WorldWideScience

Sample records for changing transmission settings

  1. Dynamic Experimental Research on Setting Signal Transmission of Induction Setting System in Muzzle

    Institute of Scientific and Technical Information of China (English)

    HUANG Xue-gong

    2009-01-01

    Muzzle induction setting is a high speed dynamic process. Based on analyzing the process of the projectile flying through an induction setting field, an experimental method is studied to test the effect of high speed plasma gas and high speed projectile on the induction setting system. Three tests are designed. The real-time coupling curves of induction setting signal are tested by coupling a test coil. The experimental results indicate that the electromagnetic field formed by high speed plasma gas can influence the signal transmission of induction setting system, and the influence can be reduced by opening some vents on muzzle; the high speed projectile changed the distributing characteristics of electromagnetic field in the induction setting field to reduce the amplitude of induction coupling signal.

  2. Enterprise Projects Set Risk Element Transmission Chaotic Genetic Model

    Directory of Open Access Journals (Sweden)

    Cunbin Li

    2012-08-01

    Full Text Available In order to research projects set risk transfer process and improve risk management efficiency in projects management, combining chaos theory and genetic algorithm, put forward enterprise projects set risk element transmission chaos genetic model. Using logistic chaos mapping and chebyshev chaos mapping mixture, constructed a hybrid chaotic mapping system. The steps of adopting hybrid chaos mapping for genetic operation include projects set initialization, calculation of fitness, selection, crossover and mutation operators, fitness adjustment and condition judgment. The results showed that the model can simulate enterprise projects set risk transmission process very well and it also provides the basis for the enterprise managers to make decisions.

  3. Enterprise Projects Set Risk Element Transmission Chaotic Genetic Model

    OpenAIRE

    Cunbin Li; Peng Li; Gongshu Lu

    2012-01-01

    In order to research projects set risk transfer process and improve risk management efficiency in projects management, combining chaos theory and genetic algorithm, put forward enterprise projects set risk element transmission chaos genetic model. Using logistic chaos mapping and chebyshev chaos mapping mixture, constructed a hybrid chaotic mapping system. The steps of adopting hybrid chaos mapping for genetic operation include projects set initialization, calculation of fitness, selection, c...

  4. Public Transportation and Tuberculosis Transmission in a High Incidence Setting

    OpenAIRE

    Zamudio, C; Krapp, F.; Choi, HW; Shah, L.; Ciampi, A.; Gotuzzo, E; J. Heymann; Seas, C; Brewer, TF

    2015-01-01

    © 2015 Zamudio et al. Background: Tuberculosis (TB) transmission may occur with exposure to an infectious contact often in the setting of household environments, but extra-domiciliary transmission also may happen. We evaluated if using buses and/or minibuses as public transportation was associated with acquiring TB in a high incidence urban district in Lima, Peru. Methods: Newly diagnosed TB cases with no history of previous treatment and community controls were recruited from August to Decem...

  5. Instruction manual model 600F, data transmission test set

    Science.gov (United States)

    1972-01-01

    Information necessary for the operation and maintenance of the Model 600F Data Transmission Test Set is presented. A description is contained of the physical and functional characteristics; pertinent installation data; instructions for operating the equipment; general and detailed principles of operation; preventive and corrective maintenance procedures; and block, logic, and component layout diagrams of the equipment and its major component assemblies.

  6. Quantifying Transmission of Clostridium difficile within and outside Healthcare Settings

    Science.gov (United States)

    Olsen, Margaret A.; Dubberke, Erik R.; Galvani, Alison P.; Townsend, Jeffrey P.

    2016-01-01

    To quantify the effect of hospital and community-based transmission and control measures on Clostridium difficile infection (CDI), we constructed a transmission model within and between hospital, community, and long-term care-facility settings. By parameterizing the model from national databases and calibrating it to C. difficile prevalence and CDI incidence, we found that hospitalized patients with CDI transmit C. difficile at a rate 15 (95% CI 7.2–32) times that of asymptomatic patients. Long-term care facility residents transmit at a rate of 27% (95% CI 13%–51%) that of hospitalized patients, and persons in the community at a rate of 0.1% (95% CI 0.062%–0.2%) that of hospitalized patients. Despite lower transmission rates for asymptomatic carriers and community sources, these transmission routes have a substantial effect on hospital-onset CDI because of the larger reservoir of hospitalized carriers and persons in the community. Asymptomatic carriers and community sources should be accounted for when designing and evaluating control interventions. PMID:26982504

  7. An ultrasonic through-transmission technique for monitoring the setting of injectable calcium phosphate cement.

    Science.gov (United States)

    Rajzer, Izabella; Piekarczyk, Wojciech; Castaño, Oscar

    2016-10-01

    An ultrasound through-transmission method to monitor the setting process of injectable calcium phosphate bone cements in body fluids is presented. This method can be used to determine the acoustic properties of the bone cement as it sets, which are linked to its material properties and provide some information about changes occurring within the cement. The development of the methodology of ultrasonic testing and execution of velocity measurements of the longitudinal and transverse waves using the through-transmission method made it possible to determine the material constants of samples during the setting and hardening process of an injectable cement paste in physiological fluids (i.e. the Young's modulus (E), the Poisson ratio (ν) and the shear modulus (G)), and to determine the degree of anisotropy of wave velocity in the samples. A strong advantage of the proposed method is that it is non-destructive, and the same sample can be used to monitor the whole process of the cement setting. The testing was performed on premixed and injectable calcium phosphate (CPC)/chitosan blend, where glycerol was used as a liquid phase. Comparisons between ultrasonic velocity and empirical tests such as compressive strength, porosity measurement, FTIR, SEM and XRD analysis at different days of immersion in Ringer's solutions showed that the ultrasonic velocity can be very useful to provide in situ information about changes occurring within the cement. PMID:27287094

  8. Framing climate change in a popularised setting:

    DEFF Research Database (Denmark)

    Laursen, Anne Lise; Rasmussen, Kirsten Wølch; Engberg, Jan

    Framing climate change in a popularised setting: The case of the COP conferences The major project from which this presentation has emerged intends to analyze the media communication in connection with mainly the COP15 conference in Copenhagen on climate change 2009 in a number of European...... conference. In our part of the project, we look at how knowledge is created via the choice of metaphors. On the basis of an analysis of the framing of the COP15 conference and its goals as presented in the introductory statements by the two Danish presidents of the conference we have found a range of salient...... the introductory statement by the president of the Cancún conference in 2010 in order to assess possible influences in the framing from the national and the political setting....

  9. Distance Protection Settings Based Artificial Neural Network in Presence of TCSR on Electrical Transmission Line

    Directory of Open Access Journals (Sweden)

    Mohamed Zellagui

    2012-11-01

    Full Text Available This research paper study the performance of distance relays setting based analytic (AM and artificial neural network (ANN method for a 400 kV high voltage transmission line in Eastern Algerian transmission networks at Sonelgaz Group compensated by series Flexible AC Transmission System (FACTS i.e. Thyristor Controlled Series Reactor (TCSR connected at midpoint of the electrical transmission line. The facts are used for controlling transmission voltage, power flow, reactive power, and damping of power system oscillations in high power transfer levels. This paper studies the effects of TCSR insertion on the total impedance of a transmission line protected by distance relay and the modified setting zone protection in capacitive and inductive boost mode for three zones. Two different techniques have been investigated in order to prevent circuit breaker nuisance tripping to improve the performances of the distance relay protection.

  10. Vulnerability to changes in malaria transmission due to climate change in West Africa

    Science.gov (United States)

    Yamana, T. K.; Eltahir, E. A.

    2012-12-01

    Malaria transmission in West Africa is strongly tied to climate; temperature affects the development rate of the malaria parasite, as well as the survival of the mosquitoes that transmit the disease, and rainfall is tied to mosquito abundance, as the vector lays its eggs in rain-fed water pools. As a result, the environmental suitability for malaria transmission in this region is expected to change as temperatures rise and rainfall patterns are altered. The vulnerability to changes in transmission varies throughout West Africa. Areas where malaria prevalence is already very high will be less sensitive to changes in transmission. Increases in environmental suitability for malaria transmission in the most arid regions may still be insufficient to allow sustained transmission. However, areas were malaria transmission currently occurs at low levels are expected to be the most sensitive to changes in environmental suitability for transmission. Here, we use data on current environment and malaria transmission rates to highlight areas in West Africa that we expect to be most vulnerable to an increase in malaria under certain climate conditions. We then analyze climate predictions from global climate models in vulnerable areas, and make predictions for the expected change in environmental suitability for malaria transmission using the Hydrology, Entomology and Malaria Transmission Simulator (HYDREMATS), a mechanistic model developed to simulate village-scale response of malaria transmission to environmental variables in West Africa.

  11. 46 CFR 154.1846 - Relief valves: Changing set pressure.

    Science.gov (United States)

    2010-10-01

    ...) At each relief valve. ... 46 Shipping 5 2010-10-01 2010-10-01 false Relief valves: Changing set pressure. 154.1846 Section... Relief valves: Changing set pressure. The master shall: (a) Supervise the changing of the set pressure...

  12. Justification and Tools for Change: Scene Setting

    International Nuclear Information System (INIS)

    The paper seeks to set the scene by providing a summary of some key points in the social, legal, philosophical, medical radiological and radiological protection background to this meeting. In addition, it identifies the hopes and expectations held by the organizers when they took the initiative to organize the meeting. (author)

  13. Entomological Monitoring and Evaluation: Diverse Transmission Settings of ICEMR Projects Will Require Local and Regional Malaria Elimination Strategies

    Science.gov (United States)

    Conn, Jan E.; Norris, Douglas E.; Donnelly, Martin J.; Beebe, Nigel W.; Burkot, Thomas R.; Coulibaly, Mamadou B.; Chery, Laura; Eapen, Alex; Keven, John B.; Kilama, Maxwell; Kumar, Ashwani; Lindsay, Steve W.; Moreno, Marta; Quinones, Martha; Reimer, Lisa J.; Russell, Tanya L.; Smith, David L.; Thomas, Matthew B.; Walker, Edward D.; Wilson, Mark L.; Yan, Guiyun

    2015-01-01

    The unprecedented global efforts for malaria elimination in the past decade have resulted in altered vectorial systems, vector behaviors, and bionomics. These changes combined with increasingly evident heterogeneities in malaria transmission require innovative vector control strategies in addition to the established practices of long-lasting insecticidal nets and indoor residual spraying. Integrated vector management will require focal and tailored vector control to achieve malaria elimination. This switch of emphasis from universal coverage to universal coverage plus additional interventions will be reliant on improved entomological monitoring and evaluation. In 2010, the National Institutes for Allergies and Infectious Diseases (NIAID) established a network of malaria research centers termed ICEMRs (International Centers for Excellence in Malaria Research) expressly to develop this evidence base in diverse malaria endemic settings. In this article, we contrast the differing ecology and transmission settings across the ICEMR study locations. In South America, Africa, and Asia, vector biologists are already dealing with many of the issues of pushing to elimination such as highly focal transmission, proportionate increase in the importance of outdoor and crepuscular biting, vector species complexity, and “sub patent” vector transmission. PMID:26259942

  14. Entomological Monitoring and Evaluation: Diverse Transmission Settings of ICEMR Projects Will Require Local and Regional Malaria Elimination Strategies.

    Science.gov (United States)

    Conn, Jan E; Norris, Douglas E; Donnelly, Martin J; Beebe, Nigel W; Burkot, Thomas R; Coulibaly, Mamadou B; Chery, Laura; Eapen, Alex; Keven, John B; Kilama, Maxwell; Kumar, Ashwani; Lindsay, Steve W; Moreno, Marta; Quinones, Martha; Reimer, Lisa J; Russell, Tanya L; Smith, David L; Thomas, Matthew B; Walker, Edward D; Wilson, Mark L; Yan, Guiyun

    2015-09-01

    The unprecedented global efforts for malaria elimination in the past decade have resulted in altered vectorial systems, vector behaviors, and bionomics. These changes combined with increasingly evident heterogeneities in malaria transmission require innovative vector control strategies in addition to the established practices of long-lasting insecticidal nets and indoor residual spraying. Integrated vector management will require focal and tailored vector control to achieve malaria elimination. This switch of emphasis from universal coverage to universal coverage plus additional interventions will be reliant on improved entomological monitoring and evaluation. In 2010, the National Institutes for Allergies and Infectious Diseases (NIAID) established a network of malaria research centers termed ICEMRs (International Centers for Excellence in Malaria Research) expressly to develop this evidence base in diverse malaria endemic settings. In this article, we contrast the differing ecology and transmission settings across the ICEMR study locations. In South America, Africa, and Asia, vector biologists are already dealing with many of the issues of pushing to elimination such as highly focal transmission, proportionate increase in the importance of outdoor and crepuscular biting, vector species complexity, and "sub patent" vector transmission. PMID:26259942

  15. Research and Development of Engine-Generator Set Control System for Tracked Vehicle Electric Transmission System

    Institute of Scientific and Technical Information of China (English)

    HUANG Ying; HUANG Qian; SUN Feng-chun; LIU Bo-lan; LIU Jia

    2007-01-01

    As an energy generating equipment, the engine-generator set supplies power to the electric transmission. Therefore, its control is one of the key technologies of electric vehicles. Based on the discussion about the demands to the engine-generator set in tracked vehicles, the detailed function of engine-generator and the control strategy are determined. The hardware and software of the control system are also developed and tested in a prototype vehicle. The experiment results show that the control system has good reliability and can satisfy the power requirements of vehicles under all operating conditions.

  16. Malaria transmission potential could be reduced with current and future climate change.

    Science.gov (United States)

    Murdock, C C; Sternberg, E D; Thomas, M B

    2016-01-01

    Several studies suggest the potential for climate change to increase malaria incidence in cooler, marginal transmission environments. However, the effect of increasing temperature in warmer regions where conditions currently support endemic transmission has received less attention. We investigate how increases in temperature from optimal conditions (27 °C to 30 °C and 33 °C) interact with realistic diurnal temperature ranges (DTR: ± 0 °C, 3 °C, and 4.5 °C) to affect the ability of key vector species from Africa and Asia (Anopheles gambiae and An. stephensi) to transmit the human malaria parasite, Plasmodium falciparum. The effects of increasing temperature and DTR on parasite prevalence, parasite intensity, and mosquito mortality decreased overall vectorial capacity for both mosquito species. Increases of 3 °C from 27 °C reduced vectorial capacity by 51-89% depending on species and DTR, with increases in DTR alone potentially halving transmission. At 33 °C, transmission potential was further reduced for An. stephensi and blocked completely in An. gambiae. These results suggest that small shifts in temperature could play a substantial role in malaria transmission dynamics, yet few empirical or modeling studies consider such effects. They further suggest that rather than increase risk, current and future warming could reduce transmission potential in existing high transmission settings. PMID:27324146

  17. Malaria transmission potential could be reduced with current and future climate change

    Science.gov (United States)

    Murdock, C. C.; Sternberg, E. D.; Thomas, M. B.

    2016-01-01

    Several studies suggest the potential for climate change to increase malaria incidence in cooler, marginal transmission environments. However, the effect of increasing temperature in warmer regions where conditions currently support endemic transmission has received less attention. We investigate how increases in temperature from optimal conditions (27 °C to 30 °C and 33 °C) interact with realistic diurnal temperature ranges (DTR: ± 0 °C, 3 °C, and 4.5 °C) to affect the ability of key vector species from Africa and Asia (Anopheles gambiae and An. stephensi) to transmit the human malaria parasite, Plasmodium falciparum. The effects of increasing temperature and DTR on parasite prevalence, parasite intensity, and mosquito mortality decreased overall vectorial capacity for both mosquito species. Increases of 3 °C from 27 °C reduced vectorial capacity by 51–89% depending on species and DTR, with increases in DTR alone potentially halving transmission. At 33 °C, transmission potential was further reduced for An. stephensi and blocked completely in An. gambiae. These results suggest that small shifts in temperature could play a substantial role in malaria transmission dynamics, yet few empirical or modeling studies consider such effects. They further suggest that rather than increase risk, current and future warming could reduce transmission potential in existing high transmission settings. PMID:27324146

  18. Detecting a trend change in cross-border epidemic transmission

    Science.gov (United States)

    Maeno, Yoshiharu

    2016-09-01

    A method for a system of Langevin equations is developed for detecting a trend change in cross-border epidemic transmission. The equations represent a standard epidemiological SIR compartment model and a meta-population network model. The method analyzes a time series of the number of new cases reported in multiple geographical regions. The method is applicable to investigating the efficacy of the implemented public health intervention in managing infectious travelers across borders. It is found that the change point of the probability of travel movements was one week after the WHO worldwide alert on the SARS outbreak in 2003. The alert was effective in managing infectious travelers. On the other hand, it is found that the probability of travel movements did not change at all for the flu pandemic in 2009. The pandemic did not affect potential travelers despite the WHO alert.

  19. Simulation method for transmission-type radio-frequency single-electron transistor (RF-SET) operation by SPICE

    International Nuclear Information System (INIS)

    An efficient simulation method for transmission-type radio-frequency single-electron transistors (RF-SETs) is developed. By introducing equivalent circuits of propagating microwaves through RF cables, we solve the master equation for RF-SETs self-consistently by using the conventional circuit simulator SPICE together with the SET current model. By examining transmitted waves from the transmission-type RF-SET, we show that the developed method successfully reproduces the numerical reference methods (calculated self- consistently). We also show that our method provides simple and fast ways to simulate and analyze RF-SETs even under complicated circuit geometry and in high frequencies over GHz. Based on the developed simulation method, we introduce the modulation technique to estimate the charge sensitivity of the transmission-type RF-SET

  20. Simulation method for transmission-type radio-frequency single-electron transistor (RF-SET) operation by SPICE

    Science.gov (United States)

    Yu, Yun Seop; Oh, Jung Hyun; Kim, Hee Tae; Kim, Yong Gyu; Son, Seung Hun; Choi, Bum Ho; Hwang, Sung Woo; Ahn, Doyel

    2009-02-01

    An efficient simulation method for transmission-type radio-frequency single-electron transistors (RF-SETs) is developed. By introducing equivalent circuits of propagating microwaves through RF cables, we solve the master equation for RF-SETs self-consistently by using the conventional circuit simulator SPICE together with the SET current model. By examining transmitted waves from the transmission-type RF-SET, we show that the developed method successfully reproduces the numerical reference methods (calculated self- consistently). We also show that our method provides simple and fast ways to simulate and analyze RF-SETs even under complicated circuit geometry and in high frequencies over GHz. Based on the developed simulation method, we introduce the modulation technique to estimate the charge sensitivity of the transmission-type RF-SET.

  1. Picture this: Managed change and resistance in business network settings

    DEFF Research Database (Denmark)

    Kragh, Hanne; Andersen, Poul Houman

    2009-01-01

    This paper discusses change management in networks. The literature on business networks tends to downplay the role of managerial initiative in network change. The change management literature addresses such initiative, but with its single-firm perspective it overlooks the interdependence of network...... actors. In exploring the void between these two streams of literature, we deploy the concept of network pictures to discuss managed change in network settings. We analyze a change project from the furniture industry and address the consequences of attempting to manage change activities in a network...... context characterized by limited managerial authority over these activities. Our analysis suggests that change efforts unfold as a negotiated process during which the change project is re-negotiated to fit the multiple actor constituencies. The degree of overlap in the co-existing network pictures of the...

  2. A Comparative Study of Impact Series FACTS Devices on Distance Relay Setting in 400 kV Transmission Line

    Directory of Open Access Journals (Sweden)

    ZELLAGUI Mohamed

    2012-10-01

    Full Text Available This research paper presents a comparative study of the performance of distance protection for transmission line 400 kV in Algerian transmission networks at Group Sonelgaz (Algerian Company ofElectricity and Gas compensated by two different series Flexible Alternative Current Transmission System (FACTS i.e. GTO Controlled Series Capacitor (GCSCand Thyristor Controlled Series Capacitor (TCSC connected at midpoint of an electrical transmission line.The facts are used for controlling transmission voltage, power flow and reactive power in high power transfer levels. This paper studies the effects of angle variation and controlled GCSC and TCSC insertion on the total impedance of a transmission line protected by MHO distance relay. The modified setting zone protection (resistance and reactance in capacitive and inductive boost mode for three forward zones and one reverse zone are investigated in order to improve the performances of distance protection. The simulationresults are performed in MATLAB software.

  3. Comparing Effects of TCR and TSC on MHO Distance Protection Setting in 400 kV Algerian Transmission Line

    Directory of Open Access Journals (Sweden)

    Mohamed ZELLAGUI

    2012-11-01

    Full Text Available This paper presents a study on the performances of distance relays setting in 400 kV in Eastern Algerian transmission networks at Sonelgaz Group (Algerian company of Electrical and Gas compensated by shunt Flexible AC Transmission System (FACTS. The facts are used for controlling transmission voltage, power flow, reactive power, and damping of power system oscillations in high power transfer levels. The effects of SVC devices i.e. Thyristor Controlled Reactor (TCR and the Thyristor Switched Capacitors (TSC insertion, on the total impedance of a transmission line protected by MHO distance relay are investigated. The modified setting zones protections for three forward zones (Z1, Z2 and Z3 have been calculated in order to improve the performances of distance relay protection and prevent circuit breaker nuisance tripping.

  4. Electricity transmission arrangements in Great Britain: Time for change?

    International Nuclear Information System (INIS)

    In Great Britain (GB) and across Europe significant investment in electricity transmission is expected over the coming years as decarbonisation and market integration efforts are intensified. However, there is also significant uncertainty with the amount, location and timing of new generation connection, which in turn will drive the transmission investment needs. Given the absence of efficient market design, we identify three key areas of concern with the current transmission investment arrangements: (i) a mis-aligned incentives framework for transmission investment and operation; (ii) lack of coordination of investment and operation; and (iii) conflicts of interest. We then propose three options for future evolution of transmission regimes, which cover the full spectrum of institutional arrangements with respect to transmission planning and delivery, i.e. how and who plans, owns, builds and operates the transmission system. For each option we present: key characteristics; evolution of the current regimes; the ability of the option to address the concerns; and key strengths and weaknesses. Overall, we conclude in the case of GB (this conclusion could be extended to other European countries) that the most appropriate option would be that of an Independent System Operator (ISO) who would be responsible for planning and operating the transmission system. - Highlights: • We identify three key areas of concern with the current transmission arrangements. • We then propose three options for transmission network planning and delivery. • Key strengths and weaknesses of each above option are identified and studied. • We conclude that the most appropriate option for GB would be that of an ISO

  5. A hybrid particle swarm optimization approach with neural network and set pair analysis for transmission network planning

    Institute of Scientific and Technical Information of China (English)

    刘吉成; 颜苏莉; 乞建勋

    2008-01-01

    Transmission network planning (TNP) is a large-scale, complex, with more non-linear discrete variables and the multi-objective constrained optimization problem. In the optimization process, the line investment, network reliability and the network loss are the main objective of transmission network planning. Combined with set pair analysis (SPA), particle swarm optimization (PSO), neural network (NN), a hybrid particle swarm optimization model was established with neural network and set pair analysis for transmission network planning (HPNS). Firstly, the contact degree of set pair analysis was introduced, the traditional goal set was converted into the collection of the three indicators including the identity degree, difference agree and contrary degree. On this bases, using shi(H), the three objective optimization problem was converted into single objective optimization problem. Secondly, using the fast and efficient search capabilities of PSO, the transmission network planning model based on set pair analysis was optimized. In the process of optimization, by improving the BP neural network constantly training so that the value of the fitness function of PSO becomes smaller in order to obtain the optimization program fitting the three objectives better. Finally, compared HPNS with PSO algorithm and the classic genetic algorithm, HPNS increased about 23% efficiency than THA, raised about 3.7% than PSO and improved about 2.96% than GA.

  6. A general approach to belief change in answer set programming

    CERN Document Server

    Delgrande, James; Tompits, Hans; Woltran, Stefan

    2009-01-01

    We address the problem of belief change in (nonmonotonic) logic programming under answer set semantics. Unlike previous approaches to belief change in logic programming, our formal techniques are analogous to those of distance-based belief revision in propositional logic. In developing our results, we build upon the model theory of logic programs furnished by SE models. Since SE models provide a formal, monotonic characterisation of logic programs, we can adapt techniques from the area of belief revision to belief change in logic programs. We introduce methods for revising and merging logic programs, respectively. For the former, we study both subset-based revision as well as cardinality-based revision, and we show that they satisfy the majority of the AGM postulates for revision. For merging, we consider operators following arbitration merging and IC merging, respectively. We also present encodings for computing the revision as well as the merging of logic programs within the same logic programming framework...

  7. Implementing culture change in long-term dementia care settings.

    Science.gov (United States)

    McGreevy, Jessica

    2016-01-01

    The approach to nursing in long-term care settings for people living with dementia continues to evolve from a traditional, task-oriented culture to one that is person-centred. Such change can be difficult to manage and may encounter considerable opposition; having an understanding of change management and leadership styles may help to make this transition easier. This article discusses the differences between task-oriented and person-centred care, theories of management, motivation and leadership styles, and focuses on those that are most appropriate for this type of change. An improved understanding of these theories will enable nurses to support others in the delivery of person-centred care. PMID:26938420

  8. Influence of contact definitions in assessment of the relative importance of social settings in disease transmission risk.

    Directory of Open Access Journals (Sweden)

    Kirsty J Bolton

    Full Text Available BACKGROUND: Realistic models of disease transmission incorporating complex population heterogeneities require input from quantitative population mixing studies. We use contact diaries to assess the relative importance of social settings in respiratory pathogen spread using three measures of person contact hours (PCH as proxies for transmission risk with an aim to inform bipartite network models of respiratory pathogen transmission. METHODS AND FINDINGS: Our survey examines the contact behaviour for a convenience sample of 65 adults, with each encounter classified as occurring in a work, retail, home, social, travel or "other" setting. The diary design allows for extraction of PCH-interaction (cumulative time in face-face conversational or touch interaction with contacts--analogous to the contact measure used in several existing surveys--as well as PCH-setting (product of time spent in setting and number of people present and PCH-reach (product of time spent in setting and number of people in close proximity. Heterogeneities in day-dependent distribution of risk across settings are analysed using partitioning and cluster analyses and compared between days and contact measures. Although home is typically the highest-risk setting when PCH measures isolate two-way interactions, its relative importance compared to social and work settings may reduce when adopting a more inclusive contact measure that considers the number and duration of potential exposure events. CONCLUSIONS: Heterogeneities in location-dependent contact behaviour as measured by contact diary studies depend on the adopted contact definition. We find that contact measures isolating face-face conversational or touch interactions suggest that contact in the home dominates, whereas more inclusive contact measures indicate that home and work settings may be of higher importance. In the absence of definitive knowledge of the contact required to facilitate transmission of various

  9. Reliable Change on Neuropsychological Tests in the Uniform Data Set.

    Science.gov (United States)

    Gavett, Brandon E; Ashendorf, Lee; Gurnani, Ashita S

    2015-08-01

    Longitudinal normative data obtained from a robust elderly sample (i.e., believed to be free from neurodegenerative disease) are sparse. The purpose of the present study was to develop reliable change indices (RCIs) that can assist with interpretation of test score changes relative to a healthy sample of older adults (ages 50+). Participants were 4217 individuals who completed at least three annual evaluations at one of 34 past and present Alzheimer's Disease Centers throughout the United States. All participants were diagnosed as cognitively normal at every study visit, which ranged from three to nine approximately annual evaluations. One-year RCIs were calculated for 11 neuropsychological variables in the Uniform Data Set by regressing follow-up test scores onto baseline test scores, age, education, visit number, post-baseline assessment interval, race, and sex in a linear mixed effects regression framework. In addition, the cumulative frequency distributions of raw score changes were examined to describe the base rates of test score changes. Baseline test score, age, education, and race were robust predictors of follow-up test scores across most tests. The effects of maturation (aging) were more pronounced on tests related to attention and executive functioning, whereas practice effects were more pronounced on tests of episodic and semantic memory. Interpretation of longitudinal changes on 11 cognitive test variables can be facilitated through the use of reliable change intervals and base rates of score changes in this robust sample of older adults. A Web-based calculator is provided to assist neuropsychologists with interpretation of longitudinal change. PMID:26234918

  10. Reliable change on neuropsychological tests in the Uniform Data Set

    Science.gov (United States)

    Gavett, Brandon E.; Ashendorf, Lee; Gurnani, Ashita S.

    2016-01-01

    Objective Longitudinal normative data obtained from a robust elderly sample (i.e., believed to be free from neurodegenerative disease) are sparse. The purpose of the present study was to develop reliable change indices (RCIs) that can assist with interpretation of test score changes relative to a healthy sample of older adults (ages 50+). Method Participants were 4217 individuals who completed at least 3 annual evaluations at one of 34 past and present Alzheimer’s Disease Centers throughout the United States. All participants were diagnosed as cognitively normal at every study visit, which ranged from three to nine approximately annual evaluations. One-year RCIs were calculated for 11 neuropsychological variables in the Uniform Data Set by regressing follow-up test scores onto baseline test scores, age, education, visit number, post-baseline assessment interval, race, and sex in a linear mixed effects regression framework. In addition, the cumulative frequency distributions of raw score changes were examined to describe the base rates of test score changes. Results Baseline test score, age, education, and race were robust predictors of follow-up test scores across most tests. The effects of maturation (aging) were more pronounced on tests related to attention and executive functioning, whereas practice effects were more pronounced on tests of episodic and semantic memory. Interpretation of longitudinal changes on 11 cognitive test variables can be facilitated through the use of reliable change intervals and base rates of score changes in this robust sample of older adults. A web-based calculator is provided to assist neuropsychologists with interpretation of longitudinal change. PMID:26234918

  11. Dengue transmission in the small-island setting: investigations from the Caribbean island of Grenada

    DEFF Research Database (Denmark)

    Schiøler, Karin Linda; Macpherson, Calum N

    2009-01-01

    The Caribbean region has experienced a major surge in dengue activity in recent decades. Yet, for many, and especially the smaller islands, the true extent and general epidemiology of dengue transmission remains unclear because of inadequate systems of surveillance and reporting. We established an...... benign dengue fever. A shift in serotype activity and modal age was evident during the noted transition, with the more densely populated south end of the island presenting the focus of transmission....

  12. In Situ Transmission Electron Microscopy Observation of Nanostructural Changes in Phase-Change Memory

    KAUST Repository

    Meister, Stefan

    2011-04-26

    Phase-change memory (PCM) has been researched extensively as a promising alternative to flash memory. Important studies have focused on its scalability, switching speed, endurance, and new materials. Still, reliability issues and inconsistent switching in PCM devices motivate the need to further study its fundamental properties. However, many investigations treat PCM cells as black boxes; nanostructural changes inside the devices remain hidden. Here, using in situ transmission electron microscopy, we observe real-time nanostructural changes in lateral Ge2Sb2Te5 (GST) PCM bridges during switching. We find that PCM devices with similar resistances can exhibit distinct threshold switching behaviors due to the different initial distribution of nanocrystalline and amorphous domains, explaining variability of switching behaviors of PCM cells in the literature. Our findings show a direct correlation between nanostructure and switching behavior, providing important guidelines in the design and operation of future PCM devices with improved endurance and lower variability. © 2011 American Chemical Society.

  13. Preventing Transmission of Zika Virus in Labor and Delivery Settings Through Implementation of Standard Precautions - United States, 2016.

    Science.gov (United States)

    Olson, Christine K; Iwamoto, Martha; Perkins, Kiran M; Polen, Kara N D; Hageman, Jeffrey; Meaney-Delman, Dana; Igbinosa, Irogue I; Khan, Sumaiya; Honein, Margaret A; Bell, Michael; Rasmussen, Sonja A; Jamieson, Denise J

    2016-01-01

    Zika virus transmission was detected in the Region of the Americas (Americas) in Brazil in May 2015, and as of March 21, 2016, local mosquito-borne transmission of Zika virus had been reported in 32 countries and territories in the Americas, including Puerto Rico and the U.S. Virgin Islands.* Most persons infected with Zika virus have a mild illness or are asymptomatic. However, increasing evidence supports a link between Zika virus infection during pregnancy and adverse pregnancy and birth outcomes (1), and a possible association between recent Zika virus infection and Guillain-Barré syndrome has been reported (2). Although Zika virus is primarily transmitted through the bite of Aedes species of mosquitoes, sexual transmission also has been documented (3). Zika virus RNA has been detected in a number of body fluids, including blood, urine, saliva, and amniotic fluid (3-5), and whereas transmission associated with occupational exposure to these body fluids is theoretically possible, it has not been documented. Although there are no reports of transmission of Zika virus from infected patients to health care personnel or other patients, minimizing exposures to body fluids is important to reduce the possibility of such transmission. CDC recommends Standard Precautions in all health care settings to protect both health care personnel and patients from infection with Zika virus as well as from blood-borne pathogens (e.g., human immunodeficiency virus [HIV] and hepatitis C virus [HCV]) (6). Because of the potential for exposure to large volumes of body fluids during the labor and delivery process and the sometimes unpredictable and fast-paced nature of obstetrical care, the use of Standard Precautions in these settings is essential to prevent possible transmission of Zika virus from patients to health care personnel. PMID:27010422

  14. Priority interventions to reduce HIV transmission in sex work settings in sub-Saharan Africa and delivery of these services

    Directory of Open Access Journals (Sweden)

    Matthew F Chersich

    2013-03-01

    Full Text Available Introduction: Virtually no African country provides HIV prevention services in sex work settings with an adequate scale and intensity. Uncertainty remains about the optimal set of interventions and mode of delivery. Methods: We systematically reviewed studies reporting interventions for reducing HIV transmission among female sex workers in sub-Saharan Africa between January 2000 and July 2011. Medline (PubMed and non-indexed journals were searched for studies with quantitative study outcomes. Results: We located 26 studies, including seven randomized trials. Evidence supports implementation of the following interventions to reduce unprotected sex among female sex workers: peer-mediated condom promotion, risk-reduction counselling and skills-building for safer sex. One study found that interventions to counter hazardous alcohol-use lowered unprotected sex. Data also show effectiveness of screening for sexually transmitted infections (STIs and syndromic STI treatment, but experience with periodic presumptive treatment is limited. HIV testing and counselling is essential for facilitating sex workers’ access to care and antiretroviral treatment (ART, but testing models for sex workers and indeed for ART access are little studied, as are structural interventions, which create conditions conducive for risk reduction. With the exception of Senegal, persistent criminalization of sex work across Africa reduces sex workers’ control over working conditions and impedes their access to health services. It also obstructs health-service provision and legal protection. Conclusions: There is sufficient evidence of effectiveness of targeted interventions with female sex workers in Africa to inform delivery of services for this population. With improved planning and political will, services – including peer interventions, condom promotion and STI screening – would act at multiple levels to reduce HIV exposure and transmission efficiency among sex workers

  15. Blood-borne virus transmission in healthcare settings in Ireland: review of patient notification exercises 1997-2011.

    LENUS (Irish Health Repository)

    Donohue, S

    2012-01-21

    A review of patient notification exercises (PNEs) carried out in Ireland between 1997 and 2011 to investigate potential exposure to blood-borne viruses (BBVs) in healthcare settings was undertaken to inform future policy and practice. A questionnaire was sent to key informants in the health services to identify all relevant PNEs. Structured interviews were conducted with key investigators, and available documentation was examined. Ten BBV-related PNEs were identified. Despite testing over 2000 patients, only one case of transmission was found. However, in-depth local investigations before undertaking the PNEs identified six cases of healthcare-associated transmission.

  16. Ultrafast optically induced transmission change of a high quality mirror

    International Nuclear Information System (INIS)

    Full text: The ultrafast response of a high-reflectivity GaAs/AlAs Bragg mirror to optical pumping is investigated for all-optical switching applications. Both Kerr and free carrier nonlinearities are induced with 100 fs, 780 nm pulses with a fluence of 0.64 kJ/m2 and 0.8 kJ/m2. The absolute transmission of the mirror at 931 nm increases by a factor of 27 from 0.0024 % to 0.065 % on a picosecond timescale. These results demonstrate the potential for a high-reflectivity ultrafast switchable mirror for quantum optics and optical communication applications. A design is proposed for a structure to be pumped below the bandgaps of the semiconductor mirror materials. Theoretical calculations on this structure show switching ratios up to 2200 corresponding to switching from 0.017 % to 37.4 % transmission. (author)

  17. Changes in parasite transmission stage excretion after pheasant release.

    Science.gov (United States)

    Villanúa, D; Acevedo, P; Höfle, U; Rodríguez, O; Gortázar, C

    2006-09-01

    The production of parasite transmission stages was investigated in the faeces of 77 farm-bred ring-necked pheasants (Phasianus colchicus). Coccidian oocysts (Eimeria sp.), and nematode eggs (Heterakis sp., and Capillaria-like eggs) were recovered before and after release but all birds were treated prior to release. Treatment with fenbendazole significantly reduced the abundance of transmission-stage excretion for all parasites, and reduced the prevalence in the case of Eimeria sp. and Heterakis sp. Nonetheless, a significant increase in the excretion abundance for all parasites and in the prevalence of Eimeria sp. and Heterakis sp. was found after release. Eggs of Ascaridia sp. were found only after releasing, suggesting infection ocurred in the wild. A negative relationship was found between the pheasant body condition and Heterakis excretion abundance and a higher abundance of Capillaria sp. eggs in female birds. No significant relationship was found between parasite excretion abundance and pheasant survival. Despite this, results suggest that an increase in the excretion of parasite transmission stages follows the release of captive pheasants into the wild. This can in part explain restocking failures, but also means that autochtonous free-living birds may become exposed to new and potentially harmful pathogens. To avoid these risks it is proposed that improved prophylactic measures should be taken. PMID:16923277

  18. Consideration of future climatic changes in three geologic settings

    International Nuclear Information System (INIS)

    Staff at Pacific Northwest Laboratory are evaluating the potential for climatic change to affect the integrity of a nuclear waste repository at: (1) the Gibson Dome area of Utah; (2) the Palo Duro Basin of Texas; and (3) the Gulf Coast. Because a major assumption in this analysis is that a glacial age will recur, the climate of the last glacial period is examined for each location. Combining these paleoclimatic data with the current climatic data, each location is evaluated in light of the criteria given in Draft Revised General Guidelines for Recommendation of Sites for Nuclear Waste Repositories (10 CFR 960). The results of this analysis suggest that sites located in these areas are likely to meet the climate requirements set forth in the guidelines. However, further study is needed before a definitive statement can be made. In particular, modeling the effect of sea level change on the Gulf Coast groundwater system and obtaining an improved estimation for the increase in recharge during glacier times at the Texas and Utah locations would be useful. Several stragegies are presented for accomplishing this work. 94 references, 27 figures, 5 tables

  19. Consideration of future climatic changes in three geologic settings

    Energy Technology Data Exchange (ETDEWEB)

    Petrie, G.M.

    1984-09-01

    Staff at Pacific Northwest Laboratory are evaluating the potential for climatic change to affect the integrity of a nuclear waste repository at: (1) the Gibson Dome area of Utah; (2) the Palo Duro Basin of Texas; and (3) the Gulf Coast. Because a major assumption in this analysis is that a glacial age will recur, the climate of the last glacial period is examined for each location. Combining these paleoclimatic data with the current climatic data, each location is evaluated in light of the criteria given in Draft Revised General Guidelines for Recommendation of Sites for Nuclear Waste Repositories (10 CFR 960). The results of this analysis suggest that sites located in these areas are likely to meet the climate requirements set forth in the guidelines. However, further study is needed before a definitive statement can be made. In particular, modeling the effect of sea level change on the Gulf Coast groundwater system and obtaining an improved estimation for the increase in recharge during glacier times at the Texas and Utah locations would be useful. Several stragegies are presented for accomplishing this work. 94 references, 27 figures, 5 tables.

  20. Design of Pinion Machine Tool-settings for Spiral Bevel Gears by Controlling Contact Path and Transmission Errors

    Institute of Scientific and Technical Information of China (English)

    Cao Xuemei; Fang Zongde; Xu Hao; Su Jinzhan

    2008-01-01

    This paper proposes a new approach to design pinion machine tool-settings for spiral bevel gears by controlling contact path and transmis- sion errors. It is based on the satisfaction of contact condition of three given control points on the tooth surface. The three meshing points are controlled to be on a predesigned straight contact path that meets the pre-designed parabolic function of transmission errors. Designed separately, the magnitude of transmission errors and the orientation of the contact path are subjected to precise control. In addition, in order to meet the manufacturing requirements, we suggest to modify the values of blank offset, one of the pinion machine tool-settings, and redesign pinion ma- chine tool-settings to ensure that the magnitude and the geometry of transmission errors should not be influenced apart from minor effects on the predesigned straight contact path. The proposed approach together with its ideas has been proven by a numerical example and the manufacturing practice of a pair of spiral bevel gears.

  1. How Settings Change People: Applying Behavior Setting Theory to Consumer-Run Organizations

    Science.gov (United States)

    Brown, Louis D.; Shepherd, Matthew D.; Wituk, Scott A.; Meissen, Greg

    2007-01-01

    Self-help initiatives stand as a classic context for organizational studies in community psychology. Behavior setting theory stands as a classic conception of organizations and the environment. This study explores both, applying behavior setting theory to consumer-run organizations (CROs). Analysis of multiple data sets from all CROs in Kansas…

  2. Transmission Intensity and Drug Resistance in Malaria Population Dynamics : Implications for Climate Change

    NARCIS (Netherlands)

    Artzy-Randrup, Yael; Alonso, David; Pascual, Mercedes

    2010-01-01

    Although the spread of drug resistance and the influence of climate change on malaria are most often considered separately, these factors have the potential to interact through altered levels of transmission intensity. The influence of transmission intensity on the evolution of drug resistance has b

  3. Transmission of HIV, hepatitis B virus, and other bloodborne pathogens in health care settings: a review of risk factors and guidelines for prevention. World Health Organization.

    OpenAIRE

    Hu, D. J.; Kane, M A; Heymann, D.L.

    1991-01-01

    Recent reports of the transmission of human immunodeficiency virus (HIV) in health care settings have caused considerable public health concern. HIV as well as hepatitis B virus (HBV) and other bloodborne pathogens do constitute infectious hazards in certain settings. Transmission has been reported from patient to patient, patient to health care workers, and rarely, from health care worker to patient. Although the risk of bloodborne pathogen transmission is largely preventable, it may occur d...

  4. HIV transmission in the dental setting and the HIV-infected oral health care professional: workshop 1C.

    LENUS (Irish Health Repository)

    Flint, S R

    2011-04-01

    This workshop addressed two important issues: first, the global evidence of HIV transmission from health care provider to patient and from patient to health care provider in the general health care environment and the dental practice setting; second, in the era of highly active antiretroviral therapy, whether oral health care professionals living with HIV pose a risk of transmission to their patients and whether standard infection control is adequate to protect both the patient and the oral health care professional in dental practice. The workshop culminated in a general discussion and the formulation of a consensus statement from the participating delegates, representing more than 30 countries, on the criteria under which an HIV-infected oral health care professional might practice dentistry without putting patients at risk. This consensus statement, the Beijing Declaration, was agreed nem con.

  5. Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: the possible role of dry surface contamination.

    Science.gov (United States)

    Otter, J A; Donskey, C; Yezli, S; Douthwaite, S; Goldenberg, S D; Weber, D J

    2016-03-01

    Viruses with pandemic potential including H1N1, H5N1, and H5N7 influenza viruses, and severe acute respiratory syndrome (SARS)/Middle East respiratory syndrome (MERS) coronaviruses (CoV) have emerged in recent years. SARS-CoV, MERS-CoV, and influenza virus can survive on surfaces for extended periods, sometimes up to months. Factors influencing the survival of these viruses on surfaces include: strain variation, titre, surface type, suspending medium, mode of deposition, temperature and relative humidity, and the method used to determine the viability of the virus. Environmental sampling has identified contamination in field-settings with SARS-CoV and influenza virus, although the frequent use of molecular detection methods may not necessarily represent the presence of viable virus. The importance of indirect contact transmission (involving contamination of inanimate surfaces) is uncertain compared with other transmission routes, principally direct contact transmission (independent of surface contamination), droplet, and airborne routes. However, influenza virus and SARS-CoV may be shed into the environment and be transferred from environmental surfaces to hands of patients and healthcare providers. Emerging data suggest that MERS-CoV also shares these properties. Once contaminated from the environment, hands can then initiate self-inoculation of mucous membranes of the nose, eyes or mouth. Mathematical and animal models, and intervention studies suggest that contact transmission is the most important route in some scenarios. Infection prevention and control implications include the need for hand hygiene and personal protective equipment to minimize self-contamination and to protect against inoculation of mucosal surfaces and the respiratory tract, and enhanced surface cleaning and disinfection in healthcare settings. PMID:26597631

  6. A model for initiating change in the dialysis setting.

    Science.gov (United States)

    Gomez, Norma J; Martin-Lester, Melinda J

    2012-10-01

    Implementing a significant change in an organization is one of the most challenging endeavors that faces a manager. If the change involves the establishment of new paradigms that will replace the existing ways of doing business, the challenge is particularly daunting. Change theory is a process that can be used to facilitate change in an organization. It provides a guide for the manager to follow in attaining a desired outcome. Several change theorists and their works are discussed. An example is provided using change theory to identify strategies for delivering a medication once per month from once a treatment. PMID:23427716

  7. Predicted impacts of climate change on malaria transmission in West Africa

    Science.gov (United States)

    Yamana, T. K.; Eltahir, E. A. B.

    2014-12-01

    Increases in temperature and changes in precipitation due to climate change are expected to alter the spatial distribution of malaria transmission. This is especially true in West Africa, where malaria prevalence follows the current north-south gradients in temperature and precipitation. We assess the skill of GCMs at simulating past and present climate in West Africa in order to select the most credible climate predictions for the periods 2030-2060 and 2070-2100. We then use the Hydrology, Entomology and Malaria Transmission Simulator (HYDREMATS), a mechanistic model of malaria transmission, to translate the predicted changes in climate into predicted changes availability of mosquito breeding sites, mosquito populations, and malaria prevalence. We investigate the role of acquired immunity in determining a population's response to changes in exposure to the malaria parasite.

  8. The Response of Environmental Capacity for Malaria Transmission in West Africa to Climate Change

    Science.gov (United States)

    Yamana, T. K.; Eltahir, E. A.

    2011-12-01

    The climate of West Africa is characterized by north-south gradients in temperature and rainfall. Environmental capacity for malaria transmission (e.g. as measured by vectorial capacity) is strongly tied to these two variables; temperature affects the development rate of the malaria parasite, as well as the lifespan of the mosquitoes that transmit the disease, and rainfall is tied to mosquito abundance, as the vector lays its eggs in rain-fed water pools. A change in climate is therefore expected to lead to changes in the distribution of malaria transmission. Current general circulation models agree that the temperature in West Africa is expected to increase by several degrees in the next century. However they predict a wide range of possible rainfall scenarios in the future, from intense drying to significant increases in rainfall (Christensen et al., 2007). The effects these changes will have on environmental capacity for malaria transmission depend on the magnitude and direction of the changes, and on current conditions. For example, malaria transmission will be more sensitive to positive changes in rainfall in dry areas where mosquito populations are currently limited by water availability than in relatively wet areas. Here, we analyze combinations of changes in rainfall and temperature within the ranges predicted by GCMs, and assess the impact these combinations will have on the environmental capacity for malaria transmission. In particular, we identify climate change scenarios that are likely to have the greatest impact on environmental capacity for malaria transmission, as well as geographic "hot spots" where the greatest changes are to be expected. Christensen, J. H., Busuioc, A., & et al. (2007). Regional climate projections. In S. Solomon (Ed.), Climate change 2007: The physical science basis. Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change.

  9. Strategies for controlling non-transmissible infection outbreaks using a large human movement data set.

    Directory of Open Access Journals (Sweden)

    Penelope A Hancock

    2014-09-01

    Full Text Available Prediction and control of the spread of infectious disease in human populations benefits greatly from our growing capacity to quantify human movement behavior. Here we develop a mathematical model for non-transmissible infections contracted from a localized environmental source, informed by a detailed description of movement patterns of the population of Great Britain. The model is applied to outbreaks of Legionnaires' disease, a potentially life-threatening form of pneumonia caused by the bacteria Legionella pneumophilia. We use case-report data from three recent outbreaks that have occurred in Great Britain where the source has already been identified by public health agencies. We first demonstrate that the amount of individual-level heterogeneity incorporated in the movement data greatly influences our ability to predict the source location. The most accurate predictions were obtained using reported travel histories to describe movements of infected individuals, but using detailed simulation models to estimate movement patterns offers an effective fast alternative. Secondly, once the source is identified, we show that our model can be used to accurately determine the population likely to have been exposed to the pathogen, and hence predict the residential locations of infected individuals. The results give rise to an effective control strategy that can be implemented rapidly in response to an outbreak.

  10. Revealing the Micro-scale Signature of Endemic Zoonotic Disease Transmission in an African Urban Setting

    Science.gov (United States)

    Bourhy, Hervé; Nakouné, Emmanuel; Hall, Matthew; Nouvellet, Pierre; Lepelletier, Anthony; Talbi, Chiraz; Watier, Laurence; Holmes, Edward C.; Cauchemez, Simon; Lemey, Philippe; Donnelly, Christl A.; Rambaut, Andrew

    2016-01-01

    The development of novel approaches that combine epidemiological and genomic data provides new opportunities to reveal the spatiotemporal dynamics of infectious diseases and determine the processes responsible for their spread and maintenance. Taking advantage of detailed epidemiological time series and viral sequence data from more than 20 years reported by the National Reference Centre for Rabies of Bangui, the capital city of Central African Republic, we used a combination of mathematical modeling and phylogenetic analysis to determine the spatiotemporal dynamics of rabies in domestic dogs as well as the frequency of extinction and introduction events in an African city. We show that although dog rabies virus (RABV) appears to be endemic in Bangui, its epidemiology is in fact shaped by the regular extinction of local chains of transmission coupled with the introduction of new lineages, generating successive waves of spread. Notably, the effective reproduction number during each wave was rarely above the critical value of 1, such that rabies is not self-sustaining in Bangui. In turn, this suggests that rabies at local geographic scales is driven by human-mediated dispersal of RABV among sparsely connected peri-urban and rural areas as opposed to dispersion in a relatively large homogenous urban dog population. This combined epidemiological and genomic approach enables development of a comprehensive framework for understanding disease persistence and informing control measures, indicating that control measures are probably best targeted towards areas neighbouring the city that appear as the source of frequent incursions seeding outbreaks in Bangui. PMID:27058957

  11. The dependence of the abstract boundary classification on a set of curves II: How the classification changes when the bounded parameter property satisfying set of curves changes

    CERN Document Server

    Whale, B E

    2012-01-01

    The abstract boundary uses sets of curves with the bounded parameter property (b.p.p.) to classify the elements of the abstract boundary into regular points, singular points, points at infinity and so on. Building on the material of Part one of this two part series, we show how this classification changes when the set of b.p.p. satisfying curves changes.

  12. Secondary mapping of lymphatic filariasis in Haiti-definition of transmission foci in low-prevalence settings.

    Directory of Open Access Journals (Sweden)

    Naomi Drexler

    Full Text Available To eliminate Lymphatic filariasis (LF as a public health problem, the World Health Organization (WHO recommends that any area with infection prevalence greater than or equal to 1% (denoted by presence of microfilaremia or antigenemia should receive mass drug administration (MDA of antifilarial drugs for at least five consecutive rounds. Areas of low-antigen prevalence (< 1% are thought to pose little risk for continued transmission of LF. Five low-antigen prevalence communes in Haiti, characterized as part of a national survey, were further assessed for transmission in this study. An initial evaluation of schoolchildren was performed in each commune to identify antigen-positive children who served as index cases for subsequent community surveys conducted among households neighboring the index cases. Global positioning system (GPS coordinates and immunochromatographic tests (ICT for filarial antigenemia were collected on approximately 1,600 persons of all ages in the five communes. The relationship between antigen-positive cases in the community and distance from index cases was evaluated using multivariate regression techniques and analyses of spatial clustering. Community surveys demonstrated higher antigen prevalence in three of the five communes than was observed in the original mapping survey; autochthonous cases were found in the same three communes. Regression techniques identified a significantly increased likelihood of being antigen-positive when living within 20 meters of index cases when controlling for age, gender, and commune. Spatial clustering of antigen-positive cases was observed in some, but not all communes. Our results suggest that localized transmission was present even in low-prevalence settings and suggest that better surveillance methods may be needed to detect microfoci of LF transmission.

  13. Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting

    Directory of Open Access Journals (Sweden)

    Iukary Takenami

    2012-01-01

    Full Text Available Objectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a follow-up examination. The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared. Results. Of the 26 study participants, 25 (96% showed an IFN-γ level higher than their baseline level before treatment (P≤0.001. Only one individual had a decreased IFN-γ level after treatment but remained positive for LTBI. Conclusion. In a high-transmission setting, the IFN-γ level has increased after LTBI treatment. Further studies must be undertaken to understand if this elevation is transient.

  14. Long-term effects of penicillin resistance and fitness cost on pneumococcal transmission dynamics in a developed setting

    Directory of Open Access Journals (Sweden)

    Diana Tilevik

    2016-05-01

    Full Text Available Background: The increasing prevalence of penicillin non-susceptible pneumococci (PNSP throughout the world threatens successful treatment of infections caused by this important bacterial pathogen. The rate at which PNSP clones spread in the community is thought to mainly be determined by two key determinants; the volume of penicillin use and the magnitude of the fitness cost in the absence of treatment. The aim of the study was to determine the impacts of penicillin consumption and fitness cost on pneumococcal transmission dynamics in a developed country setting. Methods: An individual-based network model based on real-life demographic data was constructed and applied in a developed country setting (Sweden. A population structure with transmission of carriage taking place within relevant mixing groups, i.e. families, day care groups, school classes, and other close contacts, was considered to properly assess the transmission dynamics for susceptible and PNSP clones. Several scenarios were simulated and model outcomes were statistically analysed. Results: Model simulations predicted that with an outpatient penicillin use corresponding to the sales in Sweden 2010 (118 recipes per 1,000 inhabitants per year, the magnitude of a fitness cost for resistance must be at least 5% to offset the advantage of penicillin resistance. Moreover, even if there is a fitness cost associated with penicillin resistance, a considerable reduction of penicillin usage appears to be required to significantly decrease the incidence of PNSP in a community. Conclusion: The frequency of PNSP clones is hard to reverse by simply reducing the penicillin consumption even if there is a biological cost associated with resistance. However, because penicillin usage does promote further spread of PNSP clones, it is important to keep down penicillin consumption considering future resistance problems.

  15. Transmission of Middle East Respiratory Syndrome Coronavirus Infections in Healthcare Settings, Abu Dhabi

    Science.gov (United States)

    Nguyen, Duc; Aden, Bashir; Al Bandar, Zyad; Al Dhaheri, Wafa; Abu Elkheir, Kheir; Khudair, Ahmed; Al Mulla, Mariam; El Saleh, Feda; Imambaccus, Hala; Al Kaabi, Nawal; Sheikh, Farrukh Amin; Sasse, Jurgen; Turner, Andrew; Abdel Wareth, Laila; Weber, Stefan; Al Ameri, Asma; Abu Amer, Wesal; Alami, Negar N.; Bunga, Sudhir; Haynes, Lia M.; Hall, Aron J.; Kallen, Alexander J.; Kuhar, David; Pham, Huong; Pringle, Kimberly; Tong, Suxiang; Whitaker, Brett L.; Gerber, Susan I.; Al Hosani, Farida Ismail

    2016-01-01

    Middle East respiratory syndrome coronavirus (MERS-CoV) infections sharply increased in the Arabian Peninsula during spring 2014. In Abu Dhabi, United Arab Emirates, these infections occurred primarily among healthcare workers and patients. To identify and describe epidemiologic and clinical characteristics of persons with healthcare-associated infection, we reviewed laboratory-confirmed MERS-CoV cases reported to the Health Authority of Abu Dhabi during January 1, 2013–May 9, 2014. Of 65 case-patients identified with MERS-CoV infection, 27 (42%) had healthcare-associated cases. Epidemiologic and genetic sequencing findings suggest that 3 healthcare clusters of MERS-CoV infection occurred, including 1 that resulted in 20 infected persons in 1 hospital. MERS-CoV in healthcare settings spread predominantly before MERS-CoV infection was diagnosed, underscoring the importance of increasing awareness and infection control measures at first points of entry to healthcare facilities. PMID:26981708

  16. Evaluation of 4 weeks' neonatal antiretroviral prophylaxis as a component of a prevention of mother-to-child transmission program in a resource-rich setting.

    LENUS (Irish Health Repository)

    Ferguson, Wendy

    2011-05-01

    In resource-rich settings, universal adoption of a 4- rather than 6-week neonatal antiretroviral (ARV) prophylaxis regimen could reduce toxicity and results in cost savings, provided prevention of mother-to-child transmission program effectiveness is not compromised.

  17. Secondary mapping of lymphatic filariasis in Haiti-definition of transmission foci in low-prevalence settings.

    Science.gov (United States)

    Drexler, Naomi; Washington, Charles H; Lovegrove, Maribeth; Grady, Caroline; Milord, Marie Denise; Streit, Thomas; Lammie, Patrick

    2012-01-01

    To eliminate Lymphatic filariasis (LF) as a public health problem, the World Health Organization (WHO) recommends that any area with infection prevalence greater than or equal to 1% (denoted by presence of microfilaremia or antigenemia) should receive mass drug administration (MDA) of antifilarial drugs for at least five consecutive rounds. Areas of low-antigen prevalence (children who served as index cases for subsequent community surveys conducted among households neighboring the index cases. Global positioning system (GPS) coordinates and immunochromatographic tests (ICT) for filarial antigenemia were collected on approximately 1,600 persons of all ages in the five communes. The relationship between antigen-positive cases in the community and distance from index cases was evaluated using multivariate regression techniques and analyses of spatial clustering. Community surveys demonstrated higher antigen prevalence in three of the five communes than was observed in the original mapping survey; autochthonous cases were found in the same three communes. Regression techniques identified a significantly increased likelihood of being antigen-positive when living within 20 meters of index cases when controlling for age, gender, and commune. Spatial clustering of antigen-positive cases was observed in some, but not all communes. Our results suggest that localized transmission was present even in low-prevalence settings and suggest that better surveillance methods may be needed to detect microfoci of LF transmission. PMID:23071849

  18. A Documentary Analysis of the Use of Leadership and Change Theory in Changing Practice in Early Years Settings

    Science.gov (United States)

    Davis, Geraldine

    2012-01-01

    Early years professionals wrote about changes in their settings as part of their MA studies, and reflected on the use of theories of leadership in implementing these changes. This article describes a documentary analysis of the scripts produced. Initially basing the study in current knowledge of leadership and change in Early Years settings, the…

  19. Setting priorities for land management to mitigate climate change

    Directory of Open Access Journals (Sweden)

    Böttcher Hannes

    2012-03-01

    Full Text Available Abstract Background No consensus has been reached how to measure the effectiveness of climate change mitigation in the land-use sector and how to prioritize land use accordingly. We used the long-term cumulative and average sectorial C stocks in biomass, soil and products, C stock changes, the substitution of fossil energy and of energy-intensive products, and net present value (NPV as evaluation criteria for the effectiveness of a hectare of productive land to mitigate climate change and produce economic returns. We evaluated land management options using real-life data of Thuringia, a region representative for central-western European conditions, and input from life cycle assessment, with a carbon-tracking model. We focused on solid biomass use for energy production. Results In forestry, the traditional timber production was most economically viable and most climate-friendly due to an assumed recycling rate of 80% of wood products for bioenergy. Intensification towards "pure bioenergy production" would reduce the average sectorial C stocks and the C substitution and would turn NPV negative. In the forest conservation (non-use option, the sectorial C stocks increased by 52% against timber production, which was not compensated by foregone wood products and C substitution. Among the cropland options wheat for food with straw use for energy, whole cereals for energy, and short rotation coppice for bioenergy the latter was most climate-friendly. However, specific subsidies or incentives for perennials would be needed to favour this option. Conclusions When using the harvested products as materials prior to energy use there is no climate argument to support intensification by switching from sawn-wood timber production towards energy-wood in forestry systems. A legal framework would be needed to ensure that harvested products are first used for raw materials prior to energy use. Only an effective recycling of biomaterials frees land for long

  20. Community-Associated Methicillin Resistant Staphylococcus aureus Transmission among Households of Infected Cases: a Pooled Analysis of Primary Data from Three Studies across International Settings

    Science.gov (United States)

    Knox, J.; Van Rijen, M.; Uhlemann, A.-C.; Miller, M.; Hafer, C.; Vavagiakis, P.; Shi, Q.; Johnson, P. D. R.; Coombs, G.; Van Den Bergh, M. Kluytmans; Kluytmans, J.; Bennett, C. M.; Lowy, F. D.

    2016-01-01

    SUMMARY Diverse strain types of methicillin resistant Staphylococcus aureus (MRSA) cause infections in community settings worldwide. To examine heterogeneity of spread within households and to identify common risk factors for household transmission across settings, primary data from studies conducted in New York, US, Breda, NL, and Melbourne, AU were pooled. Following MRSA infection of the index patient, household members completed questionnaires and provided nasal swabs. Swabs positive for S. aureus were genotyped by spa-sequencing. Poisson regression with robust error variance was used to estimate prevalence odds ratios for transmission of the clinical isolate to non-index household members. Great diversity of strain types existed across studies. Despite differences between studies, the index patient being colonized with the clinical isolate at the home visit (p<.01) and the percent of household members <18 years (p<.01) were independently associated with transmission. Targeted decolonization strategies could be used across geographic settings to limit household MRSA transmission. PMID:24763185

  1. Changes in Variable Number of Tandem Repeats in ‘Candidatus Liberibacter asiaticus’ through Insect Transmission

    Science.gov (United States)

    2015-01-01

    Citrus greening (huanglongbing) is the most destructive citrus disease worldwide. The disease is associated with three species of ‘Candidatus Liberibacter’ among which ‘Ca. Liberibacter asiaticus’ has the widest distribution. ‘Ca. L. asiaticus’ is commonly transmitted by a phloem-feeding insect vector, the Asian citrus psyllid Diaphorina citri. A previous study showed that isolates of ‘Ca. L. asiaticus’ were clearly differentiated by variable number of tandem repeat (VNTR) profiles at four loci in the genome. In this study, the VNTR analysis was further validated by assessing the stability of these repeats after multiplication of the pathogen upon host-to-host transmission using a ‘Ca. L. asiaticus’ strain from Japan. The results showed that some tandem repeats showed detectable changes after insect transmission. To our knowledge, this is the first report to demonstrate that the repeat numbers VNTR 002 and 077 of ‘Ca. L. asiaticus’ change through psyllid transmission. VNTRs in the recipient plant were apparently unrelated to the growing phase of the vector. In contrast, changes in the number of tandem repeats increased with longer acquisition and inoculation access periods, whereas changes were not observed through psyllid transmission after relatively short acquisition and inoculation access periods, up to 20 and 19 days, respectively. PMID:26402645

  2. The role of climate variability and change in the transmission dynamics and geographic distribution of dengue

    NARCIS (Netherlands)

    K.T.D. Thai; K.L. Anders

    2011-01-01

    The mounting evidence for anthropogenic changes in global climate raises many pressing questions about the potential effects on biological systems, and in particular the transmission of infectious diseases. Vector-borne diseases, such as dengue, may be particularly sensitive to both periodic fluctua

  3. Changes in Variable Number of Tandem Repeats in 'Candidatus Liberibacter asiaticus' through Insect Transmission.

    Directory of Open Access Journals (Sweden)

    Hiroshi Katoh

    Full Text Available Citrus greening (huanglongbing is the most destructive citrus disease worldwide. The disease is associated with three species of 'Candidatus Liberibacter' among which 'Ca. Liberibacter asiaticus' has the widest distribution. 'Ca. L. asiaticus' is commonly transmitted by a phloem-feeding insect vector, the Asian citrus psyllid Diaphorina citri. A previous study showed that isolates of 'Ca. L. asiaticus' were clearly differentiated by variable number of tandem repeat (VNTR profiles at four loci in the genome. In this study, the VNTR analysis was further validated by assessing the stability of these repeats after multiplication of the pathogen upon host-to-host transmission using a 'Ca. L. asiaticus' strain from Japan. The results showed that some tandem repeats showed detectable changes after insect transmission. To our knowledge, this is the first report to demonstrate that the repeat numbers VNTR 002 and 077 of 'Ca. L. asiaticus' change through psyllid transmission. VNTRs in the recipient plant were apparently unrelated to the growing phase of the vector. In contrast, changes in the number of tandem repeats increased with longer acquisition and inoculation access periods, whereas changes were not observed through psyllid transmission after relatively short acquisition and inoculation access periods, up to 20 and 19 days, respectively.

  4. Impact of global climate change on transmissivity of shallow hard-rock aquifers

    Czech Academy of Sciences Publication Activity Database

    Hrkal, Z.; Kobr, M.; Nedvědová, E.; Tesař, Miroslav; Vilhelm, Z.

    Wroclav : Wydawnictwo Uniwersytetu Wroclawskiego, 2007 - (Marszalek, H.; Chudy, K.), s. 191-203 ISBN 978-83-229-2912-4 Grant ostatní: GA ČR(CZ) GA205/05/0177 Institutional research plan: CEZ:AV0Z20600510 Keywords : climate change * transmissivity * hard-rock aquifer Subject RIV: DA - Hydrology ; Limnology

  5. Changes in Variable Number of Tandem Repeats in 'Candidatus Liberibacter asiaticus' through Insect Transmission.

    Science.gov (United States)

    Katoh, Hiroshi; Inoue, Hiromitsu; Iwanami, Toru

    2015-01-01

    Citrus greening (huanglongbing) is the most destructive citrus disease worldwide. The disease is associated with three species of 'Candidatus Liberibacter' among which 'Ca. Liberibacter asiaticus' has the widest distribution. 'Ca. L. asiaticus' is commonly transmitted by a phloem-feeding insect vector, the Asian citrus psyllid Diaphorina citri. A previous study showed that isolates of 'Ca. L. asiaticus' were clearly differentiated by variable number of tandem repeat (VNTR) profiles at four loci in the genome. In this study, the VNTR analysis was further validated by assessing the stability of these repeats after multiplication of the pathogen upon host-to-host transmission using a 'Ca. L. asiaticus' strain from Japan. The results showed that some tandem repeats showed detectable changes after insect transmission. To our knowledge, this is the first report to demonstrate that the repeat numbers VNTR 002 and 077 of 'Ca. L. asiaticus' change through psyllid transmission. VNTRs in the recipient plant were apparently unrelated to the growing phase of the vector. In contrast, changes in the number of tandem repeats increased with longer acquisition and inoculation access periods, whereas changes were not observed through psyllid transmission after relatively short acquisition and inoculation access periods, up to 20 and 19 days, respectively. PMID:26402645

  6. Vancomycin-resistant enterococci in intensive-care hospital settings: Transmission dynamics, persistence, and the impact of infection control programs

    OpenAIRE

    Daren J Austin; Bonten, Marc J.M.; Weinstein, Robert A; Slaughter, Sarah; Roy M Anderson

    1999-01-01

    Vancomycin-resistant enterococci (VRE) recently have emerged as a nosocomial pathogen especially in intensive-care units (ICUs) worldwide. Transmission via the hands of health-care workers is an important determinant of spread and persistence in a VRE-endemic ICU. We describe the transmission of nosocomial pathogens by using a micro-epidemiological framework based on the transmission dynamics of vector-borne diseases. By using the concept of a basic reproductive number, R0, defined as the ave...

  7. Estimating Plasmodium falciparum Transmission Rates in Low-Endemic Settings Using a Combination of Community Prevalence and Health Facility Data

    OpenAIRE

    Joshua Yukich; Olivier Briët; Bretscher, Michael T.; Adam Bennett; Seblewengel Lemma; Yemane Berhane; Eisele, Thomas P; Joseph Keating; Thomas Smith

    2012-01-01

    As some malaria control programs shift focus from disease control to transmission reduction, there is a need for transmission data to monitor progress. At lower levels of transmission, it becomes increasingly more difficult to measure precisely, for example through entomological studies. Many programs conduct regular cross sectional parasite prevalence surveys, and have access to malaria treatment data routinely collected by ministries of health, often in health management information systems...

  8. Community-based approaches for prevention of mother to child transmission in resource-poor settings: a social ecological review

    Directory of Open Access Journals (Sweden)

    Leila Katirayi

    2012-07-01

    Full Text Available Introduction: Numerous barriers to optimal uptake of prevention of mother to child transmission (PMTCT services occur at community level (i.e., outside the healthcare setting. To achieve elimination of paediatric HIV, therefore, interventions must also work within communities to address these barriers and increase service use and need to be informed by evidence. This paper reviews community-based approaches that have been used in resource-limited settings to increase rates of PMTCT enrolment, retention in care and successful treatment outcomes. It aims to identify which interventions work, why they may do so and what knowledge gaps remain. Methods: First, we identified barriers to PMTCT that originate outside the health system. These were used to construct a social ecological framework categorizing barriers to PMTCT into the following levels of influence: individual, peer and family, community and sociocultural. We then used this conceptual framework to guide a review of the literature on community-based approaches, defined as interventions delivered outside of formal health settings, with the goal of increasing uptake, retention, adherence and positive psychosocial outcomes in PMTCT programmes in resource-poor countries. Results: Our review found evidence of effectiveness of strategies targeting individuals and peer/family levels (e.g., providing household HIV testing and training peer counsellors to support exclusive breastfeeding and at community level (e.g., participatory women's groups and home-based care to support adherence and retention. Evidence is more limited for complex interventions combining multiple strategies across different ecological levels. There is often little information describing implementation; and approaches such as “community mobilization” remain poorly defined. Conclusions: Evidence from existing community approaches can be adapted for use in planning PMTCT. However, for successful replication of evidence

  9. Climate change impacts on West Nile virus transmission in a global context.

    Science.gov (United States)

    Paz, Shlomit

    2015-04-01

    West Nile virus (WNV), the most widely distributed virus of the encephalitic flaviviruses, is a vector-borne pathogen of global importance. The transmission cycle exists in rural and urban areas where the virus infects birds, humans, horses and other mammals. Multiple factors impact the transmission and distribution of WNV, related to the dynamics and interactions between pathogen, vector, vertebrate hosts and environment. Hence, among other drivers, weather conditions have direct and indirect influences on vector competence (the ability to acquire, maintain and transmit the virus), on the vector population dynamic and on the virus replication rate within the mosquito, which are mostly weather dependent. The importance of climatic factors (temperature, precipitation, relative humidity and winds) as drivers in WNV epidemiology is increasing under conditions of climate change. Indeed, recent changes in climatic conditions, particularly increased ambient temperature and fluctuations in rainfall amounts, contributed to the maintenance (endemization process) of WNV in various locations in southern Europe, western Asia, the eastern Mediterranean, the Canadian Prairies, parts of the USA and Australia. As predictions show that the current trends are expected to continue, for better preparedness, any assessment of future transmission of WNV should take into consideration the impacts of climate change. PMID:25688020

  10. Changing malaria epidemiology in four urban settings in sub-Saharan Africa

    OpenAIRE

    Wang, Shr-Jie Sharlenna

    2005-01-01

    Background An estimated 200 million persons in sub-Saharan Africa (SSA) live currently in urban centres in malaria endemic areas. The epidemiology and control of urban malaria poses a number of specific challenges in comparison to rural areas, most notably the heterogeneous spatial distribution of transmission and the low state of immunity in the population. Interestingly, much less is currently known about malaria in urban settings than in rural areas. As a result there is an ...

  11. Changing Malaria Epidemiology in Four Urban Settings in Sub-Saharan Africa

    OpenAIRE

    Wang, Shr-Jie Sharlenna

    2005-01-01

    Background An estimated 200 million persons in sub-Saharan Africa (SSA) live currently in urban centres in malaria endemic areas. The epidemiology and control of urban malaria poses a number of specific challenges in comparison to rural areas, most notably the heterogeneous spatial distribution of transmission and the low state of immunity in the population. Interestingly, much less is currently known about malaria in urban settings than in rural areas. As a result there is an essential need ...

  12. Underwater asymmetric acoustic transmission structure using the medium with gradient change of impedance

    Science.gov (United States)

    Bo, Hu; Jie, Shi; Sheng-Guo, Shi; Yu, Sun; Zhong-Rui, Zhu

    2016-02-01

    We propose an underwater asymmetric acoustic transmission structure comprised of two media each with a gradient change of acoustic impedance. By gradually increasing the acoustic impedances of the media, the propagating direction of the acoustic wave can be continuously bent, resulting in allowing the acoustic wave to pass through along the positive direction and blocking acoustic waves from the negative one. The main advantages of this structure are that the asymmetric transmission effect of this structure can be realized and enhanced more easily in water. We investigate both numerically and experimentally the asymmetric transmission effect. The experimental results show that a highly efficient asymmetric acoustic transmission can be yielded within a remarkable broadband frequency range, which agrees well with the numerical prediction. It is of potential practical significance for various underwater applications such as reducing vibration and noise. Project supported by the National Natural Science Foundation of China (Grant Nos. 11204049 and 11204050), the Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China (Grant No. IRT1228), and the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant Nos. 20122304120023 and 20122304120011).

  13. Determinants of the accuracy of rapid diagnostic tests in malaria case management: evidence from low and moderate transmission settings in the East African highlands

    Directory of Open Access Journals (Sweden)

    Rapuoda Beth

    2008-10-01

    Full Text Available Abstract Background The accuracy of malaria diagnosis has received renewed interest in recent years due to changes in treatment policies in favour of relatively high-cost artemisinin-based combination therapies. The use of rapid diagnostic tests (RDTs based on histidine-rich protein 2 (HRP2 synthesized by Plasmodium falciparum has been widely advocated to save costs and to minimize inappropriate treatment of non-malarial febrile illnesses. HRP2-based RDTs are highly sensitive and stable; however, their specificity is a cause for concern, particularly in areas of intense malaria transmission due to persistence of HRP2 antigens from previous infections. Methods In this study, 78,454 clinically diagnosed malaria patients were tested using HRP2-based RDTs over a period of approximately four years in four highland sites in Kenya and Uganda representing hypoendemic to mesoendemic settings. In addition, the utility of the tests was evaluated in comparison with expert microscopy for disease management in 2,241 subjects in two sites with different endemicity levels over four months. Results RDT positivity rates varied by season and year, indicating temporal changes in accuracy of clinical diagnosis. Compared to expert microscopy, the sensitivity, specificity, positive predictive value and negative predictive value of the RDTs in a hypoendemic site were 90.0%, 99.9%, 90.0% and 99.9%, respectively. Corresponding measures at a mesoendemic site were 91.0%, 65.0%, 71.6% and 88.1%. Although sensitivities at the two sites were broadly comparable, levels of specificity varied considerably between the sites as well as according to month of test, age of patient, and presence or absence of fever during consultation. Specificity was relatively high in older age groups and increased towards the end of the transmission season, indicating the role played by anti-HRP2 antibodies. Patients with high parasite densities were more likely to test positive with RDTs than

  14. Prevention of Parent to Child Transmission (PPTCT program data in India: an emerging data set for appraising the HIV epidemic.

    Directory of Open Access Journals (Sweden)

    Sema K Sgaier

    Full Text Available BACKGROUND: Evidence based resource allocation and decentralized planning of an effective HIV/AIDS response requires reliable information on levels and trends of HIV at national and sub-national geographic levels. HIV sentinel surveillance data from antenatal clinics (HSS-ANC has been an important data source to assess the HIV/AIDS epidemic in India, but has a number of limitations. We assess the value of Prevention of Parent to Child Transmission (PPTCT programme data to appraise the HIV epidemic in India. METHODS/FINDINGS: HIV data from PPTCT sites were compared to HSS-ANC and general population level surveys at various geographic levels in the states of Karnataka, Maharashtra and Andhra Pradesh. Chi-square tests were used to ascertain statistical significance. PPTCT HIV prevalence was significantly lower than HSS-ANC HIV prevalence (0.92% vs. 1.22% in Andhra Pradesh, 0.65% vs. 0.89% in Karnataka, 0.52% vs. 0.60% in Maharashtra, p<0.001 for all three states. In all three states, HIV prevalence from PPTCT centres that were part of the sentinel surveillance was comparable to HSS-ANC prevalence but significantly higher than PPTCT centres that were not part of the sentinel surveillance. HIV prevalence from PPTCT data was comparable to that from general population surveys. In all three states, significant declines in HIV prevalence between 2007 and 2010 were observed with the PPTCT data set. District level analyses of HIV trends and sub-district level analysis of HIV prevalence were possible using the PPTCT and not the HSS-ANC data sets. CONCLUSION: HIV prevalence from PPTCT may be a better proxy for general population prevalence than HSS-ANC. PPTCT data allow for analysis of HIV prevalence and trends at smaller geographic units, which is important for decentralized planning of HIV/AIDS programming. With further improvements to the system, India could replace its HSS-ANC with PPTCT programme data for surveillance.

  15. Transmissibility studies of vacuolar changes in the rostral colliculus of pigs

    Directory of Open Access Journals (Sweden)

    Spencer Yvonne I

    2009-09-01

    Full Text Available Abstract Background Histopathological examinations of brains from healthy pigs have revealed localised vacuolar changes, predominantly in the rostral colliculus, that are similar to the neuropil vacuolation featured in the transmissible spongiform encephalopathies and have been described in pigs challenged parenterally with the agent causing bovine spongiform encephalopathy (BSE. Feedstuff containing BSE-contaminated meat and bone meal (MBM may have been fed to pigs prior to the ban of mammalian MBM in feed of farmed livestock in the United Kingdom in 1996, but there is no evidence of the natural occurrence of a transmissible spongiform encephalopathy (TSE in the domestic pig. Furthermore, experimental transmission of BSE to pigs by the oral route has been unsuccessful. A study was conducted to investigate whether the localised vacuolar changes in the porcine brain were associated with a transmissible aetiology and therefore biologically significant. Two groups of ten pigs were inoculated parenterally with vacuolated rostral colliculus from healthy pigs either born before 1996 or born after 1996. Controls included ten pigs similarly inoculated with rostral colliculus from New Zealand-derived pigs and nine pigs inoculated with a bovine BSE brain homogenate. Results None of the pigs inoculated with rostral colliculus developed a TSE-like neurological disease up to five years post inoculation when the study was terminated, and disease-associated prion protein, PrPd, was not detected in the brains of these pigs. By contrast, eight of nine BSE-inoculated pigs developed neurological signs, two of which had detectable PrPd by postmortem tests. No significant histopathological changes were detected to account for the clinical signs in the PrPd-negative, BSE-inoculated pigs. Conclusion The findings in this study suggest that vacuolation in the porcine rostral colliculus is not caused by a transmissible agent and is probably a clinically insignificant

  16. Changes in corticospinal transmission following 8 weeks of ankle joint immobilization

    DEFF Research Database (Denmark)

    Leukel, Christian; Taube, Wolfgang; Rittweger, Jörn;

    2015-01-01

    . Immobilization had no significant effects on spinal reflex measures. CONCLUSIONS: 8weeks of ankle joint immobilization was accompanied by pathway-specific modulation of corticospinal transmission. SIGNIFICANCE: It is particularly interesting that fast corticospinal projections were unaffected as these are......OBJECTIVES: Joint immobilization has previously been shown to modulate corticospinal excitability. The present study investigated changes in the excitability of distinct fractions of the corticospinal pathway by means of conditioning the H-reflex with transcranial magnetic stimulation (TMS) of the...... primary motor cortex (Hcond). This method allows assessment of transmission in fast (monosynaptic) and slow(er) (polysynaptic) corticospinal pathways. METHODS: 9 subjects underwent 8weeks of unilateral ankle joint immobilization during daytime, 7 subjects served as controls. The measures obtained before...

  17. Low Rates of Mother-to-Child HIV Transmission in a Routine Programmatic Setting in Lilongwe, Malawi

    OpenAIRE

    Maria H Kim; Ahmed, Saeed; Preidis, Geoffrey A.; Abrams, Elaine J.; Mina C Hosseinipour; Giordano, Thomas P; Chiao, Elizabeth Y.; Paul, Mary E.; Bhalakia, Avni; Nanthuru, Debora; Kazembe, Peter N.

    2013-01-01

    Background The Tingathe program utilizes community health workers to improve prevention of mother-to-child transmission (PMTCT) service delivery. We evaluated the impact of antiretroviral (ARV) regimen and maternal CD4+ count on HIV transmission within the Tingathe program in Lilongwe, Malawi. Methods We reviewed clinical records of 1088 mother-infant pairs enrolled from March 2009 to March 2011 who completed follow-up to first DNA PCR. Eligibility for antiretroviral treatment (ART) was deter...

  18. The age patterns of severe malaria syndromes in sub-Saharan Africa across a range of transmission intensities and seasonality settings

    Directory of Open Access Journals (Sweden)

    Greenwood Brian

    2010-10-01

    Full Text Available Abstract Background A greater understanding of the relationship between transmission intensity, seasonality and the age-pattern of malaria is needed to guide appropriate targeting of malaria interventions in different epidemiological settings. Methods A systematic literature review identified studies which reported the age of paediatric hospital admissions with cerebral malaria (CM, severe malarial anaemia (SMA, or respiratory distress (RD. Study sites were categorized into a 3 × 2 matrix of Plasmodium falciparum transmission intensity and seasonality. Probability distributions were fitted by maximum likelihood methods, and best fitting models were used to estimate median ages and to represent graphically the age-pattern of each outcome for each transmission category in the matrix. Results A shift in the burden of CM towards younger age groups was seen with increasing intensity of transmission, but this was not the case for SMA or RD. Sites with 'no marked seasonality' showed more evidence of skewed age-patterns compared to areas of 'marked seasonality' for all three severe malaria syndromes. Conclusions Although the peak age of CM will increase as transmission intensity decreases in Africa, more than 75% of all paediatric hospital admissions of severe malaria are likely to remain in under five year olds in most epidemiological settings.

  19. Climate change and the future Nordic electricity market - Supply, demand, trade and transmission

    International Nuclear Information System (INIS)

    The aim of this study has been to analyze the effects of climate changes on the Nordic electricity market. Concentration of greenhouse gases in the atmosphere influences the climate, which then alter the amount of primary energy for countries or regions where hydropower and wind power constitutes important parts of the energy supply. Besides, the demand effect of increased temperature may be large in economies where heating makes a large share of total energy demand. In this report we apply climate change calculations from natural science and detailed inflow data from the authorities to estimate the change in primary energy supply for the hydropower dominated Nordic electricity market. The estimated inflow model shows an increase in primary inflow in the following 40 years of 6-15 per cent in the Nordic countries. An estimated temperature model shows a 2-4 per cent initial drop in demand in the same time period, due to increasing temperature. Within the context of a perfect competition electricity market model, we simulate the total market outcome. As primary supply increases, the production cost decreases, prices drops and the total demand increases as the price effect dominates the temperature effect. Since the hydropower plants are located differently from large consumer groups, the stress on the transmission networks is dramatic for some regions, which in the next face may trigger new investments in transmission network capacities (author)

  20. A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting

    Directory of Open Access Journals (Sweden)

    Harris Ivor

    2010-09-01

    Full Text Available Abstract Background Many countries are scaling up malaria interventions towards elimination. This transition changes demands on malaria diagnostics from diagnosing ill patients to detecting parasites in all carriers including asymptomatic infections and infections with low parasite densities. Detection methods suitable to local malaria epidemiology must be selected prior to transitioning a malaria control programme to elimination. A baseline malaria survey conducted in Temotu Province, Solomon Islands in late 2008, as the first step in a provincial malaria elimination programme, provided malaria epidemiology data and an opportunity to assess how well different diagnostic methods performed in this setting. Methods During the survey, 9,491 blood samples were collected and examined by microscopy for Plasmodium species and density, with a subset also examined by polymerase chain reaction (PCR and rapid diagnostic tests (RDTs. The performances of these diagnostic methods were compared. Results A total of 256 samples were positive by microscopy, giving a point prevalence of 2.7%. The species distribution was 17.5% Plasmodium falciparum and 82.4% Plasmodium vivax. In this low transmission setting, only 17.8% of the P. falciparum and 2.9% of P. vivax infected subjects were febrile (≥38°C at the time of the survey. A significant proportion of infections detected by microscopy, 40% and 65.6% for P. falciparum and P. vivax respectively, had parasite density below 100/μL. There was an age correlation for the proportion of parasite density below 100/μL for P. vivax infections, but not for P. falciparum infections. PCR detected substantially more infections than microscopy (point prevalence of 8.71%, indicating a large number of subjects had sub-microscopic parasitemia. The concordance between PCR and microscopy in detecting single species was greater for P. vivax (135/162 compared to P. falciparum (36/118. The malaria RDT detected the 12 microscopy and

  1. Change in settings for early-season influenza vaccination among US adults, 2012 to 2013.

    Science.gov (United States)

    Clark, Sarah J; Gebremariam, Acham; Cowan, Anne E

    2016-12-01

    Vaccination in non-medical settings is recommended as a strategy to increase access to seasonal influenza vaccine. To evaluate change in early-season influenza vaccination setting, we analyzed data from the National Internet Flu Survey. Bivariate comparison of respondent characteristics by location of vaccination was assessed using chi-square tests. Multinomial logistic regression was performed to compare the predicted probability of being vaccinated in medical, retail, and mobile settings in 2012 vs 2013. In both 2012 and 2013, vaccination in medical settings was more likely among elderly adults, those with chronic conditions, and adults with a high school education or less. Adults 18-64 without a chronic condition had a lower probability of vaccination in the medical setting, and higher probability of vaccination in a retail or mobile setting, in 2013 compared to 2012. Adults 18-64 with a chronic condition had no change in their location of flu vaccination. Elderly adults had a lower probability of vaccination in the medical setting, and higher probability of vaccination in a retail setting, in 2013 compared to 2012. Non-medical settings continue to play an increasing role in influenza vaccination of adults, particularly for adults without a chronic condition and elderly adults. Retail and mobile settings should continue to be viewed as important mechanisms to ensure broad access to influenza vaccination. PMID:27486562

  2. Development of land data sets for studies of global climate change

    International Nuclear Information System (INIS)

    The U.S. Geological Survey has begun a major initiative to organize, produce, and distribute land data sets that will support the land data requirements of the global change science community. Satellite image data sets, produced from the National Oceanic and Atmospheric Administration's Advanced Very High Resolution Radiometer sensors, will be developed to provide repetitive, synoptic coverage of regional, continental, and global land areas. These data sets, integrated with related land data and supplemented by coregistered Landsat data sets, will enable scientists to quantify the fundamental land surface attributes that are needed to model land surface processes, to detect and monitor land surface change, and to map land cover. These well-structured, consistent land data sets will form the historical record of land observations prior to the era of the National Aeronautics and Space Administration's Earth Observing System sensors

  3. Antiretroviral Medication Adherence and Amplified HIV Transmission Risk Among Sexually Active HIV-Infected Individuals in Three Diverse International Settings.

    Science.gov (United States)

    Magidson, Jessica F; Li, Xin; Mimiaga, Matthew J; Moore, Ayana T; Srithanaviboonchai, Kriengkrai; Friedman, Ruth Khalili; Limbada, Mohammad; Hughes, James P; Cummings, Vanessa; Gaydos, Charlotte A; Elharrar, Vanessa; Celentano, David; Mayer, Kenneth H; Safren, Steven A

    2016-04-01

    Successful biomedical prevention/treatment-as-prevention (TasP) requires identifying individuals at greatest risk for transmitting HIV, including those with antiretroviral therapy (ART) nonadherence and/or 'amplified HIV transmission risk,' defined as condomless sex with HIV-uninfected/unknown-status partners when infectious (i.e., with detectable viremia or STI diagnosis according to Swiss criteria for infectiousness). This study recruited sexually-active, HIV-infected patients in Brazil, Thailand, and Zambia to examine correlates of ART nonadherence and 'amplified HIV transmission risk'. Lower alcohol use (OR = .71, p < .01) and higher health-related quality of life (OR = 1.10, p < .01) were associated with greater odds of ART adherence over and above region. Of those with viral load data available (in Brazil and Thailand only), 40 % met Swiss criteria for infectiousness, and 29 % had 'amplified HIV transmission risk.' MSM had almost three-fold (OR = 2.89, p < .001) increased odds of 'amplified HIV transmission risk' (vs. heterosexual men) over and above region. TasP efforts should consider psychosocial and contextual needs, particularly among MSM with detectable viremia. PMID:26246068

  4. Political science. When contact changes minds: an experiment on transmission of support for gay equality.

    Science.gov (United States)

    LaCour, Michael J; Green, Donald P

    2014-12-12

    Can a single conversation change minds on divisive social issues, such as same-sex marriage? A randomized placebo-controlled trial assessed whether gay (n = 22) or straight (n = 19) messengers were effective at encouraging voters (n = 972) to support same-sex marriage and whether attitude change persisted and spread to others in voters' social networks. The results, measured by an unrelated panel survey, show that both gay and straight canvassers produced large effects initially, but only gay canvassers' effects persisted in 3-week, 6-week, and 9-month follow-ups. We also find strong evidence of within-household transmission of opinion change, but only in the wake of conversations with gay canvassers. Contact with gay canvassers further caused substantial change in the ratings of gay men and lesbians more generally. These large, persistent, and contagious effects were confirmed by a follow-up experiment. Contact with minorities coupled with discussion of issues pertinent to them is capable of producing a cascade of opinion change. PMID:25504721

  5. Changes to TSR control set due to changes in mission and lessons learned

    International Nuclear Information System (INIS)

    Previous Technical Safety Requirements (TSRs) established to support plutonium production activities at the Rocky Flats Environmental Technology Site (RFETS) were heavily focused on engineered safety features that would mitigate potential accidents. With the change in mission in 1992 to Site closure, and considering antiquated equipment nearing the end of their useful life, a change in philosophy was adopted to emphasize preventive controls that are mostly administrative. The new Administrative Controls (ACs) developed in the last few years include discrete attributes of safety management programs (SMPs) that are specifically credited to prevent or mitigate an accident, and include requirements on handling individual deviations, programmatic deficiencies, and TSR AC violations. The primary benefit of these changes is fewer requirements on equipment that allow the contractor more flexibility to maintain the defense-in-depth safety systems in a more cost-effective manner. A disadvantage of these new ACs is that implementation has become cumbersome and difficult to manage, e.g., resulted in an increased burden of demonstrating compliance and required an additional infrastructure to track deviations and deficiencies. In order to improve the efficiency of the authorization basis (AB) process to support accelerated Site closure according to the 2006 Plan, the Site has recently modified the ABs to better focus on the programmatic elements that were credited in the accident analyses, and to rely on the Integrated Safety Management System to implement SMPs via one general TSR AC requirement. At the request of DOE/RFFO, a self-assessment of the Rocky Flats AB program was performed in November 1998 by Victor Stello, DOE Headquarters, along with representatives from other DOE sites and Defense Programs. Results of this self-assessment confirmed that the proposed AC changes would be beneficial and provided specific recommendations

  6. Overhead tank is the potential breeding habitat of Anopheles stephensi in an urban transmission setting of Chennai, India

    OpenAIRE

    Thomas, Shalu; Ravishankaran, Sangamithra; Justin, Johnson A; Asokan, Aswin; Mathai, Manu T.; Valecha, Neena; Thomas, Matthew B; Eapen, Alex

    2016-01-01

    Background Wells and overhead tanks (OHT) are the major breeding sources of the local malaria vector, Anopheles stephensi in the Indian city of Chennai; they play a significant role in vector breeding, and transmission of urban malaria. Many other man-made breeding habitats, such as cemented cisterns/containers, barrels or drums, sumps or underground tanks, and plastic pots/containers are maintained to supplement water needs, temporarily resulting in enhanced mosquito/vector breeding. Correla...

  7. An update: choice architecture as a means to change eating behaviour in self-service settings

    DEFF Research Database (Denmark)

    Skov, Laurits Rohden; Perez-Cueto, Armando

    Objective: The primary objective of this review was to update the current evidence-base for the use of choice architecture as a means to change eating behaviour in self-service eating settings, hence potentially reducing energy intake. Methodology: 12 databases were searched systematically for...... food choices. The majority of studies were of very weak quality and future research should emphasize a real-life setting and compare their results with the effect of other more well-established interventions on food behaviour in self-service eating settings. Key findings: An increasing interest in the...

  8. Priority interventions to reduce HIV transmission in sex work settings in sub-Saharan Africa and delivery of these services

    NARCIS (Netherlands)

    M. Chersich (Matthew); S. Luchters (Stanley); I. Ntaganira (Innocent); A. Gerbase (Antonio); Y-R. Lo (Ying-Ru); F. Scorgie (Fiona); R. Steen (Richard)

    2012-01-01

    textabstractIntroduction: Virtually no African country provides HIV prevention services in sex work settings with an adequate scale and intensity. Uncertainty remains about the optimal set of interventions and mode of delivery. Methods: We systematically reviewed studies reporting interventions for

  9. Paradigms, Mental Models, and Mind-Sets: Triple Barriers to Transformational Change in School Systems

    Science.gov (United States)

    Duffy, Francis M.

    2014-01-01

    This article presents a simile for understanding the power of paradigms, mental models, and mind-sets as religion-like phenomena. The author clarifies the meaning of the three phenomena to help readers to see how the phenomena become significant sources of resistance to change. He concludes by outlining a paradigm-shifting process to assist…

  10. Effects of Goal Setting on Dietary and Physical Activity Changes in the Boy Scout Badge Projects

    Science.gov (United States)

    Latif, Hira; Watson, Kathy; Nguyen, Nga; Thompson, Debbe; Baranowski, Janice; Jago, Russell; Cullen, Karen W.; Baranowski, Tom

    2011-01-01

    Background: This study evaluates the relationship of goal setting to low-fat vegetable (LV) and fruit/100% juice (FJ) consumption and physical activity (PA) change. Methods: A total of 473 10- to 14-year-old Boy Scouts from Houston took part in a 9-week intervention. A two-group (LV and FJ or PA) intervention design was used with each group…

  11. Changes in Mobility of Children with Cerebral Palsy over Time and across Environmental Settings

    Science.gov (United States)

    Tieman, Beth L.; Palisano, Robert J.; Gracely, Edward J.; Rosenbaum, Peter L.; Chiarello, Lisa A.; O'Neil, Margaret E.

    2004-01-01

    This study examined changes in mobility methods of children with cerebral palsy (CP) over time and across environmental settings. Sixty-two children with CP, ages 6-14 years and classified as levels II-IV on the Gross Motor Function Classification System, were randomly selected from a larger data base and followed for three to four years. On each…

  12. Addressing HIV in the School Setting: Application of a School Change Model

    Science.gov (United States)

    Walsh, Audra St. John; Chenneville, Tiffany

    2013-01-01

    This paper describes best practices for responding to youth with human immunodeficiency virus (HIV) in the school setting through the application of a school change model designed by the World Health Organization. This model applies a whole school approach and includes four levels that span the continuum from universal prevention to direct…

  13. REACH, non-testing approaches and the urgent need for a change in mind set

    NARCIS (Netherlands)

    Schaafsma, G.; Kroese, E.D.; Tielemans, E.L.J.P.; Sandt, J.J.M. van de; Leeuwen, C.J. van

    2009-01-01

    The objectives of REACH cannot be achieved under the current risk assessment approach. A change in mind set among all the relevant stakeholders is needed: risk assessment should move away from a labor-intensive and animal-consuming approach to intelligent and pragmatic testing, by combining exposure

  14. Climate Change and Aedes Vectors: 21st Century Projections for Dengue Transmission in Europe.

    Science.gov (United States)

    Liu-Helmersson, Jing; Quam, Mikkel; Wilder-Smith, Annelies; Stenlund, Hans; Ebi, Kristie; Massad, Eduardo; Rocklöv, Joacim

    2016-05-01

    Warming temperatures may increase the geographic spread of vector-borne diseases into temperate areas. Although a tropical mosquito-borne viral disease, a dengue outbreak occurred in Madeira, Portugal, in 2012; the first in Europe since 1920s. This outbreak emphasizes the potential for dengue re-emergence in Europe given changing climates. We present estimates of dengue epidemic potential using vectorial capacity (VC) based on historic and projected temperature (1901-2099). VC indicates the vectors' ability to spread disease among humans. We calculated temperature-dependent VC for Europe, highlighting 10 European cities and three non-European reference cities. Compared with the tropics, Europe shows pronounced seasonality and geographical heterogeneity. Although low, VC during summer is currently sufficient for dengue outbreaks in Southern Europe to commence-if sufficient vector populations (either Ae. aegypti and Ae. albopictus) were active and virus were introduced. Under various climate change scenarios, the seasonal peak and time window for dengue epidemic potential increases during the 21st century. Our study maps dengue epidemic potential in Europe and identifies seasonal time windows when major cities are most conducive for dengue transmission from 1901 to 2099. Our findings illustrate, that besides vector control, mitigating greenhouse gas emissions crucially reduces the future epidemic potential of dengue in Europe. PMID:27322480

  15. SIMULATION OF VARIOUS QoS PARAMETERS IN A HIGH DENSITY MANET SET-UP USING AODV nthBR PROTOCOL FOR MULTIMEDIA TRANSMISSION, DATA TRANSMISSION AND UNDER CONGESTION SCENARIO

    Directory of Open Access Journals (Sweden)

    Meena Rao

    2015-09-01

    Full Text Available Mobile ad hoc networks (MANETs are a setup of several independent nodes that are capable of transmitting any kind of data by themselves. In MANETs, the node themselves act as routers and the setup can either be single hop or multihop depending on the application. These devices have wide and varied applications; like in military deployment, for network set up in meetings, electronic classrooms etc. As the applications and use of MANETs has increased, it has also become imminent for MANETs to support multimedia transmission, high quality data transmission and also to work efficiently in a congestion scenario. To support these parameters it is necessary to have a robust routing protocol that provides good Quality of Service (QoS parameters under different conditions. In this paper the authors simulate transmission of multimedia traffic with AODV nthBR routing protocol for a high density MANET setup. AODV nthBR routing protocol is also simulated for a congestion scenario and the results are then compared with the existing routing protocols.

  16. Minimizing the Risk of Disease Transmission in Emergency Settings: Novel In Situ Physico-Chemical Disinfection of Pathogen-Laden Hospital Wastewaters

    OpenAIRE

    Sozzi, Emanuele; Fabre, Kerline; Fesselet, Jean-François; Ebdon, James E.; Taylor, Huw

    2015-01-01

    The operation of a health care facility, such as a cholera or Ebola treatment center in an emergency setting, results in the production of pathogen-laden wastewaters that may potentially lead to onward transmission of the disease. The research presented here evaluated the design and operation of a novel treatment system, successfully used by Médecins Sans Frontières in Haiti to disinfect CTC wastewaters in situ, eliminating the need for road haulage and disposal of the waste to a poorly-manag...

  17. Choice architecture as a means to change eating behaviour in self-service settings

    DEFF Research Database (Denmark)

    Skov, Laurits Rohden; Lourenco, Sofia; Laub Hansen, Gitte;

    2013-01-01

    Summary: The primary objective of this review was to investigate the current evidence-base for the use of choice architecture as a means to change eating behaviour in self-service eating settings, hence potentially reduce calorie intake. 12 databases were searched systematically for experimental...... food choice, whilst (ii) manipulating the plate and cutlery size has an inconclusive effect on consumption volume. Finally, (iii) assortment manipulation and (iv) payment option manipulation was associated with healthier food choices. The majority of studies were of very weak quality and future...... research should emphasise a real life setting and compare their results with the effect of other more well-established interventions on food behaviour in self-service eating settings....

  18. A set of fuzzy systems to automate the manual procedures for reactor power level changes

    International Nuclear Information System (INIS)

    In this chapter, we describe a set of fuzzy systems which automate the manual part of procedures being used in the reactor operations for PWR-type nuclear power plants. One of the fuzzy systems evaluates the total power defect as a function of the boron concentration and the reactor power level. Others are used to compute the amount of step changes for the control rod as a function of the current rod position and the increment of the total power defect needed for the power level change. Each fuzzy system is either an exact or an approximate representation of the cubic spline interpolation for the corresponding function provided as graphs. The resulting set of fuzzy systems not only improves the efficiency in performing the curve readings but also reduces the interpolation errors involved. (orig.)

  19. Assessment of malaria transmission changes in Africa, due to the climate impact of land use change using Coupled Model Intercomparison Project Phase 5 earth system models.

    Science.gov (United States)

    Tompkins, Adrian M; Caporaso, Luca

    2016-01-01

    Using mathematical modelling tools, we assessed the potential for land use change (LUC) associated with the Intergovernmental Panel on Climate Change low- and high-end emission scenarios (RCP2.6 and RCP8.5) to impact malaria transmission in Africa. To drive a spatially explicit, dynamical malaria model, data from the four available earth system models (ESMs) that contributed to the LUC experiment of the Fifth Climate Model Intercomparison Project are used. Despite the limited size of the ESM ensemble, stark differences in the assessment of how LUC can impact climate are revealed. In three out of four ESMs, the impact of LUC on precipitation and temperature over the next century is limited, resulting in no significant change in malaria transmission. However, in one ESM, LUC leads to increases in precipitation under scenario RCP2.6, and increases in temperature in areas of land use conversion to farmland under both scenarios. The result is a more intense transmission and longer transmission seasons in the southeast of the continent, most notably in Mozambique and southern Tanzania. In contrast, warming associated with LUC in the Sahel region reduces risk in this model, as temperatures are already above the 25-30°C threshold at which transmission peaks. The differences between the ESMs emphasise the uncertainty in such assessments. It is also recalled that the modelling framework is unable to adequately represent local-scale changes in climate due to LUC, which some field studies indicate could be significant. PMID:27063732

  20. Structure change of Xe precipitates embedded in Al studied by analytical transmission electron microscopy

    International Nuclear Information System (INIS)

    High-resolution transmission electron microscopy (HRTEM), electron energy loss spectroscopy (EELS) and energy filtered imaging (EFI) were employed to characterize the structure of precipitates of Xe implanted in Al metal, as well as their structure change as a function of temperature ranging from 300 to 858 K. HRTEM observation revealed that crystalline and non-crystalline Xe precipitates coexist at room temperature. The critical size so precipitates between the crystalline and non-crystalline states is about 5.5 m. In in-situ annealing, the crystalline precipitates start amorphization at 623 K and complete it at 773 K. Low energy loss peaks are recognized at 14.6 and 15.3 eV in the EELS at 300 K and 773 K, respectively. These peaks are considered to come from the Xe precipitates in Al. Energy shift of Xe-M4,5 edge to lower energy loss and an extra peak in Xe-M4,5 edge are detected in EELS aat 300 K in connection with the crystallization of the Xe precipitates. However, the Xe-M4,5 edge becomes identical in position and shape at 773 K to that of gaseous Xe. It suggests that the Xe-precipitates exist in the gaseous state at 773 K. (author)

  1. Age-related changes in attentional selection: quality of task set or degradation of task set across time?

    Science.gov (United States)

    Jackson, Jonathan D; Balota, David A

    2013-09-01

    The present study explores the nature of attentional selection in younger and older adults. Following R. De Jong, E. Berendsen, and R. Cools (1999, Acta Psychologica, Vol. 101, pp. 379-394), we manipulated the response to stimulus interval (RSI) in two attentional selection paradigms to examine if there are age-related differences in the quality of task set and/or the maintenance of task set across time. In Experiment 1, we found that the interference effect in a spatial interference task was (a) overall larger in older adults compared with younger adults, and (b) smaller at the short RSI (200 ms) compared with the long RSI (2000 ms), and (c) not associated with an interaction between age and RSI. The second experiment explored the same variables in a Stroop color interference paradigm. Again, older adults produced a disproportionately larger interference effect than younger adults, the interference effect was smaller at the short RSI compared with the long RSI, and there was no evidence of an interaction between age and RSI. In both experiments, the larger interference effect could not be attributed to age-related general slowing and there was evidence from Vincentile analyses of increasing interference and age effects at the slower response latencies. These results indicate that attentional selection deficits in these two experiments were due to a breakdown in the quality of the task set as opposed to age-related differences in the maintenance of the task set across time. PMID:23834491

  2. Synaptic transmission changes in fear memory circuits underlie key features of an animal model of schizophrenia.

    Science.gov (United States)

    Pollard, Marie; Varin, Christophe; Hrupka, Brian; Pemberton, Darrel J; Steckler, Thomas; Shaban, Hamdy

    2012-02-01

    Non-competitive antagonists of the N-methyl-d-aspartate receptor (NMDA) such as phencyclidine (PCP) elicit schizophrenia-like symptoms in healthy individuals. Similarly, PCP dosing in rats produces typical behavioral phenotypes that mimic human schizophrenia symptoms. Although schizophrenic behavioral phenotypes of the PCP model have been extensively studied, the underlying alterations of intrinsic neuronal properties and synaptic transmission in relevant limbic brain microcircuits remain elusive. Acute brain slice electrophysiology and immunostaining of inhibitory neurons were used to identify neuronal circuit alterations of the amygdala and hippocampus associated with changes in extinction of fear learning in rats following PCP treatment. Subchronic PCP application led to impaired long-term potentiation (LTP) and marked increases in the ratio of NMDA to 2-amino-3(5-methyl-3-oxo-1,2-oxazol-4-yl)propionic acid (AMPA) receptor-mediated currents at lateral amygdala (LA) principal neurons without alterations in parvalbumin (PV) as well as non-PV, glutamic acid decarboxylase 67 (GAD 67) immunopositive neurons. In addition, LTP was impaired at the Schaffer collateral to CA1 hippocampal pathway coincident with a reduction in colocalized PV and GAD67 immunopositive neurons in the CA3 hippocampal area. These effects occurred without changes in spontaneous events or intrinsic membrane properties of principal cells in the LA. The impairment of LTP at both amygdalar and hippocampal microcircuits, which play a key role in processing relevant survival information such as fear and extinction memory concurred with a disruption of extinction learning of fear conditioned responses. Our results show that subchronic PCP administration in rats impairs synaptic functioning in the amygdala and hippocampus as well as processing of fear-related memories. PMID:22085880

  3. Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study

    International Nuclear Information System (INIS)

    Nuclear alterations are a well-known manifestation of cancer. However, little is known about the early, microscopically-undetectable stages of malignant transformation. Based on the phenomenon of field cancerization, the tissue in the field of a tumor can be used to identify and study the initiating events of carcinogenesis. Morphological changes in nuclear organization have been implicated in the field of colorectal cancer (CRC), and we hypothesize that characterization of chromatin alterations in the early stages of CRC will provide insight into cancer progression, as well as serve as a biomarker for early detection, risk stratification and prevention. For this study we used transmission electron microscopy (TEM) images of nuclei harboring pre-neoplastic CRC alterations in two models: a carcinogen-treated animal model of early CRC, and microscopically normal-appearing tissue in the field of human CRC. We quantify the chromatin arrangement using approaches with two levels of complexity: 1) binary, where chromatin is separated into areas of dense heterochromatin and loose euchromatin, and 2) grey-scale, where the statistics of continuous mass-density distribution within the nucleus is quantified by its spatial correlation function. We established an increase in heterochromatin content and clump size, as well as a loss of its characteristic peripheral positioning in microscopically normal pre-neoplastic cell nuclei. Additionally, the analysis of chromatin density showed that its spatial distribution is altered from a fractal to a stretched exponential. We characterize quantitatively and qualitatively the nanoscale structural alterations preceding cancer development, which may allow for the establishment of promising new biomarkers for cancer risk stratification and diagnosis. The findings of this study confirm that ultrastructural changes of chromatin in field carcinogenesis represent early neoplastic events leading to the development of well

  4. Global change data sets: Excerpts from the Master Directory, version 2.0

    International Nuclear Information System (INIS)

    The recent awakening to the reality of human-induced changes to the environment has resulted in an organized effort to promote global change research. The goal of this research as outlined by NASA's Earth System Science Committee (Earth System Science: A closer View, 1988) is to understand the entire Earth system on a global scale by describing how its component parts and their interactions have evolved, how they function, and how they may be expected to evolve on all timescales. The practical result is the capacity to predict that evolution over the next decade to century. Key variables important for the study of global change include external forcing factors (solar radiance, UV flux), radiatively and chemically important trace species (CO2, CH4, N2O, etc.), atmospheric response variables (temperature, pressure, winds), landsurface properties (river run-off, snow cover, albedo, soil moisture, vegetation cover), and oceanic variables (sea surface temperature, sea ice extent, sea level ocean wind stress, currents, chlorophyll, biogeochemical fluxes). The purpose of this document is to identify existing data sets available (both remotely sensed and in situ data) covering some of these variables. This is not intended to be a complete list of global change data, but merely a highlight of what is available. The information was extracted from the Master Directory (MD), an on-line scientific data information service which may be used by any researcher. This report contains the coverage dates for the data sets, sources (satellites, instruments) of the data and where they are archived

  5. Changes of transmission characteristics for different optic radiation incidence angles in filters protecting against hazardous infrared radiation

    OpenAIRE

    Grzegorz Gralewicz; Janusz Kubrak; Grzegorz Owczarek

    2015-01-01

    The paper presents the fundamental information concerning the types of protective optical filters used for protection against hazardous radiation within the visible and near-infrared spectrum range. The changes of transmission characteristics for different optic radiation angles of incidence with metallic reflective filters and interference filters have been analyzed. The results demonstrate that such changes exert no effect on the level of protection provided by the filters.

  6. [Histochemical findings of and fine structural changes in motor endplates in diseases with neuromuscular transmission abnormalities].

    Science.gov (United States)

    Yoshimura, Toshiro; Motomura, Masakatsu; Tsujihata, Mitsuhiro

    2011-07-01

    We herein review the histochemical findings and fine structural changes of motor endplates associated with diseases causing neuromuscular transmission abnormalities. In anti-acetylcholine receptor (AChR) antibody-positive myasthenia gravis (MG), type 2 fiber atrophy is observed, and the motor endplates show a reduction in the nerve terminal area, simplification of the postsynaptic membrane, decreased number of acetylcholine receptors, and deposition of immune complexes. In anti-MuSK antibody-positive MG, the fine structure shows a decrease in the postsynaptic membrane length, but the secondary synaptic cleft is preserved. There is no decrease in the number of AChRs, and there are no deposits of immune complexes at the motor endplates. Patients with Lambert-Eaton myasthenic syndrome show type 2 fiber atrophy, their motor endplates show a decrease in both the mean postsynaptic area and postsynaptic membrane length in the brachial biceps muscle. Congenital myasthenic syndrome with episodic apnea is characterized only by small-sized synaptic vesicles; the postsynaptic area is preserved. In subjects with congenital myasthenic syndrome with acetylcholinesterase deficiency, quantitative electron microscopy reveals a significant decrease in the nerve terminal size and presynaptic membrane length; further, the Schwann cell processes extend into the primary synaptic cleft, and partially or completely occlude the presynaptic membrane. The postsynaptic folds are degenerated, and associated with pinocytotic vesicles and labyrinthine membranous networks. Patients with slow-channel congenital myasthenia syndrome show type 1 fiber predominance, and their junctional folds are typically degenerated with widened synaptic space and loss of AChRs. Patients with AChR deficiency syndrome caused by recessive mutations in AChR subunits also show type 1 fiber predominance, and while most junctional folds are normal, some are simplified and have smaller than normal endplates. Rapsin and Mu

  7. Empirical investigation of SET seasoning effects in Phase Change Memory arrays

    Science.gov (United States)

    Zambelli, C.; Chimenton, A.; Olivo, P.

    2011-04-01

    In this work we have investigated the seasoning effect in SET state occurring during cycling of multimegabit Phase Change Memory arrays. The impact of the erasing waveform on this phenomenon has been experimentally evaluated. The physical nature of the phenomenon has been discussed in relation to the electro-thermal characteristics of the active material. The study of such phenomenon is also important to comprehend the transition dynamics of the GST material towards its crystalline state and to develop accurate models allowing an estimate of the PCM cells behavior as a function of the operative cycles.

  8. Literature survey: Relations between stress change, deformation and transmissivity for fractures and deformation zones based on in situ investigations

    International Nuclear Information System (INIS)

    This literature survey is focused upon relations between stress change, deformation and transmissivity for fractures and deformation zones and aims at compiling and commenting on relevant information and references with focus on data from in situ investigations. Main issues to investigate are: - Impact of normal stress change and deformation on transmissivity, for fractures and deformation zones. - Impact of shear stress and displacement on transmissivity, for fractures and deformation zones for different normal load conditions. Considering the line of research within the area, the following steps in the development can be identified. During the 1970's and 1980's, the fundamentals of rock joint deformation were investigated and identification and description of mechanisms were made in the laboratory. In the 1990's, coupling of stress-flow properties of rock joints were made using hydraulic testing to identify and describe the mechanisms in the field. Both individual fractures and deformation zones were of interest. In situ investigations have also been the topic of interest the last ten years. Further identification and description of mechanisms in the field have been made including investigation and description of system of fractures, different types of fractures (interlocked/mated or mismatched/unmated) and how this is coupled to the hydromechanical behavior. In this report, data from in situ investigations are compiled and the parameters considered to be important to link fracture deformation and transmissivity are normal stiffness, kn and hydraulic aperture, bh. All data except for those from one site originate from investigations performed in granitic rock. Normal stiffness, kn, and hydraulic aperture, bh, are correlated, even though data are scattered. In general, the largest variation is seen for small hydraulic apertures and high normal stiffness. The increasing number of contact points (areas) and fracture filling are likely explanations. To conclude

  9. Routinization of HIV Testing in an Inpatient Setting: A Systematic Process for Organizational Change.

    Science.gov (United States)

    Mignano, Jamie L; Miner, Lucy; Cafeo, Christina; Spencer, Derek E; Gulati, Mangla; Brown, Travis; Borkoski, Ruth; Gibson-Magri, Kate; Canzoniero, Jenna; Gottlieb, Jonathan E; Rowen, Lisa

    2016-01-01

    In 2006, the U.S. Centers for Disease Control and Prevention released revised recommendations for routinization of HIV testing in healthcare settings. Health professionals have been challenged to incorporate these guidelines. In March 2013, a routine HIV testing initiative was launched at a large urban academic medical center in a high prevalence region. The goal was to routinize HIV testing by achieving a 75% offer and 75% acceptance rate and promoting linkage to care in the inpatient setting. A systematic six-step organizational change process included stakeholder buy-in, identification of an interdisciplinary leadership team, infrastructure development, staff education, implementation, and continuous quality improvement. Success was measured by monitoring the percentage of offered and accepted HIV tests from March to December 2013. The targeted offer rate was exceeded consistently once nurses became part of the consent process (September 2013). Fifteen persons were newly diagnosed with HIV. Seventy-eight persons were identified as previously diagnosed with HIV, but not engaged in care. Through this process, patients who may have remained undiagnosed or out-of-care were identified and linked to care. The authors propose that this process can be replicated in other settings. Increasing identification and treatment will improve the individual patient's health and reduce community disease burden. PMID:26042762

  10. Orientation relationship, shape change and their traces in electron diffraction patterns and high-resolution transmission electron microscopy images

    International Nuclear Information System (INIS)

    This paper outlines a straightforward method that can be used to predict the total number of orientation relationships between a pair of lattices that can be related by an invariant plane strain transformation and the shape change associated with each of the orientation relationships. This paper also provides a simple technique for calculating the shape strain and crystallography directly from electron diffraction patterns or Fourier-transformed digital patterns of high-resolution transmission electron microscopy images. It demonstrates that many of those diffusional phase transformations that are traditionally classified as non-displacive exhibit in fact a remarkable shape change and that the shape change can even be a simple shear

  11. Tracing Mycobacterium tuberculosis transmission by whole genome sequencing in a high incidence setting: a retrospective population-based study in East Greenland.

    Science.gov (United States)

    Bjorn-Mortensen, K; Soborg, B; Koch, A; Ladefoged, K; Merker, M; Lillebaek, T; Andersen, A B; Niemann, S; Kohl, T A

    2016-01-01

    In East Greenland, a dramatic increase of tuberculosis (TB) incidence has been observed in recent years. Classical genotyping suggests a genetically similar Mycobacterium tuberculosis (Mtb) strain population as cause, however, precise transmission patterns are unclear. We performed whole genome sequencing (WGS) of Mtb isolates from 98% of culture-positive TB cases through 21 years (n = 182) which revealed four genomic clusters of the Euro-American lineage (mainly sub-lineage 4.8 (n = 134)). The time to the most recent common ancestor of lineage 4.8 strains was found to be 100 years. This sub-lineage further diversified in the 1970s, and massively expanded in the 1990s, a period of lowered TB awareness in Greenland. Despite the low genetic strain diversity, WGS data revealed several recent short-term transmission events in line with the increasing incidence in the region. Thus, the isolated setting and the uniformity of circulating Mtb strains indicated that the majority of East Greenlandic TB cases originated from one or few strains introduced within the last century. Thereby, the study shows the consequences of even short interruptions in TB control efforts in previously TB high incidence areas and demonstrates the potential role of WGS in detecting ongoing micro epidemics, thus guiding public health efforts in the future. PMID:27615360

  12. Sero-epidemiological evaluation of changes in Plasmodium falciparum and Plasmodium vivax transmission patterns over the rainy season in Cambodia

    Directory of Open Access Journals (Sweden)

    Cook Jackie

    2012-03-01

    Full Text Available Abstract Background In Cambodia, malaria transmission is low and most cases occur in forested areas. Sero-epidemiological techniques can be used to identify both areas of ongoing transmission and high-risk groups to be targeted by control interventions. This study utilizes repeated cross-sectional data to assess the risk of being malaria sero-positive at two consecutive time points during the rainy season and investigates who is most likely to sero-convert over the transmission season. Methods In 2005, two cross-sectional surveys, one in the middle and the other at the end of the malaria transmission season, were carried out in two ecologically distinct regions in Cambodia. Parasitological and serological data were collected in four districts. Antibodies to Plasmodium falciparum Glutamate Rich Protein (GLURP and Plasmodium vivax Merozoite Surface Protein-119 (MSP-119 were detected using Enzyme Linked Immunosorbent Assay (ELISA. The force of infection was estimated using a simple catalytic model fitted using maximum likelihood methods. Risks for sero-converting during the rainy season were analysed using the Classification and Regression Tree (CART method. Results A total of 804 individuals participating in both surveys were analysed. The overall parasite prevalence was low (4.6% and 2.0% for P. falciparum and 7.9% and 6.0% for P. vivax in August and November respectively. P. falciparum force of infection was higher in the eastern region and increased between August and November, whilst P. vivax force of infection was higher in the western region and remained similar in both surveys. In the western region, malaria transmission changed very little across the season (for both species. CART analysis for P. falciparum in the east highlighted age, ethnicity, village of residence and forest work as important predictors for malaria exposure during the rainy season. Adults were more likely to increase their antibody responses to P. falciparum during the

  13. Co-registration and bias corrections of satellite elevation data sets for quantifying glacier thickness change

    Directory of Open Access Journals (Sweden)

    C. Nuth

    2011-03-01

    Full Text Available There are an increasing number of digital elevation models (DEMs available worldwide for deriving elevation differences over time, including vertical changes on glaciers. Most of these DEMs are heavily post-processed or merged, so that physical error modelling becomes difficult and statistical error modelling is required instead. We propose a three-step methodological framework for assessing and correcting DEMs to quantify glacier elevation changes: (i remove DEM shifts, (ii check for elevation-dependent biases, and (iii check for higher-order, sensor-specific biases. A simple, analytic and robust method to co-register elevation data is presented in regions where stable terrain is either plentiful (case study New Zealand or limited (case study Svalbard. The method is demonstrated using the three global elevation data sets available to date, SRTM, ICESat and the ASTER GDEM, and with automatically generated DEMs from satellite stereo instruments of ASTER and SPOT5-HRS. After 3-D co-registration, significant biases related to elevation were found in some of the stereoscopic DEMs. Biases related to the satellite acquisition geometry (along/cross track were detected at two frequencies in the automatically generated ASTER DEMs. The higher frequency bias seems to be related to satellite jitter, most apparent in the back-looking pass of the satellite. The origins of the more significant lower frequency bias is uncertain. ICESat-derived elevations are found to be the most consistent globally available elevation data set available so far. Before performing regional-scale glacier elevation change studies or mosaicking DEMs from multiple individual tiles (e.g. ASTER GDEM, we recommend to co-register all elevation data to ICESat as a global vertical reference system.

  14. Co-registration and bias corrections of satellite elevation data sets for quantifying glacier thickness change

    Science.gov (United States)

    Nuth, C.; Kääb, A.

    2011-03-01

    There are an increasing number of digital elevation models (DEMs) available worldwide for deriving elevation differences over time, including vertical changes on glaciers. Most of these DEMs are heavily post-processed or merged, so that physical error modelling becomes difficult and statistical error modelling is required instead. We propose a three-step methodological framework for assessing and correcting DEMs to quantify glacier elevation changes: (i) remove DEM shifts, (ii) check for elevation-dependent biases, and (iii) check for higher-order, sensor-specific biases. A simple, analytic and robust method to co-register elevation data is presented in regions where stable terrain is either plentiful (case study New Zealand) or limited (case study Svalbard). The method is demonstrated using the three global elevation data sets available to date, SRTM, ICESat and the ASTER GDEM, and with automatically generated DEMs from satellite stereo instruments of ASTER and SPOT5-HRS. After 3-D co-registration, significant biases related to elevation were found in some of the stereoscopic DEMs. Biases related to the satellite acquisition geometry (along/cross track) were detected at two frequencies in the automatically generated ASTER DEMs. The higher frequency bias seems to be related to satellite jitter, most apparent in the back-looking pass of the satellite. The origins of the more significant lower frequency bias is uncertain. ICESat-derived elevations are found to be the most consistent globally available elevation data set available so far. Before performing regional-scale glacier elevation change studies or mosaicking DEMs from multiple individual tiles (e.g. ASTER GDEM), we recommend to co-register all elevation data to ICESat as a global vertical reference system.

  15. Minimizing the Risk of Disease Transmission in Emergency Settings: Novel In Situ Physico-Chemical Disinfection of Pathogen-Laden Hospital Wastewaters.

    Science.gov (United States)

    Sozzi, Emanuele; Fabre, Kerline; Fesselet, Jean-François; Ebdon, James E; Taylor, Huw

    2015-01-01

    The operation of a health care facility, such as a cholera or Ebola treatment center in an emergency setting, results in the production of pathogen-laden wastewaters that may potentially lead to onward transmission of the disease. The research presented here evaluated the design and operation of a novel treatment system, successfully used by Médecins Sans Frontières in Haiti to disinfect CTC wastewaters in situ, eliminating the need for road haulage and disposal of the waste to a poorly-managed hazardous waste facility, thereby providing an effective barrier to disease transmission through a novel but simple sanitary intervention. The physico-chemical protocols eventually successfully treated over 600 m3 of wastewater, achieving coagulation/flocculation and disinfection by exposure to high pH (Protocol A) and low pH (Protocol B) environments, using thermotolerant coliforms as a disinfection efficacy index. In Protocol A, the addition of hydrated lime resulted in wastewater disinfection and coagulation/flocculation of suspended solids. In Protocol B, disinfection was achieved by the addition of hydrochloric acid, followed by pH neutralization and coagulation/flocculation of suspended solids using aluminum sulfate. Removal rates achieved were: COD >99%; suspended solids >90%; turbidity >90% and thermotolerant coliforms >99.9%. The proposed approach is the first known successful attempt to disinfect wastewater in a disease outbreak setting without resorting to the alternative, untested, approach of 'super chlorination' which, it has been suggested, may not consistently achieve adequate disinfection. A basic analysis of costs demonstrated a significant saving in reagent costs compared with the less reliable approach of super-chlorination. The proposed approach to in situ sanitation in cholera treatment centers and other disease outbreak settings represents a timely response to a UN call for onsite disinfection of wastewaters generated in such emergencies, and the

  16. Minimizing the Risk of Disease Transmission in Emergency Settings: Novel In Situ Physico-Chemical Disinfection of Pathogen-Laden Hospital Wastewaters.

    Directory of Open Access Journals (Sweden)

    Emanuele Sozzi

    Full Text Available The operation of a health care facility, such as a cholera or Ebola treatment center in an emergency setting, results in the production of pathogen-laden wastewaters that may potentially lead to onward transmission of the disease. The research presented here evaluated the design and operation of a novel treatment system, successfully used by Médecins Sans Frontières in Haiti to disinfect CTC wastewaters in situ, eliminating the need for road haulage and disposal of the waste to a poorly-managed hazardous waste facility, thereby providing an effective barrier to disease transmission through a novel but simple sanitary intervention. The physico-chemical protocols eventually successfully treated over 600 m3 of wastewater, achieving coagulation/flocculation and disinfection by exposure to high pH (Protocol A and low pH (Protocol B environments, using thermotolerant coliforms as a disinfection efficacy index. In Protocol A, the addition of hydrated lime resulted in wastewater disinfection and coagulation/flocculation of suspended solids. In Protocol B, disinfection was achieved by the addition of hydrochloric acid, followed by pH neutralization and coagulation/flocculation of suspended solids using aluminum sulfate. Removal rates achieved were: COD >99%; suspended solids >90%; turbidity >90% and thermotolerant coliforms >99.9%. The proposed approach is the first known successful attempt to disinfect wastewater in a disease outbreak setting without resorting to the alternative, untested, approach of 'super chlorination' which, it has been suggested, may not consistently achieve adequate disinfection. A basic analysis of costs demonstrated a significant saving in reagent costs compared with the less reliable approach of super-chlorination. The proposed approach to in situ sanitation in cholera treatment centers and other disease outbreak settings represents a timely response to a UN call for onsite disinfection of wastewaters generated in such

  17. Minimizing the Risk of Disease Transmission in Emergency Settings: Novel In Situ Physico-Chemical Disinfection of Pathogen-Laden Hospital Wastewaters

    Science.gov (United States)

    Sozzi, Emanuele; Fabre, Kerline; Fesselet, Jean-François; Ebdon, James E.; Taylor, Huw

    2015-01-01

    The operation of a health care facility, such as a cholera or Ebola treatment center in an emergency setting, results in the production of pathogen-laden wastewaters that may potentially lead to onward transmission of the disease. The research presented here evaluated the design and operation of a novel treatment system, successfully used by Médecins Sans Frontières in Haiti to disinfect CTC wastewaters in situ, eliminating the need for road haulage and disposal of the waste to a poorly-managed hazardous waste facility, thereby providing an effective barrier to disease transmission through a novel but simple sanitary intervention. The physico-chemical protocols eventually successfully treated over 600 m3 of wastewater, achieving coagulation/flocculation and disinfection by exposure to high pH (Protocol A) and low pH (Protocol B) environments, using thermotolerant coliforms as a disinfection efficacy index. In Protocol A, the addition of hydrated lime resulted in wastewater disinfection and coagulation/flocculation of suspended solids. In Protocol B, disinfection was achieved by the addition of hydrochloric acid, followed by pH neutralization and coagulation/flocculation of suspended solids using aluminum sulfate. Removal rates achieved were: COD >99%; suspended solids >90%; turbidity >90% and thermotolerant coliforms >99.9%. The proposed approach is the first known successful attempt to disinfect wastewater in a disease outbreak setting without resorting to the alternative, untested, approach of ‘super chlorination’ which, it has been suggested, may not consistently achieve adequate disinfection. A basic analysis of costs demonstrated a significant saving in reagent costs compared with the less reliable approach of super-chlorination. The proposed approach to in situ sanitation in cholera treatment centers and other disease outbreak settings represents a timely response to a UN call for onsite disinfection of wastewaters generated in such emergencies, and the

  18. Offshore Power Transmission : Submarine high voltage transmission alternatives

    OpenAIRE

    Ulsund, Ragnar

    2009-01-01

    Offshore power transmission is becoming an increasingly important issue. To moderate climate change, world leaders have set environmental goals that will be very difficult to reach without renewable power production and the removal of production units with high emissions. Wind power and electrification have been the focus in this report. Plans for the expensive wind power are already moving offshore. This report has made an attempt at suggesting a guideline for well-suited transmission syst...

  19. Investigation of structural change of purple membrane in storage by transmission electron microscope and atomic force microscope

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The structural change of purple membrane during storage has been investigated by means of transmission electron microscope and atomic force microscope. It is found that many liposomes have spontaneously evolved from the purple membrane sheets isolated three years ago. The membrane proteins on the liposomes, bacteriorhodopsin, are still presented as trimers in 2-D hexagonal structure, which is the same as that in natural cell membrane. However, the cytoplasmic surface of purple membrane faced outside on the liposomes.

  20. Energy filtering transmission electron microscopy and atomistic simulations of tribo-induced hybridization change of nanocrystalline diamond coating

    OpenAIRE

    Bouchet, M.I.D.; Matta, C.; Vacher, B; Le-Mogne, T.; Martin, J. M.; Lautz, J. von; T. Ma; Pastewka, L.; Otschik, J.; Gumbsch, P.; Moseler, M.

    2015-01-01

    The tribofilm formed on nanocrystalline diamond coating during ultralow friction in presence of water and glycerol lubrication has been studied experimentally by energy filtering transmission electron microscopy (EF-TEM) and electron energy loss spectroscopy (EELS) on focus ion beam (FIB) cross sections. Surprisingly, even under mild tribological conditions, a tribo-induced hybridization change (sp(3) towards sp(2)) can be clearly detected at the top of the coating resulting in the formation ...

  1. Projecting the impact of climate change on the transmission of Ross River virus: methodological challenges and research needs.

    Science.gov (United States)

    Yu, W; Dale, P; Turner, L; Tong, S

    2014-10-01

    Ross River virus (RRV) is the most common vector-borne disease in Australia. It is vitally important to make appropriate projections on the future spread of RRV under various climate change scenarios because such information is essential for policy-makers to identify vulnerable communities and to better manage RRV epidemics. However, there are many methodological challenges in projecting the impact of climate change on the transmission of RRV disease. This study critically examined the methodological issues and proposed possible solutions. A literature search was conducted between January and October 2012, using the electronic databases Medline, Web of Science and PubMed. Nineteen relevant papers were identified. These studies demonstrate that key challenges for projecting future climate change on RRV disease include: (1) a complex ecology (e.g. many mosquito vectors, immunity, heterogeneous in both time and space); (2) unclear interactions between social and environmental factors; and (3) uncertainty in climate change modelling and socioeconomic development scenarios. Future risk assessments of climate change will ultimately need to better understand the ecology of RRV disease and to integrate climate change scenarios with local socioeconomic and environmental factors, in order to develop effective adaptation strategies to prevent or reduce RRV transmission. PMID:24612684

  2. An update: choice architecture as a means to change eating behaviour in self-service settings

    DEFF Research Database (Denmark)

    Skov, Laurits Rohden; Perez-Cueto, Armando

    2014-01-01

    Objective: The primary objective of this review was to update the current evidence-base for the use of choice architecture as a means to change eating behaviour in self-service eating settings, hence potentially reducing energy intake. Methodology: 12 databases were searched systematically...... for experimental studies with predefined choice architectural interventions in the period June 2011 - March 2012. The 12 included studies were grouped according to type of interventions and underwent a narrative synthesis. An update of the review was conducted during the summer of 2014. Results: The evidence...... indicates that (i) health labelling at point-of-purchase is associated with healthier food choice, whilst (ii) manipulating the plate and cutlery size has an inconclusive effect on consumption volume. Finally, (iii) assortment manipulation and (iv) payment option manipulation was associated with healthier...

  3. Electronic transmission of prescriptions : pre and post intervention changes in GP attitude

    OpenAIRE

    PEARCE, Kim; Coleman, Shirley; Mønness, Erik Neslein

    2008-01-01

    English: The Electronic Transmission of Prescriptions (ETP) scheme has become an important part of the UK Government’s plans for modernising the National Health Service1 (NHS). ETP pilot schemes were implemented by three consortia during 2002 and 2003, with a view to deciding which elements of the schemes were the most effective. Data for statistical analysis were collected after a 6 month trial period. During this time, the ETP pilots were subject to early teething problems and there were...

  4. Evaluating changes in the monetary transmission mechanism in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Franta, M.; Horváth, Roman; Rusnák, M.

    2014-01-01

    Roč. 46, č. 3 (2014), s. 827-842. ISSN 0377-7332 R&D Projects: GA ČR GA402/09/0965 Institutional support: RVO:67985556 Keywords : monetary transmission * Sign restrictions * Time-varying parameters Subject RIV: AH - Economics Impact factor: 0.693, year: 2014 http://library.utia.cas.cz/separaty/2015/E/horvath-0449955.pdf

  5. Translating Physical Activity Evidence to Hospital Settings: A Call for Culture Change.

    Science.gov (United States)

    Tucker, Sharon J; Carr, Lucas J

    2016-01-01

    Extensive evidence exists on the multiple physical and psychological benefits of physical activity (PA) across the lifespan. Yet, the vast majority of Americans engage in highly sedentary lifestyles, and most do not meet recommended PA levels that can achieve health benefits. Moreover, nurses and other healthcare providers are highly inconsistent in their PA recommendations to patients in all settings, as well as in achieving their own levels of PA. The consequences are growing obesity and health-related conditions, disability, and mortality. A culture change is sorely needed that reimagines and reintegrates PA into the course of daily life activities. In this article, we present the research on PA benefits, declining PA levels, and healthcare practice deficits and propose designing an inpatient unit of the future with a mission of PA for all that is integrated into the fabric and operations of the unit. Malcolm Gladwell's Tipping Point ideas are used as a change framework to guide strategies recommended in this futuristic unit. These strategies include leadership by clinical nurse specialists, engagement of other key people, resources, and structures. The entire process will require bold leadership and a willingness to think outside existing models of hospital care, which are costly and outdated. PMID:27309785

  6. Metabolic and Kidney Diseases in the Setting of Climate Change, Water Shortage, and Survival Factors.

    Science.gov (United States)

    Johnson, Richard J; Stenvinkel, Peter; Jensen, Thomas; Lanaspa, Miguel A; Roncal, Carlos; Song, Zhilin; Bankir, Lise; Sánchez-Lozada, Laura G

    2016-08-01

    Climate change (global warming) is leading to an increase in heat extremes and coupled with increasing water shortage, provides a perfect storm for a new era of environmental crises and potentially, new diseases. We use a comparative physiologic approach to show that one of the primary mechanisms by which animals protect themselves against water shortage is to increase fat mass as a means for providing metabolic water. Strong evidence suggests that certain hormones (vasopressin), foods (fructose), and metabolic products (uric acid) function as survival signals to help reduce water loss and store fat (which also provides a source of metabolic water). These mechanisms are intricately linked with each other and stimulated by dehydration and hyperosmolarity. Although these mechanisms were protective in the setting of low sugar and low salt intake in our past, today, the combination of diets high in fructose and salty foods, increasing temperatures, and decreasing available water places these survival signals in overdrive and may be accelerating the obesity and diabetes epidemics. The recent discovery of multiple epidemics of CKD occurring in agricultural workers in hot and humid environments may represent harbingers of the detrimental consequences of the combination of climate change and overactivation of survival pathways. PMID:27283495

  7. Wetlands as a Record of Climate Change and Hydrological Response in Arid Rift Settings

    Science.gov (United States)

    Ashley, G. M.

    2004-12-01

    Of all the terrestrial depositional settings, rift basins typically provide the greatest accommodation space, and consequently have some of the longest records of continental sedimentation. Lake deposits were the only rift component studied for records of long-term climatic change and for testing hypotheses of orbital forcing. Recently, the continuing quest for the paleontological and cultural records of human origins entombed in the sedimentary rocks of the East African Rift System raised questions concerning hydrologic and biologic response to climatic change. Additional issues are the impact of climate on paleolandscapes and the environmental stresses that might have affected human evolution. Other important indicators of rift hydrology, such as springs and wetlands are now emerging as viable records of climate change. Rift valley basins are shallow, hydrologically closed systems that are responsive to shifts in climate, and specifically sensitive to changes in the hydrologic budget (P-ET). Long term wet-dry cycles in the low latitudes are thought to be astronomically controlled, i.e. Milankovitch precession cycles (19-23 ka). In the tropics, precipitation (P) varies with changes in solar insolation which fluctuates similarly. Springs and groundwater-fed wetlands are common, however the sources and sustainability of water or what geologic factors lead to the formation and longevity of wetlands is not well established. It appears that rainfall is trapped on topographic highs (rift fault blocks and volcanoes). This meteoric water infiltrates quickly through porous volcanic rocks and is stored in aquifers and released slowly. As a component of the rift hydrologic system, wetlands appear to be reliable indicators of rainfall fluctuations on both Milankovitch and sub-Milankovitch time scales. Wetland sediments are commoner in the geologic record during times of higher rainfall and are less common during drier periods. Modern arid rift wetland records are peats and

  8. Malaria surveillance-response strategies in different transmission zones of the People's Republic of China: preparing for climate change

    Directory of Open Access Journals (Sweden)

    Yang Guo-Jing

    2012-12-01

    Full Text Available Abstract Background A sound understanding of malaria transmission patterns in the People’s Republic of China (P.R. China is crucial for designing effective surveillance-response strategies that can guide the national malaria elimination programme (NMEP. Using an established biology-driven model, it is expected that one may design and refine appropriate surveillance-response strategies for different transmission zones, which, in turn, assist the NMEP in the ongoing implementation period (2010–2020 and, potentially, in the post-elimination stage (2020–2050. Methods Environmental data obtained from 676 locations across P.R. China, such as monthly temperature and yearly relative humidity (YRH, for the period 1961–2000 were prepared. Smoothed surface maps of the number of months suitable for parasite survival derived from monthly mean temperature and YRH were generated. For each decade, the final malaria prediction map was overlaid by two masked maps, one showing the number of months suitable for parasite survival and the other the length of YRH map in excess of 60%. Results Considering multiple environmental factors simultaneously, the environmental variables suitable for malaria transmission were found to have shifted northwards, which was especially pronounced in northern P.R. China. The unstable suitable regions (transmission periods between five and six months showed increased transmission intensity due to prolonged suitable periods, especially in the central part of the country. Conclusion Adequate and effective surveillance-response strategies for NMEP should be designed to achieve the goal of malaria elimination in P.R. China by 2020, especially in the zones predicted to be the most vulnerable for climate change.

  9. Changes in nucleus accumbens dopamine transmission associated with fixed- and variable-time schedule-induced feeding.

    Science.gov (United States)

    Richardson, Nicole R; Gratton, Alain

    2008-05-01

    We examined the changes in nucleus accumbens (NAcc) dopamine (DA) transmission associated with non-contingent meal presentations under conditions of high (fixed time-, FT-schedule) and low (variable time-, VT-schedule) predictability. Of interest were the changes in NAcc DA transmission associated with discrepancies between the time food is expected and when it is actually presented. We used in vivo voltammetry to monitor NAcc DA levels as rats received, on the first and second test days, 30-s meals of condensed milk on a VT-52 schedule (inter-meal intervals of 32, 35, 40, 45, 52, 64, and 95 s). On the third and subsequent days meals were presented first on a VT-52 s schedule and then on an FT-52 s schedule. On day 1, monotonic increases in NAcc DA signals were observed during both meal consumption and the intervals between VT meal presentations. By day 2, however, meal presentations on the VT schedule elicited biphasic DA signal fluctuations; DA signals increased prior to each meal presentation but then started to decline during the feeding bout that followed. Fixed-time meal presentations on day 3 disrupted this pattern, resulting in a concurrent escalation of DA signal fluctuations upon subsequent VT meal presentations. These findings provide further evidence that, in trained animals, NAcc DA transmission is activated by conditioned incentive cues rather than by primary rewards. They also suggest that the increases in NAcc DA transmission associated with reward expectancy are sensitive to temporal cues (e.g. interval timing) and to discrepancies between expected and actual outcomes. PMID:18513317

  10. Literature survey: Relations between stress change, deformation and transmissivity for fractures and deformation zones based on in situ investigations

    Energy Technology Data Exchange (ETDEWEB)

    Fransson, Aasa (Chalmers Univ. of Technology, Goeteborg (Sweden))

    2009-02-15

    This literature survey is focused upon relations between stress change, deformation and transmissivity for fractures and deformation zones and aims at compiling and commenting on relevant information and references with focus on data from in situ investigations. Main issues to investigate are: - Impact of normal stress change and deformation on transmissivity, for fractures and deformation zones. - Impact of shear stress and displacement on transmissivity, for fractures and deformation zones for different normal load conditions. Considering the line of research within the area, the following steps in the development can be identified. During the 1970's and 1980's, the fundamentals of rock joint deformation were investigated and identification and description of mechanisms were made in the laboratory. In the 1990's, coupling of stress-flow properties of rock joints were made using hydraulic testing to identify and describe the mechanisms in the field. Both individual fractures and deformation zones were of interest. In situ investigations have also been the topic of interest the last ten years. Further identification and description of mechanisms in the field have been made including investigation and description of system of fractures, different types of fractures (interlocked/mated or mismatched/unmated) and how this is coupled to the hydromechanical behavior. In this report, data from in situ investigations are compiled and the parameters considered to be important to link fracture deformation and transmissivity are normal stiffness, k{sub n} and hydraulic aperture, b{sub h}. All data except for those from one site originate from investigations performed in granitic rock. Normal stiffness, k{sub n}, and hydraulic aperture, b{sub h}, are correlated, even though data are scattered. In general, the largest variation is seen for small hydraulic apertures and high normal stiffness. The increasing number of contact points (areas) and fracture filling are

  11. 42 CFR 447.205 - Public notice of changes in Statewide methods and standards for setting payment rates.

    Science.gov (United States)

    2010-10-01

    ... SERVICES Payment Methods: General Provisions § 447.205 Public notice of changes in Statewide methods and standards for setting payment rates. (a) When notice is required. Except as specified in paragraph (b) of... standards for setting payment rates. 447.205 Section 447.205 Public Health CENTERS FOR MEDICARE &...

  12. Changes in Depositional Setting Reflect Rising Sealevel in Latest Holocene Sediments of the Hudson River

    Science.gov (United States)

    Slagle, A.; Carbotte, S. M.; Ryan, W. B.; Bell, R.; Nitsche, F. O.; McHugh, C. M.

    2002-12-01

    An extensive database of geophysical and sampling data in the Hudson River has been obtained in ten study areas between the New York Harbor and the Troy Dam. These data include bathymetry, bank-to-bank coverage of side-looking sonar imagery, subbottom reflection profiles, sediment cores and grabs. Geophysical properties, including gamma density, magnetic susceptibility and P-wave velocity, have been measured in a 9.3 m Vibracore (SD-30) from the near-channel tidal flats of the Tappan Zee area. Three distinct sedimentary facies have been identified, based on changes in physical properties, lithology and seismic reflections. Facies 1 is an oyster-rich unit with unstratified sediments and high sound velocities, and is found in the upper 1.5 m of core SD-30. Chirp subbottom data, which provide reflectors down to approximately 4 m depth, show a distinct horizon at 1.5 m, supporting the change seen in physical property data and lithology at this depth. A unit characterized by laminated sediments, interbedded with homogeneous layers and coquina layers, is identified as Facies 2 and is found between 1.5 and 6.1 m. This facies has high magnetic susceptibility and the appearance of discrete density cycles. The oldest unit, Facies 3, extends from 6.1 m to the base of the core at 9.3 m. It is made up of oyster-rich, unbedded sediments and thick coquina layers, and is characterized by low magnetic susceptibility. Radiocarbon dating of oysters and bivalves indicates that the different facies in SD-30 correspond to different sedimentation rates, with highest values occurring during deposition of Facies 2. The facies changes and variations in sedimentation rates are attributed to an evolving depositional environment in the tidal flats of the Tappan Zee area due to rising sealevel. Extrapolating from nearby cores that penetrate deeper into the sedimentary record, Facies 3 sits above post-glacial fluvial sands and represents the transition from a fresh to more brackish environment

  13. Change of cholinergic transmission and memory deficiency induced by injection of b-amyloid protein into NBM of rats

    Institute of Scientific and Technical Information of China (English)

    马晓峰; 叶惟泠; 梅镇彤

    2001-01-01

    The change of cholinergic transmission of b-amyloid protein (b-AP) treated rats was studied by intracerebral microdialysis sampling combined with HPLC analysis. b-AP1-40 was injected into nucleus basalis magnocellularis (NBM). Passive avoidance response test (step-down test) and delayed alternation task were used for memory testing. The impairment of memory after injection of b-AP1-40 into NBM exhibited mainly the deficiency of short-term working memory. One week after injection of b-AP1-40 the release of acetylcholine (ACh) from frontal cortex of freely-moving rats decreased significantly, and the response of cholinergic nerve ending to the action of high [K+] solution was rather weak. In control animals the percentage of increase of ACh- release during behavioral performance was 57%, while in b-AP1-40 - treated rats it was 34%. The temporary in-crease of the ACh-release of the rat put into a new place was also significantly diminished in b-AP1-40 -treated rats. The results show that the injection of b-AP1-40 into NBM impairs the cholinergic transmission in frontal cortex, and the impairment of cholinergic transmission may be the main cause of the deficit of working memory.

  14. Radiation-induced changes in optical transmission in vitreous semiconductors of the Gex Sb40-x S60 system

    International Nuclear Information System (INIS)

    The influence of γ-irradiation on the optical properties of chalcogenide vitreous semiconductors of the Gex Sb40-x S60 ternary system is studied. It is established that a magnitude of radiation-induced effects in the investigated glasses depends on their chemical composition. It is obtained that maximum γ-induced changes in optical transmission reveal in glasses characterized by the average coordination number Z = 2.67, that is, near the point of the so-called topological phase transition from a two-dimensional to a three-dimensional glass structure

  15. Effects of elevation change on mental stress in high-voltage transmission tower construction workers.

    Science.gov (United States)

    Hsu, Feng-Wen; Lin, Chiuhsiang Joe; Lee, Yung-Hui; Chen, Hung-Jen

    2016-09-01

    High-voltage transmission tower construction is a high-risk operation due to the construction site locations, extreme climatic factors, elevated working surfaces, and narrow working space. To comprehensively enhance our understanding of the psychophysiological phenomena of workers in extremely high tower constructions, we carried out a series of field experiments to test and compare three working surface heights in terms of frequency-domain heart rate variability (HRV) measurements. Twelve experienced male workers participated in this experiment. The dependent variables, namely, heart rate (HR), normalized low-frequency power (nLF), normalized high-frequency power (nHF), and LF-to-HF power ratio (LF/HF), were measured with the Polar RS800CX heart rate monitor. The experimental results indicated that the task workload was similar between working surface heights. Tower construction workers perceived an increased level of mental stress as working surface height increased. PMID:27184317

  16. Optical transmission and laser ablation of pathologically changed eye lens capsule

    Science.gov (United States)

    Gamidov, A. A.; Bolshunov, A. V.; Yuzhakov, A. V.; Shcherbakov, E. M.; Baum, O. I.; Sobol, E. N.

    2015-02-01

    Optical transmission and ablation mechanisms in the secondary cataract films under the impact of 1.06-mm laser radiation are studied. The comparison of incident and transmitted (paraxial) radiation power at different values of the power density is carried out for two types of the eye lens capsule tissue (hard and soft) possessing different optical and mechanical properties. It is found that the effective attenuation coefficient for soft films is almost five times as large as that for the hard ones. The obtained measurement data on the transparency variation in the process of laser action allow the temperature evaluation and the determination of dominant mechanism of laser ablation, as well as the development of recommendations, providing the prevention or reduction of possible side effects. The obtained results can be used to optimise the regimes of laser impact in the process of the opacified lens capsule removal.

  17. Changes in attitude, sexual behaviour and the risk of HIV/AIDS transmission in southwest Nigeria.

    Science.gov (United States)

    Olayinka, B A; Osho, A A

    1997-09-01

    This pilot study was carried out in southwest Nigeria to determine the current trends in sexual behaviours known to be associated with HIV transmission in Nigeria. Knowledge of AIDS in general and as an incurable disease was high (91.4% and 79.4% respectively). Knowledge of the means of AIDS transmission was also very high among both men and women. Overall, condom use was consistent at 25%, inconsistent at 55% and non-existent at 20% for all sexually active respondents. Over 60 per cent of sexually active respondents had two or more sexual partners, with significantly more males than females having this number of sexual partners (p < 0.01). Eighteen per cent of sexually active respondents had a history of sex with commercial sex workers while 25% had a history of at least one sexually transmitted disease. Using multiple logistic regression, the significant determinants of condom use among the sexually active group were: being in a stable sexual relationship, history of sex with commercial sex workers, self-perception of testing positive for HIV and self-perception of HIV/AIDS risk in Nigeria. Prevalence of condom use in this study was much higher than those reported in previous studies, suggesting a probable decline in high risk sexual behaviours among inhabitants of urban Southwest Nigeria since the advent of AIDS. Most sexually active respondents aged 19 years or below (adolescents) who perceived themselves at a high risk of testing positive for HIV had never used condoms. The non usage of condoms among this group of adolescents is disturbing, since they are at greatest risk of spreading the disease. Health education and promotion of safe sex practices need to be extensively targeted at adolescents. PMID:9487429

  18. Age-related changes in visual exploratory behavior in a natural scene setting

    Directory of Open Access Journals (Sweden)

    JohannaHamel

    2013-06-01

    Full Text Available Diverse cognitive functions decline with increasing age, including the ability to process central and peripheral visual information in a laboratory testing situation (useful visual field of view. To investigate whether and how this influences activities of daily life, we studied age-related changes in visual exploratory behavior in a natural scene setting: a driving simulator paradigm of variable complexity was tested in subjects of varying ages with simultaneous eye- and head-movement recordings via a head-mounted camera. Detection and reaction times were also measured by visual fixation and manual reaction. We considered video computer game experience as a possible influence on performance. Data of 73 participants of varying ages were analyzed, driving two different courses. We analyzed the influence of route difficulty level, age and eccentricity of test stimuli on oculomotor and driving behavior parameters. No significant age effects were found regarding saccadic parameters. In the older subjects head-movements increasingly contributed to gaze amplitude. More demanding courses and more peripheral stimuli locations, induced longer reaction times in all age groups. Deterioration of the functionally useful visual field of view with increasing age was not suggested in our study group. However, video game-experienced subjects revealed larger saccade amplitudes and a broader distribution of fixations on the screen. They reacted faster to peripheral objects suggesting the notion of a general detection task rather than perceiving driving as a central task. As the video game experienced population consisted of younger subjects, our study indicates that effects due to video game experience can easily be misinterpreted as age effects if not accounted for. We therefore view it as essential to consider video game experience in all testing methods using virtual media.

  19. Density changes in shear bands of a metallic glass determined by correlative analytical transmission electron microscopy

    International Nuclear Information System (INIS)

    Density changes between sheared zones and their surrounding amorphous matrix as a result of plastic deformation in a cold-rolled metallic glass (melt-spun Al88Y7Fe5) were determined using high-angle annular dark-field (HAADF) detector intensities supplemented by electron-energy loss spectroscopy (EELS), energy-dispersive X-ray (EDX) and nano-beam diffraction analyses. Sheared zones or shear bands were observed as regions of bright or dark contrast arising from a higher or lower density relative to the matrix. Moreover, abrupt contrast changes from bright to dark and vice versa were found within individual shear bands. We associate the decrease in density mainly with an enhanced free volume in the shear bands and the increase in density with concomitant changes of the mass. This interpretation is further supported by changes in the zero loss and Plasmon signal originating from such sites. The limits of this new approach are discussed. - Highlights: • We describe a novel approach for measuring densities in shear bands of metallic glasses. • The linear relation of the dark-field intensity I/I0 and the mass thickness ρt was used. • Individual shear bands showed abrupt contrast changes from bright to dark and vice versa. • Density changes ranging from about −10% to +6% were found for such shear bands. • Mixtures of amorphous/medium range ordered domains were found within the shear bands

  20. Climate, environmental and socio-economic change: weighing up the balance in vector-borne disease transmission.

    Science.gov (United States)

    Parham, Paul E; Waldock, Joanna; Christophides, George K; Hemming, Deborah; Agusto, Folashade; Evans, Katherine J; Fefferman, Nina; Gaff, Holly; Gumel, Abba; LaDeau, Shannon; Lenhart, Suzanne; Mickens, Ronald E; Naumova, Elena N; Ostfeld, Richard S; Ready, Paul D; Thomas, Matthew B; Velasco-Hernandez, Jorge; Michael, Edwin

    2015-04-01

    Arguably one of the most important effects of climate change is the potential impact on human health. While this is likely to take many forms, the implications for future transmission of vector-borne diseases (VBDs), given their ongoing contribution to global disease burden, are both extremely important and highly uncertain. In part, this is owing not only to data limitations and methodological challenges when integrating climate-driven VBD models and climate change projections, but also, perhaps most crucially, to the multitude of epidemiological, ecological and socio-economic factors that drive VBD transmission, and this complexity has generated considerable debate over the past 10-15 years. In this review, we seek to elucidate current knowledge around this topic, identify key themes and uncertainties, evaluate ongoing challenges and open research questions and, crucially, offer some solutions for the field. Although many of these challenges are ubiquitous across multiple VBDs, more specific issues also arise in different vector-pathogen systems. PMID:25688012

  1. Indicators for tracking European vulnerabilities to the risks of infectious disease transmission due to climate change.

    Science.gov (United States)

    Suk, Jonathan E; Ebi, Kristie L; Vose, David; Wint, Willy; Alexander, Neil; Mintiens, Koen; Semenza, Jan C

    2014-02-01

    A wide range of infectious diseases may change their geographic range, seasonality and incidence due to climate change, but there is limited research exploring health vulnerabilities to climate change. In order to address this gap, pan-European vulnerability indices were developed for 2035 and 2055, based upon the definition vulnerability = impact/adaptive capacity. Future impacts were projected based upon changes in temperature and precipitation patterns, whilst adaptive capacity was developed from the results of a previous pan-European study. The results were plotted via ArcGISTM to EU regional (NUTS2) levels for 2035 and 2055 and ranked according to quintiles. The models demonstrate regional variations with respect to projected climate-related infectious disease challenges that they will face, and with respect to projected vulnerabilities after accounting for regional adaptive capacities. Regions with higher adaptive capacities, such as in Scandinavia and central Europe, will likely be better able to offset any climate change impacts and are thus generally less vulnerable than areas with lower adaptive capacities. The indices developed here provide public health planners with information to guide prioritisation of activities aimed at strengthening regional preparedness for the health impacts of climate change. There are, however, many limitations and uncertainties when modeling health vulnerabilities. To further advance the field, the importance of variables such as coping capacity and governance should be better accounted for, and there is the need to systematically collect and analyse the interlinkages between the numerous and ever-expanding environmental, socioeconomic, demographic and epidemiologic datasets so as to promote the public health capacity to detect, forecast, and prepare for the health threats due to climate change. PMID:24566049

  2. Indicators for Tracking European Vulnerabilities to the Risks of Infectious Disease Transmission due to Climate Change

    Directory of Open Access Journals (Sweden)

    Jonathan E. Suk

    2014-02-01

    Full Text Available A wide range of infectious diseases may change their geographic range, seasonality and incidence due to climate change, but there is limited research exploring health vulnerabilities to climate change. In order to address this gap, pan-European vulnerability indices were developed for 2035 and 2055, based upon the definition vulnerability = impact/adaptive capacity. Future impacts were projected based upon changes in temperature and precipitation patterns, whilst adaptive capacity was developed from the results of a previous pan-European study. The results were plotted via ArcGISTM to EU regional (NUTS2 levels for 2035 and 2055 and ranked according to quintiles. The models demonstrate regional variations with respect to projected climate-related infectious disease challenges that they will face, and with respect to projected vulnerabilities after accounting for regional adaptive capacities. Regions with higher adaptive capacities, such as in Scandinavia and central Europe, will likely be better able to offset any climate change impacts and are thus generally less vulnerable than areas with lower adaptive capacities. The indices developed here provide public health planners with information to guide prioritisation of activities aimed at strengthening regional preparedness for the health impacts of climate change. There are, however, many limitations and uncertainties when modeling health vulnerabilities. To further advance the field, the importance of variables such as coping capacity and governance should be better accounted for, and there is the need to systematically collect and analyse the interlinkages between the numerous and ever-expanding environmental, socioeconomic, demographic and epidemiologic datasets so as to promote the public health capacity to detect, forecast, and prepare for the health threats due to climate change.

  3. A vectorial capacity product to monitor changing malaria transmission potential in epidemic regions of Africa

    Science.gov (United States)

    Ceccato, Pietro; Vancutsem, Christelle; Klaver, Robert; Rowland, James; Connor, Stephen J.

    2012-01-01

    Rainfall and temperature are two of the major factors triggering malaria epidemics in warm semi-arid (desert-fringe) and high altitude (highland-fringe) epidemic risk areas. The ability of the mosquitoes to transmit Plasmodium spp. is dependent upon a series of biological features generally referred to as vectorial capacity. In this study, the vectorial capacity model (VCAP) was expanded to include the influence of rainfall and temperature variables on malaria transmission potential. Data from two remote sensing products were used to monitor rainfall and temperature and were integrated into the VCAP model. The expanded model was tested in Eritrea and Madagascar to check the viability of the approach. The analysis of VCAP in relation to rainfall, temperature and malaria incidence data in these regions shows that the expanded VCAP correctly tracks the risk of malaria both in regions where rainfall is the limiting factor and in regions where temperature is the limiting factor. The VCAP maps are currently offered as an experimental resource for testing within Malaria Early Warning applications in epidemic prone regions of sub-Saharan Africa. User feedback is currently being collected in preparation for further evaluation and refinement of the VCAP model.

  4. CHESS-changing horizon efficient set search: A simple principle for multiobjective optimization

    DEFF Research Database (Denmark)

    Borges, Pedro Manuel F. C.

    2000-01-01

    This paper presents a new concept for generating approximations to the non-dominated set in multiobjective optimization problems. The approximation set A is constructed by solving several single-objective minimization problems in which a particular function D(A, z) is minimized. A new algorithm to...

  5. CHESS-changing horizon efficient set search: A simple principle for multiobjective optimization

    DEFF Research Database (Denmark)

    Borges, Pedro Manuel F. C.

    2000-01-01

    This paper presents a new concept for generating approximations to the non-dominated set in multiobjective optimization problems. The approximation set A is constructed by solving several single-objective minimization problems in which a particular function D(A, z) is minimized. A new algorithm t...

  6. Factors enhancing utilization of and adherence to prevention of mother-to-child transmission (PMTCT) service in an urban setting in Kenya.

    Science.gov (United States)

    Murithi, Lydia Karuta; Masho, Saba W; Vanderbilt, Allison A

    2015-04-01

    Despite expansive scale-up of prevention of mother-to-child transmission (PMTCT) of HIV services in Kenya over the last decade, Kenya remains one of the countries contributing to high numbers of children living with HIV globally and is among the 22 PMTCT global plan priority countries. Using structured and in-depth interviews this study examined enabling factors that enhance utilization of and adherence to PMTCT services in an urban setting in Kenya. HIV-positive birthmothers (N = 55) whose infants were HIV-negative at the time of the study completed a structured interview and a subset (n = 15) participated in in-depth interviews. The majority of the mothers (98 %) delivered at a health facility and 91 % exclusively breastfed. Further, 91 % attended clinic appointments regularly and 69.1 % strictly adhered to prescribed medication dosage and schedules. However, 18 % had not disclosed their HIV status to anybody, 27 % did not use condom during sex, 95 % did not participate in AIDS support groups and 53 % of their male partners were not involved in PMTCT. Four key themes facilitating PMTCT success emerged from the qualitative data: supportive counseling, striving for motherhood, assurance of confidentiality; and confirmation, affirmation and admiration. HIV/AIDS related stigma and gender imbalances create many missed opportunities for HIV-positive mothers to reach out for support from family and community, apply acquired knowledge and access more affordable care. To be successful, PMTCT programs should be aware of these factors and ensure that mothers are provided with culturally competent care. PMID:25381562

  7. Expansion of HAART coverage is associated with sustained decreases in HIV/AIDS morbidity, mortality and HIV transmission: the "HIV Treatment as Prevention" experience in a Canadian setting.

    Directory of Open Access Journals (Sweden)

    Julio S G Montaner

    Full Text Available BACKGROUND: There has been renewed call for the global expansion of highly active antiretroviral therapy (HAART under the framework of HIV treatment as prevention (TasP. However, population-level sustainability of this strategy has not been characterized. METHODS: We used population-level longitudinal data from province-wide registries including plasma viral load, CD4 count, drug resistance, HAART use, HIV diagnoses, AIDS incidence, and HIV-related mortality. We fitted two Poisson regression models over the study period, to relate estimated HIV incidence and the number of individuals on HAART and the percentage of virologically suppressed individuals. RESULTS: HAART coverage, median pre-HAART CD4 count, and HAART adherence increased over time and were associated with increasing virological suppression and decreasing drug resistance. AIDS incidence decreased from 6.9 to 1.4 per 100,000 population (80% decrease, p = 0.0330 and HIV-related mortality decreased from 6.5 to 1.3 per 100,000 population (80% decrease, p = 0.0115. New HIV diagnoses declined from 702 to 238 cases (66% decrease; p = 0.0004 with a consequent estimated decline in HIV incident cases from 632 to 368 cases per year (42% decrease; p = 0.0003. Finally, our models suggested that for each increase of 100 individuals on HAART, the estimated HIV incidence decreased 1.2% and for every 1% increase in the number of individuals suppressed on HAART, the estimated HIV incidence also decreased by 1%. CONCLUSIONS: Our results show that HAART expansion between 1996 and 2012 in BC was associated with a sustained and profound population-level decrease in morbidity, mortality and HIV transmission. Our findings support the long-term effectiveness and sustainability of HIV treatment as prevention within an adequately resourced environment with no financial barriers to diagnosis, medical care or antiretroviral drugs. The 2013 Consolidated World Health Organization Antiretroviral

  8. Climate change and parasite transmission: how temperature affects parasite infectivity via predation on infective stages

    NARCIS (Netherlands)

    Goedknegt, M.A.; Welsh, J.E.; Drent, J.; Thieltges, D.W.

    2015-01-01

    Climate change is expected to affect disease risk in many parasite-host systems, e.g., via an effect of temperature on infectivity (temperature effects). However, recent studies indicate that ambient communities can lower disease risk for hosts, for instance via predation on free-living stages of pa

  9. Comparing environmental changes and habitability settings in the geological history of Sahara and Mars

    Science.gov (United States)

    Ori, G. G.; Sabbadini, R.; Komatsu, G.

    2014-12-01

    Sahara has experienced during its long geological history a large number of climatic changes from humid conditions (with savanna-type environments) to dry conditions (with hot desert environments). Therefore, since the late Miocene (?), Sahara experienced periods with rivers, lakes, deltas, and swamps alternated with dry periods with strong aeolian activity and the formation of deflation surface and sand seas. The fluvio-lacustrine deposits formed during humid periods have been strongly reworked by wind processes during the dry periods leaving only the coarse-grained portion of the sediments (conglomerate to rudite). This highly efficient reworking eeolian mechanism affected both of the fluvial and deltaic channel deposits and the large inland lakes, flood plains and other waterlogged areas. The former occurs, at present day, as morphological features and coarse-grained remnants of large fluvial systems whereas the latter are mostly buried below sand seas such as Grand Erg Oriental, Erg Chech, and Azawad. While the sand to silt material accumulated (mostly by saltation) in the sand seas and sand sheets, the finer portion (able to enter the wind as suspended material) was probably swallowed in the large- scale atmospheric circulation redistributed in Sahara itself, in adjacent continents (mostly Europe and South America), and oceans. This geological setting is similar to the one of Mars where fluvial deposits and morphologies abound as largely eroded discontinuous remains. Large-scale alluvial basins and terminal lakes or waterlogged areas (such as the allucial plain in Zephyria) have been largely present in the Martian Noachian-Hesperian time (and possibly even later) but relatively scanty sedimentary deposits testify their existence. When deposits are present they are basically coarse-grained (e.g. the meandering channels of the Eberswalde deltaic plain) due to the long lasting aeolian erosion similarly than the Sahara example. The wind, that dominated the long

  10. An Economic Evaluation of the Posttreatment Prophylactic Effect of Dihydroartemisinin-Piperaquine Versus Artemether-Lumefantrine for First-Line Treatment of Plasmodium falciparum Malaria Across Different Transmission Settings in Africa.

    Science.gov (United States)

    Pfeil, Johannes; Borrmann, Steffen; Bassat, Quique; Mulenga, Modest; Talisuna, Ambrose; Tozan, Yesim

    2015-11-01

    Malaria disproportionately affects young children. Clinical trials in African children showed that dihydroartemisinin-piperaquine (DP) is an effective antimalarial and has a longer posttreatment prophylactic (PTP) effect against reinfections than other artemisinin-based combination therapies, including artemether-lumefantrine (AL). Using a previously developed Markov model and individual patient data from a multicenter African drug efficacy trial, we assessed the economic value of the PTP effect of DP versus AL in pediatric malaria patients from health-care provider's perspective in low-to-moderate and moderate-to-high transmission settings under different drug co-payment scenarios. In low-to-moderate transmission settings, first-line treatment with DP was highly cost-effective with an incremental cost-effectiveness ratio of US$5 (95% confidence interval [CI] = -76 to 196) per disability-adjusted life year (DALY) averted. In moderate-to-high transmission settings, DP first-line treatment led to a mean cost saving of US$1.09 (95% CI = -0.88 to 3.85) and averted 0.05 (95% CI = -0.08 to 0.22) DALYs per child per year. Our results suggested that DP might be superior to AL for first-line treatment of uncomplicated childhood malaria across a range of transmission settings in Africa. PMID:26240155

  11. Impact of Ge-Sb-Te compound engineering on the set operation performance in phase-change memories

    Science.gov (United States)

    Boniardi, Mattia; Ielmini, Daniele; Tortorelli, Innocenzo; Redaelli, Andrea; Pirovano, Agostino; Allegra, Mario; Magistretti, Michele; Bresolin, Camillo; Erbetta, Davide; Modelli, Alberto; Varesi, Enrico; Pellizzer, Fabio; Lacaita, Andrea L.; Bez, Roberto

    2011-04-01

    The phase-change memory (PCM) technology is considered as one of the most attractive non-volatile memory concepts for next generation data storage. It relies on the ability of a chalcogenide material belonging to the Ge-Sb-Te compound system to reversibly change its phase between two stable states, namely the poly-crystalline low-resistive state and the amorphous high-resistive state, allowing the storage of the logical bit. A careful study of the phase-change material properties in terms of the set operation performance, the program window and the electrical switching parameters as a function of composition is very attractive in order to enlarge the possible PCM application spectrum. Concerning the set performance, a crystallization kinetics based interpretation of the observed behavior measured on different Ge-Sb-Te compounds is provided, allowing a physics-based comprehension of the reset-to-set transition.

  12. Pathways of information transmission among wild songbirds follow experimentally imposed changes in social foraging structure

    Science.gov (United States)

    Sheldon, Ben C.

    2016-01-01

    Animals regularly use information from others to shape their decisions. Yet, determining how changes in social structure affect information flow and social learning strategies has remained challenging. We manipulated the social structure of a large community of wild songbirds by controlling which individuals could feed together at automated feeding stations (selective feeders). We then provided novel ephemeral food patches freely accessible to all birds and recorded the spread of this new information. We demonstrate that the discovery of new food patches followed the experimentally imposed social structure and that birds disproportionately learnt from those whom they could forage with at the selective feeders. The selective feeders reduced the number of conspecific information sources available and birds subsequently increased their use of information provided by heterospecifics. Our study demonstrates that changes to social systems carry over into pathways of information transfer and that individuals learn from tutors that provide relevant information in other contexts. PMID:27247439

  13. Biochemical, histopathological, and transmission electron microscopic ultrastructural changes in mice after exposure to silver nanoparticles.

    Science.gov (United States)

    Ansari, Mohammad Azam; Khan, Haris M; Khan, Aijaz A; Alzohairy, Mohammad A; Waseem, Mohammad; Ahmad, Mohammad Kaleem; Mahdi, Abbas Ali

    2016-08-01

    Four-week-old mice, weighing about 25-35 g were divided into five groups (8 mice in each group): vehicle control, low- (0.5 g/kg), middle- (1 g/kg), high- (3 g/kg), and exceptionally high-dose (5 g/kg). After first and second weeks of intraperitoneal exposure to AgNPs, biochemical, histopathological, and electron microscopic ultrastructural changes were investigated. No significant changes were observed in SGOT and ALP levels after first week of exposure, while the level of SGPT significantly increased (p groups of treated mice. However, significant (p groups of treated mice only at high-dose (3 and 5 g/kg). No remarkable changes in lipid profile were observed. Light microscopic histopathological investigation shows that first week treatment had not perceptible effect on the cytoarchitecture on liver, kidney, and spleen; while, second week treatment had only sporadic mild effects on these organs. However, no ultrastructural electron microscopic changes were observed in liver, kidney, and spleen of mice treated with 0.5, 1, and 3 g/kg of AgNPs when sacrificed on first and second week; while, exceptionally high-dose (5 g/kg) of AgNPs resulted in slight nuclear chromatin condensation and irregularities in nuclear membrane. The results suggested that AgNPs could be well tolerated in mice when given intraperitoneally and no death has been found during the experiment in any groups of treated mice. Interestingly, significant (group is suggestive of curious hypoglycemic role of AgNPs warranting further study to explore its possible therapeutic potential in hyperglycemic conditions as well as its mechanism of action at molecular level. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 945-956, 2016. PMID:25648600

  14. Subtle alterations of excitatory transmission are linked to presynaptic changes in the hippocampus of PINK1-deficient mice.

    Science.gov (United States)

    Feligioni, Marco; Mango, Dalila; Piccinin, Sonia; Imbriani, Paola; Iannuzzi, Filomena; Caruso, Alessandra; De Angelis, Francesca; Blandini, Fabio; Mercuri, Nicola B; Pisani, Antonio; Nisticò, Robert

    2016-06-01

    Homozygous or heterozygous mutations in the PTEN-induced kinase 1 (PINK1) gene have been linked to early-onset Parkinson's disease (PD). Several neurophysiological studies have demonstrated alterations in striatal synaptic plasticity along with impaired dopamine release in PINK1-deficient mice. Using electrophysiological methods, here we show that PINK1 loss of function causes a progressive increase of spontaneous glutamate-mediated synaptic events in the hippocampus, without influencing long-term potentiation. Moreover, fluorescence analysis reveals increased neurotrasmitter release although our biochemical results failed to detect which presynaptic proteins might be engaged. This study provides a novel role for PINK1 beyond the physiology of nigrostriatal dopaminergic circuit. Specifically, PINK1 might contribute to preserve synaptic function and glutamatergic homeostasis in the hippocampus, a brain region underlying cognition. The subtle changes in excitatory transmission here observed might be a pathogenic precursor to excitotoxic neurodegeneration and cognitive decline often observed in PD. Using electrophysiological and fluorescence techniques, we demonstrate that lack of PINK1 causes increased excitatory transmission and neurotransmitter release in the hippocampus, which might lead to the cognitive decline often observed in Parkinson's disease. PMID:26850695

  15. Ready, Set, Change! Development and usability testing of an online readiness for change decision support tool for healthcare organizations

    OpenAIRE

    Timmings, Caitlyn; Khan, Sobia; Moore, Julia E; Marquez, Christine; Pyka, Kasha; Straus, Sharon E

    2016-01-01

    Background To address challenges related to selecting a valid, reliable, and appropriate readiness assessment measure in practice, we developed an online decision support tool to aid frontline implementers in healthcare settings in this process. The focus of this paper is to describe a multi-step, end-user driven approach to developing this tool for use during the planning stages of implementation. Methods A multi-phase, end-user driven approach was used to develop and test the usability of a...

  16. Changing malaria transmission and implications in China towards National Malaria Elimination Programme between 2010 and 2012.

    Directory of Open Access Journals (Sweden)

    Jian-hai Yin

    Full Text Available BACKGROUND: Towards the implementation of national malaria elimination programme in China since 2010, the epidemiology of malaria has changed dramatically, and the lowest malaria burden was achieved yearly. It is time to analyze the changes of malaria situation based on surveillance data from 2010 to 2012 to reconsider the strategies for malaria elimination. METHODS AND PRINCIPAL FINDINGS: Malaria epidemiological data was extracted from the provincial annual reports in China between 2010 and 2012. The trends of the general, autochthonous and imported malaria were analyzed, and epidemic areas were reclassified according to Action Plan of China Malaria Elimination (2010-2020. As a result, there reported 2743 malaria cases with a continued decline in 2012, and around 7% autochthonous malaria cases accounted. Three hundred and fifty-three individual counties from 19 provincial regions had autochthonous malaria between 2010 and 2012, and only one county was reclassified into Type I (local infections detected in 3 consecutive years and the annual incidences ≥ 1/10,000 again. However, the imported malaria cases reported of each year were widespread, and 598 counties in 29 provinces were suffered in 2012. CONCLUSIONS/SIGNIFICANCE: Malaria was reduced significantly from 2010 to 2012 in China, and malaria importation became an increasing challenge. It is necessary to adjust or update the interventions for subsequent malaria elimination planning and resource allocation.

  17. Climate Change Education in Formal Settings, K-14: A Workshop Summary

    Science.gov (United States)

    Beatty, Alexandra

    2012-01-01

    Climate change is occurring, is very likely caused by human activities, and poses significant risks for a broad range of human and natural systems. Each additional ton of greenhouse gases emitted commits us to further change and greater risks. In the judgment of the Committee on America's Climate Choices, the environmental, economic, and…

  18. Predicting Plausible Impacts of Sets of Climate and Land Use Change Scenario on Water Resources

    Science.gov (United States)

    As the new decade ushers in, there will be new challenges. The world’s population is increasing and the land use patterns are changing. Inevitably with these global changes, there will be various environmental consequences. For example, our water resources, both in terms of qu...

  19. A coherent set of future land use change scenarios for Europe

    DEFF Research Database (Denmark)

    Rounsevell, M. D. A.; Reginster, I.; Araújo, Miguel B.;

    2006-01-01

    most striking for the agricultural land uses, with large area declines resulting from assumptions about future crop yield development with respect to changes in the demand for agricultural commodities. Abandoned agricultural land is a consequence of these assumptions. Increases in urban areas (arising......This paper presents a range of future, spatially explicit, land use change scenarios for the EU15, Norway and Switzerland based on an interpretation of the global storylines of the Intergovernmental Panel on Climate Change (IPCC) that are presented in the special report on emissions scenarios (SRES......). The methodology is based on a qualitative interpretation of the SRES storylines for the European region, an estimation of the aggregate totals of land use change using various land use change models and the allocation of these aggregate quantities in space using spatially explicit rules. The spatial...

  20. An Example of How to Supplement Goal Setting to Promote Behavior Change for Families Using Motivational Interviewing.

    Science.gov (United States)

    Draxten, Michelle; Flattum, Colleen; Fulkerson, Jayne

    2016-10-01

    The purpose of this study was to describe the components and use of motivational interviewing (MI) within a behavior change intervention to promote healthful eating and family meals and prevent childhood obesity. The Healthy Home Offerings via the Mealtime Environment (HOME) Plus intervention was part of a two-arm randomized-controlled trial and included 81 families (children 8-12 years old and their parents) in the intervention condition. The intervention included 10 monthly, 2-hour group sessions and 5 bimonthly motivational/goal-setting phone calls. Data were collected for intervention families only at each of the goal-setting calls and a behavior change assessment was administered at the 10th/final group session. Descriptive statistics were used to analyze the MI call data and behavior assessment. Overall group attendance was high (68% attending ≥7 sessions). Motivational/goal-setting phone calls were well accepted by parents, with an 87% average completion rate. More than 85% of the time, families reported meeting their chosen goal between calls. Families completing the behavioral assessment reported the most change in having family meals more often and improving home food healthfulness. Researchers should use a combination of delivery methods using MI when implementing behavior change programs for families to promote goal setting and healthful eating within pediatric obesity interventions. PMID:26940585

  1. Co-registration and bias corrections of satellite elevation data sets for quantifying glacier thickness change

    OpenAIRE

    Nuth, C.; Kääb, A.

    2011-01-01

    There are an increasing number of digital elevation models (DEMs) available worldwide for deriving elevation differences over time, including vertical changes on glaciers. Most of these DEMs are heavily post-processed or merged, so that physical error modelling becomes difficult and statistical error modelling is required instead. We propose a three-step methodological framework for assessing and correcting DEMs to quantify glacier elevation changes: (i) remove DEM shifts, (ii) check for elev...

  2. Setting the Agenda : The Scope to Act on Climate Change Interests for Chinese NGOs

    OpenAIRE

    2012-01-01

    The Chinese state and society are frequently engaged in an area of mutual concern: the increasing threat of climate change. The state is approaching this concern by directing China’s development towards a low-carbon economy, where the aim is to reduce the greenhouse gas emissions without limiting economic growth. Societal actors such as social organisations started emerging in China in the 1980s and are to a further extent than before interacting politically with state matters, climate change...

  3. Standardized Baseline Setting Methodology for Energy Improvement Projects in the International Climate Change Policy

    OpenAIRE

    HARUO IMAI; Jiro Akita; Hidenori Niizawa

    2013-01-01

    The Target is to examine new method of setting baseline for Clean Development Mechanism proposed by the CDM-EB at UN. The proposal is to reduce transaction costs so that projects in smaller countries can be supported and focus is placed more on energy efficiency projects.Stuies are based on documentations issued by the CDM office at UN. BUilding upon empirical findings, with a reference to previous literature, a utilization of economic theory, especially those related to incentive and mechani...

  4. Prevention of mother-to-child HIV transmission in resource-limited settings: assessment of 99 Viramune Donation Programmes in 34 countries, 2000–2011

    OpenAIRE

    Ladner, Joël; Besson, Marie-Hélène; Rodrigues, Mariana; Sams, Kelley; Audureau, Etienne; Saba, Joseph

    2013-01-01

    Background Transmission of HIV from mother-to-child during pregnancy, labor, or breastfeeding is the primary cause of pediatric HIV infection in sub-Saharan Africa. A regimen of single-dose nevirapine administered to both HIV-positive pregnant women and their infants has been shown to lower the risk of mother-to-child transmission (MTCT) of HIV. In an effort to facilitate scale-up of PMTCT programs in low-income countries, Boehringer Ingelheim, the manufacturer of Viramune (branded nevirapine...

  5. Predictors of Staff Turnover and Turnover Intentions within Addiction Treatment Settings: Change Over Time Matters.

    Science.gov (United States)

    Garner, Bryan R; Hunter, Brooke D

    2014-01-01

    This study examined the extent to which changes over time in clinicians' responses to measures of work attitude (eg, job satisfaction) and psychological climate (eg, supervisor support) could predict actual turnover and turnover intentions above and beyond absolute levels of these respective measures. Longitudinal data for this study were collected from a sample of clinicians (N = 96) being trained to implement an evidence-based treatment for adolescent substance use disorders. Supporting findings from a recent staff turnover study, we found job satisfaction change was able to predict actual turnover above and beyond average levels of job satisfaction. Representing new contributions to the staff turnover literature, we also found that change over time in several other key measures (eg, job satisfaction, role manageability, role clarity) explained a significant amount of variance in turnover intentions above and beyond the absolute level of each respective measure. A key implication of the current study is that organizations seeking to improve their ability to assess risk for staff turnover may want to consider assessing staff at multiple points in time in order to identify systematic changes in key employee attitudes like turnover intentions and job satisfaction. PMID:25336960

  6. Changes in Language Development among Autistic and Peer Children in Segregated and Integrated Preschool Settings.

    Science.gov (United States)

    Harris, Sandra L.; And Others

    1990-01-01

    A study of five autistic children in a segregated preschool, five mainstreamed autistic children, and four nonhandicapped, integrated peers found that all of the groups made better than normative progress in language development. There were no significant differences in changes in language ability between segregated and mainstreamed autistic…

  7. Task-specific effects of tDCS-induced cortical excitability changes on cognitive and motor sequence set shifting performance.

    Directory of Open Access Journals (Sweden)

    Jorge Leite

    Full Text Available In this study, we tested the effects of transcranial Direct Current Stimulation (tDCS on two set shifting tasks. Set shifting ability is defined as the capacity to switch between mental sets or actions and requires the activation of a distributed neural network. Thirty healthy subjects (fifteen per site received anodal, cathodal and sham stimulation of the dorsolateral prefrontal cortex (DLPFC or the primary motor cortex (M1. We measured set shifting in both cognitive and motor tasks. The results show that both anodal and cathodal single session tDCS can modulate cognitive and motor tasks. However, an interaction was found between task and type of stimulation as anodal tDCS of DLPFC and M1 was found to increase performance in the cognitive task, while cathodal tDCS of DLPFC and M1 had the opposite effect on the motor task. Additionally, tDCS effects seem to be most evident on the speed of changing sets, rather than on reducing the number of errors or increasing the efficacy of irrelevant set filtering.

  8. Merchant Transmission Investment

    OpenAIRE

    Joskow, Paul L.; Tirole, Jean

    2003-01-01

    We examine the performance attributes of a merchant transmission investment framework that relies on ?market driven? transmission investment to provide the infrastructure to support competitive wholesale markets for electricity. Under a stringent set of assumptions, the merchant investment model appears to solve the natural monopoly problem and the associated need for regulating transmission companies traditionally associated with electric transmission networks. We expand the model to inc...

  9. Simulated Benefits of Green Infrastructure for Urban Stormwater Management under Climate Change in Different Hydroclimatic and Archetypal Urban Settings

    Science.gov (United States)

    Johnson, T. E.; Butcher, J.; Sarkar, S.; Clark, C.

    2015-12-01

    Climate change could significantly alter the occurrence and management of urban stormwater runoff quantity and quality. Responding to this challenge requires an improved understanding of potential changes together with the effectiveness of management responses for reducing impacts under range of potential future climatic conditions. Traditional gray stormwater infrastructure generally uses single-purpose, hard structures including detention basins and storm sewers to dispose of rainwater. Green infrastructure (GI) uses vegetation and soil to manage rainwater where it falls. GI has been gaining in popularity, and has been shown to provide a number of benefits for adapting to climate change including effects on stormwater quantity, quality and carbon and nutrient biogeochemical cycling. Uncertainty remains, however, due to limited understanding of GI performance in different hydroclimatic and urban settings, and in response to changes in climate. In this study we use simulation modeling to assess the impacts of climate change on both gray (wet ponds) and green infrastructure practices (green roofs, swales, bioretention) in different hydroclimatic and urban settings. Simulations were conducted using RHESSYs, a mechanistic, hydrologic and biogeochemical model, for 36 characteristic urban "archetypes" (AUSs) representing different development patterns and GI practices found in typical U.S. cities. Climate change scenarios are based on dynamically and temporally downscaled, mid-21st century climate model output from the North American Regional Climate Change Assessment Program (NARCCAP). Results suggest altered mass and energy inputs will cause changes in performance of these practices for water quantity, water quality, and carbon sequestration that vary across the country. Infrastructure design should take these potential changes into consideration.

  10. Predictors of Staff Turnover and Turnover Intentions within Addiction Treatment Settings: Change Over Time Matters

    OpenAIRE

    Garner, Bryan R.; Hunter, Brooke D.

    2014-01-01

    This study examined the extent to which changes over time in clinicians’ responses to measures of work attitude (eg, job satisfaction) and psychological climate (eg, supervisor support) could predict actual turnover and turnover intentions above and beyond absolute levels of these respective measures. Longitudinal data for this study were collected from a sample of clinicians (N = 96) being trained to implement an evidence-based treatment for adolescent substance use disorders. Supporting fin...

  11. Developing a mental health care plan in a low resource setting: the theory of change approach.

    OpenAIRE

    Hailemariam, M; Fekadu, A.; Selamu, M; Alem, A.; Medhin, G; Giorgis, TW; DeSilva, M.; Breuer, E

    2015-01-01

    Background Scaling up mental healthcare through integration into primary care remains the main strategy to address the extensive unmet mental health need in low-income countries. For integrated care to achieve its goal, a clear understanding of the organisational processes that can promote and hinder the integration and delivery of mental health care is essential. Theory of Change (ToC), a method employed in the planning, implementation and evaluation of complex community initiatives, is an i...

  12. Series Transmission Line Transformer

    Science.gov (United States)

    Buckles, Robert A.; Booth, Rex; Yen, Boris T.

    2004-06-29

    A series transmission line transformer is set forth which includes two or more of impedance matched sets of at least two transmissions lines such as shielded cables, connected in parallel at one end ans series at the other in a cascading fashion. The cables are wound about a magnetic core. The series transmission line transformer (STLT) which can provide for higher impedance ratios and bandwidths, which is scalable, and which is of simpler design and construction.

  13. A Set-Up of 7 Laser Triangulation Sensors and a Draw-Wire Sensor for Measuring Relative Displacement of a Piston Rod Mechanical Lead-Through Transmission in an Offshore Wave Energy Converter on the Ocean Floor

    OpenAIRE

    E. Strömstedt; Svensson, O.; Leijon, M

    2012-01-01

    A concept for offshore wave energy conversion is being developed at the Swedish Centre for Renewable Electric Energy Conversion at Uppsala University in Sweden. The wave energy converter (WEC) in focus contains a piston rod mechanical lead-through transmission for transmitting the absorbed mechanical wave energy through the generator capsule wall while preventing seawater from entering the capsule. A set-up of 7 laser triangulation sensors has been installed inside the WEC to measure relative...

  14. Extended oil-change and oil-filter-change intervals for DOD 5- to 200-kilowatt DED generator sets. Final report 1972-1977

    Energy Technology Data Exchange (ETDEWEB)

    Gurski, C.R.; Fitzgibbons, E.; Dreger, J.W.

    1978-03-01

    The in-house investigation described was to determine whether the industry- and military-standard oil-change interval of 100 hours could be extended for the DOD Family of Diesel Engine Driven Generator Sets using MIL-L-2104C specification lubricating oil. The investigation was conducted in two phases. In Phase I, the oil and filter were changed each 100 hours in accordance with the servicing and maintenance guide specified for the preproduction model 5,000-hour reliability and acceptance tests. In Phase II, the oil-change and filter-change intervals were established by the condition of the oil. The condition of the oil was monitored by chemical and spectrometric analyses. Based on the test results and the urgency of the current energy crisis, the Project Manager, Mobile Electric Power, issued an oil-change policy for the 15-through 200-kW size generator sets directing that the oil and oil filters be changed each 300 hours of engine running (normal running conditions) or after 6 months whichever comes first.

  15. Changing U.S. Ocean Policy Can Set a New Direction for Marine Resource Management

    Directory of Open Access Journals (Sweden)

    Andrew A. Rosenberg

    2009-12-01

    Full Text Available A central concept in a new direction for ocean policy in the United States is ecosystem-based management, that is, implementation of management integrated across sectors of human activity to achieve the common goal of conserving the structure and function of marine ecosystems to provide a full suite of ecosystem services. Fisheries are a critical sector of ocean activity that impacts these ecosystems, and fishery management is in urgent need of reform to perform better from a conservation perspective. Here, I suggest some specific changes in perspective for fishery management as part of an overall ecosystem-based approach.

  16. Electrocardiographic Changes in Certain Cardiovascular Physiological and Pathological Settings. Impact on Coronary Artery Bypass Grafting

    Directory of Open Access Journals (Sweden)

    Dimitar Simov

    2016-03-01

    Full Text Available Review on electrocardiographic changes provoked by aging, diagnostic tests, cardiac surgery, hemodialysis, diabetes, etc., is the objective of the current material. Several electrocardiographic (ECG parameters that are well known risk markers of arrhythmias, incidental heart failure and sudden cardiac death (SCD are discussed: QRS amplitude, QRS morphology, QRS duration, QRS alternans, T-wave amplitude, T-wave morphology, T-wave alternans, negative T-waves, 3D-spatial angle between maximal QRS and T vectors of the vectorcardiographic loops, ST-segment elevation, QT-interval dispersion, and heart rate. All reviewed parameters are compared with the results on the ECG-alterations, induced by coronary artery bypass grafting (CABG surgery. Two parameters showed an improvement in the patients' condition: QRS-T angle and cardiac autonomic innervation while two others (T-wave alternans and heart rate indicated deterioration. We tend to assume that the deterioration in this early post-operative period is an effect of the post-surgery trauma. We speculate that this effect will fade away in a period of a month and more after surgery, and we intend to conduct such a research in the future. The analysis of ECG's changes will help to better assess the impact of the CABG surgery.

  17. Methamphetamine, morphine, and their combination: acute changes in striatal dopaminergic transmission evaluated by microdialysis in awake rats.

    Science.gov (United States)

    Pereira, Frederico C; Lourenço, Elita; Milhazes, Nuno; Morgadinho, Teresa; Ribeiro, Carlos F; Ali, Syed F; Macedo, Tice R

    2006-08-01

    The co-administration of methamphetamine (METH) and MOR (MOR)-like compounds is becoming increasingly popular among drug abusers. Recently, it was demonstrated that rats would self-inject METH-heroin combination and that this combination produced a greater rewarding effect than the identical doses of METH alone and it was further suggested that enhanced reward might underlie the popularity of this combination. However, there is null information on the effects of the MOR-METH combination on striatal dopaminergic transmission. In the present article, in vivo brain microdialysis was used to examine the effects of two METH doses (1 and 5 mg/kg, i.p.; [METH1: hyperlocomotion-inducing] and [METH5: stereotypy-inducing], respectively) and MOR (10 mg/kg, i.p. [MOR10]) either alone or in combination on dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) release in caudate putamen (CPu) in freely moving rats. METH1 evoked a transient threefold increase in DA overflow in only one-third of dosed rats. On the contrary, METH5 elicited a 11-fold increase in the extracellular DA levels 30 min after dosing and stayed significantly (P < 0.05) above control levels up to 1.5 h. On the other hand, MOR10 did not significantly change DA extracellular levels. MOR10-METH1 combination prolonged DA outflow for 1 h in all rats dosed without changing peak effect compared to METH1. On the other hand, MOR10-METH5 combination did not change the peak effect nor the DA outflow profile compared to METH5 alone. Consistently, there is a concentration-dependent decrease in DOPAC efflux evoked by METH: METH1 evoked a smaller decrease in DOPAC outflow showing a tendency for returning to basal values whereas METH5 kept DOPAC extracellular levels reduced throughout the experiment. Again, MOR10 did not significantly change DOPAC extracellular levels. MOR delayed the onset without changing METH effect on the DOPAC output. These findings provide suggestive evidence that MOR potentiated the increase in

  18. NASA's Global Change Master Directory: Discover and Access Earth Science Data Sets, Related Data Services, and Climate Diagnostics

    Science.gov (United States)

    Aleman, Alicia; Olsen, Lola; Ritz, Scott; Morahan, Michael; Cepero, Laurel; Stevens, Tyler

    2011-01-01

    NASA's Global Change Master Directory provides the scientific community with the ability to discover, access, and use Earth science data, data-related services, and climate diagnostics worldwide. The GCMD offers descriptions of Earth science data sets using the Directory Interchange Format (DIF) metadata standard; Earth science related data services are described using the Service Entry Resource Format (SERF); and climate visualizations are described using the Climate Diagnostic (CD) standard. The DIF, SERF and CD standards each capture data attributes used to determine whether a data set, service, or climate visualization is relevant to a user's needs. Metadata fields include: title, summary, science keywords, service keywords, data center, data set citation, personnel, instrument, platform, quality, related URL, temporal and spatial coverage, data resolution and distribution information. In addition, nine valuable sets of controlled vocabularies have been developed to assist users in normalizing the search for data descriptions. An update to the GCMD's search functionality is planned to further capitalize on the controlled vocabularies during database queries. By implementing a dynamic keyword "tree", users will have the ability to search for data sets by combining keywords in new ways. This will allow users to conduct more relevant and efficient database searches to support the free exchange and re-use of Earth science data. http://gcmd.nasa.gov/

  19. Effectiveness of Behavior Change Communications for Reducing Transmission Risks Among People Living with HIV in 6 Countries in Central America.

    Science.gov (United States)

    Vu, Lung; Nieto-Andrade, Benjamin; DiVincenzo, Allison; Rivas, Jorge; Firestone, Rebecca; Wheeler, Jennifer; Lungo, Sussy

    2015-07-01

    This first region-wide study (N = 2,818) aims to estimate prevalence of HIV-related risks (sexual behavior, HIV disclosure, number of sex partners, violence) and factors associated with these risks as well as evaluate a behavior change communications program targeted to PLHIV in 6 countries in Central America. After 2 years, the program achieved moderate coverage, with 21 % of the sample reporting exposure to interpersonal communications (IPC) and 52 % to mass media program components. The odds of condom use, HIV disclosure, and participation in a self-help group increased by 1.4-1.8 times with exposure to mass media. Exposure to IPC increased odds of condom use by 2.7 and participation in self-help groups by 4.4 times. In addition, being in HIV care or taking ART was associated with condom use and HIV-status disclosure. About 30 % experienced physical or sexual violence, and those who did were 4 times less likely to use condoms. Findings suggest that behavioral interventions for PLHIV can reduce HIV-transmission risks and increase access to care. PMID:25284460

  20. Sero-epidemiological evaluation of changes in Plasmodium falciparum and Plasmodium vivax transmission patterns over the rainy season in Cambodia

    DEFF Research Database (Denmark)

    Cook, Jackie; Speybroeck, Nico; Sochanta, Tho;

    2012-01-01

    In Cambodia, malaria transmission is low and most cases occur in forested areas. Sero-epidemiological techniques can be used to identify both areas of ongoing transmission and high-risk groups to be targeted by control interventions. This study utilizes repeated cross-sectional data to assess the...

  1. Reliability and sensitivity to change of the OMERACT rheumatoid arthritis magnetic resonance imaging score in a multireader, longitudinal setting

    DEFF Research Database (Denmark)

    Haavardsholm, ea; Østergaard, Mikkel; Kvan, NP;

    2005-01-01

    OBJECTIVE: To assess the intra- and interreader reliability and the sensitivity to change of the Outcome Measures in Rheumatology Clinical Trials (OMERACT) Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) system on digital images of the wrist joints of patients with early or...... established rheumatoid arthritis (RA). METHODS: Ten sets of baseline and 1-year followup MR images of the wrists of patients with progressive changes on conventional hand radiographs were scored independently by 4 readers on 2 consecutive days, preceded by reader training and calibration. The MR images were...... acquired and scored according to the recommendations from the OMERACT MRI group. The intra- and interreader agreement (evaluated by intraclass correlation coefficients [ICCs]) and the sensitivity to change (evaluated by the smallest detectable difference [SDD]) were determined for scores of synovitis...

  2. Negative effects of land-use changes in the karst setting of Apulia, southern Italy

    Science.gov (United States)

    Parise, Mario

    2010-05-01

    machineries, and favoured by discutable policy of subsidies from the European Community, stone clearing was intensively performed. Wide sectors of Apulia were affected by land use changes, resulting in destruction of the epikarst (Williams, 2008), and of the karst ecosystems therein present as well, through removal of the stones, even of large size, crushing and production of a gravel-size field where to establish crops such as wheat or vineyards. Loss of the natural karst landscape had therefore to be registered over wide territories in the region (Parise & Pascali, 2003). In addition, removal of the original soil had as direct consequence an increase in the erosional processes on the occasion of the main rainstorms, even at those sites characterized by low to very low gradients. Stones of larger size were often piled near cave entrances, or dumped into caves and swallow holes, thus producing a serious danger to cavers, and sometimes impeding the access to important karst caves. All the above changes resulted in heavy degradation of karst, and especially promoted severe erosion in many areas of the region. In some cases, formation of erosional features combined to persistent droughts, thus developing a tendency toward desertification (Sharma, 1998), as already observed in other areas of the Mediterranean basin (Yair, 1983; Atalay, 1999; Geeson et alii, 2002). References Atalay I. (1999) Land use in the karstic lands in the Mediterranean region. Int. J. Speleol., vol. 26B(1/4), p. 111-118. Geeson N.A., Brandt C.J. & Thornes J.B. (Eds.) (2002) Mediterranean desertification. John Wiley & Sons, 440 pp. Parise M. & Pascali V. (2003) Surface and subsurface environmental degradation in the karst of Apulia (southern Italy). Environmental Geology, vol. 44, p. 247-256. Sharma K.D. (1998) The hydrologic indicators of desertification. J. Arid Environ., vol. 39, p. 121-132. Williams P.W. (2008) The role of the epikarst in karst and cave hydrogeology: a review. International Journal of

  3. Changes in the Daphnia magna midgut upon ingestion of copper oxide nanoparticles: a transmission electron microscopy study.

    Science.gov (United States)

    Heinlaan, Margit; Kahru, Anne; Kasemets, Kaja; Arbeille, Brigitte; Prensier, Gérard; Dubourguier, Henri-Charles

    2011-01-01

    This work is a follow-up of our previous paper (Heinlaan et al., 2008. Chemosphere 71, 1308-1316) where we showed about 50-fold higher acute toxicity of CuO nanoparticles (NPs) compared to bulk CuO to water flea Daphnia magna. In the current work transmission electron microscopy (TEM) was used to determine potential time-dependent changes in D. magna midgut epithelium ultrastructure upon exposure to CuO NPs compared to bulk CuO at their 48 h EC(50) levels: 4.0 and 175 mg CuO/L, respectively. Special attention was on potential internalization of CuO NPs by midgut epithelial cells. Ingestion of both CuO formulations by daphnids was evident already after 10 min of exposure. In the midgut lumen CuO NPs were dispersed whereas bulk CuO was clumped. By the 48th hour of exposure to CuO NPs (but not to equitoxic concentrations of bulk CuO) the following ultrastructural changes in midgut epithelium of daphnids were observed: protrusion of epithelial cells into the midgut lumen, presence of CuO NPs in circular structures analogous to membrane vesicles from holocrine secretion in the midgut lumen. Implicit internalization of CuO NPs via D. magna midgut epithelial cells was not evident however CuO NPs were no longer contained within the peritrophic membrane but located between the midgut epithelium microvilli. Interestingly, upon exposure to CuO NPs bacterial colonization of the midgut occurred. Ultrastructural changes in the midgut of D. magna upon exposure to CuO NPs but not to bulk CuO refer to its nanosize-related adverse effects. Time-dependent solubilisation of CuO NPs and bulk CuO in the test medium was quantified by recombinant Cu-sensor bacteria: by the 48th hour of exposure to bulk CuO, the concentration of solubilised copper ions was 0.05 ± 0.01 mg Cu/L that was comparable to the acute EC(50) value of Cu-ions to D. magna (48 h CuSO(4) EC(50) = 0.07 ± 0.01 mg Cu/L). However, in case of CuO NPs, the solubilised Cu-ions 0.01 ± 0.001 mg Cu/L, explained only part of

  4. Modeling approaches to detect land-use changes: Urbanization analyzed on a set of 43 US catchments

    Science.gov (United States)

    Salavati, Bahar; Oudin, Ludovic; Furusho-Percot, Carina; Ribstein, Pierre

    2016-07-01

    Paired catchment approach probably provides the most robust method to detect the effects of land-use change on catchments' flow characteristics. This approach is limited by the availability of two neighbor catchments with and without land-use change under similar climate conditions. This paper uses a hydrological model to detect the hydrological change caused by urbanization. This study describes (1) use a statistical method to evaluate change detection relative to variation of land use change, (2) simulation of non-urban condition for the urban catchment with an alternative approach, to this aim stream flow series of urban catchments have been reconstructed from the period that urbanization had not taken place yet, and (3) the model validation with observed data. This paper intends to compare the flow changes detected by two different approaches: a regional statistical approach (the paired-catchment approach) and a conceptual modeling approach (the residual approach) on the particular case of urbanized catchments. To investigate the sensitivity of the results to the settings of both approaches, the comparison is made on a relatively large number of 43 catchments located in the United States, with relatively large gradients in terms of geomorphology and hydroclimatic characteristics. Results show that the two approaches are generally in relative good agreement in terms of detection and quantification of changes for the three flow characteristics analyzed (mean annual flow, high and low flow characteristics). Besides, it is found that the impact of urbanization on the catchment's hydrologic response is difficult to generalize: the proportion of nonsignificant trends, significantly increasing decreasing trends are on the same order of magnitude, even if an increase in urban areas generally has a greater impact on mean flows and high flows than on low flows.

  5. Effect of JFS set changes (JNC's Response to Action 4.3 in the 4th CRP Meeting)

    International Nuclear Information System (INIS)

    In the analysis of the present IAEA CRP, JNC used the Japanese standard 70-group constant set for fast reactors, JFS-3-J3.2, which was based on the Japanese evaluated nuclear data library, JENDL-3.2., generated and released by JAERI in 1995. Recently, JNC found that two errors were included in the procedure to generate the original JFS set. The major error was the mistreatment of the weighting function to process the group-wise constants from JENDL. The effect of this error was found to make the neutron spectrum of the calculated core too hard. Other minor error was related to the energy distribution of the secondary neutron by the inelastic and (n,2n) scattering reaction. The effect of the second error was found to make the neutron spectrum a little too soft, and somewhat to relieve the effect of the first error. In 2002, JNC generated and released a revised version of JFS set based on JENDL-3.2, named JFS-3-J3.2R, which has corrected the above problems. In the present IAEA CRP, JNC used the JFS-3-J3.2 in Phase 1, 2 and 3, and changed it to JFS-3-J3.2R from Phase 4. This report estimates the effect of the JFS change in Phase 1, 2 and 3. Main conclusions are: (1) The criticality was decreased by 0.2 - 0.3% dk; (2) The absolute value of the fuel Doppler reactivity increased by 8 - 9%; (3) For other core parameters, the effects of cross-section change were not so significant; (4) The increase of neutron lifetime by 3% can be considered as the evidence of the spectrum softening by the cross-section change. The paper includes the results for Phase 3: homogeneous burnup model, the influence to burnup reactivity by JFS change is not significant. Summarized results for Phase 3: EOC of homogeneous model show that the effect on criticality and fuel Doppler reactivity was almost the same as in Phase 1 and 2. On the other hand, the effect to sodium density reactivity was quite emphasized since the energy cancellation was not balanced like in Phase 1 and 2. The result for

  6. What's in an elevation difference? Accuracy and corrections of satellite elevation data sets for quantification of glacier changes

    Science.gov (United States)

    Nuth, C.; Kääb, A.

    2010-10-01

    There is an increasing number of DEMs available worldwide for deriving elevation differences over time, including vertical changes on glaciers. Most of these DEMs are heavily post-processed or merged, so that physical error modelling becomes impossible and statistical error modelling is required instead. We propose a three-step methodological framework for assessing and correcting DEMs to quantify glacier elevation changes: remove DEM shifts, check for elevation-dependent biases, and check for higher-order, sensor-specific biases. An analytic, simple and robust method to co-register elevation data is presented in regions where stable terrain is either plentiful (case study New Zealand) or limited (case study Svalbard). The method is exemplified using the three global elevation data sets available, SRTM, ICESat and the ASTER GDEM, and with automatically generated DEMs from satellite stereo instruments of ASTER and SPOT5-HRS. After three-dimensional co-registration, significant biases related to elevation were found in some of the stereoscopic DEMs. Biases related to the satellite acquisition geometry (along/cross track) were detected at two frequencies in the automatically generated ASTER DEMs. The higher frequency bias seems to be related to satellite emph{jitter}, most effective in the back-looking pass of the satellite. The origins of the more significant lower frequency bias is uncertain. ICESat-derived elevations are found to be the most consistent globally available elevation data set available so far. Before performing regional-scale glacier elevation change studies or mosaicking DEMs from multiple individual tiles (e.g. ASTER GDEM), we recommend to co-register all elevation data to ICESat as a global vertical reference system. The proposed methodological framework is exemplified for elevation changes on the Fox, Franz Joseph, Tasman and Murchison glaciers of New Zealand and the glaciers of central Spitsbergen, Svalbard.

  7. What's in an elevation difference? Accuracy and corrections of satellite elevation data sets for quantification of glacier changes

    Directory of Open Access Journals (Sweden)

    C. Nuth

    2010-10-01

    Full Text Available There is an increasing number of DEMs available worldwide for deriving elevation differences over time, including vertical changes on glaciers. Most of these DEMs are heavily post-processed or merged, so that physical error modelling becomes impossible and statistical error modelling is required instead. We propose a three-step methodological framework for assessing and correcting DEMs to quantify glacier elevation changes: remove DEM shifts, check for elevation-dependent biases, and check for higher-order, sensor-specific biases. An analytic, simple and robust method to co-register elevation data is presented in regions where stable terrain is either plentiful (case study New Zealand or limited (case study Svalbard. The method is exemplified using the three global elevation data sets available, SRTM, ICESat and the ASTER GDEM, and with automatically generated DEMs from satellite stereo instruments of ASTER and SPOT5-HRS. After three-dimensional co-registration, significant biases related to elevation were found in some of the stereoscopic DEMs. Biases related to the satellite acquisition geometry (along/cross track were detected at two frequencies in the automatically generated ASTER DEMs. The higher frequency bias seems to be related to satellite emph{jitter}, most effective in the back-looking pass of the satellite. The origins of the more significant lower frequency bias is uncertain. ICESat-derived elevations are found to be the most consistent globally available elevation data set available so far. Before performing regional-scale glacier elevation change studies or mosaicking DEMs from multiple individual tiles (e.g. ASTER GDEM, we recommend to co-register all elevation data to ICESat as a global vertical reference system. The proposed methodological framework is exemplified for elevation changes on the Fox, Franz Joseph, Tasman and Murchison glaciers of New Zealand and the glaciers of central Spitsbergen, Svalbard.

  8. Changes in the soil moisture regime in the aeration zone after setting the Gabcikovo hydroelectric power structures into operation

    International Nuclear Information System (INIS)

    Setting the hydroelectric power structures Gabcikovo into operation impacts the regime of surface and ground water. Changes in the ground water regime are transferred to the biosphere through the aeration zone. These changes are manifested in the changes of soil moisture regime in the aeration zone. It may be stated that if there is an increase of the ground water level due to construction of hydroelectric power structures, then there is also an increase in humidity in the aeration zone, while it may occasionally remain unchanged at some locations, in no case does it decrease. The same is valid also reciprocally. If there is a drop of ground water level due to hydroelectric power structures, then there is also a decrease of moisture in the aeration zone, occasionally it may be unchanged at some locations, but in no case does it increase. Therefore, neither increase of moisture due to the decrease of ground water level, nor the opposite can happen. Changes in the soil moisture in the aeration zone for selected localities along the Danube are charted on the graphs for the interval of years 1990-1994. For the comparison the fluctuation of the ground water, the date of damming the Danube and the date of the start of river branches water supply, etc., are given. (authors). 1 tabs., 17 figs., 10 maps, 10 refs

  9. Evolution in a transmissible cancer: a study of the chromosomal changes in devil facial tumor (DFT) as it spreads through the wild Tasmanian devil population.

    Science.gov (United States)

    Pearse, Anne-Maree; Swift, Kate; Hodson, Pamela; Hua, Bobby; McCallum, Hamish; Pyecroft, Stephen; Taylor, Robyn; Eldridge, Mark D B; Belov, Katherine

    2012-03-01

    Tasmanian devils (Sarcophilus harrisii) are the largest extant marsupial carnivores. This species, now confined to Tasmania, is endangered from the emergence of a transmissible cancer, devil facial tumor disease (DFTD). In the present study, we use cytogenetic and molecular techniques to examine the stability of devil facial tumor (DFT) cell lines across time and space. This article describes disease progression from February 2004 to June 2011. We demonstrate evolutionary changes in the disease, which affects devils in different sites across Tasmania and over a period of several years, producing several chromosomal variants (strains) that are capable of transmission between devils. We describe the evolution of DFTs in the field and speculate on the possible impacts on the disease, including (1) development of less aggressive forms of the disease; (2) development of more aggressive forms of the disease; (3) development of forms capable of affecting closely related species of dasyurids (e.g., quolls); (4) extinction of the disease as it acquires additional deleterious mutations that affect either cell viability or transmissibility; and (5) co-evolution of the disease and the host. We also speculate about the future of the Tasmanian devil in the wild. We note that although DFTs are regarded as unstable by comparison with another much older transmissible cancer, canine transmissible venereal tumor (CTVT), the potential for development of less aggressive forms of DFTs or for development of resistance in devils is limited by devils' small numbers, low genetic diversity, and restricted geographical distribution. PMID:22469509

  10. Barriers to access prevention of mother-to-child transmission for HIV positive women in a well-resourced setting in Vietnam

    Directory of Open Access Journals (Sweden)

    Wright Pamela

    2008-04-01

    Full Text Available Abstract Background According to Vietnamese policy, HIV-infected women should have access at least to HIV testing and Nevirapine prophylaxis, or where available, to adequate counselling, HIV infection staging, ARV prophylaxis, and infant formula. Many studies in high HIV prevalence settings have reported low coverage of PMTCT services, but there have been few reports from low HIV prevalence settings, such as Asian countries. We investigated the access of HIV-infected pregnant women to PMTCT services in the well-resourced setting of the capital city, Hanoi. Methods Fifty-two HIV positive women enrolled in a self-help group in Hanoi were consulted, through in-depth interviews and bi-weekly meetings, about their experiences in accessing PMTCT services. Results Only 44% and 20% of the women had received minimal and comprehensive PMTCT services, respectively. Nine women did not receive any services. Twenty-two women received no counselling. The women reported being limited by lack of knowledge and information due to poor counselling, gaps in PMTCT services, and fear of stigma and discrimination. HIV testing was done too late for optimal interventions and poor quality of care by health staff was frequently mentioned. Conclusion In a setting where PMTCT is available, HIV-infected women and children did not receive adequate care because of barriers to accessing those services. The results suggest key improvements would be improving quality of counselling and making PMTCT guidelines available to health services. Women should receive early HIV testing with adequate counselling, safe care and prophylaxis in a positive atmosphere towards HIV-infected women.

  11. The cost of changing physical activity behaviour: evidence from a "physical activity pathway" in the primary care setting

    Directory of Open Access Journals (Sweden)

    Bull Fiona C

    2011-05-01

    Full Text Available Abstract Background The 'Physical Activity Care Pathway' (a Pilot for the 'Let's Get Moving' policy is a systematic approach to integrating physical activity promotion into the primary care setting. It combines several methods reported to support behavioural change, including brief interventions, motivational interviewing, goal setting, providing written resources, and follow-up support. This paper compares costs falling on the UK National Health Service (NHS of implementing the care pathway using two different recruitment strategies and provides initial insights into the cost of changing physical activity behaviour. Methods A combination of a time driven variant of activity based costing, audit data through EMIS and a survey of practice managers provided patient-level cost data for 411 screened individuals. Self reported physical activity data of 70 people completing the care pathway at three month was compared with baseline using a regression based 'difference in differences' approach. Deterministic and probabilistic sensitivity analyses in combination with hypothesis testing were used to judge how robust findings are to key assumptions and to assess the uncertainty around estimates of the cost of changing physical activity behaviour. Results It cost £53 (SD 7.8 per patient completing the PACP in opportunistic centres and £191 (SD 39 at disease register sites. The completer rate was higher in disease register centres (27.3% vs. 16.2% and the difference in differences in time spent on physical activity was 81.32 (SE 17.16 minutes/week in patients completing the PACP; so that the incremental cost of converting one sedentary adult to an 'active state' of 150 minutes of moderate intensity physical activity per week amounts to £ 886.50 in disease register practices, compared to opportunistic screening. Conclusions Disease register screening is more costly than opportunistic patient recruitment. However, additional costs come with a higher

  12. Utility of antenatal HIV surveillance data to evaluate prevention of mother-to-child HIV transmission programs in resource-limited settings.

    Science.gov (United States)

    Bolu, Omotayo; Anand, Abhijeet; Swartzendruber, Andrea; Hladik, Wolfgang; Marum, Lawrence H; Sheikh, Abdullahi Ahmed; Woldu, Aseged; Ismail, Shabbir; Mahomva, Agnes; Greby, Stacie; Sabin, Keith

    2007-09-01

    Prevention of mother-to-child human immunodeficiency virus (HIV) transmission (PMTCT) programs are expanding in resource-limited countries and are increasingly implemented in antenatal clinics (ANC) in which HIV sentinel surveillance is conducted. ANC sentinel surveillance data can be used to evaluate the first visit of a pregnant woman to PMTCT programs. We analyzed data from Kenya and Ethiopia, where information on PMTCT test acceptance was collected on the 2005 ANC sentinel surveillance forms. For Zimbabwe, we compared the 2005 ANC sentinel surveillance data to the PMTCT program data. ANC surveillance data allowed us to calculate the number of HIV-positive women not participating in the PMTCT program. The percentage of HIV-positive women missed by the PMTCT program was 17% in Kenya, 57% Ethiopia, and 59% Zimbabwe. The HIV prevalence among women participating in PMTCT differed from women who did not. ANC sentinel surveillance can be used to evaluate and improve the first encounter in PMTCT programs. Countries should collect PMTCT-related program data through ANC surveillance to strengthen the PMTCT program. PMID:17825646

  13. Impact of anthropogenic and natural environmental changes on Echinococcus transmission in Ningxia Hui Autonomous Region, the People’s Republic of China

    Directory of Open Access Journals (Sweden)

    Yang Yu

    2012-07-01

    Full Text Available Abstract Echinococcus transmission is known to be affected by various environmental factors, which may be modified by human influence or natural events including global warming. Considerable population growth in the last fifty years in Ningxia Hui Autonomous Region (NHAR, the People’s Republic of China (PRC, has led to dramatic increases in deforestation and modified agricultural practices. In turn, this has resulted in many changes in the habitats for the definitive and intermediate hosts of both Echinococcus granulosus and E. multilocularis, which have increased the risks for transmission of both parasites, affecting echinococcosis prevalence and human disease. Ecological environmental changes due to anthropogenic activities and natural events drive Echinococcus transmission and NHAR provides a notable example illustrating how human activity can impact on a parasitic infection of major public health significance. It is very important to continually monitor these environmental (including climatic factors that drive the distribution of Echinococcus spp. and their impact on transmission to humans because such information is necessary to formulate reliable future public health policy for echinococcosis control programs and to prevent disease spread.

  14. Age-targeted HIV treatment and primary prevention as a ‘ring fence’ to efficiently interrupt the age patterns of transmission in generalized epidemic settings in South Africa

    Science.gov (United States)

    Bershteyn, Anna; Klein, Daniel J.; Eckhoff, Philip A.

    2016-01-01

    Background Generalized HIV epidemics propagate to future generations according to the age patterns of transmission. We hypothesized that future generations could be protected from infection using age-targeted prevention, analogous to the ring-fencing strategies used to control the spread of smallpox. Methods We modeled age-targeted or cohort-targeted outreach with HIV treatment and/or prevention using EMOD-HIV v0·8, an individual-based network model of HIV transmission in South Africa. Results Targeting ages 20 to 30 with intensified outreach, linkage, and eligibility for antiretroviral therapy (ART) averted 45% as many infections as universal outreach for approximately one-fifth the cost beyond existing HIV services. Though cost-effective, targeting failed to eliminate all infections to those under 20 due to vertical and inter-generational transmission. Cost-effectiveness of optimal prevention strategies included US$6238 per infection averted targeting ages 10–30, US$5031 targeting 20–30, US$4279 targeting 22–27, and US$3967 targeting 25–27, compared to US$10 812 for full-population test-and-treat. Minimizing burden (disability-adjusted life years [DALYs]) rather than infections resulted in older target age ranges because older adults were more likely to receive a direct health benefit from treatment. Conclusions Age-targeted treatment for HIV prevention is unlikely to eliminate HIV epidemics, but is an efficient strategy for reducing new infections in generalized epidemics settings. PMID:27008897

  15. Preventing transmission of infectious agents in the pediatric in-patients hematology–oncology setting: what is the role for non-pharmacological prophylaxis?

    Directory of Open Access Journals (Sweden)

    Désirée Caselli

    2011-03-01

    Full Text Available Despite a continuous will to protect the immune compromised host from infections, evidence based indications for intervention by non-pharmacological toools are still lacking in oncology. Nevertheless, guidelines on standard precaution and trasmission base precaution are available. They may be important in order to reduce the risk of trasmission of infection in selected healthcare settings, such as the pediatric hematology-oncology wards. . AIEOP Centers agree that for children treated with chemotherapy both of these approaches should be implemented and vigorously enforced, while additional policies, including strict environmental isolation should be restricetd to patients with selected clinical conditions or complications.

  16. Kansas Electric Transmission Lines

    Data.gov (United States)

    Kansas Data Access and Support Center — This data set is a digital representation of the EletcircTransmission lines for the State of Kansas as maintained by the Kansas Corporation Commission. Data is...

  17. Glia and extracellular matrix changes affect extracellular diffusion and volume transmission in the brain in health and disease

    Czech Academy of Sciences Publication Activity Database

    Vargová, Lýdia; Syková, Eva

    2011-01-01

    Roč. 59, S1 (2011), S38. ISSN 0894-1491. [European meeting on Glial Cells in Health and Disease /10./. 13.09.2011-17.09.2011, Prague] Institutional research plan: CEZ:AV0Z50390512; CEZ:AV0Z50390703 Keywords : diffusion * extracellular matrix * extrasynaptic transmission Subject RIV: FH - Neurology

  18. Combination therapy using intratumoral bacillus Calmette-Guerin (BCG) and vincristine in dogs with transmissible venereal tumours : therapeutic efficacy and histological changes : article

    OpenAIRE

    S. Mukaratirwa; S. Chitanga; T. Chimatira; C. Makuleke; S.T. Sayi; E. Bhebhe

    2009-01-01

    Therapeutic efficacy and histological changes after bacillus Calmette-Guerin (BCG), vincristine and BCG/vincristine combination therapy of canine transmissible venereal tumours (CTVT) were studied. Twenty dogs with naturally occurring CTVT in the progression stage were divided into 4 groups and treated with intratumoral BCG, vincristine, BCG/vincristine combination therapy or intratumoral buffered saline (control group). Tumour sizes were determined weekly and tumour response to therapy was a...

  19. Setting objectives for community and systems change: an application of concept mapping for planning a statewide health improvement initiative.

    Science.gov (United States)

    Trochim, William M K; Milstein, Bobby; Wood, Betty J; Jackson, Susan; Pressler, Virginia

    2004-01-01

    The Hawaii Department of Health (HDOH) used concept mapping techniques to engage local stakeholders and national subject area experts in defining the community and system factors that affect individuals' behaviors related to tobacco, nutrition, and physical activity. Over eight working days, project participants brainstormed 496 statements (edited to a final set of 90), which were then sorted and rated for their importance and feasibility. A sequence of multivariate statistical analyses, including multidimensional scaling and hierarchical cluster analysis, generated maps and figures that were then interpreted by project stakeholders. The results were immediately incorporated into an official plan, approved by the governor and state legislature, recommending how Hawaii's tobacco settlement resources could be used to create sustainable changes in population health. The results also provide empirical support for the premise that both community and systems factors ought to be considered when planning comprehensive health improvement initiatives. PMID:14965431

  20. Studies on Clinical Aspects, Pathological Changes, Immunohistochemistry, 14-3-3 protein, PrP Gene, and Animal Transmission of Creutzldt-Jakob Disease in China

    Institute of Scientific and Technical Information of China (English)

    Lin Shilie; Zhao Jiexu; Jiang Xinmei; Song Xiaonan; Wang Weimin; Fan Yengyeng; Tao Yuiqin; Chen Xiuyun

    2000-01-01

    Objectives To investigate the clinical manifestations, pathological changes, expression of PrP gene, 14-3-3 protein in cerebrospinal fluid (CSF) and experimental animal transmission of Creuizfeldt-Jakob disease (CJD) in China. Methods Clinical aspects of 24 patients with CJD which was confirmed neuropathological were evaluated. Brain sections of 10 cases of them were given immunostaining with antiserum to a synthetic polypeptide of prioni protein (PrP). PrP gene was analyzed in 10 cases, and 14-3-3 protein in CSF was detected in 5 cases. Experimental mouse transmission was carried out using brain suspension from 7 patients with CJD. Results 1) Nineteen cases with sporadic CJD, 3 cases with iatrogenic CJD, 1 case with inherited CJD and 1 case with coexistence of Alzheimer disease(AD) and CJD were found. 2) The percentage of acute and subacute onset was high up to 96%. The illness duration was shorter in a subacute onset and the brain atrophy was not obvious.3) The synaptic type of PrP deposition was shown in paraffin sections in all -cases by immunostaining.4) 14-3-3 protein was detected in 5 eases in cerebrospinal fluid with CJD 5) Spongiform degeneration and PrP deposition could be shown in the brain sections of experimental mouse transmission. Conclusion There are special characteristics in clinical aspects of CJD in China. The detection of 14-3-3 protein can provide objective evidence for early diagnosis of CJD in order to prevent its transmission

  1. Impaired fear recognition and attentional set-shifting is associated with brain structural changes in alcoholic patients.

    Science.gov (United States)

    Trick, Leanne; Kempton, Matthew J; Williams, Steven C R; Duka, Theodora

    2014-11-01

    Alcoholic patients with multiple detoxifications/relapses show cognitive and emotional deficits. We performed structural magnetic resonance imaging and examined performance on a cognitive flexibility task (intra-extradimensional set shift and reversal; IED). We also presented subjects with fearful, disgust and anger facial emotional expressions. Participants were abstaining, multiply detoxified (MDTx; n = 12) or singly detoxified patients (SDTx; n = 17) and social drinker controls (n = 31). Alcoholic patients were less able than controls to change their behavior in accordance with the changing of the rules in the IED and they were less accurate in recognizing fearful expressions in particular. They also showed lower gray matter volume compared with controls in frontal brain areas, including inferior frontal cortex (IFC) and insula that mediate emotional processing, inferior parietal lobule and medial frontal cortex that mediate attentional and motor planning processes, respectively. Impairments in performance and some of the regional decreases in gray matter were greater in MDTx. Gray matter volume in IFC in patients was negatively correlated with the number of detoxifications, whereas inferior parietal lobule was negatively correlated with the control over drinking score (impaired control over drinking questionnaire). Performance in IED was also negatively correlated with gray matter volume in IFC/BA47, whereas recognition of fearful faces was positively correlated with the IFC gray matter. Repeated episodes of detoxification from alcohol, related to severity of dependency, are coupled with altered brain structure in areas of emotional regulation, attention and motor planning. Such changes may confer increased inability to switch behavior according to environmental demands and social incompetence, contributing to relapse. PMID:25123156

  2. No effect of insecticide treated curtain deployment on aedes infestation in a cluster randomized trial in a setting of low dengue transmission in Guantanamo, Cuba.

    Directory of Open Access Journals (Sweden)

    Maria Eugenia Toledo

    Full Text Available The current study evaluated the effectiveness and cost-effectiveness of Insecticide Treated Curtain (ITC deployment for reducing dengue vector infestation levels in the Cuban context with intensive routine control activities. A cluster randomized controlled trial took place in Guantanamo city, east Cuba. Twelve neighborhoods (about 500 households each were selected among the ones with the highest Aedes infestation levels in the previous two years, and were randomly allocated to the intervention and control arms. Long lasting ITC (PermaNet were distributed in the intervention clusters in March 2009. Routine control activities were continued in the whole study area. In both study arms, we monitored monthly pre- and post-intervention House Index (HI, number of houses with at least 1 container with Aedes immature stages/100 houses inspected, during 12 and 18 months respectively. We evaluated the effect of ITC deployment on HI by fitting a generalized linear regression model with a negative binomial link function to these data.At distribution, the ITC coverage (% of households using ≥1 ITC reached 98.4%, with a median of 3 ITC distributed/household. After 18 months, the coverage remained 97.4%. The local Aedes species was susceptible to deltamethrin (mosquito mortality rate of 99.7% and the residual deltamethrin activity in the ITC was within acceptable levels (mosquito mortality rate of 73.1% after one year of curtain use. Over the 18 month observation period after ITC distribution, the adjusted HI rate ratio, intervention versus control clusters, was 1.15 (95% CI 0.57 to 2.34. The annualized cost per household of ITC implementation was 3.8 USD, against 16.8 USD for all routine ACP activities.Deployment of ITC in a setting with already intensive routine Aedes control actions does not lead to reductions in Aedes infestation levels.

  3. Foraging choices of vampire bats in diverse landscapes: potential implications for land use change and disease transmission

    OpenAIRE

    Streicker, Daniel G.; Jacob E. Allgeier

    2016-01-01

    In Latin America, the common vampire bat Desmodus rotundus is the primary reservoir of rabies, a zoonotic virus that kills thousands of livestock annually and causes sporadic and lethal human rabies outbreaks. The proliferation of livestock provides an abundant food resource for this obligate blood-feeding species that could alter its foraging behaviour and rabies transmission, but poor understanding of the dietary plasticity of vampire bats limits understanding of how livestock influences ra...

  4. The monetary transmission mechanism

    OpenAIRE

    Ireland, Peter N.

    2006-01-01

    The monetary transmission mechanism describes how policy-induced changes in the nominal money stock or the short-term nominal interest rate impact on real variables such as aggregate output and employment. Specific channels of monetary transmission operate through the effects that monetary policy has on interest rates, exchange rates, equity and real estate prices, bank lending, and firm balance sheets. Recent research on the transmission mechanism seeks to understand how these channels work ...

  5. Effects of a healthy food supply intervention in a military setting: positive changes in cereal, fat and sugar containing foods

    Directory of Open Access Journals (Sweden)

    Bingham Clarissa ML

    2012-07-01

    Full Text Available Abstract Background In Finland, all men are liable to military service and a clear majority completes service. The increasing prevalence of obesity also among soldiers concerns conscripts’ food choices. Conscripts are served nutritionally planned regular main meals but individual choices take place in free-time eating. This study assesses the effects in conscripts’ eating habits in an intervention targeting the supply of healthy foods available in the military setting. Methods Participants were 604 18-21-year old male conscripts of whom 242 belonged to Control Group and 362 to Intervention Group. Participants of Control Group were historical controls performing military service one year before Intervention Group. The intervention targeted selection, placement, and attractiveness of healthy foods in garrison refectories and soldier’s home cafeterias, the two main food providers in the military. Dietary intake data was collected by self-administered questionnaire at three time points: before/beginning of military service (T0, 8 weeks (T1 and 6 months (T2 of military service. Outcome measures were food consumption frequencies and four dietary indexes (Cereal Index, Fruit and Vegetable Index, Fat Index and Sugar Index developed to characterize the diet. Changes between study groups in outcome variables and in time were analysed by repeated-measures analysis of covariance. Results Significant (p  Conclusions In the military setting, healthier food choices can be promoted by intervening on the main food environments by improving the supply of healthy foods. However, impacting on conscripts’ individual selection as fruit and vegetable consumption is more challenging.

  6. Application of Ecosystem Models to Assess Environmental Drivers of Mosquito Abundance and Virus Transmission Risk and Associated Public Health Implications of Climate and Land Use Change

    Science.gov (United States)

    Melton, F.; Barker, C.; Park, B.; Reisen, W.; Michaelis, A.; Wang, W.; Hashimoto, H.; Milesi, C.; Hiatt, S.; Nemani, R.

    2008-12-01

    The NASA Terrestrial Observation and Prediction System (TOPS) is a modeling framework that integrates satellite observations, meteorological observations, and ancillary data to support monitoring and modeling of ecosystem and land surface conditions in near real-time. TOPS provides spatially continuous gridded estimates of a suite of measurements describing environmental conditions, and these data products are currently being applied to support the development of new models capable of forecasting estimated mosquito abundance and transmission risk for mosquito-borne diseases such as West Nile virus. We present results from the modeling analyses, describe their incorporation into the California Vectorborne Disease Surveillance System, and describe possible implications of projected climate and land use change for patterns in mosquito abundance and transmission risk for West Nile virus in California.

  7. Changes in Default Alarm Settings and Standard In-Service are Insufficient to Improve Alarm Fatigue in an Intensive Care Unit: A Pilot Project

    OpenAIRE

    Sowan, Azizeh Khaled; Gomez, Tiffany Michelle; Tarriela, Albert Fajardo; Reed, Charles Calhoun; Paper, Bruce Michael

    2016-01-01

    Background Clinical alarm systems safety is a national concern, specifically in intensive care units (ICUs) where alarm rates are known to be the highest. Interventional projects that examined the effect of changing default alarm settings on overall alarm rate and on clinicians’ attitudes and practices toward clinical alarms and alarm fatigue are scarce. Objective To examine if (1) a change in default alarm settings of the cardiac monitors and (2) in-service nursing education on cardiac monit...

  8. Poverty and price transmission

    DEFF Research Database (Denmark)

    Elleby, Christian

    A key parameter determining the welfare impact from a world market shock is the transmission elasticity which measures the average domestic response to an international price change. Many studies have estimated price transmission elasticities for a large number of countries but the variation in t...

  9. Taphonomy of deciduous leaves and changes in the d13C signal after deposition in fresh water settings

    Science.gov (United States)

    Reimann, Simon; Roth-Nebelsick, Anita; Nebelsick, James; Grein, Michaela

    2016-04-01

    Carbon isotopic signals from fossil plant material are an important source of information for palaeoecology and palaeoclimatology. Usually, the 13C isotope is depleted in plant material, compared to the atmospheric 13C content, because 13C is discriminated against 12C during the process of photosynthesis. The degree of 13C discrimination depends on the photosynthetic pathway (C3, C4 and CAM) and is substantially affected by environmental factors (for example, water stress). Various plant material components, however, differ also with respect to their 13C content. It is generally assumed that the d13C signal found in fossil plants reflects that of the living plant to a sufficient degree. Obtaining information on possible alterations during the taphonomic process is, however, desirable. In this study, changes in d13C of deciduous leaves are monitored, from the living leaf still attached to the tree to leaves deposited in fresh water setting for one or more years, thus focusing on early stages of taphonomy. The considered taxa are species from Quercus (oak) and Fagus (beech). Deposited leaves from three fresh water environments in Southwestern Germany were studied: active stream in a forest, still water pond in a forest, and a waterlogged moor environment. Additionally to the isotope measurements, the degree of leaf tissue degradation and colonization with degrading organisms were observed with Scanning Electron Microscopy.

  10. From 2020 to 2030, from Copenhagen to Paris: a mind-set change for the European climate policy?

    International Nuclear Information System (INIS)

    The European Councils of March 2007 and October 2014 have defined the major guidelines of the European climate policy for the 2010-2020 and 2020-2030 decades. These commitments have then been used as negotiation road-maps for two major conferences on climate held under the United-Nations umbrella, in Copenhagen in 2009 and in Paris in December 2015. In both cases, the aim was, and still is, to reach a global agreement to take over the Kyoto Protocol. The first one was a failure for the European diplomacy and all hopes are now placed in the second, which may well be the last chance for the international climate talks. After seven years, time frames look similar but the context is very different. Domestically, the economic crisis has constrained the investment capacity of Member States and pushed competitiveness higher in the ranks of priorities. Internationally, the centre of gravity of energy demand and greenhouse gases emissions has shifted to emerging countries, advocating for an update of the North-South paradigm which had governed the Kyoto protocol. Lastly, although there is no coordinated action against global warming at this stage, the urgent need to act receives a wider support and more and more initiatives are taken, such as the ones recently announced by China and the United-States. Because of these elements, among others, the EU cannot simply extend the approach initiated seven years ago. The European climate policy opens a new chapter and the conclusions of the European Council of October 2014 have clearly set the tone. A change of mind-set may have occurred, in the sense that the 2030 targets reaffirm Europe's commitment to the shift towards a low carbon economy, while instigating more flexibility to ensure stronger cost-effectiveness. It is a strong signal for the world but this renewed approach still needs to be consolidated, both in the way of implementing the key reforms announced and in the way of approaching the Paris conference

  11. Assessing the potential impact and uncertainty of climate, land use change and demographic trends on malaria transmission in Africa by 2050.

    Science.gov (United States)

    Tompkins, Adrian; Caporaso, Luca; Colon-Gonzalez, Felipe

    2014-05-01

    Previous analyses of data has shown that in addition to variability and longer term trends in climate variables, both land use change (LUC) and population mobility and urbanisation trends can impact malaria transmission intensities and socio-economic burden. With the new regional VECTRI dynamical malaria model it is now possible to examine these in an integrated modelling framework. Using 5 global climate models which were bias corrected using the WATCH data for the recent ISIMIP project, the four Representative Concentration Pathways (RCP), population projections disaggregated from the Shared Socioeconomic Pathways (SSP) and Land use change from the HYDE model output used in the CMIP5 process, we construct a multi-member ensemble of malaria transmission intensity projections for 2050. The ensemble integrations indicate that climate has the leading impact on malaria changes, but that population growth and urbanisation can offset the effect of climate locally. LUC impacts can also be significant on the local scale but their assessment is highly uncertain and only indicative in this study. It is argued that the study should be repeated with a range of malaria models or VECTRI configurations in order to assess the additional uncertainty due to the malaria model assumptions.

  12. In situ transmission electron microscopy study on microstructural changes in NbF5-doped MgH2 during dehydrogenation

    International Nuclear Information System (INIS)

    Microstructural changes in NbF5-doped MgH2 during the dehydrogenation reaction (MgH2 → Mg + H2) have been investigated by in situ heating transmission electron microscopy. Nanocrystalline MgH2 shows fast hydrogen sorption kinetics, as well as a high density of defects induced by high-energy ball milling. Since the network-structured Nb layer covering Mg grains acts both as an impediment to grain growth of Mg and a gateway for hydrogen diffusion by forming metastable NbH1-x, the improved kinetics can be maintained during hydrogen cycling.

  13. Game Changing Usage of High-Voltage Power Transmission Systems as Extremely Large Antennas for Space Physical and Geophysical Remote Imaging Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Geomagnetic storms drive geomagnetically induced currents (GIC) in high-voltage power transmission systems worldwide. GIC distribution in the transmission system is...

  14. 基于集对分析法的输变电项目经济效益后评估%Post-evaluation of Economic Benefit of Power Transmission Project Based on Set Pair Analysis

    Institute of Scientific and Technical Information of China (English)

    周冰; 蒋政; 傅进; 杨毅

    2013-01-01

    This article firstly introduces set pair analysis into the post-evaluation of economic benefit of power transmission, and puts forward detailed calculated ways and steps of applying set pair analysis into post-evaluation of economic benefit for single project. Meanwhile it uses judgment matrix of hierarchy analysis to determine various index weights. Taking the construction project of a 35KV substation for example, after the post-evaluation of economic benefit the results turn out that this way can make scientific and reasonable evaluation. It enjoys the merits of brief calculation, convenient operation and high credibility.%首次把集对分析法引入到输变电项目经济效益后评价中,提出了应用集对分析法对单一项目进行经济效益后评价的具体计算方法和步骤,并利用层次分析法的判断矩阵确定各指标权重.以某35 kV变电站的建设项目为算例,进行了经济效益后评价,结果显示该方法可以做出比较科学合理的评价,计算简明,便于操作,且可信度高.

  15. Hamstring Fatigue and Muscle Activation Changes During Six Sets of Nordic Hamstring Exercise in Amateur Soccer Players.

    Science.gov (United States)

    Marshall, Paul W M; Lovell, Ric; Knox, Michael F; Brennan, Scott L; Siegler, Jason C

    2015-11-01

    The Nordic hamstring exercise (NHE) is a bodyweight movement commonly prescribed to increase eccentric hamstring strength and reduce the incidence of strain injury in sport. This study examined hamstring fatigue and muscle activation responses throughout 6 sets of 5 repetitions of the NHE. Ten amateur-level soccer players performed a single session of 6 sets of 5 repetitions of NHE. Maximal eccentric and concentric torque output (in newton meters) was measured after every set. Hamstrings electromyograms (EMG) were measured during all maximal contractions and exercise repetitions. Hamstring maximal eccentric torque was reduced throughout the range of motion after only a single set of NHE between 7.9 and 17.1% (p ≤ 0.05), with further reductions in subsequent sets. Similarly, maximal concentric torque reductions between 7.8 and 17.2% were observed throughout the range of motion after 1 set of NHE (p ≤ 0.05). During the descent phase of the NHE repetitions, hamstring muscle activity progressively increased as the number of sets performed increased. These increases were observed in the first half of the range of motion. During the ascent phase, biceps femoris muscle activity but not medial hamstrings was reduced from the start of exercise during latter sets of repetitions. These data provide unique insight into the extent of fatigue induced from a bodyweight only exercise after a single set of 5 repetitions. Strength and conditioning coaches need to be aware of the speed and extent of fatigue induced from NHE, particularly in practical settings in which this exercise is now prescribed before sport-specific training sessions (i.e., the FIFA-11 before soccer training). PMID:25886019

  16. How often should a red blood cell administration set be changed while a patient is being transfused? A commentary and review of the literature.

    Science.gov (United States)

    Blest, A; Roberts, M; Murdock, J; Watson, D; Brunskill, S

    2008-04-01

    Current recommendations vary with regard to the frequency of change of a red blood cell (RBC) administration set. A full review was undertaken to evaluate the recommendations for how often a RBC administration set should be changed while a patient is being transfused. Comprehensive searches of Medline, Embase, Cinahl, the Cochrane Library, handsearching of transfusion journals, guidelines and websites and contact with administration set manufacturers identified 32 relevant papers: 11 clinical updates; 11 guidelines; 5 manufacturer data sheets; 3 standards; 1 Department of Health report and 1 expert opinion. Recommendations varied widely across papers. There was no pattern in recommendation by paper type, date or country of origin. Recommendations were based on change of RBC administration set either after a given number of hours or number of RBC units. The recommendations varied widely and ranged from 4 to 48 h and from 'every unit' to 'several units'. The most frequent recommendations were change of RBC administration set after 12 h or 4 units. Methodological quality of the included papers is poor. There is no formal evidence base on which to support current recommendations or challenge the current British Committee for Standards in Haematology guideline. Targeted research aimed at establishing an evidence base may be warranted and would need to document other variables that can impact frequency of change, including type of filter, age of blood and duration of RBC transfusion. PMID:18399846

  17. The effectiveness of multi-component goal setting interventions for changing physical activity behaviour: a systematic review and meta-analysis.

    Science.gov (United States)

    McEwan, Desmond; Harden, Samantha M; Zumbo, Bruno D; Sylvester, Benjamin D; Kaulius, Megan; Ruissen, Geralyn R; Dowd, A Justine; Beauchamp, Mark R

    2016-03-01

    Drawing from goal setting theory (Latham & Locke, 1991; Locke & Latham, 2002; Locke et al., 1981), the purpose of this study was to conduct a systematic review and meta-analysis of multi-component goal setting interventions for changing physical activity (PA) behaviour. A literature search returned 41,038 potential articles. Included studies consisted of controlled experimental trials wherein participants in the intervention conditions set PA goals and their PA behaviour was compared to participants in a control group who did not set goals. A meta-analysis was ultimately carried out across 45 articles (comprising 52 interventions, 126 effect sizes, n = 5912) that met eligibility criteria using a random-effects model. Overall, a medium, positive effect (Cohen's d(SE) = .552(.06), 95% CI = .43-.67, Z = 9.03, p goal setting interventions in relation to PA behaviour was found. Moderator analyses across 20 variables revealed several noteworthy results with regard to features of the study, sample characteristics, PA goal content, and additional goal-related behaviour change techniques. In conclusion, multi-component goal setting interventions represent an effective method of fostering PA across a diverse range of populations and settings. Implications for effective goal setting interventions are discussed. PMID:26445201

  18. [Functional changes in the chromatophilic substance and RNA content of the cytoplasm of sympathetic neurons in the presence of synaptic transmission disorders].

    Science.gov (United States)

    Gorelikov, P L

    1981-07-01

    At a disturbed synaptic transmission in the rabbit cranial sympathetic cervical ganglion in histological sections stained with gallocyanin chrome alum, distribution of the chromatophilic substance was studied, and in the same sections RNA content was determined cytophotometrically. In ganglia of intact animals three groups of neurons with various structure of the chromatophilic substance were defined and their quantitative relation was stated. After administration of various doses of the ganglio-blockader, there was an essential difference in the changes of the chromatophilic substance, but they were unitypical in mono- and double-nuclear neurons. In the same cells, the synaptic blockade produced a rather great increase in the content of the cytoplasmic RNA. Comparing the quantitative data with the visual observation results, a conclusion was made that it is not reliable to use any changes in the chromatophilic substance as a criterium on quantitative shifts in the neuronal RNA and for the morphological test of the neuronal functional activity. PMID:6170279

  19. Change of teicoplanin loading dose requirement for incremental increases of systemic inflammatory response syndrome score in the setting of sepsis.

    Science.gov (United States)

    Nakano, Takafumi; Nakamura, Yoshihiko; Takata, Tohru; Irie, Keiichi; Sano, Kazunori; Imakyure, Osamu; Mishima, Kenichi; Futagami, Koujiro

    2016-08-01

    Background Target trough concentrations are recommended for teicoplanin (TEIC) to minimize its adverse effects and to maximize efficacy in sepsis caused by grampositive cocci, including methicillin-resistant Staphylococcus aureus infection. However, optimal doses to attain proper trough values in patients with sepsis have not yet been well established for TEIC. Objective This study investigated whether the systemic inflammatory response syndrome (SIRS) score could predict the pharmacokinetics of TEIC in patients with sepsis. Setting This study was conducted at Fukuoka University Hospital in Japan. Methods We retrospectively reviewed the records of patients using TEIC between April 2012 and March 2015. SIRS positive was defined as infection with a SIRS score ≥2. Estimates of pharmacokinetic parameters were calculated using a Bayesian method. Creatinine clearance rates were estimated by the Cockcroft-Gault formula (eCcr). Main outcome measure Change of TEIC loading dose requirement for incremental increases of SIRS score. Results In total, 133 patients were enrolled: 50 non-SIRS patients and 83 patients with SIRS. The TEIC plasma trough concentration was significantly lower in SIRS than non-SIRS patients (15.7 ± 7.1 vs. 20.1 ± 8.6 μg/mL; P < 0.01), although there was no significant difference in the loading dose administered. Moreover, SIRS scores were increasingly predictive of eCcr and TEIC clearance in a stepwise manner. To achieve the target trough concentration (15-30 μg/mL), the optimal doses required in non-SIRS versus SIRS patients were 12-24 versus 18-30 mg/kg/day, respectively, during the first 48 h. Conclusions These findings suggest that the pharmacokinetics of TEIC are altered in SIRS patients, who required higher doses than non-SIRS patients to achieve the target trough concentration. We suggest that the SIRS score can become a new modality to determine the initial TEIC loading dose. PMID:27125378

  20. Transmission issues

    International Nuclear Information System (INIS)

    This session on transmission issues focused on the role that transmission plays in electricity markets and the importance of getting the market structure right in terms of generation divestiture with buy back contracts, demand side responsive programs, transmission upgrades and long term contracts. The difficulties of distinguishing between market power and scarcity were examined along with some of the complications that ensue if transmission experiences congestion, as exemplified by the August 2003 blackout in eastern North America. The presentations described the best ways to handle transmission issues, and debated whether transmission should be deregulated or follow market forces. Issues of interconnections and reliability of connections were also debated along with the attempt to integrate renewables into the grid. Some presentations identified what new transmission must be built and what must be done to ensure that transmission gets built. The challenges and business opportunities for transmission in Alberta were discussed with reference to plans to invest in new infrastructure, where it is going outside of the province and how it works with other jurisdictions. Manitoba's Conawapa Hydro Project and its 2000 MW tie line to Ontario was also discussed. Some examples of non-optimal use of interconnections in Europe were also discussed in an effort to learn from these mistakes and avoid them in Canada. tabs., figs

  1. Combining process-based and correlative models improves predictions of climate change effects on Schistosoma mansoni transmission in eastern Africa.

    Science.gov (United States)

    Stensgaard, Anna-Sofie; Booth, Mark; Nikulin, Grigory; McCreesh, Nicky

    2016-01-01

    Currently, two broad types of approach for predicting the impact of climate change on vector-borne diseases can be distinguished: i) empirical-statistical (correlative) approaches that use statistical models of relationships between vector and/or pathogen presence and environmental factors; and ii) process-based (mechanistic) approaches that seek to simulate detailed biological or epidemiological processes that explicitly describe system behavior. Both have advantages and disadvantages, but it is generally acknowledged that both approaches have value in assessing the response of species in general to climate change. Here, we combine a previously developed dynamic, agentbased model of the temperature-sensitive stages of the Schistosoma mansoni and intermediate host snail lifecycles, with a statistical model of snail habitat suitability for eastern Africa. Baseline model output compared to empirical prevalence data suggest that the combined model performs better than a temperature-driven model alone, and highlights the importance of including snail habitat suitability when modeling schistosomiasis risk. There was general agreement among models in predicting changes in risk, with 24-36% of the eastern Africa region predicted to experience an increase in risk of up-to 20% as a result of increasing temperatures over the next 50 years. Vice versa the models predicted a general decrease in risk in 30-37% of the study area. The snail habitat suitability models also suggest that anthropogenically altered habitat play a vital role for the current distribution of the intermediate snail host, and hence we stress the importance of accounting for land use changes in models of future changes in schistosomiasis risk. PMID:27063739

  2. Rapid-cycle brainstorming: facilitating whole-systems change in time- and scheduling-challenged health care settings

    OpenAIRE

    Zakariasen, Kenneth

    2010-01-01

    Kenneth Zakariasen1, Isabel Henderson21Leadership and Organizational Change Studies Initiative, School of Public Health, University of Alberta, Edmonton, Alberta, Canada; 2Glenrose Rehabilitation Hospital, Alberta Health Services, Edmonton, Alberta, CanadaAbstract: Whole-systems approaches to organizational change dominate the contemporary change literature. They focus on widespread engagement of people within organizations, individual and collective ownership of both process and results, and...

  3. Continuously Variable Transmission

    Science.gov (United States)

    Grana, D. C.

    1985-01-01

    Chain slides along two cones, in novel transmission concept. Transmission includes chain drive between two splined shafts. Chain sprockets follow surfaces of two cones. As one chain sprocket moves toward smaller diameter other chain sprocket moves toward larger diameter, thereby changing "gear" ratio. Movement initiated by tension applied to chain by planetary gear mechanism. Device positive, simple, and efficient over wide range of speed ratios.

  4. Radiation stimulated changes in the transmission of chalcogenide glasses As2S3-Ge2S3

    International Nuclear Information System (INIS)

    The radiation - optical properties of chalcogenide glass-like semiconductors systems As2S3-Ge2S3 in the field of topological 2D-3D of phase transition are investigated. It is shown, that a gamma irradiation by an absorbed doze 4.4·106 Gy results in long-wave shift of a spectral position of their edge of optical passing. The observable effect depends on a structural type of researched glasses and essentially varies near to 2D-3D of phase transition. Two making shifts of an edge of passing are detected: static, remaining a constant long time after irradiation and dynamic, gradually damping during 2-3 months. It is supposed, that the microstructural mechanism of the data changes is stipulated by processes coordination defect creation in a structural framework of samples

  5. Morphological changes in the rat liver following lethal and fractionated telecobalt irradiation studied by transmission and scanning electron microscopy

    International Nuclear Information System (INIS)

    Fully grown male albino rats were treated with a single abdominal telecobalt irradiation of 2.000 r or with fractionated irradiation of the right side of the epigastrium with 15 x 500 r. A few days after, the animals were perfusion fixated. One day after irradiation with 2.000 r, the epithelial cells exhibit only slight changes. Three days after the treatment, the glycogen content of the cells is increased. The damage pattern of the endothelial cells of the sinus wall is particularly interesting. After fractionated irradiation of the liver with a total of 7.500 r, a different pattern is found which is similar to the pattern provoked by other noxae. After 120 days, group necroses can be found. (MG)

  6. A Secondary Voltage Control Method for an AC/DC Coupled Transmission System Based on Model Predictive Control

    DEFF Research Database (Denmark)

    Xu, Fengda; Guo, Qinglai; Sun, Hongbin;

    2015-01-01

    For an AC/DC coupled transmission system, the change of transmission power on the DC lines will significantly influence the AC systems’ voltage. This paper describes a method to coordinated control the reactive power of power plants and shunt capacitors at DC converter stations nearby, in order to...... keep the voltage of the pilot bus tracking its set point considering the DC system’s transmission schedule change. The approach is inspired by model predictive control (MPC) to compensate for predictable voltage change affected by DC side transmission power flow and the potential capacitor switching at...

  7. Simulation of SET Operation in Phase-Change Random Access Memories with Heater Addition and Ring-Type Contactor for Low-Power Consumption by Finite Element Modeling

    Institute of Scientific and Technical Information of China (English)

    GONG Yue-Feng; SONG Zhi-Tang; LING Yun; LIU Yan; FENG Song-Lin

    2009-01-01

    A three-dimensional finite element model for phase change random access memory (PCRAM) is established for comprehensive electrical and thermal analysis during SET operation. The SET behaviours of the heater addition structure (HS) and the ring-type contact in bottom electrode (RIB) structure are compared with each other. There are two ways to reduce the RESET current, applying a high resistivity interfaciai layer and building a new device structure. The simulation results indicate that the variation of SET current with different power reduction ways is little. This study takes the RESET and SET operation current into consideration, showing that the RIB structure PCRAM cell is suitable for future devices with high heat efficiency and high-density, due to its high heat efficiency in RESET operation.

  8. What's in an elevation difference? Accuracy and corrections of satellite elevation data sets for quantification of glacier changes

    OpenAIRE

    Nuth, C.; Kääb, A.

    2010-01-01

    There is an increasing number of DEMs available worldwide for deriving elevation differences over time, including vertical changes on glaciers. Most of these DEMs are heavily post-processed or merged, so that physical error modelling becomes impossible and statistical error modelling is required instead. We propose a three-step methodological framework for assessing and correcting DEMs to quantify glacier elevation changes: remove DEM shifts, check for elevation-dependent biases, and check fo...

  9. Poster: Observing change in crowded data sets in 3D space - Visualizing gene expression in human tissues

    KAUST Repository

    Rogowski, Marcin

    2013-03-01

    We have been confronted with a real-world problem of visualizing and observing change of gene expression between different human tissues. In this paper, we are presenting a universal representation space based on two-dimensional gel electrophoresis as opposed to force-directed layouts encountered most often in similar problems. We are discussing the methods we devised to make observing change more convenient in a 3D virtual reality environment. © 2013 IEEE.

  10. CHANGING TRENDS OF HIV INFECTION IN PPTCT (PREVENTION OF PARENT TO CHILD TRANSMISSION GOVERNMENT GENERAL HOSPITAL, GUNTUR, ANDHRA PRADESH, SOUTH INDIA, 2002-2013

    Directory of Open Access Journals (Sweden)

    Venkateswara Rao

    2014-09-01

    Full Text Available : INTRODUCTION: The objective of this study is to know the various changing trends in the HIV infection in the antenatal women attending the PPTCT department, Government General Hospital, Guntur, Andhra Pradesh, during 2002 to 2013. METHODS: This is a retrospective study done in Government General Hospital, Guntur, Andhra Pradesh, during 2002 to 2013. The data was collected from the records maintained in the PPTCT department and the changing trends of HIV infection in antenatal women were studied. RESULTS: The prevalence rate of HIV infection in antenatal women decreased from 4.4% to 0.84%. Monthly average number of HIV positive deliveries in our institution varies from 150 to 250 cases. Percentage of caesarian section done was about 20% of cases. More number of cases were from urban than rural areas. Initially the cases were more in low socio-economic status. Young primigravida women around 20 years were more infected. High risk behavior of the husband was mainly responsible for the transmission of the disease. HIV infection was common in the innocent housewife. CONCLUSION: The study concludes that the HIV infection among pregnant women in our institution shows various changing trends and a decreasing incidence due to the effective implementation of the PPTCT programme under the National AIDS control programme started in the year 2002.

  11. Reviews Book: SEP Communications: Transmitting and Receiving Signals Book: Gliding for Gold Book: Radioactivity: A History of a Mysterious Science Book: The New Quantum Age Books: The Art of Science and The Oxford Book of Modern Science Writing Equipment: SEP Analogue/digital transmission unit Equipment: SEP Optical signal transmission set Book: Stars and their Spectra Book: Voicebox: The Physics and Evolution of Speech Web Watch

    Science.gov (United States)

    2012-03-01

    WE RECOMMEND Transmitting and Receiving Signals SEP booklet transmits knowledge The New Quantum Age Understanding modern quantum theory The Art of Science and The Oxford Book of Modern Science Writing Anthologies bring science to life SEP Analogue/digital transmission unit Kit transmits signal between two points SEP Optical signal transmission set Optical kit shows light transmission Stars and their Spectra New book for teaching astrophysics WORTH A LOOK Gliding for Gold Take a journey through the physics of winter sports Radioactivity: A History of a Mysterious Science Book looks at history of radioactivity Voicebox: The Physics and Evolution of Speech TExploring the evolution of the voice WEB WATCH An interactive program with promise?

  12. Impaired fear recognition and attentional set-shifting is associated with brain structural changes in alcoholic patients

    OpenAIRE

    Trick, Leanne; Kempton, Matthew J.; Williams, Steven C.R.; Duka, Theodora

    2015-01-01

    Alcoholic patients with multiple detoxifications/relapses show cognitive and emotional deficits. We performed structural magnetic resonance imaging and examined performance on a cognitive flexibility task (intra-extradimensional set shift and reversal; IED). We also presented subjects with fearful, disgust and anger facial emotional expressions. Participants were abstaining, multiply detoxified (MDTx; n = 12) or singly detoxified patients (SDTx; n = 17) and social drinker controls (n = 31). A...

  13. Reliability and sensitivity to change of the OMERACT rheumatoid arthritis magnetic resonance imaging score in a multireader, longitudinal setting

    DEFF Research Database (Denmark)

    Haavardsholm, ea; Østergaard, Mikkel; Kvan, NP; Uhlig, TA; Lilleas, FG; Kvien, TK

    2005-01-01

    , erosion, and bone marrow edema status and for change scores. RESULTS: Intrareader ICCs were generally very high, both for status scores (median baseline and followup 0.89 and 0.90 for synovitis, 0.91 and 0.90 for erosion, and 0.90 and 0.98 for edema) and for change scores (median 0.80 for synovitis, 0...... scores (mean 0.74 for synovitis, 0.67 for erosion, and 0.95 for edema). The average-measure ICCs were > or =0.94 for all components of both the status scores and change scores. CONCLUSION: The RAMRIS showed very good intrareader reliability, good interreader reliability, and a high level of sensitivity...

  14. The change in the dynamics of Costa Rica’s electoral set up: a case of dealignment

    Directory of Open Access Journals (Sweden)

    Fernando SÁNCHEZ CAMPOS

    2010-10-01

    Full Text Available The results of the last two general elections (1998 and 2002 in Costa Rica, suggest that the country’s electoral dynamics have exited their apparent stability and entered a process of change. The present study evaluates the main signs of this change (rising levels of absenteeism, ticket-splitting, electoral volatility, and support for third parties, and defines it as an «electoral dealignment» process. Moreover, it argues that there is evidence to conclude that electoral dealignment in Costa Rica seems to be a result of a process of «partisan dealignment».

  15. Effect on transmission of HIV-1 resistance of timing of implementation of viral load monitoring to determine switches from first to second-line antiretroviral regimens in resource-limited settings

    DEFF Research Database (Denmark)

    Phillips, Andrew N; Pillay, Deenan; Garnett, Geoff; Bennett, Diane; Vitoria, Marco; Cambiano, Valentina; Lundgren, Jens

    2011-01-01

    There is concern that antiretroviral therapy (ART) use with only clinical monitoring for failure will result in high rates of transmission of virus with resistance to drugs currently in use.......There is concern that antiretroviral therapy (ART) use with only clinical monitoring for failure will result in high rates of transmission of virus with resistance to drugs currently in use....

  16. 2006 C. H. McCloy Research Lecture: Defining Learning as Conceptual Change in Physical Education and Physical Activity Settings

    Science.gov (United States)

    Ennis, Catherine D.

    2007-01-01

    The author discusses a line of research examining the acquisition, organization, and use of knowledge associated with conceptual change in which she is engaged at the University of Maryland. It builds on foundational research by scholars in science, mathematics, and reading education as well as in motor learning and physical education pedagogy,…

  17. Characterizing the regional pattern and temporal change of groundwater levels by analyses of a well log data set

    Institute of Scientific and Technical Information of China (English)

    Mahmuda PARVIN; Naoyuki TADAKUMA; Hisafumi ASAUE; Katsuaki KOIKE

    2011-01-01

    Preservation of the amount and quality of groundwater resources is an important issue around the world.Changes in groundwater levels need to be monitored in efforts to preserve groundwater.This study investigates suitable methods to characterize changes in the groundwater level and determine the factors involved.The area of Kumamoto,a city in central Kyushu,southwest Japan,was selected to demonstrate the usefulness of the methods because this area is one of the richest in Japan in terms of groundwater resources and takes all its water from groundwater.Data of the groundwater level recorded at 69 wells from 1979 to 2007 were used in geostatistical and correlogram analyses.First,strong correlation between the topography and groundwater level was identified.Incorporating this correlation into spatial modeling of the groundwater level,co-kriging was demonstrated to be more accurate than ordinary kriging.The co-kriging results clarified the hydraulic characteristics of the Kumamoto area; the patterns of shallow and deep groundwater levels were agreeable generally,and the general trends of their annual average levels were similar regardless of precipitation.Another important feature was that the correlograms for the precipitation amount and groundwater level had a constant shape and changed smoothly with a change in lag time regardless of the precipitation only in the area of Togawa lava.These characteristics are probably due to the connections between shallow and deep aquifers and the high permeability of Togawa lava.

  18. Mapping the changing landscape of fish-related journals: Setting a course for successful communication of scientific information

    Science.gov (United States)

    Mather, M. E.; Parrish, D.L.; Dettmers, J.M.

    2008-01-01

    In the last 25 years, the number and scope of fish-related journals have changed. New and existing journals are increasingly specialized. Journals that are read and cited are changing because of differential accessibility via electronic databases. In this review, we examine shifts in numbers and foci of existing fish-related journals. We ask how these fish-related metrics differ across type of application, ecological system, taxa, and discipline. Although many journals overlap to some extent in content, there are distinct groups of journals for authors to consider. By systematically reviewing the focus of an individual manuscript, comparing it to the suite of journals available and examining the audience for the manuscript, we believe that authors can make informed decisions about which journals are most suitable for their work. Our goal here is to help authors find relevant journals and deliver scientific publications to the appropriate readership.

  19. Improving hand hygiene compliance for the reduction of nosocomial infections: recommendations for behaviour change in a health care setting

    OpenAIRE

    Reason, Florence Paige

    2008-01-01

    Nosocomial infection rates are highly dependent on hand hygiene compliance within health care facilities. This paper examines the literature concerning elements of effective hand hygiene interventions and relevant behaviour change theory, in addition to current practice surrounding hand hygiene interventions in leading institutions, in order to inform and propose recommendations for the improvement and success of the University Health Network’s current hand hygiene initiative. The results of ...

  20. Nature of changes in body composition indices in students during physical training using a set of athleticism.

    OpenAIRE

    Chernozub A.A.

    2011-01-01

    During investigations it was established that there are important changes in body composition parameters university students, who in the classroom with the general physical culture introduced by the training facilities with athleticism. The level indicators of body composition and dynamics are fully dependent on the employment structure, volume and intensity of physical exertion their focus. It is established that achieving the optimal performance of body composition may occur even with minim...

  1. Assessment of regional climatic changes in the Eastern Himalayan region: a study using multi-satellite remote sensing data sets.

    Science.gov (United States)

    Agrawal, Anubha; Sharma, Anu Rani; Tayal, Shresth

    2014-10-01

    In this study, an attempt has been made to capture the sensitivity of a mountainous region to elevation-dependent warming and the response of a glacier-laden surface to increasing greenhouse gases (GHGs) and aerosol concentration. Some of the changes Sikkim has undergone due to urban sprawl are as follows: an increase of ~0.7 ± 0.46 °C temperature in the past 40 years at an altitude of 5.5 km; a 2.21 km(2)/year rate of loss of glacierised area in the past 33 years; an increase in absorbed longwave radiation (6 ± 2.41 W/m(2)); an increase in heat fluxes (2 ± 0.97 W/m(2)); a decrease in albedo during the last 30 years; an increase in the concentrations of carbon dioxide (4.42%), methane (0.61%), ozone (0.67%) and black carbon column optical depth (7.19%); a decrease in carbon monoxide (2.61%) and an increase in aerosol optical depth (19.16%) during the last decade; a decrease in precipitation, water yield, discharge and groundwater; and an increase in evapotranspiration during 1971-2005. Detection of three climate signals (1976, 1997 and 2005) in the entire analysis is the quantification of the fact that the climate of Sikkim is moving away from its inter-annual variability. An increase in temperature (0.23 °C/decade) at higher altitude (~5.5 km), suppression of precipitation, decreasing water availability and rapid loss of glacierised area are the evidences of the fact that air pollution is playing a significant role in bringing about regional climatic changes in Sikkim. In this study, change detection method has been used for the first time for the estimation of change in a glacierised area of the region. PMID:24947906

  2. Quantifying changes in the rates of forest clearing in Indonesia from 1990 to 2005 using remotely sensed data sets

    International Nuclear Information System (INIS)

    Timely and accurate data on forest change within Indonesia is required to provide government, private and civil society interests with the information needed to improve forest management. The forest clearing rate in Indonesia is among the highest reported by the United Nations Food and Agriculture Organization (FAO), behind only Brazil in terms of forest area lost. While the rate of forest loss reported by FAO was constant from 1990 through 2005 (1.87 Mha yr-1), the political, economic, social and environmental drivers of forest clearing changed at the close of the last century. We employed a consistent methodology and data source to quantify forest clearing from 1990 to 2000 and from 2000 to 2005. Results show a dramatic reduction in clearing from a 1990s average of 1.78 Mha yr-1 to an average of 0.71 Mha yr-1 from 2000 to 2005. However, annual forest cover loss indicator maps reveal a near-monotonic increase in clearing from a low in 2000 to a high in 2005. Results illustrate a dramatic downturn in forest clearing at the turn of the century followed by a steady resurgence thereafter to levels estimated to exceed 1 Mha yr-1 by 2005. The lowlands of Sumatra and Kalimantan were the site of more than 70% of total forest clearing within Indonesia for both epochs; over 40% of the lowland forests of these island groups were cleared from 1990 to 2005. The method employed enables the derivation of internally consistent, national-scale changes in the rates of forest clearing, results that can inform carbon accounting programs such as the Reducing Emissions from Deforestation and Forest Degradation in Developing Countries (REDD) initiative.

  3. Quantifying changes in the rates of forest clearing in Indonesia from 1990 to 2005 using remotely sensed data sets

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Matthew C; Potapov, Peter V; Pittman, Kyle [South Dakota State University, Brookings, SD 57007 (United States); Stehman, Stephen V [State University of New York, Syracuse, NY 13210 (United States); Arunarwati, Belinda [Indonesian Ministry of Forestry, Jakarta 10270 (Indonesia); Stolle, Fred, E-mail: Matthew.Hansen@sdstate.ed [World Resources Institute, Washington, DC 20002 (United States)

    2009-07-15

    Timely and accurate data on forest change within Indonesia is required to provide government, private and civil society interests with the information needed to improve forest management. The forest clearing rate in Indonesia is among the highest reported by the United Nations Food and Agriculture Organization (FAO), behind only Brazil in terms of forest area lost. While the rate of forest loss reported by FAO was constant from 1990 through 2005 (1.87 Mha yr{sup -1}), the political, economic, social and environmental drivers of forest clearing changed at the close of the last century. We employed a consistent methodology and data source to quantify forest clearing from 1990 to 2000 and from 2000 to 2005. Results show a dramatic reduction in clearing from a 1990s average of 1.78 Mha yr{sup -1} to an average of 0.71 Mha yr{sup -1} from 2000 to 2005. However, annual forest cover loss indicator maps reveal a near-monotonic increase in clearing from a low in 2000 to a high in 2005. Results illustrate a dramatic downturn in forest clearing at the turn of the century followed by a steady resurgence thereafter to levels estimated to exceed 1 Mha yr{sup -1} by 2005. The lowlands of Sumatra and Kalimantan were the site of more than 70% of total forest clearing within Indonesia for both epochs; over 40% of the lowland forests of these island groups were cleared from 1990 to 2005. The method employed enables the derivation of internally consistent, national-scale changes in the rates of forest clearing, results that can inform carbon accounting programs such as the Reducing Emissions from Deforestation and Forest Degradation in Developing Countries (REDD) initiative.

  4. System Re-set: High LET Radiation or Transient Musculoskeletal Disuse Cause Lasting Changes in Oxidative Defense Pathways Within Bone

    Science.gov (United States)

    Kumar, Akhilesh; Chatterjee, A.; Alwood, Joshua S.; Dvorochkin, Natalya; Almeida, Eduardo A. C.

    2011-01-01

    Six months post-IR, there were no notable changes in skeletal expression of 84 principal genes in the p53 signaling pathway due to low dose IR (0.5Gy), HU, or both. In contrast, numerous genes relevant to oxidative stress were regulated by the treatments, typically in a direction indicative of increased oxidative stress and impaired defense. IR and HU independently reduced (between 0.46 to 0.88 fold) expression levels of Noxa1, Gpx3, Prdx2, Prdx3, and Zmynd17. Surprisingly, transient HU alone (sham-irradiated) decreased expression of several redox-related genes (Gpx1,Gstk1, Prdx1, Txnrd2), which were not affected significantly by IR alone. Irradiation increased (1.13 fold) expression of a gene responsible for production of superoxides by neutrophils (NCF2). Of interest, only combined treatment with HU and IR led to increased expression levels of Ercc2, (1.19 fold), a DNA excision repair enzyme. Differences in gene expression levels may reflect a change in gene expression on a per cell basis, a shift in the repertoire of specific cell types within the tissue, or both. Serum nitrite/nitrate levels were elevated to comparable levels (1.6-fold) due to IR, HU or both, indicative of elevated systemic nitrosyl stress. CONCLUSIONS The magnitude of changes in skeletal expression of oxidative stress-related genes six months after irradiation and/or transient unloading tended to be relatively modest (0.46-1.15 fold), whereas the p53 pathway was not affected. The finding that many different oxidative stress-related genes differed from controls at this late time point implicates a generalized impairment of oxidative defense within skeletal tissue, which coincides with both profound radiation damage to osteoprogenitors/stem cells in bone marrow and impaired remodeling of mineralized tissue.

  5. Nature of changes in body composition indices in students during physical training using a set of athleticism.

    Directory of Open Access Journals (Sweden)

    Chernozub A.A.

    2011-06-01

    Full Text Available During investigations it was established that there are important changes in body composition parameters university students, who in the classroom with the general physical culture introduced by the training facilities with athleticism. The level indicators of body composition and dynamics are fully dependent on the employment structure, volume and intensity of physical exertion their focus. It is established that achieving the optimal performance of body composition may occur even with minimal training work. Planning sessions with physical cultures s light variation of volume and intensity of stress, achieves the required level of adaptation processes.

  6. Evidence for changes in stratospheric transport and mixing over the past three decades based on multiple data sets and tropical leaky pipe analysis

    OpenAIRE

    Ray, Eric A.; Moore, Fred L.; Rosenlof, Karen H.; Davis, Sean M.; Boenisch, Harald; Morgenstern, Olaf; Smale, Dan; Rozanov, Eugene; Hegglin, M.; Pitari, Gianni; Mancini, Eva; Braesicke, Peter; Butchart, Neal; Hardiman, Steven; Li, Feng

    2010-01-01

    Variability in the strength of the stratospheric Lagrangian mean meridional or Brewer-Dobson circulation and horizontal mixing into the tropics over the past three decades are examined using observations of stratospheric mean age of air and ozone. We use a simple representation of the stratosphere, the tropical leaky pipe (TLP) model, guided by mean meridional circulation and horizontal mixing changes in several reanalyses data sets and chemistry climate model (CCM) simulations, to help eluci...

  7. How the Second Delta Committee Set the Agenda for Climate Change Adaptation: A Dutch Case Study on Framing Strategies for Policy Change

    OpenAIRE

    Verduijn, S.H.; Meijerink, S.V.; Leroy, P.

    2012-01-01

    In 2008, the Second State Delta Committee, commissioned by the Dutch Secretary of Public Works and Water Management, provided suggestions on how to defend the Netherlands against the expected impacts of climate change, such as sea level rise, longer periods of drought, more intense periods of rainfall and additional land subsidence over the coming two hundred years (Veerman, 2008). In this paper we show that even though no crisis actually occurred, the Second Delta Committee succeeded in thre...

  8. How do modes of public engagement impact the development of robust data sets for climate change research?

    Science.gov (United States)

    Crimmins, T. M.; Rosemartin, A.

    2013-12-01

    Engaging non-scientists in data collection through formally organized programs, referred to as Public Participation in Scientific Research (PPSR), has proven to be a successful solution for providing data that are critical to natural resource management and to improving scientific understanding. The data sets that these programs yield often represent scales far beyond what science or management budgets could allow. The long-term success of such programs hinges on their abilities to maintain participants in generating high-quality, reliable data. We propose that participants' retention rates, activity level, and data quality may be related to the level of support and contact they receive from program staff or representatives. The USA National Phenology Network's national-scale plant and animal phenology observation program, Nature's Notebook, has been active since 2009. This program engages thousands of citizen scientists in tracking plant and animal life cycle activity over the course of the year. The program is designed such that all information participants need to register, learn the observation protocols and necessary details to participate, and submit observations is available online. Participants may contact USA-NPN staff for assistance as needed; otherwise, the primary form of contact that these participants receive is email newsletters including updates, data summaries, news tidbits, and relevant articles from USA-NPN staff. In an alternative model of participation, many established groups and organizations, including Master Gardener chapters, nature centers, arboreta, National Parks, and National Wildlife Refuges, have chosen to engage groups of individuals locally in tracking phenology using Nature's Notebook. Though these participants receive the same support and communications from USA-NPN staff, what sets these groups apart from individuals participating in Nature's Notebook independently is the additional face-to-face contact, interaction, and support

  9. HIV Transmission

    Science.gov (United States)

    ... Abroad Treatment Basic Statistics Get Tested Find an HIV testing site near you. Enter ZIP code or city Follow HIV/AIDS CDC HIV CDC HIV/AIDS See RSS | ... on HIV Syndicated Content Website Feedback HIV/AIDS HIV Transmission Language: English Español (Spanish) Recommend on Facebook ...

  10. Building a statistical emulator for prediction of crop yield response to climate change: a global gridded panel data set approach

    Science.gov (United States)

    Mistry, Malcolm; De Cian, Enrica; Wing, Ian Sue

    2015-04-01

    There is widespread concern that trends and variability in weather induced by climate change will detrimentally affect global agricultural productivity and food supplies. Reliable quantification of the risks of negative impacts at regional and global scales is a critical research need, which has so far been met by forcing state-of-the-art global gridded crop models with outputs of global climate model (GCM) simulations in exercises such as the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP)-Fastrack. Notwithstanding such progress, it remains challenging to use these simulation-based projections to assess agricultural risk because their gridded fields of crop yields are fundamentally denominated as discrete combinations of warming scenarios, GCMs and crop models, and not as model-specific or model-averaged yield response functions of meteorological shifts, which may have their own independent probability of occurrence. By contrast, the empirical climate economics literature has adeptly represented agricultural responses to meteorological variables as reduced-form statistical response surfaces which identify the crop productivity impacts of additional exposure to different intervals of temperature and precipitation [cf Schlenker and Roberts, 2009]. This raises several important questions: (1) what do the equivalent reduced-form statistical response surfaces look like for crop model outputs, (2) do they exhibit systematic variation over space (e.g., crop suitability zones) or across crop models with different characteristics, (3) how do they compare to estimates based on historical observations, and (4) what are the implications for the characterization of climate risks? We address these questions by estimating statistical yield response functions for four major crops (maize, rice, wheat and soybeans) over the historical period (1971-2004) as well as future climate change scenarios (2005-2099) using ISIMIP-Fastrack data for five GCMs and seven crop models

  11. The ultrastructural changes in the liver cells induced by high doses of Benzodiazepine Tranquilizing drugs: An experimental transmission electron microscopic study on male guinea pigs

    International Nuclear Information System (INIS)

    Benzodiazepines are tranquilizing psychotropic drugs. Unfortunately, despite their therapeutic benefits, they are illegally consumed in high doses by some addicts to reach a sedative, exhilarative and euphoria state similar to that produced by narcotic substances. The present study, using transmission electron microscope on male guinea pigs, aims to investigate the potential ultrastructural changes in the liver cells induced by the high doses of Benzodiazepines. Animals in three treated groups administrated a daily combined dose consisted of (10mg Alprazolam with 10mg Diazepam/day/animal) for three different treatment periods: 7, 15, and 25 days. The ultrastructural examination of the hepatocytes of the animals treated for 15 days showed limited changes in the form of marginal heterochromatine accompanied with marginal nucleoli enlargement. On the other hand, severe ultrastructural damages are observed in the animals treated for 25 days, which appeared in the following various patterns: fatty degeneration of the hepatocytes as indicated by the accumulation of large number of lipid droplets in the cytoplasm, marked nuclear atrophy in some necrotic hepatocytes, massive nuclear degeneration in other hepatocytes, mitochondrial damages in the form of cristea destruction accompanied with abnormal oval shape, massive lysis of the cytoplasmic organelles with severe plasma membrane rupture. In conclusion, the observed ultrastructural damages in the present study may refer to the potential hepatotoxic effects of the high dose of Benzodiazepins. It is recommended that much more official restrictions should be applied on the pharmacies sector to prevent any illegal selling of these drugs in order to prevent abusers from obtaining them, as unfortunately in some developing countries the illegal selling of these drugs is known to occur due to the absence of official control. (author)

  12. Evolution and change of He bubbles in He-containing Ti films upon thermal treatment studied by small-angle X-ray scattering and transmission electron microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Guangai [Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900 (China); College of Nuclear Science and Technology, University of Science and Technology of China, Hefei, 230029 (China); Wu, Erdong, E-mail: ewu@imr.ac.cn [National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Huang, Chaoqiang [Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900 (China); College of Nuclear Science and Technology, University of Science and Technology of China, Hefei, 230029 (China); Cheng, Chun [National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Yan, Guanyun [Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900 (China); Wang, Xiaolin [Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900 (China); College of Nuclear Science and Technology, University of Science and Technology of China, Hefei, 230029 (China); Liu, Shi [National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Tian, Qiang; Chen, Bo [Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900 (China); Wu, Zhonghua [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Liu, Yi; Wang, Jie [Institute of Shanghai Apply Physics, Chinese Academy of Sciences, Shanghai 201800 (China)

    2014-05-02

    Evolution and change of He bubbles in magnetron sputtering prepared He-containing Ti films under thermal treatment are studied by small-angle X-ray scattering (SAXS), transmission electron microscopy (TEM) and X-ray diffraction. Incorporation of He introduces a large number of He-vacancy clusters and some voids in the films, and significantly increases SAXS intensity and causes anisotropic scattering. The change of He induced defects during annealing is affected by thermal diffusion and migration of trapped He to the surface and between interfaces of He induced defects within the films. Annealing at 200 and 400 °C reduces intensity and anisotropy of SAXS, in accord with observed shrinking and disappearance of the voids. The simultaneous growth of non-uniformly distributed He bubbles to the sizes of 1–2 nm and a population level of 10{sup 5}/μm{sup 3} are detected in the temperature range. The changes are explained by migration and coalescence mechanisms, which requires low apparent activation energy. Inconsistence between TEM and SAXS observations is noted and attributed to thinning induced internal stress relaxation of TEM specimen. Remarkable enlargement of He bubbles, associated with increased SAXS intensity and fractal dimension, is observed after 600 °C annealing, indicating involvement of Ostwald Ripening (OR) mechanism. The OR process dominates at 800 °C, where the high temperature provides activation energy for accelerated He dissociation from small bubbles into larger ones, and generating textured microstructure and agglomerated bubble clusters. The inhomogeneous bubble size distribution observed at this temperature covers a broad range of about 10–50 nm and possessing a population density level of 10{sup 3}/μm{sup 3}. - Highlights: • Change of He bubbles in thermally treated Ti–He films is studied by SAXS and TEM. • SAXS reveals size distribution and fractional population of He bubbles in films. • He-vacancy clusters in Ti–He film

  13. Evolution and change of He bubbles in He-containing Ti films upon thermal treatment studied by small-angle X-ray scattering and transmission electron microscopy

    International Nuclear Information System (INIS)

    Evolution and change of He bubbles in magnetron sputtering prepared He-containing Ti films under thermal treatment are studied by small-angle X-ray scattering (SAXS), transmission electron microscopy (TEM) and X-ray diffraction. Incorporation of He introduces a large number of He-vacancy clusters and some voids in the films, and significantly increases SAXS intensity and causes anisotropic scattering. The change of He induced defects during annealing is affected by thermal diffusion and migration of trapped He to the surface and between interfaces of He induced defects within the films. Annealing at 200 and 400 °C reduces intensity and anisotropy of SAXS, in accord with observed shrinking and disappearance of the voids. The simultaneous growth of non-uniformly distributed He bubbles to the sizes of 1–2 nm and a population level of 105/μm3 are detected in the temperature range. The changes are explained by migration and coalescence mechanisms, which requires low apparent activation energy. Inconsistence between TEM and SAXS observations is noted and attributed to thinning induced internal stress relaxation of TEM specimen. Remarkable enlargement of He bubbles, associated with increased SAXS intensity and fractal dimension, is observed after 600 °C annealing, indicating involvement of Ostwald Ripening (OR) mechanism. The OR process dominates at 800 °C, where the high temperature provides activation energy for accelerated He dissociation from small bubbles into larger ones, and generating textured microstructure and agglomerated bubble clusters. The inhomogeneous bubble size distribution observed at this temperature covers a broad range of about 10–50 nm and possessing a population density level of 103/μm3. - Highlights: • Change of He bubbles in thermally treated Ti–He films is studied by SAXS and TEM. • SAXS reveals size distribution and fractional population of He bubbles in films. • He-vacancy clusters in Ti–He film transfer to bubbles and

  14. Novel infinitely Variable Transmission allowing efficient transmission ratio variations at rest

    OpenAIRE

    Everarts, Christophe; Dehez, Bruno; Ronsse, Renaud; Intelligent Robots and Systems (IROS), 2015 IEEE/RSJ International Conference on

    2015-01-01

    Recent studies showed that Continuously Variable Transmissions (CVT) and Infinitely Variable Transmissions (IVT) can considerably improve the locomotion efficiency in legged robot. A CVT is a transmission whose ratio can be continuously varied and an IVT is a transmission whose ratio can be continuously varied from positive to negative values. However, efficient use of such transmissions in walking applications requires changing the transmission ratio at a minimal energy cost, even at rest, i...

  15. Sub-nanosecond threshold-switching dynamics and set process of In3SbTe2 phase-change memory devices

    Science.gov (United States)

    Pandey, Shivendra Kumar; Manivannan, Anbarasu

    2016-06-01

    Phase-change materials show promising features for high-speed, non-volatile, random access memory, however achieving a fast electrical switching is a key challenge. We report here, the dependence of electrical switching dynamics including transient parameters such as delay time, switching time, etc., on the applied voltage and the set process of In3SbTe2 phase-change memory devices at the picosecond (ps) timescale. These devices are found to exhibit threshold-switching at a critical voltage called threshold-voltage, VT of 1.9 ± 0.1 V, having a delay time of 25 ns. Further, the delay time decreases exponentially to a remarkably smaller value, as short as 300 ± 50 ps upon increasing the applied voltage up to 1.1VT. Furthermore, we demonstrate a rapid phase-change behavior from amorphous (˜10 MΩ) to poly-crystalline (˜10 kΩ) phase using time-resolved measurements revealing an ultrafast set process, which is primarily initiated by the threshold-switching process within 550 ps for an applied voltage pulse with a pulse-width of 1.5 ns and an amplitude of 2.3 V.

  16. Identifying Malaria Transmission Foci for Elimination Using Human Mobility Data.

    Science.gov (United States)

    Ruktanonchai, Nick W; DeLeenheer, Patrick; Tatem, Andrew J; Alegana, Victor A; Caughlin, T Trevor; Zu Erbach-Schoenberg, Elisabeth; Lourenço, Christopher; Ruktanonchai, Corrine W; Smith, David L

    2016-04-01

    Humans move frequently and tend to carry parasites among areas with endemic malaria and into areas where local transmission is unsustainable. Human-mediated parasite mobility can thus sustain parasite populations in areas where they would otherwise be absent. Data describing human mobility and malaria epidemiology can help classify landscapes into parasite demographic sources and sinks, ecological concepts that have parallels in malaria control discussions of transmission foci. By linking transmission to parasite flow, it is possible to stratify landscapes for malaria control and elimination, as sources are disproportionately important to the regional persistence of malaria parasites. Here, we identify putative malaria sources and sinks for pre-elimination Namibia using malaria parasite rate (PR) maps and call data records from mobile phones, using a steady-state analysis of a malaria transmission model to infer where infections most likely occurred. We also examined how the landscape of transmission and burden changed from the pre-elimination setting by comparing the location and extent of predicted pre-elimination transmission foci with modeled incidence for 2009. This comparison suggests that while transmission was spatially focal pre-elimination, the spatial distribution of cases changed as burden declined. The changing spatial distribution of burden could be due to importation, with cases focused around importation hotspots, or due to heterogeneous application of elimination effort. While this framework is an important step towards understanding progressive changes in malaria distribution and the role of subnational transmission dynamics in a policy-relevant way, future work should account for international parasite movement, utilize real time surveillance data, and relax the steady state assumption required by the presented model. PMID:27043913

  17. Identifying Malaria Transmission Foci for Elimination Using Human Mobility Data

    Science.gov (United States)

    Ruktanonchai, Nick W.; DeLeenheer, Patrick; Tatem, Andrew J.; Alegana, Victor A.; Caughlin, T. Trevor; zu Erbach-Schoenberg, Elisabeth; Lourenço, Christopher; Ruktanonchai, Corrine W.; Smith, David L.

    2016-01-01

    Humans move frequently and tend to carry parasites among areas with endemic malaria and into areas where local transmission is unsustainable. Human-mediated parasite mobility can thus sustain parasite populations in areas where they would otherwise be absent. Data describing human mobility and malaria epidemiology can help classify landscapes into parasite demographic sources and sinks, ecological concepts that have parallels in malaria control discussions of transmission foci. By linking transmission to parasite flow, it is possible to stratify landscapes for malaria control and elimination, as sources are disproportionately important to the regional persistence of malaria parasites. Here, we identify putative malaria sources and sinks for pre-elimination Namibia using malaria parasite rate (PR) maps and call data records from mobile phones, using a steady-state analysis of a malaria transmission model to infer where infections most likely occurred. We also examined how the landscape of transmission and burden changed from the pre-elimination setting by comparing the location and extent of predicted pre-elimination transmission foci with modeled incidence for 2009. This comparison suggests that while transmission was spatially focal pre-elimination, the spatial distribution of cases changed as burden declined. The changing spatial distribution of burden could be due to importation, with cases focused around importation hotspots, or due to heterogeneous application of elimination effort. While this framework is an important step towards understanding progressive changes in malaria distribution and the role of subnational transmission dynamics in a policy-relevant way, future work should account for international parasite movement, utilize real time surveillance data, and relax the steady state assumption required by the presented model. PMID:27043913

  18. The Intergenerational Transmission of Voting Intentions in a Multiparty Setting: An Analysis of Voting Intentions and Political Discussion among 15-Year-Old Adolescents and Their Parents in Belgium

    Science.gov (United States)

    Hooghe, Marc; Boonen, Joris

    2015-01-01

    The intergenerational transmission of political orientations has been the topic of considerable research over the past few decades, but much of the evidence remains limited to two-party systems. In this study, we use data from the first wave of the Parent-Child Socialization Study conducted among 3,426 adolescents and their parents in the Flemish…

  19. Transcending Transmission

    DEFF Research Database (Denmark)

    Schoeneborn, Dennis; Trittin, Hannah

    2013-01-01

    Purpose – Extant research on corporate social responsibility (CSR) communication primarily relies on a transmission model of communication that treats organizations and communication as distinct phenomena. This approach has been criticized for neglecting the formative role of communication in the....... Organizations are stabilized by various non-human entities that “act” on their behalf. Accordingly, CSR communication should also take into account non-human agency and responsibility. Originality/value – This paper links the literature on CSR communication to broader debates in organizational communication...... studies and, in particular, to the CCO perspective. By applying the CCO view, it reconceptualizes CSR communication as a complex process of meaning negotiation....

  20. Impacts of Demand-Side Resources on Electric Transmission Planning

    Energy Technology Data Exchange (ETDEWEB)

    Hadley, Stanton W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sanstad, Alan H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-01-01

    Will demand resources such as energy efficiency (EE), demand response (DR), and distributed generation (DG) have an impact on electricity transmission requirements? Five drivers for transmission expansion are discussed: interconnection, reliability, economics, replacement, and policy. With that background, we review the results of a set of transmission studies that were conducted between 2010 and 2013 by electricity regulators, industry representatives, and other stakeholders in the three physical interconnections within the United States. These broad-based studies were funded by the US Department of Energy and included scenarios of reduced load growth due to EE, DR, and DG. While the studies were independent and used different modeling tools and interconnect-specific assumptions, all provided valuable results and insights. However, some caveats exist. Demand resources were evaluated in conjunction with other factors, and limitations on transmission additions between scenarios made understanding the role of demand resources difficult. One study, the western study, included analyses over both 10- and 20-year planning horizons; the 10-year analysis did not show near-term reductions in transmission, but the 20-year indicated fewer transmission additions, yielding a 36percent capital cost reduction. In the eastern study the reductions in demand largely led to reductions in local generation capacity and an increased opportunity for low-cost and renewable generation to export to other regions. The Texas study evaluated generation changes due to demand, and is in the process of examining demand resource impacts on transmission.

  1. An optical filter with angular selectivity of the light transmission

    Science.gov (United States)

    Zakirullin, Rustam S.

    2015-09-01

    Features of the application of a novel optical filter with angular selectivity of the light transmission to architectural glazing are considered. The filter consists of a sheet transparent substrate with thin-film grating layers on both surfaces. The gratings formed by directionally transmissive strips, alternating with absorptive, reflective, or scattering strips. Their relative position on the input and output surfaces provides angular selectivity of the directional light transmission - as the incidence angle changes, the proportion of radiation that passes through both gratings of the filter also changes. Chromogenic materials currently used in the laminated smart windows, providing control over the intensity and spectrum of the transmitted solar radiation, cannot achieve the selective regulation on the ranges of incidence angles. Such a regulation requires the use of additional daylight-redirecting devices, especially blinds, to dynamically adapt to the position of the sun. The grating optical filter provides angular selectivity of the light transmission of a window without such devices. The features of using this filter in the single and double glazed windows are described. A graphic analytical calculation method is proposed for estimating the effect of geometrical and optical parameters of the filter on the angular characteristics of the light transmission. An algorithm to optimize filtering solar radiation taking into account the geographical coordinates of terrain, time of day and year and the orientation of the window to the cardinal is set. An algorithm to calculating geometrical parameters of the filter with pre-specified characteristics of the light transmission is obtained.

  2. Hematological changes in women and infants exposed to an AZT-containing regimen for prevention of mother-to-child-transmission of HIV in Tanzania.

    Directory of Open Access Journals (Sweden)

    Judith Ziske

    Full Text Available INTRODUCTION: Tanzanian guidelines for prevention of mother-to-child-transmission of HIV (PMTCT recommend an antiretroviral combination regimen involving zidovudine (AZT during pregnancy, single-dosed nevirapine at labor onset, AZT plus Lamivudine (3TC during delivery, and AZT/3TC for 1-4 weeks postpartum. As drug toxicities are a relevant concern, we assessed hematological alterations in AZT-exposed women and their infants. METHODS AND MATERIALS: A cohort of HIV-positive women, either with AZT intake (n = 82, group 1 or without AZT intake (n = 62, group 2 for PMTCT during pregnancy, was established at Kyela District Hospital, Tanzania. The cohort also included the infants of group 1 with an in-utero AZT exposure ≥4 weeks, receiving AZT for 1 week postpartum (n = 41, and infants of group 2 without in-utero AZT exposure, receiving a prolonged 4-week AZT tail (n = 58. Complete blood counts were evaluated during pregnancy, birth, weeks 4-6 and 12. RESULTS: For women of group 1 with antenatal AZT intake, we found a statistically significant decrease in hemoglobin level, red blood cells, white blood cells, granulocytes, as well as an increase in red cell distribution width and platelet count. At delivery, the median red blood cell count was significantly lower and the median platelet count was significantly higher in women of group 1 compared to group 2. At birth, infants from group 1 showed a lower median hemoglobin level and granulocyte count and a higher frequency of anemia and granulocytopenia. At 4-6 weeks postpartum, the mean neutrophil granulocyte count was significantly lower and neutropenia was significantly more frequent in infants of group 2. CONCLUSIONS: AZT exposure during pregnancy as well as after birth resulted in significant hematological alterations for women and their newborns, although these changes were mostly mild and transient in nature. Research involving larger cohorts is needed to further analyze the impact

  3. Control of schistosomiasis transmission

    OpenAIRE

    Luiz C. de S. Dias; Oswaldo Marçal Jr.; GLASSER Carmem M.

    1995-01-01

    Despite the success of control programmes, schistosomiasis is still a serious public health problem in the world. More than 70 countries where 200 million individuals are evaluated to be infected of a total 600 million at risk. Though there have been important local success in the control of transmission, globally the infection has increased. Economic constrains in developing countries, environmental changes associated with migration and water resources development have been blocking the prog...

  4. Mechanisms, Transmissions and Applications

    CERN Document Server

    Corves, Burkhard

    2012-01-01

    The first Workshop on Mechanisms, Transmissions and Applications -- MeTrApp-2011 was organized by the Mechatronics Department at the Mechanical Engineering Faculty, “Politehnica” University of Timisoara, Romania, under the patronage of the IFToMM Technical Committees Linkages and Mechanical Controls and Micromachines. The workshop brought together researchers and students who work in disciplines associated with mechanisms science and offered a great opportunity for scientists from all over the world to present their achievements, exchange innovative ideas and create solid international links, setting the trend for future developments in this important and creative field. The topics treated in this volume are mechanisms and machine design, mechanical transmissions, mechatronic and biomechanic applications, computational and experimental methods, history of mechanism and machine science and teaching methods.

  5. Evidence for changes in stratospheric transport and mixing over the past three decades based on multiple data sets and tropical leaky pipe analysis

    Science.gov (United States)

    Ray, Eric A.; Moore, Fred L.; Rosenlof, Karen H.; Davis, Sean M.; Boenisch, Harald; Morgenstern, Olaf; Smale, Dan; Rozanov, Eugene; Hegglin, Michaela; Pitari, Gianni; Mancini, Eva; Braesicke, Peter; Butchart, Neal; Hardiman, Steven; Li, Feng; Shibata, Kiyotaka; Plummer, David A.

    2010-11-01

    Variability in the strength of the stratospheric Lagrangian mean meridional or Brewer-Dobson circulation and horizontal mixing into the tropics over the past three decades are examined using observations of stratospheric mean age of air and ozone. We use a simple representation of the stratosphere, the tropical leaky pipe (TLP) model, guided by mean meridional circulation and horizontal mixing changes in several reanalyses data sets and chemistry climate model (CCM) simulations, to help elucidate reasons for the observed changes in stratospheric mean age and ozone. We find that the TLP model is able to accurately simulate multiyear variability in ozone following recent major volcanic eruptions and the early 2000s sea surface temperature changes, as well as the lasting impact on mean age of relatively short-term circulation perturbations. We also find that the best quantitative agreement with the observed mean age and ozone trends over the past three decades is found assuming a small strengthening of the mean circulation in the lower stratosphere, a moderate weakening of the mean circulation in the middle and upper stratosphere, and a moderate increase in the horizontal mixing into the tropics. The mean age trends are strongly sensitive to trends in the horizontal mixing into the tropics, and the uncertainty in the mixing trends causes uncertainty in the mean circulation trends. Comparisons of the mean circulation and mixing changes suggested by the measurements with those from a recent suite of CCM runs reveal significant differences that may have important implications on the accurate simulation of future stratospheric climate.

  6. Measuring Post-Partum Haemorrhage in Low-Resource Settings: The Diagnostic Validity of Weighed Blood Loss versus Quantitative Changes in Hemoglobin

    Science.gov (United States)

    Atukunda, Esther Cathyln; Mugyenyi, Godfrey Rwambuka; Obua, Celestino; Atuhumuza, Elly Bronney; Musinguzi, Nicholas; Tornes, Yarine Fajardo; Agaba, Amon Ganaafa; Siedner, Mark Jacob

    2016-01-01

    Background Accurate estimation of blood loss is central to prompt diagnosis and management of post-partum hemorrhage (PPH), which remains a leading cause of maternal mortality in low-resource countries. In such settings, blood loss is often estimated visually and subjectively by attending health workers, due to inconsistent availability of laboratory infrastructure. We evaluated the diagnostic accuracy of weighed blood loss (WBL) versus changes in peri-partum hemoglobin to detect PPH. Methods Data from this analysis were collected as part of a randomized controlled trial comparing oxytocin with misoprostol for PPH (NCT01866241). Blood samples for complete blood count were drawn on admission and again prior to hospital discharge or before blood transfusion. During delivery, women were placed on drapes and had pre-weighed sanitary towels placed around their perineum. Blood was then drained into a calibrated container and the sanitary towels were added to estimate WBL, where each gram of blood was estimated as a milliliter. Sensitivity, specificity, negative and positive predictive values (PPVs) were calculated at various blood volume loss and time combinations, and we fit receiver-operator curves using blood loss at 1, 2, and 24 hours compared to a reference standard of haemoglobin decrease of >10%. Results A total of 1,140 women were enrolled in the study, of whom 258 (22.6%) developed PPH, defined as a haemoglobin drop >10%, and 262 (23.0%) had WBL ≥500mL. WBL generally had a poor sensitivity for detection of PPH (85%) in high prevalence settings when WBL exceeds 750mL. Conclusion WBL has poor sensitivity but high specificity compared to laboratory-based methods of PPH diagnosis. These characteristics correspond to a high PPV in areas with high PPH prevalence. Although WBL is not useful for excluding PPH, this low-cost, simple and reproducible method is promising as a reasonable method to identify significant PPH in such settings where quantifiable red cell

  7. Mode of delivery in HIV-infected pregnant women and prevention of mother-to-child transmission: changing practices in Western Europe

    DEFF Research Database (Denmark)

    NN, NN; Boer, K; England, K;

    2010-01-01

    The aim of the study was to examine temporal and geographical patterns of mode of delivery in the European Collaborative Study (ECS), identify factors associated with elective caesarean section (CS) delivery in the highly active antiretroviral therapy (HAART) era and explore associations between ...... mode of delivery and mother-to-child transmission (MTCT)....

  8. Quantum Contact Transmission

    Institute of Scientific and Technical Information of China (English)

    崔迪

    2015-01-01

    Abstract:Quantum transmission is based on quantum entanglement, which is a kind of the phenomenon of quantum mechanics. Quantum object refers to two or more between the localized, the classic strong correlation. When two object quantum entanglement in the quantum state is not independent, but related, and the correlation distance, a pair of electronic of entanglement state, no matter how far apart, they spin direction will remain an up and a down. If one of the electronic spin direction is changed, another of the electron spin direction wil follow to change immediately.

  9. High intensity interval training in a real world setting: a randomized controlled feasibility study in overweight inactive adults, measuring change in maximal oxygen uptake.

    Directory of Open Access Journals (Sweden)

    Helen Lunt

    Full Text Available BACKGROUND: In research clinic settings, overweight adults undertaking HIIT (high intensity interval training improve their fitness as effectively as those undertaking conventional walking programs but can do so within a shorter time spent exercising. We undertook a randomized controlled feasibility (pilot study aimed at extending HIIT into a real world setting by recruiting overweight/obese, inactive adults into a group based activity program, held in a community park. METHODS: Participants were allocated into one of three groups. The two interventions, aerobic interval training and maximal volitional interval training, were compared with an active control group undertaking walking based exercise. Supervised group sessions (36 per intervention were held outdoors. Cardiorespiratory fitness was measured using VO2max (maximal oxygen uptake, results expressed in ml/min/kg, before and after the 12 week interventions. RESULTS: On ITT (intention to treat analyses, baseline (N = 49 and exit (N = 39 [Formula: see text]O2 was 25.3±4.5 and 25.3±3.9, respectively. Participant allocation and baseline/exit VO2max by group was as follows: Aerobic interval training N =  16, 24.2±4.8/25.6±4.8; maximal volitional interval training N = 16, 25.0±2.8/25.2±3.4; walking N = 17, 26.5±5.3/25.2±3.6. The post intervention change in VO2max was +1.01 in the aerobic interval training, -0.06 in the maximal volitional interval training and -1.03 in the walking subgroups. The aerobic interval training subgroup increased VO2max compared to walking (p = 0.03. The actual (observed, rather than prescribed time spent exercising (minutes per week, ITT analysis was 74 for aerobic interval training, 45 for maximal volitional interval training and 116 for walking (p =  0.001. On descriptive analysis, the walking subgroup had the fewest adverse events. CONCLUSIONS: In contrast to earlier studies, the improvement in cardiorespiratory fitness in a

  10. Long-term change and stability in the California Current System: lessons from CalCOFI and other long-term data sets

    Science.gov (United States)

    Rebstock, Ginger A.

    2003-08-01

    The California Current System (CCS) is a highly variable system, both spatially and temporally, that is strongly affected by low-frequency climatic fluctuations. This paper reviews evidence for long-term (decadal-scale) change in the physics and biology of the CCS over the last 50-100 years, as well as evidence for stability in planktonic community structure and long-term persistence of populations. Increases in water temperature, thermocline depth and stratification in the CCS have been accompanied by changes in populations of kelp, diatoms, foraminifera, radiolarians, intertidal invertebrates, zooplankton, fish and seabirds. However, there is also evidence for stability in assemblages of larval fish, calanoid copepods and radiolarians. Statistical averaging (the portfolio effect) may explain some aspects of stability in assemblages. Advection of planktonic populations may account for rapid recovery of biomass and dominance structure following perturbations such as strong El Niño events. Planktonic populations in the CCS may be adapted to large-scale biotic and abiotic variability, through a combination of advection of populations and life history traits. Several lessons may be learned from the California Cooperative Oceanic Fisheries Investigations and other long-term data sets: (1) long time series are needed to understand the dynamics of the ecosystem; (2) life histories are important determinants of species responses to environmental forcing, even in the plankton; and (3) the CCS is simultaneously variable and stable, and these properties are not necessarily in conflict.

  11. Tree sets

    OpenAIRE

    Diestel, Reinhard

    2015-01-01

    We study an abstract notion of tree structure which generalizes tree-decompositions of graphs and matroids. Unlike tree-decompositions, which are too closely linked to graph-theoretical trees, these `tree sets' can provide a suitable formalization of tree structure also for infinite graphs, matroids, or set partitions, as well as for other discrete structures, such as order trees. In this first of two papers we introduce tree sets, establish their relation to graph and order trees, and show h...

  12. Intertwined arbovirus transmission activity: reassessing the transmission cycle paradigm.

    OpenAIRE

    LuisAdrianDiaz

    2013-01-01

    Arboviruses are emerging/reemerging infectious agents worldwide. The factors within this scenario include vector and host population fluctuations, climatic changes, anthropogenic activities that disturb ecosystems, an increase in international flights, human mobility, and genetic mutations that allow spill-over phenomenon. Arboviruses are maintained by biologic transmission among vectors and hosts. Sometimes this biological transmission is specific and includes one vector and host species suc...

  13. Changes of cholinergic markers and muscarinic transmission in young and aged APP/PS1 double transgenic mice model of Alzheimer´s disease

    Czech Academy of Sciences Publication Activity Database

    Machová, Eva; Jakubík, Jan; Michal, Pavel; Oksman, M.; Iivonen, H.; Tanila, H.; Doležal, Vladimír

    Fyziologický ústav AV ČR, v. v. i.. Roč. 56, č. 3 (2007), 20P-21P ISSN 0862-8408. [Fyziologické dny /83./. 06.02.2007-08.02.2007, Brno] R&D Projects: GA MŠk(CZ) LC554; GA AV ČR IAA5011206 Institutional research plan: CEZ:AV0Z50110509 Keywords : cpr1 * cholinergic markers * muscarinic transmission * Alzheimer ´s disease Subject RIV: FH - Neurology

  14. Study on connectivity of water-conducting features from the spatial changes of transmissivity based on the hydraulic packer testing data

    International Nuclear Information System (INIS)

    Transformation of transmissivity from derivative of pressure transient data obtained from hydraulic packer testing has applied to the testing data from fractured rock of Mizunami site Japan and Onkalo site Finland. The results show hydrogeological conceptual model for the tested area such as connectivity and continuity of the water-conducting features could be established by the proposed methodology. This method would provide useful information to the hydrogeological and transport modeling and simulation. (author)

  15. Development of primer sets that can verify the enrichment of histone modifications, and their application to examining vernalization-mediated chromatin changes in Brassica rapa L.

    Science.gov (United States)

    Kawanabe, Takahiro; Osabe, Kenji; Itabashi, Etsuko; Okazaki, Keiichi; Dennis, Elizabeth S; Fujimoto, Ryo

    2016-07-20

    Epigenetic regulation is crucial for the development of plants and for adaptation to a changing environment. Recently, genome-wide profiles of histone modifications have been determined by a combination of chromatin immunoprecipitation (ChIP) and genomic tiling arrays (ChIP on chip) or ChIP and high-throughput sequencing (ChIP-seq) in species including Arabidopsis thaliana, rice and maize. Validation of ChIP analysis by PCR or qPCR using positive and negative regions of histone modification is necessary. In contrast, information about histone modifications is limited in Chinese cabbage, Brassica rapa. The aim of this study was to develop positive and negative control primer sets for H3K4me3 (trimethylation of the 4(th) lysine of H3), H3K9me2, H3K27me3 and H3K36me3 in B. rapa. The expression and histone modification of four FLC paralogs in B. rapa, before and after vernalization, were examined using the method developed here. After vernalization, expression of all four BrFLC genes was reduced, and accumulation of H3K27me3 was observed in three of them. As with A. thaliana, the vernalization response and stability of FLC repression correlated with the accumulation of H3K27me3. These results suggest that the epigenetic state during vernalization is important for high bolting resistance in B. rapa. The positive and negative control primer sets developed here revealed positive and negative histone modifications in B. rapa that can be used as a control for future studies. PMID:27074983

  16. Accounting-related transmission issues

    International Nuclear Information System (INIS)

    Various initiatives have been undertaken by the Federal Energy Regulatory Commission (FERC) to deregulate wholesale electric energy markets. These initiatives have focused on restructuring the transmission systems in the US and recently have culminated in a proposal requiring formation of and participation in regional transmission organizations. The overall form of regulation selected to determine rates for transmission entities as well as underlying regulatory decisions reached on key issues will have profound implications for transmission entities. For example, traditional cost-based regulation would require one set of accounting and reporting rules, while incentive-based regulation may not be subject to those same rules. An overview of some of the major accounting and financial reporting issues that will need to be considered is presented

  17. ECOLOGICAL CHANGE AS A FACTOR IN RENEWED MALARIA TRANSMISSION IN AN ERADICATED AREA. A LOCALIZED OUTBREAK OF A. AQUASALIS-TRANSMITTED MALARIA ON THE DEMERARA RIVER ESTUARY, BRITISH GUIANA, IN THE FIFTEENTH YEAR OF A. DARLINGI AND MALARIA ERADICATION.

    Science.gov (United States)

    GIGLIOLI, G

    1963-01-01

    In British Guiana, the successful eradication of Anopheles darlingi and malaria from the coastal areas has caused a very rapid increase in the population and has favoured a considerable social and economic improvement and expansion of both agriculture and industry. Housing and industrial developments and the constantly expanding rice cultivation have taken over most of the accessible pasture-lands, displacing the livestock which previously abounded around villages and settlements. Mechanization on the roads and in the fields increases daily, and the horse, the mule, the donkey and the ploughing oxen are gradually becoming obsolete.In some areas these changes have already caused such an upset in the balance between the human and the livestock population that A. aquasalis, a very abundant species all along the coast, but until recently entirely "fixed" by the livestock population, is now shifting its attention from livestock to man. On the Demerara river estuary, an area where malaria transmission was interrupted sixteen years ago and where eradication has been continually maintained, this mosquito has been responsible for a sharp, but localized, outbreak of P. vivax malaria. An entirely new epidemiological problem thus presents itself.Environmental changes, introduced and fostered by successful malaria eradication, may thus cause an anopheline species, potentially capable of malaria transmission, but originally inactive and harmless as a vector, to alter its feeding habits and thereby renew transmission. The immediate and long-term significance of some secondary and potential vectors may therefore require renewed evaluation in the planning of malaria eradication campaigns. PMID:14056265

  18. Digital data set of water-level changes in the High Plains aquifer in parts of Colorado, Kansas, Nebraska, New Mexico, Oklahoma, South Dakota, Texas, and Wyoming, 1980 to 1994

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digital water-level-change contour for the High Plains aquifer in the Central United States, 1980 to 1994. The High Plains aquifer extends...

  19. Digital data set of water-level changes in the High Plains aquifer in parts of Colorado, Kansas, Nebraska, New Mexico, Oklahoma, South Dakota, Texas, and Wyoming, 1980 to 1996

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digital water-level-change contours for the High Plains aquifer in the Central United States, 1980 to 1996. The High Plains aquifer...

  20. Digital data set of water-level changes in the High Plains aquifer in parts of Colorado, Kansas, Nebraska, New Mexico, Oklahoma, South Dakota, Texas, and Wyoming, 1980 to 1995

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digital water-level-change contours for the High Plains aquifer in the central United States, 1980 to 1995. The High Plains aquifer...

  1. Chebotarev Sets

    CERN Document Server

    Kisilevsky, Hershy

    2011-01-01

    We consider the problem of determining whether a set of primes, or, more generally, prime ideals in a number field, can be realized as a finite union of residue classes, or of Frobenius conjugacy classes. We give criteria for a set to be realized in this manner, and show that the subset of primes consisting of every other prime cannot be expressed in this way, even if we allow a finite number of exceptions.

  2. Price transmission in the agri-food value chain - from a farmer perspective

    DEFF Research Database (Denmark)

    Hansen, Henning Otte

    2015-01-01

    Price transmission in the agri-food value chain - when changes in one price cause another price downstream to change - is an important issue for farmers, markets and the economy as an efficient market price setting is crucial for all market players. However, there are numerous examples of price...... imperfect price transmission, to determine some of the underlying causes and driving forces behind the phenomenon as well as highlight farmers’ interests, role and opportunities in connection with ensuring more effective price transmission. On the basis of an example of a grain-bread value chain, it is...... apparent that the price increases downstream occur relatively quickly and are significant, while the price decreases become smaller and significantly slower as one moves forward in the value chain. Both lags and asymmetric price transmission are present. The example also shows that bread prices increase...

  3. Zika and Sexual Transmission

    Science.gov (United States)

    ... Address What's this? Submit What's this? Submit Button Zika and Sexual Transmission Language: English Español Português ... Healthcare Providers: Sexual Transmission of Zika Basics of Zika Virus and Sex Transmission Zika can be passed ...

  4. The Monetary Transmission Mechanism: An Empirical Framework

    OpenAIRE

    Taylor, John B.

    1995-01-01

    This paper provides an overview of the monetary transmission mechanism describing the impact of changes in monetary policy on real GDP. Changes in financial market prices--including long-term interest rates and exchange rates--are the main vehicle for the transmission of policy. The framework incorporates rational expectations and policy rules. It is empirical and appears to fit the facts well.

  5. Available transmission capacity assessment

    Directory of Open Access Journals (Sweden)

    Škokljev Ivan

    2012-01-01

    Full Text Available Effective power system operation requires the analysis of vast amounts of information. Power market activities expose power transmission networks to high-level power transactions that threaten normal, secure operation of the power system. When there are service requests for a specific sink/source pair in a transmission system, the transmission system operator (TSO must allocate the available transfer capacity (ATC. It is common that ATC has a single numerical value. Additionally, the ATC must be calculated for the base case configuration of the system, while generation dispatch and topology remain unchanged during the calculation. Posting ATC on the internet should benefit prospective users by aiding them in formulating their requests. However, a single numerical value of ATC offers little for prospect for analysis, planning, what-if combinations, etc. A symbolic approach to the power flow problem (DC power flow and ATC offers a numerical computation at the very end, whilst the calculation beforehand is performed by using symbols for the general topology of the electrical network. Qualitative analysis of the ATC using only qualitative values, such as increase, decrease or no change, offers some new insights into ATC evaluation, multiple transactions evaluation, value of counter-flows and their impact etc. Symbolic analysis in this paper is performed after the execution of the linear, symbolic DC power flow. As control variables, the mathematical model comprises linear security constraints, ATC, PTDFs and transactions. The aim is to perform an ATC sensitivity study on a five nodes/seven lines transmission network, used for zonal market activities tests. A relatively complicated environment with twenty possible bilateral transactions is observed.

  6. Sundhedsfremmende settings

    DEFF Research Database (Denmark)

    Magne, Jeanette

    2012-01-01

    Dette kapitel giver en indføring i settingsperspektivet i sundhedsfremme og et indblik i anvendelsen af begrebet ’settings for sundhedsfremme’ i en sundhedspædagogisk sammenhæng. Kapitlet viser, hvordan elementer i de miljøer og kontekster, som mennesker tager del i i dagligdagen, har betydning for...... sundhed. Disse miljøer, også kaldet settings, kan være skoler, hospitaler, arbejdspladser, uddannelsesinstitutioner og lokalområder eller andre steder, hvor mennesker lever deres hverdagsliv. På grundlag af kapitlet kan læseren: • få indsigt i sundhedens forskellige determinanter og dermed mulighed for...... kritisk at vurdere grundlaget for sundhedspædagogisk intervention • reflektere settingsperspektivet i sundhedsfremme som et teoretisk skifte fra at se sundhed som bundet til individuel risikoadfærd til at anskue settings som komplekse fænomener med afgørende betydning for medlemmernes sundhed – uanset...

  7. Survey of Transmission Cost Allocation Methodologies for Regional Transmission Organizations

    Energy Technology Data Exchange (ETDEWEB)

    Fink, S.; Porter, K.; Mudd, C.; Rogers, J.

    2011-02-01

    The report presents transmission cost allocation methodologies for reliability transmission projects, generation interconnection, and economic transmission projects for all Regional Transmission Organizations.

  8. Change in Health-Related Quality of Life among Pulmonary Tuberculosis Patients at Primary Health Care Settings in South Africa: A Prospective Cohort Study

    Science.gov (United States)

    Louw, Julia S.; Mabaso, Musawenkosi; Peltzer, Karl

    2016-01-01

    Introduction Pulmonary tuberculosis (TB) remains a major public health challenge in South Africa. However, little attention is paid to the impact of health related quality of life (HRQL) among TB patients at the beginning and at the end of TB treatment. This study assesses factors associated with HRQL among tuberculosis patients in three high risk provinces in South Africa. Methods A prospective cohort study was conducted at primary health care settings. Patients completed the HRQL social functioning (SF)-12 health survey. Comparison of Physical Health Summary Score (PCS) and Mental Health Summary Score (MCS) was assessed at 6 months after treatment. Generalized estimating equations (GEEs) were used to examine the factors associated with changes in HRQL. Results In all patients, after 6 months of treatment there was a significant improvement in HRQL with the biggest increase in the PCS. A higher educational qualification had a strong significant positive effect on the mental HRQL. Psychological distress showed a significant negative association with physical and mental HRQL after six months. Permanent residence showed a significant positive association with mental HRQL among TB patients compared to those living in shack/traditional dwellings. Rating ones health as being good and fair/poor was significantly associated with poor physical HRQL. Twenty drinks or more in the past month had a significant negative effect on the physical HRQL. Conclusion The findings suggest that programmes targeted at improving TB treatment success should have specific interventions for patients with low educational background, impoverished households/communities and those with hazardous or harmful alcohol use. PMID:27137914

  9. Setting Objectives

    Science.gov (United States)

    Elkins, Aaron J.

    1977-01-01

    The author questions the extent to which educators have relied on "relevance" and learner participation in objective-setting in the past decade. He describes a useful approach to learner-oriented evaluation in which content relevance was not judged by participants until after they had been exposed to it. (MF)

  10. Integration of prevention of mother-to-child transmission of HIV (PMTCT postpartum services with other HIV care and treatment services within the maternal and child health setting in Zimbabwe, 2012.

    Directory of Open Access Journals (Sweden)

    Katherine Wiegert

    Full Text Available We assessed the integration of PMTCT services during the postpartum period including early infant diagnosis of HIV (EID and adult and pediatric antiretroviral therapy (ART in maternal and child health (MCH facilities in Zimbabwe.From August to December 2012 we conducted a cross-sectional survey of a nationally representative sample of 151 MCH facilities. A questionnaire was used to survey each site about staff training, dried blood spot sample (DBS collection, turnaround time (TAT for test results, PMTCT services, and HIV care and treatment linkages for HIV-infected mothers and children and HIV-exposed infants. Descriptive analyses were used. Of the facilities surveyed, all facilities were trained on DBS collection and 92% responded. Approximately, 99% of responding facilities reported providing DBS collection and a basic HIV-exposed infant service package including EID, extended nevirapine prophylaxis, and use of cotrimoxazole. DBS collection was integrated with immunisations at 83% of facilities, CD4 testing with point-of-care machines was available at 37% of facilities, and ART for both mothers and children was provided at 27% of facilities. More than 80% of facilities reported that DBS test results take >4 weeks to return; TAT did not have a direct association with any specific type of transport, distance to the lab, or intermediate stops for data to travel.Zimbabwe has successfully scaled up and integrated the national EID and PMTCT programs into the existing MCH setting. The long TAT of infant DBS test results and the lack of integrated ART programs in the MCH setting could reduce effectiveness of the national PMTCT and ART programs. Addressing these important gaps will support successful implementation of the 2014 Zimbabwe's PMTCT guidelines under which all HIV-infected pregnant and breastfeeding women will be offered life-long ART and decentralized ART care.

  11. Microstructure changes during non-conventional heat treatment of thin Ni-Ti wires by pulsed electric current studied by transmission electron microscopy

    International Nuclear Information System (INIS)

    Transmission electron microscopy, electrical resistivity measurements and mechanical testing were employed to investigate the evolution of microstructure and functional superelastic properties of 0.1 mm diameter as-drawn Ni-Ti wires subjected to a non-conventional heat treatment by controlled electric pulse currents. This method enables a better control of the recovery and recrystallization processes taking place during the heat treatment and accordingly a better control on the final microstructure. Using a stepwise approach of millisecond pulse annealing, it is shown how the microstructure evolves from a severely deformed state with no functional properties to an optimal nanograined microstructure (20-50 nm) that is partially recovered through polygonization and partially recrystallized and that has the best functional properties. Such a microstructure is highly resistant against dislocation slip upon cycling, while microstructures annealed for longer times and showing mostly recrystallized grains were prone to dislocation slip, particularly as the grain size exceeds 200 nm.

  12. "I Am Who I Am Because of Here!": School Settings as a Mechanism of Change in Establishing High-Risk Adolescents' Academic Identities

    Science.gov (United States)

    Brown, Elizabeth Levine; Kanny, M. Allison; Johnson, Blake

    2014-01-01

    A growing body of research considers the role of school settings in supporting adolescents' social-emotional and behavioral development through instructional, social, and organizational practices (Eccles & Roeser, 2009). Recent lines of inquiry have begun to investigate individual aspects of the school setting and their influence in…

  13. The evidence of mother to child transmission of hepatitis B virus infection in Pakistan and the need for hepatitis B immunization policy change

    International Nuclear Information System (INIS)

    Objective: To establish the hepatitis B surface antigen and hepatitis B 'e' antigen seroprevalence of mothers and their children aged 6-36 months and to assess the risk of hepatitis B transmission occurring in infants born to hepatitis B surface antigen positive mothers in Pakistan. Methods: Mothers and their children were selected from eight districts of three provinces that have been identified as high hepatitis B prevalence areas between May 2010 to February 2011. Ages of the children and their vaccination status were obtained from the lady health workers' registers and also verified from the mothers. Five ml of blood was drawn from all the children and their mothers for testing. All sera were tested for anti-hepatitis B. Those found negative were run for HBsAg the sueface antigen and those positive for it were further run for hepatitis B 'e' antigen. All tests were run on Abbott machine using chemiluminesence method. EPI-info 12 was used for statistical purposes. Results: A total of 1561 mothers and their 1612 children were tested. Among the mothers, 590 (37.8%) were hepatitis B antibody positive. Remaining 971 (62.2%) samples were tested for surface antigen and 123 (12.7%) were found positive of which 27 (22%) showed HBeAg positivity. Out of 1612 children tested, 975 (60.5%) were positive. Remaining 637 (39.5%) were tested for surface antigen and 49 (8%) were found positive of which 24 (49%) were HBeAg positive with a perinatal hepatitis B virus transmission rate of 5.4% by 12 months of age. Of the 123 surface antigen positive mothers, 18 (14.6%) had children who were also positive, while of the 1489 children born to the 1438 surface antigen negative mothers, 31 (2.1%) were positive. Children born to surface antigen positive mothers had eight times higher risk of getting hepatitis B virus infection and the risk rose to 17 times if the mother was also HBeAg positive. Hepatitis B vaccination record showed that 1229 (76.25%) children were vaccinated at six weeks

  14. Transmission of Neurodegenerative Disorders Through Blood Transfusion

    DEFF Research Database (Denmark)

    Edgren, Gustaf; Hjalgrim, Henrik; Rostgaard, Klaus;

    2016-01-01

    Background: The aggregation of misfolded proteins in the brain occurs in several neurodegenerative disorders. Aberrant protein aggregation is inducible in rodents and primates by intracerebral inoculation. Possible transfusion transmission of neurodegenerative diseases has important public health...... implications. Objective: To investigate possible transfusion transmission of neurodegenerative disorders. Design: Retrospective cohort study. Setting: Nationwide registers of transfusions in Sweden and Denmark. Participants: 1 465 845 patients who received transfusions between 1968 and 2012. Measurements......: Observational study design, underascertainment of the outcome, and possible insufficient statistical power. Conclusion: The data provide no evidence for the transmission of neurodegenerative diseases and suggest that if transmission does occur, it is rare. Primary Funding Source: Swedish Research Council...

  15. Bounds on positive interior transmission eigenvalues

    International Nuclear Information System (INIS)

    This paper contains lower bounds on the counting function of the positive eigenvalues of the interior transmission problem when the latter is elliptic. In particular, these bounds justify the existence of an infinite set of interior transmission eigenvalues and provide asymptotic estimates from above on the counting function for the large values of the wave number. They also lead to certain important upper estimates on the first few interior transmission eigenvalues. We consider the classical transmission problem as well as the case when the inhomogeneous medium contains an obstacle. (paper)

  16. Flexible AC transmission system devices: allocation and transmission pricing

    International Nuclear Information System (INIS)

    The transmission of electricity differs from transportation of any typical commodity by some inherent aspects such as: the production needs to match the consumption at the same time; system control is not an easy task; the electricity flows do not usually follow the economic law. The last aspect is normally observed when transmission systems are included in, for instance, an economic dispatch problem. One way to minimize the operational costs caused by an overloaded transmission system is through the installation of Flexible AC Transmission System (FACTS) devices in the system. They are able to change power flows by modifying the network parameters. This paper focuses on the ability of FACTS devices to change the overall costs of the system and their impact on transmission pricing. The allocation and the determination of the FACTS required are also discussed. Some examples using the IEEE-14 system and the Brazilian electrical system of the Southern region are given to illustrate the concepts introduced in this paper. (author)

  17. Optical set-reset latch

    Science.gov (United States)

    Skogen, Erik J.

    2013-01-29

    An optical set-reset (SR) latch is formed from a first electroabsorption modulator (EAM), a second EAM and a waveguide photodetector (PD) which are arranged in an optical and electrical feedback loop which controls the transmission of light through the first EAM to latch the first EAM in a light-transmissive state in response to a Set light input. A second waveguide PD controls the transmission of light through the second EAM and is used to switch the first EAM to a light-absorptive state in response to a Reset light input provided to the second waveguide PD. The optical SR latch, which may be formed on a III-V compound semiconductor substrate (e.g. an InP or a GaAs substrate) as a photonic integrated circuit (PIC), stores a bit of optical information and has an optical output for the logic state of that bit of information.

  18. Simulated Benefits of Green Infrastructure for Urban Stormwater Management under Climate Change in Different Hydroclimatic and Archetypal Urban Settings [Abstract 2015

    Science.gov (United States)

    Climate change could significantly alter the occurrence and management of urban stormwater runoff quantity and quality. Responding to this challenge requires an improved understanding of potential changes together with the effectiveness of management responses for reducing impact...

  19. A transmission line bridge for the diagnostics of plasma channels

    Science.gov (United States)

    Pechacek, R. E.; Raleigh, M.; Greig, J. R.; Dwyer, T.; Ehrlich, J.

    1984-03-01

    This paper describes a device for measuring the average electrical conductivity of a long, narrow, cylindrical plasma. Interest in plasmas of this shape originates from two areas of study: the study of electron beam propagation through neutral gas, and the study of long straight electrical discharges for use as a communication antenna. Propagation of an electron beam through a neutral gas produces an ionized channel whose properties and evolution are very important to the propagation of the beam itself. Long straight electrical discharges are created in a channel that is ionized by a pulsed laser beam focused with a long focal length lens, and the properties of the plasma in this channel are important to the propagation of the electrical discharge along with channel. The properties of these plasmas are inferred from changes in the transmission properties of a transmission line placed close to and parallel to the plasma. In this paper an analysis is made of the relation between the bridge output voltage and the conductivity of the perturbing plasma for the case in which the conductivity is very low. In this case all perturbations on the bridge parameters are small, and linear approximations are appropriate. The usefulness of the bridge, however, extends to plasma well above this low conductivity range, although a different set of approximations may be necessary to make the analysis of the experiment tractable. A transmission line bridge is a device for measuring very small changes in the properties of transmission lines.

  20. The tower of Babel: Different perceptions and controversies on change and status of North Sea fish stocks in multi-stakeholder settings

    NARCIS (Netherlands)

    Verweij, M.C.; Densen, van W.L.T.; Mol, A.P.J.

    2010-01-01

    Fishermen, scientists, national policy makers, and staff of environmental NGOs (ENGOs) hold different perceptions about temporal patterns in fish stocks. Perception differences are problematic in multi-stakeholder settings, because they elicit controversies and unbalanced disputes. These hinder effe

  1. High Intensity Interval Training in a Real World Setting: A Randomized Controlled Feasibility Study in Overweight Inactive Adults, Measuring Change in Maximal Oxygen Uptake

    OpenAIRE

    Helen Lunt; Nick Draper; Marshall, Helen C.; Logan, Florence J.; Hamlin, Michael J.; Shearman, Jeremy P.; Cotter, James D.; Kimber, Nicholas E.; Gavin Blackwell; Frampton, Christopher M. A.

    2014-01-01

    BACKGROUND: In research clinic settings, overweight adults undertaking HIIT (high intensity interval training) improve their fitness as effectively as those undertaking conventional walking programs but can do so within a shorter time spent exercising. We undertook a randomized controlled feasibility (pilot) study aimed at extending HIIT into a real world setting by recruiting overweight/obese, inactive adults into a group based activity program, held in a community park. METHODS: Participant...

  2. Characterizing the transmission dynamics and control of ebola virus disease.

    Directory of Open Access Journals (Sweden)

    Gerardo Chowell

    2015-01-01

    Full Text Available Carefully calibrated transmission models have the potential to guide public health officials on the nature and scale of the interventions required to control epidemics. In the context of the ongoing Ebola virus disease (EVD epidemic in Liberia, Drake and colleagues, in this issue of PLOS Biology, employed an elegant modeling approach to capture the distributions of the number of secondary cases that arise in the community and health care settings in the context of changing population behaviors and increasing hospital capacity. Their findings underscore the role of increasing the rate of safe burials and the fractions of infectious individuals who seek hospitalization together with hospital capacity to achieve epidemic control. However, further modeling efforts of EVD transmission and control in West Africa should utilize the spatial-temporal patterns of spread in the region by incorporating spatial heterogeneity in the transmission process. Detailed datasets are urgently needed to characterize temporal changes in population behaviors, contact networks at different spatial scales, population mobility patterns, adherence to infection control measures in hospital settings, and hospitalization and reporting rates.

  3. Optimal reliability enhancement for multi-state transmission networks with fixed transmission times

    International Nuclear Information System (INIS)

    Multi-state acyclic transmission networks (MATNs) consist of a number of positions in which independent multi-state elements (MEs) capable of receiving and/or sending a signal are allocated. Each network has a root position where the signal source is located, a number of terminal positions that can only receive a signal, and a number of intermediate positions containing MEs that retransmit the received signal to some other positions. The signal propagation is allowed only in direction of the terminal nodes, which avoids cycles in the network. Each ME that is located in a nonterminal node can have different states determined by a set of nodes receiving the signal directly from this ME. The probability of each state is assumed to be known for each ME. The signal transmission process is associated with delays. The system fails if the signal generated at the first position (source) cannot reach the terminal nodes within a specified time. Rapid changes in digital network technology provides increase of transmission speed of communication lines. Replacement of old lines with the new high performance ones can considerably reduce the signal delivery time in MATN. Subject to budget limitations a question arises which lines should be replaced to obtain the desired reliability improvement effect. An algorithm for solving the minimal cost MATN enhancement problem subject to reliability constraint is presented in the paper. The algorithm is based on an extended universal generating function technique used for MATN reliability evaluation and on a genetic algorithm used as an optimization engine

  4. Impact of climate change and man-made irrigation systems on the transmission risk, long-term trend and seasonality of human and animal fascioliasis in Pakistan

    Directory of Open Access Journals (Sweden)

    Kiran Afshan

    2014-05-01

    Full Text Available Large areas of the province of Punjab, Pakistan are endemic for fascioliasis, resulting in high economic losses due to livestock infection but also affecting humans directly. The prevalence in livestock varies pronouncedly in space and time (1-70%. Climatic factors influencing fascioliasis presence and potential spread were analysed based on data from five mete- orological stations during 1990-2010. Variables such as wet days (Mt, water-budget-based system (Wb-bs indices and the normalized difference vegetation index (NDVI, were obtained and correlated with geographical distribution, seasonality patterns and the two-decade evolution of fascioliasis in livestock throughout the province. The combined approach by these three indices proved to furnish a useful tool to analyse the complex epidemiology that includes (i sheep-goats and cattle- buffaloes presenting different immunological responses to fasciolids; (ii overlap of Fasciola hepatica and F. gigantica; (iii co-existence of highlands and lowlands in the area studied; and (iv disease transmission following bi-seasonality with one peak related to natural rainfall and another peak related to man-made irrigation. Results suggest a human infection situa- tion of concern and illustrate how climate and anthropogenic environment modifications influence both geographical dis- tribution and seasonality of fascioliasis risks. Increased fascioliasis risk throughout the Punjab plain and its decrease in the northern highlands of the province became evident during the study period. The high risk in the lowlands is worrying given that Punjab province largely consists of low-altitude, highly irrigated plains. The importance of livestock in this province makes it essential to prioritise adequate control measures. An annual treatment scheme to control the disease is recom- mended to be applied throughout the whole province.

  5. Transmission dose estimation algorithm for tissue deficit

    International Nuclear Information System (INIS)

    Measurement of transmission dose is useful for in vivo dosimetry. In this study, previous algorithm for estimation of transmission dose was modified for use in cases with tissue deficit. The beam data was measured with flat solid phantom in various conditions of tissue deficit. New algorithm for correction of transmission dose for tissue deficit was developed by physical reasoning. The algorithm was tested in experimental settings with irregular contours mimicking breast cancer patients using multiple sheets of solid phantoms. The correction algorithm for tissue deficit could accurately reflect the effect of tissue deficit with errors within ± 1.0% in most situations and within ± 3.0% in experimental settings with irregular contours mimicking breast cancer treatment set-up. Developed algorithm could accurately reflect the effect of tissue deficit and irregularly shaped body contour on transmission dosimetry

  6. Transmission system planning in competitive and restructured environment - case study: part-1

    International Nuclear Information System (INIS)

    In continuation with previous paper, it is obvious that transmission planning in competitive and restructured environment is very important to have an efficient and economical power system / transmission network in changing trends globally. The recommendations give in part of this paper are implemented on a case study. The conclusions drawn by the study done in part clearly gives positive results in favor of transmission system planning in competitive and restructured environment to have open access and on non-discriminatory basis including the features of wheeling transactions and controlled by the regulatory body to monitor the activities of private set up specially from defense point of view and reliability and stability of the system. The results obtained in previous paper are going to be implemented on a study case. Results of application of transmission system planning in competitive and restructured environment is given at the end. (author)

  7. Will the changes proposed to the conceptual framework’s definitions and recognition criteria provide a better basis for the IASB standard setting?

    NARCIS (Netherlands)

    A. Brouwer; M. Hoogendoorn; E. Naarding

    2015-01-01

    In this paper we evaluate the International Accounting Standards Board’s (IASB) efforts, in a discussion paper (DP) of 2013, to develop a new conceptual framework (CF) in the light of its stated ambition to establish a robust and consistent basis for future standard setting, thereby guiding standard

  8. Change in composition of the Anopheles gambiae complex and its possible implications for the transmission of malaria and lymphatic filariasis in north-eastern Tanzania

    Directory of Open Access Journals (Sweden)

    Derua Yahya A

    2012-06-01

    Full Text Available Abstract Background A dramatic decline in the incidence of malaria due to Plasmodium falciparum infection in coastal East Africa has recently been reported to be paralleled (or even preceded by an equally dramatic decline in malaria vector density, despite absence of organized vector control. As part of investigations into possible causes for the change in vector population density, the present study analysed the Anopheles gambiae s.l. sibling species composition in north-eastern Tanzania. Methods The study was in two parts. The first compared current species complex composition in freshly caught An. gambiae s.l. complex from three villages to the composition reported from previous studies carried out 2–4 decades ago in the same villages. The second took advantage of a sample of archived dried An. gambiae s.l. complex specimens collected regularly from a fourth study village since 2005. Both fresh and archived dried specimens were identified to sibling species of the An. gambiae s.l. complex by PCR. The same specimens were moreover examined for Plasmodium falciparum and Wuchereria bancrofti infection by PCR. Results As in earlier studies, An. gambiae s.s., Anopheles merus and Anopheles arabiensis were identified as sibling species found in the area. However, both study parts indicated a marked change in sibling species composition over time. From being by far the most abundant in the past An. gambiae s.s. was now the most rare, whereas An. arabiensis had changed from being the most rare to the most common. P. falciparum infection was rarely detected in the examined specimens (and only in An. arabiensis whereas W. bancrofti infection was prevalent and detected in all three sibling species. Conclusion The study indicates that a major shift in An. gambiae s.l. sibling species composition has taken place in the study area in recent years. Combined with the earlier reported decline in overall malaria vector density, the study suggests that this

  9. Clustering, climate and dengue transmission.

    Science.gov (United States)

    Junxiong, Pang; Yee-Sin, Leo

    2015-06-01

    Dengue is currently the most rapidly spreading vector-borne disease, with an increasing burden over recent decades. Currently, neither a licensed vaccine nor an effective anti-viral therapy is available, and treatment largely remains supportive. Current vector control strategies to prevent and reduce dengue transmission are neither efficient nor sustainable as long-term interventions. Increased globalization and climate change have been reported to influence dengue transmission. In this article, we reviewed the non-climatic and climatic risk factors which facilitate dengue transmission. Sustainable and effective interventions to reduce the increasing threat from dengue would require the integration of these risk factors into current and future prevention strategies, including dengue vaccination, as well as the continuous support and commitment from the political and environmental stakeholders. PMID:25872683

  10. Goal Setting and Hope

    Science.gov (United States)

    Curran, Katie; Reivich, Karen

    2011-01-01

    The science behind the mechanisms and mediators that lead to successful goal accomplishment has been a focus of research since the 1970s. When an individual desires to make a change or accomplish an outcome, research shows that he or she will be more successful if he or she attends to a number of variables that are key in goal setting.…

  11. Change in Health-Related Quality of Life among Pulmonary Tuberculosis Patients at Primary Health Care Settings in South Africa: A Prospective Cohort Study

    OpenAIRE

    Louw, Julia S.; Mabaso, Musawenkosi; PELTZER, Karl

    2016-01-01

    Introduction Pulmonary tuberculosis (TB) remains a major public health challenge in South Africa. However, little attention is paid to the impact of health related quality of life (HRQL) among TB patients at the beginning and at the end of TB treatment. This study assesses factors associated with HRQL among tuberculosis patients in three high risk provinces in South Africa. Methods A prospective cohort study was conducted at primary health care settings. Patients completed the HRQL social fun...

  12. Study on the changes in the East Asian precipitation in the mid-1990s using a high-resolution global downscaled atmospheric data set

    Science.gov (United States)

    Chang, Eun-Chul; Yeh, Sang-Wook; Hong, Song-You; Kim, Jung-Eun; Wu, Renguang; Yoshimura, Kei

    2014-03-01

    A high-resolution global atmospheric data set (DA126) is used to understand the East Asian summer precipitation variability. It is found that a fine resolution of the DA126 precipitation data is able to reveal the detailed structures of the rainfall variability over East Asia and southern China in comparison with global analysis precipitation data sets such as the Climate Prediction Center Merged Analysis of Precipitation (CMAP). The first two empirical orthogonal functions (EOFs) of the DA126 precipitation data over East Asia accurately reflect a decadal shift in rainfall over southern China in the mid-1990s. Furthermore, the first EOF-related precipitation of the DA126 is related to the tropical Pacific sea surface temperature (SST) variability (i.e., El Niño/Southern Oscillation), and the second EOF-related precipitation is associated with the Indian Ocean SST variability. Consequently, the tropical Pacific and the Indian Ocean SSTs have different associations with the East Asian monsoon precipitation variability. However, it is difficult to find such a relationship in the first two EOFs of the CMAP data set over East Asia. Using the DA126 precipitation data set, our further analysis indicates that warming of both the tropical Pacific and the Indian Ocean causes an increase in the rainfall anomaly over southern China after the mid-1990s, which results in a decadal shift in the rainfall anomaly after the mid-1990s. In addition, the first EOF-related precipitation is associated with both the Pacific-Japan-like (PJ-like) pattern and the Eurasian-like pattern. In contrast, the second EOF-related precipitation is only associated with the PJ-like wave trains from the western Pacific to East Asia.

  13. Strongly oscillating singularities for the interior transmission eigenvalue problem

    International Nuclear Information System (INIS)

    In this paper, we investigate a two-dimensional interior transmission eigenvalue problem for an inclusion made of a composite material. We consider configurations where the difference between the parameters of the composite material and those of the background changes sign on the boundary of the inclusion. In a first step, under some assumptions on the parameters, we extend the variational approach of the T-coercivity to prove that the transmission eigenvalues form at most a discrete set. In the process, we also provide localization results. Then, we study what happens when these assumptions are not satisfied. The main idea is that, due to very strong singularities that can occur at the boundary, the problem may lose Fredholmness in the natural H1 framework. Using Kondratiev theory, we propose a new functional framework where the Fredholm property is restored. (paper)

  14. The automotive transmission book

    CERN Document Server

    Fischer, Robert; Jürgens, Gunter; Najork, Rolf; Pollak, Burkhard

    2015-01-01

    This book presents essential information on systems and interactions in automotive transmission technology and outlines the methodologies used to analyze and develop transmission concepts and designs. Functions of and interactions between components and subassemblies of transmissions are introduced, providing a basis for designing transmission systems and for determining their potentials and properties in vehicle-specific applications: passenger cars, trucks, buses, tractors, and motorcycles. With these fundamentals the presentation provides universal resources for both state-of-the-art and future transmission technologies, including systems for electric and hybrid electric vehicles.

  15. Studies on transmission property changes of optical fibers inside an OPGW heated by conducting or discharge currents; OPGW tsuden/hoden kanetsu ni yoru hikari denso tokusei hendo no kento (sodensen kanshi hoho no chosa kenkyu)

    Energy Technology Data Exchange (ETDEWEB)

    Yamashita, I.; Seikai, S.; Takenaka, T. [Kansai Elecatric Power Co. Inc., Osaka (Japan)

    1999-09-30

    Temperature of OPGW's is known to increase due to thunderbolt. Therefore, the measurement of transmission characteristic changes of optical fibers inside the OPGW is seems to be useful method to supervise the electric power sending systems. Candidates for the detectable characteristics are optical loss, Brilloum frequency shift and Raman scattering power because distribution of these changes can be measured by OTDR techniques. In this experiments, those properties are investigated using a high voltage supply system at the Central Research Institute of Electric Power Industry. A test OPGW containing 24 fibers including 22 single-mode and 2 multi-mode fibers is installed with a span length of 20m. In the current conducting test, the OPGW is heated up to 250 degree C through three times conduction of 6kA with each duration time of 600 or 700ms. In the discharge current test, electric charge of 50C(coulomb), 100C and 200C with 20ms duration are applied. The results of the experiments are summarized as follows. The optical loss change is negligible small except for the fiber brake case and the Brilloum frequency shift is not always suitable because the sensitivity is small. The temperature measurement by the Raman scattering observation using the multi-mode fibers is found to have enough sensitivity and accuracy. However, residual problem is to increase the sensitivity of it for single mode fibers. (author)

  16. Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Temperature over China and surrounding regions: Results from the First Set of LUCID Experiments

    Science.gov (United States)

    Xiang, Zheng; Guo, Weidong

    2016-04-01

    The project Land-Use and Climate, Identification of Robust Impacts (LUCID) was designed to address the robustness of biogeophysical impacts of historical land use-land cover change (LULCC). LUCID used seven atmosphere-land models with a common experimental design to explore those impacts of LULCC that are robust and consistent across the climate models. The biogeophysical impacts of LULCC were also compared to the impact of elevated greenhouse gases and resulting changes in sea surface temperatures and sea ice extent (hereafter SST/CO2). Focusing the analysis on China and surrounding regions, the climate models involved in LUCID show, however, significant differences in the magnitude and the seasonal partitioning of the temperature change. The LULCC-induced cooling is directed by decreases in absorbed solar radiation, but its amplitude is 30 to 50% smaller than the one that would be expected from the sole radiative changes. This results from direct impacts on the total turbulent energy flux (related to changes in land-cover properties other than albedo, such as evapotranspiration efficiency or surface roughness) that decreases at all seasons, and thereby induces a relative warming in all models. The magnitude of those processes varies significantly from model to model, resulting on different climate responses to LULCC.

  17. 目标设定:促进糖尿病患者行为改变的方法%Goal Setting: a Strategy for Behavior Change of Patients with Diabetes

    Institute of Scientific and Technical Information of China (English)

    吴辽芳; 周秋红; 田京玉; 袁莉晴; 邓姗

    2011-01-01

    Goal setting, a procedure for translating patients' self-management and behavior change intentions into goals, is a common behavioral intervention and contributes to behavior change. This paper is to introduce the kind of goals, the principle and procedure of goal setting and the effects of goal setting used in diabetes education program. The results show that although goal setting is an effective strategy for behavior change, it is not a routine part of clinical care. Three factors contribute to the problem. First, patient education materials are not usualy designed to facilitate goal setting. Second, health workers are not trained to help patients create goals.Third, health workers lack time. To help patients set and achieve behavioral goals, the corresponding curriculum should be developed and health workers should be trained.%目标设定是将患者的自我管理和行为改变意图转换为目标的过程,是一种常见的、行之有效的行为干预策略.本文介绍了目标的种类、目标设定的原则、方法及利用目标设定的方法进行糖尿病教育的效果,分析了目标设定在实际应用中存在的问题,为以后更好地利用目标设定的方法进行糖尿病教育,从而达到改变患者行为的目的提供了理论依据.

  18. Transmission system planning in competitive and restructured environment: part-1

    International Nuclear Information System (INIS)

    In restructured environment, competitive markets expose transmission planners to new uncertainties. These are handled using a decision analysis approach whose key contribution is quantifying, minimizing risk with least cost effective plans. Power utility worldwide is under the process of disintegration these days. Now, it is the need of time that existing trends should be changed with the new ones in competitive restructured environment to escape from the present situation and enter into a new set up which is more reliable both from service and stability point of view. Traditionally, transmission planning used to be done by a state owned vertically integrated utility. This type of control on utilities is going to be diminished in coming restructured environment. In restructured environment, open access and on non-discriminatory basis clearly explains its importance including the aspects which gives better and more reliable and stable service in addition to future expansion provisions along with the role of private sector, but not affecting the country's security at any cost. A proper regulatory body must check the activities of private set up transmission planners and also it is must be for private sector to act upon the rules provided by the regulatory authority of that country. The are bound to act upon the guidelines provided by that Regulatory Authority. (author)

  19. Mechanisms underlying disease transmission between spatially separated animals

    NARCIS (Netherlands)

    Bunnik, van B.A.D.

    2014-01-01

      Transmission of infections between spatially separated hosts is a common problem, not only during major outbreaks of livestock diseases, but also in many other settings such as the transmission of infectious diseases between plants and crops or in healthcare settings. During the last major e

  20. Modeling the impact of late 20th century stratospheric ozone changes: Sensitivity to different ozone forcing data sets and zonal asymmetry

    Science.gov (United States)

    Davis, S. M.

    2013-12-01

    Stratospheric ozone depletion in the Antarctic has profoundly influenced both stratospheric and tropospheric climate, and models lacking stratospheric ozone depletion poorly reproduce past Southern Hemisphere (SH) circulation change. Several studies have shown evidence that prescribing zonal-mean ozone in models leads to underestimation of SH change, and that the zonal asymmetry in ozone depletion has a large impact on the zonal-mean climate response. In this presentation we will show simulations from the NCAR Whole Atmosphere Community Climate Model (WACCM) forced with prescribed ozone fields to revisit the issue of whether it is possible to accurately reproduce late 20th century SH circulation change. In this presentation, we will demonstrate an enhanced SH circulation response in simulations with prescribed zonal-mean ozone from a new historical database that more accurately captures the depth of ozone depletion than databases previously used in the SPARC and CMIP5 assessments. We then compare this response from a 2D prescribed ozone field to a simulation using a prescribed 3D ozone field, and assess how well these simulations compare to observed changes seen in the Microwave Sounding Unit satellite temperature datasets and reanalysis.

  1. Automatic Transmission Power Flow Matrix Representation

    OpenAIRE

    Öun, Martin

    2014-01-01

    The project has worked with the function and structure of epicyclical automatic transmissions. The goal of the project has been to find a mathematical way of representing the transmissions setup and possible power flows. Furthermore the project has included the generation of all theoretically possible matrix representations of two simple planetary gear sets in MATLAB as the base for a future optimization model. The result of the project is a large quantity of matrix representations of the two...

  2. TRACKING ACCELERATOR SETTINGS

    International Nuclear Information System (INIS)

    Recording setting changes within an accelerator facility provides information that can be used to answer questions about when, why, and how changes were made to some accelerator system. This can be very useful during normal operations, but can also aid with security concerns and in detecting unusual software behavior. The Set History System (SHS) is a new client-server system developed at the Collider-Accelerator Department of Brookhaven National Laboratory to provide these capabilities. The SHS has been operational for over two years and currently stores about IOOK settings per day into a commercial database management system. The SHS system consists of a server written in Java, client tools written in both Java and C++, and a web interface for querying the database of setting changes. The design of the SHS focuses on performance, portability, and a minimal impact on database resources. In this paper, we present an overview of the system design along with benchmark results showing the performance and reliability of the SHS over the last year

  3. Essays in financial transmission rights pricing

    Science.gov (United States)

    Posner, Barry

    This work examines issues in the pricing of financial transmission rights in the PJM market region. The US federal government is advocating the creation of large-scale, not-for-profit regional transmission organizations to increase the efficiency of the transmission of electricity. As a non-profit entity, PJM needs to allocate excess revenues collected as congestion rents, and the participants in the transmission markets need to be able to hedge their exposure to congestion rents. For these purposes, PJM has developed an instrument known as the financial transmission right (FTR). This research, utilizing a new data set assembled by the author, looks at two aspects of the FTR market. The first chapter examines the problem of forecasting congestion in a transmission grid. In the PJM FTR system firms bid in a competitive auction for FTRs that cover a period of one month. The auctions take place in the middle of the previous month; therefore firms have to forecast congestion rents for the period two to six weeks after the auction. The common methods of forecasting congestion are either time-series models or full-information engineering studies. In this research, the author develops a forecasting system that is more economically grounded than a simple time-series model, but requires less information than an engineering model. This method is based upon the arbitrage-cost methodology, whereby congesting is calculated as the difference of two non-observable variables: the transmission price difference that would exist in the total absence of transmission capacity between two nodes, and the ability of the existing transmission to reduced that price difference. If the ability to reduce the price difference is greater than the price difference, then the cost of electricity at each node will be the same, and congestion rent will be zero. If transmission capacity limits are binding on the flow of power, then a price difference persists and congestion rents exist. Three

  4. Essays in financial transmission rights pricing

    Science.gov (United States)

    Posner, Barry

    This work examines issues in the pricing of financial transmission rights in the PJM market region. The US federal government is advocating the creation of large-scale, not-for-profit regional transmission organizations to increase the efficiency of the transmission of electricity. As a non-profit entity, PJM needs to allocate excess revenues collected as congestion rents, and the participants in the transmission markets need to be able to hedge their exposure to congestion rents. For these purposes, PJM has developed an instrument known as the financial transmission right (FTR). This research, utilizing a new data set assembled by the author, looks at two aspects of the FTR market. The first chapter examines the problem of forecasting congestion in a transmission grid. In the PJM FTR system firms bid in a competitive auction for FTRs that cover a period of one month. The auctions take place in the middle of the previous month; therefore firms have to forecast congestion rents for the period two to six weeks after the auction. The common methods of forecasting congestion are either time-series models or full-information engineering studies. In this research, the author develops a forecasting system that is more economically grounded than a simple time-series model, but requires less information than an engineering model. This method is based upon the arbitrage-cost methodology, whereby congesting is calculated as the difference of two non-observable variables: the transmission price difference that would exist in the total absence of transmission capacity between two nodes, and the ability of the existing transmission to reduced that price difference. If the ability to reduce the price difference is greater than the price difference, then the cost of electricity at each node will be the same, and congestion rent will be zero. If transmission capacity limits are binding on the flow of power, then a price difference persists and congestion rents exist. Three

  5. The emissions reduction commitments set out by the U.S. and China are welcome steps towards avoiding dangerous climate change

    OpenAIRE

    Ward, Bob

    2014-01-01

    On 12 November President Obama and China’s President Xi Jinping announced a commitment that the two countries would reduce their greenhouse gas emissions beyond what had been previously promised. Bob Ward looks at the agreement, writing that while it bodes well for next year’s Paris climate change summit, stronger commitments will be needed for emissions to stay below the warming limit.

  6. Resistive and reactive changes to the impedance of intracortical microelectrodes can be mitigated with polyethylene glycol under acute in vitro and in vivo settings

    OpenAIRE

    Salah eSommakia; Janak eGaire; Rickus, Jenna L.; Otto, Kevin J.

    2014-01-01

    The reactive response of brain tissue to implantable intracortical microelectrodes is thought to negatively affect their recordable signal quality and impedance, resulting in unreliable longitudinal performance. The relationship between the progression of the reactive tissue into a glial scar and the decline in device performance is unclear. We show that exposure to a model protein solution in vitro and acute implantation result in both resistive and capacitive changes to electrode impedance,...

  7. On the setting change of scaling factors for the homogeneous solidified wastes from Tsuruga Plant I of Japan Atomic Power Company

    International Nuclear Information System (INIS)

    Following a request from business operator for confirmation of the generated wastes and their point of view, necessary observation data and required information, JNES (Japan Nuclear Energy Safety Organization) examined the adaptability to the guidelines and regulations of the proposal for changing the scaling factors of Strontium 90 in the homogeneous solidified wastes (concentrated effluent solidified with asphalt) generated from Tsuruga Plant I during 2004-2005. The availability of the proposal is agreed in this report. (S. Ohno)

  8. Changes in the ground water regime on the right side of the Danube after setting Gabcikovo hydro power structures into operation

    International Nuclear Information System (INIS)

    A differentiated decrease of the ground water level occurred on the right-hand side of the Danube, during the long-lasting low water levels in the Danube before damming. The ground water flow from the inland agglomeration of Petrzalka and the Austrian territory enabled the transport of contaminants towards the wells of Waterworks Rusovce - Ostrovne lucky -Mokrad. The rise of the water level in the Cunovo Reservoir has constituted a radical change in the ground water level and flow. On the right hand side of the Danube, the ground water level in the area of the works has increased by approximately 2 - 4 m. The increase of ground water level has had a positive impact on the discharge of the waterworks wells. At present, the prevailing direction of the ground flow is from the Danube towards the water supply well field at Rusovce, and further inland. Since the total dissolved solids in the ground water were originally very high, even up to 1000 mg/l at some localities, a decrease is regarded as a dominant and positive change in the area. The content of chlorides and sulphates, and the total dissolved solids, rapidly decrease at the wells, which were directly affected by the water from urbanized territory before damming. Concerning microbiological parameters the water level raised in the Danube has not caused any extraordinary changes in the wells. Concentrations of all metal microelements is far under the standard limits for drinking water. Therefore, a very positive change with respect to ground water quality, linked with the increase of the proportion of the water infiltrated from the Danube, has been observed. New conditions constitute, from both quantitative and qualitative points of view, an unambiguous profit. (authors). 3 figs., 2 maps, 5 refs

  9. How the Second Delta Committee Set the Agenda for Climate Adaptation Policy: A Dutch Case Study on Framing Strategies for Policy Change

    OpenAIRE

    Simon H. Verduijn; Sander V. Meijerink; Pieter Leroy

    2012-01-01

    In 2008, the Second State Delta Committee, commissioned by the Dutch Secretary of Public Works and Water Management, provided suggestions on how to defend the Netherlands against the expected impacts of climate change, such as sea level rise, longer periods of drought, more intense periods of rainfall and additional land subsidence over the coming two hundred years (Veerman, 2008). In this paper we show that even though no crisis actually occurred, the Second Delta Committee succeeded in thre...

  10. Hydrostatic transmission design

    OpenAIRE

    Dalda Rivas, Ignacio

    2009-01-01

    This project treats the analysis of the hydrostatic transmission dynamic properties using a simulation model, which has been done with the simulation program AMESim. That simulation has been the main work in the project, especially because it is a good way to understand how a hydrostatic transmission works. The hydrostatic transmission are used in heavy vehicles such as earth moving machines, agriculture machines, forest machines, industrial and mining lifters. Nowadays, the demand of that...

  11. ClimateQUAL® and Thinklets: Using ClimateQUAL® with Group Support Systems to Facilitate Discussion and Set Priorities for Organizational Change at Criss Library

    Directory of Open Access Journals (Sweden)

    Nora Hillyer

    2013-06-01

    Full Text Available Objective – This article discusses a series of actions taken by the Criss Library at the University of Nebraska at Omaha to implement organizational change, using the ClimateQUAL® survey and facilitated discussions with ThinkTank™ group decision software. The library had experienced significant changes over a five-year period, with a renovation of the facility and three reorganizations resulting in a 50% staff turnover. Recognizing the strain that years of construction and personnel changes had placed on the organization, there was a desire to uncover the mood of the employees and reveal the issues behind low morale, uneasiness, and fear.Methods – In November 2009, the library conducted a ClimateQUAL® survey to develop a baseline to assess the effectiveness of any changes. After the results were distributed to library faculty and staff, a series of two-hour facilitated discussions was held to gather opinions and ideas for solutions using thinkLets, a pattern language for reasoning toward a goal. The group support system ThinkTank™ software was loaded onto computers, and employees were able to add their ideas anonymously during the sessions. Finally, 12 employees (29% completed a four-question survey on their perceptions of the facilitated discussions.Results – The facilitated discussions returned 76 sub-themes in 12 categories: staffing and scheduling issues, staff unity/teamwork, communication, goodwill/morale, accountability, decision-making, policy issues, skills and training, leadership, ergonomics/physical work environment, respect, and bullying. An advisory team culled the 76 sub-themes into 40 improvement strategies. Five were implemented immediately, and the remaining 35 were scheduled to be presented to the faculty and staff via an online survey. Participants’ perceptions of the facilitated discussions were mixed. Eighty-three percent of respondents reported that they did not feel safe speaking out about issues, most

  12. Comparison of Hounsfield units by changing in size of physical area and setting size of region of interest by using the CT phantom made with a 3D printer

    Energy Technology Data Exchange (ETDEWEB)

    Seung, Youl Hun [Dept. of Radiological Science, Cheongju University, Cheongju (Korea, Republic of)

    2015-12-15

    In this study, we have observed the change of the Hounsfield (HU) in the alteration of by changing in size of physical area and setting size of region of interest (ROI) at focus on kVp and mAs. Four-channel multi-detector computed tomography was used to get transverse axial scanning images and HU. Three dimensional printer which is type of fused deposition modeling (FDM) was used to produce the Phantom. The structure of the phantom was designed to be a type of cylinder that contains 33 mm, 24 mm, 19 mm, 16 mm, 9 mm size of circle holes that are symmetrically located. It was charged with mixing iodine contrast agent and distilled water in the holes. The images were gained with changing by 90 kVp, 120 kVp, 140 kVp and 50 mAs, 100 mAs, 150 mAs, respectively. The ‘image J’ was used to get the HU measurement of gained images of ROI. As a result, it was confirmed that kVp affects to HU more than mAs. And it is suggested that the smaller size of physical area, the more decreasing HU even in material of a uniform density and the smaller setting size of ROI, the more increasing HU. Therefore, it is reason that to set maximum ROI within 5 HU is the best way to minimize in the alteration of by changing in size of physical area and setting size of region of interest.

  13. From Sets to Quarks

    CERN Document Server

    Smith, F T

    1997-01-01

    From sets and simple operations on sets, a Feynman Checkerboard physics model is constructed that allows computation of force strength constants and constituent mass ratios of elementary particles, giving a tree level constituent Truth Quark (top quark) mass of roughly 130 GeV, which is (in my opinion) supported by dileptonic events and some semileptonic events. See http://galaxy.cau.edu/tsmith/HDFCmodel.html and http://www.innerx.net/personal/tsmith/HDFCmodel.html This model is similar to a Lie algebra D4-D5-E6 model: Chapter 1 - Introduction. Chapter 2 - From Sets to Clifford Algebras. Chapter 3 - Octonions and E8 lattices. Chapter 4 - E8 spacetime and particles. Chapter 5 - HyperDiamond Lattices. Chapter 6 - Internal Symmetry Space. Chapter 7 - Feynman Checkerboards. Chapter 8 - Charge = Amplitude to Emit Gauge Boson. Chapter 9 - Mass = Amplitude to Change Direction. Chapter 10 - Protons, Pions, and Physical Gravitons.

  14. Transmission system planning in Ontario

    Energy Technology Data Exchange (ETDEWEB)

    Barrie, D.; Macedo, F.X.; Mcconnach, J.S. [Ontario Hydro, Toronto, ON (Canada)

    1994-12-31

    In recent years, new and modified approaches to planning the large transmission system that serves the province of Ontario, Canada, have been necessary to accommodate the rapidly changing planning environment including slower uncertain growth, ageing of facilities, integration of demand side management and non utility generation options, increased competitiveness, increased financial stresses and affordable constraints. This paper describes some of the new and modified approaches and tools that have been adopted or are being developed by Ontario Hydro to cope with this changing environment. (author) 9 refs., 4 figs.

  15. Control of schistosomiasis transmission

    Directory of Open Access Journals (Sweden)

    Luiz C. de S. Dias

    1995-04-01

    Full Text Available Despite the success of control programmes, schistosomiasis is still a serious public health problem in the world. More than 70 countries where 200 million individuals are evaluated to be infected of a total 600 million at risk. Though there have been important local success in the control of transmission, globally the infection has increased. Economic constrains in developing countries, environmental changes associated with migration and water resources development have been blocking the progress. The main objective of schistosomiasis control is to achieve reduction of disease due to schistosomiasis. We discussed the control measures like: health education, diagnosis and chemotherapy, safe water supplies, sanitation and snail control. We emphasized the need to give priority to school-age children and the importance of integrating the measures of control into locally available systems of health care. The control of schistosomiasis is directly related to the capacity of the preventive health services of an endemic country. The strategy of control requires long-term commitment from the international to the local level.

  16. Independent set dominating sets in bipartite graphs

    Directory of Open Access Journals (Sweden)

    Bohdan Zelinka

    2005-01-01

    Full Text Available The paper continues the study of independent set dominating sets in graphs which was started by E. Sampathkumar. A subset \\(D\\ of the vertex set \\(V(G\\ of a graph \\(G\\ is called a set dominating set (shortly sd-set in \\(G\\, if for each set \\(X \\subseteq V(G-D\\ there exists a set \\(Y \\subseteq D\\ such that the subgraph \\(\\langle X \\cup Y\\rangle\\ of \\(G\\ induced by \\(X \\cup Y\\ is connected. The minimum number of vertices of an sd-set in \\(G\\ is called the set domination number \\(\\gamma_s(G\\ of \\(G\\. An sd-set \\(D\\ in \\(G\\ such that \\(|D|=\\gamma_s(G\\ is called a \\(\\gamma_s\\-set in \\(G\\. In this paper we study sd-sets in bipartite graphs which are simultaneously independent. We apply the theory of hypergraphs.

  17. 78 FR 36182 - APL SouthTex Transmission Company LP, Formerly TEAK Texana Transmission Company, LP; Notice of...

    Science.gov (United States)

    2013-06-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission APL SouthTex Transmission Company LP, Formerly TEAK Texana Transmission... SouthTex) filed to notify the Commission of its name change from TEAK Texana Transmission Company,...

  18. Finite-difference interblock transmissivity for unconfined aquifers and for aquifers having smoothly varying transmissivity

    Science.gov (United States)

    Goode, D.J.; Appel, C.A.

    1992-01-01

    More accurate alternatives to the widely used harmonic mean interblock transmissivity are proposed for block-centered finite-difference models of ground-water flow in unconfined aquifers and in aquifers having smoothly varying transmissivity. The harmonic mean is the exact interblock transmissivity for steady-state one-dimensional flow with no recharge if the transmissivity is assumed to be spatially uniform over each finite-difference block, changing abruptly at the block interface. However, the harmonic mean may be inferior to other means if transmissivity varies in a continuous or smooth manner between nodes. Alternative interblock transmissivity functions are analytically derived for the case of steady-state one-dimensional flow with no recharge. The second author has previously derived the exact interblock transmissivity, the logarithmic mean, for one-dimensional flow when transmissivity is a linear function of distance in the direction of flow. We show that the logarithmic mean transmissivity is also exact for uniform flow parallel to the direction of changing transmissivity in a two- or three-dimensional model, regardless of grid orientation relative to the flow vector. For the case of horizontal flow in a homogeneous unconfined or water-table aquifer with a horizontal bottom and with areally distributed recharge, the exact interblock transmissivity is the unweighted arithmetic mean of transmissivity at the nodes. This mean also exhibits no grid-orientation effect for unidirectional flow in a two-dimensional model. For horizontal flow in an unconfined aquifer with no recharge where hydraulic conductivity is a linear function of distance in the direction of flow the exact interblock transmissivity is the product of the arithmetic mean saturated thickness and the logarithmic mean hydraulic conductivity. For several hypothetical two- and three-dimensional cases with smoothly varying transmissivity or hydraulic conductivity, the harmonic mean is shown to yield

  19. Data Transmission Concepts.

    Science.gov (United States)

    Christenson, Chris

    1995-01-01

    Introduces some basic concepts related to the transmission of data from a computer to its peripherals to help distance educators make decisions regarding computer equipment purchases for their institutions. The following data transmission concepts are described: cables, serial and parallel, synchronous and asynchronous, bandwidth, and analog and…

  20. Study of Stress Sources and Critical Stress Combinations for the Input Shaft of a Longitudinally Mounted Four Speed Automotive Automatic Transmission Model

    OpenAIRE

    N A Abdel-halim

    2013-01-01

    In the present paper; two models of the input shaft for a Longitudinal Mounted four Speed Automotive Automatic Transmission for the first time were introduced to describe the input shaft critical loads. In the first model; the DC (Direct Clutch) connects two gears together. This gives no change in the set torque (the set output torque equal to the set input torque). In the second model; the ODB (Over Drive Brake) fixes one element of the planetary set. This is resulting, the gear set gives r...

  1. Nonlinear magnetoinductive transmission lines

    CERN Document Server

    Lazarides, Nikos; Tsironis, G P

    2011-01-01

    Power transmission in one-dimensional nonlinear magnetic metamaterials driven at one end is investigated numerically and analytically in a wide frequency range. The nonlinear magnetic metamaterials are composed of varactor-loaded split-ring resonators which are coupled magnetically through their mutual inductances, forming thus a magnetoiductive transmission line. In the linear limit, significant power transmission along the array only appears for frequencies inside the linear magnetoinductive wave band. We present analytical, closed form solutions for the magnetoinductive waves transmitting the power in this regime, and their discrete frequency dispersion. When nonlinearity is important, more frequency bands with significant power transmission along the array may appear. In the equivalent circuit picture, the nonlinear magnetoiductive transmission line driven at one end by a relatively weak electromotive force, can be modeled by coupled resistive-inductive-capacitive (RLC) circuits with voltage-dependent cap...

  2. Joint HVAC transmission EMF environmental study

    Energy Technology Data Exchange (ETDEWEB)

    Stormshak, F.; Thompson, J. (Oregon State Univ., Corvallis, OR (United States))

    1992-05-01

    This document describes the rationale, procedures, and results of a carefully controlled study conducted to establish whether chronic exposure of female (ewe) Suffolk lambs to the environment of a 500-kV 60-Hz transmission line would affect various characteristics of growth, endocrine function, and reproductive development. This experiment used identical housing and management schemes for control and line-exposed ewes, thus minimizing these factors as contributors to between-group experimental error. Further, throughout the 10-month duration of this study, changes in electric and magnetic fields, audible noise, and weather conditions were monitored continuously by a computerized system. Such measurements provided the opportunity to identify any relationship between environmental factors and biological responses. Because of reports in the literature that electric and magnetic fields alter concentrations of melatonin in laboratory animals, the primary objective of this study was to ascertain whether a similar effect occurs in lambs exposed to a 500-kV a-c line in a natural setting. In addition, onset of puberty, changes in body weight, wool growth, and behavior were monitored. To determine whether the environment of a 500-kV line caused stress in the study animals, serum levels of cortisol were measured. The study was conducted at Bonneville Power Administration's Ostrander Substation near Estacada, Oregon.

  3. Full circuit calculation for electromagnetic pulse transmission in a high current facility

    Science.gov (United States)

    Zou, Wenkang; Guo, Fan; Chen, Lin; Song, Shengyi; Wang, Meng; Xie, Weiping; Deng, Jianjun

    2014-11-01

    We describe herein for the first time a full circuit model for electromagnetic pulse transmission in the Primary Test Stand (PTS)—the first TW class pulsed power driver in China. The PTS is designed to generate 8-10 MA current into a z -pinch load in nearly 90 ns rise time for inertial confinement fusion and other high energy density physics research. The PTS facility has four conical magnetic insulation transmission lines, in which electron current loss exists during the establishment of magnetic insulation. At the same time, equivalent resistance of switches and equivalent inductance of pinch changes with time. However, none of these models are included in a commercially developed circuit code so far. Therefore, in order to characterize the electromagnetic transmission process in the PTS, a full circuit model, in which switch resistance, magnetic insulation transmission line current loss and a time-dependent load can be taken into account, was developed. Circuit topology and an equivalent circuit model of the facility were introduced. Pulse transmission calculation of shot 0057 was demonstrated with the corresponding code FAST (full-circuit analysis and simulation tool) by setting controllable parameters the same as in the experiment. Preliminary full circuit simulation results for electromagnetic pulse transmission to the load are presented. Although divergences exist between calculated and experimentally obtained waveforms before the vacuum section, consistency with load current is satisfactory, especially at the rising edge.

  4. Have splenectomy rate and main outcomes of ITP changed after the introduction of new treatments? A monocentric study in the outpatient setting during 35 years.

    Science.gov (United States)

    Palandri, Francesca; Polverelli, Nicola; Sollazzo, Daria; Romano, Marco; Catani, Lucia; Cavo, Michele; Vianelli, Nicola

    2016-06-01

    In the last years, rituximab (RTX) and agonists of the thrombopoietin receptor (TPO-R) eltrombopag and romiplostim have provided new treatment options in persistent and chronic immune thrombocytopenia (ITP). Here, we analyzed the changes in therapeutic choices over time and their impact on clinical outcomes in a cohort of 557 ITP outpatients followed at the "L. and A. Seràgnoli" Institute of Hematology, Bologna, Italy, from 1980 to 2015. Overall 397 patients (71%) required front-line corticosteroids, mainly prednisone. Over the decades, splenectomy was delayed from second to third-line, but was steadily used in around 15-25% of patients refractory or relapsing after first-line treatment. Consensually, RTX and TPO-R agonists emerged as second and third-line therapy of choice, respectively. Splenectomy was associated with the best response rates and the lower incidences of relapse, while the relapse rate after RTX was comparable to that observed with corticosteroids and other immunosuppressive agents. The introduction of TPO-R agonists gave an alternative to the administration of immunosuppressive drugs and probably contributed to moderate the incidence of infectious complications that remained stable over the decades, despite an increasing use of RTX from the 2000s onwards. Overall responses were similar over time, with over 97% achieving a response in all time-periods. However, the cumulative risk of bleeding significantly decreased [14.3% (1980-89) vs. 7% (1990-99) vs. 5.6% (2000-09) vs. 0.2% (2010-15)] (P < 0.001), mainly thanks to the optimization of front-line corticosteroids therapy and to the wider availability of second and third-line therapies. Am. J. Hematol. 91:E267-E272, 2016. © 2016 Wiley Periodicals, Inc. PMID:26799593

  5. Determination of set-membership identifiability sets

    OpenAIRE

    Ravanbod-Hosseini, Laleh; Verdière, Nathalie; Jauberthie, Carine

    2014-01-01

    This paper concerns the concept of set-membership identifiability introduced in \\cite{jauberthie}. Given a model, a set-membership identifiable set is a connected set in the parameter domain of the model such that its corresponding trajectories are distinct to trajectories arising from its complementary. For obtaining the so-called set-membership identifiable sets, we propose an algorithm based on interval analysis tools. The proposed algorithm is decomposed into three parts namely {\\it minci...

  6. The interior transmission spectrum in one dimension

    International Nuclear Information System (INIS)

    This paper seeks conditions on acoustic profiles c(x) and b(x) which imply the existence of intervals free of transmission eigenvalues. The existence of intervals free of transmission eigenvalues has important implications in the question of unique recovery of the acoustic profile for inverse acoustic scattering theory using the linear sampling method and for the inverse source problem in thermoacoustic tomography. We examine the interior transmission spectrum relative to two acoustic profiles on the unit interval. This research includes the case when the difference of the two acoustic profiles changes sign and is, to the author's knowledge, the only work to date on the interior transmission spectrum allowing this behavior. It is shown that for a large class of acoustic profiles the transmission spectrum is asymptotically sparse. The spectrum exhibits three distinct types of behavior dependent on the relation of the two acoustic profiles. Numerical examples of each type of behavior are given which show how the transmission eigenvalues are distributed depending on the relation between c(x) and b(x). Our method of study is to reduce the interior transmission problem on [0, 1] to a problem of finding roots of a determinant of fundamental solutions to a Sturm–Liouville problem. The asymptotic expansion of solutions of the Sturm–Liouville problem then allows us to analyze properties of the transmission spectrum for large values of the wavenumber. (paper)

  7. Dengue transmission based on urban environmental gradients in different cities of Pakistan

    Science.gov (United States)

    Khalid, Bushra; Ghaffar, Abdul

    2015-03-01

    This study focuses on the dengue transmission in different regions of Pakistan. For this purpose, the data of dengue cases for 2009-2012 from four different cities (Rawalpindi, Islamabad, Lahore, and Karachi) of the country is collected, evaluated, and compiled. To identify the reasons and regions of higher risk of Dengue transmission, land use classification, analysis of climate covariates and drainage patterns was done. Analysis involves processing of SPOT 5 10 m, Landsat TM 30 m data sets, and SRTM 90 m digital elevation models by using remote sensing and GIS techniques. The results are based on the change in urbanization and population density, analysis of temperature, rainfall, and wind speed; calculation of drainage patterns including stream features, flow accumulation, and drainage density of the study areas. Results suggest that the low elevation areas with calm winds and minimum temperatures higher than the normal, rapid increase in unplanned urbanization, low flow accumulation, and higher drainage density areas favor the dengue transmission.

  8. Interior transmission eigenvalue problem for Maxwell's equations: the T-coercivity as an alternative approach

    International Nuclear Information System (INIS)

    In this paper, we examine the interior transmission problem for Maxwell’s equations in the case where both ε and μ, the physical parameters of the scattering medium, differ from ε0 and μ0 modelling the background medium. Using the T-coercivity method, we propose an alternative approach to the classical techniques to prove that this problem is of Fredholm type and that the so-called transmission eigenvalues form at most a discrete set. The T-coercivity approach allows us to deal with cases where ε − ε0 and μ − μ0 can change sign. We also provide results of localization and Faber–Krahn-type inequalities for the transmission eigenvalues. (paper)

  9. 4th International Conference on Power Transmissions

    CERN Document Server

    2013-01-01

    This books contains the Proceedings of the 4th International Conference on Power Transmissions, that was held in Sinaia, Romania from June 20 -23, 2012. Power Transmissions is a very complex and multi-disciplinary scientific field of Mechanical Engineering that covers the different types of transmissions (mechanical, hydraulic, pneumatic) as well as all the machine elements involved, such as gears, bearings, shafts, couplings and a lot more. It concerns not only their basic theory but also their design, analysis, testing, application and maintenance. The requirements set to modern power transmissions are really tough to meet: They need to be more efficient, stronger, smaller, noiseless, easier to produce and to cost less. There is a strong demand to become easier in operation and maintenance, or even automatic and in maintenance-free. Last but not least, they should be easily recycled and respect the environment. Joint efforts of specialists from both academia and industry can significantly contribute to fulf...

  10. Understanding the transmission access and wheeling problem

    Energy Technology Data Exchange (ETDEWEB)

    Casazza, J.A.

    1985-10-31

    Institutional and regulatory changes in the uses of the nation's bulk power transmission systems that fail to recognize the technical complexity of the systems and the planning and operating problems involved can be disruptive of system reliability and of economic incentive needed for new facilities and technology. This article reviews basic technical and economic considerations connected with the transmission access problem. 2 figures.

  11. The transmission of African culture to children

    OpenAIRE

    Michele Tanon Lora

    2014-01-01

    African ancient traditions suffered a major historical change as a result of colonization. Several decades after decolonization and access to independence, what is the situation and place of the African culture in Africa and outside Africa? Does African culture perpetuate effectively today? What are the obstacles to the transmission of African culture to our children? What are the beliefs or elements that have influenced the transmission of our culture after the period of independence? Roughl...

  12. Wireless Power Transmission

    Directory of Open Access Journals (Sweden)

    Pragati S. Chawardol

    2014-12-01

    Full Text Available A great concern has been voiced in recent years over the extensive use of energy, the limited supply of resourses, and the pollution of the environment from the use of present energy conversion systems. Electrical power accounts for much of the energy consumed. One of the major issue in power system is the losses occurs during the transmission and distribution of electrical power. As the demand increases day by day, the power generation increases and the power loss is also increased. The major amount of power loss occurs during transmission and distribution. The resistance of the wire used in the electrical grid distribution system causes a loss of 26-30% of the energy generated. This loss implies that our present system of electrical distribution is only 70-74% efficient. The above discussed problem can be solved by choose an alternative option for power transmission which could provide much higher efficiency, low transmission cost and avoid power theft. Wireless power transmission is one of the promising technologies and may be the righteous alternative for efficient power transmission. This paper focuses on the past and future possible advancements in WPT. Also the proposed method and technologies in WPT that will make the loss of energy during transmission and distribution to minimum are discussed. Keyword

  13. Understanding Ebola Virus Transmission

    Directory of Open Access Journals (Sweden)

    Seth Judson

    2015-02-01

    Full Text Available An unprecedented number of Ebola virus infections among healthcare workers and patients have raised questions about our understanding of Ebola virus transmission. Here, we explore different routes of Ebola virus transmission between people, summarizing the known epidemiological and experimental data. From this data, we expose important gaps in Ebola virus research pertinent to outbreak situations. We further propose experiments and methods of data collection that will enable scientists to fill these voids in our knowledge about the transmission of Ebola virus.

  14. Tractor Transmissions. A Teaching Reference.

    Science.gov (United States)

    American Association for Agricultural Engineering and Vocational Agriculture, Athens, GA.

    The manual was developed as a reference for teaching students about transmissions in farm tractors. The manual is divided into five sections: (1) transmission history, (2) gears and bearings in transmission, (3) sliding-gear transmissions, (4) planetary gearing, and (5) glossary. The working principles of the sliding-gear transmission, the most…

  15. Transmissions in vehicles 2010

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    Within the international VDI congress 'Gears in vehicles 2010' of the VDI Wissensforum GmbH (Duesseldorf, Federal Republic of Germany) between 22nd and 23rd June, 2010, in Friedrichshafen (Federal Republic of Germany), the following lectures were held: (1) 8HP70H - The moldhybrid transmission from ZF - Cjallenges and achievements (P. Gutmann); (2) GETRAG boosted range extender - A highly flexible electric powertrain for maximum CO{sub 2} reduction (S. Huepkes); (3) E-Transmission between full-hybrid and E-drive (P. Tenberge); (4) Reducing NO{sub x} and particulate emissions in electrified drivelines (R. Kuberczyk); (5) Simulation aided HEV and EV development: from the component to the whole powertrain (A. Gacometti); (6) Investigations on operating behaviour of the optimized CVT hybrid driveline (B.-R. Hoehn); (7) Customer-oriented dimensioning of electrified drivetrains (M. Eghtessad); (8) Decentralized optimal control strategy for parallel hybrid electric vehicles (A. Frenkel); (9) The new generation 6-speed automatic transmission AF40 (G. Bednarek); (10) Customized mechatronic solutions for integrated transmission control units (M. Wieczorek); (11) The optimal automatic transmission for front-transverse applications - Planetary transmissions or dual clutch transmissions? (G. Gumpoltsberger); (12) The new shift-by-wire gearshift lever for the Audi A8 - Requirements and concept (T. Guttenbergere); (13) The new shift-by-wire gearshift lever for the Audi A8 - Realization (A. Giefer); (14) Fuel-efficient transmissions of the future: Calculation of the efficiency factor for vehicle transmissions (B. Volpert); (15) HT-ACM: A new polymer generation for static and dynamic gearbox sealing solutions (E. Osen); (16) 'Energy efficiency equipped solutions by SKF' for power train applications - A contribution to CO{sub 2} - emission reduction and sustainability (T. Bobke); (17) 6-Ratio planetary shift transmission controlled by 4 external brakes, and design

  16. The Evolution of the Intergalactic Medium Transmission to Redshift Six

    CERN Document Server

    Songaila, A

    2004-01-01

    We have measured the transmission of the Lyman alpha forest produced by neutral hydrogen scattering in the intergalactic medium between redshifts 2 and 6.3 using high signal to noise, high resolution (R > 5000) observations of 50 quasars spread over the redshift range. We use a uniform set of 15 Angstrom intervals covering Lyman alpha, Lyman beta, and Lyman gamma absorption regions to tabulate the forest transmission as a function of redshift. The transmitted fractions show a relatively smooth evolution over the entire range of redshifts, which can be modelled with a smoothly decreasing ionization rate. Previous claims of an abrupt change at a redshift of approximately 6 appear in part to be a consequence of an incorrect conversion of Lyman beta to Lyman alpha optical depths. The tabulated transmissions can be used to calculate the colors of objects with a specified input spectrum as a function of redshift. We calculate the colors of a flat f_nu galaxy with a large intrinsic continuum break, as an important e...

  17. Transmission of Flu (Influenza)

    Science.gov (United States)

    ... Skip Content Marketing Share this: Main Content Area Flu (Influenza) Transmission How Flu Spreads Coughing and Sneezing People with flu can ... not be shared without washing thoroughly first. The Flu Is Contagious You may be able to pass ...

  18. Down hole transmission system

    Science.gov (United States)

    Hall, David R.; Hall, Jr., H. Tracy

    2007-07-24

    A transmission system in a downhole component comprises a data transmission element in both ends of the downhole component. Each data transmission element houses an electrically conducting coil in a MCEI circular trough. The electrically conducting coil comprises at least two generally fractional loops. In the preferred embodiment, the transmission elements are connected by an electrical conductor. Preferably, the electrical conductor is a coaxial cable. Preferably, the MCEI trough comprises ferrite. In the preferred embodiment, the fractional loops are connected by a connecting cable. In one aspect of the present invention, the connecting cable is a pair of twisted wires. In one embodiment the connecting cable is a shielded pair of twisted wires. In another aspect of the present invention, the connecting cable is a coaxial cable. The connecting cable may be disposed outside of the MCEI circular trough.

  19. Gravity wave transmission diagram

    OpenAIRE

    Tomikawa, Y.

    2015-01-01

    A new method of obtaining power spectral distribution of gravity waves as a function of ground-based horizontal phase speed and propagation direction from airglow observations has recently been proposed. To explain gravity wave power spectrum anisotropy, a new gravity wave transmission diagram was developed in this study. Gravity wave transmissivity depends on the existence of critical and turning levels for waves that are determined by background horizontal wind distributio...

  20. Understanding Ebola Virus Transmission

    OpenAIRE

    Seth Judson; Joseph Prescott; Vincent Munster

    2015-01-01

    An unprecedented number of Ebola virus infections among healthcare workers and patients have raised questions about our understanding of Ebola virus transmission. Here, we explore different routes of Ebola virus transmission between people, summarizing the known epidemiological and experimental data. From this data, we expose important gaps in Ebola virus research pertinent to outbreak situations. We further propose experiments and methods of data collection that will enable scientists to fil...

  1. Eliminating Perinatal HIV Transmission

    Centers for Disease Control (CDC) Podcasts

    2012-11-26

    In this podcast, CDC’s Dr. Steve Nesheim discusses perinatal HIV transmission, including the importance of preventing HIV among women, preconception care, and timely HIV testing of the mother. Dr. Nesheim also introduces the revised curriculum Eliminating Perinatal HIV Transmission intended for faculty of OB/GYN and pediatric residents and nurse midwifery students.  Created: 11/26/2012 by Division of HIV/AIDS Prevention.   Date Released: 11/26/2012.

  2. Glutamate Transmission in Addiction

    OpenAIRE

    Kalivas, Peter W.; LaLumiere, Ryan; Knackstedt, Lori; Shen, Haowei

    2008-01-01

    Cortico-striatal glutamate transmission has been implicated in both the initiation and expression of addiction related behaviors, such as locomotor sensitization and drug seeking. While glutamate transmission onto dopamine cells in the ventral tegmental area undergoes transient plasticity important for establishing addiction-related behaviors, glutamatergic plasticity in the nucleus accumbens is critical for the expression of these behaviors. This information points to the value of exploring ...

  3. Gravity wave transmission diagram

    Science.gov (United States)

    Tomikawa, Yoshihiro

    2016-07-01

    A possibility of gravity wave propagation from a source region to the airglow layer around the mesopause has been discussed based on the gravity wave blocking diagram taking into account the critical level filtering alone. This paper proposes a new gravity wave transmission diagram in which both the critical level filtering and turning level reflection of gravity waves are considered. It shows a significantly different distribution of gravity wave transmissivity from the blocking diagram.

  4. National transmission grid study

    Energy Technology Data Exchange (ETDEWEB)

    Abraham, Spencer [USDOE Office of the Secretary of Energy, Washington, DC (United States)

    2003-05-31

    The National Energy Policy Plan directed the U.S. Department of Energy (DOE) to conduct a study to examine the benefits of establishing a national electricity transmission grid and to identify transmission bottlenecks and measures to address them. DOE began by conducting an independent analysis of U.S. electricity markets and identifying transmission system bottlenecks using DOE’s Policy Office Electricity Modeling System (POEMS). DOE’s analysis, presented in Section 2, confirms the central role of the nation’s transmission system in lowering costs to consumers through increased trade. More importantly, DOE’s analysis also confirms the results of previous studies, which show that transmission bottlenecks and related transmission system market practices are adding hundreds of millions of dollars to consumers’ electricity bills each year. A more detailed technical overview of the use of POEMS is provided in Appendix A. DOE led an extensive, open, public input process and heard a wide range of comments and recommendations that have all been considered.1 More than 150 participants registered for three public workshops held in Detroit, MI (September 24, 2001); Atlanta, GA (September 26, 2001); and Phoenix, AZ (September 28, 2001).

  5. No change in viral set point or CD4 cell decline among antiretroviral treatment-naïve, HIV-1-infected individuals enrolled in the Danish HIV Cohort Study in 1995-2010

    DEFF Research Database (Denmark)

    Helleberg, M; Kronborg, Gitte; Larsen, C S; Pedersen, Gitte; Pedersen, C; Obel, Niels; Gerstoft, Jan

    2013-01-01

    OBJECTIVES: Recent studies have reported faster progression of HIV infection than anticipated based on results from earlier studies. The aim of the present study was to examine if the virulence of HIV-1 infection changed in the period 1995-2010 among chronically HIV-infected individuals in Denmark....... METHODS: We included all patients registered in the Danish HIV Cohort Study, who were diagnosed in 1995-2009, had a CD4 count > 100 cells/μL at diagnosis and had at least two CD4 measurements prior to initiation of antiretroviral therapy (ART). Changes in viral set point and rate of CD4 cell decline from...... enrolment until the initiation of ART by calendar year of HIV diagnosis were analysed. Time to first CD4 count...

  6. Electricity transmission pricing and technology

    International Nuclear Information System (INIS)

    The electric utility industry and its stake holders in the United States appear to be at a critical juncture in time. Powerful forces of global proportions are propelling the industry instinctively and in a secular fashion towards restructuring. That the industry will change is a fait accomplii. The nature and timing of the change is still a matter of intense debate, however. Because of the evolution of the industry into its present-day form, i.e. regulated local monopolies in their designated franchise service territories, the relative roles and expectations of various institutions would have to change to conform to the new state in the future. In either encouraging, or allowing this change to happen, society is essentially saying that future societal welfare would be better served by the changed structure contemplated. What that assumption translates into in more direct terms is that creation of future wealth would be better accomplished through redistribution of wealth today. Thoughtful individuals recognize the enormous responsibility placed upon the various entities empowered with jurisdiction over the timing and nature of the structural change. They are trying hard to bring analytical rigor to bear on the debate. One very critical element of this debate on restructuring is the issue of the treatment of transmission. The issue has been variously labeled transmission access, or pricing. Volumes have been written and spoken on this topic. We felt that there was a pressing need to assemble a volume which would serve as a one-stop source for varied viewpoints and comprehensive coverage of the subject, both technical and economic. 58 figs., 23 tabs., 103 refs

  7. HIV Transmission at a Saudi Arabia Hemodialysis Unit

    OpenAIRE

    Mashragi, Faisal; Bernstein, Robert S.; Al-Mazroa, Mohammad; Jaffar A. Al-Tawfiq; Filemban, Sanaa; Assiri, Abdullah; Furukawa, Elaine; Al Hazmi, Mohammad; Alzahrani, Abdullah; Stephens, Gwen; Memish, Ziad A.

    2014-01-01

    Background.  Hemodialysis is associated with increased risk of healthcare-associated infections but considered a low-risk setting for human immunodeficiency virus (HIV) transmission. We investigated 3 hemodialysis unit (HDU) patients with new HIV infections to determine whether transmission was hemodialysis-associated and to correct factors that contributed to transmission. Methods.  Each patient was evaluated for HIV risk factors. Blood samples were tested to determine relatedness of HIV str...

  8. IS PRICE TRANSMISSION SYMMETRIC OVER TRANSNATIONALVALUE CHAINS FOR CODFISH PRODUCTS ?

    OpenAIRE

    Menezes, Rui; Dionísio, Andreia

    2008-01-01

    This paper uses a threshold adjustment methodology to find out whether price transmission over the cod value chain between Norway and Portugal is asymmetric. The basic setting relies on price theory and the relationship between prices in the fish market. Empirical tests of price transmission use a cointegration framework similar to many other non-stationary time series analyses. However, it appears that testing for asymmetric price transmission has not been done so often in the...

  9. 蔬菜批发市场和零售市场价格变化及传导机制研究%Research on Vegetable Price Changes and Transmission Mechanism between Wholesale and Retail Markets

    Institute of Scientific and Technical Information of China (English)

    赵安平; 赵友森; 王川; 王晓东

    2011-01-01

    以北京市场大白菜、黄瓜和菠菜为对象,探究批发与零售市场蔬菜价格传导机制.采用相关系数、变异系数、批零比分析蔬菜批零市场价格的各自变化规律,建立VAR模型,运用Granger因果检验、脉冲响应函数和方差分解等分析批零价格相互关系.得出批零价格相关性强,零售市场价格较批发市场稳定,3种蔬菜批发与零售价格比值均维持在2倍的关系.大白菜批零价格互为Granger因果关系,而黄瓜和菠菜则是从批发到零售价格单向引导.脉冲响应函数和方差分解分析表明,不同蔬菜品种批零市场发挥的作用存在一定差异,但是总体来看批发市场或批发商在批零价格传导中发挥主导作用,是价格变动的中心环节,零售商相对处于弱势地位.在此基础上提出完善市内农产品流通机制.规范批发市场经营,引导零售商在市场竞争中发挥更大作用.%This paper explored the wholesale and retail vegetable prices transmission mechanism, at the base of prices of cabbage, cucumber and spinach in Beijing markets. And using correlation coefficient, coefficient of variation, the ratio of wholesale and retail prices, this paper analyzed the price change rules in both wholesale and retail market, and also explored the relationship between wholesale and retail prices, with the establishment of VAR model, Granger causality test, impulse response functions and variance decomposition.The results demonstratd that when wholesale and retail prices obtain a strong correlation, retail market prices were more stable than those of wholesale, and the ratio relationship of the three kinds of vegetables between wholesale and retail prices maintains at 2 times. The cabbage price of wholesale and retail had Granger causal relationship with each other, while prices of cucumber and spinach were in one-way guide from the wholesale to retail price. Impulse response function and variance decomposition analysis

  10. Nonlinear transmission properties in bacteriorhodopsin-embedded photonic crystal

    Science.gov (United States)

    Okada-Shudo, Yoshiko; Ishihara, Teruya

    2003-11-01

    Transmission spectra and photoinduced transmission change are observed in periodic waveguide which consist of a quartz grating substrate and a thin protein film of bacteriorhodopsin. We propose a scheme to achieve all optical switching using the photoinduced refractive index change of bacteriorhodopsin.

  11. Wireless data signal transmission system

    DEFF Research Database (Denmark)

    2014-01-01

    The present invention relates to a method for providing a radio frequency signal for transmission, a system for providing a radio frequency signal for transmission and a method for wireless data transmission between a transmitter and a receiver.......The present invention relates to a method for providing a radio frequency signal for transmission, a system for providing a radio frequency signal for transmission and a method for wireless data transmission between a transmitter and a receiver....

  12. Effect of the one-child policy on influenza transmission in China: a stochastic transmission model.

    Directory of Open Access Journals (Sweden)

    Fengchen Liu

    Full Text Available BACKGROUND: China's one-child-per-couple policy, introduced in 1979, led to profound demographic changes for nearly a quarter of the world's population. Several decades later, the consequences include decreased fertility rates, population aging, decreased household sizes, changes in family structure, and imbalanced sex ratios. The epidemiology of communicable diseases may have been affected by these changes since the transmission dynamics of infectious diseases depend on demographic characteristics of the population. Of particular interest is influenza because China and Southeast Asia lie at the center of a global transmission network of influenza. Moreover, changes in household structure may affect influenza transmission. Is it possible that the pronounced demographic changes that have occurred in China have affected influenza transmission? METHODS AND FINDINGS: To address this question, we developed a continuous-time, stochastic, individual-based simulation model for influenza transmission. With this model, we simulated 30 years of influenza transmission and compared influenza transmission rates in populations with and without the one-child policy control. We found that the average annual attack rate is reduced by 6.08% (SD 2.21% in the presence of the one-child policy compared to a population in which no demographic changes occurred. There was no discernible difference in the secondary attack rate, -0.15% (SD 1.85%, between the populations with and without a one-child policy. We also forecasted influenza transmission over a ten-year time period in a population with a two-child policy under a hypothesis that a two-child-per-couple policy will be carried out in 2015, and found a negligible difference in the average annual attack rate compared to the population with the one-child policy. CONCLUSIONS: This study found that the average annual attack rate is slightly lowered in a population with a one-child policy, which may have resulted from a

  13. Theory of direct sunlight transmission through orthogonal screen cells

    International Nuclear Information System (INIS)

    The Purpose of this paper is to investigate the feasibility of using the Rawshan screens to control high light intensity and to avoid excessive solar radiation penetrating inside the building interior. The exploration of the environmental characteristics of this device indicates an ideal solution to utilize available daylight in the arid atmosphere, reduces energy consumption due to the us of artificial light and ensures the continuity of the traditional architecture and the country heritage. A systematic analysis of direct sunlight transmission has been explored using a mathematical approach. The study intends to construct a predictive tool for the architects through which different specifications of the Rawshan screens were identified as far as direct beam of light concerned. The predictive tool was set-up to investigate various parameters of the screen such as the screen configurations, the aperture configurations, the change in orientation and the effect of the sky condition. The analysis of light transmission through the screen were set-up for orthogonal shapes

  14. Transmission planning in a deregulated environment

    DEFF Research Database (Denmark)

    Xu, Zhao

    2006-01-01

    and approaches toward transmission planning should be carefully designed to ensure system reliability as well as meeting the market requirements. A market-oriented approach for transmission planning in a deregulated environment is proposed. Case studies using the IEEE 14-bus system and the Australian......The worldwide trend for the deregulation of the electricity generation and transmission industries has led to dramatic changes in system operation and planning procedures. The optimum approach to transmission-expansion planning in a deregulated environment is an open problem especially when the...... responsibilities of the organisations carrying out the planning work need to be addressed. To date there is a consensus that the system operator and network manager perform the expansion planning work in a centralised way. However, with an increasing input from the electricity market, the objectives, constraints...

  15. 2006 Final Transmission Proposal.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    2005-06-01

    This Record of Decision (ROD) contains the decisions of the Administrator of the Bonneville Power Administration BPABPA with respect to the adoption of transmission and ancillary services rates for the two-year rate period beginning October 1, 2005, and ending September 30, 2007 (fiscal years (FY) 2006-2007)(2006 Final Transmission and Ancillary Services Rate Proposal). These decisions are based on the record compiled in this rate proceeding. The transmission and ancillary services rates adopted in this ROD are the rates proposed as a result of a comprehensive settlement agreement between BPA's Transmission Business Line (BPA-TBL) and a diverse group of transmission customers, including BPA's Power Business Line (BPA-PBL), regional investor-owned utilities, partial and full requirements customers of the BPA-PBL, Direct Services Industrial (DSI) customers, and merchant generators. The decisions in this ROD to adopt the rates and charges proposed by the settlement agreement are not intended to create or imply any factual , legal, procedural or substantive precedent, or to create agreement to any underlying principle or methodology.

  16. Fast neutrons transmission measurement setup at KFUPM

    Energy Technology Data Exchange (ETDEWEB)

    Naqvi, A.A. [King Fahd University of Petroleum and Minerals, Center for Applied Physical Sciences, Dhahran (Saudi Arabia); Rehman Khateeb-ur; Nagadi, M.M.; Kidwai, S. [Kind Fahd University of Petroleum and Minerals, Department of Physics, Dhahran (Saudi Arabia)

    2002-08-01

    A fast neutron transmission based experimental set up has been developed to determine concentration of hydrogen in the bulk sample. The facility has been tested with transmission of 2.8 MeV neutrons through cylindrical samples. NE213 scintillation detector was used to detect transmitted fast neutrons. In preliminary tests of the facility wood and soil samples containing known amount of water were analyzed. Intensity of fast neutrons transmitted through the samples shows linear correlation with water contents of the soil sample. The facility and results of the preliminary tests will be presented. (author)

  17. NONLINEAR DYNAMIC BEHAVIOR OF VISCOELATIC TRANSMISSION BELT

    Institute of Scientific and Technical Information of China (English)

    Li Yinghui; Gao Qing; Jian Kailin; Yin Xuegang

    2003-01-01

    The nonlinear dynamic responses of viscoelastic axially transmission belts are investigated and the Kelvin viscoelastic differential constitutive model is employed to characterize the material property of belts. The generalized equation of motion is obtained for a viscoelatic axially transmission belts with geometric nonlinearity first, and then is reduced to be a set of second-order nonlinear ordinary differential equations by applying Galerkin's method. Finally, the effects of viscosity parameter and elastic parameter and the moving velocity of the belts on the transient responses are investigated by the research of digital simulation.

  18. Aerosol Transmission of Filoviruses

    Directory of Open Access Journals (Sweden)

    Berhanu Mekibib

    2016-05-01

    Full Text Available Filoviruses have become a worldwide public health concern because of their potential for introductions into non-endemic countries through international travel and the international transport of infected animals or animal products. Since it was first identified in 1976, in the Democratic Republic of Congo (formerly Zaire and Sudan, the 2013–2015 western African Ebola virus disease (EVD outbreak is the largest, both by number of cases and geographical extension, and deadliest, recorded so far in medical history. The source of ebolaviruses for human index case(s in most outbreaks is presumptively associated with handling of bush meat or contact with fruit bats. Transmission among humans occurs easily when a person comes in contact with contaminated body fluids of patients, but our understanding of other transmission routes is still fragmentary. This review deals with the controversial issue of aerosol transmission of filoviruses.

  19. Aerosol Transmission of Filoviruses.

    Science.gov (United States)

    Mekibib, Berhanu; Ariën, Kevin K

    2016-01-01

    Filoviruses have become a worldwide public health concern because of their potential for introductions into non-endemic countries through international travel and the international transport of infected animals or animal products. Since it was first identified in 1976, in the Democratic Republic of Congo (formerly Zaire) and Sudan, the 2013-2015 western African Ebola virus disease (EVD) outbreak is the largest, both by number of cases and geographical extension, and deadliest, recorded so far in medical history. The source of ebolaviruses for human index case(s) in most outbreaks is presumptively associated with handling of bush meat or contact with fruit bats. Transmission among humans occurs easily when a person comes in contact with contaminated body fluids of patients, but our understanding of other transmission routes is still fragmentary. This review deals with the controversial issue of aerosol transmission of filoviruses. PMID:27223296

  20. Dynamic lung transmission studies

    International Nuclear Information System (INIS)

    The aim of this study was to develop a non-invasive method for determining regional lungvolumes, which could replace bronchospirometry in routine clinical use. Transmission through the thorax of sup(99m)Tc-gammarays is measured by means of a gamma camera on line with a computer. The technique of measurement and data analysis is described and tested in several series of phantom studies. The results proved to be good: the mean difference with the real volumes was -4%. The error varied between -10% and +1. Transmission studies and bronchospirometry are compared in a group of 11 patients and there proved to be a good correspondence between the results of these methods. It is concluded that transmission experiments can determine the vital capacity of both lungs as a whole as accurately as spirometry and allows the measurement of vital capacity for each lung separately with the same accuracy as bronchospirometry. (Auth.)

  1. Transmission line capital costs

    International Nuclear Information System (INIS)

    The displacement or deferral of conventional AC transmission line installation is a key benefit associated with several technologies being developed with the support of the U.S. Department of Energy's Office of Energy Management (OEM). Previous benefits assessments conducted within OEM have been based on significantly different assumptions for the average cost per mile of AC transmission line. In response to this uncertainty, an investigation of transmission line capital cost data was initiated. The objective of this study was to develop a database for preparing preliminary estimates of transmission line costs. An extensive search of potential data sources identified databases maintained by the Bonneville Power Administration (BPA) and the Western Area Power Administration (WAPA) as superior sources of transmission line cost data. The BPA and WAPA data were adjusted to a common basis and combined together. The composite database covers voltage levels from 13.8 to 765 W, with cost estimates for a given voltage level varying depending on conductor size, tower material type, tower frame type, and number of circuits. Reported transmission line costs vary significantly, even for a given voltage level. This can usually be explained by variation in the design factors noted above and variation in environmental and land (right-of-way) costs, which are extremely site-specific. Cost estimates prepared from the composite database were compared to cost data collected by the Federal Energy Regulatory Commission (FERC) for investor-owned utilities from across the United States. The comparison was hampered because the only design specifications included with the FERC data were voltage level and line length. Working within this limitation, the FERC data were not found to differ significantly from the composite database. Therefore, the composite database was judged to be a reasonable proxy for estimating national average costs

  2. Can the BestGrid Process Improve Stakeholder Involvement in Electricity Transmission Projects?

    Directory of Open Access Journals (Sweden)

    Nadejda Komendantova

    2015-08-01

    Full Text Available The European Union has set ambitious targets for deployment of renewable energy sources to reach goals of climate change mitigation and energy security policies. However, the current state of electricity transmission infrastructure is a major bottleneck for further scaling up of renewable energy in the EU. Several thousands of kilometers of new lines have to be constructed and upgraded to accommodate growing volumes of intermittent renewable electricity. In many countries, construction of electricity transmission projects has been delayed for several years due to concerns of local stakeholders. The innovative BESTGRID approach, reported here, brings together transmission system operators (TSOs and non-governmental organizations (NGOs to discuss and understand the nature of stakeholder concerns. This paper has three objectives: (1 to understand stakeholder concerns about the deployment of electricity transmission grids in four pilot projects according to five guiding principles: need, transparency, engagement, environment, and impacts on human health as well as benefits; (2 to understand how these principles can be addressed to provide a basis for better decision-making outcomes; and (3 to evaluate the BESTGRID process based on feedback received from stakeholders and the level of participation achieved according to the ladder of Arnstein. This paper goes beyond a discussion of “measures to mitigate opposition” to understand how dialogue between TSOs and the public—represented mainly by NGOs and policy-makers—might lead to a better decision-making process and more sustainable electricity transmission infrastructure deployment.

  3. Optimisation of Video-Data Transmission in Telematic System

    OpenAIRE

    Emilia Bubenikova; Peter Holecko; Rastislav Pirnik

    2013-01-01

    The goal of this paper is to analyse, define, and summarise the requirements on networks connecting telematic technologies based on Intelligent Transport Systems (ITS). The paper describes the methodics of setting and a general concept of technological networks interface based on available and applicable standards Focus is set on optimisation of data transmission in the form of a video-stream and its tunnelling through xDSL transmission technology. The implementation of the designed compres...

  4. Optimisation of video-data transmission in telematic system

    OpenAIRE

    Bubeníková, Emília; Pirník, Rastislav; Holečko, Peter

    2013-01-01

    The goal of this paper is to analyse, define, and summarise the requirements on networks connecting telematic technologies based on Intelligent Transport Systems (ITS). The paper describes the methodics of setting and a general concept of technological networks interface based on available and applicable standards Focus is set on optimisation of data transmission in the form of a video-stream and its tunnelling through xDSL transmission technology. The implementation of the designed compressi...

  5. Harmonics in transmission power systems

    DEFF Research Database (Denmark)

    Wiechowski, Wojciech Tomasz

    , provided that background harmonic distortion, and the network configuration, are not changing during the measurement. It is shown that switching of a shunt linear power system component can result in variation of the harmonic levels that can be measured and used to verify the harmonic model of the network......, in order to determine which power system component, when switched, results in the largest change in harmonic levels, some initial harmonic simulations, using the created harmonic model of Energinet.dk transmission network, are performed. The criterion is that the measuring equipment shall not be installed...... of the measurements. The conclusion is that a key requirement of this technique is a good synchronization of the measurements. Capacitive voltage transformers installed at the 400 kV substations are not suited to measure higher frequencies and the capacitive taps of the 400 kV/150 kV autotransformer bushings are used...

  6. Transmission grid security

    CERN Document Server

    Haarla, Liisa; Hirvonen, Ritva; Labeau, Pierre-Etienne

    2011-01-01

    In response to the growing importance of power system security and reliability, ""Transmission Grid Security"" proposes a systematic and probabilistic approach for transmission grid security analysis. The analysis presented uses probabilistic safety assessment (PSA) and takes into account the power system dynamics after severe faults. In the method shown in this book the power system states (stable, not stable, system breakdown, etc.) are connected with the substation reliability model. In this way it is possible to: estimate the system-wide consequences of grid faults; identify a chain of eve

  7. Principal Components Analysis of Triaxial Vibration Data From Helicopter Transmissions

    Science.gov (United States)

    Tumer, Irem Y.; Huff, Edward M.

    2001-01-01

    Research on the nature of the vibration data collected from helicopter transmissions during flight experiments has led to several crucial observations believed to be responsible for the high rates of false alarms and missed detections in aircraft vibration monitoring systems. This work focuses on one such finding, namely, the need to consider additional sources of information about system vibrations. In this light, helicopter transmission vibration data, collected using triaxial accelerometers, were explored in three different directions, analyzed for content, and then combined using Principal Components Analysis (PCA) to analyze changes in directionality. In this paper, the PCA transformation is applied to 176 test conditions/data sets collected from an OH58C helicopter to derive the overall experiment-wide covariance matrix and its principal eigenvectors. The experiment-wide eigenvectors. are then projected onto the individual test conditions to evaluate changes and similarities in their directionality based on the various experimental factors. The paper will present the foundations of the proposed approach, addressing the question of whether experiment-wide eigenvectors accurately model the vibration modes in individual test conditions. The results will further determine the value of using directionality and triaxial accelerometers for vibration monitoring and anomaly detection.

  8. The potential for sexual transmission to compromise control of Ebola virus outbreaks.

    Science.gov (United States)

    Vinson, John E; Drake, John M; Rohani, Pejman; Park, Andrew W

    2016-06-01

    Recent evidence suggests that sexual contact may give rise to transmission of Ebola virus long after infection has been cleared from blood. We develop a simple mathematical model that incorporates contact transmission and sexual transmission parametrized from data relating to the 2013-2015 West African Ebola epidemic. The model explores scenarios where contact transmission is reduced following infection events, capturing behaviour change, and quantifies how these actions reducing transmission may be compromised by sexual transmission in terms of increasing likelihood, size and duration of outbreaks. We characterize the extent to which sexual transmission operates in terms of the probability of initial infection resolving to sexual infectiousness and the sexual transmission rate, and relate these parameters to the overall case burden. We find that sexual transmission can have large effects on epidemic dynamics (increasing attack ratios from 25% in scenarios without sexual transmission but with contact-transmission-reducing behaviour, up to 80% in equivalent scenarios with sexual transmission). PMID:27277951

  9. Gas transmission through microporous membranes

    Science.gov (United States)

    Turel, Tacibaht

    2008-10-01

    An ideal protective clothing material should be a good barrier against harmful gases or vapor while allowing moisture vapor and air passage through the material. In the study and design of barrier materials, one of the critical issues is to balance these requirements, which may sometimes be mutually exclusive. Therefore it is critical to understand the macroscopic and microscopic structure of the attack mechanisms as well as the barrier materials and the transport phenomena in such systems. In this study, air and gas transmission through barrier systems consisting of porous membranes was investigated experimentally and a molecular-level probabilistic model was constructed to evaluate the effect of various parameters on the gas flow. The effect of membrane parameters such as porosity, pore size distribution, thickness as well as gas parameters such as molecule diameters were examined at single layer as well as multiple layers. To understand the gas behavior for harmful chemicals and to ensure safety during experimental studies, mimics of such gases were obtained which were comparable to the actual gases in shape, molecular weight and other chemical properties. Air, ammonia and several mimic gases of harmful chemical agents were studied. Beta-pinene was used as a mimic of sarin and prenol was used as a mimic of nitrogen mustard. Gas transmission experiments were conducted on polyester, nylon and polypropylene membranes each of which had different porosity and pore size distributions. Experiments were done at different pressure values and a comparison was made between permeability testing machines based on volumetric and manometric principles as to their ability to accommodate high permeability membranes. Physical and chemical adsorption of such gases on porous membranes was also investigated after the addition of active elements on the membrane surfaces which can interact with the gas molecules. An experimental setup was developed to measure concentration changes

  10. Viewing transmission issues in perspective

    International Nuclear Information System (INIS)

    This article examines electric power transmission from the perspective of the power producers. The article discusses the impact to transmission line routing policy of the health effects of, and public opinion about, electromagnetic fields. The author examines past pricing policy for transmission access and encourages the power producers and owners of transmission lines to become more involved in the regulatory process

  11. Viewing transmission issues in perspective

    Energy Technology Data Exchange (ETDEWEB)

    Casazza, J.A.

    1993-10-01

    This article examines electric power transmission from the perspective of the power producers. The article discusses the impact to transmission line routing policy of the health effects of, and public opinion about, electromagnetic fields. The author examines past pricing policy for transmission access and encourages the power producers and owners of transmission lines to become more involved in the regulatory process.

  12. Transmission analysis in WDM networks

    DEFF Research Database (Denmark)

    Rasmussen, Christian Jørgen

    1999-01-01

    This thesis describes the development of a computer-based simulator for transmission analysis in optical wavelength division multiplexing networks. A great part of the work concerns fundamental optical network simulator issues. Among these issues are identification of the versatility and user...... the different component models are invoked during the simulation of a system. A simple set of rules which makes it possible to simulate any network architectures is laid down. The modelling of the nonlinear fibre and the optical receiver is also treated. The work on the fibre concerns the numerical solution......-friendliness demands which such a simulator must meet, development of the "spectral window representation" for representation of the optical signals and finding an effective way of handling the optical signals in the computer memory. One important issue more is the rules for the determination of the order in which...

  13. The interior transmission eigenvalue problem for absorbing media

    International Nuclear Information System (INIS)

    In recent years, the transmission eigenvalue problem has been extensively studied for non-absorbing media. In this paper, we initiate the study of this problem for absorbing media. In particular, we show that, in the case of absorbing media, transmission eigenvalues form a discrete set, exist for sufficiently small absorption and for spherically stratified media exist without this assumption. For constant index of refraction, we also obtain regions in the complex plane where the transmission eigenvalues cannot exist and obtain a priori estimates for real transmission eigenvalues. (paper)

  14. Transmission of preferences and beliefs about female labor market participation : direct evidence on the role of mothers

    OpenAIRE

    Mora, Ricardo; Machado, Matilde P.; Carro, Jesús M.

    2014-01-01

    Recently, economists have established that culture—defined as a common set of preferences and beliefs —affects economic outcomes, including the levels of female labor force participation. Although this literature has argued that culture is transmitted from parents to children, it has also recognized the difficulty in empirically disentangling the parental transmission of preferences and/or beliefs from other confounding factors, such as technological change or investment in education. Using c...

  15. Economical quantum anonymous transmissions

    International Nuclear Information System (INIS)

    We present a new information-theoretically secure protocol for the anonymous transmission of quantum information. Different from the pioneering works, we use single photons to construct anonymous entanglement instead of multi-partite entangled states in this protocol, and therefore we reduce the complexity of physical implementation in practice.

  16. Watching Handball Transmissions

    DEFF Research Database (Denmark)

    Frandsen, Kirsten

    2010-01-01

    competent when mastering the game and in relation to others. The study shows that entertainment concerns both affective involvement and identity formation, as social and cultural meaning seem to be at the root of involvement. Even though both men and women find great joy in the transmissions, their viewing...

  17. Improving Transmission Planning

    OpenAIRE

    Saraswat, Kavita; Gupta, Amol

    2016-01-01

    Development of power transmission networks requires long lead times and substantial capital. Optimization of investment is especially critical in fast-growing economies such as India’s, where there are competing demands on financial resources, and utilities need to maintain adequate cash flow to expand electricity service for economic growth and poverty reduction. As shown by examples from...

  18. Dilemmas of Cultural Transmission

    Science.gov (United States)

    Kováts-Németh, Mária

    2016-01-01

    The fundamental problem of the 21st century is that in the modern civilization "the transmission of values is not stable." There is nothing, except for the natural sense of justice and some legal traditions, which would exercise selective power on social behavior. At a critical time in 1949 Albert Szent-Györgyi drew the attention to the…

  19. Neutron transmission and capture of 241Am

    International Nuclear Information System (INIS)

    A set of neutron transmission and capture experiments based on the Time Of Flight (TOF) technique, were performed in order to determine the 241Am capture cross section in the energy range from 0.01 eV to 1 keV. The GELINA facility of the Institute for Reference Materials and Measurements (IRMM) served as the neutron source. A pair of C6D6 liquid scintillators was used to register the prompt gamma rays emerging from the americium sample, while a Li-glass detector was used in the transmission setup. Results from the capture and transmission data acquired are consistent with each other, but appear to be inconsistent with the evaluated data files. Resonance parameters have been derived for the data up to the energy of 100 eV. (authors)

  20. Numerical evaluation of volumetric weighted mean transmissivity estimates in laterally heterogeneous aquifers

    Science.gov (United States)

    Rhode, Katherine L.; Osiensky, James L.; Miller, Stanley M.

    2007-12-01

    SummaryMost previous investigations to evaluate the "effective" or average transmissivity in heterogeneous environments have used calculations based on areas to weight the effects of each heterogeneity. Analysis of spatial volumetric variations within the cone of depression expressed at the potentiometric surface offers a more general solution to evaluate the meaning of transmissivity ( T) and storativity ( S) values derived from aquifer tests in these environments. The [Cooper Jr., H.H., Jacob, C.E. 1946. A generalized graphical method for evaluating formation constants and summarizing well-field history. Eos Trans. AGU, 27(4), 526-534] method is used to demonstrate that T variations reflected in slope changes in plots of the pumping well drawdown data correspond to changes in the volumetric weighted mean transmissivity ( VWMT) over time. Lognormal distributions of transmissivity are represented by block heterogeneities within two simulated aquifers, for both spatially random and spatially correlated data sets. By analyzing the volumetric evolution of the cone of depression observed in the potentiometric surface, the nature of T averaging within the cone of depression as a function of time is illustrated. Volumetric analysis shows that the average aquifer T varies with time as the cone of depression progressively envelops different heterogeneities. The initial trend is controlled primarily by the heterogeneities directly surrounding the pumping center. If steady-shape conditions are not achieved, late-time VWMT values do not approach an asymptotic limit.

  1. Transplacental transmission of Bluetongue virus serotype 1 and serotype 8 in sheep: virological and pathological findings.

    Directory of Open Access Journals (Sweden)

    Mirjam T W van der Sluijs

    Full Text Available The Bluetongue virus serotype 8 (BTV-8 strain, which emerged in Europe in 2006, had an unusually high ability to cause foetal infection in pregnant ruminants. Other serotypes of BTV had already been present in Europe for more than a decade, but transplacental transmission of these strains had never been demonstrated. To determine whether transplacental transmission is a unique feature of BTV-8 we compared the incidence and pathological consequences of transplacental transmission of BTV-8 to that of BTV-1. Nine pregnant ewes were infected with either BTV-8 or BTV-1. The BTV strains used for the infection were field strains isolated on embryonated chicken eggs and passaged twice on mammalian cells. Blood samples were taken to monitor the viraemia in the ewes. Four weeks after the infection, the foetuses were examined for pathological changes and for the presence of BTV. BTV-8 could be demonstrated in 12 foetuses (43% from 5 ewes (56%. %. BTV-1 was detected in 14 foetuses (82% from 6 ewes (67%. Pathological changes were mainly found in the central nervous system. In the BTV-8 group, lympho-histiocytic infiltrates, gliosis and slight vacuolation of the neuropil were found. BTV-1 infection induced a severe necrotizing encephalopathy and severe meningitis, with macroscopic hydranencephaly or porencephaly in 8 foetuses. In our experimental setting, using low passaged virus strains, BTV-1 was able to induce transplacental transmission to a higher incidence compared to BTV-8, causing more severe pathology.

  2. On Bipolar Soft Sets

    OpenAIRE

    Shabir, Muhammad; Naz, Munazza

    2013-01-01

    We have studied the concept of bipolarity of information in the soft sets. We have defined bipolar soft sets and basic operations of union, intersection and complementation for bipolar soft sets. Examples of bipolar soft sets and an application of bipolar soft sets in a decision making problem with general algorithms have also been presented at the end.

  3. Topics on Electricity Transmission Pricing

    International Nuclear Information System (INIS)

    Within the last decade we have experienced deregulation of several industries, such as airlines, telecommunications and the electric utility industry, the last-mentioned being the focus of this work. Both the telecommunications and the electricity sector depend on network facilities, some of which are still considered as natural monopolies. In these industries, open network access is regarded as crucial in order to achieve the gains from increased competition, and transmission tariffs are important in implementing this. Based on the Energy Act that was introduced in 1991, Norway was among the first countries to restructure its electricity sector. On the supply side there are a large number of competing firms, almost exclusively hydro plants, with a combined capacity of about 23000 MW, producing 105-125 TWh per year, depending on the availability of water. Hydro plants are characterized by low variable costs of operation, however since water may be stored in dams, water has an opportunity cost, generally known as the water value, which is the shadow price of water when solving the generator's inter temporal profit maximization problem. Water values are the main factor of the producers' short run marginal cost. Total consumption amounts to 112-117 TWh a year, and consumers, even households, may choose their electricity supplier independent of the local distributor to which the customer is connected. In fact, approximately 10% of the households have actually changed supplier. The web-site www.konkurransetilsynet.no indicates available contracts, and www.dinside.no provides an ''energy-calculator'' where one can check whether it is profitable to switch supplier. If a customer buys energy from a remote supplier, the local distributor only provides transportation facilities for the energy and is compensated accordingly. Transmission and distribution have remained monopolized and regulated by the Norwegian Water Resources and Energy Directorate (NVE). To prevent cross

  4. Oral Transmission: A Marriage of Music, Language, Tradition, and Culture

    OpenAIRE

    Emma E. Patterson

    2015-01-01

    There are a number of misunderstandings about ancient oral transmission that negatively affect the way musicians view music history but also the process of how music was and currently is conceived, recorded, and shared. A common misconception is that oral transmission of music is an ancient practice that occurred before written notation of music was developed. However, I seek to prove that there is a false dichotomy between oral transmission and written notation and I focus on the changing de...

  5. Condition Monitoring Method for Automatic Transmission Clutches

    OpenAIRE

    Agusmian Partogi Ompusunggu; Jean-Michel Papy; Steve Vandenplas; Paul Sas; Hendrik Van Brussel

    2012-01-01

    This paper presents the development of a condition monitoring method for wet friction clutches which might be useful for automatic transmission applications. The method is developed based on quantifying the change of the relative rotational velocity signal measured between the input and output shaft of a clutch. Prior to quantifying the change, the raw velocity signal is preprocessed to capture the relative velocity signal of interest. Three dimensionless parameters, namely the normalized eng...

  6. Climate and Dengue Transmission: Evidence and Implications

    OpenAIRE

    Morin, Cory W.; Comrie, Andrew C.; Ernst, Kacey

    2013-01-01

    Background: Climate influences dengue ecology by affecting vector dynamics, agent development, and mosquito/human interactions. Although these relationships are known, the impact climate change will have on transmission is unclear. Climate-driven statistical and process-based models are being used to refine our knowledge of these relationships and predict the effects of projected climate change on dengue fever occurrence, but results have been inconsistent. Objective: We sought to identify ma...

  7. Regional transmission subsystem planning

    Energy Technology Data Exchange (ETDEWEB)

    Costa Bortoni, Edson da [Quadrante Softwares Especializados Ltda., Itajuba, MG (Brazil); Bajay, Sergio Valdir; Barros Correia, Paulo de [Universidade Estadual de Campinas, SP (Brazil). Faculdade de Engenharia Mecanica; Santos, Afonso Henriques Moreira; Haddad, Jamil [Escola Federal de Engenharia de Itajuba, MG (Brazil)

    1994-12-31

    This work presents an approach for the planning of transmission systems by employing mixed--integer linear programming to obtain a cost and operating characteristics optimized system. The voltage loop equations are written in a modified form, so that, at the end of the analysis, the model behaves as a DC power flow, with the help of the two Kirchhoff`s laws, exempting the need of interaction with an external power flow program for analysis of the line loading. The model considers the occurrence of contingencies, so that the final result is a network robust to the most severe contingencies. This whole technique is adapted to the regional electric power transmission subsystems. (author) 9 refs., 4 figs.

  8. ECRH transmission system

    International Nuclear Information System (INIS)

    The M.I.T. gyrotron group operates a 140 GHz, short pulse (1μs) gyrotron with output power, at present, of up to 175 kW. Output radiation has been obtained in several modes, including TE03 at 140 GHz, TE23 at 137 GHz, TE42 at 128 GHz and TE52 at 145 GHz. Studies have been carried out of the mode purity, both in frequency and in space, of gyrotron output radiation. These studies investigate parasitic mode excitation and mode conversion of gyrotron output power. Far field patterns of gyrotron radiation have been investigated to determine mode symmetry and purity. These results are useful in estimating the efficiency of various transmission systems. Finally, a new approach to quasi-optical transmission lines and mode converters, using axisymmetric optics, is suggested

  9. Data transmission networks

    Science.gov (United States)

    Alexovich, Robert

    1990-01-01

    A task order was written by the High Resolution, High Frame Rate Video Technology (HHVT) project engineers to investigate data compression techniques that could be applied to the HHVT system, and both existing and planned downlink/uplink capabilities of the Space Shuttle and Space Station Freedom. The following tasks were included: (1) Investigate signal channel availability and determine both the maximum possible data rate and the average data rate; (2) Identify time blocks for HHVT video transmission assuming time sharing and interruptions in the communication links; (3) Determine the bit error rates to be expected; and (4) Define the transmit and receive interfaces. A summary chart of the data transmission capabilities for Tracking and Data Relay Satellite System (TDRSS), the Space Shuttle, Space Station Freedom, Spacelab, and USLab are also presented.

  10. Global wireless power transmission

    OpenAIRE

    Glaser, Peter E.

    1995-01-01

    Economic and environmental pressures require the development of technologies that are compatible with the Earth’s environment and acceptable to society. An emerging power supply option based on Nikola Tesla’s concept of wireless power transmission (WPT) can be applied to transmit power over intercontinental distances with power relay satellites (PRS) [1] to access renewable energy sources at undeveloped or underutilized remote sites, and to convert solar energy in space for use on Earth on a ...

  11. Transmission of Helicobacter pylori

    OpenAIRE

    Axon, Anthony T. R.

    1999-01-01

    Helicobacter gastroduodenitis is a serious chronic infectious disease that is responsible for widespread morbidity and mortality. An understanding of the way in which it spreads is fundamentally important when considering measures for its control. Its prevalence is highest in the developing world and in individuals with a disadvantaged socio-economic childhood. The disease is believed to be contracted during the early years of life. A faeco-oral mode of transmission is considered by many to b...

  12. Wireless Power Transmission

    OpenAIRE

    Pragati S. Chawardol; Deepali R. Badre ,; , Mithul S. There

    2014-01-01

    A great concern has been voiced in recent years over the extensive use of energy, the limited supply of resourses, and the pollution of the environment from the use of present energy conversion systems. Electrical power accounts for much of the energy consumed. One of the major issue in power system is the losses occurs during the transmission and distribution of electrical power. As the demand increases day by day, the power generation increases and the power loss is also increas...

  13. Superconductive communication transmission

    International Nuclear Information System (INIS)

    Recent developments in superconducting techniques have made possible the application of superconductivity in communication cables. Extensive studies have been made, and several experimental coaxial lines and superconductive communication cables have been produced and tested. The attenuation and transmission capacities of superconductive coaxial lines are greatly improved compared with existing cables. Furthermore, the cost of superconductive communication cables is far less than that of existing cables. (author)

  14. The effect of electric transmission constraints on how power generation companies bid in the Colombian electrical power market

    Directory of Open Access Journals (Sweden)

    Luis Eduardo Gallego Vega

    2010-06-01

    Full Text Available This paper presents the results of research about the effect of transmission constraints on both expected electrical energy to be dispatched and power generation companies’ bidding strategies in the Colombian electrical power market. The proposed model simulates the national transmission grid and economic dispatch by means of optimal power flows. The proposed methodology allows structural problems in the power market to be analyzed due to the exclusive effect of trans- mission constraints and the mixed effect of bidding strategies and transmission networks. A new set of variables is proposed for quantifying the impact of each generation company on system operating costs and the change in expected dispatched energy. A correlation analysis of these new variables is presented, revealing some interesting linearities in some generation companies’ bidding patterns.

  15. Border Malaria Associated with Multidrug Resistance on Thailand-Myanmar and Thailand-Cambodia Borders: Transmission Dynamic, Vulnerability, and Surveillance

    Directory of Open Access Journals (Sweden)

    Adisak Bhumiratana

    2013-01-01

    Full Text Available This systematic review elaborates the concepts and impacts of border malaria, particularly on the emergence and spread of Plasmodium falciparum and Plasmodium vivax multidrug resistance (MDR malaria on Thailand-Myanmar and Thailand-Cambodia borders. Border malaria encompasses any complex epidemiological settings of forest-related and forest fringe-related malaria, both regularly occurring in certain transmission areas and manifesting a trend of increased incidence in transmission prone areas along these borders, as the result of interconnections of human settlements and movement activities, cross-border population migrations, ecological changes, vector population dynamics, and multidrug resistance. For regional and global perspectives, this review analyzes and synthesizes the rationales pertaining to transmission dynamics and the vulnerabilities of border malaria that constrain surveillance and control of the world’s most MDR falciparum and vivax malaria on these chaotic borders.

  16. Transmission of light through magnetic nanocavities.

    Science.gov (United States)

    Patoka, Piotr; Skeren, Tomas; Hilgendorff, Michael; Zhi, Linjie; Paudel, Trilochan; Kempa, Krzysztof; Giersig, Michael

    2011-11-01

    The transmission of light through a metallic film stack on a transparent substrate, perforated with a periodic array of cylindrical holes/nanocavities, is studied. The structure is fabricated by using self-assembled nanosphere lithography. Since one layer in the film stack is made of a ferromagnetic metal (iron), exposure of the structure to a solution containing iron oxide nanoparticles causes nanoparticle accumulation inside the nanocavities. This changes the dielectric constant inside the nanocavities and thus affects the light transmission. Simulations are in good agreement with experiment, and show large sensitivity of the response to the amount of iron oxide nanoparticles deposited. This could be used in various sensor applications. PMID:21916008

  17. EC Transmission Line Risk Identification and Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Bigelow, Tim S [ORNL

    2012-04-01

    The purpose of this document is to assist in evaluating and planning for the cost, schedule, and technical project risks associated with the delivery and operation of the EC (Electron cyclotron) transmission line system. In general, the major risks that are anticipated to be encountered during the project delivery phase associated with the implementation of the Procurement Arrangement for the EC transmission line system are associated with: (1) Undefined or changing requirements (e.g., functional or regulatory requirements) (2) Underperformance of prototype, first unit, or production components during testing (3) Unavailability of qualified vendors for critical components Technical risks associated with the design and operation of the system are also identified.

  18. Topics in Electricity Transmission Pricing

    Energy Technology Data Exchange (ETDEWEB)

    Bjoerndal, Mette

    2000-02-01

    Within the last decade we have experienced deregulation of several industries, such as airlines, telecommunications and the electric utility industry, the last-mentioned being the focus of this work. Both the telecommunications and the electricity sector depend on network facilities, some of which are still considered as natural monopolies. In these industries, open network access is regarded as crucial in order to achieve the gains from increased competition, and transmission tariffs are important in implementing this. Based on the Energy Act that was introduced in 1991, Norway was among the first countries to restructure its electricity sector. On the supply side there are a large number of competing firms, almost exclusively hydro plants, with a combined capacity of about 23000 MW, producing 105-125 TWh per year, depending on the availability of water. Hydro plants are characterized by low variable costs of operation, however since water may be stored in dams, water has an opportunity cost, generally known as the water value, which is the shadow price of water when solving the generator's inter temporal profit maximization problem. Water values are the main factor of the producers' short run marginal cost. Total consumption amounts to 112-117 TWh a year, and consumers, even households, may choose their electricity supplier independent of the local distributor to which the customer is connected. In fact, approximately 10% of the households have actually changed supplier. The web-site www.konkurransetilsynet.no indicates available contracts, and www.dinside.no provides an ''energy-calculator'' where one can check whether it is profitable to switch supplier. If a customer buys energy from a remote supplier, the local distributor only provides transportation facilities for the energy and is compensated accordingly. Transmission and distribution have remained monopolized and regulated by the Norwegian Water Resources and Energy

  19. Topics on Electricity Transmission Pricing

    Energy Technology Data Exchange (ETDEWEB)

    Bjoerndal, Mette

    2000-02-01

    Within the last decade we have experienced deregulation of several industries, such as airlines, telecommunications and the electric utility industry, the last-mentioned being the focus of this work. Both the telecommunications and the electricity sector depend on network facilities, some of which are still considered as natural monopolies. In these industries, open network access is regarded as crucial in order to achieve the gains from increased competition, and transmission tariffs are important in implementing this. Based on the Energy Act that was introduced in 1991, Norway was among the first countries to restructure its electricity sector. On the supply side there are a large number of competing firms, almost exclusively hydro plants, with a combined capacity of about 23000 MW, producing 105-125 TWh per year, depending on the availability of water. Hydro plants are characterized by low variable costs of operation, however since water may be stored in dams, water has an opportunity cost, generally known as the water value, which is the shadow price of water when solving the generator's inter temporal profit maximization problem. Water values are the main factor of the producers' short run marginal cost. Total consumption amounts to 112-117 TWh a year, and consumers, even households, may choose their electricity supplier independent of the local distributor to which the customer is connected. In fact, approximately 10% of the households have actually changed supplier. The web-site www.konkurransetilsynet.no indicates available contracts, and www.dinside.no provides an ''energy-calculator'' where one can check whether it is profitable to switch supplier. If a customer buys energy from a remote supplier, the local distributor only provides transportation facilities for the energy and is compensated accordingly. Transmission and distribution have remained monopolized and regulated by the Norwegian Water Resources and Energy

  20. 47 CFR 73.875 - Modification of transmission systems.

    Science.gov (United States)

    2010-10-01

    ... transmission system facilities. (a) The following changes are prohibited: (1) Those that would result in the.... (2) Those that would cause the transmission system to exceed the equipment performance measurements... test operations at the full authorized ERP may commence immediately upon installation pursuant to §...

  1. Effects of transmission on Gaussian optical states.

    Science.gov (United States)

    McKinstrie, C J; Marshall, K; Weedbrook, C

    2015-04-20

    The noise properties of phase-insensitive and phase-sensitive optical transmission links are described in detail, for Gaussian input signals. Formulas are derived for the quadrature covariance matrices of the output signals, which allow one to quantify the noise figures of the links and the fidelities of transmission. Another formula is derived, which relates the density operator of an output signal, in the number-state representation, to its covariance matrix. This density matrix allows one to quantify the decrease in coherence and changes in photon-number probabilities associated with transmission. Based on the aforementioned performance metrics, links with distributed phase-sensitive amplification perform significantly better than other links. PMID:25969122

  2. Alberta's transmission development policy : review and recommendations

    International Nuclear Information System (INIS)

    Alberta's Department of Energy (ADOE) released a policy paper in November 2003 regarding power transmission development for the province. The transmission development policy (TDP) is intended to promote economic growth in Alberta while ensuring consumers with reliable, reasonably priced electricity. This presentation reviewed the main features of the policy and then focused on the allocation of costs to generation customers. The author argued that the proposed changes would result in a sub-optimal development of generation and higher total electricity bills for consumers. He argued that the policy will spare generation customers of any obligation to pay wire-related costs other than local interconnection costs. This would weaken a long-standing ADOE policy which requires generators to pay costs that depend on their location on the transmission system. With the new proposal, generators would not be responsible for ancillary service costs even when they provide direct benefits, and they would pay for system losses on a zonal basis. The author recommended that location charges should be large enough to influence the siting decisions of generators. He also recommended that generators should pay their fare share of transmission use-of-system charges, including ancillary services that provide benefits to generators in the form of a stable, reliable transmission system. 2 tabs., 2 figs

  3. Research and Transmission

    Directory of Open Access Journals (Sweden)

    Denise Pumain

    2001-01-01

    Full Text Available The present situation provides a challenge for us to reconsider the necessary link between science and pedagogy, between research and the transmission of knowledge. The Ministry of National education has just inaugurated a broad consultation of teachers on every level with a view to modernising and giving coherence to the programs of secondary education. Armand Frémont will head the group of experts responsible for history and geography. Is this a coincidence? The changeover in the jury for t...

  4. Coaxial transmission line - Equalization

    International Nuclear Information System (INIS)

    The transmission of electrical signal through a coaxial line is not perfect and signal distortions are increased as much as the frequency spectrum is extended. We have designed and achieved passive filters (named equalizers) with transfer functions which are inverse of coaxial transfer functions. Doing so our attempt is to avoid definitive loss of information in the recorded data. The main feature of our equalization method lies in the fact it could be either an electrical or a numerical correction or both of them. Some examples in the use of this technique are also proposed

  5. Dynamic stable set

    OpenAIRE

    Hannu Vartiainen

    2008-01-01

    We study a dynamic vNM stable set in a compact metric space under the assumption of complete and continuous dominance relation. Internal and external stability are defined with respect to farsighted dominance. Stability of an outcome is conditioned on the history via which it is reached. A dynamic stable set always exists. Any covering set by Dutta (1988) coincides with the set of outcomes that are implementable via a dynamic stable set. The maximal implementable outcome set is a version of t...

  6. Invariant sets for Windows

    CERN Document Server

    Morozov, Albert D; Dragunov, Timothy N; Malysheva, Olga V

    1999-01-01

    This book deals with the visualization and exploration of invariant sets (fractals, strange attractors, resonance structures, patterns etc.) for various kinds of nonlinear dynamical systems. The authors have created a special Windows 95 application called WInSet, which allows one to visualize the invariant sets. A WInSet installation disk is enclosed with the book.The book consists of two parts. Part I contains a description of WInSet and a list of the built-in invariant sets which can be plotted using the program. This part is intended for a wide audience with interests ranging from dynamical

  7. Codes from difference sets

    CERN Document Server

    Ding, Cunsheng

    2014-01-01

    This is the first monograph on codebooks and linear codes from difference sets and almost difference sets. It aims at providing a survey of constructions of difference sets and almost difference sets as well as an in-depth treatment of codebooks and linear codes from difference sets and almost difference sets. To be self-contained, this monograph covers necessary mathematical foundations and the basics of coding theory. It also contains tables of best BCH codes and best cyclic codes over GF(2) and GF(3) up to length 125 and 79, respectively. This repository of tables can be used to benchmark

  8. Sets resilient to erosion

    CERN Document Server

    Pegden, Wesley

    2011-01-01

    The erosion of a set in Euclidean space by a radius r>0 is the subset of X consisting of points at distance >/-r from the complement of X. A set is resilient to erosion if it is similar to its erosion by some positive radius. We give a somewhat surprising characterization of resilient sets, consisting in one part of simple geometric constraints on convex resilient sets, and, in another, a correspondence between nonconvex resilient sets and scale-invariant (e.g., 'exact fractal') sets.

  9. aTmcam: A Simple Atmospheric Transmission Monitoring Camera For Sub 1% Photometric Precision

    CERN Document Server

    Li, Ting; Kessler, R; Burke, D L; Marshall, J L; Wise, J; Rheault, J -P; Carona, D W; Boada, S; Prochaska, T; Allen, R

    2013-01-01

    Traditional color and airmass corrections can typically achieve ~0.02 mag precision in photometric observing conditions. A major limiting factor is the variability in atmospheric throughput, which changes on timescales of less than a night. We present preliminary results for a system to monitor the throughput of the atmosphere, which should enable photometric precision when coupled to more traditional techniques of less than 1% in photometric conditions. The system, aTmCam, consists of a set of imagers each with a narrow-band filter that monitors the brightness of suitable standard stars. Each narrowband filter is selected to monitor a different wavelength region of the atmospheric transmission, including regions dominated by the precipitable water absorption and aerosol scattering. We have built a prototype system to test the notion that an atmospheric model derived from a few color indices measurements can be an accurate representation of the true atmospheric transmission. We have measured the atmospheric t...

  10. A Procedure for Socially Valid Goal Setting

    Science.gov (United States)

    Ogletree, Billy T.; Howell, Amber; Carpenter, Dale

    2005-01-01

    Goal setting poses a significant challenge for service providers in both clinical and educational settings. With today's call for services that contribute to meaningful changes in children, there is an increased need for goal-setting procedures that are socially valid. This article presents such a procedure and illustrates its use through a case…

  11. Set-Valued Graphs

    Directory of Open Access Journals (Sweden)

    Kumar Abhishek

    2012-08-01

    Full Text Available A {it set-indexer} of a given graph $G = (V, E$ is an assignment $f$ of distinct nonempty subsets of a finite nonempty 'ground set' $X$ of cardinality $n$ to the vertices of $G$ so that the values $f^{oplus}(e, e=uv in E,$ obtained as the symmetric differences $f(u oplus f(v$ of the subsets $f(u$ and $f(v$ of $X,$ are all distinct. A set-indexer $f$ of a graph $G,$ is called a {it segregation} of $X$ on $G$ if the sets $f(V(G = {f(u: u in V(G}$ and $f^{oplus}(E(G = {f^{oplus}(e: e in E(G}$ are disjoint, and if, in addition, their union is the set $Y(X = mathcal{P}(X-{emptyset}$ of all the nonempty subsets of $X$ where $mathcal{P}(X$ denotes the power set of $X,$ then $f$ is called a {it set-sequential labeling} of $G.$ A graph is hence called {it set-sequential} if it admits a set-sequential labeling with respect to some 'ground set' $X.$ A set-indexer $f$ of a $(p, q$-graph $G = (V, E$ is called a {it set-graceful labeling} of $G$ if there exists nonempty ground set $X$ such that $f^{oplus}(E = mathcal{P}(X-{emptyset}$ and $G$ is {it set-graceful} if it admits a set-graceful labeling. In this report we provide a complete characterization of set-sequential caterpillar of diameter four. We also a provide a new necessary condition for a graph to be set-sequential.

  12. Airborne transmission of lyssaviruses.

    Science.gov (United States)

    Johnson, N; Phillpotts, R; Fooks, A R

    2006-06-01

    In 2002, a Scottish bat conservationist developed a rabies-like disease and subsequently died. This was caused by infection with European bat lyssavirus 2 (EBLV-2), a virus closely related to Rabies virus (RABV). The source of this infection and the means of transmission have not yet been confirmed. In this study, the hypothesis that lyssaviruses, particularly RABV and the bat variant EBLV-2, might be transmitted via the airborne route was tested. Mice were challenged via direct introduction of lyssavirus into the nasal passages. Two hours after intranasal challenge with a mouse-adapted strain of RABV (Challenge Virus Standard), viral RNA was detectable in the tongue, lungs and stomach. All of the mice challenged by direct intranasal inoculation developed disease signs by 7 days post-infection. Two out of five mice challenged by direct intranasal inoculation of EBLV-2 developed disease between 16 and 19 days post-infection. In addition, a simple apparatus was evaluated in which mice could be exposed experimentally to infectious doses of lyssavirus from an aerosol. Using this approach, mice challenged with RABV, but not those challenged with EBLV-2, were highly susceptible to infection by inhalation. These data support the hypothesis that lyssaviruses, and RABV in particular, can be spread by airborne transmission in a dose-dependent manner. This could present a particular hazard to personnel exposed to aerosols of infectious RABV following accidental release in a laboratory environment. PMID:16687600

  13. Broadband transmission EPR spectroscopy.

    Directory of Open Access Journals (Sweden)

    Wilfred R Hagen

    Full Text Available EPR spectroscopy employs a resonator operating at a single microwave frequency and phase-sensitive detection using modulation of the magnetic field. The X-band spectrometer is the general standard with a frequency in the 9-10 GHz range. Most (biomolecular EPR spectra are determined by a combination of the frequency-dependent electronic Zeeman interaction and a number of frequency-independent interactions, notably, electron spin - nuclear spin interactions and electron spin - electron spin interactions, and unambiguous analysis requires data collection at different frequencies. Extant and long-standing practice is to use a different spectrometer for each frequency. We explore the alternative of replacing the narrow-band source plus single-mode resonator with a continuously tunable microwave source plus a non-resonant coaxial transmission cell in an unmodulated external field. Our source is an arbitrary wave digital signal generator producing an amplitude-modulated sinusoidal microwave in combination with a broadband amplifier for 0.8-2.7 GHz. Theory is developed for coaxial transmission with EPR detection as a function of cell dimensions and materials. We explore examples of a doublet system, a high-spin system, and an integer-spin system. Long, straigth, helical, and helico-toroidal cells are developed and tested with dilute aqueous solutions of spin label hydroxy-tempo. A detection limit of circa 5 µM HO-tempo in water at 800 MHz is obtained for the present setup, and possibilities for future improvement are discussed.

  14. Landslides, Set 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This set expands the topics included in Set 1 and includes (in addition to landslides) rockfalls, rock avalanches, mud flows, debris flows, slumps, creep, and...

  15. Value Set Authority Center

    Data.gov (United States)

    U.S. Department of Health & Human Services — The VSAC provides downloadable access to all official versions of vocabulary value sets contained in the 2014 Clinical Quality Measures (CQMs). Each value set...

  16. Altimeter Setting Indicator

    Data.gov (United States)

    Department of Transportation — The Altimeter Setting Indicator (ASI) is an aneroid system used at airports to provide an altimeter setting for aircraft altimeters. This indicator may be an analog...

  17. Neutrosophic Crisp Set & Relations

    OpenAIRE

    A. A. Salama; Hewayda ElGhawalby

    2014-01-01

    In a world full of indeterminacy, traditional crisp set with its boundaries of truth and false has not infused itself with the ability of reflecting the reality. Therefore, neutrosophic found its place into contemporary research as an alternative representation of the real world. In this paper, we aim to develop a new type of neutrosophic crisp sets called the *-Neutrosophic crisp sets as a generaliza tion of the star intuitionistic set introduced by Indira et al.[4] , and hence studying s...

  18. Axiomatic set theory

    CERN Document Server

    Suppes, Patrick

    1972-01-01

    This clear and well-developed approach to axiomatic set theory is geared toward upper-level undergraduates and graduate students. It examines the basic paradoxes and history of set theory and advanced topics such as relations and functions, equipollence, finite sets and cardinal numbers, rational and real numbers, and other subjects. 1960 edition.

  19. Sets, Planets, and Comets

    Science.gov (United States)

    Baker, Mark; Beltran, Jane; Buell, Jason; Conrey, Brian; Davis, Tom; Donaldson, Brianna; Detorre-Ozeki, Jeanne; Dibble, Leila; Freeman, Tom; Hammie, Robert; Montgomery, Julie; Pickford, Avery; Wong, Justine

    2013-01-01

    Sets in the game "Set" are lines in a certain four-dimensional space. Here we introduce planes into the game, leading to interesting mathematical questions, some of which we solve, and to a wonderful variation on the game "Set," in which every tableau of nine cards must contain at least one configuration for a player to pick up.

  20. Paired fuzzy sets

    DEFF Research Database (Denmark)

    Rodríguez, J. Tinguaro; Franco de los Ríos, Camilo; Gómez, Daniel;

    2015-01-01

    In this paper we want to stress the relevance of paired fuzzy sets, as already proposed in previous works of the authors, as a family of fuzzy sets that offers a unifying view for different models based upon the opposition of two fuzzy sets, simply allowing the existence of different types of...

  1. Improving the Energy Market: Algorithms, Market Implications, and Transmission Switching

    Science.gov (United States)

    Lipka, Paula Ann

    corresponding to the accuracy and AC-feasiblity of the solution. This linearization was tested on the IEEE and Polish systems, which range from 14 to 3375 buses and 20 to 4161 transmission lines. It had an accuracy of 0.5% or less for all but the 30-bus system. It also solved in linear time with CPLEX, while the non-linear version solved in O(n1.11) to O(n1.39). The sequential linearization is slower than the nonlinear formulation for smaller problems, but faster for larger problems, and its linear computational time means it would continue solving faster for larger problems. A major consideration to implementing algorithms to solve the optimal generator dispatch is ensuring that the resulting prices from the algorithm will support the market. Since the sequential linearization is linear, it is convex, its marginal values are well-defined, and there is no duality gap. The prices and settlements obtained from the sequential linearization therefore can be used to run a market. This market will include extra prices and settlements for reactive power and voltage, compared to the present-day market, which is based on real power. An advantage of this is that there is a very clear pool that can be used for reactive power/voltage support payments, while presently there is not a clear pool to take them out of. This method also reveals how valuable reactive power and voltage are at different locations, which can enable better planning of reactive resource construction. Transmission switching increases the feasible region of the generator dispatch, which means there may be a better solution than without transmission switching. Power flows on transmission lines are not directly controllable; rather, the power flows according to how it is injected and the physical characteristics of the lines. Changing the network topology changes the physical characteristics, which changes the flows. This means that sets of generator dispatch that may have previously been infeasible due to the flow

  2. Characterizing the transmission potential of zoonotic infections from minor outbreaks.

    Science.gov (United States)

    Kucharski, Adam J; Edmunds, W John

    2015-04-01

    The transmission potential of a novel infection depends on both the inherent transmissibility of a pathogen, and the level of susceptibility in the host population. However, distinguishing between these pathogen- and population-specific properties typically requires detailed serological studies, which are rarely available in the early stages of an outbreak. Using a simple transmission model that incorporates age-stratified social mixing patterns, we present a novel method for characterizing the transmission potential of subcritical infections, which have effective reproduction number Rpre-existing immunity to MERS-CoV in humans. The approach we describe can therefore provide crucial information about novel infections before serological surveys and other detailed analyses are available. The methods would also be applicable to data stratified by factors such as profession or location, which would make it possible to measure the transmission potential of emerging infections in a wide range of settings. PMID:25860289

  3. Design and Transmission Analysis of an Asymmetrical Spherical Parallel Manipulator

    DEFF Research Database (Denmark)

    Wu, Guanglei; Caro, Stéphane; Wang, Jiawei

    2015-01-01

    This paper presents an asymmetrical spherical parallel manipulator and its transmissibility analysis. This manipulator contains a center shaft to both generate a decoupled unlimited-torsion motion and support the mobile platform for high positioning accuracy. This work addresses the transmission...... analysis and optimal design of the proposed manipulator based on its kinematic analysis. The input and output transmission indices of the manipulator are defined for its optimum design based on the virtual coefficient between the transmission wrenches and twist screws. The sets of optimal parameters are...... identified and the distribution of the transmission index is visualized. Moreover, a comparative study regarding to the performances with the symmetrical spherical parallel manipulators is conducted and the comparison shows the advantages of the proposed manipulator with respect to its spherical parallel...

  4. SET Backaction on the Single Electron Box

    OpenAIRE

    Turek, B. A.; Lehnert, K. W.; Clerk, A.; Gunnarsson, D.; Bladh, K.; Delsing, P.; Schoelkopf, R. J.

    2005-01-01

    We report an experimental observation of the backaction of a Single Electron Transistor (SET) measuring the Coulomb staircase of a single electron box. As current flows through the SET, the charge state of the SET island fluctuates. These fluctuations capacitively couple to the box and cause changes in the position, width, and asymmetry of the Coulomb staircase. A sequential tunnelling model accurately recreates these effects, confirming this mechanism of the backaction of an SET. This is a f...

  5. Household Transmission of Vibrio cholerae in Bangladesh.

    Directory of Open Access Journals (Sweden)

    Jonathan D Sugimoto

    2014-11-01

    Full Text Available Vibrio cholerae infections cluster in households. This study's objective was to quantify the relative contribution of direct, within-household exposure (for example, via contamination of household food, water, or surfaces to endemic cholera transmission. Quantifying the relative contribution of direct exposure is important for planning effective prevention and control measures.Symptom histories and multiple blood and fecal specimens were prospectively collected from household members of hospital-ascertained cholera cases in Bangladesh from 2001-2006. We estimated the probabilities of cholera transmission through 1 direct exposure within the household and 2 contact with community-based sources of infection. The natural history of cholera infection and covariate effects on transmission were considered. Significant direct transmission (p-value<0.0001 occurred among 1414 members of 364 households. Fecal shedding of O1 El Tor Ogawa was associated with a 4.9% (95% confidence interval: 0.9%-22.8% risk of infection among household contacts through direct exposure during an 11-day infectious period (mean length. The estimated 11-day risk of O1 El Tor Ogawa infection through exposure to community-based sources was 2.5% (0.8%-8.0%. The corresponding estimated risks for O1 El Tor Inaba and O139 infection were 3.7% (0.7%-16.6% and 8.2% (2.1%-27.1% through direct exposure, and 3.4% (1.7%-6.7% and 2.0% (0.5%-7.3% through community-based exposure. Children under 5 years-old were at elevated risk of infection. Limitations of the study may have led to an underestimation of the true risk of cholera infection. For instance, available covariate data may have incompletely characterized levels of pre-existing immunity to cholera infection. Transmission via direct exposure occurring outside of the household was not considered.Direct exposure contributes substantially to endemic transmission of symptomatic cholera in an urban setting. We provide the first estimate of

  6. Sets avoiding integral distances

    CERN Document Server

    Kurz, Sascha

    2012-01-01

    We study open point sets in Euclidean spaces $\\mathbb{R}^d$ without a pair of points an integral distance apart. By a result of Furstenberg, Katznelson, and Weiss such sets must be of Lebesgue upper density zero. We are interested in how large such sets can be in $d$-dimensional volume. We determine the lower and upper bounds for the volumes of the sets in terms of the number of their connected components and dimension, and also give some exact values. Our problem can be viewed as a kind of inverse to known problems on sets with pairwise rational or integral distances.

  7. Elements of set theory

    CERN Document Server

    Enderton, Herbert B

    1977-01-01

    This is an introductory undergraduate textbook in set theory. In mathematics these days, essentially everything is a set. Some knowledge of set theory is necessary part of the background everyone needs for further study of mathematics. It is also possible to study set theory for its own interest--it is a subject with intruiging results anout simple objects. This book starts with material that nobody can do without. There is no end to what can be learned of set theory, but here is a beginning.

  8. Fuel, environmental, and transmission pricing considerations in a deregulated environment

    Science.gov (United States)

    Obessis, Emmanouil Vlassios

    The 1992 National Energy Policy Act drastically changed the traditional structure of the vertically integrated utility. To facilitate increased competition in the power utility sector, all markets related to power generation have been opened to free competition and trading. To survive in the new competitive environment, power producers need to reduce costs and increase efficiency. Fuel marketing strategies are thus, getting more aggressive and fuel markets are becoming more competitive, offering more options regarding fuel supplies and contracts. At the same time, the 1990 Clean Air Act Amendments are taking effect. Although tightening the emission standards, this legislation offers utilities a wider flexibility in choosing compliance strategies. It also set maximum annual allowable levels replacing the traditional uniform maximum emission rates. The bill also introduced the concept of marketable emission allowances and provided for the establishment of nationwide markets where allowances may be traded, sold, or purchased. Several fuel- and emission-constrained algorithms have been historically presented, but those two classes of constraints, in general, were handled independently. The multiobjective optimization model developed in this research work, concurrently satisfies sets of detailed fuel and emission limits, modeling in a more accurate way the fuel supply and environmental limitations and their complexities in the new deregulated operational environment. Development of the implementation software is an integral part of this research project. This software may be useful for both daily scheduling activities and short-term operational planning. A Lagrangian multipliers-based variant is used to solve the problem. Single line searches are used to update the multipliers, thus offering attractive execution times. This work also investigates the applicability of cooperative games to the problem of transmission cost allocation. Interest in game theory as a powerful

  9. Gas transmission pricing

    International Nuclear Information System (INIS)

    The natural gas transmission system consists of facilities that are normally regarded as being a natural monopoly. This is a property the natural gas network share with the telecommunication and the electricity network. All of these networks have, to some degree, been deregulated during the last decades. The deregulation of the natural gas network was in Europe formalized when the gas directive was passed in the European Commission 22 June 1998. This directive opens for third party access to the transportation facilities in the natural gas network. Open network access is important in order to achieve gains from increased competition, and transmission tariffs are important in achieving this. Due to the technical nature of the gas network, several physical and technical threshold values exist. If such values are trespassed, only minor incremental deliveries in on part can cause significant unintended reductions elsewhere. When performing analyses on optimal operation of a natural gas network, it is therefore necessary to take into consideration these properties. In this paper the physical properties of the natural gas flow are modeled by taking into account the design parameters of the pipelines in the system and the effects of pressure difference between the nodes in the network. The connection between pressure difference and gas flow is handled with the Weymouth-equation. A quadratic optimization model is constructed in order to analyze operation of the network. This paper examines how the efficiency of the natural gas market is affected by the operation and pricing of the transmission system. The tariff regimes investigated include fixed fees, nodal pricing, Chao-Peck pricing and zonal pricing. An examination of the existing tariff-regime in the North-Sea will also be performed as well as a comparison with the above mentioned tariff mechanisms. To perform the analyses, an example network will be presented and analyzed. By combining the physical flow calculations

  10. Multidimensional set switching.

    Science.gov (United States)

    Hahn, Sowon; Andersen, George J; Kramer, Arthur F

    2003-06-01

    The present study examined the organization of preparatory processes that underlie set switching and, more specifically, switch costs. On each trial, subjects performed one of two perceptual judgment tasks, color or shape discrimination. Subjects also responded with one of two different response sets. The task set and/or the response set switched from one to the other after 2-6 repeated trials. Response set, task set, and double set switches were performed in both blocked and randomized conditions. Subjects performed with short (100-msec) and long (800-msec) preparatory intervals. Task and response set switches had an additive effect on reaction times (RTs) in the blocked condition. Such a pattern of results suggests a serial organization of preparatory processes when the nature of switches is predictable. However, task and response set switches had an underadditive effect on RTs in the random condition when subjects performed with a brief cue-to-target interval. This pattern of results suggests overlapping task and response set preparation. These findings are discussed in terms of strategic control of preparatory processes in set switching. PMID:12921431

  11. Aerobiology and Its Role in the Transmission of Infectious Diseases

    OpenAIRE

    Aaron Fernstrom; Michael Goldblatt

    2013-01-01

    Aerobiology plays a fundamental role in the transmission of infectious diseases. As infectious disease and infection control practitioners continue employing contemporary techniques (e.g., computational fluid dynamics to study particle flow, polymerase chain reaction methodologies to quantify particle concentrations in various settings, and epidemiology to track the spread of disease), the central variables affecting the airborne transmission of pathogens are becoming better known. This paper...

  12. Wealth Transmission and Inequality Among Hunter-Gatherers

    OpenAIRE

    Smith, Eric Alden; Hill, Kim; Marlowe, Frank; Nolin, David; Wiessner, Polly; Gurven, Michael; Bowles, Samuel; Mulder, Monique Borgerhoff; Hertz, Tom; Bell, Adrian

    2010-01-01

    We report quantitative estimates of intergenerational transmission and population-wide inequality for wealth measures in a set of hunter-gatherer populations. Wealth is defined broadly as factors that contribute to individual or household well-being, ranging from embodied forms such as weight and hunting success to material forms such household goods, as well as relational wealth in exchange partners. Intergenerational wealth transmission is low to moderate in these populations, but is still ...

  13. Adaptive Sensing and Transmission Durations for Cognitive Radios

    OpenAIRE

    Afifi, Wessam; Sultan, Ahmed; Nafie, Mohammed

    2010-01-01

    In a cognitive radio setting, secondary users opportunistically access the spectrum allocated to primary users. Finding the optimal sensing and transmission durations for the secondary users becomes crucial in order to maximize the secondary throughput while protecting the primary users from interference and service disruption. In this paper an adaptive sensing and transmission scheme for cognitive radios is proposed. We consider a channel allocated to a primary user which operates in an unsl...

  14. FPGA Implementation of Video Transmission System Based on LTE

    OpenAIRE

    Lu Yan; Zhang Qianlong; Tang An

    2015-01-01

    In order to support high-definition video transmission, an implementation of video transmission system based on Long Term Evolution is designed. This system is developed on Xilinx Virtex-6 FPGA ML605 Evaluation Board. The paper elaborates the features of baseband link designed in Xilinx ISE and protocol stack designed in Xilinx SDK, and introduces the process of setting up hardware and software platform in Xilinx XPS. According to test, this system consumes less hardware resource and is able ...

  15. Transmission rights and market power

    International Nuclear Information System (INIS)

    Most of the concerns about physical transmission rights relate to the ability to implicitly or explicitly remove that transmission capacity from the market-place. Under a very strict form of physical right, owners could simply choose not to sell it if they don't want to use it. Modifications that require the release of spare capacity back into an open market could potentially alleviate this problem but there is concern that such releases would not occur far enough in advance to be of much use to schedulers. Similarly, the transmission capacity that is made available for use by non-rights holders can also be manipulated by the owners of transmission rights. The alternative form, financial transmission rights, provide to their owners congestion payments, but physical control of transmission paths. In electricity markets such as California's, even financial transmission rights could potentially be utilized to effectively withhold transmission capacity from the marketplace. However, methods for withholding transmission capacity are somewhat more convoluted, and probably more difficult, for owners of financial rights than for owners of physical rights. In this article, the author discusses some of the potential concerns over transmission rights and their use for the exercise of various forms of market power

  16. Thrips transmission of tospoviruses.

    Science.gov (United States)

    Rotenberg, Dorith; Jacobson, Alana L; Schneweis, Derek J; Whitfield, Anna E

    2015-12-01

    One hundred years ago, the disease tomato spotted wilt was first described in Australia. Since that time, knowledge of this disease caused by Tomato spotted wilt virus (TSWV) and transmitted by thrips (insects in the order Thysanoptera) has revealed a complex relationship between the virus, vector, plant host, and environment. Numerous tospoviruses and thrips vectors have been described, revealing diversity in plant host range and geographical distributions. Advances in characterization of the tripartite interaction between the virus, vector, and plant host have provided insight into molecular and ecological relationships. Comparison to animal-infecting viruses in the family Bunyaviridae has enabled the identification of commonalities between tospoviruses and other bunyaviruses in transmission by arthropod vectors and molecular interactions with hosts. This review provides a special emphasis on TSWV and Frankliniella occidentalis, the model tospovirus-thrips pathosystem. However, other virus-vector combinations are also of importance and where possible, comparisons are made between different viruses and thrips vectors. PMID:26340723

  17. Astrocytes Potentiate Synaptic Transmission

    Science.gov (United States)

    Nadkarni, Suhita

    2005-03-01

    A recent experimental study shows that astrocytes, a subtype of glia, are able to influence the spontaneous activity in the brain via calcium dependent glutamate release. We model the coupling mechanism between an astrocyte and a neuron based on experimental data. This coupling is dynamic and bi-directional, such that the modulations in intracellular calcium concentrations in astrocytes affect neuronal excitability and vice versa via a glutamatergic pathway. We demonstrate through simple neural-glial circuits that increases in the intracellular calcium concentration in astrocytes nearby can enhance spontaneous activity in a neuron, a significant mechanism said to be involved in plasticity and learning. The pattern of this marked increase in spontaneous firing rate in our model quantitatively follows that observed in the experiment. Further, depending on the type of synaptic connections diverging from the neuron, it can either inhibit or excite the ensuing dynamics and potentiate synaptic transmission, thus reinstating the integral role played by astrocytes in normal neuronal dynamics.

  18. Stress transmission in soil

    DEFF Research Database (Denmark)

    Lamandé, Mathieu; Schjønning, Per

    We urgently need increased quantitative knowledge on stress transmission in real soils loaded with agricultural machinery. 3D measurements of vertical stresses under tracked wheels were performed in situ in a Stagnic Luvisol (clay content 20 %) continuously cropped with small grain cereals. The......). Seven load cells were inserted horizontally from a pit with minimal disturbance of soil in each of three depths (0.3, 0.6 and 0.9 m), covering the width of the wheeled area. The position of the wheel relative to the transducers was recorded using a laser sensor. Finally, the vertical stresses near the...... soil-tyre interface were measured in separate tests by 17 stress transducers across the width of the tyres. The results showed that the inflation pressure controlled the level of maximum stresses at 0.3 m depth, while the wheel load was correlated to the measured stresses at 0.9 m depth. This supports...

  19. Information transmission strategy

    International Nuclear Information System (INIS)

    The four propositions on which our radiation protection information transmission strategy is based are as follows: 1. Emotion exists. It rules our lives at work as well as at home, particularly when radiation safety is involved. Emotion is therefore the terrain for our strategy. 2. The basic emotion is that of fear. This must be recognized and accepted if we want to transmit objective information. The basis of our strategy is therefore listening. 3. A person cannot be divided into parts. The whole person is concerned about safety. We have to deal with that whole person. 4. To follow a strategy we need strategists. We must look at our own emotions and our own motivation before going into the field

  20. Fiber optic data transmission

    Science.gov (United States)

    Shreve, Steven T.

    1987-01-01

    The Ohio University Avionics Engineering Center is currently developing a fiber optic data bus transmission and reception system that could eventually replace copper cable connections in airplanes. The original form of the system will transmit information from an encoder to a transponder via a fiber optic cable. An altimeter and an altitude display are connected to a fiber optic transmitter by copper cable. The transmitter converts the altimetry data from nine bit parallel to serial form and send these data through a fiber optic cable to a receiver. The receiver converts the data using a cable similar to that used between the altimeter and display. The transmitting and receiving ends also include a display readout. After completion and ground testing of the data bus, the system will be tested in an airborne environment.

  1. Hydatidosis: dynamics of transmission.

    Science.gov (United States)

    Bourée, P

    2001-01-01

    Hydatidosis is a widespread zoonosis infecting a large number of animals and humans. Echinococcus granulosus has the smallest taenia adult of the cestodes but with the largest larva. Its morphologic and biologic features were identified with DNA analysis. Different strains were separated according to the intermediate hosts: sheep, cattle, pigs, horses, camels. Definitive host are canids, mostly dogs, where the worm grows to adulthood in several months. The eggs are scattered in the pasture by wind and water and are ingested by various hosts. The larvae migrate through the intestinal wall and penetrate the organs, mostly liver and lungs. The eggs survive several days outside, depending on the temperature, but numerous eggs die in nature because they cannot resist desiccation and extreme temperatures. Dissemination is accomplished by dogs. In Turkana (Kenya) the incidence of hydatidosis is high because of the close relationship between the population and dogs and the habit of leaving their dead bodies in the grasslands. In rural areas, the custom of slaughtering sheep at home, among the dogs, is an important dissemination factor. The circumstances of transmission vary according to the country. In Europe the natural life cycle of E. granulosus granulosus involves dogs as the definitive host and sheep as the intermediate host. In northern Europe E. granulosus borealis infects the canids and deer. E. granulosus canadensis infects wolves and reindeer, but there are no human cases. In the endemic Mediterranean area, sheep and dromedaries are the intermediate hosts. In South America, the life cycle of E. granulosus develops among several definitive and intermediate hosts. Hence the dynamics of transmission vary according to the countries with different hosts. PMID:11213154

  2. Swing Set Irrigation System

    Directory of Open Access Journals (Sweden)

    Ambe Verma

    2015-05-01

    Full Text Available ABSTRACT India is a vast country based on agriculture and irrigation is the most important factor for agriculture. In India there are many sources provide for irrigation. Every day new technologies are emerged in the world which brings a revolutionary change in the nature of this world. day by day the energy resources used by the large population of this world are coming on the last stage This project give the idea that how the other different form of energy can be used and implemented efficiently to overcome from this problem The aim of this project is to achieve the objective of energy lasting problem which is likely to be faced over in coming decades. Energy lasting is a big problem in India. This is faced by every people who live in the country. Swing energy is the form of energy. In this paper we have represented the methodology of swing energy using for rural area of application. This paper is all about Swing Set Water Pump in which the water pump will execute with the help of a swing set of canopy type. As we need a motor to operate the water pump but in this project we use the swing in the place of motor and we use oscillatory motion of swing in the place of rotating motion of a motor. Everybody has needed the energy at an increasing rate ever since he came on the Earth. Because of this lot of energy has been exhausted and wasted. All the member are dedicated the amount of their important time to participate in multiple meetings read and research for making the content to the report. We would especially like to thanks for the efficient condition of the entire Advisory member and their experiences. This study was initial and performed within the BUDDHA INSTITUTE OF TECHNOLOGY GIDA Gorakhpur the final report represents the labour and interest of the entire member working for this project. Finally we would like to thanks to all the member of our college workshop who helped us in manufacturing of this project model.

  3. A data set of worldwide glacier fluctuations

    OpenAIRE

    P. W. Leclercq; Oerlemans, J.; H. J. Basagic; I. Bushueva; Cook, A. J.; Le Bris, R.

    2014-01-01

    Glacier fluctuations contribute to variations in sea level and historical glacier length fluctuations are natural indicators of past climate change. To study these subjects, longterm information of glacier change is needed. In this paper we present a data set of global long-term glacier length fluctuations. The data set is a compilation of available information on changes in glacier length worldwide, including both measured and reconstructed glacier length fluctuations. All 471 length series ...

  4. Facts controllers in power transmission and distribution

    CERN Document Server

    Padiyar, KR

    2007-01-01

    About the Book: The emerging technology of Flexible AC Transmission System (FACTS) enables planning and operation of power systems at minimum costs, without compromising security. This is based on modern high power electronic systems that provide fast controllability to ensure ''flexible'' operation under changing system conditions. This book presents a comprehensive treatment of the subject by discussing the operating principles, mathematical models, control design and issues that affect the applications. The concepts are explained often with illustrative examples and case studies. In partic

  5. A new MCNP{trademark} test set

    Energy Technology Data Exchange (ETDEWEB)

    Brockhoff, R.C.; Hendricks, J.S.

    1994-09-01

    The MCNP test set is used to test the MCNP code after installation on various computer platforms. For MCNP4 and MCNP4A this test set included 25 test problems designed to test as many features of the MCNP code as possible. A new and better test set has been devised to increase coverage of the code from 85% to 97% with 28 problems. The new test set is as fast as and shorter than the MCNP4A test set. The authors describe the methodology for devising the new test set, the features that were not covered in the MCNP4A test set, and the changes in the MCNP4A test set that have been made for MCNP4B and its developmental versions. Finally, new bugs uncovered by the new test set and a compilation of all known MCNP4A bugs are presented.

  6. A new MCNP trademark test set

    International Nuclear Information System (INIS)

    The MCNP test set is used to test the MCNP code after installation on various computer platforms. For MCNP4 and MCNP4A this test set included 25 test problems designed to test as many features of the MCNP code as possible. A new and better test set has been devised to increase coverage of the code from 85% to 97% with 28 problems. The new test set is as fast as and shorter than the MCNP4A test set. The authors describe the methodology for devising the new test set, the features that were not covered in the MCNP4A test set, and the changes in the MCNP4A test set that have been made for MCNP4B and its developmental versions. Finally, new bugs uncovered by the new test set and a compilation of all known MCNP4A bugs are presented

  7. aTmcam: A Simple Atmospheric Transmission Monitoring Camera For Sub 1 Percent Photometric Precision

    Science.gov (United States)

    Li, T.; DePoy, D. L.; Kessler, R.; Burke, D. L.; Marshall, J. L.; Wise, J.; Rheault, J.-P.; Carona, D. W.; Boada, S.; Prochaska, T.; Allen, R.

    2016-05-01

    Traditional color and airmass corrections can typically achieve ˜0.02 mag precision in photometric observing conditions. A major limiting factor is the variability in atmospheric throughput, which changes on timescales of less than a night. We present preliminary results for a system to monitor the throughput of the atmosphere, which should enable photometric precision when coupled to more traditional techniques of less than 1% in photometric conditions. The system, aTmCam, consists of a set of imagers each with a narrow-band filter that monitors the brightness of suitable standard stars. Each narrowband filter is selected to monitor a different wavelength region of the atmospheric transmission, including regions dominated by the precipitable water absorption and aerosol scattering. We have built a prototype system to test the notion that an atmospheric model derived from a few color indices measurements can be an accurate representation of the true atmospheric transmission. We have measured the atmospheric transmission with both narrowband photometric measurements and spectroscopic measurements; we show that the narrowband imaging approach can predict the changes in the throughput of the atmosphere to better than ˜10% across a broad wavelength range, so as to achieve photometric precision less than 0.01 mag.

  8. Detecting emerging transmissibility of avian influenza virus in human households.

    Directory of Open Access Journals (Sweden)

    Michiel van Boven

    2007-07-01

    Full Text Available Accumulating infections of highly pathogenic H5N1 avian influenza in humans underlines the need to track the ability of these viruses to spread among humans. A human-transmissible avian influenza virus is expected to cause clusters of infections in humans living in close contact. Therefore, epidemiological analysis of infection clusters in human households is of key importance. Infection clusters may arise from transmission events from (i the animal reservoir, (ii humans who were infected by animals (primary human-to-human transmission, or (iii humans who were infected by humans (secondary human-to-human transmission. Here we propose a method of analysing household infection data to detect changes in the transmissibility of avian influenza viruses in humans at an early stage. The method is applied to an outbreak of H7N7 avian influenza virus in The Netherlands that was the cause of more than 30 human-to-human transmission events. The analyses indicate that secondary human-to-human transmission is plausible for the Dutch household infection data. Based on the estimates of the within-household transmission parameters, we evaluate the effectiveness of antiviral prophylaxis, and conclude that it is unlikely that all household infections can be prevented with current antiviral drugs. We discuss the applicability of our method for the detection of emerging human-to-human transmission of avian influenza viruses in particular, and for the analysis of within-household infection data in general.

  9. Price setting in turbulent times

    DEFF Research Database (Denmark)

    Ólafsson, Tjörvi; Pétursdóttir, Ásgerdur; Vignisdóttir, Karen Á.

    extent driven by exchange rate fluctuations than in most other advanced countries. The median Icelandic firm reviews its prices every four months and changes them every six months. The main sources of price rigidity and the most commonly used price setting methods are the same as in most other countries...... prices rather than decreasing costs to restore profit margins after an exchange rate depreciation. They also review their prices more often but nevertheless, surprisingly, have the same price change frequency as the median firm. On the other hand, price review frequency declines and time...

  10. Annotated Answer Set Programming

    OpenAIRE

    Straccia, Umberto

    2005-01-01

    We present Annotated Answer Set Programming, that extends the ex pressive power of disjunctive logic programming with annotation terms, taken from the generalized annotated logic programming framework.

  11. Meningococcal Disease: Causes and Transmission

    Science.gov (United States)

    ... Campaign Podcast: Meningitis Immunization for Adolescents Meningitis Sepsis Causes & Transmission Recommend on Facebook Tweet Share Compartir Causes Meningococcal disease is caused by the bacterium Neisseria ...

  12. EC Transmission Line Materials

    International Nuclear Information System (INIS)

    The purpose of this document is to identify materials acceptable for use in the US ITER Project Office (USIPO)-supplied components for the ITER Electron cyclotron Heating and Current Drive (ECH and CD) transmission lines (TL), PBS-52. The source of material property information for design analysis shall be either the applicable structural code or the ITER Material Properties Handbook. In the case of conflict, the ITER Material Properties Handbook shall take precedence. Materials selection, and use, shall follow the guidelines established in the Materials Assessment Report (MAR). Materials exposed to vacuum shall conform to the ITER Vacuum Handbook. (Ref. 2) Commercial materials shall conform to the applicable standard (e.g., ASTM, JIS, DIN) for the definition of their grade, physical, chemical and electrical properties and related testing. All materials for which a suitable certification from the supplier is not available shall be tested to determine the relevant properties, as part of the procurement. A complete traceability of all the materials including welding materials shall be provided. Halogenated materials (example: insulating materials) shall be forbidden in areas served by the detritiation systems. Exceptions must be approved by the Tritium System and Safety Section Responsible Officers.

  13. EC Transmission Line Materials

    Energy Technology Data Exchange (ETDEWEB)

    Bigelow, Tim S [ORNL

    2012-05-01

    The purpose of this document is to identify materials acceptable for use in the US ITER Project Office (USIPO)-supplied components for the ITER Electron cyclotron Heating and Current Drive (ECH&CD) transmission lines (TL), PBS-52. The source of material property information for design analysis shall be either the applicable structural code or the ITER Material Properties Handbook. In the case of conflict, the ITER Material Properties Handbook shall take precedence. Materials selection, and use, shall follow the guidelines established in the Materials Assessment Report (MAR). Materials exposed to vacuum shall conform to the ITER Vacuum Handbook. [Ref. 2] Commercial materials shall conform to the applicable standard (e.g., ASTM, JIS, DIN) for the definition of their grade, physical, chemical and electrical properties and related testing. All materials for which a suitable certification from the supplier is not available shall be tested to determine the relevant properties, as part of the procurement. A complete traceability of all the materials including welding materials shall be provided. Halogenated materials (example: insulating materials) shall be forbidden in areas served by the detritiation systems. Exceptions must be approved by the Tritium System and Safety Section Responsible Officers.

  14. Transmission of digital data

    Science.gov (United States)

    Showen, Charles R.

    1971-01-01

    The Geological Survey, Water Resources Division, established a pilot project to evaluate equipment that would transmit date recorded on 16-channel paper tapes over voice-grade telephone lines from field offices to the Washington, D.C., Automatic Data Processing Unit (A.D.P. Unit). Such equipment would allow computer-processed data for current-purpose hydrologic data stations to be made available in a more timely manner. The specifications for the equipment were prepared in March 1970; invitations to bid were solicited, a contract was awarded and the equipment was delivered in November 1970. The equipment included two reader/transmitter units, and one receiver/recorder unit. The reader/transmitter units transmit manually entered fixed information, i.e. station number, beginning date and time, and ending date and time, and photoelectrically read and transmit the 16-channel paper tape data. The receiver/recorder unit records the transmitted information on IBM-compatible magnetic tape. This report summarizes the information gained from a year of pilot operation of the equipment, with and without a computer terminal at the field level, and makes recommendations for establishing a data-transmission system in the Water Resources Division.

  15. Descriptive set theory

    CERN Document Server

    Moschovakis, YN

    1987-01-01

    Now available in paperback, this monograph is a self-contained exposition of the main results and methods of descriptive set theory. It develops all the necessary background material from logic and recursion theory, and treats both classical descriptive set theory and the effective theory developed by logicians.

  16. Neutrosophic Crisp Set Theory

    OpenAIRE

    A. A. Salama; Florentin Smarandache

    2014-01-01

    The purpose of this paper is to introduce new types of neutrosophic crisp sets with three types 1, 2, 3. After given the fundamental definitions and operations, we obtain several properties, and discussed the relationship between neutrosophic crisp sets and others. Also, we introduce and study the neutrosophic crisp point and neutrosophic crisp relations. Possible applications to database are touched upon.

  17. China Sets Resources Strategy

    Institute of Scientific and Technical Information of China (English)

    LiMin

    2003-01-01

    All mineral mining in China now has a set road to follow, and straying off its path will attract severe penalties. The country's first-round programs for provincial mineral resources exploitation took effect in mid-January, setting output goals and designating mining regions.

  18. Haar meager sets revisited

    Czech Academy of Sciences Publication Activity Database

    Doležal, Martin; Rmoutil, M.; Vejnar, B.; Vlasák, V.

    2016-01-01

    Roč. 440, č. 2 (2016), s. 922-939. ISSN 0022-247X Institutional support: RVO:67985840 Keywords : Haar meager set * Haar null set * Polish group Impact factor: 1.120, year: 2014 http://www. science direct.com/ science /article/pii/S0022247X1600305X

  19. Setting goals in psychotherapy

    DEFF Research Database (Denmark)

    Emiliussen, Jakob; Wagoner, Brady

    2013-01-01

    The present study is concerned with the ethical dilemmas of setting goals in therapy. The main questions that it aims to answer are: who is to set the goals for therapy and who is to decide when they have been reached? The study is based on four semi-­‐structured, phenomenological interviews with...

  20. The Proportional Set

    Science.gov (United States)

    Vilella, Cori

    2009-09-01

    In this paper we deal with asymmetric TU-cooperative games where every player has an initial positive weight. In this framework we introduce a new set-solution concept, the proportional set, which is based on equity considerations. We provide an algorithm to locate the proportional set inspired by Dutta and Ray [3] algorithm's to find the egalitarian solution in a convex game, and we prove that, for superadditive games and for any weights of the players, the proportional set is included in the equity core, see [9]. For convex games the proportional set has only one element and it is in the core of the game. In the particular case of convex games where all players have the same weight the proportional algorithm coincides with the one given by Dutta and Ray [3] and the solution is the egalitarian solution.

  1. Regulatory issues in merchant transmission investment

    International Nuclear Information System (INIS)

    Merchant investment in electricity transmission networks (MTI) is now legally allowed. Predominantly driven by the fear of underinvestment, regulators examine this possibility and given that MTI is a possibility, the regulators face a new set of questions. This paper raises and examines regulatory questions especially from a European institutional framework. The regulatory issues concern the competition effect, the ownership, access regime and the must-offer provision. The paper argues to leave light-handed unregulated MTI light handed and refrain from additional measures. In most cases, it is justified to refrain from sector-specific arrangements because competition,law, if necessary at all, will suffice. However, details matter. (author)

  2. HVDC power transmission technology assessment

    Energy Technology Data Exchange (ETDEWEB)

    Hauth, R.L.; Tatro, P.J.; Railing, B.D. [New England Power Service Co., Westborough, MA (United States); Johnson, B.K.; Stewart, J.R. [Power Technologies, Inc., Schenectady, NY (United States); Fink, J.L.

    1997-04-01

    The purpose of this study was to develop an assessment of the national utility system`s needs for electric transmission during the period 1995-2020 that could be met by future reduced-cost HVDC systems. The assessment was to include an economic evaluation of HVDC as a means for meeting those needs as well as a comparison with competing technologies such as ac transmission with and without Flexible AC Transmission System (FACTS) controllers. The role of force commutated dc converters was to be assumed where appropriate. The assessment begins by identifying the general needs for transmission in the U.S. in the context of a future deregulated power industry. The possible roles for direct current transmission are then postulated in terms of representative scenarios. A few of the scenarios are illustrated with the help of actual U.S. system examples. non-traditional applications as well as traditional applications such as long lines and asynchronous interconnections are discussed. The classical ``break-even distance`` concept for comparing HVDC and ac lines is used to assess the selected scenarios. The impact of reduced-cost converters is reflected in terms of the break-even distance. This report presents a comprehensive review of the functional benefits of HVDC transmission and updated cost data for both ac and dc system components. It also provides some provocative thoughts on how direct current transmission might be applied to better utilize and expand our nation`s increasingly stressed transmission assets.

  3. The concept of the set to objectification of LLLT exposure

    Science.gov (United States)

    Gryko, Lukasz; Gilewski, Marian; Szymanska, Justyna; Zajac, Andrzej; Rosc, Danuta

    2013-01-01

    In this article authors present the developed optoelectronic set for controlled, repeatable exposure by electromagnetic radiation of biological structures in the spectral band of tissue transmission window 600-1000 nm. The set allows for an objective selection and control of exposure parameters and comparison of results for variable energetic, spectral and polarization parameters of radiation beam. Possibility of objective diagnostics of tissue state during laser treatment was provided in the presented optoelectronic set.

  4. Gas transmission : a paradigm shift

    International Nuclear Information System (INIS)

    The evolution of energy markets in North America was discussed. The investment opportunities that are possible in a deregulated energy market, be it in production or in the generation of energy commodities, in the development of midstream infrastructure, or in the provision of energy services, were outlined. Deregulation of crude oil, natural gas and electricity has resulted in significant changes in the structure of energy markets and the way in which customers are served. One of the advantages of competition regarding power generation is that it has turned energy into a commodity which has resulted in greater customer choice and efficiency. As one example of midstream infrastructure development, the Alliance Pipeline project was described. This project was conceived as a means to enhance the value of western Canadian natural gas. The 1,900 mile pipeline will run from British Columbia, through Alberta into Chicago where it will interconnect with the North American gas transmission grid. The pipeline is an efficient means of transporting energy from Western Canada to North American markets, and Alliance, as a lowest cost transporter, will continue to put pressure on the traditional infrastructure to become even more competitive at the margin. As such, Alliance represents a paradigm shift in energy transportation, and serves as an excellent example of the type of investment opportunity that a deregulated market can provide. It was suggested that innovation and competition in a deregulated North American energy market will continue to increase. As electricity is deregulated, the energy market will respond more quickly to changes in supply and demand than it did in the past, in an effort to satisfy the needs of investors and customers. This will provide increased opportunities for restructuring and further competition

  5. Simulation of worms transmission in computer network based on SIRS fuzzy epidemic model

    Science.gov (United States)

    Darti, I.; Suryanto, A.; Yustianingsih, M.

    2015-03-01

    In this paper we study numerically the behavior of worms transmission in a computer network. The model of worms transmission is derived by modifying a SIRS epidemic model. In this case, we consider that the transmission rate, recovery rate and rate of susceptible after recovery follows fuzzy membership functions, rather than constants. To study the transmission of worms in a computer network, we solve the model using the fourth order Runge-Kutta method. Our numerical results show that the fuzzy transmission rate and fuzzy recovery rate may lead to a changing of basic reproduction number which therefore also changes the stability properties of equilibrium points.

  6. Research on target information optics communications transmission characteristic and performance in multi-screens testing system

    Science.gov (United States)

    Li, Hanshan

    2016-04-01

    To enhance the stability and reliability of multi-screens testing system, this paper studies multi-screens target optical information transmission link properties and performance in long-distance, sets up the discrete multi-tone modulation transmission model based on geometric model of laser multi-screens testing system and visible light information communication principle; analyzes the electro-optic and photoelectric conversion function of sender and receiver in target optical information communication system; researches target information transmission performance and transfer function of the generalized visible-light communication channel; found optical information communication transmission link light intensity space distribution model and distribution function; derives the SNR model of information transmission communication system. Through the calculation and experiment analysis, the results show that the transmission error rate increases with the increment of transmission rate in a certain channel modulation depth; when selecting the appropriate transmission rate, the bit error rate reach 0.01.

  7. Energy Transmission and Infrastructure

    Energy Technology Data Exchange (ETDEWEB)

    Mathison, Jane

    2012-12-31

    The objective of Energy Transmission and Infrastructure Northern Ohio (OH) was to lay the conceptual and analytical foundation for an energy economy in northern Ohio that will: • improve the efficiency with which energy is used in the residential, commercial, industrial, agricultural, and transportation sectors for Oberlin, Ohio as a district-wide model for Congressional District OH-09; • identify the potential to deploy wind and solar technologies and the most effective configuration for the regional energy system (i.e., the ratio of distributed or centralized power generation); • analyze the potential within the district to utilize farm wastes to produce biofuels; • enhance long-term energy security by identifying ways to deploy local resources and building Ohio-based enterprises; • identify the policy, regulatory, and financial barriers impeding development of a new energy system; and • improve energy infrastructure within Congressional District OH-09. This objective of laying the foundation for a renewable energy system in Ohio was achieved through four primary areas of activity: 1. district-wide energy infrastructure assessments and alternative-energy transmission studies; 2. energy infrastructure improvement projects undertaken by American Municipal Power (AMP) affiliates in the northern Ohio communities of Elmore, Oak Harbor, and Wellington; 3. Oberlin, OH-area energy assessment initiatives; and 4. a district-wide conference held in September 2011 to disseminate year-one findings. The grant supported 17 research studies by leading energy, policy, and financial specialists, including studies on: current energy use in the district and the Oberlin area; regional potential for energy generation from renewable sources such as solar power, wind, and farm-waste; energy and transportation strategies for transitioning the City of Oberlin entirely to renewable resources and considering pedestrians, bicyclists, and public transportation as well as drivers

  8. Set theory essentials

    CERN Document Server

    Milewski, Emil G

    2012-01-01

    REA's Essentials provide quick and easy access to critical information in a variety of different fields, ranging from the most basic to the most advanced. As its name implies, these concise, comprehensive study guides summarize the essentials of the field covered. Essentials are helpful when preparing for exams, doing homework and will remain a lasting reference source for students, teachers, and professionals. Set Theory includes elementary logic, sets, relations, functions, denumerable and non-denumerable sets, cardinal numbers, Cantor's theorem, axiom of choice, and order relations.

  9. Setting the minimum wage

    OpenAIRE

    Boeri, Tito

    2009-01-01

    The process leading to the setting of the minimum wage so far has been fairly overlooked by economists. This paper suggests that this is a serious limitation as the setting regime contributes to explain cross-country variation in the fine-tuning of the minimum wage, hence in the way in which the trade-off between reducing poverty among working people and shutting down low productivity jobs is addressed. There are two common ways of setting national minimum wages: they are either government le...

  10. Basic set theory

    CERN Document Server

    Levy, Azriel

    2002-01-01

    An advanced-level treatment of the basics of set theory, this text offers students a firm foundation, stopping just short of the areas employing model-theoretic methods. Geared toward upper-level undergraduate and graduate students, it consists of two parts: the first covers pure set theory, including the basic motions, order and well-foundedness, cardinal numbers, the ordinals, and the axiom of choice and some of it consequences; the second deals with applications and advanced topics such as point set topology, real spaces, Boolean algebras, and infinite combinatorics and large cardinals. An

  11. The Model Confidence Set

    DEFF Research Database (Denmark)

    Hansen, Peter Reinhard; Lunde, Asger; Nason, James M.

    The paper introduces the model confidence set (MCS) and applies it to the selection of models. A MCS is a set of models that is constructed such that it will contain the best model with a given level of confidence. The MCS is in this sense analogous to a confidence interval for a parameter. The MCS......, beyond the comparison of models. We apply the MCS procedure to two empirical problems. First, we revisit the inflation forecasting problem posed by Stock and Watson (1999), and compute the MCS for their set of inflation forecasts. Second, we compare a number of Taylor rule regressions and determine the...

  12. Symmetry Adapted Basis Sets

    DEFF Research Database (Denmark)

    Avery, John Scales; Rettrup, Sten; Avery, James Emil

    In theoretical physics, theoretical chemistry and engineering, one often wishes to solve partial differential equations subject to a set of boundary conditions. This gives rise to eigenvalue problems of which some solutions may be very difficult to find. For example, the problem of finding...... such problems can be much reduced by making use of symmetry-adapted basis functions. The conventional method for generating symmetry-adapted basis sets is through the application of group theory, but this can be difficult. This book describes an easier method for generating symmetry-adapted basis sets...

  13. Regional Transmission Projects: Finding Solutions

    Energy Technology Data Exchange (ETDEWEB)

    The Keystone Center

    2005-06-15

    The Keystone Center convened and facilitated a year-long Dialogue on "Regional Transmission Projects: Finding Solutions" to develop recommendations that will help address the difficult and contentious issues related to expansions of regional electric transmission systems that are needed for reliable and economic transmission of power within and across regions. This effort brought together a cross-section of affected stakeholders and thought leaders to address the problem with the collective wisdom of their experience and interests. Transmission owners sat at the table with consumer advocates and environmental organizations. Representatives from regional transmission organizations exchanged ideas with state and federal regulators. Generation developers explored common interests with public power suppliers. Together, the Dialogue participants developed consensus solutions about how to begin unraveling some of the more intractable issues surrounding identification of need, allocation of costs, and reaching consensus on siting issues that can frustrate the development of regional transmission infrastructure. The recommendations fall into three broad categories: 1. Recommendations on appropriate institutional arrangements and processes for achieving regional consensus on the need for new or expanded transmission infrastructure 2. Recommendations on the process for siting of transmission lines 3. Recommendations on the tools needed to support regional planning, cost allocation, and siting efforts. List of Dialogue participants: List of Dialogue Participants: American Electric Power American Transmission Company American Wind Energy Association California ISO Calpine Corporation Cinergy Edison Electric Institute Environmental Defense Federal Energy Regulatory Commission Great River Energy International Transmission Company ISO-New England Iowa Public Utility Board Kanner & Associates Midwest ISO National Association of Regulatory Utility Commissioners National Association

  14. HEDIS Limited Data Set

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Healthcare Effectiveness Data and Information Set (HEDIS) is a tool used by more than 90 percent of Americas health plans to measure performance on important...

  15. Landslides, Set 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This set of slides graphically illustrates the potential danger that major earthquakes pose to school structures and to the children and adults who happen to be...

  16. Lebesgue Sets Immeasurable Existence

    Directory of Open Access Journals (Sweden)

    Diana Marginean Petrovai

    2012-12-01

    Full Text Available It is well known that the notion of measure and integral were released early enough in close connection with practical problems of measuring of geometric figures. Notion of measure was outlined in the early 20th century through H. Lebesgue’s research, founder of the modern theory of measure and integral. It was developed concurrently a technique of integration of functions. Gradually it was formed a specific area todaycalled the measure and integral theory. Essential contributions to building this theory was made by a large number of mathematicians: C. Carathodory, J. Radon, O. Nikodym, S. Bochner, J. Pettis, P. Halmos and many others. In the following we present several abstract sets, classes of sets. There exists the sets which are not Lebesgue measurable and the sets which are Lebesgue measurable but are not Borel measurable. Hence B ⊂ L ⊂ P(X.

  17. Transmission of Electric Energy Along Long Lines

    Directory of Open Access Journals (Sweden)

    Berzan V.P.

    2009-08-01

    Full Text Available Transmission of electric energy along long lines is examined and characteristics of the change of capacities at the beginning and at the end of a line are submitted: factor of capacity, efficiency of a transmission line, currents depending on length, parameters of a line and parameters of loading. Influence of losses upon the dynamics of instant values of voltages and currents in the opened and short-circuited long lines is investigated and effects of nonlinearity in such chains are revealed at a power supply from a sinusoidal source of voltage. It is shown, that the method of complex amplitudes is not always applicable for the calculation of modes in long lines.

  18. The Transmission of Chinese Medicine in Australia

    Directory of Open Access Journals (Sweden)

    Mary Garvey

    2011-09-01

    Full Text Available The paper explores some of the issues concerning the transmission of Chinese medicine in Australia, its practitioner training and the future of Chinese medicine as a distinct medical discipline in the Australian context. In China over the last century Chinese medicine was overhauled in order to align it with the biomedical perspective prevalent in the West. These changes, in turn, had important consequences for the transmission of CM in Australia and the West. But while the biomedicalisation of CM has offered the path of least resistance, it has also lead to unworkable simplifications and methodological failures. The paper thus argues for a renewed access to the tradition’s primary sources in order to ally the distinctive features and methods of traditional practice with biomedicine, as an alternative to an outright integration into biomedical practice.

  19. MONETARY POLICY TRANSMISSION MECHANISM IN EMERGING COUNTRIES

    Directory of Open Access Journals (Sweden)

    Andreea ROŞOIU

    2013-06-01

    Full Text Available The transmission channels of monetary policy are used by central banks to accomplish the main objective of price stability in the context of sustainable economic growth. The importance of interest rate and exchange rate channels for the emerging countries Romania, Poland, Czech Republic and Hungary is analyzed by using Bayesian VAR approach with Diffuse priors over 1998Q1-2012Q3. Main result of the empirical study is that both channels are effective for the monetary policy transmission mechanism in Hungary and Czech Republic. In Romania and Poland they do not exhibit puzzles, but the impact of the macroeconomic variables is not very significant and shows very high volatility. In the context of monetary integration, exchange rate channel will become irrelevant when these countries adopt Euro currency. This change will lead instead to a powerful interest rate channel.

  20. Finite Sets and Counting

    OpenAIRE

    Preston, Chris

    2008-01-01

    We start by presenting a theory of finite sets using the approach which is essentially that taken by Whitehead and Russell in Principia Mathematica}, and which does not involve the natural numbers (or any other infinite set). This theory is then applied to prove results about structures which, like the natural numbers, satisfy the principle of mathematical induction, but do not necessarily satisfy the remaining Peano axioms.