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Sample records for change interval traffic signal cycle

  1. Comparison of Two Methods of Traffic Signal Design Cycle

    Directory of Open Access Journals (Sweden)

    María Liliana Alba Menéndez

    2013-02-01

    Full Text Available To satisfy the traffic demand in intersections, with safety and efficiency it is common to use a signallike control device, such that the right of using the common space of the intersections is assignedalternatively to the currents of such traffic flow that they cross. In Cuba, for the calculation of the cyclelength and the phases of the signal the Method of Poisson is used, based on the probability ofrandom arrivals of vehicles to the access point, developed in the 50th century. Presently many countriesuse the Method developed by Webster in England during 60th century, based on empiric observationsthen and unto today has proven effective, where an optimal cycle length is calculated, that is minimumdelays and better levels of service.In this study several intersections in Havana with high levels ofcomplexity were studied, the cycle length and the intervals of green were calculated by each method,the parameters that define the quality of the operation were determined in each method. The resultwill be vital in the strategic planning as see fit the National Centre of Traffic Engineering in thedesigning of traffic lights, with efficiency in road traffic.

  2. Distributed traffic signal control using fuzzy logic

    Science.gov (United States)

    Chiu, Stephen

    1992-01-01

    We present a distributed approach to traffic signal control, where the signal timing parameters at a given intersection are adjusted as functions of the local traffic condition and of the signal timing parameters at adjacent intersections. Thus, the signal timing parameters evolve dynamically using only local information to improve traffic flow. This distributed approach provides for a fault-tolerant, highly responsive traffic management system. The signal timing at an intersection is defined by three parameters: cycle time, phase split, and offset. We use fuzzy decision rules to adjust these three parameters based only on local information. The amount of change in the timing parameters during each cycle is limited to a small fraction of the current parameters to ensure smooth transition. We show the effectiveness of this method through simulation of the traffic flow in a network of controlled intersections.

  3. Traffic Signal Using Smart Agent System

    OpenAIRE

    Cheonshik Kim; You S. Hong

    2008-01-01

    In this research, we propose an electro-sensitive traffic light using the smart agent algorithm to reduce traffic congestion and traffic accidents. The multi-agent system approach can provide a new and preferable solution. The proposed method adaptively controls the cycle of traffic signals even though the traffic volume varies. Consequently, we reduce the car waiting time and start-up delay time using fuzzy control of feedback data. In particular, we have designed and implemented a system to...

  4. Traffic Signal Using Smart Agent System

    Directory of Open Access Journals (Sweden)

    Cheonshik Kim

    2008-01-01

    Full Text Available In this research, we propose an electro-sensitive traffic light using the smart agent algorithm to reduce traffic congestion and traffic accidents. The multi-agent system approach can provide a new and preferable solution. The proposed method adaptively controls the cycle of traffic signals even though the traffic volume varies. Consequently, we reduce the car waiting time and start-up delay time using fuzzy control of feedback data. In particular, we have designed and implemented a system to create optimum traffic signals in congested conditions. The effectiveness of this method was shown through simulation of multiple intersections.

  5. System and method for traffic signal timing estimation

    KAUST Repository

    Dumazert, Julien

    2015-12-30

    A method and system for estimating traffic signals. The method and system can include constructing trajectories of probe vehicles from GPS data emitted by the probe vehicles, estimating traffic signal cycles, combining the estimates, and computing the traffic signal timing by maximizing a scoring function based on the estimates. Estimating traffic signal cycles can be based on transition times of the probe vehicles starting after a traffic signal turns green.

  6. Muscle oxygen changes following Sprint Interval Cycling training in elite field hockey players.

    Directory of Open Access Journals (Sweden)

    Ben Jones

    Full Text Available This study examined the effects of Sprint Interval Cycling (SIT on muscle oxygenation kinetics and performance during the 30-15 intermittent fitness test (IFT. Twenty-five women hockey players of Olympic standard were randomly selected into an experimental group (EXP and a control group (CON. The EXP group performed six additional SIT sessions over six weeks in addition to their normal training program. To explore the potential training-induced change, EXP subjects additionally completed 5 x 30s maximal intensity cycle testing before and after training. During these tests near-infrared spectroscopy (NIRS measured parameters; oxyhaemoglobin + oxymyoglobin (HbO2+ MbO2, tissue deoxyhaemoglobin + deoxymyoglobin (HHb+HMb, total tissue haemoglobin (tHb and tissue oxygenation (TSI % were taken. In the EXP group (5.34 ± 0.14 to 5.50 ± 0.14 m.s(-1 but not the CON group (pre = 5.37 ± 0.27 to 5.39 ± 0.30 m.s(-1 significant changes were seen in the 30-15 IFT performance. EXP group also displayed significant post-training increases during the sprint cycling: ΔTSI (-7.59 ± 0.91 to -12.16 ± 2.70%; ΔHHb+HMb (35.68 ± 6.67 to 69.44 ± 26.48 μM.cm; and ΔHbO2+ MbO2 (-74.29 ± 13.82 to -109.36 ± 22.61 μM.cm. No significant differences were seen in ΔtHb (-45.81 ± 15.23 to -42.93 ± 16.24. NIRS is able to detect positive peripheral muscle oxygenation changes when used during a SIT protocol which has been shown to be an effective training modality within elite athletes.

  7. Scaling and memory in recurrence intervals of Internet traffic

    CERN Document Server

    Cai, Shi-Min; Zhou, Tao; Gu, Jun; Zhou, Pei-Ling

    2009-01-01

    By studying the statistics of recurrence intervals, $\\tau$, between volatilities of Internet traffic rate changes exceeding a certain threshold $q$, we find that the probability distribution functions, $P_{q}(\\tau)$, for both byte and packet flows, show scaling property as $P_{q}(\\tau)=\\frac{1}{\\overline{\\tau}}f(\\frac{\\tau}{\\overline{\\tau}})$. The scaling functions for both byte and packet flows obeys the same stretching exponential form, $f(x)=A\\texttt{exp}(-Bx^{\\beta})$, with $\\beta \\approx 0.45$. In addition, we detect a strong memory effect that a short (or long) recurrence interval tends to be followed by another short (or long) one. The detrended fluctuation analysis further demonstrates the presence of long-term correlation in recurrence intervals.

  8. Autonomous Traffic Signal Control Model with Neural Network Analogy

    CERN Document Server

    Ohira, T

    1997-01-01

    We propose here an autonomous traffic signal control model based on analogy with neural networks. In this model, the length of cycle time period of traffic lights at each signal is autonomously adapted. We find a self-organizing collective behavior of such a model through simulation on a one-dimensional lattice model road: traffic congestion is greatly diffused when traffic signals have such autonomous adaptability with suitably tuned parameters. We also find that effectiveness of the system emerges through interactions between units and shows a threshold transition as a function of proportion of adaptive signals in the model.

  9. Study of Truck Driver Behavior at Onset of Yellow Traffic Signal Indication for the Design of Yellow Times

    OpenAIRE

    Bryant, Craig William

    2014-01-01

    Traffic signal violations by drivers are a leading contributor to crashes at signalized intersections. The yellow indication is used to inform drivers of an upcoming change in the status of the traffic signal. Yellow-interval durations are currently calculated to provide dilemma zone protection for passenger cars. Due to differences in vehicle characteristics and driver characteristics, heavy trucks such as tractor-trailers behave differently at the onset of a yellow-indication. The resea...

  10. Traffic Signals in Motorcycle Dependent Cities

    OpenAIRE

    Do, Quoc Cuong

    2009-01-01

    Traffic signal control was first invented in 1868 in Great Britain. Then, it has quickly spread across many other countries, what are now usually developed countries. Therefore, during a long history of development, traffic signals usually have been dealing with traffic in which four-wheel vehicles play an important role in motorised traffic. However, as a result of an unequal development among countries, many Motorcycle Dependent Cities (MDCs) nowadays still exist mostly in the developing co...

  11. Light signals for road traffic control.

    OpenAIRE

    Schreuder, D.A.

    1981-01-01

    Signals for road traffic control are a major constituent of the modern traffic scene, particularly in built-up areas. A vast amount of research has been executed in the last two decennia, resulting in a fairly generally accepted view on what the requirements for effective traffic lights are. For the French translation see B 19780

  12. [Changes in autonomic nerve function during the normal menstrual cycle measured by the coefficient of variation of R-R intervals].

    Science.gov (United States)

    Kondo, M; Hirano, T; Okamura, Y

    1989-05-01

    The purpose of this study was to determine if there is a change in autonomic nerve function during the menstrual cycle. The subjects were 20 females (average age 26.1 years +/- 4.6) with a normal menstrual cycle. The coefficient of variation of R-R intervals (CV R.R) was measured to investigate autonomic function in the menstrual, follicular, ovulatory, luteal, and premenstrual phases. Average CV R-R for all phases was 5.2 +/- 1.9%. And the CV R-R tended to be lower in those in their 30s than in those in their 20s. And no noticeable difference was seen in the CV R-R among the 5 phases of the menstrual cycle. On the other hand, the CV R-R of 11 females with premenstrual syndrome was low in the ovulatory, luteal and premenstrual phases. These results, which provide basic data for clinical use, suggest the following. (1) The age of subjects should be taken into consideration. (2) Changes in the CV R-R during the menstrual cycle are negligible. (3) However, in those showing symptoms associated with the menstrual cycle such as premenstrual syndrome, changes during the menstrual cycle should be taken into account. At the same time psychological changes in the subjects were evaluated by the following tests: Cornell Medical Index, Taylor's manifest anxiety scale, and Zung's self-rating depression scale. The results of these tests did not vary significantly during the menstrual cycle.

  13. A Two-Stage Fuzzy Logic Control Method of Traffic Signal Based on Traffic Urgency Degree

    OpenAIRE

    Yan Ge

    2014-01-01

    City intersection traffic signal control is an important method to improve the efficiency of road network and alleviate traffic congestion. This paper researches traffic signal fuzzy control method on a single intersection. A two-stage traffic signal control method based on traffic urgency degree is proposed according to two-stage fuzzy inference on single intersection. At the first stage, calculate traffic urgency degree for all red phases using traffic urgency evaluation module and select t...

  14. Traffic Matrix Reloaded: Impact of Routing Changes

    OpenAIRE

    Teixeira, Renata; Duffield, Nick; Rexford, Jennifer; Roughan, Matthew

    2005-01-01

    International audience A traffic matrix represents the load from each ingress point to each egress point in an IP network. Although networks are engineered to tolerate some variation in the traffic matrix, large changes can lead to congested links and poor performance. The variations in the traffic matrix are caused by statistical fluc-tuations in the traffic entering the network and shifts in where the traffic leaves the network. For an accurate view of how the traffic matrix evolves over...

  15. Modelling of urban traffic networkof signalized intersections

    OpenAIRE

    Ocran, Abena Kwantwiwaa

    2013-01-01

    This report presents how traffic network of signalized intersection in a chosen urban area called Tema is synchronized. Using a modular approach, two different types of traffic intersection commonly found in an urban area were modelled i.e. a simple intersection and a complex intersection. A direct road, even though not an intersection, was also included in the modelling because it’s commonly found in an urban area plus it connects any two intersections. Each of these scenarios was modelled u...

  16. Three-phase theory of city traffic: Moving synchronized flow patterns in under-saturated city traffic at signals

    Science.gov (United States)

    Kerner, Boris S.

    2014-03-01

    Three-phase traffic flow theory of city traffic has been developed. Based on simulations of a stochastic microscopic traffic flow model, features of moving synchronized flow patterns (MSP) have been studied, which are responsible for a random time-delayed breakdown of a green-wave (GW) organized in a city. A possibility of GW control leading to the prevention of GW breakdown has been demonstrated. A diagram of traffic breakdown in under-saturated traffic (transition from under- to over-saturated city traffic) at the signal has been found; the diagram presents regions of the average arrival flow rate, within which traffic breakdown can occur, in dependence of parameters of the time-function of the arrival flow rate or/and signal parameters. Physical reasons for a crucial difference between results of classical theory of city traffic and three-phase theory are explained. In particular, we have found that under-saturated traffic at the signal can exist during a long time interval, when the average arrival flow rate is larger than the capacity of the classical theory; the classical capacity is equal to a minimum capacity in three-phase theory. Within a range of the average arrival flow rate between the minimum and maximum signal capacities, under-saturated traffic is in a metastable state with respect to traffic breakdown. We have distinguished the following possible causes for the metastability of under-saturated traffic: (i) The arrival flow rate during the green phase is larger than the saturation flow rate. (ii) The length of the upstream front of a queue at the signal is a finite value. (iii) The outflow rate from a MSP (the rate of MSP discharge) is larger than the saturation flow rate.

  17. Spectral representation of the annual cycle in the climate change signal

    OpenAIRE

    T. Bosshard; S. Kotlarski; Ewen, T.; Schär, C.

    2011-01-01

    The annual cycle of temperature and precipitation changes as projected by climate models is of fundamental interest in climate impact studies. Its estimation, however, is impaired by natural variability. Using a simple form of the delta change method, we show that on regional scales relevant for hydrological impact models, the projected changes in the annual cycle are prone to sampling artefacts. For precipitation at station locations, these artefacts may have amplitudes that are comparable t...

  18. FL-FN-MOGA Based Traffic Signal Control

    Institute of Scientific and Technical Information of China (English)

    魏武; 张毅

    2003-01-01

    In this paper, a traffic signal control method based on fuzzy logic (FL), fuzzy-neuro (FN) and multi-objective genetic algorithms (MOGA) for an isolated four-approach intersection with through and left-turning movements is presented. This method has an adaptive signal timing ability, and can make adjustments to signal timing in response to observed changes. The "urgency degree" term, which can describe the different user's demand for green time is used in decision-making by which strategy of signal timing can be determined. Using a fuzzy logic controller, we can determine whether to extend or terminate the current signal phase and select the sequences of phases. In this paper, a method based on fuzzy-neuro can be used to predict traffic parameters used in fuzzy logic controller. The feasibility of using a multi-objective genetic algorithm (MOGA) to find a group of optimizing sets of parameters for fuzzy logic controller depending on different objects is also demonstrated. Simulation results show that the proposed methed is effecfive to adjust the signal timing in response to changing traffic conditions on a real-time basis, and the controller can produce lower vehicle delays and percentage of stopped vehicles than a traffic-actuated controller.

  19. Urban Intersection Traffic Signal Control Based on Fuzzy Logic

    Institute of Scientific and Technical Information of China (English)

    魏武; 张毅; 张佐; 宋靖雁

    2002-01-01

    This paper presents a fuzzy logic adaptive traffic signal control method for an isolated four-approach intersection with through and left-turning movements. In the proposed method, the fuzzy logic controller can make adjustments to signal timing in response to observed changes. The "urgency degree" term that can describe different user's demands for a green light is used in the fuzzy logic decision-making. In addition, a three-level fuzzy controller model decides whether to extend or terminate the current signal phase and the sequence of phases. Simulation results show that the fuzzy controller can adjust its signal timing in response to changing traffic conditions on a real-time basis and that the proposed fuzzy logic controller leads to less vehicle delays and a lower percentage of stopped vehicles.

  20. Capacity Reliability of Signalized Intersections with Mixed Traffic Conditions

    Institute of Scientific and Technical Information of China (English)

    CHEN Xiaoming; SHAO Chunfu; LI Da; DONG Chunjiao

    2009-01-01

    The reliability of capacity of signalized intersections in mixed traffic conditions involving vehicles, bicycles, and pedestrians was investigated to complete the conventional, deterministic capacity calculations. Simulations using VISSIM provided estimates of capacity distributions, and demonstrated the effects of the analysis intervals on the distributions. With the random vehicle arrivals taken into account, a capacity reli-ability assessment method was given as a function. Assessments were also performed regarding the effects of the conflicting pedestrian and bicycle volumes on capacity reliability. The simulation indicates that the pe-destrians and bicycles result in greater random fluctuations of exclusive tuming lane capacities, but have less effect on the variability of shared lane capacities. Normal distributions can be used to model the capaci-ties for intervals not less than 10 min. At higher vehicular volumes, the capacity reliability is more sensitive to the mean and standard deviation of the pedestrian and bicycle volumes.

  1. Traffic breakdown at a signal: classical theory versus the three-phase theory of city traffic

    International Nuclear Information System (INIS)

    Physical reasons for a crucial difference between the results of a three-phase theory developed recently (Kerner 2011 Phys. Rev. E 84 045102(R); 2013 Europhys. Lett. 102 28010; 2014 Physica A 397 76) and the classical theory are explained. Microscopic characteristics of traffic passing a traffic signal during the green signal phase and their dependence on the duration of the green phase have been found. It turns out that a moving synchronized flow pattern (MSP), which occurs in under-saturated traffic at the signal, causes ‘compression’ of traffic flow: the rate of MSP discharge can be considerably larger than the saturation flow rate of the classical traffic theory of city traffic. This leads to a considerably larger rate of traffic passing the signal in comparison with the saturation flow rate. This effect together with traffic behavior at the upstream queue front explains the metastability of under-saturated traffic with respect to a random time-delayed traffic breakdown. (paper)

  2. Traffic breakdown at a signal: classical theory versus the three-phase theory of city traffic

    Science.gov (United States)

    Kerner, Boris S.; Klenov, Sergey L.; Schreckenberg, Michael

    2014-03-01

    Physical reasons for a crucial difference between the results of a three-phase theory developed recently (Kerner 2011 Phys. Rev. E 84 045102(R); 2013 Europhys. Lett. 102 28010; 2014 Physica A 397 76) and the classical theory are explained. Microscopic characteristics of traffic passing a traffic signal during the green signal phase and their dependence on the duration of the green phase have been found. It turns out that a moving synchronized flow pattern (MSP), which occurs in under-saturated traffic at the signal, causes ‘compression’ of traffic flow: the rate of MSP discharge can be considerably larger than the saturation flow rate of the classical traffic theory of city traffic. This leads to a considerably larger rate of traffic passing the signal in comparison with the saturation flow rate. This effect together with traffic behavior at the upstream queue front explains the metastability of under-saturated traffic with respect to a random time-delayed traffic breakdown.

  3. Traffic signals - alternative method for emissions reduction; Liikennevaloillako paeaestoet alas

    Energy Technology Data Exchange (ETDEWEB)

    Niittymaeki, J. [Helsinki Univ. of Technology, Espoo (Finland)

    2001-07-01

    Traffic signalling is a process, which adapts to the prevailing traffic. The objective of traffic signalling is to direct traffic as safely as possible through a road junction. Other objectives are to maximize the road capacity, to clarify the traffic, and to effect the selection of routs. The target of design and timing of traffic signalling is to minimize the delays of the traffic. However, traffic signalling increases the emissions and fuel consumption. Traditionally the traffic adaptive control has been arranged on the basis of the extension principle, which means the extension of the green light as long as there is demand for the signal, however, only to a set maximum time. In practice the systems seeks an adequate distance in the traffic for cutting off the green light. New methods, such as mathematical optimization, fuzzy logic, neural networks and generic algorithms have been included traffic signalling. These new methods have proven to be 10-20% more efficient than the old ones. Results of the researches have shown that it is possible to achieve significant savings in social economy, including savings in fuels consumption and environmental impacts of the traffic, by development/renovation of traffic signalling. This article reviews the studies carried out in Finland on traffic signalling. A typical driving process through a signalized road junction: deceleration, idle running, acceleration and steady driving. The emissions of these phases differ from each other. Gasoline-fueled cars equipped with catalyst produces significantly more CO during idle running than in the other phases, and the HC content is highest during deceleration. On the other hand NO{sub x} formation is highest during acceleration. Formation of CO, HC and aldehydes is lowest during steady driving, and the formation of NO{sub x} during deceleration. CO and NO{sub x} emissions of diesel engines are highest during acceleration, and HC emissions during idle running. Total emissions of diesel

  4. Effects of speed bottleneck on traffic flow with feedback control signal

    Science.gov (United States)

    Zhu, Kangli; Bi, Jiantao; Wu, Jianjun; Li, Shubin

    2016-09-01

    Various car-following models (CMs) have been developed to capture the complex characteristics of microscopic traffic flow, among which the coupled map CM can better reveal and reflect various phenomena of practical traffic flow. Capacity change at bottleneck contributes to high-density traffic flow upstream the bottleneck and contains very complex dynamic behavior. In this paper, we analyze the effect of speed bottleneck on the spatial-temporal evolution characteristics of traffic flow, and propose a method to reduce traffic congestion with the feedback control signal based on CM. Simulation results highlight the potential of using the feedback signal to control the stop-and-go wave and furthermore to alleviate the traffic congestion effectively.

  5. Influence of lane change on stability analysis for two-lane traffic flow

    Institute of Scientific and Technical Information of China (English)

    Zheng Liang; Ma Shou-Feng; Zhong Shi-Quan

    2011-01-01

    This paper deals mainly with the influence of lane changing behaviours on the stability of two-lane traffic flow under a periodic boundary condition.Following the description of an optimal velocity model for two vehicle groups and the derivation of their stability conditions,the feedback signals,which involve information about vehicles from both lanes acting on the two-lane traffic system,are introduced into the optimal velocity model.The control signals play a role in alleviating the traffic jam only if the traffic state is in congestion,and their role will vanish if the traffic state is in the steady state.The numerical simulations show that lane changing behaviours can break the steady state of two-lane traffic flow and aggravate the traffic disturbance,but the control method would successfully suppress the traffic jam eventually,which implies that the conclusions obtained here have certain theoretical and practical significance.

  6. Increasing Market Penetration of LED Traffic Signals in New York State: Review of Articles and Information on LED Traffic Signals

    OpenAIRE

    Bullough, John D; Suozzo, Margaret

    2002-01-01

    A primary purpose of this review is to identify and summarize recently published information about the use and performance of light-emitting diode (LED) traffic signals. It consists of two sections: a synopsis of experiences of municipalities using LED traffic signals in 1999 and 2000, and a discussion of technical, economic and market issues surrounding the deployment of LED signals. This review includes articles and reports published in 1999 and 2000.

  7. Joint optimization traffic signal control for an urban arterial road

    Institute of Scientific and Technical Information of China (English)

    LI Yin-fei; CHEN Shu-ping

    2009-01-01

    This paper considers the optimal traffic signal setting for an urban arterial road. By introducing the concepts of synchronization rate and non-synchronization degree, a mathematical model is constructed and an optimization problem is posed. Then, a new iterative algorithm is developed to solve this optimal traffic control signal setting problem. Convergence properties for this iterative algorithm are established. Finally, a numerical example is solved to illustrate the effectiveness of the method.

  8. Assessing the impact of road traffic on cycling for leisure and cycling to work

    Directory of Open Access Journals (Sweden)

    Wareham Nicholas J

    2011-06-01

    Full Text Available Abstract Background To explore the relationship between leisure and commuter cycling with objectively measured levels of road traffic and whether any relationship was affected by traffic levels directly outside of home or in local neighbourhood. Findings We conducted a secondary analysis of data from the UK European Prospective Investigation of Cancer (EPIC Norfolk cohort in 2009. We used a geographical information system (GIS and gender specific multivariate models to relate 13 927 participants' reported levels of cycling with an index of road traffic volume (Road Traffic Volume Index Score - RTVIS. RTVIS were calculated around each participants home, using four distance based buffers, (0.5 km, 1 km, 2 km and 3.2 km. Models were adjusted for age, social status, education, car access and deprivation. Both genders had similar decreases in leisure cycling as traffic volumes increased at greater distances from home (OR 0.42, (95% CI 0.32-0.52, p Conclusions Traffic volumes appear to have greater impact on leisure cycling than commuter cycling. Future research should investigate the importance of traffic on different types of cycling and include psychosocial correlates.

  9. An extended signal control strategy for urban network traffic flow

    Science.gov (United States)

    Yan, Fei; Tian, Fuli; Shi, Zhongke

    2016-03-01

    Traffic flow patterns are in general repeated on a daily or weekly basis. To improve the traffic conditions by using the inherent repeatability of traffic flow, a novel signal control strategy for urban networks was developed via iterative learning control (ILC) approach. Rigorous analysis shows that the proposed learning control method can guarantee the asymptotic convergence. The impacts of the ILC-based signal control strategy on the macroscopic fundamental diagram (MFD) were analyzed by simulations on a test road network. The results show that the proposed ILC strategy can evenly distribute the accumulation in the network and improve the network mobility.

  10. GPS Tracking System Coupled With Image Processing in Traffic Signals to Enhance Life Security

    Directory of Open Access Journals (Sweden)

    Manoj Prabhakar k

    2013-08-01

    Full Text Available In modern and crowded traffic life, it becomes mandatory to save the human life by reaching the hospitalvery sooner than possible. This paper explains about the advancement in tracking the ambulance presenceamidst the traffic with the usage of GPS tracking system calculating the position of the ambulance from thetraffic signal which replaces the RF transmitter receiver circuitry. This paper also retains the use of theimage capturing technology available from the base paper (IMPACT OF IMAGE PROCESSING INSAVING THE HUMAN LIFE BY AUTOMATING TRAFFIC SIGNALS to identify the presence of theambulance, thereby changing the signalto green automatically in favour of ambulance

  11. Development of an Interval Management Algorithm Using Ground Speed Feedback for Delayed Traffic

    Science.gov (United States)

    Barmore, Bryan E.; Swieringa, Kurt A.; Underwood, Matthew C.; Abbott, Terence; Leonard, Robert D.

    2016-01-01

    One of the goals of NextGen is to enable frequent use of Optimized Profile Descents (OPD) for aircraft, even during periods of peak traffic demand. NASA is currently testing three new technologies that enable air traffic controllers to use speed adjustments to space aircraft during arrival and approach operations. This will allow an aircraft to remain close to their OPD. During the integration of these technologies, it was discovered that, due to a lack of accurate trajectory information for the leading aircraft, Interval Management aircraft were exhibiting poor behavior. NASA's Interval Management algorithm was modified to address the impact of inaccurate trajectory information and a series of studies were performed to assess the impact of this modification. These studies show that the modification provided some improvement when the Interval Management system lacked accurate trajectory information for the leading aircraft.

  12. Theory of self-organized traffic at light signal

    CERN Document Server

    Kerner, Boris S

    2012-01-01

    Based on numerical simulations of a three-phase traffic flow model, a probabilistic theory of traffic at the light signal is developed. We have found that very complex spatiotemporal self-organized phenomena determine features of city traffic. We have revealed that the breakdown of {\\it green wave} in a city is initiated by the emergence of a moving synchronized flow pattern (MSP) within the green wave. It turns out that a sequence of F$\\rightarrow$S$\\rightarrow$J transitions (F -- free flow, S -- synchronized flow, J -- moving queue) lead to traffic breakdown at the light signal. Both spontaneous and induced breakdowns of the green wave have been found. From a study of a variety of scenarios for arrival traffic, we have found that there are the infinite number of capacities of traffic at the light signal, which are in a capacity range between a minimum capacity and maximum capacity; each of the capacities gives a flow rate at which under-saturated traffic is in a metastable state with respect to the transiti...

  13. Traffic routes and signals for the tonoplast.

    Science.gov (United States)

    Pedrazzini, Emanuela; Komarova, Nataliya Y; Rentsch, Doris; Vitale, Alessandro

    2013-06-01

    Tonoplast, the membrane delimiting plant vacuoles, regulates ion, water and nutrient movement between the cytosol and the vacuolar lumen through the activity of its membrane proteins. Correct traffic of proteins from the endoplasmic reticulum (ER) to the tonoplast requires (i) approval by the ER quality control, (ii) motifs for exit from the ER and (iii) motifs that promote sorting to the tonoplast. Recent evidence suggests that this traffic follows different pathways that are protein-specific and could also reflect vacuole specialization for lytic or storage function. The routes can be distinguished based on their sensitivity to drugs such as brefeldin A and C834 as well as using mutant plants that are defective in adaptor proteins of vesicle coats, or dominant-negative mutants of Rab GTPases.

  14. Study on Signal Intersection Traffic Flow Characteristics in Ice Conditions

    Directory of Open Access Journals (Sweden)

    Rui Ouyang

    2014-07-01

    Full Text Available As the component of urban transportation network, the intersection is the main part of traffic accidents and the bottleneck of restricting the smoothness of the transportation system. There are signalized intersection and non-signalized intersection, and the former is the main form at the intersection. So the evaluation of the service level under ice and snowfall conditions is significant. In the paper, we analysis the basic parameter of intersection signal control and operating characteristics of straight, right turn, left turn traffic flow in ice and snow condition, and we propose a traffic delay time model. On this basis, according to the snowfall intensity and respectively to the lanes and the whole intersection traffic flow as the object of study, we study the average delay in signal intersection in normal weather, slight snow, heavy snow and blizzard. With snow and ice conditions as starting point, the paper calculates the traffic capacities of signalized intersection under various snow and ice conditions. We compare the results of the calculation model and the actual measurement results, finally get the conclusion: the average delay time model can better express the vehicle at signalized intersection, in which the maximum deviation is 16.73%, and only appear once, twice the maximum deviation is 13.58%, and calibrate the snow and cold weather delayed mixed model.

  15. Signal optimization in urban transports: TASEP with traffic lights

    CERN Document Server

    Arita, Chikashi; Santen, Ludger

    2016-01-01

    We consider the exclusion process on a ring with time-dependent defective bonds at which the hoping rate periodically switches between zero and one. This system models main roads in city traffics, intersecting with perpendicular streets. We explore basic properties of the system, in particular dependence of the vehicular flow on the parameters of signalization as well as the system size and the car density. We investigate various types of the spatial distribution of the vehicular density, and show existence of a shock profile. We also measure waiting time behind traffic lights, and examine its relationship with the traffic flow.

  16. Emergency vehicle traffic signal preemption system

    Science.gov (United States)

    Bachelder, Aaron D. (Inventor); Foster, Conrad F. (Inventor)

    2011-01-01

    An emergency vehicle traffic light preemption system for preemption of traffic lights at an intersection to allow safe passage of emergency vehicles. The system includes a real-time status monitor of an intersection which is relayed to a control module for transmission to emergency vehicles as well as to a central dispatch office. The system also provides for audio warnings at an intersection to protect pedestrians who may not be in a position to see visual warnings or for various reasons cannot hear the approach of emergency vehicles. A transponder mounted on an emergency vehicle provides autonomous control so the vehicle operator can attend to getting to an emergency and not be concerned with the operation of the system. Activation of a priority-code (i.e. Code-3) situation provides communications with each intersection being approached by an emergency vehicle and indicates whether the intersection is preempted or if there is any conflict with other approaching emergency vehicles. On-board diagnostics handle various information including heading, speed, and acceleration sent to a control module which is transmitted to an intersection and which also simultaneously receives information regarding the status of an intersection. Real-time communications and operations software allow central and remote monitoring, logging, and command of intersections and vehicles.

  17. Acoustic Signal based Traffic Density State Estimation using SVM

    Directory of Open Access Journals (Sweden)

    Prashant Borkar

    2013-06-01

    Full Text Available Based on the information present in cumulative acoustic signal acquired from a roadside-installed single microphone, this paper considers the problem of vehicular traffic density state estimation. The occurrence and mixture weightings of traffic noise signals (Tyre, Engine, Air Turbulence, Exhaust, and Honks etc are determined by the prevalent traffic density conditions on the road segment. In this work, we extract the short-term spectral envelope features of the cumulative acoustic signals using MFCC (Mel-Frequency Cepstral Coefficients. Support Vector Machines (SVM is used as classifier is used to model the traffic density state as Low (40 Km/h and above, Medium (20-40 Km/h, and Heavy (0-20 Km/h. For the developing geographies where the traffic is non-lane driven and chaotic, other techniques (magnetic loop detectors are inapplicable. SVM classifier with different kernels are used to classify the acoustic signal segments spanning duration of 20–40 s, which results in average classification accuracy of 96.67% for Quadratic kernel function and 98.33% for polynomial kernel function, when entire frames are considered for classification.

  18. Traffic flow model at fixed control signals with discrete service time distribution

    Directory of Open Access Journals (Sweden)

    Lucky I. Igbinosun

    2016-04-01

    Full Text Available Most of the models of road traffic flow at fixed-cycle controlled intersection assume stationary distributions and provide steady state results. The assumption that a constant number of vehicles can leave the system during the green phase is unrealistic in real life situations. A discrete time queuing model was developed to describe the operation of traffic flow at a road intersection with fixed-cycle signalized control and to account for the randomness in the number of vehicles that can leave the system. The results show the expected queue size in the system when the traffic is light and for a busy period, respectively. For the light period, when the traffic intensity is less than one, it takes a shorter green cycle time for vehicles to clear up than during high traffic intensity (the road junction is saturated. Increasing the number of cars that can leave the junction at the turn of the green phase reduces the number of cycle times before the queue is cleared.

  19. Physiological responses to an acute bout of sprint interval cycling.

    Science.gov (United States)

    Freese, Eric C; Gist, Nicholas H; Cureton, Kirk J

    2013-10-01

    Sprint interval training has been shown to improve skeletal muscle oxidative capacity, V[Combining Dot Above]O2max, and health outcomes. However, the acute physiological responses to 4-7 maximal effort intervals have not been determined. To determine the V[Combining Dot Above]O2, cardiorespiratory responses, and energy expenditure during an acute bout of sprint interval cycling (SIC), health, college-aged subjects, 6 men and 6 women, completed 2 SIC sessions with at least 7 days between trials. Sprint interval cycling was performed on a cycle ergometer and involved a 5-minute warm-up followed by four 30-second all-out sprints with 4-minute active recovery. Peak oxygen uptake (ml·kg·min) during the 4 sprints were 35.3 ± 8.2, 38.8 ± 10.1, 38.8 ± 10.6, and 36.8 ± 9.3, and peak heart rate (b·min) were 164 ± 17, 172 ± 10, 177 ± 12, and 175 ± 22. We conclude that an acute bout of SIC elicits submaximal V[Combining Dot Above]O2 and cardiorespiratory responses during each interval that are above 80% of estimated maximal values. Although the duration of exercise in SIC is very short, the high level of V[Combining Dot Above]O2 and cardiorespiratory responses are sufficient to potentially elicit adaptations to training associated with elevated aerobic energy demand.

  20. Assessing the impact of road traffic on cycling for leisure and cycling to work

    OpenAIRE

    Wareham Nicholas J; Panter Jenna R; Foster Charlie E

    2011-01-01

    Abstract Background To explore the relationship between leisure and commuter cycling with objectively measured levels of road traffic and whether any relationship was affected by traffic levels directly outside of home or in local neighbourhood. Findings We conducted a secondary analysis of data from the UK European Prospective Investigation of Cancer (EPIC) Norfolk cohort in 2009. We used a geographical information system (GIS) and gender specific multivariate models to relate 13 927 partici...

  1. The Use of Audible Traffic Signals in the United States.

    Science.gov (United States)

    Peck, A. F.; Uslan, M.

    1990-01-01

    This paper discusses audible traffic signals (ATS) and their use by visually impaired pedestrians in the United States and other countries. Areas of concern are noted, including the types of intersections at which ATS should be installed, the locations of poles and buttons for activating the system, and the specific type of device used.…

  2. Infiuence of Bicycle Traffic on Capacity of Typical Signalized Intersection

    Institute of Scientific and Technical Information of China (English)

    CHEN Xiaoming; SHAO Chunfu; YUE Hao

    2007-01-01

    Bicycle traffic has a significant effect on the capacity of signalized intersections. This paper divides the influence of bicyclists on vehicular flow into four types with the time durations estimated based on probability, shock wave, and gap acceptance theory. Vehicular saturation flow rate is predicted for various conditions on the basis of the speed-flow curve for the capacity of typical intersections influenced by bicycle traffic.The model overcomes the limitations of the Highway Capacity Manual (HCM, 2000) method for left-turns due to data collection, and takes into account the effect of trapped bicycles on the through vehicular traffic.The numerical results show that the left-turn and through capacities predicted by the model are lower than those of the HCM method. The right-turn capacity is close to that of the HCM method at Iow bicycle volumes and higher than that of the HCM method at high bicycle volumes.

  3. Research on Driver Behavior in Yellow Interval at Signalized Intersections

    OpenAIRE

    Zhaosheng Yang; Xiujuan Tian; Wei Wang; Xiyang Zhou; Hongmei Liang

    2014-01-01

    Vehicles are often caught in dilemma zone when they approach signalized intersections in yellow interval. The existence of dilemma zone which is significantly influenced by driver behavior seriously affects the efficiency and safety of intersections. This paper proposes the driver behavior models in yellow interval by logistic regression and fuzzy decision tree modeling, respectively, based on camera image data. Vehicle’s speed and distance to stop line are considered in logistic regression m...

  4. From Cellular Attractor Selection to Adaptive Signal Control for Traffic Networks

    Science.gov (United States)

    Tian, Daxin; Zhou, Jianshan; Sheng, Zhengguo; Wang, Yunpeng; Ma, Jianming

    2016-03-01

    The management of varying traffic flows essentially depends on signal controls at intersections. However, design an optimal control that considers the dynamic nature of a traffic network and coordinates all intersections simultaneously in a centralized manner is computationally challenging. Inspired by the stable gene expressions of Escherichia coli in response to environmental changes, we explore the robustness and adaptability performance of signalized intersections by incorporating a biological mechanism in their control policies, specifically, the evolution of each intersection is induced by the dynamics governing an adaptive attractor selection in cells. We employ a mathematical model to capture such biological attractor selection and derive a generic, adaptive and distributed control algorithm which is capable of dynamically adapting signal operations for the entire dynamical traffic network. We show that the proposed scheme based on attractor selection can not only promote the balance of traffic loads on each link of the network but also allows the global network to accommodate dynamical traffic demands. Our work demonstrates the potential of bio-inspired intelligence emerging from cells and provides a deep understanding of adaptive attractor selection-based control formation that is useful to support the designs of adaptive optimization and control in other domains.

  5. Changes in Cortical Oxyhaemoglobin Signal During Low-Intensity Cycle Ergometer Activity: A Near-Infrared Spectroscopy Study.

    Science.gov (United States)

    Tsubaki, Atsuhiro; Takai, Haruna; Kojima, Sho; Miyaguchi, Shota; Sugawara, Kazuhiro; Sato, Daisuke; Tamaki, Hiroyuki; Onishi, Hideaki

    2016-01-01

    Near-infrared spectroscopy (NIRS) is a widely used non-invasive method for measuring human brain activation based on the cerebral hemodynamic response during gross motor tasks. However, systemic changes can influence measured NIRS signals. We aimed to determine and compare time-dependent changes in NIRS signal, skin blood flow (SBF), and mean arterial pressure (MAP) during low-intensity, constant, dynamic exercise. Nine healthy volunteers (22.1±1.7 years, 3 women) participated in this study. After a 4-min pre-exercise rest and a 4-min warm-up, they exercised on a bicycle ergometer at workloads corresponding to 30% VO2 peak for 20 min. An 8-min rest period followed the exercise. Cortical oxyhaemoglobin signals (O2Hb) were recorded while subjects performed the exercise, using an NIRS system. Changes in SBF and MAP were also measured during exercise. O2Hb increased to 0.019 mM cm over 6 min of exercise, decreased slightly from 13 min towards the end of the exercise. SBF continued to increase over 16 min of the exercise period and thereafter decreased till the end of measurement. MAP fluctuated from -1.0 to 7.1 mmHg during the exercise. Pearson's correlation coefficients between SBF and O2Hb, and MAP and O2Hb differed in each time phase, from -0.365 to 0.713. During low-intensity, constant, dynamic exercise, the profile of changes in measurements of O2Hb, SBF, and MAP differed. These results suggested that it is necessary to confirm the relationship between O2Hb and systemic factors during motor tasks in order to detect cortical activation during gross motor tasks. PMID:26782198

  6. A comparative study of Macroscopic Fundamental Diagrams of urban road networks governed by different traffic signal systems

    CERN Document Server

    Zhang, Lele; de Gier, Jan

    2011-01-01

    Using a stochastic cellular automaton model for urban traffic flow, we study and compare Macroscopic Fundamental Diagrams (MFDs) of arterial road networks governed by different types of adaptive traffic signal systems. In particular, we simulate realistic signal systems that include signal linking and adaptive cycle times, and compare their performance against a network using highly adaptive self-organizing traffic signals. We find that for networks with time- independent boundary conditions, well-defined stationary MFDs are observed, whose shape depends on the particular signal system used, and also on the level of heterogeneity in the system. We find that the spatial heterogeneity of both density and flow provide important indicators of network performance. We also study networks with time-dependent boundary conditions, containing morning and afternoon peaks. In this case, intricate hysteresis loops are observed in the MFDs which are strongly correlated with the density heterogeneity. Our results show that ...

  7. Modeling Traffic Flow and Management at Un-signalized, Signalized and Roundabout Road Intersections

    Directory of Open Access Journals (Sweden)

    R. Kakooza

    2005-01-01

    Full Text Available Traffic congestion continues to hinder economic and social development and also has a negative impact on the environment. A simple mathematical model is used to analyze the different types of road intersections in terms of their Performance in relation to managing traffic congestion and to establish the condition for stability of the road intersections after sufficiently longer periods of time (steady-state. In the analysis, single and double lane un-signalized, signalized and roundabout intersections are evaluated on the basis of their performance (expected number of vehicles and waiting time. Experimental scenarios are carefully designed to analyze the performance of the different types of intersections. It is noted that under light traffic, roundabout intersections perform better than un-signalized and signalized in terms of easing congestion. However under heavy traffic, signalized intersection perform better in terms of easing traffic congestion compared to un-signalized and roundabout intersections. It is further noted that for stability of a road intersection, the proportion of the time a road link stopping at an intersection is delayed should not exceed the utilization factor (the ratio of the arrival rate of vehicles to the product of number of service channels and service rate.

  8. Safety perceptions and behavior related to cycling in mixed traffic: A comparison between Brisbane and Copenhagen

    DEFF Research Database (Denmark)

    Chataway, Elijah Steven; Kaplan, Sigal; Nielsen, Thomas Alexander Sick;

    2014-01-01

    This study explores the differences in safety perceptions and reported behavior of cyclists in mixed traffic between an emerging cycling city (Brisbane, Australia) and an established cycling city (Copenhagen, Denmark). Perceptions and reported behavior were retrieved from a custom-designed web......-based survey administered among cyclists in the two cities. Elicited items concerned perceived risk of infrastructure layouts, fear of traffic, cycling while distracted, use of safety gear, cycling avoidance due to feeling unsafe, and avoidance to cycle in mixed traffic conditions. The data were analyzed...... with structural equation models. Results show that, in comparison with cyclists in Copenhagen, cyclists in Brisbane perceive mixed traffic infrastructure layouts as less safe, feel more fear of traffic, and are more likely to adopt cycling avoidance as a coping strategy. Results also show that cyclists...

  9. Traffic Congestion Evaluation and Signal Control Optimization Based on Wireless Sensor Networks: Model and Algorithms

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    2012-01-01

    Full Text Available This paper presents the model and algorithms for traffic flow data monitoring and optimal traffic light control based on wireless sensor networks. Given the scenario that sensor nodes are sparsely deployed along the segments between signalized intersections, an analytical model is built using continuum traffic equation and develops the method to estimate traffic parameter with the scattered sensor data. Based on the traffic data and principle of traffic congestion formation, we introduce the congestion factor which can be used to evaluate the real-time traffic congestion status along the segment and to predict the subcritical state of traffic jams. The result is expected to support the timing phase optimization of traffic light control for the purpose of avoiding traffic congestion before its formation. We simulate the traffic monitoring based on the Mobile Century dataset and analyze the performance of traffic light control on VISSIM platform when congestion factor is introduced into the signal timing optimization model. The simulation result shows that this method can improve the spatial-temporal resolution of traffic data monitoring and evaluate traffic congestion status with high precision. It is helpful to remarkably alleviate urban traffic congestion and decrease the average traffic delays and maximum queue length.

  10. Variation regularity of metal magnetic memory signals with inspecting time-interval and location

    Institute of Scientific and Technical Information of China (English)

    YAN Chun-yan; LI Wu-shen; DI Xin-jie; XUE Zhen-kui; BAI Shi-wu; LIU Fang-ming

    2007-01-01

    Influences of inspecting time-interval and location on varying behavior of metal magnetic memory (MMM) signals of defects were studied. Different areas in two precracked weldments were inspected at different time-intervals by type TSC-1M-4stress-concentration magnetic inspector to obtain MMM signals. Mechanisms of MMM signals varying behavior with inspecting time and space were analyzed and discussed respectively. It is found that MMM signals don't change with inspecting time-interval,since stress field and magnetic leakage field maintain unchanged at any time after welding. On the other hand, MMM signals differ greatly for different inspecting locations, because stress field and magnetic leakage field are unevenly distributed in defective ferromagnetic materials.

  11. 平面交叉口的另一种交通信号控制%Traffic flow equilibrium saturation when the traffic signal control

    Institute of Scientific and Technical Information of China (English)

    李雪佳; 秦敏

    2012-01-01

      建立可改变信号周期的交通流模型,利用最优控制理论和算法给出优化的信号配时控制策略,其结果与传统的信号配时设计非常接近。%  Establish may alter the signal cycle of the traffic flow model, using the optimal control theory and algorithm are presented to optimize the signal timing control strategy, the result with the traditional signal timing design is very close.

  12. Research on Driver Behavior in Yellow Interval at Signalized Intersections

    Directory of Open Access Journals (Sweden)

    Zhaosheng Yang

    2014-01-01

    Full Text Available Vehicles are often caught in dilemma zone when they approach signalized intersections in yellow interval. The existence of dilemma zone which is significantly influenced by driver behavior seriously affects the efficiency and safety of intersections. This paper proposes the driver behavior models in yellow interval by logistic regression and fuzzy decision tree modeling, respectively, based on camera image data. Vehicle’s speed and distance to stop line are considered in logistic regression model, which also brings in a dummy variable to describe installation of countdown timer display. Fuzzy decision tree model is generated by FID3 algorithm whose heuristic information is fuzzy information entropy based on membership functions. This paper concludes that fuzzy decision tree is more accurate to describe driver behavior at signalized intersection than logistic regression model.

  13. A Simulated System for Traffic Signal Management Based on Integrating GIS & WSN Techniques

    Directory of Open Access Journals (Sweden)

    Ahmed S. Elmotelb

    2016-01-01

    Full Text Available Traffic signals management systems (TSMS are traffic systems based on cameras, infrared sensors and satellite systems. Such systems have been lacking the ability of real-time data collection and support. This paper proposes a solution to the traffic signal management problem using combined techniques that combines both GIS information with WSN based techniques. This combination provide appropriate techniques and tools that will enhance the capabilities of traffic jam prevention, early detection, efficient surveillance, efficient spread control, and fast termination of possible hazards. Consequently, this work proposes a new methodology thrown merging WSN and GIS techniques to produce valuable information for traffic signals management systems purposes.

  14. Traffic signal design and simulation for vulnerable road users safety and bus preemption

    Science.gov (United States)

    Lo, Shih-Ching; Huang, Hsieh-Chu

    2015-01-01

    Mostly, pedestrian car accidents occurred at a signalized interaction is because pedestrians cannot across the intersection safely within the green light. From the viewpoint of pedestrian, there might have two reasons. The first one is pedestrians cannot speed up to across the intersection, such as the elders. The other reason is pedestrians do not sense that the signal phase is going to change and their right-of-way is going to be lost. Developing signal logic to protect pedestrian, who is crossing an intersection is the first purpose of this study. In addition, to improve the reliability and reduce delay of public transportation service is the second purpose. Therefore, bus preemption is also considered in the designed signal logic. In this study, the traffic data of the intersection of Chong-Qing North Road and Min-Zu West Road, Taipei, Taiwan, is employed to calibrate and validate the signal logic by simulation. VISSIM 5.20, which is a microscopic traffic simulation software, is employed to simulate the signal logic. From the simulated results, the signal logic presented in this study can protect pedestrians crossing the intersection successfully. The design of bus preemption can reduce the average delay. However, the pedestrian safety and bus preemption signal will influence the average delay of cars largely. Thus, whether applying the pedestrian safety and bus preemption signal logic to an intersection or not should be evaluated carefully.

  15. Synaptic membrane rafts: traffic lights for local neurotrophin signalling?

    Directory of Open Access Journals (Sweden)

    Barbara eZonta

    2013-10-01

    Full Text Available Lipid rafts, cholesterol and lipid rich microdomains, are believed to play important roles as platforms for the partitioning of transmembrane and synaptic proteins involved in synaptic signalling, plasticity and maintenance. There is increasing evidence of a physical interaction between post-synaptic densities and post-synaptic lipid rafts. Localization of proteins within lipid rafts is highly regulated, and therefore lipid rafts may function as traffic lights modulating and fine-tuning neuronal signalling. The tyrosine kinase neurotrophin receptors (Trk and the low-affinity p75 neurotrophin receptor (p75NTR are enriched in neuronal lipid rafts together with the intermediates of downstream signalling pathways, suggesting a possible role of rafts in neurotrophin signalling. Moreover, neurotrophins and their receptors are involved in the regulation of cholesterol metabolism. Cholesterol is an important component of lipid rafts and its depletion leads to gradual loss of synapses, underscoring the importance of lipid rafts for proper neuronal function. Here, we review and discuss the idea that translocation of neurotrophin receptors in synaptic rafts may account for the selectivity of their transduced signals.

  16. The role of optimization to control traffic signals setting on capacity and flow at peak hours at intersections

    Directory of Open Access Journals (Sweden)

    Pegah Jafari Haghighatpour

    2015-06-01

    Full Text Available Control the pre timing of traffic signals has many advantages because of its responsiveness to traffic demands, short cycles, and effective use of capacity leading to and recovering from oversaturation and amenability to aggressive transit priority. Traffic congestion in urban road and freeway networks leads to a strong degradation of the network infrastructure and accordingly reduced throughput, which can be countered via suitable control measures and strategies. Coordination between intersections in a central system increases capacity, appropriate traffic flow and reduce total delays of vehicles. Scats system has been installed in many world intersections, and many researchers have done about the advantages of it to decrease delays and travel times at intersection. SCATS is a modular system and development of this is possible. Now in Tehran's this system is used and traffic conditions matches on it. Traffic signal timing schedule gives in this system as default and although this system is capable of adapting to the moment traffic but in terms of super saturation and during peak hours due to the lack of optimization, default program around intersection has caused widespread congestion at intersection. In this paper, two intersections of East and West of Tehran have been selected, and in two different situations, the flow to capacity ratio of traffic signal timing has been investigated before and after optimization. Simulation by AIMSUN and optimization by SYNCHRO software is done. After optimization can be observed that if before the pre-defined schedule for SCATS, this plan for each intersection of the volume of traffic at peak hours has been optimized, a great reduction in delay and increase in capacity can be observed at intersections. For example, delay time reduction has been occurred about 14.77 in AM peak time and 12.65 in PM peak time at GOLBARG-DARDASHT intersection.

  17. Performance analysis of spectrum sensing with multiple status changes in primary user traffic

    KAUST Repository

    Tang, Liang

    2012-06-01

    In this letter, the impact of primary user traffic with multiple status changes on the spectrum sensing performance is analyzed. Closed-form expressions for the probabilities of false alarm and detection are derived. Numerical results show that the multiple status changes of the primary user cause considerable degradation in the sensing performance. This degradation depends on the number of changes, the primary user traffic model, the primary user traffic intensity and the signal-to-noise ratio of the received signal. Numerical results also show that the amount of degradation decreases when the number of changes increases, and converges to a minimum sensing performance due to the limited sensing period and primary holding time. © 2012 IEEE.

  18. Diurnal and Weekly Cycles in IPv6 Traffic

    OpenAIRE

    Strowes, Stephen D.

    2016-01-01

    IPv6 activity is commonly reported as a fraction of network traffic per day. Within this traffic, however, are daily and weekly characteristics, driven by non-uniform IPv6 deployment across ISPs and regions. This paper discusses some of the more apparent patterns we observe today.

  19. Traffic Signal Synchronization in the Saturated High-Density Grid Road Network

    Directory of Open Access Journals (Sweden)

    Xiaojian Hu

    2015-01-01

    Full Text Available Most existing traffic signal synchronization strategies do not perform well in the saturated high-density grid road network (HGRN. Traffic congestion often occurs in the saturated HGRN, and the mobility of the network is difficult to restore. In order to alleviate traffic congestion and to improve traffic efficiency in the network, the study proposes a regional traffic signal synchronization strategy, named the long green and long red (LGLR traffic signal synchronization strategy. The essence of the strategy is to control the formation and dissipation of queues and to maximize the efficiency of traffic flows at signalized intersections in the saturated HGRN. With this strategy, the same signal control timing plan is used at all signalized intersections in the HGRN, and the straight phase of the control timing plan has a long green time and a long red time. Therefore, continuous traffic flows can be maintained when vehicles travel, and traffic congestion can be alleviated when vehicles stop. Using the strategy, the LGLR traffic signal synchronization model is developed, with the objective of minimizing the number of stops. Finally, the simulation is executed to analyze the performance of the model by comparing it to other models, and the superiority of the LGLR model is evident in terms of delay, number of stops, queue length, and overall performance in the saturated HGRN.

  20. Traffic signal synchronization in the saturated high-density grid road network.

    Science.gov (United States)

    Hu, Xiaojian; Lu, Jian; Wang, Wei; Zhirui, Ye

    2015-01-01

    Most existing traffic signal synchronization strategies do not perform well in the saturated high-density grid road network (HGRN). Traffic congestion often occurs in the saturated HGRN, and the mobility of the network is difficult to restore. In order to alleviate traffic congestion and to improve traffic efficiency in the network, the study proposes a regional traffic signal synchronization strategy, named the long green and long red (LGLR) traffic signal synchronization strategy. The essence of the strategy is to control the formation and dissipation of queues and to maximize the efficiency of traffic flows at signalized intersections in the saturated HGRN. With this strategy, the same signal control timing plan is used at all signalized intersections in the HGRN, and the straight phase of the control timing plan has a long green time and a long red time. Therefore, continuous traffic flows can be maintained when vehicles travel, and traffic congestion can be alleviated when vehicles stop. Using the strategy, the LGLR traffic signal synchronization model is developed, with the objective of minimizing the number of stops. Finally, the simulation is executed to analyze the performance of the model by comparing it to other models, and the superiority of the LGLR model is evident in terms of delay, number of stops, queue length, and overall performance in the saturated HGRN.

  1. Novel P-Cycle protection strategy for asymmetric traffic in mesh optical networks

    Institute of Scientific and Technical Information of China (English)

    Bin LI; Yunhua ZANG; Yu DENG; Shanguo HUANG; Wanyi GU

    2008-01-01

    A novel prefigured-cycle(P-Cycle)algorithm was proposed to improve the protection success ratio for asymmetric traffic in mesh optical networks.The proposed algorithm was simulated in a Pan-European COST239 network environment under an asymmetric dynamic traffic model.The experimental results show that the proposed algorithm has lower capacity redundancy and higher utilization rate of configured resources than traditional P-Cycle methods.Network performance can be improved when implementing this algorithm under single-link failure circumstances.The system behavior is analyzed under different traffic volumes and the configuration strategy is also investigated for the heavyload and light-load networks respectively.

  2. Alignment of R-R interval signals using the circadian heart rate rhythm.

    Science.gov (United States)

    Gayraud, Nathalie T H; Manis, George

    2015-01-01

    R-R interval signals that come from different subjects are regularly aligned and averaged according to the horological starting time of the recordings. We argue that the horological time is a faulty alignment criterion and provide evidence in the form of a new alignment method. Our main motivation is that the human heart rate (HR) rhythm follows a circadian cycle, whose pattern can vary among different classes of people. We propose two novel alignment algorithms that consider the HR circadian rhythm, the Puzzle Piece Alignment Algorithm (PPA) and the Event Based Alignment Algorithm (EBA). First, we convert the R-R interval signal into a series of time windows and compute the mean HR per window. Then our algorithms search for matching circadian patterns to align the signals. We conduct experiments using R-R interval signals extracted from two databases in the Physionet Data Bank. Both algorithms are able to align the signals with respect to the circadian rhythmicity of HR. Furthermore, our findings confirm the presence of more than one pattern in the circadian HR rhythm. We suggest an automatic classification of signals according to the three most prominent patterns. PMID:26737009

  3. The Strongly Simple Cycles with Given Rotation Pairs of an Interval Map

    Institute of Scientific and Technical Information of China (English)

    Tai Xiang SUN; Hong Jian XI; Xiao Yan ZHANG

    2007-01-01

    In this paper, we introduce the notion of the strongly simple cycles with some rotation pair for interval maps and prove that, if an interval map has a cycle with given rotation pair, then it has a strongly simple cycle with the same rotation pair.

  4. A Dynamic Traffic Signal Timing Model and its Algorithm for Junction of Urban Road

    DEFF Research Database (Denmark)

    Cai, Yanguang; Cai, Hao

    2012-01-01

    As an important part of Intelligent Transportation System, the scientific traffic signal timing of junction can improve the efficiency of urban transport. This paper presents a novel dynamic traffic signal timing model. According to the characteristics of the model, hybrid chaotic quantum...... evolutionary algorithm, genetic algorithms and particle swarm optimization....

  5. Carbon isotopes of plant biomarkers record past changes in the carbon cycle, but separating signal from noise is key to reducing uncertainties

    Science.gov (United States)

    Diefendorf, A. F.; Freeman, K. H.; Wing, S. L.; Currano, E. D.

    2014-12-01

    The carbon isotopic composition of plant biomarkers (δ13C) can provide unique insights into the past carbon cycle perturbations and associated climate change, however local records are influenced by ecological processes, local climate, as well as changes in the carbon isotope composition of the atmosphere. To examine the sources and amounts of geographic variation, we focused on long-term changes in the carbon cycle. We combined modern calibrations, δ13C of biomarkers in sediment, and Monte Carlo analyses to measure and predict the fractionation of carbon isotopes by plants (Δleaf) and to estimate error. We used data from multiple sites of different ages, in the western U.S. For each age and location, Δleaf was calculated from the δ13C of plant biomarkers and atmospheric δ13C values inferred from marine carbonates. Δleaf values calculated from n-alkanes and triterpenoids (angiosperm biomarkers) were found to be the same at each site. Δleaf calculated from diterpenoids (conifer biomarkers) was 2‰ lower. This is consistent with differences in Δleaf between living angiosperms and conifers. Predicted Δleaf values, from modern calibrations and paleoclimate data, were consistently offset (0.7‰) from measured values indicating that modern calibrations are useful for reconciling past changes in plant fractionation and that vegetation and precipitation, like modern plants, were the key controls on Δleaf in ancient vegetation. However, uncertainties in the measured and predicted Δleaf values were very large (>2‰, 1σ). A one-at-a-time sensitivity analysis indicates that 'biological noise' in modern calibrations explains most of this uncertainty. If the full extent of this biological noise were transferred to sediments, then extracting signal from noise would be challenging. However, we speculate that the process of deposition homogenizes variability at the leaf and tree level thereby reducing 'biological noise' observed in modern calibrations.

  6. Social dilemma structures hidden behind traffic flow with lane changes

    International Nuclear Information System (INIS)

    Aiming to merge traffic flow analysis with evolutionary game theory, we investigated the question of whether such structures can be formed from frequent lane changes in usual traffic flow without any explicit bottlenecks. In our model system, two classes of driver-agents coexist: C-agents (cooperative strategy) always remain in the lane they are initially assigned, whereas D-agents (defective strategy) try to change lanes to move ahead. In relatively high-density flows, such as the metastable and high-density phases, we found structures that correspond to either n-person prisoner dilemma (n-PD) games or quasi-PD games. In these situations, lane changes by D-agents create heavy traffic jams that reduce social efficiency. (paper)

  7. [Weak signal detection in every heart cycle].

    Science.gov (United States)

    Yuan, J; Xu, X; Gao, D; Shi, G

    2001-12-01

    In this article, a new approach is introduced to lowering the myo-electronic noise in weak ECG signals. We use artificial neural network to make the noise be white, and then we adopt an adaptive filter of which the reference signal is achieved by extracting from other ECG cycle. The outcome is the reduction of both white noise and non-white noise in ECG signal. Satisfactory results have been achieved by using this method in the experiment of late potential detection.

  8. A Proposed Model for Traffic Signal Preemption Using Global Positioning System (GPS

    Directory of Open Access Journals (Sweden)

    Nikhil Mascarenhas

    2013-07-01

    Full Text Available A Traffic Signal Preemption system is an automated system that allows normal operation of traffic lights at automated signalized intersection s to be preempted. Preemption of signals is generally done to assist emergency vehicles, such a s ambulances, so that response times are reduced and right-of-way is provided in a smooth an d controlled manner. This paper proposes an innovative and cost-effective server-centric mod el to facilitate preemption using a simple mobile phone app which uses Global Positioning Syst em (GPS and a microcontroller which controls traffic signals.

  9. Thermodynamic efficiency of the cardiac cycle and irreversibility in the interbeat interval time series

    OpenAIRE

    Alejandro Muñoz-Diosdado; Gonzalo Gálvez-Coyt; Alejandro Alonso Martínez

    2010-01-01

    Cardiac cycle can be analyzed as a thermodynamic cycle, however, the inherent variability of this cycle implies that, although in the short term the cycle is quasi-reversible, in the long term is irreversible. This work discusses two important aspects of the cardiac cycle related with thermodynamic concepts: the calculation of the cycles efficiency and the quantification of the irreversibility of interbeat interval time series. The results show that there is a variability of cardiac eff...

  10. 10 CFR 431.224 - Uniform test method for the measurement of energy consumption for traffic signal modules and...

    Science.gov (United States)

    2010-01-01

    ... consumption for traffic signal modules and pedestrian modules. 431.224 Section 431.224 Energy DEPARTMENT OF... measurement of energy consumption for traffic signal modules and pedestrian modules. (a) Scope. This section... traffic signal modules and pedestrian modules. For purposes of 10 CFR part 431 and EPCA, the...

  11. Model predictive control for hybrid vehicle ecological driving using traffic signal and road slope information

    Institute of Scientific and Technical Information of China (English)

    Kaijiang YU; Junqi YANG; Daisuke YAMAGUCHI

    2015-01-01

    This paper presents development of a control system for ecological driving of a hybrid vehicle. Prediction using traffic signal and road slope information is considered to improve the fuel economy. It is assumed that the automobile receives traffic signal information from intelligent transportation systems (ITS). Model predictive control is used to calculate optimal vehicle control inputs using traffic signal and road slope information. The performance of the proposed method was analyzed through computer simulation results. Both the fuel economy and the driving profile are optimized using the proposed approach. It was observed that fuel economy was improved compared with driving of a typical human driving model.

  12. The RR interval spectrum, the ECG signal and aliasing

    CERN Document Server

    Gersten, A; Ronen, A; Cassuto, Y

    1999-01-01

    A reliable spectral analysis requires sampling rate at least twice as large as the frequency bound, otherwise the analysis will be unreliable and plagued with aliasing distortions. The RR samplings do not satisfy the above requirements and therefore their spectral analysis might be unreliable. In order to demonstrate the feasibility of aliasing in RR spectral analysis, we have done an experiment which have shown clearly how the aliasing was developed. In the experiments, one of us (A.G) had kept his high breathing rate constant with the aid of metronome for more than 5 minutes. The breathing rate was larger than one-half the heart rate. Very accurate results were obtained and the resulting aliasing well understood. To our best knowledge this is the first controlled experiment of this kind coducted on humans. We compared the RR spectral analysis with the spectrum of the ECG signals from which the RR intervals were extracted. In the significant for RR analysis frequencies (below one-half Hertz) significant diff...

  13. An improved response surface methodology algorithm with an application to traffic signal optimization for urban networks

    Energy Technology Data Exchange (ETDEWEB)

    Joshi, S.S.; Rathi, A.K. [Oak Ridge National Lab., TN (United States); Tew, J.D. [Consolidated Freightways, Inc., Portland, OR (United States). ISQ Dept.

    1995-12-31

    This paper illustrates the use of the simulation-optimization technique of response surface methodology (RSM) in traffic signal optimization of urban networks. It also quantifies the gains of using the common random number (CRN) variance reduction strategy in such an optimization procedure. An enhanced RSM algorithm which employs conjugate gradient search techniques and successive second-order models is presented instead of the conventional approach. An illustrative example using an urban traffic network exhibits the superiority of using the CRN strategy ovr direct simulation in performing traffic signal optimization. Relative performance of the two strategies is quantified with computational results using the total network-wide delay as the measure of effectivness.

  14. Symmetry breaking in optimal timing of traffic signals on an idealized two-way street

    Science.gov (United States)

    Panaggio, Mark J.; Ottino-Löffler, Bertand J.; Hu, Peiguang; Abrams, Daniel M.

    2013-09-01

    Simple physical models based on fluid mechanics have long been used to understand the flow of vehicular traffic on freeways; analytically tractable models of flow on an urban grid, however, have not been as extensively explored. In an ideal world, traffic signals would be timed such that consecutive lights turned green just as vehicles arrived, eliminating the need to stop at each block. Unfortunately, this “green-wave” scenario is generally unworkable due to frustration imposed by competing demands of traffic moving in different directions. Until now this has typically been resolved by numerical simulation and optimization. Here, we develop a theory for the flow in an idealized system consisting of a long two-way road with periodic intersections. We show that optimal signal timing can be understood analytically and that there are counterintuitive asymmetric solutions to this signal coordination problem. We further explore how these theoretical solutions degrade as traffic conditions vary and automotive density increases.

  15. Symmetry breaking in optimal timing of traffic signals on an idealized two-way street

    CERN Document Server

    Panaggio, Mark J; Hu, Peiguang; Abrams, Daniel M

    2013-01-01

    Simple physical models based on fluid mechanics have long been used to understand the flow of vehicular traffic on freeways; analytically tractable models of flow on an urban grid, however, have not been as extensively explored. In an ideal world, traffic signals would be timed such that consecutive lights turned green just as vehicles arrived, eliminating the need to stop at each block. Unfortunately, this "green wave" scenario is generally unworkable due to frustration imposed by competing demands of traffic moving in different directions. Until now this has typically been resolved by numerical simulation and optimization. Here, we develop a theory for the flow in an idealized system consisting of a long two-way road with periodic intersections. We show that optimal signal timing can be understood analytically and that there are counter-intuitive asymmetric solutions to this signal coordination problem. We further explore how these theoretical solutions degrade as traffic conditions vary and automotive dens...

  16. Road safety and bicycle usage impacts of unbundling vehicular and cycle traffic in Dutch urban networks.

    NARCIS (Netherlands)

    Schepers, P. Heinen, E. Methorst, R. & Wegman, F.

    2015-01-01

    Bicycle-motor vehicle crashes are concentrated along distributor roads where cyclists are exposed to greater volumes of high-speed motorists than they would experience on access roads. This study examined the road safety impact of network-level separation of vehicular and cycle traffic in Dutch urba

  17. Road safety and bicycle usage impacts of unbundling vehicular and cycle traffic in Dutch urban networks

    NARCIS (Netherlands)

    Schepers, P.; Heinen, E.; Methorst, R.; Wegman, F.C.M.

    2013-01-01

    Bicycle-motor vehicle crashes are concentrated along distributor roads where cyclists are exposed to greater volumes of high-speed motorists than they would experience on access roads. This study examined the road safety impact of network-level separation of vehicular and cycle traffic in Dutch urba

  18. Pre-hospital care time intervals among victims of road traffic injuries in Iran. A cross-sectional study

    Directory of Open Access Journals (Sweden)

    Bigdeli Maryam

    2010-07-01

    Full Text Available Abstract Background Road traffic injuries (RTIs are a major public health problem, requiring concerted efforts both for their prevention and a reduction of their consequences. Timely arrival of the Emergency Medical Service (EMS at the crash scene followed by speedy victim transportation by trained personnel may reduce the RTIs' consequences. The first 60 minutes after injury occurrence - referred to as the "golden hour"- are vital for the saving of lives. The present study was designed to estimate the average of various time intervals occurring during the pre-hospital care process and to examine the differences between these time intervals as regards RTIs on urban and interurban roads. Method A retrospective cross-sectional study was designed and various time intervals in relation to pre-hospital care of RTIs identified in the ambulance dispatch centre in Urmia, Iran from 20 March 2005 to 20 March 2007. All cases which resulted in ambulance dispatches were reviewed and those that had complete data on time intervals were analyzed. Results In total, the cases of 2027 RTI victims were analysed. Of these, 61.5 % of the subjects were injured in city areas. The mean response time for city locations was 5.0 minutes, compared with 10.6 minutes for interurban road locations. The mean on-scene time on the interurban roads was longer than on city roads (9.2 vs. 6.1 minutes, p Conclusion The response, transport and total time intervals among EMS responding to RTI incidents were longer for interurban roads, compared to the city areas. More research should take place on needs-to and access-for EMS on city and interurban roads. The notification interval seems to be a hidden part of the post-crash events and indirectly affects the "golden hour" for victim management and it needs to be measured through the establishment of the surveillance systems.

  19. Overcoming the Pigou-Downs Paradox Using Advanced Traffic Signal Control

    Science.gov (United States)

    Fowdur, S. C.; Rughooputh, S. D. D. V.

    2013-06-01

    Expansion of a road network has often been observed to cause more congestion and has led researchers to the formulation of traffic paradoxes such as the Pigou-Downs and the Braess paradoxes. In this paper, we present an application of advanced traffic signal control (ATSC) to overcome the Pigou-Downs paradox. Port Louis, the capital city of Mauritius is used to investigate the effect of using a harbor bridge to by-pass the city center. Using traffic cellular automata (TCA) simulations it has been shown how, if traffic is only gradually deviated along the by-pass, an overall longer travel time and decreased flux would result. By making use of ATSC, which involves traffic lights that sense the number of vehicles accumulated in the queue, better travel times and fluxes are achieved.

  20. Multi-Objective Optimization of Traffic Signal Timing for Oversaturated Intersection

    Directory of Open Access Journals (Sweden)

    Yan Li

    2013-01-01

    Full Text Available For the purpose of improving the efficiency of traffic signal control for isolate intersection under oversaturated conditions, a multi-objective optimization algorithm for traffic signal control is proposed. Throughput maximum and average queue ratio minimum are selected as the optimization objectives of the traffic signal control under oversaturated condition. A simulation environment using VISSIM SCAPI was utilized to evaluate the convergence and the optimization results under various settings and traffic conditions. It is written by C++/CRL to connect the simulation software VISSIM and the proposed algorithm. The simulation results indicated that the signal timing plan generated by the proposed algorithm has good efficiency in managing the traffic flow at oversaturated intersection than the commonly utilized signal timing optimization software Synchro. The update frequency applied in the simulation environment was 120 s, and it can meet the requirements of signal timing plan update in real filed. Thus, the proposed algorithm has the capability of searching Pareto front of the multi-objective problem domain under both normal condition and over-saturated condition.

  1. Traffic Signals Control with Adaptive Fuzzy Controller in Urban Road Network

    Institute of Scientific and Technical Information of China (English)

    LI Yan; FAN Xiao-ping

    2008-01-01

    An adaptive fuzzy logic controller (AFC) is presented for the signal control of the urban traffic network.The AFC is composed of the signal control system-oriented control level and the signal controller-oriented fuzzy rules regulation level.The control level decides the signal tunings in an intersection with a fuzzy logic controller.The regulation level optimizes the fuzzy rules by the Adaptive Rule Module in AFC according to both the system performance index in current control period and the traffic flows in the last one.Consequently the system performances are improved.A weight coefficient controller (WCC) is also developed to describe the interactions of traffic flow among the adjacent intersections.So the AFC combined with the WCC can be applied in a road network for signal timings.Simulations of the AFC on a real traffic scenario have been conducted.Simulation results indicate that the adaptive controller for traffic control shows better performance than the actuated one.

  2. Multiobjective Traffic Signal Control Model for Intersection Based on Dynamic Turning Movements Estimation

    Directory of Open Access Journals (Sweden)

    Pengpeng Jiao

    2014-01-01

    Full Text Available The real-time traffic signal control for intersection requires dynamic turning movements as the basic input data. It is impossible to detect dynamic turning movements directly through current traffic surveillance systems, but dynamic origin-destination (O-D estimation can obtain it. However, the combined models of dynamic O-D estimation and real-time traffic signal control are rare in the literature. A framework for the multiobjective traffic signal control model for intersection based on dynamic O-D estimation (MSC-DODE is presented. A state-space model using Kalman filtering is first formulated to estimate the dynamic turning movements; then a revised sequential Kalman filtering algorithm is designed to solve the model, and the root mean square error and mean percentage error are used to evaluate the accuracy of estimated dynamic turning proportions. Furthermore, a multiobjective traffic signal control model is put forward to achieve real-time signal control parameters and evaluation indices. Finally, based on practical survey data, the evaluation indices from MSC-DODE are compared with those from Webster method. The actual and estimated turning movements are further input into MSC-DODE, respectively, and results are also compared. Case studies show that results of MSC-DODE are better than those of Webster method and are very close to unavailable actual values.

  3. Qualitative change of fluctuation observed in real traffic flow

    Science.gov (United States)

    Yokoya, Yasushi

    2010-02-01

    We studied the nature of fluctuations around the phase transition of vehicular traffic by analyzing a time series of successive variations of velocity, obtained from single-vehicle data measured by an onboard apparatus. We found that the probability density function calculated from the time series of variation of velocity is transformed irreversibly in the critical region, where a Gaussian distribution changes into a Lévy stable symmetrical distribution. The power-law tail in the Lévy distribution indicated that the time series of velocity variation exhibits the nature of the critical fluctuations generally observed in phase transitions driven far from equilibrium. Furthermore, single-vehicle data enabled us to calculate the time evolution of the local flux-density relation, which suggested that the vehicular traffic system spontaneously approaches a delicate balance between metastable states and congested-flow states. The nature of fluctuations enables us to understand mechanisms behind the spontaneous decay of the metastable branch at the phase transition. The power-law tail in the probability density function suggests that dynamical processes of vehicular traffic in the critical region are related to a time-discrete stochastic process driven by random amplification with additive external noise.

  4. An RFID-Based Intelligent Vehicle Speed Controller Using Active Traffic Signals

    Directory of Open Access Journals (Sweden)

    Joshué Pérez

    2010-06-01

    Full Text Available These days, mass-produced vehicles benefit from research on Intelligent Transportation System (ITS. One prime example of ITS is vehicle Cruise Control (CC, which allows it to maintain a pre-defined reference speed, to economize on fuel or energy consumption, to avoid speeding fines, or to focus all of the driver’s attention on the steering of the vehicle. However, achieving efficient Cruise Control is not easy in roads or urban streets where sudden changes of the speed limit can happen, due to the presence of unexpected obstacles or maintenance work, causing, in inattentive drivers, traffic accidents. In this communication we present a new Infrastructure to Vehicles (I2V communication and control system for intelligent speed control, which is based upon Radio Frequency Identification (RFID technology for identification of traffic signals on the road, and high accuracy vehicle speed measurement with a Hall effect-based sensor. A fuzzy logic controller, based on sensor fusion of the information provided by the I2V infrastructure, allows the efficient adaptation of the speed of the vehicle to the circumstances of the road. The performance of the system is checked empirically, with promising results.

  5. Elicitation interval dependent spatiotemporal evolution of cortical spreading depression waves revealed by optical intrinsic signal imaging

    Science.gov (United States)

    Chen, Shangbin; Gong, Hui; Zeng, Shaoqun; Luo, Qingming; Li, Pengcheng

    2007-02-01

    This study aimed to investigate the variation of propagation patterns of successive cortical spreading depression (CSD) waves induced by K + or pinprick in rat cortex. In the K + induction group, 18 Sprague-Dawley rats under Î+/--chloralose/urethane anesthesia were used to elicit CSD by 1 M KCl solution in the frontal cortex. Optical intrinsic signal imaging (OISI) at an isosbestic point of hemoglobin (550 nm) was applied to examine regional cerebral blood volume (CBV) changes in the parieto-occipital cortex. In 6 of the 18 rats, OISI was performed in conjunction with DC potential recording of the cortex. The results of this group were reported previously. In the pinprick group, 6 rats were used to induce CSD by pinprick with 8 min interval, and the other 6 rats were pricked with 4 min. CBV changes during CSD appeared as repetitive propagation of wave-like hyperemia at a speed of 3.7+/-0.4 mm/min, which was characterized by a significant negative peak (-14.3+/-3.2%) in the reflectance signal. Except for the first CSD wave, the following waves don't spread fully in the observed cortex all the time and they might abort in the medial area. Independent on the stimulation of pinprick or K+, a short interval of the current CSD to the last CSD no more than 4 min would induce the current CSD be partially propagated. For the first time, the data reveals the time-varying propagation patterns of CSD waves might be affected by the interval between CSD waves. The results suggest that the propagation patterns of a series of CSD waves are time-varying in different regions of rat cortex, and the variation is related to the interval between CSD waves.

  6. Carbon cycle changes during the Triassic-Jurassic transition

    NARCIS (Netherlands)

    Ruhl, M.

    2010-01-01

    The end-Triassic is regarded as one of the five major mass extinction events of the Phanerozoic. This time interval is marked by up to 50% of marine biodiversity loss and major changes in terrestrial ecosystems. Mass extinction events are often marked by changes in the global carbon cycle. The reali

  7. Signaling a Change of Heart

    DEFF Research Database (Denmark)

    Schumacher, Gijs

    2011-01-01

    introduced welfare state retrenchment measures. Social Democrats can win votes and join coalitions by shifting rightwards. In contrast, they can pursue policy objectives by shifting leftwards. To communicate these shifts, in other words, ‘changes of heart’, parties send signals to voters and other parties...... after having signalled ‘a change of heart’....

  8. Effect of display update interval, update type, and background on perception of aircraft separation on a cockpit display on traffic information

    Science.gov (United States)

    Jago, S.; Baty, D.; Oconnor, S.; Palmer, E.

    1981-01-01

    The concept of a cockpit display of traffic information (CDTI) includes the integration of air traffic, navigation, and other pertinent information in a single electronic display in the cockpit. Concise display symbology was developed for use in later full-mission simulator evaluations of the CDTI concept. Experimental variables used included the update interval motion of the aircraft, the update type, (that is, whether the two aircraft were updated at the same update interval or not), the background (grid pattern or no background), and encounter type (straight or curved). Only the type of encounter affected performance.

  9. Life cycle cost optimization of biofuel supply chains under uncertainties based on interval linear programming.

    Science.gov (United States)

    Ren, Jingzheng; Dong, Liang; Sun, Lu; Goodsite, Michael Evan; Tan, Shiyu; Dong, Lichun

    2015-01-01

    The aim of this work was to develop a model for optimizing the life cycle cost of biofuel supply chain under uncertainties. Multiple agriculture zones, multiple transportation modes for the transport of grain and biofuel, multiple biofuel plants, and multiple market centers were considered in this model, and the price of the resources, the yield of grain and the market demands were regarded as interval numbers instead of constants. An interval linear programming was developed, and a method for solving interval linear programming was presented. An illustrative case was studied by the proposed model, and the results showed that the proposed model is feasible for designing biofuel supply chain under uncertainties. PMID:25827247

  10. Validity of Spontaneous Braking and Lane Changing with Scope of Awareness by Using Measured Traffic Flow

    OpenAIRE

    Kohei Arai; Steven Ray Sentinuwo

    2013-01-01

    This paper presents the validation method and its evaluation of the spontaneous braking and lane changing with scope awareness parameter. By using the real traffic flow data, the traffic cellular automaton model that accommodate these two driver behaviors, e.g., spontaneous braking and driver scope awareness has been compared and evaluated. The real traffic flow data have been observed via video-recording captured from real traffic situation. The validation results shown that by accommodate s...

  11. Self-organization of traffic jams in cities: Effects of stochastic dynamics and signal periods

    Science.gov (United States)

    Chowdhury, Debashish; Schadschneider, Andreas

    1999-02-01

    We propose a cellular automata model for vehicular traffic in cities by combining (and appropriately modifying) ideas borrowed from the Biham-Middleton-Levine (BML) model of city traffic and the Nagel-Schreckenberg (NS) model of highway traffic. We demonstrate a phase transition from the ``free-flowing'' dynamical phase to the completely ``jammed'' phase at a vehicle density which depends on the time periods of the synchronized signals and the separation between them. The intrinsic stochasticity of the dynamics, which triggers the onset of jamming, is similar to that in the NS model, while the phenomenon of complete jamming through self-organization as well as the final jammed configurations are similar to those in the BML model. Using our model, we have made an investigation of the time dependence of the average speeds of the cars in the ``free-flowing'' phase as well as the dependence of flux and jamming on the time period of the signals.

  12. Traffic analysis and signal processing in optical packet switched networks

    DEFF Research Database (Denmark)

    Fjelde, Tina

    2002-01-01

    Gbit/s demultiplexing and 2x10 to 20 Gbit/s multiplexing. Lastly, the IWC’s capabilities as an optical logic gate for enabling more complex signal processing are demonstrated and four applications hereof are discussed. Logic OR and AND are verified in full at 10 Gbit/s using PRBS sequences coupled......, involving all-optical pattern recognition by bit-wise sampling at multiple wavelengths, optical identification of bit differences in data segments through a combination of logic XOR and AND, and all optical bit sequence replacement through logic OR and AND. The schemes enable important signal processing...

  13. Cellular metabolic and autophagic pathways: traffic control by redox signaling.

    Science.gov (United States)

    Dodson, Matthew; Darley-Usmar, Victor; Zhang, Jianhua

    2013-10-01

    It has been established that the key metabolic pathways of glycolysis and oxidative phosphorylation are intimately related to redox biology through control of cell signaling. Under physiological conditions glucose metabolism is linked to control of the NADH/NAD redox couple, as well as providing the major reductant, NADPH, for thiol-dependent antioxidant defenses. Retrograde signaling from the mitochondrion to the nucleus or cytosol controls cell growth and differentiation. Under pathological conditions mitochondria are targets for reactive oxygen and nitrogen species and are critical in controlling apoptotic cell death. At the interface of these metabolic pathways, the autophagy-lysosomal pathway functions to maintain mitochondrial quality and generally serves an important cytoprotective function. In this review we will discuss the autophagic response to reactive oxygen and nitrogen species that are generated from perturbations of cellular glucose metabolism and bioenergetic function.

  14. The Combined Effect of Signal Strength and Background Traffic Load on Speech Quality in IEEE 802.11 WLAN

    Directory of Open Access Journals (Sweden)

    P. Pocta

    2011-04-01

    Full Text Available This paper deals with measurements of the combined effect of signal strength and background traffic load on speech quality in IEEE 802.11 WLAN. The ITU-T G.729AB encoding scheme is deployed in this study and the Distributed Internet Traffic Generator (D-ITG is used for the purpose of background traffic generation. The speech quality and background traffic load are assessed by means of the accomplished PESQ algorithm and Wireshark network analyzer, respectively. The results show that background traffic load has a bit higher impact on speech quality than signal strength when both effects are available together. Moreover, background traffic load also partially masks the impact of signal strength. The reasons for those findings are particularly discussed. The results also suggest some implications for designers of wireless networks providing VoIP service.

  15. Comparison of Cardiorespiratory and Metabolic Responses in Kettlebell High-Intensity Interval Training Versus Sprint Interval Cycling.

    Science.gov (United States)

    Williams, Brian M; Kraemer, Robert R

    2015-12-01

    The purpose of this study was to determine the effectiveness of a novel exercise protocol we developed for kettlebell high-intensity interval training (KB-HIIT) by comparing the cardiorespiratory and metabolic responses to a standard sprint interval cycling (SIC) exercise protocol. Eight men volunteered for the study and completed 2 preliminary sessions, followed by two 12-minute sessions of KB-HIIT and SIC in a counterbalanced fashion. In the KB-HITT session, 3 circuits of 4 exercises were performed using a Tabata regimen. In the SIC session, three 30-second sprints were performed, with 4 minutes of recovery in between the first 2 sprints and 2.5 minutes of recovery after the last sprint. A within-subjects' design over multiple time points was used to compare oxygen consumption (V[Combining Dot Above]O2), respiratory exchange ratio (RER), tidal volume (TV), breathing frequency (f), minute ventilation (VE), caloric expenditure rate (kcal·min), and heart rate (HR) between the exercise protocols. Additionally, total caloric expenditure was compared. A significant group effect, time effect, and group × time interaction were found for V[Combining Dot Above]O2, RER, and TV, with V[Combining Dot Above]O2 being higher and TV and RER being lower in the KB-HIIT compared with the SIC. Only a significant time effect and group × time interaction were found for f, VE, kcal·min, and HR. Additionally, total caloric expenditure was found to be significantly higher during the KB-HIIT. The results of this study suggest that KB-HIIT may be more attractive and sustainable than SIC and can be effective in stimulating cardiorespiratory and metabolic responses that could improve health and aerobic performance. PMID:26360962

  16. Transcriptome changes and cAMP oscillations in an archaeal cell cycle

    Directory of Open Access Journals (Sweden)

    Soppa Jörg

    2007-06-01

    Full Text Available Abstract Background The cell cycle of all organisms includes mass increase by a factor of two, replication of the genetic material, segregation of the genome to different parts of the cell, and cell division into two daughter cells. It is tightly regulated and typically includes cell cycle-specific oscillations of the levels of transcripts, proteins, protein modifications, and signaling molecules. Until now cell cycle-specific transcriptome changes have been described for four eukaryotic species ranging from yeast to human, but only for two prokaryotic species. Similarly, oscillations of small signaling molecules have been identified in very few eukaryotic species, but not in any prokaryote. Results A synchronization procedure for the archaeon Halobacterium salinarum was optimized, so that nearly 100% of all cells divide in a time interval that is 1/4th of the generation time of exponentially growing cells. The method was used to characterize cell cycle-dependent transcriptome changes using a genome-wide DNA microarray. The transcript levels of 87 genes were found to be cell cycle-regulated, corresponding to 3% of all genes. They could be clustered into seven groups with different transcript level profiles. Cluster-specific sequence motifs were detected around the start of the genes that are predicted to be involved in cell cycle-specific transcriptional regulation. Notably, many cell cycle genes that have oscillating transcript levels in eukaryotes are not regulated on the transcriptional level in H. salinarum. Synchronized cultures were also used to identify putative small signaling molecules. H. salinarum was found to contain a basal cAMP concentration of 200 μM, considerably higher than that of yeast. The cAMP concentration is shortly induced directly prior to and after cell division, and thus cAMP probably is an important signal for cell cycle progression. Conclusion The analysis of cell cycle-specific transcriptome changes of H. salinarum

  17. 基于交通噪声分析的交通流状态识别方法%Traffic Flow State Identification Based on Traffic Noise Signals

    Institute of Scientific and Technical Information of China (English)

    罗向龙

    2012-01-01

    A vehicle acoustic signal is composed of engine noise, tire noise, air turbulence noise and exhaust noise. Traffic noise signals mixture of multiple vehicles' acoustic signals is determined by the traffic state. Based on the analysis of the existing traffic state identification methods and vehicle sound characteristics, an identification method of the traffic flow state was proposed by using traffic noise signals. In accordance with the vehicle speed, traffic flow states were divided into the free flow, saturation flow and traffic jams. The spectrums of vehicle acoustic signals were analyzed for different traffic states, the normalized peak frequencies were as features, and different traffic flow states were recognized using support vector machine. The test results show that different traffic flow states can be correctly recognized with traffic noise signals with a high recognition accuracy.%车辆行驶时的声音主要由发动机噪声、轮胎噪声、空气涡流噪声、排气噪声组成,多个车辆构成的交通噪声取决于道路的交通流状态.在分析现有交通状态识别方法和车辆声音特性的基础上提出了一种利用交通噪声的交通状态识别方法.按照车速将交通流分为自由流、饱和流和交通拥堵3种状态,对不同交通流状态下的交通噪声信号进行谱分析,以归一化的峰值频率作为特征,用支持向量机对不同的交通流状态进行识别.试验结果表明,通过交通噪声能够正确识别不同的交通流状态,具有较高的识别精度.

  18. No exercise-induced increase in serum BDNF after cycling near a major traffic road.

    Science.gov (United States)

    Bos, I; Jacobs, L; Nawrot, T S; de Geus, B; Torfs, R; Int Panis, L; Degraeuwe, B; Meeusen, R

    2011-08-15

    Commuting by bike has a clear health enhancing effect. Moreover, regular exercise is known to improve brain plasticity, which results in enhanced cognition and memory performance. Animal research has clearly shown that exercise upregulates brain-derived neurotrophic factor (BDNF - a neurotrophine) enhancing brain plasticity. Studies in humans found an increase in serum BDNF concentration in response to an acute exercise bout. Recently, more evidence is emerging suggesting that exposure to air pollution (such as particulate matter (PM)) is higher in commuter cyclists compared to car drivers. Furthermore, exposure to PM is linked to negative neurological effects, such as neuroinflammation and cognitive decline. We carried-out a cross-over experiment to examine the acute effect of exercise on serum BDNF, and the potential effect-modification by exposure to traffic-related air pollution. Thirty eight physically fit, non-asthmatic volunteers (mean age: 43, 26% women) performed two cycling trials, one near a major traffic road (Antwerp Ring, R1, up to 260,000 vehicles per day) and one in an air-filtered room. The air-filtered room was created by reducing fine particles as well as ultrafine particles (UFP). PM10, PM2.5 and UFP were measured. The duration (∼20min) and intensity of cycling were kept the same for each volunteer for both cycling trials. Serum BDNF concentrations were measured before and 30min after each cycling trial. Average concentrations of PM10 and PM2.5 were 64.9μg/m(3) and 24.6μg/m(3) in cycling near a major ring way, in contrast to 7.7μg/m(3) and 2.0μg/m(3) in the air-filtered room. Average concentrations of UFP were 28,180 particles/cm(3) along the road in contrast to 496 particles/cm(3) in the air-filtered room. As expected, exercise significantly increased serum BDNF concentration after cycling in the air-filtered room (+14.4%; p=0.02). In contrast, serum BDNF concentrations did not increase after cycling near the major traffic route (+0.5%; p

  19. No exercise-induced increase in serum BDNF after cycling near a major traffic road.

    Science.gov (United States)

    Bos, I; Jacobs, L; Nawrot, T S; de Geus, B; Torfs, R; Int Panis, L; Degraeuwe, B; Meeusen, R

    2011-08-15

    Commuting by bike has a clear health enhancing effect. Moreover, regular exercise is known to improve brain plasticity, which results in enhanced cognition and memory performance. Animal research has clearly shown that exercise upregulates brain-derived neurotrophic factor (BDNF - a neurotrophine) enhancing brain plasticity. Studies in humans found an increase in serum BDNF concentration in response to an acute exercise bout. Recently, more evidence is emerging suggesting that exposure to air pollution (such as particulate matter (PM)) is higher in commuter cyclists compared to car drivers. Furthermore, exposure to PM is linked to negative neurological effects, such as neuroinflammation and cognitive decline. We carried-out a cross-over experiment to examine the acute effect of exercise on serum BDNF, and the potential effect-modification by exposure to traffic-related air pollution. Thirty eight physically fit, non-asthmatic volunteers (mean age: 43, 26% women) performed two cycling trials, one near a major traffic road (Antwerp Ring, R1, up to 260,000 vehicles per day) and one in an air-filtered room. The air-filtered room was created by reducing fine particles as well as ultrafine particles (UFP). PM10, PM2.5 and UFP were measured. The duration (∼20min) and intensity of cycling were kept the same for each volunteer for both cycling trials. Serum BDNF concentrations were measured before and 30min after each cycling trial. Average concentrations of PM10 and PM2.5 were 64.9μg/m(3) and 24.6μg/m(3) in cycling near a major ring way, in contrast to 7.7μg/m(3) and 2.0μg/m(3) in the air-filtered room. Average concentrations of UFP were 28,180 particles/cm(3) along the road in contrast to 496 particles/cm(3) in the air-filtered room. As expected, exercise significantly increased serum BDNF concentration after cycling in the air-filtered room (+14.4%; p=0.02). In contrast, serum BDNF concentrations did not increase after cycling near the major traffic route (+0.5%; p

  20. Study on Control Algorithm of Traffic Signals at Intersections Based on Optimizing Sub-area Traffic Flows%基于子区域交通流优化的交叉口信号控制研究

    Institute of Scientific and Technical Information of China (English)

    臧利林; 朱文兴

    2012-01-01

    In order to reduce average delay time of passing vehicles and improve urban area traffic efficiency, considering actual geographical characteristics of intersections and sub-area traffic data, a control model for traffic signals at intersections was built based on optimizing sub-area traffic flows, and genetic algorithm was used to find out the optimal solution of the model. With traffic signals coordination of neighboring intersections considered, vehicle minimal delay time was chosen as the optimization object in the model. HCM2000 was adopted to calculate vehicle delay time and Robertson model was embedded in the optimization procedure, which ensured the proposed model to be feasible and effective. VC+ 3- 6. 0 software was applied to programm and calculate an optimal control plan for traffic signals at intersections. Finally, simulation by CORSIM was implemented to verifythe validity of the control plan. The results show that the proposed model can obtain better traffic efficiency than the coordination control method based on existing common cycle, and provides a new signal control idea at intersections for urban traffic.%为了减少车辆平均延误时间,提高城市区域交通通行效率,结合实际交叉口地理特征和区域交通流数据,建立了一种基于子区域交通流优化的交叉口信号控制模型,并应用遗传算法获得模型的最优解。在模型中,考虑相邻交叉口信号之间的协调,以车辆平均延误时间最小为优化目标,采用HCM2000延误计算方法,并在优化过程中嵌入Robertson车队离散模型,保证提出模型的可行性和有效性。在VC++6.0中编写程序,获得交叉口信号最优控制方案,最后通过CORSIM仿真证明该控制方案的优劣。结果表明:与现有基于共同周期的协调控制方法相比,所提出的模型能够获得更优的交通效益,为区域交通信号控制提供了一种新的思路。

  1. Vertebral endplate signal changes (Modic change)

    DEFF Research Database (Denmark)

    Jensen, Tue Secher; Karppinen, Jaro; Sorensen, Joan S;

    2008-01-01

    The prevalence of "vertebral endplate signal changes" (VESC) and its association with low back pain (LBP) varies greatly between studies. This wide range in reported prevalence rates and associations with LBP could be explained by differences in the definitions of VESC, LBP, or study sample. The ...

  2. Characteristics of traffic flow at a non-signalized intersection in the framework of game theory

    Science.gov (United States)

    Fan, Hongqiang; Jia, Bin; Tian, Junfang; Yun, Lifen

    2014-12-01

    At a non-signalized intersection, some vehicles violate the traffic rules to pass the intersection as soon as possible. These behaviors may cause many traffic conflicts even traffic accidents. In this paper, a simulation model is proposed to research the effects of these behaviors at a non-signalized intersection. Vehicle’s movement is simulated by the cellular automaton (CA) model. The game theory is introduced for simulating the intersection dynamics. Two types of driver participate the game process: cooperator (C) and defector (D). The cooperator obey the traffic rules, but the defector does not. A transition process may occur when the cooperator is waiting before the intersection. The critical value of waiting time follows the Weibull distribution. One transition regime is found in the phase diagram. The simulation results illustrate the applicability of the proposed model and reveal a number of interesting insights into the intersection management, including that the existence of defectors is benefit for the capacity of intersection, but also reduce the safety of intersection.

  3. Repaired supraspinatus tendons in clinically improving patients: Early postoperative findings and interval changes on MRI

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jung Eun; Park, Ji Seon; Ryu, Kyung Nam; Rhee, Yong Girl [Kyung Hee University Hospital, Seoul (Korea, Republic of); Yoon, So Hee; Park, So Young; Jin Wook [Dept. of Radiology, Kyung Hee University Hospital at Gangdong, Seoul (Korea, Republic of)

    2015-04-15

    To demonstrate and further determine the incidences of repaired supraspinatus tendons on early postoperative magnetic resonance imaging (MRI) findings in clinically improving patients and to evaluate interval changes on follow-up MRIs. Fifty patients, who showed symptomatic and functional improvements after supraspinatus tendon repair surgery and who underwent postoperative MRI twice with a time interval, were included. The first and the second postoperative MRIs were obtained a mean of 4.4 and 11.5 months after surgery, respectively. The signal intensity (SI) patterns of the repaired tendon on T2-weighted images from the first MRI were classified into three types of heterogeneous high SI with fluid-like bright high foci (type I), heterogeneous high SI without fluid-like bright high foci (type II), and heterogeneous or homogeneous low SI (type III). Interval changes in the SI pattern, tendon thickness, and rotator cuff interval thickness between the two postoperative MRIs were evaluated. The SI patterns on the first MRI were type I or II in 45 tendons (90%) and type III in five (10%). SI decreased significantly on the second MRI (p < 0.050). The mean thickness of repaired tendons and rotator cuff intervals also decreased significantly (p < 0.050). Repaired supraspinatus tendons exhibited high SI in 90% of clinically improving patients on MRI performed during the early postsurgical period. The increased SI and thickness of the repaired tendon decreased on the later MRI, suggesting a gradual healing process rather than a retear.

  4. 面向长周期的交通状态反馈诱导策略%Traffic state feedback guidance strategy under long update intervals

    Institute of Scientific and Technical Information of China (English)

    贺正冰; 关伟

    2013-01-01

      Update intervals for guidance strategies used in variable message signs have to be long due to limitations of detectors and display format of broadcasting guidance information. A guidance strategy is introduced based on the traffic state instead of travel time. A traffic state feedback guidance strategy is obtained by utilizing relative stability of traffic state. A hybrid strategy considering travel time and traffic state is proposed as a solution of conflict between time-varying demand and long intervals. Simulation results show that the traffic state feedback strategy is able to meet the practical requirement both in the stability and accuracy under long update intervals, and the hybrid strategy further improves the accuracy.%  受检测器和诱导信息板显示形式的限制,诱导信息更新周期通常较长。为此,根据备选路径交通状态而非行驶时间制定诱导策略,利用交通状态相对稳定的特点,进一步提出状态反馈诱导策略;为减少长周期与时变交通需求间的矛盾及其他误差,提出了状态与时间反馈策略相结合的混合策略。仿真实验表明,面对长周期时,状态反馈策略可以满足稳定性和准确性的双重要求,混合策略则进一步提高了诱导的准确性。

  5. Self-Adapting Routing Overlay Network for Frequently Changing Application Traffic in Content-Based Publish/Subscribe System

    OpenAIRE

    Meng Chi; Shufen Liu; Changhong Hu

    2014-01-01

    In the large-scale distributed simulation area, the topology of the overlay network cannot always rapidly adapt to frequently changing application traffic to reduce the overall traffic cost. In this paper, we propose a self-adapting routing strategy for frequently changing application traffic in content-based publish/subscribe system. The strategy firstly trains the traffic information and then uses this training information to predict the application traffic in the future. Finally, the strat...

  6. Assessment of histological changes in antemortem gingival tissues fixed at various time intervals: A method of estimation of postmortem interval

    Science.gov (United States)

    Mahalakshmi, V.; Gururaj, N.; Sathya, R.; Sabarinath, T. R.; Sivapathasundharam, B.; Kalaiselvan, S.

    2016-01-01

    Introduction: Conventional methods to estimate the time of death are adequate, but a histological method is yet unavailable to assess postmortem interval (PMI). The autolytic changes that occur in an unfixed antemortem gingival tissue which reflects histologically at an early stage are similar to changes that occur in postmortem tissue. These histological changes can be used and applied in a postmortem tissue as a method to assess PMI. Aims: The aim of the study is to assess the histological changes in a gingival tissue left unfixed for various time intervals and to correlate the findings with duration. Materials and Methods: Sixty gingival tissues obtained from patients following therapeutic extractions, impactions, gingivectomy and crown lengthening procedures were used. Each tissue obtained was divided into two pieces and labeled as “A”, the control group and “ B” the study group. Tissues labeled “A” were fixed in 10% formalin immediately and tissues labeled“B” were placed in closed containers and fixed after 15, 30, 45 min, 1, 2, and 4 h time interval. Of the sixty tissues in the study group “ B”, ten tissues were used for each time interval under investigation. All the fixed tissues were processed, stained, assessed, and analyzed statistically using Pearson correlation and regression analysis. Results: Histological changes appear at 15 min in an unfixed antemortem tissue. At 2 h interval, all layers with few cells in basal cell layer are involved. At 4 h interval, loss of stratification and complete homogenization of cells in the superficial layers with prominent changes in basal layer is evident. There was a positive correlation (<1.0) between the time interval and the appearance of the histological changes. Conclusion: Histological changes such as complete homogenization of cells in superficial layers and loss of epithelial architecture at 4 h in unfixed antemortem tissue may be used as a criterion to estimate PMI, after further studies

  7. Assessment of histological changes in antemortem gingival tissues fixed at various time intervals: A method of estimation of postmortem interval

    Directory of Open Access Journals (Sweden)

    V Mahalakshmi

    2016-01-01

    Full Text Available Introduction: Conventional methods to estimate the time of death are adequate, but a histological method is yet unavailable to assess postmortem interval (PMI. The autolytic changes that occur in an unfixed antemortem gingival tissue which reflects histologically at an early stage are similar to changes that occur in postmortem tissue. These histological changes can be used and applied in a postmortem tissue as a method to assess PMI. Aims: The aim of the study is to assess the histological changes in a gingival tissue left unfixed for various time intervals and to correlate the findings with duration. Materials and Methods: Sixty gingival tissues obtained from patients following therapeutic extractions, impactions, gingivectomy and crown lengthening procedures were used. Each tissue obtained was divided into two pieces and labeled as “A”, the control group and “ B” the study group. Tissues labeled “A” were fixed in 10% formalin immediately and tissues labeled“B” were placed in closed containers and fixed after 15, 30, 45 min, 1, 2, and 4 h time interval. Of the sixty tissues in the study group “ B”, ten tissues were used for each time interval under investigation. All the fixed tissues were processed, stained, assessed, and analyzed statistically using Pearson correlation and regression analysis. Results: Histological changes appear at 15 min in an unfixed antemortem tissue. At 2 h interval, all layers with few cells in basal cell layer are involved. At 4 h interval, loss of stratification and complete homogenization of cells in the superficial layers with prominent changes in basal layer is evident. There was a positive correlation (<1.0 between the time interval and the appearance of the histological changes.Conclusion: Histological changes such as complete homogenization of cells in superficial layers and loss of epithelial architecture at 4 h in unfixed antemortem tissue may be used as a criterion to estimate PMI, after

  8. Cell cycle and cell signal transduction in marine phytoplankton

    Institute of Scientific and Technical Information of China (English)

    LIU Jingwen; JIAO Nianzhi; CAI Huinong

    2006-01-01

    As unicellular phytoplankton, the growth of a marine phytoplankton population results directly from the completion of a cell cycle, therefore, cell-environment communication is an important way which involves signal transduction pathways to regulate cell cycle progression and contribute to growth, metabolism and primary production and respond to their surrounding environment in marine phytoplankton. Cyclin-CDK and CaM/Ca2+ are essentially key regulators in control of cell cycle and signal transduction pathway, which has important values on both basic research and applied biotechnology. This paper reviews progress made in this research field, which involves the identification and characterization of cyclins and cell signal transduction system, cell cycle control mechanisms in marine phytoplankton cells, cell cycle proteins as a marker of a terminal event to estimate the growth rate of phytoplankton at the species level, cell cycle-dependent toxin production of toxic algae and cell cycle progression regulated by environmental factors.

  9. Associations between Recreational and Commuter Cycling, Changes in Cycling, and Type 2 Diabetes Risk

    DEFF Research Database (Denmark)

    Rasmussen, Martin G; Grøntved, Anders; Blond, Kim;

    2016-01-01

    BACKGROUND: Cycling is a recreational activity and mode of commuting with substantial potential to improve public health in many countries around the world. The aim of this study was to examine prospective associations between recreational and commuter cycling, changes in cycling habits, and risk...... to recreational and commuter cycling and changes in cycling habits, with adjustment for a priori known T2D risk factors. During 743,245.4 person-years of follow-up (mean follow-up 14.2 y), 6,779 incident cases of T2D were documented. Multivariable adjusted HRs (95% confidence interval [CI]) were 1, 0.87 (0.82, 0.......80 (0.76, 0.85) for non-cyclists, seasonal cyclists (those cycling only in summer or winter), and those cycling during both summer and winter, respectively. How changes in total cycling from baseline to the second examination affected risk was also investigated, and multivariable adjusted HRs (95% CI...

  10. Communication efficiency and congestion of signal traffic in large-scale brain networks.

    Science.gov (United States)

    Mišić, Bratislav; Sporns, Olaf; McIntosh, Anthony R

    2014-01-01

    The complex connectivity of the cerebral cortex suggests that inter-regional communication is a primary function. Using computational modeling, we show that anatomical connectivity may be a major determinant for global information flow in brain networks. A macaque brain network was implemented as a communication network in which signal units flowed between grey matter nodes along white matter paths. Compared to degree-matched surrogate networks, information flow on the macaque brain network was characterized by higher loss rates, faster transit times and lower throughput, suggesting that neural connectivity may be optimized for speed rather than fidelity. Much of global communication was mediated by a "rich club" of hub regions: a sub-graph comprised of high-degree nodes that are more densely interconnected with each other than predicted by chance. First, macaque communication patterns most closely resembled those observed for a synthetic rich club network, but were less similar to those seen in a synthetic small world network, suggesting that the former is a more fundamental feature of brain network topology. Second, rich club regions attracted the most signal traffic and likewise, connections between rich club regions carried more traffic than connections between non-rich club regions. Third, a number of rich club regions were significantly under-congested, suggesting that macaque connectivity actively shapes information flow, funneling traffic towards some nodes and away from others. Together, our results indicate a critical role of the rich club of hub nodes in dynamic aspects of global brain communication.

  11. Projected future changes in regional seasonal cycles

    Science.gov (United States)

    Arizmendi, Fernando; Barreiro, Marcelo; Dijkstra, Henk

    2015-04-01

    Understanding the consequences of climate change is relevant for social, biological and ecomical interests. Particularly, knowing the potential changes in the seasonal cycle is useful for taking the appropiate actions to prevent adverse circumstances. In this study, we aim to detect future changes in the surface air temperature (SAT) seasonal cycles. We do so by analyzing differences in the response of the SAT field to the solar annual forcing in different scenarios of models of the phase 5 of the Coupled Model Intercomparison Project (CMIP5). With this approach, we are able to find well-localized areas where the temperature cycle change considerably.

  12. The QT interval and cycle length: the influence of atropine, hyoscine and exercise.

    OpenAIRE

    Staniforth, D H

    1983-01-01

    Twenty-seven healthy male subjects of mean age 24.3 +/- 4.0 years and mean weight 74.9 +/- 9.1 kg took part in an investigation to assess the most suitable correction for the QT interval as a function of cardiac cycle length. 547 sets of data points were generated. Atropine 0.6, 1.2 and 1.8 mg, and hyoscine 0.4 and 0.8 mg, and exercise on a bicycle ergometer at power levels of 50-250 watts together with post-exercise values were employed to obtain a range of heart rates. Simultaneous measurem...

  13. Operating regimes of signaling cycles: statics, dynamics, and noise filtering.

    Directory of Open Access Journals (Sweden)

    Carlos Gomez-Uribe

    2007-12-01

    Full Text Available A ubiquitous building block of signaling pathways is a cycle of covalent modification (e.g., phosphorylation and dephosphorylation in MAPK cascades. Our paper explores the kind of information processing and filtering that can be accomplished by this simple biochemical circuit. Signaling cycles are particularly known for exhibiting a highly sigmoidal (ultrasensitive input-output characteristic in a certain steady-state regime. Here, we systematically study the cycle's steady-state behavior and its response to time-varying stimuli. We demonstrate that the cycle can actually operate in four different regimes, each with its specific input-output characteristics. These results are obtained using the total quasi-steady-state approximation, which is more generally valid than the typically used Michaelis-Menten approximation for enzymatic reactions. We invoke experimental data that suggest the possibility of signaling cycles operating in one of the new regimes. We then consider the cycle's dynamic behavior, which has so far been relatively neglected. We demonstrate that the intrinsic architecture of the cycles makes them act--in all four regimes--as tunable low-pass filters, filtering out high-frequency fluctuations or noise in signals and environmental cues. Moreover, the cutoff frequency can be adjusted by the cell. Numerical simulations show that our analytical results hold well even for noise of large amplitude. We suggest that noise filtering and tunability make signaling cycles versatile components of more elaborate cell-signaling pathways.

  14. 无灯控错位交叉口交通流模型研究%Traffic Flow Model for Staggered Intersection without Signal Lamp

    Institute of Scientific and Technical Information of China (English)

    刘小明; 郑淑晖

    2012-01-01

    错位交叉口交通特性研究对于制定合理有效的错位交叉口交通管控策略具有重要意义.针对无灯控错位交叉口交通流间的冲突过程分别建立了相应的元胞自动机行为规则,进而应用上述规则对不同参数设置下的交通流演化过程进行数值模拟,并分析和讨论了主路进口道交通流密度变化对不同路段交通流平均速度的影响.研究结果表明,错位交叉口主路上较小的车流密度也能导致主路进口道及两T型口中间路段发生交通堵塞,每个T型口主路进口道交通流量变化会对另一个T型口主路进口道交通流平均速度产生较大影响,此外,无灯控下的交通堵塞也会呈现周期性的排队-消散过程.上述方法及结果可为错位交叉口实施信号控制提供有意义的指导.%Traffic characteristics investigation of staggered intersection lays the foundation of scientific and reasonable traffic control strategies. This paper first proposes the cellular automaton rules on the basis of the traffic conflict process analysis. Then with these rules, the traffic flow evolution under different parameters is presented by numerical simulations. The relationship between the arterial road traffic flow density and the average speed is explored. It is revealed that low traffic density on the main road of staggered intersections may lead to traffic congestions on the approach of main road and the road between two T-type intersections, and the average speed of traffic flow on each T-type import of main road was affected by the traffic flow changes of the other T-type approaches. Moreover, the traffic congestion on intersection without signal lamp is presented as a periodically queuing-dissipates process. The above methods and results provide meaningful guidance for traffic management and control implementation of staggered intersections without signal lamp.

  15. Assessment of histological changes in antemortem gingival tissues fixed at various time intervals: A method of estimation of postmortem interval

    Science.gov (United States)

    Mahalakshmi, V.; Gururaj, N.; Sathya, R.; Sabarinath, T. R.; Sivapathasundharam, B.; Kalaiselvan, S.

    2016-01-01

    Introduction: Conventional methods to estimate the time of death are adequate, but a histological method is yet unavailable to assess postmortem interval (PMI). The autolytic changes that occur in an unfixed antemortem gingival tissue which reflects histologically at an early stage are similar to changes that occur in postmortem tissue. These histological changes can be used and applied in a postmortem tissue as a method to assess PMI. Aims: The aim of the study is to assess the histological changes in a gingival tissue left unfixed for various time intervals and to correlate the findings with duration. Materials and Methods: Sixty gingival tissues obtained from patients following therapeutic extractions, impactions, gingivectomy and crown lengthening procedures were used. Each tissue obtained was divided into two pieces and labeled as “A”, the control group and “ B” the study group. Tissues labeled “A” were fixed in 10% formalin immediately and tissues labeled“B” were placed in closed containers and fixed after 15, 30, 45 min, 1, 2, and 4 h time interval. Of the sixty tissues in the study group “ B”, ten tissues were used for each time interval under investigation. All the fixed tissues were processed, stained, assessed, and analyzed statistically using Pearson correlation and regression analysis. Results: Histological changes appear at 15 min in an unfixed antemortem tissue. At 2 h interval, all layers with few cells in basal cell layer are involved. At 4 h interval, loss of stratification and complete homogenization of cells in the superficial layers with prominent changes in basal layer is evident. There was a positive correlation (PMI, after further studies on postmortem tissues.

  16. Reduction of the air traffic's contribution to climate change: A REACT4C case study

    OpenAIRE

    Grewe, V; Champougny, T.; Matthes, Sigrun; Frömming, Christine; Brinkop, Sabine; Soevde, Amund; Irvine, Emma A.; Halscheidt, Lucia

    2014-01-01

    Air traffic alters the atmospheric composition and thereby contributes to climate change. Here we investigate the trans-Atlantic air traffic for one specific winter day and analyse, which routing changes were required to achieve a reduction in the air traffic’s contribution to climate change. We have applied an atmosphere-chemistry model to calculate so-called five dimensional climate cost functions (CCF), which describe the climate effect of a locally confined emission. The five dimensions r...

  17. A new traffic model on compulsive lane-changing caused by off-ramp

    Science.gov (United States)

    Xiao-He, Liu; Hung-Tang, Ko; Ming-Min, Guo; Zheng, Wu

    2016-04-01

    In the field of traffic flow studies, compulsive lane-changing refers to lane-changing (LC) behaviors due to traffic rules or bad road conditions, while free LC happens when drivers change lanes to drive on a faster or less crowded lane. LC studies based on differential equation models accurately reveal LC influence on traffic environment. This paper presents a second-order partial differential equation (PDE) model that simulates both compulsive LC behavior and free LC behavior, with lane-changing source terms in the continuity equation and a lane-changing viscosity term in the momentum equation. A specific form of this model focusing on a typical compulsive LC behavior, the ‘off-ramp problem’, is derived. Numerical simulations are given in several cases, which are consistent with real traffic phenomenon. Project supported by the National Natural Science Foundation of China (Grant Nos. 11002035 and 11372147).

  18. The Preventive Signaling Maintenance Crew Scheduling Problem for European Railway Traffic Management system (ERTMS)

    DEFF Research Database (Denmark)

    Mohammad Pour, Shahrzad; Stidsen, Thomas Jacob Riis; Rasmussen, Kourosh Marjani

    , the western part of Denmark. This case is particularly interesting, since the entire railway signalling system is currently being upgraded to the new European Railway Traffic Management System (ERTMS) standard. The new signals need continuous maintenance and in this article we plan the distribution of crew......A railway system is a large and complex infrastructure, which requires continuous maintenance in order to function correctly. Proper maintenance is critical but can also be costly. In this paper we consider the practical case of planning the preventive maintenance of railway signals in Jutland...... and also schedule their daily tasks. We formulate the problem as a multi depot vehicle routing problem with time windows and synchronization constraints, in a multi-day time schedule. We solve the problem for large realistic instances by introducing a constructive stage-wise algorithm. Experimental results...

  19. Helioseismic Solar Cycle Changes and Splitting Coefficients

    Indian Academy of Sciences (India)

    S. C. Tripathy; Kiran Jain; A. Bhatnagar

    2000-09-01

    Using the GONG data for a period over four years, we have studied the variation of frequencies and splitting coefficients with solar cycle. Frequencies and even-order coefficients are found to change significantly with rising phase of the solar cycle. We also find temporal variations in the rotation rate near the solar surface.

  20. Solving a signalized traffic intersection problem with an hyperbolic penalty function

    Science.gov (United States)

    Melo, Teófilo; Monteiro, M. Teresa T.; Matias, João

    2012-09-01

    Mathematical Program with Complementarity Constraints (MPCC) finds many applications in fields such as engineering design, economic equilibrium and mathematical programming theory itself. A queueing system model resulting from a single signalized intersection regulated by pre-timed control in traffic network is considered. The model is formulated as an MPCC problem. A MATLAB implementation based on an hyperbolic penalty function is used to solve this practical problem, computing the total average waiting time of the vehicles in all queues and the green split allocation. The problem was codified in AMPL.

  1. Influence of Wilbraham-Gibbs Phenomenon on Digital Stochastic Measurement of EEG Signal Over an Interval

    Directory of Open Access Journals (Sweden)

    Sovilj P.

    2014-10-01

    Full Text Available Measurement methods, based on the approach named Digital Stochastic Measurement, have been introduced, and several prototype and small-series commercial instruments have been developed based on these methods. These methods have been mostly investigated for various types of stationary signals, but also for non-stationary signals. This paper presents, analyzes and discusses digital stochastic measurement of electroencephalography (EEG signal in the time domain, emphasizing the problem of influence of the Wilbraham-Gibbs phenomenon. The increase of measurement error, related to the Wilbraham-Gibbs phenomenon, is found. If the EEG signal is measured and measurement interval is 20 ms wide, the average maximal error relative to the range of input signal is 16.84 %. If the measurement interval is extended to 2s, the average maximal error relative to the range of input signal is significantly lowered - down to 1.37 %. Absolute errors are compared with the error limit recommended by Organisation Internationale de Métrologie Légale (OIML and with the quantization steps of the advanced EEG instruments with 24-bit A/D conversion

  2. Cycle-by-Cycle Queue Length Estimation for Signalized Intersections Using Multi-Source Data

    Institute of Scientific and Technical Information of China (English)

    Zhongyu Wang; Qing Cai; Bing Wu; Yinhai Wang; Linbo Li

    2015-01-01

    In order to estimate vehicular queue length at signalized intersections accurately and overcome the shortcomings and restrictions of existing studies especially those based on shockwave theory, a new methodology is presented for estimating vehicular queue length using data from both point detectors and probe vehicles. The methodology applies the shockwave theory to model queue evolution over time and space. Using probe vehicle locations and times as well as point detector measured traffic states, analytical formulations for calculating the maximum and minimum ( residual) queue length are developed. The proposed methodology is verified using ground truth data collected from numerical experiments conducted in Shanghai, China. It is found that the methodology has a mean absolute percentage error of 17�09%, which is reasonably effective in estimating the queue length at traffic signalized intersections. Limitations of the proposed models and algorithms are also discussed in the paper.

  3. The invariance of current energy fourier spectrum of discrete real signals on finite intervals

    Directory of Open Access Journals (Sweden)

    Ponomarev V. A.

    2014-02-01

    Full Text Available Digital spectral analysis of signals based on DFT has a number of advantages. However, the transition from analog to digital methods and techniques is accompanied by a number of undesirable effects. Signals in each subject area usually have their own specifics. Therefore, it is necessary to study these effects in applications of spectral Fourier analysis. Such research is important for three reasons. Firstly, DFT properties are accurate, have their own specificity and significantly differ from the properties of the Fourier transform of continuous signals. Secondly, signals in each subject area have their own specificity. Thirdly, researchers often have prevailing knowledge in some particular domain, rather than in the field of digital signal processing techniques. As a result, in practice, some of the processes and effects arising in applications of digital spectral analysis, unfortunately, escape the attention of researchers which can result in erroneous conclusions. The paper deals with the problems of measuring Fourier spectrum of signals in the base of discrete exponential functions. Methods and algorithms of sliding measurements of energy Fourier spectrum of signals on finite intervals were described. The invariance of current energy Fourier spectrum to moving discrete real signals (which are not periodic were investigated. The authors identify a new effect of digital spectral analysis — the effect of non-invariance of the current energy Fourier spectrum. Theoretical and practical results of analysis of invariance of current energy Fourier spectrum of tonal components are shown. The conducted studies allow us: — to see in a new light the measurement results on finite intervals of current Fourier spectrum and the current energy Fourier spectra of signals; give a numerical estimate of the non-invariance of the current energy Fourier spectrum of real tonal components. — to increase the effectiveness of digital spectral analysis in its

  4. Climate effect of ozone changes caused by present and future air traffic

    Energy Technology Data Exchange (ETDEWEB)

    Ponater, M.; Sausen, R.; Feneberg, B. [DLR Deutsches Zentrum fuer Luft- und Raumfahrt e.V., Wessling (Germany). Inst. fuer Physik der Atmosphaere; Roeckner, E. [Max-Planck-Institut fuer Meteorologie, Hamburg (Germany)

    1998-08-01

    The potential of aircraft-induced ozone changes to significantly enhance the climate impact of air traffic due to CO{sub 2}-emissions is investigated by means of simulations with an atmospheric general circulation model, coupled to a mixed layer ocean model. Results from several numerical experiments are presented, based on ozone increase patterns for 1992 aviation and on a future scenario for the year 2015. The climate signal is statistically significant for both time slices. Its strength is of comparable magnitude to that arising from aircraft CO{sub 2} emissions, thus meaning a nonnegligible contribution to the total effect. There are indications of a characteristic signature of the aircraft ozone related temperature response pattern, distinctly different from that typically associated with the increase of a well-mixed greenhouse gas. Likewise, the climate sensitivity to nonuniform ozone changes including a strong concentration perturbation at the tropopause appears to he higher than the climate sensitivity to uniform changes of a greenhouse gas. In a hierarchy of experiments based on an aircraft-related ozone perturbation with fixed structure (but increasing amplitude), the climate signal depends in a nonlinear way from the radiative forcing. (orig.) 44 refs.

  5. Dangerous drivers foster social dilemma structures hidden behind a traffic flow with lane changes

    Science.gov (United States)

    Tanimoto, Jun; Fujiki, Takuya; Wang, Zhen; Hagishima, Aya; Ikegaya, Naoki

    2014-11-01

    Motivated by the fact that there are quite a few ill-mannered drivers who disregard traffic rules concerning lane-changing and maximum speed, we investigated an interesting question: whether or not social dilemma structures can be formed from a frequent dangerous lane-changing attitude in a typical traffic flow without any explicit bottlenecks. In our model system, two classes of driver-agents coexist: C agents (cooperative strategy) always keep to traffic regulations with respect to lane-changing and speed, while D agents (defective strategy) disregard them to move ahead. In relatively high-density flows, such as the metastable and high-density phases, we found structures that correspond to either n-person Prisoner's Dilemma (n-PD) games or to quasi-PD games. In these situations, existing ill-mannered drivers create heavy traffic jams that reduce social efficiency.

  6. Road crossing behavior under traffic light conflict: Modulating effects of green light duration and signal congruency.

    Science.gov (United States)

    Lange, Florian; Haiduk, Michael; Boos, Moritz; Tinschert, Peter; Schwarze, Anke; Eggert, Frank

    2016-10-01

    A large number of pedestrians and cyclists regularly ignore the traffic lights to cross the road illegally. In a recent analysis, illegal road crossing behavior has been shown to be enhanced in the presence of incongruent stimulus configurations. Pedestrians and cyclists are more likely to cross against a red light when exposed to an irrelevant conflicting green light. Here, we present experimental and observational data on the factors moderating the risk associated with incongruent traffic lights. In an observational study, we demonstrated that the conflict-related increase in illegal crossing rates is reduced when pedestrian and cyclist green light periods are long. In a laboratory experiment, we manipulated the color of the irrelevant signals to expose participants to different degrees of incongruency. Results revealed that individuals' performance gradually varied as a function of incongruency, suggesting that the negative impact of a conflicting green light can be reduced by slightly adjusting its color. Our findings highlight that the observation of real-world behavior at intersections and the experimental analysis of psychological processes under controlled laboratory conditions can complement each other in identifying risk factors of risky road crossing behavior. Based on this combination, our study elaborates on promising measures to improve safety at signalized intersections. PMID:27474874

  7. A Model for Capacity Considering the Interference by Pedestrian Traffic at Signal Intersections

    Institute of Scientific and Technical Information of China (English)

    Yixin Chen; Yulong He; Xiaoduan Sun

    2016-01-01

    The capacity is impacted badly by pedestrians’ violation behavior at signal intersections. In order to quantify the impact, the time⁃headway and the vehicular speed from start⁃up to reach the stable saturation flow with and without pedestrian traffic are used as the direct measurements. Using the statistical analysis, the time⁃headway of saturation flow is mainly affected by the position of pedestrians and the degree of pedestrians ’ influence is classified into four levels. Then the speed⁃time profile for the vehicular acceleration at each level is fitted by Curve Fitting Software. Based on the effect to the time⁃headway and acceleration time, the model of capacity influenced by pedestrians is established and the influence is quantified, which enriches the fundamental theory of traffic engineering. The result shows that the vehicular capacity can be decreased by 14%at the worst case ( level I ) . The conclusions obtained in this paper are valuable for better management of the signal intersection.

  8. A Simulation-Based Framework for the Cooperation of VMS Travel Guidance and Traffic Signal Control

    Directory of Open Access Journals (Sweden)

    Meng Li

    2014-01-01

    Full Text Available Nowadays, both travel guidance systems and traffic signal control systems are quite common for urban traffic management. In order to achieve collaborative effect, different models had been proposed in the last two decades. In recent years, with the development of variable message sign (VMS technology, more and more VMS panels are installed on major arterials to provide highly visible and concise graphs or text messages to drivers, especially in developing countries. To discover drivers’ responses to VMS, we establish a drivers’ en route diversion model according to a stated-preference survey. Basically, we proposed a cooperative mechanism and systematic framework of VMS travel guidance and major arterials signal operations. And then a two-stage nested optimization problem is formulated. To solve this optimization problem, a simulation-based optimization method is adopted to optimize the cooperative strategies with TRANSIMS. The proposed method is applied to the real network of Tianjin City comprising of 30 nodes and 46 links. Simulations show that this new method could well improve the network condition by 26.3%. And analysis reveals that GA with nested dynamic programming is an effective technique to solve the optimization problem.

  9. 47 CFR 73.646 - Telecommunications Service on the Vertical Blanking Interval and in the Visual Signal.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Telecommunications Service on the Vertical Blanking Interval and in the Visual Signal. 73.646 Section 73.646 Telecommunication FEDERAL COMMUNICATIONS....646 Telecommunications Service on the Vertical Blanking Interval and in the Visual Signal....

  10. Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation.

    Science.gov (United States)

    Klip, Amira; Sun, Yi; Chiu, Tim Ting; Foley, Kevin P

    2014-05-15

    Skeletal muscle is the major tissue disposing of dietary glucose, a function regulated by insulin-elicited signals that impart mobilization of GLUT4 glucose transporters to the plasma membrane. This phenomenon, also central to adipocyte biology, has been the subject of intense and productive research for decades. We focus on muscle cell studies scrutinizing insulin signals and vesicle traffic in a spatiotemporal manner. Using the analogy of an integrated circuit to approach the intersection between signal transduction and vesicle mobilization, we identify signaling relays ("software") that engage structural/mechanical elements ("hardware") to enact the rapid mobilization and incorporation of GLUT4 into the cell surface. We emphasize how insulin signal transduction switches from tyrosine through lipid and serine phosphorylation down to activation of small G proteins of the Rab and Rho families, describe key negative regulation step of Rab GTPases through the GTPase-activating protein activity of the Akt substrate of 160 kDa (AS160), and focus on the mechanical effectors engaged by Rabs 8A and 10 (the molecular motor myosin Va), and the Rho GTPase Rac1 (actin filament branching and severing through Arp2/3 and cofilin). Finally, we illustrate how actin filaments interact with myosin 1c and α-Actinin4 to promote vesicle tethering as preamble to fusion with the membrane.

  11. The Impact of Gasoline Price Changes on Traffic Safety: a Time Geography Explanation.

    OpenAIRE

    Guangqing Chi; Jeremy Porter; Arthur Cosby; David Levinson

    2009-01-01

    The impact of gasoline price changes on traffic safety has received increasing attention in empirical studies. However, this important relationship has not been explained within a conceptual or theoretical framework. In this study, we examine this relationship within a time geography framework in an attempt to understand the effect of time-varying fluctuations in gasoline prices and their relationship to traffic safety in a case study of Mississippi from April 2004 to December 2008. We furthe...

  12. Change in Neighborhood Traffic Safety: Does It Matter in Terms of Physical Activity?

    OpenAIRE

    Birthe Jongeneel-Grimen; Wim Busschers; Mariël Droomers; van Oers, Hans A.M.; Karien Stronks; Kunst, Anton E.

    2013-01-01

    BACKGROUND: There is limited evidence on the causality of previously observed associations between neighborhood traffic safety and physical activity (PA). This study aims to contribute to this evidence by assessing the extent to which changes over time in neighborhood traffic safety were associated with PA. METHODS: Data were accessed from the national survey Netherlands Housing Research for 2006 and 2009. The two samples of in total 57,092 Dutch residents aged 18-84 years lived in 320 neighb...

  13. Coordinated control model of regional traffic signals%交通区域协调控制模型

    Institute of Scientific and Technical Information of China (English)

    刘芹; 徐建闽

    2012-01-01

    为提高交通区域通行效率,构建了适合各种交通状态的区域信号协调控制模型。以区域交叉口总排队车辆数与区域总输出车辆数为性能指标,考虑上下周期排队车辆数、各交叉口闭合相位差与有效绿灯时间,建立了模型约束条件。利用粒子群算法初始化有效绿灯时间与滞留车辆数,采用模拟退火算法求解有效绿灯时间,在不同交通状态下对某交叉口路网进行了仿真。仿真结果表明:与TRANSYT模型相比,低峰时段,采用本文模型排队车辆数降低了5.3%,区域总输出车辆数增加了5.5%;高峰时段,排队车辆数降低了17.9%,区域总输出车辆数增加了33.4%。交叉口的信号方案优化结果表明:与TRANSYT模型相比,采用本文模型时,各车道饱和度均降低,平均为1.8%,最大排队车辆数平均降低2.9%。分析结果表明:本文模型在各种交通状态下都是有效的,特别是在高峰状态下,控制效果优于TRANSYT模型。%In order to improve the traffic efficiency of traffic area, a coordinated control model of regional signals was constructed under all kinds of traffic conditions. The total queue vehicle number and the total output vehicle number of regional intersection were used as performance indexes of the model. The constraint conditions of the model were established by considering the variable relationship of the adjacent cycle queue vehicle numbers, closed phase difference of intersections and effective green time. The effective green time and waiting vehicle number were initialized by particle swarm algorithm. The effective green time was solved by simulated annealing algorithm. The road network of a certain intersection was simulated under different traffic states. Simulation result shows that the queue vehicle number reduces by 5.3% and the total output vehicle number of region increases by 5.5% in low peak period compared with the TRANSYT model. The queue vehicle number reduces by

  14. Carbon cycle feedbacks and future climate change.

    Science.gov (United States)

    Friedlingstein, Pierre

    2015-11-13

    Climate and carbon cycle are tightly coupled on many timescales, from interannual to multi-millennial timescales. Observations always evidence a positive feedback, warming leading to release of carbon to the atmosphere; however, the processes at play differ depending on the timescales. State-of-the-art Earth System Models now represent these climate-carbon cycle feedbacks, always simulating a positive feedback over the twentieth and twenty-first centuries, although with substantial uncertainty. Recent studies now help to reduce this uncertainty. First, on short timescales, El Niño years record larger than average atmospheric CO2 growth rate, with tropical land ecosystems being the main drivers. These climate-carbon cycle anomalies can be used as emerging constraint on the tropical land carbon response to future climate change. Second, centennial variability found in last millennium records can be used to constrain the overall global carbon cycle response to climatic excursions. These independent methods point to climate-carbon cycle feedback at the low-end of the Earth System Models range, indicating that these models overestimate the carbon cycle sensitivity to climate change. These new findings also help to attribute the historical land and ocean carbon sinks to increase in atmospheric CO2 and climate change. PMID:26438284

  15. Fourier spectrum and phases for a signal in a finite interval

    Science.gov (United States)

    Belmont, Gérard; Dorville, Nicolas; Sahraoui, Fouad; Rezeau, Laurence

    2015-04-01

    When investigating the physics of turbulent media, as the solar wind or the magnetosheath plasmas, obtaining accurate Fourier spectra and phases is a crucial issue. For the different fields, the spectra allow in particular verifying whether one or several power laws can be determined in different frequency ranges. Accurate phases are necessary as well for all the "higher order statistics" studies in Fourier space, the coherence ones and for the polarization studies. Unfortunately, the Fourier analysis is not unique for a finite time interval of duration T: the frequencies lower than 1/T have a large influence on the result, which can hardly be controlled. This unknown "trend" has in particular the effect of introducing jumps at the edges of the interval, for the function under study itself, as well as for all its derivatives. The Fourier transform obtained directly by FFT (Fast Fourier Transform) is generally much influenced by these effects and cannot be used without care for wide band signals. The interference between the jumps and the signal itself provide in particular characteristic "hairs" on the spectrum, which are clearly visible on it with df≈1/T. These fluctuations are usually eliminated by smoothing the spectrum, or by averaging several successive spectra. Nevertheless, such treatments introduce uncertainties on the spectral laws (the phases being anyway completely lost). Windowing is also a method currently used to suppress or decrease the jumps, but it modifies the signal (the windowed trend has a spectrum, which is convolved with the searched one) and the phases are generally much altered. Here, we present a new data processing technique to circumvent these difficulties. It takes advantage of the fact that the signal is generally not unknown out of the interval under study: the complete signal is tapered to this interval of interest thanks to a new window function, sharp but not square. This window function is chosen such that the spectrum obtained

  16. Lethal pedestrian--passenger car collisions in Berlin. Changed injury patterns in two different time intervals.

    Science.gov (United States)

    Ehrlich, Edwin; Tischer, Anja; Maxeiner, H

    2009-04-01

    To expand the passive safety of automobiles protecting traffic participants technological innovations were done in the last decades. Objective of our retrospective analysis was to examine if these technical modifications led to a clearly changed pattern of injuries of pedestrians whose death was caused by the accidents. Another reduction concerns the exclusion of injured car passengers--only pedestrians walking or standing at the moment of collision were included. We selected time intervals 1975-1985 and 1991-2004 (=years of construction of the involved passenger cars). The cars were classified depending on their frontal construction in types as presented by Schindler et al. [Schindler V, Kühn M, Weber S, Siegler H, Heinrich T. Verletzungsmechanismen und Wirkabschätzungen der Fahrzegfrontgestaltung bei Pkw-Fussgänger-Kollisionen. Abschlussbericht im Auftrag der Deutschen Versicherungswirtschaft e.V. TU-Berlin Fachgebiet Kraftfahrzeuge (GDV) 2004:36-40]. In both periods more than 90% of all cars were from the usual types small/medium/large class. Hundred and thirty-four autopsy records of such cases from Department of Forensic Medicine (Charité Berlin) data were analysed. The data included technical information of the accidents and vehicles and the external and internal injuries of the victims. The comparison of the two periods showed a decrease of serious head injuries and femoral fractures but an increase of chest-, abdominal and pelvic injuries. This situation could be explained by an increased occurrence of soft-face-constructions and changed front design of modern passenger cars, resulting in a favourable effects concerning head impact to the car during accident. Otherwise the same kinetic energy was transferred to the (complete) victim - but because of a displacement of main focus of impact the pattern of injuries modified (went distally).

  17. Air Traffic Management Technology Demostration Phase 1 (ATD) Interval Management for Near-Term Operations Validation of Acceptability (IM-NOVA) Experiment

    Science.gov (United States)

    Kibler, Jennifer L.; Wilson, Sara R.; Hubbs, Clay E.; Smail, James W.

    2015-01-01

    The Interval Management for Near-term Operations Validation of Acceptability (IM-NOVA) experiment was conducted at the National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC) in support of the NASA Airspace Systems Program's Air Traffic Management Technology Demonstration-1 (ATD-1). ATD-1 is intended to showcase an integrated set of technologies that provide an efficient arrival solution for managing aircraft using Next Generation Air Transportation System (NextGen) surveillance, navigation, procedures, and automation for both airborne and ground-based systems. The goal of the IMNOVA experiment was to assess if procedures outlined by the ATD-1 Concept of Operations were acceptable to and feasible for use by flight crews in a voice communications environment when used with a minimum set of Flight Deck-based Interval Management (FIM) equipment and a prototype crew interface. To investigate an integrated arrival solution using ground-based air traffic control tools and aircraft Automatic Dependent Surveillance-Broadcast (ADS-B) tools, the LaRC FIM system and the Traffic Management Advisor with Terminal Metering and Controller Managed Spacing tools developed at the NASA Ames Research Center (ARC) were integrated into LaRC's Air Traffic Operations Laboratory (ATOL). Data were collected from 10 crews of current 757/767 pilots asked to fly a high-fidelity, fixed-based simulator during scenarios conducted within an airspace environment modeled on the Dallas-Fort Worth (DFW) Terminal Radar Approach Control area. The aircraft simulator was equipped with the Airborne Spacing for Terminal Area Routes (ASTAR) algorithm and a FIM crew interface consisting of electronic flight bags and ADS-B guidance displays. Researchers used "pseudo-pilot" stations to control 24 simulated aircraft that provided multiple air traffic flows into the DFW International Airport, and recently retired DFW air traffic controllers served as confederate Center, Feeder, Final

  18. Iterative Learning Control Approach for Signaling Split in Urban Traffic Networks with Macroscopic Fundamental Diagrams

    Directory of Open Access Journals (Sweden)

    Fei Yan

    2015-01-01

    Full Text Available Recent analysis of field experiments in cities revealed that a macroscopic fundamental diagram (MFD relating network outflow and network vehicle accumulation exists in the urban traffic networks. It has been further confirmed that an MFD is well defined if the network has regular network topology and homogeneous spatial distribution of vehicle accumulation. However, many real urban networks have different levels of heterogeneity in the spatial distribution of vehicle accumulation. In order to improve the mobility in heterogeneously congested networks, we propose an iterative learning control approach for signaling split, which aims at distributing the accumulation in the networks as homogeneously as possible and ensuring the networks have a larger outflow. The asymptotic convergence of the proposed approach is proved by rigorous analysis and the effectiveness is further demonstrated by extensive simulations.

  19. 路口交通流不均衡饱和时的交通信号控制%Traffic Flow Equilibrium Saturation in Traffic Signal Control

    Institute of Scientific and Technical Information of China (English)

    李雪佳

    2012-01-01

    Aiming at the existing intersection queue, and different directions of traffic flow is not balanced, queue length sum minimum sum of traffic flow model are built, and 2 kinds of optimization of signal timing control strategy are presented by using the optimal control theory and algorithms.%针对交叉路口存在排队车辆,且不同方向上的交通流不均衡,建立排队长度总和达到最小的交通流模型,利用最优控制理论和算法给出两种优化的信号配时控制策略。

  20. Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners.

    Science.gov (United States)

    Ishiki, Manabu; Klip, Amira

    2005-12-01

    Glucose transporter (GLUT) 4 is the major glucose transporter of muscle and adipose cells, exquisitely regulated by insulin through posttranslational events. Twenty years after the seminal observations that GLUT4 levels rapidly rise at the plasma membrane (PM) and drop in endomembranes in response to an acute insulin challenge, we are still mapping the intracellular traffic of the transporter and the regulatory events that insulin unleashes. Newly synthesized GLUT4 enters an insulin-responsive compartment aided by GGA2 (an Arf-binding protein). In cultured adipocytes and myocytes, GLUT4 concentrates in a perinuclear pole through participation of microtubules and the EHD1 Eps15 homology domain-containing protein 1. In the absence of stimuli, GLUT4 distributes between recycling endosomes and the insulin-responsive compartment. A handful of proteins that bind to GLUT4 appear to regulate its half-life (e.g. Ubc9) and tethering within endomembranes (e.g. TUG). Insulin-derived signals promote not only GLUT4 mobilization toward the PM but also its traffic between endosomal compartments and internalization from the PM. Class IA phosphatidylinositol (PI) 3-kinase plays a pivotal role at several steps of GLUT4 mobilization. The PI 3-kinase --> atypical PKC and --> Akt/PKB --> AS160 signaling cascades are major regulators of GLUT4 exocytosis aided by small GTPases. At the cell periphery, GLUT4-containing vesicles tether, dock, and fuse with the PM assisted by the exocyst complex followed by engagement of a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex [with vesicle-associated membrane protein (VAMP)2 as the vesicular (v)-SNARE and soluble NSF-attachment protein (SNAP)23 and syntaxin4 as target (t)-SNAREs] regulated by the accessory proteins Munc18c, Synip and Tomosyn. Vesicle tethering and fusion are regulated by insulin through input from class IA PI 3-kinase. PMID:16150904

  1. Solar spectral irradiance changes during cycle 24

    Energy Technology Data Exchange (ETDEWEB)

    Marchenko, S. V.; DeLand, M. T. [Also at NASA/Goddard Space Flight Center, Greenbelt, MD, USA. (United States)

    2014-07-10

    We use solar spectra obtained by the Ozone Monitoring Instrument (OMI) on board the Aura satellite to detect and follow long-term (years) and short-term (weeks) changes in the solar spectral irradiance (SSI) in the 265-500 nm spectral range. During solar Cycle 24, in the relatively line-free regions the SSI changed by ∼0.6% ± 0.2% around 265 nm. These changes gradually diminish to 0.15% ± 0.20% at 500 nm. All strong spectral lines and blends, with the notable exception of the upper Balmer lines, vary in unison with the solar 'continuum'. Besides the lines with strong chromospheric components, the most involved species include Fe I blends and all prominent CH, NH, and CN spectral bands. Following the general trend seen in the solar 'continuum', the variability of spectral lines also decreases toward longer wavelengths. The long-term solar cycle SSI changes are closely, to within the quoted 0.1%-0.2% uncertainties, matched by the appropriately adjusted short-term SSI variations derived from the 27 day rotational modulation cycles. This further strengthens and broadens the prevailing notion about the general scalability of the UV SSI variability to the emissivity changes in the Mg II 280 nm doublet on timescales from weeks to years. We also detect subtle deviations from this general rule: the prominent spectral lines and blends at λ ≳ 350 nm show slightly more pronounced 27 day SSI changes when compared to the long-term (years) trends. We merge the solar data from Cycle 21 with the current Cycle 24 OMI and GOME-2 observations and provide normalized SSI variations for the 170-795 nm spectral region.

  2. Estimated Aerobic Capacity Changes in Adolescents with Obesity Following High Intensity Interval Exercise

    Directory of Open Access Journals (Sweden)

    Brooke E. Starkoff

    2014-07-01

    Full Text Available Vigorous aerobic exercise may improve aerobic capacity (VO2max and cardiometabolic profiles in adolescents with obesity, independent of changes to weight. Our aim was to assess changes in estimated VO2max in obese adolescents following a 6-week exercise program of varying intensities. Adolescents with obesity were recruited from an American mid-west children’s hospital and randomized into moderate exercise (MOD or high intensity interval exercise (HIIE groups for a 6-week exercise intervention, consisting of cycle ergometry for 40 minutes, 3 days per week. Heart rate was measured every two minutes during each exercise session.  Estimated VO2max measured via Åstrand cycle test, body composition, and physical activity (PA enjoyment evaluated via questionnaire were assessed pre/post-intervention. Twenty-seven adolescents (age 14.7±1.5; 17 female, 10 male completed the intervention. Estimated VO2max increased only in the HIIE group (20.0±5.7 to 22.7±6.5 ml/kg/min, p=0.015. The HIIE group also demonstrated increased PA enjoyment, which was correlated with average heart rate achieved during the intervention (r=0.55; p=0.043. Six weeks of HIIE elicited improvements to estimated VO2max in adolescents with obesity. Furthermore, those exercising at higher heart rates demonstrated greater PA enjoyment, implicating enjoyment as an important determinant of VO2max, specifically following higher intensity activities.

  3. Effects of acute sprint interval cycling and energy replacement on postprandial lipemia.

    Science.gov (United States)

    Freese, Eric C; Levine, Ari S; Chapman, Donald P; Hausman, Dorothy B; Cureton, Kirk J

    2011-12-01

    High postprandial blood triglyceride (TG) levels increase cardiovascular disease risk. Exercise interventions may be effective in reducing postprandial blood TG. The purpose of this study was to determine the effects of sprint interval cycling (SIC), with and without replacement of the energy deficit, on postprandial lipemia. In a repeated-measures crossover design, six men and six women participated in three trials, each taking place over 2 days. On the evening of the first day of each trial, the participants either did SIC without replacing the energy deficit (Ex-Def), did SIC and replaced the energy deficit (Ex-Bal), or did not exercise (control). SIC was performed on a cycle ergometer and involved four 30-s all-out sprints with 4-min active recovery. In the morning of day 2, responses to a high-fat meal were measured. Venous blood samples were collected in the fasted state and at 0, 30, 60, 120, and 180 min postprandial. There was a trend toward a reduction with treatment in fasting TG (P = 0.068), but no significant treatment effect for fasting insulin, glucose, nonesterified fatty acids, or betahydroxybutryrate (P > 0.05). The postprandial area under the curve (mmol·l(-1)·3 h(-1)) TG response was significantly lower in Ex-Def (21%, P = 0.006) and Ex-Bal (10%, P = 0.044) than in control, and significantly lower in Ex-Def (12%, P = 0.032) than in Ex-Bal. There was no treatment effect (P > 0.05) observed for area under the curve responses of insulin, glucose, nonesterified fatty acids, or betahydroxybutryrate. SIC reduces postprandial lipemia, but the energy deficit alone does not fully explain the decrease observed.

  4. Algorithm for automatic detection of the cardiovascular parameter PR-interval from LDV-velocity signals

    Science.gov (United States)

    Mignanelli, Laura; Rembe, Christian

    2016-06-01

    Laser-Doppler-vibrometry (LDV) is broadly employed in mechanical engineering but it has been demonstrated by several researchers that the technique has also large potential in biomedical applications. In particular, the detection of several vital parameters (heart rate, heart rate variability, respiration period) is known as optical vibrocardiography - VBCG. Recent studies have demonstrated the possibility of a reliable detection of the PR-interval (time between atria and ventricle contractions) and classification of the different types of atrioventricular (AV) blocks from this velocity signals. In this work, an algorithm for the localization of the vibrations generated by atrial contraction for the detection of the PR-interval in VBCG acquired on the thorax is presented. The determination of the time point of a heart beat can be extracted easily because it generates an unambiguous maximal velocity peak in the time data. Extracting the contraction of the atrium is more challenging because it is a characteristic signature with an amplitude at the magnitude of the signal disturbances. We compare different approaches of a cost function for the determination of the time point of the atria-contraction signature as well as different optimization algorithms to find the correct PR-time.

  5. Self-Adapting Routing Overlay Network for Frequently Changing Application Traffic in Content-Based Publish/Subscribe System

    Directory of Open Access Journals (Sweden)

    Meng Chi

    2014-01-01

    Full Text Available In the large-scale distributed simulation area, the topology of the overlay network cannot always rapidly adapt to frequently changing application traffic to reduce the overall traffic cost. In this paper, we propose a self-adapting routing strategy for frequently changing application traffic in content-based publish/subscribe system. The strategy firstly trains the traffic information and then uses this training information to predict the application traffic in the future. Finally, the strategy reconfigures the topology of the overlay network based on this predicting information to reduce the overall traffic cost. A predicting path is also introduced in this paper to reduce the reconfiguration numbers in the process of the reconfigurations. Compared to other strategies, the experimental results show that the strategy proposed in this paper could reduce the overall traffic cost of the publish/subscribe system in less reconfigurations.

  6. Tunable Signal Processing through a Kinase Control Cycle: the IKK Signaling Node

    Science.gov (United States)

    Behar, Marcelo; Hoffmann, Alexander

    2013-01-01

    The transcription factor NFκB, a key component of the immune system, shows intricate stimulus-specific temporal dynamics. Those dynamics are thought to play a role in controlling the physiological response to cytokines and pathogens. Biochemical evidence suggests that the NFκB inducing kinase, IKK, a signaling hub onto which many signaling pathways converge, is regulated via a regulatory cycle comprising a poised, an active, and an inactive state. We hypothesize that it operates as a modulator of signal dynamics, actively reshaping the signals generated at the receptor proximal level. Here we show that a regulatory cycle can function in at least three dynamical regimes, tunable by regulating a single kinetic parameter. In particular, the simplest three-state regulatory cycle can generate signals with two well-defined phases, each with distinct coding capabilities in terms of the information they can carry about the stimulus. We also demonstrate that such a kinase cycle can function as a signal categorizer classifying diverse incoming signals into outputs with a limited set of temporal activity profiles. Finally, we discuss the extension of the results to other regulatory motifs that could be understood in terms of the regimes of the three-state cycle. PMID:23823243

  7. Organic traffic control

    OpenAIRE

    Prothmann, Holger

    2011-01-01

    Modern cities cannot be imagined without traffic lights controlling the road network. To handle the network's changing demands efficiently, the signal plan specification needs to be shifted from the design time to the run-time of a signal system. The generic observer/controller architecture proposed for Organic Computing facilitates this shift. A two-levelled learning mechanism optimises signal plans on-line while a distributed coordination mechanism establishes green waves in the road network.

  8. 动态交通分配与信号控制的组合模型及算法研究%Research on Combined Dynamic Traffic Assignment and Signal Control

    Institute of Scientific and Technical Information of China (English)

    连爱萍; 高自友

    2005-01-01

    This paper presents a generalized bi-level programming model of combined dynamic traffic assignment and traffic signal control, and especially analyzes a procedure for determining the equilibrium queuing delays on saturated links for dynamic network signal control satisfying the FIFO (first-in-first-out) rule. The chaotic optimal algorithm proposed in this paper can not only present the optimal signal settings, but also calculate, at each interval, the link inflow rates and outflow rates for the dynamic user optimal problem, and provide real-time information for the travelers. Finally, a numerical example is given to illustrate the application of the proposed model and solution algorithm,and comparison shows that this model has better system performance.

  9. Modelling of diurnal cycle under climate change

    Energy Technology Data Exchange (ETDEWEB)

    Eliseev, A.V.; Bezmenov, K.V.; Demchenko, P.F.; Mokhov, I.I.; Petoukhov, V.K. [Russian Academy of Sciences, Moscow (Russian Federation). Inst. of Atmospheric Physics

    1995-12-31

    The observed diurnal temperature range (DTR) displays remarkable change during last 30 years. Land air DTR generally decreases under global climate warming due to more significant night minimum temperature increase in comparison with day maximum temperature increase. Atmosphere hydrological cycle characteristics change under global warming and possible background aerosol atmosphere content change may cause essential errors in the estimation of DTR tendencies of change under global warming. The result of this study is the investigation of cloudiness effect on the DTR and blackbody radiative emissivity diurnal range. It is shown that in some cases (particularly in cold seasons) it results in opposite change in DTR and BD at doubled CO{sub 2} atmosphere content. The influence of background aerosol is the same as the cloudiness one

  10. Generating clock signals for a cycle accurate, cycle reproducible FPGA based hardware accelerator

    Science.gov (United States)

    Asaad, Sameth W.; Kapur, Mohit

    2016-01-05

    A method, system and computer program product are disclosed for generating clock signals for a cycle accurate FPGA based hardware accelerator used to simulate operations of a device-under-test (DUT). In one embodiment, the DUT includes multiple device clocks generating multiple device clock signals at multiple frequencies and at a defined frequency ratio; and the FPG hardware accelerator includes multiple accelerator clocks generating multiple accelerator clock signals to operate the FPGA hardware accelerator to simulate the operations of the DUT. In one embodiment, operations of the DUT are mapped to the FPGA hardware accelerator, and the accelerator clock signals are generated at multiple frequencies and at the defined frequency ratio of the frequencies of the multiple device clocks, to maintain cycle accuracy between the DUT and the FPGA hardware accelerator. In an embodiment, the FPGA hardware accelerator may be used to control the frequencies of the multiple device clocks.

  11. Global Changes of the Water Cycle Intensity

    Science.gov (United States)

    Bosilovich, Michael G.; Schubert, Siegfried D.; Walker, Gregory K.

    2003-01-01

    In this study, we evaluate numerical simulations of the twentieth century climate, focusing on the changes in the intensity of the global water cycle. A new diagnostic of atmospheric water vapor cycling rate is developed and employed, that relies on constituent tracers predicted at the model time step. This diagnostic is compared to a simplified traditional calculation of cycling rate, based on monthly averages of precipitation and total water content. The mean sensitivity of both diagnostics to variations in climate forcing is comparable. However, the new diagnostic produces systematically larger values and more variability than the traditional average approach. Climate simulations were performed using SSTs of the early (1902-1921) and late (1979- 1998) twentieth century along with the appropriate C02 forcing. In general, the increase of global precipitation with the increases in SST that occurred between the early and late twentieth century is small. However, an increase of atmospheric temperature leads to a systematic increase in total precipitable water. As a result, the residence time of water in the atmosphere increased, indicating a reduction of the global cycling rate. This result was explored further using a number of 50-year climate simulations from different models forced with observed SST. The anomalies and trends in the cycling rate and hydrologic variables of different GCMs are remarkably similar. The global annual anomalies of precipitation show a significant upward trend related to the upward trend of surface temperature, during the latter half of the twentieth century. While this implies an increase in the hydrologic cycle intensity, a concomitant increase of total precipitable water again leads to a decrease in the calculated global cycling rate. An analysis of the land/sea differences shows that the simulated precipitation over land has a decreasing trend while the oceanic precipitation has an upward trend consistent with previous studies and the

  12. Changes in northeast African hydrology and vegetation associated with Pliocene-Pleistocene sapropel cycles.

    Science.gov (United States)

    Rose, Cassaundra; Polissar, Pratigya J; Tierney, Jessica E; Filley, Timothy; deMenocal, Peter B

    2016-07-01

    East African climate change since the Late Miocene consisted of persistent shorter-term, orbital-scale wet-dry cycles superimposed upon a long-term trend towards more open, grassy landscapes. Either or both of these modes of palaeoclimate variability may have influenced East African mammalian evolution, yet the interrelationship between these secular and orbital palaeoclimate signals remains poorly understood. Here, we explore whether the long-term secular climate change was also accompanied by significant changes at the orbital-scale. We develop northeast African hydroclimate and vegetation proxy data for two 100 kyr-duration windows near 3.05 and 1.75 Ma at ODP Site 967 in the eastern Mediterranean basin, where sedimentation is dominated by eastern Sahara dust input and Nile River run-off. These two windows were selected because they have comparable orbital configurations and bracket an important increase in East African C4 grasslands. We conducted high-resolution (2.5 kyr sampling) multiproxy biomarker, H- and C-isotopic analyses of plant waxes and lignin phenols to document orbital-scale changes in hydrology, vegetation and woody cover for these two intervals. Both intervals are dominated by large-amplitude, precession-scale (approx. 20 kyr) changes in northeast African vegetation and rainfall/run-off. The δ(13)Cwax values and lignin phenol composition record a variable but consistently C4 grass-dominated ecosystem for both intervals (50-80% C4). Precessional δDwax cycles were approximately 20-30‰ in peak-to-peak amplitude, comparable with other δDwax records of the Early Holocene African Humid Period. There were no significant differences in the means or variances of the δDwax or δ(13)Cwax data for the 3.05 and 1.75 Ma intervals studied, suggesting that the palaeohydrology and palaeovegetation responses to precessional forcing were similar for these two periods. Data for these two windows suggest that the eastern Sahara did not experience the

  13. Changing transport and traffic risks - a CliPDaR spin off

    Science.gov (United States)

    Matulla, Christoph; Namyslo, Joachim; Gringinger, Julia; Andre, Konrad; Chimani, Barbara; Hollosi, Brigitta; Mlinar, Christian; Gschier, Roland; Fuchs, Tobias; Auer, Inge

    2014-05-01

    The delivery of goods, people's mobility, the supply with services and the free accessibility of vital resources, as hospitals for instance, are indispensable for our society. All that is possible through functioning transport networks. Globalisation, changes in technology, demography and climate as well as the strong increase in freight traffic are fundamental challenges to the reinforcement of systems in place and the planning of future transport corridors. As for climate change we present an approach to estimate the rate and amount of change than has to be managed in the future by the transport authorities. This assessment is based on combinations of weather elements that potentially harm the transport system. Such combinations (called climate indices, CIs) are evaluated for the past and the future. The evaluation of the past is done by the use of observations; the assessment of the future is based on ensembles of scenario projections, since a single projection does not allow deriving uncertainty based statements. Landslides originating from long term rain events may serve as an example. In 2013 a number of landslides caused substantial destruction and downtimes in turn. The perhaps most prominent example took place in Tirol where the Felbertauern road was hit twice by landslides and the avalanche gallery was destroyed. In our presentation at the EGU we will show changes in CIs that are related to landslides, rutting, frost thaw cycles (e.g. responsible for falling roks) and heavy precipitation events (potentially important for the flooding of transport assets as tunnels and drainage systems or dangerous to bridges). These changes refer to two future periods: the near future (2021-2050) and the remote future (2071-2100); and they refer to the climatological normal period (19961-1990). Referring to landslides there are regions showing no change and other areas with substantial increases, which predominantly occur close to topographic complex terrain. Such regions

  14. Ventricular Cycle Length Characteristics Estimative of Prolonged RR Interval during Atrial Fibrillation

    Science.gov (United States)

    CIACCIO, EDWARD J.; BIVIANO, ANGELO B.; GAMBHIR, ALOK; EINSTEIN, ANDREW J.; GARAN, HASAN

    2014-01-01

    Background When atrial fibrillation (AF) is incessant, imaging during a prolonged ventricular RR interval may improve image quality. It was hypothesized that long RR intervals could be predicted from preceding RR values. Methods From the PhysioNet database, electrocardiogram RR intervals were obtained from 74 persistent AF patients. An RR interval lengthened by at least 250 ms beyond the immediately preceding RR interval (termed T0 and T1, respectively) was considered prolonged. A two-parameter scatterplot was used to predict the occurrence of a prolonged interval T0. The scatterplot parameters were: (1) RR variability (RRv) estimated as the average second derivative from 10 previous pairs of RR differences, T13–T2, and (2) Tm–T1, the difference between Tm, the mean from T13 to T2, and T1. For each patient, scatterplots were constructed using preliminary data from the first hour. The ranges of parameters 1 and 2 were adjusted to maximize the proportion of prolonged RR intervals within range. These constraints were used for prediction of prolonged RR in test data collected during the second hour. Results The mean prolonged event was 1.0 seconds in duration. Actual prolonged events were identified with a mean positive predictive value (PPV) of 80% in the test set. PPV was >80% in 36 of 74 patients. An average of 10.8 prolonged RR intervals per 60 minutes was correctly identified. Conclusions A method was developed to predict prolonged RR intervals using two parameters and prior statistical sampling for each patient. This or similar methodology may help improve cardiac imaging in many longstanding persistent AF patients. PMID:23998759

  15. GREEN ECONOMY AND CLIMATE CHANGE PREVENTION CYCLE

    Directory of Open Access Journals (Sweden)

    Andreea CONSTANTINESCU

    2014-12-01

    Full Text Available While experts in economics place transition to green economy on two directions - reducing ecological footprint and increasing human welfare - climate change specialists warn that effects of global warming will have a much greater impact in the future. It is natural to join scientific contributions in these two areas because both perspectives recognize the ravages made by industrialization, which triggered a serie of abrupt climate changes. For example, the average temperature in Europe has increased about 1oC. Based on these evidences, this article will show the usefulness of introducing a concept of full cycle to prevent climate change in the new paradigm that seeks to solve problems related to the fundamentals of sustainable development through transition to green economy. Using this method, this approach intends to be a new theoretical contribution which can act as support to efficiency of new clean technologies.

  16. Within-Subject Testing of the Signaled-Reinforcement Effect on Operant Responding as Measured by Response Rate and Resistance to Change

    Science.gov (United States)

    Reed, Phil; Doughty, Adam H.

    2005-01-01

    Response rates under random-interval schedules are lower when a brief (500 ms) signal accompanies reinforcement than when there is no signal. The present study examined this signaled-reinforcement effect and its relation to resistance to change. In Experiment 1, rats responded on a multiple random-interval 60-s random-interval 60-s schedule, with…

  17. Changes in Team Cognition after a Retention Interval: The Benefits of Mixing It up

    Science.gov (United States)

    Gorman, Jamie C.; Cooke, Nancy J.

    2011-01-01

    This paper examines the retention of team cognition with changes in team membership. Hypotheses are developed from shared cognition and interactive team cognition theories. We report a study of the effects of Short (3-6 weeks) versus Long (10-13 weeks) retention intervals and change (Mixed) versus no change (Intact) in team membership during the…

  18. Game Theory Model of Traffic Participants within Amber Time at Signalized Intersection

    Directory of Open Access Journals (Sweden)

    Weiwei Qi

    2014-01-01

    Full Text Available The traffic light scheme is composed of red, green, and amber lights, and it has been defined clearly for the traffic access of red and green lights; however, the definition of that for the amber light is indistinct, which leads to the appearance of uncertainty factors and serious traffic conflicts during the amber light. At present, the traffic administrations are faced with the decision of whether to forbid passing or not during the amber light in the cities of China. On one hand, it will go against the purpose of setting amber lights if forbidding passing; on the other hand, it may lead to a mess of traffic flow running if not. And meanwhile the drivers are faced with the decision of passing the intersection or stopping during the amber light as well. So the decision-making behavior of traffic administrations and drivers can be converted into a double game model. And through quantification of their earnings in different choice conditions, the optimum decision-making plan under specific conditions could be solved via the Nash equilibrium solution concept. Thus the results will provide a basis for the formulation of the traffic management strategy.

  19. Game theory model of traffic participants within amber time at signalized intersection.

    Science.gov (United States)

    Qi, Weiwei; Wen, Huiying; Fu, Chuanyun; Song, Mo

    2014-01-01

    The traffic light scheme is composed of red, green, and amber lights, and it has been defined clearly for the traffic access of red and green lights; however, the definition of that for the amber light is indistinct, which leads to the appearance of uncertainty factors and serious traffic conflicts during the amber light. At present, the traffic administrations are faced with the decision of whether to forbid passing or not during the amber light in the cities of China. On one hand, it will go against the purpose of setting amber lights if forbidding passing; on the other hand, it may lead to a mess of traffic flow running if not. And meanwhile the drivers are faced with the decision of passing the intersection or stopping during the amber light as well. So the decision-making behavior of traffic administrations and drivers can be converted into a double game model. And through quantification of their earnings in different choice conditions, the optimum decision-making plan under specific conditions could be solved via the Nash equilibrium solution concept. Thus the results will provide a basis for the formulation of the traffic management strategy. PMID:25580108

  20. Delay Estimates of Mixed Traffic Flow at Signalized Intersections in China

    Institute of Scientific and Technical Information of China (English)

    SU Yuelong; WEI Zheng; CHENG Sihan; YAO Danya; ZHANG Yi; LI Li

    2009-01-01

    Two characteristics of Chinese mixed traffic invalidate the conventional queuing delay estimates for western countries. First, the driving characteristics of Chinese drivers lead to different delays even though the other conditions are the same. Second, urban traffic flow in China is often hindered by pedestrians at intersections, such that imported intelligent traffic control systems do not work appropriately. Typical delay estimates for Chinese conditions were obtained from data for over 500 vehicle queues in Beijing collected using charge coupled device (CCD) cameras. The results show that the delays mainly depend on the pro-portion and positions of heavy vehicles in the queue, as well as the start-up situations (with or without inter-ference). A simplified delay estimation model considers vehicle types and positions that compares well with the observed traffic delays.

  1. Self-organized control of traffic signals based on reinforcement learning and genetic algorithm%基于再励学习和遗传算法的交通信号自组织控制

    Institute of Scientific and Technical Information of China (English)

    欧海涛; 杨煜普; 张文渊; 许晓鸣

    2000-01-01

    提出一种将再励学习与遗传算法相结合的遗传再励学习方法对交通信号进行自组织控制再励学习是针对每一个道路交叉口交通流的优化,修正每个信号灯周期的绿性比;而遗传算法产生局部学习过程的全局优化标准,即是修正信号灯周期的大小这种方法克服了现有的控制方法需要大量数据传输通讯、准确的交通模型等缺陷,将局部优化和全局优化统一起来通过计算机仿真实验表明了方法的有效性%A combination algorithm of reinforcement learning and genetic algorithm is proposed in this paper to self-organized control of the traffic signals.Reinforcement learning focuses on the optimization of an intersection traffic flow which modified the split of traffic signal cycle,while the genetic algorithm are intended to introduce a global optimization criterion to each of the local learning processes which modified the cycle itself of traffic signals.This method overcome the drawbacks in existing control methods such as huge data transfer and communication,accurately traffic model and so on,and unified the local optimization and global optimization.Through the computer simulation,the effectiveness of method is demonstated.

  2. The Impact of Continuous and Interval Cycle Exercise on Affect and Enjoyment

    Science.gov (United States)

    Kilpatrick, Marcus W.; Greeley, Samuel J.; Collins, Larry H.

    2015-01-01

    Rates of physical activity remain low despite public health efforts. One form of physical activity that provides significant physiological benefit but has not been evaluated in terms of affective and enjoyment responses is interval exercise. Purpose: The purpose of this study was to compare affect and enjoyment assessed before, during, and after…

  3. Reduction of the air traffic's contribution to climate change: A REACT4C case study

    Science.gov (United States)

    Grewe, Volker; Champougny, Thierry; Matthes, Sigrun; Frömming, Christine; Brinkop, Sabine; Søvde, Ole Amund; Irvine, Emma A.; Halscheidt, Lucia

    2014-09-01

    Air traffic alters the atmospheric composition and thereby contributes to climate change. Here we investigate the trans-Atlantic air traffic for one specific winter day and analyse, which routing changes were required to achieve a reduction in the air traffic's contribution to climate change. We have applied an atmosphere-chemistry model to calculate so-called five dimensional climate cost functions (CCF), which describe the climate effect of a locally confined emission. The five dimensions result from the emission location (3D), time (1D) and the type of emission (1D; carbon dioxide, water vapour, nitrogen oxides). In other words, carbon dioxide (CO2), water vapour (H2O) and nitrogen oxides (NOx) are emitted in amounts typical for aviation at many confined locations and times and their impacts on climate calculated with the atmosphere-chemistry model. The impact on climate results from direct effects, such as the changes in the concentration of the greenhouse gases CO2 and H2O and indirect effects such as contrail cirrus formation and chemical changes of ozone and methane by emissions of NOx. These climate cost functions are used by a flight planning tool to optimise flight routes with respect to their climate impact and economic costs of these routes. The results for this specific winter day show that large reductions in the air traffic's contribution to climate warming (up to 60%) can be achieved for westbound flights and smaller reductions for eastbound flights (around 25%). Eastbound flights take advantage of the tail winds from the jet stream and hence routings with lower climate impacts have a large fuel penalty, whenever they leave the jet stream. Maximum reduction in climate impact increases the economic costs by 10-15%, due to higher fuel consumption, caused by a longer flight distance and lower flight levels. However, with only small changes to the air traffic routings and flight altitudes, climate reductions up to 25% can be achieved by only small

  4. Muscle coordination changes during intermittent cycling sprints.

    Science.gov (United States)

    Billaut, François; Basset, Fabien A; Falgairette, Guy

    2005-06-01

    Maximal muscle power is reported to decrease during explosive cyclical exercises owing to metabolic disturbances, muscle damage, and adjustments in the efferent neural command. The aim of the present study was to analyze the influence of inter-muscle coordination in fatigue occurrence during 10 intermittent 6-s cycling sprints, with 30-s recovery through electromyographic activity (EMG). Results showed a decrease in peak power output with sprint repetitions (sprint 1 versus sprint 10: -11%, Pversus sprint 10: -90.2 ms, Pcycling sprints of short duration, decreased possibly due to the inability of muscles to maintain maximal force. This reduction in maximal power output occurred in parallel to changes in the muscle coordination pattern after fatigue. PMID:15862899

  5. Double cloprostenol administration during mid luteal phase of oestrous cycle does not modify the interoestrous interval in gilts

    Directory of Open Access Journals (Sweden)

    Claudio Mazzoni

    2014-07-01

    Full Text Available The present study was undertaken to test the effect of two vulva injections of D-cloprostenol on day 7, 9 and 10 of oestrous cycle on the duration of the interestrous interval in gilts. Following a pre-treatment oestrous cycle, 87 gilts were assigned to receive vulva injections of 75 μg D-cloprostenol at 08:00 and 14:00 h on day 7 (D7; n=30, day 9 (D9; n=29 or day 10 (D10; n=28 of their second observed oestrous cycle. Across the treatments, the duration of the oestrous cycle with D-cloprostenol treatment (19.1±0.1 d was not different from that of the previous oestrous cycle (20.1±0.4 days. Plasma progesterone concentrations were evaluated 6 h before and 24 and 72 h after D-cloprostenol treatment in the D9 group. Compared to pretreatment levels (9.6±0.4 ng/mL, plasma progesterone concentrations were reduced (P<0.05 at 24 h (6.3±1.0 ng/mL and 72 h after treatment but complete luteolysis did not occur. These data indicate that in gilts double vulva administration of D-cloprostenol is not able to induce a complete luteolisys and hence the duration of the oestrous cycle is not modified.

  6. TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Li [College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi 712100 (China); College of Life Sciences, Hainan Normal University, Haikou, Hainan 571158 (China); Huang, Yong; Du, Qian; Dong, Feng; Zhao, Xiaomin; Zhang, Wenlong; Xu, Xingang [College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi 712100 (China); Tong, Dewen, E-mail: dwtong@nwsuaf.edu.cn [College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi 712100 (China)

    2014-03-07

    Highlights: • TGEV N protein reduces cell viability by inducing cell cycle arrest and apoptosis. • TGEV N protein induces cell cycle arrest and apoptosis by regulating p53 signaling. • TGEV N protein plays important roles in TGEV-induced cell cycle arrest and apoptosis. - Abstract: Our previous studies showed that TGEV infection could induce cell cycle arrest and apoptosis via activation of p53 signaling in cultured host cells. However, it is unclear which viral gene causes these effects. In this study, we investigated the effects of TGEV nucleocapsid (N) protein on PK-15 cells. We found that TGEV N protein suppressed cell proliferation by causing cell cycle arrest at the S and G2/M phases and apoptosis. Characterization of various cellular proteins that are involved in regulating cell cycle progression demonstrated that the expression of N gene resulted in an accumulation of p53 and p21, which suppressed cyclin B1, cdc2 and cdk2 expression. Moreover, the expression of TGEV N gene promoted translocation of Bax to mitochondria, which in turn caused the release of cytochrome c, followed by activation of caspase-3, resulting in cell apoptosis in the transfected PK-15 cells following cell cycle arrest. Further studies showed that p53 inhibitor attenuated TGEV N protein induced cell cycle arrest at S and G2/M phases and apoptosis through reversing the expression changes of cdc2, cdk2 and cyclin B1 and the translocation changes of Bax and cytochrome c induced by TGEV N protein. Taken together, these results demonstrated that TGEV N protein might play an important role in TGEV infection-induced p53 activation and cell cycle arrest at the S and G2/M phases and apoptosis occurrence.

  7. Traffic-Related Air Pollution and QT Interval: Modification by Diabetes, Obesity, and Oxidative Stress Gene Polymorphisms in the Normative Aging Study

    OpenAIRE

    Baja, Emmanuel S; Schwartz, Joel D; Wellenius, Gregory A.; Coull, Brent A.; Zanobetti, Antonella; Vokonas, Pantel S; Suh, Helen H.

    2010-01-01

    Background Acute exposure to ambient air pollution has been associated with acute changes in cardiac outcomes, often within hours of exposure. Objectives We examined the effects of air pollutants on heart-rate–corrected QT interval (QTc), an electrocardiographic marker of ventricular repolarization, and whether these associations were modified by participant characteristics and genetic polymorphisms related to oxidative stress. Methods We studied repeated measurements of QTc on 580 men from t...

  8. Traffic of single-headed motor proteins KIF1A: effects of lane changing

    CERN Document Server

    Chowdhury, Debashish

    2007-01-01

    Kinesins are biomolecular motors which move on cylindrical nano-tubes called microtubules. A normal microtubule consists of more than one protofilament on which the equispaced motor binding sites form a periodic array. The collective movement of the kinesins on a microtubule is, therefore, analogous to vehicular traffic on multi-lane highways where each protofilament is the analogue of a single lane. We extend a recent model of the traffic of single-headed kinesin KIF1A [{\\it Phys. Rev. E {\\bf 75}, 041905 (2007)}] by incorporating processes which correspond to shifting of the motor proteins from one protofilament to another. On the basis of analytical treatment of our model, we predict the effects of lane changing on the flux of the KIF1A motors. Our quantitative predictions can be tested, in principle, by carrying out {\\it in-vitro} experiments with fluorescently labelled KIF1A molecules.

  9. Chapter 10 the primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair

    DEFF Research Database (Denmark)

    Christensen, Søren T; Pedersen, Stine F; Satir, Peter;

    2008-01-01

    Cell cycle control and migration are critical processes during development and maintenance of tissue functions. Recently, primary cilia were shown to take part in coordination of the signaling pathways that control these cellular processes in human health and disease. In this review, we present...... with the extracellular matrix, coordinate Wnt signaling, and modulate cytoskeletal changes that impinge on both cell cycle control and cell migration....

  10. Changes in continental Europe water cycle in a changing climate

    Science.gov (United States)

    Rouholahnejad, Elham; Schirmer, Mario; Abbaspour, Karim

    2015-04-01

    Changes in atmospheric water vapor content provide strong evidence that the water cycle is already responding to a warming climate. According to IPCC's last report on Climate Change (AR5), the water cycle is expected to intensify in a warmer climate as the atmosphere can hold more water vapor. This changes the frequency of precipitation extremes, increases evaporation and dry periods, and effects the water redistribution in land. This process is represented by most global climate models (GCMs) by increased summer dryness and winter wetness over large areas of continental mid to high latitudes in the Northern Hemisphere, associated with a reduction in water availability at continental scale. Observing changes in precipitation and evaporation directly and at continental scale is difficult, because most of the exchange of fresh water between the atmosphere and the surface happens the oceans. Long term precipitation records are available only from over the land and there are no measurement of evaporation or redistribution of precipitation over the land area. On the other hand, understanding the extent of climate change effects on various components of the water cycle is of strategic importance for public, private sectors, and policy makers when it comes to fresh water management. In order to better understand the extent of climate change impacts on water resources of continental Europe, we developed a distributed hydrological model of Europe at high spatial and temporal resolution using the Soil and Water Assessment Tool (SWAT). The hydrological model was calibrated for 1970 to 2006 using daily observation of streamflow and nitrate loads from 360 gauging stations across Europe. A vegetation growth routine was added to the model to better simulate evapotranspiration. The model results were calibrated with available agricultural crop yield data from other sources. As of future climate scenarios, we used the ISI-MIP project results which provides bias-corrected climate

  11. Life cycle cost optimization of biofuel supply chains under uncertainties based on interval linear programming

    DEFF Research Database (Denmark)

    Ren, Jingzheng; Dong, Liang; Sun, Lu;

    2015-01-01

    The aim of this work was to develop a model for optimizing the life cycle cost of biofuel supply chain under uncertainties. Multiple agriculture zones, multiple transportation modes for the transport of grain and biofuel, multiple biofuel plants, and multiple market centers were considered...... model, and the results showed that the proposed model is feasible for designing biofuel supply chain under uncertainties...

  12. Functional Nanoscale Imaging of Synaptic Vesicle Cycling with Superfast Fixation.

    Science.gov (United States)

    Schikorski, Thomas

    2016-01-01

    Functional imaging is the measurement of structural changes during an ongoing physiological process over time. In many cases, functional imaging has been implemented by tracking a fluorescent signal in live imaging sessions. Electron microscopy, however, excludes live imaging which has hampered functional imaging approaches on the ultrastructural level. This barrier was broken with the introduction of superfast fixation. Superfast fixation is capable of stopping and fixing membrane traffic at sufficient speed to capture a physiological process at a distinct functional state. Applying superfast fixation at sequential time points allows tracking of membrane traffic in a step-by-step fashion.This technique has been applied to track labeled endocytic vesicles at central synapses as they pass through the synaptic vesicle cycle. At synapses, neurotransmitter is released from synaptic vesicles (SVs) via fast activity-dependent exocytosis. Exocytosis is coupled to fast endocytosis that retrieves SVs components from the plasma membrane shortly after release. Fluorescent FM dyes that bind to the outer leaflet of the plasma membrane enter the endocytic vesicle during membrane retrieval and remain trapped in endocytic vesicles have been widely used to study SV exo-endocytic cycling in live imaging sessions. FM dyes can also be photoconverted into an electron-dense diaminobenzidine polymer which allows the investigation of SV cycling in the electron microscope. The combination of FM labeling with superfast fixation made it possible to track the fine structure of endocytic vesicles at 1 s intervals. Because this combination is not specialized to SV cycling, many other cellular processes can be studied. Furthermore, the technique is easy to set up and cost effective.This chapter describes activity-dependent FM dye labeling of SVs in cultured hippocampal neurons, superfast microwave-assisted fixation, photoconversion of the fluorescent endocytic vesicles, and the analysis of

  13. A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling.

    Science.gov (United States)

    Bae, Yong Ho; Mui, Keeley L; Hsu, Bernadette Y; Liu, Shu-Lin; Cretu, Alexandra; Razinia, Ziba; Xu, Tina; Puré, Ellen; Assoian, Richard K

    2014-06-17

    Tissue and extracellular matrix (ECM) stiffness is transduced into intracellular stiffness, signaling, and changes in cellular behavior. Integrins and several of their associated focal adhesion proteins have been implicated in sensing ECM stiffness. We investigated how an initial sensing event is translated into intracellular stiffness and a biologically interpretable signal. We found that a pathway consisting of focal adhesion kinase (FAK), the adaptor protein p130Cas (Cas), and the guanosine triphosphatase Rac selectively transduced ECM stiffness into stable intracellular stiffness, increased the abundance of the cell cycle protein cyclin D1, and promoted S-phase entry. Rac-dependent intracellular stiffening involved its binding partner lamellipodin, a protein that transmits Rac signals to the cytoskeleton during cell migration. Our findings establish that mechanotransduction by a FAK-Cas-Rac-lamellipodin signaling module converts the external information encoded by ECM stiffness into stable intracellular stiffness and mechanosensitive cell cycling. Thus, lamellipodin is important not only in controlling cellular migration but also for regulating the cell cycle in response to mechanical signals.

  14. A Life-Cycle Cost Estimating Methodology for NASA-Developed Air Traffic Control Decision Support Tools

    Science.gov (United States)

    Wang, Jianzhong Jay; Datta, Koushik; Landis, Michael R. (Technical Monitor)

    2002-01-01

    This paper describes the development of a life-cycle cost (LCC) estimating methodology for air traffic control Decision Support Tools (DSTs) under development by the National Aeronautics and Space Administration (NASA), using a combination of parametric, analogy, and expert opinion methods. There is no one standard methodology and technique that is used by NASA or by the Federal Aviation Administration (FAA) for LCC estimation of prospective Decision Support Tools. Some of the frequently used methodologies include bottom-up, analogy, top-down, parametric, expert judgement, and Parkinson's Law. The developed LCC estimating methodology can be visualized as a three-dimensional matrix where the three axes represent coverage, estimation, and timing. This paper focuses on the three characteristics of this methodology that correspond to the three axes.

  15. Variable-ratio versus variable-interval schedules: response rate, resistance to change, and preference.

    Science.gov (United States)

    Nevin, J A; Randolph; Holland, S; McLean, A P

    2001-07-01

    Two experiments asked whether resistance to change depended on variable-ratio as opposed to variable-interval contingencies of reinforcement and the different response rates they establish. In Experiment 1, pigeons were trained on multiple random-ratio random-interval schedules with equated reinforcer rates. Baseline response rates were disrupted by intercomponent food, extinction, and prefeeding. Resistance to change relative to baseline was greater in the interval component, and the difference was correlated with the extent to which baseline response rates were higher in the ratio component. In Experiment 2, pigeons were trained on multiple variable-ratio variable-interval schedules in one half of each session and on concurrent chains in the other half in which the terminal links corresponded to the multiple-schedule components. The schedules were varied over six conditions, including two with equated reinforcer rates. In concurrent chains, preference strongly overmatched the ratio of obtained reinforcer rates. In multiple schedules, relative resistance to response-independent food during intercomponent intervals, extinction, and intercomponent food plus extinction depended on the ratio of obtained reinforcer rates but was less sensitive than was preference. When reinforcer rates were similar, both preference and relative resistance were greater for the variable-interval schedule, and the differences were correlated with the extent to which baseline response rates were higher on the variable-ratio schedule, confirming the results of Experiment 1. These results demonstrate that resistance to change and preference depend in part on response rate as well as obtained reinforcer rate, and challenge the independence of resistance to change and preference with respect to response rate proposed by behavioral momentum theory. PMID:11516115

  16. Traffic sounds and cycling safety : the use of electronic devices by cyclists and the quietness of hybrid and electric cars.

    NARCIS (Netherlands)

    Stelling-Konczak, A. Hagenzieker, M.P. & Wee, B. van

    2015-01-01

    The growing popularity of electric devices and the increasing number of hybrid and electric cars have recently raised concerns about the use of auditory signals by vulnerable road users. This paper consolidates current knowledge about the two trends in relation to cycling safety. Both a literature r

  17. Design and application of PLC in traffic signal lamp%PLC在交通信号灯中的设计与应用

    Institute of Scientific and Technical Information of China (English)

    雷文斌

    2013-01-01

    This paper uses S7-200PLC as basic design components for the traffic signal lamp from two aspects of software design and hardware design of PLC traffic signal lamp and complete timing design and timing control chart of PLC traffic signal lamp and the PLC programming and the timing control design of PLC traffic signal. Finally, the article uses the traffic control of intersection in order to illustrate the realization process of the PLC traffic signal lamp control system.%  文章采用S7-200PLC做为交通信号灯设计的基本元件,从PLC交通信号灯硬件设计和PLC交通信号灯软件设计两方面着手,实现了PLC交通信号灯的时序设计以及时序控制图、实现了PLC编程设计、实现了PLC交通信号等的时序控制设计。最后,利用交叉路口交通控制来说明控制系统的PLC交通信号灯的实现过程。

  18. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    OpenAIRE

    Arking, Dan E; Sara L. Pulit; Crotti, Lia; van der Harst, Pim; Munroe, Patricia B; Koopmann, Tamara T.; Sotoodehnia, Nona; Rossin, Elizabeth J.; Morley, Michael; Wang, Xinchen; Johnson, Andrew D.; Lundby, Alicia; Gudbjartsson, Daníel F.; Noseworthy, Peter A.; Eijgelsheim, Mark

    2014-01-01

    The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal Mendelian Long QT Syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals we identified 35 common variant QT interval loci, that collectively explain ∼8-10% of QT variation and highlight the imp...

  19. Significant variations in Weber fraction for changes in inter-onset interval of a click train over the range of intervals between 5 and 300 ms

    OpenAIRE

    Ungan, Pekcan; Yagcioglu, Suha

    2014-01-01

    ORIGINAL RESEARCH ARTICLE published: 12 December 2014 doi: 10.3389/fpsyg.2014.01453 Significant variations in Weber fraction for changes in inter-onset interval of a click train over the range of intervals between 5 and 300 ms Pekcan Ungan1,2* and Suha Yagcioglu3 1 Department of Biophysics, School of Medicine, Koç University, Istanbul, Turkey 2 Science Academy, Istanbul, Turkey 3 Department of Biophysics, Faculty of Medicine, Hacettepe University, Ankara, Turkey ...

  20. Spontaneous-braking and lane-changing effect on traffic congestion using cellular automata model applied to the two-lane traffic

    Directory of Open Access Journals (Sweden)

    Kohei Arai

    2012-08-01

    Full Text Available In the real traffic situations, vehicle would make a braking as the response to avoid collision with another vehicle or avoid some obstacle like potholes, snow, or pedestrian that crosses the road unexpectedly. However, in some cases the spontaneous-braking may occur even though there are no obstacles in front of the vehicle. In some country, the reckless driving behaviors such as sudden-stop by public-buses, motorcycle which changing lane too quickly, or tailgating make the probability of braking getting increase. The new aspect of this paper is the simulation of braking behavior of the driver and presents the new Cellular Automata model for describing this characteristic. Moreover, this paper also examines the impact of lane-changing maneuvers to reduce the number of traffic congestion that caused by spontaneous-braking behavior of the vehicles.

  1. Estimated Aerobic Capacity Changes in Adolescents with Obesity Following High Intensity Interval Exercise

    OpenAIRE

    Brooke E. Starkoff; Eneli, Ihuoma U.; Andrea E. Bonny; Robert P. Hoffman; Steven T. Devor

    2014-01-01

    Vigorous aerobic exercise may improve aerobic capacity (VO2max) and cardiometabolic profiles in adolescents with obesity, independent of changes to weight. Our aim was to assess changes in estimated VO2max in obese adolescents following a 6-week exercise program of varying intensities. Adolescents with obesity were recruited from an American mid-west children’s hospital and randomized into moderate exercise (MOD) or high intensity interval exercise (HIIE) groups for a 6-week exercise interven...

  2. Jamitons: Phantom Traffic Jams

    Science.gov (United States)

    Kowszun, Jorj

    2013-01-01

    Traffic on motorways can slow down for no apparent reason. Sudden changes in speed by one or two drivers can create a chain reaction that causes a traffic jam for the vehicles that are following. This kind of phantom traffic jam is called a "jamiton" and the article discusses some of the ways in which traffic engineers produce…

  3. SOLAR CYCLE 24: CURIOUS CHANGES IN THE RELATIVE NUMBERS OF SUNSPOT GROUP TYPES

    Energy Technology Data Exchange (ETDEWEB)

    Kilcik, A. [Faculty of Science, Department of Space Science and Technologies, Akdeniz University, 07058 Antalya (Turkey); Yurchyshyn, V. B. [Big Bear Solar Observatory, Big Bear City, CA 92314 (United States); Ozguc, A. [Kandilli Observatory and Earthquake Research Institute, Bogazici University, 34684 Istanbul (Turkey); Rozelot, J. P., E-mail: alikilcik@akdeniz.edu.tr [Nice University (OCA), Bvd. de l' Observatoire, CS 34229, F-06304 Nice Cedex 4 (France)

    2014-10-10

    Here, we analyze different sunspot group (SG) behaviors from the points of view of both the sunspot counts (SSCs) and the number of SGs, in four categories, for the time period of 1982 January-2014 May. These categories include data from simple (A and B), medium (C), large (D, E, and F), and decaying (H) SGs. We investigate temporal variations of all data sets used in this study and find the following results. (1) There is a very significant decrease in the large groups' SSCs and the number of SGs in solar cycle 24 (cycle 24) compared to cycles 21-23. (2) There is no strong variation in the decaying groups' data sets for the entire investigated time interval. (3) Medium group data show a gradual decrease for the last three cycles. (4) A significant decrease occurred in the small groups during solar cycle 23, while no strong changes show in the current cycle (cycle 24) compared to the previous ones. We confirm that the temporal behavior of all categories is quite different from cycle to cycle and it is especially flagrant in solar cycle 24. Thus, we argue that the reduced absolute number of the large SGs is largely, if not solely, responsible for the weak cycle 24. These results might be important for long-term space weather predictions to understand the rate of formation of different groups of sunspots during a solar cycle and the possible consequences for the long-term geomagnetic activity.

  4. The burden of road traffic accidents in a French Departement: the description of the injuries and recent changes.

    OpenAIRE

    Chiron Mireille; Amoros Emmanuelle; Ndiaye Amina; Gadegbeku Blandine; Lapostolle Annabelle; Spira Alfred; Laumon Bernard

    2009-01-01

    Background: A significant reduction in road traffic accidents has been observed since prevention measures were introduced by the French public authorities in 2002. The goals of this study are to describe the burden of road traffic accidents in a French Departement, and to identify changes if any between the periods 1997-2001 and 2002-2006 on the basis of the disability adjusted life years (DALY). Methods: Years of lost life (YLL) and years lived with disabilit...

  5. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    DEFF Research Database (Denmark)

    Arking, Dan E; Pulit, Sara L; Crotti, Lia;

    2014-01-01

    The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Usi...

  6. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

    Science.gov (United States)

    Arking, Dan E; Pulit, Sara L; Crotti, Lia; van der Harst, Pim; Munroe, Patricia B; Koopmann, Tamara T; Sotoodehnia, Nona; Rossin, Elizabeth J; Morley, Michael; Wang, Xinchen; Johnson, Andrew D; Lundby, Alicia; Gudbjartsson, Daníel F; Noseworthy, Peter A; Eijgelsheim, Mark; Bradford, Yuki; Tarasov, Kirill V; Dörr, Marcus; Müller-Nurasyid, Martina; Lahtinen, Annukka M; Nolte, Ilja M; Smith, Albert Vernon; Bis, Joshua C; Isaacs, Aaron; Newhouse, Stephen J; Evans, Daniel S; Post, Wendy S; Waggott, Daryl; Lyytikäinen, Leo-Pekka; Hicks, Andrew A; Eisele, Lewin; Ellinghaus, David; Hayward, Caroline; Navarro, Pau; Ulivi, Sheila; Tanaka, Toshiko; Tester, David J; Chatel, Stéphanie; Gustafsson, Stefan; Kumari, Meena; Morris, Richard W; Naluai, Åsa T; Padmanabhan, Sandosh; Kluttig, Alexander; Strohmer, Bernhard; Panayiotou, Andrie G; Torres, Maria; Knoflach, Michael; Hubacek, Jaroslav A; Slowikowski, Kamil; Raychaudhuri, Soumya; Kumar, Runjun D; Harris, Tamara B; Launer, Lenore J; Shuldiner, Alan R; Alonso, Alvaro; Bader, Joel S; Ehret, Georg; Huang, Hailiang; Kao, W H Linda; Strait, James B; Macfarlane, Peter W; Brown, Morris; Caulfield, Mark J; Samani, Nilesh J; Kronenberg, Florian; Willeit, Johann; Smith, J Gustav; Greiser, Karin H; Meyer Zu Schwabedissen, Henriette; Werdan, Karl; Carella, Massimo; Zelante, Leopoldo; Heckbert, Susan R; Psaty, Bruce M; Rotter, Jerome I; Kolcic, Ivana; Polašek, Ozren; Wright, Alan F; Griffin, Maura; Daly, Mark J; Arnar, David O; Hólm, Hilma; Thorsteinsdottir, Unnur; Denny, Joshua C; Roden, Dan M; Zuvich, Rebecca L; Emilsson, Valur; Plump, Andrew S; Larson, Martin G; O'Donnell, Christopher J; Yin, Xiaoyan; Bobbo, Marco; D'Adamo, Adamo P; Iorio, Annamaria; Sinagra, Gianfranco; Carracedo, Angel; Cummings, Steven R; Nalls, Michael A; Jula, Antti; Kontula, Kimmo K; Marjamaa, Annukka; Oikarinen, Lasse; Perola, Markus; Porthan, Kimmo; Erbel, Raimund; Hoffmann, Per; Jöckel, Karl-Heinz; Kälsch, Hagen; Nöthen, Markus M; den Hoed, Marcel; Loos, Ruth J F; Thelle, Dag S; Gieger, Christian; Meitinger, Thomas; Perz, Siegfried; Peters, Annette; Prucha, Hanna; Sinner, Moritz F; Waldenberger, Melanie; de Boer, Rudolf A; Franke, Lude; van der Vleuten, Pieter A; Beckmann, Britt Maria; Martens, Eimo; Bardai, Abdennasser; Hofman, Nynke; Wilde, Arthur A M; Behr, Elijah R; Dalageorgou, Chrysoula; Giudicessi, John R; Medeiros-Domingo, Argelia; Barc, Julien; Kyndt, Florence; Probst, Vincent; Ghidoni, Alice; Insolia, Roberto; Hamilton, Robert M; Scherer, Stephen W; Brandimarto, Jeffrey; Margulies, Kenneth; Moravec, Christine E; del Greco M, Fabiola; Fuchsberger, Christian; O'Connell, Jeffrey R; Lee, Wai K; Watt, Graham C M; Campbell, Harry; Wild, Sarah H; El Mokhtari, Nour E; Frey, Norbert; Asselbergs, Folkert W; Mateo Leach, Irene; Navis, Gerjan; van den Berg, Maarten P; van Veldhuisen, Dirk J; Kellis, Manolis; Krijthe, Bouwe P; Franco, Oscar H; Hofman, Albert; Kors, Jan A; Uitterlinden, André G; Witteman, Jacqueline C M; Kedenko, Lyudmyla; Lamina, Claudia; Oostra, Ben A; Abecasis, Gonçalo R; Lakatta, Edward G; Mulas, Antonella; Orrú, Marco; Schlessinger, David; Uda, Manuela; Markus, Marcello R P; Völker, Uwe; Snieder, Harold; Spector, Timothy D; Ärnlöv, Johan; Lind, Lars; Sundström, Johan; Syvänen, Ann-Christine; Kivimaki, Mika; Kähönen, Mika; Mononen, Nina; Raitakari, Olli T; Viikari, Jorma S; Adamkova, Vera; Kiechl, Stefan; Brion, Maria; Nicolaides, Andrew N; Paulweber, Bernhard; Haerting, Johannes; Dominiczak, Anna F; Nyberg, Fredrik; Whincup, Peter H; Hingorani, Aroon D; Schott, Jean-Jacques; Bezzina, Connie R; Ingelsson, Erik; Ferrucci, Luigi; Gasparini, Paolo; Wilson, James F; Rudan, Igor; Franke, Andre; Mühleisen, Thomas W; Pramstaller, Peter P; Lehtimäki, Terho J; Paterson, Andrew D; Parsa, Afshin; Liu, Yongmei; van Duijn, Cornelia M; Siscovick, David S; Gudnason, Vilmundur; Jamshidi, Yalda; Salomaa, Veikko; Felix, Stephan B; Sanna, Serena; Ritchie, Marylyn D; Stricker, Bruno H; Stefansson, Kari; Boyer, Laurie A; Cappola, Thomas P; Olsen, Jesper V; Lage, Kasper; Schwartz, Peter J; Kääb, Stefan; Chakravarti, Aravinda; Ackerman, Michael J; Pfeufer, Arne; de Bakker, Paul I W; Newton-Cheh, Christopher

    2014-08-01

    The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD. PMID:24952745

  7. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    NARCIS (Netherlands)

    D.E. Arking (Dan); S.L. Pulit (Sara); L. Crotti (Lia); P. van der Harst (Pim); P. Munroe (Patricia); T.T. Koopmann (Tamara); N. Sotoodehnia (Nona); E. Rossin (Elizabeth); M. Morley (Michael); X. Wang (Xinchen); A.D. Johnson (Andrew); A. Lundby (Alicia); D.F. Gudbjartsson (Daniel); P.A. Noseworthy (Peter); M. Eijgelsheim (Mark); Y. Bradford (Yuki); K.V. Tarasov (Kirill); M. Dörr (Marcus); M. Müller-Nurasyid (Martina); A.M. Lahtinen (Annukka); I.M. Nolte (Ilja); G.D. Smith; J.C. Bis (Joshua); A.J. Isaacs (Aaron); S.J. Newhouse (Stephen); D.S. Evans (Daniel); W.S. Post (Wendy S.); D. Waggott (Daryl); L.-P. Lyytikäinen (Leo-Pekka); A.A. Hicks (Andrew); L. Eisele (Lewin); D. Ellinghaus (David); C. Hayward (Caroline); P. Navarro (Pau); S. Ulivi (Shelia); T. Tanaka (Toshiko); D.J. Tester (David); S. Chatel (Stéphanie); S. Gustafsson (Stefan); M. Kumari (Meena); R. Morris (Richard); A.T. Naluai (Asa); S. Padmanabhan (Sandosh); A. Kluttig (Alexander); B. Strohmer (Bernhard); A.G. Panayiotou (Andrie); M. Torres (Maria); M. Knoflach (Michael); J.A. Hubacek (Jaroslav A.); K. Slowikowski (Kamil); S. Raychaudhuri (Soumya); R.D. Kumar (Runjun); T.B. Harris (Tamara); L.J. Launer (Lenore); A.R. Shuldiner (Alan); A. Alonso (Alvaro); J.S. Bader (Joel); G.B. Ehret (Georg); H. Huang (Hailiang); W.H.L. Kao (Wen); J.B. Strait (James); P.W. Macfarlane (Peter); M.J. Brown (Morris); M. Caulfield (Mark); N.J. Samani (Nilesh); F. Kronenberg (Florian); J. Willeit (Johann); J.G. Smith (J. Gustav); K.H. Greiser (Karin Halina); H.M. Zu Schwabedissen (Henriette Meyer); K. Werdan (Karl); C. Carella (Cintia); L. Zelante (Leopoldo); S.R. Heckbert (Susan); B.M. Psaty (Bruce); J.I. Rotter (Jerome); I. Kolcic (Ivana); O. Polasek (Ozren); A.F. Wright (Alan); M. Griffin (Maura); M.J. Daly (Mark); D.O. Arnar (David); H. Hólm (Hilma); U. Thorsteinsdottir (Unnur); J.C. Denny (Joshua); D.M. Roden (Dan); R.L. Zuvich (Rebecca); V. Emilsson (Valur); A.S. Plump (Andrew); M.G. Larson (Martin); C.J. O'Donnell (Christopher); X. Yin (Xiaoyan); M. Bobbo (Marco); P. D'Adamo (Pio); A. Iorio (Annamaria); G. Sinagra (Gianfranco); A. Carracedo (Angel); S.R. Cummings (Steven); M.A. Nalls (Michael); A. Jula (Antti); K.K. Kontula (Kimmo); A. Marjamaa (Annukka); L. Oikarinen (Lasse); M. Perola (Markus); K. Porthan (Kimmo); R. Erbel (Raimund); P. Hoffmann (Per); K.-H. Jöckel (Karl-Heinz); H. Kälsch (Hagen); M.M. Nöthen (Markus); M. den Hoed (Marcel); R.J.F. Loos (Ruth); D.S. Thelle (Dag); C. Gieger (Christian); T. Meitinger (Thomas); S. Perz (Siegfried); A. Peters (Annette); H. Prucha (Hanna); M.F. Sinner (Moritz); M. Waldenberger (Melanie); R.A. de Boer (Rudolf); L. Franke (Lude); P.A. van der Vleuten (Pieter); B.M. Beckmann (Britt); E. Martens (Eimo); A. Bardai (Abdennasser); N. Hofman (Nynke); A.A.M. Wilde (Arthur); E.R. Behr (Elijah ); C. Dalageorgou (Chrysoula); J.R. Giudicessi (John); A. Medeiros-Domingo (Argelia); J. Barc (Julien); F. Kyndt (Florence); V. Probst (Vincent); A. Ghidoni (Alice); R. Insolia (Roberto); R.M. Hamilton (Robert); S.W. Scherer (Stephen); J. Brandimarto (Jeffrey); K. Margulies (Kenneth); C.E. Moravec (Christine); F. Del Greco M (Fabiola); C. Fuchsberger (Christian); J.R. O'Connell (Jeffery); W.K. Lee (Wai); G.C.M. Watt (Graham); H. Campbell (Harry); S.H. Wild (Sarah); N.E. El Mokhtari (Nour); N. Frey (Norbert); F.W. Asselbergs (Folkert); I.M. Leach (Irene Mateo); G. Navis (Gerjan); M.P. van den Berg (Maarten); D.J. van Veldhuisen (Dirk); M. Kellis (Manolis); B.P. Krijthe (Bouwe); O.H. Franco (Oscar); A. Hofman (Albert); J.A. Kors (Jan); A.G. Uitterlinden (André); J.C.M. Witteman (Jacqueline); L. Kedenko (Lyudmyla); C. Lamina (Claudia); B.A. Oostra (Ben); G.R. Abecasis (Gonçalo); E. Lakatta (Edward); A. Mulas (Antonella); M. Orrù (Marco); D. Schlessinger (David); M. Uda (Manuela); M.R.P. Markus (Marcello R. P.); U. Völker (Uwe); H. Snieder (Harold); T.D. Spector (Timothy); J. Ärnlöv (Johan); L. Lind (Lars); J. Sundstrom (Johan); A.C. Syvanen; M. Kivimaki (Mika); M. Kähönen (Mika); K. Mononen (Kari); O. Raitakari (Olli); J. Viikari (Jorma); V. Adamkova (Vera); S. Kiechl (Stefan); M.-J. Brion (Maria); A.N. Nicolaides (Andrew); B. Paulweber (Bernhard); J. Haerting (Johannes); A. Dominiczak (Anna); F. Nyberg (Fredrik); P.H. Whincup (Peter); A. Hingorani (Aroon); J.-J. Schott (Jean-Jacques); C.R. Bezzina (Connie); E. Ingelsson (Erik); L. Ferrucci (Luigi); P. Gasparini (Paolo); J.F. Wilson (James); I. Rudan (Igor); A. Franke (Andre); T.W. Mühleisen (Thomas); P.P. Pramstaller (Peter Paul); T. Lehtimäki (Terho); A.D. Paterson (Andrew); A. Parsa (Afshin); Y. Liu (Yongmei); C.M. van Duijn (Cock); D.S. Siscovick (David); V. Gudnason (Vilmundur); Y. Jamshidi (Yalda); V. Salomaa (Veikko); S.B. Felix (Stephan); S. Sanna (Serena); M.D. Ritchie (Marylyn); B.H.Ch. Stricker (Bruno); J-A. Zwart (John-Anker); L.A. Boyer (Laurie); T.P. Cappola (Thomas); J.V. Olsen (Jesper); P. Lage (Pedro); P.J. Schwartz (Peter); S. Kääb (Stefan); A. Chakravarti (Aravinda); M. Ackerman (Margaret); A. Pfeufer (Arne); P.I.W. de Bakker (Paul); C. Newton-Cheh (Christopher)

    2014-01-01

    textabstractThe QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (L

  8. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    NARCIS (Netherlands)

    Arking, Dan E.; Pulit, Sara L.; Crotti, Lia; Van der Harst, Pim; Munroe, Patricia B.; Koopmann, Tamara T.; Sotoodehnia, Nona; Rossin, Elizabeth J.; Morley, Michael; Wang, Xinchen; Johnson, Andrew D.; Lundby, Alicia; Gudbjartsson, Daniel F.; Noseworthy, Peter A.; Eijgelsheim, Mark; Bradford, Yuki; Tarasov, Kirill V.; Dorr, Marcus; Miiller-Nurasyid, Martina; Lahtinen, Annukka M.; Nolte, Ilja M.; Smith, Albert Vernon; Bis, Joshua C.; Isaacs, Aaron; Newhouse, Stephen J.; Evans, Daniel S.; Post, Wendy S.; Waggott, Daryl; Lyytikainen, Leo-Pekka; Hicks, Andrew A.; Eisele, Lewin; Ellinghaus, David; Hayward, Caroline; Navarro, Pau; Ulivi, Sheila; Tanaka, Toshiko; Tester, David J.; Chatel, Stephanie; Gustafsson, Stefan; Kumari, Meena; Morris, Richard W.; Naluai, Asa T.; Padmanabhan, Sandosh; Kluttig, Alexander; Strohmer, Bernhard; Panayiotou, Andrie G.; Torres, Maria; Knoflach, Michael; Hubacek, Jaroslav A.; Slowikowski, Kamil; Raychaudhuri, Soumya; Kumar, Runjun D.; Harris, Tamara B.; Launer, Lenore J.; Shuldiner, Alan R.; Alonso, Alvaro; Bader, Joel S.; EhreT, Georg; Huang, Hailiang; Kao, W. H. Linda; Strait, James B.; Macfarlane, Peter W.; Brown, Morris; Caulfield, Mark J.; Samani, Nilesh J.; Kronenberg, Florian; Willeit, Johann; Smith, J. Gustav; Greiser, Karin H.; Schwabedissen, Henriette Meyer Zu; Werdan, Karl; Carella, Massimo; Zelante, Leopoldo; Heckbert, Susan R.; Psaty, Bruce M.; Rotter, Jerome I.; Kolcic, Ivana; Poagek, Ozren; Wright, Alan F.; Griffin, Maura; Daly, Mark J.; Arnar, David O.; Holm, Hilma; Thorsteinsdottir, Unnur; Denny, Joshua C.; Roden, Dan M.; Zuvich, Rebecca L.; Emilsson, Valur; Plump, Andrew S.; Larson, Martin G.; O'Donnell, Christopher J.; Yin, Xiaoyan; Bobboll, Marco; D'Adamo, Adamo P.; Iorio, Annamaria; Sinagra, Gianfranco; Carracedo, Angel; Cummings, Steven R.; Nalls, Michael A.; Jula, Antti; Kontula, Kimmo K.; Marjamaa, Annukka; Oikarinen, Lasse; Perola, Markus; Porthan, Kimmo; Erbe, Raimund; Hoffmann, Per; Jockel, Karl-Heinz; Kalsch, Hagen; Nothen, Markus M.; Den Hoed, Marcel; Loos, Ruth J. F.; Thelle, Dag S.; Gieger, Christian; Meitinger, Thomas; Perz, Siegfried; Peters, Annette; Pruchal, Hanna; Sinner, Moritz F.; Waldenberger, Melanie; De Boer, Rudolf A.; Franke, Lude; Van der Vleuten, Pieter A.; Beckmann, Britt Maria; Martens, Eimo; Bardail, Abdennasser; Hofman, Nynke; Wilde, Arthur A. M.; Behr, Elijah R.; Dalageorgou, Chrysoula; Giudicessi, John R.; Medeiros-Domingo, Argelia; Barc, Julien; Kyndt, Florence; Probst, Vincent; Ghidoni, Alice; Insolia, Roberto; Hamilton, Robert M.; Scherer, Stephen W.; Brandimarto, Jeffrey; Margulies, Kenneth; Moravec, Christine E.; Del Greco, Fabiola; Fuchsberger, Christian; O'Connell, Jeffrey R.; Lee, Wai K.; Watt, Graham C. M.; Campbell, Harry; Wild, Sarah H.; El Mokhtari, Nour E.; Frey, Norbert; Asselbergs, Folkert W.; Mateo Leach, Irene; Navis, Gerjan; Van den Berg, Maarten P.; Van Veldhuisen, Dirk J.; Kellis, Manolis; Krijthe, Bouwe P.; Franco, Oscar H.; Hofman, Albert; Kors, Jan A.; Uitterlinden, Andre G.; Witteman, Jacqueline C. M.; Kedenko, Lyudmyla; Lamina, Claudia; Oostra, Ben A.; Abecasis, Goncalo R.; Lakatta, Edward G.; Mulas, Antonella; Orru, Marco; Schlessinger, David; Uda, Manuela; Markus, Marcello R. P.; Volker, Uwe; Snieder, Harold; Spector, Timothy D.; Arnlov, Johan; Lind, Lars; Sundstrom, Johan; Syvanen, Ann-Christine; Kivimaki, Mika; Kahonen, Mika; Mononen, Nina; Raitakari, I. T.; Viikari, Jorma S.; Adamkova, Vera; Kiech, Stefan; Brion, Maria; Nicolaides, Andrew N.; Paulweber, Bernhard; Haerting, Johannes; Dominiczak, Anna F.; Nyberg, Fredrik; Whincup, Peter H.; Hingorani, Aroon D.; Schott, Jean-Jacques; Bezzina, Connie R.; Ingelsson, Erik; Ferrucci, Luigi; Gaspariniin, Paolo; Wilson, James F.; Rudan, Igor; Franke, Andre; Miihleisen, Thomas W.; Pramstaller, Peter P.; Lehtimaki, Terho J.; Paterson, Andrew D.; Parsa, Afshin; Liu, Yongmei; Van Duijn, Cornelia M.; Siscovick, David S.; Gudnason, Vilmundur; Jamshidi, Yalda; Salomaa, Veikko; Felix, Stephan B.; Sanna, Serena; Ritchie, Marylyn D.; Stricker, Bruno H.; Stefansson, Karl; Boyer, Laurie A.; Cappola, Thomas P.; Olsen, Jesper V.; Lage, Kasper; Schwartz, Peter J.; Kaab, Stefan; Chakravarti, Aravinda; Ackerman, Michael J.; Pfeufer, Arne; De Bakker, Paul I. W.; Newton-Cheh, Christopher

    2014-01-01

    The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using

  9. Delay Analysis and Formulation Inference of Signalized Intersection for Traffic Congestion Conditions

    Institute of Scientific and Technical Information of China (English)

    刘广萍; 丁建梅

    2004-01-01

    Vehicle delay is an important measure to evaluate the signal timings of signalized intersections.When optimization the signal control parameters, delays of vehicles from all approach directions of an intersection should be considered. Based on the analysis of the vehicle delay on an approach of intersection, directed against the typical condition of a congested intersection-over-saturated condition, the paper has analyzed and inferred the intersection delay dynamic formulation, and has established the relation between intersection delay,the signal timings, vehicle arrival rate and the queue lengths, and that provides useful information for understanding vehicle delay of signalized intersection and for establishing performance index function of signal timing optimization.

  10. Aerobic and anaerobic changes with high-intensity interval training in active college-aged men.

    Science.gov (United States)

    Ziemann, Ewa; Grzywacz, Tomasz; Łuszczyk, Marcin; Laskowski, Radoslaw; Olek, Robert A; Gibson, Ann L

    2011-04-01

    We investigated the aerobic and anaerobic benefits of high-intensity interval training performed at a work-to-rest ratio of 1:2 because little performance enhancement data exist based on this ratio. Recreationally active male volunteers (21 years, 184 cm, 81.5 kg) were randomly assigned to a training (interval training [IT] n = 10) or control group (n = 11). Baseline assessments were repeated after the last training session. Each participant underwent basic anthropometric assessment and performed a VO2max test on an electronically braked cycle ergometer and a 30-second Wingate test. Venous samples were acquired at the antecubital vein and subsequently processed for lactate (LA); samples were obtained at rest, and 5 and 15-minute post-Wingate test. The interval training used a cycling power output equivalent to 80% of VO2max (80% p VO2max) applied for 6 90-second bouts (each followed by 180-second rest) per session, 3 sessions per week, for 6 weeks. The control group maintained their normal routine for the 6-week period. Group × time repeated-measures analyses of variance revealed that IT improved VO2max (5.5 ml · kg(-1) · min), anaerobic threshold (3.8 ml · kg(-1) · min), work output (12.5 J · kg(-1)), glycolytic work (11.5 J · kg(-1)), mean power (0.3 W · kg), peak power (0.4 W · kg(-1)), and max power (0.4 W · kg(-1)); p training program may rapidly restore or improve a client's or athlete's maximal functional capacity.

  11. Long-term exposure to residential traffic noise and changes in body weight and waist circumference

    DEFF Research Database (Denmark)

    Christensen, Jeppe S.; Raaschou-Nielsen, Ole; Tjønneland, Anne;

    2015-01-01

    for age, sex, socioeconomic position and lifestyle factors in three models with increasing adjustment. RESULTS: In linear models adjusted for sex, age, socioeconomic position and competing noise sources we found road traffic noise to be significantly associated with small gains in both weight and waist......: We aimed to investigate the association between long-term residential traffic noise and changes in adiposity. MATERIALS AND METHODS: The study was based on 39,720 middle-aged Danish men and women from a cohort, with information on weight and waist circumference at two points in time. Residential...... an 10% increased risk for gaining more than 5kg body weight during follow-up (95% CI: 1.04; 1.15) per 10dB higher 5 years exposure preceding follow-up. Exposure to railway noise above 55dB was associated with weight gain (39.9g/year (95% CI: 10.2; 69.6)), but not with a significant change in waist...

  12. Traffic sounds and cycling safety : the use of electronic devices by cyclists and the quietness of hybrid and electric cars.

    OpenAIRE

    Stelling-Konczak, A. Hagenzieker, M. & Wee, B. van

    2015-01-01

    The growing popularity of electric devices and the increasing number of hybrid and electric cars have recently raised concerns about the use of auditory signals by vulnerable road users. This paper consolidates current knowledge about the two trends in relation to cycling safety. Both a literature review and a crash data analysis were carried out. Based on a proposed conceptual model, knowledge gaps are identified that need to be addressed for a better understanding of the relation between li...

  13. Physiological and performance changes from the addition of a sprint interval program to wrestling training.

    Science.gov (United States)

    Farzad, Babak; Gharakhanlou, Reza; Agha-Alinejad, Hamid; Curby, David G; Bayati, Mahdi; Bahraminejad, Morteza; Mäestu, Jarek

    2011-09-01

    Increasing the level of physical fitness for competition is the primary goal of any conditioning program for wrestlers. Wrestlers often need to peak for competitions several times over an annual training cycle. Additionally, the scheduling of these competitions does not always match an ideal periodization plan and may require a modified training program to achieve a high level of competitive fitness in a short-time frame. The purpose of this study was to examine the effects of 4 weeks of sprint-interval training (SIT) program, on selected aerobic and anaerobic performance indices, and hormonal and hematological adaptations, when added to the traditional Iranian training of wrestlers in their preseason phase. Fifteen trained wrestlers were assigned to either an experimental (EXP) or a control (CON) group. Both groups followed a traditional preparation phase consisting of learning and drilling technique, live wrestling and weight training for 4 weeks. In addition, the EXP group performed a running-based SIT protocol. The SIT consisted of 6 35-m sprints at maximum effort with a 10-second recovery between each sprint. The SIT protocol was performed in 2 sessions per week, for the 4 weeks of the study. Before and after the 4-week training program, pre and posttesting was performed on each subject on the following: a graded exercise test (GXT) to determine VO(2)max, the velocity associated with V(2)max (νVO(2)max), maximal ventilation, and peak oxygen pulse; a time to exhaustion test (T(max)) at their νVO(2)max; and 4 successive Wingate tests with a 4-minute recovery between each trial for the determination of peak and mean power output (PPO, MPO). Resting blood samples were also collected at the beginning of each pre and posttesting period, before and after the 4-week training program. The EXP group showed significant improvements in VO(2)max (+5.4%), peak oxygen pulse (+7.7%) and T(max) (+32.2%) compared with pretesting. The EXP group produced significant increases

  14. Changes in mitochondrial function and mitochondria associated protein expression in response to 2-weeks of high intensity interval training

    Directory of Open Access Journals (Sweden)

    Grace eVincent

    2015-02-01

    Full Text Available Purpose: High-intensity short-duration interval training (HIT stimulates functional and metabolic adaptation in skeletal muscle, but the influence of HIT on mitochondrial function remains poorly studied in humans. Mitochondrial metabolism, as well as mitochondrial-associated protein expression were tested in untrained participants performing HIT over a two-week period. Methods: Eight males performed a single-leg cycling protocol (12 x 1 min intervals at 120% peak power output, 90 s recovery, 4 days/week. Muscle biopsies (vastus lateralis were taken pre- and post-HIT. Mitochondrial respiration in permeabilized fibres, citrate synthase (CS activity and protein expression of peroxisome proliferator-activated receptor gamma coactivator (PGC-1α and respiratory complex components were measured. Results: HIT training improved peak power and time to fatigue. Increases in absolute oxidative phosphorylation (OXPHOS capacities and CS activity were observed, but not in the ratio of CCO to the electron transport system (CCO/ETS, the respiratory control ratios (RCR-1 and RCR-2 or mitochondrial-associated protein expression. Specific increases in OXPHOS flux were not apparent after normalization to CS, indicating that gross changes mainly resulted from increased mitochondrial mass. Conclusion: Over only 2 weeks HIT significantly increased mitochondrial function in skeletal muscle independently of detectable changes in mitochondrial-associated and mitogenic protein expression.

  15. Impulsive sounds change European seabass swimming patterns: Influence of pulse repetition interval

    International Nuclear Information System (INIS)

    Highlights: • We exposed impulsive sounds of different repetition intervals to European seabass. • Immediate behavioural changes mirrored previous indoor & outdoor studies. • Repetition intervals influenced the impacts differentially but not the recovery. • Sound temporal patterns may be more important than some standard metrics. - Abstract: Seismic shootings and offshore pile-driving are regularly performed, emitting significant amounts of noise that may negatively affect fish behaviour. The pulse repetition interval (PRI) of these impulsive sounds may vary considerably and influence the behavioural impact and recovery. Here, we tested the effect of four PRIs (0.5–4.0 s) on European seabass swimming patterns in an outdoor basin. At the onset of the sound exposures, the fish swam faster and dived deeper in tighter shoals. PRI affected the immediate and delayed behavioural changes but not the recovery time. Our study highlights that (1) the behavioural changes of captive European seabass were consistent with previous indoor and outdoor studies; (2) PRI could influence behavioural impact differentially, which may have management implications; (3) some acoustic metrics, e.g. SELcum, may have limited predictive power to assess the strength of behavioural impacts of noise. Noise impact assessments need to consider the contribution of sound temporal structure

  16. Maintenance: Changing Role in Life Cycle Management

    NARCIS (Netherlands)

    Takata, S.; Kimura, F.; Houten, van F.J.A.M.; Westkamper, E.; Shpitalni, M.; Ceglarek, D.; Lee, J.

    2004-01-01

    As attention to environmental problems grows, product life cycle management is becoming a crucial issue in realizing a sustainable society. Our objective is to provide the functions necessary for such a society while minimizing material and energy consumption. From this viewpoint, we should redefine

  17. Green Wave Traffic Optimization - A Survey

    DEFF Research Database (Denmark)

    Warberg, Andreas; Larsen, Jesper; Jørgensen, Rene Munk

    The objective of this survey is to cover the research in the area of adaptive traffic control with emphasis on the applied optimization methods. The problem of optimizing traffic signals can be viewed in various ways, depending on political, economic and ecological goals. The survey highlights some...... important conflicts, which support the notion that traffic signal optimization is a multi-objective problem, and relates this to the most common measures of effectiveness. A distinction can be made between classical systems, which operate with a common cycle time, and the more flexible, phase......-based, approach, which is shown to be more suitable for adaptive traffic control. To support this claim three adaptive systems, which use alternatives to the classical optimization procedures, are described in detail....

  18. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    Science.gov (United States)

    Arking, Dan E.; Pulit, Sara L.; Crotti, Lia; van der Harst, Pim; Munroe, Patricia B.; Koopmann, Tamara T.; Sotoodehnia, Nona; Rossin, Elizabeth J.; Morley, Michael; Wang, Xinchen; Johnson, Andrew D.; Lundby, Alicia; Gudbjartsson, Daníel F.; Noseworthy, Peter A.; Eijgelsheim, Mark; Bradford, Yuki; Tarasov, Kirill V.; Dörr, Marcus; Müller-Nurasyid, Martina; Lahtinen, Annukka M.; Nolte, Ilja M.; Smith, Albert Vernon; Bis, Joshua C.; Isaacs, Aaron; Newhouse, Stephen J.; Evans, Daniel S.; Post, Wendy S.; Waggott, Daryl; Lyytikäinen, Leo-Pekka; Hicks, Andrew A.; Eisele, Lewin; Ellinghaus, David; Hayward, Caroline; Navarro, Pau; Ulivi, Sheila; Tanaka, Toshiko; Tester, David J.; Chatel, Stéphanie; Gustafsson, Stefan; Kumari, Meena; Morris, Richard W.; Naluai, Åsa T.; Padmanabhan, Sandosh; Kluttig, Alexander; Strohmer, Bernhard; Panayiotou, Andrie G.; Torres, Maria; Knoflach, Michael; Hubacek, Jaroslav A.; Slowikowski, Kamil; Raychaudhuri, Soumya; Kumar, Runjun D.; Harris, Tamara B.; Launer, Lenore J.; Shuldiner, Alan R.; Alonso, Alvaro; Bader, Joel S.; Ehret, Georg; Huang, Hailiang; Kao, W.H. Linda; Strait, James B.; Macfarlane, Peter W.; Brown, Morris; Caulfield, Mark J.; Samani, Nilesh J.; Kronenberg, Florian; Willeit, Johann; Smith, J. Gustav; Greiser, Karin H.; zu Schwabedissen, Henriette Meyer; Werdan, Karl; Carella, Massimo; Zelante, Leopoldo; Heckbert, Susan R.; Psaty, Bruce M.; Rotter, Jerome I.; Kolcic, Ivana; Polašek, Ozren; Wright, Alan F.; Griffin, Maura; Daly, Mark J.; Arnar, David O.; Hólm, Hilma; Thorsteinsdottir, Unnur; Denny, Joshua C.; Roden, Dan M.; Zuvich, Rebecca L.; Emilsson, Valur; Plump, Andrew S.; Larson, Martin G.; O'Donnell, Christopher J.; Yin, Xiaoyan; Bobbo, Marco; D'Adamo, Adamo P.; Iorio, Annamaria; Sinagra, Gianfranco; Carracedo, Angel; Cummings, Steven R.; Nalls, Michael A.; Jula, Antti; Kontula, Kimmo K.; Marjamaa, Annukka; Oikarinen, Lasse; Perola, Markus; Porthan, Kimmo; Erbel, Raimund; Hoffmann, Per; Jöckel, Karl-Heinz; Kälsch, Hagen; Nöthen, Markus M.; consortium, HRGEN; den Hoed, Marcel; Loos, Ruth J.F.; Thelle, Dag S.; Gieger, Christian; Meitinger, Thomas; Perz, Siegfried; Peters, Annette; Prucha, Hanna; Sinner, Moritz F.; Waldenberger, Melanie; de Boer, Rudolf A.; Franke, Lude; van der Vleuten, Pieter A.; Beckmann, Britt Maria; Martens, Eimo; Bardai, Abdennasser; Hofman, Nynke; Wilde, Arthur A.M.; Behr, Elijah R.; Dalageorgou, Chrysoula; Giudicessi, John R.; Medeiros-Domingo, Argelia; Barc, Julien; Kyndt, Florence; Probst, Vincent; Ghidoni, Alice; Insolia, Roberto; Hamilton, Robert M.; Scherer, Stephen W.; Brandimarto, Jeffrey; Margulies, Kenneth; Moravec, Christine E.; Fabiola Del, Greco M.; Fuchsberger, Christian; O'Connell, Jeffrey R.; Lee, Wai K.; Watt, Graham C.M.; Campbell, Harry; Wild, Sarah H.; El Mokhtari, Nour E.; Frey, Norbert; Asselbergs, Folkert W.; Leach, Irene Mateo; Navis, Gerjan; van den Berg, Maarten P.; van Veldhuisen, Dirk J.; Kellis, Manolis; Krijthe, Bouwe P.; Franco, Oscar H.; Hofman, Albert; Kors, Jan A.; Uitterlinden, André G.; Witteman, Jacqueline C.M.; Kedenko, Lyudmyla; Lamina, Claudia; Oostra, Ben A.; Abecasis, Gonçalo R.; Lakatta, Edward G.; Mulas, Antonella; Orrú, Marco; Schlessinger, David; Uda, Manuela; Markus, Marcello R.P.; Völker, Uwe; Snieder, Harold; Spector, Timothy D.; Ärnlöv, Johan; Lind, Lars; Sundström, Johan; Syvänen, Ann-Christine; Kivimaki, Mika; Kähönen, Mika; Mononen, Nina; Raitakari, Olli T.; Viikari, Jorma S.; Adamkova, Vera; Kiechl, Stefan; Brion, Maria; Nicolaides, Andrew N.; Paulweber, Bernhard; Haerting, Johannes; Dominiczak, Anna F.; Nyberg, Fredrik; Whincup, Peter H.; Hingorani, Aroon; Schott, Jean-Jacques; Bezzina, Connie R.; Ingelsson, Erik; Ferrucci, Luigi; Gasparini, Paolo; Wilson, James F.; Rudan, Igor; Franke, Andre; Mühleisen, Thomas W.; Pramstaller, Peter P.; Lehtimäki, Terho J.; Paterson, Andrew D.; Parsa, Afshin; Liu, Yongmei; van Duijn, Cornelia; Siscovick, David S.; Gudnason, Vilmundur; Jamshidi, Yalda; Salomaa, Veikko; Felix, Stephan B.; Sanna, Serena; Ritchie, Marylyn D.; Stricker, Bruno H.; Stefansson, Kari; Boyer, Laurie A.; Cappola, Thomas P.; Olsen, Jesper V.; Lage, Kasper; Schwartz, Peter J.; Kääb, Stefan; Chakravarti, Aravinda; Ackerman, Michael J.; Pfeufer, Arne; de Bakker, Paul I.W.; Newton-Cheh, Christopher

    2014-01-01

    The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal Mendelian Long QT Syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals we identified 35 common variant QT interval loci, that collectively explain ∼8-10% of QT variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 novel QT loci in 298 unrelated LQTS probands identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode for proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies novel candidate genes for ventricular arrhythmias, LQTS,and SCD. PMID:24952745

  19. Traffic paradox on a road segment based on a cellular automaton: Impact of lane-changing behavior

    Science.gov (United States)

    Feng, Shumin; Li, Jinyang; Ding, Ning; Nie, Cen

    2015-06-01

    The traffic paradox "faster is slower" does not always apply. To study when and where it is valid, a simulation for a real road segment is performed using a novel cellular automaton. This simulation is used to analyze the change in global traffic flow status during free lane-changing behavior under general urban traffic conditions. The impact of lane-changing behavior is quantified into two aspects, time and space, and are described by average delay and transitable flow, respectively. Then surfaces are obtained, which adopt the arriving probability of vehicles and the green ratio as dual independent variables. Thus by the comparison of two surfaces, free lane-changing and straight proceeding, the horizontal projection of the intersecting lines is solved. Finally, the range of occurrence and reasons for the paradox are analyzed.

  20. Measuring the Changes in Aggregate Cycling Patterns between 2003 and 2012 from a Space Syntax Perspective

    Directory of Open Access Journals (Sweden)

    Stephen Law

    2014-08-01

    Full Text Available There has been a world-wide surge of interest in cycling over the last 10 years of which London has seen a continuous growth in cyclists and investment in infrastructure that has resulted in the introduction of the Barclays Cycle Superhighway and Barclays Cycling Hiring Scheme. Despite the investment in cycling infrastructure, there has been little understanding of cycling activity patterns in general and the effect of spatial configuration on cycling route choices. This research aims at measuring the impact of cycling infrastructure and spatial configuration on aggregate cyclist movement over two time periods. To do so, this paper presents a spatial-based cyclist movement statistical model that regress cyclist movement flows with measure of spatial configuration, safety and infrastructure and urban character attributes. Using Elephant and Castle, a Central London location, as a case study, the authors analyze cycling movement data sets from 2003 and 2012 to compare the change in cycling behaviour and the impact that the Cycling Superhighway 07, introduced in 2011, has had on cycling patterns. Findings confirm the growth of cycling in London with a 1000% increase in cyclists along some routes in comparison to a 10% increase in population at the same time. More importantly, results also suggest that higher cyclist movement were observed along routes with greater convenience and continuity—over and above route segregation from vehicular traffic. The relationship between spatial configuration and aggregate cyclists movement is consistent between 2003 and 2012 where spatial configuration have remained the same while changes were observed in both modal split and cycling infrastructure. This result is in line with previous research wherein aggregate higher cyclists movement are observed on major routes offering direct connections than less direct routes. From a spatial cognition perspective, this research enriches our understanding on how the

  1. Safety-collision transition induced by lane changing in traffic flow

    International Nuclear Information System (INIS)

    We study the traffic behavior when a vehicle changes from the first lane to the second lane on a two-lane highway. We apply the optimal velocity model to the vehicular motion. If the incoming vehicle does not decelerate successfully, it crashes into the vehicle ahead. On the other hand, if the headway between the incoming vehicle and the vehicle behind on the second lane is not long sufficiently, the rear vehicle may come into collision with the incoming vehicle. The safety-collision transition occurs by changing the lane. The dynamical transition depends highly on the vehicular speed, the sensitivity, and the headway. We derive the phase diagram (or region map) for the safety-collision transition.

  2. Noncoding RNA mediated traffic of foreign mRNA into chloroplasts reveals a novel signaling mechanism in plants.

    Directory of Open Access Journals (Sweden)

    Gustavo Gómez

    Full Text Available Communication between chloroplasts and the nucleus is one of the milestones of the evolution of plants on earth. Proteins encoded by ancestral chloroplast-endogenous genes were transferred to the nucleus during the endosymbiotic evolution and originated this communication, which is mainly dependent on specific transit-peptides. However, the identification of nuclear-encoded proteins targeted to the chloroplast lacking these canonical signals suggests the existence of an alternative cellular pathway tuning this metabolic crosstalk. Non-coding RNAS (NcRNAs are increasingly recognized as regulators of gene expression as they play roles previously believed to correspond to proteins. Avsunviroidae family viroids are the only noncoding functional RNAs that have been reported to traffic inside the chloroplasts. Elucidating mechanisms used by these pathogens to enter this organelle will unearth novel transport pathways in plant cells. Here we show that a viroid-derived NcRNA acting as a 5'UTR-end mediates the functional import of Green Fluorescent Protein (GFP mRNA into chloroplast. This claim is supported by the observation at confocal microscopy of a selective accumulation of GFP in the chloroplast of the leaves expressing the chimeric vd-5'UTR/GFP and by the detection of the GFP mRNA in chloroplasts isolated from cells expressing this construct. These results support the existence of an alternative signaling mechanism in plants between the host cell and chloroplasts, where an ncRNA functions as a key regulatory molecule to control the accumulation of nuclear-encoded proteins in this organelle. In addition, our findings provide a conceptual framework to develop new biotechnological tools in systems using plant chloroplast as bioreactors. Finally, viroids of the family Avsunviroidae have probably evolved to subvert this signaling mechanism to regulate their differential traffic into the chloroplast of infected cells.

  3. Prediction of paroxysmal atrial fibrillation using recurrence plot-based features of the RR-interval signal

    International Nuclear Information System (INIS)

    Atrial fibrillation (AF) is the most common cardiac arrhythmia and increases the risk of stroke. Predicting the onset of paroxysmal AF (PAF), based on noninvasive techniques, is clinically important and can be invaluable in order to avoid useless therapeutic intervention and to minimize risks for the patients. In this paper, we propose an effective PAF predictor which is based on the analysis of the RR-interval signal. This method consists of three steps: preprocessing, feature extraction and classification. In the first step, the QRS complexes are detected from the electrocardiogram (ECG) signal and then the RR-interval signal is extracted. In the next step, the recurrence plot (RP) of the RR-interval signal is obtained and five statistically significant features are extracted to characterize the basic patterns of the RP. These features consist of the recurrence rate, length of longest diagonal segments (Lmax ), average length of the diagonal lines (Lmean), entropy, and trapping time. Recurrence quantification analysis can reveal subtle aspects of dynamics not easily appreciated by other methods and exhibits characteristic patterns which are caused by the typical dynamical behavior. In the final step, a support vector machine (SVM)-based classifier is used for PAF prediction. The performance of the proposed method in prediction of PAF episodes was evaluated using the Atrial Fibrillation Prediction Database (AFPDB) which consists of both 30 min ECG recordings that end just prior to the onset of PAF and segments at least 45 min distant from any PAF events. The obtained sensitivity, specificity, positive predictivity and negative predictivity were 97%, 100%, 100%, and 96%, respectively. The proposed methodology presents better results than other existing approaches

  4. A Sarsa(λ-Based Control Model for Real-Time Traffic Light Coordination

    Directory of Open Access Journals (Sweden)

    Xiaoke Zhou

    2014-01-01

    Full Text Available Traffic problems often occur due to the traffic demands by the outnumbered vehicles on road. Maximizing traffic flow and minimizing the average waiting time are the goals of intelligent traffic control. Each junction wants to get larger traffic flow. During the course, junctions form a policy of coordination as well as constraints for adjacent junctions to maximize their own interests. A good traffic signal timing policy is helpful to solve the problem. However, as there are so many factors that can affect the traffic control model, it is difficult to find the optimal solution. The disability of traffic light controllers to learn from past experiences caused them to be unable to adaptively fit dynamic changes of traffic flow. Considering dynamic characteristics of the actual traffic environment, reinforcement learning algorithm based traffic control approach can be applied to get optimal scheduling policy. The proposed Sarsa(λ-based real-time traffic control optimization model can maintain the traffic signal timing policy more effectively. The Sarsa(λ-based model gains traffic cost of the vehicle, which considers delay time, the number of waiting vehicles, and the integrated saturation from its experiences to learn and determine the optimal actions. The experiment results show an inspiring improvement in traffic control, indicating the proposed model is capable of facilitating real-time dynamic traffic control.

  5. A Sarsa(λ)-based control model for real-time traffic light coordination.

    Science.gov (United States)

    Zhou, Xiaoke; Zhu, Fei; Liu, Quan; Fu, Yuchen; Huang, Wei

    2014-01-01

    Traffic problems often occur due to the traffic demands by the outnumbered vehicles on road. Maximizing traffic flow and minimizing the average waiting time are the goals of intelligent traffic control. Each junction wants to get larger traffic flow. During the course, junctions form a policy of coordination as well as constraints for adjacent junctions to maximize their own interests. A good traffic signal timing policy is helpful to solve the problem. However, as there are so many factors that can affect the traffic control model, it is difficult to find the optimal solution. The disability of traffic light controllers to learn from past experiences caused them to be unable to adaptively fit dynamic changes of traffic flow. Considering dynamic characteristics of the actual traffic environment, reinforcement learning algorithm based traffic control approach can be applied to get optimal scheduling policy. The proposed Sarsa(λ)-based real-time traffic control optimization model can maintain the traffic signal timing policy more effectively. The Sarsa(λ)-based model gains traffic cost of the vehicle, which considers delay time, the number of waiting vehicles, and the integrated saturation from its experiences to learn and determine the optimal actions. The experiment results show an inspiring improvement in traffic control, indicating the proposed model is capable of facilitating real-time dynamic traffic control. PMID:24592183

  6. Traffic Monitoring and Control Using RFID

    Directory of Open Access Journals (Sweden)

    Gaurav Thakur

    2013-09-01

    Full Text Available Traffic congestion and tidal flow management were recognized as major problems in modern urban areas, which have caused much frustration and loss of man hours. The operation of standard traffic lights which are currently deployed in many junctions, are based on predetermined timing schemes, which are fixed during the installation and remain until further resetting. The timing is no more than a default setup to control what may be considered as normal traffic. Although every road junction by necessity requires different traffic light timing setup, many existing systems operate with a default sequence. To design an intelligent and efficient traffic control system, a number of parameters that represent the status of the road conditions must be identified and taken into consideration. Approach: In order to solve the problem an intelligent RFID traffic control has been developed. This project is based on monitoring the traffic density at the signal using RFID Reader. RFID tags which is placed (instead of number plate at each vehicle will serve as the unique number of vehicle .Reader will count the number of tags at the signal and take decision of increasing or decreasing the signal time .This reader is also use to find the violation(VIN of violator of the signal. Each passive tag will have certain number of bytes information will be different for different vehicles. Whenever any tag will approach any signal, reader will take that bytes of information and simultaneously will also increment the number of vehicles for making decision to change the signal timing. Each tag of data will be stored in main memory (database.This unique data will also help in determining the violator of the signal .Thus it will save human efforts and resources to a greater extent and reduce waiting of the people at the signal. After implementation of this project, now all people waiting at the signal will get proper time (green light according to the traffic density

  7. Have drivers at alcohol outlets changed their behavior after the new traffic law?

    Directory of Open Access Journals (Sweden)

    Raquel B. De Boni

    2014-03-01

    Full Text Available Objective: In an attempt to reduce high levels of traffic crashes, a new legislation was approved in Brazil in 2008. This study aimed to assess behavioral change among drivers who had drunk at alcohol outlets (AO after implementation of the law. Method: A three-stage probability sampling survey was conducted in Porto Alegre, state of Rio Grande do Sul, Brazil. Individuals seen leaving AOs after drinking were approached (n=3,018. Selected drivers (n=683 answered a structured interview, were breathalyzed, and had saliva specimens collected for drug screening. Results: Overall, 60.3% (SE 4.5 of drivers reported they did not change their behavior. Among those who reported behavioral changes, most reported drinking less as their main strategy toward safer driving behavior. Variables independently associated with behavior change included having drunk at a high outlet density area (odds ratio [OR] 1.7 [1.1-2.8] and having a favorable opinion about the law (OR 4.3 [2.1-8.9]. Conclusions: Our findings suggest that awareness of the law has not been enough to promote behavioral change. As most drivers had a favorable opinion of the law and this variable was found to be the strongest predictor of behavior change, efforts to better integrate education and enforcement seem to be pivotal and might be well received by the population.

  8. Low cadence interval training at moderate intensity does not improve cycling performance in highly trained veteran cyclists

    Directory of Open Access Journals (Sweden)

    Morten eKristoffersen

    2014-01-01

    Full Text Available Purpose: The aim of the present study was to investigate effects of low cadence training at moderate intensity on aerobic capacity, cycling performance, gross efficiency, freely chosen cadence and leg strength in veteran cyclists. Method: Twenty-two well trained veteran cyclists (age: 47 ±6 years, maximal oxygen consumption (VO2max: 57.9 ±3.7 ml. kg-1. min-1 were randomized into two groups, a low cadence training group and a freely chose cadence training group. Respiratory variables, power output, cadence and leg strength were tested before and after a 12 weeks training intervention period. The low cadence training group performed 12 weeks of moderate (73-82 % of maximal heart rate (HRmax interval training (5 x 6 min with a cadence of 40 revolutions per minute (rpm two times a week, in addition to their usual training. The freely chosen cadence group added 90 minutes of training at freely chosen cadence at moderate intensity. Results: No significant effects of the low cadence training on aerobic capacity, cycling performance, power output, cadence, gross efficiency or leg strength was found. The freely chosen cadence group significantly improved both VO2max (58.9±2.4 vs. 62.2±3.2 ml. kg-1. min-1, VO2 consumption at lactate threshold (49.4 ±3.8 vs. 51.8±3.5 ml. kg-1. min-1 and during the 30 min performance test (52.8±3.0 vs. 54.7±3.5 ml. kg-1. min-1, and power output at lactate threshold (284 ±47 vs. 294 ±48 W and during the 30 min performance test (284±42 vs. 297±50 W. Conclusion: Twelve weeks of low cadence (40 rpm interval training at moderate intensity (73-82 % of HRmax twice a week does not improve aerobic capacity, cycling performance or leg strength in highly trained veteran cyclists. However, adding training at same intensity (% of HRmax and duration (90 minutes weekly at freely chosen cadence seems beneficial for performance and physiological adaptations.

  9. Climate Change and Expected Impacts on the Global Water Cycle

    Science.gov (United States)

    Rind, David; Hansen, James E. (Technical Monitor)

    2002-01-01

    How the elements of the global hydrologic cycle may respond to climate change is reviewed, first from a discussion of the physical sensitivity of these elements to changes in temperature, and then from a comparison of observations of hydrologic changes over the past 100 million years. Observations of current changes in the hydrologic cycle are then compared with projected future changes given the prospect of global warming. It is shown that some of the projections come close to matching the estimated hydrologic changes that occurred long ago when the earth was very warm.

  10. Multiple and changing cycles of active stars II. Results

    CERN Document Server

    Oláh, K; Granzer, T; Strassmeier, K G; Lanza, A F; Järvinen, S; Korhonen, H; Baliunas, S L; Soon, W; Messina, S; Cutispoto, G

    2009-01-01

    We study the time variations of the cycles of 20 active stars based on decades-long photometric or spectroscopic observations. A method of time-frequency analysis, as discussed in a companion paper, is applied to the data. Fifteen stars definitely show multiple cycles; the records of the rest are too short to verify a timescale for a second cycle. The cycles typically show systematic changes. For three stars, we found two cycles in each of them that are not harmonics, and which vary in parallel, indicating that a common physical mechanism arising from a dynamo construct. The positive relation between the rotational and cycle periods is confirmed for the inhomogeneous set of active stars. Stellar activity cycles are generally multiple and variable.

  11. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

    NARCIS (Netherlands)

    Peeper, D.S.; Upton, T.M.; Ladha, M.H.; Neuman, E.; Zalvide, J.; Bernards, R.A.; DeCaprio, J.A.; Ewen, M.E.

    1997-01-01

    The Ras proto-oncogene is a central component of mitogenic signal-transduction pathways, and is essential for cells both to leave a quiescent state (GO) and to pass through the GI/S transition of the cell cycle. The mechanism by which Ras signalling regulates cell-cycle progression is unclear, howev

  12. Signal Controlled Urban Traffic Network Model with Random Update Rule%信号灯随机更新的城市交通网络模型

    Institute of Scientific and Technical Information of China (English)

    盘薇; 贾丽斯; 薛郁

    2016-01-01

    【目的】改进二维元胞自动机模型(BML模型),使其更好模拟实际城市交通网络。【方法】利用元胞自动机方法,建立信号灯随机更新的城市交通网络模型。【结果】数值模拟发现,信号灯的同步对城市交通网络的影响较大,且随机更新的引入使得网络系统的临界密度大幅度降低。【结论】同时调整信号灯的分布和信号变换周期能有效控制交通网络,解决由于信号灯随机更新所造成的系统临界密度变小的问题。%Objective]An improved two-dimensional cellular automaton model (BML model) was proposed to better simulate real urban traffic network.[Methods]Aiming at the urban traf-fic congestion problem and using the cellular automata method,a traffic signal model with ran-dom update rule was established to study the urban traffic network.[Results]Simulation results showed that the synchronization of the traffic signal has great influence on the traffic system, and the introduction of random update rule significantly reduces the critical density of phase transition.[Conclusion]When the roads are crowed by cars,simultaneous adj usting of signal ar-rangements and periods provides a possible way for relaxing the traffic congestion.

  13. Transition from Disorder to Order in Traffic Flow

    Institute of Scientific and Technical Information of China (English)

    LI Ke-Ping; GAO Zi-You

    2004-01-01

    We propose a new technique to investigate the dynamical transitions among the traffic phases. A type of the control signals has been designated at a given site (signal point) of the single-lane highway. Under the effect of the control signal, the velocity of the vehicle that passes the signal point will be changed periodically. Our method is tested for the deterministic NaSch traffic model. The simulation results demonstrate that the disorder states in the deterministic NaSch traffic model can be suppressed, and the different types of periodic states would occur.

  14. Prognostic value of QTc interval dispersion changes during exercise testing in hypertensive men

    Directory of Open Access Journals (Sweden)

    Đorđević Dragan

    2008-01-01

    Full Text Available INTRODUCTION The prognostic significance of QTc dispersion changes during exercise testing (ET in patients with left ventricular hypertrophy is not clear. OBJECTIVE The aim was to study the dynamics of QTc interval dispersion (QTcd in patients (pts with left ventricular hypertrophy (LVH during the exercise testing and its prognostic significance. METHOD In the study we included 55 men (aged 53 years with hypertensive left ventricular hypertrophy and a negative ET (LVH group, 20 men (aged 58 years with a positive ET and 20 healthy men (aged 55 years. There was no statistically significant difference in the left ventricular mass index (LVMI between LVH group and ILVH group (160.9±14.9 g/m2 and 152.8±22.7 g/m2. The first ECG was done before the ET and the second one was done during the first minute of recovery, with calculation of QTc dispersion. The patients were followed during five years for new cardiovascular events. RESULTS During the ET, the QTcd significantly increased in LVH group (56.8±18.0 - 76.7±22.6 ms; p<0.001. A statistically significant correlation was found between the amount of ST segment depression at the end of ET and QTc dispersion at the beginning and at the end of ET (r=0.673 and r=0.698; p<0.01. The QTc dispersion was increased in 35 (63.6% patients and decreased in 20 (36.4% patients during the ET. Three patients (5.4% in the first group had adverse cardiovascular events during the five-year follow-up. A multiple stepwise regression model was formed by including age, LVMI, QTc interval, QTc dispersion and change of QTc dispersion during the ET. There was no prognostic significance of QTc interval and QTc dispersion during five-year follow-up in regard to adverse cardiovascular events, but prognostic value was found for LVMI (coefficient β=0.480; p<0.001. CONCLUSION The increase of QTc interval dispersion is common in men with positive ET for myocardial ischemia and there is a correlation between QTc dispersion and

  15. Frequency and duration of interval training programs and changes in aerobic power

    Science.gov (United States)

    Fox, E. L.; Bartels, R. L.; Obrien, R.; Bason, R.; Mathews, D. K.; Billings, C. E.

    1975-01-01

    The present study was designed to ascertain whether a training frequency of 2 days/wk for a 7- and 13-wk interval training program would produce improvement in maximal aerobic power comparable to that obtained from 7- and 13-wk programs of the same intensity consisting of 4 training days/wk. After training, there was a significant increase in maximal aerobic power that was independent of both training frequency and duration. Maximal heart rate was significantly decreased following training. Submaximal aerobic power did not change with training, but submaximal heart rate decreased significantly with greater decreases the more frequent and the longer the training.

  16. Empirical Study of Accepted Gap and Lane Change Duration within Arterial Traffic under Recurrent and Non-Recurrent Congestion

    Directory of Open Access Journals (Sweden)

    Saravanan Gurupackiam

    2012-12-01

    Full Text Available This paper investigated variations in accepted gaps and lane change duration on arterial under recurrent and non-recurrent congestion. Descriptive statistics and best-fit distributions were obtained for the two parameters for both traffic conditions. Hypothesis testing using Mann-Whitney U-Test showed that the means of accepted gaps and lane change durations were statistically different between the two types of traffic’ conditions. The study found that during non-recurrent congestion, drivers on an average accepted smaller gaps but took longer lane change durations. Based on the fact that the data were collected for the same flow-rate (70-90 vehicles/minute in both traffic conditions and based on the literature, the reason for the above findings could be that, drivers get more frustrated during non-recurring congestion that they accept smaller gaps. Drivers visiting the study location for game day (non-recurrent exhibit different driver behavioral characteristics when compared to regular commuters (recurrent which could have also contributed to the statistical differences in the lane changing characteristics of two types of congestion. These findings have direct implications on the lane changing parameters used in microscopic traffic simulation and also help transportation planners and managers to understand driver behavior during recurrent and non-recurrent congestion and better manage the facilities.

  17. MQ-MAC: a multi-constrained QoS-aware duty cycle MAC for heterogeneous traffic in wireless sensor networks.

    Science.gov (United States)

    Monowar, Muhammad Mostafa; Rahman, Md Obaidur; Hong, Choong Seon; Lee, Sungwon

    2010-01-01

    Energy conservation is one of the striking research issues now-a-days for power constrained wireless sensor networks (WSNs) and hence, several duty-cycle based MAC protocols have been devised for WSNs in the last few years. However, assimilation of diverse applications with different QoS requirements (i.e., delay and reliability) within the same network also necessitates in devising a generic duty-cycle based MAC protocol that can achieve both the delay and reliability guarantee, termed as multi-constrained QoS, while preserving the energy efficiency. To address this, in this paper, we propose a Multi-constrained QoS-aware duty-cycle MAC for heterogeneous traffic in WSNs (MQ-MAC). MQ-MAC classifies the traffic based on their multi-constrained QoS demands. Through extensive simulation using ns-2 we evaluate the performance of MQ-MAC. MQ-MAC provides the desired delay and reliability guarantee according to the nature of the traffic classes as well as achieves energy efficiency.

  18. MQ-MAC: A Multi-Constrained QoS-Aware Duty Cycle MAC for Heterogeneous Traffic in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Sungwon Lee

    2010-11-01

    Full Text Available Energy conservation is one of the striking research issues now-a-days for power constrained wireless sensor networks (WSNs and hence, several duty-cycle based MAC protocols have been devised for WSNs in the last few years. However, assimilation of diverse applications with different QoS requirements (i.e., delay and reliability within the same network also necessitates in devising a generic duty-cycle based MAC protocol that can achieve both the delay and reliability guarantee, termed as multi-constrained QoS, while preserving the energy efficiency. To address this, in this paper, we propose a Multi-constrained QoS-aware duty-cycle MAC for heterogeneous traffic in WSNs (MQ-MAC. MQ-MAC classifies the traffic based on their multi-constrained QoS demands. Through extensive simulation using ns-2 we evaluate the performance of MQ-MAC. MQ-MAC provides the desired delay and reliability guarantee according to the nature of the traffic classes as well as achieves energy efficiency.

  19. 一种新型嵌入式网络信号机研究与设计%Study and Design of Embedded Network Traffic Signal Controller

    Institute of Scientific and Technical Information of China (English)

    肖圣兵; 陈锋

    2012-01-01

    Traffic signal controller is one of the main foundations for Intelligent Traffic System. In order to meet intellectualization and network requirements, a novel embedded network signal controller is investigated. ARM and CPLD are used to design hardware structure of signal controller, and humanized user interface is developed using QT/Embedded based on touch screen. Multiple communication interfaces are supported and the communication protocol is defined by XML. The mode of two level conflict check is introduced to avoid green conflict. Single point fuzzy control module is developed to deal with dynamic traffic flow, so as to increase traffic capacity in intersection. Connecting to traffic simulation software that simulates the actual intersectiont experiments show that traffic signal controller works stably, and has excellent performance.%交通信号机是智能交通系统的基础之一,为了满足信号机的网络化和智能化的要求,研究并提出了一种新型的嵌入式网络信号机,该信号机的硬件结构采用ARM和CPLD,以触摸屏为基础采用QT/Embedded设计了人性化的人机接口,信号机支持多种通信接口,其协议采用XML予以定义;为了避免绿冲突,以两级模式进行冲突判断;单点模糊控制机制的设计能够适应动态的交通流状况,有效提高交叉口的通行能力;连接交通仿真软件,模拟实际路口,实验显示该信号机工作稳定,性能优越.

  20. Small signal with background: objective confidence intervals and regions for physical parameters from the principle of maximum likelihood

    International Nuclear Information System (INIS)

    It is argued that the choice between one-sided and two-sided confidence intervals must be made according to a rule prior to and independent of the data and it is shown that such a rule was found in principle by a statistician about half a century ago. The novel problem with unphysical estimates of a parameter in presence of background is solved in the realm of classical statistics by applying this rule and the principle of maximum likelihood. Optimal confidence intervals are given for the measurement of a bounded magnitude with normal errors, most effective in discriminating a signal next to the bound, and it is shown how to get them in any single case for a bounded discrete variable with background, in general and specifically for Poisson and binomial variables, with two examples of application. The upper limit provided by this method, when the data are consistent with no signal, does not decrease with unphysical estimates going far off the physical values, so removing the last claimed support of Bayesian inference in physics. Procedure are given extending the method to several parameters

  1. Ultra-narrow interval angular control signal for holographic data storage system

    Science.gov (United States)

    Yamazaki, Kazuyoshi; Hosaka, Makoto; Yamada, Kenichiro; Ogata, Takeshi; Shimada, Kenichi

    2016-08-01

    A precise and fast method for controlling the reference-beam angle of an angular-multiplexed holographic data storage system (HDSS)—to achieve larger capacity and faster data-transfer rate—is proposed. The reference beam is first controlled by a galvanometer mirror (GM) with an "angular control signal (ACS)" applied to its zero-cross angle (which differs by a certain offset angle from the target angle). The offset angle is then eliminated by referring to the output from a rotary encoder inside the GM, and the optimum angle for the reference beam is obtained. Next, a servo beam is used for the ACS, and the ACS value is obtained as a differential signal between the beam intensities of the diffracted reference beam and the diffracted servo beam. The servo beam is orthogonally polarized in regard to the reference beam and has a slightly different incident angle. A reference-beam angular error lower than 3.3 mdeg was confirmed in simulations and experiments.

  2. Behavior Change Techniques Used to Promote Walking and Cycling

    OpenAIRE

    Bird, Emma L.; Baker, Graham; Mutrie, Nanette; Ogilvie, David; Sahlqvist, Shannon; Powell, Jane

    2013-01-01

    Objective: Evidence on the effectiveness of walking and cycling interventions is mixed. This may be partly attributable to differences in intervention content, such as the cognitive and behavioral techniques (BCTs) used. Adopting a taxonomy of BCTs, this systematic review addressed two questions: (a) What are the behavior change techniques used in walking and cycling interventions targeted at adults? (b) What characterizes interventions that appear to be associated with changes in walking and...

  3. 车流量检测雷达系统信号处理研究%TRAFFIC FLOW MEASUREMENT RADAR SYSTEM SIGNAL PROCESSING RESEARCH

    Institute of Scientific and Technical Information of China (English)

    李秦君; 党宏社

    2011-01-01

    Designs one kind the traffic flow measurement radar system which as an input source of intelligent transport system, based on DSP technology to achieve an integrated signal processing, while using the feature which radar wave intermediate frequency signal contains information about how far from the object to radar, applies the related algorithm to carry on the spectral analysis to the intermediate frequency signal, to obtained access to the traffic lane information and the traffic flow statistics. Designed to achieve signal processing, traffic statistics and serial communication software system.%设计一种作为智能交通系统输入信息来源的车流量检测雷达系统,采用基于DSP的技术实现信号的综合处理,利用雷达波中频信号中包含了物体距离雷达有多远的信息这一特性,应用相关算法对中频信号进行频谱分析,获得车道信息并进行车流量统计.设计了实现系统信号处理、车流量统计及串口通信的软件系统.

  4. Traffic Information System for Hanoi

    OpenAIRE

    Sohr, Alexander; Brockfeld, Elmar; Sauerländer-Biebl, Anke; Melde, Eric

    2016-01-01

    To improve the traffic situation in Hanoi it is necessary to have a good overview of the existing traffic situation and to monitor the development of the traffic over longer time periods. Floating Car Data (FCD) Systems can help to acquire area wide traffic information; here a FCD system based on taxis, busses and motor-cycles is described. It consists of Web and App tools and a Hotspot-Monitoring for long term traffic analysis.

  5. “Full monty” or low-key : Two traffic management approaches and their effect on change perception

    NARCIS (Netherlands)

    Harms, Ilse; Brookhuis, Karel; de Waard, Dick; Brookhuis, Karel; Wiczorek, Rebecca; di Nocera, Francesco; Brouwer, Rino; Barham, Philip; Weikert, Clemens; Kluge, Annette; Gerbino, Walter; Toffetti, Antonella

    2014-01-01

    European road authorities differ in their views on whether variable-message signs (VMSs) can be in use continually or that they should only display information when necessary. This study compared the two approaches in terms of the ease with which drivers perceive changes in traffic management inform

  6. Two dimensional mixed traffic flow considering the transit traffic

    OpenAIRE

    Lingjiang Kong; Junhui Hu; Li Yang

    2012-01-01

    Based on the two-dimension cellular automaton traffic flow model (BML model), a mixed traffic flow model for urban traffic considering the transit traffic is established in this paper by using the Don't block the box rules. We have investigated the influences of the transit traffic ratio, and found that, in most cases, the urban traffic flow exhibited jam phase. Moreover, focusing on the traffic lights cycle, it is found that the average flow has the periodic fluctuation phenomenon, and we ha...

  7. The anti-motility signaling mechanism of TGFβ3 that controls cell traffic during skin wound healing

    Directory of Open Access Journals (Sweden)

    Arum Han

    2012-09-01

    When skin is wounded, migration of epidermal keratinocytes at the wound edge initiates within hours, whereas migration of dermal fibroblasts toward the wounded area remains undetectable until several days later. This “cell type traffic” regulation ensures proper healing of the wound, as disruptions of the regulation could either cause delay of wound healing or result in hypertrophic scars. TGFβ3 is the critical traffic controller that selectively halts migration of the dermal, but not epidermal, cells to ensure completion of wound re-epithelialization prior to wound remodeling. However, the mechanism of TGFβ3's anti-motility signaling has never been investigated. We report here that activated TβRII transmits the anti-motility signal of TGFβ3 in full to TβRI, since expression of the constitutively activated TβRI-TD mutant was sufficient to replace TGFβ3 to block PDGF-bb-induced dermal fibroblast migration. Second, the three components of R-Smad complex are all required. Individual downregulation of Smad2, Smad3 or Smad4 prevented TGFβ3 from inhibiting dermal fibroblast migration. Third, Protein Kinase Array allowed us to identify the protein kinase A (PKA as a specific downstream effector of R-Smads in dermal fibroblasts. Activation of PKA alone blocked PDGF-bb-induced dermal fibroblast migration, just like TGFβ3. Downregulation of PKA's catalytic subunit nullified the anti-motility signaling of TGFβ3. This is the first report on anti-motility signaling mechanism by TGFβ family cytokines. Significance of this finding is not only limited to wound healing but also to other human disorders, such as heart attack and cancer, where the diseased cells have often managed to avoid the anti-motility effect of TGFβ.

  8. Postmortem Changes in Animal Carcasses and Estimation of the Postmortem Interval.

    Science.gov (United States)

    Brooks, J W

    2016-09-01

    A thorough understanding of the physical and chemical changes that occur in the body after death is critical for accurate interpretation of gross and microscopic pathology at autopsy. Furthermore, knowledge of the postmortem processes and the factors that affect them will aid in the estimation of the postmortem interval (PMI). The estimation of the PMI is important in many human and animal death investigations. Despite many decades of research, accuracy in estimation of the time of death has not significantly improved, and no single method can be reliably used to accurately estimate the time of death. Great care should be taken when formulating such an estimate, for it is dependent on multiple circumstantial and environmental factors, and the accuracy and precision of the estimate decrease as the PMI increases. The majority of the research in the field has been conducted on human bodies, but many relevant conclusions may be drawn regarding the expected postmortem changes in animals and the estimation of the PMI. The veterinary pathologist must use great caution when attempting to extrapolate data and apply formulas designed for use in humans. Methods reviewed include gross changes, microscopic changes, temperature-based methods, postmortem chemistry, molecular methods, microbial assay, ocular changes, radiography, entomology, and others. Although only several of these methods are currently practical for use in the workup of cases, it is expected that future research will result in improved techniques with enhanced accuracy in the estimation of the PMI, which will benefit both human and veterinary forensic investigations. PMID:26945004

  9. Traffic-flow simulation

    OpenAIRE

    OMAHEN, ANDRAŽ

    2015-01-01

    This diploma thesis presents the behavior of program, which uses the traffic light enhanced transport network to simulate the traffic flow of vehicles that behave according to the IDM model. We upgraded the program to allow, for the given network, to optimize the traffic flow. Because of the overwhelming problem of road closures or their rearrangement, we added a graphical user interface with which a user can create or modify the road network to observe changes in traffic. The objective of...

  10. Avoidance Expression in Rats as a Function of Signal-Shock Interval: Strain and Sex Differences

    Directory of Open Access Journals (Sweden)

    Richard J Servatius

    2015-07-01

    Full Text Available Inbred Wistar Kyoto (WKY rats express inhibited temperament, increased sensitivity to stress, and exaggerated expressions of avoidance. A long-standing observation for lever press escape/avoidance learning in rats is the duration of the warning signal (WS determines whether avoidance is expressed over escape. Outbred female Sprague-Dawley (SD rats trained with a 10-s WS efficiently escaped, but failed to exhibit avoidance; avoidance was exhibited to a high degree with WSs longer than 20-s. We examined this longstanding WS duration function and extended it to male SD and male and female WKY rats. A cross-over design with two WS durations (10 s or 60 s was employed. Rats were trained (20 trials/session in four phases: acquisition (10 sessions, extinction (10 sessions, re-acquisition (8 sessions and re-extinction (8 sessions. Consistent with the literature, female and male SD rats failed to express avoidance to an appreciable degree with a 10-s WS. When these rats were switched to a 60-s WS, performance levels in the initial session of training resembled the peak performance of rats trained with a 60-s WS. Therefore, the avoidance relationship was acquired, but not expressed at 10-s WS. Further, poor avoidance at 10-s does not adversely affect expression at 60-s. Failure to express avoidance with a 10-s WS likely reflects contrasting reinforcement value of avoidance, not a reduction in the amount of time available to respond or competing responses. In contrast, WKY rats exhibited robust avoidance with a 10-s WS, which was most apparent in female WKY rats. Exaggerated expression of avoidances by WKY rats, especially female rats, further confirms this inbred strain as a model of anxiety vulnerability.

  11. Change of translational-rotational coupling in liquids revealed by field-cycling 1H NMR

    International Nuclear Information System (INIS)

    Applying the field-cycling nuclear magnetic resonance technique, the frequency dependence of the 1H spin-lattice relaxation rate, R1(ω)=T1−1(ω), is measured for propylene glycol (PG) which is increasingly diluted with deuterated chloroform. A frequency range of 10 kHz–20 MHz and a broad temperature interval from 220 to about 100 K are covered. The results are compared to those of experiments, where glycerol and o-terphenyl are diluted with their deuterated counter-part. Reflecting intra- as well as intermolecular relaxation, the dispersion curves R1(ω,x) (x denotes mole fraction PG) allow to extract the rotational time constant τrot(T, x) and the self-diffusion coefficient D(T, x) in a single experiment. The Stokes-Einstein-Debye (SED) relation is tested in terms of the quantity D(T, x) τrot(T, x) which provides a measure of an effective hydrodynamic radius or equivalently of the spectral separation of the translational and the rotational relaxation contribution. In contrast to o-terphenyl, glycerol and PG show a spectral separation much larger than suggested by the SED relation. In the case of PG/chloroform mixtures, not only an acceleration of the PG dynamics is observed with increasing dilution but also the spectral separation of rotational and translational relaxation contributions continuously decreases. Finally, following a behavior similar to that of o-terphenyl already at about x = 0.6; i.e., while D(T, x) τrot(T, x) in the mixture is essentially temperature independent, it strongly increases with x signaling thus a change of translational-rotational coupling. This directly reflects the dissolution of the hydrogen-bond network and thus a change of solution structure

  12. Controlling Disorder in Traffic Flow by Perturbation

    Institute of Scientific and Technical Information of China (English)

    LI Ke-Ping; GAO Zi-You; CHEN Tian-Lun

    2004-01-01

    We propose a new technique for controlling disorder in traffic system. A kind of control signal which can be considered as a perturbation has been designated at a given site (perturbation point) of the single-lane highway. When a vehicle passes the perturbation point at a time, the velocity of the vehicle will be changed at the next time by the perturbation. This technique is tested for the deterministic NaSch traffic model. The simulation results indicate that the traffic system can be transited from the disorder states to the order states, such as fixed-point, periodic motion, etc.

  13. Trace Analysis of Driver Behavior on Traffic Violator by Using Big Data (Traffic Program) in Korea

    OpenAIRE

    Lee, Jonghak

    2016-01-01

    This study aims to prove the effectiveness of traffic safety education program for traffic violators. Traffic violators who finished the traffic safety education programs were tracked down. In order to analyze the effectiveness of traffic safety education program, traffic violator’s data during ten-year period were used. This study analyzed how traffic violators changed their attitudes about traffic law abidance. Also predicted social benefits from traffic safety education program...

  14. Evaluating therapeutic outcome in epileptic patients using the changes of interval and duration

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: Seizure frequency is in abnormal distribution, and it is not enough to express the trend of concentration using means, and its median loses a lot of information, thus it lacks of a standard for evaluating the therapeutic effects based on seizure frequency.OBJECTIVE: To establish a method for evaluating the therapeutic effects on anti-epileptic drugs using changes of interval and duration of seizure.DESIGN: A prospective cohort study.SETTING: Zhumadian Psychiatric Hospital.PARTICIPANTS: Outpatients and inpatients suffering from epilepsy attending firstly visited Zhumadian Psychiatric Hospital from June 2001 to June 2002 were enrolled. They were diagnosed as epileptic according to the International Classification of Epileptic Seizure by International League Against Epilepsy (1981) based on the clinical history, physical examination, and investigations. The interval time was no more than 6 months. Informed consent was obtained from all the subjects, and the study was approved by the hospital ethical committee.METHODS: ① For the first visit and each follow-up, the following data were recorded, including general demographic information, seizure type, the date and time of ictus, the duration of ictus, and inducement or situation related, according to which the following indexes could be calculated, including seizure styles,interval, duration, cluster frequency and cluster duration. The information from the first review was noted as annals A. The second interview was taken at the end of the evaluating period; the information from the second review was noted as annals B. The third interview was taken within two weeks after the second one;the information from the third review was noted as annals C. The annals B or the annals C were respectively compared with the annals A in the light of the same types or the same styles of the same patient. Summation of the scores of interval change and duration change of the same type or the same style and 5 of basic score

  15. Changing Biomass, Fossil, and Nuclear Fuel Cycles for Sustainability

    International Nuclear Information System (INIS)

    The energy and chemical industries face two great sustainability challenges: the need to avoid climate change and the need to replace crude oil as the basis of our transport and chemical industries. These challenges can be met by changing and synergistically combining the fossil, biomass, and nuclear fuel cycles.

  16. Concurrent exercise incorporating high-intensity interval or continuous training modulates mTORC1 signaling and microRNA expression in human skeletal muscle.

    Science.gov (United States)

    Fyfe, Jackson J; Bishop, David J; Zacharewicz, Evelyn; Russell, Aaron P; Stepto, Nigel K

    2016-06-01

    We compared the effects of concurrent exercise, incorporating either high-intensity interval training (HIT) or moderate-intensity continuous training (MICT), on mechanistic target of rapamycin complex 1 (mTORC1) signaling and microRNA expression in skeletal muscle, relative to resistance exercise (RE) alone. Eight males (mean ± SD: age, 27 ± 4 yr; V̇o2 peak , 45.7 ± 9 ml·kg(-1)·min(-1)) performed three experimental trials in a randomized order: 1) RE (8 × 5 leg press repetitions at 80% 1-repetition maximum) performed alone and RE preceded by either 2) HIT cycling [10 × 2 min at 120% lactate threshold (LT); HIT + RE] or 3) work-matched MICT cycling (30 min at 80% LT; MICT + RE). Vastus lateralis muscle biopsies were obtained immediately before RE, either without (REST) or with (POST) preceding endurance exercise and +1 h (RE + 1 h) and +3 h (RE + 3 h) after RE. Prior HIT and MICT similarly reduced muscle glycogen content and increased ACC(Ser79) and p70S6K(Thr389) phosphorylation before subsequent RE (i.e., at POST). Compared with MICT, HIT induced greater mTOR(Ser2448) and rps6(Ser235/236) phosphorylation at POST. RE-induced increases in p70S6K and rps6 phosphorylation were not influenced by prior HIT or MICT; however, mTOR phosphorylation was reduced at RE + 1 h for MICT + RE vs. both HIT + RE and RE. Expression of miR-133a, miR-378, and miR-486 was reduced at RE + 1 h for HIT + RE vs. both MICT + RE and RE. Postexercise mTORC1 signaling following RE is therefore not compromised by prior HIT or MICT, and concurrent exercise incorporating HIT, but not MICT, reduces postexercise expression of miRNAs implicated in skeletal muscle adaptation to RE. PMID:27101297

  17. Concurrent exercise incorporating high-intensity interval or continuous training modulates mTORC1 signaling and microRNA expression in human skeletal muscle.

    Science.gov (United States)

    Fyfe, Jackson J; Bishop, David J; Zacharewicz, Evelyn; Russell, Aaron P; Stepto, Nigel K

    2016-06-01

    We compared the effects of concurrent exercise, incorporating either high-intensity interval training (HIT) or moderate-intensity continuous training (MICT), on mechanistic target of rapamycin complex 1 (mTORC1) signaling and microRNA expression in skeletal muscle, relative to resistance exercise (RE) alone. Eight males (mean ± SD: age, 27 ± 4 yr; V̇o2 peak , 45.7 ± 9 ml·kg(-1)·min(-1)) performed three experimental trials in a randomized order: 1) RE (8 × 5 leg press repetitions at 80% 1-repetition maximum) performed alone and RE preceded by either 2) HIT cycling [10 × 2 min at 120% lactate threshold (LT); HIT + RE] or 3) work-matched MICT cycling (30 min at 80% LT; MICT + RE). Vastus lateralis muscle biopsies were obtained immediately before RE, either without (REST) or with (POST) preceding endurance exercise and +1 h (RE + 1 h) and +3 h (RE + 3 h) after RE. Prior HIT and MICT similarly reduced muscle glycogen content and increased ACC(Ser79) and p70S6K(Thr389) phosphorylation before subsequent RE (i.e., at POST). Compared with MICT, HIT induced greater mTOR(Ser2448) and rps6(Ser235/236) phosphorylation at POST. RE-induced increases in p70S6K and rps6 phosphorylation were not influenced by prior HIT or MICT; however, mTOR phosphorylation was reduced at RE + 1 h for MICT + RE vs. both HIT + RE and RE. Expression of miR-133a, miR-378, and miR-486 was reduced at RE + 1 h for HIT + RE vs. both MICT + RE and RE. Postexercise mTORC1 signaling following RE is therefore not compromised by prior HIT or MICT, and concurrent exercise incorporating HIT, but not MICT, reduces postexercise expression of miRNAs implicated in skeletal muscle adaptation to RE.

  18. The Krüppel traffic report: Cooperative signals direct KLF8 nuclear transport

    Institute of Scientific and Technical Information of China (English)

    Estefanía Rodríguez; John A Martignetti

    2009-01-01

    @@ The Krüppel-like transcription fac-tor (KLF) family consists of 17 dis-tinct family members involved in the regulation of diverse cellular processes including differentiation, cell prolifera-tion, growth-related signal transduction, angiogenesis and apoptosis (recently reviewed in [1]). In addition to their currently known biologic roles, the discovery that at least one member of the family, KLF6, can be alternatively spliced into biologically active isoforms with antagonistic functions and a dis-tinct subcellular localization pattern [2], highlights the fact that nuclear-cytoplasmic shuttling of KLF proteins may represent an additional layer of functional regulation and the possibility of an even more diverse and completely unexplored role for KLF family mem-bers in both health and disease.

  19. TGF-β Signaling Regulates Pancreatic β-Cell Proliferation through Control of Cell Cycle Regulator p27 Expression

    International Nuclear Information System (INIS)

    Proliferation of pancreatic β-cells is an important mechanism underlying β-cell mass adaptation to metabolic demands. Increasing β-cell mass by regeneration may ameliorate or correct both type 1 and type 2 diabetes, which both result from inadequate production of insulin by β-cells of the pancreatic islet. Transforming growth factor β (TGF-β) signaling is essential for fetal development and growth of pancreatic islets. In this study, we exposed HIT-T15, a clonal pancreatic β-cell line, to TGF-β signaling. We found that inhibition of TGF-β signaling promotes proliferation of the cells significantly, while TGF-β signaling stimulation inhibits proliferation of the cells remarkably. We confirmed that this proliferative regulation by TGF-β signaling is due to the changed expression of the cell cycle regulator p27. Furthermore, we demonstrated that there is no observed effect on transcriptional activity of p27 by TGF-β signaling. Our data show that TGF-β signaling mediates the cell-cycle progression of pancreatic β-cells by regulating the nuclear localization of CDK inhibitor, p27. Inhibition of TGF-β signaling reduces the nuclear accumulation of p27, and as a result this inhibition promotes proliferation of β-cells

  20. Life Cycle Cost Analysis of City Rail Traffic Vehicle%城市轨道交通车辆全寿命周期成本分析

    Institute of Scientific and Technical Information of China (English)

    蒋钧杰; 谈飞

    2014-01-01

    City rail transportation has become an important part of modern city traffic system, and are being integrated into each big city of our country gradually. The vehicle is the core of city rail traffic engineering part. At present, in city track traffic vehicle procurement tender selection, only consider the vehicle purchase price, not include the life cycle cost of the vehicle, so the decision is only local optimum, not the best overall. The article analyzes the city rail transit vehicle life cycle stages, and breakdown the city track traffic vehicle life cycle cost, on this basis, article establishs the city track traffic vehicle life cycle cost model. At last, the city rail transit vehicle life cycle cost model is applied to an example. The conclusion is:vehicle purchase costs account for only 51. 68% in the vehicle life cycle cost, so the city track traffic vehicle selection should base on the whole life cycle cost.%城市轨道交通已经成为现代城市交通体系的重要组成部分,并且正在逐渐融入我国的各个大中城市。车辆是城市轨道交通工程中的核心组成部分。目前城市轨道交通车辆采购招标比选时,仅仅考虑车辆采购价格,并不包括车辆全寿命周期各个阶段发生的成本,因此做出的决策只是局部最优,并不是整体最佳。论文对城市轨道交通车辆全寿命周期的阶段进行划分,并对城市轨道交通车辆全寿命周期成本进行了成本分解,在此基础上构建了城市轨道交通车辆全寿命周期成本模型。最后将城市轨道交通车辆全寿命周期成本模型应用于地铁A型车辆进行实例分析,得出结论为:车辆购置成本占车辆全寿命周期成本的51.68%,所以进行城市轨道交通车辆选型时应从车辆的全寿命周期出发。

  1. Traffic-generated changes in the chemical characteristics of size-segregated urban aerosols.

    Science.gov (United States)

    Rogula-Kozłowska, Wioletta

    2014-10-01

    The road traffic impact on the concentrations of 13 fractions of particulate matter (PM) and their components was assessed. PM was sampled at two points in Katowice (southern Poland), a background point beyond the effects of road traffic, and a near-highway traffic point. The samples were analyzed for organic and elemental carbon, 8 water-soluble ions, 24 elements, and 16 polycyclic aromatic hydrocarbons (PAHs). The traffic emissions (mainly particles from car exhaust) enriched the ultrafine, submicron, and fine PM particles with elemental carbon. The traffic-caused re-suspension of the road and soil dust affecting the concentrations and chemical composition of the coarse PM fraction. However, for each PM fraction, the carcinogenic equivalent ratios, assumed as a measure of the hazard from 16 PAHs in this paper, were similar at the two sampling points. The traffic emissions from the highway appeared to have a weaker influence on the concentrations and chemical composition of PM in a typical urban area of southern Poland than elsewhere in Europe.

  2. Glucose Signaling-Mediated Coordination of Cell Growth and Cell Cycle in Saccharomyces Cerevisiae

    Directory of Open Access Journals (Sweden)

    Stefano Busti

    2010-06-01

    Full Text Available Besides being the favorite carbon and energy source for the budding yeast Sacchromyces cerevisiae, glucose can act as a signaling molecule to regulate multiple aspects of yeast physiology. Yeast cells have evolved several mechanisms for monitoring the level of glucose in their habitat and respond quickly to frequent changes in the sugar availability in the environment: the cAMP/PKA pathways (with its two branches comprising Ras and the Gpr1/Gpa2 module, the Rgt2/Snf3-Rgt1 pathway and the main repression pathway involving the kinase Snf1. The cAMP/PKA pathway plays the prominent role in responding to changes in glucose availability and initiating the signaling processes that promote cell growth and division. Snf1 (the yeast homologous to mammalian AMP-activated protein kinase is primarily required for the adaptation of yeast cell to glucose limitation and for growth on alternative carbon source, but it is also involved in the cellular response to various environmental stresses. The Rgt2/Snf3-Rgt1 pathway regulates the expression of genes required for glucose uptake. Many interconnections exist between the diverse glucose sensing systems, which enables yeast cells to fine tune cell growth, cell cycle and their coordination in response to nutritional changes.

  3. Plasticity in the vocalizations of anurans in response to traffic noise

    Science.gov (United States)

    Cunnington, Glenn M.; Fahrig, Lenore

    2010-09-01

    Many species use acoustic signals to attract mates, and such signals can be degraded by anthropogenic noise. Anuran abundance has been shown to be negatively correlated with road traffic which could be due in part to the interruption of mate attraction by traffic noise. However, this impact could be small if anurans can alter their vocalization characteristics to avoid masking of their calls by traffic noise. We predicted that: (i) anuran vocalization characteristics (dominant frequency, mean amplitude and call rate) should be different in areas with different traffic noise levels; (ii) increases in traffic noise can cause immediate changes in amphibian vocalization characteristics; (iii) these altered vocalizations are similar to those at high traffic sites. To test the first prediction we compared vocalizations of four species of anuran at breeding sites in locations with low traffic noise vs. sites with high traffic noise. For the second prediction we broadcast traffic noise at low traffic (quiet) sites, and compared the anuran vocalizations before vs. during the broadcast traffic noise. For the third prediction we compared vocalizations at high traffic sites to those produced at low traffic sites while broadcasting traffic noise. Three species of anurans found at locations with low traffic noise produced vocalizations with different characteristics than individuals of the same species found in locations with high traffic noise. Broadcast traffic noise immediately altered amphibian vocalization characteristics such that they became similar to those of the same species found in locations with high traffic noise. We conclude that plasticity in the vocalizations of anurans allows for the maintenance of acoustic communication in the presence of traffic noise.

  4. Development of a computer-aided diagnostic scheme for detection of interval changes in successive whole-body bone scans

    International Nuclear Information System (INIS)

    Bone scintigraphy is the most frequent examination among various diagnostic nuclear medicine procedures. It is a well-established imaging modality for the diagnosis of osseous metastasis and for monitoring osseous tumor response to chemotherapy and radiation therapy. Although the sensitivity of bone scan examinations for detection of bone abnormalities has been considered to be relatively high, it is time consuming to identify multiple lesions such as bone metastases of prostate and breast cancers. In addition, it is very difficult to detect subtle interval changes between two successive abnormal bone scans, because of variations in patient conditions, the accumulation of radioisotopes during each examination, and the image quality of gamma cameras. Therefore, we developed a new computer-aided diagnostic (CAD) scheme for the detection of interval changes in successive whole-body bone scans by use of a temporal subtraction image which was obtained with a nonlinear image-warping technique. We carried out 58 pairs of successive bone scans in which each scan included both posterior and anterior views. We determined 107 'gold-standard' interval changes among the 58 pairs based on the consensus of three radiologists. Our computerized scheme consisted of seven steps, i.e., initial image density normalization on each image, image matching for the paired images, temporal subtraction by use of the nonlinear image-warping technique, initial detection of interval changes by use of temporal-subtraction images, image feature extraction of candidates of interval changes, rule-based tests by use of 16 image features for removing some false positives, and display of the computer output for identified interval changes. One hundred seven gold standard interval changes included 71 hot lesions (uptake was increased compared with the previous scan, or there was new uptake in the current scan) and 36 cold lesions (uptake was decreased or disappeared) for anterior and posterior views. The

  5. Revealing a quantum feature of dimensionless uncertainty in linear and quadratic potentials by changing potential intervals

    Science.gov (United States)

    Kheiri, R.

    2016-09-01

    As an undergraduate exercise, in an article (2012 Am. J. Phys. 80 780–14), quantum and classical uncertainties for dimensionless variables of position and momentum were evaluated in three potentials: infinite well, bouncing ball, and harmonic oscillator. While original quantum uncertainty products depend on {{\\hslash }} and the number of states (n), a dimensionless approach makes the comparison between quantum uncertainty and classical dispersion possible by excluding {{\\hslash }}. But the question is whether the uncertainty still remains dependent on quantum number n. In the above-mentioned article, there lies this contrast; on the one hand, the dimensionless quantum uncertainty of the potential box approaches classical dispersion only in the limit of large quantum numbers (n\\to ∞ )—consistent with the correspondence principle. On the other hand, similar evaluations for bouncing ball and harmonic oscillator potentials are equal to their classical counterparts independent of n. This equality may hide the quantum feature of low energy levels. In the current study, we change the potential intervals in order to make them symmetric for the linear potential and non-symmetric for the quadratic potential. As a result, it is shown in this paper that the dimensionless quantum uncertainty of these potentials in the new potential intervals is expressed in terms of quantum number n. In other words, the uncertainty requires the correspondence principle in order to approach the classical limit. Therefore, it can be concluded that the dimensionless analysis, as a useful pedagogical method, does not take away the quantum feature of the n-dependence of quantum uncertainty in general. Moreover, our numerical calculations include the higher powers of the position for the potentials.

  6. The recent dramatic decline in road mortality in France: how drivers' attitudes towards road traffic safety changed between 2001 and 2004 in the GAZEL cohort. : Driver‘s attitudinal changes toward traffic safety

    OpenAIRE

    Constant, Aymery; Salmi, Louis Rachid; Lafont, Sylviane; Chiron, Mireille; Lagarde, Emmanuel

    2008-01-01

    International audience; A very significant decline in the number of road casualties has been observed recently in France, concomitantly with a dramatic increase in law enforcement. The aim of this study was (i) to assess changes in attitudes about road traffic accident (RTA) prevention initiatives in France from 2001 to 2004 and (ii) to identify factors associated with an increase in positive attitudes towards RTA prevention initiatives. In 2001 and 2004, 9216 participants reported their atti...

  7. INTRODUCTION: Anticipated changes in the global atmospheric water cycle

    Science.gov (United States)

    Allan, Richard P.; Liepert, Beate G.

    2010-06-01

    The atmospheric branch of the water cycle, although containing just a tiny fraction of the Earth's total water reserves, presents a crucial interface between the physical climate (such as large-scale rainfall patterns) and the ecosystems upon which human societies ultimately depend. Because of the central importance of water in the Earth system, the question of how the water cycle is changing, and how it may alter in future as a result of anthropogenic changes, present one of the greatest challenges of this century. The recent Intergovernmental Panel on Climate Change report on Climate Change and Water (Bates et al 2008) highlighted the increasingly strong evidence of change in the global water cycle and associated environmental consequences. It is of critical importance to climate prediction and adaptation strategies that key processes in the atmospheric water cycle are precisely understood and determined, from evaporation at the surface of the ocean, transport by the atmosphere, condensation as cloud and eventual precipitation, and run-off through rivers following interaction with the land surface, sub-surface, ice, snow and vegetation. The purpose of this special focus issue of Environmental Research Letters on anticipated changes in the global atmospheric water cycle is to consolidate the recent substantial advances in understanding past, present and future changes in the global water cycle through evidence built upon theoretical understanding, backed up by observations and borne out by climate model simulations. Thermodynamic rises in water vapour provide a central constraint, as discussed in a guest editorial by Bengtsson (2010). Theoretical implications of the Clausius-Clapeyron equation are presented by O'Gorman and Muller (2010) and with reference to a simple model (Sherwood 2010) while observed humidity changes confirm these anticipated responses at the land and ocean surface (Willett et al 2008). Rises in low-level moisture are thought to fuel an

  8. The burden of road traffic accidents in a French Departement: the description of the injuries and recent changes

    Directory of Open Access Journals (Sweden)

    Chiron Mireille

    2009-10-01

    Full Text Available Abstract Background A significant reduction in road traffic accidents has been observed since prevention measures were introduced by the French public authorities in 2002. The goals of this study are to describe the burden of road traffic accidents in a French Departement, and to identify changes if any between the periods 1997-2001 and 2002-2006 on the basis of the disability adjusted life years (DALY. Methods Years of lost life (YLL and years lived with disability (YLD were calculated for two periods using the mortality and incidence data in the Rhone Departement Registry of Road Traffic Accident Casualties. Results YLD and YLL that are related to road traffic accidents are at their maximum value between 15 and 24 years of age. For men, intracranial fractures and intracranial injuries dominate, and for women it is spinal cord injuries that account for highest rates of YLD. A reduction in the rates of YLL and YLD has been observed for both genders and all age groups between 1997-2001 and 2002-2006. Conclusion The reduction in DALY between the two periods is explained both by the reduction in the number of fatalities and injuries but also by an increase in the age at which they occur.

  9. Estimation of Early Postmortem Interval Through Biochemical and Pathological Changes in Rat Heart and Kidney.

    Science.gov (United States)

    Abo El-Noor, Mona Mohamed; Elhosary, Naema Mahmoud; Khedr, Naglaa Fathi; El-Desouky, Kareema Ibraheem

    2016-03-01

    Accurate estimation of time passed since death is a complicated task in forensic medicine especially in homicide or unwitnessed death investigations. Changes in oxidant/antioxidant parameters were investigated if it can be relied upon in estimating the early postmortem interval (EPI) in rat heart and kidney, and whether these changes were correlated with histopathological findings in these tissues. Heart and kidney tissues of 84 male albino rats were divided into 2 parts. One part used for estimation of levels of malondialdehyde (MDA), nitric oxide (NO), and total thiol as well as the activity of glutathione reductase (GR), glutathione S transferase, and catalase. The second part was examined histopathologically. It was found that MDA and NO were significantly increased earlier in the heart than kidney tissues. Meanwhile, total thiol, catalase, glutathione S transferase, and GR were commenced to be significantly decreased in the heart before kidney tissues. Linear regression analysis of independent variables of heart was found to be of a high predictive value of 97.2% (EPI = 8.607 - 0.240 GR + 0.002 MDA + 0.014 NO). Structural deterioration of heart started 3 to 4 hours compared with renal sections that began 5 to 6 hours after death. The relationship between oxidant and antioxidant parameters is crucial in determining the EPI. The kidney was found to be more resistible to oxidative damage. Further research on humans is needed.

  10. Influences of driver’s attributions on signalized intersection traffic%驾驶员属性对信号灯路口交通流的影响研究

    Institute of Scientific and Technical Information of China (English)

    梅超群

    2014-01-01

    A cellular automaton model is proposed to study the traffic at signalized intersection. The driving behaviors induced by driver’s attribution (gender, driving experience, character, etc. ) are numerically analyzed. Simulation results show that the rusty driving skills or tension driving, impatient driving and so on can lead to the transition from free flow to congestion more easily, and these behaviors are the important cause for low travel efficiency at the intersection; the signal cycle is the main factor influencing traffic flux and travel time fairness.%采用元胞自动机模型研究信号灯路口的交通流特性,系统地分析了与性别、驾驶经验、性格等驾驶员属性相关的驾驶行为对交通流的影响。数值模拟发现,技术生疏或紧张驾驶、急躁行驶等驾驶行为更易引发自由流到阻塞流的相变,是路口通行低效率及事故隐患的重要原因,信号周期是影响流量与个人通行时间公平的主要因素。

  11. Change in physiological signals during mindfulness meditation

    OpenAIRE

    Ahani, Asieh; Wahbeh, Helane; Miller, Meghan; Nezamfar, Hooman; Erdogmus, Deniz; Oken, Barry

    2013-01-01

    Mindfulness meditation (MM) is an inward mental practice, in which a resting but alert state of mind is maintained. MM intervention was performed for a population of older people with high stress levels. This study assessed signal processing methodologies of electroencephalographic (EEG) and respiration signals during meditation and control condition to aid in quantification of the meditative state. EEG and respiration data were collected and analyzed on 34 novice meditators after a 6-week me...

  12. Handwriting and speech changes across the levodopa cycle in Parkinson's disease.

    Science.gov (United States)

    Poluha, P C; Teulings, H L; Brookshire, R H

    1998-11-01

    Levodopa treatment is used to reduce rigidity and bradykinesia in Parkinson's disease (PD). This study tracked the handwriting and speech performance of 10 PD patients at 30-minute intervals across one levodopa drug cycle to evaluate levodopa-related changes in temporal and spatial measures that are assumed to correspond to changes in rigidity and bradykinesia. The handwriting measures included l and e upstroke duration and size. The speech measures included duration of the vowels /i/, /u/, /ae/, and /[symbol: see text]/ and the quadrilateral area produced by these vowels, and the slope of the diphthong /aI/. Levodopa significantly improved handwriting upstroke duration but not upstroke size. Speech measures did not show a significant trend across the levodopa cycle. The results suggest that upstroke duration is sensitive to the presumed effects of levodopa and that handwriting analysis may hold promise in helping to estimate an optimum levodopa regimen for PD patients. PMID:9844557

  13. Acute High-Intensity Interval Exercise-Induced Redox Signaling Is Associated with Enhanced Insulin Sensitivity in Obese Middle-Aged Men

    Science.gov (United States)

    Parker, Lewan; Stepto, Nigel K.; Shaw, Christopher S.; Serpiello, Fabio R.; Anderson, Mitchell; Hare, David L.; Levinger, Itamar

    2016-01-01

    Background: Obesity and aging are associated with increased oxidative stress, activation of stress and mitogen activated protein kinases (SAPK), and the development of insulin resistance and metabolic disease. In contrast, acute exercise also increases oxidative stress and SAPK signaling, yet is reported to enhance insulin sensitivity and reduce the risk of metabolic disease. This study explored this paradox by investigating the effect of a single session of high-intensity interval-exercise (HIIE) on redox status, muscle SAPK and insulin protein signaling in eleven middle-aged obese men. Methods: Participants completed a 2 h hyperinsulinaemic-euglycaemic clamp at rest, and 60 min after HIIE (4 × 4 mins at 95% HRpeak; 2 min recovery periods), separated by 1–3 weeks. Results: Irrespective of exercise-induced changes to redox status, insulin stimulation both at rest and after HIIE similarly increased plasma superoxide dismutase activity, plasma catalase activity, and skeletal muscle 4-HNE; and significantly decreased plasma TBARS and hydrogen peroxide. The SAPK signaling pathways of p38 MAPK, NF-κB p65, and JNK, and the distal insulin signaling protein AS160Ser588, were activated with insulin stimulation at rest and to a greater extent with insulin stimulation after a prior bout of HIIE. Higher insulin sensitivity after HIIE was associated with higher insulin-stimulated SOD activity, JNK, p38 MAPK and NF-κB phosphorylation (r = 0.63, r = 0.71, r = 0.72, r = 0.71; p < 0.05, respectively). Conclusion:These findings support a role for redox homeostasis and SAPK signaling in insulin-stimulated glucose uptake which may contribute to the enhancement of insulin sensitivity in obese men 3 h after HIIE.

  14. Modelling the Traffic System

    Directory of Open Access Journals (Sweden)

    Važan Pavel

    2014-12-01

    Full Text Available The paper presents the simulation study results of the traffic system in the city of Hlohovec. The authors describe the process of building the model in Witness 2013c simulator. The individual entities of simulation model are explained in details, as the Witness simulator is primarily suitable for manufacture or service simulation and not for traffic system simulation. The goal of this paper is to analyse the traffic system and to suggest the changes for improving the traffic in the city of Hlohovec. All proposed measures will bring about 20% improvement of traffic when compared to the current state.

  15. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

    OpenAIRE

    Peeper, D.S.; Upton, T.M.; Ladha, M H; Neuman, E; Zalvide, J; Bernards, R.A.; DeCaprio, J A; Ewen, M E

    1997-01-01

    The Ras proto-oncogene is a central component of mitogenic signal-transduction pathways, and is essential for cells both to leave a quiescent state (GO) and to pass through the GI/S transition of the cell cycle. The mechanism by which Ras signalling regulates cell-cycle progression is unclear, however. Here we report that the retinoblastoma tumour-suppressor protein (Rb), a regulator of GI exit, functionally links Ras to passage through the Gl phase. Inactivation of Ras in cycling cells cause...

  16. Mixed traffic flow model considering illegal lane-changing behavior: Simulations in the framework of Kerner’s three-phase theory

    Science.gov (United States)

    Hu, Xiaojian; Wang, Wei; Yang, Haifei

    2012-11-01

    This paper studies the mixed motorized vehicle (m-vehicle) and non-motorized vehicle (nm-vehicle) traffic flow in the m-vehicle lane. We study the formation mechanism of the nm-vehicle illegal lane-changing behavior (NILB) by considering the overtaking motivation and the traffic safety awareness. In the framework of Kerner’s three-phase theory, we propose a model for the mixed traffic flow by introducing a new set of rules. A series of simulations are carried out in order to reveal the formation, travel process and influence of the mixed traffic flow. The simulation results show that the proposed model can be used to study not only the travel characteristic of the mixed traffic flow, but also some complex traffic problems such as traffic breakdown, moving synchronized flow pattern (MSP) and moving jam. Moreover, the results illustrate that the proposed model reflects the phenomenon of the mixed flow and the influence of the MSP caused by the NILB, which is consistent with the actual traffic system, and thus this work is helpful for the management of the mixed traffic flow.

  17. A Review of "Life Cycle: How We Grow and Change"

    Science.gov (United States)

    Digioia, Melissa Keyes

    2010-01-01

    Sexuality education curricula designed for youths with special needs are sparse. "Life Cycle: How We Grow and Change" (Vavricheck & Tolle, 2008) is a new curriculum by clinical social workers Sherrie Mansfield Vavricheck and R. Kay Tolle. Each chapter addresses a particular developmental stage between birth and death. Lessons within each chapter…

  18. Hedgehog signaling acts with the temporal cascade to promote neuroblast cell cycle exit.

    Directory of Open Access Journals (Sweden)

    Phing Chian Chai

    Full Text Available In Drosophila postembryonic neuroblasts, transition in gene expression programs of a cascade of transcription factors (also known as the temporal series acts together with the asymmetric division machinery to generate diverse neurons with distinct identities and regulate the end of neuroblast proliferation. However, the underlying mechanism of how this "temporal series" acts during development remains unclear. Here, we show that Hh signaling in the postembryonic brain is temporally regulated; excess (earlier onset of Hh signaling causes premature neuroblast cell cycle exit and under-proliferation, whereas loss of Hh signaling causes delayed cell cycle exit and excess proliferation. Moreover, the Hh pathway functions downstream of Castor but upstream of Grainyhead, two components of the temporal series, to schedule neuroblast cell cycle exit. Interestingly, hh is likely a target of Castor. Hence, Hh signaling provides a link between the temporal series and the asymmetric division machinery in scheduling the end of neurogenesis.

  19. Sequential changes of fresh and fixed specimen on MRI : optimal time interval and fixatives for good correlation with in Vivo State

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Sung Kyu; Lim, Myung Kwan; Cho, Soon Gu; Yoh, Kyu Tong; Suh, Chang Hae [Inha University, Incheon (Korea, Republic of). Coll. of Medicine

    1998-01-01

    With the development of MR imaging techniques, MRI and MR spectroscopy can be used to evaluate specimens both in vivo and in vitro. For extracted tissue specimens we wished to obtain MR images with correlated well with image obtained in vive: the purpose of this study was to determine which fixatives and time interval best facilitated this objective. ON T1WI, signal intensities of both tissue specimens fixed in formalin and ethanol and untreated specimens increased significantly during the first 30 minutes. The increased signal intensity then seen for 12 hours was greater than on T2WI, signal intensities of tissue specimens fixed in formalin and ethanol and untreated specimens showed no significant changes within the first 30 minutes: after that, they showed less signal intensity change for 12 hours than on T1WI. To obtain MR images with the same signal intensities as in vivo tissue, MRI of tissue specimens in the untreated state should be performed as soon as possible after resection. On T2WI, signal intensities of tissue specimens were more similar to in vivo tissue than on T1WI. (author). 13 refs., 10 figs.

  20. Change in spontaneous baroreflex control of pulse interval during heat stress in humans.

    Science.gov (United States)

    Lee, Kichang; Jackson, Dwayne N; Cordero, Douglas L; Nishiyasu, Takeshi; Peters, Jochen K; Mack, Gary W

    2003-11-01

    Spontaneous baroreflex control of pulse interval (PI) was assessed in healthy volunteers under thermoneutral and heat stress conditions. Subjects rested in the supine position with their lower legs in a water bath at 34 degrees C. Heat stress was imposed by increasing the bath temperature to 44 degrees C. Arterial blood pressure (Finapres), PI (ECG), esophageal and skin temperature, and stroke volume were continuously collected during each 5-min experimental stage. Spontaneous baroreflex function was evaluated by multiple techniques, including 1) the mean slope of the linear relationship between PI and systolic blood pressure (SBP) with three or more simultaneous increasing or decreasing sequences, 2) the linear relationship between changes in PI and SBP (deltaPI/DeltaSBP) derived by using the first differential equation, 3) the linear relationship between changes in PI and SBP with simultaneously increasing or decreasing sequences (+deltaPI/+deltaSBP or -deltaPI/-deltaSBP), and 4) transfer function analysis. Heat stress increased esophageal temperature by 0.6 +/- 0.1 degrees C, decreased PI from 1,007 +/- 43 to 776 +/- 37 ms and stroke volume by 16 +/- 5 ml/beat. Heat stress reduced baroreflex sensitivity but increased the incidence of baroreflex slopes from 5.2 +/- 0.8 to 8.6 +/- 0.9 sequences per 100 heartbeats. Baroreflex sensitivity was significantly correlated with PI or vagal power (r2 = 0.45, r2 = 0.71, respectively; P heat stress appeared related to a shift in autonomic balance (shift in resting PI) rather than heat stress per se. PMID:12882987

  1. Changes in gene expression and signal transduction in microgravity

    Science.gov (United States)

    Hughes-Fulford, M.

    2001-01-01

    Studies from space flights over the past three decades have demonstrated that basic physiological changes occur in humans during space flight. These changes include cephalic fluid shifts, loss of fluid and electrolytes, loss of muscle mass, space motion sickness, anemia, reduced immune response, and loss of calcium and mineralized bone. The cause of most of these manifestations is not known and until recently, the general approach was to investigate general systemic changes, not basic cellular responses to microgravity. This laboratory has recently studied gene growth and activation of normal osteoblasts (MC3T3-El) during spaceflight. Osteoblast cells were grown on glass coverslips and loaded in the Biorack plunger boxes. The osteoblasts were launched in a serum deprived state, activated in microgravity and collected in microgravity. The osteoblasts were examined for changes in gene expression and signal transduction. Approximately one day after growth activation significant changes were observed in gene expression in 0-G flight samples. Immediate early growth genes/growth factors cox-2, c-myc, bcl2, TGF beta1, bFGF and PCNA showed a significant diminished mRNA induction in microgravity FCS activated cells when compared to ground and 1-G flight controls. Cox-1 was not detected in any of the samples. There were no significant differences in the expression of reference gene mRNA between the ground, 0-G and 1-G samples. The data suggest that quiescent osteoblasts are slower to enter the cell cycle in microgravity and that the lack of gravity itself may be a significant factor in bone loss in spaceflight. Preliminary data from our STS 76 flight experiment support our hypothesis that a basic biological response occurs at the tissue, cellular, and molecular level in 0-G. Here we examine ground-based and space flown data to help us understand the mechanism of bone loss in microgravity.

  2. Changed vegetation composition in coniferous forests near to motorways in Southern Germany: The effects of traffic-born pollution

    International Nuclear Information System (INIS)

    To estimate the effect of traffic emissions on the vegetation composition of coniferous forests near to motorways, three transects of 520 m length were studied by analysing vegetation composition, soil parameters and deposition data in the Munich-area, Southern Germany. The detected patterns suggest that motorways have an impact on the vegetation composition in the neighbourhood of roads. Depending on the wind direction, the influences of the motorways reaches up to 230 m on downwind side and up to 80 m on upwind side. The vegetation is mainly affected by the deposition of nitrogen deriving from fuel combustion and by basic substances added to road salt. By monitoring vegetation changes near to motorways, it is possible to estimate the areas where harmful alterations of the ecosystem can be expected. - Vegetation near motorways was strongly influenced by traffic-borne nitrogen

  3. The Effect of Drive Signal Limiting on High Cycle Fatigue Life Analysis

    Science.gov (United States)

    Kihm, Frederic; Rizzi, Stephen A.

    2014-01-01

    It is common practice to assume a Gaussian distribution of both the input acceleration and the response when modeling random vibration tests. In the laboratory, however, shaker controllers often limit the drive signal to prevent high amplitude peaks. The high amplitudes may either be truncated at a given level (socalled brick wall limiting or abrupt clipping), or compressed (soft limiting), resulting in drive signals which are no longer Gaussian. The paper first introduces several methods for limiting a drive signal, including brick wall limiting and compression. The limited signal is then passed through a linear time-invariant system representing a device under test. High cycle fatigue life predictions are subsequently made using spectral fatigue and rainflow cycle counting schemes. The life predictions are compared with those obtained from unclipped input signals. Some guidelines are provided to help the test engineer decide how clipping should be applied under different test scenarios.

  4. Modeling and remote sensing of human induced water cycle change

    Science.gov (United States)

    Pokhrel, Yadu N.

    2016-04-01

    The global water cycle has been profoundly affected by human land-water management especially during the last century. Since the changes in water cycle can affect the functioning of a wide range of biophysical and biogeochemical processes of the Earth system, it is essential to account for human land-water management in land surface models (LSMs) which are used for water resources assessment and to simulate the land surface hydrologic processes within Earth system models (ESMs). During the last two decades, noteworthy progress has been made in modeling human impacts on the water cycle but sufficient advancements have not yet been made, especially in representing human factors in large-scale LSMs toward integrating them into ESMs. In this study, an integrated modeling framework of continental-scale water cycle, with explicit representation of climate and human induced forces (e.g., irrigation, groundwater pumping) is developed and used to reconstruct the observed water cycle changes in the past and to attribute the observed changes to climatic and human factors. The new model builds upon two different previously developed models: a global LSM called the Human Impacts and GroundWater in the MATSIRO (HiGW-MAT) and a high-resolution regional groundwater model called the LEAF-Hydro-Flood. The model is used to retro-simulate the hydrologic stores and fluxes in close dialogue with in-situ and GRACE satellite based observations at a wide range of river basin scales around the world, with a particular focus on the changes in groundwater dynamics in northwest India, Pakistan, and the High Plains and Central Valley aquifers in the US.

  5. Calcium Signaling throughout the Toxoplasma gondii Lytic Cycle: A STUDY USING GENETICALLY ENCODED CALCIUM INDICATORS.

    Science.gov (United States)

    Borges-Pereira, Lucas; Budu, Alexandre; McKnight, Ciara A; Moore, Christina A; Vella, Stephen A; Hortua Triana, Miryam A; Liu, Jing; Garcia, Celia R S; Pace, Douglas A; Moreno, Silvia N J

    2015-11-01

    Toxoplasma gondii is an obligate intracellular parasite that invades host cells, creating a parasitophorous vacuole where it communicates with the host cell cytosol through the parasitophorous vacuole membrane. The lytic cycle of the parasite starts with its exit from the host cell followed by gliding motility, conoid extrusion, attachment, and invasion of another host cell. Here, we report that Ca(2+) oscillations occur in the cytosol of the parasite during egress, gliding, and invasion, which are critical steps of the lytic cycle. Extracellular Ca(2+) enhances each one of these processes. We used tachyzoite clonal lines expressing genetically encoded calcium indicators combined with host cells expressing transiently expressed calcium indicators of different colors, and we measured Ca(2+) changes in both parasites and host simultaneously during egress. We demonstrated a link between cytosolic Ca(2+) oscillations in the host and in the parasite. Our approach also allowed us to measure two new features of motile parasites, which were enhanced by Ca(2+) influx. This is the first study showing, in real time, Ca(2+) signals preceding egress and their direct link with motility, an essential virulence trait.

  6. T cell traffic signals

    OpenAIRE

    Van Epps, Heather L.

    2005-01-01

    In 1990, Charles Mackay and colleagues combined classical physiology with modern molecular biology to provide the first concrete evidence that naive and memory T cells follow distinct migratory routes out of the bloodstream— a discovery that helped invigorate the field of lymphocyte homing.

  7. Two-layer hierarchical control solutions for traffic signal%面向交通信号的两层递阶控制解决方案

    Institute of Scientific and Technical Information of China (English)

    戈军; 周莲英

    2015-01-01

    针对现有交通信号控制系统的诸多不足,提出了一种用于交通信号控制的两层递阶多Agent系统解决方案。通过将交通网络进行区域划分,利用底层Agent控制各交叉口,顶层Agent控制区域,从而实现两层递阶控制。底层Agent采用经典Q学习同步学习最优策略,顶层Agent利用Tile Coding非凡的连续空间处理能力,实现Q学习的动作值函数逼近方法。仿真实验结果表明,该分层递阶控制不但提高了交通信号控制系统效率,而且也为大规模应用提供了很好的可伸缩解决方案。%In view of the existing deficiencies of traffic signal control system, this paper proposes two-layer hierarchical multi-Agent system solution for traffic signal control. Through regional division of the traffic network, it uses the bottom level Agent to control the intersection, the top level Agent to control areas, so as to achieve the two-layer hierarchical con-trol. The bottom level Agent uses the classical Q-learning to synchronize the optimal strategy, the top level Agent utilizes the special continuous space processing ability of Tile Coding to achieve Q learning of action value function approxima-tion method. The simulation test results show that, the hierarchical control not only improves the efficiency of traffic signal control system, but also provides a good scalable solution for large-scale applications.

  8. Simulation Study of a Traffic Light Assistant Based on Vehicle-Infrastructure Communication

    CERN Document Server

    Treiber, Martin

    2014-01-01

    Vehicle-infrastructure communication opens up new ways to improve traffic flow efficiency at signalized intersections. In this study, we assume that equipped vehicles can obtain information about switching times of relevant traffic lights in advance, and additionally counting data from upstream detectors. By means of simulation, we investigate, how equipped vehicles can make use of this information to improve traffic flow. Criteria include cycle-averaged capacity, driving comfort, fuel consumption, travel time, and the number of stops. Depending on the overall traffic demand and the penetration rate of equipped vehicles, we generally find several percent of improvement.

  9. Projected changes in the annual wind-wave cycle

    Science.gov (United States)

    Stopa, Justin; Hemer, Mark

    2016-04-01

    The uneven distribution of the sun's energy directly and indirectly drives physical atmosphere and ocean processes. This creates intricate spatial patterns within the seasonal cycle where higher order harmonics are seen to play an important role in regional climates. The annual cycle and associated harmonics are the strongest oscillations within the climate system and describe the majority of variance across the oceans. Consequently when studying climate oscillations, it is common practice to remove the seasonal cycle in order to elucidate inter-annual cycles. Furthermore the annual cycle plays an important role in the evolution of other inter-annual oscillations through non-linear coupling (e.g ENSO). Despite the important role of the seasons within the climate system very few studies describe the seasonality with any rigor. Therefore our focus is to describe the higher harmonics linked to the annual cycle and how they are expected to evolve in a changing climate. Using simulations from the Coordinated Ocean Wave Climate Project, the seasonality of multiple mid and end of the 21st century wind-wave climate projections are analyzed relative to historical experiment forced simulations. A comparison of various GCM forced wave simulations to reanalysis datasets reveals that a multi-model ensemble best describes the seasons. This ensemble is used to describe the changes within the wave seasonality. A systematic analysis reveals the primary mode of the seasons is relatively unchanged in the mid and end century. The largest changes occur in the second and third modes. The second mode defines the shift or translation within the seasons while the third mode characterizes relative change between the seasonal extremes (ie sharpening or flattening of the waveform). The relative changes in the second and third modes are not homogeneous and intricate patterns are revealed. Certain regions have sharper contrast in seasonality while other regions have a longer strong season. In

  10. Trace Analysis of Driver Behavior on Traffic Violator by Using Big Data (Traffic Program in Korea

    Directory of Open Access Journals (Sweden)

    Lee, Jonghak

    2016-01-01

    Full Text Available This study aims to prove the effectiveness of traffic safety education program for traffic violators. Traffic violators who finished the traffic safety education programs were tracked down. In order to analyze the effectiveness of traffic safety education program, traffic violator’s data during ten-year period were used. This study analyzed how traffic violators changed their attitudes about traffic law abidance. Also predicted social benefits from traffic safety education program for traffic violators. Effectiveness of traffic accident prevention through traffic safety education program is approximately 93%. In terms of social benefits, it shows more than $12 billion Even though the effectiveness of traffic safety education program represents remarkable results, but this program is made for traffic violators who have already committed traffic offenses in the past. So in order to prevent traffic violations in advance, specific education program for potentially risky drivers is necessary.

  11. [Level of and change in road traffic mortality in Argentina, Chile, Colombia and Mexico, 2000-2011].

    Science.gov (United States)

    Escanés, Gabriel; Agudelo-Botero, Marcela; Cardona, Doris

    2015-09-01

    The aim of this study was to estimate the effect of run-over fatalities and traffic collisions in life expectancy in Argentina, Chile, Colombia and Mexico, between 2000 and 2011. Years of life expectancy lost (YLEL) were calculated for the periods 2000-2002 and 2009-2011. The results show that road traffic deaths made up between 1% and 4% of all deaths in each country. In the first period, the highest level of mortality occurred in Colombia (YLEL=0.96) and the lowest in Argentina (YLEL=0.59). In all the countries studied except Argentina, the impact of these deaths on life expectancy was reduced in the second period. The main change took place in Colombia, reaching 0.72 YLEL in the second period. It is concluded that traffic-related deaths have a negative impact on health systems, victims, the productive sector, and society in general. From this point of view, the issue of road transit must be considered a matter of public health, requiring multi-sector intervention in the design of national and regional policies.

  12. Studies on Urban Traffic Capacity Change under the Influence of Traffic Accident%交通事故影响下事发路段通行能力变化研究

    Institute of Scientific and Technical Information of China (English)

    程望斌; 罗艳; 张浩; 尹丽; 袁媛; 雷新平; 贺利苗

    2013-01-01

    With the development of social economy and the speeding up of urbanization, transport problems have became increasingly prominent, urban road traffic capacity is influenced by many factors, but the most significant is traffic accident .To study the road capacity ,two typical traffic accidents as the example are used in this paper. Combining with the actual situation of road traffic accident, setting up the model of traffic wave theory, using MATLAB software to analyze and process traffic data, we received the actual capacity changes line and curve fitting during an accident in cross section. Through contrastive analysis, two kind of typical reasons of traffic changes are gotten, and traffic capacity changes are elaborated and evaluated scientifically. So the research methods and results in this paper are scientific, and also provides an important reference basis for urban road traffic management.%随着社会经济的发展和城市化进程的加快,城市交通问题日益严重,城市道路通行能力受诸多因素影响,其中交通事故影响最为显著。本文以两起典型交通事故为例,对事发路段通行能力进行研究。结合交通事故中的实际情况,建立交通波理论模型,用 MATLAB 软件对交通数据进行分析和处理,得到事故所处横断面实际通行能力变化的折线和拟合曲线图。通过对比分析,得到两种典型事故中实际通行能力的变化情况,并对通行能力变化原因进行了详细阐述和科学评价。因此,文中的研究方法和结果具有一定的科学性,为城市道路交通管理提供了重要的参考依据。

  13. COMPARATIVE EVALUATION OF QTC INTERVAL CHANGES WITH INTRAVENOUS ONDANSETRON AND PALONOSETRON IN PATIENTS UNDERGOING LAPROSCOPIC CHOLECYSTECTOMY

    Directory of Open Access Journals (Sweden)

    Anju

    2015-06-01

    Full Text Available Post - operative nausea and vomiting (PONV is a common and distressing symptom after surgery performed under general anesthesia. 5HT 3 antagonists are routinely used for PONV but are dreaded to cause QTc interval prolongation. The aim of our study was to compare the incidence of QTc interval prolongation and quantify the amount of QTc prolongation from the baseline value with IV ondansetron and Palonosetron when given for PONV prevention. 60 patients undergoing elective laproscopic surgery for cholelithiasis were randomly divided into 2 groups of 30 patients each and received 4mg of Ondansetron and 0.075mg of Palonosetron intravenously respectively before induction of anesthesia. Intraoperatively serial ECG was recorded at various intervals 0min, 3min, 15min, 1hr and 2hrs along with other routine monitoring and QTc was calculated in secs by Bazett Formula. RESULTS: The QTc interval was prolonged in Ondansetron group at all - time intervals as compared to Palonosetron group where prolongation was observed only at 3 min though this difference was statistically insignificant (P>0.05 . The difference between Ondansetron and Palonosetron group was comparable.

  14. Complex response of the forest nitrogen cycle to climate change.

    Science.gov (United States)

    Bernal, Susana; Hedin, Lars O; Likens, Gene E; Gerber, Stefan; Buso, Don C

    2012-02-28

    Climate exerts a powerful influence on biological processes, but the effects of climate change on ecosystem nutrient flux and cycling are poorly resolved. Although rare, long-term records offer a unique opportunity to disentangle effects of climate from other anthropogenic influences. Here, we examine the longest and most complete record of watershed nutrient and climate dynamics available worldwide, which was collected at the Hubbard Brook Experimental Forest in the northeastern United States. We used empirical analyses and model calculations to distinguish between effects of climate change and past perturbations on the forest nitrogen (N) cycle. We find that climate alone cannot explain the occurrence of a dramatic >90% drop in watershed nitrate export over the past 46 y, despite longer growing seasons and higher soil temperatures. The strongest climate influence was an increase in soil temperature accompanied by a shift in paths of soil water flow within the watershed, but this effect explained, at best, only ∼40% of the nitrate decline. In contrast, at least 50-60% of the observed change in the N export could be explained by the long-lasting effect of forest cutting in the early 1900s on the N cycle of the soil and vegetation pools. Our analysis shows that historic events can obscure the influence of modern day stresses on the N cycle, even when analyses have the advantage of being informed by 0.5-century-long datasets. These findings raise fundamental questions about interpretations of long-term trends as a baseline for understanding how climate change influences complex ecosystems. PMID:22331889

  15. Complex response of the forest nitrogen cycle to climate change

    OpenAIRE

    Bernal, Susana; Hedin, L. O.; Likens, G. E.; Gerber, S; D. Buso

    2012-01-01

    Climate exerts a powerful influence on biological processes, but the effects of climate change on ecosystem nutrient flux and cycling are poorly resolved. Although rare, long-term records offer a unique opportunity to disentangle effects of climate from other anthropogenic influences. Here, we examine the longest and most complete record of watershed nutrient and climate dynamics available worldwide, which was collected at the Hubbard Brook Experimental Forest in the northeastern United State...

  16. Laser signals' nonlinear change in fatty acids

    CERN Document Server

    Ghelmez-Dumitru, M; Piscureanu, M; Sterian, A

    2003-01-01

    Previous works showed that thin layers of fatty acids and fatty acid-cholesterol mixtures behaved as optical liquid crystals, even at low incident laser power. The paper presents an experimental and computer study of laser signals, emergent from such samples, in presence of fluctuations. The optical emergent laser beams' features at different incident parameters were experimentally determined for different type (c.w. and pulsed) lasers, as for example helium-neon and Nd sup 3 sup + glass lasers. The results were correlated with the amount of cholesterol in mixtures and with their response in external electric field. These measurements are in all cases affected by fluctuations. We developed some computer-based procedures, by using the TableCurve3D from Jandel Scientific software and equations Runge-Kutta in MATLAB for taking into account these fluctuations.

  17. Commercial aircraft noise modeling Effects of air traffic and airport infrastructure changes

    OpenAIRE

    Khardi, S.; Konovalova, E.; LADEGAILLERIE, Y; HAMADICHE, M

    2010-01-01

    International air traffic is growing rapidly and environmental concerns induced by excessive aircraft noise become a major objective of airport authorities and aircraft manufacturers despite of the reduction of the aircraft noise levels by 20 dB during the last thirty years. The large numbers of people living in communities near airports, affected by aircraft noise, have been complaining. This paper gives detailed operations data of Lyon Saint-Exupéry International Airport (France) and provid...

  18. Impacts of Traffic Noise and Traffic Volume on Birds of Roadside Habitats

    Directory of Open Access Journals (Sweden)

    Angela Schneider

    2009-06-01

    Full Text Available Roadside habitats are important for a range of taxa including plants, insects, mammals, and birds, particularly in developed countries in which large expanses of native vegetation have been cleared for agriculture or urban development. Although roadside vegetation may provide suitable habitat for many species, resident animals can be exposed to high levels of traffic noise, visual disturbance from passing vehicles, and the risk of collision with cars and trucks. Traffic noise can reduce the distance over which acoustic signals such as song can be detected, an effect known as acoustic interference or masking. Studies from the northern hemisphere show that the singing behavior of birds changes in the presence of traffic noise. We investigated the impact of traffic noise and traffic volume on two species of birds, the Grey Shrike-thrush (Colluricincla harmonica and the Grey Fantail (Rhipidura fuliginosa, at 58 roadside sites on the Mornington Peninsula, southeastern Australia. The lower singing Grey Shrike-thrush sang at a higher frequency in the presence of traffic noise, with a predicted increase in dominant frequency of 5.8 Hz/dB of traffic noise, and a total effect size of 209 Hz. In contrast, the higher singing Grey Fantail did not appear to change its song in traffic noise. The probability of detecting each species on a visit to a site declined substantially with increasing traffic noise and traffic volume, with several lines of evidence supporting a larger effect of traffic noise. Traffic noise could hamper detection of song by conspecifics, making it more difficult for birds to establish and maintain territories, attract mates and maintain pair bonds, and possibly leading to reduced breeding success in noisy roadside habitats. Closing key roads during the breeding season is a potential, but untested, management strategy to protect threatened bird species from traffic noise and collision with vehicles at the time of year when they are most

  19. Cell cycle arrest by a gradient of Dpp signaling during Drosophila eye development

    Directory of Open Access Journals (Sweden)

    Bhattacharya Abhishek

    2010-03-01

    Full Text Available Abstract Background The secreted morphogen Dpp plays important roles in spatial regulation of gene expression and cell cycle progression in the developing Drosophila eye. Dpp signaling is required for timely cell cycle arrest ahead of the morphogenetic furrow as a prelude to differentiation, and is also important for eye disc growth. The dpp gene is expressed at multiple locations in the eye imaginal disc, including the morphogenetic furrow that sweeps across the eye disc as differentiation initiates. Results Studies of Brinker and Dad expression, and of Mad phosphorylation, establish that there is a gradient of Dpp signaling in the eye imaginal disc anterior to the morphogenetic furrow, predominantly in the anterior-posterior axis, and also Dpp signaling at the margins of the disc epithelium and in the dorsal peripodial membrane. Almost all signaling activity seems to spread through the plane of the epithelia, although peripodial epithelium cells can also respond to underlying disc cells. There is a graded requirement for Dpp signaling components for G1 arrest in the eye disc, with more stringent requirements further anteriorly where signaling is lower. The signaling level defines the cell cycle response, because elevated signaling through expression of an activated Thickveins receptor molecule arrested cells at more anterior locations. Very anterior regions of the eye disc were not arrested in response to activated receptor, however, and evidence is presented that expression of the Homothorax protein may contribute to this protection. By contrast to activated Thickveins, ectopic expression of processed Dpp leads to very high levels of Mad phosphorylation which appear to have non-physiological consequences. Conclusions G1 arrest occurs at a threshold level of Dpp signaling within a morphogen gradient in the anterior eye. G1 arrest is specific for one competent domain in the eye disc, allowing Dpp signaling to promote growth at earlier

  20. How can we understand the solar cycle signal on the Earth's surface?

    OpenAIRE

    Kodera, Kunihiko; Thieblemont, Remi; Yukimoto, Seiji; Matthes, Katja

    2016-01-01

    To understand solar cycle signals on the Earth's surface and identify the physical mechanisms responsible, surface temperature variations from observations as well as climate model data are analyzed to characterize their spatial structure. The solar signal in the annual mean surface temperature is characterized by (i) mid-latitude warming and (ii) no warming in the tropics. The mid-latitude warming during solar maxima in both hemispheres is associated with a downward penetration of zonal mean...

  1. Gene expression profiling in true interval breast cancer reveals overactivation of the mTOR signaling pathway

    NARCIS (Netherlands)

    Rojo, F.; Domingo, L.; Sala, M.; Zazo, S.; Chamizo, C.; Menendez, S.; Arpi, O.; Corominas, J.; Bragado, R.; Servitja, S.; Tusquets, I.; Nonell, L.; Macia, F.; Martinez, J.; Rovira, A.; Albanell, J.; Castells, X.

    2014-01-01

    BACKGROUND: The development and progression of true interval breast cancers (tumors that truly appear after a negative screening mammogram) is known to be different from screen-detected cancers. However, the worse clinical behavior of true interval cancers is not fully understood from a biologic bas

  2. Sensibility to Changes of Vibrational Modes of Excited Electron: Sum Frequency Signals Versus Difference Frequency Signals*

    Institute of Scientific and Technical Information of China (English)

    GU An-Na; LIANG Xian-Ting

    2011-01-01

    In this paper, we investigate a two electronic level system with vibrational modes coupled to a Brownian oscillator bath. The difference frequency generation (DFG) signals and sum frequency generation (SFG) signals are calculated. It is shown that, for the same model, the SFG signals are more sensitive than the DFG signals to the changes of the vibrational modes of the electronic two-level system. Because the SFG conversion efficiency can be improved by using the time-delay method, the findings in this paper predict that the SFG spectrum may probe the changes of the microstructure more effectively.

  3. Change in Water Cycle- Important Issue on Climate Earth System

    Science.gov (United States)

    Singh, Pratik

    Change in Water Cycle- Important Issue on Climate Earth System PRATIK KUMAR SINGH1 1BALDEVRAM MIRDHA INSTITUTE OF TECHNOLOGY,JAIPUR (RAJASTHAN) ,INDIA Water is everywhere on Earth and is the only known substance that can naturally exist as a gas, liquid, and solid within the relatively small range of air temperatures and pressures found at the Earth's surface.Changes in the hydrological cycle as a consequence of climate and land use drivers are expected to play a central role in governing a vast range of environmental impacts.Earth's climate will undergo changes in response to natural variability, including solar variability, and to increasing concentrations of green house gases and aerosols.Further more, agreement is widespread that these changes may profoundly affect atmospheric water vapor concentrations, clouds and precipitation patterns.As we know that ,a warmer climate, directly leading to increased evaporation, may well accelerate the hydrological cycle, resulting in an increase in the amount of moisture circulating through the atmosphere.The Changing Water Cycle programmer will develop an integrated, quantitative understanding of the changes taking place in the global water cycle, involving all components of the earth system, improving predictions for the next few decades of regional precipitation, evapotranspiration, soil moisture, hydrological storage and fluxes.The hydrological cycle involves evaporation, transpiration, condensation, precipitation, and runoff. NASA's Aqua satellite will monitor many aspects of the role of water in the Earth's systems, and will do so at spatial and temporal scales appropriate to foster a more detailed understanding of each of the processes that contribute to the hydrological cycle. These data and the analyses of them will nurture the development and refinement of hydrological process models and a corresponding improvement in regional and global climate models, with a direct anticipated benefit of more accurate weather and

  4. Changes In QTc Interval Duration Among Heroin Addicts On Methadone Treatment

    Directory of Open Access Journals (Sweden)

    Jovanovic Mirjana

    2015-09-01

    Full Text Available This paper aimed to collect and unite facts known about the effect of methadone treatment on QTc interval prolongation that could determine precipitating factors in the development of heart arrhythmias and their consequences (Torsade de Pointes and sudden cardiac death, and to raise the methadone treatment safety level.

  5. Reference Intervals, Intraindividual and Interindividual Variability, and Reference Change Values for Hematologic Variables in Laboratory Beagles

    OpenAIRE

    Bourgès-Abella, Nathalie H; Gury, Thierry D; Geffré, Anne; Concordet, Didier; Thibault-Duprey, Kevin C; Dauchy, Arnaud; Trumel, Catherine

    2015-01-01

    In research and development studies for human and veterinary medicine, relevant comparators for interpreting clinical pathology results are matched with concurrent control animals. However, reference intervals (RI) provide a comparator database and important aids for interpreting clinical pathology data, especially in laboratory beagle dogs. Furthermore, RI incorporate biologic variation, which includes analytical, intraindividual, and interindividual variation. No studies to date have establ...

  6. The effect of esmolol on corrected-QT interval, corrected-QT interval dispersion changes seen during anesthesia induction in hypertensive patients taking an angiotensin-converting enzyme inhibitor

    OpenAIRE

    Zahit Çeker; Suna Akin Takmaz; Bülent Baltaci; Hülya Basar

    2015-01-01

    BACKGROUND AND OBJECTIVES: The importance of minimizing the exaggerated sympatho-adrenergic responses and QT interval and QT interval dispersion changes that may develop due to laryngoscopy and tracheal intubation during anesthesia induction in the hypertensive patients is clear. Esmolol decreases the hemodynamic response to laryngoscopy and intubation. However, the effect of esmolol in decreasing the prol...

  7. High intensity interval and moderate continuous cycle training in a physical education programme improves health-related fitness in young females.

    Science.gov (United States)

    Mazurek, K; Zmijewski, P; Krawczyk, K; Czajkowska, A; Kęska, A; Kapuściński, P; Mazurek, T

    2016-06-01

    The aim of the study was to investigate the effects of eight weeks of regular physical education classes supplemented with high intensity interval cycle exercise (HIIE) or continuous cycle exercises of moderate intensity (CME). Forty-eight collegiate females exercising in two regular physical education classes per week were randomly assigned to two programmes (HIIE; n = 24 or CME; n = 24) of additional (one session of 63 minutes per week) physical activity for 8 weeks. Participants performed HIIE comprising 2 series of 6x10 s sprinting with maximal pedalling cadence and active recovery pedalling with intensity 65%-75% HRmax or performed CME corresponding to 65%-75% HRmax. Before and after the 8-week programmes, anthropometric data and aero- and anaerobic capacity were measured. Two-way ANOVA revealed a significant time main effect for VO2max (p < 0.001), similar improvements being found in both groups (+12% in HIIE and +11% in CME), despite body mass not changing significantly (p = 0.59; +0.4% in HIIE and -0.1% in CME). A significant main time effect was found for relative fat mass (FM) and fat-free mass (FFM) (p < 0.001 and p < 0.001, respectively). A group x time interaction effect was found for relative FM and FFM (p = 0.018 and p = 0.018); a greater reduction in FM and greater increase in FFM were noted in the CME than the HIIE group. Improvements in anaerobic power were observed in both groups (p < 0.001), but it was greater in the HIIE group (interaction effect, p = 0.022). Weight loss is not mandatory for exercise-induced effects on improving aerobic and anaerobic capacity in collegiate females. Eight weeks of regular physical education classes supplemented with CME sessions are more effective in improving body composition than physical education classes supplemented with HIIE sessions. In contrast to earlier, smaller trials, similar improvements in aerobic capacity were observed following physical activity with additional HIIE or CME sessions. PMID:27274106

  8. Study on the effects of driver's lane-changing aggressiveness on traffic stability from an extended two-lane lattice model

    Science.gov (United States)

    Li, Zhipeng; Zhang, Run; Xu, Shangzhi; Qian, Yeqing

    2015-07-01

    In this paper, the effects of driver's lane-changing aggressiveness on the stability of traffic flow of two-lane are studied by using a generalized lattice hydrodynamic model with consideration of lane-changing aggressiveness of each individual. The effect of lane-changing aggressiveness parameter on traffic stability is derived through employing linear stability analysis with finding that the driver's lane-changing aggressiveness has an important impact on the stability of the traffic flow in a two-lane system. To describe the phase transition, the mKdV equation near the critical point is derived by using the reductive perturbation method, with obtaining the dependence of the propagation kink solution for traffic jams on the lane-changing aggressiveness. It can be concluded from the phase diagram of stability criterion that the higher lane-changing aggressiveness leads to a more stable traffic flow. In addition, the stabilizing effect of the optimal current difference weakens gradually with the increasing of the lane-changing aggressiveness adjusting coefficient, even vanishes when the value of lane-changing aggressiveness adjusting coefficient is greater than a critical value. Theoretical conclusions are also confirmed by the numerical simulations.

  9. Using co-operative vehicle-infrastructure systems to reduce traffic emissions and improve air quality at signalized urban intersections

    NARCIS (Netherlands)

    Mahmod, Mohamed Kamil Morsi

    2011-01-01

    Road transport has expanded the scope of human mobility, increasing the distances people travel. However, the recent increase in the number of vehicles has resulted in many adverse consequences in terms of safety, efficiency and the environment. Traffic emissions are known to be the main source of a

  10. Optimizing urban traffic control using a rational agent

    Institute of Scientific and Technical Information of China (English)

    Salvador IBARRA-MARTÍNEZ; José A. CASTÁN-ROCHA; Julio LARIA-MENCHACA

    2014-01-01

    This paper is devoted to developing and evaluating a set of technologies with the objective of designing a method-ology for the implementation of sophisticated traffic lights by means of rational agents. These devices would be capable of op-timizing the behavior of a junction with multiple traffic signals, reaching a higher level of autonomy without losing reliability, accuracy, or efficiency in the offered services. In particular, each rational agent in a traffic signal will be able to analyze the requirements and constraints of the road, in order to know its level of demand. With such information, the rational agent will adapt its light cycles with the view of accomplishing more fluid traffic patterns and minimizing the pollutant environmental emissions produced by vehicles while they are stopped at a red light, through using a case-based reasoning (CBR) adaptation. This paper also integrates a microscopic simulator developed to run a set of tests in order to compare the presented methodology with traditional traffic control methods. Two study cases are shown to demonstrate the efficiency of the introduced approach, increasing vehicular mobility and reducing harmful activity for the environment. For instance, in the first scenario, taking into account the studied traffic volumes, our approach increases mobility by 23%and reduces emissions by 35%. When the roads are managed by sophisticated traffic lights, a better level of service and considerable environmental benefits are achieved, demon-strating the utility of the presented approach.

  11. Innovation cycle for small- and large-scale change.

    Science.gov (United States)

    Scott, Kathy; Steinbinder, Amy

    2009-01-01

    In today's complex healthcare systems, transformation requires 2 major efforts: (1) a fundamental changes in the underlying beliefs and assumptions that perpetuate the current system and (2) a fundamental redesign of the multiplicity of diverse and complex subsystems that result in unpredictable aggregate behavior and outcomes. Through an Intelligent Complex Adaptive System framework combined with an innovation process a transformation process and cycle was created for a large healthcare system that resulted in both small- and large-scale changes. This process not only challenges the underlying beliefs and assumptions but also creates new possibilities and prototypes for care delivery through a change-management process that is inclusive and honors the contributions of the entire team.

  12. Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus.

    Directory of Open Access Journals (Sweden)

    Franco Folli

    Full Text Available Insulin resistance, reduced β-cell mass, and hyperglucagonemia are consistent features in type 2 diabetes mellitus (T2DM. We used pancreas and islets from humans with T2DM to examine the regulation of insulin signaling and cell-cycle control of islet cells. We observed reduced β-cell mass and increased α-cell mass in the Type 2 diabetic pancreas. Confocal microscopy, real-time PCR and western blotting analyses revealed increased expression of PCNA and down-regulation of p27-Kip1 and altered expression of insulin receptors, insulin receptor substrate-2 and phosphorylated BAD. To investigate the mechanisms underlying these findings, we examined a mouse model of insulin resistance in β-cells--which also exhibits reduced β-cell mass, the β-cell-specific insulin receptor knockout (βIRKO. Freshly isolated islets and β-cell lines derived from βIRKO mice exhibited poor cell-cycle progression, nuclear restriction of FoxO1 and reduced expression of cell-cycle proteins favoring growth arrest. Re-expression of insulin receptors in βIRKO β-cells reversed the defects and promoted cell cycle progression and proliferation implying a role for insulin-signaling in β-cell growth. These data provide evidence that human β- and α-cells can enter the cell-cycle, but proliferation of β-cells in T2DM fails due to G1-to-S phase arrest secondary to defective insulin signaling. Activation of insulin signaling, FoxO1 and proteins in β-cell-cycle progression are attractive therapeutic targets to enhance β-cell regeneration in the treatment of T2DM.

  13. Spatiotemporal traffic-flow dependency and short-term traffic forecasting

    OpenAIRE

    Yang Yue; Anthony Gar-On Yeh

    2008-01-01

    Short-term traffic forecasting is playing an increasing role in modern transport management. Although many short-term traffic forecasting methods have been explored, the spatiotemporal dependency of traffic flow, an important characteristic of traffic dynamics that can benefit the forecasting of traffic changes, is often neglected in short-term traffic forecasting. This paper first investigates the spatiotemporal dependency of traffic flow using cross-correlation analysis and then discusses i...

  14. Traffic engineering eye diagram

    OpenAIRE

    Kowalik, Karol; Collier, Martin

    2005-01-01

    It is said that a picture is worth a thousand words - this statement also applies to networking topics. Thus, to effectively monitor network performance we need tools which present the performance metrics in a graphical way which is also clear and informative. We propose a tool for this purpose which we call the traffic engineering eye diagram (TEED). Eye diagrams are used in digital communications to analyse the quality of a digital signal; the TEED can similarly he used in the traffic engin...

  15. Abiotic and biogeochemical signals derived from the seasonal cycles of tropospheric nitrous oxide

    Directory of Open Access Journals (Sweden)

    C. D. Nevison

    2010-11-01

    Full Text Available Seasonal cycles in the mixing ratios of tropospheric nitrous oxide (N2O are derived by detrending long-term measurements made at sites across four global surface monitoring networks. These cycles are examined for physical and biogeochemical signals. The detrended monthly data display large interannual variability, which at some sites challenges the concept of a "mean" seasonal cycle. The interannual variability in the seasonal cycle is not always correlated among networks that share common sites. In the Northern Hemisphere, correlations between detrended N2O seasonal minima and polar winter lower stratospheric temperature provide compelling evidence for a stratospheric influence, which varies in strength from year to year and can explain much of the interannual variability in the surface seasonal cycle. Even at sites where a strong, competing, regional N2O source exists, such as from coastal upwelling at Trinidad Head, California, the stratospheric influence must be understood in order to interpret the biogeochemical signal in monthly mean data. In the Southern Hemisphere, detrended surface N2O monthly means are correlated with polar lower stratospheric temperature in months preceding the N2O minimum, suggesting a coherent stratospheric influence in that hemisphere as well. A decomposition of the N2O seasonal cycle in the extratropical Southern Hemisphere suggests that ventilation of deep ocean water (microbially enriched in N2O and the stratospheric influx make similar contributions in phasing, and may be difficult to disentangle. In addition, there is a thermal signal in N2O due to seasonal ingassing and outgassing of cooling and warming surface waters that is out of phase and thus competes with the stratospheric and ventilation signals. All the seasonal signals discussed above are subtle and are generally better quantified in high-frequency in situ data

  16. An experimental evaluation of electrical skin conductivity changes in postmortem interval and its assessment for time of death estimation.

    Science.gov (United States)

    Cantürk, İsmail; Karabiber, Fethullah; Çelik, Safa; Şahin, M Feyzi; Yağmur, Fatih; Kara, Sadık

    2016-02-01

    In forensic medicine, estimation of the time of death (ToD) is one of the most important and challenging medico-legal problems. Despite the partial accomplishments in ToD estimations to date, the error margin of ToD estimation is still too large. In this study, electrical conductivity changes were experimentally investigated in the postmortem interval in human cases. Electrical conductivity measurements give some promising clues about the postmortem interval. A living human has a natural electrical conductivity; in the postmortem interval, intracellular fluids gradually leak out of cells. These leaked fluids combine with extra-cellular fluids in tissues and since both fluids are electrolytic, intracellular fluids help increase conductivity. Thus, the level of electrical conductivity is expected to increase with increased time after death. In this study, electrical conductivity tests were applied for six hours. The electrical conductivity of the cases exponentially increased during the tested time period, indicating a positive relationship between electrical conductivity and the postmortem interval.

  17. Branched signal wiring of an essential bacterial cell-cycle phosphotransfer protein

    OpenAIRE

    Blair, Jimmy A.; Xu, Qingping; Childers, W. Seth; Mathews, Irimpan I.; Kern, Justin W.; Eckart, Michael; Deacon, Ashley M.; Shapiro, Lucy

    2013-01-01

    Vital to bacterial survival is the faithful propagation of cellular signals, and in Caulobacter crescentus ChpT is an essential mediator within the cell cycle circuit. ChpT functions as a histidine-containing phosphotransfer protein (HPt) that shuttles a phosphoryl group from the receiver domain of CckA, the upstream hybrid histidine kinase (HK), to one of two downstream response regulators (RRs)—CtrA or CpdR—that controls cell cycle progression. To understand how ChpT interacts with multiple...

  18. 蛋白激酶C信号通路在温石棉致肺成纤维 细胞的细胞周期和凋亡改变中的作用%The role of protein kinase C signal transduction pathways in the changes of both cell cycle and apoptosis of human embryonic pulmonary fibrob last induced by chrysotile

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective To explore the relationship betwe en protein kinase C(PKC) signal transduction pathway and the changes of both cel l cycle and apoptosis of human embryonic pulmonary fibroblast(HEPF) induced by chrysotile. Methods Flow cytometry to measure changes of both cell c ycle and apoptosis of HEPF induced by the supernatants of chrysotile-treated ra bbit alveolar macrophage(AM) was used,and different controls:blank control,norma l control(AM),negative (TiO2) and positive(SiO2) control were set up. Results  In the process of proliferation of HEPF stimulated by the supernata nt of AM treated by chrysotile,the percentage of the cells of G2/M phase of HE PF in chrysotile group was 7.2%,higher than that in all controls;and the apoptos is percentage was 3.5%,significantly lower than that in all controls(P <0.01).PKC inhibitor(C25H24N4O2) made the percentage of cells of S phase decreased from 37.8% to 27.3%(P<0.01) and apoptosis perc entage increased from 3.5% to 22.7%(P<0.01),but PKC activator(PMA) made the percentage of S phase cells increased. Conclusion Th e change of cell cycle in HEPF proliferation induced by chrysotile was related t o the up-stream PKC signal pathway. The role of PKC activator or inhibitor was realized by p rimarily regulating DNA synthesis during S phase and inducing apoptosis of cell.%目的 探讨蛋白激酶C(PKC)信号通路 与温 石棉致人胚肺成纤维细胞(HEPF)的细胞周期及细胞凋亡改变的联系。方法 利用流式细胞技术测定PKC的抑制剂或激活剂对温石棉处理兔肺泡巨噬细胞(AM)的培 养上清液致HEPF的细胞周期和凋亡改变的影响。同时设立空白对照、正常对照(不加粉尘的A M)、阴性对照(标准TiO2)和阳性对照(标准SiO2)。结果 温石 棉处理AM的上清液刺激HEPF增殖时,HEPF的G2/M期细胞百分比为7.2%,高于各对照组,而 细胞凋亡百分率为3.5%,低于各对照组,差异均有显著性(P<0.01);PKC抑制剂C 25 H24N4O

  19. Modelling component evaporation and composition change of traffic-induced ultrafine particles during travel from street canyon to urban background.

    Science.gov (United States)

    Nikolova, Irina; MacKenzie, A Rob; Cai, Xiaoming; Alam, Mohammed S; Harrison, Roy M

    2016-07-18

    We developed a model (CiTTy-Street-UFP) of traffic-related particle behaviour in a street canyon and in the nearby downwind urban background that accounts for aerosol dynamics and the variable vapour pressure of component organics. The model simulates the evolution and fate of traffic generated multicomponent ultrafine particles (UFP) composed of a non-volatile core and 17 Semi-Volatile Organic Compounds (SVOC, modelled as n-alkane proxies). A two-stage modelling approach is adopted: (1) a steady state simulation inside the street canyon is achieved, in which there exists a balance between traffic emissions, condensation/evaporation, deposition, coagulation and exchange with the air above roof-level; and (2) a continuing simulation of the above-roof air parcel advected to the nearby urban park during which evaporation is dominant. We evaluate the component evaporation and associated composition changes of multicomponent organic particles in realistic atmospheric conditions and compare our results with observations from London (UK) in a street canyon and an urban park. With plausible input conditions and parameter settings, the model can reproduce, with reasonable fidelity, size distributions in central London in 2007. The modelled nucleation-mode peak diameter, which is 23 nm in the steady-state street canyon, decreases to 9 nm in a travel time of just 120 s. All modelled SVOC in the sub-10 nm particle size range have evaporated leaving behind only non-volatile material, whereas modelled particle composition in the Aitken mode contains SVOC between C26H54 and C32H66. No data on particle composition are available in the study used for validation, or elsewhere. Measurements addressing in detail the size resolved composition of the traffic emitted UFP in the atmosphere are a high priority for future research. Such data would improve the representation of these particles in dispersion models and provide the data essential for model validation. Enhanced knowledge of the

  20. Modelling component evaporation and composition change of traffic-induced ultrafine particles during travel from street canyon to urban background.

    Science.gov (United States)

    Nikolova, Irina; MacKenzie, A Rob; Cai, Xiaoming; Alam, Mohammed S; Harrison, Roy M

    2016-07-18

    We developed a model (CiTTy-Street-UFP) of traffic-related particle behaviour in a street canyon and in the nearby downwind urban background that accounts for aerosol dynamics and the variable vapour pressure of component organics. The model simulates the evolution and fate of traffic generated multicomponent ultrafine particles (UFP) composed of a non-volatile core and 17 Semi-Volatile Organic Compounds (SVOC, modelled as n-alkane proxies). A two-stage modelling approach is adopted: (1) a steady state simulation inside the street canyon is achieved, in which there exists a balance between traffic emissions, condensation/evaporation, deposition, coagulation and exchange with the air above roof-level; and (2) a continuing simulation of the above-roof air parcel advected to the nearby urban park during which evaporation is dominant. We evaluate the component evaporation and associated composition changes of multicomponent organic particles in realistic atmospheric conditions and compare our results with observations from London (UK) in a street canyon and an urban park. With plausible input conditions and parameter settings, the model can reproduce, with reasonable fidelity, size distributions in central London in 2007. The modelled nucleation-mode peak diameter, which is 23 nm in the steady-state street canyon, decreases to 9 nm in a travel time of just 120 s. All modelled SVOC in the sub-10 nm particle size range have evaporated leaving behind only non-volatile material, whereas modelled particle composition in the Aitken mode contains SVOC between C26H54 and C32H66. No data on particle composition are available in the study used for validation, or elsewhere. Measurements addressing in detail the size resolved composition of the traffic emitted UFP in the atmosphere are a high priority for future research. Such data would improve the representation of these particles in dispersion models and provide the data essential for model validation. Enhanced knowledge of the

  1. Notch signaling regulates late-stage epidermal differentiation and maintains postnatal hair cycle homeostasis.

    Directory of Open Access Journals (Sweden)

    Hsien-Yi Lin

    Full Text Available BACKGROUND: Notch signaling involves ligand-receptor interactions through direct cell-cell contact. Multiple Notch receptors and ligands are expressed in the epidermis and hair follicles during embryonic development and the adult stage. Although Notch signaling plays an important role in regulating differentiation of the epidermis and hair follicles, it remains unclear how Notch signaling participates in late-stage epidermal differentiation and postnatal hair cycle homeostasis. METHODOLOGY AND PRINCIPAL FINDINGS: We applied Cre/loxP system to generate conditional gene targeted mice that allow inactivation of critical components of Notch signaling pathway in the skin. Rbpj, the core component of all four Notch receptors, and Pofut1, an essential factor for ligand-receptor interactions, were inactivated in hair follicle lineages and suprabasal layer of the epidermis using the Tgfb3-Cre mouse line. Rbpj conditional inactivation resulted in granular parakeratosis and reactive epidermal hyperplasia. Pofut1 conditional inactivation led to ultrastructural abnormalities in the granular layer and altered filaggrin processing in the epidermis, suggesting a perturbation of the granular layer differentiation. Disruption of Pofut1 in hair follicle lineages resulted in aberrant telogen morphology, a decrease of bulge stem cell markers, and a concomitant increase of K14-positive keratinocytes in the isthmus of mutant hair follicles. Pofut1-deficent hair follicles displayed a delay in anagen re-entry and dysregulation of proliferation and apoptosis during the hair cycle transition. Moreover, increased DNA double stand breaks were detected in Pofut1-deficent hair follicles, and real time PCR analyses on bulge keratinocytes isolated by FACS revealed an induction of DNA damage response and a paucity of DNA repair machinery in mutant bulge keratinocytes. SIGNIFICANCE: our data reveal a role for Notch signaling in regulating late-stage epidermal differentiation

  2. Note on Studying Change Point of LRD Traffic Based on Li's Detection of DDoS Flood Attacking

    Directory of Open Access Journals (Sweden)

    Zhengmin Xia

    2010-01-01

    Full Text Available Distributed denial-of-service (DDoS flood attacks remain great threats to the Internet. To ensure network usability and reliability, accurate detection of these attacks is critical. Based on Li's work on DDoS flood attack detection, we propose a DDoS detection method by monitoring the Hurst variation of long-range dependant traffic. Specifically, we use an autoregressive system to estimate the Hurst parameter of normal traffic. If the actual Hurst parameter varies significantly from the estimation, we assume that DDoS attack happens. Meanwhile, we propose two methods to determine the change point of Hurst parameter that indicates the occurrence of DDoS attacks. The detection rate associated with one method and false alarm rate for the other method are also derived. The test results on DARPA intrusion detection evaluation data show that the proposed approaches can achieve better detection performance than some well-known self-similarity-based detection methods.

  3. Signal detection using change point analysis in postmarket surveillance†

    OpenAIRE

    Xu, Zhiheng; Kass-Hout, Taha; Anderson-Smits, Colin; Gray, Gerry

    2015-01-01

    Purpose Signal detection methods have been used extensively in postmarket surveillance to identify elevated risks of adverse events associated with medical products (drugs, vaccines, and devices). However, current popular disproportionality methods ignore useful information such as trends when the data are aggregated over time for signal detection. Methods In this paper, we applied change point analysis (CPA) to trend analysis of medical products in a spontaneous adverse event reporting syste...

  4. Are signalized intersections with cycle tracks safer? A case-control study based on automated surrogate safety analysis using video data.

    Science.gov (United States)

    Zangenehpour, Sohail; Strauss, Jillian; Miranda-Moreno, Luis F; Saunier, Nicolas

    2016-01-01

    Cities in North America have been building bicycle infrastructure, in particular cycle tracks, with the intention of promoting urban cycling and improving cyclist safety. These facilities have been built and expanded but very little research has been done to investigate the safety impacts of cycle tracks, in particular at intersections, where cyclists interact with turning motor-vehicles. Some safety research has looked at injury data and most have reached the conclusion that cycle tracks have positive effects of cyclist safety. The objective of this work is to investigate the safety effects of cycle tracks at signalized intersections using a case-control study. For this purpose, a video-based method is proposed for analyzing the post-encroachment time as a surrogate measure of the severity of the interactions between cyclists and turning vehicles travelling in the same direction. Using the city of Montreal as the case study, a sample of intersections with and without cycle tracks on the right and left sides of the road were carefully selected accounting for intersection geometry and traffic volumes. More than 90h of video were collected from 23 intersections and processed to obtain cyclist and motor-vehicle trajectories and interactions. After cyclist and motor-vehicle interactions were defined, ordered logit models with random effects were developed to evaluate the safety effects of cycle tracks at intersections. Based on the extracted data from the recorded videos, it was found that intersection approaches with cycle tracks on the right are safer than intersection approaches with no cycle track. However, intersections with cycle tracks on the left compared to no cycle tracks seem to be significantly safer. Results also identify that the likelihood of a cyclist being involved in a dangerous interaction increases with increasing turning vehicle flow and decreases as the size of the cyclist group arriving at the intersection increases. The results highlight the

  5. Clustering in Cell Cycle Dynamics with General Response/Signaling Feedback

    CERN Document Server

    Young, Todd; Buckalew, Richard; Moses, Gregory; Boczko, Erik; 10.1016/j.jtbi.2011.10.002.

    2011-01-01

    Motivated by experimental and theoretical work on autonomous oscillations in yeast, we analyze ordinary differential equations models of large populations of cells with cell-cycle dependent feedback. We assume a particular type of feedback that we call Responsive/Signaling (RS), but do not specify a functional form of the feedback. We study the dynamics and emergent behaviour of solutions, particularly temporal clustering and stability of clustered solutions. We establish the existence of certain periodic clustered solutions as well as "uniform" solutions and add to the evidence that cell-cycle dependent feedback robustly leads to cell-cycle clustering. We highlight the fundamental differences in dynamics between systems with negative and positive feedback. For positive feedback systems the most important mechanism seems to be the stability of individual isolated clusters. On the other hand we find that in negative feedback systems, clusters must interact with each other to reinforce coherence. We conclude fr...

  6. Climate Change Impairs Nitrogen Cycling in European Beech Forests.

    Science.gov (United States)

    Dannenmann, Michael; Bimüller, Carolin; Gschwendtner, Silvia; Leberecht, Martin; Tejedor, Javier; Bilela, Silvija; Gasche, Rainer; Hanewinkel, Marc; Baltensweiler, Andri; Kögel-Knabner, Ingrid; Polle, Andrea; Schloter, Michael; Simon, Judy; Rennenberg, Heinz

    2016-01-01

    European beech forests growing on marginal calcareous soils have been proposed to be vulnerable to decreased soil water availability. This could result in a large-scale loss of ecological services and economical value in a changing climate. In order to evaluate the potential consequences of this drought-sensitivity, we investigated potential species range shifts for European beech forests on calcareous soil in the 21st century by statistical species range distribution modelling for present day and projected future climate conditions. We found a dramatic decline by 78% until 2080. Still the physiological or biogeochemical mechanisms underlying the drought sensitivity of European beech are largely unknown. Drought sensitivity of beech is commonly attributed to plant physiological constraints. Furthermore, it has also been proposed that reduced soil water availability could promote nitrogen (N) limitation of European beech due to impaired microbial N cycling in soil, but this hypothesis has not yet been tested. Hence we investigated the influence of simulated climate change (increased temperatures, reduced soil water availability) on soil gross microbial N turnover and plant N uptake in the beech-soil interface of a typical mountainous beech forest stocking on calcareous soil in SW Germany. For this purpose, triple 15N isotope labelling of intact beech seedling-soil-microbe systems was combined with a space-for-time climate change experiment. We found that nitrate was the dominant N source for beech natural regeneration. Reduced soil water content caused a persistent decline of ammonia oxidizing bacteria and therefore, a massive attenuation of gross nitrification rates and nitrate availability in the soil. Consequently, nitrate and total N uptake of beech seedlings were strongly reduced so that impaired growth of beech seedlings was observed already after one year of exposure to simulated climatic change. We conclude that the N cycle in this ecosystem and here

  7. Climate Change Impairs Nitrogen Cycling in European Beech Forests

    Science.gov (United States)

    Dannenmann, Michael; Bilela, Silvija; Gasche, Rainer; Hanewinkel, Marc; Baltensweiler, Andri; Kögel-Knabner, Ingrid; Polle, Andrea; Schloter, Michael; Simon, Judy; Rennenberg, Heinz

    2016-01-01

    European beech forests growing on marginal calcareous soils have been proposed to be vulnerable to decreased soil water availability. This could result in a large-scale loss of ecological services and economical value in a changing climate. In order to evaluate the potential consequences of this drought-sensitivity, we investigated potential species range shifts for European beech forests on calcareous soil in the 21st century by statistical species range distribution modelling for present day and projected future climate conditions. We found a dramatic decline by 78% until 2080. Still the physiological or biogeochemical mechanisms underlying the drought sensitivity of European beech are largely unknown. Drought sensitivity of beech is commonly attributed to plant physiological constraints. Furthermore, it has also been proposed that reduced soil water availability could promote nitrogen (N) limitation of European beech due to impaired microbial N cycling in soil, but this hypothesis has not yet been tested. Hence we investigated the influence of simulated climate change (increased temperatures, reduced soil water availability) on soil gross microbial N turnover and plant N uptake in the beech-soil interface of a typical mountainous beech forest stocking on calcareous soil in SW Germany. For this purpose, triple 15N isotope labelling of intact beech seedling-soil-microbe systems was combined with a space-for-time climate change experiment. We found that nitrate was the dominant N source for beech natural regeneration. Reduced soil water content caused a persistent decline of ammonia oxidizing bacteria and therefore, a massive attenuation of gross nitrification rates and nitrate availability in the soil. Consequently, nitrate and total N uptake of beech seedlings were strongly reduced so that impaired growth of beech seedlings was observed already after one year of exposure to simulated climatic change. We conclude that the N cycle in this ecosystem and here

  8. Climate Change Impairs Nitrogen Cycling in European Beech Forests.

    Science.gov (United States)

    Dannenmann, Michael; Bimüller, Carolin; Gschwendtner, Silvia; Leberecht, Martin; Tejedor, Javier; Bilela, Silvija; Gasche, Rainer; Hanewinkel, Marc; Baltensweiler, Andri; Kögel-Knabner, Ingrid; Polle, Andrea; Schloter, Michael; Simon, Judy; Rennenberg, Heinz

    2016-01-01

    European beech forests growing on marginal calcareous soils have been proposed to be vulnerable to decreased soil water availability. This could result in a large-scale loss of ecological services and economical value in a changing climate. In order to evaluate the potential consequences of this drought-sensitivity, we investigated potential species range shifts for European beech forests on calcareous soil in the 21st century by statistical species range distribution modelling for present day and projected future climate conditions. We found a dramatic decline by 78% until 2080. Still the physiological or biogeochemical mechanisms underlying the drought sensitivity of European beech are largely unknown. Drought sensitivity of beech is commonly attributed to plant physiological constraints. Furthermore, it has also been proposed that reduced soil water availability could promote nitrogen (N) limitation of European beech due to impaired microbial N cycling in soil, but this hypothesis has not yet been tested. Hence we investigated the influence of simulated climate change (increased temperatures, reduced soil water availability) on soil gross microbial N turnover and plant N uptake in the beech-soil interface of a typical mountainous beech forest stocking on calcareous soil in SW Germany. For this purpose, triple 15N isotope labelling of intact beech seedling-soil-microbe systems was combined with a space-for-time climate change experiment. We found that nitrate was the dominant N source for beech natural regeneration. Reduced soil water content caused a persistent decline of ammonia oxidizing bacteria and therefore, a massive attenuation of gross nitrification rates and nitrate availability in the soil. Consequently, nitrate and total N uptake of beech seedlings were strongly reduced so that impaired growth of beech seedlings was observed already after one year of exposure to simulated climatic change. We conclude that the N cycle in this ecosystem and here

  9. Classification of change detection and change blindness from near-infrared spectroscopy signals

    OpenAIRE

    Tanaka, Hirokazu; Katura, Takusige

    2011-01-01

    Using a machine-learning classification algorithm applied to near-infrared spectroscopy (NIRS) signals, we classify a success (change detection) or a failure (change blindness) in detecting visual changes for a change-detection task. Five subjects perform a change-detection task, and their brain activities are continuously monitored. A support-vector-machine algorithm is applied to classify the change-detection and change-blindness trials, and correct classification probability of 70–90% is o...

  10. Change of translational-rotational coupling in liquids revealed by field-cycling {sup 1}H NMR

    Energy Technology Data Exchange (ETDEWEB)

    Meier, R.; Schneider, E.; Rössler, E. A. [Experimentalphysik II, Universität Bayreuth, D-95440 Bayreuth (Germany)

    2015-01-21

    Applying the field-cycling nuclear magnetic resonance technique, the frequency dependence of the {sup 1}H spin-lattice relaxation rate, R{sub 1}(ω)=T{sub 1}{sup −1}(ω), is measured for propylene glycol (PG) which is increasingly diluted with deuterated chloroform. A frequency range of 10 kHz–20 MHz and a broad temperature interval from 220 to about 100 K are covered. The results are compared to those of experiments, where glycerol and o-terphenyl are diluted with their deuterated counter-part. Reflecting intra- as well as intermolecular relaxation, the dispersion curves R{sub 1}(ω,x) (x denotes mole fraction PG) allow to extract the rotational time constant τ{sub rot}(T, x) and the self-diffusion coefficient D(T, x) in a single experiment. The Stokes-Einstein-Debye (SED) relation is tested in terms of the quantity D(T, x) τ{sub rot}(T, x) which provides a measure of an effective hydrodynamic radius or equivalently of the spectral separation of the translational and the rotational relaxation contribution. In contrast to o-terphenyl, glycerol and PG show a spectral separation much larger than suggested by the SED relation. In the case of PG/chloroform mixtures, not only an acceleration of the PG dynamics is observed with increasing dilution but also the spectral separation of rotational and translational relaxation contributions continuously decreases. Finally, following a behavior similar to that of o-terphenyl already at about x = 0.6; i.e., while D(T, x) τ{sub rot}(T, x) in the mixture is essentially temperature independent, it strongly increases with x signaling thus a change of translational-rotational coupling. This directly reflects the dissolution of the hydrogen-bond network and thus a change of solution structure.

  11. Web traffic and firm performance

    DEFF Research Database (Denmark)

    Farooq, Omar; Aguenaou, Samir

    2013-01-01

    Does the traffic generated by websites of firms signal anything to stock market participants? Does higher web-traffic translate into availability of more information and therefore lower agency problems? And if answers to above questions are in affirmative, does higher web-traffic traffic translate...... into better firm performance? This paper aims to answer these questions by documenting a positive relationship between the extent of web-traffic and firm performance in the MENA region during the 2010. We argue that higher web-traffic lowers the agency problems in firms by disseminating more information...... to stock market participants. Consequently, lower agency problems translate into better performance. Furthermore, we also show that agency reducing role of web-traffic is more pronounced in regimes where information environment is already bad. For example, our results show stronger impact of web...

  12. Effects of Traffic Lights on CA Traffic Model

    Institute of Scientific and Technical Information of China (English)

    SuweiFENG; GuoqingGU

    1997-01-01

    Cellular automaton traffic models can include various factors in traffic system with simple regulations and the corresponding computations and simulations are rather convenient and effective.In this paper,the Biham-Middleton-Levine model(briefly saying the BML model)is improved by removing its limitation of synchronized change of traffic lights.In new model,the traffic light at each crossing could arbitrarily change its starting time and tempo of variation and hence the model could more realistically describe the influence of traffic lights on the performance of traffic systems.The cases of traffic light with unsynchronized starting time and different tempo of variation are simulated in this paper.

  13. Associations between Recreational and Commuter Cycling, Changes in Cycling, and Type 2 Diabetes Risk: A Cohort Study of Danish Men and Women.

    Directory of Open Access Journals (Sweden)

    Martin G Rasmussen

    2016-07-01

    Full Text Available Cycling is a recreational activity and mode of commuting with substantial potential to improve public health in many countries around the world. The aim of this study was to examine prospective associations between recreational and commuter cycling, changes in cycling habits, and risk of type 2 diabetes (T2D in Danish adults from the Diet, Cancer and Health cohort study.At baseline from 1993 to 1997, 24,623 men and 27,890 women from Denmark, 50-65 y of age and free of T2D and other chronic diseases, underwent a number of assessments, including completing a lifestyle questionnaire also addressing cycling habits. Approximately 5 y later, at a second examination, participants completed a new, updated lifestyle questionnaire. Cox regression was used to estimate hazard ratios (HRs of incident T2D registered in the Danish National Diabetes Registry, according to recreational and commuter cycling and changes in cycling habits, with adjustment for a priori known T2D risk factors. During 743,245.4 person-years of follow-up (mean follow-up 14.2 y, 6,779 incident cases of T2D were documented. Multivariable adjusted HRs (95% confidence interval [CI] were 1, 0.87 (0.82, 0.93, 0.83 (0.77, 0.89, 0.80 (0.74, 0.86 and 0.80 (0.74, 0.87 (p for trend = 300 min/wk of total cycling (recreational and commuter cycling, respectively. In analysis of seasonal cycling, multivariable adjusted HRs (95% CI were 1, 0.88 (0.83, 0.94, and 0.80 (0.76, 0.85 for non-cyclists, seasonal cyclists (those cycling only in summer or winter, and those cycling during both summer and winter, respectively. How changes in total cycling from baseline to the second examination affected risk was also investigated, and multivariable adjusted HRs (95% CI were 1, 0.88 (0.78, 1.01, 0.80 (0.69, 0.91, and 0.71 (0.65, 0.77 for non-cyclists and for those who ceased, initiated, or continued cycling between baseline and the second examination, respectively. Lastly, in the analysis of commuter cycling

  14. Vegetation and Pollen signals of the Anthropocene: Changing signals, changing scales

    Science.gov (United States)

    Goring, S. J.; Williams, J. W.; Kujawa, E. R.; Dawson, A.

    2015-12-01

    The signals of the onset of Euro-American settlement in North America are clear and pervasive, but there is a disconnect between pollen and vegetation signals, both prior to and following EuroAmerican settlement. Vegetation shifts with respect to climate are induced by biased land use patterns in the upper Midwestern United States, but because pollen can be transported long distances, and because the granularity of the pollen signal, obtained from lake sediments and interpolated across the landscape, is often much lower than for forest and land cover data, the apparent influence of climate in structuring vegetation is much stronger for pollen than for vegetation. We examine the impacts of widespread human land use on taxon boundaries in the northeastern United States, both prior to widespread EuroAmerican Settlement and under modern conditions, for both pollen and forest cover and compare these distributions and the forest community ecotones to climate and physiographic features. We show that following EuroAmerican settlement vegetation ecotone sensitivity to both climate and physiography is much weaker than prior to settlement, while for pollen climate remains the dominant driver, but the presence of cosmopolitan "weedy" taxa produces a landscape that is more homogeneous, and again shows weaker sensitivity to climate and physiographic thresholds. The drivers for decreased sentitivity are largely the result of broad-scale homogenization, the overall loss of strong vegetation ecotones in the region. Pollen is less sensitive to this decline because the influence of heavy producers has already resulted in an apparent homogenization of the landscape. This has implications for past land-cover reconstruction and our understanding of the strengths of climate and physiography in structuring vegetation cover over long time scales.

  15. Synchronized Northern Hemisphere climate change and solar magnetic cycles during the Maunder Minimum.

    Science.gov (United States)

    Yamaguchi, Yasuhiko T; Yokoyama, Yusuke; Miyahara, Hiroko; Sho, Kenjiro; Nakatsuka, Takeshi

    2010-11-30

    The Maunder Minimum (A.D. 1645-1715) is a useful period to investigate possible sun-climate linkages as sunspots became exceedingly rare and the characteristics of solar cycles were different from those of today. Here, we report annual variations in the oxygen isotopic composition (δ(18)O) of tree-ring cellulose in central Japan during the Maunder Minimum. We were able to explore possible sun-climate connections through high-temporal resolution solar activity (radiocarbon contents; Δ(14)C) and climate (δ(18)O) isotope records derived from annual tree rings. The tree-ring δ(18)O record in Japan shows distinct negative δ(18)O spikes (wetter rainy seasons) coinciding with rapid cooling in Greenland and with decreases in Northern Hemisphere mean temperature at around minima of decadal solar cycles. We have determined that the climate signals in all three records strongly correlate with changes in the polarity of solar dipole magnetic field, suggesting a causal link to galactic cosmic rays (GCRs). These findings are further supported by a comparison between the interannual patterns of tree-ring δ(18)O record and the GCR flux reconstructed by an ice-core (10)Be record. Therefore, the variation of GCR flux associated with the multidecadal cycles of solar magnetic field seem to be causally related to the significant and widespread climate changes at least during the Maunder Minimum.

  16. Metabolic Changes Underlying Bold Signal Variations after Administration of Zolpidem

    International Nuclear Information System (INIS)

    Zolpidem is a non-benzodiazepine drug belonging to the imidazopiridine class, which has selectivity for stimulating the effect of gamma aminobutyric acid [GABA] and is used for the therapy of insomnia. Nonetheless, several reports have been published over recent years about a paradoxical arousing effect of Zolpidem in patients with severe brain damage. We studied a PVS case using 1H-MRS and BOLD signal, before and after Zolpidem administration. Significantly increased BOLD signal was localized in left frontal superior cortex, bilateral cingulated areas, left thalamus and right head of the caudate nucleus. A transient activation was observed in frontal cortex, comprising portions of anterior cingulate, medial, and orbito-frontal cortices. Additionally, significant pharmacological activation in sensory-motor cortex is observed 1 hour after Zolpidem intake. Significant linear correlations of BOLD signal changes were found with primary concentrations of NAA, Glx and Lac in the right frontal cortex. We discussed that when Zolpidem attaches to the modified GABA receptors of the neurodormant cells, dormancy is switched off, inducing brain activation. This might explain the significant correlations of BOLD signal changes and 1H-MRS metabolites in our patient. We concluded that 1H-MRS and BOLD signal assessment might contribute to study neurovascular coupling in PVS cases after Zolpidem administration. Although this is a report of a single case, considering our results we recommend to apply this methodology in series of PVS and MCS patients. (author)

  17. Climate Change Signal Analysis for Northeast Asian Surface Temperature

    Institute of Scientific and Technical Information of China (English)

    Jeong-Hyeong LEE; Byungsoo KIM; Keon-Tae SOHN; Won-Tae KOWN; Seung-Ki MIN

    2005-01-01

    Climate change detection, attribution, and prediction were studied for the surface temperature in the Northeast Asian region using NCEP/NCAR reanalysis data and three coupled-model simulations from ECHAM4/OPYC3, HadCM3, and CCCma GCMs (Canadian Centre for Climate Modeling and Analysis general circulation model). The Bayesian fingerprint approach was used to perform the detection and attribution test for the anthropogenic climate change signal associated with changes in anthropogenic carbon dioxide (CO2) and sulfate aerosol (SO42-) concentrations for the Northeast Asian temperature. It was shown that there was a weak anthropogenic climate change signal in the Northeast Asian temperature change. The relative contribution of CO2 and SOl- effects to total temperature change in Northeast Asia was quantified from ECHAM4/OPYC3 and CCCma GCM simulations using analysis of variance. For the observed temperature change for the period of 1959-1998, the CO2 effect contributed 10%-21% of the total variance and the direct cooling effect of SO42- played a less important role (0% 7%) than the CO2effect. The prediction of surface temperature change was estimated from the second CO2+SO24- scenario run of ECHAM4/OPYC3 which has the least error in the simulation of the present-day temperature field near the Korean Peninsula. The result shows that the area-mean surface temperature near the Korean Peninsula will increase by about 1.1° by the 2040s relative to the 1990s.

  18. Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway

    Science.gov (United States)

    Wang, Gang; Cao, Rui; Wang, Yongzhi; Qian, Guofeng; Dan, Han C.; Jiang, Wei; Ju, Lingao; Wu, Min; Xiao, Yu; Wang, Xinghuan

    2016-01-01

    Simvastatin is currently one of the most common drugs for old patients with hyperlipidemia, hypercholesterolemia and atherosclerotic diseases by reducing cholesterol level and anti-lipid properties. Importantly, simvastatin has also been reported to have anti-tumor effect, but the underlying mechanism is largely unknown. We collected several human bladder samples and performed microarray. Data analysis suggested bladder cancer (BCa) was significantly associated with fatty acid/lipid metabolism via PPAR signalling pathway. We observed simvastatin did not trigger BCa cell apoptosis, but reduced cell proliferation in a dose- and time-dependent manner, accompanied by PPARγ-activation. Moreover, flow cytometry analysis indicated that simvastatin induced cell cycle arrest at G0/G1 phase, suggested by downregulation of CDK4/6 and Cyclin D1. Furthermore, simvastatin suppressed BCa cell metastasis by inhibiting EMT and affecting AKT/GSK3β. More importantly, we found that the cell cycle arrest at G0/G1 phase and the alterations of CDK4/6 and Cyclin D1 triggered by simvastatin could be recovered by PPARγ-antagonist (GW9662), whereas the treatment of PPARα-antagonist (GW6471) shown no significant effects on the BCa cells. Taken together, our study for the first time revealed that simvastatin inhibited bladder cancer cell proliferation and induced cell cycle arrest at G1/G0 phase via PPARγ signalling pathway. PMID:27779188

  19. Molecular changes of DOM cycling in forest ecosystem

    Science.gov (United States)

    Hara, M.; Ohashi, M.; Piirainen, S.; Kortelainen, P.; Finer, L.; Kumagai, T.; Takahashi, K.; Sugiyama, Y.

    2011-12-01

    Fresh water is essential for sustaining all the life on the earth. Most of the fresh water available for human is stored in forest ecosystem in the forms of soil and ground water. Therefore, the chemical compositions of fresh water could be controlled by the forest ecosystem. Dissolved Organic Matter (DOM) is one of the main dissolved components of water. Since it controls the cycling processes of both organic and inorganic matters in water by variety of physical, chemical, and biochemical interactions, chatacterization of DOM in both qualitatively and quantitatively is very important. However, molecular-level study in DOM has been behind due to technological difficulties. Over the past years, high resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) which enables us to identify individual molecular species of DOM had been hugely developed and brought radical changes to the analysis of many different substances in molecular level. The purpose of this study is to observe the cycling and alteration process of DOM in the forest ecosystem substantially using FT-ICR MS. We analyzed DOM samples by FT-ICR MS to determine the molecular-level characteristics of DOM. We also analyzed dissolved organic carbon (DOC) and characteristics of fluorescence spectra to elucidate the bulk characteristics of DOM in the forest ecosystem. In forest ecosystem, DOC increased from bulk deposition (1.0~3.3 mgC/L) and throughfall (0.8~3.6 mgC/L) to soil water of the A- (4.7~28.6 mgC/L) and B-horizon (4.5~29.2 mgC/L). DOC decreased as the water percolated through the soil deeper to ground water (0.3~1.7 mgC/L). In the whole forest ecosystem, fluorescence spectra showed strong humic-like fluorescence peaks rather than protein-like peaks. Each sample's result of FT-ICR MS including bulk deposition, throughfall, soil waters in different depths, and groundwater showed different molecular characteristics between one another. These results suggest that DOM in water is

  20. Road Traffic Injuries

    Institute of Scientific and Technical Information of China (English)

    WANG Zheng-guo

    2005-01-01

    @@ As everybody knows that automobiles have been greatly changing our life. However, everything has two sides, motor vehicles have also caused a huge number of people's deaths, injuries and property damage. Traffic crashes are perhaps the number one public health problem in developed countries [1]. In the United States, pre-retirement years of life lost in traffic crashes are more than that of the two combined leading diseases: cancer and heart disease [1]. Today road traffic crash (RTC) ranks 11th in leading cause of death and accounts for 2.1% of all deaths globally.

  1. Floral colour change as a potential signal to pollinators.

    Science.gov (United States)

    Ruxton, Graeme D; Schaefer, H Martin

    2016-08-01

    Colour change in flowers (with age and/or after pollination) is taxonomically widespread, has evolved repeatedly, and has a range of putative selective benefits linked to modifying pollinator behaviour; however, this phenomenon seems paradoxically uncommon. We explore this paradox by reviewing the empirical evidence and argue that the evolution and maintenance of floral colour change as a signal to modify pollinator behaviour require special ecological circumstances that will often not be met across a plant population for a sustained number of generations, which potentially explains the scarcity of this phenomenon. We discuss alternative explanations for floral colour change and potentially fruitful lines of future research. PMID:27428780

  2. Extracting the respiration cycle lengths from ECG signal recorded with bed sheet electrodes

    International Nuclear Information System (INIS)

    A method for recognizing the respiration cycle lengths from the electrocardiographic (ECG) signal recorded with textile electrodes that are attached to a bed sheet is proposed. The method uses two features extracted from the ECG that are affected by the respiration: respiratory sinus arrhythmia and the amplitude of the R-peaks. The proposed method was tested in one hour long recordings with ten healthy young adults. A relative mean absolute error of 5.6 % was achieved when the algorithm was able to provide a result for approximately 40 % of the time. 90 % of the values were within 0.5 s and 97 % within 1 s from the reference respiration value. In addition to the instantaneous respiration cycle lengths, also the mean values during 1 and 5 minutes epochs are calculated. The effect of the ECG signal source is evaluated by calculating the result also from the simultaneously recorded reference ECG signal. The acquired respiration information can be used in the estimation of sleep quality and the detection of sleep disorders

  3. Extracting the respiration cycle lengths from ECG signal recorded with bed sheet electrodes

    Science.gov (United States)

    Vehkaoja, A.; Peltokangas, M.; Lekkala, J.

    2013-09-01

    A method for recognizing the respiration cycle lengths from the electrocardiographic (ECG) signal recorded with textile electrodes that are attached to a bed sheet is proposed. The method uses two features extracted from the ECG that are affected by the respiration: respiratory sinus arrhythmia and the amplitude of the R-peaks. The proposed method was tested in one hour long recordings with ten healthy young adults. A relative mean absolute error of 5.6 % was achieved when the algorithm was able to provide a result for approximately 40 % of the time. 90 % of the values were within 0.5 s and 97 % within 1 s from the reference respiration value. In addition to the instantaneous respiration cycle lengths, also the mean values during 1 and 5 minutes epochs are calculated. The effect of the ECG signal source is evaluated by calculating the result also from the simultaneously recorded reference ECG signal. The acquired respiration information can be used in the estimation of sleep quality and the detection of sleep disorders.

  4. Multi-objective optimization method for signal timing of urban traffic intersection%城市道路交叉口信号配时多目标优化方法研究

    Institute of Scientific and Technical Information of China (English)

    郭鹏飞; 徐海黎; 树爱兵; 潘腊青; 沈标

    2016-01-01

    针对目前交叉口信号配时优化目标单一、综合运行效率不高的问题,提出一种交叉口信号配时多目标优化方法。考虑绿灯时间、周期长度和饱和度等约束条件,通过加权系数法定义代价函数,使交叉口的延误时间、停车次数和通行能力在某种程度上达到最优。基于免疫克隆算法在处理多目标问题中具有最优解分布宽广性、均匀性好等特点,引入环境变异算子,提出环境变异免疫克隆算法对模型求解,增强了算法的全局搜索能力,提高了解的质量。仿真结果表明,与传统配时方法和改进粒子群算法相比,该文方法能有效减少信号交叉口的延误时间和停车次数,提高交叉口的运行效率。%To solve the problems of single optimization objective and low efficiency in signal timing,a novel multi⁃objective optimization method for signal timing of intersections is proposed. In consideration of constraint conditions of green⁃light dura⁃tion,cycle length and saturability,the cost function is defined by weighted coefficient method to make delay time,parking times and traffic capacity of intersections optimum to some extent. Based on the characteristics of uniformity and wide⁃distribu⁃tion of optimal solution while immune clone algorithm(ICA)is used to solve multi⁃objective problems,a new environment muta⁃tion operator was introduced,and the environment mutation ICA was proposed for model solution,which enhanced the global searching ability of the algorithm and improved the solution quality. The simulation results reveal that,compared with the tradi⁃tional timing method and inertia weight particle swarm algorithm,the presented method can efficiently reduce average delay, parking times of intersections,and improve the efficiency of traffic signal control.

  5. The effect of esmolol on corrected-QT interval, corrected-QT interval dispersion changes seen during anesthesia induction in hypertensive patients taking an angiotensin-converting enzyme inhibitor

    Directory of Open Access Journals (Sweden)

    Zahit Çeker

    2015-02-01

    Full Text Available BACKGROUND AND OBJECTIVES: The importance of minimizing the exaggerated sympatho-adrenergic responses and QT interval and QT interval dispersion changes that may develop due to laryngoscopy and tracheal intubation during anesthesia induction in the hypertensive patients is clear. Esmolol decreases the hemodynamic response to laryngoscopy and intubation. However, the effect of esmolol in decreasing the prolonged QT interval and QT interval dispersion as induced by laryngoscopy and intubation is controversial. We investigated the effect of esmolol on the hemodynamic, and corrected-QT interval and corrected-QT interval dispersion changes seen during anesthesia induction in hypertensive patients using angiotensin converting enzyme inhibitors. METHODS: 60 ASA I-II patients, with essential hypertension using angiotensin converting enzyme inhibitors were included in the study. The esmolol group received esmolol at a bolus dose of 500 mcg/kg followed by a 100 mcg/kg/min infusion which continued until the 4th min after intubation. The control group received 0.9% saline similar to the esmolol group. The mean blood pressure, heart rate values and the electrocardiogram records were obtained as baseline values before the anesthesia, 5 min after esmolol and saline administration, 3 min after the induction and 30 s, 2 min and 4 min after intubation. RESULTS: The corrected-QT interval was shorter in the esmolol group (p = 0.012, the corrected-QT interval dispersion interval was longer in the control group (p = 0.034 and the mean heart rate was higher in the control group (p = 0.022 30 s after intubation. The risk of arrhythmia frequency was higher in the control group in the 4-min period following intubation (p = 0.038. CONCLUSION: Endotracheal intubation was found to prolong corrected-QT interval and corrected-QT interval dispersion, and increase the heart rate during anesthesia induction with propofol in hypertensive patients using angiotensin converting

  6. Problems of Current Setup of Traffic Signal Lights and the Solutions%我国现行道路交通信号灯设置中的问题及对策

    Institute of Scientific and Technical Information of China (English)

    孙毅然

    2014-01-01

    交通信号灯是加强道路交通管理,减少交通事故发生,提高道路通行效率不可或缺的重要工具。但我国部分城市的交通信号灯的设置,仍然存在严重的交通安全隐患。指出了交通信号灯设置和交叉口存在的主要问题,并从软件和硬件两方面提出了具体可行的对策建议。%Traffic signal lights aredispensable devices of enhancing road traffic management and reducing traffic ac -cidents .But seriously potential safety issues are still existing because of the setups of traffic signal lights in some cit -ies.This article dedicates the main existing problems of the setups of traffic signal lights and pay attention to the in-tersection’ s concrete condition , then proposes practically implemental suggestion in software and hardware .

  7. Air traffic generation for new terminal area air traffic management concepts design and evaluation

    OpenAIRE

    Besada Portas, Juan Alberto; Marquinez Prado, Iñigo; Portillo Garcia, Javier Ignacio; Miguel Vela, Gonzalo de; Bernardos Barbolla, Ana M.

    2015-01-01

    This paper describes two systems that can be used to obtain realistic random traffic samples in a terminal area: a real traffic analyser and a synthetic traffic generator. These two systems allow the air traffic management (ATM) engineer to gain insight on the traffic structure of the area under analysis, and allow obtaining realistic traffic samples enabling the evaluation of new operational concepts, the validation or system performance measurement after procedure changes, the analysis of A...

  8. Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle.

    Science.gov (United States)

    Dupont, Joëlle; Scaramuzzi, Rex J

    2016-06-01

    Data derived principally from peripheral tissues (fat, muscle and liver) show that insulin signals via diverse interconnecting intracellular pathways and that some of the major intersecting points (known as critical nodes) are the IRSs (insulin receptor substrates), PI3K (phosphoinositide kinase)/Akt and MAPK (mitogen-activated protein kinase). Most of these insulin pathways are probably also active in the ovary and their ability to interact with each other and also with follicle-stimulating hormone (FSH) and luteinizing hormone (LH) signalling pathways enables insulin to exert direct modulating influences on ovarian function. The present paper reviews the intracellular actions of insulin and the uptake of glucose by ovarian tissues (granulosa, theca and oocyte) during the oestrous/menstrual cycle of some rodent, primate and ruminant species. Insulin signals through diverse pathways and these are discussed with specific reference to follicular cell types (granulosa, theca and oocyte). The signalling pathways for FSH in granulosa cells and LH in granulosa and theca cells are summarized. The roles of glucose and of insulin-mediated uptake of glucose in folliculogenesis are discussed. It is suggested that glucose in addition to its well-established role of providing energy for cellular function may also have insulin-mediated signalling functions in ovarian cells, involving AMPK (AMP-dependent protein kinase) and/or hexosamine. Potential interactions of insulin signalling with FSH or LH signalling at critical nodes are identified and the available evidence for such interactions in ovarian cells is discussed. Finally the action of the insulin-sensitizing drugs metformin and the thiazolidinedione rosiglitazone on follicular cells is reviewed. PMID:27234585

  9. DYNAMIC OF CHANGES OF BLOOD PLASMA ENERGY METABOLISM PARAMETERS IN SUCKLING COWS DURING CALVING INTERVAL

    Directory of Open Access Journals (Sweden)

    Ales Pavlik

    2015-02-01

    Full Text Available In this study, effect of environmental condition changes during gazing period on energy metabolism parameters was investigated. Totally 40 Aberdeen Angus cows were selected for observation. Calving all of cows was situated into March. The feeding ration for the animals was comprised by pasture during the grazing period and corn silage, hay and granulated distiller’s grains during the winter period. At average age 9 days before calving, and subsequently 10, 81, 151, 189 and 273 days after calving, blood was sampled and analysed for glucose and NEFA (non-esterified fatty acid concentrations on KONELAB T20xt automatic analyser (Thermo Fisher Scientific, Finland and currently available commercial kits (Biovendor-Laboratorni medicina, Czech Republic. A rapid increase (p < 0.05 of glucose concentration was detected in blood plasma of cows in period before calving to 81 days post partum. Average value of glucose concentration at 273 days postpartum was significant (p < 0.05 lower comparing to day 189. The highest concentrations of NEFA in blood plasma of cows were found at 10 day postpartum. After that, during the persisted higher temperature period the NEFA concentration decreased significantly (p < 0.01 till 189 days postpartum. At the end of monitored period concentration of NEFA in blood plasma significantly decreased (p < 0.05. Changes of hot and cold season during the grazing period probably according to forage quality and had significant effects on blood plasma NEFA and glucose concentrations.

  10. Glacial-interglacial water cycle, global monsoon and atmospheric methane changes

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Zhengtang; Wu, Haibin [Chinese Academy of Sciences, Key Laboratory of Cenozoic Geology and Environment, Institute of Geology and Geophysics, Beijing (China); Zhou, Xin [Chinese Academy of Sciences, Key Laboratory of Cenozoic Geology and Environment, Institute of Geology and Geophysics, Beijing (China); University of Science and Technology of China, School of Earth and Space Sciences and Institute of Polar Environment, Hefei (China)

    2012-09-15

    The causes of atmospheric methane (CH{sub 4}) changes are still a major contention, in particular with regards to the relative contributions of glacial-interglacial cycles, monsoons in both hemispheres and the late Holocene human intervention. Here, we explore the CH{sub 4} signals in the Antarctic EPICA Dome C and Vostok ice records using the methods of timeseries analyses and correlate them with insolation and geological records to address these issues. The results parse out three distinct groups of CH{sub 4} signals attributable to different drivers. The first group ({proportional_to}80% variance), well tracking the marine {delta}{sup 18}O record, is attributable to glacial-interglacial modulation on the global water cycle with the effects shared by wetlands at all latitudes, from monsoonal and non-monsoonal regions in both hemispheres. The second group ({proportional_to}15% variance), centered at the {proportional_to}10-kyr semi-precession frequency, is linkable with insolation-driven tropical monsoon changes in both hemispheres. The third group ({proportional_to}5% variance), marked by millennial frequencies, is seemingly related with the combined effect of ice-volume and bi-hemispheric insolation changes at the precession bands. These results indicate that bi-hemispheric monsoon changes have been a constant driver of atmospheric CH{sub 4}. This mechanism also partially explains the Holocene CH{sub 4} reversal since {proportional_to}5 kyr BP besides the human intervention. In the light of these results, we propose that global monsoon can be regarded as a system consisting of two main integrated components, one primarily driven by the oscillations of Inter-Tropical Convergence Zone (ITCZ) in response to the low-latitude summer insolation changes, anti-phase between the two hemispheres (i.e. the ITCZ monsoon component); and another modulated by the glacial-interglacial cycles, mostly synchronous at the global scale (i.e. the glacial-interglacial monsoon

  11. From Traffic Flow to Economic System

    Science.gov (United States)

    Bando, M.

    The optimal velocity model which is applied to traffic flow phenomena explains a spontaneous formation of traffic congestion. We discuss why the model works well in describing both free-flow and congested flow states in a unified way. The essential ingredient is that our model takes account of a sort of time delay in reacting to a given stimulus. This causes instability of many-body system, and yields a kind of phase transition above a certain critical density. Especially there appears a limit cycle on the phase space along which individual vehicle moves, and they show cyclic behavior. Once that we recognize the mechanism the same idea can be applied to a variety of phenomena which show cyclic behavior observed in many-body systems. As an example of such applications, we investigate business cycles commonly observed in economic system. We further discuss a possible origin of a kind of cyclic behavior observed in climate change.

  12. Cellular Automata Based Traffic Flow Simulation and Actuated Signal Control Strategy%基于CA方法的交通流数值模拟及信号灯感应控制策略研究

    Institute of Scientific and Technical Information of China (English)

    陈晨; 陈建桥

    2011-01-01

    According to the theory of cellular automata ( CA), the urban traffic flows at 4 intersections were investigated and a set of discrete equations were proposed to describe the traffic dynamics. The effect of two signal control strategies, i.e., synchronous timing control and actuated control, on traffic flow were discussed. Simulation results show that ( 1 ) the effect of signal control strategies is related to the density of traffic flow; (2) and there exists a certain range of actuated control parameters in which the efficiency of traffic flow can be optimized. Therefore, in order to ensure the efficiency of traffic flow, one the proper signal control strategy should be chosen for different global densities of traffic flow.%采用细胞自动机方法(Cellular Automata:CA)模拟含4个路口的城市道路交通流状态,并通过离散方程描述车辆的运动过程.研究了信号灯控制策略(同步定时控制及感应控制)对交通流状态的影响.数值模拟结果表明,信号灯对交通流的影响与道路中车辆密度有关,同时,感应控制参数的选取存在一合理的取值范围,可优化交通流通行效率.因此,为保证交通流的通行效率,应针对不同的车辆密度,选取适当的信号灯控制方式.

  13. Change detection for traffic monitoring in TerraSAR-X imagery

    OpenAIRE

    Palubinskas, Gintautas; Runge, Hartmut

    2008-01-01

    In this paper the changes occurring in two images acquired at two different time moments are analyzed. In particular the interest is in the changes of filling grade of car-parks or even detecting stopped vehicles on the congested or jammed roads. As input to the change detection processor can serve two repeat-pass single channel images acquired by any airborne or space borne SAR satellite sensor. Each channel is focused, calibrated and processed to a single look slant range complex SAR image....

  14. Modelling the carbon cycle though Neoproterozoic Earth system changes

    Science.gov (United States)

    Bjerrum, C. J.; Canfield, D. E.

    2011-12-01

    The Neoproterozoic-Cambrian records major changes in geochemical proxies as a result of a profound reorganization of the Earth system. Extensive glaciations and the first oxygenation of the deep ocean with a shift from sulfidic/ferruginous conditions to more oxic conditions was accompanied by the radiation of the first animals. The reorganization was also recorded in enigmatic large-amplitude fluctuations in the isotopic composition of marine carbonate carbon (δ13CIC ), were only some are associated with major known glaciations. The carbon isotope events seem to grow in amplitude through the Neoproterozoic culminating in the Shuram anomaly - the largest in Earth history. The δ13CIC events are also accompanied by changes in the isotope composition of marine organic carbon (δ13COC), where the co-variation of δ13CIC and δ13COC seems to evolve from markedly positive relationship over a subdued δ13COC variation and an almost inverse pattern. There is limited understanding as to why or how the structure of these isotope events evolved over time and how these events may tie to the reorganization of the Earth system. We use our published quantitative model of the Shuram anomaly to explore carbon cycle dynamics during the Neoproterozoic. By changing in pre-event atmosphere-ocean chemistry we explore which factors contribute to the observed patterns of the large Neoproterozoic carbon isotope events. In particular, decreasing atmospheric CO2 and a slight increase of oxygen together with an increasing CO source from rising DOC concentrations results in progressively larger event amplitudes with changing co-variation between δ13CIC and δ13COC , culminating with the structure observed for the Shurum-Wonaka anomaly in the Ediacaran. In our model, the carbon isotope excursions were driven by methane from sediment-hosted clathrate hydrate deposits. Being a powerful greenhouse gas, methane increased temperature and melted icecaps. These combined to produce a negative 18O

  15. Driver’s Awareness and Lane Changing Maneuver in Traffic Flow based on Cellular Automaton Model

    Directory of Open Access Journals (Sweden)

    Kohei Arai

    2015-08-01

    Full Text Available Effect of driver’s awareness (e.g., to estimate the speed and arrival time of another vehicle on the lane changing maneuver is discussed. “Scope awareness” is defined as the visibility which is required for the driver to make a visual perception about road condition and the speed of vehicle that appears in the target lane for lane changing in the road. Cellular automaton based simulation model is created and applied to simulation studies for driver awareness behavior. This study clarifies relations between the lane changing behavior and the scope awareness parameter that reflects driver behavior. Simulation results show that the proposed model is valid for investigation of the important features of lane changing maneuver.

  16. Re-configurable digital receiver for optically envelope detected half cycle BPSK and MSK radio-on-fiber signals

    DEFF Research Database (Denmark)

    Guerrero Gonzalez, Neil; Prince, Kamau; Zibar, Darko;

    2011-01-01

    novel digital receiver consists of a digital signal processing unit integrating functions such as filtering, peak-powers detection, symbol synchronization and signal demodulation for optically envelope detected half-cycle binary phase-shift-keying and minimum-shift-keying signals. Furthermore, radio......-frequency signal down-conversion is not required in our proposed approach; simplifying evens more the optical receiver front-end. We experimentally demonstrate error-free optical transmission (bit-error rate corresponding to 10−3 related to FEC-compatible levels) for both 416.6 Mbit/s half-cycle binary phase...

  17. Cervical cancer screening in Australia: modelled evaluation of the impact of changing the recommended interval from two to three years

    Directory of Open Access Journals (Sweden)

    Howard Kirsten

    2010-11-01

    Full Text Available Abstract Background The National Cervical Screening Program in Australia currently recommends that sexually active women between the ages of 18-70 years attend routine screening every 2 years. The publically funded National HPV Vaccination Program commenced in 2007, with catch-up in females aged 12-26 years conducted until 2009; and this may prompt consideration of whether the screening interval and other aspects of the organized screening program could be reviewed. The aim of the current evaluation was to assess the epidemiologic outcomes and cost implications of changing the recommended screening interval in Australia to 3 years. Methods We used a modelling approach to evaluate the effects of moving to a 3-yearly recommended screening interval. We used data from the Victorian Cervical Cytology Registry over the period 1997-2007 to model compliance with routine screening under current practice, and registry data from other countries with 3-yearly recommendations to inform assumptions about future screening behaviour under two alternative systems for screening organisation - retention of a reminder-based system (as in New Zealand, or a move to a call-and-recall system (as in England. Results A 3-yearly recommendation is predicted to be of similar effectiveness to the current 2-yearly recommendation, resulting in no substantial change to the total number of incident cervical cancer cases or cancer deaths, or to the estimated 0.68% average cumulative lifetime risk of cervical cancer in unvaccinated Australian women. However, a 3-yearly screening policy would be associated with decreases in the annual number of colposcopy and biopsy procedures performed (by 4-10% and decreases in the number of treatments for pre-invasive lesions (by 2-4%. The magnitude of the decrease in the number of diagnostic procedures and treatments would depend on the method of screening organization, with call-and-recall screening associated with the highest reductions. The

  18. A new solar signal: Average maximum sunspot magnetic fields independent of activity cycle

    CERN Document Server

    Livingston, William

    2016-01-01

    Over the past five years, 2010-2015, we have observed, in the near infrared (IR), the maximum magnetic field strengths for 4145 sunspot umbrae. Herein we distinguish field strengths from field flux. (Most solar magnetographs measure flux). Maximum field strength in umbrae is co-spatial with the position of umbral minimum brightness (Norton and Gilman, 2004). We measure field strength by the Zeeman splitting of the Fe 15648.5 A spectral line. We show that in the IR no cycle dependence on average maximum field strength (2050 G) has been found +/- 20 Gauss. A similar analysis of 17,450 spots observed by the Helioseismic and Magnetic Imager onboard the Solar Dynamics Observatory reveal the same cycle independence +/- 0.18 G., or a variance of 0.01%. This is found not to change over the ongoing 2010-2015 minimum to maximum cycle. Conclude the average maximum umbral fields on the Sun are constant with time.

  19. The changing role of dust in biogeochemical cycling

    Science.gov (United States)

    Neff, J. C.; Reynolds, R. L.; Farmer, G. L.; Reheis, M.

    2007-12-01

    Dust emission and deposition have the potential to deplete and enrich ecosystems of mineral resources essential to life. In many parts of the world, and particularly in semi-arid settings, wind erosion of soils and the subsequent long-distance transport and deposition of mineral aerosols play a basic role in soil composition and processes, including the production of essential plant nutrients through weathering. Although the long-term role of dust in the development of soils is reasonably well understood, the effects of recent dust emission and deposition on ecosystems are not. Recent work on ecosystems around the world has highlighted the fundamental importance of contemporary wind erosion and dust deposition in biogeochemical cycling. In the western U.S., studies of Sr and Nd isotopes, elemental concentrations, and magnetic properties elucidate the role of dust in recent soil development and soil loss by wind erosion related to land-use change. In the arid landscapes in and around Canyonlands National Park (Utah), these techniques provide insight into the development of soils in stable settings where human activities have been minimal but the loss of soil in areas affected by grazing and recreational activities. In stable settings of the central Colorado Plateau (Utah), dust deposition is responsible for a large proportion (as much as 20 percent) of surface soil mass and elemental content. In contrast, wind erosion is responsible for large losses of nutrients and surface soil of nearby, closely similar geomorphic settings disturbed by human activity. In the San Juan Mountains (Colorado) downwind of the Colorado Plateau, Nd and Sr isotopes in dust and lake sediments provide evidence for large increases in dust deposition during the 19th and 20th century compared to records from the middle to late Holocene. The recent enhancement in dust deposition is also responsible for increased loading of many elements, including essential nutrients that may influence

  20. Driver’s Awareness and Lane Changing Maneuver in Traffic Flow based on Cellular Automaton Model

    OpenAIRE

    Kohei Arai; Steven Ray Sentinuwo

    2015-01-01

    Effect of driver’s awareness (e.g., to estimate the speed and arrival time of another vehicle) on the lane changing maneuver is discussed. “Scope awareness” is defined as the visibility which is required for the driver to make a visual perception about road condition and the speed of vehicle that appears in the target lane for lane changing in the road. Cellular automaton based simulation model is created and applied to simulation studies for driver awareness behavior. This study clarifies re...

  1. Operating the railway traffic control system

    Directory of Open Access Journals (Sweden)

    Anton PEPEVNIK

    2011-01-01

    Full Text Available Due to the valid traffic policy and development strategy of the Republic of Slovenia, the Slovenian Railways have to consider the developmental and strategic aims of European railways. The perspective of progress is basically determined by skimming the European system development, by taking over the European system and managing the railway traffic in the connection with the European railway system.Technology and organization of the railway traffic system present the sum of all technological and organizational elements and processes that takes part in providing aims of the system. The aims are defined as solving transport problems in railway system. The term system is defined, from the formal mathematical viewpoint, as a whole that is usually complicated or even very much complicated. Therefore, the railway system is complex as well, and that is why it has to be managed precisely. In the narrow sense of meaning, technology and work organization both comprises a variety of means and procedures to realize basic activity that can be seen as a perfect unit, and that can be the process of passengers and freight transport in a transport system.Because of the prompt development of microelectronics and computer engineering, a new generation of electronic signal-safety devices appeared.All these changes from the past few years that have been introduced into railway technology, enable railway to become attractive and competitive to other means of traffic. Therefore, the Slovenian Railways have to follow novelties in traffic technology development and gradually modernize its railway network.

  2. Transient carbon isotope changes in complex systems: Finding the global signal, embracing the local signal

    Science.gov (United States)

    Bowen, G. J.; Schneider-Mor, A.; Filley, T. R.

    2008-12-01

    Global, transient carbon isotope excursions (CIEs) in the geological record are increasingly invoked as evidence of short-lived changes in carbon fluxes to/from the ocean-atmosphere-biosphere (exogenic) system. Reconstructing the dynamics of carbon cycle perturbation and response during such events requires that the global extent, magnitude, and temporal pattern of carbon isotope change are well understood. Unfortunately, no simple, globally integrated measure of exogenic δ13C change exists in the geological record: during major global perturbations even the best-case candidates such as deep-ocean carbonate δ13C values likely respond to a complex of factors including ocean carbonate chemistry and circulation. Here we consider the utility of organic carbon isotope records from two complex depositional systems common in the geological record, fossil soils and continental margin sediments, which are of interest in terms of their relationship to organic carbon cycling and records of past ecological change. Within both systems changes in ecology, climate, carbon source, residence time, and molecular composition have clear potential to modulate the preserved record of global exogenic δ13C change, compromising 1st-order interpretations of bulk or compound-specific isotopic records. Process-explicit eco- geochemical models, ideally combined with multi-substrate data, provide one approach to the isolation of global δ13C change and identification of local or regional processes reflected in such records. Examples from both systems drawn from ongoing work on the Paleocene-Eocene thermal maximum illustrate the potential pitfalls, as well as opportunities, afforded by coupled data/model assessment of transient δ13C changes in complex systems.

  3. Palaeoenvironmental changes during the Danian-Selandian boundary interval: The ichnological record at the Sopelana section (Basque Basin, W Pyrenees)

    Science.gov (United States)

    Rodríguez-Tovar, F. J.; Uchman, A.; Orue-Etxebarria, X.; Apellaniz, E.

    2013-02-01

    Ichnological analysis was conducted in the Danian-Selandian (D-S) boundary interval from the Sopelana section (Basque Basin, northern Spain) to improve characterization of the recently defined Global Stratotype Section and Point of the base of the Selandian Stage (Middle Paleocene) in the nearby Zumaia section, and to interpret the Danian-Selandian boundary event with its associated palaeoenvironmental changes. The trace fossil assemblage of the boundary interval is relatively scarce and shows low diversity, consisting of Chondrites, Planolites, Thalassinoides, Trichichnus and Zoophycos, which cross-cut a diffuse, burrow-mottled background, typical of a normal burrowing tiered community. Distribution of trace fossils shows local drops in abundance and diversity just above the D-S boundary and about half a metre upwards into the succeeding Selandian. Generally, the Selandian part of the section has slightly lower trace fossil diversity and abundance. This is interpreted as due to a higher detrital food supply, corresponding to a sea-level fall, in contrast to a decreased food supply during the Selandian sea-level rise. Smaller-scale fluctuations of trace fossil diversity and abundance are also interpreted as due more to food content fluctuations in the sediment than to oxygenation of pore waters. Results reveal the minor influence of an extreme warming event (hyperthermal conditions) at the D-S boundary which affected the whole benthic habitat. Contrarily, a probable major effect of sea-level fluctuations can be envisaged, which determined variations in siliciclastic input and food content.

  4. Models for Predictive Railway Traffic Management

    OpenAIRE

    Kecman, P.

    2014-01-01

    The potential growth in transport demand in the next decade and beyond requires a change from reactive to proactive traffic control to maintain and improve the reliability of railway traffic. In order to enable an anticipative approach to traffic management, it is necessary to develop the tools for monitoring, prediction and optimisation of the traffic operations. This thesis presents the models that can be used as components for a decision support system for predictive traffic management.

  5. Changes of the cell cycle regulators and cell cycle arrest in cervical cancer cells after cisplatin therapy

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Objective To investigate the changes of the cell cycle regulators ATM,Chk2 and p53 and cell cycle arrest in HeLa cells after cisplatin therapy. Methods The proliferation-inhibiting rates of HeLa cells induced by cisplatin of different concentrations were measured by MTT assays. The mRNA and protein expressions of ATM,Chk2 and p53 of HeLa cells with and without cisplatin were detected by RT-PCR and Western blot,respectively. The cell cycle analysis was conducted by flow cytometric analysis. Results Cisplatin...

  6. The Effect of High-Intensity Interval Cycling Sprints Subsequent to Arm-Curl Exercise on Upper-Body Muscle Strength and Hypertrophy.

    Science.gov (United States)

    Kikuchi, Naoki; Yoshida, Shou; Okuyama, Mizuki; Nakazato, Koichi

    2016-08-01

    Kikuchi, N, Yoshida, S, Okuyama, M, and Nakazato, K. The effect of high-intensity interval cycling sprints subsequent to arm-curl exercise on upper-body muscle strength and hypertrophy. J Strength Cond Res 30(8): 2318-2323, 2016-The purpose of this study was to examine whether lower limb sprint interval training (SIT) after arm resistance training (RT) influences training response of arm muscle strength and hypertrophy. Twenty men participated in this study. We divided subjects into RT group (n = 6) and concurrent training group (CT, n = 6). The RT program was designed to induce muscular hypertrophy (3 sets × 10 repetitions [reps] at 80% 1 repetition maximum [1RM] of arm-curl exercise) and was performed in an 8-week training schedule performed 3 times per week on nonconsecutive days. Subjects assigned to the CT group performed identical protocols as strength training and modified SIT (4 sets of 30-s maximal effort, separated in 4 m 30-s rest intervals) on the same day. Pretest and posttest maximal oxygen consumption (V[Combining Dot Above]O2max), muscle cross-sectional area (CSA), and 1RM were measured. Significant increase in V[Combining Dot Above]O2max from pretest to posttest was observed in the CT group (p = 0.010, effect size [ES] = 1.84) but not in the RT group (p = 0.559, ES = 0.35). Significant increase in CSA from pretest to posttest was observed in the RT group (p = 0.030, ES = 1.49) but not in the CT group (p = 0.110, ES = 1.01). Significant increase in 1RM from pretest to posttest was observed in the RT group (p = 0.021, ES = 1.57) but not in the CT group (p = 0.065, ES = 1.19). In conclusion, our data indicate that concurrent lower limb SIT interferes with arm muscle hypertrophy and strength. PMID:26694501

  7. Accidentes de tránsito de vehículos de motor en la población joven: evaluación de una intervención educativa en Cuernavaca, Morelos Road traffic injuries among youth: measuring the impact of an educational intervention

    Directory of Open Access Journals (Sweden)

    Elisa Hidalgo-Solórzano

    2008-01-01

    Full Text Available OBJETIVO: Analizar el efecto de una intervención educativa dirigida a incrementar el conocimiento sobre causas y factores de riesgo de accidentes de tránsito de vehículos de motor (ATVM en jóvenes de la ciudad de Cuernavaca. MATERIAL Y MÉTODOS: Se utilizó un diseño cuasi-experimental en estudiantes de 15 a 19 años inscritos en preparatorias y universidades. La intervención educativa incluyó mensajes de radio, trípticos, pendones, carteles y tarjetas postales. La medida del efecto se estableció en los cambios en el conocimiento de factores de riesgo: velocidad, alcohol y uso de cinturón de seguridad, con base en la metodología de análisis factorial. RESULTADOS: Se observó un cambio significativo en el nivel de conocimiento (p=0.000 en 700 alumnos de 16 planteles educativos. CONCLUSIONES: Las intervenciones educativas representan un primer grupo de medidas para lograr cambios de conocimiento y conducta poblacionales. El presente estudio aporta una metodología para medir a corto plazo los cambios en el conocimiento sobre riesgos relacionados con el principal problema que afecta a los jóvenes mexicanos.OBJECTIVE: To analyze the impact of an educative intervention intended to increase the knowledge of causes and risk factors associated with road traffic iinjries in the city of Cuernavaca. MATERIAL AND METHODS: A quasi-experimental study design was administered to students from 16 to 19 years old in colleges and universities in the city of Cuernavaca. The educative intervention included radio spots, banners, pamphlets, posters and cards. The measure of impact was established as changes in knowledge about speed, alcohol and the use of seat belts, using factor analysis methodologies. RESULTS: A significant change in the level of knowledge (p= 0.000 was observed in 700 students from 16 institutions. CONCLUSIONS: Educative interventions represent an initial strategy for changes in knowledge and population behaviours. The present study

  8. Improvement spatial resolution of frequency modulated continuous wave laser ranging system by splicing equal optical frequency interval sampled signal

    Science.gov (United States)

    Shi, Guang; Zhang, Fumin; Qu, Xinghua

    2015-02-01

    A dual interferometry FMCW laser ranging system is presented. The auxiliary interferometer for generating the clock pulses at equally spaced optical frequencies is incorporated into the main interferometer to simplify the system configuration and to compensate the tuning linearity of the laser source. The need of widely tunable laser limits the practical application of the FMCW laser ranging for precision industrial measurement. Splicing sampled signal method is proposed to break though the tuning range of the laser source limitation against the special resolution. In the experiments, 50 μm range resolution at 8.7 m is demonstrated, and this resolution is maintained over the entire measuring range. The measuring range depending on the power and coherence length of the source can reach more than 20 m. The system structure is simple, and the requirement on the tuning range of laser source is reduced in this system.

  9. Experimental Design for Stochastic Models of Nonlinear Signaling Pathways Using an Interval-Wise Linear Noise Approximation and State Estimation

    Science.gov (United States)

    Zimmer, Christoph

    2016-01-01

    Background Computational modeling is a key technique for analyzing models in systems biology. There are well established methods for the estimation of the kinetic parameters in models of ordinary differential equations (ODE). Experimental design techniques aim at devising experiments that maximize the information encoded in the data. For ODE models there are well established approaches for experimental design and even software tools. However, data from single cell experiments on signaling pathways in systems biology often shows intrinsic stochastic effects prompting the development of specialized methods. While simulation methods have been developed for decades and parameter estimation has been targeted for the last years, only very few articles focus on experimental design for stochastic models. Methods The Fisher information matrix is the central measure for experimental design as it evaluates the information an experiment provides for parameter estimation. This article suggest an approach to calculate a Fisher information matrix for models containing intrinsic stochasticity and high nonlinearity. The approach makes use of a recently suggested multiple shooting for stochastic systems (MSS) objective function. The Fisher information matrix is calculated by evaluating pseudo data with the MSS technique. Results The performance of the approach is evaluated with simulation studies on an Immigration-Death, a Lotka-Volterra, and a Calcium oscillation model. The Calcium oscillation model is a particularly appropriate case study as it contains the challenges inherent to signaling pathways: high nonlinearity, intrinsic stochasticity, a qualitatively different behavior from an ODE solution, and partial observability. The computational speed of the MSS approach for the Fisher information matrix allows for an application in realistic size models. PMID:27583802

  10. Changes in genetic selection differentials and generation intervals in US Holstein dairy cattle as a result of genomic selection.

    Science.gov (United States)

    García-Ruiz, Adriana; Cole, John B; VanRaden, Paul M; Wiggans, George R; Ruiz-López, Felipe J; Van Tassell, Curtis P

    2016-07-12

    Seven years after the introduction of genomic selection in the United States, it is now possible to evaluate the impact of this technology on the population. Selection differential(s) (SD) and generation interval(s) (GI) were characterized in a four-path selection model that included sire(s) of bulls (SB), sire(s) of cows (SC), dam(s) of bulls (DB), and dam(s) of cows (DC). Changes in SD over time were estimated for milk, fat, and protein yield; somatic cell score (SCS); productive life (PL); and daughter pregnancy rate (DPR) for the Holstein breed. In the period following implementation of genomic selection, dramatic reductions were seen in GI, especially the SB and SC paths. The SB GI reduced from ∼7 y to less than 2.5 y, and the DB GI fell from about 4 y to nearly 2.5 y. SD were relatively stable for yield traits, although modest gains were noted in recent years. The most dramatic response to genomic selection was observed for the lowly heritable traits DPR, PL, and SCS. Genetic trends changed from close to zero to large and favorable, resulting in rapid genetic improvement in fertility, lifespan, and health in a breed where these traits eroded over time. These results clearly demonstrate the positive impact of genomic selection in US dairy cattle, even though this technology has only been in use for a short time. Based on the four-path selection model, rates of genetic gain per year increased from ∼50-100% for yield traits and from threefold to fourfold for lowly heritable traits. PMID:27354521

  11. Programming with Intervals

    Science.gov (United States)

    Matsakis, Nicholas D.; Gross, Thomas R.

    Intervals are a new, higher-level primitive for parallel programming with which programmers directly construct the program schedule. Programs using intervals can be statically analyzed to ensure that they do not deadlock or contain data races. In this paper, we demonstrate the flexibility of intervals by showing how to use them to emulate common parallel control-flow constructs like barriers and signals, as well as higher-level patterns such as bounded-buffer producer-consumer. We have implemented intervals as a publicly available library for Java and Scala.

  12. Traffic Monitor

    Science.gov (United States)

    1992-01-01

    Mestech's X-15 "Eye in the Sky," a traffic monitoring system, incorporates NASA imaging and robotic vision technology. A camera or "sensor box" is mounted in a housing. The sensor detects vehicles approaching an intersection and sends the information to a computer, which controls the traffic light according to the traffic rate. Jet Propulsion Laboratory technical support packages aided in the company's development of the system. The X-15's "smart highway" can also be used to count vehicles on a highway and compute the number in each lane and their speeds, important information for freeway control engineers. Additional applications are in airport and railroad operations. The system is intended to replace loop-type traffic detectors.

  13. Cycling excitation process: An ultra efficient and quiet signal amplification mechanism in semiconductor

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yu-Hsin [Materials Science and Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0418 (United States); Yan, Lujiang; Zhang, Alex Ce; Hall, David; Niaz, Iftikhar Ahmad; Zhou, Yuchun [Department of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0409 (United States); Sham, L. J. [Department of Physics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 (United States); Lo, Yu-Hwa, E-mail: ylo@ucsd.edu [Materials Science and Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0418 (United States); Department of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0409 (United States)

    2015-08-03

    Signal amplification, performed by transistor amplifiers with its merit rated by the efficiency and noise characteristics, is ubiquitous in all electronic systems. Because of transistor thermal noise, an intrinsic signal amplification mechanism, impact ionization was sought after to complement the limits of transistor amplifiers. However, due to the high operation voltage (30-200 V typically), low power efficiency, limited scalability, and, above all, rapidly increasing excess noise with amplification factor, impact ionization has been out of favor for most electronic systems except for a few applications such as avalanche photodetectors and single-photon Geiger detectors. Here, we report an internal signal amplification mechanism based on the principle of the phonon-assisted cycling excitation process (CEP). Si devices using this concept show ultrahigh gain, low operation voltage, CMOS compatibility, and, above all, quantum limit noise performance that is 30 times lower than devices using impact ionization. Established on a unique physical effect of attractive properties, CEP-based devices can potentially revolutionize the fields of semiconductor electronics.

  14. Cycling excitation process: An ultra efficient and quiet signal amplification mechanism in semiconductor

    International Nuclear Information System (INIS)

    Signal amplification, performed by transistor amplifiers with its merit rated by the efficiency and noise characteristics, is ubiquitous in all electronic systems. Because of transistor thermal noise, an intrinsic signal amplification mechanism, impact ionization was sought after to complement the limits of transistor amplifiers. However, due to the high operation voltage (30-200 V typically), low power efficiency, limited scalability, and, above all, rapidly increasing excess noise with amplification factor, impact ionization has been out of favor for most electronic systems except for a few applications such as avalanche photodetectors and single-photon Geiger detectors. Here, we report an internal signal amplification mechanism based on the principle of the phonon-assisted cycling excitation process (CEP). Si devices using this concept show ultrahigh gain, low operation voltage, CMOS compatibility, and, above all, quantum limit noise performance that is 30 times lower than devices using impact ionization. Established on a unique physical effect of attractive properties, CEP-based devices can potentially revolutionize the fields of semiconductor electronics

  15. The cycle-dependence of Far-UV and Middle-UV solar emission: EMD analysis of SOLSTICE and Mg II signals

    Science.gov (United States)

    Berrilli, Francesco; Lovric, Mija; Federico, Tosone; Cagnazzo, Chiara; Del Moro, Dario; Pietropaolo, Ermanno

    2016-04-01

    The solar Far-UV and Middle-UV variability is extremely relevant for the stratospheric ozone concentration and dynamics. We investigate solar UV variability at decennial time scale using the data of SOLar-STellar Irradiance Comparison Experiment (SOLSTICE) on SORCE and Bremen Mg II composite signal. The Empirical Mode Decomposition (EMD) technique has been applied to Mg II and UV signals to separate intrinsic solar components and focus on 11-y variability. The analysis shows that the star changes the UV spectral distribution during 11-y cycle with a different behaviour during the descending phase of cycle 23 and growing phase of cycle 24. The observed UV major evolution can provide empirically-motivated UV predictions over the cycles. On the other hand, the observed minor differences during the ascending and descending phase of solar cycle can be attributed to physical changes in solar emission or described by an uncorrected time-dependent performance of SOLSTICE UV channels. We shortly discuss both possibilities.

  16. Posture-related changes in brain functional connectivity as assessed by wavelet phase coherence of NIRS signals in elderly subjects.

    Science.gov (United States)

    Wang, Bitan; Zhang, Ming; Bu, Lingguo; Xu, Liwei; Wang, Wei; Li, Zengyong

    2016-10-01

    Postural instability and falls are commonly seen because of aging and motor disabilities. This study aims to assess the posture-related changes in brain functional connectivity by wavelet phase coherence (WPCO) of oxyhemoglobin concentration change (Δ[HbO2]) signals measured through near-infrared spectroscopy (NIRS) in elderly subjects. The NIRS signals were continuously recorded from the prefrontal cortex and sensorimotor cortical areas in 39 healthy elderly subjects and 22 young healthy subjects during 20min resting and 10min standing states. Eight connection types were obtained from the recorded brain areas. The WPCO were calculated in five frequency intervals in each channel pair as follows: I, 0.6-2Hz; II, 0.145-0.6Hz; III, 0.052-0.145Hz; IV, 0.021-0.052Hz; and V, 0.0095-0.021Hz. Results show that posture change and age significantly interacts with the right prefrontal cortex (PFC) and left sensorimotor cortex (SMC) connectivity in interval V (F=5.010, p=0.028). The left and right PFC connectivity in interval I, the left and right SMC connectivity in interval IV, and the connectivity in interval V, including right PFC and right SMC connectivity, left PFC and left SMC connectivity, and right PFC and left SMC connectivity, showed a significant difference between the Group Elderly and Group Young in response to posture change (p<0.05). This study provides new insight into the mechanism of posture control, and results may be useful in assessing the risk of postural instability in aged persons. PMID:27335218

  17. Automatic and efficient driving strategies while approaching a traffic light

    CERN Document Server

    Treiber, Martin

    2014-01-01

    Vehicle-infrastructure communication opens up new ways to improve traffic flow efficiency at signalized intersections. In this study, we assume that equipped vehicles can obtain information about switching times of relevant traffic lights in advance. This information is used to improve traffic flow by the strategies 'early braking', 'anticipative start', and 'flying start'. The strategies can be implemented in driver-information mode, or in automatic mode by an Adaptive Cruise Controller (ACC). Quality criteria include cycle-averaged capacity, driving comfort, fuel consumption, travel time, and the number of stops. By means of simulation, we investigate the isolated strategies and the complex interactions between the strategies and between equipped and non-equipped vehicles. As universal approach to assess equipment level effects we propose relative performance indexes and found, at a maximum speed of 50 km/h, improvements of about 15% for the number of stops and about 4% for the other criteria. All figures d...

  18. Atypical MR lenticular signal change in infantile isovaleric acidemia.

    Science.gov (United States)

    Wani, Nisar A; Qureshi, Umer Amin; Jehangir, Majid; Ahmad, Kaiser; Hussain, Zahid

    2016-01-01

    Isovaleric acidemia (IVA) is an inborn error of branched chain amino acid metabolism that may manifest as acute neonatal metabolic acidosis or as chronic intermittent form with developmental delay or recurrent episodes of acute metabolic acidosis. Early diagnosis is the key to prevent morbidity and mortality. Brain imaging abnormalities are rarely described in IVA. We report a case of chronic intermittent IVA with acute presentation in a 4-month-old infant who presented with acute metabolic acidosis. Brain magnetic resonance imaging (MRI) revealed symmetric signal intensity changes in bilateral lentiform nuclei with an unreported T1-weighted (T1W) symmetric hyperintense ring-like appearance in bilateral putamen. PMID:27081237

  19. Describe the Historical Changes of Yunnan Traffic Culture%试述云南交通文化的历史变迁

    Institute of Scientific and Technical Information of China (English)

    彭云

    2013-01-01

    通过对云南古代、近现代、建国后、改革开放后到云南作为中国连接东南亚、南亚、“桥头堡-大通道”等各个历史时期,云南交通发展及交通文化特点内容的阐述,分析了云南交通文化各历史阶段的发展变迁特点,以期云南交通文化在不断传承发展过程中,进一步丰富内涵和拓展外延。%Through expounding the contents of Yunnan traffic development and traffic cultural characteristics in the different historical periods of Yunnan ancient and modern times ,after the founding of new China ,the reforming and o-pening to the time of Yunnan as the connecting Southeast Asia ,South Asia ,“bridgehead-channel” and so on ,the paper analyzes the developing and changing characteristics in the different historical stages of Yunnan traffic culture in order to hope Yunnan traffic culture inheritance in constant development process ,further enrich the connotation and expand the extension .

  20. Changes in QTc interval in the citalopram for agitation in Alzheimer's disease (CitAD randomized trial.

    Directory of Open Access Journals (Sweden)

    Lea T Drye

    Full Text Available A Food and Drug Administration (FDA safety communication in August 2011 warned that citalopram was associated with a dose dependent risk of QT prolongation and recommended dose restriction in patients over the age of 60 but did not provide data for this age group.CitAD was a randomized, double-masked, placebo-controlled, multicenter clinical trial for agitation in Alzheimer's disease (AD. Participants were assigned to citalopram (target dose of 30 mg/day or placebo in a 1 ∶ 1 ratio. 186 people, 181 of whom were over the age of 60, having probable AD with clinically significant agitation were recruited from September 2009 to January 2013. After the FDA safety communication about citalopram, ECG was added to the required study procedures before enrollment and repeated at week 3 to monitor change in QTc interval. Forty-eight participants were enrolled after enhanced monitoring began.Citalopram treatment was associated with a larger increase in QTc interval than placebo (difference in week 3 QTc adjusting for baseline QTc: 18.1 ms [95% CI: 6.1, 30.1]; p = 0.004. More participants in the citalopram group had an increase ≥ 30 ms from baseline to week 3 (7 in citalopram versus 1 in placebo; Fisher's exact p = 0.046, but only slightly more in the citalopram group met a gender-specific threshold for prolonged QTc (450 ms for males; 470 ms for females at any point during follow-up (3 in citalopram versus 1 in placebo, Fisher's exact p = 0.611. One of the citalopram participants who developed prolonged QTc also displayed ventricular bigeminy. No participants in either group had a cardiovascular-related death.Citalopram at 30 mg/day was associated with improvement in agitation in patients with AD but was also associated with QT prolongation.ClinicalTrials.gov NCT00898807.

  1. Self——adaptive Control Method for Traffic Signal at Single Intersection Based on Cloud Model Adaptive%基于云模型的单路口交通信号自适应控制方法研究

    Institute of Scientific and Technical Information of China (English)

    刘罗仁; 罗金玲

    2011-01-01

    为了减少车辆通过路口的延误,提出了一种基于云模型的单路口交通信号自适应控制方法;使用云模型作为信号控制的基础模型,利用云模型中的正态云发生器和前件云发生器算法分别对道路交通信息进行处理并产生自适应的控制规则,以实现单路口交通信号的自适应控制;通过仿真实验,结果表明,使用云模型作为控制方法,比较传统控制方式更具智能化,更接近于人脑思维过程的控制方法,这也是将来交通信号控制的发展方向.%In order to reduce traffic delays through the intersection, this paper presents, a single intersection based on cloud model adaptive traffic signal control. Signal control using the cloud model as the basis model, the cloud model in the normal cloud generator and the former pieces of cloud generator algorithms are processed on road traffic information and generates adaptive control rules in order to achieve a single self-intersection traffic signal adaptive control. The simulation experiment results show that the control method using the cloud model as the more traditional control method is more intelligent, more close to the brain control the process of thinking, this is the future direction of development of traffic signal control.

  2. Isothermal cycling and cascade signal amplification strategy for ultrasensitive colorimetric detection of nucleic acids

    International Nuclear Information System (INIS)

    We have designed a novel isothermal cascade signal-amplification strategy for ultrasensitive colorimetric determination of nucleic acids. It is based on double-cycling amplification with formation of DNAzyme via a polymerase-induced strand-displacement reaction and nicking endonuclease-assisted recycling. The assay makes use of a hairpin DNA, a short primer, KF-polymerase, and nicking endonuclease. The presence of a target DNA triggers the strand-displacement and polymerization reaction with the formation of numerous DNAzyme molecules. Upon addition of H2O2 to the resulting mixture, the H2O2 reacts with 2,2′-azino-bis (3-ethylbenzothiozoline)-6-sulfonate to form a colored product in the aid of DNAzyme, which is quantified by photometry at 415 nm. Under optimal conditions, the assay allows target DNA to be determined at concentration as low as 0.6 aM. (author)

  3. Noise and critical phenomena in biochemical signaling cycles at small molecule numbers

    Science.gov (United States)

    Metzner, C.; Sajitz-Hermstein, M.; Schmidberger, M.; Fabry, B.

    2009-08-01

    Biochemical reaction networks in living cells usually involve reversible covalent modification of signaling molecules, such as protein phosphorylation. Under conditions of small molecule numbers, as is frequently the case in living cells, mass-action theory fails to describe the dynamics of such systems. Instead, the biochemical reactions must be treated as stochastic processes that intrinsically generate concentration fluctuations of the chemicals. We investigate the stochastic reaction kinetics of covalent modification cycles (CMCs) by analytical modeling and numerically exact Monte Carlo simulation of the temporally fluctuating concentration. Depending on the parameter regime, we find for the probability density of the concentration qualitatively distinct classes of distribution functions including power-law distributions with a fractional and tunable exponent. These findings challenge the traditional view of biochemical control networks as deterministic computational systems and suggest that CMCs in cells can function as versatile and tunable noise generators.

  4. CHANGES IN VALUES MEASURED WITH DIAGNOdent FOR ENAMEL AND DENTIN OF DECIDUOUS TEETH ETCHED FOR DIFFERENT TIME INTERVALS.

    Directory of Open Access Journals (Sweden)

    Vladimir E. Panov

    2014-09-01

    Full Text Available Introduction: Dental caries continues to affect a large percentage of children and currently advises that if diagnosed at an early stage can be reversed with minimally invasive treatments. There a large number of methods for early diagnostics. Purpose: The aim of the presented in vitro study was to evaluate the effectiveness of the laser fluorescent device DIAGNOdent pen in measuring changes in the level of mineralization of intact deciduous teeth enamel surfaces etched for different intervals and of intact dentin etched for 30 seconds. Material and methods: The study was performed on extracted children teeth. DIAGNOdent was used to measure the values of laser fluorescence of intact enamel and dentinal surfaces. Samples were treated with 37% H2PO3 etched for 5 sec., 30 sec. and 60 sec. for enamel surfaces and 30 sec. for dentinal. Teeth were rinsed, dried and measured again with DIAGNOdent. Results: After etching the enamel surfaces for 5 sec., 30 sec. and 60 sec. an average increase of 1.55 (0.85-2.2 was detected. The detected average values of increase of laser fluorescence for the enamel were 0.85 for 5 sec. ethching; 1.6 for 30 sec. and 2.2 for 60 sec. The average increase in the dentine was 3.5. Conclusions: Based on the limitations of the conducted study it may be concluded that the changes in the degree of mineralization of deciduous tooth structures can be detected by DIAGNOdent. Enamel etching for 5 sec., 30 sec. and 60 sec. lead to a comparative degree of change in the laser fluorescence. The obtained values after 30 sec. of etching revealed almost a double increase compared to 5 sec. etching and 3-fold for those at the 60 sec. The measured changes after etching in the dentin were better expressed than those in the enamel.

  5. CHANGES IN VALUES MEASURED WITH A LASER FLUORESCENCE SYSTEM FOR ENAMEL AND DENTIN ETHCED FOR DIFFERNT TIME INTERVALS - pilot study.

    Directory of Open Access Journals (Sweden)

    Radostina Anastasova

    2014-06-01

    Full Text Available Purpose: The aim of the presented in vitro study was to evaluate the effectiveness of the laser fluorescent device DIAGNOdent in measuring changes in the level of mineralization of intact enamel surfaces etched for different time intervals and intact dentin etched for 30 sec. Material and methods: The study was performed on extracted human teeth. DIAGNOcam was used to measure the values of laser fluorescence of intact enamel and dentinal surfaces. Then the samples were treated with 37% H2PO3 etchant for 5, 30 and 60 sec for enamel surfaces and 30 sec for dentinal. Teeth were rinsed, dried and measured again with DIAGNOdent. Statistical analysis was done using statistical software SPSS 16.0 (SPSS Inc.. Results: After etching the enamel surfaces for 5, 30 and 60 seconds an average increase of 0,5 (0.62-1.1 was detected. The detected average values of increase of laser fluorescence for the enamel were 0.5 for 5 sec. ethching, 0.62 for 30 sec and 1.1 for 60 sec. The average increase for dentine was 0.26. Conclusions: Based on the limitations of the conducted study it may be concluded that changes in the degree of mineralization of tooth structures can be detected by using DIAGNOdent. Enamel etching for 5 sec and 30 sec lead to a comparative degree of change in the laser fluorescence. The obtained values after 60 sec. of etching revealed an almost double increase. The measured changes in enamel after etching are better pronounced than that in dentin.

  6. Sexual desire changes during menstrual cycle and relationship with premenstrual syndrome

    OpenAIRE

    Kiani Asiabar A.; Heidari M; Mohammady Tabar SH.; Faghihzadeh S

    2007-01-01

    Background: Sexual function in women may be affected by their menstrual cycle. Lack of sexual drive is a deficiency or absence of sexual fantasies and desire for sexual activity. This study aims at determining the changes in sexual desire during the menstrual cycle and those associated with premenstrual syndrome (PMS) and evaluates sexual desire during the menstrual cycle and the associated changes with PMS. Methods: The sample for this cross-sectional study includes 150 women employed in fac...

  7. Life-cycle stages, mobility, and metropolitan change: 1. Theoretcal issues

    OpenAIRE

    M J Webber

    1983-01-01

    It is shown how one dynamic element may be incorporated into operational urban models. That element is household mobility, caused by the evolution of households through stages in the life cycle. First, the significance of life-cycle changes as an agent causing intraurban mobility is reviewed; next, a matrix representation of the dynamics of life-cycle changes is examined; and then the properties of that representation are described.

  8. Study of dimensional changes during redox cycling of oxygen carrier materials for chemical looping combustion

    NARCIS (Netherlands)

    Fossdal, A.; Darell, O.; Lambert, A.; Schols, E.; Comte, E.; Leenman, R.N.; Blom, R.

    2015-01-01

    Dimensional and phase changes of four candidate oxygen carrier materials for chemical looping combustion are investigated by dilatometry and high-temperature X-ray diffraction during four redox cycles. NiO/Ni2AlO4 does not exhibit significant dimensional changes during cycling, and it is shown that

  9. Wavelet Transform Analysis of the Power Spectrum of Centre of Pressure Signals to Detect the Critical Point Interval of Postural Control

    Science.gov (United States)

    Singh, Neeraj Kumar; Snoussi, Hichem; Hewson, David; Duchêne, Jacques

    The aim of this study was to develop a method to detecting the critical point interval (CPI) when sensory feedback is used as part of a closed-loop postural control strategy. Postural balance was evaluated using centre of pressure (COP) displacements from a force plate for 17 control and 10 elderly subjects under eyes open, eyes closed, and vibration conditions. A modified local-maximum-modulus wavelet transform analysis using the power spectrum of COP signals was used to calculate CPI. Lower CPI values indicate increased closed-loop postural control with a quicker response to sensory input. Such a strategy requires greater energy expenditure due to the repeated muscular interventions to remain stable. The CPI for elderly occurred significantly quicker than for controls, indicating tighter control of posture. Similar results were observed for eyes closed and vibration conditions. The CPI parameter can be used to detect differences in postural control due to ageing.

  10. Calcium signaling and T-type calcium channels in cancer cell cycling

    Institute of Scientific and Technical Information of China (English)

    James T Taylor; Xiang-Bin Zeng; Jonathan E Pottle; Kevin Lee; Alun R Wang; Stephenie G Yi; Jennifer A S Scruggs; Suresh S Sikka; Ming Li

    2008-01-01

    Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells,free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear;however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers.

  11. SPARC expression induces cell cycle arrest via STAT3 signaling pathway in medulloblastoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Chetty, Chandramu [Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL-61605 (United States); Dontula, Ranadheer [Section of Hematology/Oncology, Department of Medicine, University of Illinois College of Medicine at Chicago, 840 South Wood Street, Suite 820-E, Chicago, IL-60612 (United States); Ganji, Purnachandra Nagaraju [Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL-61605 (United States); Gujrati, Meena [Department of Pathology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL-61605 (United States); Lakka, Sajani S., E-mail: slakka@uic.edu [Section of Hematology/Oncology, Department of Medicine, University of Illinois College of Medicine at Chicago, 840 South Wood Street, Suite 820-E, Chicago, IL-60612 (United States)

    2012-01-13

    Highlights: Black-Right-Pointing-Pointer Ectopic expression of SPARC impaired cell proliferation in medulloblastoma cells. Black-Right-Pointing-Pointer SPARC expression induces STAT3 mediated cell cycle arrest in medulloblastoma cells. Black-Right-Pointing-Pointer SPARC expression significantly inhibited pre-established tumor growth in nude-mice. -- Abstract: Dynamic cell interaction with ECM components has profound influence in cancer progression. SPARC is a component of the ECM, impairs the proliferation of different cell types and modulates tumor cell aggressive features. We previously reported that SPARC expression significantly impairs medulloblastoma tumor growth in vivo. In this study, we demonstrate that expression of SPARC inhibits medulloblastoma cell proliferation. MTT assay indicated a dose-dependent reduction in tumor cell proliferation in adenoviral mediated expression of SPARC full length cDNA (Ad-DsRed-SP) in D425 and UW228 cells. Flow cytometric analysis showed that Ad-DsRed-SP-infected cells accumulate in the G2/M phase of cell cycle. Further, immunoblot and immunoprecipitation analyses revealed that SPARC induced G2/M cell cycle arrest was mediated through inhibition of the Cyclin-B-regulated signaling pathway involving p21 and Cdc2 expression. Additionally, expression of SPARC decreased STAT3 phosphorylation at Tyr-705; constitutively active STAT3 expression reversed SPARC induced G2/M arrest. Ad-DsRed-SP significantly inhibited the pre-established orthotopic tumor growth and tumor volume in nude-mice. Immunohistochemical analysis of tumor sections from mice treated with Ad-DsRed-SP showed decreased immunoreactivity for pSTAT3 and increased immunoreactivity for p21 compared to tumor section from mice treated with mock and Ad-DsRed. Taken together our studies further reveal that STAT3 plays a key role in SPARC induced G2/M arrest in medulloblastoma cells. These new findings provide a molecular basis for the mechanistic understanding of the

  12. Bound Maxima as a Traffic Feature under DDOS Flood Attacks

    Directory of Open Access Journals (Sweden)

    Jie Xue

    2012-01-01

    Full Text Available This paper gives a novel traffic feature for identifying abnormal variation of traffic under DDOS flood attacks. It is the histogram of the maxima of the bounded traffic rate on an interval-by-interval basis. We use it to experiment on the traffic data provided by MIT Lincoln Laboratory under Defense Advanced Research Projects Agency (DARPA in 1999. The experimental results profitably enhance the evidences that traffic rate under DDOS attacks is statistically higher than that of normal traffic considerably. They show that the pattern of the histogram of the maxima of bounded rate of attack-contained traffic greatly differs from that of attack-free traffic. Besides, the present traffic feature is simple in mathematics and easy to use in practice.

  13. The Effect of Total Cumulative Dose, Number of Treatment Cycles, Interval between Injections, and Length of Treatment on the Frequency of Occurrence of Antibodies to Botulinum Toxin Type A in the Treatment of Muscle Spasticity

    Science.gov (United States)

    Bakheit, Abdel Magid O.; Liptrot, Anthea; Newton, Rachel; Pickett, Andrew M.

    2012-01-01

    A large cumulative dose of botulinum toxin type A (BoNT-A), frequent injections, a short interval between treatment cycles, and a long duration of treatment have all been suggested, but not confirmed, to be associated with a high incidence of neutralizing antibodies to the neurotoxin. The aim of this study was to investigate whether these…

  14. Traffic forecasts ignoring induced demand

    DEFF Research Database (Denmark)

    Næss, Petter; Nicolaisen, Morten Skou; Strand, Arvid

    2012-01-01

    Although the phenomenon of induced traffic has been theorized for more than 60 years and is now widely accepted among transport researchers, the traffic-generating effects of road capacity expansion are still often neglected in transport modelling. Such omission can lead to serious bias...... performance of a proposed road project in Copenhagen with and without short-term induced traffic included in the transport model. The available transport model was not able to include long-term induced traffic resulting from changes in land use and in the level of service of public transport. Even though...... the model calculations included only a part of the induced traffic, the difference in cost-benefit results compared to the model excluding all induced traffic was substantial. The results show lower travel time savings, more adverse environmental impacts and a considerably lower benefitcost ratio when...

  15. Water Cycling under Climate Change. Interactions between the water cycle, vegetation and a changing (sub)tropical climate

    NARCIS (Netherlands)

    de Boer, H.J.

    2012-01-01

    The water cycle is an essential component of the climate system because the physical properties of water in its liquid, solid and gaseous phases allow for the redistribution of energy in the oceans and atmosphere. At the scale of individual organisms, water and energy are also essential for the bioc

  16. A traffic model of optical networks based on time-space complexity and traffic grooming

    Institute of Scientific and Technical Information of China (English)

    Zhao Yongli; Zhang Jie; Han Dahai; Wang Lei; Chen Xiuzhong; Gu Wanyi

    2009-01-01

    This paper researched the traffic of optical networks in time-space complexity, proposed a novel traffic model for complex optical networks based on traffic grooming, designed a traffic generator GTS (generator based on time and space) with "centralized + distributed" idea, and then made a simulation in C language. Experiments results show that GTS can produce the virtual network topology which can change dynamically with the characteristic of scaling-free network. GTS can also groom the different traffic and trigger them under real-time or scheduling mechanisms, generating different optical connections. This traffic model is convenient for the simulation of optical networks considering the traffic complexity.

  17. Rapid changes in the light/dark cycle disrupt memory of conditioned fear in mice.

    Directory of Open Access Journals (Sweden)

    Dawn H Loh

    Full Text Available BACKGROUND: Circadian rhythms govern many aspects of physiology and behavior including cognitive processes. Components of neural circuits involved in learning and memory, e.g., the amygdala and the hippocampus, exhibit circadian rhythms in gene expression and signaling pathways. The functional significance of these rhythms is still not understood. In the present study, we sought to determine the impact of transiently disrupting the circadian system by shifting the light/dark (LD cycle. Such "jet lag" treatments alter daily rhythms of gene expression that underlie circadian oscillations as well as disrupt the synchrony between the multiple oscillators found within the body. METHODOLOGY/PRINCIPAL FINDINGS: We subjected adult male C57Bl/6 mice to a contextual fear conditioning protocol either before or after acute phase shifts of the LD cycle. As part of this study, we examined the impact of phase advances and phase delays, and the effects of different magnitudes of phase shifts. Under all conditions tested, we found that recall of fear conditioned behavior was specifically affected by the jet lag. We found that phase shifts potentiated the stress-evoked corticosterone response without altering baseline levels of this hormone. The jet lag treatment did not result in overall sleep deprivation, but altered the temporal distribution of sleep. Finally, we found that prior experience of jet lag helps to compensate for the reduced recall due to acute phase shifts. CONCLUSIONS/SIGNIFICANCE: Acute changes to the LD cycle affect the recall of fear-conditioned behavior. This suggests that a synchronized circadian system may be broadly important for normal cognition and that the consolidation of memories may be particularly sensitive to disruptions of circadian timing.

  18. Timbre-induced pitch shift from the perspective of Signal Detection Theory: the impact of musical expertise, silence interval, and pitch region.

    Science.gov (United States)

    Vurma, Allan

    2014-01-01

    The paradigm of Signal Detection Theory (SDT) was used to analyze the ability of professional pianists (N = 16) and string players (N = 15) to discriminate small F0 differences between consecutive musical tones, presented in pairs, with identical and with different (bright and dull) timbres. The sensitivity (d') and response bias (c) were heavily dependent on the timbral arrangement of the pairs of tones (the "comparable tones"), which can be interpreted as the influence of timbre-induced pitch shift on F0 discrimination. The participants were somewhat biased to "miss" signals when comparable tones had identical timbres and to make "false alarms" when the tones had different timbres. The d' was lowest when the tones with a lower F0 in those stimulus-pairs containing tones with different timbres had a brighter timber, and highest when both tones had bright timbre. On average, the string players had a somewhat higher d' and their perception was slightly less influenced by timbre-induced pitch shift when compared to the pianists. Nevertheless, the dependence of d' and c on the timbral arrangement of the tones was registered in the case of all the participants at all the investigated pitch regions around D#3, D4, and C#5. Furthermore, the presence of a silence of 3.5 s-a silence interval-between the tones to be compared had an impact on both d'- and c-values as well as on the degree of vulnerability to timbre-induced pitch shift.

  19. Solar cycle changes of large-scale solar wind structure

    OpenAIRE

    Manoharan, P. K

    2011-01-01

    In this paper, I present the results on large-scale evolution of density turbulence of solar wind in the inner heliosphere during 1985 - 2009. At a given distance from the Sun, the density turbulence is maximum around the maximum phase of the solar cycle and it reduces to ~70%, near the minimum phase. However, in the current minimum of solar activity, the level of turbulence has gradually decreased, starting from the year 2005, to the present level of ~30%. These results suggest that the sour...

  20. Environmental and climatic changes during Valanginian (Early Cretaceous) perturbations of the carbon cycle

    Science.gov (United States)

    Kujau, A.; Heimhofer, U.; Hochuli, P. A.; Schouten, S.; Thierry, A.; Morales, C.; Mutterlose, J.

    2011-12-01

    coeval shift is negative. PCO2 reconstructions based on the Δδ record point to an increase in atmospheric pCO2 for this time interval. Results are interpreted to reflect an increase in aridity at the French site, whereas conditions become more humid in the hinterland of the Carpathian seaway during the initiation of the carbon cycle perturbation. This would explain for diverging compositions of vegetation and the negative shift in C27 n-alkanes of the Polish site, since an increase in humidity enhances discrimination in land plants and therewith the amount of implemented 12C. The subsequent peak in fern spores may point to supra-regional hostile conditions favoring massive appearance of fern plants, coinciding with pCO2 drawdown, arid conditions, and the initiation of a cooling phase during the plateau-phase of the carbon isotope excursion. Results point to an important role of continental environments during the complex pattern of environmental and climatic changes accompanying and/or causing the Valanginian carbon isotope anomaly.

  1. Revolutionizing Technology Prioritizing Emergency Vehicles in Traffic

    Directory of Open Access Journals (Sweden)

    B. Ramya Sundaram

    2014-08-01

    Full Text Available The following study brings to the fore a technology exclusively engineered to eradicate the snags and inadequacies persisting in the existing system of traffic control and thus aims to provide a sophisticated operation and uninterrupted course for the emergency vehicles. The traffic in Indian roads has shown a tremendous rise over the years and the conventional pre-timed traffic signals and frequent traffic congestions, delaying the road commuters, have led to outrage and chaos on several occasions. This traffic management system has proved a nuisance for the effective operation of emergency vehicles, with the public adding to the woes, as each driver races along with the signal, unmindful of the emergency vehicles. A life threatening scenario ensues when emergency vehicles get blocked by the traffic, due to inefficient traffic management system and subsequently these emergency vehicles get delayed. The existing system requires manual interruption to guide other vehicles when an emergency vehicle passes through traffic junctions. It is therefore essential to implement a self-regulating and automated system in the traffic signals to facilitate smooth movement of emergency vehicles without posing a danger to other vehicles. The innovative traffic control system devised by us provides a truly dependable alternative to monitoring traffic flow when emergency vehicles pass by.

  2. Integrating Research on Global Climate Change and Human Use of the Oceans: a Geospatial Method for Daily Monitoring of Sea Ice and Ship Traffic in the Arctic

    Science.gov (United States)

    Eucker, W.; McGillivary, P. A.

    2012-12-01

    One apparent consequence of global climate change has been a decrease in the extent and thickness of Arctic sea ice more rapidly than models have predicted, while Arctic ship traffic has likewise increased beyond economic predictions. To ensure representative observations of changing climate conditions and human use of the Arctic Ocean, we concluded a method of tracking daily changes in both sea ice and shipping in the Arctic Ocean was needed. Such a process improves the availability of sea ice data for navigational safety and allows future developments to be monitored for understanding of ice and shipping in relation to policy decisions appropriate to optimize sustainable use of a changing Arctic Ocean. The impetus for this work was the 2009 Arctic Marine Shipping Assessment (AMSA) which provided baseline data on Arctic ship traffic. AMSA was based on responses from circumpolar countries, was manpower intensive, and took years to compile. A more timely method of monitoring human use of the Arctic Ocean was needed. To address this, a method of monitoring sea ice on a scale relevant to ship-navigation (internationally required on ships over a certain size, which includes most commercial vessels in the Arctic Ocean. Daily AIS and sea ice observations were chosen for this study. Results of this method of geospatial analysis of the entire arctic are presented for a year long period from April 1, 2010 to March 31, 2011. This confirmed the dominance of European Arctic ship traffic. Arctic shipping is maximal during August and diminishes in September with a minimum in winter, although some shipping continues year-round in perennially ice-free areas. Data are analyzed for the four principal arctic quadrants around the North Pole by season for number and nationality of vessels. The goal of this study was not merely to monitor ship traffic and ice conditions concurrently, but also to demonstrate a new method of ocean monitoring based on daily assimilation, data fusion, and

  3. Global changes in biogeochemical cycles in response to human activities

    Science.gov (United States)

    Moore, Berrien, III; Melillo, Jerry

    1994-01-01

    The main objective of our research was to characterize biogeochemical cycles at continental and global scales in both terrestrial and aquatic ecosystems. This characterization applied to both natural ecosystems and those disturbed by human activity. The primary elements of interest were carbon and nitrogen and the analysis sought to quantify standing stocks and dynamic cycling processes. The translocation of major nutrients from the terrestrial landscape to the atmosphere (via trace gases) and to fluvial systems (via leaching, erosional losses, and point source pollution) were of particular importance to this study. Our aim was to develop the first generation of Earth System Models. Our research was organized around the construction and testing of component biogeochemical models which treated terrestrial ecosystem processes, aquatic nutrient transport through drainage basins, and trace gas exchanges at the continental and global scale. A suite of three complementary models were defined within this construct. The models were organized to operate at a 1/2 degree latitude by longitude level of spatial resolution and to execute at a monthly time step. This discretization afforded us the opportunity to understand the dynamics of the biosphere down to subregional scales, while simultaneously placing these dynamics into a global context.

  4. Adjustment of the annual cycle to climatic change in a long-lived migratory bird specie

    OpenAIRE

    Møller, A.P; E. FLENSTED-JENSEN; W. MARDAL

    2009-01-01

    Climate change has advanced the phenology of many organisms. Migratory animals face particular problems because climate change in the breeding and the wintering range may be asynchronous, preventing rapid response to changing conditions. Advancement in timing of spring migration may have carry-over effects to other parts of the annual cycle, simply because advancement of one event in the annual cycle also advances subsequent events, gradually causing a general shift in the timing of the ent...

  5. Cycle commuting and perceptions of barriers:Stages of change, gender and occupation

    OpenAIRE

    van Bekkum, J.E.; Williams, Joanne; Morris, Paul Graham

    2011-01-01

    Purpose: The aim of this study is to investigate perceptions of cycle commuting barriers in relation to stage of change, gender and occupational role. Stage of change is a key construct of the transtheoretical model of behaviour change that defines behavioural readiness (intentions and actions) into five distinct categories. Design/methodology/approach: A cross-sectional online questionnaire was completed by staff and PhD students (n=831) based in cycle-friendly buildings in a large UK univer...

  6. Estimating soil carbon change and biofuel life-cycle greenhouse gas emissions with economic, ecosystem and life-cycle models

    Science.gov (United States)

    Qin, Z.; Dunn, J.; Kwon, H. Y.; Mueller, S.; Wander, M.

    2015-12-01

    Land-use change (LUC) resulting from biofuel feedstock production can alter soil organic carbon (SOC) stocks of lands producing those crops and the crops they displace, possibly resulting in greenhouse gas (GHG) emissions. LUC GHG emissions included in biofuel life cycle analysis (LCA) have at times been estimated to be so great that biofuels did not offer a greenhouse gas reduction compared to conventional fossil fuels. To improve the accuracy of emissions estimates, SOC changes must be considered at a finer spatial resolution and take into account climate, soil, land use and management factors. This study reports on the incorporation of global LUC as predicted by a computable general equilibrium model (i.e., GTAP) and spatially-explicit modeled SOC estimates (using surrogate CENTURY) for various biofuel feedstock scenarios into a widely-used LCA model (i.e., GREET). Resulting estimates suggest: SOC changes associated with domestic corn production might contribute 2-6% or offset as much as 5% of total corn ethanol life-cycle GHG emissions. On the other hand, domestic LUC GHG emissions for switchgrass ethanol have the potential offset up to 60% of GHG emissions in the fuel's life cycle. Further, large SOC sequestration is predicted for Miscanthus feedstock production, enabling Miscanthus-based ethanol systems to offset all life-cycle GHG emissions and create a net carbon sink. LUC GHG emissions for ethanol derived from corn stover are small compared to other sources. Total life-cycle GHG emissions (g CO2eq MJ-1, 100cm soil) were estimated to be 59-66 for corn ethanol, 14 for stover ethanol, 18-26 for switchgrass ethanol, and -7 - -0.6 for Miscanthus ethanol.

  7. Changes in oscillatory dynamics in the cell cycle of early Xenopus laevis embryos.

    Directory of Open Access Journals (Sweden)

    Tony Y-C Tsai

    2014-02-01

    Full Text Available During the early development of Xenopus laevis embryos, the first mitotic cell cycle is long (∼85 min and the subsequent 11 cycles are short (∼30 min and clock-like. Here we address the question of how the Cdk1 cell cycle oscillator changes between these two modes of operation. We found that the change can be attributed to an alteration in the balance between Wee1/Myt1 and Cdc25. The change in balance converts a circuit that acts like a positive-plus-negative feedback oscillator, with spikes of Cdk1 activation, to one that acts like a negative-feedback-only oscillator, with a shorter period and smoothly varying Cdk1 activity. Shortening the first cycle, by treating embryos with the Wee1A/Myt1 inhibitor PD0166285, resulted in a dramatic reduction in embryo viability, and restoring the length of the first cycle in inhibitor-treated embryos with low doses of cycloheximide partially rescued viability. Computations with an experimentally parameterized mathematical model show that modest changes in the Wee1/Cdc25 ratio can account for the observed qualitative changes in the cell cycle. The high ratio in the first cycle allows the period to be long and tunable, and decreasing the ratio in the subsequent cycles allows the oscillator to run at a maximal speed. Thus, the embryo rewires its feedback regulation to meet two different developmental requirements during early development.

  8. Raf-1 Physically Interacts with Rb and Regulates Its Function: a Link between Mitogenic Signaling and Cell Cycle Regulation

    OpenAIRE

    Wang, Sheng; Ghosh, Richik N.; Chellappan, Srikumar P

    1998-01-01

    Cells initiate proliferation in response to growth factor stimulation, but the biochemical mechanisms linking signals received at the cell surface receptors to the cell cycle regulatory molecules are not yet clear. In this study, we show that the signaling molecule Raf-1 can physically interact with Rb and p130 proteins in vitro and in vivo and that this interaction can be detected in mammalian cells without overexpressing any component. The binding of Raf-1 to Rb occurs subsequent to mitogen...

  9. Cellular automata model for urban road traffic flow considering pedestrian crossing street

    Science.gov (United States)

    Zhao, Han-Tao; Yang, Shuo; Chen, Xiao-Xu

    2016-11-01

    In order to analyze the effect of pedestrians' crossing street on vehicle flows, we investigated traffic characteristics of vehicles and pedestrians. Based on that, rules of lane changing, acceleration, deceleration, randomization and update are modified. Then we established two urban two-lane cellular automata models of traffic flow, one of which is about sections with non-signalized crosswalk and the other is on uncontrolled sections with pedestrians crossing street at random. MATLAB is used for numerical simulation of the different traffic conditions; meanwhile space-time diagram and relational graphs of traffic flow parameters are generated and then comparatively analyzed. Simulation results indicate that when vehicle density is lower than around 25 vehs/(km lane), pedestrians have modest impact on traffic flow, whereas when vehicle density is higher than about 60 vehs/(km lane), traffic speed and volume will decrease significantly especially on sections with non-signal-controlled crosswalk. The results illustrate that the proposed models reconstruct the traffic flow's characteristic with the situation where there are pedestrians crossing and can provide some practical reference for urban traffic management.

  10. Mig-6 regulates endometrial genes involved in cell cycle and progesterone signaling

    International Nuclear Information System (INIS)

    Mitogen inducible gene 6 (Mig-6) is an important mediator of progesterone (P4) signaling to inhibit estrogen (E2) signaling in the uterus. Ablation of Mig-6 in the murine uterus leads to the development of endometrial hyperplasia and E2-induced endometrial cancer. To identify the molecular pathways regulated by Mig-6, we performed microarray analysis on the uterus of ovariectomized Mig-6f/f and PGRcre/+Mig-6f/f (Mig-6d/d) mice treated with vehicle or P4 for 6 h. The results revealed that 772 transcripts were significantly regulated in the Mig-6d/d uterus treated with vehicle as compared with Mig-6f/f mice. The pathway analysis showed that Mig-6 suppressed the expression of gene-related cell cycle regulation in the absence of ovarian steroid hormone. The epithelium of Mig-6d/d mice showed a significant increase in the number of proliferative cells compared to Mig-6f/f mice. This microarray analysis also revealed that 324 genes are regulated by P4 as well as Mig-6. Cited2, the developmentally important transcription factor, was identified as being regulated by the P4-Mig-6 axis. To determine the role of Cited2 in the uterus, we used the mice with Cited2 that were conditionally ablated in progesterone receptor-positive cells (PGRcre/+Cited2f/f; Cited2d/d). Ablation of Cited2 in the uterus resulted in a significant reduction in the ability of the uterus to undergo a hormonally induced decidual reaction. Identification and analysis of these responsive genes will help define the role of P4 as well as Mig-6 in regulating uterine biology. - Highlights: • We identify Mig-6- and P4-regulated uterine genes by microarray analysis. • Mig-6 suppresses cell cycle progression and epithelial cell proliferation in uterus. • We identify the Mig-6 dependent induced genes by P4. • Cited2 plays an important role for decidualization as a P4 and Mig-6 target gene

  11. Mig-6 regulates endometrial genes involved in cell cycle and progesterone signaling

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Jung-Yoon; Kim, Tae Hoon; Lee, Jae Hee [Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Grand Rapids, MI (United States); Dunwoodie, Sally L. [Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010 (Australia); St. Vincent' s Clinical School and the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales 2033 (Australia); Ku, Bon Jeong, E-mail: bonjeong@cnu.ac.kr [Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon (Korea, Republic of); Jeong, Jae-Wook, E-mail: JaeWook.Jeong@hc.msu.edu [Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Grand Rapids, MI (United States); Department of Women' s Health, Spectrum Health System, Grand Rapids, MI (United States)

    2015-07-10

    Mitogen inducible gene 6 (Mig-6) is an important mediator of progesterone (P4) signaling to inhibit estrogen (E2) signaling in the uterus. Ablation of Mig-6 in the murine uterus leads to the development of endometrial hyperplasia and E2-induced endometrial cancer. To identify the molecular pathways regulated by Mig-6, we performed microarray analysis on the uterus of ovariectomized Mig-6{sup f/f} and PGR{sup cre/+}Mig-6{sup f/f} (Mig-6{sup d/d}) mice treated with vehicle or P4 for 6 h. The results revealed that 772 transcripts were significantly regulated in the Mig-6{sup d/d} uterus treated with vehicle as compared with Mig-6{sup f/f} mice. The pathway analysis showed that Mig-6 suppressed the expression of gene-related cell cycle regulation in the absence of ovarian steroid hormone. The epithelium of Mig-6{sup d/d} mice showed a significant increase in the number of proliferative cells compared to Mig-6{sup f/f} mice. This microarray analysis also revealed that 324 genes are regulated by P4 as well as Mig-6. Cited2, the developmentally important transcription factor, was identified as being regulated by the P4-Mig-6 axis. To determine the role of Cited2 in the uterus, we used the mice with Cited2 that were conditionally ablated in progesterone receptor-positive cells (PGR{sup cre/+}Cited2{sup f/f}; Cited2{sup d/d}). Ablation of Cited2 in the uterus resulted in a significant reduction in the ability of the uterus to undergo a hormonally induced decidual reaction. Identification and analysis of these responsive genes will help define the role of P4 as well as Mig-6 in regulating uterine biology. - Highlights: • We identify Mig-6- and P4-regulated uterine genes by microarray analysis. • Mig-6 suppresses cell cycle progression and epithelial cell proliferation in uterus. • We identify the Mig-6 dependent induced genes by P4. • Cited2 plays an important role for decidualization as a P4 and Mig-6 target gene.

  12. Electroencephalographic signals synchronize with behaviors and are sexually dimorphic during the light-dark cycle in reproductive frogs.

    Science.gov (United States)

    Yang, Ping; Fang, Guangzhan; Xue, Fei; Cui, Jianguo; Brauth, Steven E; Tang, Yezhong

    2014-02-01

    Male frogs behave differently from females during the breeding season, particularly with respect to courtship displays and in response to mating signals. In search of physiological correlates of these differences, the present study measured changes in baseline electroencephalogram (EEG) power output within four frequency bands in the telencephalon and mesencephalon, together with changes in locomotor activity as a function of the light-dark cycle in male and female Emei music frogs (Babina daunchina) at the reproductive stage. Previous studies have shown that male vocal activity varies both seasonally and daily in this species and that females use male advertisement calls to locate and select mates. The present results show that both EEG and locomotor activity exhibit highly correlated circadian patterns with peaks around light onset and offset. Importantly, during the reproductive stage, statistically significant sex differences in EEG output across brain regions during the light and dark phases were found indicating that sexual dimorphism exists for EEG activity which may underlie sexually specific information processing and behavioral activities. PMID:24337372

  13. Effects of mental workload on physiological and subjective responses during traffic density monitoring: A field study.

    Science.gov (United States)

    Fallahi, Majid; Motamedzade, Majid; Heidarimoghadam, Rashid; Soltanian, Ali Reza; Miyake, Shinji

    2016-01-01

    This study evaluated operators' mental workload while monitoring traffic density in a city traffic control center. To determine the mental workload, physiological signals (ECG, EMG) were recorded and the NASA-Task Load Index (TLX) was administered for 16 operators. The results showed that the operators experienced a larger mental workload during high traffic density than during low traffic density. The traffic control center stressors caused changes in heart rate variability features and EMG amplitude, although the average workload score was significantly higher in HTD conditions than in LTD conditions. The findings indicated that increasing traffic congestion had a significant effect on HR, RMSSD, SDNN, LF/HF ratio, and EMG amplitude. The results suggested that when operators' workload increases, their mental fatigue and stress level increase and their mental health deteriorate. Therefore, it maybe necessary to implement an ergonomic program to manage mental health. Furthermore, by evaluating mental workload, the traffic control center director can organize the center's traffic congestion operators to sustain the appropriate mental workload and improve traffic control management. PMID:26360199

  14. Concurrency and climate change signal in Scottish flooding

    Science.gov (United States)

    Harding, A. E.; Butler, A.; Goody, N.; Bertram, D.; Baggaley, N.; Tett, S. F.

    2013-12-01

    The Scottish Environment Protection Agency maintains a database of river gauging stations and intensity rain-gauges with a 3-hourly resolution that covers the majority of Scotland. Both SEPA and a number of other Scottish agencies are invested in climate change attribution in this data set. SEPA's main interest lies in trend detection and changes in river level (';stage') data throughout Scotland. Emergency response teams are more concerned with the concurrency of multiple flood events that might stretch their ability to respond effectively. Unfortunately, much of the rainfall signal within SEPA's river-gauge data is altered by land use changes, modified by artificial interventions such as reservoirs, compromised by tidal flow, or obscured by measurement issues. Data reduction techniques, indices of extreme rainfall, and hydrology-driven discrimination have been employed to produce a reduced set of flood-relevant information for 24-hour ';flashy' events. Links between this set and North Atlantic circulation have been explored, as have patterns of mutual occurrence across Scotland and location- and seasonally- dependent trends through time. Both frontal systems and summer convective storms have been characterised in terms of subsequent flood-inducing flow regime, their changing behaviour over the last fifty years, and their spatial extent. This is the first stage of an ongoing project that will intelligently expand to take less robust river and rain-gauge stations into account through statistical analysis and hydrological modelling. It is also the first study of its type to analyse a nation-scale dataset of both rainfall and river flow from multiple catchments for flood event concurrency. As rainfall events are expected to intensify across much of Europe, this kind of research is likely to have an increasing degree of relevance for policy-makers. This project demonstrates that productive, policy-relevant and mutually-rewarding partnerships are already underway.

  15. Accounting for indirect land-use change in the life cycle assessment of biofuel supply chains

    OpenAIRE

    Sanchez, Susan Tarka; Woods, Jeremy; Akhurst, Mark; Brander, Matthew; O'Hare, Michael; Dawson, Terence P.; Edwards, Robert; Liska, Adam J.; Malpas, Rick

    2012-01-01

    The expansion of land used for crop production causes variable direct and indirect greenhouse gas emissions, and other economic, social and environmental effects. We analyse the use of life cycle analysis (LCA) for estimating the carbon intensity of biofuel production from indirect land-use change (ILUC). Two approaches are critiqued: direct, attributional life cycle analysis and consequential life cycle analysis (CLCA). A proposed hybrid ‘combined model’ of the two approaches for ILUC analys...

  16. Selecting noise source and traffic representations that capture urban traffic noise dynamics

    OpenAIRE

    CAN, Arnaud; Leclercq, Ludovic; Lelong, Joël

    2009-01-01

    Considering traffic dynamics greatly improves noise estimation in urban area. This can be achieved by coupling a dynamic traffic model with both noise emission laws and sound propagation calculation. Determining the relevant noise source and traffic representations to estimate classical noise descriptors (LAeq and statistical descriptors) near traffic signals has been recently studied. This research topic is extended in this paper to more specific descriptors which are able to capture noise d...

  17. Anastomotic femoral aneurysms: is an increase in interval between primary operation and aneurysms formation related to change in incidence?

    DEFF Research Database (Denmark)

    Levi, N; Schroeder, T V

    1998-01-01

    Anastomotic pseudoaneurysms continue to be a late complication of vascular surgery, particulary following prosthetic graft procedures. The purpose of this study was to investigate if a previously reported increase in interval between the original operation and the development of pseudoaneurysm...

  18. Investigating traffic light violations by cyclists in Dublin City Centre.

    Science.gov (United States)

    Richardson, Matthew; Caulfield, Brian

    2015-11-01

    This research examines the behaviour of cyclists in Dublin City with specific regard to red light running. A number of specific research questions are raised by this study. These questions address the impact of different infrastructure types on red light running, as well as the behavioural patterns and demographics of offending cyclists. Two data collection methods were used to gather information on cyclists in Dublin City - an observational survey and an online questionnaire. The observational surveys examined cyclist compliance with different traffic signal systems and the impact of on-road and off-road cycle infrastructure. An online questionnaire was used to get direct feedback from cyclists in Dublin City on the reasons (if any) they decide to commit infringement at traffic lights. With the recent growth of cycling in Dublin City (as well as many other international cities) it is vital to accommodate and manage this growing demand by ensuring the safety and road discipline of cyclists. The next few years will be crucial for the continued development of cycling in Dublin, particularly due to the increasing investment by transport planners in cycle infrastructure. It is therefore important to identify now the main factors which influence cyclist's decisions to break red lights in order to guide local traffic authorities in their efforts to reduce such transgressions. PMID:26320736

  19. Effects of changes in frequency on guinea pig ventricular action potential duration and on QT interval under different experimental conditions.

    Science.gov (United States)

    von Savigny, L; Hohnloser, S; Antoni, H

    1981-01-01

    Isolated perfused guinea pig hearts (Langendorff preparation) were arrested by carbachol (0.1-0.2 mg/l) and electrically stimulated in the region of the av-conducting system. The QT interval was determined by means of extracellular electrodes at different driving frequencies. Separate experiments were performed on papillary muscles from the right ventricle to measure the duration of the transmembrane action potential under comparable conditions. At 35 degrees C (Ke+ 5.4 mmol/l) increasing the frequency of stimulation (range 12-120/min) caused the action potential duration (APD) to decrease to a greater extent than the QT interval. Stepwise rising of the external K+ concentration up to 16.2 mmol/l produced a nearly parallel shift to the APD-frequency relation to lower values. Again, the QT interval was less affected by increasing the external K+ concentration than the APD. Stepwise reduction of the temperature down to 20 degrees C prolonged the APD as well as the QT interval, the effects being more pronounced at lower than at higher stimulation frequencies. Under all examined experimental conditions, the APD proved to be markedly shorter than the QT interval even when the latter is diminished by the duration of QRS. The results suggest that no close relation exists between the APD and the QT interval. The observed divergencies may be due to functional differences among various parts of the ventricles.

  20. INTERACTIVE EFFECTS OF SOLAR UV RADIATION AND CLIMATE CHANGE ON BIOGEOCHEMICAL CYCLING

    Science.gov (United States)

    This paper assesses research on the interactions of UV radiation (280-400 nm) and global climate change with global biogeochemical cycles at the Earth's surface. The effects of UV-B (280-315 nm), which are dependent on the stratospheric ozone layer, on biogeochemical cycles are o...

  1. 49 CFR 236.769 - Locking, traffic.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Locking, traffic. 236.769 Section 236.769... Locking, traffic. Electric locking which prevents the manipulation of levers or other devices for changing the direction of traffic on a section of track while that section is occupied or while a...

  2. NEW POSSIBILITIES OF RAILWAY TRAFFIC CONTROL SYSTEMS

    Directory of Open Access Journals (Sweden)

    Lionginas LIUDVINAVIČIUS

    2016-06-01

    Full Text Available This article analyses the train traffic control systems in 1435 mm and 1520 mm gauge railways. The article analyses the aspects of train traffic control and locomotive energy saving by using the coordinates of track profile change that have been received from GPS. In the article, achievements of Lithuanian railways (LG in the area of train traffic control optimisation are presented.

  3. NEW POSSIBILITIES OF RAILWAY TRAFFIC CONTROL SYSTEMS

    OpenAIRE

    Lionginas LIUDVINAVIČIUS; Stasys DAILYDKA; Aleksander SŁADKOWSKI

    2016-01-01

    This article analyses the train traffic control systems in 1435 mm and 1520 mm gauge railways. The article analyses the aspects of train traffic control and locomotive energy saving by using the coordinates of track profile change that have been received from GPS. In the article, achievements of Lithuanian railways (LG) in the area of train traffic control optimisation are presented.

  4. Indole-3-carbinol, a vegetable phytochemical, inhibits adipogenesis by regulating cell cycle and AMPKα signaling.

    Science.gov (United States)

    Choi, Hyeon-Son; Jeon, Hui-Jeon; Lee, Ok-Hwan; Lee, Boo-Yong

    2014-09-01

    Indole-3-carbinol (I3C) is a phytochemical present mainly in cruciferous vegetables. In this study, we investigated the mechanism by which I3C blocks adipogenesis in 3T3-L1 cells, and evaluated the anti-adipogenic effect of I3C in zebrafish. Our data showed that I3C mainly inhibits early differentiation of adipocyte through cell cycle arrest. Inhibition of early differentiation was reflected by down-regulation of early adipogenic factors such as CCAAT-enhancer binding proteins β and δ (C/EBPβ and C/EBPδ), followed by down-regulation of late adipogenic factors such as peroxisome proliferator-activated receptor γ (PPARγ) and C/EBPα, and regulation of signaling molecules. This result was supported by a reduction in triglyceride (TG) levels and TG synthetic enzymes. I3C activated AMP-activated protein kinase α (AMPKα) to inhibit fatty acid synthesis. In addition, an anti-adipogenic effect of I3C was found in zebrafish study. Our data suggest that vegetables-derived I3C could reduce lipid accumulation via various molecular mechanisms in cell.

  5. CATS-based Air Traffic Controller Agents

    Science.gov (United States)

    Callantine, Todd J.

    2002-01-01

    This report describes intelligent agents that function as air traffic controllers. Each agent controls traffic in a single sector in real time; agents controlling traffic in adjoining sectors can coordinate to manage an arrival flow across a given meter fix. The purpose of this research is threefold. First, it seeks to study the design of agents for controlling complex systems. In particular, it investigates agent planning and reactive control functionality in a dynamic environment in which a variety perceptual and decision making skills play a central role. It examines how heuristic rules can be applied to model planning and decision making skills, rather than attempting to apply optimization methods. Thus, the research attempts to develop intelligent agents that provide an approximation of human air traffic controller behavior that, while not based on an explicit cognitive model, does produce task performance consistent with the way human air traffic controllers operate. Second, this research sought to extend previous research on using the Crew Activity Tracking System (CATS) as the basis for intelligent agents. The agents use a high-level model of air traffic controller activities to structure the control task. To execute an activity in the CATS model, according to the current task context, the agents reference a 'skill library' and 'control rules' that in turn execute the pattern recognition, planning, and decision-making required to perform the activity. Applying the skills enables the agents to modify their representation of the current control situation (i.e., the 'flick' or 'picture'). The updated representation supports the next activity in a cycle of action that, taken as a whole, simulates air traffic controller behavior. A third, practical motivation for this research is to use intelligent agents to support evaluation of new air traffic control (ATC) methods to support new Air Traffic Management (ATM) concepts. Current approaches that use large, human

  6. Association Between Media Dose, Ad Tagging, and Changes in Web Traffic for a National Tobacco Education Campaign: A Market-Level Longitudinal Study

    Science.gov (United States)

    Davis, Kevin C; Patel, Deesha; Rodes, Robert; Beistle, Diane

    2016-01-01

    Background In 2012, the US Centers for Disease Control and Prevention (CDC) launched Tips From Former Smokers (Tips), the first federally funded national tobacco education campaign. In 2013, a follow-up Tips campaign aired on national cable television networks, radio, and other channels, with supporting digital advertising to drive traffic to the Tips campaign website. Objective The objective of this study was to use geographic and temporal variability in 2013 Tips campaign television media doses and ad tagging to evaluate changes in traffic to the campaign website in response to specific doses of campaign media. Methods Linear regression models were used to estimate the dose-response relationship between weekly market-level television gross rating points (GRPs) and weekly Web traffic to the Tips campaign website. This relationship was measured using unique visitors, total visits, and page views as outcomes. Ad GRP effects were estimated separately for ads tagged with the Tips campaign website URL and 1-800-QUIT-NOW. Results In the average media market, an increase of 100 television GRPs per week for ads tagged with the Tips campaign website URL was associated with an increase of 650 unique visitors (Padvertising efforts on consumers’ use of campaign-specific websites. PMID:26887959

  7. Multi-Agent Look-Ahead Traffic-Adaptive Control

    NARCIS (Netherlands)

    Van Katwijk, R.T.

    2008-01-01

    The objective of this thesis is to create a distributed, multi-agent, approach to traffic control. This PhD thesis' focus is on the control of a network instrumented by traffic signals.A thorough literature study has been performed, reviewing the current state of the art in traffic signal control.

  8. 采用系统科学方法优化交通信号灯的控制策略%Optimization Control Strategy of Traffic Signal with System Scientific Methods

    Institute of Scientific and Technical Information of China (English)

    张世良

    2012-01-01

    In order to control vehicles easily pass in the intersection,on the basis of the introduction of system structure for traffic signal lamp,run mode and workflow,this paper analyzes different ways in system control which can use different operation patterns at different times to adaptively control vehicle pass time.Traffic induction strategies which can use different open moment according to the space between the two intersections is used to reduce waiting time for vehicle,improve pass efficiency and ensure efficient circulation in the whole traffic system,and other traffic information,such as vehicle speed,type and traffic by vehicle labels can provide basic data of traffic forecast for the road long-term planning and is signality to direct intelligent traffic control.%为了控制车辆在交叉路口顺畅通行,本文在介绍交通信号灯系统结构、运行模式及工作流程的基础上,分析了系统控制中不同策略的方法,使用在不同的时段采用不同的路口控制模式,自适应地控制车辆通行时间,并根据路口间距采用不同的开启时刻以及使用交通诱导策略,减少车辆等待时间,提高车辆通行效率,保证整个交通系统的高效流通,而且通过车载标签及时掌握的车速、车型和交通量等交通信息可以为该路段远期规划的交通预测提供基础数据,对智能交通控制具有很大的指导意义。

  9. Half of the world’s population experience robust changes in the water cycle for a 2 °C warmer world

    International Nuclear Information System (INIS)

    Fresh water is a critical resource on Earth, yet projections of changes in the water cycle resulting from anthropogenic warming are challenging. It is important to not only know the best estimate of change, but also how robust these projections are, where changes occur, which variables will change, and how many people are affected by it. Here we synthesize the changes in the water cycle, based on results of the latest climate model intercomparison (CMIP5). Several variables of the water cycle, such as evaporation and relative humidity, show robust changes over more than 50% of the land area already with an anthropogenic global warming of 1 °C. A warming of 2 °C shows more than half of the world’s population to be directly affected by robust local changes in the water cycle, and everybody experiences a robust change in at least one variable of the water cycle. While the physical changes are widespread, the affected people are concentrated in a few hot-spots mainly in Asia and Central Africa. The occurrence of these hot-spots is driven by population density, as well as by the early emergence of the anthropogenic signal from variability in these areas. Large uncertainties remain in projections of soil moisture and runoff changes. (paper)

  10. Effects of Solar UV Radiation and Climate Change on Biogeochemical Cycling: Interactions and Feedbacks

    Science.gov (United States)

    Solar UV radiation, climate and other drivers of global change are undergoing significant changes and models forecast that these changes will continue for the remainder of this century. Here we assess the effects of solar UV radiation on biogeochemical cycles and the interactions...

  11. Timbre-induced pitch shift from the perspective of Signal Detection Theory: the impact of musical expertise, silence interval and pitch region

    Directory of Open Access Journals (Sweden)

    Allan eVurma

    2014-01-01

    Full Text Available The paradigm of Signal Detection Theory was used to analyze the ability of professional pianists (N = 16 and string players (N = 15 to discriminate small F0 differences between consecutive musical tones, presented in pairs, with identical and with different (bright and dull timbres. The sensitivity (d’ and response bias (c were heavily dependent on the timbral arrangement of the pairs of tones (the comparable tones, which can be interpreted as the influence of timbre-induced pitch shift on F0 discrimination. The participants were somewhat biased to ‘miss’ signals when comparable tones had identical timbres and to make ‘false alarms’ when the tones had different timbres. The d’ was lowest when the tones with a lower F0 in those stimulus-pairs containing tones with different timbres had a brighter timber, and highest when both tones had bright timbre. On average, the string players had a somewhat higher d’ and their perception was slightly less influenced by timbre-induced pitch shift when compared to the pianists. Nevertheless, the dependence of d’ and c on the timbral arrangement of the tones was registered in the case of all the participants at all the investigated pitch regions around D#3, D4 and C#5. Furthermore, the presence of a silence of 3.5 seconds – a silence interval – between the tones to be compared had an impact on both d’ and c values as well as on the degree of vulnerability to timbre-induced pitch shift.

  12. Impact of climate change on carbon cycle in freshwater ecosystems

    Energy Technology Data Exchange (ETDEWEB)

    Kankaala, P.; Ojala, A.; Tulonen, T.; Haapamaeki, J.; Arvola, L. [Helsinki Univ., Lammi (Finland). Lammi Biological Station

    1996-12-31

    The impacts of the expected climate change on Finnish lake ecosystems were studied with the biota of the mesohumic Lake Paeaejaervi, southern Finland. Experimental conditions, from small-scale experiments on single species level to a large-scale ecosystem manipulation, were established to simulate directly the future climate and/or loading of nutrients and dissolved organic matter (DOM) from the drainage area. The experimental studies were accomplished by modelling the carbon flow in the pelagic food web as well as the growth of littoral macrophytes. The main hypothese tested were as follows: As a consequence of the climate change (rising temperature and increasing precipitation) the loading of nutrients and dissolved organic matter (DOM) from the drainage area to the lake will increase. In the pelagic zone this will be first reflected i higher productivity of primary producers and bacteria, but will later affect the entire food chain. Increase in atmospheric CO{sub 2} concentration and ambient temperature as well as longer growing season will enhance the overall productivity of littoral macrophytes. The higher productivity of the littoral zone will be reflected in the pelagic zone an thus may change the whole ecosystem of the lake

  13. LIFE CYCLE DESIGN FRAMEWORK AND DEMONSTRATION PROJECTS - PROFILES OF AT&T AND ALLIED SIGNAL

    Science.gov (United States)

    This document offers guidance and practical experience for integrating environmental considerations into product system development. Life cycle design seeks to minimize the environmental burden associated with a product's life cycle from raw materials acquisition through manufact...

  14. Characterizing post-industrial changes in the ocean carbon cycle in an Earth system model

    OpenAIRE

    Matsumoto, Katsumi; Tokos, Kathy S.; Chikamoto, Megumi O.; Ridgwell, Andy

    2011-01-01

    Understanding the oceanic uptake of carbon from the atmosphere is essential for better constraining the global budget, as well as for predicting the air-borne fraction of CO2 emissions and thus degree of climate change. Gaining this understanding is difficult, because the ‘natural’ carbon cycle, the part of the global carbon cycle unaltered by CO2 emissions, also responds to climate change and ocean acidification. Using a global climate model of intermediate complexity, we assess the evolutio...

  15. Isotope-based reconstruction of the biogeochemical Si cycle : Implications for climate change and human perturbation

    OpenAIRE

    Sun, Xiaole

    2012-01-01

    The global silicon (Si) cycle is of fundamental importance for the global carbon cycle. Diatom growth in the oceans is a major sequestration pathway for carbon on a global scale (often referred to as the biological pump). Patterns of diatoms preserved in marine sediment records can reveal both natural and anthropogenic driven environmental change, which can be used to understand silicon dynamics and climate change. Si isotopes have been shown to have great potential in order to understand the...

  16. PBO H2O: Monitoring the Terrestrial Water Cycle with reflected GPS signals recorded by the Plate Boundary Observatory Network

    Science.gov (United States)

    Small, E. E.; Fairfax, E. J.; Chew, C. C.; Larson, K. M.

    2015-12-01

    Data from NSF's EarthScope Plate Boundary Observatory (PBO), and similar GPS networks worldwide, can be used to monitor the terrestrial water cycle. GPS satellites transmit L-band microwave signals, which are strongly influenced by water at the surface of the Earth. GPS signals take two different paths: (1) the "direct" signal travels from the satellite to the antenna; (2) the "reflected" signal interacts with the Earth's surface before travelling to the antenna. The direct signal is used by geophysicists to measure the position of the antenna. By analyzing these GPS data over multiple years, the motion of the site can be estimated. The effects of reflected signals are generally ignored by geophysicists because they are small. This is not happenstance, as significant effort has been made to design and deploy a GPS antenna that suppresses ground reflections. Our group has developed a remote sensing technique to retrieve terrestrial water cycle variables from GPS data. We extract the water cycle products from signal strength data that measures the interference between the direct and reflected GPS signals. The sensing footprint is intermediate in scale between in situ observations and most remote sensing measurements. Snow depth, snow water equivalent (SWE), near surface soil moisture, and an index of vegetation water content are currently estimated from nearly 500 PBO sites. These PBO H2O products are updated daily and are available online (http://xenon.colorado.edu/portal/index.php). Validation studies show that retrieved products are of sufficient quality to be used in a variety of applications. The root mean square error (RMSE) of GPS-based SWE is 2 cm, based on a comparison to snow survey data at nearly 20 GPS sites. The RMSE of near surface volumetric soil moisture is < 0.04 cm3 cm-3, sufficient for validation of SMAP soil moisture and similar products.

  17. Relevance of hydro-climatic change projection and monitoring for assessment of water cycle changes in the Arctic.

    Science.gov (United States)

    Bring, Arvid; Destouni, Georgia

    2011-06-01

    Rapid changes to the Arctic hydrological cycle challenge both our process understanding and our ability to find appropriate adaptation strategies. We have investigated the relevance and accuracy development of climate change projections for assessment of water cycle changes in major Arctic drainage basins. Results show relatively good agreement of climate model projections with observed temperature changes, but high model inaccuracy relative to available observation data for precipitation changes. Direct observations further show systematically larger (smaller) runoff than precipitation increases (decreases). This result is partly attributable to uncertainties and systematic bias in precipitation observations, but still indicates that some of the observed increase in Arctic river runoff is due to water storage changes, for example melting permafrost and/or groundwater storage changes, within the drainage basins. Such causes of runoff change affect sea level, in addition to ocean salinity, and inland water resources, ecosystems, and infrastructure. Process-based hydrological modeling and observations, which can resolve changes in evapotranspiration, and groundwater and permafrost storage at and below river basin scales, are needed in order to accurately interpret and translate climate-driven precipitation changes to changes in freshwater cycling and runoff. In contrast to this need, our results show that the density of Arctic runoff monitoring has become increasingly biased and less relevant by decreasing most and being lowest in river basins with the largest expected climatic changes.

  18. Fire cycle of the Canada's boreal region and its potential response to global change

    Institute of Scientific and Technical Information of China (English)

    ZHANG Quan-fa; CHEN Wen-jun

    2007-01-01

    Interactions of fire cycle and plant species' reproductive characteristics could determine vegetation distribution pattern of a landscape. In Canada's boreal region, fire cycles before the Little Ice Age (c. 1850s) ranged from 30-130 years and 25-234 years afterwards until the settlement period (c. 1930s) when longer fire cycles occurred in response to climatic change and human interference. Analysis indicated that fire cycles were correlated with growing season (April-October) temperature and precipitation departure from the 1961-1990 normal, varying by regions. Assuming that wildfires will respond to future warming similar to the manner during the past century, an assessment using climatic change scenarios CGCM1, CGCM2 and HadCM2 indicates fire cycles would divert to a range of 80-140 years in the west taiga shield, more than 700 years for the east boreal shield and east taiga shield, and 300-400 years for the boreal plains in 2050.

  19. High intensity interval training in a real world setting: a randomized controlled feasibility study in overweight inactive adults, measuring change in maximal oxygen uptake.

    Directory of Open Access Journals (Sweden)

    Helen Lunt

    Full Text Available BACKGROUND: In research clinic settings, overweight adults undertaking HIIT (high intensity interval training improve their fitness as effectively as those undertaking conventional walking programs but can do so within a shorter time spent exercising. We undertook a randomized controlled feasibility (pilot study aimed at extending HIIT into a real world setting by recruiting overweight/obese, inactive adults into a group based activity program, held in a community park. METHODS: Participants were allocated into one of three groups. The two interventions, aerobic interval training and maximal volitional interval training, were compared with an active control group undertaking walking based exercise. Supervised group sessions (36 per intervention were held outdoors. Cardiorespiratory fitness was measured using VO2max (maximal oxygen uptake, results expressed in ml/min/kg, before and after the 12 week interventions. RESULTS: On ITT (intention to treat analyses, baseline (N = 49 and exit (N = 39 [Formula: see text]O2 was 25.3±4.5 and 25.3±3.9, respectively. Participant allocation and baseline/exit VO2max by group was as follows: Aerobic interval training N =  16, 24.2±4.8/25.6±4.8; maximal volitional interval training N = 16, 25.0±2.8/25.2±3.4; walking N = 17, 26.5±5.3/25.2±3.6. The post intervention change in VO2max was +1.01 in the aerobic interval training, -0.06 in the maximal volitional interval training and -1.03 in the walking subgroups. The aerobic interval training subgroup increased VO2max compared to walking (p = 0.03. The actual (observed, rather than prescribed time spent exercising (minutes per week, ITT analysis was 74 for aerobic interval training, 45 for maximal volitional interval training and 116 for walking (p =  0.001. On descriptive analysis, the walking subgroup had the fewest adverse events. CONCLUSIONS: In contrast to earlier studies, the improvement in cardiorespiratory fitness in a

  20. Assessment of the impact on safety with regard to change in outage interval from 12 to 18 or 24 months at Gentilly-2 Nuclear Generating Station

    Energy Technology Data Exchange (ETDEWEB)

    Vaillancourt, R.; Croteau, M.; Komljenovic, D.; Royer, M. [Hydro-Quebec, Montreal, Quebec (Canada); Bellil, A.; Joober, K. [ENAQ, (Canada); Abdul-Nour, G.; Darragi, M. [Univ. of Quebec in Trois-Rivieres, Trois-Rivieres, Quebec (Canada)

    2003-07-01

    This paper presents the methodology and preliminary results of an impact assessment, concerning safety, resulting from the increase in outage interval from 12 to 18 or 24 months at Gentilly-2 NPP. This change will result in the decrease of the frequency of periodic tests and preventive maintenance performed during planned outages, and modify safety design matrices and reliability studies results and conclusions. (author)

  1. Drought and Carbon Cycling of Grassland Ecosystems under Global Change: A Review

    Directory of Open Access Journals (Sweden)

    Tianjie Lei

    2016-10-01

    Full Text Available In recent years, the increased intensity and duration of droughts have dramatically altered the structure and function of grassland ecosystems, which have been forced to adapt to this change in climate. Combinations of global change drivers such as elevated atmospheric CO2 concentration, warming, nitrogen (N deposition, grazing, and land-use change have influenced the impact that droughts have on grassland C cycling. This influence, to some extent, can modify the relationship between droughts and grassland carbon (C cycling in the multi-factor world. Unfortunately, prior reviews have been primarily anecdotal from the 1930s to the 2010s. We investigated the current state of the study on the interactive impacts of multiple factors under drought scenarios in grassland C cycling and provided scientific advice for dealing with droughts and managing grassland C cycling in a multi-factor world. Currently, adequate information is not available on the interaction between droughts and global change drivers, which would advance our understanding of grassland C cycling responses. It was determined that future experiments and models should specifically test how droughts regulate grassland C cycling under global changes. Previous multi-factor experiments of current and future global change conditions have studied various drought scenarios poorly, including changes in precipitation frequency and amplitude, timing, and interactions with other global change drivers. Multi-factor experiments have contributed to quantifying these potential changes and have provided important information on how water affects ecosystem processes under global change. There is an urgent need to establish a systematic framework that can assess ecosystem dynamic responses to droughts under current and future global change and human activity, with a focus on the combined effects of droughts, global change drivers, and the corresponding hierarchical responses of an ecosystem.

  2. N-glycosylation at Asn residues 554 and 566 of E-cadherin affects cell cycle progression through extracellular signal-regulated protein kinase signaling pathway

    Institute of Scientific and Technical Information of China (English)

    Hongbo Zhao; Xiliang Zha; Lidong Sun; Liying Wang; Zhibin Xu; Feng Zhou; Jianmin Su; Jiawei Jin; Yong Yang; Yali Hu

    2008-01-01

    E-cadherin, which has a widely acknowledged role in mediating calcium-dependent cell-cell adhesion between epithelial cells, also functions as a tumor suppressor. The ectodomain of human E-cadherin contains four potential N-glycosylation sites at Asn residues 554, 566, 618, and 633.We investigated the role of E-cadherin N-glycosylation in cell cycle progression by site-directed mutagenesis. We showed previously that all four potential N-glycosylation sites of E-cadherin were N-glycosylated in human breast carcinoma MDA-MB-435 cells. Removal of N-glycan at Asn633 dramatically affected E-cadherin stability. In this study we showed that E-cadherin mutant missing N-glycans at Asn554, Asn566 and Asn618 failed to induce cell cycle arrest in G1 phase and to suppress cell proliferation in comparison with wild-type E-cadherin. Moreover, N-glycans at Asn554 and Asn566, but not at Asn618, seemed to be indispensable for E-cadherin-mediated suppression of cell cycle progression.Removal of N-glycans at either Asn554 or Asn566 of E-cadherin was accompanied with the activation of the extracellular signal-regulated protein kinase signaling pathway. After treatment with PD98059, an inhibitor of the extraceilular signal-regulated protein kinase signaling pathway, wild-type E-cadherin transfected MDA-MB-435 and E-cadherin N-glycosylation-deficient mutant transfected MDA-MB-435 cells had equivalent numbers of cells in G1 phase. These findings implied that N-glycosylation might be crucial for E-cadherin-mediated suppression of cell cycle progression.

  3. Responses of ecosystem carbon cycling to climate change treatments along an elevation gradient

    Science.gov (United States)

    Wu, Zhuoting; Koch, George W.; Dijkstra, Paul; Bowker, Matthew A.; Hungate, Bruce A.

    2011-01-01

    Global temperature increases and precipitation changes are both expected to alter ecosystem carbon (C) cycling. We tested responses of ecosystem C cycling to simulated climate change using field manipulations of temperature and precipitation across a range of grass-dominated ecosystems along an elevation gradient in northern Arizona. In 2002, we transplanted intact plant–soil mesocosms to simulate warming and used passive interceptors and collectors to manipulate precipitation. We measured daytime ecosystem respiration (ER) and net ecosystem C exchange throughout the growing season in 2008 and 2009. Warming generally stimulated ER and photosynthesis, but had variable effects on daytime net C exchange. Increased precipitation stimulated ecosystem C cycling only in the driest ecosystem at the lowest elevation, whereas decreased precipitation showed no effects on ecosystem C cycling across all ecosystems. No significant interaction between temperature and precipitation treatments was observed. Structural equation modeling revealed that in the wetter-than-average year of 2008, changes in ecosystem C cycling were more strongly affected by warming-induced reduction in soil moisture than by altered precipitation. In contrast, during the drier year of 2009, warming induced increase in soil temperature rather than changes in soil moisture determined ecosystem C cycling. Our findings suggest that warming exerted the strongest influence on ecosystem C cycling in both years, by modulating soil moisture in the wet year and soil temperature in the dry year.

  4. Dryland salinity in Western Australia: managing a changing water cycle.

    Science.gov (United States)

    Taylor, R J; Hoxley, G

    2003-01-01

    Clearing of agricultural land has resulted in significant changes to the surface and groundwater hydrology. Currently about 10% of agricultural land in Western Australia is affected by dryland salinity and between a quarter and a third of the area is predicted to be lost to salinity before a new hydrological equilibrium is reached. This paper develops a general statement describing the changes to the surface and groundwater hydrology of the wheatbelt of Western Australia between preclearing, the year 2000 and into the future. For typical catchments in the wheatbelt it is estimated that average groundwater recharge and surface runoff have increased about tenfold when comparing the current hydrology to that preclearing. Saline groundwater discharge and flood volumes have also increased significantly. Saline groundwater discharge and associated salt load will probably double in the future in line with the predicted increase in the area of dryland salinity. In addition, future increases in the area of dryland salinity/permanent waterlogging will probably double the volumes in flood events and further increase surface runoff in average years. The outcomes of surface and groundwater management trials have been briefly described to estimate how the hydrology would be modified if the trials were implemented at a catchment scale. These results have been used to formulate possible integrated revegetation and drainage management strategies. The future hydrology and impacts with and without integrated management strategies have been compared.

  5. The fully actuated traffic control problem solved by global optimization and complementarity

    Science.gov (United States)

    Ribeiro, Isabel M.; de Lurdes de Oliveira Simões, Maria

    2016-02-01

    Global optimization and complementarity are used to determine the signal timing for fully actuated traffic control, regarding effective green and red times on each cycle. The average values of these parameters can be used to estimate the control delay of vehicles. In this article, a two-phase queuing system for a signalized intersection is outlined, based on the principle of minimization of the total waiting time for the vehicles. The underlying model results in a linear program with linear complementarity constraints, solved by a sequential complementarity algorithm. Departure rates of vehicles during green and yellow periods were treated as deterministic, while arrival rates of vehicles were assumed to follow a Poisson distribution. Several traffic scenarios were created and solved. The numerical results reveal that it is possible to use global optimization and complementarity over a reasonable number of cycles and determine with efficiency effective green and red times for a signalized intersection.

  6. MUSCLE FATIGUE INCREASES METABOLIC COSTS OF ERGOMETER CYCLING WITHOUT CHANGING VO2 SLOW COMPONENT

    Directory of Open Access Journals (Sweden)

    Aivaras Ratkevicius

    2006-09-01

    Full Text Available The aim of the present study was to investigate effects of muscle fatigue on oxygen costs of ergometer cycling and slow component of pulmonary oxygen uptake (VO2 kinetics. Seven young men performed 100 drop jumps (drop height of 40 cm with 20 s of rest after each jump. After the subsequent hour of rest, they cycled at 70, 105, 140 and 175 W, which corresponded to 29.6 ± 5.4, 39.4 ± 7.0, 50.8 ± 8.4 and 65.8 ± 11.8 % of VO2peak, respectively, for 6 min at each intensity with 4-min intervals of rest in between the exercise bouts. The VO2 response to cycling after the exercise (fatigue condition was compared to ergometer cycling without prior exercise (control condition. From 3rd to 6th min of cycling at 105, 140 and 175 W, VO2 was higher (p < 0.05-0.01 when cycling in the fatigue compared to the control condition. Slow component of VO2 kinetics was observed when cycling at 175 W in the control condition (0.17 ± 0.09, l·min-1, mean ± SD, but tended to decrease in the fatigue condition (0.13 ± 0.15 l·min-1. In summary, results of the study are in agreement with the hypothesis that muscle fatigue increases oxygen costs of cycling exercise, but does not affect significantly the slow component of pulmonary oxygen uptake (VO2 kinetics

  7. Wavelet Neural Network Based Traffic Prediction for Next Generation Network

    Institute of Scientific and Technical Information of China (English)

    Zhao Qigang; Li Qunzhan; He Zhengyou

    2005-01-01

    By using netflow traffic collecting technology, some traffic data for analysis are collected from a next generation network (NGN) operator. To build a wavelet basis neural network (NN), the Sigmoid function is replaced with the wavelet in NN. Then the wavelet multiresolution analysis method is used to decompose the traffic signal, and the decomposed component sequences are employed to train the NN. By using the methods, an NGN traffic prediction model is built to predict one day's traffic. The experimental results show that the traffic prediction method of wavelet NN is more accurate than that without using wavelet in the NGN traffic forecasting.

  8. Changes in Driver Behavior Resulting from Pedestrian Countdown Signals

    OpenAIRE

    Huey, S. Brian; Ragland, David

    2007-01-01

    This paper explores the effects that pedestrian countdown signals have on driver behavior. Observations of two intersections, one with pedestrian signals and one without, were made focusing specifically on driver behavior during the amber and red phases. It was found that drivers at the pedestrian countdown intersection were less likely to enter the intersection at the end of the amber phase than those at the traditional pedestrian signal intersection. It was also found that drivers at the in...

  9. Thermal cycling test of few selected inorganic and organic phase change materials

    Energy Technology Data Exchange (ETDEWEB)

    Shukla, Anant; Sawhney, R.L. [Thermal Energy Storage Laboratory, School of Energy and Environmental Studies, Devi Ahilya University, Takshashila Campus, Indore 452001, M.P. (India); Buddhi, D. [Green Hi-Tech Energy Pvt. Ltd., Bari Brahmmana, Adda Sarore, Jammu 180011, Jammu and Kashmir (India)

    2008-12-15

    Thermal cycling tests were performed to check the stability in thermal energy storage systems on some selected organic and inorganic phase change materials (PCMs). The possibility of using these PCMs in thermal energy storage systems were examined on the basis of thermal, chemical and kinetic criteria. Organic and inorganic PCMs were selected to check their thermal stability. Inorganic PCMs were not found suitable after some cycles while thermal cycling for organic PCMs were undertaken up to 1000 thermal cycles and has shown a gradual change in melting temperature and latent heat of fusion. The PCMs were then checked with differential scanning calorimeter (DSC) for their latent heat storage capacity and melting temperature change. (author)

  10. 车路协同下基于交通密度的交叉口交通信号控制方法与仿真%Traffic Signal Control Method and Simulation Based on Traffic Density in Cooperative Vehicle Infrastructure System

    Institute of Scientific and Technical Information of China (English)

    林晓辉

    2014-01-01

    车路协同环境下路侧单元可实时获取车辆的位置、速度等信息,为改进交通信号控制提供了机遇和条件。本文借助感应控制方法的思路,以单个交叉口为研究对象,提出车路协同下基于交通密度的交通信号控制方法,该算法将依据交叉口进口道的交通密度,实时选择车流放行方向,并依据排队消散时间确定进口放行绿灯时间。为验证算法的有效性,以虎门大道---连升路交叉口为例,利用Vissim交通仿真软件,对高峰、平峰、低峰等3个交通需求分别进行仿真建模,并分别分析同一交通需求下,本文算法与感应控制方式、定时控制方式的平均行程时间、平均延误时间、平均停车次数及平均排队长度等各项交通信号控制指标优劣。仿真结果表明:在不同交通需求下,与感应控制方式、定时控制方式相比,本文算法各项交通信号控制指标均有明显的改善。%In a cooperative vehicle infrastructure system ( CVIS) , the road site unit can get the information about the position and speed of vehicles , which provides opportunities and conditions for improving traffic signal control .A single intersection is taken as the research object in this paper .A traffic signal control method is proposed based on traffic density in the CVIS by means of induction control method .This algo-rithm can choose the direction of flow based on the biggest traffic density of the import lanes , and deter-mine entrance green time by the queue dissipation time .In order to verify the effectiveness of the algo-rithm, Humen-Liansheng intersection is taken as an example .Simulation models for the peak , flat peak, and low peak are built respectively by using the Vissim traffic simulation software .Analysis is also conduc-ted to evaluate the traffic signal control indexes for the proposed algorithm , the induction control method , and the fix control mode under the same

  11. Increased atmospheric SO₂ detected from changes in leaf physiognomy across the Triassic-Jurassic boundary interval of East Greenland.

    Directory of Open Access Journals (Sweden)

    Karen L Bacon

    Full Text Available The Triassic-Jurassic boundary (Tr-J; ∼201 Ma is marked by a doubling in the concentration of atmospheric CO2, rising temperatures, and ecosystem instability. This appears to have been driven by a major perturbation in the global carbon cycle due to massive volcanism in the Central Atlantic Magmatic Province. It is hypothesized that this volcanism also likely delivered sulphur dioxide (SO2 to the atmosphere. The role that SO2 may have played in leading to ecosystem instability at the time has not received much attention. To date, little direct evidence has been presented from the fossil record capable of implicating SO2 as a cause of plant extinctions at this time. In order to address this, we performed a physiognomic leaf analysis on well-preserved fossil leaves, including Ginkgoales, bennettites, and conifers from nine plant beds that span the Tr-J boundary at Astartekløft, East Greenland. The physiognomic responses of fossil taxa were compared to the leaf size and shape variations observed in nearest living equivalent taxa exposed to simulated palaeoatmospheric treatments in controlled environment chambers. The modern taxa showed a statistically significant increase in leaf roundness when fumigated with SO2. A similar increase in leaf roundness was also observed in the Tr-J fossil taxa immediately prior to a sudden decrease in their relative abundances at Astartekløft. This research reveals that increases in atmospheric SO2 can likely be traced in the fossil record by analyzing physiognomic changes in fossil leaves. A pattern of relative abundance decline following increased leaf roundness for all six fossil taxa investigated supports the hypothesis that SO2 had a significant role in Tr-J plant extinctions. This finding highlights that the role of SO2 in plant biodiversity declines across other major geological boundaries coinciding with global scale volcanism should be further explored using leaf physiognomy.

  12. Increased atmospheric SO₂ detected from changes in leaf physiognomy across the Triassic-Jurassic boundary interval of East Greenland.

    Science.gov (United States)

    Bacon, Karen L; Belcher, Claire M; Haworth, Matthew; McElwain, Jennifer C

    2013-01-01

    The Triassic-Jurassic boundary (Tr-J; ∼201 Ma) is marked by a doubling in the concentration of atmospheric CO2, rising temperatures, and ecosystem instability. This appears to have been driven by a major perturbation in the global carbon cycle due to massive volcanism in the Central Atlantic Magmatic Province. It is hypothesized that this volcanism also likely delivered sulphur dioxide (SO2) to the atmosphere. The role that SO2 may have played in leading to ecosystem instability at the time has not received much attention. To date, little direct evidence has been presented from the fossil record capable of implicating SO2 as a cause of plant extinctions at this time. In order to address this, we performed a physiognomic leaf analysis on well-preserved fossil leaves, including Ginkgoales, bennettites, and conifers from nine plant beds that span the Tr-J boundary at Astartekløft, East Greenland. The physiognomic responses of fossil taxa were compared to the leaf size and shape variations observed in nearest living equivalent taxa exposed to simulated palaeoatmospheric treatments in controlled environment chambers. The modern taxa showed a statistically significant increase in leaf roundness when fumigated with SO2. A similar increase in leaf roundness was also observed in the Tr-J fossil taxa immediately prior to a sudden decrease in their relative abundances at Astartekløft. This research reveals that increases in atmospheric SO2 can likely be traced in the fossil record by analyzing physiognomic changes in fossil leaves. A pattern of relative abundance decline following increased leaf roundness for all six fossil taxa investigated supports the hypothesis that SO2 had a significant role in Tr-J plant extinctions. This finding highlights that the role of SO2 in plant biodiversity declines across other major geological boundaries coinciding with global scale volcanism should be further explored using leaf physiognomy.

  13. Microbial mediation of biogeochemical cycles revealed by simulation of global changes with soil transplant and cropping.

    Science.gov (United States)

    Zhao, Mengxin; Xue, Kai; Wang, Feng; Liu, Shanshan; Bai, Shijie; Sun, Bo; Zhou, Jizhong; Yang, Yunfeng

    2014-10-01

    Despite microbes' key roles in driving biogeochemical cycles, the mechanism of microbe-mediated feedbacks to global changes remains elusive. Recently, soil transplant has been successfully established as a proxy to simulate climate changes, as the current trend of global warming coherently causes range shifts toward higher latitudes. Four years after southward soil transplant over large transects in China, we found that microbial functional diversity was increased, in addition to concurrent changes in microbial biomass, soil nutrient content and functional processes involved in the nitrogen cycle. However, soil transplant effects could be overridden by maize cropping, which was attributed to a negative interaction. Strikingly, abundances of nitrogen and carbon cycle genes were increased by these field experiments simulating global change, coinciding with higher soil nitrification potential and carbon dioxide (CO2) efflux. Further investigation revealed strong correlations between carbon cycle genes and CO2 efflux in bare soil but not cropped soil, and between nitrogen cycle genes and nitrification. These findings suggest that changes of soil carbon and nitrogen cycles by soil transplant and cropping were predictable by measuring microbial functional potentials, contributing to a better mechanistic understanding of these soil functional processes and suggesting a potential to incorporate microbial communities in greenhouse gas emission modeling.

  14. Climate change in asset management of infrastructure: A risk-based methodology applied to disruption of traffic on road networks due to the flooding of tunnels

    OpenAIRE

    Huibregtse, E.; Morales Napoles, O.; Hellebrandt, L.; D. Paprotny; S. De Wit

    2016-01-01

    This paper presents a risk-based method to quantify climate change effects on road infrastructure, as a support for decision-making on interventions. This can be implemented in climate adaptation plans as an element of asset management. The method is illustrated by a specific case in which traffic on a road network is disrupted by the flooding of a tunnel due to extreme rainfall. Novel techniques to describe both probability of occurrence and consequences of an event are integrated into the p...

  15. Changes in cisternal udder compartment induced by milking interval in dairy goats milked once or twice daily

    DEFF Research Database (Denmark)

    Salama, A A K; Caja, G; Such, X;

    2004-01-01

    Fourteen Murciano-Granadina dairy goats were used to evaluate udder compartments (cisternal and alveolar) and cisternal recoil after an oxytocin (OT) challenge at different milking intervals (8, 16, and 24 h) during wk 7 of lactation. Goats were milked once (1x; n = 7) or twice (2x; n = 7) daily ...

  16. Flexibility in animal signals facilitates adaptation to rapidly changing environments.

    Directory of Open Access Journals (Sweden)

    Darren S Proppe

    Full Text Available Charles Darwin posited that secondary sexual characteristics result from competition to attract mates. In male songbirds, specialized vocalizations represent secondary sexual characteristics of particular importance because females prefer songs at specific frequencies, amplitudes, and duration. For birds living in human-dominated landscapes, historic selection for song characteristics that convey fitness may compete with novel selective pressures from anthropogenic noise. Here we show that black-capped chickadees (Poecile atricapillus use shorter, higher-frequency songs when traffic noise is high, and longer, lower-frequency songs when noise abates. We suggest that chickadees balance opposing selective pressures by use low-frequency songs to preserve vocal characteristics of dominance that repel competitors and attract females, and high frequency songs to increase song transmission when their environment is noisy. The remarkable vocal flexibility exhibited by chickadees may be one reason that they thrive in urban environments, and such flexibility may also support subsequent genetic adaptation to an increasingly urbanized world.

  17. Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning

    Science.gov (United States)

    Hadjivasiliou, Zena; Bonin, Hope; He, Li; Perrimon, Norbert; Charras, Guillaume; Baum, Buzz

    2016-01-01

    Coordinating cell differentiation with cell growth and division is crucial for the successful development, homeostasis and regeneration of multicellular tissues. Here, we use bristle patterning in the fly notum as a model system to explore the regulatory and functional coupling of cell cycle progression and cell fate decision-making. The pattern of bristles and intervening epithelial cells (ECs) becomes established through Notch-mediated lateral inhibition during G2 phase of the cell cycle, as neighbouring cells physically interact with each other via lateral contacts and/or basal protrusions. Since Notch signalling controls cell division timing downstream of Cdc25, ECs in lateral contact with a Delta-expressing cell experience higher levels of Notch signalling and divide first, followed by more distant neighbours, and lastly Delta-expressing cells. Conversely, mitotic entry and cell division makes ECs refractory to lateral inhibition signalling, fixing their fate. Using a combination of experiments and computational modelling, we show that this reciprocal relationship between Notch signalling and cell cycle progression acts like a developmental clock, providing a delimited window of time during which cells decide their fate, ensuring efficient and orderly bristle patterning. PMID:27226324

  18. Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning.

    Science.gov (United States)

    Hunter, Ginger L; Hadjivasiliou, Zena; Bonin, Hope; He, Li; Perrimon, Norbert; Charras, Guillaume; Baum, Buzz

    2016-07-01

    Coordinating cell differentiation with cell growth and division is crucial for the successful development, homeostasis and regeneration of multicellular tissues. Here, we use bristle patterning in the fly notum as a model system to explore the regulatory and functional coupling of cell cycle progression and cell fate decision-making. The pattern of bristles and intervening epithelial cells (ECs) becomes established through Notch-mediated lateral inhibition during G2 phase of the cell cycle, as neighbouring cells physically interact with each other via lateral contacts and/or basal protrusions. Since Notch signalling controls cell division timing downstream of Cdc25, ECs in lateral contact with a Delta-expressing cell experience higher levels of Notch signalling and divide first, followed by more distant neighbours, and lastly Delta-expressing cells. Conversely, mitotic entry and cell division makes ECs refractory to lateral inhibition signalling, fixing their fate. Using a combination of experiments and computational modelling, we show that this reciprocal relationship between Notch signalling and cell cycle progression acts like a developmental clock, providing a delimited window of time during which cells decide their fate, ensuring efficient and orderly bristle patterning. PMID:27226324

  19. Interbirth intervals

    OpenAIRE

    Haig, David

    2014-01-01

    Background and objectives: Interbirth intervals (IBIs) mediate a trade-off between child number and child survival. Life history theory predicts that the evolutionarily optimal IBI differs for different individuals whose fitness is affected by how closely a mother spaces her children. The objective of the article is to clarify these conflicts and explore their implications for public health. Methodology: Simple models of inclusive fitness and kin conflict address the evolution of human birth-...

  20. Effects of global climate change and organic pollution on nutrient cycling in marine sediments

    OpenAIRE

    Sanz-Lázaro, C.; T. Valdemarsen; Holmer, M.

    2015-01-01

    Increasing ocean temperature due to climate change is an important anthropogenic driver of ecological change in coastal systems, where sediments play a major role in nutrient cycling. Our ability to predict ecological consequences of climate change is enhanced by simulating real scenarios especially when the interactions among drivers may not be just additive. Based on predicted climate change scenarios, we tested the effect of temperature and organic pollution on nutrient r...

  1. The Interactive Effects of Estrogen and Progesterone on Changes in Emotional Eating Across the Menstrual Cycle

    OpenAIRE

    Klump, Kelly L.; Keel, Pamela K.; Racine, Sarah E.; Burt, S. Alexandra; Neale, Michael,; Sisk, Cheryl L.; Boker, Steven; Hu, Jean Yueqin

    2012-01-01

    Studies suggest that within-person changes in estrogen and progesterone predict changes in binge eating across the menstrual cycle. However, samples have been extremely small (maximum N = 9), and analyses have not examined the interactive effects of hormones that are critical for changes in food intake in animals. The aims of the current study were to examine ovarian hormone interactions in the prediction of within-subject changes in emotional eating in the largest sample of women to date (N ...

  2. Adaptation of the QT interval to heart rate changes in isolated perfused guinea pig heart: influence of amiodarone and D-sotalol.

    Science.gov (United States)

    Padrini, R; Speranza, G; Nollo, G; Bova, S; Piovan, D; Antolini, R; Ferrari, M

    1997-05-01

    The inadequacy of the QT interval to shorten following heart rate increase is a feature of the inherited long QT syndrome and may have a role in the genesis of the typical arrhythmias associated with this syndrome (torsade des pointes). The aim of our study was to evaluate whether drugs that prolong the QT interval, such as amiodarone and D-sotalol, may also impair the ability of the QT interval to adapt to sudden heart rate changes. Experiments were carried out on isolated perfused guinea pig hearts (Langendorff preparation). Driving frequency was changed, in steps, every two minutes (Hz: 2.5-3-2.5-3.75-2.5-5-2.5), while epicardial ECG was continuously recorded on magnetic tape. QT interval was automatically measured by means of a beat-by-beat analysis program. D-sotalol was added to the perfusion medium at a concentration of 4 micrograms ml-1, while amiodarone was administered, before in vitro evaluation, for seven days (50 mg kg-1 per day, intraperitoneally). In control experiments two phases of QT adaptation were identified: an abrupt QT shortening at the first beat after frequency change (QT1), followed by a gradual, exponential QT shortening that reached a new steady state in about 1 min (half life: 13 sec). The electrical restitution curve (the relation between QT1 and the corresponding diastolic interval) had a rate constant of 57 +/- 8 ms. Neither drug changed the slow component of QT adaptation. However, both drugs increased the ability of QT to shorten upon premature stimulation: D-sotalol by increasing the rate constant of the restitution curve and amiodarone by decreasing the y-intercept. Our results indicate that D-sotalol and amiodarone do not impair QT shortening during tachycardia but, on the contrary, they may favour QT adaptation, thus reducing the likelihood of the potentially lethal 'R on T phenomenon'. This may be an additional mechanism by which these drugs can exert their antifibrillatory action.

  3. A Comparison of Tram Priority at Signalized Intersections

    CERN Document Server

    Zhang, Lele

    2013-01-01

    We study tram priority at signalized intersections using a stochastic cellular automaton model for multimodal traffic flow. We simulate realistic traffic signal systems, which include signal linking and adaptive cycle lengths and split plans, with different levels of tram priority. We find that tram priority can improve service performance in terms of both average travel time and travel time variability. We consider two main types of tram priority, which we refer to as full and partial priority. Full tram priority is able to guarantee service quality even when traffic is saturated, however, it results in significant costs to other road users. Partial tram priority significantly reduces tram delays while having limited impact on other traffic, and therefore achieves a better result in terms of the overall network performance. We also study variations in which the tram priority is only enforced when trams are running behind schedule, and we find that those variations retain almost all of the benefit for tram op...

  4. Cycles of strategies and changes of distribution in public goods game: An experimental investigation

    CERN Document Server

    Xu, Bin

    2013-01-01

    In this communication, a simple mechanism in the optional public goods game is experimentally investigated using two experimental settings; and first time, the cyclic strategy pattern in full state space is demonstrated by means of velocity. It is, furthermore, elaborated that the strategies of cooperation, defection and nonparticipant form a Rock-Paper-Scissors type cycle, and the cycle of three strategies are persistent over 200 rounds. This cycle is very similar to the cycle given by evolutionary dynamics e.g. replicator dynamics. The mechanism that nonparticipant can sustain cooperation is driven by the Rock-Paper-Scissors type of cyclic dominance in the three strategies. That is, if the cycle is existent, the cooperation will always sustain. Meanwhile, the distribution of social states changes in the state space and from cooperation as the most frequent strategy to defection and, from defection to nonparticipant, forms a clear rotation path in a long run. These results seem to implicate that the evolutio...

  5. Adaptation to Climate Change: The Case of A Combined Cycle Power Plant

    OpenAIRE

    Asian Development Bank (ADB)

    2012-01-01

    This report aims to demonstrate how a rapid climate change impact assessment can be used to identify the possible impacts of climate change on a thermal power investment project. For this demonstration, the O MON IV Combined Cycle Power Station Project in Southern Viet Nam is used for illustrative purposes.

  6. Cooperation as a signal of genetic or phenotypic quality in female mate choice? Evidence from preferences across the menstrual cycle.

    Science.gov (United States)

    Farrelly, Daniel

    2011-08-01

    Previous research highlighting the role sexual selection may play in the evolution of human cooperation has yet to distinguish what qualities such behaviours actually signal. The aim here was to examine whether female preferences for male cooperative behaviours are because they signal genetic or indirect phenotypic quality. This was possible by taking into account female participants' stage of menstrual cycle, as much research has shown that females at the most fertile stage show greater preferences specifically for signals of genetic quality than any other stage, particularly for short-term relationships. Therefore, different examples of cooperation (personality, costly signals, heroism) and the mate preferences for altruistic traits self-report scale were used across a series of four experiments to examine females' attitudes towards cooperation in potential mates for different relationship lengths at different stages of the menstrual cycle. The results here consistently show that female fertility had no effect on perceptions of cooperative behaviour, and that such traits were considered more important for long-term relationships. Therefore, this provides strong evidence that cooperative behaviour is important in mate choice as predominantly a signal of phenotypic rather than genetic quality.

  7. A Drosophila model for age-associated changes in sleep:wake cycles.

    Science.gov (United States)

    Koh, Kyunghee; Evans, Joshua M; Hendricks, Joan C; Sehgal, Amita

    2006-09-12

    One of the most consistent behavioral changes that occurs with age in humans is the loss of sleep consolidation. This can be quite disruptive and yet little is known about its underlying basis. To better understand the effects of aging on sleep:wake cycles, we sought to study this problem in Drosophila melanogaster, a powerful system for research on aging and behavior. By assaying flies of different ages as well as monitoring individual flies constantly over the course of their lifetime, we found that the strength of sleep:wake cycles decreased and that sleep became more fragmented with age in Drosophila. These changes in sleep:wake cycles became faster or slower with manipulations of ambient temperature that decreased or increased lifespan, respectively, demonstrating that they are a function of physiological rather than chronological age. The effect of temperature on lifespan was not mediated by changes in overall activity level or sleep amount. Flies treated with the oxidative stress-producing reagent paraquat showed a breakdown of sleep:wake cycles similar to that seen with aging, leading us to propose that the accumulation of oxidative damage with age contributes to the changes in rhythm and sleep. Together, these findings establish Drosophila as a valuable model for studying age-associated sleep fragmentation and breakdown of rhythm strength, and indicate that these changes in sleep:wake cycles are an integral part of the physiological aging process. PMID:16938867

  8. Evaluation of the global water cycle's response to current and future drivers of climate change

    OpenAIRE

    Warnaars, Tanya

    2010-01-01

    Understanding the water cycle and how it will be modified by climate change is a real challenge. With increasing temperatures the hydrological cycle is expected to intensify and extreme event will become more widespread. Some expected outcomes are more intense rainfall events, which can lead to increased floods and increased erosion; as well as a more intermittent pattern of rainfall leading to droughts. These effects are anticipated to occur on a global scale and an integrated approach is ne...

  9. Changes in climate and secular population cycles in China, 1000 CE to 1911

    OpenAIRE

    Lee, HF; Zhang, DD

    2010-01-01

    Many studies of secular population cycles in historical China conclude that when population is large - relative to the land's carrying capacity - further population increase can lead to mortality crises through war, famine and epidemics, resulting in subsequent population decline. In these studies, population cycles are thought to be driven primarily by population growth. Nevertheless, some scholars have noted a strong correlation between deteriorating climate, dynastic change, and population...

  10. Revenue cycle optimization in health care institutions. A conceptual framework for change management.

    Science.gov (United States)

    Mugdh, Mrinal; Pilla, Satya

    2012-01-01

    Health care providers in the United States are constantly faced with the enormous challenge of optimizing their revenue cycle to improve their overall financial performance. These challenges keep evolving in both scope and complexity owing to a host of internal and external factors. Furthermore, given the lack of control that health care providers have over external factors, any attempt to successfully optimize the revenue cycle hinges on several critical improvements aimed at realigning the internal factors. This study provides an integrated change management model that aims to reengineer and realign the people-process-technology framework by using the principles of lean and Six Sigma for revenue cycle optimization.

  11. Cocaine-induced changes in NMDA receptor signaling

    OpenAIRE

    Ortinski, Pavel I.

    2014-01-01

    Addictive states are often thought to rely on lasting modification of signaling at relevant synapses. A long-standing theory posits that activity at N-methyl-D-aspartate receptors (NMDARs) is a critical component of long-term synaptic plasticity in many brain areas. Indeed, NMDAR signaling has been found to play a role in the etiology of addictive states, in particular following cocaine exposure. However, no consensus is apparent with respect to the specific effects of cocaine exposure on NMD...

  12. A Methodology for Integrated, Multiregional Life Cycle Assessment Scenarios under Large-Scale Technological Change.

    Science.gov (United States)

    Gibon, Thomas; Wood, Richard; Arvesen, Anders; Bergesen, Joseph D; Suh, Sangwon; Hertwich, Edgar G

    2015-09-15

    Climate change mitigation demands large-scale technological change on a global level and, if successfully implemented, will significantly affect how products and services are produced and consumed. In order to anticipate the life cycle environmental impacts of products under climate mitigation scenarios, we present the modeling framework of an integrated hybrid life cycle assessment model covering nine world regions. Life cycle assessment databases and multiregional input-output tables are adapted using forecasted changes in technology and resources up to 2050 under a 2 °C scenario. We call the result of this modeling "technology hybridized environmental-economic model with integrated scenarios" (THEMIS). As a case study, we apply THEMIS in an integrated environmental assessment of concentrating solar power. Life-cycle greenhouse gas emissions for this plant range from 33 to 95 g CO2 eq./kWh across different world regions in 2010, falling to 30-87 g CO2 eq./kWh in 2050. Using regional life cycle data yields insightful results. More generally, these results also highlight the need for systematic life cycle frameworks that capture the actual consequences and feedback effects of large-scale policies in the long term. PMID:26308384

  13. A nonstoichiometric structural model to characterize changes in the nickel hydroxide electrode during cycling

    International Nuclear Information System (INIS)

    Experimental capacities and mass changes are recorded using an electrochemical quartz crystal microbalance during the first 9 charge and discharge cycles of nickel hydroxide thin films cycled in 3.0 weight percent (wt%) potassium hydroxide electrolyte. For the first time, the film capacities have been corrected for the oxygen evolution side reaction, and the data used as input into the point defect-containing structural model to track the changes that occur during short-term cycling. Variations in capacity and mass during formation and charge/discharge cycling are related to changes in the point defect parameters, thus providing a structural origin for the unique experimental variations observed here and often reported in the literature, but previously unexplained. Proton-, potassium-, and water-content vary in the active material during charge/discharge cycling. The observed capacity loss, or ''capacity fade'', is explained by incomplete incorporation of potassium ions in (or near) the nickel vacancy during charge, as additional protons are then allowed to occupy the vacant lattice site. The increase in water content during reduction parallels the expansion of the electrode that is well known during cycling. This result confirms the origin of the swelling phenomenon as being caused by water incorporation. The model and methodology developed in this paper can be used to correlate electrochemical signatures with material chemical structure

  14. A multiagent urban traffic simulation

    CERN Document Server

    Tranouez, Pierrick; Langlois, Patrice

    2012-01-01

    We built a multiagent simulation of urban traffic to model both ordinary traffic and emergency or crisis mode traffic. This simulation first builds a modeled road network based on detailed geographical information. On this network, the simulation creates two populations of agents: the Transporters and the Mobiles. Transporters embody the roads themselves; they are utilitarian and meant to handle the low level realism of the simulation. Mobile agents embody the vehicles that circulate on the network. They have one or several destinations they try to reach using initially their beliefs of the structure of the network (length of the edges, speed limits, number of lanes etc.). Nonetheless, when confronted to a dynamic, emergent prone environment (other vehicles, unexpectedly closed ways or lanes, traffic jams etc.), the rather reactive agent will activate more cognitive modules to adapt its beliefs, desires and intentions. It may change its destination(s), change the tactics used to reach the destination (favorin...

  15. Subjective effects of traffic noise exposure, II: Comparisons of noise indices, response scales, and the effects of changes in noise levels

    Science.gov (United States)

    Langdon, F. J.; Griffiths, I. D.

    1982-07-01

    Traffic noise and social surveys were carried out at eight London suburban sites. Dwellings at the selected sites were exposed to noise from freely flowing traffic at levels which ranged from 57 to 82 dB(A), measured as 18 hour L10. The study was designed to obtain noise measurements and subjective responses from residents on four repeated occasions throughout the year. A total of 1363 interviews was conducted, 222 respondents each completing four interviews. Traffic noise was measured as L10, L50 and Leq in both linear and A-weighted form. The eight noise indices were found to be very highly intercorrelated. The correlations between each of these and the subjective responses were all equally high. It was therefore not possible to select a "best" index of noise in terms of nuisance experienced by residents, even when the most highly reliable data, derived from averaging responses for the four repeated interviews, were employed. Subjective responses were measured by means of a 7-point scale of "dissatisfaction" and a 4-point verbal scale of "bother" and the former was found to be a significantly better correlate of noise exposure. The data from these eight sites, which underwent no change in noise levels during the survey, were compared with data obtained in "before and after" studies conducted over a roughly similar period. "Dissatisfaction" and "bother" scores for the "after" condition were found to differ from those which would have been predicted from stable and unchanging conditions. A number of possible reasons for this finding are discussed and it is suggested that prediction of the effects resulting from noise reduction procedures requires further study.

  16. Assessing Effects of Climate Change on Biogeochemical Cycling of Trace Metals in Alluvial and Coastal Watersheds

    OpenAIRE

    Lee, Ming-Kuo; Natter, Michael; Keevan, Jeff; Guerra, Kirsten; Saunders, James; Uddin, Ashraf; Humayun, Munir; Wang, Yang; Keimowitz, Alison R.

    2013-01-01

    Assessing the impacts of climate changes on water quality requires an understanding of the biogeochemical cycling of trace metals. Evidence from research on alluvial aquifers and coastal watersheds shows direct impacts of climate change on the fate and transformation of trace metals in natural environments. The case studies presented here use field data and numerical modeling techniques to test assumptions about the effects of climate change on natural arsenic contamination of groundwater in ...

  17. Enhancing energy expenditure and enjoyment of exercise during pregnancy through the addition of brief higher intensity intervals to traditional continuous moderate intensity cycling

    OpenAIRE

    Ong, Ming Jing; Wallman, Karen E.; Fournier, Paul A.; Newnham, John P; Guelfi, Kym J

    2016-01-01

    Background Current guidelines recommend that pregnant women without contraindications should engage in 30 min or more of moderate intensity exercise on most days of the week, however, many women fail to achieve this goal. This study examined the effect of adding brief higher intensity intervals to traditional continuous moderate intensity exercise on energy expenditure and the enjoyment of exercise in late pregnancy. This is important to determine given that any additional energy expenditure ...

  18. Impacts of climate change on nutrient cycling in semi-arid and arid ecosystems

    Energy Technology Data Exchange (ETDEWEB)

    Belnap, J. [National Biological Survey, Moab, UT (United States)

    1995-09-01

    Effective precipitation is a major factor in determining nutrient pathways in different ecosystems. Soil flora and fauna play a critical role in nutrient cycles of all ecosystems. Temperature, timing, and amounts of precipitation affect population composition, activity levels, biomass, and recovery rates from disturbance. Changes in these variables can result in very different inputs and outputs for different nutrients. As a result, areas with less effective precipitation have very different nutrient cycles than more mesic zones. Climate change, therefore, can profoundly affect the nutrient cycles of ecosystems. Nitrogen cycles may be especially sensitive to changes in temperature and to timing and amounts of precipitation. Rainfall contains varying amounts of nitrogen compounds. Changes in amounts of rainfall will change amounts of nitrogen available to these systems. Because rainfall is limited in semi-arid and regions, these systems tend to be more dependent on microbial populations for nitrogen input. Consequently, understanding the effects of climate change on these organisms is critical in understanding the overall effect on ecosystems.

  19. Walking (and cycling to change the city Camminare (e pedalare per trasformare la città

    Directory of Open Access Journals (Sweden)

    Arnaldo Cecchini

    2012-01-01

    Full Text Available

    Contemporary city is mainly designed and managed in order to meet drivers' needs (and those of their vehicles!. (Alagia, Chiusaroli 2000; Viale 2007; Ward 1978

    And since there is an unsolvable conflict between drivers' and pedestrians' needs (and cyclists, skaters, runners, ... needs too, we can say that contemporary city is not capable of ensuring the right of pedestrians (and cyclists to safely and freely walk (and to safely and freely cycle. (Illich 2006; Labbucci 2011; Viale 2007

    Urban traffic congestion has a number of negative effects: road accidents, air pollution, noise pollution, time wastage, privatization of public spaces, limitation of the right of pedestrians (and cyclists to walk (and to cycle. All these negative effects cause a significant reduction of everyday quality of life for everyone: both people who use car and people who cannot or does not want to. (Alagia, Chiusaroli 2000; Viale 2007

    Urban planning has to guarantee the right to actually "use" the city for every and each individual, including pedestrians (and cyclists.

    To achieve this goal it is necessary to make policies aimed at reducing the overall number of cars. The engagement of people (voluntary, aware and responsible is essential to make these policies work.

    Therefore, urban planning has to deal with this issue: how can social learning be effectively enhanced to promote a cultural change in mobility behaviour?

    Until now, urban planning has mainly referred to reasons of environmental sustainability. (Viale 2007

    Results are not satisfactory. Most Italian cities are still hostile to pedestrians (and cyclists, especially to the most vulnerable groups: children, elderly people, disabled people, etc.

    Perhaps, reasons of environmental sustainability are not much effective because of their individualistic nature and since they refer especially to long term effects of actions. (Elster 1993; Illich

  20. Synchronization of Traffic Light Systems for Maximum Efficiency along Jalan Bukit Gambier, Penang, Malaysia

    OpenAIRE

    Ahmad Rafidi M.A.; Abdul Hamid A.H.

    2014-01-01

    The synchronization of traffic light systems is one of the best solutions in order to avoid problematic traffic jams. Traffic timing is a major concern when it comes to traffic management. One of the common causes of traffic jams is because of nonsynchronized traffic light systems. Once a light turns green, traffic begins to move, but by the time the moving traffic reaches the next light, the signal is still red. This will disrupt the continuity of the traffic flow, especially for large main ...

  1. Stable carbon isotope reconstruction of ungulate diet changes through the seasonal cycle

    OpenAIRE

    Codron, D.; Lee-Thorp, J A; M. Sponheimer; J. Codron

    2007-01-01

    We analysed stable carbon isotope ratios (13C) in faeces of 11 African ungulate species from three South African savanna environments to determine whether this approach is sufficiently sensitive to record short-term seasonal diet changes in browsers (BR), mixed-feeders (IM), and grazers (GR). At monthly intervals, faecal 13C revealed variations in proportions of C3 (browse) to C4 (grass) biomass consumed that were not detected by broader dry versus wet season comparisons, including subtle die...

  2. Multi-century Changes to Global Climate and Carbon Cycle: Results from a Coupled Climate and Carbon Cycle Model

    Energy Technology Data Exchange (ETDEWEB)

    Bala, G; Caldeira, K; Mirin, A; Wickett, M; Delire, C

    2005-02-17

    In this paper, we use a coupled climate and carbon cycle model to investigate the global climate and carbon cycle changes out to year 2300 that would occur if CO{sub 2} emissions from all the currently estimated fossil fuel resources were released to the atmosphere. By year 2300, the global climate warms by about 8 K and atmospheric CO{sub 2} reaches 1423 ppmv. The warming is higher than anticipated because the sensitivity to radiative forcing increases as the simulation progresses. In our simulation, the rate of emissions peak at over 30 PgC yr{sup -1} early in the 22nd century. Even at year 2300, nearly 50% of cumulative emissions remain in the atmosphere. In our simulations both soils and living biomass are net carbon sinks throughout the simulation. Despite having relatively low climate sensitivity and strong carbon uptake by the land biosphere, our model projections suggest severe long-term consequences for global climate if all the fossil-fuel carbon is ultimately released to the atmosphere.

  3. Effects of Stratospheric Ozone Depletion, Solar UV Radiation, and Climate Change on Biogeochemical Cycling: Interactions and Feedbacks

    Science.gov (United States)

    Climate change modulates the effects of solar UV radiation on biogeochemical cycles in terrestrial and aquatic ecosystems, particularly for carbon cycling, resulting in UV-mediated positive or negative feedbacks on climate. Possible positive feedbacks discussed in this assessment...

  4. 城市灯控平面交叉口慢行交通时空违章特征研究%Slow Traffic Peccancy Character for Urban Signal Intersection

    Institute of Scientific and Technical Information of China (English)

    王庆; 陈学武; 周娇; 陈琳英

    2012-01-01

    在南京市内4个典型交叉口调查数据的基础上,通过对4 000多个行人样本数据和相应交叉口不同时间段的自行车违章数据的统计分析,得出了慢行交通的时空违章特征.行人个体违章在时空违章上有不同的表现形式,在不同交叉口存在很大的差异性;行人的违章行为与性别无关,与年龄有关,少年的违章比例最低.由于交叉口断面形式、信号配时、运行秩序、交通管制、周边环境等方面的因素,自行车的行驶方向平均违章率和违章性质平均违章率在不同交叉口存在很大的差异性.针对慢行交通违章者安全意识淡薄且违章成本较低、交叉口的设计不合理等原因,提出相应的预防和纠正违章的建议和措施.%It has been drawn out from statistical analysis on 4000 sample data of the peccancy of passerby at different intersection from the four model intersection in Nanjing that there is different behave forms in time and space for passby peccancy and great difference at each crossings. It relates to passerby age, but not to sex, e. G. The peccancy rate of teen-age is the lowest. There is great difference in peccancy of run way and behavior property by analysis on differ time sect bicycle date, which is related to some factors, such as road cross-section, traffic control, run order and surrounding environment. According to the main reason of slow traffic peccancy behavior, I. E. The actor's dim safety consciousness, low cost of peccany, srrationali intersecton design, corresponding suggestions and measures to prevent and correct traffic peccancy are proposed. The behavior character of slow traffic peccancy on the city s signal intersection would be a good reference for solving the urban signal intersection mixed traffic problems.

  5. The global marine phosphorus cycle: Response to climate change and feedbacks on ocean biogeochemistry. Geologica Ultraiectina (329)

    OpenAIRE

    Tsandev, I.

    2010-01-01

    This thesis focuses on the marine phosphorus (P) cycle and its response to changing environmental conditions, particularly those associated with glacial-interglacial cycles of the late Pleistocene and Ocean Anoxic Events in the Cretaceous. From a box model of the ocean phosphorus, organic carbon and oxygen cycles, climate change scenarios are applied representing these events. The effects of continental supply of reactive P, oceanic mixing, and sea level on the marine P cycle are examined on ...

  6. Understanding the early cycling evolution behaviors for phase change memory application

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yuchan, E-mail: yuchanwang87@gmail.com; Chen, Yifeng, E-mail: yfchen@mail.sim.ac.cn; Cai, Daolin; Cheng, Yan; Chen, Xiaogang; Wang, Yueqing; Xia, Mengjiao; Zhou, Mi; Li, Gezi; Zhang, Yiyun; Gao, Dan; Song, Zhitang [State Key Laboratory of Functional Materials for Informatics and Nanotechnology Laboratory, Shanghai Institute of Micro-system and Information Technology, Chinese Academy of Sciences, Shanghai 200050 (China); Feng, Gaoming [United Lab, Semiconductor Manfacturing International Corporation, Shanghai 201203 (China)

    2014-11-28

    The RESET current of T-shaped phase change memory cells with 35 nm heating electrodes has been studied to understand the behavior of early cycling evolution. Results show that the RESET current has been significantly reduced after the early cycling evolution (1st RESET) operation. Compared the transmission electron microscope images, it is found that the hexagonal Ge{sub 2}Sb{sub 2}Te{sub 5} (GST) crystal grains are changed into the grains with face centered cubic structure after the early cycling evolution operation, which is taken as the major reason for the reduced RESET current, confirmed by a two-dimensional finite analysis and ab initio calculations.

  7. Intelligent Traffic Signal Constrol System Based on Network Technology%基于网络的智能交通信号控制系统

    Institute of Scientific and Technical Information of China (English)

    范振平; 李强

    2011-01-01

    针对城市交通控制系统的缺陷和不足,将基于网络的控制方法引入道路交通控制系统,并建立整合模糊控制和神经网络的模糊神经网络的控制模型,实现了控制系统的智能化、低成本,为现有的道路交通控制提供了一种新的解决思路.%In view of the deficiency and inadequacy of existing urban traffic control systems, the paper introduces the network-based control technology and establishes a fuzzy neural network control model which realizes intelligent control and cost reduction and provides a new perspective for road traffic regulation and control.

  8. SIGNAL DETECTION OF GLOBAL CLIMATE CHANGE AND EXTERNAL FORCING FACTORS

    Institute of Scientific and Technical Information of China (English)

    李晓东; 王在文; 侯章栓

    2001-01-01

    In this paper, we displayed one-dimensional climate signals, such as global temperature variation, Southern Oscillation Index and variation of external forcing factors, on a two-dimensional time-scale plane using compactly supported wavelet decomposition. Using the lag-correlation analysis method, and interpretative variance analysis method, and phase comparison method to the wavelet analysis result, we not only gained the variation on different scales to the global temperature and El Nino signals, the location of the jump point and intrinsic scale of these series, but also indicated the magnitude, extent and time of the effect of external forcing factors on them. We also put forward reasonable explanation to the main variation of recent 140 years.

  9. 36 CFR 504.13 - Vehicular and pedestrian traffic.

    Science.gov (United States)

    2010-07-01

    ... traffic. 504.13 Section 504.13 Parks, Forests, and Public Property SMITHSONIAN INSTITUTION RULES AND REGULATIONS GOVERNING SMITHSONIAN INSTITUTION BUILDINGS AND GROUNDS § 504.13 Vehicular and pedestrian traffic... times and shall comply with the signals and directions of the guards and all posted traffic signs....

  10. 31 CFR 91.12 - Vehicular and pedestrian traffic.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Vehicular and pedestrian traffic. 91... traffic. (a) Drivers of all vehicles in or on the property shall drive in a careful and safe manner at all times and shall comply with the signals and directions of guards and all posted traffic signs. (b)...

  11. 4 CFR 25.13 - Vehicular and pedestrian traffic.

    Science.gov (United States)

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Vehicular and pedestrian traffic. 25.13 Section 25.13... OFFICE BUILDING AND ON ITS GROUNDS § 25.13 Vehicular and pedestrian traffic. (a) Drivers of all vehicles... at all times and shall comply with all posted traffic signs and with the signals and directions...

  12. Morphine dependence and withdrawal induced changes in cholinergic signaling

    Science.gov (United States)

    Neugebauer, Nichole M.; Einstein, Emily B.; Lopez, Maria B.; McClure-Begley, Tristan D.; Mineur, Yann S.; Picciotto, Marina R.

    2013-01-01

    Cholinergic signaling is thought to be involved in morphine dependence and withdrawal, but the specific mechanisms involved remain unclear. The current study aimed to identify alterations in the cholinergic system that may contribute to the development of morphine dependence and withdrawal. Acetylcholinesterase (AChE) activity and [3H]-epibatidine binding were evaluated in order to determine if morphine dependence and withdrawal induces alterations in cholinergic signaling or expression of high affinity nicotinic acetylcholine receptors (nAChRs) in the midbrain (MB), medial habenula (MHb) and interpeduncular nucleus (IPN). The effect of cholinergic signaling through nAChRs on morphine-withdrawal induced jumping behavior was then determined. Lastly, the contribution of β4-containing nAChRs receptors in the MHb to morphine-withdrawal induced jumping behavior and neuronal activity as indicated by c-fos expression was assessed. Chronic morphine administration decreased AChE activity in MB and MHb, an effect that was no longer present following precipitated withdrawal. Morphine dependent mice showed increased nicotinic acetylcholine receptor (nAChR) levels in MB. Further, nicotine (0.4 mg/kg) and lobeline (3 mg/kg) decreased jumping behavior while mecamylamine (1 mg/kg) had no effect. Knock-down of β4 subunit-containing nAChRs in the MHb attenuated c-fos activation, but did not decrease morphine withdrawal-induced jumping. Thus, morphine withdrawal induces cholinergic signaling in the MHb, but this does not appear to be responsible for the effects of cholinergic drugs on somatic signs of opiate withdrawal, as measured by jumping behavior. PMID:23651795

  13. Interactive Effects of Urban Land Use and Climate Change on Biogeochemical Cycles (Invited)

    Science.gov (United States)

    Pouyat, R. V.

    2009-12-01

    Urban land-use change can affect biogeochemical cycles through altered disturbance regimes, landscape management practices (e.g., irrigation and fertilization), built structures, and altered environments (heat island effect, pollution, introduction of non-native species, loss of native species). As a result, the conversion of native to urban ecological systems has been shown to significantly affect carbon, nitrogen, and water cycles at local, regional, and global scales. These changes have created novel habitats and ecosystems, which have no analogue in the history of life. Nonetheless, some of the environmental changes occurring in urban areas are analogous to the changes expected in climate by the end of the century, e.g. atmospheric increase in CO2 and an increase in air temperatures, which can be utilized as a “natural experiment” to investigate global change effects on large scale ecosystem processes. Moreover, as analogues of expected future environments, urban ecological systems may act as reservoirs of plant and animal species for adjoining landscapes that are expected to undergo relatively rapid climate changes in the next 100 years. Urban land-use change by itself may contribute to changes in regional weather patterns and long-term changes in global climate, which will depend on the net effect of converting native systems to urban systems and the comparison of per capita “footprints” between urban, suburban, and rural inhabitants. My objectives are to 1) assess the impact of changes in urban land-use on climate change and in turn how climate change may affect urban biogeochemical cycles and 2) discuss the potential for urban ecosystems to mitigate green house gas emissions.

  14. Influence of Traffic Mix on PCU Value of Vehicles under Heterogeneous Traffic Conditions

    Directory of Open Access Journals (Sweden)

    Prema Somanathan Praveen

    2013-09-01

    Full Text Available Study of the basic traffic flow characteristics like traffic volume is the pre-requisites for the effective planning, design, operation and management of roadway systems. Traffic in developing countries like India is heterogeneous in nature consisting of vehicles of different categories with widely varying dimensional and operational characteristics. The moving vehicles of heterogeneous traffic occupy any convenient lateral position on the road without any lane discipline, based on the availability of space. The interaction between moving vehicles under such traffic condition is highly complex in nature, which can be represented in terms of the amount of impedance caused to flow of traffic by a vehicle type in comparison with that of standard vehicle (passenger car. Passenger Car Unit (PCU can be an appropriate measure to represent the relative impedance caused by a vehicle in heterogeneous traffic. This paper is concerned with the application micro-simulation technique to derive equivalency values (PCU factors on a purely homogeneous (cars-only traffic stream as well as on a heterogeneous traffic stream for different categories of road vehicles over a wide range of traffic flow and compositions on four-lane divided urban roads in India. The PCU values obtained for the different types of vehicles, for a wide range of traffic volume and composition, indicate that the PCU values of a vehicle type significantly changes with change in traffic volume and composition.

  15. Age and attitude: Changes in cycling patterns of different e-bike user segments

    DEFF Research Database (Denmark)

    Haustein, Sonja; Møller, Mette

    2016-01-01

    The use and purchase of electric bicycles (e-bikes) is emerging in many countries. Existing knowledge about changes in cycling patterns and car replacement after gaining e-bike access is limited and partly contradictory. Based on an online survey among e-bike users in Denmark (N = 427), this study...

  16. INTERACTIONS OF CHANGING CLIMATE AND ULTRAVIOLET RADIATION IN AQUATIC AND TERRESTRIAL BIOGEOCHEMICAL CYCLES

    Science.gov (United States)

    During the past decade interest has developed in the interactive effects of climate change and UV radiation on aquatic and terrestrial biogeochemical cycles. This talk used selected case studies to illustrate approaches that are being used to investigate these intriguing processe...

  17. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis.

    Directory of Open Access Journals (Sweden)

    Jeffrey M Skerker

    2005-10-01

    Full Text Available Two-component signal transduction systems, comprised of histidine kinases and their response regulator substrates, are the predominant means by which bacteria sense and respond to extracellular signals. These systems allow cells to adapt to prevailing conditions by modifying cellular physiology, including initiating programs of gene expression, catalyzing reactions, or modifying protein-protein interactions. These signaling pathways have also been demonstrated to play a role in coordinating bacterial cell cycle progression and development. Here we report a system-level investigation of two-component pathways in the model organism Caulobacter crescentus. First, by a comprehensive deletion analysis we show that at least 39 of the 106 two-component genes are required for cell cycle progression, growth, or morphogenesis. These include nine genes essential for growth or viability of the organism. We then use a systematic biochemical approach, called phosphotransfer profiling, to map the connectivity of histidine kinases and response regulators. Combining these genetic and biochemical approaches, we identify a new, highly conserved essential signaling pathway from the histidine kinase CenK to the response regulator CenR, which plays a critical role in controlling cell envelope biogenesis and structure. Depletion of either cenK or cenR leads to an unusual, severe blebbing of cell envelope material, whereas constitutive activation of the pathway compromises cell envelope integrity, resulting in cell lysis and death. We propose that the CenK-CenR pathway may be a suitable target for new antibiotic development, given previous successes in targeting the bacterial cell wall. Finally, the ability of our in vitro phosphotransfer profiling method to identify signaling pathways that operate in vivo takes advantage of an observation that histidine kinases are endowed with a global kinetic preference for their cognate response regulators. We propose that this

  18. Using the moving synchronous average to analyze fuzzy cyclostationary signals

    OpenAIRE

    Leclere, Q.; Hamzaoui, Nacer

    2014-01-01

    International audience Cyclostationarity is a property of vibration and acoustic signals recorded on rotating machines operating at constant speed. It states that the statistic properties of signals are periodic: the random process defined by the signal observed at a given position in the cycle is stationary, the cycle being defined as the angle interval between two identical configurations of the mechanical system. Cyclostationarity is not fully satisfied if the signals are acquired in the ti...

  19. Characteristics of vehicular traffic flow at a roundabout

    Science.gov (United States)

    Ebrahim Fouladvand, M.; Sadjadi, Zeinab; Reza Shaebani, M.

    2004-10-01

    We construct a stochastic cellular automata model for the description of vehicular traffic at a roundabout designed at the intersection of two perpendicular streets. The vehicular traffic is controlled by a self-organized scheme in which traffic lights are absent. This controlling method incorporates a yield-at-entry strategy for the approaching vehicles to the circulating traffic flow in the roundabout. Vehicular dynamics is simulated and the delay experienced by the traffic at each individual street is evaluated. We discuss the impact of the geometrical properties of the roundabout on the total delay. We compare our results with traffic-light signalization schemes, and obtain the critical traffic volume over which the intersection is optimally controlled through traffic-light signalization schemes.

  20. Gulf of Mexico Climate, Laurentide Ice Sheet History, and Global Sea Level Change During the Last Glacial Cycle

    Science.gov (United States)

    Flower, B. P.; Williams, C.; Brown, E. A.; Hastings, D. W.; Hill, H.; Adams, S.; Hendrix, J.; Martin, E. E.; Biller, N. B.; Goddard, E.

    2011-12-01

    The interactions between low-latitude Atlantic climate and high-latitude ice sheet variability represent an important issue in past abrupt climate change. Specifically, Laurentide Ice Sheet (LIS) meltwater input seems to be decoupled at the millennial scale from Gulf of Mexico sea-surface temperature (SST), as well as Greenland air temperature, during the last glacial cycle. Indeed, comparison to Greenland ice core records indicate significant meltwater input during some North Atlantic cool episodes, including Heinrich Stadials 4, 3, and 1. Here we present published and new Mg/Ca and δ18O data on the planktic foraminifer Globigerinoides ruber from northern Gulf of Mexico sediment cores that provide detailed records of SST, δ18O of seawater (δ18Osw), and inferred salinity for the 48-10 ka interval. Age control for Orca Basin cores MD02-2550 and -2551 is based on AMS 14C dates on G. ruber and documents continuous sedimentation at rates >35 cm/kyr. Significant meltwater input is inferred from δ18Osw data during Antarctic Isotope Maxima (AIM) events and reaches a peak during the Bølling/Allerød, consistent with bipolar warming and a high sensitivity to greenhouse forcing. Furthermore, bulk sediment δ18O data show a brief spike reaching -5.5% ca. 14.5 ka during an interval barren of foraminifera. We speculate that this excursion represents fine carbonate sediment from Canadian Paleozoic marine carbonates, analogous to detrital carbonate in the North Atlantic that has a δ18O value of -5%. Radiogenic isotope data (Nd and Pb) also reach peak values at this interval, indicative of older continental material sourced from Canada vs. younger material from the Mississippi River drainage basin. Inferred major meltwater flow appears to have been associated with meltwater pulse 1a within the Bølling warm interval, consistent with a significant contribution by the LIS to rapid global sea level rise. Overall, the relations between Gulf of Mexico meltwater input, Heinrich

  1. Calibrating Car Following Parameters for Snowy Road Conditions in the Microscopic Traffic Simulator VISSIM

    NARCIS (Netherlands)

    Asamer, J.; Van Zuylen, H.J.; Heilmann, B.

    2013-01-01

    Calibrated simulation models taking into account adverse weather conditions can be used to optimise traffic management strategies, such as speed adaptation and signal timing optimisation. On snowy road conditions, car following behaviour changes because drivers tend to accelerate more slowly, increa

  2. Evaluating the impacts of climate change on diurnal wind power cycles using multiple regional climate models

    KAUST Repository

    Goddard, Scott D.

    2015-05-01

    Electrical utility system operators must plan resources so that electricity supply matches demand throughout the day. As the proportion of wind-generated electricity in the US grows, changes in daily wind patterns have the potential either to disrupt the utility or increase the value of wind to the system over time. Wind power projects are designed to last many years, so at this timescale, climate change may become an influential factor on wind patterns. We examine the potential effects of climate change on the average diurnal power production cycles at 12 locations in North America by analyzing averaged and individual output from nine high-resolution regional climate models comprising historical (1971–1999) and future (2041–2069) periods. A semi-parametric mixed model is fit using cubic B-splines, and model diagnostics are checked. Then, a likelihood ratio test is applied to test for differences between the time periods in the seasonal daily averaged cycles, and agreement among the individual regional climate models is assessed. We investigate the significant changes by combining boxplots with a differencing approach and identify broad categories of changes in the amplitude, shape, and position of the average daily cycles. We then discuss the potential impact of these changes on wind power production.

  3. Characterization of mortality rates resulting from traffic accidents involving cycles Caracterización de la mortalidad por accidentes del tránsito con participación de ciclos

    Directory of Open Access Journals (Sweden)

    Mavis Ortis Sagasta

    2010-08-01

    Full Text Available Background: Traffic accidents are a highly complex phenomenon due to the variety of factors involved in their occurrence. They have become more relevant as the fight against illnesses becomes more effective. Objective: To characterize the mortality rates resulting from traffic accidents involving cycles. Methods: Descriptive study on case series conducted at the General University Hospital "Dr. Gustavo Lima Aldereguía " in Cienfuegos on all deaths related to traffic accidents involving cycles from January 1st to December 31st , 2009. Variables that were analyzed: age, sex, time of the accident, predominantly affected anatomical region, direct cause of death and ingestion of alcohol. Results: There were 26 deaths (6.4 per 100 000 inhabitants, mainly in the group from 15 to 29 years old, predominantly males with 23 cases (88.4%.53, 8% of them were workers and 23% were students. There was a predominance of fatalities in the hours between 6:00 pm and 11:59 pm. The most affected anatomic region was the head (61.5%, 46, 2 % of deaths had more than 50 mg of alcohol in blood and the predominant direct cause of death was the injuries of higher nervous centers. Conclusions: Traffic accidents involving cycles are more frequent in young males . They are related to the ingestion of alcohol and usually affect the head region.Introducción: los accidentes constituyen un fenómeno sumamente complejo debido a los numerosos y variados factores que intervienen en su producción. Estos se hacen más relevantes en la medida que se hace más eficaz la lucha contra las enfermedades. Objetivo: caracterizar la mortalidad por accidentes de tránsito con participación de ciclos. Métodos: estudio descriptivo de serie de casos, realizado en el Hospital General Universitario “Dr. Gustavo Aldereguía Lima” de Cienfuegos sobre todos los

  4. Aging in autonomic control by multifractal studies of cardiac interbeat intervals in the VLF band

    International Nuclear Information System (INIS)

    The heart rate responds dynamically to various intrinsic and environmental stimuli. The autonomic nervous system is said to play a major role in this response. Multifractal analysis offers a novel method to assess the response of cardiac interbeat intervals. Twenty-four hour ECG recordings of RR interbeat intervals (of 48 elderly volunteers (age 65–94), 40 middle-aged persons (age 45–53) and 36 young adults (age 18–26)) were investigated to study the effect of aging on autonomic regulation during normal activity in healthy adults. Heart RR-interval variability in the very low frequency (VLF) band (32–420 RR intervals) was evaluated by multifractal tools. The nocturnal and diurnal signals of 6 h duration were studied separately. For each signal, the analysis was performed twice: for a given signal and for the integrated signal. A multifractal spectrum was quantified by the hmax value at which a multifractal spectrum attained its maximum, width of a spectrum, Hurst exponent, extreme events hleft and distance between the maxima of a signal and its integrated counterpart. The following seven characteristics are suggested as quantifying the age-related decrease in the autonomic function ('int' refers to the integrated signal): (a) hsleepmax − hmaxwake > 0.05 for a signal; (b) hintmax > 1.15 for wake; (c) hintmax − hmax > 0.85 for sleep; (d) Hurstwake − Hurstsleep < 0.01; (e) widthwake > 0.07; (f) widthint < 0.30 for sleep; (g) hintleft > 0.75. Eighty-one percent of elderly people had at least four of these properties, and ninety-two percent of young people had three or less. This shows that the multifractal approach offers a concise and reliable index of healthy aging for each individual. Additionally, the applied method yielded insights into dynamical changes in the autonomic regulation due to the circadian cycle and aging. Our observations support the hypothesis that imbalance in the autonomic control due to healthy aging could be related to

  5. OPTIMIZATION OF URBAN MULTI-INTERSECTION TRAFFIC FLOW VIA Q-LEARNING

    OpenAIRE

    Yit Kwong Chin; Heng Jin Tham; N.S.V. Kameswara Rao; Nurmin Bolong; Kenneth Tze Kin Teo

    2013-01-01

    Congestions of the traffic flow within the urban traffic network have been a challenging task for all the urban developers. Many approaches have been introduced into the current system to solve the traffic congestion problems. Reconfiguration of the traffic signal timing plan has been carried out through implementation of different techniques. However, dynamic characteristics of the traffic flow increase the difficulties towards the ultimate solutions. Thus, traffic congestions still remain a...

  6. A Sarsa(λ)-Based Control Model for Real-Time Traffic Light Coordination

    OpenAIRE

    Xiaoke Zhou; Fei Zhu; Quan Liu; Yuchen Fu; Wei Huang

    2014-01-01

    Traffic problems often occur due to the traffic demands by the outnumbered vehicles on road. Maximizing traffic flow and minimizing the average waiting time are the goals of intelligent traffic control. Each junction wants to get larger traffic flow. During the course, junctions form a policy of coordination as well as constraints for adjacent junctions to maximize their own interests. A good traffic signal timing policy is helpful to solve the problem. However, as there are so many factors t...

  7. Calcium and calcium isotope changes during carbon cycle perturbations at the end-Permian

    Science.gov (United States)

    Komar, Nemanja; Zeebe, Richard

    2016-04-01

    Negative carbon and calcium isotope excursions, as well as climate shifts, took place during the most severe mass extinction event in Earth's history, the end-Permian (˜252 Ma). Investigating the connection between carbon and calcium cycles during transient carbon cycle perturbation events, such as the end-Permian, may help resolve the intricacies between the coupled calcium-carbon cycles, as well as provide a tool for constraining the causes of mass extinction. Here, we identify the deficiencies of a simplified calcium model employed in several previous studies and we demonstrate the importance of a fully coupled carbon-cycle model when investigating the dynamics of carbon and calcium cycling. Simulations with a modified version of the LOSCAR model, which includes a fully coupled carbon-calcium cycle, indicate that increased weathering rates and ocean acidification (potentially caused by Siberian Trap volcanism) are not capable of producing trends observed in the record, as previously claimed. Our model results suggest that combined effects of carbon input via Siberian Trap volcanism (12,000 Pg C), the cessation of biological carbon export, and variable calcium isotope fractionation (due to a change in the seawater carbonate ion concentration) represents a more plausible scenario. This scenario successfully reconciles δ13C and δ44Ca trends observed in the sediment record, as well as the proposed warming of >6oC.

  8. Sexual desire changes during menstrual cycle and relationship with premenstrual syndrome

    Directory of Open Access Journals (Sweden)

    Kiani Asiabar A.

    2007-09-01

    Full Text Available Background: Sexual function in women may be affected by their menstrual cycle. Lack of sexual drive is a deficiency or absence of sexual fantasies and desire for sexual activity. This study aims at determining the changes in sexual desire during the menstrual cycle and those associated with premenstrual syndrome (PMS and evaluates sexual desire during the menstrual cycle and the associated changes with PMS. Methods: The sample for this cross-sectional study includes 150 women employed in factories in Tehran. The instruments for data collection were questionnaires and journals of premenstrual experiences.Results: Analysis of the data showed that the mean age of the subjects was 31 years standard deviation = 8.46(. The most frequent decrease in sexual desire was during the week prior to the start of menstrual bleeding (27.3% and the least frequent was from the end of bleeding to one week before the next period of menstrual bleeding (5.3%. In 24.7% of the cases, an increase in sexual desire occurred during the middle of the menstrual cycle and 27.3% during the course of menstrual bleeding. Moreover, 10.7% of the subjects had an increase in sexual desire during the week before bleeding. Furthermore, a positive correlation was found between changes in sexual desire and PMS (p<0.001. In addition, a positive correlation was found between changes in sexual desire and breast tenderness, joint and muscle pain. Conclusions: The sexual desire of women, with or without PMS, changes during the menstrual cycle. The greatest decrease in sexual desire occurs during the first week before menstrual bleeding in women with PMS. Such information can greatly help toward understanding and treatment in sexual therapy for couples.

  9. Weight loss and body composition changes following three sequential cycles of ketogenic enteral nutrition

    Directory of Open Access Journals (Sweden)

    Gianfranco Cappello

    2012-01-01

    Full Text Available Background: Ketogenic enteral nutrition (KEN is a modification of the protein sparing modified fast in which a protein solution is introduced with a continuous infusion through a nasogastric tube over 10-days cycles. The aim of the study was to perform a retrospective analysis of the safety, compliance, weight loss and body composition changes after 3 sequential 10-days cycles of KEN therapy. Materials and Methods: From a large number of patients who underwent KEN therapy in our department over a 5-year period, we selected 188 patients who participated in 3 KEN cycles with 10-13 days of break between them. Before and after the treatment cycles, body composition was analyzed by bioelectric impedance; a final assessment was made 10 days after the end of last cycle. During each rest period all the patients were on a low-carbohydrate, normal caloric diet. Results: Most patients (97% successfully tolerated the nasogastric treatment and lost an average of 14.4 kg of body weight, 10.6 kg of fat mass and 3.4 kg of body cell mass. Adverse effects were recorded as mild gastric hypersecretion (2% and constipation (5%. Patients continued to lose fat during the 10-day follow up period after the end of each KEN Cycle. This effect may be explained by abnormality of water distribution during the rapid weight loss inducing the observed change in fat mass. Conclusion: Ten-days KEN treatment cycles can induce rapid weight loss and reduction of fat mass in obese patients. Furthermore, preservation of lean mass can be achieved by infusing 1.9 g of protein/kg of BCM.

  10. The impact of traffic volume, composition, and road geometry on personal air pollution exposures among cyclists in Montreal, Canada.

    Science.gov (United States)

    Hatzopoulou, Marianne; Weichenthal, Scott; Dugum, Hussam; Pickett, Graeme; Miranda-Moreno, Luis; Kulka, Ryan; Andersen, Ross; Goldberg, Mark

    2013-01-01

    Cyclists may experience increased exposure to traffic-related air pollution owing to increased minute ventilation and close proximity to vehicle emissions. The aims of this study were to characterize personal exposures to air pollution among urban cyclists and to identify potential determinants of exposure including the type of cycling lane (separated vs on-road), traffic counts, and meteorological factors. In total, personal air pollution exposure data were collected over 64 cycling routes during morning and evening commutes in Montreal, Canada, over 32 days during the summer of 2011. Measured pollutants included ultrafine particles (UFPs), fine particles (PM(2.5)), black carbon (BC), and carbon monoxide (CO). Counts of diesel vehicles were important predictors of personal exposures to BC, with each 10 vehicle/h increase associated with a 15.0% (95% confidence interval (CI): 5.7%, 24.0%) increase in exposure. Use of separated cycling lanes had less impact on personal exposures with a 12% (95% CI: -43%, 14%) decrease observed for BC and smaller decreases observed for UFPs (mean: -1.3%, 95% CI: -20%, 17%) and CO (mean: -5.6%, 95% CI: -17%, 4%) after adjusting for meteorological factors and traffic counts. On average, PM(2.5) exposure increased 7.8% (95% CI: -17%, 35%) with separate cycling lane use, but this estimate was imprecise and not statistically significant. In general, our findings suggest that diesel vehicle traffic is an important contributor to personal BC exposures and that separate cycling lanes may have a modest impact on personal exposure to some air pollutants. Further evaluation is required, however, as the impact of separate cycling lanes and/or traffic counts on personal exposures may vary between regions.

  11. Effects of Land Use Change on C-N cycling: Microbes Matter.

    Science.gov (United States)

    Hofmockel, K.

    2012-12-01

    Large swaths of the terrestrial landscape have been altered by human actions on Earth's biophysical systems, resulting in the homogenization of Earth's biota, while simultaneously increasing greenhouse gases and reactive nitrogen (N). This is especially poignant in grasslands that have been largely replaced by managed agricultural systems with substantial N inputs, or by unmanaged grasslands that are dominated by exotic species. Impacted ecosystems may be important for global C models, because they comprise a major portion of the global land area, terrestrial NPP and the world's soil C stocks. This research investigates how anthropogenic changes in plant community composition and agricultural management systems influence the composition and function of microbial communities that mediate key aspects of belowground C and N cycling and storage. Data from agroecology and grassland climate change experiments are used to illustrate how microbial responses can have important implications for large scale coupling of C and N cycles. In this study exotic plant species significantly decreased root inputs, causing shifts in microbial community composition, including both specific taxa and functional guilds of bacteria. By contrast, climate change (precipitation manipulation) caused functional responses (increased carbon and phosphorus cycling) that were not detected in the microbial community composition. Mycorrhizal fungi in managed systems were responsive to both root biomass and nitrogen inputs, significantly altering hydrolytic enzyme activity and aggregate turnover. Collectively small-scale processes can alter the ecosystem biogeochemical cycles. Together theses results suggest that linking microbial communities to coupled C-N cycles may have important implications for terrestrial C cycling feedbacks that are an integral part of the anthropocene era.

  12. The Physics of Traffic

    Science.gov (United States)

    Davis, L. Craig

    2006-03-01

    Congestion in freeway traffic is an example of self-organization in the language of complexity theory. Nonequilibrium, first-order phase transitions from free flow cause complex spatiotemporal patterns. Two distinct phases of congestion are observed in empirical traffic data--wide moving jams and synchronous flow. Wide moving jams are characterized by stopped or slowly moving vehicles within the jammed region, which widens and moves upstream at 15-20 km/h. Above a critical density of vehicles, a sudden decrease in the velocity of a lead vehicle can initiate a transition from metastable states to this phase. Human behaviors, especially delayed reactions, are implicated in the formation of jams. The synchronous flow phase results from a bottleneck such as an on-ramp. Thus, in contrast to a jam, the downstream front is pinned at a fixed location. The name of the phase comes from the equilibration (or synchronization) of speed and flow rate across all lanes caused by frequent vehicle lane changes. Synchronous flow occurs when the mainline flow and the rate of merging from an on-ramp are sufficiently large. Large-scale simulations using car-following models reproduce the physical phenomena occurring in traffic and suggest methods to improve flow and mediate congestion.

  13. Traffic Route Modelling and Assignment with Intelligent Transport System

    OpenAIRE

    Kunicina Nadezhda; Galkina Alina; Zabasta Anatolijs; Patlins Antons; Kondratjevs Kaspars

    2014-01-01

    The development of signal transmitting environment for multimodal traffic control will enhance the integration of emergency and specialized transport routing tools in usual traffic control paradigms - it is one of the opportunities offered by modern intelligent traffic control systems. The improvement of effective electric power use in public transport system is an advantage of Intelligent Transport System (ITS). The research is connected with the improvement of on-line traffic control and ad...

  14. Study on Driver Visual Physiological Characteristics in Urban Traffic

    OpenAIRE

    Fengyuan Wang; Min Li; Jieyu Fan; Fuquan Pan

    2014-01-01

    In the integrated traffic environment, human factor is always a main factor of the three elementary factors, besides the vehicle and road factor. The driver physiological and psychological characteristics have an important impact especially on traffic safety in urban road traffic conditions . Some typical traffic scenes in condition of urban road, such as light signal control at intersection, overtaking, and passing, are selected for condition analysis. An eye movement apparatus was used to o...

  15. Data Fusion in Road Traffic Engineering: An overview

    OpenAIRE

    EL-FAOUZI, NE

    2004-01-01

    The objective of this paper is to present an analysis of recent applications of data fusion (DF) in road traffic engineering. First, we report the most significant applications of data fusion techniques in road traffic engineering area: traffic monitoring, signal control, Automatic Incident Detection, traffic forecasting, Intelligent Transportation Systems ..., as well as the extent and direction of DF interest in the field. Second, a classification including applications, fusion goalsand mat...

  16. Influence of Link Flow and Traffic Signal Control on the Forecast of Travel Time%流量和信号控制对运行时间预测的影响

    Institute of Scientific and Technical Information of China (English)

    徐丽群; 杨兆升; 管德永

    2001-01-01

    通过对实际交通状况的分析,说明路线运行时间不仅是路线交通流量的函数,而且是由于交叉口信号控制引起延误的函数。%The use of ATIS (Advanced Traveler Information Systems) for urban traffic management means that tripmakers can get in real time the pre-trip information and en-route information to ch oose the optimal route and reduce their travel time. Hence, reliable and frequently updated travel time information is the basis of effec tive implementation of ATIS. This paper proposes the method of foreca sting travel time at signalized network and concludes that travel time is not only the function of flow but also the function of delay caused by signal control at intersection.

  17. Pedicle marrow signal intensity changes in the lumbar spine: a manifestation of facet degenerative joint disease

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, J.L.; Kaplan, P.A.; Dussault, R.G.; Anderson, M.W. [Dept. of Radiology, Univ. of Virginia Health System, Charlottesville, VA (United States)

    2000-12-01

    Objective. Signal intensity changes in lumbar pedicles, similar to those described in vertebral body endplates adjacent to degenerated discs, have been described as an ancillary sign of spondylolysis on MRI. The purpose of this study was to determine whether pedicle marrow signal intensity changes also occur in association with facet degenerative joint disease.Design. Eighty-nine lumbar spine MRI examinations without spondylolysis were reviewed for marrow signal intensity changes in pedicles and vertebral bodies as well as for facet degenerative joint disease.Results. Five percent (46/890) of lumbar pedicles in 23 patients had marrow signal intensity changes. Ninety-one percent (42/46) of the abnormal pedicles had adjacent degenerative joint disease of the facets, while only 21% (189/890) of normal pedicles had adjacent facet degenerative joint disease (p<0.001). Eighty-nine percent (41/46) of the pedicles with marrow signal intensity changes had adjacent degenerative disc disease.Conclusions. Pedicle marrow signal intensity changes are not a specific sign of spondylolysis; they are commonly seen with adjacent facet degenerative joint disease in the absence of spondylolysis. Pedicle marrow signal intensity changes are probably a response to abnormal stresses related to abnormal motion or loading caused by the degenerative changes in the spinal segment. (orig.)

  18. Increased STAT5 signaling in the ring dove brain in response to prolactin administration and spontaneous elevations in prolactin during the breeding cycle.

    Science.gov (United States)

    Buntin, John D; Buntin, Linda

    2014-05-01

    Prolactin acts on target cells in the central nervous system (CNS) to stimulate behavioral changes associated with parental care in birds, but the signaling mechanisms that mediate these actions have not been characterized. In mammals, the Janus Kinase 2-Signal Transducer and Activator of Transcription 5 (JAK2-STAT5) signaling pathway mediates many of the actions of prolactin. To assess the importance of this pathway in prolactin-sensitive target cells in the avian brain, we measured changes in activated (phosphorylated) STAT5 (pSTAT5) in the forebrain of female ring doves sampled as plasma prolactin levels change during the breeding cycle and in prolactin-treated, non-breeding females. The anatomical distribution of cells exhibiting pSTAT5 immunoreactivity in dove brain closely paralleled the distribution of prolactin receptors in this species. The density of pSTAT5 immunoreactive (pSTAT5-ir) cells was highest in the preoptic area, the suprachiasmatic, paraventricular, and ventromedial hypothalamic nuclei, the lateral and tuberal hypothalamic regions, the lateral bed nucleus of the stria terminalis, and the lateral septum. Mean pSTAT5-ir cell densities in these eight brain areas were several fold higher in breeding females during late incubation/early post-hatching when plasma prolactin levels have been observed to peak than in non-breeding females or breeding females sampled at earlier stages when prolactin titers have been reported to be lower. Similar differences were observed between prolactin-treated and vehicle-treated females in all three of the forebrain regions that were compared. We conclude that JAK2-STAT5 signaling is strongly activated in response to prolactin stimulation in the ring dove brain and could potentially mediate some of the centrally-mediated behavioral effects of this hormone.

  19. Matching Lithosphere velocity changes to the GOCE gravity signal

    Science.gov (United States)

    Braitenberg, Carla

    2016-07-01

    Authors: Carla Braitenberg, Patrizia Mariani, Alberto Pastorutti Department of Mathematics and Geosciences, University of Trieste Via Weiss 1, 34100 Trieste Seismic tomography models result in 3D velocity models of lithosphere and sublithospheric mantle, which are due to mineralogic compositional changes and variations in the thermal gradient. The assignment of density is non-univocal and can lead to inverted density changes with respect to velocity changes, depending on composition and temperature. Velocity changes due to temperature result in a proportional density change, whereas changes due to compositional changes and age of the lithosphere can lead to density changes of inverted sign. The relation between velocity and density implies changes in the lithosphere rigidity. We analyze the GOCE gradient fields and the velocity models jointly, making simulations on thermal and compositional density changes, using the velocity models as constraint on lithosphere geometry. The correlations are enhanced by applying geodynamic plate reconstructions to the GOCE gravity field and the tomography models which places today's observed fields at the Gondwana pre-breakup position. We find that the lithosphere geometry is a controlling factor on the overlying geologic elements, defining the regions where rifting and collision alternate and repeat through time. The study is carried out globally, with focus on the conjugate margins of the African and South American continents. The background for the study can be found in the following publications where the techniques which have been used are described: Braitenberg, C., Mariani, P. and De Min, A. (2013). The European Alps and nearby orogenic belts sensed by GOCE, Boll. Bollettino di Geofisica Teorica ed Applicata, 54(4), 321-334. doi:10.4430/bgta0105---- Braitenberg, C. and Mariani, P. (2015). Geological implications from complete Gondwana GOCE-products reconstructions and link to lithospheric roots. Proceedings of 5th

  20. G-quadruplex − based homogenous fluorescence platform for ultrasensitive DNA detection through isothermal cycling and cascade signal amplification

    International Nuclear Information System (INIS)

    We describe a simple and homogenous fluorimetric method for sensitive determination of DNA. It is based on target-triggered isothermal cycling and a cascade exponential amplification reaction that generates a large amount of a G-quadruplex. This results in strong fluorescence signal when using thioflavin T as a G-quadruplex-specific light-up fluorescent probe. Tedious handling after amplification is widely eliminated by the addition of thioflavin T. No other exogenous reagent is required. This detection platform is inexpensive and rapid, and displays high sensitivity for target DNA, with a detection limit as low as 91 pM. (author)