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Sample records for characterization study progress

  1. Recent progress in volcanism studies: Site characterization activities for the Yucca Mountain site characterization project

    International Nuclear Information System (INIS)

    Significant progress has been made on volcanism studies over the past calendar year. There are a number of major highlights from this work. Geochronology data have been obtained for the Lathrop Wells center using a range of isotopic, radiogenic, and age-calibrated methods. Initial work is encouraging but still insufficient to resolve the age of the center with confidence. Geologic mapping of the Sleeping Butte volcanic centers was completed and a report issued on the geology and chronology data. Twenty shallow trenches have been constructed in volcanic units of the Lathrop Wells volcanic center. Results of detailed studies of the trenches support a polycyclic eruptive history. New soil data from the trenches continue to support a late Pleistocene or Holocene age for many of the volcanic units at the center. Geochemical data (trace element and isotopic analysis) show that the volcanic units of the Lathrop Wells center cannot be related to one another by fractional crystallization of a single magma batch, supporting a polycyclic model of volcanism. Structural models using existing data are used to evaluate the probability of magmatic disruption of a potential repository. Several permissive models have been developed but none lead to significant differences in calculating the disruption ratio. Work was initiated on the eruptive and subsurface effects of magmatic activity on a repository. (author)

  2. Characterization of dopaminergic dysfunction in familial progressive supranuclear palsy: an 18F-dopa PET study

    International Nuclear Information System (INIS)

    We analyzed 18F-dopa PET data from 11 members of kindreds with familial progressive supranuclear palsy (PSP) to characterize their cerebral dopaminergic dysfunction. Three clinically-affected PSP patients showed reduced 18F-dopa uptake in the striatum, orbitofrontal cortex and amygdala. One asymptomatic subject exhibited progressive putamen dopaminergic dysfunction. 60 % of subjects with abnormal 18F-dopa scans developed PSP subsequently. This is the first in vivo documentation of cortical dopaminergic deficiency in PSP. Reduced striatal 18F-dopa uptake in susceptible relatives may predict later clinical disease. (author)

  3. Mineralogical characterization of selected shales in support of nuclear waste repository studies: Progress report

    International Nuclear Information System (INIS)

    Because baseline characterization of shale mineralogy is critical to the interpretation of results from experiments on radionuclide retardation, groundwater-shale interactions, and physicochemical characteristics, a protocol for quantitative mineralogical analyses has been developed by integrating geochemical and instrumental techniques for the investigation of properties related to repository performance. Thermal analyses were used to estimate total organic matter and carbonate mineral contents. Scanning electron microscope backscattering and elemental mapping of polished sectors and particle-size distribution data were used to estimate the amounts of quartz plus feldspar and pyrite in the shales. X-ray diffraction, neutron activation, and size-distribution data were utilized to estimate phyllosilicate mineral contents. High-resolution transmission electron microscopy was used to identify clay mineral components

  4. Characterization of plant plasma membrane antigens. Progress report

    International Nuclear Information System (INIS)

    The library of monoclonal antibodies, which are directed against membrane bound antigens of protoplast plasma membrane, are being characterized by immunoprecipitation, immunoaffinity chromatography, and by Western blotting of SDS gels. Progress on these studies is reported here. (DT)

  5. Site Characterization Progress Report Number 21

    Energy Technology Data Exchange (ETDEWEB)

    None

    1999-09-30

    This is the 21 st progress report issued by the U.S. Department of Energy. This report provides a summary-level discussion of Yucca Mountain Site Characterization Project progress. Accomplishments this period are presented in a format that identifies important progress achieved and conveys how that progress supports the near-term objectives in the U.S. Department of Energy's schedule. Greater detail is documented in the cited references and in deliverables listed in Appendix A to this report. This document provides a discussion of recently completed and ongoing activities conducted by the Yucca Mountain Site Characterization Project during the six-month reporting period from April 1, 1999, through September 30, 1999. Some information presented herein is by necessity preliminary, because some deliverables and reports that support the discussions have not been finalized. Projected future deliverables and reports are listed in Appendix B and are noted in the text as works in progress. Appendix C lists the status of milestone reports referenced in previous progress reports commencing with Progress Report 17. A glossary of Yucca Mountain Site Characterization Project-specific terms used in this report is given in Appendix D.

  6. Site Characterization Progress Report No.20

    Energy Technology Data Exchange (ETDEWEB)

    DOE

    1999-10-01

    This is the 20th progress report issued by the U.S. Department of Energy. This report provides a summary-level discussion of Yucca Mountain Site Characterization Project progress. Accomplishments this period are presented in a format that identifies important progress achieved and conveys how that progress supports the near-term objectives in the U.S. Department of Energy's schedule. Greater detail is documented in the cited references and in deliverables listed in Appendix A to this report. Readers may request specific U.S. Department of Energy-approved program documents that are listed in Section 7, References, and Appendix A by contacting the Office of Civilian Radioactive Waste Management Information Line at 1-800-225-6972. This document provides a discussion of recently completed and ongoing activities conducted by the Yucca Mountain Site Characterization Project during the six-month reporting period from October 1, 1998, through March 31, 1999. Some information presented herein is by necessity preliminary, because some deliverables and reports that support the discussions have not been finalized. Projected future deliverables and reports are listed in Appendix B and are noted in the text as works in progress. Appendix C lists the status of milestone reports referenced in previous progress reports. A glossary of Yucca Mountain Site Characterization Project-specific terms used in this report is given in Appendix D.

  7. Progresses in proton radioactivity studies

    Science.gov (United States)

    Ferreira, L. S.; Maglione, E.

    2016-07-01

    In the present talk, we will discuss recent progresses in the theoretical study of proton radioactivity and their impact on the present understanding of nuclear structure at the extremes of proton stability.

  8. Progress in Aridification Studies

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ A national key project entitled "Predictive study of aridification in northern China in association with life-supporting environment changes" has recently passed the appraisal of a panel organized by the Ministry of Science & Technology in Beijing.

  9. Incorporating Disciplinary Practices Into Characterizations of Progress in Responsive Teaching

    CERN Document Server

    Richards, Jennifer; Gupta, Ayush

    2015-01-01

    Responsive teaching, in which teachers adapt instruction based on close attention to the substance of students' ideas, is typically characterized along two dimensions: the level of detail at which teachers attend and respond to students' ideas, and the stance teachers take toward what they hear - evaluating for correctness vs. interpreting meaning. We propose that characterizations of progress in responsive teaching should also consider the disciplinary centrality of the practices teachers notice and respond to within student thinking. To illustrate what this kind of progress can look like, we present a case study of a middle school science teacher who implemented the "same" lesson on the motion of freely falling objects in two subsequent years. We argue that his primary shift in responsiveness stemmed from a shift in which disciplinary practices he preferentially noticed and foregrounded. He moved from a focus on causal factors or variables to a more scientifically productive focus on causal stories or expla...

  10. Identification and characterization of conservative organic tracers for use as hydrologic tracers for the Yucca Mountain Site Characterization Study; Progress report, June 1--December 31, 1990

    Energy Technology Data Exchange (ETDEWEB)

    Stetzenbach, K.J.

    1990-12-31

    Ground water tracers are solutes dissolved in or carried by ground water to delineate flow pathways. Tracers provide information on direction and speed of water movement and that of contaminants that might be conveyed by the water. Tracers can also be used to measure effective porosity, hydraulic conductivity, dispersivity and solute distribution coefficients. For most applications tracers should be conservative, that is, move at the same rate as the water and not sorb to aquifer materials. Tracers must have a number of properties to be functional. Regardless of the desired properties, the chemical and physical behavior of a tracer in ground water and the porous medium under study must be understood. Good estimates of tracer behavior can be obtained from laboratory studies. Studies in this proposal will address tracer properties with analytical method development, static sorption and degradation studies and column transport studies, Mutagenicity tests will be performed on promising candidates. The tracers that will be used for these experiments are fluorinated organic acids and other organic compounds that have the chemical and biological stability necessary to be effective in the Yucca Mountain environment. Special emphasis will be placed on compounds that fluoresce or have very large ultraviolet absorption coefficients for very high analytical sensitivity.

  11. Progress on HELIAS systems studies

    Energy Technology Data Exchange (ETDEWEB)

    Warmer, Felix; Beidler, Craig D.; Dinklage, Andreas; Feng, Yuehe; Geiger, Joachim; Schauer, Felix; Turkin, Yuriy; Wolf, Robert; Xanthopoulos, Pavlos [Max-Planck-Institut fuer Plasmaphysik, D-17491 Greifswald (Germany); Kemp, Richard; Knight, Peter; Ward, David [Culham Centre for Fusion Energy, Abingdon, Oxfordshire, OX14 3DB (United Kingdom)

    2015-05-01

    In order to study and design next-step fusion devices such as DEMO, comprehensive systems codes are commonly employed. For the HELIAS-line, stellarator-specific models have been developed, implemented, and verified within the systems code PROCESS. This systems code ansatz is complemented by self-consistent modeling of plasma scenarios employing a predictive 1-D neoclassical transport code which has been augmented with a model for the edge anomalous transport based on 3-D ITG turbulence simulations. This approach is investigated to ultimately allow one to conduct stellarator system studies, develop design points of HELIAS burning plasma devices, and to facilitate a direct comparison between tokamak and stellarator DEMO and power plant designs. The work reports on the progress towards these goals.

  12. Progress in Helias reactor studies

    International Nuclear Information System (INIS)

    The Helias reactor is an upgraded version of the Wendelstein 7-X experiment, which is under construction in the city of Greifswald. The modular coil system comprises 50 coils, which are constructed using NbTi-superconducting cables. The basic dimensions are: major radius 22 m, average plasma radius 1.8 m, magnetic field on axis 5 T, maximum field on coils 10 T. Over the past year progress toward better understanding of the fusion plasma has been made. In particular, the following issues have been addressed: Plasma equilibrium and MHD-stability; Neoclassical transport in the Helias configuration; Start-up scenarios and steady state burn; Alpha-particle orbits and alpha-particle losses; Drift waves in Helias configurations; Modelling the fusion plasma using empirical scaling laws Technical studies have been focussed on the optimization of the coil system with respect to magnetic field distribution, forces and stresses. In this context the ANSYS-code has been found useful for optimising the support system. In a first survey several blanket concepts, developed for the DEMO tokamak, have been adapted to the Helias geometry. Presently a water-cooled LiPb-blanket is favored in comparison with ceramic breeders, since safety properties and maintenance procedure seem to be more advantageous within this concept. Maintenance and replacement of blanket segments through portholes have also been studied with respect to their geometric compatibility. Finally parameter studies of low aspect ratio Helias reactors will be discussed. (orig.)

  13. Nuclear spectroscopic studies. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Bingham, C.R.; Riedinger, L.L.; Sorensen, S.P.

    1996-01-16

    This report describes progress in the experimental nuclear physics program of the University of Tennessee, Knoxville. It presents findings related to properties of high-spin states, low-energy levels of nuclei far from stability, and high-energy heavy-ion physics, as well as a brief description of the Joint Institute of Heavy Ion Research (a collaboration between the University of Tennessee, Vanderbilt University, and Oak Ridge National Laboratory) and its activities (particularly those of the last few years), and a list of publications. 89 refs., 18 figs., 5 tabs.

  14. Nuclear spectroscopic studies. Progress report

    International Nuclear Information System (INIS)

    This report describes progress in the experimental nuclear physics program of the University of Tennessee, Knoxville. It presents findings related to properties of high-spin states, low-energy levels of nuclei far from stability, and high-energy heavy-ion physics, as well as a brief description of the Joint Institute of Heavy Ion Research (a collaboration between the University of Tennessee, Vanderbilt University, and Oak Ridge National Laboratory) and its activities (particularly those of the last few years), and a list of publications. 89 refs., 18 figs., 5 tabs

  15. Characterization of Retinal Disease Progression in a 1-Year Longitudinal Study of Eyes With Mild Nonproliferative Retinopathy in Diabetes Type 2

    DEFF Research Database (Denmark)

    Ribeiro, Luisa; Bandello, Francesco; Tejerina, Amparo Navea;

    2015-01-01

    PURPOSE: To identify eyes of patients with diabetes type 2 that show progression of retinal disease within a 1-year period using noninvasive techniques. METHODS: Three hundred seventy-four type 2 diabetic patients with mild nonproliferative diabetic retinopathy (Early Treatment Diabetic Retinopat...

  16. Studies of human mutation rates: Progress report

    International Nuclear Information System (INIS)

    Progress was recorded between January 1 and July 1, 1987 on a project entitled ''Studies of Human Mutation Rates''. Studies underway include methodology for studying mutation at the DNA level, algorithms for automated analyses of two-dimensional polyacrylamide DNA gels, theoretical and applied population genetics, and studies of mutation frequency in A-bomb survivors

  17. Progress in urban dispersion studies

    DEFF Research Database (Denmark)

    Batchvarova, E.; Gryning, Sven-Erik

    2006-01-01

    The present Study addresses recent achievements in better representation Of the urban area structure in meteorology and dispersion parameterisations. The setup and Main Outcome of several recent dispersion experiments in Urban areas and their use in model validation are discussed. The maximum con...

  18. Fusion Studies Program. Progress report

    International Nuclear Information System (INIS)

    Continuation of work in two areas, impurity control and transient electromagnetics, is proposed. In the tokamak impurity control area, an innovative supplemental mechanism, NB-driven impurity flow reversal, has been developed partly under this contract; and the proposed effort is aimed at completing this development, verifying the methodology by comparison with experiment and evaluating its potential in future tokamak experiments. In the tokamak transient electromagnetics area, the proposed effort is aimed at developing a new and more efficient methodology for calculating the currents and resulting magnetic fields in the torus structure and coil systems, which will allow a detailed representation of the latter that can be coupled to the distributed-current plasma model that was implemented for vertical stability and disruption control studies in previous work under this contract; and the application of this methodology to study the control of vertical instabilities and disruptions

  19. Nuclear spectroscopic studies: Progress report

    International Nuclear Information System (INIS)

    Research efforts of the University of Tennessee Nuclear Physics Group can be divided into five broad categories; the structure of nuclei at high angular momentum, nuclear structure and reactions with heavy ions, studies of low-energy levels of nuclei far from stability, nuclear physics with ultrarelativistic particles, and nuclear structure and reaction theory. Within these five broad categories, forty separate research projects are summarized. In addition, development and organization projects are reviewed and a list of publications is provided

  20. Nuclear spectroscopic studies. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Bingham, C.R.; Guidry, M.W.; Riedinger, L.L.; Sorensen, S.P.

    1994-02-18

    The Nuclear Physics group at UTK is involved in heavy-ion physics including both nuclear structure and reaction mechanisms. During the last year experimental work has been in 3 broad areas: structure of nuclei at high angular momentum, structure of nuclei far from stability, and ultra-relativistic heavy-ion physics. Results in these areas are described in this document under: properties of high-spin states, study of low-energy levels of nuclei far from stability, and high-energy heavy-ion physics (PHENIX, etc.). Another important component of the work is theoretical interpretation of experimental results (Joint Institute for Heavy Ion Research).

  1. Accelerator research studies. Progress report

    International Nuclear Information System (INIS)

    The major goal of this project is to study the effects that lead to emittance growth and limitation of beam current and brightness in periodic focusing systems (including linear accelerators). This problem is of great importance for all accelerator applications requiring high intensity beams with small emittance such as heavy ion fusion, spallation neutron sources and high energy physics. In the latter case, future machines must not only provide higher energies (in the range of 10 to 100 TeV), but also higher luminosities than the existing facilities. This implies considerably higher phase-space density of the particle beam produced by the injector linac, i.e., the detrimental emittance growth and concurrent beam loss observed in existing linacs must be avoided

  2. Nuclear spectroscopic studies. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Bingham, C.R.; Guidry, M.W.; Riedinger, L.L.; Sorensen, S.P.

    1993-02-08

    The Nuclear Physics group at the University of Tennessee, Knoxville is involved in several aspects of heavy-ion physics including both nuclear structure and reaction mechanisms. While our main emphasis is on experimental problems involving heavy-ion accelerators, we have maintained a strong collaboration with several theorists in order to best pursue the physics of our measurements. During the last year we have led several experiments at the Holifield Heavy Ion Research Facility and participated in others at Argonne National Laboratory. Also, we continue to be very active in the collaboration to study ultra-relativistic heavy ion physics utilizing the SPS accelerator at CERN in Geneva, Switzerland and in a RHIC detector R&D project. Our experimental work is in four broad areas: (1) the structure of nuclei at high angular momentum, (2) heavy-ion induced transfer reactions, (3) the structure of nuclei far from stability, and (4) ultra-relativistic heavy-ion physics. The results of studies in these particular areas will be described in this document in sections IIA, IIB, IIC, and IID, respectively. Areas (1), (3), and (4) concentrate on the structure of nuclear matter in extreme conditions of rotational motion, imbalance of neutrons and protons, or very high temperature and density. Area (2) pursues the transfer of nucleons to states with high angular momentum, both to learn about their structure and to understand the transfer of particles, energy, and angular momentum in collisions between heavy ions. An important component of our program is the strong emphasis on the theoretical aspects of nuclear structure and reactions.

  3. Nuclear spectroscopic studies: Progress report

    International Nuclear Information System (INIS)

    The Nuclear Physics Group at the University of Tennessee, Knoxville (UTK) is involved in several aspects of heavy-ion physics including both nuclear structure and reaction mechanisms. While our main emphasis is on experimental problems involving heavy-ion accelerators, we have maintained a strong collaboration with several theorists in order to best pursue the physics of our measurements. During the last year we have led experiments at the Holifield Heavy Ion Research Facility (HHIRF) and the Niels Bohr Institute Tandem Accelerator. Also, we are active in a collaboration (WA80) to study ultra-relativistic heavy ion physics utilizing the SPS accelerator at CERN in Geneva, Switzerland. Our experimental work is four broad areas: (1) the structure of nuclei at high angular momentum, (2) heavy-ion induced transfer reactions, (3) the structure of nuclei far from stability, and (4) ultra-relativistic heavy-ion physics. These results will be described in this document. Areas (1), (3), and (4) concentrate on the structure of nuclear matter in extreme conditions of rotational motion, imbalance of neutrons and protons, or very high temperature and density. Area (2) pursues the transfer of nucleons to states with high angular momentum, both to learn about their structure and to understand the transfer of particles, energy, and angular momentum in collisions between heavy ions. An important component of our program is the strong emphasis on the theoretical aspects of nuclear structure and reactions

  4. Progress Toward Characterization of Juvenile Materials in Lunar Pyroclatic Deposits

    Science.gov (United States)

    Gaddis, L. R.

    1999-01-01

    In recent analyses, the 5-band Clementine UV-VIS data have been used to examine the compositions of lunar pyroclastic deposits. A primary goal of these analyses has been the characterization of the primary volcanic or juvenile components of these deposits. The compositions, physical and morphological characteristics, and spatial distributions of juvenile volcanic materials provide information on the distribution of primary mafic materials on the Moon, conditions required for their eruption at the surface, and the behavior of lunar volcanic processes over time. Using current analytical techniques with the new Clementine UV-VIS global mosaic, and data from the GLGM2 geophysical models, to supplement ongoing work with Earth-based spectral reflectance analyses and laboratory investigations, we have adopted a three-pronged approach to these issues involving: (1) compositional analyses of lunar pyroclastic deposits; (2) characterization of the relations between effusive and explosive lunar volcanism; and (3) examination of the global occurrence and distribution of lunar pyroclastic deposits. This report and related work describe progress toward remote characterization of the compositions of juvenile materials in the pyroclastic deposits located at Taurus-Littrow and J. Herschel. These studies have implications for characterization of the relations between the products of effusive and explosive volcanism on the Moon. Analyses of lunar pyroclastic materials, primarily the juvenile picritic glasses, provide unique information on the composition of the mantle and on the nature and origin of associated volatile elements in an otherwise volatile-depleted environment. Possible fundamental differences between picritic glasses and mare basalts, (e.g., lesser fractional crystallization and greater depth of origin for glasses) support their identification as the best examples of primitive materials on the Moon, and attest to their importance in characterizing the lunar interior and

  5. Site characterization progress report: Yucca Mountain, Nevada, April 1, 1990--September 30, 1990, Number 3

    International Nuclear Information System (INIS)

    In accordance with the requirements of Section 113(b)(3) of the Nuclear Waste Policy Act of 1982 (NWPA), as amended, the US Department of Energy has prepared this report on the progress of site characterization activities at Yucca Mountain, Nevada, for the period April 1 through September 30, 1990. This report is the third of a series of reports that are issued at intervals of approximately six months during site characterization. The report covers a number of new initiatives to improve the effectiveness of the site characterization program and covers continued efforts related to preparatory activities, study plans, and performance assessment. 85 refs., 2 figs., 3 tabs

  6. Site characterization progress report: Yucca Mountain, Nevada, October 1, 1990--March 31, 1991

    International Nuclear Information System (INIS)

    In accordance with the requirements of Section 113 (b) (3) of the Nuclear Waste Policy Act of 1982, as amended (NWPA), the US Department of Energy (DOE) has prepared this report on the progress of site characterization activities at Yucca Mountain, Nevada, for the period October 1, 1990, through March 31, 1991. This report is the fourth in a series of reports that are issued at intervals of approximately six months during site characterization. The report covers a number of initiatives to improve the effectiveness of the site characterization program, and covers continued efforts related to preparatory activities, Study Plans, and performance assessment

  7. Site characterization progress report: Yucca Mountain, Nevada, October 1, 1990--March 31, 1991; Number 4

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-10-01

    In accordance with the requirements of Section 113 (b) (3) of the Nuclear Waste Policy Act of 1982, as amended (NWPA), the US Department of Energy (DOE) has prepared this report on the progress of site characterization activities at Yucca Mountain, Nevada, for the period October 1, 1990, through March 31, 1991. This report is the fourth in a series of reports that are issued at intervals of approximately six months during site characterization. The report covers a number of initiatives to improve the effectiveness of the site characterization program, and covers continued efforts related to preparatory activities, Study Plans, and performance assessment.

  8. Adhesive Characterization and Progressive Damage Analysis of Bonded Composite Joints

    Science.gov (United States)

    Girolamo, Donato; Davila, Carlos G.; Leone, Frank A.; Lin, Shih-Yung

    2014-01-01

    The results of an experimental/numerical campaign aimed to develop progressive damage analysis (PDA) tools for predicting the strength of a composite bonded joint under tensile loads are presented. The PDA is based on continuum damage mechanics (CDM) to account for intralaminar damage, and cohesive laws to account for interlaminar and adhesive damage. The adhesive response is characterized using standard fracture specimens and digital image correlation (DIC). The displacement fields measured by DIC are used to calculate the J-integrals, from which the associated cohesive laws of the structural adhesive can be derived. A finite element model of a sandwich conventional splice joint (CSJ) under tensile loads was developed. The simulations indicate that the model is capable of predicting the interactions of damage modes that lead to the failure of the joint.

  9. Effects of curriculum organisation on study progress in engineering studies

    NARCIS (Netherlands)

    van der Hulst, M.; Jansen, E.P.W.A.

    2002-01-01

    Procrastination and time investment are important issues in the study of student performance and progress. Previous research on these issues has mainly concentrated upon individual differences between students in personality and time management skills. However, study progress depends not only on stu

  10. Site characterization progress report: Yucca Mountain, Nevada. Progress report number 17, April 1, 1997--September 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    The US Department of Energy`s (DOE) Office of Civilian Radioactive Waste Management (OCRWM), created with the enactment of the Nuclear Waste Policy Act of 1982 (NWPA), is tasked to accept and dispose of the nation`s high-level radioactive waste and spent nuclear fuel in a deep geologic repository (high-level radioactive waste program). The report summarizes significant site characterization activities during the period from April 1, 1997 through September 30, 1997, in the evaluation of Yucca Mountain as a potential site for the geologic disposal of spent nuclear fuel and high-level radioactive wastes. The progress report also cites technical reports and research products that provide the detailed information on these activities. Chapter 2 outlines technical and regulatory issues that must be addressed by the Project and planned work toward achieving future objectives concerning the viability assessment, the environmental impact statement, the site recommendation, and the license application. Chapter 3 describes technical progress in preclosure radiological safety analysis, postclosure performance assessment, and performance confirmation activities. Chapter 4 describes various aspects of repository and waste package design and construction. It also discusses the Exploration Studies Facility cross drift. Chapter 5 describes site characterization activities, and Chapter 6 contains a complete list of references.

  11. Site characterization progress report: Yucca Mountain, Nevada. Progress report number 17, April 1, 1997 - September 30, 1997

    International Nuclear Information System (INIS)

    The US Department of Energy's (DOE) Office of Civilian Radioactive Waste Management (OCRWM), created with the enactment of the Nuclear Waste Policy Act of 1982 (NWPA), is tasked to accept and dispose of the nation's high-level radioactive waste and spent nuclear fuel in a deep geologic repository (high-level radioactive waste program). The report summarizes significant site characterization activities during the period from April 1, 1997 through September 30, 1997, in the evaluation of Yucca Mountain as a potential site for the geologic disposal of spent nuclear fuel and high-level radioactive wastes. The progress report also cites technical reports and research products that provide the detailed information on these activities. Chapter 2 outlines technical and regulatory issues that must be addressed by the Project and planned work toward achieving future objectives concerning the viability assessment, the environmental impact statement, the site recommendation, and the license application. Chapter 3 describes technical progress in preclosure radiological safety analysis, postclosure performance assessment, and performance confirmation activities. Chapter 4 describes various aspects of repository and waste package design and construction. It also discusses the Exploration Studies Facility cross drift. Chapter 5 describes site characterization activities, and Chapter 6 contains a complete list of references

  12. Evaluation of geometric features as biomarkers of diabetic retinopathy for characterizing the retinal vascular changes during the progression of diabetes

    OpenAIRE

    Leontidis, Georgios; Al-Diri, Bashir; Wigdahl, Jeffrey; Hunter, Andrew

    2015-01-01

    Diabetic retinopathy (DR) has been widely studied and characterized. However, until now, it is unclear how different features, extracted from the retinal vasculature, can be associated with the progression of diabetes and therefore become biomarkers of DR. In this study, a comprehensive analysis is presented, in which four groups were created, using eighty fundus images from twenty patients, who have progressed to DR and they had no history of any other diseases (e.g. hypertension or glaucoma...

  13. Progress with vegetation studies in South Africa

    Directory of Open Access Journals (Sweden)

    J. C. Scheepers

    1983-12-01

    Full Text Available Vegetation studies at various levels of detail and using various methods are briefly reviewed. The approach and procedures of the Zurich-Montpellier school of phytosociology as a standard methodology for regional studies has become increasingly recognized. Progress has been made in regional studies in the fynbos and woodland biomes. but grassland, forest and karoo vegetation have been much neglected. There have also been marked increases in activity over a wide range of additional vegetation studies including new fields of research, particularly ecosystem studies. However, there are still vast gaps in our knowledge of the basic vegetationa! resources of the country. A systematic regional-study programme is being launched to remedy these deficiencies in fundamental knowledge.

  14. Progress in glial cell studies in some laboratories in China

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Glial cells in the central nervous system(CNS) consist of a heterogeneous population of cell types,each characterized by distinct morphological features,physiological properties,and specific markers.In contrast to the previous view that glial cells were passive elements in the brain,accumulating evidence suggests that glial cells are active participants in various brain functions and brain disorders.This review summarizes recent progress of glial cell studies from several groups in China,ranging from studies about the mechanisms of neuron-glia crosstalking to investigations on the roles of glial cells in various CNS disorders.

  15. Coordination: southeast continental shelf studies. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Menzel, D.W.

    1980-03-01

    The GABEX I experiment is designed to provide synoptic coverage of a series of Gulf Stream wave-like disturbances, the effect of these on the circulation of the entire shelf, and on biological and chemical processes. This study was initiated in February 1980 when current meter arrays were deployed. These meters will be removed in July 1980. In April three ships will simultaneously study the effects of Gulf Stream disturbances on the hydrography, chemistry, and biology of the shelf. One vessel will track a specific wave-like disturbance and provide synoptic coverage of the shelf area. The second vessel will determine the effect of shelf break processes on adjacent shelf water; and the third will study trace metal distributions in and outside of disturbances. Research progress is reported in continental shelf studies, nearshore and estuarine studies (diffusion of freshwater out of nearshore zone), tidal currents and material transport, and mixing of inlet plumes.

  16. Site characterization progress report: Yucca Mountain, Nevada, April 1, 1993--September 30, 1993, No. 9

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-02-01

    In accordance with requirements of Section 113(b)(3) of the Nuclear Waste Policy Act of 1982, as amended, and 10 CFR 60.18(g), the U.S. Department of Energy has prepared this report on the progress of site characterization activities at Yucca Mountain, Nevada, for the period April 1, 1993, through September 30, 1993. This report is the ninth in a series issued at intervals of approximately six months during site characterization of Yucca Mountain as a possible site for a geologic repository for the permanent disposal of high-level radioactive waste. Also included in this report are activities such as public outreach and international programs that are not formally part of the site characterization process. Information on these activities is provided to report on all aspects of the Yucca Mountain studies.

  17. Site characterization progress report: Yucca Mountain, Nevada, April 1, 1993--September 30, 1993, No. 9

    International Nuclear Information System (INIS)

    In accordance with requirements of Section 113(b)(3) of the Nuclear Waste Policy Act of 1982, as amended, and 10 CFR 60.18(g), the U.S. Department of Energy has prepared this report on the progress of site characterization activities at Yucca Mountain, Nevada, for the period April 1, 1993, through September 30, 1993. This report is the ninth in a series issued at intervals of approximately six months during site characterization of Yucca Mountain as a possible site for a geologic repository for the permanent disposal of high-level radioactive waste. Also included in this report are activities such as public outreach and international programs that are not formally part of the site characterization process. Information on these activities is provided to report on all aspects of the Yucca Mountain studies

  18. Site characterization progress report: Yucca Mountain, Nevada, October 1, 1992--March 31, 1993, No. 8

    International Nuclear Information System (INIS)

    In accordance with requirements of Section 113(b)(3) of the Nuclear Waste Policy Act of 1982, as amended, and 10 CFR 60.18(g), the US Department of Energy has prepared this report on the progress of site characterization activities at Yucca Mountain, Nevada, for the period October 1, 1992, through March 31, 1993. This report is the eighth in a series issued at intervals of approximately six months during site characterization of Yucca Mountain as a possible site for a geologic repository for the permanent disposal of high-level radioactive waste. Also included in this report are activities such as public outreach and international programs that are not formally part of the site characterization process. Information on these activities is provided to report on all aspects of the Yucca Mountain studies

  19. Site characterization progress report: Yucca Mountain, Nevada, October 1, 1992--March 31, 1993, No. 8

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-08-01

    In accordance with requirements of Section 113(b)(3) of the Nuclear Waste Policy Act of 1982, as amended, and 10 CFR 60.18(g), the US Department of Energy has prepared this report on the progress of site characterization activities at Yucca Mountain, Nevada, for the period October 1, 1992, through March 31, 1993. This report is the eighth in a series issued at intervals of approximately six months during site characterization of Yucca Mountain as a possible site for a geologic repository for the permanent disposal of high-level radioactive waste. Also included in this report are activities such as public outreach and international programs that are not formally part of the site characterization process. Information on these activities is provided to report on all aspects of the Yucca Mountain studies.

  20. Progress in nanoparticles characterization:Sizing and zeta potential measurement

    Institute of Scientific and Technical Information of China (English)

    Renliang Xu

    2008-01-01

    Characterization of various nanoparticles is on the center stage in nanotechnology development. The subjects for nanoparticles characterization are focused on particle size and particle surface charge determinations. This article summarizes the latest development in particle size analysis using dynamic light scattering and surface charge determination using electrophoretic light scattering for nano- or even sub-nanoparticles in concentrated suspensions.

  1. Study of heavy flavored particles. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    1991-12-31

    This report discusses progress on the following topics: time-of- flight system; charmed baryon production and decays; D decays to baryons; measurement of sigma plus particles magnetic moments; and strong interaction coupling. (LSP)

  2. Radioactivity studies. Progress report. Volume II

    International Nuclear Information System (INIS)

    The metabolism of 243244Cm in nine adult female baboons following intravenous injection was studied. Curium-243,244 was administered as a single injection of curium citrate in dosages of 0.053 to 0.220 μCi/kg. The behavior of 243244Cm at these low dosages was quantitated by external whole-body and partial-body counting, bioassay of blood, urine and feces samples, liver biopsies, and post-mortem tissues analysis. Curium-243,244 rapidly passed from the blood to other tissues. At 1 and 24 h after injection, the amounts circulating were 10% and 1%, respectively. At 24 h after injection 70% of the 243244Cm was located within soft tissues, probably associated with extracellular fluid; the liver alone contained 32% of the injected activity. During the first weeks the content of 243244Cm in soft tissues decreased sharply. As time progressed, significant deposition was noted in the liver and the skeleton. Approximately 20% of the injected activity was in the liver at 1 month with a 40 day half-time. The skeleton reached a maximum burden of 57% by 100 days; the half-time observed in bone was 4 to 16 y. During the first 24 h, 10% of the injected activity appeared in the urine decreasing to 0.1%/day at 30 days and 0.01%/day at 200 days. Fecal excretion increased reaching a maximum level at four weeks. The amount of 243244Cm excreted in the feces during the initial 4 to 5 months (approx. 20%) and the rate of elimination in the feces after the first month paralleled the retention in the liver indicating an hepatic-biliary-fecal pathway. A model illustrating the interaction of seven internal compartments with respect to the translocation kinetics of 243244Cm was derived based upon this data. Solutions of the model were derived for two specific time-related exposures

  3. Progress in structural studies of telomerase

    OpenAIRE

    Miracco, Edward J.; Jiang, Jiansen; Cash, Darian; Feigon, Juli

    2014-01-01

    Telomerase is the ribonucleoprotein (RNP) reverse transcriptase responsible for synthesizing the 3′ ends of linear chromosomes. It plays critical roles in tumorigenesis, cellular aging, and stem cell renewal. The past two years have seen exciting progress in determining telomerase holoenzyme architecture and the structural basis of telomerase activity. Notably, the first electron microscopy structures of telomerase were reported, of the Tetrahymena thermophila telomerase holoenzyme and a huma...

  4. Progress in the studies of photoelectrochemical sensors

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Photoelectrochemical sensor is a new kind of developing analytical device based on the photoelectrochemical properties of materials.Because of its remarkable sensitivity,inherent miniaturization,portability and easy integration,photoelectrochemical analysis is becoming a promising analytical technique.This review focuses on the basic principles,classification,characteristics,and research progress of photoelectrochemical sensors with 94 references.The prospect of the development of photoelectrochemical sensors is also evaluated and discussed.

  5. Distinct lncRNA transcriptional fingerprints characterize progressive stages of multiple myeloma.

    Science.gov (United States)

    Ronchetti, Domenica; Agnelli, Luca; Taiana, Elisa; Galletti, Serena; Manzoni, Martina; Todoerti, Katia; Musto, Pellegrino; Strozzi, Francesco; Neri, Antonino

    2016-03-22

    Although many efforts have recently contributed to improve our knowledge of molecular pathogenesis of multiple myeloma (MM), the role and significance of long non-coding RNAs (lncRNAs) in plasma cells (PC) malignancies remains virtually absent. To this aim, we developed a custom annotation pipeline of microarray data investigating lncRNA expression in PCs from 20 monoclonal gammopathies of undetermined significance, 33 smoldering MM, 170 MM, and 36 extra-medullary MMs/plasma cell leukemia patients, and 9 healthy donors. Our study identified 31 lncRNAs deregulated in tumor samples compared to normal controls; among these, the upregulation of MALAT1 appeared associated in MM patients with molecular pathways involving cell cycle regulation, p53-mediated DNA damage response, and mRNA maturation processes. Furthermore, we found 21 lncRNAs whose expression were progressively deregulated trough the more aggressive stages of PC dyscrasia, suggesting a possible role in the progression of the disease. Finally, in the context of molecular heterogeneity of MM, we identified a transcriptional fingerprint in hyperdiploid patients, characterized by the upregulation of lncRNAs/pseudogenes related to ribosomal protein genes, known to be upregulated in this molecular group. Overall, the data provides an important resource for future studies on the functions of lncRNAs in the pathology. PMID:26895470

  6. Distinct lncRNA transcriptional fingerprints characterize progressive stages of multiple myeloma

    Science.gov (United States)

    Taiana, Elisa; Galletti, Serena; Manzoni, Martina; Todoerti, Katia; Musto, Pellegrino; Strozzi, Francesco; Neri, Antonino

    2016-01-01

    Although many efforts have recently contributed to improve our knowledge of molecular pathogenesis of multiple myeloma (MM), the role and significance of long non-coding RNAs (lncRNAs) in plasma cells (PC) malignancies remains virtually absent. To this aim, we developed a custom annotation pipeline of microarray data investigating lncRNA expression in PCs from 20 monoclonal gammopathies of undetermined significance, 33 smoldering MM, 170 MM, and 36 extra-medullary MMs/plasma cell leukemia patients, and 9 healthy donors. Our study identified 31 lncRNAs deregulated in tumor samples compared to normal controls; among these, the upregulation of MALAT1 appeared associated in MM patients with molecular pathways involving cell cycle regulation, p53-mediated DNA damage response, and mRNA maturation processes. Furthermore, we found 21 lncRNAs whose expression were progressively deregulated trough the more aggressive stages of PC dyscrasia, suggesting a possible role in the progression of the disease. Finally, in the context of molecular heterogeneity of MM, we identified a transcriptional fingerprint in hyperdiploid patients, characterized by the upregulation of lncRNAs/pseudogenes related to ribosomal protein genes, known to be upregulated in this molecular group. Overall, the data provides an important resource for future studies on the functions of lncRNAs in the pathology. PMID:26895470

  7. Stratigraphic characterization of the Anthropocene: a progress report

    Science.gov (United States)

    Zalasiewicz, Jan

    2014-05-01

    Rapid and large-scale anthropogenic changes have led to the concept that we are now living through the beginning of the Anthropocene Epoch - an interval of geological time dominated by human influence. The term was proposed little more than a decade ago by Paul Crutzen, the Nobel Prize-winning atmospheric chemist, and has since been widely used - and sharply debated. Its stratigraphic analysis needs considering the various kinds of historical and environmental change in terms of geological - or more precisely stratigraphic - change. Lithostratigraphic change, for instance, is strikingly represented by the spread of the 'urban stratum', the refashioning of sand, clay and limestone into our buildings, foundations and transport systems. Biostratigraphic changes include the ongoing mass extinction event and the effect of invasive species (while deep human-made bioturbation is a novel aspect the fossil record). Chemostratigraphic changes include the reshaping of the Earth's natural carbon, phosphorus and nitrogen cycles. As regards the potential formalizing of the Anthropocene, one question to be pursued relates to the chronostratigraphic definition of the phenomena involved: that is, given that many of these transformations are diachronous on human timescales, can an Anthropocene Series, with a synchronous time boundary, be characterized and mapped across the Earth's surface? Efforts to answer this question (Williams et al. 2011; Waters et al., in press) should help in the understanding of the Anthropocene within its geological context, and also in exploring the stratigraphic relation between time and rock generally at very fine stratigraphic timescales. Waters, C.W., Zalasiewicz, J.A., Williams, M., Ellis, M. & Snelling, A. In press. A Stratigraphical Basis for the Anthropocene. Geological Society of London, Special Publication. Williams, M., Zalasiewicz, J., Haywood, A. & Ellis M. (eds) 2011. The Anthropocene: a new epoch of geological time? Philosophical

  8. Site characterization progress report: Yucca Mountain, Nevada, April 1, 1992--September 30, 1992, Number 7

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-12-01

    In accordance with section 113(b)(3) of the Nuclear Waste Policy Act of 1982, as amended (NWPA), the Department has prepared the seventh in a series of reports on the progress of site characterization at the Yucca Mountain candidate site. The Civilian Radioactive Waste Management Program made significant progress during the reporting period at the Yucca Mountain Site Characterization Project. Several important advances were made in the surface-based testing program including: initiation of borehole drilling utilizing the new, state-of-the-art LM-300 drill rig which employs dry drilling and coring techniques; neutron access borehole drilling to evaluate infiltration processes; excavations to aid geologic mapping; and trenching in Midway Valley to study Quaternary faulting. A Floodplain Assessment and Statement of Findings was published in the Federal Register which concluded there would be no significant impact nor cumulative impacts on floodplains resulting from Exploratory Studies Facility activities. The National Academy of Sciences` National Research Council released its report entitled ``Ground Water at Yucca Mountain: How High Can It Rise?`` which concluded that none of the evidence cited as proof of groundwater upwelling in and around Yucca Mountain could be reasonably attributed to that process and that significant water table excursions to the repository design level are not shown by the geologic record. The June 29, 1992, earthquake near Yucca Mountain provided scientists with a wealth of information relevant to understanding the neotectonics of the area and the geometry of faults at depth. Early findings suggest that accelerations recorded were well within proposed design limits for the surface waste handling facilities.

  9. Site characterization progress report: Yucca Mountain, Nevada, April 1, 1992--September 30, 1992, Number 7

    International Nuclear Information System (INIS)

    In accordance with section 113(b)(3) of the Nuclear Waste Policy Act of 1982, as amended (NWPA), the Department has prepared the seventh in a series of reports on the progress of site characterization at the Yucca Mountain candidate site. The Civilian Radioactive Waste Management Program made significant progress during the reporting period at the Yucca Mountain Site Characterization Project. Several important advances were made in the surface-based testing program including: initiation of borehole drilling utilizing the new, state-of-the-art LM-300 drill rig which employs dry drilling and coring techniques; neutron access borehole drilling to evaluate infiltration processes; excavations to aid geologic mapping; and trenching in Midway Valley to study Quaternary faulting. A Floodplain Assessment and Statement of Findings was published in the Federal Register which concluded there would be no significant impact nor cumulative impacts on floodplains resulting from Exploratory Studies Facility activities. The National Academy of Sciences' National Research Council released its report entitled ''Ground Water at Yucca Mountain: How High Can It Rise?'' which concluded that none of the evidence cited as proof of groundwater upwelling in and around Yucca Mountain could be reasonably attributed to that process and that significant water table excursions to the repository design level are not shown by the geologic record. The June 29, 1992, earthquake near Yucca Mountain provided scientists with a wealth of information relevant to understanding the neotectonics of the area and the geometry of faults at depth. Early findings suggest that accelerations recorded were well within proposed design limits for the surface waste handling facilities

  10. Progress in the study of drug nanocrystals.

    Science.gov (United States)

    Shi, Jing; Guo, Fei; Zheng, Aiping; Zhang, Xiaoyan; Sun, Jianxu

    2015-12-01

    The poor water solubility of many candidate drugs remains a major obstacle to their development and clinical use, especially for oral drug delivery. Nanocrystal technology can improve the solubility and dissolution rates of many poorly water-soluble drugs very effectively, significantly improving their oral bioavailability and decreasing the food effect. For this reason, this technology is becoming a key area of drug delivery research. This review presents much of the recent progress in nanocrystal drug pharmaceuticals, including the characteristics, composition, preparation technology, and clinical applications of these drugs. Finally, the effect of nanocrystal technology on insoluble drugs is quantified and described. PMID:26817271

  11. Progresses in studies of nuclear actin

    Institute of Scientific and Technical Information of China (English)

    ZHU Xiaojuan; ZENG Xianlu; SONG Zhaoxia; HAO Shui

    2004-01-01

    Actin is a protein abundant in cells. Recently, it has been proved to be universally existent in the nuclei of many cell types. Actin and actin-binding proteins, as well as actin-related proteins, are necessary for the mediation of the conformation and function of nuclear actin, including the transformation of actin between unpolymerized and polymerized, chroinatin remodeling, regulation of gene expression and RNA processing as well as RNA transportation. In this paper, we summarized the progresses in the research of nu clear actin.

  12. GKI water quality studies. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Hutchinson, D L

    1980-01-01

    GKI water quality data collected in 1978 and early 1979 was evaluated with the objective of developing preliminary characterizations of native groundwater and retort water at Kamp Kerogen, Uintah County, Utah. Restrictive analytical definitions were developed to describe native groundwater and GKI retort water in an effort to eliminate from the sample population both groundwater samples affected by retorting and retort water samples diluted by groundwater. Native groundwater and retort water sample analyses were subjected to statistical manipulation and testing to summarize the data to determine the statistical validity of characterizations based on the data available, and to identify probable differences between groundwater and retort water based on available data. An evaluation of GKI water quality data related to developing characterizations of native groundwater and retort water at Kamp Kerogen was conducted. GKI retort water and the local native groundwater both appeared to be of very poor quality. Statistical testing indicated that the data available is generally insufficient for conclusive characterizations of native groundwater and retort water. Statistical testing indicated some probable significant differences between native groundwater and retort water that could be determined with available data. Certain parameters should be added to and others deleted from future laboratory analyses suites of water samples.

  13. Characterization of plant plasma membrane antigens: [Annual] progress report

    International Nuclear Information System (INIS)

    Protoplast plasma membranes were used to raise antibodies in mice to cell surface antigens. Monoclonal antibodies were selected from those produced and used for indirect immunofluorescence microscopic analysis of N. tabacum cells. In parallel studies cDNA expression libraries were prepared. (DT)

  14. Kodiak Island bald eagle migration and movements study: Progress report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this report is to update the progress of the bald eagle migration and movements study begun during July 1982. The study was initiated to: 1 determine...

  15. Kodiak Island bald eagle migration and movements study: Progress report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this report is to update the progress of the bald eagle migration and movements study begun during July 1982. The study was initiated to: (1)...

  16. Ramsay Hunt Syndrome : Clinical Characterization of Progressive Myoclonus Ataxia Caused by GOSR2 Mutation

    NARCIS (Netherlands)

    van Egmond, Martje E.; Verschuuren - Bemelmans, Cornelia; Nibbeling, Esther A.; Elting, Jan Willem J.; Sival, Deborah A.; Brouwer, Oebele F.; de Vries, Jeroen J.; Kremer, Hubertus P.; Sinke, Richard J.; Tijssen, Marina A.; de Koning, Tom J.

    2014-01-01

    BACKGROUND: Ramsay Hunt syndrome (progressive myoclonus ataxia) is a descriptive diagnosis characterized by myoclonus, ataxia, and infrequent seizures. Often the etiology cannot be determined. Recently, a mutation in the GOSR2 gene (c.430G>T, p.Gly144Trp) was reported in 6 patients with childhood-on

  17. A Contrastive Study of Progressive Aspect in English and Chinese

    Institute of Scientific and Technical Information of China (English)

    田中锋

    2015-01-01

    Aspect, which is different from tense, deals with the internal structure of an action and allows people to describe or understand how an event unfolds over time. This paper examines the similarities and differences between English and Chinese progressive aspect in terms of form, meaning and use. The main findings are that in the first place the progressive aspect in both English and Chinese expresses the same core meaning, which is to describe the incomplete or ongoing state of an event or action. Secondly, the progressive aspect in English must be realized by grammatical device with inflectional changes, whereas in Chinese, it can be realized without verbal inflections (only with aspect markers). Thirdly, there exist differences between the English and Chinese progressive aspect in some specific usages. This contrastive study aims to deepen the understanding of the two languages, and provide practical and effective pedagogical suggestions for Chinese learners of English studying the progressive aspect.

  18. Site characterization progress report: Yucca Mountain, Nevada, April 1, 1991--September 30, 1991, Number 5

    International Nuclear Information System (INIS)

    The Site Characterization Progress Report of Yucca Mountain (PR) presents brief summaries of the status of site characterization activities and cites the technical reports and research products that provide more detailed information on the activities. The report provides highlights of work started during the reporting period, work in progress, and work completed and documented during the reporting period. In addition, the report is the vehicle for the discussion of changes to the DOE's site characterization program resulting from ongoing collection and evaluation of site information; the development of repository and waste-package designs; the results of performance assessments; and any changes that occur in response to external comments. Information covered includes geochemistry, hydrology, geology, climate, and radiation dose estimate calculations

  19. Progressive multifocal leuko-encephalopathy studied by magnetization transfer imaging

    International Nuclear Information System (INIS)

    Purpose: magnetization transfer imaging (MT) has bees used to study the degree of demyelination in progressive multifocal leuko-encephalopathy (PML). Material and method: two groups were studied: a group of 10 HIV + patients with clinical, MR features, biological and/or biopsy proven PLM, and a group of 11 normal volunteers with matched age. MT ratio (MTR) were obtained from the center of the PLM lesions and 11 areas of normal appearing white matter (NAWM) in the control group. Results: the mean MTR of NAWM in the control group was 46.6% (SD = 2,3). PLM lesions demonstrated a strong and significant (p = 0) decreased of the MTR with mean MTR value of 22.4% (SD = 2,3). Conclusion: MT characterized the demyelinating process in PLM, and can be to used to improve diagnosis. Furthermore, MT allowed a quantification of the degree of the demyelination which can be helpful in other demyelinating process of CNS such multiple sclerosis. (authors)

  20. Studies in genetic discrimination. Final progress report

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    We have screened 1006 respondents in a study of genetic discrimination. Analysis of these responses has produced evidence of the range of institutions engaged in genetic discrimination and demonstrates the impact of this discrimination on the respondents to the study. We have found that both ignorance and policy underlie genetic discrimination and that anti-discrimination laws are being violated.

  1. Coordination: Southeast Continental Shelf studies. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Menzel, D.W.

    1981-02-01

    An overview of the Oceanograhic Program of Skidaway Institute of Oceanograhy is presented. Included are the current five year plan for studies of the Southeast Continental Shelf, a summary of research accomplishments, proposed research for 1981-1982, current status of the Savannah Navigational Light Tower, and a list of publications. (ACR)

  2. ICPP water inventory study progress report

    International Nuclear Information System (INIS)

    Recent data from the Idaho Chemical Processing Plant (ICPP) indicate that water is entering the sumps located in the bottom of Tank Firm Vaults in quantities that exceed expected levels. In addition, perched water body(s) exist beneath the northern portion of the ICPP. Questions have been raised concerning the origin of water entering the Tank Farm sumps and the recharge sources for the perched water bodies. Therefore, in an effort to determine the source of water, a project has been initiated to identify the source of water for Tank Farm sumps and the perched water bodies. In addition, an accurate water balance for the ICPP will be developed. The purpose of this report is to present the specific results and conclusions for the ICPP water balance portion of the study. In addition, the status of the other activities being conducted as part of study, along with the associated action plans, is provided

  3. ICPP water inventory study progress report

    Energy Technology Data Exchange (ETDEWEB)

    Richards, B.T.

    1993-05-01

    Recent data from the Idaho Chemical Processing Plant (ICPP) indicate that water is entering the sumps located in the bottom of Tank Firm Vaults in quantities that exceed expected levels. In addition, perched water body(s) exist beneath the northern portion of the ICPP. Questions have been raised concerning the origin of water entering the Tank Farm sumps and the recharge sources for the perched water bodies. Therefore, in an effort to determine the source of water, a project has been initiated to identify the source of water for Tank Farm sumps and the perched water bodies. In addition, an accurate water balance for the ICPP will be developed. The purpose of this report is to present the specific results and conclusions for the ICPP water balance portion of the study. In addition, the status of the other activities being conducted as part of study, along with the associated action plans, is provided.

  4. Progress on HTR application's study in Indonesia

    International Nuclear Information System (INIS)

    Study on the application of HTRs for the enhanced oil recovery in the Duri oil field (Sumatra, Indonesia) was performed in 1986/1987. The economic and technological advantages over crude burning option were identified. Crude oil prices, HTR capital costs, discout rates, company's income structure represented dominant parameters. Further sensitivity calculations on important economic parameters were obtained to reflect the condition of 1988. This nuclear option was also incorporated in the energy planning study for the whole Indonesia using the MARKAL model, and resulted the conditions of its applicability. The scenarios chosen in this MARKAL study were high and low GDP growth rate, whereas the criteria chosen were the minimum cost with and without a predetermined policy of reduced domestic use of oil. In the high scenario the HTRs as well as the natural gas options could not compete against the low cost boilers with crude-oil fuel. But in the case of reduced domestic oil use the HTRs came out to supplement the crude-burning boilers starting in the sixth five year plan (1994 - 1999), even earlier than the natural gas option. The authors further discuss the industrial environment, in relation with the regional development, the possible local participation, as well as the plan to materialize the merits of this novel application. (author)

  5. Progress report on nuclear spectroscopic studies

    International Nuclear Information System (INIS)

    The Nuclear Physics group at the University of Tennessee, Knoxville (UTK) is involved in several aspects of heavy-ion physics including both nuclear structure and reaction mechanisms. While the main emphasis is on experimental problems, the authors have maintained a strong collaboration with several theorists in order to best pursue the physics of their measurements. During the last year they have had several experiments at the ATLAS at Argonne National Laboratory, the GAMMASPHERE at the LBL 88 Cyclotron, and with the NORDBALL at the Niels Bohr Institute Tandem. Also, they continue to be very active in the WA93/98 collaboration studying ultra-relativistic heavy ion physics utilizing the SPS accelerator at CERN in Geneva, Switzerland and in the PHENIX Collaboration at the RHIC accelerator under construction at Brookhaven National Laboratory. During the last year their experimental work has been in three broad areas: (1) the structure of nuclei at high angular momentum, (2) the structure of nuclei far from stability, and (3) ultra-relativistic heavy-ion physics. The results of studies in these particular areas are described in this document. These studies concentrate on the structure of nuclear matter in extreme conditions of rotational motion, imbalance of neutrons and protons, or very high temperature and density. Another area of research is heavy-ion-induced transfer reactions, which utilize the transfer of nucleons to states with high angular momentum to learn about their structure and to understand the transfer of particles, energy, and angular momentum in collisions between heavy ions

  6. Progress report on nuclear spectroscopic studies

    Energy Technology Data Exchange (ETDEWEB)

    Bingham, C.R.; Riedinger, L.L.; Sorensen, S.P.

    1996-01-16

    The experimental program in nuclear physics at the University of Tennessee, Knoxville, is led by Professors Carrol Bingham, Lee Riedinger, and Soren Sorenseni who respectively lead the studies of the exotic decay modes of nuclei far from stability, the program of high-spin research, and our effort in relativistic heavy-ion physics. Over the years, this broad program of research has been successful partially because of the shared University resources applied to this group effort. The proximity of the Oak Ridge National Laboratory has allowed us to build extremely strong programs of joint research, and in addition to play an important leadership role in the Joint Institute for Heavy Ion Research (JIHIR). Our experimental program is also very closely linked with those at other national laboratories: Argonne (collaborations involving the Fragment Mass Analyzer (FMA) and {gamma}-ray arrays), Brookhaven (the RHIC and Phenix projects), and Berkeley (GAMMASPHERE). We have worked closely with a variety of university groups in the last three years, especially those in the UNISOR and now UNIRIB collaborations. And, in all aspects of our program, we have maintained close collaborations with theorists, both to inspire the most exciting experiments to perform and to extract the pertinent physics from the results. The specific areas discussed in this report are: properties of high-spin states; study of low-energy levels of nuclei far from stability; and high energy heavy-ion physics.

  7. Progress report on nuclear spectroscopic studies

    International Nuclear Information System (INIS)

    The experimental program in nuclear physics at the University of Tennessee, Knoxville, is led by Professors Carrol Bingham, Lee Riedinger, and Soren Sorenseni who respectively lead the studies of the exotic decay modes of nuclei far from stability, the program of high-spin research, and our effort in relativistic heavy-ion physics. Over the years, this broad program of research has been successful partially because of the shared University resources applied to this group effort. The proximity of the Oak Ridge National Laboratory has allowed us to build extremely strong programs of joint research, and in addition to play an important leadership role in the Joint Institute for Heavy Ion Research (JIHIR). Our experimental program is also very closely linked with those at other national laboratories: Argonne (collaborations involving the Fragment Mass Analyzer (FMA) and γ-ray arrays), Brookhaven (the RHIC and Phenix projects), and Berkeley (GAMMASPHERE). We have worked closely with a variety of university groups in the last three years, especially those in the UNISOR and now UNIRIB collaborations. And, in all aspects of our program, we have maintained close collaborations with theorists, both to inspire the most exciting experiments to perform and to extract the pertinent physics from the results. The specific areas discussed in this report are: properties of high-spin states; study of low-energy levels of nuclei far from stability; and high energy heavy-ion physics

  8. Progress in the study of tectophysicochemistry

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Tectophysicochemistry is a research area that deals with the interrelations between physical and chemical changes of crustal materials caused by tectonism. A given tectonic force may be resolved into two parts: homogeneous stress and differential stress. Homogeneous stress refers to isotopic pressure, which is superimposed on the original pressure and affects the equilibrium of various chemical reactions. It is also a factor that influences petrogenesis, metallogenesis and metamorphism. Differential stress is commonly produced when external forces act on a given solid body. It may cause deformation of crustal materials and generate various kinds of structural features. Tectophysicochemistry pays special attention to pressure, temperature and other physicochemical conditions produced or induced by tectonism and studies the influences of additional tectonic parameters on various chemical equilibria, so it gradually develops into an independent area of science.

  9. Studies in development immunogenetics. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Owen, R D

    1975-03-26

    This contract provides the research support for a group concerned with a relatively large range of problems. The integrating thread that runs through it is that of an interest in development and its genetic regulation, mainly in complex organisms and with an emphasis on the immune system as a model for developmental analysis and as a tool for following the development of other systems, especially the brain. It includes studies of biochemical genetics, primarily from a developmental viewpoint and with particular regard to defense mechanisms, and cellular aspects of the immune system. It extends into the area of cancer immunology and cell specificities as related to tumor systems, primarily from an immunogenetic viewpoint and with particular reference to leukemias in the mouse, and to disruptions of genetic control mechanisms in tumor development, especially as approached through the reappearance of fetal antigens associated with tumor development.

  10. Radioactivity studies. Progress report. Volume I

    International Nuclear Information System (INIS)

    A model was developed to be used to calculate the accumulation of uranium in the organs of the human body for different kinds of exposure. The proposed model divides the human body into compartments: red cell, short-term bone, long-term bone, kidney, and urine. The transfer rate between compartments is governed by 1st order kinetics. Transfer from plasma to the other compartments is instantaneous. Feedback from compartments to plasma is taken into account. The division of blood into plasma and red cell compartment is important to the calculations of uranium transport during the first few days after exposure. It was noted that uranium in bone has two different half-lives depending on the site of deposition, a short-term and a long-term bone component. An analytical solution to the model was proposed for any time-dependent exposure to uranium. This methodology is unique to this model and represents a significant change in analytical solutions. Specific analytical solutions for common cases of uranium exposure were derived. These include: single injection dose to the blood; exposure to background levels of natural uranium by ingestion; exposure through inhalation during working hours for uranium workers; single inhalation dose; constant inhalation exposure during a finite interval of time; and single ingestion dose. For model verification five baboons were injected intravenously with uranium nitrate and the partition of uranium between plasma and red cells was studied. The half-life in short-term bone was derived and the distribution in soft tissues four days after injection was studied: the kidney was the main organ for uranium deposition. The concentration in human skeleton was equal to 0.02 μg U/g ash. For this concentration in skeleton the gastrointestinal absorption factor was calculated as 23% and the daily excretion as 0.24 μg U/day

  11. Willamette oxygen supplementation studies. Annual progress report

    International Nuclear Information System (INIS)

    Hydropower development and operations in the Columbia River basin have caused the loss of 5 million to 11 million salmonids. An interim goal of the Northwest Power Planning Council is to reestablish these historical numbers by doubling the present runs from 2.5 million adult fish to 5.0 million adult fish. This increase in production will be accomplished through comprehensive management of both wild and hatchery fish, but artificial propagation will play a major role in the augmentation process. The current husbandry techniques in existing hatcheries require improvements that may include changes in rearing densities, addition of oxygen, removal of excess nitrogen, and improvement in raceway design. Emphasis will be placed on the ability to increase the number of fish released from hatcheries that survive to return as adults. Rearing density is one of the most important elements in fish culture. Fish culturists have attempted to rear fish in hatchery ponds at densities that most efficiently use the rearing space available. Such efficiency studies require a knowledge of cost of rearing and the return of adults to the fisheries and to the hatchery

  12. IAEA progress report II - Study of archeological objects using PIXE analytical technique

    International Nuclear Information System (INIS)

    This is the second IAEA progress report for the period 2006-2007 (CRP number F23023). After adopting the PIXE one-run measurement using the Al funny filter as X-ray absorber which was described in the first progress report, two studies on ceramics were undertaken in order to be characterized based on their chemical composition. The first one concerned the characterization of 38 sherds from the locality of Ch'him (south of Beirut) that could help for future studies on ceramic provenance. Those samples are considered as reference materials as they are coming from kiln and workshop of the excavated site. The second study will be detailed in the current report. It concerned excavated pottery from Beirut, suspected to belong to North-Syrian production. (author)

  13. Site characterization progress report: Yucca Mountain, Nevada. October 1, 1996--March 31, 1997

    International Nuclear Information System (INIS)

    The report is the sixteenth in a series issued approximately every six months to report progress and results of site characterization activities being conducted to evaluate Yucca Mountain as a possible geologic repository for the disposal of spent nuclear fuel and high-level radioactive waste. This report highlights work started, in progress, and completed during the reporting period. In addition, this report documents and discusses changes to the Office of Civilian Radioactive Waste Management (OCRWM) Site Characterization Program (Program) resulting from the ongoing collection and evaluation of site information, systems analyses, development of repository and waste package designs, and results of performance assessment activities. Details on the activities summarized can be found in the numerous technical reports cited throughout the progress report. Yucca Mountain Site Characterization Project (Project) activities this period focused on implementing the near-term objectives of the revised Program Plan issued last period. Near-term objectives of the revised Program Plan include updating the US Department of Energy's (DOE) repository siting guidelines to be consistent with a more focused performance-driven program; supporting an assessment in 1998 of the viability of continuing with actions leading to the licensing of a repository; and if the site is suitable, submittal of a Secretarial site recommendation to the President in 2001 and license application the US Nuclear Regulatory Commission (NRC) in 2002. During this reporting period, the Project developed and baselined its long-range plan in December 1996. That revision reflected the detailed fiscal year (FY) 1997 work scope and funding plan previously baselined at the end of FY 1996. Site characterization activities have been focused to answer the major open technical issues and to support the viability assessment

  14. Site characterization progress report: Yucca Mountain, Nevada. October 1, 1996--March 31, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    The report is the sixteenth in a series issued approximately every six months to report progress and results of site characterization activities being conducted to evaluate Yucca Mountain as a possible geologic repository for the disposal of spent nuclear fuel and high-level radioactive waste. This report highlights work started, in progress, and completed during the reporting period. In addition, this report documents and discusses changes to the Office of Civilian Radioactive Waste Management (OCRWM) Site Characterization Program (Program) resulting from the ongoing collection and evaluation of site information, systems analyses, development of repository and waste package designs, and results of performance assessment activities. Details on the activities summarized can be found in the numerous technical reports cited throughout the progress report. Yucca Mountain Site Characterization Project (Project) activities this period focused on implementing the near-term objectives of the revised Program Plan issued last period. Near-term objectives of the revised Program Plan include updating the US Department of Energy`s (DOE) repository siting guidelines to be consistent with a more focused performance-driven program; supporting an assessment in 1998 of the viability of continuing with actions leading to the licensing of a repository; and if the site is suitable, submittal of a Secretarial site recommendation to the President in 2001 and license application the US Nuclear Regulatory Commission (NRC) in 2002. During this reporting period, the Project developed and baselined its long-range plan in December 1996. That revision reflected the detailed fiscal year (FY) 1997 work scope and funding plan previously baselined at the end of FY 1996. Site characterization activities have been focused to answer the major open technical issues and to support the viability assessment.

  15. A Review on Progress in QSPR Studies for Surfactants

    OpenAIRE

    Zhengwu Wang; Xiaoyi Zhang; Jiwei Hu

    2010-01-01

    This paper presents a review on recent progress in quantitative structure-property relationship (QSPR) studies of surfactants and applications of various molecular descriptors. QSPR studies on critical micelle concentration (cmc) and surface tension (γ) of surfactants are introduced. Studies on charge distribution in ionic surfactants by quantum chemical calculations and its effects on the structures and properties of the colloids of surfactants are also reviewed. The trends of QSPR studies o...

  16. Progression of diabetic retinopathy: the Beijing Eye Study

    Institute of Scientific and Technical Information of China (English)

    TU Ying; XU Liang; WEI Wen-bin; WANG Shuang; WANG Ya-xing; Jost B Jonas

    2011-01-01

    Background Diabetic retinopathy (DR) has emerged as a leading cause of visual impairment and blindness in the working-aged population worldwide.This study aimed to assess frequency and associated factors of progression of DR in subjects with known diabetes in a population-based setting.Methods The Beijing Eye Study is a population based study performed in Greater Beijing in 2001 and 2006.The present investigation included all subjects with known diabetes mellitus in 2001,who participated in the follow-up examination in 2006.Fundus photographs were assessed.Results The study included 170 subjects; 51 (30%) subjects showed signs of DR in 2001 and were re-examined in 2006,36 (21.2%) subjects (18 subjects with DR present at baseline,18 subjects with newly diagnosed DR in 2006)showed a progression of DR during follow-up.Progression of DR was associated with rural region (odds ratio (OR):5.43,P=0.001) and self-reported arterial hypertension (OR:3.85,P=0.023).In the non-progressive subgroup,presence of DR was associated with different levels of education (<middle school,middle school,college or higher,OR:0.30,P=0.023),treatment modes of diabetes mellitus (OR:10.24,P=0.003) and cataract surgery (OR:9.14,P=0.007).Conclusions In a population-based setting in Greater Beijing,progression of DR occurred in 35% of subjects with pre-existing DR and overall in 21% of subjects with known diabetes within a 5-year period.Progression of DR was significantly associated with rural region and self-reported arterial hypertension.In the stable subjects,presence of DR was significantly associated with poor educational level,insulin treatment of diabetes and cataract surgery.

  17. On Studies of Moral Socialization of Students: Progress and Perplexities

    Science.gov (United States)

    Zhang, Renjie

    2008-01-01

    Moral socialization of students consists of five elements: process, subject, agent, content and pattern. This paper discusses the studies of the former three: their progress and perplexities, covering the following puzzles: "Why does the youth socialization take longer time?" "Are there any critical periods in student socialization?" "How do we…

  18. Site characterization progress report, Yucca Mountain, Nevada. Number 19, April 1, 1998 - September 30, 1998

    International Nuclear Information System (INIS)

    The nineteenth semiannual report of the Yucca Mountain Site Characterization Project (YMP) summarizes activities during the period from April 1, 1998, through September 30, 1998. Project activities are aimed at evaluating Yucca Mountain as a potential location for permanent geologic disposal of nuclear materials, as directed by the Nuclear Waste Policy Act of 1982, as amended (NWPA). The progress report documents activities this period that contribute to completing the Project's near-term programmatic and statutory objectives. These objectives include completing the Viability Assessment, the Environmental Impact Statement (EIS), a possible US Department of Energy (DOE) Secretarial Site Recommendation to the President, and, if the site is suitable, submittal of a license application to the US Nuclear Regulatory Commission (NRC). Project work this period continued to be concentrated in three integrated activities: site characterization, engineering design and construction, and performance assessment. Accomplishments this period and their relation to near-term objectives are briefly summarized

  19. Unified approach to characterization of collisions between reactive radical pairs in solution. Technical progress report

    International Nuclear Information System (INIS)

    Purpose of this program, initiated on March 15, 1982, is to study the interactions between organic free radicals .CH2X in aqueous and organic solvents, using four methods: (1) kinetic EPR, (2) Heisenberg exchange rate measurements by means of pulsed EPR, (3) CIDEP, and (4) CIDNP. Progress to date is reported. No data is given

  20. Joint inversion of geophysical data for site characterization and restoration monitoring. 1998 annual progress report

    International Nuclear Information System (INIS)

    'The purpose of this project is to develop a computer code for joint inversion of seismic and electrical data, to improve underground imaging for site characterization and remediation monitoring. The computer code developed in this project will invert geophysical data to obtain direct estimates of porosity and saturation underground, rather than inverting for seismic velocity and electrical resistivity or other geophysical properties. This is intended to be a significant improvement in the state-of-the-art of underground imaging, since interpretation of data collected at a contaminated site would become much less subjective. Potential users include DOE scientists and engineers responsible for characterizing contaminated sites and monitoring remediation of contaminated sites. In this three-year project, the authors use a multi-phase approach consisting of theoretical and numerical code development, laboratory investigations, testing on available laboratory and borehole geophysics data sets, and a controlled field experiment, to develop practical tools for joint electrical and seismic data interpretation. This report summarizes work after about 1.7 years of a 3-year project. Progress on laboratory measurements is described first, followed by progress on developing algorithms for the inversion code to relate geophysical data to porosity and saturation.'

  1. Physical-chemical studies of transuranium elements. Progress report, April 1, 1982-March 31, 1983

    International Nuclear Information System (INIS)

    Progress is reported on the following topics: electrochemical and spectroscopic studies of less-stable higher oxidation states of transuranium elements in complexing aqueous media; spectroscopic and electrochemical studies of selected lanthanides and actinides in molten dimethyl sulfone; spectroelectronchemical studies of the Ce(IV)/Ce(III) couple in aqueous carbonate solutions; characterization of actinide orthophosphates by Raman and absorption spectrophotometries and by x-ray diffraction; relativistic multiple scattering calculations on transuranium element compounds; Raman spectroscopic studies of natural minerals containing the uranyl ion; and solution calorimetry of californium metal

  2. Quantitative application study on the control system of contract progress

    International Nuclear Information System (INIS)

    Quantitative application study on the control system of contract progress, which is based on project management theory and PDCA cycle methods, provides a new way for the contract business management of enterprise, in line with the current situation and the nuclear power enterprise performance management needs. The concept of the system, system development, program design and development of ERP (VBA design) which come from the work experience summary of business managers are convenient and feasible in practical applications. By way of the applications in 2009, 2010, 2011 three-year overhaul contract management and continuous adjustment it has become an important business management tool, which not only effectively guaranteed the contract time and efficiency, but also combines the performance management and contract progress management. This study has provided useful reference for the enterprise management. (authors)

  3. Progress in Studies of Geomagnetic Navigation of Animals

    Institute of Scientific and Technical Information of China (English)

    Tian Lanxiang; Pan Yongxin; Lin Wei; Wang Yinan; Zhang Shuyi

    2005-01-01

    @@ The geomagnetic field may play a key role in orientation and navigation of many long-distance migratory animals. Taking homing and migrating birds as examples, this paper reviews recent progress in studies of geomagnetic "compass" of animals.Moreover, we propose to address two aspects in future geomagnetic orientation research: ( 1 ) what are the true components of the "map"? (2) What are the magneto-receptors and which brain areas acquire and process the geomagnetic field information ?

  4. Ventricular volume and dementia progression in the Cardiovascular Health Study

    OpenAIRE

    Carmichael, Owen T.; Kuller, L.H.; Lopez, O L.; Thompson, P.M.; Dutton, R A; Lu, A.; Lee, S. E.; Lee, J.Y.; Aizenstein, H.J.; Meltzer, C.C.; Liu, Y. X.; Toga, A.W.; Becker, J.T.

    2006-01-01

    Elevated cerebral ventricular volume may be associated with dementia risk and progression. A fully-automated technique that agreed highly with radiological readings was used to estimate lateral ventricle volume on MR scans done at baseline in 1997-99 of 377 subjects in the Cardiovascular Health Study (CHS) from the Pittsburgh Center. 327 subjects were normal or diagnosed with mild cognitive impairment (MCI) at baseline and were evaluated 4 years later. Baseline ventric...

  5. Site characterization progress report: Yucca Mountain, Nevada, April 1, 1990--September 30, 1990, Number 3; Nuclear Waste Policy Act (Section 113)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-03-01

    In accordance with the requirements of Section 113(b)(3) of the Nuclear Waste Policy Act of 1982 (NWPA), as amended, the US Department of Energy has prepared this report on the progress of site characterization activities at Yucca Mountain, Nevada, for the period April 1 through September 30, 1990. This report is the third of a series of reports that are issued at intervals of approximately six months during site characterization. The report covers a number of new initiatives to improve the effectiveness of the site characterization program and covers continued efforts related to preparatory activities, study plans, and performance assessment. 85 refs., 2 figs., 3 tabs.

  6. Characterization of Machine Variability and Progressive Heat Treatment in Selective Laser Melting of Inconel 718

    Science.gov (United States)

    Prater, T.; Tilson, W.; Jones, Z.

    2015-01-01

    The absence of an economy of scale in spaceflight hardware makes additive manufacturing an immensely attractive option for propulsion components. As additive manufacturing techniques are increasingly adopted by government and industry to produce propulsion hardware in human-rated systems, significant development efforts are needed to establish these methods as reliable alternatives to conventional subtractive manufacturing. One of the critical challenges facing powder bed fusion techniques in this application is variability between machines used to perform builds. Even with implementation of robust process controls, it is possible for two machines operating at identical parameters with equivalent base materials to produce specimens with slightly different material properties. The machine variability study presented here evaluates 60 specimens of identical geometry built using the same parameters. 30 samples were produced on machine 1 (M1) and the other 30 samples were built on machine 2 (M2). Each of the 30-sample sets were further subdivided into three subsets (with 10 specimens in each subset) to assess the effect of progressive heat treatment on machine variability. The three categories for post-processing were: stress relief, stress relief followed by hot isostatic press (HIP), and stress relief followed by HIP followed by heat treatment per AMS 5664. Each specimen (a round, smooth tensile) was mechanically tested per ASTM E8. Two formal statistical techniques, hypothesis testing for equivalency of means and one-way analysis of variance (ANOVA), were applied to characterize the impact of machine variability and heat treatment on six material properties: tensile stress, yield stress, modulus of elasticity, fracture elongation, and reduction of area. This work represents the type of development effort that is critical as NASA, academia, and the industrial base work collaboratively to establish a path to certification for additively manufactured parts. For future

  7. Estuarine Physical Processes Research: Some Recent Studies and Progress

    Science.gov (United States)

    Uncles, R. J.

    2002-12-01

    The literature on estuarine physical studies is vast, diverse and contains many valuable case studies in addition to pure, process-based research. This essay is an attempt to summarize both some of the more recent studies that have been undertaken during the last several years, as well as some of the trends in research direction and progress that they represent. The topics covered include field and theoretical studies on hydrodynamics, turbulence, salt and fine sediment transport and morphology. The development and ease-of-application of numerical and analytical models and technical software has been essential for much of the progress, allowing the interpretation of large amounts of data and assisting with the understanding of complex processes. The development of instrumentation has similarly been essential for much of the progress with field studies. From a process viewpoint, much more attention is now being given to interpreting intratidal behaviour, including the effects of tidal straining and suspended fine sediment on water column stratification, stability and turbulence generation and dissipation. Remote sensing from satellites and aircraft, together with fast sampling towed instruments and high frequency radar now provide unique, frequently high resolution views of spatial variability, including currents, frontal and plume phenomena, and tidal and wave-generated turbidity. Observations of fine sediment characteristics (floc size, aggregation mechanisms, organic coatings and settling velocity) are providing better parameterizations for sediment transport models. These models have enhanced our understanding both of the estuarine turbidity maximum and its relationship to fronts and intratidal hydrodynamic and sedimentological variability, as well as that of simple morphological features such as intertidal mudflats. Although few, interdisciplinary studies to examine the relationships between biology and estuarine morphology show that bivalve activity and the

  8. Recent progress in high-pressure studies on organic conductors

    Directory of Open Access Journals (Sweden)

    Syuma Yasuzuka and Keizo Murata

    2009-01-01

    Full Text Available Recent high-pressure studies of organic conductors and superconductors are reviewed. The discovery of the highest Tc superconductivity among organics under high pressure has triggered the further progress of the high-pressure research. Owing to this finding, various organic conductors with the strong electron correlation were investigated under high pressures. This review includes the pressure techniques using the cubic anvil apparatus, as well as high-pressure studies of the organic conductors up to 10 GPa showing extraordinary temperature and pressure dependent transport phenomena.

  9. Progress of confinement physics study in compact helical system

    International Nuclear Information System (INIS)

    Large progress in the confinement improvement study in CHS was made for the internal transport barrier (ITB) and H-mode discharges with the edge transport barrier (ETB). For ITB, precise measurement of ion temperature gradient profile and the direct measurement of turbulent particle flux were made. For ETB study, edge fluctuations were measured with four different diagnostics and it was confirmed that the turbulence was suppressed by the ETB formation. The poloidal flow was measured and the creation of the strong electric field was confirmed for the H-mode discharges. H-mode with a high plasma density was developed with the reheat mode operation technique. (author)

  10. Characterization of radioactive waste forms. Progress report for 1986 Volume 1

    International Nuclear Information System (INIS)

    The Council of Ministers of the European Communities adopted the third five-year EC programme of research on radioactive waste management and disposal in March 1985. It was recognized that the inevitable production of radioactive waste required perfecting and demonstrating systems for managing the waste produced by the nuclear industry, ensuring at the various stages the best possible protection of man and the environment. Task 3 of the programme 'evaluation of conditioned waste and qualification of engineered barriers' is subdivided into five sections. This book, in two volumes, is a compilation of reports on the progress achieved in four of the sections during 1986, the first year of the third programme. Volume 1 is concerned with Sections 1 and 5, 'Research on low -and medium- active waste' and 'Quality control methods'. Volume 2 covers Section 2 'HLW form characterization' and Section 3 'Other engineered barriers'. Section 4 'Development of standard test methods' is not included in this edition, as results from an interlaboratory round robin test now in progress will only be available for inclusion for the year 1988

  11. Characterization of radioactive waste forms. Progress report for 1986 Volume 2

    International Nuclear Information System (INIS)

    The Council of Ministers of the European Communities adopted the third five-year EC programme of research on radioactive waste management and disposal in March 1985. It was recognized that the inevitable production of radioactive waste required perfecting and demonstrating systems for managing the waste produced by the nuclear industry, ensuring at the various stages the best possible protection of man and the environment. Task 3 of the programme 'evaluation of conditioned waste and qualification of engineered barriers' is subdivided into five sections. This book, in two volumes, is a compilation of reports on the progress achieved in four of the sections during 1986, the first year of the third programme. Volume 1 is concerned with Sections 1 and 5, 'Research on low-and medium- active waste' and 'Quality control methods'. Volume 2 covers Section 2 'HLW form characterization' and Section 3 'Other engineered barriers' Section 4 'Development of standard test methods' is not included in this edition, as results from an interlaboratory round robin test now in progress will only be available for inclusion for the year 1988

  12. Progress in the synthesis and reactivity studies of metallabenzenes

    Institute of Scientific and Technical Information of China (English)

    HE Guomei; XIA Haiping; JIA Guocheng

    2004-01-01

    Metallabenzenes are metallacyclohexatriene complexes that are derived by replacement of one of the CH groups in benzene with a transition-metal fragment. Their synthesis and aromatic properties have recently attracted considerable attention. This paper summarizes the progress in the synthesis, aromatic property, and reactivity studies of metallabenzenes. We will describe the synthesis and reactivity of typical metallabenzenes with various metals (e.g. osmium, iridium, and ruthenium, etc.), the synthesis and structure of a recent reported example of metallanaphthalene and several rare examples of novel and stable metallabenzynes. Finally, the possible future developments in this field have also been suggested.

  13. Characterization of caries progression on dentin after irradiation with Nd:YAG laser by FTIR spectroscopy and fluorescence imaging

    Science.gov (United States)

    Ana, P. A.; Brito, A. M. M.; Zezell, D. M.; Lins, E. C. C. C.

    2015-06-01

    Considering the use of high intensity lasers for preventing dental caries, this blind in vitro study evaluated the compositional and fluorescence effects promoted by Nd:YAG laser (λ=1064 nm) when applied for prevention of progression of dentin caries, in association or not with topical application of acidulated phosphate fluoride (APF). Sixty bovine root dentin slabs were prepared and demineralized by 32h in order to create early caries lesions. After, the slabs were distributed into six experimental groups: G1- untreated and not submitted to a pH-cycling model; G2- untreated and submitted to a pH-cycling model; G3- acidulated phosphate fluoride application (APF); G4- Nd:YAG irradiation (84.9 J/cm2, 60 mJ/pulse); G5- treated with Nd:YAG+APF; G6- treated with APF+Nd:YAG. After treatments, the samples of groups G2 to G6 were submitted to a 4-day pH-cycling model in order to simulate the progression of early caries lesions. All samples were characterized by the micro-attenuated total reflection technique of Fourier transformed infrared spectroscopy (μATR-FTIR), using a diamond crystal, and by a fluorescence imaging system (FIS), in which it was used an illuminating system at λ= 405±30 nm. Demineralization promoted reduction in carbonate and phosphate contents, exposing the organic matter; as well, it was observed a significant reduction of fluorescence intensity. Nd:YAG laser promoted additional chemical changes, and increased the fluorescence intensity even with the development of caries lesions. It was concluded that the compositional changes promoted by Nd:YAG, when associated to APF, are responsible for the reduction of demineralization progression observed on root dentin.

  14. Study and Characterization of Expansive Cement

    Directory of Open Access Journals (Sweden)

    Hugo Guerra Menéndez

    2011-10-01

    Full Text Available The objective of this study is to characterize commercial expansive cement for subsequent development of national formulation, with consequent economic effect and independence of the international market. On the other hand the results contribute to the development of scientific and technological potential. Expansive cement is a product that enables non-explosive demolition, rock and concrete demolition. To characterize the composition of these products, techniques used infrared spectroscopy with Fourier Transforms and Scanning Electron Microscopy.

  15. Study and Characterization of Expansive Cement

    OpenAIRE

    Hugo Guerra Menéndez; Eduardo Peón Avés; Julio E. Lanza Rodríguez

    2011-01-01

    The objective of this study is to characterize commercial expansive cement for subsequent development of national formulation, with consequent economic effect and independence of the international market. On the other hand the results contribute to the development of scientific and technological potential. Expansive cement is a product that enables non-explosive demolition, rock and concrete demolition. To characterize the composition of these products, techniques used infrared spectroscopy w...

  16. Progress on alternative method of the on-orbit RVS characterization for MODIS reflective solar bands

    Science.gov (United States)

    Chen, H.; Xiong, X.; Angal, A.; Geng, X.; Wu, A.

    2014-09-01

    MODIS Reflective Solar Bands (RSB) are calibrated on-orbit using its onboard calibrators, including a Solar Diffuser (SD), a Solar Diffuser Stability Monitor (SDSM), and a Spectroradiometric Calibration Assembly (SRCA). A Space View (SV) port is used to provide a background reference, and also facilitate near monthly lunar observations via a spacecraft roll. In every scan, the earth's surface, SV and onboard calibrators are viewed via a two sided scan mirror, whose reflectance depends on the angles of the incidence (AOI) as well as the wavelength of the incident light. Response versus Scan angle (RVS) is defined as a dependence function of the scan mirror's reflectance over AOI. An initial RVS for each RSB was measured prelaunch for both Terra and Aqua MODIS. Algorithms have been developed to track the on-orbit RVS variation using the measurements from the onboard calibrators, supplemented with the Earth View (EV) response from pseudo-invariant desert targets obtained at different AOI. The current approach, as implemented in Collection 6 (C6), uses EV responses from the Libyan desert sites to track the on-orbit RVS change. It strongly depends on the long-term temporal stability of the desert sites. As an effort to validate and, if necessary, to improve MODIS RSB RVS characterization for future applications, the MODIS Characterization Support Team (MCST) has developed and tested an alternative approach to monitor the on-orbit RVS change, using a response from a single desert site. The purpose of using data from one site is to avoid the impact of possible differences in the long-term temporal stability among multiple sites on the calculation of the on-orbit RVS. This paper updates recent progress in the formulation of the alternative RVS approach. Comprehensive comparisons were also performed with current C6 RVS results for both Terra and Aqua MODIS. Results demonstrate that this alternative method provides a supplemental means to track the on-orbit RVS for MODIS RSB.

  17. Site characterization progress report: Yucca Mountain, Nevada, October 1, 1993--March 31, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-10-01

    This report is the tenth in a series issued at intervals of approximately six months during site characterization of Yucca Mountain as a possible site for a geologic repository for the permanent disposal of spent nuclear fuel and high-level radioactive waste. Also included in this report are descriptions of activities such as public outreach and international programs that are not formally part of the site characterization process. Information on these activities is provided to report on all aspects of the Yucca Mountain studies. The Executive Summary is intended to provide a summary of major decisions, activities, accomplishments, and issues of interest during the reporting period. Chapter 1, Introduction, provides background information to assist the reader in understanding the current status of the program. Chapter 2 provides specific detailed discussions of activities conducted during the current reporting period and has two major divisions. Section 2.1, Preparatory Activities, provides information on select preparatory activities necessary to conduct site characterization and design activities. Sections 2.2 through 2.8 provide specific details on studies and activities conducted during the reporting period and follow the original structure of the Department`s 1988 Site Characterization Plan. Chapter 3 contains the current summary schedule, while Chapter 4 provides a description of the program outreach, including activities during the reporting period, in both the international program and public outreach. Chapter 5 presents an epilogue of significant events that occurred after the end of the reporting period.

  18. Site characterization progress report: Yucca Mountain, Nevada, October 1, 1993--March 31, 1994

    International Nuclear Information System (INIS)

    This report is the tenth in a series issued at intervals of approximately six months during site characterization of Yucca Mountain as a possible site for a geologic repository for the permanent disposal of spent nuclear fuel and high-level radioactive waste. Also included in this report are descriptions of activities such as public outreach and international programs that are not formally part of the site characterization process. Information on these activities is provided to report on all aspects of the Yucca Mountain studies. The Executive Summary is intended to provide a summary of major decisions, activities, accomplishments, and issues of interest during the reporting period. Chapter 1, Introduction, provides background information to assist the reader in understanding the current status of the program. Chapter 2 provides specific detailed discussions of activities conducted during the current reporting period and has two major divisions. Section 2.1, Preparatory Activities, provides information on select preparatory activities necessary to conduct site characterization and design activities. Sections 2.2 through 2.8 provide specific details on studies and activities conducted during the reporting period and follow the original structure of the Department's 1988 Site Characterization Plan. Chapter 3 contains the current summary schedule, while Chapter 4 provides a description of the program outreach, including activities during the reporting period, in both the international program and public outreach. Chapter 5 presents an epilogue of significant events that occurred after the end of the reporting period

  19. Progress in characterization of the Photomultiplier Tubes for XENON1T Dark Matter Experiment

    CERN Document Server

    Lyashenko, Alexey

    2015-01-01

    We report on the progress in characterization of the Hamamatsu model R11410-21 Photomultiplier tubes (PMTs) for XENON1T dark matter experiment. The absolute quantum efficiency (QE) of the PMT was measured at low temperatures down to -110 $^0$C (a typical the PMT operation temperature in liquid xenon detectors) in a spectral range from 154.5 nm to 400 nm. At -110 $^0$C the absolute QE increased by 10-15\\% at 175 nm compared to that measured at room temperature. A new low power consumption, low radioactivity voltage divider for the PMTs is being developed. The measurement results showed that the PMT with the current version of the divider demonstrated a linear response (within 5\\%) down to 5$\\cdot$10$^4$ photoelectrons at a rate of 200 Hz. The radioactive contamination induced by the PMT and the PMT voltage divider materials satisfies the requirements for XENON1T detector not to exceed a total radioactive contamination in the detector of 0.5 evts/year/1tonn. Most of the PMTs received from the manufacturer showe...

  20. Recent progress of MODIS solar diffuser on-orbit degradation characterization

    Science.gov (United States)

    Chen, H.; Wang, Z.; Sun, J.; Angal, A.; Xiong, X.

    2012-09-01

    An on-board Solar Diffuser (SD) is used for the MODIS reflective solar bands (RSB) calibration. Its on-orbit bidirectional reflectance factor (BRF) degradation is tracked using an on-board Solar Diffuser Stability Monitor (SDSM). The SDSM is a ratioing radiometer with nine detectors, covering wavelengths from 412 nm to 936 nm. During each scheduled SD calibration event, the SDSM makes alternate observations of the Sun and the sunlight reflected by the SD. To best match the SDSM detector signals from its Sun view and SD view, a fix attenuation screen is placed in its Sun view path. This paper provides a brief description of MODIS RSB on-orbit calibration and the use of its on-board SD and SDSM subsystem, including different approaches developed and used to track MODIS SD on-orbit degradation. It reports recent progress made to better characterize MODIS SD on-orbit degradation and to support MODIS Level 1B (L1B) calibration look-up table (LUT) updates for the upcoming collection 6 (C6) reprocessing. Results of both Terra and Aqua SD on-orbit degradation derived from newly improved SDSM Sun view screen vignetting function and response fitting strategy, and their impact on RSB calibration uncertainties are also presented.

  1. Progress in the Study of ALFALFA Galaxy Groups

    Science.gov (United States)

    Troischt, Parker; Nichols, Nathan

    2013-04-01

    The Undergraduate ALFALFA (Arecibo Legacy Fast ALFA) Team Groups Project is a collaborative undertaking of faculty and students at 11 institutions, aimed at investigating properties of galaxy groups surveyed by the ALFALFA blind HI survey. The survey covers 7,000 square degrees and is expected to include more than 30,000 extragalactic sources when completed. Here we present analysis of HI spectra taken at the National Astronomy and Ionosphere Center and report on progress made with developing analysis software tools as part of the UAT study. These tools will be implemented with follow up observations of targeted sources generated from the original blind survey. This work has been supported by NSF grants AST-0724918, AST-0725267 and AST-0725380.

  2. Progress in studies of solar eclipses recorded in early China

    Science.gov (United States)

    Liu, Ciyuan

    2003-03-01

    Systematic records of solar eclipses started from Chunqiu period. Such records are complete and regular from the Han to the Qing Dynasties. Before then, in the Xia, Shang and West Zhou Dynasties, records of solar eclipses were vague and scattered. Many people investigated them, but it is difficult to get final conclusions. With recent progress in astronomical computation and historic chronology, new achievements have been reached in studies of early solar eclipses. These records include "Sanmiao" and "Zhongkang" eclipses in the legends of the Xia Dynasty; "Three flames ate the Sun", "The sun and the moon were eclipsed" and "The sun was Zhi" on the oracle bones of the Shang Dynasty; "Tianda yi", "Double dawn" and "Poem eclipse" in the literature of West Zhou Dynasty.

  3. Recent progress of neuroimaging studies on sleeping brain

    International Nuclear Information System (INIS)

    Although sleep is a familiar phenomenon, its functions are yet to be elucidated. Understanding these functions of sleep is an important focus area in neuroscience. Electroencephalography (EEG) has been the predominantly used method in human sleep research but does not provide detailed spatial information about brain activation during sleep. To supplement the spatial information provided by this method, researchers have started using a combination of EEG and various advanced neuroimaging techniques that have been recently developed, including positron emission tomography (PET) and magnetic resonance imaging (MRI). In this paper, we will review the recent progress in sleep studies, especially studies that have used such advanced neuroimaging techniques. First, we will briefly introduce several neuroimaging techniques available for use in sleep studies. Next, we will review the spatiotemporal brain activation patterns during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep, the dynamics of functional connectivity during sleep, and the consolidation of learning and memory during sleep; studies on the neural correlates of dreams, which have not yet been identified, will also be discussed. Lastly, possible directions for future research in this area will be discussed. (author)

  4. Genome-wide association studies in asthma: progress and pitfalls

    Directory of Open Access Journals (Sweden)

    March ME

    2015-01-01

    Full Text Available Michael E March,1 Patrick MA Sleiman,1,2 Hakon Hakonarson1,2 1Center for Applied Genomics, Children's Hospital of Philadelphia Research Institute, 2Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Abstract: Genetic studies of asthma have revealed that there is considerable heritability to the phenotype. An extensive history of candidate-gene studies has identified a long list of genes associated with immune function that are potentially involved in asthma pathogenesis. However, many of the results of candidate-gene studies have failed to be replicated, leaving in question the true impact of the implicated biological pathways on asthma. With the advent of genome-wide association studies, geneticists are able to examine the association of hundreds of thousands of genetic markers with a phenotype, allowing the hypothesis-free identification of variants associated with disease. Many such studies examining asthma or related phenotypes have been published, and several themes have begun to emerge regarding the biological pathways underpinning asthma. The results of many genome-wide association studies have currently not been replicated, and the large sample sizes required for this experimental strategy invoke difficulties with sample stratification and phenotypic heterogeneity. Recently, large collaborative groups of researchers have formed consortia focused on asthma, with the goals of sharing material and data and standardizing diagnosis and experimental methods. Additionally, research has begun to focus on genetic variants that affect the response to asthma medications and on the biology that generates the heterogeneity in the asthma phenotype. As this work progresses, it will move asthma patients closer to more specific, personalized medicine. Keywords: asthma, genetics, GWAS, pharmacogenetics, biomarkers

  5. Enzymic characterization with progress curve analysis of a collagen peptidase from an enthomopathogenic bacterium, Photorhabdus luminescens.

    Science.gov (United States)

    Marokházi, Judit; Kóczán, György; Hudecz, Ferenc; Gráf, László; Fodor, András; Venekei, István

    2004-05-01

    A proteolytic enzyme, Php-B ( Photorhabdus protease B), was purified from the entomopathogenic bacterium, Photorhabdus luminescens. The enzyme is intracellular, and its molecular mass is 74 kDa. Tested on various peptide and oligopeptide substrates, Php-B hydrolysed only oligopeptides, with significant activity against bradykinin and a 2-furylacryloyl-blocked peptide, Fua-LGPA (2-furylacryloyl-Leu-Gly-Pro-Ala; kcat=3.6x10(2) s(-1), K(m)=5.8x10(-5) M(-1), pH optimum approx. 7.0). The p K(a1) and the p K(a2) values of the enzyme activity (6.1 and 7.9 respectively), as well as experiments with enzyme inhibitors and bivalent metal ions, suggest that the activity of Php-B is dependent on histidine and cysteine residues, but not on serine residues, and that it is a metalloprotease, which most probably uses Zn2+ as a catalytic ion. The enzyme's ability to cleave oligopeptides that contain a sequence similar to collagen repeat (-Pro-Xaa-Gly-), bradykinin and Fua-LGPA (a synthetic substrate for bacterial collagenases and collagen peptidases), but not native collagens (types I and IV) or denatured collagen (gelatin), indicates that Php-B is probably a collagen peptidase, the first enzyme of this type to be identified in an insect pathogen, that might have a role in the nutrition of P. luminescens by degrading small collagen fragments. For the determination of enzyme kinetic constants, we fitted a numerically integrated Michaelis-Menten model to the experimental progress curves. Since this approach has not been used before in the characterization of proteases that are specific for the P1'-P4' substrate sites (e.g. collagenolytic enzymes), we present a comparison of this method with more conventional ones. The results confirm the reliability of the numerical integration method in the kinetic analysis of collagen-peptide-hydrolysing enzymes. PMID:14744262

  6. Characterization of LEDGF/p75 genetic variants and association with HIV-1 disease progression.

    Directory of Open Access Journals (Sweden)

    Peter Messiaen

    Full Text Available BACKGROUND: As Lens epithelium-derived growth factor (LEDGF/p75 is an important co-factor involved in HIV-1 integration, the LEDGF/p75-IN interaction is a promising target for the new class of allosteric HIV integrase inhibitors (LEDGINs. Few data are available on the genetic variability of LEDGF/p75 and the influence on HIV disease in vivo. This study evaluated the relation between LEDGF/p75 genetic variation, mRNA expression and HIV-1 disease progression in order to guide future clinical use of LEDGINs. METHODS: Samples were derived from a therapy-naïve cohort at Ghent University Hospital and a Spanish long-term-non-progressor cohort. High-resolution melting curve analysis and Sanger sequencing were used to identify all single nucleotide polymorphisms (SNPs in the coding region, flanking intronic regions and full 3'UTR of LEDGF/p75. In addition, two intronic tagSNPs were screened based on previous indication of influencing HIV disease. LEDGF/p75 mRNA was quantified in patient peripheral blood mononuclear cells (PBMC using RT-qPCR. RESULTS: 325 samples were investigated from patients of Caucasian (n = 291 and African (n = 34 origin, including Elite (n = 49 and Viremic controllers (n = 62. 21 SNPs were identified, comprising five in the coding region and 16 in the non-coding regions and 3'UTR. The variants in the coding region were infrequent and had no major impact on protein structure according to SIFT and PolyPhen score. One intronic SNP (rs2737828 was significantly under-represented in Caucasian patients (P<0.0001 compared to healthy controls (HapMap. Two SNPs showed a non-significant trend towards association with slower disease progression but not with LEDGF/p75 expression. The observed variation in LEDGF/p75 expression was not correlated with disease progression. CONCLUSIONS: LEDGF/p75 is a highly conserved protein. Two non-coding polymorphisms were identified indicating a correlation with disease outcome, but further

  7. Progress in studies of natural gas conversion in China

    Institute of Scientific and Technical Information of China (English)

    Yu Changchun; Shen Shikong

    2008-01-01

    Progress in natural gas conversion in China is presented in this paper, including processes of natural gas to synthesis gas (syngas), syngas to liquid hydrocarbons, oxygenates synthesis, methanol to olefins (MTO), methane to aromatics and oxidative coupling of methane (OCM).

  8. Progress report no. 1 : Prairie grouse population and habitat studies

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Progress report on the wildlife management of prairie grouse. A census of sharp-tailed grouse dancing grounds was again made to determine the population for the...

  9. Studies of elementary particles: Progress report and proposal

    International Nuclear Information System (INIS)

    This progress report discusses the following High Energy Physics topics: the IMB/MIA detector; the MKII/HRS detector; the cosmic gamma-ray experiment; computer and instrumentation services; the MACRO detector; the DO detector; and spin physics

  10. Study on “Progressive Modular” Practice Teaching Model

    OpenAIRE

    Ying Han; Wei Zhao; Qing Liu; Xiang Qian

    2014-01-01

    Progressive modular” practice teaching model is the effective path of full and organic integration of theory and practice to explore increasing the cadre’s capacity to deal with complicated reality problems. To perfect further “progressive modular” practice teaching model, this teaching model must be thought as the important breakthrough of professional education reform to establish and perfect coordination system, to improve the comprehensive quality of teachers, to increase cooperation, un...

  11. Study of progressive depigmentation of dog′s muzzle

    Directory of Open Access Journals (Sweden)

    Shah K

    1991-01-01

    Full Text Available A new animal model is developed using dog′s muzzle to demonstrate progressive depigmen-tation after birth. Dog′s muzzle is heavily pigmented with pigment melanin and looks black in colour. Progressive depigmentation was observed two months after birth in a pup born with a depigmented mucous membrane of the mouth and lips. This resembles the vitiligo of humans.

  12. Memphis State University Center for Nuclear Studies progress report

    International Nuclear Information System (INIS)

    Progress made on the development of specialized education programs for the nuclear industry through the month of October, 1975, is outlined. The survey of the nuclear industry includes manpower resources and requirements of nuclear industry, annual training requirements of nuclear plants, and the educational curriculum for nuclear plant operational staff. Also discussed are the general organization of the project, student enrollment and progress and industrial participation

  13. Progress in preliminary studies at Ottana Solar Facility

    Science.gov (United States)

    Demontis, V.; Camerada, M.; Cau, G.; Cocco, D.; Damiano, A.; Melis, T.; Musio, M.

    2016-05-01

    The fast increasing share of distributed generation from non-programmable renewable energy sources, such as the strong penetration of photovoltaic technology in the distribution networks, has generated several problems for the management and security of the whole power grid. In order to meet the challenge of a significant share of solar energy in the electricity mix, several actions aimed at increasing the grid flexibility and its hosting capacity, as well as at improving the generation programmability, need to be investigated. This paper focuses on the ongoing preliminary studies at the Ottana Solar Facility, a new experimental power plant located in Sardinia (Italy) currently under construction, which will offer the possibility to progress in the study of solar plants integration in the power grid. The facility integrates a concentrating solar power (CSP) plant, including a thermal energy storage system and an organic Rankine cycle (ORC) unit, with a concentrating photovoltaic (CPV) plant and an electrical energy storage system. The facility has the main goal to assess in real operating conditions the small scale concentrating solar power technology and to study the integration of the two technologies and the storage systems to produce programmable and controllable power profiles. A model for the CSP plant yield was developed to assess different operational strategies that significantly influence the plant yearly yield and its global economic effectiveness. In particular, precise assumptions for the ORC module start-up operation behavior, based on discussions with the manufacturers and technical datasheets, will be described. Finally, the results of the analysis of the: "solar driven", "weather forecasts" and "combined storage state of charge (SOC)/ weather forecasts" operational strategies will be presented.

  14. Laser ablation/ionization characterization of solids: Second interim progress report of the strategic environmental research development program

    International Nuclear Information System (INIS)

    The Department of Energy is undertaking the enormous task of remediating defense wastes and environmental insults which have occurred over 50 years of nuclear weapons production. It is abundantly clear that significant technology advances are needed to characterize, process, and store highly radioactive waste and to remediate contaminated zones. In addition to the processing and waste form issues, analytical technologies needed for the characterization of solids, and for monitoring storage tanks and contaminated sites do not exist or are currently expensive labor-intensive tasks. This report describes progress in developing sensitive, rapid, and widely applicable laser-based mass spectrometry techniques for analysis of mixed chemical wastes and contaminated soils

  15. Site characterization studies in the NWTS program

    International Nuclear Information System (INIS)

    The US Department of Energy (DOE) has the responsibility to identify sites and construct and operate facilities for the storage or isolation of spent fuel and/or reprocessing radioactive wastes from commercial nuclear power plants. The National Waste Terminal Storage (NWTS) Program has been initiated by the DOE to develop the technology and demonstrate the feasibility of burial and isolation of high level radioactive waste in deep geologic formations. The NTWS Program plan which sets forth the criteria, procedures, and other considerations required to characterize and select a site in a comprehensive stepwise manner is discussed. The plan is not specific to any given geologic medium but serves as a guide for site selection in any geohydrologic system deemed appropriate for consideration for a deep geologic repository. The plan will be used by all NWTS Project Offices in the conduct of their site characterization program. The plan will be updated, as warranted, to reflect technology development, National policies, rulemakings by regulatory agencies, and other changing political, social, and institutional considerations. Site characterization begins with the identification of regions believed to have suitable geologic, hydrologic, and environmental characteristics for repository siting. This is followed by an iterative process of data collection and analysis to identify areas and locations which appear most suitable for further investigations. In addition, screening studies of the DOE's nuclear complexes has led to the selection of the Nevada Test Site and the Hanford Site for further characterization studies. The site characterization process results in a number of candidate sites from which a site will be selected and proposed to the NRC for licensing

  16. Fundamental chemistry, characterization, and separation of technetium complexes in Hanford waste. 1998 annual progress report

    International Nuclear Information System (INIS)

    'The ultimate goal of this proposal is to separate technetium from Hanford tank waste. The recent work has shown that a large portion of the technetium is not pertechnetate (TcO4-) and is not easily oxidized. This has serious repercussions for technetium partitioning schemes because they are designed to separate this chemical form. Rational attempts to oxidize these species to TcO4- for processing or to separate the non-pertechnetate species themselves would be facilitated by knowing the identity of these complexes and understanding their fundamental chemistry. Tank characterization work has not yet identified any of the non-pertechnetate species. However, based on the types of ligands available and the redox conditions in the tank, a reasonable speculation can be made about the types of species that may be present. Thus, this proposal will synthesize and characterize the relevant model complexes of Tc(III), Tc(IV), and Tc(V) that may have formed under tank waste conditions. Once synthesized, these complexes will be used as standards for developing and characterizing the non-pertechnetate species in actual waste using instrumental techniques such as capillary electrophoresis electrospray mass spectrometry (CE-MS), x-ray absorbance spectroscopy (EXAFS and XANES), and multi-nuclear NMR (including 99Tc NMR). The authors study the redox chemistry of the technetium complexes so that more efficient and selective oxidative methods can be used to bring these species to TcO4- for processing purposes. They will also study their ligand substitution chemistry which could be used to develop separation methods for non-pertechnetate species. Understanding the fundamental chemistry of these technetium complexes will enable technetium to be efficiently removed from the Hanford tank waste and help DOE to fulfill its remediation mission. This report summarizes the first 8 months of a 3-year project.'

  17. Progress in studies of gene therapy for Huntington's disease

    Directory of Open Access Journals (Sweden)

    JIN Fan-ying

    2012-06-01

    Full Text Available Huntington's disease (HD is a kind of inherited neurodegenerative disorder characterized by movement problems, cognitive decline and psychiatry disturbance. HD is caused by mutation in gene IT -15 involving the expansion of a trinucleotide (CAG repeat encoding glutamine, which leads to abnormal conformation of huntingtin (Htt protein and finally emerge cytotoxic functions. Currently, HD remains a fatal untreatable disease. Gene therapy for HD discussed in this review is under preclinical studies. Silencing of mutant IT-15 via RNA interference (RNAi or antisense oligonucleotide (ASO has shown some effectiveness in mouse model studies. Increasing the clearance of mutant Htt protein could be achieved by viral-mediated delivery of anti-Htt intrabodies (iAbs or induction of autophagy, and beneficial results have been observed. Ectopic expression of neurotrophic factors, such as nerve growth factor (NGF and brain-derived neurotrophic factor (BDNF, mediated either by viral vectors or transplantation of genetically modified cells, has also been proved to be effective. Other gene-modifying methods aiming at correction of transcriptional dysregulation by histone modification, activation of endogenous neural stem cells, and normalization of calcium signaling and mitochondrial function, are also under intensive research. Gene therapy for Huntington's disease is promising, yet a long way remains from preclinical studies to clinical trials.

  18. Collaborative Research: hydrogeological-geophysical methods for subsurface site characterization. 1998 annual progress report

    International Nuclear Information System (INIS)

    'The general purpose is the subsurface characterization of LLNL superfund site. The goal is to get the most accurate map of the hydrogeological parameters, necessary for modeling and designing the cleanup efforts at the site, using well log data and remote sensing geophysical techniques. In the second year of the project progress has been made in several areas: gathering and interpreting Vertical Seismic Profile (VSP) and Electromagnetic (EM) surveys; investigating the impact of various seismic measurements on upscaling of rock physics relations between sediment properties; and developing a new approach to integrate geophysical and hydrological data using state of the art methods to characterize the subsurface lithology. Vertical Seismic Profile data has been gathered from selected wells at the Treatment Facility D (TFD) during April 1996 and April 1998. The most striking finding here is the detection of anomalies related to saturation conditions. Preliminary results have revealed three anomalously low acoustic velocity zones with velocities below 1,000 m/s; this is lower than the natural acoustic velocity in saturated media by pure water (1,500 m/s). These three zones appear to be associated with HSUs 3a, 3b and 5. Velocities below 600 m/s have been revealed in the 3a and 3b HSUs (http://www.ce.Berkeley.edu/~ezzedine/DOE/paul.html). The authors believe that these anomalies are indicative of partial saturation. This explanation is supported by the water samples taken from pumping stations near the VSP well sites which appears to contain air bubbles. A gas analysis of water samples has not yet been performed. The authors hypothesize that this gas can be either air being sucked-in from the vadose zone above the water table, or from some chemical reaction. As a matter of fact, the natural water table level at this site was around 20 m below ground surface before any large scale pumping began, and had dropped to 25.5 m, in April 98. Furthermore, some of these low

  19. Morphologic Findings in Progressive Familial Intrahepatic Cholestasis 2 (PFIC2): Correlation With Genetic and Immunohistochemical Studies

    OpenAIRE

    Evason, Kimberley; Bove, Kevin E.; Finegold, Milton J; Knisely, A. S.; Rhee, Sue; Rosenthal, Philip; Miethke, Alexander G.; Karpen, Saul J; Ferrell, Linda D; Kim, Grace E.

    2011-01-01

    Progressive familial intrahepatic cholestasis, type 2 (PFIC2), characterized by cholestasis in infancy that may progress to cirrhosis, is caused by mutation in ABCB11, which encodes bile salt export pump (BSEP). We correlated histopathologic, immunohistochemical, and ultrastructural features in PFIC2 with specific mutations and clinical course. Twelve patients with clinical PFIC2 and ABCB11 mutations were identified, and 22 liver biopsy and explant specimens were assessed. All had hepatocellu...

  20. Studying protein-protein interactions: progress, pitfalls and solutions.

    Science.gov (United States)

    Hayes, Sheri; Malacrida, Beatrice; Kiely, Maeve; Kiely, Patrick A

    2016-08-15

    Signalling proteins are intrinsic to all biological processes and interact with each other in tightly regulated and orchestrated signalling complexes and pathways. Characterization of protein binding can help to elucidate protein function within signalling pathways. This information is vital for researchers to gain a more comprehensive knowledge of cellular networks which can then be used to develop new therapeutic strategies for disease. However, studying protein-protein interactions (PPIs) can be challenging as the interactions can be extremely transient downstream of specific environmental cues. There are many powerful techniques currently available to identify and confirm PPIs. Choosing the most appropriate range of techniques merits serious consideration. The aim of this review is to provide a starting point for researchers embarking on a PPI study. We provide an overview and point of reference for some of the many methods available to identify interactions from in silico analysis and large scale screening tools through to the methods used to validate potential PPIs. We discuss the advantages and disadvantages of each method and we also provide a workflow chart to highlight the main experimental questions to consider when planning cell lysis to maximize experimental success. PMID:27528744

  1. Studies on GaN-based laser devices make progress

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ A research team led by YANG Hui and CHEN Lianghui with the CAS Institute of Semiconductors (ISCAS) has made breakthrough progress in addressing key technological problems for the GaN-based laser diodes development. The research results were spoken highly at a panel meeting of experts held on 26 November, 2007 in Beijing.

  2. Studies in iodine metabolism. Progress report, 1982-1983

    International Nuclear Information System (INIS)

    Research progress is reported for the period 1982 to 1983 in the following areas: (1) monitoring of animal thyroids for 129I, 125I, 131I, 226Ra, and 228Ra; and (2) neonatal hypo-l thyroidism in laboratory rats

  3. Damage analysis and fundamental studies. Quarterly progress report, January--March 1979

    Energy Technology Data Exchange (ETDEWEB)

    Zwilsky, Klaus M.

    1979-05-01

    This report is the fifth in a series of Quarterly Technical Progress Reports on Damage Analysis and Fundamental Studies (DAFS) which is one element of the Fusion Reactor Materials Program, conducted in support of the Magnetic Fusion Energy Program. This report is organized along topical lines in parallel to a Program Plan of the same title (to be published) so that activities and accomplishments may be followed readily relative to that Program Plan. Thus, the work of a given laboratory may appear throughout the report. Chapters 1 and 2 report topics which are generic to all of the DAFS Program: DAFS Task Group Activities and Irradiation Test Facilities, respectively. Chapters 3, 4, and 5 report the work that is specific to each of the subtasks around which the program is structured: A) Environmental Characterization, B) Damage Production, and C) Damage Microstructure Evolution and Mechanical Behavior.

  4. Characterization of the Variability of Epstein-Barr Virus Genes in Nasopharyngeal Biopsies: Potential Predictors for Carcinoma Progression

    Science.gov (United States)

    Banko, Ana V.; Lazarevic, Ivana B.; Folic, Miljan M.; Djukic, Vojko B.; Cirkovic, Andja M.; Karalic, Danijela Z.; Cupic, Maja D.; Jovanovic, Tanja P.

    2016-01-01

    Epstein-Barr virus (EBV) infection is a significant factor in the pathogenesis of nasopharyngeal carcinoma, especially in the undifferentiated carcinoma of nasopharyngeal type (UCNT, World Health Organization type III), which is the dominant histopathological type in high-risk areas. The major EBV oncogene is latent membrane protein 1 (LMP1). LMP1 gene shows variability with different tumorigenic and immunogenic potentials. EBV nuclear antigen 1 (EBNA1) regulates progression of EBV-related tumors; however, the influence of EBNA1 sequence variability on tumor pathogenesis is controversial. The aims of this study were to characterize polymorphisms of EBV genes in non-endemic nasopharyngeal carcinoma biopsies and to investigate potential sequence patterns that correlate with the clinical presentation of nasopharyngeal carcinoma. In total, 116 tumor biopsies of undifferentiated carcinoma of nasopharyngeal type (UCNT), collected from 2008 to 2014, were evaluated in this study. The genes EBNA2, LMP1, and EBNA1 were amplified using nested-PCR. EBNA2 genotyping was performed by visualization of PCR products using gel electrophoresis. Investigation of LMP1 and EBNA1 included sequence, phylogenetic, and statistical analyses. The presence of EBV DNA was significantly distributed between TNM stages. LMP1 variability showed six variants, with the detection of the first China1 and North Carolina variants in European nasopharyngeal carcinoma biopsies. Newly discovered variants Srb1 and Srb2 were UCNT-specific LMP1 polymorphisms. The B95-8 and North Carolina variants are possible predictors for favorable TNM stages. In contrast, deletions in LMP1 are possible risk factors for the most disfavorable TNM stage, independent of EBNA2 or EBNA1 variability. A newly discovered EBNA1 subvariant, P-thr-sv-5, could be a potential diagnostic marker, as it represented a UCNT-specific EBNA1 subvariant. A particular combination of EBNA2, LMP1, and EBNA1 polymorphisms, type 1/Med/P-thr was

  5. Molecular studies of functional aspects of plant mitochondria. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Siedow, J.N.

    1992-03-03

    The goal of this research is to characterize the mechanism by which a protein encoded by mitochondrial genome of cms-T maize (URF13) interacts with a family of the compounds produced by certain fungi (T-toxins) to permeabilize biological membranes. The research carried out during the current funding period has focused on the structure of URF13, and the results support the validity of the three-helix model of URF13 and provide direct evidence for the oligomeric nature of at least some of the URF13 molecules in the membrane. In addition, the toxin binding studies have provided insight into the dynamic nature of the T-toxin:URF13 interaction and the extent to which Asp-39 is crucial to the interaction that leads to membrane pore formation. Additional knowledge of the structure of URF13 is needed if the nature of the interaction between URF13 and T-toxin to produce a hydrophilic pore within the membrane is to ultimately be understood.

  6. Collaborative research: Hydrogeological-geophysical methods for subsurface site characterization. 1997 annual progress report

    International Nuclear Information System (INIS)

    'In the first year of the project progress has been made in several areas which are central to the project. Development of Joint Hydrogcological-Geophysical Co-Interpretation Procedure A strong effort was invested in developing the concepts and the algorithm of the joint hydrogeological-geophysical co-interpretation approach. The reason for the concerted effort in that direction is the large amount of time the authors expect this task will take before completion, and also by the need to direct the data collection efforts. They are currently testing several ideas for co-interpretation, but they are at a quite advanced stage. They are testing these ideas using synthetic studies as well as some preliminary data that has been collected at the Lawrence Livermore National Lab site. Part of the efforts is in developing methods for estimation of the semi-variograms of the logconductivity based on direct measurements as well as on seimsic velocity measurements as obtained from cross-well tomography. Preliminary tests show that these two sources of data complement each other quite well: the direct measurements supply the medium to small wave number portion of the logconductivity spectra, while a high resolution seismic survey supplies a good coverage of the large wave number part of the spectra. They advanced significantly with formulating their approach for using Ground Penetrating Radar (GPR) imaging techniques in shallow subsurface surveys. Synthetic surveys show that GPR maybe very suitable for mapping spatial variations in saturations. They have access to field data and are analyzing it. Some additional issues that were investigated are also listed.'

  7. Progress study of the cardiac damage in Duchenne muscular dystrophy

    OpenAIRE

    Zhang, Yao; Tang, Ying; Zhang, Cheng

    2013-01-01

    Duchenne muscular dystrophy (DMD) is a fatal muscular disease with rapid progression in children. Most patients die of respiratory and circulatory failure before the age of 20 if there is no systematic treatment. Now the heart problem in this disease has become increasingly prominent, and is thought to be closely associated with certain dystrophin exon deletion. We would like to review the epidemiology, relevance of dystrophin, pathogenesis, clinical manifestations and pathological features, ...

  8. Progression of hepatic fibrosis in patients with hepatitis C: a prospective repeat liver biopsy study

    OpenAIRE

    Ryder, S. D.

    2004-01-01

    Background: The natural history of hepatitis C virus (HCV) infection remains uncertain. Previous data concerning rates of progression are from studies using estimated dates of infection and single liver biopsy scores. We prospectively studied the rate of progression of fibrosis in HCV infected patients by repeat liver biopsies without intervening treatment.

  9. Characterization of ionizing radiation damage in DNA. Progress report, May 1, 1975--April 30, 1976

    International Nuclear Information System (INIS)

    The objective of this research is the characterization and quantitative assay of ionizing radiation-induced damage in DNA and nucleoprotein. Two lines of investigation have been pursued. The first is aimed at detection and assay of DNA to protein covalent cross linkage in coliphage T7. Protein and DNA are labeled with 14C and 32P, respectively. Cross linkage is assessed from the amount of labeled protein distributing like DNA and labeled DNA distributing like protein on a phenol-water countercurrent distribution system. It has been found that damage involving cross linkage occurs by two modes of radiation action in phage irradiated with 60Co γ rays in .001M histidine medium. Indirect effects play a large role in one mode and direct effects play a large role in the other. In the second line of investigation, the hydrodynamic and viscoelastic properties of DNA from irradiated phage and cells will be examined to determine the extent to which DNA to DNA cross linkage and points of altered flexibility are introduced by radiation. An instrument for viscoelastic measurements has been constructed in preparation for these studies

  10. Is nonangiogenesis a novel pathway for cancer progression? A study using 3-dimensional tumour reconstructions

    OpenAIRE

    Adighibe, O; Micklem, K; Campo, L; Ferguson, M.; Harris, A; Pozos, R; Gatter, K; Pezzella, F.

    2006-01-01

    The nonangiogenic lung tumour is characterized by neoplastic cells co-opting the pre-existent vasculature and filling the alveoli space. 3-Dimensional reconstruction of the tumour reveals that this particular tumour progresses without neovascularization and there is no major destruction of the lung's architectural integrity.

  11. Progress in the application study of biliary endoprosthesis

    International Nuclear Information System (INIS)

    Biliary endoprosthesis, including plastic stents and metallic stents, have been widely used in the management of various benign or malignant bile duct stenosis. Although the short-term effect is most satisfactory, the long-term result is unsatisfactory because of the displacement and restenosis of the stent. Metallic stent is superior to plastic stent in keeping the stent open for long time and the technique has been improved gradually. This paper aims to make a review of the related literatures and to summarize the recent progress in the applied research. (authors)

  12. Progress study of the cardiac damage in Duchenne muscular dystrophy

    Directory of Open Access Journals (Sweden)

    ZHANG Yao

    2013-05-01

    Full Text Available Duchenne muscular dystrophy (DMD is a fatal muscular disease with rapid progression in children. Most patients die of respiratory and circulatory failure before the age of 20 if there is no systematic treatment. Now the heart problem in this disease has become increasingly prominent, and is thought to be closely associated with certain dystrophin exon deletion. We would like to review the epidemiology, relevance of dystrophin, pathogenesis, clinical manifestations and pathological features, as well as early prevention and treatment of DMD.

  13. Chemical and geochemical studies off the coast of Washington. Progress report, September 1978-August 1979

    International Nuclear Information System (INIS)

    Progress on a series of marine chemical and geochemical investigations involving both laboratory studies and field studies off the coast of Washington are summarized. Most of the field work has been on the Washington continental shelf, slope, and the submarine canyons indenting the shelf north of the Columbia River. The aim is to provide basic data required to characterize underlying chemical and physical processes and their rates which control the distributions, concentrations, and ultimate fate of some of the potentially hazardous agents associated with fossil fuel and nuclear power production or transportation. The studies have followed several main lines of investigation which are in various stages of completion: (1) field studies of the uptake and transport by zooplankton fecal pellets of 210Po, 210Pb, and other trace inorganic and organic constituents in a well-studied part of Puget Sound; (2) studies of the behavior of 210Po and 210Pb in sediments off the coast of Washington and the application of the 210Pb determinations in sediment cores to determine sediment accumulation rates for the past 100 years, the depth of the surface mixed layer, and a mixing coefficient for the surface sediments; and (3) investigations of aliphatic and aromatic hydrocarbons in some of the same samples of organisms and sediment cores whose accumulation histories for the past 100 years we have determined with the 210Pb technique

  14. Recent Progress in Studies of Climate Change in China

    Institute of Scientific and Technical Information of China (English)

    REN Guoyu; DING Yihui; ZHAO Zongci; ZHENG Jingyun; WU Tongwen; TANG Guoli; XU Ying

    2012-01-01

    An overview of basic research on climate change in recent years in China is presented. In the past 100 years in China,average annual mean surface air temperature (SAT) has increased at a rate ranging from 0.03℃ (10 yr)-1 to 0.12℃ (10 yr)-1.This warming is more evident in northern China and is more significant in winter and spring.In the past 50 years in China,at least 27% of the average annual warming has been caused by urbanization.Overall,no significant trends have been detected in annual and/or summer precipitation in China on a whole for the past 100 years or 50 years. Both increases and decreases in frequencies of major extreme climate events have been observed for the past 50 years. The frequencies of extreme temperature events have generally displayed a consistent pattern of change across the country,while the frequencies of extreme precipitation events have shown only regionally and seasonally significant trends.The frequency of tropical cyclone landfall decreased slightly,but the frequency of sand/dust storms decreased significantly.Proxy records indicate that the annual mean SAT in the past a few decades is the highest in the past 400-500 years in China,but it may not have exceeded the highest level of the Medieval Warm Period (1000-1300 AD).Proxy records also indicate that droughts and floods in eastern China have been characterized by continuously abnormal rainfall periods,with the frequencies of extreme droughts and floods in the 20th century most likely being near the average levels of the past 2000 years.The attribution studies suggest that increasing greenhouse gas (GHG) concentrations in the atmosphere are likely to be a main factor for the observed surface warming nationwide.The Yangtze River and Huaihe River basins underwent a cooling trend in summer over the past 50 years,which might have been caused by increased aerosol concentrations and cloud cover.However,natural climate variability might have been a main driver for the mean and

  15. Progress in spondylarthritis. Progress in studies of the genetics of ankylosing spondylitis

    OpenAIRE

    Brown, Matthew A.

    2009-01-01

    The advent of high-throughput SNP genotyping methods has advanced research into the genetics of common complex genetic diseases such as ankylosing spondylitis (AS) rapidly in recent times. The identification of associations with the genes IL23R and ERAP1 have been robustly replicated, and advances have been made in studies of the major histocompatibility complex genetics of AS, and of KIR gene variants and the disease. The findings are already being translated into increased understanding of ...

  16. Chemical and geochemical studies off the coast of Washington. Report of progress, May 1975--May 1976

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, R. (comp.)

    1976-05-01

    This report summarizes progress from May 1975 to May 1976 on a series of marine chemical and geochemical investigations involving both laboratory studies and field studies off the coast of Washington north of the Columbia River. Data are included from surface chemical studies of the scavenging of various species dissolved in sea water, especially lead-210, by well characterized natural particulates; studies of uptake and transfer of several isotopes, starting with polonium-210, by particularly well defined parts of the marine food web; studies of the behavior of lead-210 and polonium-210 in sediments off the Washington coast and the application of lead-210 dating to determine sediment accumulation rates over the past 100 years in the coastal zone, and investigations of aliphatic and aromatic hydrocarbons in some of the same samples of surf zone diatoms, neuston organisms, salmon, and shrimp at different life stages, and in sediment cores whose accumulation histories over the last 100 years were determined with the lead-210 technique.

  17. Kodiak Island bald eagle migration and movements study: Progress report update

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report updates the progress of a bald eagle migration and movements study begun during July, 1982. The study objectives are: 1 to determine and compare...

  18. Kodiak Island bald eagle migration and movements study: Progress report update

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report updates the progress of a bald eagle migration and movements study begun during July, 1982. The study objectives are: (1) to determine and compare...

  19. 1984 Pacific walrus harvest, health, and welfare study at Little Diomede Island, Alaska: Progress report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report is a progress update on the Pacific walrus harvest study that has been conducted in Diomede, Alaska in previous years. Study methods and results are...

  20. Kodiak Island bald eagle migration and movements study: Progress report, update

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this report is to update the progress of the bald eagle migration and movements study begun during July of 1982. The study objectives are: to...

  1. Progress on the europium neutron capture study using DANCE

    International Nuclear Information System (INIS)

    The accurate measurement of neutron capture cross sections of the Eu isotopes is important for many reasons including nuclear astrophysics and nuclear diagnostics. Neutron capture excitation functions of 151,153Eu targets were measured recently using a 4π γ-ray calorimeter array DANCE located at the Los Alamos Neutron Science Center for E n = 0.1-100 keV. The progress on the data analysis efforts is given in the present paper. The γ-ray multiplicity distributions for the Eu targets and Be backing are significantly different. The γ-ray multiplicity distribution is found to be the same for different neutron energies for both 151Eu and 153Eu. The statistical simulation to model the γ-ray decay cascade is summarized

  2. Progress on the Europium Neutron-Capture Study using DANCE

    International Nuclear Information System (INIS)

    The accurate measurement of neutron-capture cross sections of the Eu isotopes is important for many reasons including nuclear astrophysics and nuclear diagnostics. Neutron capture excitation functions of 151,153Eu targets were measured recently using a 4π γ-ray calorimeter array DANCE located at the Los Alamos Neutron Science Center for En = 0.1-100 keV. The progress on the data analysis efforts is given in the present paper. The γ-ray multiplicity distributions for the Eu targets and Be backing are significantly different. The γ-ray multiplicity distribution is found to be the same for different neutron energies for both 151Eu and 153Eu. The statistical simulation to model the γ-ray decay cascade is summarized

  3. Progress on the europium neutron capture study using DANCE

    Energy Technology Data Exchange (ETDEWEB)

    Agvaanluvsan, U. [Lawrence Livermore National Laboratory, 7000 East Avenue, P.O. Box 808, L-414, Livermore, CA 94551 (United States)]. E-mail: agvaanluvsan1@llnl.gov; Becker, J.A. [Lawrence Livermore National Laboratory, 7000 East Avenue, P.O. Box 808, L-414, Livermore, CA 94551 (United States); Macri, R.A. [Lawrence Livermore National Laboratory, 7000 East Avenue, P.O. Box 808, L-414, Livermore, CA 94551 (United States); Parker, W. [Lawrence Livermore National Laboratory, 7000 East Avenue, P.O. Box 808, L-414, Livermore, CA 94551 (United States); Wilk, P. [Lawrence Livermore National Laboratory, 7000 East Avenue, P.O. Box 808, L-414, Livermore, CA 94551 (United States); Wu, C.Y. [Lawrence Livermore National Laboratory, 7000 East Avenue, P.O. Box 808, L-414, Livermore, CA 94551 (United States); Bredeweg, T.A.; Esch, E.; Haight, R.C.; O' Donnell, J.M.; Reifarth, R.; Rundberg, R.S.; Schwantes, J.M.; Ullmann, J.L.; Vieira, D.J.; Wilhelmy, J.B.; Wouters, J.M. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Mitchell, G.E.; Sheets, S. [North Carolina State University, Raleigh, NC 27695 (United States)]|[Triangle Universities Nuclear Laboratory, Durham, NC 27708 (United States); Becvar, F.; Krticka, M. [Charles University in Prague, CZ 180 00 Prague 8 (Czech Republic)

    2007-08-15

    The accurate measurement of neutron capture cross sections of the Eu isotopes is important for many reasons including nuclear astrophysics and nuclear diagnostics. Neutron capture excitation functions of {sup 151,153}Eu targets were measured recently using a 4{pi} {gamma}-ray calorimeter array DANCE located at the Los Alamos Neutron Science Center for E {sub n} = 0.1-100 keV. The progress on the data analysis efforts is given in the present paper. The {gamma}-ray multiplicity distributions for the Eu targets and Be backing are significantly different. The {gamma}-ray multiplicity distribution is found to be the same for different neutron energies for both {sup 151}Eu and {sup 153}Eu. The statistical simulation to model the {gamma}-ray decay cascade is summarized.

  4. Progress on the Europium Neutron-Capture Study using DANCE

    Energy Technology Data Exchange (ETDEWEB)

    Agvaanluvsan, U; Becker, J A; Macri, R A; Parker, W; Wilk, P; Wu, C Y; Bredeweg, T A; Esch, E; Haight, R C; O' Donnell, J M; Reifarth, R; Rundberg, R S; Schwantes, J M; Ullmann, J L; Vieira, D J; Wilhelmy, J B; Wouters, J M; Mitchell, G E; Sheets, S A; Becvar, F; Krticka, M

    2006-09-05

    The accurate measurement of neutron-capture cross sections of the Eu isotopes is important for many reasons including nuclear astrophysics and nuclear diagnostics. Neutron capture excitation functions of {sup 151,153}Eu targets were measured recently using a 4{pi} {gamma}-ray calorimeter array DANCE located at the Los Alamos Neutron Science Center for E{sub n} = 0.1-100 keV. The progress on the data analysis efforts is given in the present paper. The {gamma}-ray multiplicity distributions for the Eu targets and Be backing are significantly different. The {gamma}-ray multiplicity distribution is found to be the same for different neutron energies for both {sup 151}Eu and {sup 153}Eu. The statistical simulation to model the {gamma}-ray decay cascade is summarized.

  5. The Perceptions of Women's Roles and Progress: A Study of Malay Women

    Science.gov (United States)

    Abdullah, Kalthom; Noor, Noraini M.; Wok, Saodah

    2008-01-01

    This study examines the general perceptions of women towards their roles, their interpretation of progress, as well as the facilitating factors and barriers to their progress. Questionnaires were distributed to 1,000 Malay women in Malaysia from rural and urban areas, from various age and income groups. Interviews were also carried out on the…

  6. Brazilian oil spills chemical characterization : case studies

    International Nuclear Information System (INIS)

    The Petrobras Research Centre has been active in responding to some significant oil spills in Brazil in the past decade. The centre has characterized spilled oil, monitored the affected ecosystems and determined the fate of oil in the environment. This paper described the use of some advanced chemical analytical techniques used in Brazilian oil spill studies to determine fractions and individual petroleum hydrocarbons in water, groundwater, sediment, sand, fish and the spilled oil itself. Some of the most recent oil spill cases were discussed in terms of chemical characterization of the spilled oil and the environmental samples from different matrices of the affected ecosystems for determining the fate of the oil in the environment and to assess environmental damage. In particular, methods such as gas chromatography/flame ionization detector, P and T/GC/PID and gas chromatography/mass spectrometry have been used to examine crude and fuel oil spills in Guanabara Bay, Barigui and Iguassu Rivers, and the Sao Sebastiao Channel. The chemical analytical methods are used to determine total petroleum hydrocarbons, n-alkanes, isoprenoids, unresolved complex mixtures, volatile monoaromatic compounds such as BTEX (benzene, toluene, ethylbenzene and xylenes), as well as parent and alkylated homologues polycyclic aromatic hydrocarbons (PAH) and terpanes and steranes. Acute ecotoxicity data for water and sediment samples was also included. It was determined that with certain limitations, PAH ratios can help determine the origin of hydrocarbons as being either petrogenic or pyrolytic. However, alkylated PAH homologues and parent compounds such as dibenzothiophene and perylene give more precise interpretation of the data. 30 refs., 9 tabs., 11 figs

  7. Nuclear Waste Management. Semiannual progress report, October 1984-March 1985

    International Nuclear Information System (INIS)

    Progress reports are presented for the following studies on radioactive waste management: defense waste technology; nuclear waste materials characterization center; and supporting studies. 19 figs., 29 tabs

  8. Nuclear waste management. Semiannual progress report, October 1983-March 1984

    International Nuclear Information System (INIS)

    Progress in the following studies on radioactive waste management is reported: defense waste technology; Nuclear Waste Materials Characterization Center; waste isolation; and supporting studies. 58 figures, 22 tables

  9. Nuclear Waste Management. Semiannual progress report, October 1984-March 1985

    Energy Technology Data Exchange (ETDEWEB)

    McElroy, J.L.; Powell, J.A. (comps.)

    1985-06-01

    Progress reports are presented for the following studies on radioactive waste management: defense waste technology; nuclear waste materials characterization center; and supporting studies. 19 figs., 29 tabs.

  10. Characterization of low and medium-level radioactive waste forms. Joint annual progress report 1982

    International Nuclear Information System (INIS)

    The work reported was carried out during the second year of the Commission of the European Communities programme on the characterization of low and medium-level waste forms. Ten reference waste forms plus others of special national interest have been identified covering PWR, BWR, GCR and reprocessing wastes. The immobilizing media include the three main matrices: cement, polymers and bitumen, and a glass. Characterization is viewed as one input to quality assurance of the waste form and covers: waste-matrix compatibility, radiation effects, leaching, microbiological attack, shrinkage and swelling, ageing processes and thermal effects. The aim is a balanced programme of comparative data, predictive modelling and an understanding of basic mechanisms

  11. Cartilage tumour progression is characterized by an increased expression of heparan sulphate 6O-sulphation-modifying enzymes.

    Science.gov (United States)

    Waaijer, Cathelijn J F; de Andrea, Carlos E; Hamilton, Andrew; van Oosterwijk, Jolieke G; Stringer, Sally E; Bovée, Judith V M G

    2012-10-01

    Chondrosarcomas are malignant cartilage-forming tumours that can arise centrally (in the medulla) or peripherally (at the surface) of the bone. They are classified into three histological grades which correspond to the clinical severity. Previous studies by our group have shown altered signal transduction of the fibroblast growth factor and Wnt signalling pathways during peripheral chondrosarcoma progression. Heparan sulphate (HS) is a glycosaminoglycan that facilitates receptor binding of multiple growth factors, in which the sulphation of 6O position plays a pivotal role. 6O-Sulphation occurs through three HS 6O-sulphotransferases (HS6ST1-3) and is fine-tuned by two endosulphatases (SULF1-2) that remove 6O-sulphate groups. We have investigated whether the expression of HS6STs and SULFs changes during chondrosarcoma progression and have determined 6O-sulphation levels in two chondrosarcoma cell lines. Immunohistochemistry on tissue microarrays of chondrosarcomas showed that HS6ST3 and SULF1 were highly expressed in most chondrosarcomas, whereas SULF2 expression was absent in most cases. HS6ST1 and HS6ST2 expression are significantly increased during chondrosarcoma progression, which suggest that 6O-sulphation is increased during progression. This was confirmed in one grade III chondrosarcoma cell line, which showed a dramatically increased 6O-sulphation compared to an articular chondrocyte cell line by HPLC; another cell line showed an increased expression of one 6O-sulphated HS disaccharide. In conclusion, our results show increased HS6ST1 and HS6ST2 expression during chondrosarcoma progression and increased HS 6O-sulphation in vitro. As 6O-sulphation plays an important role in signal transduction, altered HS6ST expression might be associated with changes in signal transduction pathways in chondrosarcoma progression. PMID:22903264

  12. Radioelement studies in the oceans. Progress report, April 15, 1981-April 14, 1982

    International Nuclear Information System (INIS)

    Progress for the report period is reported under the following section headings: bibliographic summary - 1981; cruise reports and sampling activities; abstracts of reports published, submitted, or presented at meetings; and, brief summaries of work in progress. Research in progress includes the following studies: post-depositional chemistry of radionuclides: interstitial water composition and laboratory remobilizaton studies; thorium isotope studies in seawater; radionuclide measurements on samples from ocean weather ship MIKE, in the Norwegian Sea; counting technique optimization for Cs isotopes collected by chemisorption; Pu oxidation states in the Aleutian Trench water column; intercalibrations and standard materials; and radionuclides in deep water bathypelagic biota

  13. Chemical and geochemical studies off the coast of Washington. Progress report, September 1980-July 1981

    International Nuclear Information System (INIS)

    This report summarizes progress from September 1980 through July 1981 on a series of marine chemical and geochemical investigations involving both laboratory studies and field studies off the coast of Washington. Most of the field work has been on the Washington continental shelf, slope, and the submarine canyons indenting the shelf north of the Columbia River. The aim is to provide basic data required to characterize underlying chemical and physical processes and their rates which control the distributions, concentrations, and ultimate fate of some of the potentially hazardous agents associated with fossil fuel and/or nuclear power production or transportation. We are concentrating on several processes which we feel are of special importance in the sea, and developing methodologies and expertise to study them. Laboratory and field experiments and theories derived from them are being used iteratively to investigate: (1) vertical transfer of trace chemicals from surface seawaters to underlying waters and sediments; (2) processes which may transfer certain chemicals from sediments back into the overlying water column; (3) redox processes which besides changing valence states of certain chemicals may alter their precipitation/dissolution tendencies, their biological availability and/or toxicity; and (4) accumulation histories of potentially hazardous chemicals in sediments during the past 100 years

  14. Recent Progress and Perspectives in the Electrokinetic Characterization of Polyelectrolyte Films

    Directory of Open Access Journals (Sweden)

    Ralf Zimmermann

    2015-12-01

    Full Text Available The analysis of the charge, structure and molecular interactions of/within polymeric substrates defines an important analytical challenge in materials science. Accordingly, advanced electrokinetic methods and theories have been developed to investigate the charging mechanisms and structure of soft material coatings. In particular, there has been significant progress in the quantitative interpretation of streaming current and surface conductivity data of polymeric films from the application of recent theories developed for the electrohydrodynamics of diffuse soft planar interfaces. Here, we review the theory and experimental strategies to analyze the interrelations of the charge and structure of polyelectrolyte layers supported by planar carriers under electrokinetic conditions. To illustrate the options arising from these developments, we discuss experimental and simulation data for plasma-immobilized poly(acrylic acid films and for a polyelectrolyte bilayer consisting of poly(ethylene imine and poly(acrylic acid. Finally, we briefly outline potential future developments in the field of the electrokinetics of polyelectrolyte layers.

  15. Coal liquefaction process streams characterization and evaluation. Quarterly technical progress report, October 1--December 31, 1991

    Energy Technology Data Exchange (ETDEWEB)

    Robbins, G.A.; Brandes, S.D.; Winschel, R.A.; Burke, F.P.

    1992-03-01

    CONSOL R&D is conducting a three-year program to characterize process and product streams from direct coal liquefaction process development projects. The program objectives are two-fold: (1) to obtain and provide appropriate samples of coal liquids for the evaluation of analytical methodology, and (2) to support ongoing DOE-sponsored coal liquefaction process development efforts. The two broad objectives have considerable overlap and together serve to provide a bridge between process development and analytical chemistry.

  16. Coal liquefaction process streams characterization and evaluation. Quarterly technical progress report, July 1--September 30, 1991

    Energy Technology Data Exchange (ETDEWEB)

    Winschel, R.A.; Brandes, S.D.; Robbins, G.A.; Burke, F.P.

    1991-11-01

    Consol R&D is conducting a three-year program to characterize process and product streams from direct coal liquefaction process development projects. The program objectives are two-field: (1) to obtain and provide appropriate samples of coal liquids for the evaluation of analytical methodology, and (2) to support ongoing DOE-sponsored coal liquefaction process development efforts. The two broad objectives have considerable overlap and together serve to provide a bridge between process development and analytical chemistry.

  17. A study on the late core melt progression in pressurized water reactor severe accidents

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jae Hong; Jeun Gyoo Dong; Bang, Kwang Hyun; Park, Seh In; Lim, Jae Hyuck; Park, Seong Yong [Hanyang Univ., Seoul (Korea, Republic of); Back, Hyung Hmm [Korea Maritime Univ., Busan (Korea, Republic of)

    1998-03-15

    After TMI-2 accidents, it has been paid much attention to severe accidents beyond the design basis accidents and the research on the progress of severe accidents and mitigation and the closure of severe accidents has been actively performed. In particular, a great deal of uncertainties yet exist in the phase of late core melt progression and thus the research on this phase of severe accident progress has a key role in obtaining in severe accident mitigation and nuclear reactor safety. In the present study, physics of late core melt progression, experimental data and the major phenomenological models of computer codes are reviewed and a direction of reducing the uncertainties in the late core melt progression os proposed.

  18. Models of endometriosis and their utility in studying progression to ovarian clear cell carcinoma.

    Science.gov (United States)

    King, Claire M; Barbara, Cynthia; Prentice, Andrew; Brenton, James D; Charnock-Jones, D Stephen

    2016-01-01

    Endometriosis is a common benign gynaecological condition affecting at least 10% of women of childbearing age and is characterized by pain--frequently debilitating. Although the exact prevalence is unknown, the economic burden is substantial (∼$50 billion a year in the USA alone) and it is associated with considerable morbidity. The development of endometriosis is inextricably linked to the process of menstruation and thus the models that best recapitulate the human disease are in menstruating non-human primates. However, the use of these animals is ethically challenging and very expensive. A variety of models in laboratory animals have been developed and the most recent are based on generating menstrual-like endometrial tissue that can be transferred to a recipient animal. These models are genetically manipulable and facilitate precise mechanistic studies. In addition, these models can be used to study malignant transformation in epithelial ovarian carcinoma. Epidemiological and molecular evidence indicates that endometriosis is the most plausible precursor of both clear cell and endometrioid ovarian cancer (OCCA and OEA, respectively). While this progression is rare, understanding the underlying mechanisms of transformation may offer new strategies for prevention and therapy. Our ability to pursue this is highly dependent on improved animal models but the current transgenic models, which genetically modify the ovarian surface epithelium and oviduct, are poor models of ectopic endometrial tissue. In this review we describe the various models of endometriosis and discuss how they may be applicable to developing our mechanistic understanding of OCCA and OEA. PMID:26456077

  19. Academic dismissal policy for medical students: effect on study progress and help-seeking behaviour

    OpenAIRE

    Stegers-Jager, Karen M.; Cohen-Schotanus, Janke; Splinter, Ted A.W.; Themmen, Axel P.N.

    2011-01-01

    CONTEXT Medical students often fail to finish medical school within the designated time. An academic dismissal (AD) policy aims to enforce satisfactory progress and to enable early identification and timely support or referral of struggling students. In this study, we assessed whether the implementation of an AD policy improved study progress in the first 2 years of medical school. Additionally, we analysed its effect on the help-seeking behaviour of struggling students. METHODS We compared t...

  20. Progress research report, 27 June, 1983, benthic invertebrate studies

    International Nuclear Information System (INIS)

    The benthic ecological research at site W-N for the Low Level Waste Ocean Disposal Program is oriented towards characterizing the invertebrate community associated with the seafloor and towards understanding the links within the benthic food web. Stomach analyses of benthic-feeding fishes reveal a varied diet of benthic and peloagio-benthic forms. From the trawl samples of megafauna, the basic community structure is similar to other deep-sea areas with echinoderms as the predominant forms. For the macrofauna, polychaete worms comprise the dominant taxonomic group. Very little is known about the fauna at area W-N on the species level. Such data will help answer the question of whether this community is characteristic of the continental slope base or is a transition between continentally-influenced communities and those in the central portion of ocean basins. Environmental differences within the area suggest that the benthic fauna should also vary in composition and abundance. 19 references, 7 figures, 5 tables

  1. Evaluation of Study and Patient Characteristics of Clinical Studies in Primary Progressive Multiple Sclerosis: A Systematic Review.

    Directory of Open Access Journals (Sweden)

    T Ziemssen

    Full Text Available So far, clinical studies in primary progressive MS (PPMS have failed to meet their primary efficacy endpoints. To some extent this might be attributable to the choice of assessments or to the selection of the study population.The aim of this study was to identify outcome influencing factors by analyzing the design and methods of previous randomized studies in PPMS patients without restriction to intervention or comparator.A systematic literature search was conducted in MEDLINE, EMBASE, BIOSIS and the COCHRANE Central Register of Controlled Trials (inception to February 2015. Keywords included PPMS, primary progressive multiple sclerosis and chronic progressive multiple sclerosis. Randomized, controlled trials of at least one year's duration were selected if they included only patients with PPMS or if they reported sufficient PPMS subgroup data. No restrictions with respect to intervention or comparator were applied. Study quality was assessed by a biometrics expert. Relevant baseline characteristics and outcomes were extracted and compared.Of 52 PPMS studies identified, four were selected. Inclusion criteria were notably different among studies with respect to both the definition of PPMS and the requirements for the presence of disability progression at enrolment. Differences between the study populations included the baseline lesion load, pretreatment status and disease duration. The rate of disease progression may also be an important factor, as all but one of the studies included a large proportion of patients with a low progression rate. In addition, the endpoints specified could not detect progression adequately.Optimal PPMS study methods involve appropriate patient selection, especially regarding the PPMS phenotype and progression rate. Functional composite endpoints might be more sensitive than single endpoints in capturing progression.

  2. Progress in characterizing the multidimensional color quality properties of white LED light sources

    Science.gov (United States)

    Teunissen, Kees; Hoelen, Christoph

    2016-03-01

    With the introduction of solid state light sources, the variety in emission spectra is almost unlimited. However, the set of standardized parameters to characterize a white LED light source, such as correlated color temperature (CCT) and CIE general color rendering index (Ra), is known to be limited and insufficient for describing perceived differences between light sources. Several characterization methods have been proposed over the past decades, but their contribution to perceived color quality has not always been validated. To gain more insight in the relevant characteristics of the emission spectra for specific applications, we have conducted a perception experiment to rate the attractiveness of three sets of objects, including fresh food, packaging materials and skin tones. The objects were illuminated with seven different combinations of Red, Green, Blue, Amber and White LEDs, all with the same CCT and illumination level, but with differences in Ra and color saturation. The results show that, in general, object attractiveness does not correlate well with Ra, but shows a positive correlation with saturation increase for two out of three applications. There is no clear relation between saturation and skin tone attractiveness, partly due to differences in preference between males and females. A relative gamut area index (Ga) represents the average change in saturation and a complementary color vector graphic shows the direction and magnitude of chromatic differences for the eight CIE-1974 test-color samples. Together with the CIE general color rendering index (Ra) they provide useful information for designing and optimizing application specific emission spectra.

  3. Site characterization progress report: Yucca Mountain, Nevada. Number 15, April 1--September 30, 1996

    International Nuclear Information System (INIS)

    During the second half of fiscal year 1996, activities at the Yucca Mountain Site Characterization Project (Project) supported the objectives of the revised Program Plan released this period by the Office of Civilian Radioactive Waste Management of the US Department of Energy (Department). Outlined in the revised plan is a focused, integrated program of site characterization, design, engineering, environmental, and performance assessment activities that will achieve key Program and statutory objectives. The plan will result in the development of a license application for repository construction at Yucca Mountain, if the site is found suitable. Activities this period focused on two of the three near-term objectives of the revised plan: updating in 1997 the regulatory framework for determining the suitability of the site for the proposed repository concept and providing information for a 1998 viability assessment of continuing toward the licensing of a repository. The Project has also developed a new design approach that uses the advanced conceptual design published during the last reporting period as a base for developing a design that will support the viability assessment. The initial construction phase of the Thermal Testing Facility was completed and the first phase of the in situ heater tests began on schedule. In addition, phase-one construction was completed for the first of two alcoves that will provide access to the Ghost Dance fault

  4. Site characterization progress report: Yucca Mountain, Nevada. Number 15, April 1--September 30, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    During the second half of fiscal year 1996, activities at the Yucca Mountain Site Characterization Project (Project) supported the objectives of the revised Program Plan released this period by the Office of Civilian Radioactive Waste Management of the US Department of Energy (Department). Outlined in the revised plan is a focused, integrated program of site characterization, design, engineering, environmental, and performance assessment activities that will achieve key Program and statutory objectives. The plan will result in the development of a license application for repository construction at Yucca Mountain, if the site is found suitable. Activities this period focused on two of the three near-term objectives of the revised plan: updating in 1997 the regulatory framework for determining the suitability of the site for the proposed repository concept and providing information for a 1998 viability assessment of continuing toward the licensing of a repository. The Project has also developed a new design approach that uses the advanced conceptual design published during the last reporting period as a base for developing a design that will support the viability assessment. The initial construction phase of the Thermal Testing Facility was completed and the first phase of the in situ heater tests began on schedule. In addition, phase-one construction was completed for the first of two alcoves that will provide access to the Ghost Dance fault.

  5. International vision requirements for driver licensing and disability pensions: using a milestone approach in characterization of progressive eye disease

    OpenAIRE

    Bron, Alain M.; Viswanathan, Ananth C.; Thelen, Ulrich; Natale, Renato; Ferreras, Antonio; Gundgaard, Jens; Schwartz, Gail; Buchholz, Patricia

    2010-01-01

    Objective Low vision that causes forfeiture of driver’s licenses and collection of disability pension benefits can lead to negative psychosocial and economic consequences. The purpose of this study was to review the requirements for holding a driver’s license and rules for obtaining a disability pension due to low vision. Results highlight the possibility of using a milestone approach to describe progressive eye disease. Methods Government and research reports, websites, and journal articles ...

  6. Bowdoin National Wildlife Refuge contaminant biomonitoring study: Progress report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this study was to determine the extent of trace element contamination, particularly boron and selenium, and organochlorine contamination in sediment...

  7. Tijuana River National Wildlife Refuge contaminant study: Progress report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — A contaminant study was initiated at Tijuana Slough National Wildlife Refuge in 1987, as a result of concern for pollution from a variety of potential sources. To...

  8. Combined thermodynamic study of nickel-base alloys. Progress report

    International Nuclear Information System (INIS)

    Achievements during this period are the following: (1) initiation of a high-temperature study of the Ni-Ta system using the galvanic cell technique, (2) emf study of high-temperature thermodynamics in the Ni-Mo system, (3) measured heat capacity data on ordered and disordered Ni4Mo, (4) heat capacities of Ni and disordered Ni3Fe, and (5) computer correlation of thermodynamic and phase diagram data in binary Ni-base alloys

  9. Gender and career progression in theology and religious studies.

    OpenAIRE

    Guest, Mathew; Sharma, Sonya; Song, Robert

    2013-01-01

    The low proportion of women within the subject areas of Theology and Religious Studies has long been observed, and is increasingly recognised as a serious problem for staff and students. In this new study, Mathew Guest, Sonya Sharma and Robert Song chart patterns of gender imbalance among staff and students across UK TRS departments, exploring why such patterns remain so persistent. Drawing on interviews with TRS academics across the country, the report examines the professional life of femal...

  10. Stable isotope studies: Progress report, March 1985--August 1987

    International Nuclear Information System (INIS)

    Studies have been carried out in the following areas: Stable Isotope Fractionation (1) Effects of chemical poisons and surface modifiers on polycrystalline platinum electrode surfaces have been investigated with a goal to develop a new form of heterogeneous catalyst for the hydrogen isotope exchange between dihydrogen and water. (2) A new nitrogen-15 fractionation process has been developed, based on the isotope exchange between liquid N2O3-N2O4 mixture and their vapor phase at a subambient temperature and a raised pressure. (3) A closed chemical recycle process has been developed for use in connection with the refluxer in the Nitrox-type nitrogen-15 plant. Isotope Effects (1) The vapor pressure isotope effect (VPIE) study of liquid fluoromethanes have been completed. (2) The VPIE study of solid and liquid ammonia has been completed. (3) A theoretical foundation of the additivity for the vibrational zero-point energy (ZPE) has been developed. Studies of Liquid Ammonia. With an aim to study intermolecular interaction (and the inversion phenomenon, in particular) in liquid ammonia, and to further investigate various ammonia solutions, a molecular dynamics (MD) study has been initiated. An MD program has been completed, and force field functions have been developed for an ensemble of non-rigid ammonia molecules. 107 refs., 41 figs., 10 tabs

  11. Progress of the Proton-Ion Medical Machine Study (PIMMS)

    International Nuclear Information System (INIS)

    The Proton-Ion Medical Machine Study (PIMMS) was set up following an agreement between Professor M. Regler of the Med-AUSTRON (Austria) and Professor U. Amaldi of the TERA Foundation (Italy) to join their efforts in the design of a medical synchrotron that could later be adapted to individual national needs. CERN agreed to host this study inside its PS Division and to contribute one full-time member to the study team. The study group has worked in collaboration with GSI (Germany) and was more recently joined by Onkologie 2000 (Czech Republic). Work started in January 1996 and is expected to finish during 1998. The agreed aim of the study was to investigate and design a generic facility that would allow the direct clinical comparison of protons and carbon ions for cancer treatment. The accelerator was to be designed primarily for high-precision active beam scanning with both protons and ions, but was also to be capable of delivering proton beams with passive spreading. (orig.)

  12. Design, synthesis, characterization and study of novel conjugated polymers

    Energy Technology Data Exchange (ETDEWEB)

    Chen, W.

    1997-06-24

    After introducing the subject of conjugated polymers, the thesis has three sections each containing a literature survey, results and discussion, conclusions, and experimental methods on the following: synthesis, characterization of electroluminescent polymers containing conjugated aryl, olefinic, thiophene and acetylenic units and their studies for use in light-emitting diodes; synthesis, characterization and study of conjugated polymers containing silole unit in the main chain; and synthesis, characterization and study of silicon-bridged and butadiene-linked polythiophenes.

  13. Seismic-reflection and ground penetrating radar for environmental site characterization. 1998 annual progress report

    International Nuclear Information System (INIS)

    'The project''s goals are threefold: (1) to examine the complementary site-characterization capabilities of modern, three-component shallow-seismic techniques and ground-penetrating radar (GPR) methods at depths ranging from 2 to 8 m at an existing test site; (2) to demonstrate the usefulness of the two methods when used in concert to characterize, in three-dimensions, the cone of depression of a pumping well, which will serve as a proxy site for fluid-flow at an actual, polluted site; and (3) to use the site as an outdoor mesoscale laboratory to validate existing three-dimensional ground-penetrating radar and seismic-reflection computer models developed at the Univ. of Kansas. To do this, useful seismic and GPR data are being collected along the same line(s) and within the same depth range. The principal investigators selected a site in central Kansas as a primary location and, although the site itself is not environmentally sensitive, the location chosen offers particularly useful attributes for this research and will serve as a proxy site for areas that are contaminated. As part of an effort to evaluate the strengths of each method, the authors will repeat the seismic and GPR surveys on a seasonal basis to establish how the complementary information obtained varies over time. Because the water table fluctuates at this site on a seasonal basis, variations in the two types of data over time also can be observed. Such noninvasive in-situ methods of identifying and characterizing the hydrologic flow regimes at contaminated sites support the prospect of developing effective, cost-conscious cleanup strategies in the near future. As of the end of May 1998, the project is on schedule. The first field work was conducted using both of the geophysical survey methods in October of 1997, and the second field survey employed both methods in March of 1998. One of the stated tasks is to reoccupy the same survey line on a quarterly basis for two years to examine change in both

  14. Recent progresses of polymer crystallization studied by AFM

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The crystallization of polymers has been one of the major topics in polymer physics. Spherulites are common crystalline structures observed in semi-crystalline polymers. Many studies[1-5] have been performed to investigate the detailed structures and formation mechanisms. It is generally accepted that the three-dimensional geometry of spherulites develops from a stack of lamellae.

  15. The progress in the study of Arctic pack ice ecology

    Institute of Scientific and Technical Information of China (English)

    何剑锋; 王桂忠; 蔡明红; 李少菁

    2004-01-01

    The sea ice community plays an important role in the Arctic marine ecosystem. Because of the predicted environmental changes in the Arctic environment and specifically related to sea ice, the Arctic pack ice biota has received more attention in recent years using modern ice-breaking research vessels. Studies show that the Arctic pack ice contains a diverse biota and besides ice algae, the bacterial and protozoan biomasses can be high. Surprisingly high primary production values were observed in the pack ice of the central Arctic Ocean. Occasionally biomass maximum were discovered in the interior of the ice floes, a habitat that had been ignored in most Arctic studies. Many scientific questions, which deserve special attention, remained unsolved due to logistic limitations and the sea ice characteristics. Little is know about the pack ice community in the central Arctic Ocean. Almost no data exists from the pack ice zone for the winter season. Concerning the abundance of bacteria and protozoa, more studies are needed to understand the microbial network within the ice and its role in material and energy flows. The response of the sea ice biota to global change will impact the entire Arctic marine ecosystem and a long-term monitoring program is needed. The techniques, that are applied to study the sea ice biota and the sea ice ecology, should be improved.

  16. Parameter estimates for invasive breast cancer progression in the Canadian National Breast Screening Study

    OpenAIRE

    Taghipour, S.; Banjevic, D; Miller, A.B.; Montgomery, N; A K S Jardine; Harvey, B. J.

    2013-01-01

    Background: The aim of screening is to detect a cancer in the preclinical state. However, a false-positive or a false-negative test result is a real possibility. Methods: We describe invasive breast cancer progression in the Canadian National Breast Screening Study and construct progression models with and without covariates. The effect of risk factors on transition intensities and false-negative probability is investigated. We estimate the transition rates, the sojourn time and sensitivity o...

  17. Molecular orbitual studies of the bonding in heavy element organometallics: Progress report

    International Nuclear Information System (INIS)

    Progress to date is described in 2 major areas: (1) Tris(cyclopentadienyl) actinide complexes. We have made considerable progress in our studies of the electronic structure of organoactinide compounds containing three cyclopentadienyl ligands: investigations of the ''base-free'' compounds Cp3An, and investigations of the interaction of Cp3An compounds with a fourth ligand, L. (2) Actinide-containing molecules with metal-metal bonds, actinide-actinide bonds, and actinide-transition metal bonds

  18. Progress in study on microbe-metallogenesis of uranium

    International Nuclear Information System (INIS)

    Results of experimental studies for microbial uranium accumulation by anaerobic and aerobic bacteria, as well as mechanisms and developing tendency of microbial uranium accumulation are discussed in the present paper. Up to now, the study on microbe-metallogenesis of uranium has been at an experimental stage in laboratory. Mechanisms of microbial uranium accumulation are divided into two types: those that are metabolism-dependent and those that are metabolism-independent. Metabolism-dependent uranium accumulation consists of extracellular precipitation with metabolically produced ligands, complexation arising from excreted metabolites, or precipitation due to enzyme-mediated changes in reduction state. Metabolism-dependent accumulation can also involve active pumping of metals, leading to intracellular accumulation. Metabolism-independent accumulation involves a physio-chemical interaction between cationic uranium species and negatively charged sites in microorganisms, and can occur whether cells are living or non-living (even in cell wall fragments)

  19. Radioactivity studies. Progress report, April 30, 1984-June 1, 1985

    International Nuclear Information System (INIS)

    This report includes information pertaining to metabolic studies of neptunium and protactinium in the adult baboon. Recent investigations have provided additional data on the uptake, distribution, retention and excretion of Np-237, Np-239 and Pa-233 in baboons following single intravenous and gavage administrations. Data is also presented on the gastrointestinal absorption of isotopes of uranium, neptunium and plutonium in individual baboons after receiving multiple gavage administrations at selected time intervals and nutritional states. The gastrointestinal (GI) absorption (f1 values) and retention factors have been calculated for each of these nuclides. We have begun metabolic studies on the adult tamarin (Saquinis labiatus). Data are presented in this report on the preliminary results of the metabolism of Np-239 bicarbonate intravenously injected into three females and one male tamarin. These data are discussed in comparison with similar results obtained with our baboons and with other species. 28 refs., 20 figs., 14 tabs

  20. Progress in Low and Intermediate Level Operational Waste Characterization and Preparation for Disposal at Ignalina NPP

    Energy Technology Data Exchange (ETDEWEB)

    Poskas, P.; Adomaitis, J. E.; Ragaisis, V.

    2003-02-25

    In Lithuania about 70-80% of all electricity is generated at a single power station, Ignalina NPP, which has two RBMK-1500 type reactors. Units 1 and 2 will be closed by 2005 and 2010, respectively, taking into account the conditions of the long-term substantial financial assistance rendered by the European Union, G-7 countries and other states as well as international institutions. The Government approved the Strategy on Radioactive Waste Management. Objectives of this strategy are to develop the radioactive waste management infrastructure based on modern technologies and provide for the set of practical actions that shall bring management of radioactive waste in Lithuania in compliance with radioactive waste management principles of IAEA and with good practices in force in European Union Member States. SKB-SWECO International-Westinghouse Atom Joint Venture with participation of Lithuanian Energy Institute has prepared a reference design of a near surface repository for short-lived low and intermediate level waste. This reference design is applicable to the needs in Lithuania, considering its hydro-geological, climatic and other environmental conditions and is able to cover the expected needs in Lithuania for at least thirty years ahead. Development of waste acceptance criteria is in practice an iterative process concerning characterization of existing waste, repository development, safety and environmental impact assessment etc. This paper describes the position in Lithuania with regard to the long-term management of low and intermediate level waste in the absence of finalized waste acceptance criteria and a near surface repository.

  1. Progress in Low and Intermediate Level Operational Waste Characterization and Preparation for Disposal at Ignalina NPP

    International Nuclear Information System (INIS)

    In Lithuania about 70-80% of all electricity is generated at a single power station, Ignalina NPP, which has two RBMK-1500 type reactors. Units 1 and 2 will be closed by 2005 and 2010, respectively, taking into account the conditions of the long-term substantial financial assistance rendered by the European Union, G-7 countries and other states as well as international institutions. The Government approved the Strategy on Radioactive Waste Management. Objectives of this strategy are to develop the radioactive waste management infrastructure based on modern technologies and provide for the set of practical actions that shall bring management of radioactive waste in Lithuania in compliance with radioactive waste management principles of IAEA and with good practices in force in European Union Member States. SKB-SWECO International-Westinghouse Atom Joint Venture with participation of Lithuanian Energy Institute has prepared a reference design of a near surface repository for short-lived low and intermediate level waste. This reference design is applicable to the needs in Lithuania, considering its hydro-geological, climatic and other environmental conditions and is able to cover the expected needs in Lithuania for at least thirty years ahead. Development of waste acceptance criteria is in practice an iterative process concerning characterization of existing waste, repository development, safety and environmental impact assessment etc. This paper describes the position in Lithuania with regard to the long-term management of low and intermediate level waste in the absence of finalized waste acceptance criteria and a near surface repository

  2. Purification and characterization of smectite clay taken from Gafsa, Tunisia: Progressive elimination of carbonates

    International Nuclear Information System (INIS)

    This work shows the results of various analysis on a representative clay sample from southern west of Tunisia, particularly from Oued Tfal near the town of Gafsa. The raw smectite contains some carbonate, quartz, chlorite, and anorthite. During the attack of the carbonate clay with a solution of hydrochloric acid, a change of the chemical composition and physical properties was observed. This change is dependent on several factors: the initial concentration of the acid, the nature of the clay, the ratio acid / clay...). Although treatment to 0.5 M represents a total removal of carbonates, there are probably altered layers of the clay fraction. The result shows that for a treatment with acid solutions of concentrations below 0.5 M there is gradual removal of carbonate without protonation of the clay layers. The characterization of the clay fraction shows that the sodium clay purified (OTNa) consists of a sodium montmorillonite smectite. The cation exchange capacity and the specific surface of OTNa measured using the method of methylene blue are equal to 82 meq/100g and 667 m2 / g respectively.

  3. Progress of marine biodiversity studies in China seas

    OpenAIRE

    Ruiyu Liu

    2011-01-01

    Efforts have been made by scientists studying on the taxonomy, biogeography and biodiversity in China seas since 1950, the establishment of Qingdao Marine Biological Laboratory, Chinese Academy of Sciences (CAS). Over 1,000 papers and 200 volumes of monographs have been published, of which more than 47 volumes are Fauna Sinica ― Invertebrata (27 volumes on marine biota), 11 volumes of Fauna Sinica ― Vertebrata are on fishes, and 8 volumes are Flora Algarum Marinarum Sinicarum. Results of stud...

  4. Biophysical studies related to energy generation: Eighteen year progress report

    International Nuclear Information System (INIS)

    Research accomplishments are briefly summarized. These include the successful transfer of the detailed atomic cross section approach from aeronomy to radiological physics, the application of analytic shell and optical model electron-atom potentials to estimations of electronic excitation and ionization cross sections for radiological applications, the use of two dimensional yield spectra to applied energy degradation studies, research into energy-atmospheric environments, and work on connecting gaseous and liquid phase electron energy loss measures. A list of publications is included

  5. Progress in Fast Ignition Studies with Electrons and Protons

    International Nuclear Information System (INIS)

    Isochoric heating of inertially confined fusion plasmas by laser driven MeV electrons or protons is an area of great topical interest in the inertial confinement fusion community, particularly with respect to the fast ignition (FI) concept for initiating burn in a fusion capsule. In order to investigate critical aspects needed for a FI point design, experiments were performed to study 1) laser-to-electrons or protons conversion issues and 2) laser-cone interactions including prepulse effects. A large suite of diagnostics was utilized to study these important parameters. Using cone--wire surrogate targets it is found that pre-pulse levels on medium scale lasers such as Titan at Lawrence Livermore National Laboratory produce long scale length plasmas that strongly effect coupling of the laser to FI relevant electrons inside cones. The cone wall thickness also affects coupling to the wire. Conversion efficiency to protons has also been measured and modeled as a function of target thickness, material. Conclusions from the proton and electron source experiments will be presented. Recent advances in modeling electron transport and innovative target designs for reducing igniter energy and increasing gain curves will also be discussed. In conclusion, a program of study will be presented based on understanding the fundamental physics of the electron or proton source relevant to FI.

  6. Radiation-damage studies for fusion reactors. Progress report

    International Nuclear Information System (INIS)

    FY 1983 has been a very productive year with respect to obtaining results and educating students in the field of Fusion Materials. We have analyzed the results of 14 MeV irradiated copper and have correlated the information with previous work done at HEDL. The 750 keV light ion accelerator has been used to preimplant samples with He as well as to study blistering in nickel. A collaborative effort with ORNL was completed on helium-irradiated Cu-Ni alloys. The effects of injected interstitials on void nucleation were studied and a theory developed to explain some past discrepancies in ion irradiated specimens. Initial ion irradiations have been performed on 316 SS and HT-9 alloys. New techniques for plating type 316 stainless steel, ferritic steels and aluminum have been developed as well as intense beams of Fe, Ti and Al for ion bombardment studies. Two new electron microscopy facilities have been installed; a JELCO-200CX with EDX capabilities a high resolution Vacuum Generator HB501 for very precise microchemical analysis

  7. Progress on qualification testing methodology study of electric cables

    International Nuclear Information System (INIS)

    By recent aging studies of electric cables during loss-of-coolant (LOCA) conditions, it was found that low dose rate irradiation gave rise to significant degradation even at room temperature. The authors conducted simultaneous LOCA tests exceeding three months at low dose rate and compared the results with a one week LOCA test at high dose rate in order to verify the above assumption. LOCA simulation with saturated steam and air containing steam were tested. Results of changes in mechanical properties and volume resistivity are reported for ethylene-propylene rubber and chlorosulfonated polyethylene insulated cables

  8. Study of transitional nuclei at TRISTAN. Progress report

    International Nuclear Information System (INIS)

    During the past calendar year the Oklahoma group has participated in decay studies on the following nuclides: 99Rb, 99Sr, 101Y, and 100Y. The resulting information on the structure of these nuclides has defined band structure for the first time in the odd-A nuclei in this region. The principal investigator also participated in a measurement of the g-factor of an excited state in 97Zr and two attempts to measure the quadrupole moment of the same state. Details of these and other activities are given

  9. Progress in cognitive neuroscientific studies of visual awareness

    Institute of Scientific and Technical Information of China (English)

    Qi Li; Haiyan Geng

    2009-01-01

    The psychological and neural mechanisms of consciousness are among the most baffling problems in cognitive neuroscience. In this field, visual awareness is a topic that has been largely investigated, due to easy manipulation and measurable effects. The present arti-cle begins with the phenomena of dissociations between visual awareness and visual stimulus, visual awareness and visual attention, as well as visual awareness and vision-guided behavior, along with the corresponding experimental evidence. Furthermore, the neural mechanism of visual awareness is also discussed. It has been generally believed that visual awareness is the function of higher-order cerebral areas; however, recent discoveries have demonstrated that feedback from higher- to lower-order cortex areas is necessary for generating consciousness. The present article presents an in-depth analysis regarding this feedback process, and exploring its relation-ship with the generation and mechanisms of consciousness. Finally, theoretical controversies and discrepancies, as well as result con-flicts from various studies, have been collected, compared and discussed. Because the field of consciousness continues to be an extremely mysterious and complicated psychological phenomenon, there is a great need for further studies to explore and clarify this topic.

  10. Biophysical studies related to energy generation. Progress report

    International Nuclear Information System (INIS)

    We are connecting our work on spatial and spectral yields with the subsequent diffusion and radiation chemistry of the initial production of electron energy deposition. The intent is to develop the spatial plumes of atoms, molecules, and free radicals surrounding incident electrons of various energies. Once this is achieved it should be possible to convolute the secondary electron distributions arising from various primary particles such as protons or heavy ions to obtain the distribution of chemical species surrounding the track of the primary particles. This would constitute a direct physical route for connecting the radiation physics with radiation chemistry. To bridge the gap between the physical and chemical phase of radiation action we are utilizing numerical techniques developed in studies of flames and rocket plumes

  11. Progress of studies on supernova explosions and r-process

    International Nuclear Information System (INIS)

    Observational data of r-process elements in extremely metal-poor stars have strong impacts on understanding the origin of heavy elements. Recent increase of observational data further clarifies that the abundance pattern of r-process elements is universal, but in a limited region of the periodic table. This suggests that there are more than one sites for r-process in supernova explosions. We show that the two scenarios of r-process in prompt explosions and neutrino-driven winds in supernovae are viable. These scenarios may correspond to explosion mechanisms (prompt explosion and delayed explosion) depending on the mass of presupernova stars. We found that r-process in neutrino-driven winds depends on the physical conditions of the outer region of the wind between proto-neutron star surface and shockwave. This implies the importance of quantitative study of the explosion mechanism via detailed numerical simulations with microphysics such as nuclear and neutrino physics. (author)

  12. Performing Inquisitive Study of PM Traits Desirable for Project Progress

    Directory of Open Access Journals (Sweden)

    Sobia Zahra

    2014-02-01

    Full Text Available The accountability of a project’s success/failure lies on shoulders of a PM (project manager. Undoubtedly, project management is tough task to bring about and this is the most challenging role within the project. The project manager role varies from project to project and may include communication & negotiation with stakeholders, along with leadership and management of the project. Therefore he must possess both hard and soft skills besides education and expertise to drive his team towards excellence. This scientific documentation presents an ideal blend of responsibilities and skills essential for a project manager to cope with the changing project environment. Technical skills necessary for an IT project manager, further elaborates this study.

  13. Progress with volunteer studies of nasal deposition and clearance

    International Nuclear Information System (INIS)

    Inhalation is the main route of intake of radioactive material for workers, and can be an important pathway for members of the public following accidental releases of radioactivity to the environment. Much of the inhaled radioactivity initially deposits in the nose, typically over 40% for particles of aerodynamic diameter (dae) greater than 2 μm. However, there is remarkably little information on the clearance from the human nose of particles deposited during inhalation and, until now, none on the clearance of the significant fraction of material that remains in the nasal passage for more than 12 hours. NRPB is conducting a volunteer study to determine the effects of particle size and breathing pattern on particle deposition in, and clearance from, the human nasal passage. This article summarises results obtained to date. (author)

  14. Study of atmospheric pollution scavenging. Sixteenth progress report

    Energy Technology Data Exchange (ETDEWEB)

    Semonin, R.G.; Gatz, D.F.; Peden, M.E.; Stensland, G.J.

    1978-07-01

    The relative spatial variability of atmospheric deposition was studied for sampling networks of various areas in the U.S., Sweden, and the U.S.S.R. The data were derived from event, monthly, and yearly sample collection periods. The results indicate the relative variability for precipitation, chemical concentration of constituents, and the deposition increase in that order. A factor analysis approach to interpretation of the role of aerosol in altering rainfall is presented. The results indicate that either aerosol does not influence rainfall amount, or a critical chemical component of the aerosol was not included in the analysis. Careful analyses were carried out, comparing historical and current precipitation chemistry at Champaign-Urbana. The results show that the apparent high pH values of rainfall in 1954 were due to high values of calcium and magnesium and not due to low concentrations of sulfate and nitrogen species. New field efforts were initiated in 1978 in east-central Illinois to measure rain chemistry with improved precision over previous effort. The preliminary results from the first light rainshower show some puzzling relationships between the amount of rain and various chemical concentrations. The pH appears to be inversely related to rain volume, but other ionic species are not so easily identified with rain amount. The summer field experiment has, thus far, produced approximately 12 additional events which are in various stages of analysis. The study of the stability of ions in precipitation was continued and is the subject of additional proposed work. The results are very firm at this time, that either wet-only sampling must be carried out, or the sample must be preserved at 4/sup 0/C to retain the chemical integrity of the sample. It is recommended, however, that filtration of the sample be accomplished within 12 hours of the cessation of precipitation to ensure stability of the ionic composition.

  15. Idaho Steelhead Monitoring and Evaluation Studies : Annual Progress Report 2007.

    Energy Technology Data Exchange (ETDEWEB)

    Copeland, Timothy; Putnam, Scott

    2008-12-01

    The goal of Idaho Steelhead Monitoring and Evaluation Studies is to collect monitoring data to evaluate wild and natural steelhead populations in the Clearwater and Salmon river drainages. During 2007, intensive population data were collected in Fish Creek (Lochsa River tributary) and Rapid River (Little Salmon River tributary); extensive data were collected in other selected spawning tributaries. Weirs were operated in Fish Creek and Rapid River to estimate adult escapement and to collect samples for age determination and genetic analysis. Snorkel surveys were conducted in Fish Creek, Rapid River, and Boulder Creek (Little Salmon River tributary) to estimate parr density. Screw traps were operated in Fish Creek, Rapid River, Secesh River, and Big Creek to estimate juvenile emigrant abundance, to tag fish for survival estimation, and to collect samples for age determination and genetic analysis. The estimated wild adult steelhead escapement in Fish Creek was 81 fish and in Rapid River was 32 fish. We estimate that juvenile emigration was 24,127 fish from Fish Creek; 5,632 fish from Rapid River; and 43,674 fish from Big Creek. The Secesh trap was pulled for an extended period due to wildfires, so we did not estimate emigrant abundance for that location. In cooperation with Idaho Supplementation Studies, trap tenders PIT tagged 25,618 steelhead juveniles at 18 screw trap sites in the Clearwater and Salmon river drainages. To estimate age composition, 143 adult steelhead and 5,082 juvenile steelhead scale samples were collected. At the time of this report, 114 adult and 1,642 juvenile samples have been aged. Project personnel collected genetic samples from 122 adults and 839 juveniles. We sent 678 genetic samples to the IDFG Eagle Fish Genetics Laboratory for analysis. Water temperature was recorded at 37 locations in the Clearwater and Salmon river drainages.

  16. Comprehensive study of psi meson production. Progress report

    International Nuclear Information System (INIS)

    Our first paper under this grant is a calculation of prompt lepton production in upsilon and toponium decay. The results should prove useful in identifying signals for charm or bottom production. Our work has led to some improvement in our understanding of psi production in hadronic interactions, although further work is needed. Attempts to explain the difference between experimental and theoretical rates of psi hadroproduction led to a study of quark-gluon scattering, which proved to have a negative impact on the theoretical cross section once a leading mass singularity was absorbed into the gluon distribution function. Our study of psi production in B meson decays has led to an improvement in the leading-log calculation of this rate, which gives a much more precise prediction of the decay rate. We have also calculated all first-order QCD corrections to this weak process. We are now completing a companion calculation of n/sub c/ production, for which there is presently no data. Dr. Harms and Dr. Cox have collaborated on an attempt to determine the dominant contribution to the difference sigma(pN → psi x) - sigma(anti pN → psi x). The lowest order process contributing to this difference (q anti q → psi GG) has been shown previously to be small. They have calculated the next order process (q anti q → G*G* → psi G) and have apparently uncovered a new example of the violation of the Bloch-Nordsieck mechanism in QCD. Our work outside the realm of QCD has included a new fit to the total pp and anti pp cross sections. Dr. Cox has also been pursuing the question of representations of extended (especially N=8) supersymmetry

  17. Accelerator research studies: Technical progress report, June 1, 1988--May 31, 1989

    International Nuclear Information System (INIS)

    This report discusses research progress in the following general topics: Study of transport and longitudinal compression of intense, high-brightness beams; study of collective ion acceleration by intense electron beams and pulse powered plasma focus; and study of microwave sources and parameter scaling for high-frequency electron-positron supercollider linacs

  18. PROGRESS IN STUDIES ON ICE ACCUMULATION IN RIVER BENDS

    Institute of Scientific and Technical Information of China (English)

    WANG Jun; CHEN Pang-pang; SUI Jue-yi

    2011-01-01

    River ice is an important hydraulic element in temperate and polar environments and would affect hydrodynamic conditions of rivers through changes both in the boundary conditions and the thermal regime.The river bend has been reported as the common location for the initiation of ice jams because the water flow along a river bend is markedly affected by the channel curvature.In this article,the experimental studies about the ice accumulation in a river bend are reviewed.Based on experiments conducted so far,the criteria for the formation of ice jams in the river bend,the mechanisms of the ice accumulation in the river bend and the thickness profile of the ice accumulation in the river bend are discussed.The k- ε two-equation turbulence model is used to simulate the ice accumulation under an ice cover along a river bend.A formula is proposed for describing the deformation of the ice jam bottom.Our results indicate that all simulated thickness of the ice accumulation agrees reasonably well with the measured thickness of the ice accumulation in the laboratory.

  19. A progress report of the Marshall Islands nationwide thyroid study: an international cooperative scientific study.

    Science.gov (United States)

    Takahashi, T; Simon, S L; Trott, K R; Fujimori, K; Nakashima, N; Arisawa, K; Schoemaker, M J

    1999-04-01

    The objective of this report is to present a summary of progress of the Marshall Islands Nationwide Thyroid Study. As well known, the US atomic weapons testing program in the Pacific was conducted primarily between 1946 and 1958 in the Marshall Islands. The nuclear tests resulted in radioactive contamination of a number of atolls and resulted in exposure of Marshallese to undefined levels before our study. Little information has been paid to health consequences among residents of the nearly twenty inhibited atolls except for some information about nodular thyroid disease which was reported on by an US group. In a cooperative agreement with the Government of the Marshall Islands, between 1993 and 1997 we studied the prevalence of both thyroid nodules and thyroid cancer among 4766 Marshallese potentially exposed to radioiodines from bomb test fallout. That group represents more than 65% of the population at risk. We diagnosed 45 thyroid cancers and 1398 benign thyroid nodules. In addition, 23 study participants had been operated on prior to our study for thyroid cancer. Presently, we are developing a database of information to estimate radiation doses and planning a statistical analysis to determine if a dose-response relationship exists. These data will be important for the health promotion of exposed people all over the world including Hiroshima, Nagasaki, Semipalatinsk, Chernobyl and other locations. A timely completion is important for purpose of assisting Marshallese as well as to add the global understanding of radiation induced thyroid cancer. PMID:10503608

  20. Progressive multifocal leuko-encephalopathy studied by magnetization transfer imaging; Leucoencephalopathie multifocale progressive. Etude de la demyelinisation par transfert de magnetisation

    Energy Technology Data Exchange (ETDEWEB)

    Armand, J.P.; Dousset, V.; Mieze, S.; Caille, J.M. [Hopital Pellegrin, 33 - Bordeaux (France); Franconi, J.M. [Siemens SA, 92 - Saint-Denis (France). Service Instrumentation Scientifique; Lacoste, D. [Gecsa, Groupe d`Epidemiologie Clinique du Sida en Aquitaine, CHU, 33 - Bordeaux (France); Letenneur, L. [Bordeaux-2 Univ., 33 (France)

    1997-09-01

    Purpose: magnetization transfer imaging (MT) has bees used to study the degree of demyelination in progressive multifocal leuko-encephalopathy (PML). Material and method: two groups were studied: a group of 10 HIV + patients with clinical, MR features, biological and/or biopsy proven PLM, and a group of 11 normal volunteers with matched age. MT ratio (MTR) were obtained from the center of the PLM lesions and 11 areas of normal appearing white matter (NAWM) in the control group. Results: the mean MTR of NAWM in the control group was 46.6% (SD = 2,3). PLM lesions demonstrated a strong and significant (p = 0) decreased of the MTR with mean MTR value of 22.4% (SD = 2,3). Conclusion: MT characterized the demyelinating process in PLM, and can be to used to improve diagnosis. Furthermore, MT allowed a quantification of the degree of the demyelination which can be helpful in other demyelinating process of CNS such multiple sclerosis. (authors). 11 refs.

  1. Inflow Characterization for Marine and Hydrokinetic Energy Devices. FY-2010 Annual Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Richmond, Marshall C.; Durgesh, Vibhav; Thomson, Jim; Polagye, Brian

    2011-01-31

    Marine and Hydro Kinetic devices (MHK) are being widely studied as a source of renewable energy. The Marrowstone Island site is a potential location for installing MHK devices because the tidal currents observed that are sufficient for power generation. In order to quantify the effects of turbulence on MHK devices and the surrounding environment at this site, a prelimi- nary fluid flow field study was conducted here by the Pacific Northwest National Lab (PNNL) in collaboration with the Applied Physics Lab at the University of Washington (APL-UW). This study entailed continuous The Acoustic Doppler Velocimetry (ADV), Acoustic Doppler Current Profiler (ADCP) and Conductivity, Temperature and Depth (CTD) measurements from May 4, 2010 to May 22, 2010, in order to obtain information about turbulence effects during different tidal conditions. The instruments used for collecting the above measurements were deployed at the Marrowstone site using a R/V Jack Robertson provided by the University of Washington (APL-UW). All the measurements were taken at the site with an average depth of 22 m below the sea surface. ADV acquired velocity data at 32 Hz sampling frequency at 4.6 m above the seabed, and ADCP acquired velocity profile data at a sampling frequency of 2 Hz, from a height of 2.6 m above the seabed to the surface with a bin resolution of 0.5 m. The ADV and ADCP measurements showed that the horizontal velocity had a turbulence intensity of 10%. Further- more, the spectral analysis from ADV measurements showed that the flow is fully turbulent with -5/3 slope in the inertial sub-range of the spectra. Moreover, the temporal-frequency analysis showed presence of ”eddies” at high frequencies. These preliminary studies provided initial flow field and site characteristics, showed the limitations of the instruments used and highlighted changes that need to be made in the experimental setup for deployment in FY-2011 studies.

  2. Theoretical studies of atomic transitions. Renewal progress report, April 1, 1994 - March 31, 1997

    International Nuclear Information System (INIS)

    With the aid of powerful workstations and our software modified for large-scale computation, considerable progress has been made during the last few years. This progress is in the form of increased accuracy for transition probability studies along with estimates of uncertainty, the study of nuclear effects on atomic properties such as hyperfine interactions and isotope shifts, the study of relativistic correlation in some large and small systems, and the extension of spline methods to regions of higher energy where multiple continuum channels are present. This paper highlights this research. The appendix lists grant related papers that appeared since 1994, papers presented at conferences, and the papers submitted

  3. Aerosol sampling and characterization for hazard evaluation. Progress report, October 1, 1977-September 30, 1978

    International Nuclear Information System (INIS)

    Measurements of the dilution of air contaminants between worker breathing zone and area air samplers were made by releasing a test fluorescent aerosol in workrooms equipped with aerosol surveillance systems. These data were used to evaluate performance and suggest improvements in design of alarming air monitor systems. In one workroom studied, average half-hour breathing zone air concentration needed to trigger alarm was found to be 960 times the maximum permissible air concentration for occupational exposure to soluble 239Pu (MPC/sub a/). It was shown that alternative monitor placement in this room could result in decreasing average triggering concentration to 354 times the MPC/sub a/. Analysis of data from impaction-autoradiographic sizing comparison studies showed average disintegration to track ratio called track efficiency factor, to be 2.7 +- 0.4

  4. Plasma characterization studies for materials processing

    Energy Technology Data Exchange (ETDEWEB)

    Pfender, E.; Heberlein, J. [Univ. of Minnesota, Minneapolis, MN (United States)

    1995-12-31

    New applications for plasma processing of materials require a more detailed understanding of the fundamental processes occurring in the processing reactors. We have developed reactors offering specific advantages for materials processing, and we are using modeling and diagnostic techniques for the characterization of these reactors. The emphasis is in part set by the interest shown by industry pursuing specific plasma processing applications. In this paper we report on the modeling of radio frequency plasma reactors for use in materials synthesis, and on the characterization of the high rate diamond deposition process using liquid precursors. In the radio frequency plasma torch model, the influence of specific design changes such as the location of the excitation coil on the enthalpy flow distribution is investigated for oxygen and air as plasma gases. The diamond deposition with liquid precursors has identified the efficient mass transport in form of liquid droplets into the boundary layer as responsible for high growth, and the chemical properties of the liquid for the film morphology.

  5. Characterization of lignin and Mn peroxidases from Phanerochaete chrysosporium. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    1991-12-31

    Long-term objectives are to elucidate the role and mechanism of the various isozymes in lignin biodegradation. Work is described on electrochemical studies on lignin and Mn peroxidases. This study was performed to investigate the structural aspects which confer the lignin and Mn peroxidases with their high reactivity. The experimentally determined redox potential of the Fe{sup 3+}/Fe{sup 2+} couple for the lignin peroxidase isozymes H1, H2, H8 and H10 are very similar, near-130 mV. The redox potential for the Mn peroxidase isozymes H3 and H4 are similar to each other ({minus}88 mV and {minus}95 mV, respectively) and are more positive than the lignin peroxidases. The higher redox potential for the Fe{sup 3+}/Fe{sup 2+} couple is consistent with the heme active site of these fungal peroxidases being more electron deficient. To investigate the accessibility of the heme active site to the substrate which is oxidized [veratryl alcohol and Mn (II)], we investigated whether these substrates had any affect on the redox potential of the heme. The E{sub m7} value for lignin and Mn peroxidases are not affected by their respective substrates, veratryl alcohol and Mn (II). These results suggest that substrates do not directly interact with the ferric heme-iron as axial ligands. This is consistent with the present model for peroxidase catalysis. Suicide inhibitor (1) and nmr studies (2) indicate that the heme-iron of horseradish peroxidase (HRP) is not fully accessible to bulky substrates occur at the periphery of the heme.

  6. Inflow Characterization for Marine and Hydrokinetic Energy Devices. FY-2011: Annual Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Richmond, Marshall C.; Durgesh, Vibhav; Thomson, Jim; Polagye, Brian

    2011-06-09

    The Pacific Northwest National Laboratory (PNNL), in collaboration with the Applied Physics Laboratory at the University of Washington (APL-UW), has carried out a detailed preliminary fluid flow field study at site selected for testing of marine and hydrokinetic turbines using Acoustic Doppler Velocimetry (ADV) measurements, Acoustic Doppler Current Profiler (ADCP) measurements, and Conductivity, Temperature and Depth (CTD) measurements. In FY-2011 these measurements were performed continuously for two weeks, in order to collect data during neap and spring tides, as well as during diurnal tidal variations.

  7. The Characterization of Psychrophilic Microorganisms and their potentially useful Cold-Active Glycosidases Final Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Brenchly, Jean E.

    2008-06-30

    Our studies of novel, cold-loving microorganisms have focused on two distinct extreme environments. The first is an ice core sample from a 120,000 year old Greenland glacier. The results of this study are particularly exciting and have been highlighted with press releases and additional coverage. The first press release in 2004 was based on our presentation at the General Meeting of the American Society for Microbiology and was augmented by coverage of our publication (Appl. Environ. Microbiol. 2005. Vol. 71:7806) in the Current Topics section of the ASM news journal, “Microbe.” Of special interest for this report was the isolation of numerous, phylogenetically distinct and potentially novel ultrasmall microorganisms. The detection and isolation of members of the ultrasmall population is significant because these cells pass through 0.2 micron pore filters that are generally used to trap microorganisms from environmental samples. Thus, analyses by other investigators that examined only cells captured on the filters would have missed a significant portion of this population. Only a few ultrasmall isolates had been obtained prior to our examination of the ice core samples. Our development of a filtration enrichment and subsequent cultivation of these organisms has added extensively to the collection of, and knowledge about, this important population in the microbial world.

  8. Reaction studies of hot silicon and germanium radicals. Progress report, February 1, 1982-July 31, 1984

    International Nuclear Information System (INIS)

    The experimental approach toward attaining the goals of this research program is briefly outlined, and the progress made in the 1982 to 1984 period is reviewed in sections entitled: (1) Recoil atom experiments, (2) Studies of thermally and photochemically generated silicon and germanium radicals, and (3) Ion-molecule reaction studies

  9. Academic and social integration and study progress in problem based learning

    NARCIS (Netherlands)

    S.E. Severiens (Sabine); H.G. Schmidt (Henk)

    2008-01-01

    textabstractThe present study explores the effects of problem-based learning (PBL) on social and academic integration and study progress. Three hundred and five first-year students from three different psychology curricula completed a questionnaire on social and academic integration. Effects of a fu

  10. Prognostic factors of progression of osteoarthritis of the knee : A systematic review of observational studies

    NARCIS (Netherlands)

    Belo, J. N.; Berger, M. Y.; Reijman, M.; Koes, B. W.; Bierma-Zeinstra, S. M. A.

    2007-01-01

    objective. To provide an overview of prognostic factors of knee osteoarthritis (OA) progression. Methods. We searched Medline and Embase up to December 2003 according to a specified search strategy (keywords for disease, location, and study design). Studies that fulfilled predefined criteria were as

  11. Characterization of Thai Amulets A PIXE Study

    International Nuclear Information System (INIS)

    The Thai amulets that created in an image of Lord Buddha meditation were made to explain the Dharma of Buddha and believed to bless every life in this world for good karma. Phra Somdej Wat Rakhang amulet is the top of the five most famous Thai amulets. There are many molds with various compositions. In this work, it was the first time that X-ray fluorescence spectrometry methods; scanning electron microscope cooperated with energy dispersive X-ray fluorescence spectrometer (SEM/EDS) and particle induced X-ray emission spectroscopy (PIXE) were carried out to analyze their compositions. Two samples were collected from different molds. Results revealed C, Ca and Si were main composition. The differences in their compositions have been used to identify and characterize for each molds

  12. Progress in the synthesis and characterization of magnetite nanoparticles with amino groups on the surface

    Energy Technology Data Exchange (ETDEWEB)

    Durdureanu-Angheluta, A.; Dascalu, A.; Fifere, A.; Coroaba, A.; Pricop, L. [Centre of Advanced Research in Bionanoconjugates and Biopolymers, ' ' Petru Poni' ' Institute of Macromolecular Chemistry of Romanian Academy, 41A Aleea Grigore Ghica Voda, 700487 Iasi (Romania); Chiriac, H. [National Institute of Research and Development in Technical Physics, 700050 Iasi (Romania); Tura, V. [Faculty of Physics, ' ' Al. I. Cuza' ' University, B-dul Carol I, no. 11, 700506 Iasi (Romania); Pinteala, M., E-mail: pinteala@icmpp.ro [Centre of Advanced Research in Bionanoconjugates and Biopolymers, ' ' Petru Poni' ' Institute of Macromolecular Chemistry of Romanian Academy, 41A Aleea Grigore Ghica Voda, 700487 Iasi (Romania); Simionescu, B.C. [Centre of Advanced Research in Bionanoconjugates and Biopolymers, ' ' Petru Poni' ' Institute of Macromolecular Chemistry of Romanian Academy, 41A Aleea Grigore Ghica Voda, 700487 Iasi (Romania); Department of Natural and Synthetic Polymers, ' ' Gh. Asachi' ' Technical University of Iasi, 73 Mangeron Blvd, 700050 Iasi (Romania)

    2012-05-15

    This manuscript deals with the synthesis of new hydrophilic magnetite particles by employing a two-step method: in the first step magnetite particles with hydrophobic shell formed in presence of oleic acid-oleylamine complex through a synthesis in mass, without solvent, in a mortar with pestle were obtained; while in the second step the hydrophobic shell was interchanged with an aminosilane monomer. The influence of the Fe{sup 2+}/Fe{sup 3+} molar ratio on the dimension of the particles of high importance for their potential applications was carefully investigated. This paper, also presents an alternative method of synthesis of new core-shell magnetite particles and the complete study of their structure and morphology by FT-IR, XPS, TGA, ESEM and TEM techniques. The rheological properties and magnetization analysis of high importance for magnetic particles were also investigated. - Highlights: Black-Right-Pointing-Pointer Magnetite particles are superparamagnetic materials. Black-Right-Pointing-Pointer Magnetite has significant role in nanotechnology due to surface properties and applicability in physical and chemical processes. Black-Right-Pointing-Pointer We used an ecological method of synthesis, a reaction in mass, without solvent, in a mortar with pestle. Black-Right-Pointing-Pointer We prepared hydrophilic magnetite particles, precursors for biomedical applications.

  13. Progress in the synthesis and characterization of magnetite nanoparticles with amino groups on the surface

    International Nuclear Information System (INIS)

    This manuscript deals with the synthesis of new hydrophilic magnetite particles by employing a two-step method: in the first step magnetite particles with hydrophobic shell formed in presence of oleic acid–oleylamine complex through a synthesis in mass, without solvent, in a mortar with pestle were obtained; while in the second step the hydrophobic shell was interchanged with an aminosilane monomer. The influence of the Fe2+/Fe3+ molar ratio on the dimension of the particles of high importance for their potential applications was carefully investigated. This paper, also presents an alternative method of synthesis of new core-shell magnetite particles and the complete study of their structure and morphology by FT-IR, XPS, TGA, ESEM and TEM techniques. The rheological properties and magnetization analysis of high importance for magnetic particles were also investigated. - Highlights: ► Magnetite particles are superparamagnetic materials. ► Magnetite has significant role in nanotechnology due to surface properties and applicability in physical and chemical processes. ► We used an ecological method of synthesis, a reaction in mass, without solvent, in a mortar with pestle. ► We prepared hydrophilic magnetite particles, precursors for biomedical applications.

  14. Progress in characterizing submonolayer island growth: Capture-zone distributions, growth exponents, & hot precursors

    Science.gov (United States)

    Einstein, Theodore L.; Pimpinelli, Alberto; González, Diego Luis; Morales-Cifuentes, Josue R.

    2015-09-01

    In studies of epitaxial growth, analysis of the distribution of the areas of capture zones (i.e. proximity polygons or Voronoi tessellations with respect to island centers) is often the best way to extract the critical nucleus size i. For non-random nucleation the normalized areas s of these Voronoi cells are well described by the generalized Wigner distribution (GWD) Pβ(s) = asβ exp(-bs2), particularly in the central region 0.5 DLA). Since simulations generate orders of magnitude more data than experiments, they permit close examination of the tails of the distribution, which differ from the simple GWD form. One refinement is based on a fragmentation model. We also compare island-size distributions. We compare analysis by island-size distribution and by scaling of island density with flux. Modifications appear for attach-limited aggregation (ALA). We focus on the experimental system para-hexaphenyl on amorphous mica, comparing the results of the three analysis techniques and reconciling their results via a novel model of hot precursors based on rate equations, pointing out the existence of intermediate scaling regimes between DLA and ALA.

  15. Editorial Summary: Findings from a Survey on the Danish Study Progress Reform

    DEFF Research Database (Denmark)

    Sarauw, Laura Louise; Madsen, Simon Ryberg

    The summary presents the key findings from the first comprehensive survey of what students expect of the Danish Study Progress Reform. The summarised report is based on a survey conducted among 4.354 university students, who were asked to assess how they expect to manage their time and prioritise...... their activities in light of the Study Progress Reform’s requirements for faster completion. The survey was distributed in April 2015 as part of a politically independent research project funded by the Danish Council for Independent Research/Humanities (FKK)....

  16. Joint inversion of geophysical data for site characterization and restoration monitoring. FY97 annual progress report for EMSP

    International Nuclear Information System (INIS)

    'The purpose of this project is to develop a computer code for joint in-version of seismic and electrical data, to improve underground imaging for site characterization and remediation monitoring. The computer code developed in this project will invert geophysical data to obtain direct estimates of porosity and saturation underground, rather than inverting for seismic velocity and electrical resistivity or other geophysical properties. This is intended to be a significant improvement in the state-of-the-art of under-ground imaging, since interpretation of data collected at a contaminated site would become much less subjective. The schedule of this project is as follows: In the first year, investigators perform laboratory measurements of elastic and electrical properties of sand-clay mixtures containing various fluids. Investigators also develop methods of relating measurable geophysical properties to porosity and saturation by using rock physics theories, geostatistical, and empirical techniques together with available laboratory measurements. In the second year, investigators finish any necessary laboratory measurements and apply the methods developed in the first year to invert available borehole log data to predict measured properties of cores and sediments from a borehole. Investigators refine the inversion code in the third year and carry out a field experiment to collect seismic and electrical data. Investigators then use the inversion code to invert the field data to produce estimates of porosity and saturation in the field area where the data were collected. This report describes progress made in the first year of this three-year project.'

  17. Markers, Cofactors and Staging Systems in the Study of HIV Disease Progression: A Review

    Directory of Open Access Journals (Sweden)

    MC Portela

    1997-07-01

    Full Text Available This paper is aimed at providing a comprehensive review of markers, cofactors and staging systems used for HIV disease, focusing on some aspects that nowadays could even be considered historical, and advancing in current issues such as the prognostic value of viral load measurements, viral genotypic and phenotypic characterization, and new HIV disease treatment protocols. CD4+ cell values, combined with the new viral markers mentioned are promising as a parsimonious predictor set for defining both severity and progression. An adequate predictor of patient resource use for planning purposes still needs to be defined

  18. Characterization and stability studies of titanium beryllides

    International Nuclear Information System (INIS)

    Beryllides appear as potential candidates to replace Be in future fusion power plants due to their improved properties. However, while the fabrication and properties of beryllium are well established a lack of knowledge still exists for beryllides. In this work, we present a detailed characterization of titanium beryllides, provided by JAERI in the frame of the IEA agreement, using a large number of techniques. Compositions of Be-5 at% Ti and Be-7 at% Ti were used to produce the samples. High resolution X-ray diffraction clearly shows the formation of Be1Ti phase for the Be-7 at% Ti composition. For the Be-5 at% Ti, the major phase is Be12Ti with traces of a Be-rich phase. In both cases, no evidence was found for the presence of pure Be phase in the samples. Ti elemental maps obtained with a scanning nuclear microprobe reveals the presence of regions containing large amounts of Cr, Mn, Fe, Ni, Cu and in some cases U. These impurities are common in Be and this behaviour suggests that a segregation process occurs during the beryllide formation. Moreover, the RBS spectra also show the presence of oxygen in this region while it seems to be depleted from the beryllide bulk. The oxidation seems to occur preferentially along the beryllide boundaries and Ti depleted region

  19. International vision requirements for driver licensing and disability pensions: using a milestone approach in characterization of progressive eye disease

    Directory of Open Access Journals (Sweden)

    Alain M Bron

    2010-11-01

    Full Text Available Alain M Bron1, Ananth C Viswanathan2, Ulrich Thelen3, Renato de Natale4, Antonio Ferreras5, Jens Gundgaard6, Gail Schwartz7, Patricia Buchholz81Department of Ophthalmology, University Hospital, Dijon, France; 2Glaucoma Research Unit, Moorfields Eye Hospital NHS Foundation Trust and Department of Genetics, University College of London Institute of Ophthalmology, London, UK; 3Private Practice, Munster, Germany; 4Ospedale Civile di Monselice, Monselice, Italy; 5Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain; 6COWI, Kolding, Denmark; 7Wilmer Eye Institute, Johns Hopkins University, Glaucoma Consultants, Baltimore, MD, USA; 8Patricia Buchholz Consulting, Karlsruhe, GermanyObjective: Low vision that causes forfeiture of driver’s licenses and collection of disability pension benefits can lead to negative psychosocial and economic consequences. The purpose of this study was to review the requirements for holding a driver’s license and rules for obtaining a disability pension due to low vision. Results highlight the possibility of using a milestone approach to describe progressive eye disease.Methods: Government and research reports, websites, and journal articles were evaluated to review rules and requirements in Germany, Spain, Italy, France, the UK, and the US.Results: Visual acuity limits are present in all driver’s license regulations. In most countries, the visual acuity limit is 0.5. Visual field limits are included in some driver’s license regulations. In Europe, binocular visual field requirements typically follow the European Union standard of ≥120°. In the US, the visual field requirements are typically between 110° and 140°. Some countries distinguish between being partially sighted and blind in the definition of legal blindness, and in others there is only one limit.Conclusions: Loss of driving privileges could be used as a milestone to monitor progressive eye disease. Forfeiture could be standardized as a

  20. Site characterization progress report: Yucca Mountain, Nevada, April 1, 1991--September 30, 1991, Number 5; Nuclear Waste Policy Act (Section 113)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-06-01

    The Site Characterization Progress Report of Yucca Mountain (PR) presents brief summaries of the status of site characterization activities and cites the technical reports and research products that provide more detailed information on the activities. The report provides highlights of work started during the reporting period, work in progress, and work completed and documented during the reporting period. In addition, the report is the vehicle for the discussion of changes to the DOE`s site characterization program resulting from ongoing collection and evaluation of site information; the development of repository and waste-package designs; the results of performance assessments; and any changes that occur in response to external comments. Information covered includes geochemistry, hydrology, geology, climate, and radiation dose estimate calculations.

  1. Characterization of flaws in a tube bundle mock-up for reliability studies

    Energy Technology Data Exchange (ETDEWEB)

    Kupperman, D.S.; Bakhtiari, S. [Argonne National Lab., IL (United States)

    1997-02-01

    As part of an assessment of in-service inspection of steam generator tubes, the authors will assemble a steam generator mock-up for round robin studies and use as a test bed in evaluating emerging technologies. Progress is reported on the characterization of flaws that will be part of the mock-up. Eddy current and ultrasonic techniques are being evaluated as a means to characterize the flaws in the mock-up tubes before final assembly. Twenty Inconel 600 tubes with laboratory-grown cracks, typical of those to be used in the mock-up, were provided by Pacific Northwest National Laboratory for laboratory testing. After the tubes were inspected with eddy current and ultrasonic techniques, they were destructively analyzed to establish the actual depths, lengths, and profiles of the cracks. The analysis of the results will allow the best techniques to be used for characterizing the flaws in the mock-up tubes.

  2. Site characterization studies for the Iranian National Observatory

    OpenAIRE

    Khosroshahi, Habib G.

    2011-01-01

    We report on the Iranian National Observatory (INO) ongoing site characterization studies for INO 3.4m optical telescope under development. Iran benefits from high altitude mountains and a relatively dry climate, thus offer many suitable sites for optical observations. The site selection (2001-2007) studies resulted in two promising sites in central Iran, one of which will host the 3.4m telescope. The studies between 2008 and 2010 aimed at detail characterization of the two sites. This involv...

  3. The effect of conditional probability of chord progression on brain response: an MEG study.

    Directory of Open Access Journals (Sweden)

    Seung-Goo Kim

    Full Text Available BACKGROUND: Recent electrophysiological and neuroimaging studies have explored how and where musical syntax in Western music is processed in the human brain. An inappropriate chord progression elicits an event-related potential (ERP component called an early right anterior negativity (ERAN or simply an early anterior negativity (EAN in an early stage of processing the musical syntax. Though the possible underlying mechanism of the EAN is assumed to be probabilistic learning, the effect of the probability of chord progressions on the EAN response has not been previously explored explicitly. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, the empirical conditional probabilities in a Western music corpus were employed as an approximation of the frequencies in previous exposure of participants. Three types of chord progression were presented to musicians and non-musicians in order to examine the correlation between the probability of chord progression and the neuromagnetic response using magnetoencephalography (MEG. Chord progressions were found to elicit early responses in a negatively correlating fashion with the conditional probability. Observed EANm (as a magnetic counterpart of the EAN component responses were consistent with the previously reported EAN responses in terms of latency and location. The effect of conditional probability interacted with the effect of musical training. In addition, the neural response also correlated with the behavioral measures in the non-musicians. CONCLUSIONS/SIGNIFICANCE: Our study is the first to reveal the correlation between the probability of chord progression and the corresponding neuromagnetic response. The current results suggest that the physiological response is a reflection of the probabilistic representations of the musical syntax. Moreover, the results indicate that the probabilistic representation is related to the musical training as well as the sensitivity of an individual.

  4. Characterization and alteration studies of valencian socarrats

    OpenAIRE

    Pinho, Luís; Aura Castro, Elvira; Domenech Carbo, Mª Teresa; DOMENECH CARBO, ANTONIO

    2008-01-01

    The need for a conservation-restoration intervention on a series of socarrats originating from archaeological excavations in Manises (Valencia) and the lack of studies about them have motivated research into the materials and technologies used for their production. The lack of research work into the study of Valencian socarrats presently outlines certain discussion about its technique. However, its ornamental technique would be better linked with wall paintings than with ceramic ones, thus...

  5. Depression in Mild Cognitive Impairment is associated with Progression to Alzheimer's Disease : A Longitudinal Study

    NARCIS (Netherlands)

    Van der Mussele, Stefan; Fransen, Erik; Struyfs, Hanne; Luyckx, Jill; Marien, Peter; Saerens, Jos; Somers, Nore; Goeman, Johan; De Deyn, Peter P.; Engelborghs, Sebastiaan

    2014-01-01

    Background: Behavioral and psychological signs and symptoms of dementia (BPSD) belong to the core symptoms of dementia and are also common in mild cognitive impairment (MCI). Objective: This study would like to contribute to the understanding of the prognostic role of BPSD in MCI for the progression

  6. Stable isotope studies. Progress report, August 1, 1974--July 31, 1975

    International Nuclear Information System (INIS)

    Progress is reported in the following studies: selective two-step laser-induced photodissociation, unimolecular processes induced by multiple-photon absorption, and vibrational energy transfer processes involving isotopic species of sulfur dioxide. These laser-induced chemical reactions can possibly be applied to isotope separation

  7. Academic dismissal policy for medical students : effect on study progress and help-seeking behaviour

    NARCIS (Netherlands)

    Stegers-Jager, Karen M.; Cohen-Schotanus, Janke; Splinter, Ted A. W.; Themmen, Axel P. N.

    2011-01-01

    CONTEXT Medical students often fail to finish medical school within the designated time. An academic dismissal (AD) policy aims to enforce satisfactory progress and to enable early identification and timely support or referral of struggling students. In this study, we assessed whether the implementa

  8. Study to Minimize Learning Progress Differences in Software Learning Class Using PLITAZ System

    Science.gov (United States)

    Dong, Jian-Jie; Hwang, Wu-Yuin

    2012-01-01

    This study developed a system using two-phased strategies called "Pause Lecture, Instant Tutor-Tutee Match, and Attention Zone" (PLITAZ). This system was used to help solve learning challenges and to minimize learning progress differences in a software learning class. During a teacher's lecture time, students were encouraged to anonymously express…

  9. The Eastern Lau Basin Integrated Studies Site (ISS): Recent Progress and Future Plans

    Science.gov (United States)

    Wiens, D.; Martinez, F.; Langmuir, C.; Tivey, M.; Childress, J.; Fisher, C.; Wheat, G.; Perfit, M.; Blackman, D.; Kim, S.

    2004-12-01

    Rapid progress is being made in understanding the Eastern Lau Spreading Center (ELSC) Integrated Studies Site, which is a new focus area in the Ridge 2000 Program. The ELSC, located in the western Pacific near Tonga, is a 390 km-long first-order ridge segment that displays a broad range of effects of the back-arc environment. Its southern end, at only 40 km from the Tonga arc volcanic front, is propagating southward into a back-arc rift. Its northern end is 100 km from the volcanic front and terminates at a large, nontransform offset. The ELSC undergoes substantial and systematic changes in primary parameters affecting crustal accretion including spreading rate and mantle source composition. As a consequence it displays large changes along its length in lava chemistry, axial depth and morphology, melt lens characteristics, and crustal thickness and structure. A focus of the work at the ELSC is to understand how changes in these forcing functions affect crustal accretion, hydrothermal venting, and faunal composition and abundance. A geophysical/hydrothermal study of the entire ELSC during an initial R2K cruise in April-May 2004 (PI: Martinez) disclosed a surprisingly high level of hydrothermal activity along the ELSC. This survey involved shipboard multibeam, two deep-towed sonars (DSL120A and IMI30), and concurrent MAPR/Chemical Scanner, CTD/rosette tow-yos, and vertical casts. Hydrothermal activity as indicated by water column plumes increases toward the north, even though magmatic robustness decreases. An ancillary study (PI: Thurnherr) also deployed autonomous floats during this cruise to investigate deep circulation patterns that affect hydrothermal plumes and faunal dispersal. A second cruise in September 2004 (PI: Langmuir) focused on locating vent sources using ABE, petrological sampling, and determining water column properties. Three additional cruises are scheduled during 2005. The first (PI: Tivey) will provide an initial characterization of vent fields

  10. Whole-range studies on alien plant invasion: recent progress and future prospects

    OpenAIRE

    Hongyu Niu; Hao Shen; Wanhui Ye

    2010-01-01

    The regions invaded by alien species are normally disjunct from their native ranges, so it is difficult to understand the reasons for successful invasion through studies conducted only in native or invasive ranges. Many researchers have engaged in whole-range studies of invasive species, i.e. studying the exotics both in their introduced and native ranges, in order to explain the present geographical patterns and invasion mechanisms of alien plants. Here, we review progress in whole-range stu...

  11. Incidence and Progression of Aortic Valve Calcium in the Multi-Ethnic Study of Atherosclerosis (MESA)

    OpenAIRE

    Owens, David S.; Katz, Ronit; Takasu, Junichiro; Kronmal, Richard; Budoff, Matthew J.; O’Brien, Kevin D.

    2010-01-01

    Aortic valve calcium (AVC) is common among older adults and shares epidemiologic and histopathologic similarities to atherosclerosis. However, prospective studies have failed to identify meaningful risk-associations with incident (“new”) AVC or its progression. In this study, AVC was quantified from serial computed tomography (CT) images in 5,880 participants (aged 45–84 years) of the Multi-Ethnic Study of Atherosclerosis, using Agatston methodology. Multivariate backwards selection modeling ...

  12. Quantitative studies in radiopharmaceutical science. Progress report, April 1-August 31, 1986

    International Nuclear Information System (INIS)

    This report covers progress made during the first reporting period since the redirection of the project. In radiochemistry, achievements in fluorine-18 tracer studies including purification and reaction kinetics of 2-fluorodeoxyglucose and production of 6-fluoroDOPA. Radiopharmaceuticals have been prepared and tested for studies on CNS dopaminergic systems. By use of dynamic positron emission tomography the cerebral transport and metabolism of glucose continues to be studied. 6 figs

  13. Liquid effluent study: Ground water characterization data

    Energy Technology Data Exchange (ETDEWEB)

    1990-08-01

    This report is a support document to the Liquid Effluent Study Final Project Report (WHC 1990c). The focus is on sampling and analysis rationale, quality assurance (QA), data validation, and sampling conditions for the groundwater quality assessment. Interpretation of the groundwater data is provided in the final project report. 20 refs., 5 figs., 2 tabs.

  14. TANK 7 CHARACTERIZATION AND WASHING STUDIES

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, D.; Pareizs, J.; Click, D.

    2010-02-04

    A 3-L PUREX sludge sample from Tank 7 was characterized and then processed through a series of inhibited water washes to remove oxalate, sodium, and other soluble ions. Current plans use Tank 7 as one of the feed sources for Sludge Batch 7 (SB7). Tank 7 is high in oxalate due to the oxalic acid cleaning of the sludge heels from Tanks 5 and 6 and subsequent transfer to Tank 7. Ten decant and nine wash cycles were performed over a 47 day period at ambient temperature. Initially, seven decants and seven washes were completed based on preliminary estimates of the number of wash cycles required to remove the oxalate in the sludge. After reviewing the composition data, SRNL recommended the completion of 2 or 3 more decant/wash cycles to ensure all of the sodium oxalate had redissolved. In the first 7 washes, the slurry oxalate concentration was 12,300 mg/kg (69.6% oxalate removal compared to 96.1% removal of the other soluble ions). After all ten decants were complete, the slurry oxalate concentration was 3,080 mg/kg (89.2% oxalate removal compared to 99.0% of the other soluble ions). The rate of dissolution of oxalate increased significantly with subsequent washes until all of the sodium oxalate had been redissolved after seven decant/wash cycles. The measured oxalate concentrations agreed very well with LWO predictions for washing of the Tank 7 sample. Highlights of the analysis and washing of the Tank 7 sample include: (1) Sodium oxalate was detected in the as-received filtered solids. 95% of the oxalate was insoluble (undissolved) in the as-received slurry. (2) No sodium oxalate was detected in the post-wash filtered solids. (3) Sodium oxalate is the last soluble species that redissolves during washing with inhibited water. In order to significantly reduce the sodium oxalate concentration, the sludge must be highly washed, leaving the other soluble anions and cations (including sodium) very low in concentration. (4) The post-wash slurry had 1% of the soluble anions

  15. Theoretical studies in hadronic and nuclear physics. Progress report, December 1, 1993--June 30, 1994

    International Nuclear Information System (INIS)

    Under Hadrons in Nuclei and Nuclear Matter the authors research the ways in which the properties of nucleons and mesons are modified in the nuclear medium. Research progress is reported on a number of topics in this general area, including studies of the role of chiral symmetry for finite density or temperature nuclear matter, the use of QCD sum rules to describe baryons in nuclear matter, and color transparency. In the general field of Hadron Physics broad progress included studies of perturbative QCD, heavy quark physics, QCD sum rules, and QCD-based models. Notable progress was also achieved in Relativistic Dynamics in Quark, Hadron, and Nuclear Physics, where an explicit model of composite particles shows how the z-graph physics (which is an essential part of Dirac phenomenology) comes about. In addition, calculations of elastic electron-deuteron scattering based on two-body relativistic dynamics and meson exchange currents were completed, as were studies of quark-anti-quark bound states based on a relativistic quark model. Progress is also reported on the relativistic few-body problem. In the area of Heavy Ion Dynamics and Sharp Lepton Pairs, work continues on the Composite Particle Scenario for the 'Sharp Lepton Problem'. In particular, the scenario can now encompass the anomalous sharp leptons reported from positron irradiation of heavy neutral atoms, establishing such irradiations as an alternative experimental window to the heavy ion experiments

  16. Application of Systems Theory in Longitudinal Studies on the Origin and Progression of Alzheimer's Disease.

    Science.gov (United States)

    Lista, Simone; Khachaturian, Zaven S; Rujescu, Dan; Garaci, Francesco; Dubois, Bruno; Hampel, Harald

    2016-01-01

    This chapter questions the prevailing "implicit" assumption that molecular mechanisms and the biological phenotype of dominantly inherited early-onset alzheimer's disease (EOAD) could serve as a linear model to study the pathogenesis of sporadic late-onset alzheimer's disease (LOAD). Now there is growing evidence to suggest that such reductionism may not be warranted; these suppositions are not adequate to explain the molecular complexities of LOAD. For example, the failure of some recent amyloid-centric clinical trials, which were largely based on the extrapolations from EOAD biological phenotypes to the molecular mechanisms in the pathogenesis of LOAD, might be due to such false assumptions. The distinct difference in the biology of LOAD and EOAD is underscored by the presence of EOAD cases without evidence of familial clustering or Mendelian transmission and, conversely, the discovery and frequent reports of such clustering and transmission patterns in LOAD cases. The primary thesis of this chapter is that a radically different way of thinking is required for comprehensive explanations regarding the distinct complexities in the molecular pathogenesis of inherited and sporadic forms of Alzheimer's disease (AD). We propose using longitudinal analytical methods and the paradigm of systems biology (using transcriptomics, proteomics, metabolomics, and lipidomics) to provide us a more comprehensive insight into the lifelong origin and progression of different molecular mechanisms and neurodegeneration. Such studies should aim to clarify the role of specific pathophysiological and signaling pathways such as neuroinflammation, altered lipid metabolism, apoptosis, oxidative stress, tau hyperphosphorylation, protein misfolding, tangle formation, and amyloidogenic cascade leading to overproduction and reduced clearance of aggregating amyloid-beta (Aβ) species. A more complete understanding of the distinct difference in molecular mechanisms, signaling pathways, as well as

  17. Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study

    DEFF Research Database (Denmark)

    Gouw, A.A.; Flier, W.M. van der; Fazekas, F.;

    2008-01-01

    within the multicenter, multinational Leukoaraiosis and Disability study (n=396). Baseline WMH were scored on MRI by the Fazekas scale and the Scheltens scale. WMH progression was assessed using the modified Rotterdam Progression scale (absence/presence of progression in 9 brain regions). Baseline and......, previous stroke, diabetes, and blood glucose were risk factors for WMH progression. Male sex, hypertension, systolic blood pressure, previous stroke, body mass index, high-density lipoprotein, and triglyceride levels were risk factors for new lacunes. CONCLUSIONS: WMH and lacunes progressed over time...

  18. Joint inversion of geophysical data for site characterization and restoration monitoring. FY97 annual progress report for EMSP

    Energy Technology Data Exchange (ETDEWEB)

    Berge, P.A.; Berryman, J.G.; Bonner, B.P.; Roberts, J.J.; Wildenschild, D.

    1997-01-01

    'The purpose of this project is to develop a computer code for joint in-version of seismic and electrical data, to improve underground imaging for site characterization and remediation monitoring. The computer code developed in this project will invert geophysical data to obtain direct estimates of porosity and saturation underground, rather than inverting for seismic velocity and electrical resistivity or other geophysical properties. This is intended to be a significant improvement in the state-of-the-art of under-ground imaging, since interpretation of data collected at a contaminated site would become much less subjective. The schedule of this project is as follows: In the first year, investigators perform laboratory measurements of elastic and electrical properties of sand-clay mixtures containing various fluids. Investigators also develop methods of relating measurable geophysical properties to porosity and saturation by using rock physics theories, geostatistical, and empirical techniques together with available laboratory measurements. In the second year, investigators finish any necessary laboratory measurements and apply the methods de-veloped in the first year to invert available borehole log data to predict measured properties of cores and sediments from a borehole. Investigators refine the inversion code in the third year and carry out a field experiment to collect seismic and electrical data. Investigators then use the inversion code to invert the field data to produce estimates of porosity and saturation in the field area where the data were collected. This report describes progress made in the first year of this three-year project.'

  19. Characterization of detector systems for photofission studies

    Energy Technology Data Exchange (ETDEWEB)

    Thirolf, P.G.; Habs, D.; Tajima, T. [LMU Muenchen, Garching (Germany); Csatlos, M.; Csige, L.; Gulyas, J.; Krasznahorkay, A. [Inst. Nucl. Res. of the Hungarian Acad. of Sciences, Debrecen (Hungary); Fujiwara, M. [Res. Center f. Nucl. Phys., Osaka University (Japan); Pietralla, N.; Savran, D. [IKP, TU Darmstadt (Germany)

    2009-07-01

    A brilliant source of photon beams in the X-ray-MeV range can be realized by (coherent) Compton backscattering of laser photons off a dense relativistic electron mirror generated from thin (few nm) diamond-like carbon foils. Highly monochromatic photon beams can be expected with unprecedented photon flux intensities of up to 10{sup 12} photons/pulse at 8 MeV photon energy, operated at a laser repetition rate of 10 Hz. Such photon beams will offer new perspectives for photon-induced nuclear structure studies, e.g. in the second and third minima of actinides. Preparing for photofission studies in actinides, Parallel Plate Avalanche gas detector (PPAC) arrays have been commissioned, each equipped with a stack of 15-25 large area fissile actinide targets ({sup 235,238}U, {sup 232}Th), where the actinide targets simultaneously act as detector electrodes. Properties of the detector systems will be presented, which will be included in first experiments at the Darmstadt NEPTUN tagger facility or the NEW SUBARU facility in Osaka.

  20. Nuclear medicine and imaging research (quantitative studies in radiopharmaceutical science). Progress report, January 1, 1984-December 31, 1984

    International Nuclear Information System (INIS)

    This report presents progress in the areas of cardiac nuclear medicine, other imaging studies, investigations with biomolecules, and assessment of risks associated with the clinical use of radiopharmaceuticals

  1. Towards an understanding of career progression for female professors of nursing: a small scale study

    OpenAIRE

    Joyce, Maria

    2012-01-01

    The aim of this study was to generate knowledge of career progression for women professors of nursing, an under researched topic, in order to understand how their professional and personal experiences may have influenced their aspirations and opportunities for career success. This qualitative study gave voice to a small group of women professors of nursing through individual narrative semi-structured interviews, a relatively under-used methodology. The findings are anticipated to have currenc...

  2. SIMS three year study on statistics and environmental factors in health. Technical progress report No. 2

    Energy Technology Data Exchange (ETDEWEB)

    Cuzick, J. M.; Goldstein, I. F.; Rausch, L. E.; Mittal, Yash; Sager, Thomas W.; Switzer, Paul; Whittemore, Alice S.

    1977-12-01

    Progress is reported on a study of statistical methods for the correlation of environmental factors and health effects, with emphasis on the effects of air pollution. Statistical methods and models for describing the effects of the environment, measured in terms of pollution and weather variables on health, so far measured only in terms of respiratory diseases, are discussed. Plans for conducting a six-city pollution health study are also discussed. A list of publications during 1976 and 1977 is included.

  3. Studies of relativistic heavy ion collisions. Annual progress report, January 1-July 31, 1985

    International Nuclear Information System (INIS)

    Progress is reported on a program to study direct single electron production in relativistic p-A and A-A collisions. Another experiment reported using direct leptons as probes of the precursor quark-gluon level processes has begun with the design and construction of a di-lepton spectrometer. Subthreshold K- and antiproton production were studied. A proposal was made to search for quark matter and other new phenomena utilizing heavy ion collisions at the AGS

  4. Progress of nuclide tracing technique in the study of soil erosion in recent decade

    International Nuclear Information System (INIS)

    In the last decade nuclide tracing technique has been widely employed in the investigation of soil erosion, which makes the studies of soil erosion into a new and rapid development period. This paper tried to review the recent progress of using 137Cs, 210Pbex, 7Be, composite tracers and REE-INAA in soil erosion rate, sedimentation rate, sediment source and soil erosion processes study, and also the existing research results. The trends for future development and questions are also discussed. (authors)

  5. SERDP munition disposal source characterization pilot study

    Energy Technology Data Exchange (ETDEWEB)

    McCallen, R.C.; Couch, R.G.; Fried, L.E. [and others

    1995-09-01

    The Strategic Environmental Research and Development Program (SERDP) is supporting studies to develop and implement technologies for the safe, efficient, and environmentally sound disposal of obsolete munitions and propellants which are stored at various locations across the country. One proposed disposal technique is the open-air burning or detonation (OB/OD) of this material. Although OB/OD is viewed as an efficient and cost-effective method for reducing the inventory of unwanted munitions and propellants, questions regarding its safety and environmental impacts must be addressed. Since very large amounts of munitions and propellants must be consumed inexpensively in relatively short time periods and with the very restrictive Federal and State regulations on environmental issues, it is clear that traditional OB/OD procedures will not be acceptable and that it is necessary to develop modified or advanced OB/OD technology. The effectiveness and environmental impact of the OB/OD technology must be verified by experimental data and with validated numerical models for acceptance by Federal and State regulators. Specifically, technology must be developed and tested that minimizes toxic bum and detonation products the noise (peak pressure) and destructive effect (impulse) of the explosive blast generation and travel distance of shrapnel, and entrainment of dust. Three explosion attenuation scenarios are analyzed: Contained water, aqueous foams, and wet sand.

  6. Progression to impaired glucose regulation and diabetes in the population-based Inter99 study

    DEFF Research Database (Denmark)

    Engberg, Susanne; Vistisen, Dorte; Lau, Cathrine;

    2009-01-01

    prevention study, the Inter99 study, 4,615 individuals without diabetes at baseline and with relevant follow-up data were divided into a low- and a high-risk group based on a risk estimate of ischemic heart disease or the presence of risk factors (smoking, hypertension, hypercholesterolemia, obesity, or......Objective: To estimate the progression rates to impaired glucose regulation (impaired fasting glucose or impaired glucose tolerance) and diabetes in the Danish population-based Inter99 study and in a high-risk subpopulation, separately. Research Design and Methods: From a population-based primary...... having impaired glucose tolerance). High-risk individuals (57.1%) were examined with an oral glucose tolerance test at 1- and 3-year, and all the participants were re-examined at 5-year follow-up. Person-years at risk were calculated. Progression rates to impaired glucose regulation and diabetes were...

  7. Accelerator research studies: Technical progress report for the period June 1, 1986 to May 31, 1987

    International Nuclear Information System (INIS)

    Progress is reported in the study of instabilities and emittance growth in periodic focusing systems for intense beams, collective ion acceleration by intense electron beams and pulse-powered plasma focus, and microwave sources and parameter scaling for high-frequency linacs. Results of a solenoid lens realignment are reported. Theoretical work with particle simulation codes is underway. Laser-controlled collective ion acceleration was demonstrated, a time-resolved Thomson spectrometer was developed, and theoretical studies have led to the development of improved analytical and simulation models describing the equilibrium state and the collective acceleration mechanism in an electron beam with co-moving ions. Progress is reported in the development of a gyroklystron electron gun, and theoretical work on frequency scaling and wakefield effects resulting in codes for quick evaluation of different parameter regimes for electron-positron colliders is discussed. Studies of quadrupole wakefield effects have commenced

  8. Genetic Breeding and Diversity of the Genus Passiflora: Progress and Perspectives in Molecular and Genetic Studies

    Directory of Open Access Journals (Sweden)

    Carlos Bernard M. Cerqueira-Silva

    2014-08-01

    Full Text Available Despite the ecological and economic importance of passion fruit (Passiflora spp., molecular markers have only recently been utilized in genetic studies of this genus. In addition, both basic genetic researches related to population studies and pre-breeding programs of passion fruit remain scarce for most Passiflora species. Considering the number of Passiflora species and the increasing use of these species as a resource for ornamental, medicinal, and food purposes, the aims of this review are the following: (i to present the current condition of the passion fruit crop; (ii to quantify the applications and effects of using molecular markers in studies of Passiflora; (iii to present the contributions of genetic engineering for passion fruit culture; and (iv to discuss the progress and perspectives of this research. Thus, the present review aims to summarize and discuss the relationship between historical and current progress on the culture, breeding, and molecular genetics of passion fruit.

  9. Characterization of contaminant transport by gravity, capillarity and barometric pumping in heterogeneous vadose regimes. 1998 annual progress report

    International Nuclear Information System (INIS)

    'The intent of this research program is to obtain an improved understanding of vadose zone transport processes and to develop field and modeling techniques required to characterize contaminant transport in the unsaturated zone at DOE sites. For surface spills and near-surface leaks of chemicals, the vadose zone may well become a long-term source of contamination for the underlying water table. Transport of contaminants can occur in both the liquid and gas phases of the unsaturated zone. This transport occurs naturally as a result of diffusion, buoyancy forces (gravity), capillarity and barometric pressure variations. In some cases transport can be enhanced by anisotropies present in hydrologic regimes. This is particularly true for gas-phase transport which may be subject to vertical pumping resulting from atmospheric pressure changes. For liquid-phase flows, heterogeneity may enhance the downward transport of contaminants to the water table depending on soil properties and the scale of the surface spill or near-surface leak. Characterization techniques based upon the dynamics of transport processes are likely to yield a better understanding of the potential for contaminant transport at a specific site than methods depending solely on hydrologic properties derived from a borehole. Such dynamic-characterization techniques can be useful for evaluating sites where contamination presently exists as well as for providing an objective basis to evaluate the efficacy of proposed as well as implemented clean-up technologies. The real-time monitoring of processes that may occur during clean-up of tank waste and the mobility of contaminants beneath the Hanford storage tanks during sluicing operations is one example of how techniques developed in this effort can be applied to current remediation problems. In the future, such dynamic-characterization methods might also be used as part of the site-characterization process for determining suitable locations of new DOE facilities

  10. A Study on the General Educational Requirements for Access to Vocational Education. Progress Report. Surveys and Studies in Adult Education.

    Science.gov (United States)

    Khoi, Le Thanh

    Based on responses received from Argentina, Botswana, Egypt, and the Republic of Korea, this progress report consists of analyses of the case studies and a comparative survey. Part l analyzes the reports of each of the four countries individually. Argentina's report is discussed in terms of its four chapters: General Background, Method of…

  11. Association Study between Promoter Polymorphism of TPH1 and Progression of Idiopathic Scoliosis

    Science.gov (United States)

    Yablanski, Vasil; Nikolova, Svetla; Vlaev, Evgeni; Savov, Alexey; Kremensky, Ivo

    2016-01-01

    The concept of disease-modifier genes as an element of genetic heterogeneity has been widely accepted and reported. The aim of the current study is to investigate the association between the promoter polymorphism TPH1 (rs10488682) and progression of idiopathic scoliosis (IS) in Eastern European population sample. A total of 105 patients and 210 healthy gender-matched controls were enrolled in this study. The TPH1 promoter polymorphism was genotyped by amplification followed by restriction. The statistical analysis was performed by Fisher's Exact Test. The results indicated that the genotypes and alleles of TPH1 (rs10488682) are not correlated with curve severity, curve pattern, or bracing. Therefore, the examined polymorphic variant could not be considered as a genetic factor with modifying effect of IS. In conclusion, this case-control study revealed no statistically significant association between TPH1 (rs10488682) and progression of IS in Eastern European population sample. These preliminary results should be replicated in extended population studies including larger sample sizes. The identification of molecular markers for IS could be useful for a more accurate prognosis of the risk for a rapid progression of the curve. That would permit early stage treatment of the patient with the least invasive procedures. PMID:27293961

  12. Investigation on non-glass laser fusion targets: their fabrication, characterization, and transport. Charged Particle Research Laboratory report No. 2-81, progress report, June 1, 1980-January 31, 1981

    International Nuclear Information System (INIS)

    A summary is presented of the research progress made under LLNL Subcontract 8320003 for the period of June 1, 1980 through January 31, 1981. The main theme of the research has continued to be the development of techniques for fabricating, characterizing, and transporting laser fusion targets on a continuous basis. The target fabrication techniques are intended mainly for non-glass spherical shell targets, both cryogenic and non-cryogenic. Specifically, progress has been made in each of the following categories. (1) Investigation of liquid hydrogen behavior inside a spherical laser fusion target. (2) Development of automated target characterization scheme. (3) Study of cryogenic target fabrication scheme utilizing cold-gas-levitation and electric field positioning. (4) Development of a cryogenic target fabrication system based on target free-fall method. (5) Generation of hydrogen powder using electro-hydrodynamic spraying. (6) Study of target-charging techniques for application to contactless cryogenic target fabrication. (7) Development of hollow metal sphere production technique. A brief summary of the research progress made in each category is presented

  13. Investigation on non-glass laser fusion targets: their fabrication, characterization, and transport. Charged Particle Research Laboratory report No. 2-81, progress report, June 1, 1980-January 31, 1981

    Energy Technology Data Exchange (ETDEWEB)

    Kim, K.

    1981-01-01

    A summary is presented of the research progress made under LLNL Subcontract 8320003 for the period of June 1, 1980 through January 31, 1981. The main theme of the research has continued to be the development of techniques for fabricating, characterizing, and transporting laser fusion targets on a continuous basis. The target fabrication techniques are intended mainly for non-glass spherical shell targets, both cryogenic and non-cryogenic. Specifically, progress has been made in each of the following categories. (1) Investigation of liquid hydrogen behavior inside a spherical laser fusion target. (2) Development of automated target characterization scheme. (3) Study of cryogenic target fabrication scheme utilizing cold-gas-levitation and electric field positioning. (4) Development of a cryogenic target fabrication system based on target free-fall method. (5) Generation of hydrogen powder using electro-hydrodynamic spraying. (6) Study of target-charging techniques for application to contactless cryogenic target fabrication. (7) Development of hollow metal sphere production technique. A brief summary of the research progress made in each category is presented.

  14. Site characterization studies for the Iranian National Observatory

    CERN Document Server

    Khosroshahi, Habib G

    2011-01-01

    We report on the Iranian National Observatory (INO) ongoing site characterization studies for INO 3.4m optical telescope under development. Iran benefits from high altitude mountains and a relatively dry climate, thus offer many suitable sites for optical observations. The site selection (2001-2007) studies resulted in two promising sites in central Iran, one of which will host the 3.4m telescope. The studies between 2008 and 2010 aimed at detail characterization of the two sites. This involved measurements of a number of parameters including the wind speed and wind direction, astronomical seeing, sky brightness and microthermal variations.

  15. Studies of heavy fermion systems: Progress report, July 1, 1986-December 31, 1988

    International Nuclear Information System (INIS)

    Major projects put forward in the original proposal were: radiation damage studies of the heavy fermion superconductors UBe13 and UPt3; chemical substitution experiments, including CeCu/sub 6-x/M/sub x/; high magnetic field specific heat measurements; search for new heavy fermion systems (HFS). A summary of results on these projects will be discussed first, followed by additional work done during the contract period - some of which is still in progress

  16. An Overview of Recent Progress in the Study of Distributed Multi-agent Coordination

    OpenAIRE

    Cao, Yongcan; Yu, Wenwu; Ren, Wei; Chen, Guanrong

    2012-01-01

    This article reviews some main results and progress in distributed multi-agent coordination, focusing on papers published in major control systems and robotics journals since 2006. Distributed coordination of multiple vehicles, including unmanned aerial vehicles, unmanned ground vehicles and unmanned underwater vehicles, has been a very active research subject studied extensively by the systems and control community. The recent results in this area are categorized into several directions, suc...

  17. [Synchrotron studies of x-ray reflectivity from surfaces]. Technical progress report

    Energy Technology Data Exchange (ETDEWEB)

    Pershan, P.S.

    1992-03-03

    Following a long period of theoretical interest, but only limited measurements, there has recently been an increased number of attempts to expand the relative paucity of experimental information on the structure of liquid surfaces using techniques as diverse as ellipsometry, micro-force balances, non-linear optics, Auger and photoelectron spectroscopy, and x-ray scattering. Our group has played a leading role in the currently expanding application of scattering techniques to the general problem of characterizing the microscopic structure of liquid surfaces and we propose here that this work be extended specifically to liquid metals. In the following sections we will briefly describe the salient features of x-ray scattering that are relevant to the current project, the progress that we have made in the current grant period and the work that we propose to carry out in the forthcoming grant period.

  18. Process development studies on the bioconversion of cellulose and production of ethanol. Progress report, September 1, 1978

    Energy Technology Data Exchange (ETDEWEB)

    Wilke, C.R.

    1978-09-01

    Progress is reported in studies on the pretreatment of cellulosic materials to facilitate enzymatic hydrolysis, sulfuric acid hydrolysis, investigation of the Purdue processing scheme including an economic analysis, and the fermentability of the enzymatic hydrolyzate. Progress is also reported on enzyme fermentation studies, hydrolysis reactor development, and utilization of hemicellulose sugars. (JSR)

  19. A generic approach does not work : Disciplinary differences as explanation for study progress in higher professional education

    NARCIS (Netherlands)

    Kamphorst, J. C.; Hofman, W. H. A.; Jansen, E. P. W. A.; Terlouw, C.

    2012-01-01

    A generic approach does not work. Disciplinary differences as explanation for study progress in higher professional education. We combine concepts of Tinto's theory on student departure and Becher's theory on disciplinary tribes for explaining study progress in universities. We collected data with a

  20. Student Expectations, Motivations, Target Language Use, and Perceived Learning Progress in a Summer Study Abroad Program in Germany

    Science.gov (United States)

    Badstubner, Tina; Ecke, Peter

    2009-01-01

    This study investigated students' motives for participating in a short-term study abroad program in Germany, their expectations about learning progress at the beginning of the program, and their perceived progress in various language skills at the end of the program. Findings indicated that students' expectations were higher than their perceived…

  1. Cerebral hypometabolism in progressive supranuclear palsy studied with positron emission tomography

    Energy Technology Data Exchange (ETDEWEB)

    Foster, N.L.; Gilman, S.; Berent, S.; Morin, E.M.; Brown, M.B.; Koeppe, R.A.

    1988-09-01

    Progressive supranuclear palsy (PSP) is characterized by supranuclear palsy of gaze, axial dystonia, bradykinesia, rigidity, and a progressive dementia. Pathological changes in this disorder are generally restricted to subcortical structures, yet the type and range of cognitive deficits suggest the involvement of many cerebral regions. We examined the extent of functional impairment to cerebral cortical and subcortical structures as measured by the level of glucose metabolic activity at rest. Fourteen patients with PSP were compared to 21 normal volunteers of similar age using 18F-2-fluoro-2-deoxy-D-glucose and positron emission tomography. Glucose metabolism was reduced in the caudate nucleus, putamen, thalamus, pons, and cerebral cortex, but not in the cerebellum in the patients with PSP as compared to the normal subjects. Analysis of individual brain regions revealed significant declines in cerebral glucose utilization in most regions throughout the cerebral cortex, particularly those in the superior half of the frontal lobe. Declines in the most affected regions of cerebral cortex were greater than those in any single subcortical structure. Although using conventional neuropathological techniques the cerebral cortex appears to be unaffected in PSP, significant and pervasive functional impairments in both cortical and subcortical structures are present. These observations help to account for the constellation of cognitive symptoms in individual patients with PSP and the difficulty encountered in identifying a characteristic psychometric profile for this group of patients.

  2. Cerebral hypometabolism in progressive supranuclear palsy studied with positron emission tomography

    International Nuclear Information System (INIS)

    Progressive supranuclear palsy (PSP) is characterized by supranuclear palsy of gaze, axial dystonia, bradykinesia, rigidity, and a progressive dementia. Pathological changes in this disorder are generally restricted to subcortical structures, yet the type and range of cognitive deficits suggest the involvement of many cerebral regions. We examined the extent of functional impairment to cerebral cortical and subcortical structures as measured by the level of glucose metabolic activity at rest. Fourteen patients with PSP were compared to 21 normal volunteers of similar age using 18F-2-fluoro-2-deoxy-D-glucose and positron emission tomography. Glucose metabolism was reduced in the caudate nucleus, putamen, thalamus, pons, and cerebral cortex, but not in the cerebellum in the patients with PSP as compared to the normal subjects. Analysis of individual brain regions revealed significant declines in cerebral glucose utilization in most regions throughout the cerebral cortex, particularly those in the superior half of the frontal lobe. Declines in the most affected regions of cerebral cortex were greater than those in any single subcortical structure. Although using conventional neuropathological techniques the cerebral cortex appears to be unaffected in PSP, significant and pervasive functional impairments in both cortical and subcortical structures are present. These observations help to account for the constellation of cognitive symptoms in individual patients with PSP and the difficulty encountered in identifying a characteristic psychometric profile for this group of patients

  3. Increasing waterflood reserves in the Wilmington oil field through improved reservoir characterization and reservoir management. Quarterly technical progress report, March 21, 1995--June 30, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, D.; Clarke, D. [Long Beach City Dept. of Oil Properties, CA (United States); Walker, S.; Phillips, C.; Nguyen, J. [Tidelands Oil Production Co. (United States); Moos, D. [Stanford Univ. (United States); Tagbor, K. [MPI (United States)

    1995-07-26

    The main objective of this project is the transfer of technologies, methodologies, and findings developed and applied in this project to other operators of Slope and Basin Clastic Reservoirs. This project will study methods to identify sands with high remaining oil saturation and to recomplete existing wells using advanced completion technology. The identification of the sands with high remaining oil saturation will be accomplished by developing a deterministic 3-D geologic model and by using a state of the art reservoir management computer software. The wells identified by the geologic and reservoir engineering work as having the best potential will be logged with a pulsed acoustic cased-hole logging tool. The application of the logging tools will be optimized in the lab by developing a rock-log model. The wells that are shown to have the best oil production potential will be recompleted. The recompletions will be optimized by evaluating short radius and ultra-short radius lateral recompletions. Technical progress is reported for the following tasks: Reservoir characterization; reservoir engineering; 3-D geologic modeling; pulsed acoustic logging; and technology transfer.

  4. Can Online MBA Programs Allow Professional Working Mothers to Balance Work, Family, and Career Progression? A Case Study in China

    OpenAIRE

    Kibelloh, Mboni; Bao, Yukun

    2014-01-01

    Career progression is a general concern of professional working mothers in China. The purpose of this paper is to report a qualitative study of Chinese professional working mothers that explored the perceptions of online Master's of Business Administration (MBA) programmes as a tool for career progression for working mothers balancing work and family in China. The objective was to examine existing work-family and career progression conflicts, the perceived usefulness of online MBA in balancin...

  5. Supervised progressive cross-continuum strength training compared with usual care in older medical patients: study protocol for a randomized controlled trial (the STAND-Cph trial)

    DEFF Research Database (Denmark)

    Pedersen, Mette Merete; Petersen, Janne; Beyer, Nina;

    2016-01-01

    BACKGROUND: Hospitalization in older adults is characterized by physical inactivity and a risk of losing function and independence. Systematic strength training can improve muscle strength and functional performance in older adults. Few studies have examined the effect of a program initiated during...... hospitalization and continued after discharge. We conducted a feasibility study prior to this trial and found a progression model for loaded sit-to-stands feasible in older medical patients. This study aims to determine whether a simple supervised strength training program for the lower extremities (based on the...

  6. Numerical study of how creep and progressive stiffening affect the growth stress formation in trees

    DEFF Research Database (Denmark)

    Ormarsson, Sigurdur; Dahlblom, O.; Johansson, M.

    2010-01-01

    and they are highly influenced by climate, biologic and material related factors. To increase the knowledge of the stress formation a finite element model was created to study how the growth stresses develop during the tree growth. The model is an axisymmetric general plane strain model where material...... for all new annual rings is progressively added to the tree during the analysis. The material model used is based on the theory of small strains (where strains refer to the undeformed configuration which is good approximation for strains less than 4%) where so-called biological maturation strains...... (growth-related strains that form in the wood fibres during their maturation) are used as a driver for the stress generation. It is formulated as an incremental material model that takes into account elastic strain, maturation strain, viscoelastic strain and progressive stiffening of the wood material...

  7. STUDY OF DELETION OF P16 GENE IN THE PROGRESSION OF BRAIN ASTROCYTOMAS

    Institute of Scientific and Technical Information of China (English)

    Zhai Guang; Yuan Xianhou

    1998-01-01

    Objective:To study the relationship between deletion of P16 gene and occurrence and progression of astrocytomas. Methods: The techniques of polymerase chain reaction (PCR) and immunohistochemistry were used to detect the deletion of exon2 of P16 gene and expression of P16 gene in 52 cases of Brain astrocytoma.Results: The deletion rate of exon2 of P16 gene in the tumors analyzed was 34.6%. Most of them with deletion of exon2 of p16 gene were high grade astrocytomas (grade Ⅲ 42%, grade Ⅳ 50%). 61.5% of the tumors were absent from expression of p16 and the deletion rate of p16 protein increased with the grade of astrocytoma (X2=10.83, P<0.005). Conclusion: Deletion of p16 gene and protein may correlate with the malignant progression of astrocytoma.

  8. Hot dry rock reservoir characterization and modeling. Progress report, October 1, 1978-September 30, 1979. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Achenbach, J.D.; Bazant, Z.P.; Dundurs, J.; Keer, L.M.; Nemat-Nasser, S.; Mura, T.; Weertman, J.

    1980-02-01

    Resuls of analytical and experimental studies on hydraulic fracturing and on the characterization and modeling of hot dry rock geothermal energy reservoirs are presented. The first four Chapters are concerned with problems of thermal cracking and heat transfer, with fluid flow through large cracks, and with the stable and unstable growth of water-filled cracks under internal pressure and thermal loading. Experiments are reported, which present visually observable hydraulic fractures in transparent materials to demonstrate the interaction between hydraulic fractures and the development of thermal cracks. Seismic detection of hydraulic fractures is discussed, and a method to invert crack-scattering data is presented. Separate abstracts were prepared for each of the six chapters.

  9. Progress in Marine Meteorology Studies in China during 1999-2002

    Institute of Scientific and Technical Information of China (English)

    王东晓; 秦曾灏; 施平

    2004-01-01

    The progresses of marine meteorology studies achieved in China during the four year period from 1999 to 2002 are summarized in six directions: air-sea flux, marine meteorology in high latitudes, marine disasters, connection between ocean and weather/climate in China, remote sensing applications and new methodologies in marine meteorology. Compared to the previous ones, these studies adopted much more first-hand datasets, and more scientific issues were involved. As an exciting remark, there were so many contributions done by the young scientists. A brief statement about the research strategy of marine meteorology in China for the coming years is also given.

  10. Flinders University of South Australia, Institute for Atomic Studies annual progress report, 1976

    International Nuclear Information System (INIS)

    The Institute of Atomic Studies was established in 1976 to act as a focus for the interaction of scientists and graduate students and for circulation of research reports in a wide variety of disciplines involving the study of the structure and interaction of quantum systems. In this, the first annual progress report, research being conducted in the following areas is reviewed: experimental and theoretical atomic reaction physics, low and intermediate energy nuclear theory, quantum field theory, statistical physics, molecular physics, quantum processes at solid surfaces and quantum chemistry. (J.R.)

  11. Radiation and biophysical studies on cells and viruses. Progress report, April 1, 1976--June 30, 1977

    International Nuclear Information System (INIS)

    Progress is reported on the following research projects: genetic structure of DNA, chromosomes, and nucleoproteins; particle beam studies of radiosensitive sites; division delay in CHO cells induced by partly penetrating alpha particles; location of cellular sites for mutation induction; sites for radioinduced cell transformation using partly penetrating particle beams; gamma-ray and particle irradiation of nucleoproteins and other model systems; quantitation of surface antigens on normal and neoplastic cells by x-ray fluorescence; hyperthermic effects on cell survival and DNA repair mechanisms; and studies on radioinduced cell transformation

  12. [Progress in Proteomic Study of the Penicillin Producer---Penicillium Chrysogenum].

    Science.gov (United States)

    Wang, Shun; Wang, Peihong; Zhang, Nan; Gao, Ruichang

    2015-12-01

    Penicillin is a kind of β-lactam drug which has been applied in the clinical treatment firstly in the world, and it has still been widely used at present. The synthesis and regulation mechanism of Penicillium chrysogenum, which is used to produce penicillin, has been studied quite maturely, but its proteomics research started relatively late and fewer reports were published. This paper reviews the synthesis and application of penicillin, transformation of Penicillium chrysogenum, and the research progress of its proteomics. On this basis, the study highlights the advantages of proteomics in the research of protein expression. PMID:27079113

  13. Study on reduction of accessory horsepower requirements. Eleventh quarterly progress report

    Energy Technology Data Exchange (ETDEWEB)

    1977-04-30

    Progress in a program for optimizing automotive accessory systems to achieve greater vehicle fuel economy and improved accessory performance is reported. The major technical accomplishments during this reporting period were: all candidate advanced air conditioning concepts were evaluated; advanced air conditioning and hybrid accessory drive component trade-studies were completed; improved alternator, water pump and power steering system concepts were evaluated; the vehicle integrated accessory systems trade-study was completed; and the technical summary report for the Phase V Automotive Accessory Systems Optimization Program was initiated. (LCL)

  14. Progress of Study on Application of Rare Earth Metals in Steels

    Institute of Scientific and Technical Information of China (English)

    Wang Longmei; Lin Qin; Ji Jingwen; Lan Denian

    2004-01-01

    With the improvement of the clean steel by degrees, the functions of rare earth metals in steel are more focused on modification of inclusions and micro alloying.The new study concerning the application of RE metals in clean steels were investigated by ICP, metallographic examination, SEM, EDS, EPMA, TEM and IMMA.The mechanism of corrosion resistance in the weather resistance steel was clarified.The mechanism of abrasion resistance and the life of fatigue enhanced in the RE - heavy rails steel were discussed.Progress in study of application of rare earth metals in steels (including weather resistance steel, low alloy steel, and heavy rails steel) was covered in this paper.

  15. Homoarginine and progression of chronic kidney disease: results from the Mild to Moderate Kidney Disease Study.

    Directory of Open Access Journals (Sweden)

    Christiane Drechsler

    Full Text Available BACKGROUND: Homoarginine is an amino acid derivative mainly synthesized in the kidney. It is suggested to increase nitric oxide availability, enhance endothelial function and to protect against cardiovascular diseases. We aimed to investigate the relation between homoarginine, kidney function and progression of chronic kidney disease (CKD. METHODS: We measured plasma homoarginine concentrations in baseline samples of the Mild to Moderate Kidney Disease (MMKD Study, a prospective cohort study of 227 patients with CKD in Europe. Homoarginine concentrations were available in 182 of the baseline samples and in 139 of the prospectively-followed patients. We correlated homoarginine concentrations to parameters of kidney function. The association between homoarginine and progression of CKD was assessed during a follow-up of up to seven years (median 4.45 years, interquartile range 2.54-5.19 using Cox regression analysis. Progression of CKD was defined as doubling of baseline serum creatinine and/or end-stage renal disease. RESULTS: Study participants were at baseline on average 47±13 years old and 65% were male. Mean±standard deviation of homoarginine concentrations were 2.5±1.1 µmol/L and concentrations were incrementally lower at lower levels of GFR with mean concentrations of 2.90±1.02 µmol/L (GFR>90 ml/min, 2.64±1.06 µmol/L (GFR 60-90 ml/min, 2.52±1.24 µmol/L (GFR 30-60 ml/min and 2.05±0.78 µmol/L (GFR<30 ml/min, respectively (p = 0.002. The age- and sex-adjusted risk to reach the renal endpoint was significantly higher by 62% with each decrease by one standard deviation (1.1 µmol/L of homoarginine (HR 1.62, 95% CI 1.16-2.27, p = 0.005. This association was independent of proteinuria (HR 1.56, 95% CI 1.11-2.20, p = 0.01, and was slightly attenuated when adjusting for GFR (HR 1.40 (95% CI 0.98-1.98, p = 0.06. CONCLUSIONS: Homoarginine concentrations are directly correlated with kidney function and are significantly

  16. A Study On In-Vessel Severe Accident Progression In The VVER-1000 Reactor Pressure Vessel

    International Nuclear Information System (INIS)

    In a hypothetic severe accident, there is likelihood that a melt pool is formed and the Reactor Pressure Vessel (RPV) fails due to thermal creep. The present paper is concerned with the in-vessel accident progression in the VVER-1000 RPV. The study includes review of simulation results (RELAP, MELCOR), analysis of accident scenarios, determination of core materials relocation, and simulation of heat transfer of the melt pool formed in the lower plenum. The RELAP, MELCOR codes used for safety analysis are capable of simulation of severe accident progression and identification of accident scenarios in the reactor. However, there is limitation in describing turbulent natural convection heat transfer of a melt pool formed in the lower plenum. Computational Fluid Dynamics (CFD) codes which although are capable of melt pool heat transfer simulation, however, are too expensive. The Effective Convectivity Model (ECM) and Phase-change ECM (PECM) which were developed for melt pool heat transfer simulation are applied. The melt pool configuration, initial conditions are determined based on the analysis of accident scenarios, the ECM/PECM is used to simulate melt pool heat transfer. Results of ECM/PECM simulation are analyzed, compared with available RELAP, MELCOR accident progression data, RPV failure mode and timing are discussed. (author)

  17. [The isolation and characterization of beta-glucosidase gene and beta-glucosidase of Trichoderma viride]: Progress report

    International Nuclear Information System (INIS)

    Our project was to isolate and characterize the enzyme β-glucosidase and to clone and characterize the β-glucosidase gene; our goal is to clone and characterize each of the cellulase genes from Trichoderma. The induction of the Trichoderma reesei cellulase complex by cellulose and by the soluble inducer, sophorose, has been demonstrated. Although the induction of the cellulase complex has previously been well documented, the induction of β-glucosidase had been questioned. 49 refs., 6 figs., 2 tabs

  18. Characterization of the effect of sample quality on high density oligonucleotide microarray data using progressively degraded rat liver RNA

    Directory of Open Access Journals (Sweden)

    Rosenzweig Barry A

    2007-09-01

    Full Text Available Abstract Background The interpretability of microarray data can be affected by sample quality. To systematically explore how RNA quality affects microarray assay performance, a set of rat liver RNA samples with a progressive change in RNA integrity was generated by thawing frozen tissue or by ex vivo incubation of fresh tissue over a time course. Results Incubation of tissue at 37°C for several hours had little effect on RNA integrity, but did induce changes in the transcript levels of stress response genes and immune cell markers. In contrast, thawing of tissue led to a rapid loss of RNA integrity. Probe sets identified as most sensitive to RNA degradation tended to be located more than 1000 nucleotides upstream of their transcription termini, similar to the positioning of control probe sets used to assess sample quality on Affymetrix GeneChip® arrays. Samples with RNA integrity numbers less than or equal to 7 showed a significant increase in false positives relative to undegraded liver RNA and a reduction in the detection of true positives among probe sets most sensitive to sample integrity for in silico modeled changes of 1.5-, 2-, and 4-fold. Conclusion Although moderate levels of RNA degradation are tolerated by microarrays with 3'-biased probe selection designs, in this study we identify a threshold beyond which decreased specificity and sensitivity can be observed that closely correlates with average target length. These results highlight the value of annotating microarray data with metrics that capture important aspects of sample quality.

  19. Nuclide migration study in the QUALITY. Data acquisitions for the Second Progress Report

    International Nuclear Information System (INIS)

    Studies on the chemical and migration behaviour of radionuclides were carried out in the Quantitative Assessment Radionuclide Migration Experiential Facility (QUALITY) for assuring the reliability and for improving the propriety of data concerning nuclide migration used in the Second Progress Report for the geological disposal of high-level radioactive waste. Five studies for solubility, sorption and diffusion concerning nuclide migration were carried out. The overview of each study and the result is as follows: (1) Study on Effect of Carbonate on Np Solubility. Solubilities of Np(IV) were measured as functions of pH and carbonate concentration under reducing conditions. The obtained data could be well described by considering two hydroxo-carbonate complexes, and those stability constants were estimated and compared with the literature data. Consequently, the data obtained in this study were similar to the literature data. (2) Study on Effect of Carbonate on Np Sorption on Bentonite. Distribution coefficients (Kd) of Np(IV) on smectite were measured as a function of carbonate concentration. The obtained Kd values were approximately constant over the carbonate concentration (total carbon concentration 0.04-0.15M). The results of desorption tests by 1M KCl and HCl at the end of sorption experiments showed two different desorption behaviour; Np(IV) was well removed by HCl for the experiments in low carbonate concentration and by KCl for those in high carbonate concentration. (3) Distribution Coefficient Measurements for Cs, Pb and Cm on Rocks. Distribution Coefficients for Cs, Pb and Cm on Japanese major rocks (basalt, mudstone, sandstone, granodiorite and tuff) were measured as a function of ionic strength. The obtained Kd values were either the same orders or higher compared with data used to both fresh and saline groundwater systems in the Second Progress Report. This indicates that the Kd data used in the Second Progress Report are either proper or conservative

  20. On the progression and stability of adolescent identity formation: a five-wave longitudinal study in early-to-middle and middle-to-late adolescence.

    Science.gov (United States)

    Meeus, Wim; van de Schoot, Rens; Keijsers, Loes; Schwartz, Seth J; Branje, Susan

    2010-01-01

    This study examined identity development in a 5-wave study of 923 early-to-middle and 390 middle-to-late adolescents thereby covering the ages of 12-20. Systematic evidence for identity progression was found: The number of diffusions, moratoriums, and searching moratoriums (a newly obtained status) decreased, whereas the representation of the high-commitment statuses (2 variants of a [fore]closed identity: "early closure" and "closure," and achievement) increased. We also found support for the individual difference perspective: 63% of the adolescents remained in the same identity status across the 5 waves. Identity progression was characterized by 7 transitions: diffusion→moratorium, diffusion→early closure, moratorium→closure, moratorium→achievement, searching moratorium→closure, searching moratorium→achievement, and early closure→achievement. PMID:20840241

  1. Studies of radiation-produced radicals and radical ions. Progress report, June 1, 1981-August 31, 1982

    International Nuclear Information System (INIS)

    The discovery and characterization of novel radical ions produced by the γ irradiation of solids continues to be a fertile field for investigation. This Progress Report describes the generation and ESR identification of several new paramagnetic species, some of which have long been sought as important intermediates in radiation chemistry. We have also contributed to a general theoretical problem in ESR spectroscopy. Solid-state studies of electron attachment reactions, both non-dissociative and dissociative, reveal interesting structural and chemical information about the molecular nature of these processes for simple compounds. In particular, ESR measurements of the spin distribution in the products allow a fairly sharp distinction to be drawn between radical anions and radical-anion pairs or adducts. Dimer radical anion formation can also take place but the crystal structure plays a role in this process, as expected. Some radical anions undergo photolysis to give radical-anion pairs which may then revert back to the original radical anion by a thermal reaction. The chemistry of these reversible processes is made more intricate by a competing reaction in which the radical abstracts a hydrogen atom from a neighboring molecule. However, the unraveling of this complication has also served to extend our knowledge of the role of quantum tunneling in chemical reactions. The results of this investigation testify to the potential of solid-state techniques for the study of novel and frangible radical ions. Progress in this field shows no sign of abating, as witness the recent discovery of perfluorocycloalkane radical anions and alkane radical cations

  2. Stability and design criteria studies for compressed air energy storage reservoirs. Progress report, FY 1977.

    Energy Technology Data Exchange (ETDEWEB)

    Smith, G.C.; Stottlemyre, J.A.; Wiles, L.E.; Loscutoff, W.V.; Pincus, H.J.

    1978-03-01

    Progress made during FY-1977 in establishing design criteria to ensure the successful operation and long-term stability of Compressed Air Energy Storage (CAES) reservoirs in underground porous media, such as aquifers is summarized. The formulation of pertinent criteria is important since the long-term stability of air storage reservoirs is probably the item of greatest risk to the successful demonstration and commercialization of the CAES concept. The study has been divided into four phases: (1) state-of-the-art survey, (2) analytical modeling studies, (3) laboratory studies, and (4) field testing. The first of these phases, the state-of-the-art survey for air storage in porous reservoirs, has been completed on schedule and is reported in Section 2. Sections 3 and 4 are progress reports on Phases 2 and 3. No work has been done on Phase 4. It is planned that the field testing phase of this study will be carried out in conjunction with the Department of Energy/Electric Power Research Institute (DOE/EPRI) CAES Demonstration Program. This phase is not scheduled to begin until FY-1979.

  3. WRAP Module 1 sampling strategy and waste characterization alternatives study

    Energy Technology Data Exchange (ETDEWEB)

    Bergeson, C.L.

    1994-09-30

    The Waste Receiving and Processing Module 1 Facility is designed to examine, process, certify, and ship drums and boxes of solid wastes that have a surface dose equivalent of less than 200 mrem/h. These wastes will include low-level and transuranic wastes that are retrievably stored in the 200 Area burial grounds and facilities in addition to newly generated wastes. Certification of retrievably stored wastes processing in WRAP 1 is required to meet the waste acceptance criteria for onsite treatment and disposal of low-level waste and mixed low-level waste and the Waste Isolation Pilot Plant Waste Acceptance Criteria for the disposal of TRU waste. In addition, these wastes will need to be certified for packaging in TRUPACT-II shipping containers. Characterization of the retrievably stored waste is needed to support the certification process. Characterization data will be obtained from historical records, process knowledge, nondestructive examination nondestructive assay, visual inspection of the waste, head-gas sampling, and analysis of samples taken from the waste containers. Sample characterization refers to the method or methods that are used to test waste samples for specific analytes. The focus of this study is the sample characterization needed to accurately identify the hazardous and radioactive constituents present in the retrieved wastes that will be processed in WRAP 1. In addition, some sampling and characterization will be required to support NDA calculations and to provide an over-check for the characterization of newly generated wastes. This study results in the baseline definition of WRAP 1 sampling and analysis requirements and identifies alternative methods to meet these requirements in an efficient and economical manner.

  4. WRAP Module 1 sampling strategy and waste characterization alternatives study

    International Nuclear Information System (INIS)

    The Waste Receiving and Processing Module 1 Facility is designed to examine, process, certify, and ship drums and boxes of solid wastes that have a surface dose equivalent of less than 200 mrem/h. These wastes will include low-level and transuranic wastes that are retrievably stored in the 200 Area burial grounds and facilities in addition to newly generated wastes. Certification of retrievably stored wastes processing in WRAP 1 is required to meet the waste acceptance criteria for onsite treatment and disposal of low-level waste and mixed low-level waste and the Waste Isolation Pilot Plant Waste Acceptance Criteria for the disposal of TRU waste. In addition, these wastes will need to be certified for packaging in TRUPACT-II shipping containers. Characterization of the retrievably stored waste is needed to support the certification process. Characterization data will be obtained from historical records, process knowledge, nondestructive examination nondestructive assay, visual inspection of the waste, head-gas sampling, and analysis of samples taken from the waste containers. Sample characterization refers to the method or methods that are used to test waste samples for specific analytes. The focus of this study is the sample characterization needed to accurately identify the hazardous and radioactive constituents present in the retrieved wastes that will be processed in WRAP 1. In addition, some sampling and characterization will be required to support NDA calculations and to provide an over-check for the characterization of newly generated wastes. This study results in the baseline definition of WRAP 1 sampling and analysis requirements and identifies alternative methods to meet these requirements in an efficient and economical manner

  5. SCHIFF BASES: FACILE SYNTHESIS, SPECTRAL CHARACTERIZATION AND BIOCIDAL STUDIES

    OpenAIRE

    Kalaivani, S.; N. Padma Priya; S. Arunachalam

    2013-01-01

    A family of Schiff bases was synthesized by the reactions of o-aminobenzoic acid and Knovenegal condensate of β-ketoesters in 1:1 ratio. The newly synthesized Schiff bases were characterized by Elemental analyses and spectral (FT-IR, UV–Vis and 1H-NMR) studies and the structures have been proposed tentatively. These compounds were subjected to study their biocidal efficacy against S. epidermidis, E. coli, B. cinerea and A. niger.

  6. SCHIFF BASES: FACILE SYNTHESIS, SPECTRAL CHARACTERIZATION AND BIOCIDAL STUDIES

    Directory of Open Access Journals (Sweden)

    S. Kalaivani

    2013-03-01

    Full Text Available A family of Schiff bases was synthesized by the reactions of o-aminobenzoic acid and Knovenegal condensate of β-ketoesters in 1:1 ratio. The newly synthesized Schiff bases were characterized by Elemental analyses and spectral (FT-IR, UV–Vis and 1H-NMR studies and the structures have been proposed tentatively. These compounds were subjected to study their biocidal efficacy against S. epidermidis, E. coli, B. cinerea and A. niger.

  7. Design study and R and D progress on Japan sodium-cooled fast reactor

    International Nuclear Information System (INIS)

    This paper describes the progress of the design study and research and development (R and D) for the Japan Sodium-cooled Fast Reactor (JSFR) implemented in the 'Fast Reactor Cycle Technology Development (FaCT)' project. A sodium-cooled fast reactor with an electric power of 1,500 MWe is targeted for commercialization at around 2050, and a demonstration reactor assuming a power output from 500 to 750 MWe is planned to start operation at around 2025. R and D on innovative technologies to achieve economic competitiveness and enhance reliability and safety is carried out for the commercialization. A compact reactor vessel without a vessel wall cooling system is pursued in consideration of the wall thickness enough to resist the severest seismic condition. A two-loop cooling system with shortened high-chromium steel piping is a crucial feature, and studies on the hydraulics in the pipe elbow and the fabrication capability of the pipes are being carried out. A double-walled straight tube steam generator is investigated to enhance the reliability against sodium/water reaction, and developmental works are progressing, including the thermal-hydraulic design and trial manufacturing for components. Self-Actuated Shutdown System (SASS) is being developed with safety analysis of the applicability for JSFR and experimental demonstration in the experimental fast reactor JOYO. An advanced fuel handling system is pursued to enhance economic performance. In parallel with considering the necessity of studies on alternative technologies, discussion on whether the innovative technologies can be adopted for JSFR is in progress to be finalized in 2010. (author)

  8. [The progress in application of parathyroid hormone in craniomaxillofacial bone regeneration study].

    Science.gov (United States)

    Chen, X Y; Tang, Z L

    2016-06-01

    Parathyroid hormone(PTH)is synthesized and secreted by chief cell of Gley's glands which possesses dual functions of catabolism and anabolism. It regulates the proliferation and differentiation of multiple cell lines including osteoblast, osteoclast and skeletal lining cells. Furthermore, PTH activates various signaling pathways which control calcium, phosphorous' metabolism and bone conversion, accelerating the bone regeneration and reconstruction. However, the study of PTH in craniomaxillofacial bone regeneration is relatively less and whether the role of parathyroid glands and the mechanism of ossification are consistent with the long bone or not needs further investigation. This review focuses on the progress of PTH in craniomaxillofacial bone regeneration in recent years. PMID:27256534

  9. Studies of supported metal catalysts. Progress report, September 1, 1979-August 31, 1980

    International Nuclear Information System (INIS)

    Research was carried out on four separate catalyst systems: Co-Al2O3; Mo-Al2O3; Co/Mo/Al2O3; and Ni. Work was completed on the interactions between cobalt and γ-Al2O3. Work was begun on the combined Co/Mo/Al2O3 system. A separate study is in progress on support interactions between nickel and a variety of supports; particular emphasis has been on the effect of preparation method

  10. Review: Study progress on mechanism of severe acute pancreatitis complicated with hepatic injury

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xi-ping; WANG Lei; ZHANG Jie

    2007-01-01

    Study on the action mechanism of inflammatory mediators generated by the severe acute pancreatitis (SAP) in multiple organ injury is a hotspot in the surgical field. In clinical practice, the main complicated organ dysfunctions are shock, respiratory failure, renal failure, encephalopathy, with the rate of hepatic diseases being closely next to them. The hepatic injury caused by SAP cannot only aggravate the state of pancreatitis, but also develop into hepatic failure and cause patient death. Its complicated pathogenic mechanism is an obstacle in clinical treatment. Among many pathogenic factors, the changes ofvasoactive substances, participation of inflammatory mediators as well as OFR (oxygen free radical), endotoxin, etc. may play important roles in its progression.

  11. Arterial hypertension and skin allergy are risk factors for progression from dengue to dengue hemorrhagic fever: a case control study.

    Directory of Open Access Journals (Sweden)

    Maria Glória Teixeira

    2015-05-01

    Full Text Available Currently, knowledge does not allow early prediction of which cases of dengue fever (DF will progress to dengue hemorrhagic fever (DHF, to allow early intervention to prevent progression or to limit severity. The objective of this study is to investigate the hypothesis that some specific comorbidities increase the likelihood of a DF case progressing to DHF.A concurrent case-control study, conducted during dengue epidemics, from 2009 to 2012. Cases were patients with dengue fever that progressed to DHF, and controls were patients of dengue fever who did not progress to DHF. Logistic regression was used to estimate the association between DHF and comorbidities.There were 490 cases of DHF and 1,316 controls. Among adults, progression to DHF was associated with self-reported hypertension (OR = 1.6; 95% CI 1.1-2.1 and skin allergy (OR = 1.8; 95% CI 1.1-3.2 with DHF after adjusting for ethnicity and socio-economic variables. There was no statistically significant association between any chronic disease and progression to DHF in those younger than 15 years.Physicians attending patients with dengue fever should keep those with hypertension or skin allergies in health units to monitor progression for early intervention. This would reduce mortality by dengue.

  12. Accelerator research studies. Technical progress report, June 1, 1992--May 31, 1993

    Energy Technology Data Exchange (ETDEWEB)

    1993-03-01

    The Accelerator Research Studies program at the University of Maryland, sponsored by the Department of Energy under grant number DE-FG05-91ER40642, is currently in the second year of a three-year funding cycle. The program consists of the following three tasks: TASK A, ``Study of Transport and Longitudinal Compression of Intense, High-Brightness Beams,`` (P.I., M. Reiser); TASK B, ``Study of Collective Ion Acceleration by Intense Electron Beams and Pseudospark Produced High Brightness Electron Beams,`` (Co-P.I.`s, W.W. Destler, M. Reiser, M.J. Rhee, and C.D. Striffler); TASK C, ``Study of a Gyroklystron High-Power Microwave Source for Linear Colliders,`` (Co-P.I.`s, V.L. Granatstein, W. Lawson, M. Reiser, and C.D. Striffler). In this report we document the progress that has been made during the past year for each of the three tasks.

  13. Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges.

    Science.gov (United States)

    Deelen, Joris; Beekman, Marian; Capri, Miriam; Franceschi, Claudio; Slagboom, P Eline

    2013-04-01

    Human lifespan variation is mainly determined by environmental factors, whereas the genetic contribution is 25-30% and expected to be polygenic. Two complementary fields go hand in hand in order to unravel the mechanisms of biological aging: genomic and biomarker research. Explorative and candidate gene studies of the human genome by genetic, transcriptomic, and epigenomic approaches have resulted in the identification of a limited number of interesting positive linkage regions, genes, and pathways that contribute to lifespan variation. The possibilities to further exploit these findings are rapidly increasing through the use of novel technologies, such as next-generation sequencing. Genomic research is progressively being integrated with biomarker studies on aging, including the application of (noninvasive) deep phenotyping and omics data - generated using novel technologies - in a wealth of studies in human populations. Hence, these studies may assist in obtaining a more holistic perspective on the role of the genome in aging and lifespan regulation. PMID:23423909

  14. Fundamental studies in isotope chemistry. Progress report, 1 October 1980-1 August 1981

    International Nuclear Information System (INIS)

    The current program, as in the past, utilizes theoretical advances made specifically with respect to isotope chemistry in the study of the structure of matter. Experimental investigation using isotope effects provides a unique tool for the determination of the mean square force on an atom in a molecule and how it is affected by intermolecular forces. We have completed the systematic study of the isotope chemistry of hydrogen. Studies have been made of the isotopic reduced partition function ratio, (s/s')f, of thirty-nine diatomic and nineteen polyatomic hydrides. It encompasses compounds of hydrogen with every element in each row and each column of the periodic table. This progress report also includes a description of our final design for sampling a cryogenic liquid. Such a sampler is necessary if we are to realize the full potential of the isotopic fractionation method to study the mean square forces and torques in polyatomic liquids

  15. Progression of solitary and multifocal papillary thyroid carcinoma— a retrospective study of 368 patients

    Institute of Scientific and Technical Information of China (English)

    ZHENG Xiang-qian; WANG Chen; XU Meng; YU Yang; YUN Xin-wei; JIA Yong-sheng; WEI Song-feng; REN Xiu-bao; GAO Ming

    2012-01-01

    Background Papillary thyroid carcinoma (PTC) represents one of the most frequent endocrine malignancies.Several factors have been found to be involved in determining the outcome of treatment for patients with PTC.Large tumor size,diagnosis at an early age,extra-thyroidal invasion,aggressive histological variants,and distant metastases are the most important determinants of a poor outcome.BRAFv600E mutation has been found to be a major genetic alteration in PTC.This study aimed to evaluate progression in patients with multifocal and solitary PTC.Methods We performed a retrospective study to analyze 368 patients with PTC who underwent surgery,including 282 patients with solitary PTC and 86 patients with multifocal PTC.The status of BRAFv600E mutation in all tumor foci from multifocal PTC was detected.Results Our study suggested that multifocal PTC was more related to lymph node metastasis and vascular invasion than solitary PTC.However,the distant metastasis rate and 10-year survival rate showed no difference between these two groups.The number of tumor foci did not affect progression of disease in multifocal PTC patients.Lymph node metastasis in multifocal PTC patients was associated with larger tumors,diagnosis at early stage,and extra-thyroidal invasion.Conclusion The status of BRAFv600E mutation was more frequent in multifocal PTC patients with lymph node metastasis and diagnosis at later age.

  16. Surface characterization of catalytically active metal, alloy, and compound films. Progress report, January 1, 1981-December 31, 1981

    Energy Technology Data Exchange (ETDEWEB)

    Vook, R. W.

    1981-06-01

    The work consists primarily of verification and confirmation of the Auger electron spectroscopy R-factor effect. The R-factor is a very sensitive measure of doublet Auger line shape changes or relative doublet line shifts. It can be used to identify epitaxial growth (in contrast to polycrystalline growth) and layer growth (in contrast to island or three dimensional growth). In these cases the R-factor oscillates periodically with added film thickness, for both thin and thick (approx. = 1500 A) films. The period equals the layer thickness. Since maxima in R are associated with a smooth surface and minima with a maximum in step density, R gives a measure of surface topography. An effect due to the substrate induced misfit strains on the Auger R-factor has been established. Studies were carried out on (111)Pd/(111)Cu, (111)Ag/(111)Cu, (111)Cu, and (111)Ag surfaces to establish the general validity of the results initially obtained with Pd. Experiments were begun to determine the effect of steps (as characterized by the R-factor) on the chemisorption of oxygen on Pd.

  17. Inert Electrodes Program: Characterization of the reaction layer or film on PNL (Pacific Northwest Laboratory) inert anodes: Progress Report for April-December 1989

    Energy Technology Data Exchange (ETDEWEB)

    Windisch, C.F. Jr.; Stice, N.D.

    1990-05-01

    This progress report addresses activities conducted at Pacific Northwest Laboratory (PNL) between April 1989 and December 1989 to characterize the reaction layer or film previously proposed by PNL to form on cermet anodes during the electrolytic production of aluminum in Hall-Heroult cells. Formation of this resistive film was thought to protect the cermet anode from corrosion reactions that would otherwise occur in the molten cryolite electrolyte. The results of potential-step studies, electrochemical impedance spectroscopy, and post-mortem microscopic analysis of polarized anodes suggest that the processes of corrosion of the metallic phase of the anode and the production of oxygen gas are separable and exhibit very different kinetic behavior. The corrosion reactions occur predominantly at low anode potentials, appear to show diffusion control, and may be related to the porosity of the anode. The oxygen production reaction is the predominant reaction above 2.2 V, exhibits activation control, occurs primarily on the surface of the anode, and is accompanied by an increase in surface roughness at higher current densities. Evidence presented in this report indicates that the production of oxygen shuts down the corrosion reactions, possibly through a pore-blocking mechanism. In addition, roughness effects may help explain some of the impedance relationships previously observed by PNL for these anodes. Although the present results do not rule out the formation of a protective layer or film, they strongly indicate mechanisms other than the formation of a macroscopic protective film for the apparent attenuation of corrosion reactions at typical operating current densities. 11 refs.

  18. LASER ABLATION/IONIZATION CHARACTERIZATION OF SOLIDS: FINAL PROGRESS REPORT OF THE STRATEGIC ENVIRONMENTAL RESEARCH AND DEVELOPMENT PROGRAM

    Science.gov (United States)

    The Department of Energy has undertaken the enormous task of remediating defense wastes and environmental insults which have occurred over 50 years of nuclear weapons production. It is abundantly clear that significant technology advances are needed to characterize, process, and ...

  19. [Progress in the study of syndromic hearing loss resulted from neural crest abnormalities].

    Science.gov (United States)

    Yalan, Liu; Hua, Zhang; Yong, Feng

    2014-11-01

    More than 400 types of syndromic hearing loss (SHL) have been reported so far, in which Waardenburg syndrome (WS), congenital microtia syndrome (CMS), and large vestibular aqueduct syndrome (LVAS) are the most common ones in clinic. However, it is difficult to study the genetic basis and pathogenesis of SHL in a systematical way because of the strong clinical and genetic heterogeneity of SHL. Dysfunction of neural crest cells (NCC), which are caused by the gene interaction network extended from SOX10 and PAX3, are relevant to the phenotype of WS, CMS and LVAS. Our previous study also confirmed that the gene network was involved in the pathogenesis of WS. In this review, we summarize research progress in the pathogenic mechanisms of SHL resulted from defects in neural crest decelopment, and provide the gene interaction network of neural crest abnormalities resulting in SHL, and hope to provide research ideas and theoretical basis for the systematical study on pathogenesis of common SHL. PMID:25567871

  20. Reactor Primary Coolant System Pipe Rupture Study. Progress report No. 32, July--December 1974

    International Nuclear Information System (INIS)

    The pipe rupture study is designed to extend the understanding of failure-causing mechanisms and to provide improved capability for evaluating reactor piping systems to minimize the probability of failures. Following a detailed review to determine the effort most needed to improve nuclear system piping (Phase I), analytical and experimental efforts (Phase II) were started in 1965. This progress report summarizes the recent accomplishments of a broad program in (a) basic fatigue studies focused on Elastic/Plastic ASME Code Design Rules, (b) at-reactor tests of the effect of primary coolant environment on the fatigue behavior of piping steels, and (c) studies directed at quantifying weld sensitization in T-304 stainless steel. (auth)

  1. Progress of Large-Scale Air-Sea Interaction Studies in China

    Institute of Scientific and Technical Information of China (English)

    蒲书箴; 赵进平; 于卫东; 赵永平; 杨波

    2004-01-01

    This paper summarizes the progress of large-scale air-sea interaction studies that has been achieved in China in the four-year period from July 1998 to July 2002, including seven aspects in the area of the air-sea interaction, namely air-sea interaction related to the tropical Pacific Ocean, monsoon-related air-sea interaction, air-sea interaction in the north Pacific Ocean, air-sea interaction in the Indian Ocean, air-sea interactions in the global oceans, field experiments, and oceanic cruise surveys. However more attention has been paid to the first and the second aspects because a large number of papers in the reference literature for preparing and organizing this paper are concentrated in the tropical Pacific Ocean, such as the ENSO process with its climatic effects and dynamics, and the monsoon-related air-sea interaction. The literature also involves various phenomena with their different time and spatial scales such as intraseasonal, annual, interannual, and interdecadal variabilities in the atmosphere/ocean interaction system, reflecting the contemporary themes in the four-year period at the beginning of an era from the post-TOGA to CLIVAR studies. Apparently, it is a difficult task to summarize the great progress in this area, as it is extracted from a large quantity of literature, although the authors tried very hard.

  2. Shielding benchmark experiments and sensitivity studies in progress at some European laboratories

    Energy Technology Data Exchange (ETDEWEB)

    Hehn, G. (Univ., Stuttgart); Mattes, M.; Matthes, W.; Nicks, R.; Rief, H.

    1975-10-01

    A 100 group standard library based on ENDF/B3 has been prepared by IKE and JRC. This library is used for the analysis of the current European and Japanese iron benchmark experiments. Further measurements are planned for checking the data sets for graphite, sodium and water. In a cooperation between the IKE and JRC groups coupled neutron-photon cross section sets will be produced. Point data are processed at IKE by the modular program system RSYST (CDC 6600) for elaborating the ENDFB data, whereas the JRC group, apart from using standard codes such as SUPERTOG 3, GAMLEG etc., has developed a series of auxiliary programs (IBM 360) for handling the DLC 2D and POPOP libraries and for producing the combined neutron-plus gamma library EL4 (119 groups). Sensitivity studies (in progress at IKE) make possible improvements in methods and optimization of calculation efforts for establishing group data. A tentative sensitivity study for a 3 dimensional MC approach is in progress at Ispra. As for nuclear data evaluation, the JRC group is calculating barium cross sections and their associated gamma spectra. 6 figures. (auth)

  3. Wall shear stress as a stimulus for carotid atherosclerotic plaque progression: An MRI-based CFD pilot study

    Science.gov (United States)

    Canton, Gador; Chiu, Bernard; Hatsukami, Tom; Kerwin, William; Yuan, Chun

    2010-11-01

    The aim of this study was to explore the hypothesis that intra-plaque hemorrhage, a feature associated with adverse outcomes and atherosclerotic plaque progression and destabilization, is more likely to occur in plaques with elevated levels of wall shear stress (WSS). We used multi-sequence in-vivo magnetic resonance imaging (MRI) to characterize ten human carotid atherosclerotic plaques and an MRI-based computational fluid dynamics (CFD) model to solve the equations governing the blood flow. Hemorrhage was detected within the necrotic core (intra-plaque hemorrhage) in five of these ten cases. WSS data were extracted from the results of the CFD simulations to compare patterns between the cases with and without hemorrhage. We computed the mean value of the WSS (for each time point of the cardiac cycle) at the region where a necrotic core was detected. The results from this pilot study indicate a possible link between the presence of hemorrhage within a lipid-rich necrotic core in human carotid atherosclerotic plaques and elevated levels of shear stress force acting on the luminal surface. Thus, elevated wall shear stress may be used as a high risk feature in advanced carotid atherosclerotic plaques.

  4. Progress in studies of Electron-Cloud-Induced Optics Distortions at CESRTA

    International Nuclear Information System (INIS)

    The Cornell Electron Storage Ring Test Accelerator (CesrTA) program has included extensive measurements of coherent betatron tune shifts for a variety of electron and positron beam energies, bunch population levels, and bunch train configurations. The tune shifts have been shown to result primarily from the interaction of the beam with the space-charge field of the beam-induced low energy electron cloud in the vacuum chamber. Comparison to several advanced electron cloud simulation program packages has allowed determination of the sensitivity of these measurements to physical parameters characterizing the synchrotron radiation flux, the production of photoelectrons on the vacuum chamberwall, the beam emittance, lattice optics, and the secondary-electron yield model. We report on progress in understanding the cloud buildup and decay mechanisms in magnetic fields and in field-free regions, addressing quantitatively the precise determination of the physical parameters of the modeling. Validation of these models will serve as essential input in the design of damping rings for future high-energy linear colliders.

  5. Progress in Studies of Electron-Cloud-Induced Optics Distortions at CesrTA

    International Nuclear Information System (INIS)

    The Cornell Electron Storage Ring Test Accelerator (CesrTA) program has included extensive measurements of coherent betatron tune shifts for a variety of electron and positron beam energies, bunch population levels, and bunch train configurations. The tune shifts have been shown to result primarily from the interaction of the beam with the space-charge field of the beam-induced low-energy electron cloud in the vacuum chamber. Comparison to several advanced electron cloud simulation codes has allowed determination of the sensitivity of these measurements to physical parameters characterizing the synchrotron radiation flux, the production of photo-electrons on the vacuum chamber wall, the beam emittance, lattice optics, and the secondary-electron yield model. We report on progress in understanding the cloud buildup and decay mechanisms in magnetic fields and in field-free regions, addressing quantitatively the precise determination of the physical parameters of the modeling. Validation of these models will serve as essential input in the design of damping rings for future high-energy linear colliders.

  6. Thiosaccharine disulfide: Synthesis, crystal structure, spectroscopic characterization and theoretical study

    Science.gov (United States)

    Ferullo, Ricardo M.; Granados, Alejandro; Lanterna, Anabel; Güida, Jorge A.; Piro, Oscar E.; Castellano, Eduardo E.; Dennehy, Mariana

    2013-01-01

    The title compound, (thiosaccharine disulfide), bis[1,1'dioxide-2,3-dihidro-1,2-benzoisothiazol]disulfide, (tsac)2 has been synthesized and fully characterized by UV-Visible, IR, Raman, 1H and 13C NMR spectroscopy elemental analysis and structural X-ray crystallography. A DFT theoretical study has been performed and good agreement between experimental and theoretical values of structural parameters and vibration frequencies have been achieved.

  7. Characterization of iPhone displays : a comparative study

    OpenAIRE

    Byshko, Roman; Li, Shujun

    2012-01-01

    This paper reports a comparative study on evaluating the performance of six display characterization models applied to mobile displays of four Apple iPhones belonging to three different models (3GS, 4 and 4S). The character- ization models evaluated include three PLCC (Piecewise Linear interpolation assuming Constant Chromaticity coordinates) models, the PLVC (Piecewise Linear interpolation assuming Variation in Chromaticity) model, Tamura- Tsumura-Miyake masking model with one principle comp...

  8. Progress of Dendrochronological Studies%树木年代学研究进展

    Institute of Scientific and Technical Information of China (English)

    王树芝

    2001-01-01

    Scientific dendrochronology was established by the American astronomer Dr. Douglass in the early 20th century; since then it has been applied by world scientists in many research fields. At present in Germany and U. S. A., there is the synthetic chronology tracing to 10,000 BP; in Japan, a synthetic chronology can trace to 4000 BC and more. Scientists have used dendrochronologies with long sequences in the study and dating of past cultures, as well as in researches on climates (including temperature and rainfall), ecological conditions, the cultivation of forests, plant diseases and insect pests,and environmental pollution. The present paper makes a brief summarization of the definition, principles and significance of chronology and the progress of dendrochronological studies at home and abroad, and points out problems in Chinese dendrodating and the measures of their solution.

  9. Bulgarian archaeomagnetic studies. A review of methodological progress and applications in archaeology

    International Nuclear Information System (INIS)

    Archaeomagnetic studies in Bulgaria have a long history and the well established secular variation curves of the three elements of the ancient geomagnetic field (declination, inclination and intensity) for the last 8000 years enable the dating of archaeological features of burnt clay, independently of other methods. The determination of ancient palaeointensity is the most difficult characteristic and requires very cautious evaluation of the suitability of the burnt clay material. Methodological progress in studying the suitability of the materials for archaeomagnetic investigations is overviewed. The main rock-magnetic methods and summary of the most common results are presented involving the archaeomagnetic practice in the palaeomagnetic laboratory in Sofia. In addition, supplementary information obtained by magnetic measurements, which can be helpful for archaeology, are discussed. An example of archaeomagnetic dating procedure is also presented. (author)

  10. Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study

    DEFF Research Database (Denmark)

    Viard, Jean-Paul; Souberbielle, Jean-Claude; Kirk, Ole;

    2011-01-01

    BACKGROUND:: We examined the association between vitamin D [25(OH)D] level and disease progression in HIV infection. METHODS:: Within the EuroSIDA study, 2000 persons were randomly selected for 25(OH)D measurement in stored plasma samples closest to study entry. 25(OH)D results were stratified into...... tertiles. Factors associated with 25(OH)D levels and associations of 25(OH) levels with subsequent risk of all-cause mortality, AIDS and non-AIDS events were analyzed. RESULTS:: Of 1985 persons with 25(OH)D levels available, 23.7% had 25(OH)D 30 ng/ml. At the time of 25(OH)D measurement, older persons...

  11. Differentiation and carcinogenesis: an integrated multilevel study of mechanisms from molecules to man. Progress report

    International Nuclear Information System (INIS)

    This study sought to identify and characterize mesenchymal progenitor cells (MPCs) in vitro, to identify the in vivo equivalent of the in vitro MPCs, and to determine the relationship between the presence or response of these cells both in vitro and eventually in vivo to altered proliferative capacity (in vitro cellular senescence, in vivo organismal aging) and altered susceptibility to carcinogenesis (frequency of in vitro neoplastic transformation and age-related frequency of in vivo cancer incidence). 16 refs

  12. Recent progress in the study of the next generation Internet in China.

    Science.gov (United States)

    Liu, Ying; Wu, Jianping; Wu, Qian; Xu, Ke

    2013-03-28

    The Internet has become a major part of the global communications infrastructure supporting modern-day socio-economic development, social progress and technological innovation. Invented 30 years ago, today the Internet is facing severe challenges. Many countries have funded research projects on the new-generation Internet, such as GENI, FIND, FIRE and CNGI, in an effort to solve these challenges. In addition, over the past few years, the networking research community has engaged in an ongoing conversation about how to move the Internet forward, and there are now two different approaches towards Internet research. The first approach is based on using the existing Internet architecture to solve the major technical challenges-this is called 'evolutionary' research. The other, which is called the 'clean slate', involves the design of an entirely new Internet architecture. In the first part of this paper, the basic features of the next generation Internet and its principal contradictions are analysed. Then a survey of recent progress in the study of the next generation Internet in China is discussed. Finally, the focus and direction for the next step in research are presented as based on fundamental research into the international next generation Internet architecture, and the many new innovative demands placed on Internet architecture in recent years. PMID:23419856

  13. Assessing progression of clinical reasoning through virtual patients: An exploratory study.

    Science.gov (United States)

    Forsberg, Elenita; Ziegert, Kristina; Hult, Håkan; Fors, Uno

    2016-01-01

    To avoid test-driven learning, there have been discussions regarding the use of more formative assessments in health care education to promote students' deep learning. Feedback is important in formative assessment, but many students ignore it; therefore, interventions should be introduced which stimulate them to reflect on the new knowledge. The aim for this study was to explore if Virtual Patient (VP)-based formative assessments, in connection with self-evaluations, had an impact on postgraduate pediatric nursing students' development of clinical reasoning abilities. Students' self-evaluations served as the basis for measuring progress. Data was analysed using deductive content analysis. The findings showed a clear progression of the clinical reasoning ability of the students. After the first assessment, the students described feelings of uncertainty and that their knowledge gaps were exposed. At the mid-course assessment the awareness of improved clinical reasoning was obvious and the students were more certain of knowing how to solve the VP cases. In the final assessment, self-efficacy was expressed. VP-based assessments, in connection with self-evaluations, early in the education resulted in a gain of students' own identification of the concept of clinical reasoning, awareness of what to focus on during clinical practice and visualised expected clinical competence. PMID:26482401

  14. Preliminary Hydrogeologic Characterization Results from the Wallula Basalt Pilot Study

    Energy Technology Data Exchange (ETDEWEB)

    B.P. McGrail; E. C. Sullivan; F. A. Spane; D. H. Bacon; G. Hund; P. D. Thorne; C. J. Thompson; S. P. Reidel; F. S. Colwell

    2009-12-01

    The DOE's Big Sky Regional Carbon Sequestration Partnership has completed drilling the first continental flood basalt sequestration pilot borehole to a total depth (TD) of 4,110 feet on the Boise White Paper Mill property at Wallula, Washington. Site suitability was assessed prior to drilling by the 2007-2008 acquisition, processing and analysis of a four-mile, five-line three component seismic swath, which was processed as a single data-dense line. Analysis of the seismic survey data indicated a composite basalt formation thickness of {approx}8,000 feet and absence of major geologic structures (i.e., faults) along the line imaged by the seismic swath. Drilling of Wallula pilot borehole was initiated on January 13, 2009 and reached TD on April 6, 2009. Based on characterization results obtained during drilling, three basalt breccia zones were identified between the depth interval of 2,716 and 2,910 feet, as being suitable injection reservoir for a subsequent CO2 injection pilot study. The targeted injection reservoir lies stratigraphically below the massive Umtanum Member of the Grande Ronde Basalt, whose flow-interior section possesses regionally recognized low-permeability characteristics. The identified composite injection zone reservoir provides a unique and attractive opportunity to scientifically study the reservoir behavior of three inter-connected reservoir intervals below primary and secondary caprock confining zones. Drill cuttings, wireline geophysical logs, and 31one-inch diameter rotary sidewall cores provided geologic data for characterization of rock properties. XRF analyses of selected rock samples provided geochemical characterizations of the rocks and stratigraphic control for the basalt flows encountered by the Wallula pilot borehole. Based on the geochemical results, the pilot borehole was terminated in the Wapshilla Ridge 1 flow of the Grande Ronde Basalt Formation. Detailed hydrologic test characterizations of 12 basalt interflow

  15. CT STUDY COMPARING SULCAL CHANGES AND THIRD VENTRICLE SIZE AS AGE PROGRESSES FROM 40 TO 80

    Directory of Open Access Journals (Sweden)

    Vinu C

    2014-09-01

    Full Text Available INTRODUCTION: Computerized tomography, also called CT combines a series of X-ray views taken from many different angles and computer processing to create cross-sectional images of the bones and soft tissues inside your body. It has brought about tremendous changes in the field of diagnostic and research medicine. Here CT is used to measure the various dimensions of 6 selected sulci of brain and third ventricle. With the recent advances in technology, sulcal pattern and development is being studied extensively to understand the functioning of brain. There is evidence of sulcal dimensional changes as age of an individual progress. This may be responsible for behavioral or intellectual changes in a individual. Through this study I intend to understand how the sulcal dimension may vary with the help of CT scans. 6 sulci were selected and their width was measured in 80 individuals between the age group of 40 and 80. Through statistical analysis the data will reveal any recognizable changes in the width of the selected sulcus with progression of age. The third ventricle size may also be influenced by the age of the individual. Using the help of CT scan I am intending to measure the dimensions of the third ventricle. Recent studies have shown that size and volume of the third ventricle have significant role in the geriatric population. AIMS AND OBJECTIVES: To study the age related changes in the width of left and right central sulcus, superior temporal sulcus, parieto-occipital sulcus and to study the age related changes in third ventricle depth, length and width through the use of CT scans. STUDY SETTINGS: A cross-sectional study comprising of 60 patients coming to the radiology department for the C T scan. The CT scans for the study were taken randomly between the ages of 40 to 80. RESULTS: The purpose of the study was to study the changes in the dimensions of sulci and the third ventricle of the brain. Hypothesis was that the sulcal width increases

  16. Progression of hip dysplasia in 40 police working dogs: a retrospective study

    International Nuclear Information System (INIS)

    The aim of the study was to evaluate the effects of progression of CHD and degenerative joint disease on a working capability of population of police working dogs. In the first part of the study, we reviewed the whole health documentation of all dogs and gathered all necessary radiographs of hip joints that were taken at first initial procurement. In the second part, clinical examination and radiographs of all dogs were taken 60 months after first examination and the progression of hip dysplasia was evaluated by the FCI scheme. All dogs were male, 35 German shepherds and 5 Rottweilers. The Norberg-Olsson angle in the first set of radiographs was 105.54 +/- 3.22 deg in 37 dogs without hip dysplasia and 100.17 +/- 2.99 deg in 3 dogs with initial mild dysplasia. In the second set of radiographs taken after 60 months of service the Norberg- Olsson angle was 105.60 +/- 3.67 deg in 23 dogs with no signs of hip dysplasia and 101.62 +/- 4.49 deg in 17 dogs with hip dysplasia. On the first set of radiographs, secondary degenerative changes were found in 3 dogs with initial mild dysplasia (7.5 %) and in 14 dogs (35 %) on second radiographs. The position of the centre of the femoral head on first radiographs was outside of dorsal acetabular rim in 25 (31.25 %) of estimated hip joints (n = 80); at the level of the rim in 30 (37.5 %) and inside in 25 (31.25 %). On second radiographs it was outside in 41 (51.25 %); at the level of the rim in 26 (32.5 %); and inside in 13 (31.25 %) of estimated hip joints. The mean femoral angle of inclination for all 40 dogs was 132.50 +/- 4.39? deg . If it has occured, the increase in degree of hip dysplasia was generally more than one degree. In 57.5 % of cases hip dysplasia was not determined on second radiographs. All dogs with some degree of hip dysplasia were German shepherds, but only one of them had clinical symptoms connected to CHD. The progression of hip dysplasia did not correlate with work period of the dogs, and has no influence on

  17. [Paleoclimatology studies for Yucca Mountain site characterization]. Final report

    International Nuclear Information System (INIS)

    This report consists of two separate papers: Fernley Basin studies; and Influence of sediment supply and climate change on late Quaternary eolian accumulation patterns in the Mojave Desert. The first study involved geologic mapping of late Quaternary sediments and lacustrine features combined with precise control of elevations and descriptions of sediments for each of the major sedimentary units. The second paper documents the response of a major eolian sediment transport system in the east-central Mojave Desert: that which feeds the Kelso Dune field. Information from geomorphic, stratigraphic, and sedimentologic studies of eolian deposits and landforms is combined with luminescence dating of these deposits to develop a chronology of periods of eolian deposition. Both studies are related to site characterization studies of Yucca Mountain and the forecasting of rainfall patterns possible for the high-level radioactive waste repository lifetime

  18. Progress in Finite Time Thermodynamic Studies for Internal Combustion Engine Cycles

    Directory of Open Access Journals (Sweden)

    Yanlin Ge

    2016-04-01

    Full Text Available On the basis of introducing the origin and development of finite time thermodynamics (FTT, this paper reviews the progress in FTT optimization for internal combustion engine (ICE cycles from the following four aspects: the studies on the optimum performances of air standard endoreversible (with only the irreversibility of heat resistance and irreversible ICE cycles, including Otto, Diesel, Atkinson, Brayton, Dual, Miller, Porous Medium and Universal cycles with constant specific heats, variable specific heats, and variable specific ratio of the conventional and quantum working fluids (WFs; the studies on the optimum piston motion (OPM trajectories of ICE cycles, including Otto and Diesel cycles with Newtonian and other heat transfer laws; the studies on the performance limits of ICE cycles with non-uniform WF with Newtonian and other heat transfer laws; as well as the studies on the performance simulation of ICE cycles. In the studies, the optimization objectives include work, power, power density, efficiency, entropy generation rate, ecological function, and so on. The further direction for the studies is explored.

  19. Recent progress in ionospheric earthquake precursor study in China: A brief review

    Science.gov (United States)

    Le, Huijun; Liu, Jing; Zhao, Biqiang; Liu, Libo

    2015-12-01

    The study of ionospheric anomaly variation before large earthquakes has attracted the attention of geophysicists for many years. This is primarily because ionospheric anomaly variation has been considered to constitute one possible method to identify earthquake precursors. Since China covers several major earthquake zones, it is critical for Chinese scientists to study possible ionospheric earthquake precursors. In this report, we provide a brief summary of recent progress in the study of ionospheric earthquake precursors mainly from Chinese mainland researchers, as well as some other scientists. This report focuses on: (1) some case studies of ionospheric abnormal behaviors before some great earthquakes around the world (e.g., M7.9 Wenchuan Earthquake, M9.0 Tohoku-Oki Earthquake, M7.0 Haiti Earthquake); and (2) some statistical characteristics of ionospheric anomalies before earthquakes, including their temporal and spatial distributions, and the relationship with the forthcoming earthquake. The above-mentioned studies may provide some new and beneficial insights for the future study of ionospheric earthquake precursors.

  20. Study of the molecular basis for radiation mutagenesis. Final progress report

    International Nuclear Information System (INIS)

    A novel approach has been taken to the study of radiobiological effects at the molecular level. This method is aimed at correlating a particular radiation product with its biological effect. The investigation involved four stages: (1) separation, isolation and characterization of the radiation products of nucleic acid components; (2) methods for synthesis of these products to allow sufficient quantities for stages 3 and 4; (3) examination of the biological effects of the radiation products in vivo and in vitro; and (4) study of the molecular mechanisms related to an observed biological effect

  1. Global guidance on environmental life cycle impact assessment indicators: Progress and case study

    DEFF Research Database (Denmark)

    Frischknecht, Rolf; Fantke, Peter; Tschümperlin, Laura;

    2016-01-01

    Purpose The life cycle impact assessment (LCIA) guidance flagship project of the United Nations Environment Programme (UNEP)/Society of Environmental Toxicology and Chemistry (SETAC) Life Cycle Initiative aims at providing global guidance and building scientific consensus on environmental LCIA...... warming, fine particulate matter emissions, water use and land use, plus cross-cutting issues and LCAbased footprints. The paper reports the process and progress and specific results obtained in the different task forces (TFs). Additionally, a rice LCA case study common to all TF has been developed. Three...... practicality of the finally recommended impact category indicators. Results and discussion The global warming TF concludes that analysts should explore the sensitivity of LCA results to metrics other than GWP. The particulate matter TF attained initial guidance of how to include health effects from PM2...

  2. CTR plasma engineering studies. Annual progress report, 1 December 1984-30 November 1985

    International Nuclear Information System (INIS)

    Work under this project is focused on plasma engineering developments in support of fusion reactor studies. The work described in this annual progress report covers a variety of topics ranging from plasma transport modelling for compact tori to radiation heating of the first wall in a fusion device. Sections 2 and 3 decribe computer codes developed for use with field-reversed configurations such as spheromaks and field-reversed mirrors. Section 4 presents an evaluation of the feasibility of heating a RFP-type reactor to ignition with ohmic current input alone. Sections 5 and 6 describe new work that has been initiated on optimal control theory for fusion reactors. Sections 7 to 9 discuss recent results on alpha-particle transport, instabilities, and diagnostics. In the final section, methods for analysis of the poloidal variation in the thermal wall loading of a tokamak reactor are discussed and some typical results are presented

  3. Stress CT myocardial perfusion imaging in coronary artery disease: preliminary study progress

    International Nuclear Information System (INIS)

    Coronary artery disease (CAD) is the result of the imbalance between coronary blood flow and myocardial oxygen demand. Using stenosis of coronary artery alone to diagnose CAD could not accurately reflect the status of myocardial ischemia, nor make accurate warning of ischemic cardiac events. Stress CT myocardial perfusion imaging (stress CT-MPI) can assess the myocardial blood flow qualitatively and quantitatively and detect the myocardial microcirculation and myocardial viability, which can predict the occurrence of cardiac events and provide an objective basis for early intervention. This review provided an overview of the stress CT-MPI, including its detection principles, methods, and clinical study progress in the patients with coronary artery disease. (authors)

  4. Institute for Fusion Studies progress report, November 1, 1989--October 31, 1990

    International Nuclear Information System (INIS)

    During the past year significant progress was made in carrying out theoretical investigations pursuant to the scientific mission of the Institute. These achievements may be approximately classified in terms of the following research categories (often with considerable overlap); tokamak MHD studies, turbulence theory and plasma transport, computational plasma physics, stability theory, mathematical physics, advanced ideas, and space plasma physics-related problems. An overview of this work is contained in this report. This paper contains a list of the numerous scientific papers published in technical journals by IFS scientists during the past year. Also, detailed summaries of IFS Reports written during FY 90 are given in abstract form in Appendix A of this report. It is worth noting that, in addition to the many research publications, two lengthy review articles were written during the past year at the IFS: one on nonlinear drift waves and transport in magnetized plasmas, and the other an introduction to bifurcation theory

  5. Studies of heavy ion reactions and transuranic nuclei. Progress report, September 1, 1985-August 31, 1986

    International Nuclear Information System (INIS)

    Progress is reported of research directed to explore nuclear relaxation and transport phenomena induced in heavy-ion collisions, in the range from near-barrier energies to more than 20 MeV per nucleon above the interaction barrier. Transport processes studied include the redistribution of kinetic energy of relative motion and of linear momentum as well as the gradual relaxation of various conditions of a colliding heavy-ion system, initially far from thermodynamic equilibrium, towards a uniform population of phase space. And, finally, they include the stochastic, equilibrium, and nonequilibrium patterns of nuclear disintegration. The group activities range from design of hardware to theoretical modeling. 112 refs., 56 figs., 6 tabs

  6. Study of electrons photoemitted from field emission tips. Progress report, July 1, 1979-March 1, 1980

    International Nuclear Information System (INIS)

    Photo-induced field emission is a technique which studies electrons that have been photoemitted from a field emission tip. This new experimental method promises to combine the proven utility of both field emission and photoemission for investigating the electronic states near a metal surface. The primary objective of the research being performed is to investigate photo-induced field emitted electrons using a tuneable cw dye laser. To fully exploit this continuously tuneable photon source, a differential energy analyzer is being constructed to allow energy resolved measurements of the photo-field emitted electrons. This report describes the progress made in implementing experiments on photo-induced field emission from July 1979 to March 1980

  7. Skin autofluorescence is associated with the progression of chronic kidney disease: a prospective observational study.

    Directory of Open Access Journals (Sweden)

    Kenichi Tanaka

    Full Text Available BACKGROUND: Advanced glycation end product (AGE accumulation is thought to be a measure of cumulative metabolic stress that has been reported to independently predict cardiovascular disease in diabetes and renal failure. The aim of this study was to evaluate the association between AGE accumulation, measured as skin autofluorescence, and the progression of renal disease in pre-dialysis patients with chronic kidney disease (CKD. METHODS: Skin autofluorescence was measured noninvasively with an autofluorescence reader at baseline in 449 pre-dialysis patients with CKD. The primary end point was defined as a doubling of serum creatinine and/or need for dialysis. RESULTS: Thirty-three patients were lost to follow-up. Forty six patients reached the primary end point during the follow-up period (Median 39 months. Kaplan-Meier analysis showed a significantly higher risk of development of the primary end points in patients with skin autofluorescence levels above the optimal cut-off level of 2.31 arbitrary units, derived by receiver operator curve analysis. Cox regression analysis revealed that skin autofluorescence was an independent predictor of the primary end point, even after adjustment for age, gender, smoking history, diabetes, estimated glomerular filtration rate and proteinuria (adjusted hazard ratio 2.58, P = 0.004. CONCLUSIONS: Tissue accumulation of AGEs, measured as skin autofluorescence, is a strong and independent predictor of progression of CKD. Skin autofluorescence may be useful for risk stratification in this group of patients; further studies should clarify whether AGE accumulation could be one of the therapeutic targets to improve the prognosis of CKD.

  8. CSF biomarkers associated with disease heterogeneity in early Parkinson's disease: the Parkinson's Progression Markers Initiative study.

    Science.gov (United States)

    Kang, Ju-Hee; Mollenhauer, Brit; Coffey, Christopher S; Toledo, Jon B; Weintraub, Daniel; Galasko, Douglas R; Irwin, David J; Van Deerlin, Vivianna; Chen-Plotkin, Alice S; Caspell-Garcia, Chelsea; Waligórska, Teresa; Taylor, Peggy; Shah, Nirali; Pan, Sarah; Zero, Pawel; Frasier, Mark; Marek, Kenneth; Kieburtz, Karl; Jennings, Danna; Tanner, Caroline M; Simuni, Tanya; Singleton, Andrew; Toga, Arthur W; Chowdhury, Sohini; Trojanowski, John Q; Shaw, Leslie M

    2016-06-01

    The development of biomarkers to predict the progression of Parkinson's disease (PD) from its earliest stage through its heterogeneous course is critical for research and therapeutic development. The Parkinson's Progression Markers Initiative (PPMI) study is an ongoing international multicenter, prospective study to validate biomarkers in drug-naïve PD patients and matched healthy controls (HC). We quantified cerebrospinal fluid (CSF) alpha-synuclein (α-syn), amyloid-beta1-42 (Aβ1-42), total tau (t-tau), and tau phosphorylated at Thr181 (p-tau) in 660 PPMI subjects at baseline, and correlated these data with measures of the clinical features of these subjects. We found that CSF α-syn, t-tau and p-tau levels, but not Aβ1-42, were significantly lower in PD compared with HC, while the diagnostic value of the individual CSF biomarkers for PD diagnosis was limited due to large overlap. The level of α-syn, but not other biomarkers, was significantly lower in PD patients with non-tremor-dominant phenotype compared with tremor-dominant phenotype. In addition, in PD patients the lowest Aβ1-42, or highest t-tau/Aβ1-42 and t-tau/α-syn quintile in PD patients were associated with more severe non-motor dysfunction compared with the highest or lowest quintiles, respectively. In a multivariate regression model, lower α-syn was significantly associated with worse cognitive test performance. APOE ε4 genotype was associated with lower levels of Aβ1-42, but neither with PD diagnosis nor cognition. Our data suggest that the measurement of CSF biomarkers in early-stage PD patients may relate to disease heterogeneity seen in PD. Longitudinal observations in PPMI subjects are needed to define their prognostic performance. PMID:27021906

  9. Studies of relativistic heavy ion collisions: Annual progress report, July 16, 1987--July 31, 1988

    International Nuclear Information System (INIS)

    The following reports outline the progress of our two-fold program in relativistic heavy ion studies. First of all, a signature for new phenomena in hot, dense nuclear matter may be possible by the observation of lepton pairs in heavy ion collisions. Our experiments have already shown the important sources of lepton pairs from pion annihilation. A second signature of possible new phenomena was a study of lambda polarization in heavy ion collisions. Our group was part of a collaborative effort in the study using polarized beams and the results to date are presented here. In this connection, our group undertook to study in a preliminary way the production of the lambda hyperon in silicon-aluminum collisions at the AGS. Future experiments on hyperon studies in general will be done in collaboration with the BNL 810 collaboration. The Hopkins group has also participated in experiments on subthreshold production of K-mesons and antiprotons at the Bevalac. Finally, an effort to employ Cerenkov ring-imaging techniques to identify lepton pairs within the high flux of protons and mesons from the heavy ion collisions has been initiated at LBL

  10. Recent progress in the feasibility study for the first nuclear power plant in Indonesia

    International Nuclear Information System (INIS)

    In September 1989 the Indonesian Government decided to perform a Nuclear Power Plant feasibility study, including a comprehensive investigation of Muris site. This presentation reports on the progress to date in the two main components of this study: (a) the non-site studies, covering energy economics, financing, technical and safety aspects, the fuel cycle and waste management as well as general management aspects, and (b) site and environmental studies, covering field investigations, assessment of site selection, site qualification/evaluation, environmental, socio-economic and cultural impacts. The study is carried out under a comprehensive quality assurance programme developed by a consultancy company - NEWJEC Inc., which compiles with IAEA recommendations and was approved by BATAN. A summary of the main results, recommendations and general conclusions is presented. It is estimated that the total investment for the construction of 2 x 900 MWe or 3 x 600 MWe class Nuclear Power Plant units would be around US$7 to US$9 billion. 8 tabs

  11. Progress in nano-electro optics characterization of nano-optical materials and optical near-field interactions

    CERN Document Server

    Ohtsu, Motoichi

    2005-01-01

    This volume focuses on the characterization of nano-optical materials and optical-near field interactions. It begins with the techniques for characterizing the magneto-optical Kerr effect and continues with methods to determine structural and optical properties in high-quality quantum wires with high spatial uniformity. Further topics include: near-field luminescence mapping in InGaN/GaN single quantum well structures in order to interpret the recombination mechanism in InGaN-based nano-structures; and theoretical treatment of the optical near field and optical near-field interactions, providing the basis for investigating the signal transport and associated dissipation in nano-optical devices. Taken as a whole, this overview will be a valuable resource for engineers and scientists working in the field of nano-electro-optics.

  12. A comparative study of two prediction models for brain tumor progression

    Science.gov (United States)

    Zhou, Deqi; Tran, Loc; Wang, Jihong; Li, Jiang

    2015-03-01

    MR diffusion tensor imaging (DTI) technique together with traditional T1 or T2 weighted MRI scans supplies rich information sources for brain cancer diagnoses. These images form large-scale, high-dimensional data sets. Due to the fact that significant correlations exist among these images, we assume low-dimensional geometry data structures (manifolds) are embedded in the high-dimensional space. Those manifolds might be hidden from radiologists because it is challenging for human experts to interpret high-dimensional data. Identification of the manifold is a critical step for successfully analyzing multimodal MR images. We have developed various manifold learning algorithms (Tran et al. 2011; Tran et al. 2013) for medical image analysis. This paper presents a comparative study of an incremental manifold learning scheme (Tran. et al. 2013) versus the deep learning model (Hinton et al. 2006) in the application of brain tumor progression prediction. The incremental manifold learning is a variant of manifold learning algorithm to handle large-scale datasets in which a representative subset of original data is sampled first to construct a manifold skeleton and remaining data points are then inserted into the skeleton by following their local geometry. The incremental manifold learning algorithm aims at mitigating the computational burden associated with traditional manifold learning methods for large-scale datasets. Deep learning is a recently developed multilayer perceptron model that has achieved start-of-the-art performances in many applications. A recent technique named "Dropout" can further boost the deep model by preventing weight coadaptation to avoid over-fitting (Hinton et al. 2012). We applied the two models on multiple MRI scans from four brain tumor patients to predict tumor progression and compared the performances of the two models in terms of average prediction accuracy, sensitivity, specificity and precision. The quantitative performance metrics were

  13. Synthesis and Characterization of Organotin Containing Copolymers: Reactivity Ratio Studies

    Directory of Open Access Journals (Sweden)

    Mohamed H. El-Newehy

    2010-03-01

    Full Text Available Organotin monomers containing dibutyltin groups – dibutyltin citraconate (DBTC as a new monomer and dibutyltin maleate (DBTM – were synthesized. Free radical copolymerizations of the organotin monomers with styrene (ST and butyl acrylate (BA were performed. The overall conversion was kept low (≤15% wt/wt for all studied samples and the copolymers composition was determined from tin analysis using the Gillman and Rosenberg method. The reactivity ratios were calculated from the copolymer composition using the Fineman-Ross (FR method. The synthesized monomers were characterized by elemental analysis, 1H-, 13C-NMR and FTIR spectroscopy.

  14. Defining natural history: assessment of the ability of college students to aid in characterizing clinical progression of Niemann-Pick disease, type C.

    Directory of Open Access Journals (Sweden)

    Jenny Shin

    Full Text Available Niemann-Pick Disease, type C (NPC is a fatal, neurodegenerative, lysosomal storage disorder. It is a rare disease with broad phenotypic spectrum and variable age of onset. These issues make it difficult to develop a universally accepted clinical outcome measure to assess urgently needed therapies. To this end, clinical investigators have defined emerging, disease severity scales. The average time from initial symptom to diagnosis is approximately 4 years. Further, some patients may not travel to specialized clinical centers even after diagnosis. We were therefore interested in investigating whether appropriately trained, community-based assessment of patient records could assist in defining disease progression using clinical severity scores. In this study we evolved a secure, step wise process to show that pre-existing medical records may be correctly assessed by non-clinical practitioners trained to quantify disease progression. Sixty-four undergraduate students at the University of Notre Dame were expertly trained in clinical disease assessment and recognition of major and minor symptoms of NPC. Seven clinical records, randomly selected from a total of thirty seven used to establish a leading clinical severity scale, were correctly assessed to show expected characteristics of linear disease progression. Student assessment of two new records donated by NPC families to our study also revealed linear progression of disease, but both showed accelerated disease progression, relative to the current severity scale, especially at the later stages. Together, these data suggest that college students may be trained in assessment of patient records, and thus provide insight into the natural history of a disease.

  15. Characterization and Thermodynamics Studies of Feldspar and Feldspathoid Minerals

    Science.gov (United States)

    Rudow, M.; Lilova, K.

    2015-12-01

    The application of thermal analysis and calorimetry for the studies of minerals has a history as long as the existence of the thermal methods themselves. New advanced calorimetric techniques have been developed for more accurate characterization of both bulk and nano materials thus impacting their design, processing, and applications. TG-DTA and TG-DSC are used to characterize the composition of complex minerals (e.g. [KxNa1-x(AlSi3)O8]) based on the weight changes and phase transformations observed with temperature increase. Additionally, those techniques allow to determine the quantity of the different types of water contained in natural feldspars and feldspathoids (absorbed, interlayer, structural). The results for several clays will be discussed. The geochemical properties and thermal stability of another class of minerals - aluminosilicate frameworks (alkali sodalities, natrolites, etc.) as related to high-level nuclear waste treatment facilities, radioactive waste storage and management were studied. The natural sodalite Na8[Al6Si6O24]Cl2 and similar frameworks with different anions are part of sodium-aluminosilicate (NAS) low activity radioactive waste produced during steam reforming process treatment. The enthalpies and entropies of formation and the hydration enthalpies of the above-mentioned feltspathoids are obtained and the effect of the different cations and anions on the thermodynamic stability was studied. The results will allow to predict the long term behavior of the compounds in the environment under different conditions.

  16. Characterization and Beneficiation Studies of a Low Grade Bauxite Ore

    Science.gov (United States)

    Rao, D. S.; Das, B.

    2014-10-01

    A low grade bauxite sample of central India was thoroughly characterized with the help of stereomicroscope, reflected light microscope and electron microscope using QEMSCAN. A few hand picked samples were collected from different places of the mine and were subjected to geochemical characterization studies. The geochemical studies indicated that most of the samples contain high silica and low alumina, except a few which are high grade. Mineralogically the samples consist of bauxite (gibbsite and boehmite), ferruginous mineral phases (goethite and hematite), clay and silicate (quartz), and titanium bearing minerals like rutile and ilmenite. Majority of the gibbsite, boehmite and gibbsitic oolites contain clay, quartz and iron and titanium mineral phases within the sample as inclusions. The sample on an average contains 39.1 % Al2O3 and 12.3 % SiO2, and 20.08 % of Fe2O3. Beneficiation techniques like size classification, sorting, scrubbing, hydrocyclone and magnetic separation were employed to reduce the silica content suitable for Bayer process. The studies indicated that, 50 % by weight with 41 % Al2O3 containing less than 5 % SiO2 could be achieved. The finer sized sample after physical beneficiation still contains high silica due to complex mineralogical associations.

  17. Theoretical studies of atomic transitions. Progress report, March 15, 1982-March 14, 1985

    International Nuclear Information System (INIS)

    Allowed and forbidden transitions have been studied for a number of atomic systems, of interest in fusion research, using the multiconfiguration Hartree-Fock method with relativistic corrections in the Breit-Pauli approximation. To perform these studies, an atomic structure software package has been designed with computers such as the VAX 11/780 in mind. Numerical procedures are being developed which will extend the program capability to continuum functions which arise in photo-ionization calculations. Extensive studies have been performed of fine-structure splittings and transition rates (E2 and M1) for the ground configurations of the Boron, Nitrogen and Oxygen sequences within the MCHF + BP approximation. Allowed 2s → 2p transitions for the latter were also considered. Calculations for the Carbon sequence are in progress. In an attempt to improve the level of accuracy for few electron systems, programs were developed which would include the mass polarization correction, arising from the finite mass of the nucleus. A revised MCHF program has removed the restriction on the l-quantum number. Some preliminary results for He and Li II have been obtained. Unlike many studies which report results for an isoelectronic sequence, thereby providing fragments of information about a number of spectra, moderately accurate calculations of energy levels and lifetimes were performed for a large portion of a single spectrum. Some 30 quartet levels of Be II were determined. This lead to the identification of a number of lines that had been observed in fast-ion beam experiments

  18. Determinants of Timely Completion: The Impact of Bachelor's Degree Programme Characteristics and Student Motivation on Study Progress

    Science.gov (United States)

    Suhre, Cor J. M.; Jansen, Ellen P. W. A.; Torenbeek, M.

    2013-01-01

    Timely completion of university degree programmes is a topic of growing concern to higher education institutions and their students. This paper reports on a study about the impact of degree programme characteristics and student motivation on study progress. The setting for the study is a Dutch law school. Data on degree programme characteristics,…

  19. Determinants of timely completion : the impact of Bachelor's degree programme characteristics and student motivation on study progress

    NARCIS (Netherlands)

    Suhre, Cor J. M.; Jansen, Ellen P. W. A.; Torenbeek, M.

    2013-01-01

    Timely completion of university degree programmes is a topic of growing concern to higher education institutions and their students. This paper reports on a study about the impact of degree programme characteristics and student motivation on study progress. The setting for the study is a Dutch law s

  20. Nutritional Status is Associated with Faster Cognitive Decline and Worse Functional Impairment in the Progression of Dementia: The Cache County Dementia Progression Study1.

    Science.gov (United States)

    Sanders, Chelsea; Behrens, Stephanie; Schwartz, Sarah; Wengreen, Heidi; Corcoran, Chris D; Lyketsos, Constantine G; Tschanz, JoAnn T

    2016-02-27

    Nutritional status may be a modifiable factor in the progression of dementia. We examined the association of nutritional status and rate of cognitive and functional decline in a U.S. population-based sample. Study design was an observational longitudinal study with annual follow-ups up to 6 years of 292 persons with dementia (72% Alzheimer's disease, 56% female) in Cache County, UT using the Mini-Mental State Exam (MMSE), Clinical Dementia Rating Sum of Boxes (CDR-sb), and modified Mini Nutritional Assessment (mMNA). mMNA scores declined by approximately 0.50 points/year, suggesting increasing risk for malnutrition. Lower mMNA score predicted faster rate of decline on the MMSE at earlier follow-up times, but slower decline at later follow-up times, whereas higher mMNA scores had the opposite pattern (mMNA by time β= 0.22, p = 0.017; mMNA by time2 β= -0.04, p = 0.04). Lower mMNA score was associated with greater impairment on the CDR-sb over the course of dementia (β= 0.35, p <  0.001). Assessment of malnutrition may be useful in predicting rates of progression in dementia and may provide a target for clinical intervention. PMID:26967207

  1. Foxp3 promoter polymorphism (rs3761548) in breast cancer progression: a study from India.

    Science.gov (United States)

    Jahan, Parveen; Ramachander, V R Vinish; Maruthi, G; Nalini, S; Latha, K Prasanna; Murthy, T S R

    2014-04-01

    Breast cancer is the most common female neoplasm that drives the transformation of normal mammary epithelial cells into highly malignant derivatives. Forkhead Box Protein3 (Foxp3), a tumor suppressor/immunomodulatory gene, which controls the function of Treg cells and oncogenes is down regulated in breast cancer. The main aim of the present study is to evaluate the potential influence of Foxp3-3279 C>A polymorphism (rs3761548) and -2383 C>T polymorphism (rs3761549) in 202 breast cancer patients and 130 normal healthy women of Indian origin. The genotypes were determined using ARMS-PCR for rs3761548 and PCR-RFLP method for rs3761549 using specific primers. The results revealed lack of association of these two polymorphisms with breast cancer susceptibility. However, with respect to AA genotype of rs3761548, we found highly significant association with the advanced stage (T3-4) of the tumor (OR = 3.90; 95% confidence interval (CI) = 1.56-9.70; p = 0.03). Stratified data also revealed an association of homozygous mutant genotype with advanced stage of tumor in premenopausal women (OR = 4.56; 95% CI = 1.07-19.38; p = 0.04) with disease duration of <6 months (OR =  .10; 95% CI = 1.80-20.50; p = 0.002) suggestive of modulating effect of rs3761548 in tumor progression. We conclude that Foxp3 rs37161548 has a potential to be a polymorphic marker for tumor progression in premenopausal breast cancer patients in Indian women. PMID:24338714

  2. Characterization of artificial spherical particles for DEM validation studies

    Institute of Scientific and Technical Information of China (English)

    Ignazio Cavarretta; Catherine O'Sullivan; Erdin Ibraim; Martin Lings; Simon Hamlin; David Muir Wood

    2012-01-01

    This paper describes a study in which advanced particle-scale characterization was carried out on spherical particles that can be used in experimental tests to validate discrete element method (DEM) simulations,Two types of particle,alkaline and borosilicate glass heads,made from two different materials,were considered.The particle shape,stiffness,contact friction properties and surface roughness were measured.The influences of hardness and roughness on the mechanical response of the particles were carefully considered.Compared to the alkaline beads,the borosilicate beads were more spherical and more uniform in size,and they exhibited mechanical characteristics closer to natural quartz sand.While only two material types were studied,the work has the broader implication as a methodology for selecting particles suitable for use in DEM studies and the key parameters that should be considered in the selection process are highlighted.

  3. Characterizing dense suspensions: two case studies from the pharmaceutical industry

    Science.gov (United States)

    Goldfarb, David J.; Khawaja, Nazia; Kazakevich, Irina; Bhattacharjee, Himanshu; Heslinga, Michael; Dalton, Chad

    2015-11-01

    Liquid suspensions of Active Pharmaceutical Ingredient powders are present as pharmaceutical dosage forms in the form of oral suspensions and injectables. We present two case studies, both dense (~ 30-40%) suspensions, in which the physical characterization of the product, specifically, particle size & shape and rheology were key to understanding the key product attributes as pertaining to the manufacturing process and to patient administration. For the one case study, an oral suspension, identifying variations in particle morphology during the wet milling of the product was key to the product understanding necessary to modify the milling process. Rheological measurements were applied as well. For the second case study, an injectable, results from different particle size measurement techniques and rheological measurements indicated the possibility of flocculation in a formulation. Additionally, measurements were obtained to assess the ``injectability'' of the product via rheometer and texture analyzer measurements and Poiseuille flow modeling. As a result, the relevant shear rate regime for this drug product administration was identified.

  4. Monitoring Progress in Child Poverty Reduction: Methodological Insights and Illustration to the Case Study of Bangladesh

    Science.gov (United States)

    Roche, Jose Manuel

    2013-01-01

    Important steps have been taken at international summits to set up goals and targets to improve the wellbeing of children worldwide. Now the world also has more and better data to monitor progress. This paper presents a new approach to monitoring progress in child poverty reduction based on the Alkire and Foster adjusted headcount ratio and an…

  5. Spectroscopic studies of the progress of humification processes in humic acid extracted from sewage sludge

    Science.gov (United States)

    Polak, J.; Sułkowski, W. W.; Bartoszek, M.; Papież, W.

    2005-06-01

    The humic acids extracted from sludge collected from the digestion chamber and the sludge drying beds were studied. The sludge samples were collected, dried and humic acids were extracted. The progress of the humification processes was studied with EPR, IR and NMR spectroscopic methods. For extracted humic acids, concentration of free radicals and g factor was determined with EPR. The presence of characteristic functional groups was confirmed with IR and NMR spectroscopy. To study the changes in content of the elements, the elemental analysis was performed to determine the percentage of carbon, hydrogen, nitrogen, sulfur and oxygen. Taking all the obtained results into account it was found that on the sewage drying beds, humification processes take place in the sludge. In the first two weeks when the sludge on the drying beds an intensive enrichment of humic acids in free radicals takes place. This is the result of the intensive humification process course after the stage in the fermentation chamber where the mesophilic fermentation takes place. Moreover, the humidity of sludge influences the intensive development of free radical concentration at the beginning of the storing period, whereas the humification processes still continue.

  6. Progress report on SYVAC chemical speciation modelling studies during 1983/4

    International Nuclear Information System (INIS)

    This report summarises progress made on the SYVAC (System Variability Analysis program) chemical speciation project during 1983-4. Chemical speciation is defined and its importance in the SYVAC approach to Radioactive Waste Management is discussed. Computer modelling of chemical equilibria is described and the two programs presently operational at UWIST - SOLMNQ and MINEQL - are compared and discussed in detail. In view of the shortcomings of the databases supplied with these programs, a new database of equilibrium constants has been compiled containing 483 aqueous species and 329 solid phases, including data for the radionuclides uranium, plutonium, americium, neptunium and thorium. The collaborative work with AERE, Harwell, is reported. A leaching experiment carried out at Harwell has been modelled using the chemical speciation programs. The results for uranium, plutonium, americium and neptunium, are presented. However, the experimental data provided by AERE is insufficient for accurate simulations. Chemical speciation studies relating to specific sites require accurate characterisation of the groundwater, i.e. chemical composition, Eh and pH. In the absence of such information, preliminary studies have been made using an average granite groundwater. The results of these studies are presented and include solubility and speciation plots for uranium, plutonium, thorium and neptunium. The future aims of the project are discussed. (author)

  7. Progress in rapid climate changes and their modeling study in millennial and centennial scales

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Rapid climate change at millennial and centennial scales is one of the most important aspects in paleoclimate study.It has been found that rapid climate change at millennial and centennial scales is a global phenomenon during both the glacial age and the Holocene with amplitudes typical of geological or astronomical time-scales.Simulations of glacial and Holocene climate changes have demonstrated the response of the climate system to the changes of earth orbital parameter and the importance of variations in feedbacks of ocean,vegetation,icecap and greenhouse gases.Modeling experiments suggest that the Atlantic thermohaline circulation was sensitive to the fresh water input into the North Atlantic and was closely related to the rapid climate changes during the last glacial age and the Holocene.Adopting the Earth-system models of inter mediate complexity (EMICs),CLIMBER-2,the response of East Asian climate change to Dansgaard/Oeschger and Heinrich events during the typical last glacial period (60 ka B.P.-20 ka B.P.) and impacts of ice on the Tibetan plateau on Holocene climate change were stimulated,studied and revealed.Further progress of paleoclimate modeling depends on developing finer-grid models and reconstructing more reliable boundary conditions.More attention should be paid on the study of mechanisms of abrupt climatic changes as well as regional climate changes in the background of global climate change.

  8. Recent progress of deep seismic experiments and studies of crustal structure in northern South China Sea

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The South China Sea (SCS) is one of the largest marginal seas in the western Pacific. Its northern part has the features of a passive continental margin. The studies of deep crustal structure in this area are very important for understanding the tectonic nature, evolution history, basin formation of the northern margin, and the origin of the SCS. In the past decades, the deep seismic experiments of crustal studies in the northern SCS have gone through three stages, namely the sonobuoy, two-ship Expanding Spread Profile (ESP), and Ocean Bottom Hydrophone/Seismometer (OBH/OBS). Along the continental slope, the sonobuoy experiments provided useful information about the velocity structure of the upper crust, while the ESP data recorded for the first time the seismic signals from deep crustal structure and Moho interface. And the OBH/OBS profiles revealed the crustal structure in much greater detail. This paper first gives a brief historical review of these deep seismic experiments and studies, then a summary of the latest progress and important research results. The remaining problems and suggestions for further research work are presented as conclusive remarks.

  9. Drug silica nanocomposite: preparation, characterization and skin permeation studies.

    Science.gov (United States)

    Pilloni, Martina; Ennas, Guido; Casu, Mariano; Fadda, Anna Maria; Frongia, Francesca; Marongiu, Francesca; Sanna, Roberta; Scano, Alessandra; Valenti, Donatella; Sinico, Chiara

    2013-01-01

    The aim of this work was to evaluate silica nanocomposites as topical drug delivery systems for the model drug, caffeine. Preparation, characterization, and skin permeation properties of caffeine-silica nanocomposites are described. Caffeine was loaded into the nanocomposites by grinding the drug with mesoporous silica in a ball mill up to 10 h and the efficiency of the process was studied by XRPD. Formulations were characterized by several methods that include FTIR, XRPD, SEM and TEM. The successful loading of caffeine was demonstrated by XRPD and FTIR. Morphology was studied by SEM that showed particle size reduction while TEM demonstrated formation of both core-shell and multilayered caffeine-silica structures. Solid-state NMR spectra excluded chemical interactions between caffeine and silica matrix, thus confirming that no solid state reactions occurred during the grinding process. Influence of drug inclusion in silica nanocomposite on the in vitro caffeine diffusion into and through the skin was investigated in comparison with a caffeine gel formulation (reference), using newborn pig skin and vertical Franz diffusion cells. Results from the in vitro skin permeation experiments showed that inclusion into the nanocomposite reduced and delayed caffeine permeation from the silica nanocomposite in comparison with the reference, independently from the amount of the tested formulation. PMID:22324371

  10. A Study On Agroclimatic Characterization Of Albanian Territory

    Directory of Open Access Journals (Sweden)

    Albert Kopali

    2012-09-01

    Full Text Available The studies in agro-ecology, under the conditions of agricultural orientation of Albania make necessary the climate classification of agricultural areas, based on the suitability of agricultural plant groups, whose productivity level and sustainability depend on the performance and fluctuations of climatic elements. The introduction of new cultivation technologies of plants with low environmental impact requires the recognition of environmental features and in particular the climate one with the intention of satisfying the needs of each plant cultivated which is cultivated and spread in that area. To be more precise, the characterization and climatic zoning of the territory is considered to a valuable study in order to determine the most appropriate ecological zones in the country. For purposes of characterization of similar climate zones in the Albanian territory have been taken the historical series of climate data, which have been digitized and processed by applying the method "Cluster analysis" with the view to distinguishing their climate features, which will serve to distinguish the closely-related ecological areas and designing appropriate technologies for cultivation of plants based on such data.

  11. Prevalence and progression of combined pulmonary fibrosis and emphysema in asymptomatic smokers: A case-control study

    International Nuclear Information System (INIS)

    We aimed to estimate the prevalence of combined pulmonary fibrosis and emphysema (CPFE) and describe the follow-up CT results of CPFE in asymptomatic smokers. This study was retrospective, and approved by an institutional review board. CT images of 2,016 current or previous male smokers who underwent low-dose chest CT at our healthcare centre were reviewed. Quantitative CT analysis was used to assess the extent of emphysema, and two radiologists visually analyzed the extent of fibrosis. Changes in fibrosis (no change, improvement, or progression) were evaluated on follow-up CT imaging (n = 42). Kaplan-Meier survival analysis, multivariate logistic regression and its ROC curve were used for survival and progression analysis. The prevalence of CPFE among asymptomatic male smokers was 3.1 % (63/2,016). The median follow-up period was 50.4 months, and 72.7 % (16/22) of continued smoker had progressing fibrosis on follow-up CT. CPFE progressed more rapidly in continuous smokers than in former smokers (p = 0.002). The 3.5-year follow-up period after initial CPFE diagnosis maximized the sum of sensitivity and specificity of CPFE progression prediction in continuous smokers. The prevalence of CPFE turned out not to be inconsiderable in asymptomatic male smokers, but serial CT follow-up would be helpful in recognizing disease progression. (orig.)

  12. Prevalence and progression of combined pulmonary fibrosis and emphysema in asymptomatic smokers: A case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Chae, Kum Ju; Jin, Gong Yong; Han, Young Min; Kim, Yong Seek; Chon, Su Bin; Lee, Young Sun [Chonbuk National University Medical School and Hospital, Department of Radiology, Institute of Medical Science, Research Institute of Clinical Medicine, Jeonju, Jeonbuk (Korea, Republic of); Kwon, Keun Sang [Chonbuk National University Medical School, Department of Preventive Medicine, Research Institute of Clinical Medicine, Jeonju, Jeonbuk (Korea, Republic of); Choi, Hye Mi [Chonbuk National University, Department of Statistics and Institute of Applied Statistics, Jeonju, Jeonbuk (Korea, Republic of); Lynch, David [National Jewish Health, Department of Radiology, Denver, CO (United States)

    2015-08-15

    We aimed to estimate the prevalence of combined pulmonary fibrosis and emphysema (CPFE) and describe the follow-up CT results of CPFE in asymptomatic smokers. This study was retrospective, and approved by an institutional review board. CT images of 2,016 current or previous male smokers who underwent low-dose chest CT at our healthcare centre were reviewed. Quantitative CT analysis was used to assess the extent of emphysema, and two radiologists visually analyzed the extent of fibrosis. Changes in fibrosis (no change, improvement, or progression) were evaluated on follow-up CT imaging (n = 42). Kaplan-Meier survival analysis, multivariate logistic regression and its ROC curve were used for survival and progression analysis. The prevalence of CPFE among asymptomatic male smokers was 3.1 % (63/2,016). The median follow-up period was 50.4 months, and 72.7 % (16/22) of continued smoker had progressing fibrosis on follow-up CT. CPFE progressed more rapidly in continuous smokers than in former smokers (p = 0.002). The 3.5-year follow-up period after initial CPFE diagnosis maximized the sum of sensitivity and specificity of CPFE progression prediction in continuous smokers. The prevalence of CPFE turned out not to be inconsiderable in asymptomatic male smokers, but serial CT follow-up would be helpful in recognizing disease progression. (orig.)

  13. Neutron scattering studies in the actinide region. Progress report, August 1, 1991--July 31, 1994

    International Nuclear Information System (INIS)

    During the period August 1, 1991 to July 31, 1994 the authors report progress on the following: (a) prompt fission neutron energy spectra for 235U and 239Pu; (b) two-parameter measurement of nuclear lifetimes; (c) 'black' neutron detector; (d) data reduction techniques for neutron scattering experiments; (e) elastic and inelastic neutron scattering studies in 197Au; (f) elastic and inelastic neutron scattering studies in 239Pu; (g) neutron induced defects in silicon dioxide MOS structures; (h) response of a 235U fission chamber near reaction thresholds; (i) efficiency calibration of a liquid scintillation detector using the WNR facility at LAMPF; (j) prompt fission neutron energy spectrum measurements below the incident neutron energy; (k) multi-parameter data acquisition system; (l) accelerator improvements; (m) non-DOE supported research. Eight Ph.D. dissertations and two M.S. theses were completed during the report period. Publications consisted of 6 journal articles, 10 conference proceedings, and 19 abstracts of presentations at scientific meetings. One invited talk was given

  14. Progress in studies of the reciprocal interaction between sleep disorders and Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    LIU Zhen-yu

    2013-06-01

    Full Text Available Alzheimer's disease (AD is a common neurodegenerative disease in the elderly, and is the most common cause of dementia. Epidemiological studies have discovered that, 44% of patients with AD are associated with sleep disorders and (or circadian rhythm disorders. Now there are growing evidences indicating that interstitial fluid amyloid-β protein (A β levels exhibit circadian rhythm fluctuation, and sleep disorders will accelerate the process of Aβ deposition, which may act as a risk factor of AD, suggesting the possible reciprocal interaction between sleep disorders and AD. The mechanism is not yet completely clear. Sleep disorders may be related with the impairments of both sleep-wake regulating system, circadian rhythm regulating system and the change of zeitgeber in AD. Sleep disorders would affect neuronal activity, neurotransmitter secretion, and as a stressor affecting A β processing and metabolism, thus accelerate the pathological process of AD. This paper reviewed the progress in the studies of reciprocal interaction between sleep disorders and Alzheimer's disease and the possible mechanisms.

  15. Hydrocarbon studies in Puget Sound and off the Washington coast. Progress report, March 1977--February 1978

    International Nuclear Information System (INIS)

    This report summarizes progress in the first 2.5 yrs of our studies of the amounts, types, and probable origins of aliphatic, aromatic, S-, and N-containing hydrocarbons in sediments, organisms, and waters of Puget Sound and the Washington coast. We are trying to identify the relative importances of the various possible sources of these substances, the major pathways by which they are transferred through some parts of the marine food web, their rates of transfer, and their ultimate fates. We have found that changes in aliphatic and aromatic hydrocarbon compositions are evident in 210Pb dated sediment cores from central Puget Sound. These changes are due both to natural diagenetic processes and to low level inputs of fossil fuels from a variety of sources. We have found measurable amounts of both S- and N-containing compounds in these Puget Sound sediments. We believe the first results of our studies of the role of zooplankton fecal pellets in the cycling of trace chemicals in the sea have shown that fecal pellets are an important vertical transport agent for hydrocarbons in the sea. We now have defined the natural variations in 14C and 13C/12C isotope ratios of the inorganic carbon in Puget Sound seawater. Carbon isotope abundances for organisms and sediments are also reported for selected sites

  16. Characterization and isolation of a light driven sodium pump from membranes of Halobacterium halobium. Final technical progress report

    International Nuclear Information System (INIS)

    We investigated three aspects of the light driven sodium pump (halorhodopsin, which appear to be crucial to our understanding of the mechanisms employed by Halobacterium halobium and to further investigate this unique system of energy conservation. We characterized the molecular mechanisms of transmembrane sodium transport in vesicles from H. halobium with particular reference to the mechanism of couplins of light energy to net sodium translocation. We develop procedures and techniques for extracting the components of the light driven sodium pump from membranes and incorporating them into artificial membrane systems. We examine the mechanism of conversion of bacteriorhodopsin from an active to an inactive form in membrane vesicles and to relate this alternative state of this pigment to the presence of the light driven sodium pump

  17. Biochemical characterization of protein quality control mechanisms during disease progression in the C22 mouse model of CMT1A

    Directory of Open Access Journals (Sweden)

    Vinita G. Chittoor

    2013-12-01

    Full Text Available Charcot–Marie–Tooth disease type 1A (CMT1A is a hereditary demyelinating neuropathy linked with duplication of the peripheral myelin protein 22 (PMP22 gene. Transgenic C22 mice, a model of CMT1A, display many features of the human disease, including slowed nerve conduction velocity and demyelination of peripheral nerves. How overproduction of PMP22 leads to compromised myelin and axonal pathology is not fully understood, but likely involves subcellular alterations in protein homoeostatic mechanisms within affected Schwann cells. The subcellular response to abnormally localized PMP22 includes the recruitment of the ubiquitin–proteasome system (UPS, autophagosomes and heat-shock proteins (HSPs. Here we assessed biochemical markers of these protein homoeostatic pathways in nerves from PMP22-overexpressing neuropathic mice between the ages of 2 and 12 months to ascertain their potential contribution to disease progression. In nerves of 3-week-old mice, using endoglycosidases and Western blotting, we found altered processing of the exogenous human PMP22, an abnormality that becomes more prevalent with age. Along with the ongoing accrual of misfolded PMP22, the activity of the proteasome becomes compromised and proteins required for autophagy induction and lysosome biogenesis are up-regulated. Moreover, cytosolic chaperones are consistently elevated in nerves from neuropathic mice, with the most prominent change in HSP70. The gradual alterations in protein homoeostatic response are accompanied by Schwann cell de-differentiation and macrophage infiltration. Together, these results show that while subcellular protein quality control mechanisms respond appropriately to the presence of the overproduced PMP22, with aging they are unable to prevent the accrual of misfolded proteins.

  18. Characterization Study of Accelerator for Application in Biotechnology

    International Nuclear Information System (INIS)

    The characterization of accelerator for application in biotechnology was studied. Accelerator is a machine to produce ion beam particles. Accelerator can be used for biotechnology experiments. Ion beam particles irradiation on the biological material will produced variabilities of genetics and induced mutations. In general, new varieties were found by hybridization method or mutation breeding method by gamma rays irradiation. Ion beam particles can be used for biological material irradiation to find variabilities of genetics and induced mutations. The high percentage of mutation rate and LET value by ion beam particles irradiation was found higher than by gamma rays irradiation. Ion beam particle irradiation can also be controlled and foewed to target in biological material. The characterization of accelerator needed for biotechnology experiments are types of accelerator (Tandem Van de Graff, AVF Cyclotron, Synchrotron, Rilac), types of ion particles (C, He, electron, Ar, Ne, Ni, Al, Xe and Au), range of energy (5 - 2.090 MeV), range of dose irradiation (10 - 250 Gy), range of ion current (0.02 - 20 nA), range of ion beam particles diameter (10 - 100 μm), range of LET value (300 - 1.800 keV/μm ) and irradiation time (5 - 30 seconds/samples). (author)

  19. External irradiation facilities open for biological studies - progress in july 2005

    International Nuclear Information System (INIS)

    The Life Science Division of the Atomic Energy Commission is making an inventory of the various radiation sources accessible for investigation on the biological effects of ionizing radiation. In this field, a wide range of studies is being carried out at the Life Science Division, attempting to characterize the kind of lesions with their early biological consequences (on the various cell compartments) and their late biological consequences (deterministic or stochastic effects), in relation to the radiation type and dose, especially at low doses. Several experimental models are available: plants, bacteria, eukaryotic cells from yeast up to mammalian cells and in vivo studies, mostly on rodents, in order to characterize the somatic late effects and the hereditary effects. Due to the significant cost of these facilities, also to their specific properties (nature of the radiation, dose and dose rate, possible accuracy of the irradiation at the molecular level), the closeness is no longer the only criteria for biologists to make a choice. The current evolution is to set up irradiation infrastructures combining ionizing radiation sources themselves and specific tools dedicated to biological studies: cell or molecular biology laboratories, animal facilities. The purpose, in this new frame, is to provide biologists with the most suitable facilities, and, if possible, to change these facilities according to requirements in radiobiology. In this report, the basics of interactions of ionizing radiation with biological tissues are briefly introduced, followed by a presentation of some of the facilities available for radiobiological studies especially at CEA. This panorama is not a comprehensive one, new data will be included as they advance, whether reporting existing facilities or if a new one is developed. (authors)

  20. Electron microscope studies. Progress report, 1 July 1990--1 June 1991

    Energy Technology Data Exchange (ETDEWEB)

    Crewe, A.V.; Kapp, O.H.

    1991-06-01

    This year our laboratory has continued to make progress in the design of electron-optical systems, in the study of structure-function relationships of large multi-subunit proteins, in the development of new image processing software and in achieving a workable sub-angstrom STEM. We present an algebraic approach to the symmetrical Einzel (unipotential) lens wherein we simplify the analysis by specifying a field shape that meets some preferred set of boundary or other conditions and then calculate the fields. In a second study we generalize this approach to study of three element electrostatic lenses of which the symmetrical Einzel lens is a particular form. The purpose is to develop a method for assisting in the design of a lens for a particular purpose. In our biological work we study a stable and functional dodecameric complex of globin chains from the hemoglobin of Lumbricus terrestris. This is a complex lacking the ``linker`` subunit first imaged in this lab and required for maintenance of the native structure. In addition, we do a complete work-up on the hemoglobin of the marine polychaete Eudistylia vancouverii demonstrating the presence of a hierarchy of globin complexes. We demonstrate stable field-emission in the sub-angstrom STEM and the preliminary alignment of the beam. We continue our exploration of a algorithms for alignment of sequences of protein and DNA. Our computer facilities now include four second generation RISC workstations and we continue to take increasing advantage of the floating-point and graphical performance of these devices.

  1. Undergraduate Use of Library Databases Decreases as Level of Study Progresses

    Directory of Open Access Journals (Sweden)

    Kimberly Miller

    2014-09-01

    Full Text Available A Review of: Mbabu, L.G., Bertram, A. B., & Varnum, K. (2013. Patterns of undergraduates’ use of scholarly databases in a large research university. Journal of Academic Librarianship, 39(2, 189-193. http://dx.doi.org/10.10.1016/j.acalib.2012.10.004 Abstract Objective – To investigate undergraduate students’ patterns of electronic database use to discover whether database use increases as undergraduate students progress into later stages of study with increasingly sophisticated information needs and demands. Design – User database authentication log analysis. Setting – A large research university in the Midwestern United States of America. Subjects – A total of 26,208 undergraduate students enrolled during the Fall 2009 academic semester. Methods – The researchers obtained logs of user-authenticated activity from the university’s databases. Logged data for each user included: the user’s action and details of that action (including database searches, the time of action, the user’s relationship to the university, the individual school in which the user was enrolled, and the user’s class standing. The data were analyzed to determine which proportion of undergraduate students accessed the library’s electronic databases. The study reports that the logged data accounted for 61% of all database activity, and the authors suggest the other 39% of use is likely from “non-undergraduate members of the research community within the [university’s] campus IP range” (192. Main Results – The study found that 10,897 (42% of the subject population of undergraduate students accessed the library’s electronic databases. The study also compared database access by class standing, and found that freshman undergraduates had the highest proportion of database use, with 56% of enrolled freshman accessing the library’s databases. Sophomores had the second highest proportion of students accessing the databases at 40%; juniors and seniors

  2. Breaking Away from Progressive History: The Past and Politics in American Studies

    OpenAIRE

    Helo, Ari

    2014-01-01

    This article suggests that, contrary to a widely shared view among American scholars, a progressive view of history is neither essential nor helpful to historical research in American studies—or in any other academic field.

  3. A population-based study of stimulant drug treatment of ADHD and academic progress in children

    DEFF Research Database (Denmark)

    Zoëga, Helga; Rothman, Kenneth J; Huybrechts, Krista F;

    2012-01-01

    We evaluated the hypothesis that later start of stimulant treatment of attention-deficit/hyperactivity disorder adversely affects academic progress in mathematics and language arts among 9- to 12-year-old children....

  4. Randomized controlled trial to evaluate the effects of progressive resistance training compared to progressive muscle relaxation in breast cancer patients undergoing adjuvant radiotherapy: the BEST study

    International Nuclear Information System (INIS)

    Cancer-related fatigue (CRF) is one of the most common and distressing side effects of cancer and its treatment. During and after radiotherapy breast cancer patients often suffer from CRF which frequently impairs quality of life (QoL). Despite the high prevalence of CRF in breast cancer patients and the severe impact on the physical and emotional well-being, effective treatment methods are scarce. Physical activity for breast cancer patients has been reported to decrease fatigue, to improve emotional well-being and to increase physical strength. The pathophysiological and molecular mechanisms of CRF and the molecular-biologic changes induced by exercise, however, are poorly understood. In the BEST trial we aim to assess the effects of resistance training on fatigue, QoL and physical fitness as well as on molecular, immunological and inflammatory changes in breast cancer patients during adjuvant radiotherapy. The BEST study is a prospective randomized, controlled intervention trial investigating the effects of a 12-week supervised progressive resistance training compared to a 12-week supervised muscle relaxation training in 160 patients with breast cancer undergoing adjuvant radiotherapy. To determine the effect of exercise itself beyond potential psychosocial group effects, patients in the control group perform a group-based progressive muscle relaxation training. Main inclusion criterion is histologically confirmed breast cancer stage I-III after lumpectomy or mastectomy with indication for adjuvant radiotherapy. Main exclusion criteria are acute infectious diseases, severe neurological, musculosceletal or cardiorespiratory disorders. The primary endpoint is cancer-related fatigue; secondary endpoints include immunological and inflammatory parameters analyzed in peripheral blood, saliva and urine. In addition, QoL, depression, physical performance and cognitive capacity will be assessed. The BEST study is the first randomized controlled trial comparing progressive

  5. Progression of kidney disease in type 2 diabetes – beyond blood pressure control: an observational study

    OpenAIRE

    Chatha Maninder P; Daoud Tarek M; Kramer Holly J; Leehey David J; Isreb Majd A

    2005-01-01

    Abstract Background The risk factors for progression of chronic kidney disease (CKD) in type 2 diabetes mellitus (DM) have not been fully elucidated. Although uncontrolled blood pressure (BP) is known to be deleterious, other factors may become more important once BP is treated. Methods All patients seen in the outpatient clinics of our hospital between January 1993 and September 2002 with type 2 DM and clinical evidence of CKD were evaluated. Progression of kidney disease was evaluated by ra...

  6. Eradication of Helicobacter pylori Is Associated with the Progression of Dementia: A Population-Based Study

    OpenAIRE

    Yang-Pei Chang; Guei-Fen Chiu; Fu-Chen Kuo; Chiou-Lian Lai; Yuan-Han Yang; Huang-Ming Hu; Pi-Yu Chang; Chiao-Yun Chen; Deng-Chyang Wu; Fang-Jung Yu

    2013-01-01

    Objective. To evaluate the effect of eradication of Helicobacter pylori (H. pylori) on the progression of dementia in Alzheimer’s disease (AD) patients with peptic ulcer. Methods. Participants with the diagnosis of AD and peptic ulcer were recruited between 2001 and 2008. We examined the association between eradication of H. pylori and the progression of AD using the multiple regression models. Medication shift from Donepezil, Rivastgmine, and Galantamine to Mematine is defined as progres...

  7. IVUS-Based FSI Models for Human Coronary Plaque Progression Study: Components, Correlation and Predictive Analysis

    OpenAIRE

    WANG, LIANG; Wu, Zheyang; Yang, Chun; Zheng, Jie; Bach, Richard; Muccigrosso, David; Billiar, Kristen; Maehara, Akiko; Mintz, Gary S; Tang, Dalin

    2014-01-01

    Atherosclerotic plaque progression is believed to be associated with mechanical stress conditions. Patient follow-up in vivo intravascular ultrasound coronary plaque data were acquired to construct fluid-structure interaction (FSI) models with cyclic bending to obtain flow wall shear stress (WSS), plaque wall stress (PWS) and strain (PWSn) data and investigate correlations between plaque progression measured by wall thickness increase (WTI), cap thickness increase (CTI), lipid depth increase ...

  8. Study and microscopic characterization of the cadmium telluride deep levels

    International Nuclear Information System (INIS)

    The spectroscopic methods PICTS, QTS and CTS were developed and perfected to investigate deep level analysis of high resistivity CdTe crystals which were either undoped, or doped with chlorine and copper. Crystals which were grown in space were also investigated. The main characterization of defect levels was determined and different correlations were established between the material's resistivity, chemical residues, dopant concentration and the nuclear radiation detector parameters. Using PICTS and CTS techniques, the generation of defects, under strong gamma-ray irradiation and particle bombardment was also studied. The influence of hydrogen on the main electrical characteristics of CdTe, in particular its ability to passivate the electrical activity of many deep defect and impurity states have been demonstrated. The compensation effects of Cl, Cu and H+ are interpreted using the qualitative models based on different possibilities of pairing or triplet formation between the ions of these dopants and those of defects

  9. A Study on the Characterization of Jude the Obscure

    Institute of Scientific and Technical Information of China (English)

    苏焕

    2007-01-01

    This paper is a brief study on the characterization of Jude the Obscure,and will be focus on the chief character Jude Fawley.This novel,first published in 1895,wasThomas Hardy's last and best literary success.There are six main characters in this novel:Jude Fawley,Susanna Bridehead,Arabella Donn,Richard Phillotson,Aunt Drusilla,Little Father Time(Little Jude).This analysis of the distinct depictions of the typical characters will be helpful to the understanding of the gap between the ideal life a man wishes to lead and the squalid existence he is fated to live in such social environment as Jude is confronted with.

  10. Carbohydrate-derived hydrothermal carbons: a thorough characterization study.

    Science.gov (United States)

    Yu, Linghui; Falco, Camillo; Weber, Jens; White, Robin J; Howe, Jane Y; Titirici, Maria-Magdalena

    2012-08-21

    Hydrothermal carbonization (HTC) is an aqueous-phase route to produce carbon materials using biomass or biomass-derived precursors. In this paper, a comprehensive physicochemical and textural characterization of HTC materials obtained using four different precursors, namely, xylose, glucose, sucrose, and starch, is presented. The development of porosity in the prepared HTC materials as a function of thermal treatment (under an inert atmosphere) was specifically monitored using N(2) and CO(2) sorption analysis. The events taking place during the thermal treatment process were studied by a combined thermogravimetric/infrared (TGA-IR) measurement. Interestingly, these inexpensive biomass-derived carbon materials show good selectivity for CO(2) adsorption over N(2) (CO(2)/N(2) selectivity of 20 at 273 K, 1 bar and 1:1 gas composition). Furthermore, the elemental composition, morphologies, degree of structural order, surface charge, and functional groups are also investigated. PMID:22853745

  11. Large cross-sectional study of presbycusis reveals rapid progressive decline in auditory temporal acuity.

    Science.gov (United States)

    Ozmeral, Erol J; Eddins, Ann C; Frisina, D Robert; Eddins, David A

    2016-07-01

    The auditory system relies on extraordinarily precise timing cues for the accurate perception of speech, music, and object identification. Epidemiological research has documented the age-related progressive decline in hearing sensitivity that is known to be a major health concern for the elderly. Although smaller investigations indicate that auditory temporal processing also declines with age, such measures have not been included in larger studies. Temporal gap detection thresholds (TGDTs; an index of auditory temporal resolution) measured in 1071 listeners (aged 18-98 years) were shown to decline at a minimum rate of 1.05 ms (15%) per decade. Age was a significant predictor of TGDT when controlling for audibility (partial correlation) and when restricting analyses to persons with normal-hearing sensitivity (n = 434). The TGDTs were significantly better for males (3.5 ms; 51%) than females when averaged across the life span. These results highlight the need for indices of temporal processing in diagnostics, as treatment targets, and as factors in models of aging. PMID:27255816

  12. Establishment of an Institute for Fusion Studies. Technical progress report, November 1, 1991--October 31, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Hazeltine, R.D.

    1992-07-01

    The Institute for Fusion Studies is a national center for theoretical fusion plasma physics research. Its purposes are: (1) to conduct research on theoretical questions concerning the achievement of controlled fusion energy by means of magnetic confinement--including both fundamental problems of long-range significance, as well as shorter-term issues; (2) to serve as a center for information exchange, nationally and internationally, by hosting exchange visits, conferences, and workshops; (3) and to train students and postdoctoral research personnel for the fusion energy program and plasma physics research areas. The theoretical research results that are obtained by the Institute contribute mainly to the progress of national and international efforts in nuclear fusion research, whose goal is the development of fusion power.as a basic energy source. In addition to its primary focus on fusion physics, the Institute is also involved with research in related fields, such as advanced computing techniques, nonlinear dynamics, plasma astrophysics, and accelerator physics. The work of EFS scientists continued to receive national and international recognition. Numerous invited papers were given during the past year at workshops, conferences, and scientific meetings. Last year IFS scientists published 95 scientific articles in technical journals and monographs.

  13. Early career choices and successful career progression in surgery in the UK: prospective cohort studies

    Directory of Open Access Journals (Sweden)

    Richards Jennifer MJ

    2010-11-01

    Full Text Available Abstract Background Changes to the structure of medical training worldwide require doctors to decide on their career specialty at an increasingly early stage after graduation. We studied trends in career choices for surgery, and the eventual career destinations, of UK graduates who declared an early preference for surgery. Methods Postal questionnaires were sent, at regular time intervals after qualification, to all medical qualifiers from all UK medical schools in selected qualification years between 1974 and 2005. They were sent in the first year after qualification, at year three and five years after qualification, and at longer time intervals thereafter. Results Responses were received from 27 749 of 38 280 doctors (73% at year one, 23 468 of 33151 (71% at year three, and 17 689 of 24 870 (71% at year five. Early career preferences showed that surgery has become more popular over the past two decades. Looking forward from early career choice, 60% of respondents (64% of men, 48% of women with a first preference for a surgical specialty at year one eventually worked in surgery (p Conclusions Surgery is a popular specialty choice in the UK. The great majority of doctors who progressed in a surgical career made an early and definitive decision to do so.

  14. ITER ECE diagnostic: design progress of IN-DA and its role for physics study

    International Nuclear Information System (INIS)

    The ECE Diagnostic system in ITER will be used for measuring the electron temperature profile evolution, electron temperature fluctuations, the runaway electron spectrum, and the radiated power in the electron cyclotron frequency range (70-1000 GHz), These measurements will be used for advanced real time plasma control (eg. steering the electron cyclotron heating beams), and physics studies. The polarization splitter unit consists of a Gaussian beam telescope with wire grid polarizer selector and the transmission system that includes straight waveguide sections, miter bends, a vacuum window and some quasi-optical components. Waveguide sections are joined together to transmit the emission to the Diagnostics Hall nearly 40 meters away from the port plug optics. The required transmission loss ≤15 dB (up to 400GHz) and ≤ 22 dB (for 400 to 1000 GHz) is a significant design challenge. The high throughput Michelson interferometer with frequency resolution ≤ 3.75 GHz and scanning repetition rate ≥ 50 Hz in a low vacuum is yet another design challenge. The design also needs to conform to the ITER Organization's strict requirements for reliability, availability, maintainability and inspectability. Progress in the design and development of various subsystems and components considering various engineering challenges and solutions will be discussed in this paper. Enhancing the understanding of plasma physics using various measurements of ECE diagnostics will also be highlighted

  15. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy.

    Science.gov (United States)

    Kouri, Naomi; Ross, Owen A; Dombroski, Beth; Younkin, Curtis S; Serie, Daniel J; Soto-Ortolaza, Alexandra; Baker, Matthew; Finch, Ni Cole A; Yoon, Hyejin; Kim, Jungsu; Fujioka, Shinsuke; McLean, Catriona A; Ghetti, Bernardino; Spina, Salvatore; Cantwell, Laura B; Farlow, Martin R; Grafman, Jordan; Huey, Edward D; Ryung Han, Mi; Beecher, Sherry; Geller, Evan T; Kretzschmar, Hans A; Roeber, Sigrun; Gearing, Marla; Juncos, Jorge L; Vonsattel, Jean Paul G; Van Deerlin, Vivianna M; Grossman, Murray; Hurtig, Howard I; Gross, Rachel G; Arnold, Steven E; Trojanowski, John Q; Lee, Virginia M; Wenning, Gregor K; White, Charles L; Höglinger, Günter U; Müller, Ulrich; Devlin, Bernie; Golbe, Lawrence I; Crook, Julia; Parisi, Joseph E; Boeve, Bradley F; Josephs, Keith A; Wszolek, Zbigniew K; Uitti, Ryan J; Graff-Radford, Neill R; Litvan, Irene; Younkin, Steven G; Wang, Li-San; Ertekin-Taner, Nilüfer; Rademakers, Rosa; Hakonarsen, Hakon; Schellenberg, Gerard D; Dickson, Dennis W

    2015-01-01

    Corticobasal degeneration (CBD) is a neurodegenerative disorder affecting movement and cognition, definitively diagnosed only at autopsy. Here, we conduct a genome-wide association study (GWAS) in CBD cases (n=152) and 3,311 controls, and 67 CBD cases and 439 controls in a replication stage. Associations with meta-analysis were 17q21 at MAPT (P=1.42 × 10(-12)), 8p12 at lnc-KIF13B-1, a long non-coding RNA (rs643472; P=3.41 × 10(-8)), and 2p22 at SOS1 (rs963731; P=1.76 × 10(-7)). Testing for association of CBD with top progressive supranuclear palsy (PSP) GWAS single-nucleotide polymorphisms (SNPs) identified associations at MOBP (3p22; rs1768208; P=2.07 × 10(-7)) and MAPT H1c (17q21; rs242557; P=7.91 × 10(-6)). We previously reported SNP/transcript level associations with rs8070723/MAPT, rs242557/MAPT, and rs1768208/MOBP and herein identified association with rs963731/SOS1. We identify new CBD susceptibility loci and show that CBD and PSP share a genetic risk factor other than MAPT at 3p22 MOBP (myelin-associated oligodendrocyte basic protein). PMID:26077951

  16. Rural Development in Bangladesh since Independence: A Study on Progress and Performance

    Directory of Open Access Journals (Sweden)

    Mohammad Ismail Hossain

    2012-09-01

    Full Text Available Rural development has been the core focus of the Bangladesh economic policies since her independence. The rural sector is pivotal to the country‟s economic, social and political development. This paper examines the Bangladesh rural development policies, strategies and programs since Independence in 1971. Secondary data were used and collected from various sources especially from BBS and HIES. Data were analyzed using descriptive statistical tools such as mean and percentage to reach the objectives. Results of this study show that the share of agricultural sector in the country‟s GDP has declined which is an indicator of a country‟s progress from an agriculture-based to an export-oriented economy. The success of the agricultural and rural programs in Bangladesh is reflected in the reduction in the poverty incidence in the rural sector from almost 54 percent in the 1983-84 to about 35 percent in 2009-10. Development efforts of Bangladesh are governed by the twin objectives of achieving growth with equity and reducing poverty. The government policy has to some extent achieved the intended results but poverty and inequality are still significant and apparent. Hence, rural development continues to be an important agenda to the country‟s development effort.

  17. Biochemical and neuroimaging studies in subjective cognitive decline: progress and perspectives.

    Science.gov (United States)

    Sun, Yu; Yang, Fu-Chi; Lin, Ching-Po; Han, Ying

    2015-10-01

    Neurodegeneration due to Alzheimer's disease (AD) can progress over decades before dementia becomes apparent. Indeed, patients with mild cognitive impairment (MCI) already demonstrate significant lesion loads. In most cases, MCI is preceded by subjective cognitive decline (SCD), which is applied to individuals who have self-reported memory-related complaints and has been associated with a higher risk of future cognitive decline and conversion to dementia. Based on the schema of a well-received model of biomarker dynamics in AD pathogenesis, it has been postulated that SCD symptoms may result from compensatory changes in response to β-amyloid accumulation and neurodegeneration. Although SCD is considered a prodromal stage of MCI, it is also a common manifestation in old age, independent of AD, and the predictive value of SCD for AD pathology remains controversial. Here, we provide a review focused on the contributions of cross-sectional and longitudinal analogical studies of biomarkers and neuroimaging evidence in disentangling under what conditions SCD may be attributable to AD pathology. In conclusion, there is promising evidence indicating that clinicians should be able to differentiate pre-AD SCD based on the presence of pathophysiological biomarkers in cerebrospinal fluid (CSF) and neuroimaging. However, this neuroimaging approach is still at an immature stage without an established rubric of standards. A substantial amount of work remains in terms of replicating recent findings and validating the clinical utility of identifying SCD. PMID:25864576

  18. Chronic progressive external ophthalmoplegia: I. A quantitative histochemical study of skeletal muscles

    Directory of Open Access Journals (Sweden)

    Elza Dias-Tosta

    1988-06-01

    Full Text Available This study quantitates the major morphological and cytochemical changes in limb muscle biopsies from 37 patients with the, syndrome of chronic progressive external ophthalmoplegia (CPEO. The aim was to assess the value of limb muscle biopsy in the diagnosis of this syndrome; to define the myopathological changes and to determine whether there were any specific clinico-pathological correlations. Patients were divided into three clinical groups - 11 patients with CPEO with facial and/or limb muscle weakness; 10 with CPEO with facial and/or limb muscle weakness and a positive family history; 16 with CPEO with one or more of the following: pigmentary retinopathy, cerebellar ataxia, pyramidal signs and peripheral neuropathy. The following parameters were measured: the proportions of histochemical fibre types, the muscle fibre areas and the percentage of muscle fibres showing increased oxidative enzyme activity. Pooled results for each of the clinical categories were compared. Statistical analysis of fibre areas and the percentage of fibres with increased oxidative enzyme activity, showed that group 2 differed from the others (p < 0.05. Patients in group 2 showed the highest incidence of type 1 fibre hypertrophy, type 2A atrophy and the lowest incidence of fibres with increased oxidative activity. Fibre type disproportions occurred in all three groups but the differences were not significant.

  19. Chronic progressive external ophthalmoplegia: II. A qualitative and quantitative electronmicroscopy study of skeletal muscles

    Directory of Open Access Journals (Sweden)

    Elza Dias-Tosta

    1988-06-01

    Full Text Available This study quantifies the maior electron microscopic changes in limb muscle biopsies from 31 out of 34 patients with the syndrome of chronic progressive external ophthalmoplegia. Patients were divided into three clinical groups - A 10 sporadic cases with muscle weakness only; B 9 familial cases with muscle weakness only; C 15 cases with muscle weakness and one or more of the following features: pigmentary retinopathy, cerebellar ataxia, pyramidal signs and peripheral neuropathy. Electron microscopic mitochondrial abnormalities were found in all groups (8 patients from group A, 3 from group B, 14 from group C. Quantitative measurements of certain muscle fibre constituents, using a point-counting technique, revealed decreased myofibril volume-fractions and increased volume-fractions of mitochondria, glycogen and lipid in some biopsies from each group. Mitochondrial volume-fractions correlated positively with lipid content, the proportion of type 1 fibres, and the percentage of fibres with increased oxidative enzyme activity. The three groups defined clinically showed no significant differences in terms of the relative proportions of these measured constituents.

  20. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy

    Science.gov (United States)

    Kouri, Naomi; Ross, Owen A.; Dombroski, Beth; Younkin, Curtis S.; Serie, Daniel J.; Soto-Ortolaza, Alexandra; Baker, Matthew; Finch, Ni Cole A.; Yoon, Hyejin; Kim, Jungsu; Fujioka, Shinsuke; McLean, Catriona A.; Ghetti, Bernardino; Spina, Salvatore; Cantwell, Laura B.; Farlow, Martin R.; Grafman, Jordan; Huey, Edward D.; Ryung Han, Mi; Beecher, Sherry; Geller, Evan T.; Kretzschmar, Hans A.; Roeber, Sigrun; Gearing, Marla; Juncos, Jorge L.; Vonsattel, Jean Paul G.; Van Deerlin, Vivianna M.; Grossman, Murray; Hurtig, Howard I.; Gross, Rachel G.; Arnold, Steven E.; Trojanowski, John Q.; Lee, Virginia M.; Wenning, Gregor K.; White, Charles L.; Höglinger, Günter U.; Müller, Ulrich; Devlin, Bernie; Golbe, Lawrence I.; Crook, Julia; Parisi, Joseph E.; Boeve, Bradley F.; Josephs, Keith A.; Wszolek, Zbigniew K.; Uitti, Ryan J.; Graff-Radford, Neill R.; Litvan, Irene; Younkin, Steven G.; Wang, Li-San; Ertekin-Taner, Nilüfer; Rademakers, Rosa; Hakonarsen, Hakon; Schellenberg, Gerard D.; Dickson, Dennis W.

    2015-01-01

    Corticobasal degeneration (CBD) is a neurodegenerative disorder affecting movement and cognition, definitively diagnosed only at autopsy. Here, we conduct a genome-wide association study (GWAS) in CBD cases (n=152) and 3,311 controls, and 67 CBD cases and 439 controls in a replication stage. Associations with meta-analysis were 17q21 at MAPT (P=1.42 × 10−12), 8p12 at lnc-KIF13B-1, a long non-coding RNA (rs643472; P=3.41 × 10−8), and 2p22 at SOS1 (rs963731; P=1.76 × 10−7). Testing for association of CBD with top progressive supranuclear palsy (PSP) GWAS single-nucleotide polymorphisms (SNPs) identified associations at MOBP (3p22; rs1768208; P=2.07 × 10−7) and MAPT H1c (17q21; rs242557; P=7.91 × 10−6). We previously reported SNP/transcript level associations with rs8070723/MAPT, rs242557/MAPT, and rs1768208/MOBP and herein identified association with rs963731/SOS1. We identify new CBD susceptibility loci and show that CBD and PSP share a genetic risk factor other than MAPT at 3p22 MOBP (myelin-associated oligodendrocyte basic protein). PMID:26077951

  1. Nuclear structure and reaction studies at medium energies: Progress report, April 1988-March 1989

    International Nuclear Information System (INIS)

    This document constitutes the (1988--1989) progress report for the ongoing medium energy nuclear physics research programs supported by The US Department of Energy through special research grant DE-FG05-88ER40444. A major part of the work has been associated with research done at the Los Alamos Clinton P. Anderson Meson Physics Facility (LAMPF) using the High Resolution Spectrometer (HRS), the External Proton Beam (EPB), and the new Neutron Time of Flight Facility (NTOF). Other research has been done at the Fermi National Accelerator Laboratory (FNAL). The research effort focuses on: providing proton + nucleus data which test nonrelativistic and relativistic models of the medium energy proton + nucleus interaction, providing (p,p') and (p,n) data which are to be analyzed to provide new nuclear structure information (both ground state and excited state), providing nucleon + nucleon data to aid in the systematic study of the fundamental nucleon-nucleon interaction, developing and improving the proton + nucleus theoretical models themselves, and initiating new experimental programs whose goals are to search for new phenomena in nuclear physics

  2. The Fourier-Kelvin Stellar Interferometer (FKSI): Infrared Detection and Characterization of Exozodiacal Dust to Super-Earths, A Progress Report

    Science.gov (United States)

    Danchi, W.

    2010-01-01

    The Fourier-Kelvin Stellar Interferometer (FKSI) is a structurally connected infrared space interferometer with 0.5 m diameter telescopes on a 12.5 m baseline, and is passively cooled to approx.60K. The FKSI operates in the thermal infrared from 3-8 microns in a nulling (or starlight suppressing) mode for the detection and characterization of exoplanets, debris disks, extrasolar zodiacal dust levels. The FKSI will have the highest angular resolution of any infrared space instrument ever made with its nominal resolution of 40 mas at a 5 micron center wavelength. This resolution exceeds that of Spitzer by a factor of 38 and JWST by a factor of 5. The FKSI mission is conceived as a "probe class" or "mid-sized" strategic mission that utilizes technology advances from flagship projects like JWST, SIM, Spitzer, and the technology programs of TPF-I/Darwin. During the past year we began investigating an enhanced version of FKSI with 1-2 m diameter telescopes, passively cooled to 40K, on a 20-m baseline, with a sunshade giving a +/- 45 degree Field-of-Regard. This enhanced design is capable of detecting and characterizing the atmospheres of many 2 Earth-radius super-Earths and a few Earth-twins. We will report progress on the design of the enhanced mission concept and current status of the technologies needed for this mission.

  3. Progress in nonmagnetic impurity doping studies on Fe-based superconductors

    Science.gov (United States)

    Li, Jun; Guo, Yan-Feng; Yang, Zhao-Rong; Yamaura, Kazunari; Takayama-Muromachi, Eiji; Wang, Hua-Bing; Wu, Pei-Heng

    2016-05-01

    We review the progress of nonmagnetic impurity doping studies on Fe-based superconductors. On the theoretical side, two highly promising candidates for the pairing symmetry order parameter, i.e. the multi-gap s ++ and s ± wave models, have been proposed but continuously debated. The debate arises because of the complex gap structure and exceptional magnetic and metallic behaviors of Fe-based superconductors, which may vary the influence of nonmagnetic defects in the chemical potential, impurity disorder, inter- and intra-band scattering strength, and electron localization. This creates difficulties in directly obtaining the most important information for understanding the symmetry order parameter. Experimentally, nonmagnetic impurity substitution studies have been widely carried out, which have provided very useful insights. We review herein the various nonmagnetic impurity doping experiments, including the controlled defects within the superconducting Fe2 X 2 planes through sample quality improvement, single impurity effects on the electronic state and local moment, the magnetic response of the Fe2 X 2 planes both on the macroscopic scale as the antiferromagnetic state and the local scale of moment, as well as the significant effect of modifying the transport properties. The experiments enable us to qualitatively analyze the nonmagnetic impurity effects on the superconducting state for many Fe-based superconductors. We also propose herein some strategies for nonmagnetic impurity doping study. As an important model for explaining the nonmagnetic impurity doping effects, the pair-breaking model is compared with various theoretical approaches via analysis of the pair-breaking rates of various Fe-superconductors.

  4. Coal liquefaction process solvent characterization and evaluation: Technical progress report, July 1, 1986 through September 30, 1986

    Energy Technology Data Exchange (ETDEWEB)

    Robbins, G.A.; Winschel, R.A.; Burke, F.P.

    1987-03-01

    Conoco Coal Research Division is characterizing samples of direct coal liquefaction process oils based on a variety of analytical techniques to provide a detailed description of the chemical composition of the oils, to more fully understand the interrelationship of process oil composition and process operations, to aid in plant operation, and to lead to process improvements. The approach taken is to obtain analyses of a large number of well-defined process oils taken during periods of known operating conditions and known process performance. Close cooperation is maintained with the process developers and with DOE in order to maximize the benefits of the work. Analytical methods used are based on their ability to provide quantitatively valid measures of process oil composition. Particular use is made of methods which provide chemical/molecular information of proven relevance to process performance. In addition, all samples are treated using conventional methods of analysis and preparation so that unit performance parameters, such as conversions and yields, can be independently determined to assure sample validity and correlation of analytical results among various plant operations. 10 refs., 3 figs., 20 tabs.

  5. Systematic analytical characterization of new psychoactive substances: A case study.

    Science.gov (United States)

    Lobo Vicente, Joana; Chassaigne, Hubert; Holland, Margaret V; Reniero, Fabiano; Kolář, Kamil; Tirendi, Salvatore; Vandecasteele, Ine; Vinckier, Inge; Guillou, Claude

    2016-08-01

    New psychoactive substances (NPS) are synthesized compounds that are not usually covered by European and/or international laws. With a slight alteration in the chemical structure of existing illegal substances registered in the European Union (EU), these NPS circumvent existing controls and are thus referred to as "legal highs". They are becoming increasingly available and can easily be purchased through both the internet and other means (smart shops). Thus, it is essential that the identification of NPS keeps up with this rapidly evolving market. In this case study, the Belgian Customs authorities apprehended a parcel, originating from China, containing two samples, declared as being "white pigments". For routine identification, the Belgian Customs Laboratory first analysed both samples by gas-chromatography mass-spectrometry and Fourier-Transform Infrared spectroscopy. The information obtained by these techniques is essential and can give an indication of the chemical structure of an unknown substance but not the complete identification of its structure. To bridge this gap, scientific and technical support is ensured by the Joint Research Centre (JRC) to the European Commission Directorate General for Taxation and Customs Unions (DG TAXUD) and the Customs Laboratory European Network (CLEN) through an Administrative Arrangement for fast recognition of NPS and identification of unknown chemicals. The samples were sent to the JRC for a complete characterization using advanced techniques and chemoinformatic tools. The aim of this study was also to encourage the development of a science-based policy driven approach on NPS. These samples were fully characterized and identified as 5F-AMB and PX-3 using (1)H and (13)C nuclear magnetic resonance (NMR), high-resolution tandem mass-spectrometry (HR-MS/MS) and Raman spectroscopy. A chemoinformatic platform was used to manage, unify analytical data from multiple techniques and instruments, and combine it with chemical and

  6. Risk Factors Associated with the Incidence and Progression of Mitral Annulus Calcification: The Multi-Ethnic Study of Atherosclerosis

    Science.gov (United States)

    Elmariah, Sammy; Budoff, Matthew J.; Delaney, Joseph A. C.; Hamirani, Yasmin; Eng, John; Fuster, Valentin; Kronmal, Richard A.; Halperin, Jonathan L.; O’Brien, Kevin D.

    2013-01-01

    Background Significant cardiovascular morbidity has been associated with mitral annulus calcification (MAC), but limited data exist regarding its progression. The purpose of this study was to examine the natural history of and risk factors for MAC progression. Methods The Multi-Ethnic Study of Atherosclerosis (MESA) is a longitudinal cohort study of participants aged 45–84 years without clinical cardiovascular disease who underwent serial cardiac computed tomography studies with quantification of MAC. Regression models were used to identify risk factors associated with MAC incidence and progression. Results Prevalent MAC was observed in 534 of 5,895 (9%) participants. Over a median 2.3 years, 280 (5%) developed incident MAC. After adjustment, age was the strongest predictor of incident MAC (adjusted OR, 2.25 per 10 yrs; 95% CI, 1.97 to 2.58; P<0.0001). Female gender, white ethnicity, body mass index, diabetes, hypertension, hyperlipidemia, serum cholesterol, smoking, and interleukin-6 were also significant predictors of incident MAC. In participants with prevalent MAC, the median rate of change was 10.1 [IQR, −6.7, 60.7] Agatston units (AU)/year. Baseline MAC severity was the predominant predictor of rate of MAC progression (β-coefficient per 10 AU, 0.88; 95% CI, 0.85 to 0.91; P<0.0001), although ethnicity and smoking status possessed modest influence. Conclusions Several cardiovascular risk factors predicted incident MAC, as did female gender. Severity of baseline MAC was the primary predictor of MAC progression, suggesting that, while atherosclerotic processes may initiate MAC, they are only modestly associated with its progression over these time frames. PMID:24176447

  7. Low-dose fractionated radiotherapy and concomitant chemotherapy for recurrent or progressive glioblastoma. Final report of a pilot study

    Energy Technology Data Exchange (ETDEWEB)

    Balducci, M.; Diletto, B.; Chiesa, S.; D' Agostino, G.R.; Gambacorta, M.A.; Ferro, M.; Valentini, V. [Catholic University of the Sacred Heart, Department of Radiation Oncology, Rome (Italy); Colosimo, C. [Catholic University of the Sacred Heart, Department of Radiology, Rome (Italy); Maira, G.; Anile, C. [Catholic University of the Sacred Heart, Department of Neurosurgery, Rome (Italy)

    2014-04-15

    Evaluated in this study were the feasibility and the efficacy of concurrent low dose fractionated radiotherapy (LD-FRT) and chemotherapy as palliative treatment for recurrent/progressive glioblastoma multiforme (GBM). Eligible patients had recurrent or progressive GBM, Karnofsky performance status ≥70, prior surgery, and standard radiochemotherapy treatment. Recurrence/progression disease during temozolomide (TMZ) received cisplatin (CDDP; 30 mg/m{sup 2} on days 1, 8, 15), fotemustine (FTM; 40 mg/m{sup 2} on days 2, 9, 16), and concurrent LD-FRT (0.3 Gy twice daily); recurrence/progression after 4 months from the end of adjuvant TMZ were treated by TMZ (150/200 mg/m{sup 2} on days 1-5) concomitant with LD-FRT (0.4 Gy twice daily). Primary endpoints were safety and toxicity. A total of 32 patients were enrolled. Hematologic toxicity G1-2 was observed in 18.7% of patients and G3-4 in 9.4%. One patient (3.1%) had complete response, 3 (9.4%) had partial response, 8 (25%) had stable disease for at least 8 weeks, while 20 patients (62.5%) experienced progressive disease. The clinical benefit was 37.5%. Median progression-free survival (PFS) and overall survival (OS) were 5 and 8 months, respectively. Survival rate at 12 months was of 27.8%. LD-FRT and chemotherapy for recurrent/progressive GBM have a good toxicity profile and clinical outcomes, even though further investigation of this novel palliative treatment approach is warranted. (orig.)

  8. Genetics Home Reference: Lafora progressive myoclonus epilepsy

    Science.gov (United States)

    ... Conditions Lafora progressive myoclonus epilepsy Lafora progressive myoclonus epilepsy Enable Javascript to view the expand/collapse boxes. ... Open All Close All Description Lafora progressive myoclonus epilepsy is a brain disorder characterized by recurrent seizures ( ...

  9. Cobalt-doped nanohydroxyapatite: synthesis, characterization, antimicrobial and hemolytic studies

    Energy Technology Data Exchange (ETDEWEB)

    Tank, Kashmira P., E-mail: kashmira_physics@yahoo.co.in [Saurashtra University, Crystal Growth Laboratory, Physics Department (India); Chudasama, Kiran S.; Thaker, Vrinda S. [Saurashtra University, Bioscience Department (India); Joshi, Mihir J., E-mail: mshilp24@rediffmail.com [Saurashtra University, Crystal Growth Laboratory, Physics Department (India)

    2013-05-15

    Hydroxyapatite (Ca{sub 10}(PO{sub 4}){sub 6}(OH){sub 2}; HAP) is a major mineral component of the calcified tissues, and it has various applications in medicine and dentistry. In the present investigation, cobalt-doped hydroxyapatite (Co-HAP) nanoparticles were synthesized by surfactant-mediated approach and characterized by different techniques. The EDAX was carried out to estimate the amount of doping in Co-HAP. The transmission electron microscopy result suggested the transformation of morphology from needle shaped to spherical type on increasing the doping concentration. The powder XRD study indicated the formation of a new phase of brushite for higher concentration of cobalt. The average particle size and strain were calculated using Williamson-Hall analysis. The average particle size was found to be 30-60 nm. The FTIR study confirmed the presence of various functional groups in the samples. The antimicrobial activity was evaluated against four organisms Pseudomonas aeruginosa and Shigella flexneri as Gram negative as well as Micrococcus luteus and Staphylococcus aureus as Gram positive. The hemolytic test result suggested that all samples were non-hemolytic. The photoluminescence study was carried out to identify its possible applicability as a fluorescent probe.

  10. Synthesis, characterization and antimicrobial studies of Schiff base complexes

    Science.gov (United States)

    Zafar, Hina; Ahmad, Anis; Khan, Asad U.; Khan, Tahir Ali

    2015-10-01

    The Schiff base complexes, MLCl2 [M = Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)] have been synthesized by the template reaction of respective metal ions with 2-acetylpyrrole and 1,3-diaminopropane in 1:2:1 M ratio. The complexes have been characterized by elemental analyses, ESI - mass, NMR (1H and 13C), IR, XRD, electronic and EPR spectral studies, magnetic susceptibility and molar conductance measurements. These studies show that all the complexes have octahedral arrangement around the metal ions. The molar conductance measurements of all the complexes in DMSO indicate their non-electrolytic nature. The complexes were screened for their antibacterial activity in vitro against Gram-positive (Streptococcus pyogenes) and Gram-negative (Klebsiella pneumoniae) bacteria. Among the metal complexes studied the copper complex [CuLCl2], showed highest antibacterial activity nearly equal to standard drug ciprofloxacin. Other complexes also showed considerable antibacterial activity. The relative order of activity against S. Pyogenes is as Cu(II) > Zn(II) > Co(II) = Fe(II) > Ni(II) and with K. Pneumonia is as Cu(II) > Co(II) > Zn(II) > Fe(II) > Ni(II).

  11. Cobalt-doped nanohydroxyapatite: synthesis, characterization, antimicrobial and hemolytic studies

    International Nuclear Information System (INIS)

    Hydroxyapatite (Ca10(PO4)6(OH)2; HAP) is a major mineral component of the calcified tissues, and it has various applications in medicine and dentistry. In the present investigation, cobalt-doped hydroxyapatite (Co-HAP) nanoparticles were synthesized by surfactant-mediated approach and characterized by different techniques. The EDAX was carried out to estimate the amount of doping in Co-HAP. The transmission electron microscopy result suggested the transformation of morphology from needle shaped to spherical type on increasing the doping concentration. The powder XRD study indicated the formation of a new phase of brushite for higher concentration of cobalt. The average particle size and strain were calculated using Williamson–Hall analysis. The average particle size was found to be 30–60 nm. The FTIR study confirmed the presence of various functional groups in the samples. The antimicrobial activity was evaluated against four organisms Pseudomonas aeruginosa and Shigella flexneri as Gram negative as well as Micrococcus luteus and Staphylococcus aureus as Gram positive. The hemolytic test result suggested that all samples were non-hemolytic. The photoluminescence study was carried out to identify its possible applicability as a fluorescent probe.

  12. Cortical processing of swallowing in ALS patients with progressive dysphagia--a magnetoencephalographic study.

    Directory of Open Access Journals (Sweden)

    Inga K Teismann

    Full Text Available Amyotrophic lateral sclerosis (ALS is a rare disease causing degeneration of the upper and lower motor neuron. Involvement of the bulbar motor neurons often results in fast progressive dysphagia. While cortical compensation of dysphagia has been previously shown in stroke patients, this topic has not been addressed in patients suffering from ALS. In the present study, we investigated cortical activation during deglutition in two groups of ALS patients with either moderate or severe dysphagia. Whole-head MEG was employed on fourteen patients with sporadic ALS using a self-paced swallowing paradigm. Data were analyzed by means of time-frequency analysis and synthetic aperture magnetometry (SAM. Group analysis of individual SAM data was performed using a permutation test. We found a reduction of cortical swallowing related activation in ALS patients compared to healthy controls. Additionally a disease-related shift of hemispheric lateralization was observed. While healthy subjects showed bilateral cortical activation, the right sensorimotor cortex was predominantly involved in ALS patients. Both effects were even stronger in the group of patients with severe dysphagia. Our results suggest that bilateral degeneration of the upper motor neuron in the primary motor areas also impairs further adjusted motor areas, which leads to a strong reduction of 'swallowing related' cortical activation. While both hemispheres are affected by the degeneration a relatively stronger activation is seen in the right hemisphere. This right hemispheric lateralization of volitional swallowing observed in this study may be the only sign of cortical plasticity in dysphagic ALS patients. It may demonstrate compensational mechanisms in the right hemisphere which is known to predominantly coordinate the pharyngeal phase of deglutition. These results add new aspects to our understanding of the pathophysiology of dysphagia in ALS patients and beyond. The compensational

  13. Fusion-driven actinide burner design study. Second quarterly progress report

    International Nuclear Information System (INIS)

    The Second Quarterly Progress Report summarizes the status at the mid-point of the conceptual design effort. The fusion driver continues to pose some of the principal design problems due to the necessity of advancing plasma engineering and technology for long pulse, high duty cycle operation. The development of credible design solutions to these problems is one of the major objectives of the study. The TF and OH coil designs have been modified to provide a more compact arrangement in the nose region of the TF coils and to ensure fully cryostable operation. A unique concept has been developed to effectively shield the TF coils from the poloidal fields. A vacuum vessel concept which separates the functions for sustaining the differential pressure load and for sealing the vacuum system is described. The thickness of the blanket has been decreased to reduce the power density and the actinide inventory. Determination and presentation of actinide depletion characteristics represents a major element thus far in the study and is a principal objective. Evaluation of the changes in the hazard only during irradiation proved to be an inadequate measure of the reduction in long term hazards due to the importance of radioactive daughter products which appear much later in time. Therefore, comparisons have been made of long term decay characteristics before and after irradiation in the actinide burner. It has also been noted that some of the actinides that are produced during irradiation have beneficial applications as radioisotopic power sources. These and other considerations suggest that alternate approaches to assessing the waste management problem be considered to develop a meaningful perspective on long term hazards from the actinides

  14. Fusion-driven actinide burner design study. Second quarterly progress report

    Energy Technology Data Exchange (ETDEWEB)

    Chi, J.W.H.; Gold, R.E.; Holman, R.R.

    1975-11-01

    The Second Quarterly Progress Report summarizes the status at the mid-point of the conceptual design effort. The fusion driver continues to pose some of the principal design problems due to the necessity of advancing plasma engineering and technology for long pulse, high duty cycle operation. The development of credible design solutions to these problems is one of the major objectives of the study. The TF and OH coil designs have been modified to provide a more compact arrangement in the nose region of the TF coils and to ensure fully cryostable operation. A unique concept has been developed to effectively shield the TF coils from the poloidal fields. A vacuum vessel concept which separates the functions for sustaining the differential pressure load and for sealing the vacuum system is described. The thickness of the blanket has been decreased to reduce the power density and the actinide inventory. Determination and presentation of actinide depletion characteristics represents a major element thus far in the study and is a principal objective. Evaluation of the changes in the hazard only during irradiation proved to be an inadequate measure of the reduction in long term hazards due to the importance of radioactive daughter products which appear much later in time. Therefore, comparisons have been made of long term decay characteristics before and after irradiation in the actinide burner. It has also been noted that some of the actinides that are produced during irradiation have beneficial applications as radioisotopic power sources. These and other considerations suggest that alternate approaches to assessing the waste management problem be considered to develop a meaningful perspective on long term hazards from the actinides.

  15. Quantitative study of myocardial microcirculation in arterial hypertension due to progressive inhibition of NO synthesis

    Directory of Open Access Journals (Sweden)

    Leila Maria Meirelles Pereira

    1999-11-01

    Full Text Available OBJECTIVE: To study the quantitative changes in intramyocardial blood vessels in rats in whom nitric oxide synthesis was inhibited. METHODS: Four groups of 10 rats were studied: control (C25 and C40 and L-NAME (L25 and L40. The animals L25 and L40 received L-NAME in the dosage of 50mg/kg/day for 25 and 40 days, respectively. On days 26 and 41 the animals in groups 25 and 40 were sacrificed. Analysis of the myocardium was performed using light microscopy and stereology. RESULTS: Arterial blood pressure and heart weight increased 74.5 and 57.8% after 25 days and 90.2 and 34.6% after 40 days, respectively. Comparing the L-NAME rats with the respective controls revealed that vessel volume density decreased 31.3% after 40 days, and the vessel length-density decreased 53.5% after 25 days and 25.7% after 40 days. The mean cross-sectional area of the vessels showed an important reduction of 154.6% after 25 days. The intramyocardial vessels decreased significantly in length- density in the L-NAME animals. The mean cross-sectional area of the vessels, which normally increases during heart growth between 25 and 40 days, showed a precocious increase by the 25th day in the L-NAME rats. This suggests an increase of the size of the heart, including blood vessels. CONCLUSION: The inhibition of the NO synthesis provokes rarefaction in the intramyocardial vessels that progresses with the time of administration of L-NAME.

  16. Characterization study of silica aerogel for Cherenkov imaging

    International Nuclear Information System (INIS)

    Different methods to measure the characteristics of silica aerogel tiles used as Cherenkov radiator in the CREAM and AMS experiments have been investigated to optimize the detector performances. The measurement accuracy dictated by the physics objectives on the velocity and charge resolutions set stringent requirements on the aerogel refractive index determination, namely Δn∼1.5x10-4 and Δn∼5x10-4 for the AMS and CREAM imagers, respectively. The matching of such accuracies for this material turned out to be a metrological challenge, and finally led to a full R and D program, to develop an appropriate characterization procedure. Preliminary studies performed with a standard refractive index measurement technique (laser beam deviation by a prism) have revealed a significant systematic index nonuniformity for the AMS tiles at a level (10-3), not acceptable considering the aimed accuracy. These large variations were confirmed in a beam test. A second method, mapping the transverse index gradient by deflection of a laser beam entering normally to the tile has then been developed. It is shown that this procedure is suitable to reach the required accuracy, at the price of using both methods combined. The several hundreds of tiles of the radiator plane of the CREAM and AMS Cherenkov imagers were characterized using a simplified procedure, however, appropriate for each case, compromising between the amount of work and the time available. The experimental procedures and set-ups used are described in the text, and the obtained results are reported.

  17. Characterization study of silica aerogel for Cherenkov imaging

    Science.gov (United States)

    Sallaz-Damaz, Y.; Derome, L.; Mangin-Brinet, M.; Loth, M.; Protasov, K.; Putze, A.; Vargas-Trevino, M.; Véziant, O.; Buénerd, M.; Menchaca-Rocha, A.; Belmont, E.; Vargas-Magaña, M.; Léon-Vargas, H.; Ortiz-Velàsquez, A.; Malinine, A.; Baraõ, F.; Pereira, R.; Bellunato, T.; Matteuzzi, C.; Perego, D. L.

    2010-03-01

    Different methods to measure the characteristics of silica aerogel tiles used as Cherenkov radiator in the CREAM and AMS experiments have been investigated to optimize the detector performances. The measurement accuracy dictated by the physics objectives on the velocity and charge resolutions set stringent requirements on the aerogel refractive index determination, namely Δn˜1.5×10-4 and Δn˜5×10-4 for the AMS and CREAM imagers, respectively. The matching of such accuracies for this material turned out to be a metrological challenge, and finally led to a full R&D program, to develop an appropriate characterization procedure. Preliminary studies performed with a standard refractive index measurement technique (laser beam deviation by a prism) have revealed a significant systematic index nonuniformity for the AMS tiles at a level (10-3), not acceptable considering the aimed accuracy. These large variations were confirmed in a beam test. A second method, mapping the transverse index gradient by deflection of a laser beam entering normally to the tile has then been developed. It is shown that this procedure is suitable to reach the required accuracy, at the price of using both methods combined. The several hundreds of tiles of the radiator plane of the CREAM and AMS Cherenkov imagers were characterized using a simplified procedure, however, appropriate for each case, compromising between the amount of work and the time available. The experimental procedures and set-ups used are described in the text, and the obtained results are reported.

  18. Realisation and subsequent improvements of a progressive wave laser. Application to the study of HFA fluorescence

    International Nuclear Information System (INIS)

    It has been recently shown by Waynant, Shipman, Hogdson and Schafer that, by exciting a gas with a progressive transverse electrical discharge, it is possible to obtain UV and VUV stimulated emissions with short pulse duration. This experimental arrangement is known as a progressive wave laser. At the present time, stimulated emission can be observed with this kind of laser in the following gases: N2 (C3πu → B3πg), CO(A1π → X1Σ), H2[B1Σ → X1Σ) and H2(C1π → X1Σ) at 337, 193, 160 and 120 nm respectively. The short pulse duration and the emission wavelength obtainable with this type of laser has led us to build such a laser and, to study its characteristics. Our laser is composed basically of a 24 cm channel whose discharge width is determined by two T shaped stainless steel electrodes. Our study of the laser characteristics in nitrogen gives the following results: a low resolution measurement of the laser emission, due to the 0-0 band of the N2 second positive System located at 337.1 nm, shows that the output intensity corresponds to 99,9 pc of the total light emitted. A high resolution measurement demonstrates that only the P branches lase. The intensity maxima correspond to the 3 band heads of the P(Ω = 2), P(Ω = 1) and P(Ω = 0) branches. The pulse duration is measured in two different ways and in both cases, the measured value is 1 ns. The energy measurements are made by three different methods: a photo-electrical measurement, microcalorimetry, and Parker's chemical actinometry. These three methods give a mean value of approximately 0.4 mJ (with a 27 kV charge voltage and nitrogen pressure of about 70 torr); in such conditions the emission peak power is about 400 kW. In order to show that this laser is suitable for the excitation and study of short lived fluorescences, it has been used for the measurements of the apparent fluorescence lifetime of HFA (Hexafluoroacetone) at different pressures and several observation wavelengths. This work

  19. Biogeochemical studies of technetium in marine and estuarine ecosystems. Progress report, 1 July 1980-31 July 1981

    International Nuclear Information System (INIS)

    This report summarizes progress from July 1980 through July 1981 on studies dealing with the biogeochemical behavior of technetium in marine and estuarine ecosystems. While the duration of the research has been slightly over two years, the results of our experiments have substantially extended our understanding of the environmental behavior of Tc

  20. New techniques for positron emission tomography in the study of human neurological disorders. Progress report, June 1990--June 1993

    Energy Technology Data Exchange (ETDEWEB)

    Kuhl, D.E.

    1993-06-01

    This progress report describes accomplishments of four programs. The four programs are entitled (1) Faster,simpler processing of positron-computing precursors: New physicochemical approaches, (2) Novel solid phase reagents and methods to improve radiosynthesis and isotope production, (3) Quantitative evaluation of the extraction of information from PET images, and (4) Optimization of tracer kinetic methods for radioligand studies in PET.

  1. Are Substance Use Prevention Programs More Effective in Schools Making Adequate Yearly Progress? A Study of Project ALERT

    Science.gov (United States)

    Clark, Heddy Kovach; Ringwalt, Chris L.; Shamblen, Stephen R.; Hanley, Sean M.; Flewelling, Robert L.

    2011-01-01

    This exploratory study sought to determine if a popular school-based drug prevention program might be effective in schools that are making adequate yearly progress (AYP). Thirty-four schools with grades 6 through 8 in 11 states were randomly assigned either to receive Project ALERT (n = 17) or to a control group (n = 17); of these, 10 intervention…

  2. Study of short-wavelength turbulence in dense plasmas. Annual progress report, September 8, 1981-August 7, 1982

    International Nuclear Information System (INIS)

    A solid-target facility and a Thomson scattering apparatus for the study of laser-induced turbulence has been constructed and tested. Initial problems with prelase have been overcome. In an ongoing experiment on the saturation of SBS, considerable progress has been made in the form of streaked Thomson scattering data on the space and time behavior of the ion wave

  3. Does the Glass Ceiling Exist? A Longitudinal Study of Women’s Progress on French Corporate Boards

    OpenAIRE

    Rey Dang; Duc Khuong Nguyen; Linh-Chi Vo

    2014-01-01

    In this article, we conduct a longitudinal study of women’s progress on French corporate boards of directors. We particularly focus on the extent to which women directors have circumvented the glass ceiling. Using a sample of SBF 120 companies over a 10

  4. Eradication of Helicobacter pylori Is Associated with the Progression of Dementia: A Population-Based Study

    Directory of Open Access Journals (Sweden)

    Yang-Pei Chang

    2013-01-01

    Full Text Available Objective. To evaluate the effect of eradication of Helicobacter pylori (H. pylori on the progression of dementia in Alzheimer’s disease (AD patients with peptic ulcer. Methods. Participants with the diagnosis of AD and peptic ulcer were recruited between 2001 and 2008. We examined the association between eradication of H. pylori and the progression of AD using the multiple regression models. Medication shift from Donepezil, Rivastgmine, and Galantamine to Mematine is defined as progression of dementia according to the insurance of National Health Insurance (NHI under expert review. Results. Among the 30142 AD patients with peptic ulcers, the ratio of medication shift in AD patients with peptic ulcers is 79.95%. There were significant lower incidence comorbidities (diabetes mellitus, hypertension, cerebrovascular disease, coronary artery disease, congestive heart failure and hyperlipidemia in patients with H. pylori eradication as compared with no H. pylori eradication. Eradication of H. pylori was associated with a decreased risk of AD progression (odds ratio [OR] 0.35 [0.23–0.52] as compared with no H. pylori eradication, which was not modified by comorbidities. Conclusions. Eradication of H. pylori was associated with a decreased progression of dementia as compared to no eradication of H. pylori in AD patients with peptic ulcers.

  5. Progressive Neuronal Degeneration of Childhood with Liver's Disease (Alpers' Disease) Clinical Features and Neuropathological Studies of 4 Sibling

    Institute of Scientific and Technical Information of China (English)

    Yupu Guo; Zhong Guo; Haowen Liu; Mingwe Wang; Hongwei Duan; Shufang Gao; Haitao Ren

    2000-01-01

    We report four siblings of a family with Alpers' disease. Three of four siblings occurred diarrhea and myoclonus at the ages of 7 to 8 years old. During the disease evolution, symptoms of subacute encephalopathy such as headache, visual disturbance, cortical blindness, progressive seizures and mental retardation were presented at the ages of 15 to 20 years old. Downhill progression led them to death in multiple organ failure within six to eight months of onset. CT showed hypodensity lesions in the bilateral oc cipital and temporal lobes. Spongiform changes, which characterized by diffuse neuronal degeneration or loss and astrocytosis, were most severe in the gray matter. White matter was slightly involved, while basal ganglia, pons, brain stem and cerebellum were not involved. Physical examination of the only live brother of the four siblings showed short status (165 cm), arched feet and improper nose-pointed test of the left side. Muscle biopsy of him showed a large amount of Red-Ragged (RR) fibers and abnormal mitochondria. Clinical features and pathological findings of autopsy in all the four siblings were consistent with progressive neuronal degeneration of childhood with liver disease (PNDC) - Alpers' disease. The muscle biopsy showed the characteristic findings of mitochondrial myopathy. Our report confirmed the classification of late onset Alpers' disease as a mitochondrial disorders.

  6. Nuclear medicine and imaging research. Quantitative studies in radiopharmaceutical science. Comprehensive progress report, January 1, 1983-June 30, 1985

    International Nuclear Information System (INIS)

    This comprehensive report outlines the progress made during the past three years in the areas described below. In all instances, initial studies have been carried out and the technical feasibility of carrying through each study has been demonstrated. The studies described include development of cesium-130 and bromine-75 radioisotope generators, the feasibility of using rubidium-82 as a myocardial imaging agent, and radiochemical preparation of C-11 deoxyglucose. 28 refs. (DT)

  7. Characterizing parameters of Jatropha curcas cell cultures for microgravity studies

    Science.gov (United States)

    Vendrame, Wagner A.; Pinares, Ania

    2013-06-01

    Jatropha (Jatropha curcas) is a tropical perennial species identified as a potential biofuel crop. The oil is of excellent quality and it has been successfully tested as biodiesel and in jet fuel mixes. However, studies on breeding and genetic improvement of jatropha are limited. Space offers a unique environment for experiments aiming at the assessment of mutations and differential gene expression of crops and in vitro cultures of plants are convenient for studies of genetic variation as affected by microgravity. However, before microgravity studies can be successfully performed, pre-flight experiments are necessary to characterize plant material and validate flight hardware environmental conditions. Such preliminary studies set the ground for subsequent spaceflight experiments. The objectives of this study were to compare the in vitro growth of cultures from three explant sources (cotyledon, leaf, and stem sections) of three jatropha accessions (Brazil, India, and Tanzania) outside and inside the petriGAP, a modified group activation pack (GAP) flight hardware to fit petri dishes. In vitro jatropha cell cultures were established in petri dishes containing a modified MS medium and maintained in a plant growth chamber at 25 ± 2 °C in the dark. Parameters evaluated were surface area of the explant tissue (A), fresh weight (FW), and dry weight (DW) for a period of 12 weeks. Growth was observed for cultures from all accessions at week 12, including subsequent plantlet regeneration. For all accessions differences in A, FW and DW were observed for inside vs. outside the PetriGAPs. Growth parameters were affected by accession (genotype), explant type, and environment. The type of explant influenced the type of cell growth and subsequent plantlet regeneration capacity. However, overall cell growth showed no abnormalities. The present study demonstrated that jatropha in vitro cell cultures are suitable for growth inside PetriGAPs for a period of 12 weeks. The parameters

  8. Production, progress and applications of the GridPix Gaseous Pixel Detector: characterizing discharge protection and improving drift time resolution

    International Nuclear Information System (INIS)

    GridPix detectors operated succesfully during a testbeam period at CERN in October 2010. Low cost industrial production is under development. The process of discharge quenching has been studied, as well as time slewing effects. New applications of GridPix-readout TPCs are presented.

  9. Characterization, antioxidant potential and cytotoxic study of mangaba fruits

    Directory of Open Access Journals (Sweden)

    Carolina Fagundes Assumpção

    2014-07-01

    Full Text Available The mangaba (Hancornia speciosa stands out and has a great potential for economic exploitation and researches have suggested relevant results regarding the nutritional and functional value of this food. Therefore, the objective of this study was to chemically and physicochemically characterize the mangaba fruit harvested in the Middle Araguaia region. It was evaluated the chemical composition, antioxidant activity, volatile compounds, preliminary photochemical studies of phenolic components and the cytotoxic potential of ethanolic extract fruits against Artemia salina. The mean pH, the total titratable acidity and the value for reducing sugars conclude that the mangaba possesses the characteristics appropriate for both fresh consumption and for processing. Between the mean values measured, the fruits presented high fiber content and a low caloric value. The analysis of the antioxidant potential revealed a significant activity and in the volatile compounds analysis, esters were the major class presents. The result of the phytochemical screening revealed that phenols, flavonoids and tannins were present in the ethanolic extract of mangaba and a significant activity in the cytotoxicity assay was observed.

  10. Wastewater characterization of IPEN facilities - a preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, Lucilena R.; Goncalves, Cristina; Terazan, Wagner R.; Cotrim, Marycel E.B.; Pires, Maria Aparecida F., E-mail: lrmonteiro@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    As part of IPEN's Environmental Monitoring Program, wastewater sample collection and analysis was implemented on a daily basis. CQMA- Centro de Quimica e Meio Ambiente was responsible for the determination of total, fixed and volatile solids, pH, metals (as Al, Sb, Ba, Cd, Pb, Co, Cu, Cr, Hg, Mo, Ni, Ag, Na, Zn, Ca, Mg, Be, Sn, Li, K, Sr, Ti and V), semimetals (As, B, Se and Si) and anions (such as chloride, nitrate, sulfate and fluoride). The results were compared to the legal values established by the Sao Paulo State regulation 8,468/76, which defines the maximum permitted values for most of the studied substances in wastewater, aiming its releasing in public wastewater treatment system. The evaluation of this parameters concentration on Ipen's effluent implies that 50% of the wastewater corresponds to organic matter due to the sanitary load and inorganic macro elements, mainly as sodium, potassium, calcium. The only parameter not found in accordance with Brazilian legislation was pH in four out of the one hundred and seven samples collected throughout 2009 (2.8% of the samples analyzed). This preliminary study showed the effluents generated at Ipen's facility is characterized by the presence of organic matter and macro elements, commonly found in sanitary wastewater and it is in compliance with Sao Paulo regulations. (author)

  11. Progress in conceptual study of China fusion-based hydrogen production reactor

    International Nuclear Information System (INIS)

    Full text: As one of the series of fusion system design concepts developed by the FDS Team of China, Fusion-based hydrogen production reactor (FDS-III) is designated to exploit the fusion energy advanced application for the production of hydrogen, and satisfy fusion development strategy in China. FDS-III is a cost competitive reactor concept with a fusion power of ∼2.5GW, whose parameters are selected based on the progress in recent magnetic confinement fusion. The neutron wall load of 3.5∼4MW/m2 and the surface heat flux of ∼0.8MW/m2 are considered. for high effective energy conversion. An innovative high temperature liquid lithium-lead blanket (HTL) concept based on the Reduced Activation Ferritic-Martensitic steel (RAFM) as structural material is proposed as an option of the blanket concepts for FDS-III. The 'multilayer flow channel inserts (MFCIs)' have been adopted in the LiPb channels to attain high outlet temperature about 1000 deg C to satisfy the need of high efficiency production of hydrogen. The blanket combines advantage of the banana segment and large module to improve maintenance efficiency and reduce effect of electric magnetic force. The maintenance scheme considered is based on the removal of blanket segment and divertor cassettes through the big equatorial ports. In order to achieve a high energy conversion system, a carbon dioxide Brayton cycle is adopted which permit a high thermal efficiency. Preliminary cost analysis show FDS-III is a competition fusion reaction for hydrogen production. This paper gives the preliminary design and study of FDS-III. (author)

  12. Study of mechanism of hydrogen diffusion in separation devices. Progress report for 1980-1983

    International Nuclear Information System (INIS)

    For the purpose of studying the mechanisms of hydrogen diffusion in separation devices e.g. transition-metal membranes, we have developed a microscopic dynamic model appropriate for describing the nonequilibrium statistical mechanics of hydrogen-in-a-metal. Using this model we have carried out a detailed analysis to obtain the autocorrelation function of density fluctuations in the model. Our model is built on the physical idea that, at low temperatures, spin clusters are the basic units or aggregates of transport. Our work can explain the reversed isotope effect in diffusion. We have also obtained an expression for the relative diffusivity, verifiable by experiments with tritium in metals. Our notion of spin clusters is novel. There is some evidence of their existence. The interstitial spin clusters are comparable to atomic and nuclear spin clusters, the only other natural spin clusters. Our demonstration of a long-time tail in the autocorrelation function is also novel. Diffusion can be anomalous if long time tails exist, a current topic in nonlinear behavior of fluids and solids. Our progress has been made possible by our development in the mathematical method of solving the generalized Langevin equation. This method is applicable to any time-dependent quantum many-body model. The underlying basis of this method is our discovery of a new orthogonalization process in Hilbert space, first since Gram and Schmidt over 100 years ago. Our process is simpler if Hilbert space is realized as is for all physical problems. To demonstrate the power and utility of our method we considered a well established model of metals, thereby discovering the existence of a low-frequency electronic mobility. This kind of intrinsic conductivity should exist in ensembles of all light particles, hence also relevant to hydrogen and its isotopes in metals

  13. H MR spectroscopy in Parkinson's disease and progressive supranuclear palsy : preliminary study

    International Nuclear Information System (INIS)

    To determine whether h magnetic resonance spectroscopy (MRS) is useful in differentiating idiopathic Parkinson's disease (IPD) from progressive supranuclear palsy (PSP), based on metabolite ratios. Using a 1.5 T MR Unit, single voxel H MRS using STEAM with a TR of 2000 ms and a TE of 135ms was performed in seven PD and eight PSP patients. Five age-matched volunteers(mean age, 63 years) and another five younger healthy volunteers(mean age, 30 tears) were studied as normal controls. The regions of interest were the putamen and pallidum, with a size of 2X2X2 cm. After measuring the spectral intensities of each metabolite (N-acetylaspartate=NAA, choline=Cho, creatine=Cr and lactate), relative peak height ratios of NAA/Cr, Cho/Cr and NAA/ Cho, and lactate levels among four groups were compared. NAA/ Cho and NAA/ Cr ratios were statistically lower in the PSP group than the IPD group (1.21 ± 0.26 versus 1.45 ± 0.20, and 1.26 ± 0.23 versus 1.38 ± 0.19, respectively : p0.05). Cho/Cr ratios were not different among four groups. Lactate was not detected in any patients. NAA/Cho and NAA/Cr ratios in the corpus stratum were significantly lower in the PSP group than in the age-matched control and IPD groups. These results suggest that loss of neuron cells in the corpus stratum is more prominent in PSP than in IPD, and that NAA/Cho and NAA/Cr ratios may help in differential diagnosis of IPD and PSP

  14. New insights into Alzheimer's disease progression: a combined TMS and structural MRI study.

    Directory of Open Access Journals (Sweden)

    Eini Niskanen

    Full Text Available BACKGROUND: Combination of structural and functional data of the human brain can provide detailed information of neurodegenerative diseases and the influence of the disease on various local cortical areas. METHODOLOGY AND PRINCIPAL FINDINGS: To examine the relationship between structure and function of the brain the cortical thickness based on structural magnetic resonance images and motor cortex excitability assessed with transcranial magnetic stimulation were correlated in Alzheimer's disease (AD and mild cognitive impairment (MCI patients as well as in age-matched healthy controls. Motor cortex excitability correlated negatively with cortical thickness on the sensorimotor cortex, the precuneus and the cuneus but the strength of the correlation varied between the study groups. On the sensorimotor cortex the correlation was significant only in MCI subjects. On the precuneus and cuneus the correlation was significant both in AD and MCI subjects. In healthy controls the motor cortex excitability did not correlate with the cortical thickness. CONCLUSIONS: In healthy subjects the motor cortex excitability is not dependent on the cortical thickness, whereas in neurodegenerative diseases the cortical thinning is related to weaker cortical excitability, especially on the precuneus and cuneus. However, in AD subjects there seems to be a protective mechanism of hyperexcitability on the sensorimotor cortex counteracting the prominent loss of cortical volume since the motor cortex excitability did not correlate with the cortical thickness. Such protective mechanism was not found on the precuneus or cuneus nor in the MCI subjects. Therefore, our results indicate that the progression of the disease proceeds with different dynamics in the structure and function of neuronal circuits from normal conditions via MCI to AD.

  15. Crosswell electromagnetic imaging for geothermal reservoir characterization - a feasibility study

    Science.gov (United States)

    Samrock, Friedemann; Saar, Martin O.

    2016-04-01

    Most regions in the world do not have ready access to natural convective hydrothermal resources. To use deep geothermal heat as a viable energy resource in low-permeability formations, permeable fracture networks have to be created artificially to enable deep fluid circulation for advective heat transport to a production well. Such generation of enhanced geothermal systems (EGS) is studied in the "Deep Underground Geothermal (DUG)" laboratory at the Grimsel pass, Switzerland. Here, an underground experiment is conducted by hydraulically stimulating a pre-existing shear zone within crystalline rock. The objectives of this project are to better describe and understand the processes acting during reservoir generation. We perform a feasibility study to evaluate the capability of low-frequency crosswell electromagnetic (EM) tomography for mapping of stimulation-induced changes in electrical conductivity. First numerical results show that crosswell EM data are generally sensitive to the inter-well conductivity distribution, which is affected by properties such as interconnected porosity, permeability and the presence of fluids. It thereby provides important information for characterization of potential EGS reservoirs. We present a 3-D forward modeling and inversion study using synthetic data and under realistic conditions, these include the true borehole spacing and the observed electromagnetic noise level in the DUG laboratory. Based on these results we discuss the system requirements and the capability of crosswell EM to recover the inter-well structure and stimulation-induced changes. Besides the numerical study we report on the current status of instrumentation and realization of crosswell EM measurements at the DUG laboratory.

  16. JSFR design study and R and D progress in the FaCT project

    International Nuclear Information System (INIS)

    . As for the beyond design basis events (BDBEs),Self Actuated Shutdown System (SASS) and natural circulation capability are provided for reactor shutdown and decay heat removal, respectively, to prevent the accident progression into core disruptive accidents. Furthermore, efforts have been made to avoid the severe energetics due to excursion by restricting the core design and providing the inner duct structures in the fuel subassembly to enhance the molten fuel discharge, so that the in-vessel retention capability can be reinforced providing the multiple layer core catchers. Research and development on the innovative technologies has been in progress, and the results are being obtained and reflected into the design of JSFR. Design measures to prevent the vibration and wear of IHX tubes attributed to the mechanical vibration of the primary pump have been evaluated. The results of water tests on the in-vessel thermal-hydraulics have been reflected to take measures for the RV design to overcome gas entrainment and vortex-induced cavitations. Mechanical testing studies have been performed with a full scale mock-up test device of the new FHM to confirm the basic functions. Trial manufacturing for the components of the double-walled tube SG and development of an under sodium viewer technology for inspection of the reactor internal have been also progressing. To demonstrate the innovative technologies, a plan of a large-scale sodium test complex has been started to develop and demonstrate the function of the reactor components and the cooling systems. In the FaCT project an international collaboration is emphasized to explore the possibilities of sharing and/or collaborating in the development of the innovative technologies. Generation-IV International Forum is a representative multilateral collaboration framework where Japan has played an active and leading role in cooperation on especially sodium-cooled fast reactor system. International Project on Innovative Nuclear

  17. Physical--chemical studies of transuranium elements. Progress report, April 1, 1976--March 31, 1977

    International Nuclear Information System (INIS)

    Major advances in our continuing program to determine, interpret, and correlate the basic chemical and physical properties of the transuranium elements are summarized for the period April 1, 1976, through March 31, 1977. Implementation of data reduction programs and acquisition of a CRT time-sharing graphics terminal/stand-alone computer have advanced significantly the handling capabilities of single-beam spectral data obtained by our microscope spectrophotometer. EsCl3, EsBr3, and EsI3 have been well characterized spectroscopically, and limited X-ray diffraction data have been obtained from EsBr3 and EsI3. The reduction of mixed Es-lanthanide trihalides has produced what might be Es(II). Dimorphism in BkCl3, CfCl3, and BkBr3 has been studied spectrophotometrically and the results confirmed by X-ray analysis. Our solution microcalorimeter was improved by reducing the system-generated electrical noise and developing a novel sample container. The operating sensitivity was determined to be within the desired 0.1 percent precision requirement. The necessary hardware was obtained and software development was initiated for the capability to acquire, store, and analyze the heat of solution data automatically. A very sensitive apparatus (SQUID) for the determination of magnetic susceptibility has been constructed and is being evaluated. Our device should greatly facilitate the study of microgram-sized samples of transuranium elements and compounds

  18. The molecular characterization of the lignin-forming peroxidase. Progress summary report, April 1, 1992--March 31, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Lagrimini, L.M.

    1995-06-01

    My research program focuses entirely on the study of the lignin-forming peroxidase of tobacco. Ever since our cloning and sequencing of the first plant peroxidase cDNA, we have pioneered in the introduction of the tools of molecular biology to the study of plant peroxidases. A significant part of our effort has been focused on the construction and analysis of transgenic plants which either over- or under-express the tobacco anionic peroxidase. This research has not only supported the role for this enzyme in lignification, but has opened the door to our understanding of additional metabolic functions including auxin metabolism and insect defense. As you will learn, this enzyme`s role in auxin catabolism has lead to numerous phenotypes in transgenic plants. More recently, our attention has been directed towards the analysis of peroxidase gene expression. From this work we have learned that the anionic peroxidase gene is expressed at high levels in the xylem-forming cells, epidermis, and trichomes. This expression pattern supports its role lignification and hose defenses. We have also learned that this gene is down-regulated by auxin which indicates a strong relationship between auxin and the anionic peroxidase. 12 figs.

  19. Characterization of a Novel Murine Model to Study Zika Virus

    Science.gov (United States)

    Rossi, Shannan L.; Tesh, Robert B.; Azar, Sasha R.; Muruato, Antonio E.; Hanley, Kathryn A.; Auguste, Albert J.; Langsjoen, Rose M.; Paessler, Slobodan; Vasilakis, Nikos; Weaver, Scott C.

    2016-01-01

    The mosquito-borne Zika virus (ZIKV) is responsible for an explosive ongoing outbreak of febrile illness across the Americas. ZIKV was previously thought to cause only a mild, flu-like illness, but during the current outbreak, an association with Guillain–Barré syndrome and microcephaly in neonates has been detected. A previous study showed that ZIKV requires murine adaptation to generate reproducible murine disease. In our study, a low-passage Cambodian isolate caused disease and mortality in mice lacking the interferon (IFN) alpha receptor (A129 mice) in an age-dependent manner, but not in similarly aged immunocompetent mice. In A129 mice, viremia peaked at ∼107 plaque-forming units/mL by day 2 postinfection (PI) and reached high titers in the spleen by day 1. ZIKV was detected in the brain on day 3 PI and caused signs of neurologic disease, including tremors, by day 6. Robust replication was also noted in the testis. In this model, all mice infected at the youngest age (3 weeks) succumbed to illness by day 7 PI. Older mice (11 weeks) showed signs of illness, viremia, and weight loss but recovered starting on day 8. In addition, AG129 mice, which lack both type I and II IFN responses, supported similar infection kinetics to A129 mice, but with exaggerated disease signs. This characterization of an Asian lineage ZIKV strain in a murine model, and one of the few studies reporting a model of Zika disease and demonstrating age-dependent morbidity and mortality, could provide a platform for testing the efficacy of antivirals and vaccines. PMID:27022155

  20. Characterization of a Novel Murine Model to Study Zika Virus.

    Science.gov (United States)

    Rossi, Shannan L; Tesh, Robert B; Azar, Sasha R; Muruato, Antonio E; Hanley, Kathryn A; Auguste, Albert J; Langsjoen, Rose M; Paessler, Slobodan; Vasilakis, Nikos; Weaver, Scott C

    2016-06-01

    The mosquito-borne Zika virus (ZIKV) is responsible for an explosive ongoing outbreak of febrile illness across the Americas. ZIKV was previously thought to cause only a mild, flu-like illness, but during the current outbreak, an association with Guillain-Barré syndrome and microcephaly in neonates has been detected. A previous study showed that ZIKV requires murine adaptation to generate reproducible murine disease. In our study, a low-passage Cambodian isolate caused disease and mortality in mice lacking the interferon (IFN) alpha receptor (A129 mice) in an age-dependent manner, but not in similarly aged immunocompetent mice. In A129 mice, viremia peaked at ∼10(7) plaque-forming units/mL by day 2 postinfection (PI) and reached high titers in the spleen by day 1. ZIKV was detected in the brain on day 3 PI and caused signs of neurologic disease, including tremors, by day 6. Robust replication was also noted in the testis. In this model, all mice infected at the youngest age (3 weeks) succumbed to illness by day 7 PI. Older mice (11 weeks) showed signs of illness, viremia, and weight loss but recovered starting on day 8. In addition, AG129 mice, which lack both type I and II IFN responses, supported similar infection kinetics to A129 mice, but with exaggerated disease signs. This characterization of an Asian lineage ZIKV strain in a murine model, and one of the few studies reporting a model of Zika disease and demonstrating age-dependent morbidity and mortality, could provide a platform for testing the efficacy of antivirals and vaccines. PMID:27022155

  1. Studies on virus-induced cell fusion. Progress report, May 1, 1976--July 31, 1977

    Energy Technology Data Exchange (ETDEWEB)

    Person, S.

    1977-01-01

    The cell fusion process of Herpes simplex virus has been characterized as regards macromolecular synthesis and post-macromolecular synthesis events. Studies with actinomycin D revealed that the critical period for RNA synthesis associated with cell fusion was 2 to 4 hr after infection, studies with cycloheximide showed that the critical period for protein synthesis was 3 to 5.5 hr after infection, and studies with 2-deoxyglucose showed that the critical period for glycosylation was 5 to 7 hr after infection. NH/sub 4/Cl and 2-adamantanone block events that occur subsequently (5.5 to 8 hr after infection). A temperature-sensitive step in fusion occurs from 4 to 6 hr after infection. Phosphonoacetic acid, a specific inhibitor of viral DNA synthesis, inhibits fusion only at a low MOI. Even in this case it decreases the rate but not the amount of fusion (if the kinetics curves are extended to sufficiently long times). There is no effect of phosphonoacetic acid at MOIs greater than 10 PFU/cell. Presumably the transcription and translation of 10 viral genomes/cell are required to achieve the maximum rate of fusion. 2-adamantanone partitions efficiently into cellular membranes and increases their fluidity. The effect of 2-adamantanone on cell fusion and on virus growth as well as its effect on the physical state of membranes has been studied extensively during the past year. Although 2-adamantanone does not inactivate mature virions, it does inhibit virus growth almost completely at the same concentration (5 mM). The molecular event sensitive to 2-adamantanone occurs late in viral infection and is at least partially reversible.

  2. Retrospective study of the effect of disease progression on patient reported outcomes in HER-2 negative metastatic breast cancer patients

    Directory of Open Access Journals (Sweden)

    Yu Elaine

    2011-06-01

    Full Text Available Abstract Background This retrospective study evaluated the impact of disease progression and of specific sites of metastasis on patient reported outcomes (PROs that assess symptom burden and health related quality of life (HRQoL in women with metastatic breast cancer (mBC. Methods HER-2 negative mBC patients (n = 102 were enrolled from 7 U.S. community oncology practices. Demographic, disease and treatment characteristics were abstracted from electronic medical records and linked to archived Patient Care Monitor (PCM assessments. The PCM is a self-report measure of symptom burden and HRQoL administered as part of routine care in participating practices. Linear mixed models were used to examine change in PCM scores over time. Results Mean age was 57 years, with 72% of patients Caucasian, and 25% African American. Median time from mBC diagnosis to first disease progression was 8.8 months. Metastasis to bone (60%, lung (28% and liver (26% predominated at initial metastatic diagnosis. Results showed that PCM items assessing fatigue, physical pain and trouble sleeping were sensitive to either general effects of disease progression or to effects associated with specific sites of metastasis. Progression of disease was also associated with modest but significant worsening of General Physical Symptoms, Treatment Side Effects, Acute Distress and Impaired Performance index scores. In addition, there were marked detrimental effects of liver metastasis on Treatment Side Effects, and of brain metastasis on Acute Distress. Conclusions Disease progression has a detrimental impact on cancer-related symptoms. Delaying disease progression may have a positive impact on patients' HRQoL.

  3. Study on multipartite quantum states: preparation, simulation, and characterization

    International Nuclear Information System (INIS)

    In this thesis different problems are investigated related to the description as well as the manipulation of multipartite quantum states. Because of the superposition principle, the state of a composite quantum system can be entangled, i.e. exhibit quantum correlations between the sites. The entanglement of two-qubit systems is well understood. There is only one kind of entanglement which can be directly related to the value of the Schmidt coefficients. However this is not the case for multipartite entanglement of qubit systems. Unlike in the two-qubit case, a multipartite quantum state can be entangled in many different ways, which complicates the classification and characterization of such states. The storage and manipulation of a quantum state is a challenging task because of the decoherence resulting from the interaction of the state with its environment. One way to overcome this difficulty is to use entanglement purification which will be the subject of the first part of this thesis. Entanglement purification allows to extract a small number of nearly pure states out of a bigger set of mixed states. We review existing bipartite and multipartite entanglement purification protocols and introduce new protocols which are capable of purifying any graph state, enlarging by this the class of states which can be purified. The second part deals with the preparation and distribution of high-fidelity multi-party entangled states via noisy channels and operations. In the particular case of GHZ and cluster states, we study different strategies using bipartite or multipartite purification protocols. The most efficient strategy depends on the target fidelity one wishes to achieve and on the quality of transmission channel and local operations. We show the existence of a crossing point beyond which the strategy making use of the purification of the state as a whole is more efficient than a strategy in which pairs are purified before they are connected to the final state. We

  4. Studies in iodine metabolism: monitoring of animal thyroids. Progress report, 1984-1985

    International Nuclear Information System (INIS)

    This progress report briefly summarizes the counting and re-counting of domestic or wild animal thyroids from the United Kingdom, Federal Republic of Germany, the reservation of the Savannah River Plant, or from the DOE reservation at Oak Ridge. The possible effect that a mycotoxin may have an iodine deficiency was investigated. 3 refs., 3 figs., 4 tabs. (DT)

  5. Studies of human mutation rates. Progress report, November 1992--October 1993

    Energy Technology Data Exchange (ETDEWEB)

    Neel, J.V.; Hanash, S.M.

    1993-10-27

    The progress during 1992--1993 with respect to ER 60533 is summarized in this report under three headings: The development of two-dimensional DNA gels for the detection of mutation, the mitochondrial DNA of American Indians, and molecular verification of a suggested polyogeny for the eight most common phospheglucomutose-1 (POM1)alleles.

  6. Experimental studies of elementary particle interactions at high energies: Technical progress report

    International Nuclear Information System (INIS)

    This paper discusses progress of experiments at CERN and Fermilab. At CERN, data accumulation and analysis is discussed for the UA-6 experiment, which involves proton-antiproton collisions. At Fermilab, the testing of a collider detector for the Tevatron is discussed

  7. Basic studies of atomic dynamics. Progress report, July 1, 1982-August 31, 1983

    Energy Technology Data Exchange (ETDEWEB)

    Fano, U.

    1983-08-31

    The observed but puzzling stability of resonant states a stride potential ridges is shown to reflect a general self-focussing property of convergent waves. An approach to the solution of nonseparable wave equations is introduced which utilizes their separability in asymptotic limits. Progress is outlined in describing the properties of N-electron atoms in highly condensed states.

  8. Biological characterization of radiation exposure and dose estimates for inhaled uranium milling effluents. Annual progress report, April 1981-March 1982

    International Nuclear Information System (INIS)

    The problems addressed are the protection of uranium will workers from occupational exposure to uranium through routine bioassay programs and the assessment of accidental worker exposures. Comparisons of chemical properties and the biological behavior of refined uranium ore (yellowcake) are made to identify important properties that influence uranium distribution patterns among organs. These studies will facilitate calculations of organ doses for specific exposures and associated health risk estimates and will identify important bioassay procedures to improve evaluations of human exposures. Sampling of airborne yellowcake at four uranium mills showed that aerosols were heterogeneous, changed with time and contained approx. 50% of the airborne uranium in particles greater than 12 μm aerodynamic diameter. Results are related to specific packaging steps and to predictions of appreciable upper respiratory tract deposition rates for the aerosols, if inhaled by a worker without respiratory protection. Previously used in vitro dissolution techniques were evaluated and the uses of the results for interpreting urinary bioassay data are described. Preliminary results from an inhalation experiment using rats indicate that the clearance patterns of inhaled uranium from lung agreed quantitatively with results from in vitro dissolution and infrared analyses of the yellowcake used. Preliminary results from an experiment to simulate contamination of a wound by yellowcake showed that more of the implanted dose of a less soluble form of yellowcake was retained at the wound site than of a more soluble form at 32 days after implantation. The results did not quantitatively agree with in vitro dissolution results. A two-year study of yellowcake from two mills was initiated. Twenty Beagle dogs were exposed by nose-only inhalation to a more soluble form of yellowcake and 20 to a less soluble form

  9. Antenna coupling study for ICWC plasma characterization in TEXTOR

    Indian Academy of Sciences (India)

    Manash Kumar Paul; A Lyssoivan; R Koch; G Van Wassenhove; M Vervier; G Bertschinger; R Laengner; B Unterberg; G Sergienko; V Philipps; T Wauters; the TEXTOR Team

    2013-01-01

    Ion cyclotron wall conditioning (ICWC) discharges, in pulsed-mode operation, were carried out in the limiter tokamak TEXTOR to explore safe operational regimes for the experimental parameters for possible ICWC-discharge cleaning in International Thermonuclear Experimental Reactor (ITER) at half field. Antenna coupling properties obtained during the ion cyclotron range of frequencies (ICRF) wall conditioning experiments performed in helium–hydrogen mixture in TEXTOR were analysed in relation to the obtained ICWC-plasma characterization results. Satisfactory antenna coupling in the mode conversion scenario along with reproducible generation of ICRF plasmas for wall conditioning, were achieved by coupling radio frequency (RF) power from one or two ICRF antennas. The plasma breakdown results obtained in the TEXTOR tokamak have been compared with the predictions of a zero-dimensional RF plasma production model. The present study of ICWC emphasizes the beneficial effect of application of an additional (along with toroidal magnetic field) stationary vertical ($B_{V} \\ll B_{T}$) or oscillating poloidal magnetic field ($B_{P} \\ll B_{T}$) on antenna coupling and relevant plasma parameters.

  10. Synthesis, characterization, and electrical properties studies of cadmium selenide nanoparticle

    Science.gov (United States)

    Seoudi, R.; Elokr, M. M.; Shabaka, A. A.; Sobhi, A.

    2008-01-01

    A new solvothermal route was used for the preparation of CdSe nanoparticles at 160 °C for 10 h using ethylenediamine as a solvent. X-ray powder diffraction and transmission electron microscope were employed to characterize the size, morphology, and crystalline structure of the as-prepared sample. The formation process was discussed and it revealed a uniform hexagonal shape of CdSe nanoparticle with good dispersion, with an average size of 35 nm. Fourier transform infrared and ultraviolet-visible spectroscopies were used to follow the reaction and to determine the optical band gap. DC and AC electrical conductivities were studied and the activation energies were determined as well as the conduction mechanism. The results indicated that CdSe behaves as a semiconducting material. The dielectric properties were measured as a function of temperature at different frequencies ranging from 100 Hz to 100 kHz. The increase of the dielectric constant with increasing temperature was discussed on the basis of increasing polarizability, while its decrease with increasing frequency is attributed to the dielectric dispersion.

  11. Synthesis, characterization, and electrical properties studies of cadmium selenide nanoparticle

    International Nuclear Information System (INIS)

    A new solvothermal route was used for the preparation of CdSe nanoparticles at 160 deg. C for 10 h using ethylenediamine as a solvent. X-ray powder diffraction and transmission electron microscope were employed to characterize the size, morphology, and crystalline structure of the as-prepared sample. The formation process was discussed and it revealed a uniform hexagonal shape of CdSe nanoparticle with good dispersion, with an average size of 35 nm. Fourier transform infrared and ultraviolet-visible spectroscopies were used to follow the reaction and to determine the optical band gap. DC and AC electrical conductivities were studied and the activation energies were determined as well as the conduction mechanism. The results indicated that CdSe behaves as a semiconducting material. The dielectric properties were measured as a function of temperature at different frequencies ranging from 100 Hz to 100 kHz. The increase of the dielectric constant with increasing temperature was discussed on the basis of increasing polarizability, while its decrease with increasing frequency is attributed to the dielectric dispersion

  12. Photochemical energy storage: studies of inorganic photoassistance agents. Progress report, December 17, 1979-March 31, 1981

    Energy Technology Data Exchange (ETDEWEB)

    Wrighton, M. S.

    1980-12-01

    Research progress has been made in the study of p-type semiconductor (photocathode) electrode materials. A number of small band gap (E/sub g/ approximately equal to 1.1 to 1.4 eV) p-type semiconductors have been demonstrated to have poor H/sub 2/ evolution kinetics despite the fact that a reasonable output photovoltage (E/sub V/) compared to E/sub g/ could be expected. Special emphasis has been on p-type Si (E/sub g/ = 1.1 eV) and p-type InP (E/sub g/ = 1.35 eV). Both of these materials give poor kinetics for H/sub 2/ evolution from H/sub 2/O, while the kinetics for N,N'-dimethyl-4,4'-bipyridinium, MV/sup 2 +/, reduction to MV/sup +/ are good at a pH where E/sup 0/(H/sub 2/O/H/sub 2/) is the same as E/sup 0/(MV/sup 2+/+/). A surface derivatizing reagent from diquarternizing 4,4'-bipyridine with 1-bromo-3-trimethyloxysilylpropane can be used to functionalize p-type Si with polymeric quantities of redox reagent. The surface-confined bipyridinium reagent, (PQ/sup 2 +/)/sub surf./, can be photoreduced to (PQ/sup +/)/sub surf./ and this reduced species can be used to effect H/sub 2/ evolution if a Pt catalyst is incorporated into the polymer. Efficiency for conversion of monochromatic 632.8 nm light to H/sub 2/ exceeds 6%, compared to much less than 1% for the naked p-type Si without the surface catalyst system. Studies of n-type semiconductor (photoanode) electrode materials modified with biferrocene-based redox mediators for I/sup -/ ..-->.. I/sub 3//sup -/ oxidation have been undertaken for comparison to ferrocene-based reagents for the same reaction; a five- to ten-fold overall improvement in heterogeneous I/sup -/ ..-->.. I/sub 3//sup -/ rate can be achieved using the two-electron mediator compared to the one-electron transfer system.

  13. Longitudinal follow-up study of smoking-induced emphysema progression in low-dose CT screening of lung cancer

    Science.gov (United States)

    Suzuki, H.; Matsuhiro, M.; Kawata, Y.; Niki, N.; Nakano, Y.; Ohmatsu, H.; Kusumoto, M.; Tsuchida, T.; Eguchi, K.; Kaneko, Masahiro; Moriyama, N.

    2014-03-01

    Chronic obstructive pulmonary disease is a major public health problem that is predicted to be third leading cause of death in 2030. Although spirometry is traditionally used to quantify emphysema progression, it is difficult to detect the loss of pulmonary function by emphysema in early stage, and to assess the susceptibility to smoking. This study presents quantification method of smoking-induced emphysema progression based on annual changes of low attenuation volume (LAV) by each lung lobe acquired from low-dose CT images in lung cancer screening. The method consists of three steps. First, lung lobes are segmented using extracted interlobar fissures by enhancement filter based on fourdimensional curvature. Second, LAV of each lung lobe is segmented. Finally, smoking-induced emphysema progression is assessed by statistical analysis of the annual changes represented by linear regression of LAV percentage in each lung lobe. This method was applied to 140 participants in lung cancer CT screening for six years. The results showed that LAV progressions of nonsmokers, past smokers, and current smokers are different in terms of pack-year and smoking cessation duration. This study demonstrates effectiveness in diagnosis and prognosis of early emphysema in lung cancer CT screening.

  14. Genetic study of autosomal dominant progressive external ophthalmoplegia and familial myasthenia gravis : linkage analysis, candidate gene cloning and mutation detection

    OpenAIRE

    Li, Fang-Yuan

    2001-01-01

    Identification of genes responsible for familial human diseases is a major task of medical genetics. In this process, linkage analysis, candidate gene screening and mutation detection are the three major steps (Paper I-VI). The purpose of this study was to elucidate the genetic backgrounds of autosomal dominant progressive external ophthalmoplegia (adPEO) and familial inyasthenia gravis (FMG). The methods applied in this study for linkage analysis and repeat expansion we...

  15. Processing of high level waste: Spectroscopic characterization of redox reactions in supercritical water. 1998 annual progress report

    International Nuclear Information System (INIS)

    'The author is engaged in a collaborative research effort with Los Alamos staff scientists Steven Buelow, Jeanne Robinson, and Bernie Foy all staff members in group CST-6. The work proposed by these LANL staff scientists is directed towards the destruction of complexants and oxidation of chromium and technetium by hydrothermal processing in near critical or supercritical aqueous solutions. The work addresses two areas of investigation related to ongoing efforts at LANL: (1) kinetic studies of oxidation-reduction reactions in supercritical water; (2) measurement of physical properties of ionic solutes in supercritical water. All of the work during this first year was carried out at Los Alamos National Lab. During the Summer program at LANL all equipment and supplies were provided through Dr. Buelow''s program at LANL. The author has now set up a Raman spectroscopy lab at Furman. Using departmental funds he purchased an optical bench, a laser, and a CCD detector, and a grant from the Dreyfus Foundation assisted in the purchase of a Raman spectrometer. He is now able to carry out experiments using the Raman system at Furman. The plan is to continue the Summer collaboration at LANL and carry out experiments at Furman during the academic year.'

  16. A characterization and evaluation of coal liquefaction process streams. Quarterly technical progress report, January 1, through March 31, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-01

    The objectives of this project are to support the DOE direct coal liquefaction process development program and to improve the useful application of analytical chemistry to direct coal liquefaction process development. Independent analyses by well-established methods will be obtained of samples produced in direct coal liquefaction processes under evaluation by DOE. Additionally, analytical instruments and techniques which are currently underutilized for the purpose of examining coal-derived samples will be evaluated. The data obtained from this study will be used to help guide current process development and to develop an improved data base on coal and coal liquids properties. A sample bank will be established and maintained for use in this project and will be available for use by other researchers. The reactivity of the non-distillable resids toward hydrocracking at liquefaction conditions (i.e., resid reactivity) will be examined. From the literature and data experimentally obtained, a mathematical kinetic model of resid conversion will be constructed. It is anticipated that such a model will provide insights useful for improving process performance and thus the economics of direct coal liquefaction. Accomplishments for this quarter are described.

  17. A characterization and evaluation of coal liquefaction process streams. Quarterly technical progress report, July 1--September 30, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Robbins, G.A.; Brandes, S.D.; Winschel, R.A.; Burke, F.P.

    1995-12-01

    The objectives of this project are to support the DOE direct coal liquefaction process development program and to improve the useful application of analytical chemistry to direct coal liquefaction process development. Independent analyses by well-established methods will be obtained of samples produced in direct coal liquefaction processes under evaluation by DOE. Additionally, analytical instruments and techniques which are currently underutilized for the purpose of examining coal-derived samples will be evaluated. The data obtained from this study will be used to help guide current process development and to develop an improved data base on coal and coal liquids properties. A sample bank will be established and maintained for use in this project and will be available for use by other researchers. The reactivity of the non-distillable resids toward hydrocracking at liquefaction conditions (i.e., resid reactivity) will be examined. From the literature and data experimentally obtained, a mathematical kinetic model of resid conversion will be constructed. It is anticipated that such a model will provide insights useful for improving process performance and thus the economics of direct coal liquefaction. Some of the contract activities for this quarter are: We completed many of the analyses on the 81 samples received from HTI bench-scale run CMSL-9, in which coal, coal/mixed plastics, and coal/high density polyethylene were fed; Liquid chromatographic separations of the 15 samples in the University of Delaware sample set were completed; and WRI completed CP/MAS {sup 13}C-NMR analyses on the Delaware sample set.

  18. Prospective noninterventional study on the use of panitumumab monotherapy in patients with recurrent or progressive colorectal cancer: the VECTIS study

    Directory of Open Access Journals (Sweden)

    Lakomy R

    2015-10-01

    Full Text Available Radek Lakomy,1,2 Wojciech Rogowski,3 Bela Piko,4 Zhasmina Mihaylova,5 Eva Pritzova,6 Lucia Kvocekova7 1Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic; 2Faculty of Medicine, Masaryk University, Brno, Czech Republic; 3Department of Chemotherapy, Warmia and Masuria Oncology Center, Olsztyn, Poland; 4Pándy Kálmán County Hospital, Gyula, Hungary; 5Department of Medical Oncology, Military Medical Academy, Sofia, Bulgaria; 6F.D. Roosevelt Teaching Hospital with Policlinic, Banska Bystrica, Slovak Republic; 7AMGEN s.r.o., Prague, Czech Republic Purpose: Epidermal growth factor receptor-targeted monoclonal antibodies are active as monotherapy beyond second-line treatment. Skin toxicities (STs are common during treatment, and a positive association between ST severity and patient outcome has been reported. This study collected information on panitumumab monotherapy use in patients with KRAS exon 2 wild-type metastatic colorectal cancer in clinical practice.Methods: This open-label, prospective, observational, noninterventional study included adult patients who had failed prior chemotherapy with 5-fluorouracil, oxaliplatin, and irinotecan. Patients received panitumumab monotherapy (6 mg/kg every 2 weeks for ≤18 cycles. Effectiveness was assessed as disease control rate (DCR, tumor response, and freedom from progression. The incidence of ST and other adverse drug reactions (ADRs was recorded, as were Eastern Cooperative Oncology Group performance status (ECOG PS and quality of life. The KRAS analysis process was also evaluated.Findings: The full analysis set included 632 patients (64.6% male; mean age, 62.3 years, who completed a mean of 9.6 panitumumab cycles. ST, mainly grade 1/2, occurred in 84.3% of patients, 82.7% of whom required treatment. Nonskin ADRs occurred in 3.5% of patients. By the end of treatment, the DCR was 58.9% overall, and was 53.8% and 62.7%, respectively in patients with ST grade

  19. Site characterization progress report: Yucca Mountain, Nevada, October 1, 1994--March 31, 1995, Number 12. Nuclear Waste Policy Act (Section 113)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-08-01

    During the first half of fiscal year 1995, most activities at the Yucca Mountain Site Characterization Project were directed at implementing the Program Plan developed by the Office of Civilian Radioactive Waste Management. The Plan is designed to enable the Office to make measurable and significant progress toward key objectives over the next five years within the financial resources that can be realistically expected. Activities this period focused on the immediate goal of determining by 1998 whether Yucca Mountain, Nevada, is technically suitable as a possible site for a geologic repository for the permanent disposal of spent nuclear fuel and high-level radioactive waste. Work on the Project advanced in several critical areas, including programmatic activities such as issuing the Program Plan, completing the first technical basis report to support the assessment of three 10 CFR 960 guidelines, developing the Notice of Intent for the Environmental Impact Statement, submitting the License Application Annotated Outline, and beginning a rebaselining effort to conform with the goals of the Program Plan. Scientific investigation and analysis of the site and design and construction activities to support the evaluation of the technical suitability of the site also advanced. Specific details relating to all Project activities and reports generated are presented in this report.

  20. Site characterization progress report: Yucca Mountain, Nevada, October 1, 1994--March 31, 1995, Number 12. Nuclear Waste Policy Act (Section 113)

    International Nuclear Information System (INIS)

    During the first half of fiscal year 1995, most activities at the Yucca Mountain Site Characterization Project were directed at implementing the Program Plan developed by the Office of Civilian Radioactive Waste Management. The Plan is designed to enable the Office to make measurable and significant progress toward key objectives over the next five years within the financial resources that can be realistically expected. Activities this period focused on the immediate goal of determining by 1998 whether Yucca Mountain, Nevada, is technically suitable as a possible site for a geologic repository for the permanent disposal of spent nuclear fuel and high-level radioactive waste. Work on the Project advanced in several critical areas, including programmatic activities such as issuing the Program Plan, completing the first technical basis report to support the assessment of three 10 CFR 960 guidelines, developing the Notice of Intent for the Environmental Impact Statement, submitting the License Application Annotated Outline, and beginning a rebaselining effort to conform with the goals of the Program Plan. Scientific investigation and analysis of the site and design and construction activities to support the evaluation of the technical suitability of the site also advanced. Specific details relating to all Project activities and reports generated are presented in this report

  1. Physicochemical characterization and solubility enhancement studies of allopurinol solid dispersions

    Directory of Open Access Journals (Sweden)

    Jagdale Swati Changdeo

    2011-09-01

    Full Text Available Allopurinol is a commonly used drug in the treatment of chronic gout or hyperuricaemia associated with treatment of diuretic conditions. One of the major problems with the drug is that it is practically insoluble in water, which results in poor bioavailability after oral administration. In the present study, solid dispersions of allopurinol were prepared by solvent evaporation, kneading method, co-precipitation method, co-grinding method and closed melting methods to increase its water solubility. Hydrophilic carriers such as polyvinylpyrrolidone, polyethylene glycol 6000 were used in the ratio of 1:1, 1:2 and 1:4 (drug to carrier ratio. The aqueous solubility of allopurinol was favored by the presence of both polymers. These new formulations were characterized in the liquid state by phase solubility studies and in the solid state by differential scanning calorimetry, powder X-ray diffraction, UV and Fourier Transform Infrared spectroscopy. Solid state characterizations indicated that allopurinol was present as an amorphous material and entrapped in polymer matrix. In contrast to the very slow dissolution rate of pure allopurinol, the dispersion of the drug in the polymers considerably enhanced the dissolution rate. Solid dispersion prepared with polyvinylpyrrolidone showed highest improvement in wettability and dissolution rate of allopurinol. Mathematical modeling of in vitro dissolution data indicated the best fitting with Korsemeyer-Peppas model and the drug release kinetics primarily as Non-Fickian diffusion. Therefore, the present study showed that polyvinylpyrrolidone and polyethylene glycol 6000 have a significant solubilizing effect on allopurinol.Alopurinol é fármaco comumente utilizado no tratamento de gota crônica ou hiperuricemia associada com o tratamento em condições diuréticas. Um dos maiores problemas com o fármaco é que este é praticamente insolúvel em água, o que resulta em baixa biodisponibilidade na administra

  2. Recurrent Major Depression Predicts Progression of Coronary Calcification in Healthy Women: Study of Women’s Health across the Nation

    Science.gov (United States)

    Matthews, Karen A.; Chang, Yue-Fang; Sutton-Tyrrell, Kim; Edmundowicz, Daniel; Bromberger, Joyce T.

    2010-01-01

    Background Depressive symptoms and major depression are risk factors for clinical coronary heart disease (CHD) among CHD patients and among healthy individuals. It is less clear whether depression is related to the progression of atherosclerosis prior to the onset of CHD events. Design Longitudinal cohort study Methods 149 middle-aged healthy women (113 white and 36 African American) who reported no heart disease, stroke, or diabetes were enrolled simultaneously in two ancillary studies of the Study Women’s Health across the Nation (SWAN) at the Pittsburgh site: the Mental Health Study and the SWAN Heart Study. These women were administered psychiatric interviews annually and coronary calcification computed tomography measures (CAC) on two occasions approximately 2¼ years apart. Results Women who had recurrent major depression (N = 33) had greater progression of CAC (logged difference scores) than did women with a single or no episodes, b = 0.09 (0.04), p = .01. The other significant covariates were BMI, SBP, initial CAC, and time between scans. Stratified analyses showed that the effect was obtained in those women who had any CAC at the first examination. Conclusions Recurrent major depression may be a risk factor for progression of atherosclerosis, especially in those who have at least some initial calcification. Women with a history of depression may be candidates for aggressive cardiovascular risk factor prevention therapy. PMID:20668281

  3. Pilot study of dynamic Bayesian networks approach for fault diagnostics and accident progression prediction in HTR-PM

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Yunfei; Tong, Jiejuan; Zhang, Liguo, E-mail: lgzhang@tsinghua.edu.cn; Zhang, Qin

    2015-09-15

    Highlights: • Dynamic Bayesian network is used to diagnose and predict accident progress in HTR-PM. • Dynamic Bayesian network model of HTR-PM is built based on detailed system analysis. • LOCA Simulations validate the above model even if part monitors are lost or false. - Abstract: The first high-temperature-reactor pebble-bed demonstration module (HTR-PM) is under construction currently in China. At the same time, development of a system that is used to support nuclear emergency response is in progress. The supporting system is expected to complete two tasks. The first one is diagnostics of the fault in the reactor based on abnormal sensor measurements obtained. The second one is prognostic of the accident progression based on sensor measurements obtained and operator actions. Both tasks will provide valuable guidance for emergency staff to take appropriate protective actions. Traditional method for the two tasks relies heavily on expert judgment, and has been proven to be inappropriate in some cases, such as Three Mile Island accident. To better perform the two tasks, dynamic Bayesian networks (DBN) is introduced in this paper and a pilot study based on the approach is carried out. DBN is advantageous in representing complex dynamic systems and taking full consideration of evidences obtained to perform diagnostics and prognostics. Pearl's loopy belief propagation (LBP) algorithm is recommended for diagnostics and prognostics in DBN. The DBN model of HTR-PM is created based on detailed system analysis and accident progression analysis. A small break loss of coolant accident (SBLOCA) is selected to illustrate the application of the DBN model of HTR-PM in fault diagnostics (FD) and accident progression prognostics (APP). Several advantages of DBN approach compared with other techniques are discussed. The pilot study lays the foundation for developing the nuclear emergency response supporting system (NERSS) for HTR-PM.

  4. Pilot study of dynamic Bayesian networks approach for fault diagnostics and accident progression prediction in HTR-PM

    International Nuclear Information System (INIS)

    Highlights: • Dynamic Bayesian network is used to diagnose and predict accident progress in HTR-PM. • Dynamic Bayesian network model of HTR-PM is built based on detailed system analysis. • LOCA Simulations validate the above model even if part monitors are lost or false. - Abstract: The first high-temperature-reactor pebble-bed demonstration module (HTR-PM) is under construction currently in China. At the same time, development of a system that is used to support nuclear emergency response is in progress. The supporting system is expected to complete two tasks. The first one is diagnostics of the fault in the reactor based on abnormal sensor measurements obtained. The second one is prognostic of the accident progression based on sensor measurements obtained and operator actions. Both tasks will provide valuable guidance for emergency staff to take appropriate protective actions. Traditional method for the two tasks relies heavily on expert judgment, and has been proven to be inappropriate in some cases, such as Three Mile Island accident. To better perform the two tasks, dynamic Bayesian networks (DBN) is introduced in this paper and a pilot study based on the approach is carried out. DBN is advantageous in representing complex dynamic systems and taking full consideration of evidences obtained to perform diagnostics and prognostics. Pearl's loopy belief propagation (LBP) algorithm is recommended for diagnostics and prognostics in DBN. The DBN model of HTR-PM is created based on detailed system analysis and accident progression analysis. A small break loss of coolant accident (SBLOCA) is selected to illustrate the application of the DBN model of HTR-PM in fault diagnostics (FD) and accident progression prognostics (APP). Several advantages of DBN approach compared with other techniques are discussed. The pilot study lays the foundation for developing the nuclear emergency response supporting system (NERSS) for HTR-PM

  5. Phase II study of radiopeptide {sup 177}Lu-octreotate and capecitabine therapy of progressive disseminated neuroendocrine tumours

    Energy Technology Data Exchange (ETDEWEB)

    Claringbold, Phillip G. [Fremantle Hospital, Department of Oncology, Fremantle, WA (Australia); Brayshaw, Paul A.; Turner, J.H. [University of Western Australia, Department of Nuclear Medicine, Fremantle Hospital, Fremantle, WA (Australia); Price, Richard A. [Fremantle Hospital, Department of Radiology, Fremantle, WA (Australia)

    2011-02-15

    In this phase II study we investigated the safety and efficacy of combination capecitabine and {sup 177}Lu-octreotate for the treatment of disseminated, progressive, unresectable neuroendocrine tumours (NETs). Enrolled in the study were 33 patients with biopsy-proven NETs, positive {sup 111}In-octreotide scintigraphy and progressive disease measurable by CT/MRI who were to receive four cycles of 7.8 GBq {sup 177}Lu-octreotate 8-weekly, with 14 days of 1,650 mg/m{sup 2} capecitabine per day. Of the 33 patients, 25 completed four cycles. Minimal transient myelosuppression at 3-4 weeks caused grade 3 thrombocytopenia in one patient but no neutropenia. Nephrotoxicity was absent. Critical organ radiation dosimetry provided median estimates of the dose per cycle to the kidneys of 2.4 Gy and to the liver of 4.8 Gy, and showed cumulative doses all below toxic thresholds. Objective response rates (ORR) were 24% partial response (PR), 70% stable disease (SD) and 6% progressive disease. Median progression-free survival and median overall survival had not been reached at a median follow-up of 16 months (range 5-33 months). Survival at 1 and 2 years was 91% (95% CI 75-98%) and 88% (95% CI 71-96%), respectively. The addition of capecitabine radiosensitizing chemotherapy does not increase the minimal toxicity of {sup 177}Lu-octreotate radiopeptide therapy and led to an ORR of 24% PR and 70% minor response or SD in patients with progressive metastatic NETs. Tumour control and stabilization of disease was obtained in 94% of these patients. (orig.)

  6. Progress and review of the studies on the end-Triassic mass extinction event

    Institute of Scientific and Technical Information of China (English)

    DENG; Shenghui; LU; Yuanzheng; XU; Daoyi

    2005-01-01

    The mass extinction at the end-Triassic is one of the five biggest in the Phanerozoic. However,it is the least well understood among these five events, and only till last decade it became a great academic interesting subject to geologists. The evidences for this event come obviously from bivalves, brachiopods, ammonites, corals, radiolaria, ostracods and foraminifera of marine habitats, and plants and tetrapods of terrestrial realm. By contrast, for some of other groups, such as marine gastropods and marine vertebrates, no mass extinction has been recognized yet. The extinction event is strongly marked at specific level but shown a complicated situation at generic and family levels. Dramatic changing of the environment, such as the temperature raise due to the greenhouse effect, the marine anoxic habitats caused by a sudden transgression after the regression at the end of Triassic, has been claimed to be the main cause of the extinction. Many hypotheses have been suggested to demonstrate the mechanisms of the environment changing, among which two popular ones are the bolide impact and volcanic eruption. The Triassic-Jurassic (Tr-J) boundary mass extinction event is still poorly understood because no enough data have been obtained from the Tr-J boundary successional sections of both marine and terrestrial sediments, and most of these studies were regionally restricted. The basic aspects of the event and its associated environmental conditions remain poorly characterized and the causal mechanism or mechanisms are equivocal. Some authors even doubt its occurrence. China has many successionally developed terrestrial and marine Tr-J sections. Detailed studies of these sections may be important and significant for well understanding of the event.

  7. Sirolimus for progressive neurofibromatosis type 1–associated plexiform neurofibromas: a Neurofibromatosis Clinical Trials Consortium phase II study

    Science.gov (United States)

    Weiss, Brian; Widemann, Brigitte C.; Wolters, Pamela; Dombi, Eva; Vinks, Alexander; Cantor, Alan; Perentesis, John; Schorry, Elizabeth; Ullrich, Nicole; Gutmann, David H.; Tonsgard, James; Viskochil, David; Korf, Bruce; Packer, Roger J.; Fisher, Michael J.

    2015-01-01

    Background Plexiform neurofibromas (PNs) are benign peripheral nerve sheath tumors that arise in one-third of individuals with neurofibromatosis type 1 (NF1). They may cause significant disfigurement, compression of vital structures, neurologic dysfunction, and/or pain. Currently, the only effective management strategy is surgical resection. Converging evidence has demonstrated that the NF1 tumor suppressor protein, neurofibromin, negatively regulates activity in the mammalian Target of Rapamycin pathway. Methods We employed a 2-strata clinical trial design. Stratum 1 included subjects with inoperable, NF1-associated progressive PN and sought to determine whether sirolimus safely and tolerably increases time to progression (TTP). Volumetric MRI analysis conducted at regular intervals was used to determine TTP relative to baseline imaging. Results The estimated median TTP of subjects receiving sirolimus was 15.4 months (95% CI: 14.3–23.7 mo), which was significantly longer than 11.9 months (P < .001), the median TTP of the placebo arm of a previous PN clinical trial with similar eligibility criteria. Conclusions This study demonstrated that sirolimus prolongs TTP by almost 4 months in patients with NF1-associated progressive PN. Although the improvement in TTP is modest, given the lack of significant or frequent toxicity and the availability of few other treatment options, the use of sirolimus to slow the growth of progressive PN could be considered in select patients. PMID:25314964

  8. Effect of Cellular Therapy in Progression of Becker's Muscular Dystrophy: A Case Study.

    Science.gov (United States)

    Sharma, Alok; Sane, Hemangi; Gokulchandra, Nandini; Sharan, Rishabh; Paranjape, Amruta; Kulkarni, Pooja; Yadav, Jayanti; Badhe, Prerna

    2016-02-23

    Becker muscular dystrophy (BMD) is an inherited disorder due to deletions of the dystrophin gene that leads to muscle weakness. Effects of bone marrow mononuclear cell (BMMNC) transplantation in Muscular Dystrophy have shown to be safe and beneficial. We treated a 20-year-old male suffering from BMD with autologous BMMNC transplantation followed by multidisciplinary rehabilitation. He presented with muscle weakness and had difficulty in performing his activities. The BMMNCs were transplanted via intrathecal and intramuscular routes. The effects were measured on clinical and functional changes. Over 9 months, gradual improvement was noticed in muscle strength, respiratory functions and North Star Ambulatory Assessment Scale. Functional Independence Measure, Berg Balance Score, Brooke and Vignos Scale remained stable indicating halting of the progression. The case report suggests that cellular therapy combined with rehabilitation may have possibility of repairing and regenerating muscle fibers and decreasing the rate of progression of BMD. PMID:27054018

  9. Effect of cellular therapy in progression of Becker’s muscular dystrophy: a case study

    Directory of Open Access Journals (Sweden)

    Alok Sharma

    2016-03-01

    Full Text Available Becker muscular dystrophy (BMD is an inherited disorder due to deletions of the dystrophin gene that leads to muscle weakness. Effects of bone marrow mononuclear cell (BMMNC transplantation in Muscular Dystrophy have shown to be safe and beneficial. We treated a 20-year-old male suffering from BMD with autologous BMMNC transplantation followed by multidisciplinary rehabilitation. He presented with muscle weakness and had difficulty in performing his activities. The BMMNCs were transplanted via intrathecal and intramuscular routes. The effects were measured on clinical and functional changes. Over 9 months, gradual improvement was noticed in muscle strength, respiratory functions and North Star Ambulatory Assessment Scale. Functional Independence Measure, Berg Balance Score, Brooke and Vignos Scale remained stable indicating halting of the progression. The case report suggests that cellular therapy combined with rehabilitation may have possibility of repairing and regenerating muscle fibers and decreasing the rate of progression of BMD.

  10. Progress in welding studies for Canadian nuclear fuel waste disposal containers

    International Nuclear Information System (INIS)

    This report describes the progress in the development of closure-welding technology for Canadian nuclear fuel waste disposal containers. Titanium, copper and Inconel 625 are being investigated as candidate materials for fabrication of these containers. Gas-tungsten-arc welding, gas metal-arc-welding, resistance-heated diffusion bonding and electron beam welding have been evaluated as candidate closure welding processes. Characteristic weldment properties, relative merits of welding techniques, suitable weld joint configurations and fit-up tolerances, and welding parameter control ranges have been identified for various container designs. Furthermore, the automation requirements for candidate welding processes have been assessed. Progress in the development of a computer-controlled remote gas-shielded arc welding system is described

  11. Dosimetric characterization of two radium sources for retrospective dosimetry studies

    Energy Technology Data Exchange (ETDEWEB)

    Candela-Juan, C., E-mail: ccanjuan@gmail.com [Radiation Oncology Department, La Fe University and Polytechnic Hospital, Valencia 46026, Spain and Department of Atomic, Molecular and Nuclear Physics, University of Valencia, Burjassot 46100 (Spain); Karlsson, M. [Division of Radiological Sciences, Department of Medical and Health Sciences, Linköping University, Linköping SE 581 85 (Sweden); Lundell, M. [Department of Medical Physics and Oncology, Karolinska University Hospital and Karolinska Institute, Stockholm SE 171 76 (Sweden); Ballester, F. [Department of Atomic, Molecular and Nuclear Physics, University of Valencia, Burjassot 46100 (Spain); Tedgren, Å. Carlsson [Division of Radiological Sciences, Department of Medical and Health Sciences, Linköping University, Linköping SE 581 85, Sweden and Swedish Radiation Safety Authority, Stockholm SE 171 16 (Sweden)

    2015-05-15

    Purpose: During the first part of the 20th century, {sup 226}Ra was the most used radionuclide for brachytherapy. Retrospective accurate dosimetry, coupled with patient follow up, is important for advancing knowledge on long-term radiation effects. The purpose of this work was to dosimetrically characterize two {sup 226}Ra sources, commonly used in Sweden during the first half of the 20th century, for retrospective dose–effect studies. Methods: An 8 mg {sup 226}Ra tube and a 10 mg {sup 226}Ra needle, used at Radiumhemmet (Karolinska University Hospital, Stockholm, Sweden), from 1925 to the 1960s, were modeled in two independent Monte Carlo (MC) radiation transport codes: GEANT4 and MCNP5. Absorbed dose and collision kerma around the two sources were obtained, from which the TG-43 parameters were derived for the secular equilibrium state. Furthermore, results from this dosimetric formalism were compared with results from a MC simulation with a superficial mould constituted by five needles inside a glass casing, placed over a water phantom, trying to mimic a typical clinical setup. Calculated absorbed doses using the TG-43 formalism were also compared with previously reported measurements and calculations based on the Sievert integral. Finally, the dose rate at large distances from a {sup 226}Ra point-like-source placed in the center of 1 m radius water sphere was calculated with GEANT4. Results: TG-43 parameters [including g{sub L}(r), F(r, θ), Λ, and s{sub K}] have been uploaded in spreadsheets as additional material, and the fitting parameters of a mathematical curve that provides the dose rate between 10 and 60 cm from the source have been provided. Results from TG-43 formalism are consistent within the treatment volume with those of a MC simulation of a typical clinical scenario. Comparisons with reported measurements made with thermoluminescent dosimeters show differences up to 13% along the transverse axis of the radium needle. It has been estimated that

  12. Studies of e+e- interactions. Progress report, August 1, 1984-July 31, 1985

    International Nuclear Information System (INIS)

    Progress is reported in the development of the AMY electromagnetic shower counter. The design of the detector has been finalized. Fabrication of components was begun. Techniques have been developed to construct the detector with precision and reliability. Activities have been conducted to assess the expected performance of the completed detector. Appended are notes on the adhesive strength of epoxy for tensile stress and on the effects of distance between cathodes and plastic tubes on cathode signals

  13. Reaction studies of hot silicon and germanium radicals. Progress report, September 1, 1978-August 31, 1979

    International Nuclear Information System (INIS)

    The experimental approach to attaining the goals of this research program is briefly outlined and the progress made in the last year is reviewed in sections entitled: (a) Primary steps in the reaction of recoiling silicon and germanium atoms and the identification of reactive intermediates; (b) Thermally induced silylene and germylene reactions; (c) Silicon free radical chemistry; (d) The role of ionic reactions in the chemistry of recoiling silicon atoms

  14. Bubble chamber studies of hadron and photon interactions. Progress report, April 1, 1983-March 31, 1984

    International Nuclear Information System (INIS)

    Progress is briefly reported on a number of experiments on hadron and photon interactions. Stand-alone bubble chamber experiments were completed, and current efforts focus on hybrid chamber research. Two new projects are being proposed-mu neutrinos in the Kitigaki bubble chamber at Fermilab, and a search for a threshold enhancement in the production of sigma particles in the SLAC 40 hybrid chamber. Photoproduction and antinucleon physics are covered. Experiments at CERN were run to observe diffractive strange particle production

  15. Progressive pulmonary paracoccidioidomycosis. A study of 34 cases observed in Rio Grande do Sul (Brazil)

    International Nuclear Information System (INIS)

    Data on 34 patients with progressive pulmonary paracoccidioidomycosis seen in the State of Rio Grande do Sul (Brazil) are reviewed. Clinical manifestations were similar to those of a prolonged or a recurrent undifferentiated respiratory infection. Roentgenographic findings were also non-characteristic, although generalized x-ray lesions were verified in 19 patients. Microscopic investigation of the sputum resolved the uncertainties about the diagnosis. (Auth.)

  16. Progress on laboratory studies of the immobilisation of plutonium contaminated materials (pcm)

    International Nuclear Information System (INIS)

    This report describes progress on laboratory scale investigations into immobilisation of Plutonium Contaminated Materials for the year ending August 1984. The work is a continuation of that previously reported though some new work is also included. The samples tested were shredded plastic materials and latex. Three areas of work are covered (1) ISO Leach Tests (2) Radiolysis and degradation of organic materials (3) Equilibrium Leach Tests. (author)

  17. A study on intelligent nuclear systems. HASP : human acts simulation program. Progress report 1993

    International Nuclear Information System (INIS)

    The seventh year progress of the Human Acts Simulation Program, HASP in short, has been presented in this report. The HASP started in 1987 at JAERI as ten-year research and development program of underlying technologies for intelligent robots, intelligent nuclear plants and so on. It consists of the research and development of technologies of knowledge-base, robot vision, robot kinematics/kinetics, plant geometry data-base, dose evaluation and Monte Carlo machine. (author)

  18. Theoretical studies in hadronic and nuclear physics. Progress report, July 1, 1994--June 1, 1995

    International Nuclear Information System (INIS)

    This progress report contains 36 items of research work done by ten members of the University of Maryland Nuclear Theory Group with 21 outside collaborators from various institutions in the US, Canada, Korea and Europe. The report is in four sections, each representing major and basic areas of interest in nuclear theory. The sections are as follows: (1) hadrons in nuclei and nuclear matter; (2) hadron physics; (3) relativistic dynamics in quark, hadron and nuclear physics; (4) heavy ion dynamics and related processes

  19. The progress of functional neuroimaging in the study of mild cognitive impairment

    International Nuclear Information System (INIS)

    Mild cognitive impairment (MCI) represents a transitional state between healthy aging and very mild Alzheimer's disease. MCI patients have a substantially higher rate of progression to Alzheimer's disease compared with cognitively normal elderly people. Functional neutroimaging modalities, including PET, SPECT and functional MRI show that MCI patients have special abnormalities in brain metabolism and perfusion, so they can offer great value in the predicting cognitive decline and early diagnosis of dementia. (authors)

  20. PET studies of brain energy metabolism in a model of subcortical dementia: progressive supranuclear Palsy

    International Nuclear Information System (INIS)

    In 41 patients with clinically determined Progressive Supranuclear Palsy, a model of degenerative subcortical dementia, alterations in regional brain energy metabolism with respect to control subjects have been investigated using positron computed tomography and correlated to clinical and neuropsychological scores. A generalized significant reduction in brain metabolism was found, which predominated in the prefrontal cortex in accordance with, and statistically correlated to, the frontal neuropsychological score

  1. Synthesis, characterization and in vitro studies of pegylated melphalan conjugates.

    Science.gov (United States)

    Ajazuddin; Alexander, Amit; Amarji, Basant; Kanaujia, Parijat

    2013-07-01

    Melphalan, a drug used for the treatment of breast, ovaries and a certain type of cancer in the bone marrow, was conjugated to linear methoxy poly (ethylene glycol) (M-PEG) of 2000 and 5000, Da. An ester linkage between polymer and drug was used in the coupling to yield a polymeric prodrug. Purified esters were characterized by Maldi-Tof and IR spectroscopy methods. The modification allowed overcoming the known melphalan aqueous solubility problem (0.1 µg/ml) leading us to obtain a polymer-drug bioconjugate more suitable for oral and parental administration. It was found that molecular weight of M-PEG is critical for the conjugates stability, aqueous solubility (80 times and 123 times higher aqueous solubility for M-PEG 2000 and M-PEG 5000, respectively), and hemolytic activity. The melphalan caused 100% hemolysis above the concentration 3.5 µg/ml in 1 h. whereas conjugate of M-PEG 2000 and M-PEG 5000 shows 81.3 ± 0.5% and 48.8 ± 1.5% hemolysis, respectively at 32 µg/ml after1 h. Further In vitro anticancer activity of melphalan and its conjugates was performed with breast cancer MCF-7 cell lines. It shows that LD50 concentration was higher 1.14 and 2 µm for M-PEG 2000 and M-PEG 5000, respectively in comparison to pure melphalan (0.74 µm). Above studies revealed improved pharmacokinetics properties upon conjugation. PMID:22779444

  2. The non-obese diabetic mouse strain as a model to study CD8+ T cell function in relapsing and progressive multiple sclerosis.

    Directory of Open Access Journals (Sweden)

    Prenitha Mercy eIgnatius Arokia Doss

    2015-10-01

    Full Text Available Multiple sclerosis (MS is a neurodegenerative disease resulting from an autoimmune attack on central nervous system myelin. While CD4+ T cell function in MS pathology has been extensively studied, there is also strong evidence that CD8+ T lymphocytes play a key role. Intriguingly, CD8+ T cells accumulate in great numbers in the CNS in progressive MS, a form of the disease that is refractory to current disease-modifying therapies which target the CD4+ T cell response. Here, we discuss the function of CD8+ T cells in experimental autoimmune encephalomyelitis (EAE, a mouse model of MS. In particular, we describe EAE in non-obese diabetic (NOD background mice, which develop a pattern of disease characterized by multiple attacks and remissions followed by a progressively worsening phase. This is highly reminiscent of the pattern of disease observed in nearly half of MS patients. Particular attention is paid to a newly described transgenic mouse strain (1C6 on the NOD background whose CD4+ and CD8+ T cells are directed against the encephalitogenic peptide MOG[35-55]. Use of this model will give us a more complete picture of the role(s played by distinct T cell subsets in CNS autoimmunity.

  3. ZERODUR: progress in CTE characterization

    Science.gov (United States)

    Jedamzik, Ralf; Kunisch, Clemens; Westerhoff, Thomas

    2013-09-01

    In 2010, SCHOTT introduced a method for the modeling of the thermal expansion behavior of ZERODUR® under arbitrary temperature profiles for an optimized production of material for the upcoming Extremely Large Telescope (ELT) projects. In 2012 a new product was introduced based on this method called ZERODUR® TAILORED. ZERODUR® TAILORED provides an evolution in the specification of the absolute Coefficient of Thermal Expansion (CTE) value by including the individual customer requirements in this process. This paper presents examples showing the benefit of an application oriented approach in the design of specifications using ZERODUR®. Additionally it will be shown how the modeling approach has advanced during the last years to improve the prediction accuracy on long time scales. ZERODUR® is known not only for its lowest CTE but also for its excellent CTE homogeneity as shown in the past for disc shaped blanks typical for telescope mirror substrates. Additionally this paper presents recent results of CTE homogeneity measurements in the single digit ppb/K range for a rectangular cast plate proving that the excellent CTE homogeneity is independent of the production format.

  4. Chemical activation of molecules by metals: Experimental studies of electron distributions and bonding. Technical progress report, March 1, 1992--February 28, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Lichtenberger, D.L.

    1997-06-01

    During this period of the project we have (1) accomplished the high-resolution gas phase photoelectron spectra of C{sub 60} and C{sub 70}, (2) characterized the electronic features of imaging C{sub 60} on gold by STM, (3) evaluated the orbital distributions of C{sub 60} and the bonding interactions with metals, (4) revealed details of the bonding of phosphines to metals, including the subtleties of a geometrical twist in sterically crowded situations, (5) determined the formal electron distribution in the bonding of {eta}{sup 3} -cyclopropenyl with metals, (6) related gas-phase ionization energies to electron transfer kinetics and ion salvation thermochemistry of metallocenes, (7) correlated lone-pair ionization energies with proton affinities for a variety of amino acids and related compounds, (8) examined sigma-pi interactions in non-conjugated polyalkynes, (9) characterized extensive metal-ligand {pi} interactions in metal-acetylide compounds, and (10) continued to develop the experimental and theoretical methods for these studies. All of these studies have contributed significantly to expanding our understanding of the electronic structure and bonding of organic molecules and the ways this electronic structure is altered by interaction with metals. Further developments in the instrumentation and methods of gas phase and surface photoelectron spectroscopy are underway. Most notable is the progress on the new gas phase photoelectron spectrometer that combines improved capabilities for He I/He II UPS, XPS, and Auger investigations of organometallic molecules.

  5. Micromechanical study of corrosion products layers. Part I: Experimental characterization

    International Nuclear Information System (INIS)

    Highlights: ► The mechanical characterization of oxide formed on ancient ferrous artefacts has been performed. ► The main phases present are goethite, magnetite and maghemite. ► Typical ranges of the local mechanical properties can be related with the main phases present. ► The Young moduli at the micrometric scale vary between 50 and 200 GPa. ► Time dependent effects are negligible. - Abstract: A micromechanical characterization had been performed on ancient artefacts corrosion products. The proposed experimental approach allies scanning electron microscopy observations, micro-indentation tests which allow the characterization of the local stiffness of elementary constituents, and finally Raman micro-spectroscopy tests which give access to the local crystallised phases of the samples. The experimental campaign contains a large series of tests, which give us the opportunity to interpret the dispersion of local stiffness measurements.

  6. Micromechanical study of corrosion products layers. Part I: Experimental characterization

    Energy Technology Data Exchange (ETDEWEB)

    Dehoux, A., E-mail: dehoux@lmt.ens-cachan.fr [UPMC Univ., Paris 06, LMT-Cachan (ENS Cachan/UMR8535/UPMC) (France); Andra, Agence Nationale pour la gestion des Dechets RadioActifs, 1-7 rue Jean Monnet, parc de la croix blanche, 92298 Chatenay Malabry Cedex (France); Bouchelaghem, F.; Berthaud, Y. [UPMC Univ., Paris 06, LMT-Cachan (ENS Cachan/UMR8535/UPMC) (France); Neff, D. [SIS2M/LAPA-Laboratoire Pierre Suee, UMR 9956 CNRS, CEA, Bt. 637, CEA Saclay, 91191 Gif/Yvette (France); L' Hostis, V. [DEN, DANS, DPC, SCCME, Laboratoire d' Etude du Comportement des Betons et des Argiles, F-91191 Gif/Yvette (France)

    2012-01-15

    Highlights: Black-Right-Pointing-Pointer The mechanical characterization of oxide formed on ancient ferrous artefacts has been performed. Black-Right-Pointing-Pointer The main phases present are goethite, magnetite and maghemite. Black-Right-Pointing-Pointer Typical ranges of the local mechanical properties can be related with the main phases present. Black-Right-Pointing-Pointer The Young moduli at the micrometric scale vary between 50 and 200 GPa. Black-Right-Pointing-Pointer Time dependent effects are negligible. - Abstract: A micromechanical characterization had been performed on ancient artefacts corrosion products. The proposed experimental approach allies scanning electron microscopy observations, micro-indentation tests which allow the characterization of the local stiffness of elementary constituents, and finally Raman micro-spectroscopy tests which give access to the local crystallised phases of the samples. The experimental campaign contains a large series of tests, which give us the opportunity to interpret the dispersion of local stiffness measurements.

  7. Progress in Studies and Utilizations of Ceratoides%驼绒藜属植物研究

    Institute of Scientific and Technical Information of China (English)

    阿拉塔; 孙海莲

    2012-01-01

    Ceratoides is a super xerophytic semi-shrub with high feeding value and important ecological function. On reviewing the research progress,classification,distribution, ecological values of Ceratoides on the basis of previous studies,we focus on several aspects such as short-lived seeds, difficulties in direct sowing and underutilization of production. First, the Illumina HiSeq 2000 was used to sequence 20 G bases of the transeriptome for Ceratoides. The genomic information was expected for further study of the seed longevity in natural populations. Second, by using technique of seedling in small area and transplanting in big area, we apply it in Ceratoides production. Third ,we utilize and extend the cuhivar of Ceratoides in arid region, saline lands and mining district.Ceratoides for ecological restoration. Besides, to assess nutrition values ,we carry out the research on Ceratoides pellet feed preparation as an alternative of alfalfa in sheep feeding trial.%驼绒藜属植物是饲用价值较高的超旱生半灌木,有重要的生态利用价值。在查阅国内外对驼绒藜属植物研究利用的相关文献基础上,对该属植物的研究进展、分类、分布、生态作用等进行了分析和论述。针对生产中提出的种子短寿命、直播困难、生产利用缺乏等问题,介绍了内蒙古农牧业科学院驼绒藜课题组的具体科研思路和科研进展。一是针对种子短命问题。开展了驼绒藜转录组的分析和控制基因的定位研究,目前已获得20G的数据和完整的驼绒藜叶片组织的转录组集合,测序结果与信息将用于后续的种子寿命相关技术研发,期待实现能够延长种子寿命的产品或新材料;二是在种子直播技术未得到解决的情况下.采用小面积育苗后大面积移栽方式,将广泛应用于林业苗木生产的小面积育苗技术应用于驼绒藜属植物;三是针对生态应用技术,把自主知识产权的驼绒藜

  8. Synthesis and characterization studies of MgO:CuO nanocrystals by wet-chemical method

    Science.gov (United States)

    Kaviyarasu, K.; Maria Magdalane, C.; Anand, K.; Manikandan, E.; Maaza, M.

    2015-05-01

    In this report, we examine the progress in adapting these nanomaterials for several predominantly photonics device fabrication by wet-chemical method. Nanocomposite of magnesium oxide (MgO) with copper oxide (CuO) doped nanoparticles were characterized by X-ray powder diffraction (XRD) and the observed peaks are quite agreeable with the pure phase cubic structure. High-resolution transmission electron microscopic (HR-TEM) results reveal that the resultant nanopowders are porous and agglomerated with polycrystalline nano-entities. Field emission of selected-area electron diffraction (SAED) studies showed that the average size of the nanoparticles were 20 nm. Photoluminescence spectra of MgO:CuO were investigated, showing emission peaks around 375 nm relating to new energy levels induced by defects or defect levels generation and confocal micro-Raman images indicated that the chemical molecular vibrational band structure and morphology of the product which is spherical shaped nanoparticles with an average particle size of ∼25 nm with standard deviation. The electrochemical response of MgO:CuO which is proves that the nano-copper/magnesium has high functionality due to the small size and it has higher electrochemical activity without any modifications.

  9. Meeting information needs of patients with incurable progressive disease and their families in South Africa and Uganda: multicentre qualitative study

    OpenAIRE

    Selman, Lucy; Higginson, Irene J; Agupio, Godfrey; Dinat, Natalya; Downing, Julia; Gwyther, Liz; Mashao, Thandi; Mmoledi, Keletso; Moll, Anthony P.; Sebuyira, Lydia Mpanga; Panajatovic, Barbara; Harding, Richard

    2009-01-01

    Objectives To explore the information needs of patients with progressive, life limiting disease and their family caregivers in South Africa and Uganda and to inform clinical practice and policy in this emerging field. Design Semistructured qualitative interview study. Setting Four palliative care services in South Africa and one in Uganda, covering rural, urban, and peri-urban locations. Participants 90 patients and 38 family caregivers enrolled in palliative care services; 28 patients had ca...

  10. Studies on coumestrol/beta-cyclodextrin association: Inclusion complex characterization.

    Science.gov (United States)

    Franco, Camila; Schwingel, Liege; Lula, Ivana; Sinisterra, Rubén D; Koester, Letícia Scherer; Bassani, Valquiria Linck

    2009-03-18

    Coumestrol is an estrogenic and antioxidant agent, characterized by its low solubility in aqueous and lipophilic media, once in the aglicone form. In order to improve its solubility in water, coumestrol was associated with beta-cyclodextrin in aqueous media followed by freeze-drying and characterized by SEM, (1)H NMR and molecular modeling. The analysis proved the existence of an inclusion complex, with higher probability of inclusion of the coumestrol B-ring into the wider rim of the beta-cyclodextrin molecule. PMID:19028558

  11. Microelectronics materials characterization studies at the Cornell TRIGA Reactor

    International Nuclear Information System (INIS)

    The Cornell program of microelectronics materials characterization by neutron activation analysis (NAA) is described. Experimental details and results from the successful application of NAA to silicon germanium circuit structures and nickel silicide layers are presented. In doing so, the potential for using X rays from isotopes that decay by electron capture is demonstrated. (author)

  12. The esophageal transit in normal persons and in carrier of Chagas disease and progressive systemic sclerosis. A scintiscanning study

    International Nuclear Information System (INIS)

    The aim of this study is determine, by a scintiscanning method, how 10 ml of water, swallowed at one time, transit by the esophagus of normal persons and carriers of diseases, that attacking the esophagus motility. The other aim was determine the characteristics of the transit by the esophagus in carriers of chagasic esophagus diseases and of progressive systemic sclerosis. The study of esophageal transit was made by the technetium 99, with a gamma camera for detecting and quantifying the radioactivity. Several images of the esophageal transit, with persons in supine and seat positions, for processing the radioactivity curves x time are studied and compared. (C.G.C.)

  13. Theoretical reversed field pinch studies: Progress report, August 31, 1987 to June 1988

    International Nuclear Information System (INIS)

    This paper describes the progress made in Grant DE-FG02-85ER53212 since the end of the last year, August 31, 1987 to the present (June, 1988). Substantial results have emerged in two areas of high importance to the RFP program - nonlinear evolution with nonideal boundaries and self-consistent equilibrium in the presence of field errors. Both of these topics are critical for a basic understanding of RFP physics, for interpretation of current experiments, and for design of future devices and reactors. 3 refs

  14. [Progress in the studies of semen delayed liquefaction from chronic prostatitis].

    Science.gov (United States)

    Zhang, Yi-fei; Liang, Chao-zhao

    2007-01-01

    Chronic prostatitis (CP) is a common disease among adult men. It can result in male infertility mainly by alternating the semen quality, volume, pH, component, viscosity and liquefaction. There seems to be a strong association between CP and semen delayed liquefaction. Researches on the mechanism of semen delayed liquefaction resulting from CP mainly focus on the proteolytic ferment, plasminogen activator, prostate acid phosphatase, tissue factor, lack of zinc, and pH. This article briefly reviews the progress in these aspects. PMID:17302037

  15. Study progress of cardiac MRI technology in assessment of myocardial viability after myocardial infarction

    International Nuclear Information System (INIS)

    Acute myocardial infarction (AMI) is one of the most common diseases that cause disability and death around the world. Correctly and effectively assessing the myocardial viability after myocardial infarction can reduce the disabled rate and mortality rate. At present, many methods could be used to assess myocardial viability. The cardiac magnetic resonance imaging (CMR) technology has a lot of advantages compared to other methods. In this paper, we reviewed the research progress of CMR in assessment of myocardial viability after myocardial infarction, and compared CMR with other technologies. (authors)

  16. Theoretical studies of phenomenological models of nuclear chromodynamics: Progress report, January 1, 1988-December 31, 1988

    International Nuclear Information System (INIS)

    During the first year of our renewed research program significant progress has been made on the following research problems: in computing both elastic and inelastic pion-nucleon scattering phase shifts in the (1,1) and (3,3) channels within our pionic nontopological soliton model; in developing a new method for computing quantum soliton states and energies for all momenta in relativistic quantum field theory; and in applying the subsidiary condition theorem to soliton quantization in relativistic quantum field theory. These topics are discussed in this paper

  17. Salvage therapy of progressive and recurrent Hodgkin's disease: results from a multicenter study of the pediatric DAL/GPOH-HD study group.

    NARCIS (Netherlands)

    Schellong, G.; Dorffel, W.; Claviez, A.; Korholz, D.; Mann, G.; Scheel-Walter, H.G.; Bökkerink, J.P.M.; Riepenhausen, M.; Luders, H.; Potter, R.; Ruhl, U.

    2005-01-01

    PURPOSE: To evaluate a salvage therapy (ST-HD-86) for patients with progressive and relapsed Hodgkin's disease after primary treatment in the pediatric DAL/GPOH studies. The essential chemotherapeutic regimens were ifosfamide, etoposide, and prednisone (IEP) and doxorubicin, bleomycin, vinblastine,

  18. Nuclear structure studies by the scattering of medium-energy electrons. Progress report, October 1, 1980-July 31, 1981

    International Nuclear Information System (INIS)

    Electron scattering experiments are in progress at the Bates Linear Accelerator in Middleton, Massachusetts. Both magnetic elastic and transverse inelastic scattering cross sections have been measured at 1800 by the apparatus constructed and brought into operation in late 1977 by the University of Massachusetts. A liquid-nitrogen-cooled gas target is being used in a study of deuteron elastic magnetic scattering and electrodisintegration over a large energy range. A measurement of elastic magnetic and transverse inelastic scattering from 14N has been started. Measurements of the elastic magnetic scattering from 13C, 15N, 27Al, 29Si, and 31P have been completed. The data set on 15N inelastic scattering are now complete and analysis of the data is in progress. A study of M8 transitions in 54Fe and 60Ni is nearing completion. Several papers are being written on these subjects. A measurement of the transverse quasi-elastic scattering from 56Fe has been started. Planning for an experiment utilizing radioactive 14C is underway. Large-basis shell model calculations pertaining to the above nuclei and others have been made. Theoretical calculations of exchange currents, nuclear convection currents, and other nuclear phenomena are in progress. Finally, considerations are being given to the design of an integrated storage-ring-experimental system

  19. GT-MHR COMMERCIALZATION STUDY. TECHNICAL PROGRESS AND COST MANAGEMENT REPORT FOR THE PERIOD MAY 1 THROUGH MAY 31, 2003

    International Nuclear Information System (INIS)

    A271 GT-MHR COMMERCIALZATION STUDY TECHNICAL PROGRESS AND COST MANAGEMENT REPORT FOR THE PERIOD MAY 1 THROUGH MAY 31, 2003. Petten advised GA the start of the HFR-EU2 irradiation is being delayed until late July 2004. HFR-EU1 (pebble fuel) is also delayed until February/March 2004. The reason for the delays was implementation of new financial regulations at Petten that delayed the contracts for capsule fabrication. Review of the MHR-2 Fuel Product Specification was completed. Revision of the specification to incorporate the review results is in progress. Detailed test matrices have been drafted for capsule irradiation tests and for post-irradiation heating tests proposed for development and qualification of advanced coated-particle fuels capable of meeting anticipated VHTR fuel performance requirements

  20. Progress of a new instrument to study molecular dynamics of interstellar ion-neutral reactions

    Science.gov (United States)

    Perera, Manori; Roenitz, Kevin; Lamm, Ben; Rudd, Lydia; Justl, Andrew; Landeweer, Steven; Roadman, Danny; Koscielniak, Justyna; Sonnenberger, Andrew

    2016-06-01

    Astrochemistry, a relatively young field of research, addresses a gap in our understanding of molecular evolution in space. With many space missions gathering data, the number of unresolved spectral lines is growing rapidly. Each year there are about three new molecules that are identified in the interstellar medium (ISM). However, our understanding of molecular processes, branching ratios, and rates are at a beginner level. For instance, we do not yet understand the chemical processes associated with the creation and evolution of even the most basic prebiotic molecules such as water and methanol in space. One of the important steps toward understanding the chemistry of the ISM is to identify, through laboratory and theoretical work, a list of potential target molecules that are likely to exist in the ISM. This work describes experimental progress towards building a spectrometer that is able to produce complex cold ions that will react with cooled neutral molecules under conditions similar to those in space. I plan to present the instrumental progress and how astronomical reaction dynamic needs will be met using the instrument, and the present status of the instrument and measurements in my lab.

  1. Progression of brain atrophy in spinocerebellar ataxia type 2: a longitudinal tensor-based morphometry study.

    Directory of Open Access Journals (Sweden)

    Mario Mascalchi

    Full Text Available Spinocerebellar ataxia type 2 (SCA2 is the second most frequent autosomal dominant inherited ataxia worldwide. We investigated the capability of magnetic resonance imaging (MRI to track in vivo progression of brain atrophy in SCA2 by examining twice 10 SCA2 patients (mean interval 3.6 years and 16 age- and gender-matched healthy controls (mean interval 3.3 years on the same 1.5 T MRI scanner. We used T1-weighted images and tensor-based morphometry (TBM to investigate volume changes and the Inherited Ataxia Clinical Rating Scale to assess the clinical deficit. With respect to controls, SCA2 patients showed significant higher atrophy rates in the midbrain, including substantia nigra, basis pontis, middle cerebellar peduncles and posterior medulla corresponding to the gracilis and cuneatus tracts and nuclei, cerebellar white matter (WM and cortical gray matter (GM in the inferior portions of the cerebellar hemisphers. No differences in WM or GM volume loss were observed in the supratentorial compartment. TBM findings did not correlate with modifications of the neurological deficit. In conclusion, MRI volumetry using TBM is capable of demonstrating the progression of pontocerebellar atrophy in SCA2, supporting a possible role of MRI as biomarker in future trials.

  2. Study of Chemical Changes in Uranium Oxyfluoride Particles Progress Report March - October 2009

    Energy Technology Data Exchange (ETDEWEB)

    Kips, R; Kristo, M; Hutcheon, I

    2009-11-22

    Nuclear forensics relies on the analysis of certain sample characteristics to determine the origin and history of a nuclear material. In the specific case of uranium enrichment facilities, it is the release of trace amounts of uranium hexafluoride (UF{sub 6}) gas - used for the enrichment of uranium - that leaves a process-characteristic fingerprint. When UF{sub 6} gas interacts with atmospheric moisture, uranium oxyfluoride particles or particle agglomerates are formed with sizes ranging from several microns down to a few tens of nanometers. These particles are routinely collected by safeguards organizations, such as the International Atomic Energy Agency (IAEA), allowing them to verify whether a facility is compliant with its declarations. Spectrometric analysis of uranium particles from UF{sub 6} hydrolysis has revealed the presence of both particles that contain fluorine, and particles that do not. It is therefore assumed that uranium oxyfluoride is unstable, and decomposes to form uranium oxide. Understanding the rate of fluorine loss in uranium oxyfluoride particles, and the parameters that control it, may therefore contribute to placing boundaries on the particle's exposure time in the environment. Expressly for the purpose of this study, we prepared a set of uranium oxyfluoride particles at the Institute for Reference Materials and Measurements (EU-JRC-IRMM) from a static release of UF{sub 6} in a humid atmosphere. The majority of the samples was stored in controlled temperature, humidity and lighting conditions. Single particles were characterized by a suite of micro-analytical techniques, including NanoSIMS, micro-Raman spectrometry (MRS), scanning (SEM) and transmission (TEM) electron microscopy, energy-dispersive X-ray spectrometry (EDX) and focused ion beam (FIB). The small particle size was found to be the main analytical challenge. The relative amount of fluorine, as well as the particle chemical composition and morphology were determined at

  3. Surface analytical characterization studies of nano crystalline transition metal oxides

    International Nuclear Information System (INIS)

    Exposing stainless steel type 304L to the primary coolant in a pressurized water reactor (PWR) results in the formation of duplex oxides where the outer layer is nickel ferrite phase while the inner layer consists relatively smaller crystallites of iron chromite phase. In this context, a series of spinels containing nickel, chromium and iron with nominal composition NiCrxFe2-xO4 (x=0-2) were prepared by a sol-gel auto combustion route by using different fuels like citric acid and urea and keeping the molar ratios 1:1 and 1:3. The oxides obtained through sol gel method were sintered at 773 K for 5 h. Formation of pure crystallized NiCrxFe2-xO4 was observed for the values of x up to 1.6. However a minor amount of Cr2O3 phase was identified for higher values of x (i.e. when x=1.8 and 2.0) when 1:1 fuel ratio was used. This was over come by increasing the fuel ratio to 1:3. The obtained oxides were characterized by X-ray photoelectron microscopy, BET surface area, Raman spectroscopy, scanning electron microscopy, energy and wave length X-ray microanalysis and X-ray diffraction to determinate their structural properties. In the present study, the effect of chromium substitution in the oxide was examined by the X- ray photo electron spectroscopy (XPS) and Raman Spectroscopy. The chemical state of metal ion present in the Ni-Cr Ferrite spinel was also investigated by X-ray photo electron spectroscopy. Oxides containing chromium and iron with nickel showed a Cr2p3/2 photo peak at higher binding energy than that for chromium sesquioxide which conformed the formation of Ni-Cr ferrites. Composition of each oxide was checked using energy dispersive X-ray analysis. Raman spectra showed five Raman shifts at 190, 310, 480, 550, and 700 cm-1 respectively, conforming ferrite crystallites in the spinel structure. Analysis also revealed that the chromium substitution from x=0 to x=1 led to higher octahedral site preference energy for chromium and nickel leading to displacement of Fe3

  4. Depressive Symptoms are Related to Progression of Coronary Calcium in Midlife Women: The Study of Women’s Health Across the Nation (SWAN) Heart Study

    Science.gov (United States)

    Janssen, Imke; Powell, Lynda H.; Matthews, Karen A.; Cursio, John F.; Hollenberg, Steven M.; Sutton-Tyrrell, Kim; Bromberger, Joyce T.; Everson-Rose, Susan A.

    2011-01-01

    Background Major depression and depressive symptoms are associated with cardiovascular disease (CVD), but the impact of depression on early atherogenesis is less well known, particularly in women and minorities. This study examined whether depressive symptoms are associated with progression of coronary artery calcification (CAC) among women at mid-life. Methods The Study of Women’s Health Across the Nation (SWAN) is a longitudinal, multi-site study assessing health and psychological factors in mid-life women. An ancillary study (SWAN Heart) evaluated subclinical atherosclerosis in women who reported no history of CVD or diabetes. In 346 women, CAC was measured twice by electron beam computed tomography, an average of 2.3 years apart. Progression, defined as an increase by 10 Agatston units or more, was analyzed using relative risk regression. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression (CES-D) Scale. Results Progression of CAC was observed in 67 women (19.1%). Each 1–SD higher CES-D score at baseline related to a 25% increased risk of CAC progression [RR 1.25, CI 1.06–1.47, p=0.007], adjusting for age, time between scans, ethnicity, education, menopausal status, and known CVD risk factors. This risk was similar to the risk induced by BMI [RR 1.31, CI 1.11–1.54, p=0.001] and systolic blood pressure [RR 1.28, CI 1.06–1.55, p=0.01]. Conclusions Depressive symptoms were independently associated with progression of CAC in this cohort of midlife women. Depressive symptoms may represent a risk factor that is potentially modifiable for early prevention of CVD in women. PMID:21641367

  5. Playing with progression, immersion, and sociality: Developing a framework for studying meaning in APPMMAGs, a case study

    Directory of Open Access Journals (Sweden)

    Matt Bouchard

    2015-06-01

    Full Text Available Conventional video games are not only immersive, but also difficult to play; in addition, they require a considerable amount of time to learn and play. These features help in creating a sense of purpose or meaning in the game. However, in a game with no graphics, sound, story, or difficulty, how do players find or create this meaning for their in-game actions? This article explores Abstract Persistent Progressive Massively Multiplayer Asynchronous Games (APPMMAGs – a class of games that do not possess any of the usual features associated with conventional video games. To explore these games, a theoretical framework is proposed that examines some common rhetorics of video game meaning-making – specifically, progression, immersion, and sociality – in the context of APPMMAGs.

  6. Nuclear medicine and imaging research (quantitative studies in radiopharmaceutical science). Progress report, January 1, 1992--December 31, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, M.; Beck, R.N.

    1992-06-01

    This report describes three studies aimed at using radiolabeled pharmaceuticals to explore brain function and anatomy. The first section describes the chemical preparation of [F18]fluorinated benzamides (dopamine D-2 receptor tracers), [F18]fluorinated benzazepines (dopamine D-1 receptor tracers), and tissue distribution of [F18]-fluoxetine (serotonin reuptake site tracer). The second section relates pharmacological and behavioral studies of amphetamines. The third section reports on progress made with processing of brain images from CT, MRI and PET/SPECT with regards to brain metabolism of glucose during mental tasks.

  7. Effect of low-addition soft contact lenses with decentered optical design on myopia progression in children: a pilot study

    Directory of Open Access Journals (Sweden)

    Fujikado T

    2014-09-01

    Full Text Available Takashi Fujikado,1 Sayuri Ninomiya,2 Takuma Kobayashi,2 Asaki Suzaki,3 Mitsuhiko Nakada,3 Kohji Nishida4 1Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, 2Itami Chuo Eye Clinic, Itami, 3Menicon, Nagoya, 4Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan Purpose: To investigate the effect of low-addition soft contact lenses (CLs with decentered optical design on the progression of myopia in children in a pilot study.Subjects and methods: Twenty-four Japanese children age 10–16 years with baseline myopia of –0.75 to –3.50 D sphere and ≤1.00 D cylinder were studied. The new CLs were designed to have a nasal decentration with the optical center centered on the line of sight, and with progressive-addition power of +0.5 D peripherally. Monofocal soft CLs were used as controls. A pair of new CLs or control CLs was randomly assigned to the children, and they wore the lenses for 12 months during the first phase. Then, the type of CLs was changed, ie, a crossover design, and the children were observed for another 12 months during the second phase. The end points were changes in axial length and refractive error (spherical equivalent under cycloplegia.Results: The change of axial length in the new-CL and control-CL groups was not different between 12 months and baseline, the change of axial length between 12 months and 1 month in the new-CL group (0.09±0.08 mm was significantly smaller (47% than that in the control-CL group (0.17±0.08 mm, P<0.05. During the same period, the change of refractive error in the new-CL group was not significantly different from that in the control group. Neither the change in axial length nor refractive error in the new-CL group was significantly different from those in the control-CL group in the second phase.Conclusion: This pilot study suggests that low-addition soft CLs with decentered optical design can reduce the degree of axial

  8. Role of Lipids in the Onset, Progression and Treatment of Periodontal Disease. A Systematic Review of Studies in Humans

    Directory of Open Access Journals (Sweden)

    Alfonso Varela-López

    2016-07-01

    Full Text Available The risk of different oral problems (root caries, tooth mobility, and tooth loss can be increased by the presence of periodontal disease, which has also been associated with a growing list of systemic diseases. The presence of some bacteria is the primary etiology of this disease; a susceptible host is also necessary for disease initiation. In this respect, the progression of periodontal disease and healing of the periodontal tissues can be modulated by nutritional status. To clarify the role of lipids in the establishment, progression, and/or treatment of this pathology, a systematic review was conducted of English-written literature in PubMed until May 2016, which included research on the relationship of these dietary components with the onset and progression of periodontal disease. According to publication type, randomized-controlled trials, cohort, case-control and cross-sectional studies were included. Among all the analyzed components, those that have any effect on oxidative stress and/or inflammation seem to be the most interesting according to current evidence. On one hand, there is quite a lot of information in favor of a positive role of n-3 fatty acids, due to their antioxidant and immunomodulatory effects. On the other hand, saturated fat-rich diets increase oxidative stress as well the as intensity and duration of inflammatory processes, so they must be avoided.

  9. Role of Lipids in the Onset, Progression and Treatment of Periodontal Disease. A Systematic Review of Studies in Humans.

    Science.gov (United States)

    Varela-López, Alfonso; Giampieri, Francesca; Bullón, Pedro; Battino, Maurizio; Quiles, José L

    2016-01-01

    The risk of different oral problems (root caries, tooth mobility, and tooth loss) can be increased by the presence of periodontal disease, which has also been associated with a growing list of systemic diseases. The presence of some bacteria is the primary etiology of this disease; a susceptible host is also necessary for disease initiation. In this respect, the progression of periodontal disease and healing of the periodontal tissues can be modulated by nutritional status. To clarify the role of lipids in the establishment, progression, and/or treatment of this pathology, a systematic review was conducted of English-written literature in PubMed until May 2016, which included research on the relationship of these dietary components with the onset and progression of periodontal disease. According to publication type, randomized-controlled trials, cohort, case-control and cross-sectional studies were included. Among all the analyzed components, those that have any effect on oxidative stress and/or inflammation seem to be the most interesting according to current evidence. On one hand, there is quite a lot of information in favor of a positive role of n-3 fatty acids, due to their antioxidant and immunomodulatory effects. On the other hand, saturated fat-rich diets increase oxidative stress as well the as intensity and duration of inflammatory processes, so they must be avoided. PMID:27463711

  10. Role of Lipids in the Onset, Progression and Treatment of Periodontal Disease. A Systematic Review of Studies in Humans

    Science.gov (United States)

    Varela-López, Alfonso; Giampieri, Francesca; Bullón, Pedro; Battino, Maurizio; Quiles, José L.

    2016-01-01

    The risk of different oral problems (root caries, tooth mobility, and tooth loss) can be increased by the presence of periodontal disease, which has also been associated with a growing list of systemic diseases. The presence of some bacteria is the primary etiology of this disease; a susceptible host is also necessary for disease initiation. In this respect, the progression of periodontal disease and healing of the periodontal tissues can be modulated by nutritional status. To clarify the role of lipids in the establishment, progression, and/or treatment of this pathology, a systematic review was conducted of English-written literature in PubMed until May 2016, which included research on the relationship of these dietary components with the onset and progression of periodontal disease. According to publication type, randomized-controlled trials, cohort, case-control and cross-sectional studies were included. Among all the analyzed components, those that have any effect on oxidative stress and/or inflammation seem to be the most interesting according to current evidence. On one hand, there is quite a lot of information in favor of a positive role of n-3 fatty acids, due to their antioxidant and immunomodulatory effects. On the other hand, saturated fat-rich diets increase oxidative stress as well the as intensity and duration of inflammatory processes, so they must be avoided. PMID:27463711

  11. Study on Causes of Slow Progress in Promoting the Application of Food Traceability System in China

    Institute of Scientific and Technical Information of China (English)

    Pinghua; HE; Peisi; CHEN

    2014-01-01

    Chinese government has attempted to promote food traceability system with all strength,but the application process of this system is very slow. The reason is that the adopters have a low level of system application,which causes the system to be invalid at the source of traceability. This paper applies literature research method to analyze the influencing factors for slow application process of the food traceability system in China from various angles including manufacturer,technology,consumer and law,and further concludes that the applying intention of manufacturers,cognizing and purchasing intentions of consumers,and legal environment are important factors for slow progress of system application. On the basis of the research conclusions,the paper proposes practical ways for better construction of food traceability system in China.

  12. Study progression in application of process analytical technologies on film coating

    Directory of Open Access Journals (Sweden)

    Tingting Peng

    2015-06-01

    Full Text Available Film coating is an important unit operation to produce solid dosage forms, thereby, the monitoring of this process is helpful to find problems in time and improve the quality of coated products. Traditional methods adopted to monitor this process include measurement of coating weight gain, performance of disintegration and dissolution test, etc. However, not only do these methods cause destruction to the samples, but also consume time and energy. There have recently emerged the applications of process analytical technologies (PAT on film coating, especially some novel spectroscopic and imaging technologies, which have the potential to real-time track the progress in film coating and optimize production efficiency. This article gives an overview on the application of such technologies for film coating, with the goal to provide a reference for the further researches.

  13. Progress report on SYVAC chemical modelling studies during 1984/85

    International Nuclear Information System (INIS)

    This report summarises progress made from April 1984 to May 1985 on chemical modelling within the DOE SYVAC project. Three new computer programs; the reaction path codes, PHREEQE and EQ3/6, and the chemical transport simulator CHEMTRN, have been acquired. Their applicability, overall capabilities, ease of use and database requirements are assessed. Coupled approaches to geochemical - hydrological modelling and the use of CHEMTRN is discussed. Modelling has been performed in connection with the ''Dry Run Assessment''. Speciation and solubilities of the actinides were simulated, assuming the vault to be a concrete solution and the geosphere to be represented by Harwell site groundwater analyses. Model verification and validation by collaboration with experimentalists and other modellers is discussed. (author)

  14. Structured approach to design of diagnostic test evaluation studies for chronic progressive infections in animals

    DEFF Research Database (Denmark)

    Nielsen, Søren Saxmose; Toft, Nils; Gardner, Ian Andrew

    2011-01-01

    Diagnostic test evaluations (DTEs) for chronic infections are challenging because a protracted incubation period has to be considered in the design of the DTE, and the adverse effects of infection may be widespread and progressive over an animal's entire life. Frequently, the specific purpose of...... analyte) than originally intended. The objective of this paper is to outline a structured approach to the design and conduct of a DTE for diagnostic tests used for chronic infections in animals, and intended for different purposes. We describe the process from reflections about test purpose and the...... the test is not formally considered when a test is evaluated. Therefore, the result is often a DTE where test sensitivity and specificity estimates are biased, either because of problems with establishing the true infection status or because the test detects another aspect of the infection (and...

  15. Nuclear powered satellite studies. Annual progress report, July 1, 1978-June 30, 1979

    International Nuclear Information System (INIS)

    Progress achieved during the period July 1, 1978 to June 30, 1979, on US DOE contract No. EY-76-S-02-4045.A002 is reported. Discussions of several pertinent aspects are included, e.g., schedule, personnel, technology developments, and plans. The reporting period represents the third year of activities of a project which is designed to provide continuing support in the area of nuclear space power technology. Important results have been obtained and communicated to the scientific community via publications and presentations. Project personnel have participated in point design efforts, a NASA Space Power Committee, and periodically provide support to Department of Energy activities as the need arises. The report is intended to summarize activities over the past year and provide a basis for continued project support by US DOE

  16. Dynamical studies of molecular systems. Progress report, February 1, 1982-October 15, 1982

    International Nuclear Information System (INIS)

    During the past year, progress was achieved on several projects under this contract. Research was carried out in the general areas of collision dynamics and chemical kinetics. In summary, research on the following topics was pursued. (I) a new multiple (mass ratio) scale analysis of atom-diatom collisions; (II) exact scattering solutions in an Energy Sudden (ES) representation; (III) rotational relaxation rates in HF and Ar-HF from the direct inversion of pressure broadened linewidths; (IV) chemical sensitivity analysis theory with applications to molecular dynamics and kinetics; (V) derived sensitivity densities in chemical kinetics: a new computational approach with applications; (VI) feature sensitivity analysis in chemical kinetics; and (VII) application of moments to the general linear multicomponent reaction-diffusion equation. This work is briefly reviewed

  17. Molecular characterization of the lignin-forming peroxidase: Role in growth, development and response to stress. Progress summary report, April 1, 1992--March 31, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Lagrimini, L.M.

    1993-03-01

    This laboratory has continued its comprehensive study of the structure and function of plant peroxidases and their genes. Specifically, we are characterizing the anionic peroxidase of tobacco. During the past year we have completed the nucleotide sequence of the tobacco anionic peroxidase gene, joined the anionic peroxidase promoter to {Beta}-glucuronidase and demonstrated expression in transformed plants, measured lignin, auxin, and ethylene levels in transgenic tobacco plants over-expressing the anionic peroxidase, developed chimeric peroxidase genes to over-or under-express the anionic peroxidase in tissue specific manner in transgenic plants, and over-expressed the tobacco anionic peroxidase in transgenic tomato and sweetgum plants.

  18. Genotype-phenotype correlation for DFNA22: characterization of non-syndromic, autosomal dominant, progressive sensorineural hearing loss due to MYO6 mutations

    DEFF Research Database (Denmark)

    Tranebjærg, Lisbeth; Rendtorff, Nanna D; Topsakal, Vedat;

    2010-01-01

    Clinical and audiological examination was done in 2 Belgian families with autosomal dominant sensorineural hearing loss (SNHL) linked to DFNA22. Nineteen subjects in family 1 had mild to moderate SNHL starting in the third decade. The hearing loss was characterized by a flat audiogram affecting all......Hz. For all hitherto known DFNA22 families the audiological and clinical characteristics were correlated with the molecular data. This study describes the phenotype of 2 Belgian families with SNHL linked to DFNA22, both with a pathogenic change in the deafness gene MYO6. The phenotypes of all hitherto...

  19. Studies on the roles of stromal CXCL14 in tumor growth, progression and metastasis formation

    OpenAIRE

    Sjöberg, Elin

    2016-01-01

    Cancer consists of several diseases that are characterized by accumulation of genetic and epigenetic alterations that provide cells with certain capabilities to form tumors. Among these acquired capabilities are enhanced invasion that allow cancer cells to escape from the primary tumor, enter the circulation and eventually reach distant tissues where they form metastasis. Breast and prostate cancer are the most common cancers in Sweden with about 9000 new cases diagnosed each y...

  20. Field cage studies and progressive evaluation of genetically-engineered mosquitoes.

    Directory of Open Access Journals (Sweden)

    Luca Facchinelli

    Full Text Available BACKGROUND: A genetically-engineered strain of the dengue mosquito vector Aedes aegypti, designated OX3604C, was evaluated in large outdoor cage trials for its potential to improve dengue prevention efforts by inducing population suppression. OX3604C is engineered with a repressible genetic construct that causes a female-specific flightless phenotype. Wild-type females that mate with homozygous OX3604C males will not produce reproductive female offspring. Weekly introductions of OX3604C males eliminated all three targeted Ae. aegypti populations after 10-20 weeks in a previous laboratory cage experiment. As part of the phased, progressive evaluation of this technology, we carried out an assessment in large outdoor field enclosures in dengue endemic southern Mexico. METHODOLOGY/PRINCIPAL FINDINGS: OX3604C males were introduced weekly into field cages containing stable target populations, initially at 10:1 ratios. Statistically significant target population decreases were detected in 4 of 5 treatment cages after 17 weeks, but none of the treatment populations were eliminated. Mating competitiveness experiments, carried out to explore the discrepancy between lab and field cage results revealed a maximum mating disadvantage of up 59.1% for OX3604C males, which accounted for a significant part of the 97% fitness cost predicted by a mathematical model to be necessary to produce the field cage results. CONCLUSIONS/SIGNIFICANCE: Our results indicate that OX3604C may not be effective in large-scale releases. A strain with the same transgene that is not encumbered by a large mating disadvantage, however, could have improved prospects for dengue prevention. Insights from large outdoor cage experiments may provide an important part of the progressive, stepwise evaluation of genetically-engineered mosquitoes.