empleado aditivos aireante, retenedor de agua y fluidificante. Los resultados muestran que al aumentar la cantidad de poliestireno expandido la trabajabilidad y las resistencias mecánicas disminuyen. El empleo de aditivos mejora la trabajabilidad y la porosidad, permitiendo fabricar morteros con altos contenidos de residuo, con propiedades mecánicas adecuadas para su empleo como morteros de albañilería, revoco y enlucido.

  5. An Action-Based Fine-Grained Access Control Mechanism for Structured Documents and Its Application

    Directory of Open Access Journals (Sweden)

    Mang Su


    Full Text Available This paper presents an action-based fine-grained access control mechanism for structured documents. Firstly, we define a describing model for structured documents and analyze the application scenarios. The describing model could support the permission management on chapters, pages, sections, words, and pictures of structured documents. Secondly, based on the action-based access control (ABAC model, we propose a fine-grained control protocol for structured documents by introducing temporal state and environmental state. The protocol covering different stages from document creation, to permission specification and usage control are given by using the Z-notation. Finally, we give the implementation of our mechanism and make the comparisons between the existing methods and our mechanism. The result shows that our mechanism could provide the better solution of fine-grained access control for structured documents in complicated networks. Moreover, it is more flexible and practical.

  6. Block backstepping design of nonlinear state feedback control law for underactuated mechanical systems

    CERN Document Server

    Rudra, Shubhobrata; Maitra, Madhubanti


    This book presents a novel, generalized approach to the design of nonlinear state feedback control laws for a large class of underactuated mechanical systems based on application of the block backstepping method. The control law proposed here is robust against the effects of model uncertainty in dynamic and steady-state performance and addresses the issue of asymptotic stabilization for the class of underactuated mechanical systems. An underactuated system is defined as one for which the dimension of space spanned by the configuration vector is greater than that of the space spanned by the control variables. Control problems concerning underactuated systems currently represent an active field of research due to their broad range of applications in robotics, aerospace, and marine contexts. The book derives a generalized theory of block backstepping control design for underactuated mechanical systems, and examines several case studies that cover interesting examples of underactuated mechanical systems. The math...

  7. Study on Variable Capacity Control Mechanism of Scroll Compressor for Automotive Air Conditioner (United States)

    Hirano, Takahisa; Shigeoka, Tetsuo

    As for the automotive air conditioner, (1) to keep the automotive cabin temperature in a comfortable region, (2) to improve driving feeling, (3) to drive the air conditioning system economically through all seasons, are universally required. Recently, from these points, compressors with variable capacity control mechanism for automotive air conditioners have been remarkably requested. We have developed a scroll comoressor with variable capacity control mechanism. The capacity control mechanism, which changes the channel area of the bypass hole continuously, according to the suction gas pressure and the discharge gas pressure, has been developed. In this report, we describe the mechanism of variable capacity control and the performance simulation program that has been developed for the scroll compressor. Further, we describe the measuring results of cylinder pressure behavior, the results of energy loss analysis and the effect of comfort, drivability, power saving in the refrigerating cycle using the developed capacity control compressor.

  8. Performance Analysis of Novel Overload Control with Threshold Mechanism

    Directory of Open Access Journals (Sweden)

    Doo Il Choi


    Full Text Available We propose a novel overload control method with hysteresis property; that is, we analyze the M/G/1/K queueing system where the service and arrival rates are varied depending on the queue-length. We use two threshold values: L1(≤L2 and L2(≤K. When the queue-length increases by an amount between L1 and L2, we apply one of the following two strategies to reduce the queue-length, either we decrease the mean service time or we decrease the arrival rate. If the queue-length exceeds L2 with one strategy, we apply the other; thus, there are two models that depend on the method that was applied first. We derive the queue-length distribution at departure and at arbitrary epochs using the embedded Markov chain method and the supplementary variable method. We investigate performance measures including the loss probability and mean waiting time using various numerical examples.

  9. Chilean Unremunerated Reserve Requirement Capital Controls as a Screening Mechanism

    Directory of Open Access Journals (Sweden)

    Thomas I. Palley


    Full Text Available Este trabajo presenta un modelo sobre los “speed bump” (topes a los controles de capital de tipo chileno, que los interpreta como un mecanismo para identificar a los inversores volátiles. Esta interpretación es contrastada con la explicación basada en las finanzas poeblicas, cuyo punto de vista muestra a los topes como un impuesto sobre ingresos de capital a corto plazo que incrementan su precio relativo. Un resultado sorprendente es que aun cuando los topes incrementan el costo del capital, ellos pueden realmente incrementar los ingresos de capital. Estos ingresos crecientes son más estables porque provienen de los inversionistas pacientes. La lección es que discriminar a los inversores volátiles estabiliza el ambiente financiero. Los topes benefician tanto a las empresas como a los inversionistas pacientes al reducir el daño que podría provenir de salidas repentinas de capital, lo cual aumenta la demanda y la oferta de capital.

  10. Dissociable mechanisms of cognitive control in prefrontal and premotor cortex. (United States)

    Chambers, Christopher D; Bellgrove, Mark A; Gould, Ian C; English, Therese; Garavan, Hugh; McNaught, Elizabeth; Kamke, Marc; Mattingley, Jason B


    Intelligent behavior depends on the ability to suppress inappropriate actions and resolve interference between competing responses. Recent clinical and neuroimaging evidence has demonstrated the involvement of prefrontal, parietal, and premotor areas during behaviors that emphasize conflict and inhibition. It remains unclear, however, whether discrete subregions within this network are crucial for overseeing more specific inhibitory demands. Here we probed the functional specialization of human prefrontal cortex by combining repetitive transcranial magnetic stimulation (rTMS) with integrated behavioral measures of response inhibition (stop-signal task) and response competition (flanker task). Participants undertook a combined stop-signal/flanker task after rTMS of the inferior frontal gyrus (IFG) or dorsal premotor cortex (dPM) in each hemisphere. Stimulation of the right IFG impaired stop-signal inhibition under conditions of heightened response competition but did not influence the ability to suppress a competing response. In contrast, stimulation of the right dPM facilitated execution but had no effect on inhibition. Neither of these results was observed during rTMS of corresponding left-hemisphere regions. Overall, our findings are consistent with existing evidence that the right IFG is crucial for inhibitory control. The observed double dissociation of neurodisruptive effects between the right IFG and right dPM further implies that response inhibition and execution rely on distinct neural processes despite activating a common cortical network.

  11. Structural and Mechanical Characterization of Sustainable Composites Based on Recycled and Stabilized Fly Ash

    Directory of Open Access Journals (Sweden)

    Stefano Besco


    Full Text Available This paper reports the results on the use of an innovative inert, based on stabilized fly ash from municipal solid waste incineration as a filler for polypropylene. The starting material, which contains large quantities of leachable Pb and Zn, was stabilized by means of an innovative process using rice husk ash as a waste silica source, together with other fly ashes, such as coal fly ash and flue gas desulfurization residues. The use of all waste materials to obtain a new filler makes the proposed technology extremely sustainable and competitive. The new composites, obtained by using the stabilized material as a filler for polypropylene, were characterized and their mechanical properties were also investigated. A comparison with a traditional polypropylene and calcium carbonate based compound was also done. This research activity was realized in the frame of the COSMOS-RICE project, financed by the EU Commission.

  12. Structure and mechanical characterization of DNA i-motif nanowires by molecular dynamics simulation

    CERN Document Server

    Singh, Raghvendra Pratap; Cleri, Fabrizio


    We studied the structure and mechanical properties of DNA i-motif nanowires by means of molecular dynamics computer simulations. We built up to 230 nm long nanowires, based on a repeated TC5 sequence from crystallographic data, fully relaxed and equilibrated in water. The unusual stacked C*C+ stacked structure, formed by four ssDNA strands arranged in an intercalated tetramer, is here fully characterized both statically and dynamically. By applying stretching, compression and bending deformation with the steered molecular dynamics and umbrella sampling methods, we extract the apparent Young's and bending moduli of the nanowire, as wel as estimates for the tensile strength and persistence length. According to our results, the i-motif nanowire shares similarities with structural proteins, as far as its tensile stiffness, but is closer to nucleic acids and flexible proteins, as far as its bending rigidity is concerned. Furthermore, thanks to its very thin cross section, the apparent tensile toughness is close to...

  13. Thermodynamic aspects of nanostructured Ti5Si3 formation during mechanical alloying and its characterization

    Indian Academy of Sciences (India)

    S Sabooni; F Karimzadeh; M H Abbasi


    Mechanical alloying (MA) was used to produce Ti5Si3 intermetallic compound with nanocrystalline structure from elemental powders. The structural changes and characterization of powder particles during milling were studied by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), particle size analyser (PSA) and microhardness measurements. MA resulted in gradual formation of disordered Ti5Si3 intermetallic compound with crystallite size of about 15 nm after 45 h of milling. Also a thermodynamic analysis of the process was carried out using Miedema model. The results showed that in the nominal composition of Ti5Si3 intermetallic phase (Si = 0.375), formation of an intermetallic compound has the lowest Gibbs free energy rather than solid solution or amorphous phases. So the MA product is the most stable phase in nominal composition of Ti5Si3. This intermetallic compound exhibits high microhardness value of about 1235 HV.

  14. Characterization and flocculation mechanism of a bioflocculant from hydrolyzate of rice stover. (United States)

    Guo, Junyuan; Yu, Jing; Xin, Xin; Zou, Changwu; Cheng, Qingfeng; Yang, Huaijin; Nengzi, Lichao


    This study investigated the characterization and flocculation mechanism of a bioflocculant from hydrolyzate of rice stover. Production of the bioflocculant was positively associated with cell growth and a highest value of 2.4 g L(-1) was obtained. During the kaolin suspension flocculation, charge neutralization and inter-particle bridging were proposed as the reasons for enhanced performance. Apart from this, the bioflocculant showed good performances in sludge dewatering and swine wastewater pretreatment. After conditioning by the bioflocculant, dry solids (DS) and specific resistance to filtration (SRF) of the sludge reached 18.4% and 4.8×10(12) m kg(-1), respectively, which were much better than that by conventional chemical flocculants. In the swine wastewater pretreatment, the removal efficiencies of COD, ammonium, and turbidity reached 48.3%, 43.6% and 75.8% at pH 8.0 when the bioflocculant dose was adjusted to 20 mg L(-1).

  15. Ammonia recovery from agricultural wastes by membrane distillation: fouling characterization and mechanism. (United States)

    Zarebska, A; Nieto, D Romero; Christensen, K V; Norddahl, B


    One of the main obstacles impeding implementation of membrane distillation for the recovery and concentration of ammonia from swine manure is wetting caused by fouling. Due to the different types of fouling which can occur in a membrane system, foulants characterization is a complex problem. To elucidate the fouling mechanism, deposit morphology and composition of foulants have been determined using Scanning Electron Microscopy, X-ray Energy Dispersive Spectrometry, Attenuated Total Reflectance Infrared Spectrometry, Ion chromatography and Inductively coupled plasma-optical emission spectroscopy. Based on the analysis of fouled membranes, it is concluded that membrane fouling is dominated by organic fouling in combination with deposits of inorganic elements and microorganisms. After a week of running the membrane process without cleaning, the average fouling layer thickness was estimated to 10-15 μm. The fouling layer further results in a loss of membrane hydrophobicity. This indicates that fouling could be a severe problem for membrane distillation performance.

  16. Characterization and flocculation mechanism of a bioflocculant from potato starch wastewater. (United States)

    Guo, Junyuan; Lau, Anthony K; Zhang, Yuzhe; Zhao, Jing


    This study investigated the characterization and flocculation mechanism of a bioflocculant prepared using potato starch wastewater. The optimal culture conditions of this strain were determined as 4 g K2HPO4, 2 g KH2PO4, 0.2 g MgSO4, 0.1 g NaCl, and 2.0 g urea dissolved in 1.0 L potato starch wastewater with no need of adding carbon sources or adjusting pH value. Production of this bioflocculant was positively associated with cell growth, and a highest value of 0.81 g/L was obtained. During the kaolin suspension flocculation, charge neutralization and interparticle bridging were proposed as the main reasons for enhanced performance. Further, with potato starch wastewater, chemical oxygen demand (COD) and turbidity removal rates reached 52.4 and 81.7 %, respectively, at pH 7.5 when the bioflocculant dose was adjusted to 30 mg/L.

  17. Synthesis and Characterization of Nanocrystalline Al-20 at. % Cu Powders Produced by Mechanical Alloying

    Directory of Open Access Journals (Sweden)

    Molka Ben Makhlouf


    Full Text Available Mechanical alloying is a powder processing technique used to process materials farther from equilibrium state. This technique is mainly used to process difficult-to-alloy materials in which the solid solubility is limited and to process materials where nonequilibrium phases cannot be produced at room temperature through conventional processing techniques. This work deals with the microstructural properties of the Al-20 at. % Cu alloy prepared by high-energy ball milling of elemental aluminum and copper powders. The ball milling of powders was carried out in a planetary mill in order to obtain a nanostructured Al-20 at. % Cu alloy. The obtained powders were characterized using scanning electron microscopy (SEM, differential scanning calorimetry (DSC and X-ray diffraction (XRD. The structural modifications at different stages of the ball milling are investigated with X-ray diffraction. Several microstructure parameters such as the crystallite sizes, microstrains and lattice parameters are determined.

  18. Dual Raman-Brillouin Microscope for Chemical and Mechanical Characterization and Imaging. (United States)

    Traverso, Andrew J; Thompson, Jonathan V; Steelman, Zachary A; Meng, Zhaokai; Scully, Marlan O; Yakovlev, Vladislav V


    We present a unique confocal microscope capable of measuring the Raman and Brillouin spectra simultaneously from a single spatial location. Raman and Brillouin scattering offer complementary information about a material's chemical and mechanical structure, respectively, and concurrent monitoring of both of these spectra would set a new standard for material characterization. We achieve this by applying recent innovations in Brillouin spectroscopy that reduce the necessary acquisition times to durations comparable to conventional Raman spectroscopy while attaining a high level of spectral accuracy. To demonstrate the potential of the system, we map the Raman and Brillouin spectra of a molded poly(ethylene glycol) diacrylate (PEGDA) hydrogel sample in cyclohexane to create two-dimensional images with high contrast at microscale resolutions. This powerful tool has the potential for very diverse analytical applications in basic science, industry, and medicine.

  19. Multiscale characterization of chemical–mechanical interactions between polymer fibers and cementitious matrix

    Energy Technology Data Exchange (ETDEWEB)

    Hernández-Cruz, Daniel; Hargis, Craig W.; Bae, Sungchul; Itty, Pierre A.; Meral, Cagla; Dominowski, Jolee; Radler, Michael J.; Kilcoyne, David A.; Monteiro, Paulo J. M.


    Together with a series of mechanical tests, the interactions and potential bonding between polymeric fibers and cementitious materials were studied using scanning transmission X-ray microscopy (STXM) and microtomography (lCT). Experimental results showed that these techniques have great potential to characterize the polymer fiber-hydrated cement-paste matrix interface, as well as differentiating the chemistry of the two components of a bi-polymer (hybrid) fiber the polypropylene core and the ethylene acrylic acid copolymer sheath. Similarly, chemical interactions between the hybrid fiber and the cement hydration products were observed, indicating the chemical bonding between the sheath and the hardened cement paste matrix. Microtomography allowed visualization of the performance of the samples, and the distribution and orientation of the two types of fiber in mortar. Beam flexure tests confirmed improved tensile strength of mixes containing hybrid fibers, and expansion bar tests showed similar reductions in expansion for the polypropylene and hybrid fiber mortar bars.

  20. Characterization of debond growth mechanism in adhesively bonded composites under mode II static and fatigue loadings (United States)

    Mall, S.; Kochhar, N. K.


    An experimental investigation of adhesively bonded composite joint was conducted to characterize the debond growth mechanism under mode II static and fatigue loadings. For this purpose, end-notched flexure specimens of graphite/epoxy (T300/5208) adherends bonded with EC 3445 adhesive were tested. In all specimen tested, the fatigue failure occurred in the form of cyclic debonding. The present study confirmed the result of previous studies that total strain-energy-release rate is the driving parameter for cyclic debonding. Further, the debond growth resistance under cyclic loading with full shear reversal (i.e., stress ratio, R = -1) is drastically reduced in comparison to the case when subjected to cyclic shear loading with no shear reversal (i.e., R = 0.1).

  1. Ultrasonic synthesis, characterization and formation mechanism of aggregated nanorings of EuF3

    Institute of Scientific and Technical Information of China (English)

    WU Dapeng; WANG Xinjun; BAI Zhengyu; JIANG Kai


    The aggregated nanorings of EuF3 were synthesized via ultrasonic irritation in aqueous solution. The products were characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). XRD pattern proved that the crystalline phase of the EuF3 rngs was hexagonal. The SEM and TEM images indicated that the as-prepared EuF3 nanocrys-tals had ring-like morphology and were aggregated by numerous small crystallites (about 10-15 nm in diameter); the outer diameter of the rings was in the range of 200-300 nm, while the inner diameter was in the range of 50-80 nm with a thickness of 30-40 nm. Moreover, the time-depend experiments were carried out to disclose the formation mechanism of the as-prepared ring-like nanostructures.

  2. Transactive control: a framework for operating power systems characterized by high penetration of distributed energy resources

    DEFF Research Database (Denmark)

    Hu, Junjie; Yang, Guangya; Kok, Koen


    The increasing number of distributed energy resources connected to power systems raises operational challenges for the network operator, such as introducing grid congestion and voltage deviations in the distribution network level, as well as increasing balancing needs at the whole system level......, followed by a literature review and demonstration projects that apply to transactive control. Cases are then presented to illustrate the transactive control framework. At the end, discussions and research directions are presented, for applying transactive control to operating power systems, characterized...

  3. Mechanism of Germacradien-4-ol Synthase-Controlled Water Capture (United States)


    The sesquiterpene synthase germacradiene-4-ol synthase (GdolS) from Streptomyces citricolor is one of only a few known high-fidelity terpene synthases that convert farnesyl diphosphate (FDP) into a single hydroxylated product. Crystals of unliganded GdolS-E248A diffracted to 1.50 Å and revealed a typical class 1 sesquiterpene synthase fold with the active site in an open conformation. The metal binding motifs were identified as D80DQFD and N218DVRSFAQE. Some bound water molecules were evident in the X-ray crystal structure, but none were obviously positioned to quench a putative final carbocation intermediate. Incubations in H218O generated labeled product, confirming that the alcohol functionality arises from nucleophilic capture of the final carbocation by water originating from solution. Site-directed mutagenesis of amino acid residues from both within the metal binding motifs and without identified by sequence alignment with aristolochene synthase from Aspergillus terreus generated mostly functional germacradien-4-ol synthases. Only GdolS-N218Q generated radically different products (∼50% germacrene A), but no direct evidence of the mechanism of incorporation of water into the active site was obtained. Fluorinated FDP analogues 2F-FDP and 15,15,15-F3-FDP were potent noncompetitive inhibitors of GdolS. 12,13-DiF-FDP generated 12,13-(E)-β-farnesene upon being incubated with GdolS, suggesting stepwise formation of the germacryl cation during the catalytic cycle. Incubation of GdolS with [1-2H2]FDP and (R)-[1-2H]FDP demonstrated that following germacryl cation formation a [1,3]-hydride shift generates the final carbocation prior to nucleophilic capture. The stereochemistry of this shift is not defined, and the deuteron in the final product was scrambled. Because no clear candidate residue for binding of a nucleophilic water molecule in the active site and no significant perturbation of product distribution from the replacement of active site residues were

  4. Characterization of microstructure and mechanical behavior of sputter deposited Ti-containing amorphous carbon coatings.

    Energy Technology Data Exchange (ETDEWEB)

    Feng, B.; Cao, D. M.; Meng, W. J.; Xu, J.; Tittsworth, R. C.; Rehn, L. E.; Baldo, P. M.; Doll, G. L.; Materials Science Division; Louisiana State Univ.; The Timken Company


    We report on the characterization of microstructure and mechanical properties of sputter deposited Ti-containing amorphous carbon (Ti-aC) coatings as a function of Ti composition. Ti-aC coatings have been deposited by unbalanced magnetron sputter deposition, in an industrial-scale four-target coating deposition system. The composition and microstructure of the Ti-aC coatings have been characterized in detail by combining the techniques of Rutherford backscattering spectrometry (RBS) and hydrogen elastic recoil detection (ERD), transmission electron microscopy (TEM), X-ray absorption near edge structure (XANES) spectroscopy and extended X-ray absorption fine structure (EXAFS) spectroscopy. At Ti compositions <4at.%, Ti atoms dissolve in an amorphous carbon (a-C) matrix. The dissolution limit of Ti atoms in an a-C matrix is determined to be between 4 and 8 at.%. At Ti compositions >8 at.%, XANES and EXAFS data indicate that the average Ti atomic bonding environment in Ti-aC coatings resembles that in cubic B1-TiC, consistent with TEM observation of precipitation of TiC nanocrystallites in the a-C matrix. Beyond the Ti dissolution limit, the Ti-aC coatings are nanocomposites with nanocrystalline TiC clusters embedded in an a-C matrix. A large scale, quasi one-dimensional composition modulation in the Ti-aC coatings was observed due to the particular coating deposition geometry. Elastic stiffness and hardness of the Ti-aC coatings were measured by instrumented nanoindentation and found to vary systematically as a function of Ti composition. Unlubricated friction coefficient of Ti-aC coatings against WC-Co balls was found to increase as the Ti composition increases. As Ti composition increases, the overall mechanical behavior of the Ti-aC coatings becomes more TiC-like.

  5. Microstructural characterization and some mechanical properties of gas-borided Inconel 600-alloy

    Energy Technology Data Exchange (ETDEWEB)

    Makuch, N.; Kulka, M., E-mail:


    Graphical abstract: - Highlights: • Two-stage gas boriding was proposed to produce the boride layer on Inconel 600-alloy. • The microstructure of diffusion zone consisted of compact borides zone and borides at grain boundaries. • The identification of nickel and chromium borides required the use of a special etching solution. • The diffusion along grain boundaries was indicated as a predominant mechanism of boron diffusion. • The increased hardness and improved wear resistance of gas-borided layer were obtained. - Abstract: The excellent resistance of Ni-based alloys to corrosion and oxidation is well-known. Boriding can be applied to these alloys in order to obtain suitable wear protection. In this paper, two-stage gas boronizing in N{sub 2}–H{sub 2}–BCl{sub 3} atmosphere is proposed for the producing the boride layer on Inconel{sup ®}600-alloy. This process consists in two stages alternately repeated: saturation by boron and diffusion annealing. Such a gas boriding is applied in order to accelerate the saturation by boron and its diffusion. It turns out to be more effective because of eliminating the excess of boron, diffusing into the substrate, during the second stage. Microstructure and some mechanical properties of the produced layer are presented. Microstructural characterization is studied with using an optical microscope, scanning electron microscope, energy-dispersive x-ray microanalysis and x-ray diffraction. The diffusion zone consists of the mixture of nickel and chromium borides, occurring in the compact boride zone and in the area located beneath, at grain boundaries. The improved hardness and wear resistance characterize the layer. The formed boride layer is significantly thicker than those-obtained by the pack-boronizing or paste process at comparable temperature and time. Simultaneously, the measured depth of layer is slightly smaller than that-reported for electrolytic boriding.

  6. Optical tests of a space mechanism under an adverse environment: GAIA secondary mirror mechanism under vaccum and thermal controlled conditions (United States)

    Ramos Zapata, Gonzalo; Sánchez Rodríguez, Antonio; Belenguer Dávila, Tomás; Urgoiti, Eduardo; Ramírez Quintana, Argiñe


    In this work, the optical evaluation of a mechanism for space applications under vacuum and temperature controlled conditions at the facilities of the Space Instrumentation Laboratory (LINES) of the Aerospace Technical Nacional Institute of Spain (INTA) is reported. The mechanism was developed by the Spanish company SENER to fulfill the high performance requirements from ESA technology preparatory program for GAIA Astrometric Mission; in particular, a five degrees of freedom (dof), three translations and two rotations positioning mechanism for the secondary mirror of the GAIA instrument. Both interferometric tests and autocollimator measurements have been combined in order to extract the information about the accuracy of the mechanism movements as well as their repeatability under adverse environmental conditions: vacuum and thermal controlled conditions, up to a 10 -6mbar and 100K. The scope of this paper will cover the measurements concept selection, the presentation of verification activities, the results of such dedicated optical measurements, the correlation with the mechanical models and a brief description of the design process followed to meet the test requirements.

  7. Synthesis, structural characterization and formation mechanism of ferroelectric bismuth vanadate nanotubes. (United States)

    Singh, Satyendra; Kumari, Neelam; Varma, K B R; Krupanidhi, S B


    We report the synthesis and structural characterization of ferroelectric bismuth vanadate (Bi2VO5.5) (BVO) nanotubes within the nanoporous anodic aluminum oxide (AAO) templates via sol-gel method. The as-prepared BVO nanotubes were characterized by X-ray powder diffraction (XRD), Scanning Electron Microscope (SEM), High-Resolution Transmission Electron Microscope (HRTEM) and the stoichiometry of the nanotubes was established by energy-dispersive X-ray spectroscopy (EDX). Postannealed (675 degrees C for 1 h), BVO nanotubes were a polycrystalline and the XRD studies confirmed the crystal structure to be orthorhombic. The uniformity in diameter and length of the nanotubes as reveled by the TEM and SEM suggested that these were influenced to a guest extent by the thickness and pore diameter of the nanoporous AAO template. EDX analysis demonstrated the formation of stoichiometric Bi2VO5.5 phase. HRTEM confirmed that the obtained BVO nanotubes were made up of nanoparticles of 5-9 nm range. The possible formation mechanism of nanotubes was elucidated.

  8. Microstructural characterization and some mechanical properties of gas-borided Inconel 600-alloy (United States)

    Makuch, N.; Kulka, M.


    The excellent resistance of Ni-based alloys to corrosion and oxidation is well-known. Boriding can be applied to these alloys in order to obtain suitable wear protection. In this paper, two-stage gas boronizing in N2-H2-BCl3 atmosphere is proposed for the producing the boride layer on Inconel®600-alloy. This process consists in two stages alternately repeated: saturation by boron and diffusion annealing. Such a gas boriding is applied in order to accelerate the saturation by boron and its diffusion. It turns out to be more effective because of eliminating the excess of boron, diffusing into the substrate, during the second stage. Microstructure and some mechanical properties of the produced layer are presented. Microstructural characterization is studied with using an optical microscope, scanning electron microscope, energy-dispersive x-ray microanalysis and x-ray diffraction. The diffusion zone consists of the mixture of nickel and chromium borides, occurring in the compact boride zone and in the area located beneath, at grain boundaries. The improved hardness and wear resistance characterize the layer. The formed boride layer is significantly thicker than those-obtained by the pack-boronizing or paste process at comparable temperature and time. Simultaneously, the measured depth of layer is slightly smaller than that-reported for electrolytic boriding.

  9. The use of fuzzy control system methods for characterizing expert judgment uncertainty distributions

    Energy Technology Data Exchange (ETDEWEB)

    Smith, R.E.; Booker, J.M.; Bement, T.R.; Parkinson, W.J.; Meyer, M.A. [Los Alamos National Lab., NM (United States); Jamshidi, M. [Univ. of New Mexico, Albuquerque, NM (United States)


    Fuzzy logic methods permit experts to assess parameters affecting performance of components/systems in natural language terms more familiar to them (e.g., high, good, etc.). Recognizing that there is a cost associated with obtaining more precise information, the authors particular interest is in cases where the relationship between the condition of the system and its performance is not well understood, especially for some sets of possible operating conditions, and where developing a better understanding is very difficult and/or expensive. The methods allow the experts to make use of the level of precision with which they understand the underlying process. The authors consider and compare various methods of formulating the process just described, with an application in reliability analysis where expert information forms a significant (if not sole) source of data for reliability analysis. The flow of information through the fuzzy-control-systems based analysis is studied using a simple, hypothetical problem which mimics the structure used to elicit expert information in Parse. They also characterize the effect of using progressively more refined information and examine the use of fuzzy-based methods as data pooling/fusion mechanisms.

  10. Characterization and regulation of mechanical loading-induced compensatory muscle hypertrophy. (United States)

    Adams, Gregory R; Bamman, Marcas M


    In mammalian systems, skeletal muscle exists in a dynamic state that monitors and regulates the physiological investment in muscle size to meet the current level of functional demand. This review attempts to consolidate current knowledge concerning development of the compensatory hypertrophy that occurs in response to a sustained increase in the mechanical loading of skeletal muscle. Topics covered include: defining and measuring compensatory hypertrophy, experimental models, loading stimulus parameters, acute responses to increased loading, hyperplasia, myofiber-type adaptations, the involvement of satellite cells, mRNA translational control, mechanotransduction, and endocrinology. The authors conclude with their impressions of current knowledge gaps in the field that are ripe for future study.

  11. Characterization of accessibility for affine connection control systems at some points with nonzero velocity

    CERN Document Server

    Barbero-Liñán, María


    Affine connection control systems are mechanical control systems that model a wide range of real systems such as robotic legs, hovercrafts, planar rigid bodies, rolling pennies, snakeboards and so on. In 1997 the accessibility and a particular notion of controllability was intrinsically described by A. D. Lewis and R. Murray at points of zero velocity. Here, we present a novel generalization of the description of accessibility algebra for those systems at some points with nonzero velocity as long as the affine connection restricts to the distribution given by the symmetric closure. The results are used to describe the accessibility algebra of different mechanical control systems.

  12. Interleukin 4: signalling mechanisms and control of T cell differentiation. (United States)

    Paul, W E


    Interleukin 4 (IL-4) is a pleiotropic type I cytokine that controls both growth and differentiation among haemopoietic and non-haemopoietic cells. Its receptor is a heterodimer. One chain, the IL-4R alpha chain, binds IL-4 with high affinity and determines the nature of the biochemical signals that are induced. The second chain, gamma c, is required for the induction of such signals. IL-4-mediated growth depends upon activation events that involve phosphorylation of Y497 of IL-4R alpha, leading to the binding and phosphorylation of 4PS/IRS-2 in haemopoietic cells and of IRS-1 in non-haemopoietic cells. By contrast, IL-4-mediated differentiation events depend upon more distal regions of the IL-4R alpha chain that include a series of STAT-6 binding sites. The distinctive roles of these receptor domains was verified by receptor-reconstruction experiments. The 'growth' and 'differentiation' domains of the IL-4R alpha chain, independently expressed as chimeric structures with a truncated version of the IL-2R beta chain, were shown to convey their functions to the hybrid receptor. The critical role of STAT-6 in IL-4-mediated gene activation and differentiation was made clear by the finding that lymphocytes from STAT-6 knockout mice are strikingly deficient in these functions but have retained the capacity to grow, at least partially, in response to IL-4. IL-4 plays a central role in determining the phenotype of naive CD4+ T cells. In the presence of IL-4, newly primed naive T cells develop into IL-4 producers while in its absence they preferentially become gamma-interferon (IFN-gamma) producers. Recently, a specialized subpopulation of T cells, CD4+/NK1.1+ cells, has been shown to produce large amounts of IL-4 upon stimulation. Two examples of mice with deficiencies in these cells are described--beta 2-microglobulin knockout mice and SJL mice. Both show defects in the development of IL-4-producing cells and in the increase in serum IgE in response to stimulation with the

  13. Modeling and Control of Hybrid Machine Systems——a Five-bar Mechanism Case

    Institute of Scientific and Technical Information of China (English)

    Hongnian Yu


    A hybrid machine (HM) as a typical mechatronic device, is a useful tool to generate smooth motion, and combines the motions of a large constant speed motor with a small servo motor by means of a mechnical linkage mechanism, in order to provide a powerful programmable drive system. To achieve design objectives, a control system is required. To design a better control system and analyze the performance of an HM, a dynamic model is necessary. This paper first develops a dynamic model of an HM with a five-bar mechanism using a Lagrangian formulation. Then, several important properties which are very useful in system analysis, and control system design, are presented. Based on the developed dynamic model,two control approaches, computed torque, and combined computed torque and slide mode control, are adopted to control the HM system. Simulation results demonstrate the control performance and limitations of each control approach.

  14. Intelligent Integrated Control of Underactuated Mechanical Systems with Second-order Nonholonomic Constraints

    Institute of Scientific and Technical Information of China (English)

    Lai Xuzhi(赖旭芝); Wu Min; Cai Zixing; She Jinhua


    This paper describes an intelligent integrated control of an acrobot, which is an underactuated mechanical system with second-order nonholonomic constraints. The control combines a model-free fuzzy control, a fuzzy sliding-mode control and a model-based fuzzy control. The model-free fuzzy controller designed for the upswing ensures that the energy of the acrobot increases with each swing. Then the fuzzy sliding-mode controller is employed to control the movement that the acrobot enters the balance area from the swing-up area. The model-based fuzzy controller, which is based on a Takagi-Sugeno fuzzy model, is used to balance the acrobot. The stability of the fuzzy control system for balance control is guaranteed by a common symmetric positive matrix, which satisfies linear matrix inequalities.

  15. A new formal model for privilege control with supporting POSIX capability mechanism

    Institute of Scientific and Technical Information of China (English)

    JI Qingguang; QING Sihan; HE Yeping


    In order to enforce the least privilege principle in the operating system, it is necessary for the process privilege to be effectively controlled; but this is very difficult because a process always changes as time changes. In this paper, based on the analysis on how the process privilege is generated and how it works, a hierarchy implementing the least privilege principle with three layers, i.e. administration layer, functionality control layer and performance layer, is posed. It is clearly demonstrated that to bound privilege's working scope is a critical part for controlling privilege, but this is only mentioned implicitly while not supported in POSIX capability mechanism. Based on analysis of existing control mechanism for privilege, not only an improved capability inheritance formula but also a new complete formal model for controlling process based on integrating RBAC, DTE, and POSIX capability mechanism is introduced. The new invariants in the model show that this novel privilege control mechanism is different from RBAC's, DTE's, and POSIX's, and it generalizes subdomain control mechanism and makes this mechanism dynamic.

  16. Two-Photon Polymerization Metrology: Characterization Methods of Mechanisms and Microstructures

    Directory of Open Access Journals (Sweden)

    Christopher N. LaFratta


    Full Text Available The ability to create complex three-dimensional microstructures has reached an unprecedented level of sophistication in the last 15 years. For the most part, this is the result of a steady development of the additive manufacturing technique named two-photon polymerization (TPP. In a short amount of time, TPP has gone from being a microfabrication novelty employed largely by laser specialists to a useful tool in the hands of scientists and engineers working in a wide range of research fields including microfluidics. When used in combination with traditional microfabrication processes, TPP can be employed to add unique three-dimensional components to planar platforms, thus enabling the realization of lab-on-a-chip solutions otherwise impossible to create. To take full advantage of TPP, an in-depth understanding is required of the materials photochemistry and the fabricated microstructures’ mechanical and chemical properties. Thus, we review methods developed so far to investigate the underling mechanism involved during TPP and analytical methods employed to characterize TPP microstructures. Furthermore, we will discuss potential opportunities for using optofluidics and lab-on-a-chip systems for TPP metrology.

  17. A new experimental setup to characterize the dynamic mechanical behaviour of ballistic yarns (United States)

    Chevalier, C.; Kerisit, C.; Boussu, F.; Coutellier, D.; Faderl, N.; Klavzar, A.


    Fabrics have been widely used as part of ballistic protections since the 1970s and the development of new ballistic solutions made from fabrics need numerical simulations, in order to predict the performance of the ballistic protection. The performances and the induced mechanisms in ballistic fabrics during an impact depend on the weaving parameters and also on the inner parameters of the yarns used inside these structures. Thus, knowing the dynamic behaviour of yarn is essential to determine the ballistic behaviour of fabrics during an impact. Two major experimental devices exist and are used to test ballistic yarns in a dynamic uniaxial tension. The first one corresponds to the Split Hopkinson Tensile Bars device, which is commonly used to characterize the mechanical properties of materials in uniaxial tension and under high loading. The second one is the transversal impact device. The real conditions of ballistic impact can be realized with this device. Then, this paper deals with a new experimental setup developed in our laboratory and called the ‘tensile impact test for yarn’ (TITY) device. With this device, specific absorbed energy measurements of para-aramid yarns (336 Tex, Twaron™, 1000 filaments) have been carried out and revealed that static and dynamic properties of para-aramid are different.

  18. Structure and Mechanical Characterization of DNA i-Motif Nanowires by Molecular Dynamics Simulation (United States)

    Singh, Raghvendra Pratap; Blossey, Ralf; Cleri, Fabrizio


    We studied the structure and mechanical properties of DNA i-motif nanowires by means of molecular dynamics computer simulations. We built up to 230 nm-long nanowires, based on a repeated TC5 sequence from crystallographic data, fully relaxed and equilibrated in water. The unusual C⋅C+ stacked structure, formed by four ssDNA strands arranged in an intercalated tetramer, is here fully characterized both statically and dynamically. By applying stretching, compression, and bending deformations with the steered molecular dynamics and umbrella sampling methods, we extract the apparent Young’s and bending moduli of the nanowire, as well as estimates for the tensile strength and persistence length. According to our results, the i-motif nanowire shares similarities with structural proteins, as far as its tensile stiffness, but is closer to nucleic acids and flexible proteins, as far as its bending rigidity is concerned. Furthermore, thanks to its very thin cross section, the apparent tensile toughness is close to that of a metal. Besides their yet to be clarified biological significance, i-motif nanowires may qualify as interesting candidates for nanotechnology templates, due to such outstanding mechanical properties. PMID:24359754

  19. Mechanical properties characterization of composite sandwich materials intended for space antenna applications (United States)

    Bowles, Kenneth J.; Vannucci, Raymond D.


    The composite materials proposed for use in the Advanced Communications Technology Satellite (ACTS) Program contains a new, high modulus graphite fiber as the reinforcement. A study was conducted to measure certain mechanical properties of the new fiber-reinforced material as well as of a composite-faced aluminum honeycomb sandwich structure. Properties were measured at -157, 22, and 121 C. Complete characterization of this material was not intended. Longitudinal tensile, picture-frame shear, short-beam shear, and flexural tests were performed on specimens of the composite face-sheet materials. Unidirectional, cross-plied, and quasi-isotropic fiber composite ply layup designs were fabricated and tested. These designs had been studied by using NASA's Integrated Composite Analyzer (ICAN) computer program. Flexural tests were conducted on (+/- 60/0 deg) sub s composite-faced sandwich structure material. Resistance strain gages were used to measure strains in the tensile, picture-frame, and sandwich flexural tests. The sandwich flexural strength was limited by the core strength at -157 and 22 C. The adhesive bond strength was the limiting factor at 121 C. Adhesive mechanical properties are reflected in sandwich structure flexural properties when the span-to-depth ratio is great enough to allow a significant shear effect on the load-deflection behavior of the sandwich beam. Most measured properties agreed satisfactorily with the properties predicted by ICAN.

  20. Hybrid Micro-Electro-Mechanical Systems for Highly Reliable and Selective Characterization of Tank Waste

    Energy Technology Data Exchange (ETDEWEB)

    Panos G. Datskos; Michael J. Sepaniak; Nickolay Lavrik; Pampa Dutta; Mustafa Culha


    The main objective of this research program is to develop robust and reliable micro-electro-mechanical sensing systems, based on microcantilevers (MCs), that can operate in liquid environments with high levels of sensitivity and selectivity. The chemical responses of MCs result from analyte-induced differential stress at the cantilever surfaces. We aim to employ various surface nanostructuring strategies that enhance these stresses and hence the degree of static bending of the cantilevers. Receptor phases as self assembled monolayers (SAMs) and thin films are being synthesized and tested to provide selectivity. Selectivity is chemically enhanced by using different phases on individual MCs in arrays and by adding a spectroscopic component, surface enhanced Raman spectrometry (SERS), in hybrid approaches to sensing. Significant progress was made in tasks that were listed in the work plan for DOE EMSP project ''Hybrid Micro-Electro-Mechanical Systems for Highly Reliable and Selective Characterization of Tank Waste''. Several project areas are listed below and discussed and referenced to our literature on the topics.

  1. Mechanical Characterization of an Additively Manufactured Inconel 718 Theta-Shaped Specimen (United States)

    Cakmak, Ercan; Watkins, Thomas R.; Bunn, Jeffrey R.; Cooper, Ryan C.; Cornwell, Paris A.; Wang, Yanli; Sochalski-Kolbus, Lindsay M.; Dehoff, Ryan R.; Babu, Sudarsanam S.


    Two sets of "theta"-shaped specimens were additively manufactured with Inconel 718 powders using an electron beam melting technique with two distinct scan strategies. Light optical microscopy, mechanical testing coupled with a digital image correlation (DIC) technique, finite element modeling, and neutron diffraction with in situ loading characterizations were conducted. The cross-members of the specimens were the focus. Light optical micrographs revealed that different microstructures were formed with different scan strategies. Ex situ mechanical testing revealed each build to be stable under load until ductility was observed on the cross-members before failure. The elastic moduli were determined by forming a correlation between the elastic tensile stresses determined from FEM, and the elastic strains obtained from DIC. The lattice strains were mapped with neutron diffraction during in situ elastic loading; and a good correlation between the average axial lattice strains on the cross-member and those determined from the DIC analysis was found. The spatially resolved stresses in the elastic deformation regime are derived from the lattice strains and increased with applied load, showing a consistent distribution along the cross-member.

  2. Structural Characterization and Ordering Transformation of Mechanically Alloyed Nanocrystalline Fe-28Al Powder

    Directory of Open Access Journals (Sweden)

    Lima Amiri Talischi


    Full Text Available The synthesis of nanocrystalline Fe3Al powder by mechanical alloying as well as the structural ordering of the synthesized Fe3Al particles during the subsequent thermal analysis were investigated. Mechanical alloying was performed up to 100 hours using a planetary ball mill apparatus with rotational speed of 300 rpm under argon atmosphere at ambient temperature. The synthesized powders were characterized using X-ray diffraction, SEM observations and differential scanning calorimetry (DSC. The results show that the A2-type Fe3Al with disordered bcc structure is only formed after 70 hours milling. The corresponding lattice strain, mean crystallite and particle sizes for the 70 hours milled Fe3Al powder were determined as 2.5%, 10 and 500 nm, respectively. The subsequent heating during DSC causes a DO3-type Fe3Al ordering in 70 and 100 hours milled powders, however in 40 hours milled powder it only assists for the formation of disordered solid solution. Longer milling time induces a large amount of lattice strain in Fe3Al powder particles and consequently facilitates the atomic diffusion thus decreases the activation energy of ordering. The activation energy for ordering transformation of 100 hours Fe3Al milled powder was calculated as 152.1 kJ/mole which is about 4 kJ/mole lower than that for 70 hours milled powder.

  3. Characterization of Mechanical Properties: Low-Density Polyethylene Nanocomposite Using Nanoalumina Particle as Filler

    Directory of Open Access Journals (Sweden)

    Ching Yern Chee


    Full Text Available Nanocomposites based on low-density polyethylene (LDPE, containing 0.5, 1, 2, 3, and 5 wt% of nanoalumina, were prepared by melt-mixing at 125°C and hot melt-pressing to thin polymer film at 125°C. To enhance the interfacial interaction between alumina and LDPE, alumina surface was treated with silane which acts as coupling agent. The effects of alumina additions to the structure and morphology of LDPE matrix were characterized using Fourier transform infrared spectroscopy (FTIR and scanning electron microscopy (SEM, respectively. The mechanical behaviour of nanoalumina-reinforced LDPE composite was studied using tensile tests, flexural tests, and impact tests. The interfacial adhesion between nano alumina particle and LDPE matrix was investigated. The result showed that the reinforcement performance of nano alumina to LDPE matrix was attributed to the interfacial adhesion between nanoparticle and polymer matrix. The addition of 1 wt% nano alumina has successfully enhanced the mechanical properties of LDPE material.

  4. Electrical, Mechanical, and Morphological Characterization of Carbon Nanotube filled Polymeric Nanofibers (United States)

    Gorga, Russell; Clarke, Laura; McCullen, Seth; Ojha, Satyajeet; Roberts, Wesley


    This work focuses on the inclusion of conductive nanotubes into polymeric matrices with the end goal of creating conductive nanocomposites. This investigation has been carried out by uniform dispersion of multi-walled carbon nanotubes in aqueous solutions of polyvinyl alcohol (PVA) and polyethylene oxide (PEO), which are inherently nonconductive polymers. To fabricate these structures we are using the electrospinning process encompassing an array of collection methods including parallel bars and a static plate. Carbon nanotubes are known to have excellent electrical conductivity and mechanical properties. This investigation shows that the inclusion of carbon nanotubes increases the electronic conduction in these polymers and enhances the mechanical properties of the composites. Dispersion of these nanotubes is the key factor in this process; gum Arabic and surfactants have been utilized for the dispersion of these nanotubes. Conductivity measurements have been carried out by two point probe method and by performing sensitive current and conductance measurements with a femtoammeter. Further morphological characterization has been performed using scanning electron microscopy (SEM) and transmission electron microscopy (TEM).^1 Department of Textile Engineering, Chemistry, and Science ^2 Department of Physics

  5. Characterization of the Mechanical and Electromechanical Properties of Carbon Nanotube-Latex Thin Films (United States)

    Wang, Long

    The safe, reliable, and efficient operation of structural systems can be undermined by various damage modes. To identify and respond to structural damage in a timely fashion, technologies for structural health monitoring (SHM) have been extensively studied and widely applied in practice. In this context, strain sensors play a crucial role in evaluating structural performance, as they can provide insights about internal stresses within structural components. As compared to conventional rigid and locally implemented strain sensors, piezoresistive nanostructured materials provide considerable opportunities for developing flexible, light-weight, and densely distributed sensors or "sensing skins." Although many types of nanomaterial-based strain sensors have been fabricated, most of them rely on complicated and expensive manufacturing procedures, which hinder their large-scale applications. To address the aforementioned limitations, this thesis proposes the development, optimization, and characterization of a type of spray-fabricated carbon nanotube (CNT)-based thin film strain sensor. By using spray coating or airbrushing, thin films can be coated and readily applied onto large structural surfaces. It was found that the mechanical and electrical properties of the nanocomposite films could be optimized by modifying CNT concentrations and conducting post-fabrication annealing. Overall, the CNT nanocomposite films possess favorable mechanical properties as well as stable and reversible electromechanical properties, rendering them promising candidates as strain sensors suitable for SHM applications.

  6. Morphological and mechanical characterization of composite calcite/SWCNT-COOH single crystals. (United States)

    Calvaresi, Matteo; Falini, Giuseppe; Pasquini, Luca; Reggi, Michela; Fermani, Simona; Gazzadi, Gian Carlo; Frabboni, Stefano; Zerbetto, Francesco


    A growing number of classes of organic (macro)molecular materials have been trapped into inorganic crystalline hosts, such as calcite single crystals, without significantly disrupting their crystalline lattices. Inclusion of an organic phase plays a key role in enhancing the mechanical properties of the crystals, which are believed to share structural features with biogenic minerals. Here we report the synthesis and mechanical characterization of composite calcite/SWCNT-COOH single crystals. Once entrapped into the crystals SWCNT-COOH appeared both as aggregates of entangled bundles and nanoropes. Their observation was possible only after crystal etching, fracture or FIB (focused ion beam) cross-sectioning. SWCNT-COOHs occupied a small volume fraction and were randomly distributed into the host crystal. They did not strongly affect the crystal morphology. However, although the Young's modulus of composite calcite/SWCNT-COOH single crystals was similar to that of pure calcite their hardness increased by about 20%. Thus, SWCNT-COOHs provide an obstacle against the dislocation-mediated propagation of plastic deformation in the crystalline slip systems, in analogy with the well-known hardness increase in fiber-reinforced composites.

  7. Characterization and flocculation mechanism of an alkali-activated polysaccharide flocculant from Arthrobacter sp. B4. (United States)

    Li, Yumei; Li, Qiang; Hao, Dakui; Hu, Zhiheng; Song, Dongxue; Yang, Min


    The characterization and flocculation mechanism of a bioflocculant produced by Arthrobacter sp. B4 were investigated. The bioflocculant's active ingredient was a polysaccharide (B4-PS) that consisted of three main fractions corresponding to the molecular weights of approximately 3.97×10(4)Da, 6.84×10(3)Da and 5.9×10(6)Da, respectively. These fractions were composed of galactose, glucose, mannose and glucuronic acid. Flocculation experiments showed that B4-PS could spontaneously flocculate in the presence of Ca(2+) ions at a high pH (>12.0), followed by the pH reduction to ∼6.0. The self-flocculation of B4-PS may be mediated by ionization and charge neutralization mechanism. Furthermore, B4-PS exhibited excellent capabilities for pollutant removal and pH reduction in alkaline wastewater. These data suggest B4-PS may be a promising tool for use in industrial alkaline wastewater pretreatment.

  8. Assessment of rock wool as support material for on-site sanitation: hydrodynamic and mechanical characterization. (United States)

    Wanko, Adrien; Laurent, Julien; Bois, Paul; Mosé, Robert; Wagner-Kocher, Christiane; Bahlouli, Nadia; Tiffay, Serge; Braun, Bouke; Provo kluit, Pieter-Willem


    This study proposes mechanical and hydrodynamic characterization of rock wool used as support material in compact filter. A double-pronged approach, based on experimental simulation of various physical states of this material was done. First of all a scanning electron microscopy observation allows to highlight the fibrous network structure, the fibres sizing distribution and the atomic absorption spectrum. The material was essentially lacunar with 97 ± 2% of void space. Static compression tests on variably saturated rock wool samples provide the fact that the strain/stress behaviours depend on both the sample conditioning and the saturation level. Results showed that water exerts plastifying effect on mechanical behaviour of rock wool. The load-displacement curves and drainage evolution under different water saturation levels allowed exhibiting hydraulic retention capacities under stress. Finally, several tracer experiments on rock wool column considering continuous and batch feeding flow regime allowed: (i) to determine the flow model for each test case and the implications for water dynamic in rock wool medium, (ii) to assess the rock wool double porosity and discuss its advantages for wastewater treatment, (iii) to analyse the benefits effect for water treatment when the high level of rock wool hydric retention was associated with the plug-flow effect, and (iv) to discuss the practical contributions for compact filter conception and management.

  9. Fabrication and mechanical characterization of a polyvinyl alcohol sponge for tissue engineering applications. (United States)

    Karimi, A; Navidbakhsh, M; Faghihi, S


    Polyvinyl alcohol (PVA) sponges are widely used for clinical applications, including ophthalmic surgical treatments, wound healing and tissue engineering. There is, however, a lack of sufficient data on the mechanical properties of PVA sponges. In this study, a biomechanical method is used to characterize the elastic modulus, maximum stress and strain as well as the swelling ratio of a fabricated PVA sponge (P-sponge) and it is compared with two commercially available PVA sponges (CENEFOM and EYETEC). The results indicate that the elastic modulus of the P-sponge is 5.32% and 13.45% lower than that of the CENEFOM and EYETEC sponges, while it bears 4.11% more and 10.37% less stress compared to the CENEFOM and EYETEC sponges, respectively. The P-sponge shows a maximum strain of 32% more than the EYETEC sponge as well as a 26.78% higher swelling ratio, which is a significantly higher absorbency compared to the CENEFOM. It is believed that the results of this study would help for a better understanding of the extension, rupture and swelling mechanism of PVA sponges, which could lead to crucial improvement in the design and application of PVA-based materials in ophthalmic and plastic surgeries as well as wound healing and tissue engineering.

  10. Mechanical and tribological characterization of TiB2 thin films. (United States)

    Silva, F J G; Casais, R C B; Martinho, R P; Baptista, A P M


    Titanium Diboride (TiB2) presents high mechanical and physical properties. Some wear studies were also carried out in order to evaluate its tribological properties. One of the most popular wear tests for thin films is the ball-cratering configuration. This work was focused on the study of the tribological properties of TiB2 thin films using micro-abrasion tests and following the BS EN 1071-6: 2007 standard. Due to high hardness usually patented by these films, diamond was selected as abrasive on micro-abrasion tests. Micro-abrasion wear tests were performed under five different durations, using the same normal load, speed rotation and ball. Films were deposited by unbalanced magnetron sputtering Physical Vapour Deposition (PVD) technique using TiB2 targets. TiB2 films were characterized using different methods as Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDS), Atomic Force Microscopy (AFM), X-ray Diffraction (XRD), Electron Probe Micro-Analyser (EPMA), Ultra Micro Hardness and Scratch-test Analysis, allowing to confirm that TiB2 presents adequate mechanical and physical properties. Ratio between hardness (coating and abrasive particles), wear resistance and wear coefficient were studied, showing that TiB2 films shows excellent properties for tribological applications.

  11. Characterizing depth-dependent refractive index of articular cartilage subjected to mechanical wear or enzymic degeneration (United States)

    Wang, Kuyu; Wu, Jianping; Day, Robert; Kirk, Thomas Brett; Hu, Xiaozhi


    Utilizing a laser scanning confocal microscope system, the refractive indices of articular cartilage (AC) with mechanical or biochemical degenerations were characterized to investigate whether potential correlations exist between refractive index (RI) and cartilage degeneration. The cartilage samples collected from the medial femoral condyles of kangaroo knees were mechanically degenerated under different loading patterns or digested in trypsin solution with different concentrations. The sequences of RI were then measured from cartilage surface to deep region and the fluctuations of RI were quantified considering combined effects of fluctuating frequency and amplitude. The compositional and microstructural alterations of cartilage samples were assessed with histological methods. Along with the loss of proteoglycans, the average RI of cartilage increased and the local fluctuation of RI became stronger. Short-term high-speed test induced little influence to both the depth fluctuation and overall level of RI. Long-term low-speed test increased the fluctuation of RI but the average RI was barely changed. The results substantially demonstrate that RI of AC varies with both compositional and structural alterations and is potentially an indicator for the degeneration of AC.

  12. A control model for hysteresis based on microscopic polarization mechanisms in piezoelectric actuator

    Institute of Scientific and Technical Information of China (English)

    RU Chang-hai; SUN Li-ning; RONG Wei-bin


    Aiming at the limitation of control accuracy caused by hysteresis and creep for a piezoelectric actuator, the hysteresis phenomenon is explained based on the microscopic polarization mechanism and domain wall theory. Then a control model based on polarization is established, which can reduce the hysteresis and creep remarkablely. The experimental results show that the polarization control method is with more linearity and less hysteresis compared with the voltage control method.

  13. Mechanisms of Morphology Development and Control in Polymer- Polymer Blends (United States)

    Macosko, Christopher W.


    Polymer-polymer blends continue to be the most important method for achieving optimization of properties in plastics products. Over 30 percent of all plastics are blends. While miscible blends generally give average properties between the components, immiscible blends offer synergistic possibilities such as high modulus with high toughness; high flow with high impact strength or diffusion barriers with good mechanical properties and low cost. The key to performance of these immiscible blends is their morphology. There are several important types of morphology which can lead to valuable property improvement: emulsion - small polymer spheres well dispersed in a polymer matrix. double emulsion - spheres inside spheres which are dispersed in another matrix. microlayer - thin, parallel layers of one polymer in a matrix. cocontinuous - two (or more) continuous, interpenetrating polymer phases. To be economical it is desirable to create these morphologies via melt mixing of powder or pellets in conventional compounding equipment. The melting stage during compounding is very important for morphology development. This presentation will demonstrate the role of melting or softening of each phase as well as their viscosity, elasticity and interfacial tension in morphology development. Interfacial modification with premade block copolymers or reactively formed copolymers can greatly alter morphology formation and stability. Experimental results will be presented which quantify the role of these additives. References to recent work in this area by our group are listed below: DeBrule, M. B., L. Levitt and C.W. Macosko, "The Rheology and Morphology of Layered Polymer Melts in Shear," Soc. Plastics Eng. Tech Papers (ANTEC), 84-89 (1996). Guegan, P., C. W. Macosko, T. Ishizone, A. Hirao and S. Nakahama, "Kinetics of Chain Coupling at Melt Interfaces, Macromol. 27, 4993-4997 (1994). Lee, M. S., T.P. Lodge, and C. W. Macosko, "Can Random Copolymers Serve as Effective Polymeric

  14. Error Analysis and Compensation Method on the Mechanical Structure of the Hydraulic Control System

    Directory of Open Access Journals (Sweden)

    Luo Yanyan


    Full Text Available Mechanical deformation of mechanical transmission part in hydraulic control system directly affects the loading accuracy of the system. For improving the mechanical properties of the system, The force analysis and motion analysis of mechanism are simulated based on the four-bar linkage structure (FLS, and kinematics simulation is designed by using Matlab program, then came to a system error bar graph. The system error was calculated accurately according to the results of the structural mechanics simulation made by Solidworks motion module. The structure of the system will be modified when systematic errors exceed the required limit values until it reach the required value.

  15. Mg micro/nanoscale materials with sphere-like morphologies:Size-controlled synthesis and characterization

    Institute of Scientific and Technical Information of China (English)


    Mg micro/nanoscale materials with sphere-like morphologies are prepared via a vapor-transport deposition process. The structure and morphology of the asprepared products are characterized by powder X-ray diffraction and scanning electron microscopy. Vapor-liquid-solid mechanism is proposed to explain the formation of Mg micro/nanospheres on the basis of the experimental results.

  16. Visualization and quantification of deformation processes controlling the mechanical response of alloys in aggressive environments

    Energy Technology Data Exchange (ETDEWEB)

    Robertson, Ian M. [Univ. of Wisconsin, Madison, WI (United States). Dept. of Materials Science and Engineering; Univ. of Illinois, Champaign, IL (United States)


    The overall objective of this program was to develop the technique of electron tomography for studies of defects and to couple it with real time dynamic experiments such that four-dimensional (time and three spatial dimensions) characterization of dislocation interactions with defects is feasible and apply it to discovery of the fundamental unit processes of dislocation-defect interactions in metallic systems. Strategies to overcome the restrictions normally associated with electron tomography and to make it practical within the constraints of conducting a dynamic experiment in the transmission electron microscope were developed. These methods were used to determine the mechanism controlling the transfer of slip across grain boundaries in FCC and HCP metals, dislocation precipitate interactions in Al alloys, and dislocation-dislocation interactions in HCP Ti. In addition, preliminary investigations of slip transfer across cube-on-cube and incoherent twin interfaces in a multi-layered system, thermal stability of grains in nanongrained Ni and Fe, and on corrosion of Fe films were conducted.

  17. Potential mechanisms and environmental controls of TiO2 nanoparticle effects on soil bacterial communities. (United States)

    Ge, Yuan; Priester, John H; Van De Werfhorst, Laurie C; Schimel, Joshua P; Holden, Patricia A


    It has been reported that engineered nanoparticles (ENPs) alter soil bacterial communities, but the underlying mechanisms and environmental controls of such effects remain unknown. Besides direct toxicity, ENPs may indirectly affect soil bacteria by changing soil water availability or other properties. Alternatively, soil water or other environmental factors may mediate ENP effects on soil bacterial communities. To test, we incubated nano-TiO2-amended soils across a range of water potentials for 288 days. Following incubation, the soil water characteristics, organic matter, total carbon, total nitrogen, and respiration upon rewetting (an indicator of bioavailable organic carbon) were measured. Bacterial community shifts were characterized by terminal restriction fragment length polymorphism (T-RFLP). The endpoint soil water holding had been reported previously as not changing with this nano-TiO2 amendment; herein, we also found that some selected soil properties were unaffected by the treatments. However, we found that nano-TiO2 altered the bacterial community composition and reduced diversity. Nano-TiO2-induced community dissimilarities increased but tended to approach a plateau when soils became drier. Taken together, nano-TiO2 effects on soil bacteria appear to be a result of direct toxicity rather than indirectly through nano-TiO2 affecting soil water and organic matter pools. However, such directs effects of nano-TiO2 on soil bacterial communities are mediated by soil water.

  18. Synthesis of nanostructured methotrexate/hydroxyapatite: Morphology control, growth mechanism, and bioassay explore. (United States)

    Dai, Chao-Fan; Li, Shu-Ping; Li, Xiao-Dong


    In this study, a new structure of methotrexate/hydroxyapatite (MTX/HAp) nanorods via a facile hydrothermal route was reported. The as-synthesized samples were then characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), thermogravimetric (TG) and differential scanning calorimetry (DSC) analysis. In order to explore the formation mechanism, the effects of reaction time, MTX concentrations and addition of ethylene glycol (PEG) were emphatically examined. The results indicated that, with the increase in reaction time, the fibrous nanoparticles turned to needle-like and then to rod-like. Our study also proved that reaction time of 12h was enough for the full-growth of the nanostructure. Drug-loading capacities (AIn) rose dramatically in the first 12h and reached a plateau afterwards. Importantly, MTX played a critical role in the longitudinal growth of MTX/HAp nanostructure and polyethylene glyco (PEG) was a good dispersing agent to improve the monodispersity. As expected, the functional agent of MTX was served as both the target anticancer drug loaded in HAp and effective complex agents to modify and control the morphologies of MTX/HAp. Lastly, in vitro bioassay tests gave us evidence that obvious tumor inhibition can be achieved when MTX was hybridized with HAp.

  19. Numerical simulation and experimental validation of the control mechanism of noise and vibration active control devices by piezoceramic transducers

    Energy Technology Data Exchange (ETDEWEB)

    Miccoli, G. [National Research Council, Cassana (Italy). Earth-Moving Machinery and Off-Road Vehicles Inst.; Concilio, A. [C.I.R.A., Capua (Italy)


    The applications till now carried out by this research group in order to actively control structural noise and vibration levels by means of piezoceramic transducers refer to the use and test of simple analogic SISO control systems. These devices work each connected to a couple of sensor/actuator collocated piezoceramics and implement positive feedback control law with self-adaptive variable gain. In order to improve the performance of these control systems and get more insight into their operation, the simulation of the control mechanism itself has been carried out by means of: (a) theoretical analysis of phase and gain characteristics of these devices using finite element (FEM) code (MSC/NASTRAN); (b) experimental validation of the analytical results by means of an on purpose built SISO variable phase and gain control system. On the basis of the experimental results obtained the electronic components of this first SISO control system have been optimized in order to reduce possible instability phenomena.

  20. A methodology for identification and control of electro-mechanical actuators. (United States)

    Tutunji, Tarek A; Saleem, Ashraf


    Mechatronic systems are fully-integrated engineering systems that are composed of mechanical, electronic, and computer control sub-systems. These integrated systems use electro-mechanical actuators to cause the required motion. Therefore, the design of appropriate controllers for these actuators are an essential step in mechatronic system design. In this paper, a three-stage methodology for real-time identification and control of electro-mechanical actuator plants is presented, tested, and validated. First, identification models are constructed from experimental data to approximate the plants' response. Second, the identified model is used in a simulation environment for the purpose of designing a suitable controller. Finally, the designed controller is applied and tested on the real plant through Hardware-in-the-Loop (HIL) environment. The described three-stage methodology provides the following practical contributions: •Establishes an easy-to-follow methodology for controller design of electro-mechanical actuators.•Combines off-line and on-line controller design for practical performance.•Modifies the HIL concept by using physical plants with computer control (rather than virtual plants with physical controllers). Simulated and experimental results for two case studies, induction motor and vehicle drive system, are presented in order to validate the proposed methodology. These results showed that electromechanical actuators can be identified and controlled using an easy-to-duplicate and flexible procedure.

  1. GA-based stable control for a class of underactuated mechanical systems (United States)

    Liu, Diantong; Guo, Weiping; Yi, Jianqiang


    A nonlinear dynamic model of a class of underactuated mechanical systems was built using the Lagrangian method. Some system properties such as the system passivity were analyzed. A GA(Genetic Algorithms)-based stable control algorithm was proposed for the class of underactuated mechanical systems. The Lyapunov stability theory and system properties were utilized to guarantee the system's asymptotic stability to its equilibrium. A real-valued GA was used to adjust the parameters of a stable controller to improve the system performance. An underactuated double-pendulum-type overhead crane system is used to validate the proposed control algorithm. Simulation results illustrate the validity of proposed control algorithm under different conditions.

  2. Mechanical Properties of Water-Assembled Graphene Oxide Langmuir Monolayers: Guiding Controlled Transfer. (United States)

    Harrison, Katharine L; Biedermann, Laura B; Zavadil, Kevin R


    Liquid-phase transfer of graphene oxide (GO) and reduced graphene oxide (RGO) monolayers is investigated from the perspective of the mechanical properties of these films. Monolayers are assembled in a Langmuir-Blodgett trough, and oscillatory barrier measurements are used to characterize the resulting compressive and shear moduli as a function of surface pressure. GO monolayers are shown to develop a significant shear modulus (10-25 mN/m) at relevant surface pressures while RGO monolayers do not. The existence of a shear modulus indicates that GO is acting as a two-dimensional solid driven by strong interaction between the individual GO sheets. The absence of such behavior in RGO is attributed to the decrease in oxygen moieties on the sheet basal plane, permitting RGO sheets to slide across one another with minimum energy dissipation. Knowledge of this two-dimensional solid behavior is exploited to successfully transfer large-area, continuous GO films to hydrophobic Au substrates. The key to successful transfer is the use of shallow-angle dipping designed to minimize tensile stress present during the insertion or extraction of the substrate. A shallow dip angle on hydrophobic Au does not impart a beneficial effect for RGO monolayers, as these monolayers do not behave as two-dimensional solids and do not remain coherent during the transfer process. We hypothesize that this observed correlation between monolayer mechanical properties and continuous film transfer success is more universally applicable across substrate hydrophobicities and could be exploited to control the transfer of films composed of two-dimensional materials.

  3. State of the Art Report for Development of Control Element Drive Mechanism of the APR+ Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jae Seon; Choi, Suhn; Song, Chul Hwa


    Recently newly-developed nuclear reactors with increased safety and enhanced performance by developed countries in the nuclear area are competing in the global nuclear market. Several reactors, for example AP600 and AP1000 by Westinghouse Electric Co. in USA, EPR by Areva in Europe, APWR by Mitsubishi Heavy Industry in Japan in the pressurized power reactor, are competing to preoccupy the nuclear market during Nuclear Renaissance. Dedicated control element drive mechanism with enhanced performance and increased safety are developed for these new reactors. And load follow capability is required, and it is estimated that load follow requirement make design requirement of a control element drive mechanism harsh. It is necessary to review the current technical state of a control element drive mechanism. This work is aimed to review the design characteristics of a past and current control element drive mechanism for a nuclear reactor and to check the direction and goal of CEDM design development recently.

  4. New discrimination method for ablative control mechanism in solid-propellant rocket nozzle

    Institute of Scientific and Technical Information of China (English)


    A reasonable discrimination method for ablative control mechanism in solid-propellant rocket nozzle can improve the calculation accuracy of ablation rate. Based on the different rate constants for reactions of C with H2O and CO2,a new discrimination method for ablative control mechanism,which comprehensively considers the influence of nozzle surface temperature and gas component concentration,is presented. Using this new discrimination method,calculations were performed to simulate the nozzle throat insert ablation. The numerical results showed that the calculated ablation rate,which was more close to the measured values,was less than the value calculated by diffusion control mechanisms or by double control mechanisms. And H2O was proved to be the most detrimental oxidizing species in nozzle ablation.


    Directory of Open Access Journals (Sweden)

    M. A. Ostashkin


    Full Text Available This article discusses the possibility of application of controlling as mechanism of increasing the efficiency of management of enterprises of fuel- energy complex. The research was conducted on the materials of the JSC «Gazprom».

  6. A Rate-Based Flow Control Mechanism for AvoidingCongestion

    Institute of Scientific and Technical Information of China (English)

    张孝林; 王宇宏; 吴介一


    The rate-based flow control mechanisms for the Available Bit Rate (ABR) service are used to share the available bandwidth of a bottleneck switch connected to a bottleneck link fairly and reasonably among many competitive users, and to maintain the buffer queue length of the switch at a desired level in order to avoid congestion in Asynchronous Transfer Mode (ATM) networks. In this paper, a control theoretic approach that uses a DeadbeatResponse (DR) controller to the design of a rate-based flow control mechanism is presented.The mechanism has a simple structure and is robust in the sense that its stability is not sensitive to the change of the number of active Virtual Connections (VCs). Simulation results show that this mechanism not only ensures fair share of the bandwidth for all active VCs regardless of the number of hops they traverse but also has the advantages of fast convergence, no oscillation,and high link bandwidth utilization.

  7. Supplementary Material to: Realization of Three-port Spring Networks with Inerter for Effective Mechanical Control


    Michael Z. Q. Chen; Wang, Kai; Zou, Yun; Chen, Guanrong


    This is a supplementary material to "Realization of three-port spring networks with inerter for effective mechanical control" [1], which provides the detailed proofs of some results. For more background information, refer to [2]-[32] and references therein.

  8. Mechanical characterization of the injured spinal cord after lateral spinal hemisection injury in the rat. (United States)

    Saxena, Tarun; Gilbert, Jeremy; Stelzner, Dennis; Hasenwinkel, Julie


    The glial scar formed at the site of traumatic spinal cord injury (SCI) has been classically hypothesized to be a potent physical and biochemical barrier to nerve regeneration. One longstanding hypothesis is that the scar acts as a physical barrier due to its increased stiffness in comparison to uninjured spinal cord tissue. However, the information regarding the mechanical properties of the glial scar in the current literature is mostly anecdotal and not well quantified. We monitored the mechanical relaxation behavior of injured rat spinal cord tissue at the site of mid-thoracic spinal hemisection 2 weeks and 8 weeks post-injury using a microindentation test method. Elastic moduli were calculated and a modified standard linear model (mSLM) was fit to the data to estimate the relaxation time constant and viscosity. The SLM was modified to account for a spectrum of relaxation times, a phenomenon common to biological tissues, by incorporating a stretched exponential term. Injured tissue exhibited significantly lower stiffness and elastic modulus in comparison to uninjured control tissue, and the results from the model parameters indicated that the relaxation time constant and viscosity of injured tissue were significantly higher than controls. This study presents direct micromechanical measurements of injured spinal cord tissue post-injury. The results of this study show that the injured spinal tissue displays complex viscoelastic behavior, likely indicating changes in tissue permeability and diffusivity.

  9. Characterization of biofoulants illustrates different membrane fouling mechanisms for aerobic and anaerobic membrane bioreactors

    KAUST Repository

    Xiong, Yanghui


    This study compares the membrane fouling mechanisms of aerobic (AeMBR) and anaerobic membrane bioreactors (AnMBR) of the same reactor configuration at similar operating conditions. Although both the AeMBR and AnMBR achieved more than 90% COD removal efficiency, the fouling mechanisms were different. Molecular weight (MW) fingerprint profiles showed that a majority of fragments in anaerobic soluble microbial products (SMP) were retained by the membrane and some fragments were present in both SMP and in soluble extracellular polymeric substances (EPS), suggesting that the physical retention of SMP components contributed to the AnMBR membrane fouling. One of the dominant fragments was comprised of glycoliproprotein (size 630-640 kD) and correlated in abundance in AnMBR-EPS with the extent of anaerobic membrane fouling. In contrast, all detected AeMBR-SMP fragments permeated through the membrane. Aerobic SMP and soluble EPS also showed very different fingerprinting profiles. A large amount of adenosine triphosphate was present in the AeMBR-EPS, suggesting that microbial activity arising from certain bacterial populations, such as unclassified Comamonadaceae and unclassified Chitinophagaceae, may play a role in aerobic membrane fouling. This study underlines the differences in fouling mechanisms between AeMBR and AnMBR systems and can be applied to facilitate the development of appropriate fouling control strategies.

  10. Mechanical characterization of an electrostrictive polymer for actuation and energy harvesting (United States)

    Eddiai, A.; Meddad, M.; Touhtouh, S.; Hajjaji, A.; Boughaleb, Y.; Guyomar, D.; Belkhiat, S.; Sahraoui, B.


    Electroactive polymers have been widely used as smart material for actuators in recent years. Electromechanical applications are currently focused on energy harvesting and actuation, including the development of wireless portable electronic equipment autonomous and specific actuators such as artificial muscles. The problem to be solved is to make its devices the most efficient, as possible in terms of harvested energy and action. These two criteria are controlled by the permittivity of the electrostrictive polymer used, the Young's modulus, and their dependence on frequency and level of stress. In the present paper, we presented a model describing the mechanical behaviour of electrostrictive polymers with taking into account the mechanical losses. Young's modulus follows a linear function of strain and stress. However, when the elongation becomes higher, the data obtained from this strain linear trend and significant hysteresis loops appear the reflections on the existence of mechanical losses. In this work, to provide the analysis of the experimental observations, we utilized a theoretical model in order to define a constitutive law implying a representative relationship between stress and strain. After detailing this theoretical model, the simulation results are compared with experimental ones. The results show that hysteresis loss increases with the increase of frequency and strain amplitude. The model used here is in good agreement with the experimental results.

  11. Noether-Form Invariance of Nonholonomic Controllable Mechanical Systems in Phase Space

    Institute of Scientific and Technical Information of China (English)

    XIA Li-Li; LI Yuan-Cheng


    In this paper, we study the Noether-form invariance of nonholonomic mechanical controllable systems in phase space. Equations of motion of the controllable mechanical systems in phase space are presented. The definition and the criterion for this system are presented. A new conserved quantity and the Noether conserved quantity deduced from the Noether-form invariance are obtained. An example is given to illustrate the application of the results.

  12. Study on the control mechanism of China aerospace enterprises' binary multinational operation

    Institute of Scientific and Technical Information of China (English)

    Wang Jian; Li Hanling; Wu Weiwei


    China's aerospace enterprises carry on the multinational operation and participate in the international competition and the international division of labor and cooperation positively.This article first analyzs China aerospace enterprises' binary multinational business control objective and constructes its model.Then the article analyzes the tangible and intangible control mechanism of China aerospace enterprises' binary multinational operation respectively.Finally,the article constructs the model of China aerospace enterprises' binary multinational operation mechanisms.

  13. Control of Underactuated Mechanical Systems : Observer Design and Position Feedback Stabilization

    NARCIS (Netherlands)

    Venkatraman, Aneesh; Ortega, Romeo; Sarras, Ioannis; Schaft, Arjan van der


    We identify a class of mechanical systems for which a globally exponentially stable reduced order observer can be designed. The class is characterized by (the solvability of) a set of partial differential equations and contains all systems that can be rendered linear in (the unmeasurable) momenta vi

  14. Networked Just-in-time Control of a Parallel Mechanism with Pneumatic Linear Drives

    Directory of Open Access Journals (Sweden)

    Takahiro Kosaki


    Full Text Available Parallel mechanisms have advantages such as high power, high stiffness, and high precision due to the parallel arrangement of actuators, in comparison with typical serial mechanisms. In the present study, we used pneumatic linear drives to develop a linearly actuated parallel mechanism, in which the actuators fixed on a base enable high degrees of freedom of motion of an end-effector. Using pneumatic linear drives in the realization of such a parallel mechanism leads to lightweight, compact, and low-cost construction. For the parallel mechanism prototype, we construct a control system based on our previously proposed networked Just-In-Time (JIT control strategy, which is based on client-server architecture. In this system, the parallel mechanism is connected to a client computer, and a server computer has a database that stores the control data for all the pneumatic actuators to drive the parallel mechanism. The client online accesses the database, receives data from the server, and feeds control commands to the pneumatic actuators. Experiments were performed to investigate the performance of the developed parallel mechanism system.

  15. The Dynamic Evolution of Firms’ Pollution Control Strategy under Graded Reward-Penalty Mechanism

    Directory of Open Access Journals (Sweden)

    Li Ming Chen


    Full Text Available The externality of pollution problem makes firms lack enough incentive to reduce pollution emission. Therefore, it is necessary to design a reasonable environmental regulation mechanism so as to effectively urge firms to control pollution. In order to inspire firms to control pollution, we divide firms into different grades according to their pollution level and construct an evolutionary game model to analyze the interaction between government’s regulation and firms’ pollution control under graded reward-penalty mechanism. Then, we discuss stability of firms’ pollution control strategy and derive the condition of inspiring firms to control pollution. Our findings indicate that firms tend to control pollution after long-term repeated games if government’s excitation level and monitoring frequency meet some conditions. Otherwise, firms tend to discharge pollution that exceeds the stipulated standards. As a result, in order to effectively control pollution, a government should adjust its excitation level and monitoring frequency reasonably.

  16. Pressure- and flow-controlled media perfusion differently modify vascular mechanics in lung decellularization. (United States)

    da Palma, Renata K; Campillo, Noelia; Uriarte, Juan J; Oliveira, Luis V F; Navajas, Daniel; Farré, Ramon


    Organ biofabrication is a potential future alternative for obtaining viable organs for transplantation. Achieving intact scaffolds to be recellularized is a key step in lung bioengineering. Perfusion of decellularizing media through the pulmonary artery has shown to be effective. How vascular perfusion pressure and flow vary throughout lung decellularization, which is not well known, is important for optimizing the process (minimizing time) while ensuring scaffold integrity (no barotrauma). This work was aimed at characterizing the pressure/flow relationship at the pulmonary vasculature and at how effective vascular resistance depends on pressure- and flow-controlled variables when applying different methods of media perfusion for lung decellularization. Lungs from 43 healthy mice (C57BL/6; 7-8 weeks old) were investigated. After excision and tracheal cannulation, lungs were inflated at 10 cmH2O airway pressure and subjected to conventional decellularization with a solution of 1% sodium dodecyl sulfate (SDS). Pressure (PPA) and flow (V'PA) at the pulmonary artery were continuously measured. Decellularization media was perfused through the pulmonary artery: (a) at constant PPA=20 cmH2O or (b) at constant V'PA=0.5 and 0.2 ml/min. Effective vascular resistance was computed as Rv=PPA/V'PA. Rv (in cmH2O/(ml/min)); mean±SE) considerably varied throughout lung decellularization, particularly for pressure-controlled perfusion (from 29.1±3.0 in baseline to a maximum of 664.1±164.3 (pperfusion (from 49.9±3.3 and 79.5±5.1 in baseline to a maximum of 114.4±13.9 and 211.7±70.5 (pperfusion mechanics throughout decellularization provides information relevant for optimizing the process time while ensuring that vascular pressure is kept within a safety range to preserve the organ scaffold integrity.

  17. Characterization and adaptive fuzzy model reference control for a magnetic levitation system

    Directory of Open Access Journals (Sweden)

    J.J. Hernández-Casañas


    Full Text Available This paper shows the implementation of a fuzzy controller applied for magnetic levitation, to make this, the characterization of the magnetic actuator was computed by using ANSYS® analysis. The control law was a Mamdani PD implemented with two microcontrollers, to get a smooth control signal, it was used a model reference. A learning scheme was used to update the consequents of the fuzzy rules. Different reference signals and disturbances were applied to the system to show the robustness of the controller. Finally, LabVIEW® was used to plot the results.

  18. Mechanical Characterization of the Human Lumbar Intervertebral Disc Subjected to Impact Loading Conditions (United States)

    Jamison, David, IV

    Low back pain is a large and costly problem in the United States. Several working populations, such as miners, construction workers, forklift operators, and military personnel, have an increased risk and prevalence of low back pain compared to the general population. This is due to exposure to repeated, transient impact shocks, particularly while operating vehicles or other machinery. These shocks typically do not cause acute injury, but rather lead to pain and injury over time. The major focus in low back pain is often the intervertebral disc, due to its role as the major primary load-bearing component along the spinal column. The formation of a reliable standard for human lumbar disc exposure to repeated transient shock could potentially reduce injury risk for these working populations. The objective of this project, therefore, is to characterize the mechanical response of the lumbar intervertebral disc subjected to sub-traumatic impact loading conditions using both cadaveric and computational models, and to investigate the possible implications of this type of loading environment for low back pain. Axial, compressive impact loading events on Naval high speed boats were simulated in the laboratory and applied to human cadaveric specimen. Disc stiffness was higher and hysteresis was lower than quasi-static loading conditions. This indicates a shift in mechanical response when the disc is under impact loads and this behavior could be contributing to long-term back pain. Interstitial fluid loss and disc height changes were shown to affect disc impact mechanics in a creep study. Neutral zone increased, while energy dissipation and low-strain region stiffness decreased. This suggests that the disc has greater clinical instability during impact loading with progressive creep and fluid loss, indicating that time of day should be considered for working populations subjected to impact loads. A finite element model was developed and validated against cadaver specimen

  19. Microcontroller Based Proportional Derivative Plus Conditional Integral Controller for Electro-Mechanical Dual Acting Pulley Continuously Variable Transmission Ratio Control (United States)

    Budianto, A.; Tawi, K. B.; Hussein, M.; Supriyo, B.; Ariyono, S.; Che Kob, M. S.; Ezlamy Zulkifli, Mohd; K, Khairuldean A.; Daraoh, Aishah


    Electro-Mechanical Dual Acting Pulley (EMDAP) Continuously Variable Transmission (CVT) is a transmission utilized by electro-mechanical actuated system. It has a potential to reduce energy consumption because it only needs power during changing CVT ratio and no power is needed to maintain CVT ratio due to self lock mechanism design. This paper proposed simple proportional derivative plus conditional integral (PDCI) controller to control EMDAP CVT ratio which can be simply implemented on a microcontroller. This proposed controller used Astrom-Hagglund method and Ziegler-Nichols formula to tune PDCI gain. The Proportional Derivative controller is directly activated from the start but Integral controller is only activated when the error value reaches error value setting point. Simulation using Matlab/Simulink software was conducted to evaluate PDCI system performance. The simulation results showed PDCI controller has ability to perform maximum overshoot 0.1%, 0.001 steady state error and 0.5s settling time. For clamping condition, settling time is about 11.46s during changing ratio from 2.0 to 0.7, while for release condition, settling time is about 8.33s during changing ratio from 0.7 to 2.0.

  20. A Closed-Loop Proportional-Integral (PI) Control Software for Fully Mechanically Controlled Automated Electron Microscopic Tomography

    Energy Technology Data Exchange (ETDEWEB)


    A closed-loop proportional-integral (PI) control software is provided for fully mechanically controlled automated electron microscopic tomography. The software is developed based on Gatan DigitalMicrograph�, and is compatible with Zeiss LIBRA� 120 transmission electron microscope. However, it can be expanded to other TEM instrument with modification. The software consists of a graphical user interface, a digital PI controller, an image analyzing unit, and other drive units (i.e.: image acquire unit and goniometer drive unit). During a tomography data collection process, the image analyzing unit analyzes both the accumulated shift and defocus value of the latest acquired image, and provides the results to the digital PI controller. The digital PI control compares the results with the preset values and determines the optimum adjustments of the goniometer. The goniometer drive unit adjusts the spatial position of the specimen according to the instructions given by the digital PI controller for the next tilt angle and image acquisition. The goniometer drive unit achieves high precision positioning by using a backlash elimination method. The major benefits of the software are: 1) the goniometer drive unit keeps pre-aligned/optimized beam conditions unchanged and achieves position tracking solely through mechanical control; 2) the image analyzing unit relies on only historical data and therefore does not require additional images/exposures; 3) the PI controller enables the system to dynamically track the imaging target with extremely low system error.