WorldWideScience

Sample records for chalones

  1. Chalon/Saint-Marcel manufacturing plant

    International Nuclear Information System (INIS)

    AREVA is the world leader in the design and construction of nuclear power plants, the manufacture of heavy components, and the supply of nuclear fuel and nuclear services such as maintenance and inspection. The Equipment Division provides the widest range of nuclear components and equipment, manufactured at its two facilities in Jeumont, northern France, and St. Marcel, in Burgundy. The St. Marcel plant, set on 35 ha (87.5 acres) near Chalon-sur-Saone, was established in 1973 in a region with a long history of specialized metalworking and mechanical activities to meet the demand for non-military nuclear requirements in France. The site offers two advantages: - excellent facilities for loading and transporting heavy components on the Saone river, - it's proximity to other group sites. Since its completion in 1975, the Chalon/St. Marcel facility has manufactured all the heavy components for French pressurized water reactors (PWRs) ranging from 900 MW to 1500 MW. It has also completed a significant number of export contracts that have made AREVA world leader. Nearly 600 heavy components (reactor vessels, steam generators, pressurizers and closure heads) have been manufactured or are currently being manufactured since the plant opened in 1975. The plant is at the heart of the manufacturing chain for nuclear steam supply systems (NSSS) supplied by AREVA. On the basis of engineering data, the plant manufactures reactor vessels, reactor vessel internals, steam generators, pressurizers and related components such as accumulators, auxiliary heat exchangers and supporting elements. Vessel upper internals Other similar components such as reactor vessels for boiling water reactors (BWR) or high temperature reactors (HTR) and other types of steam generators can also be manufactured in the plant (for example Once Through Steam Generators - OTSG). The basic activities performed at Chalon/St. Marcel are metalworking and heavy machining. These activities are carried out in strict

  2. Chalon/Saint-Marcel manufacturing plant; L'usine de Chalon/Saint-Marcel

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    AREVA is the world leader in the design and construction of nuclear power plants, the manufacture of heavy components, and the supply of nuclear fuel and nuclear services such as maintenance and inspection. The Equipment Division provides the widest range of nuclear components and equipment, manufactured at its two facilities in Jeumont, northern France, and St. Marcel, in Burgundy. The St. Marcel plant, set on 35 ha (87.5 acres) near Chalon-sur-Saone, was established in 1973 in a region with a long history of specialized metalworking and mechanical activities to meet the demand for non-military nuclear requirements in France. The site offers two advantages: - excellent facilities for loading and transporting heavy components on the Saone river, - it's proximity to other group sites. Since its completion in 1975, the Chalon/St. Marcel facility has manufactured all the heavy components for French pressurized water reactors (PWRs) ranging from 900 MW to 1500 MW. It has also completed a significant number of export contracts that have made AREVA world leader. Nearly 600 heavy components (reactor vessels, steam generators, pressurizers and closure heads) have been manufactured or are currently being manufactured since the plant opened in 1975. The plant is at the heart of the manufacturing chain for nuclear steam supply systems (NSSS) supplied by AREVA. On the basis of engineering data, the plant manufactures reactor vessels, reactor vessel internals, steam generators, pressurizers and related components such as accumulators, auxiliary heat exchangers and supporting elements. Vessel upper internals Other similar components such as reactor vessels for boiling water reactors (BWR) or high temperature reactors (HTR) and other types of steam generators can also be manufactured in the plant (for example Once Through Steam Generators - OTSG). The basic activities performed at Chalon/St. Marcel are metalworking and heavy machining. These activities are carried out in

  3. Combined use of cyclophosphamide and Chalone 19-peptide in experimental breast cancer

    OpenAIRE

    Huang Y; He Y; Ye S; Li X; Zhong Q; Chen Z; Jin X

    2013-01-01

    Yuanxi Huang,1,* Yan He,2,* Shengqian Ye,2 Xiaomei Li,1 Qingqi Zhong,1 Zhuo Chen,1 Xiaoming Jin21Third Affiliated Hospital, 2Department of Pathology, Harbin Medical University, Harbin, Heilongjiang, People's Republic of China*These authors contributed equally to this workBackground: Cyclophosphamide is a potent anticancer drug, but its clinical utility is limited because of its severe side effects, in particular liver damage. Chalone 19-peptide induces apoptosis of tumor cells and inh...

  4. Areva, Chalon/St-Marcel site, Environment, social and societal report for 2010-2011

    International Nuclear Information System (INIS)

    After a brief indication of Areva's activities and a map locating Areva's implantations, and the distribution of turnover and personnel in the different continents, a brief recall of safety commitments, and a presentation of the activity of the Reactors and Services Business Group (turnover, personnel, number of reactors in charge), this report briefly presents the different AREVA sites in Burgundy, and more precisely the Chalon/St-Marcel site which comprises a technical centre and a plant of production of heavy components. The activities of the technical centre concern welding technology, nuclear fusion, corrosion and chemistry, fluid and structure mechanics, and technologies related to the development of new energies and to the environment. Fields of intervention and clients are evoked. The activity of the plant of production of heavy components (vapor generators, pressurizers, vessels, etc.) and some characteristics of these components are presented. The environmental aspect is then addressed: evolution of resource consumption (gas, water, electricity, paper), and of releases (greenhouse gases, used waters, waste management). The social aspect comprises social relationships, health (involved actors, prevention, safety, evolution of labour accidents), ability and job management (training, career management, education). The societal commitments have been acknowledged by several labels related to social inclusion and local activities, support of sporting and cultural activities

  5. An attempt to distinguish a modified genetic response of the mouse testis to X-ray exposure by the action of a spermatogonial chalone

    International Nuclear Information System (INIS)

    The results of an experiment designed to distinguish whether the action of a spermatogonial chalone in the mouse testis could modify the genetic response of a depleted stem spermatogonial population to X-radiation are reported. The results are consistent with the view that the stem cell population of the depleted adult testis a few days after damage closely approximates that of the early post-natal or immature animal, do not provide any indication that the testis extract in any way influence the response of the depleted testis to the 500-rad challenging dose. The yield of genetic damage was almost identical to that in the two control groups and the sterile period and testis weight data provided little reason to suspect that the amount of spermatogonial killing was altered. (Auth.)

  6. Une nouvelle épitaphe latine découverte à Chalon-sur-Saône (Cabillonum, cité des Éduens) : à propos des monuments funéraires et de l’onomastique en pays éduen

    OpenAIRE

    Fernoux, Henri-Louis; Mathieu, Nicolas

    2008-01-01

    La publication d’une épitaphe inédite découverte en 2003 dans l’enceinte romaine de Chalon-sur-Saône permet de faire provisoirement le point sur le corpus des monuments funéraires du Chalonnais et offre de nouveaux éclairages sur l’onomastique et les courants de population dans le pays éduen à la fin du IIe siècle ap. J.-C. Ce nouveau document, stèle du type le plus simple, que le formulaire permet de situer dans la période 150 - 200 ap. J.-C., fournit la nomenclature de deux pérégrins probab...

  7. Maintenance personnel training in nuclear engineering from Chalon-sur-Saone to Zwentendorf

    International Nuclear Information System (INIS)

    Analyses of the VGB Working Panel 'Maintenance Manager Workshop ' have shown that, for various reasons, the demand for training possibilities for maintenance personnel in nuclear power plants had already started increasing years ago. Different solutions - also from foreign countries - were examined, and the combined efforts of the panel members of VGB PowerTech, the PowerTech Training Center and Areva yielded a comprehensive program (hard- and software) for the German plants that is able to fulfil the basic training needs for maintenance personnel in nuclear power plants, combining theoretical as well as practical parts. (orig.)

  8. Preface to Vegetation-climate-atmosphere interactions: past, present and future, the proceedings of a Discussion Meeting held at the Royal Society

    OpenAIRE

    D. J. Beerling

    1998-01-01

    Preface to Vegetation-climate-atmosphere interactions: past, present and future, the proceedings of a Discussion Meeting held at the Royal Society. Organized and edited by D. J. Beerling, W. G. Chaloner and F. I. Woodward.

  9. Growth and chemical composition of chicory and performance of lambs grazing chicory relative to grass–clover mixtures

    OpenAIRE

    Kidane, Alemayehu; Sørheim, Kristin; Eik, Lars Olav; Steinshamn, Håvard

    2014-01-01

    We report results from trials on chicory growth (experiment 1) and lamb growth on chicory (experiment 2). In experiment 1, we assessed yield and chemical composition on swards established under organic conditions as perennial ryegrass/red clover, perennial ryegrass/chicory, chicory/red clover (CHRC), pure perennial ryegrass (RG-alone) and pure chicory (CHalone) over two years. Chicory/red clover and CH-alone showed improved crude protein, Ca, Mg, P, Cu and net energy contents comp...

  10. Newton and the counterfeiter the unknown detective career of the world's greatest scientist

    CERN Document Server

    Levenson, Thomas

    2010-01-01

    In 1695, Isaac Newton—already renowned as the greatest mind of his age—made a surprising career change. He left quiet Cambridge, where he had lived for thirty years and made his earth-shattering discoveries, and moved to London to take up the post of Warden of His Majesty's Mint. Newton was preceded to the city by a genius of another kind, the budding criminal William Chaloner. Thanks to his preternatural skills as a counterfeiter, Chaloner was rapidly rising in London's highly competitive underworld, at a time when organized law enforcement was all but unknown and money in the modern sense wa

  11. Newton and the counterfeiter the unknown detective career of the world's greatest scientist

    CERN Document Server

    Levenson, Thomas

    2010-01-01

    In 1695, Isaac Newton-already renowned as the greatest mind of his age-made a surprising career change. He left quiet Cambridge, where he had lived for thirty years and made his earth-shattering discoveries, and moved to London to take up the post of Warden of His Majesty's Mint. Newton was preceded to the city by a genius of another kind, the budding criminal William Chaloner. Thanks to his preternatural skills as a counterfeiter, Chaloner was rapidly rising in London's highly competitive underworld, at a time when organized law enforcement was all but unknown and money in the modern sense wa

  12. Indoor Air Quality in the Baroque Hall of the National Library in Prague - Preliminary Results

    Czech Academy of Sciences Publication Activity Database

    López-Aparicio, S.; Stankiewicz, J.; Smolík, Jiří

    - : -, 2010, s. 125. ISBN N. [ Indoor Air Quality Meeting /9./. Chalon-sur-Saone (FR), 21.04.2010-23.04.2010] Grant ostatní: MF(CZ) CZ0046/2/0001 Institutional research plan: CEZ:AV0Z40720504 Keywords : library * air quality evaluation Subject RIV: CF - Physical ; Theoretical Chemistry

  13. Airborne Particles in the Baroque Hall of the National Library in Prague

    Czech Academy of Sciences Publication Activity Database

    Mašková, Ludmila; Džumbová, Lucie; Ondráček, Jakub; Smolík, Jiří; Grontoft, T.; López-Aparicio, S.; Stankiewicz, J.

    - : -, 2010, s. 133. ISBN N. [ Indoor Air Quality Meeting /9./. Chalon-sur-Saone (FR), 21.04.2010-23.04.2010] R&D Projects: GA MŠk OC09049 Grant ostatní: MF(CZ) CZ0046/2/0001 Institutional research plan: CEZ:AV0Z40720504 Keywords : indoor /outdoor aerosol * number size distribution Subject RIV: CF - Physical ; Theoretical Chemistry

  14. Characterization of Airborne Particles in the Baroque Hall of the National Library in Prague

    Czech Academy of Sciences Publication Activity Database

    Mašková, Ludmila; Smolík, Jiří; Džumbová, Lucie; Ondráček, Jakub; López-Aparicio, S.; Grontoft, T.; Stankiewicz, J.

    -, č. 7 (2010), s. 141-146. ISSN 1581-9280. [9th Indoor Air Quality Meeting. Chalon-sur-Saone, 21.04.2010-23.04.2010] R&D Projects: GA MŠk OC09049 Grant ostatní: MF NF(CZ) A/CZ0046/2/0001 Institutional research plan: CEZ:AV0Z40720504 Keywords : indoor /outdoor aerosol * mass size distribution * chemical composition Subject RIV: CF - Physical ; Theoretical Chemistry

  15. Characterization of Airborne Particles in the Baroque Hall of the National Library in Prague

    Czech Academy of Sciences Publication Activity Database

    Džumbová, Lucie; Mašková, Ludmila; Ondráček, Jakub; Smolík, Jiří; Grontoft, T.; López-Aparicio, S.; Stankiewicz, J.

    - : -, 2010, s. 55. ISBN N. [ Indoor Air Quality Meeting /9./. Chalon-sur-Saone (FR), 21.04.2010-23.04.2010] R&D Projects: GA MŠk OC09049 Grant ostatní: MF(CZ) CZ0046/2/0001 Institutional research plan: CEZ:AV0Z40720504 Keywords : indoor /outdoor aerosol * mass size distribution * chemical composition Subject RIV: CF - Physical ; Theoretical Chemistry

  16. Plant-derived health: the effects of turmeric and curcuminoids Efectos saludables de la cúrcuma y de los curcuminoides

    OpenAIRE

    S. Bengmark; M.ª D. Mesa; Gil, A.

    2009-01-01

    Plants contain numerous polyphenols, which have been shown to reduce inflammation and hereby to increase resistance to disease. Examples of such polyphenols are isothiocyanates in cabbage and broccoli, epigallocatechin in green tee, capsaicin in chili peppers, chalones, rutin and naringenin in apples, resveratrol in red wine and fresh peanuts and curcumin/curcuminoids in turmeric. Most diseases are maintained by a sustained discreet but obvious increased systemic inflammation. Many studies su...

  17. Flood Risk Vulnerability Assessment: What are the Main Factors? Hierarchization of The Main Factors at a Regional Scale

    Science.gov (United States)

    Jouannic, G.; Kolli, Z.; Legendre, T.; Marchetti, M.; Gastaud, P.; Gargani, J.; Lermet, R.; Augeard, C.; Felts, D.; Arki, F.

    2015-12-01

    Recent studies have shown that the national flood risk exposure is high in France, with one fourth of the total population and a third of jobs located in risk areas. In this context, a global vulnerability assessment methodology is currently being developed in France to bring adequate tools for local territories to manage flood risk. This study addresses the question of the quantification, the qualification and the choice of these vulnerability indicators for a given territory. This work aims to propose a classification of nearly 40 of these indicators in terms of their relative impacts on the risk level estimated on two territories: Chalon-sur-Saône (Saône river) Garonne estuary (Garonne and Dordogne rivers, and Atlantic ocean) Through these cases study, 3 different spatial scales have been compared: the Prés-Saint-Jean district inside Chalon (0.6 km²), the city of Ambès (28.8 km²) and Chalon with its suburbs (72.2 km²). A principal component analysis (PCA) was applied and indicated a threshold in terms of urban impacts between the different flood scenarios. On Chalon, the PCA discriminates 2 groups of flood and highlighted a threshold between T20 and T50. A partial least-square regression (PLS) was computed to make predictions on vulnerability indicators values modelled on new flood scenarios. Their results were is useful to identify the most relevant vulnerability indicators as a function of their flood exposure. These statistical analysis aims to highlight the relationship between a variable of exposure level (hydrologic impact: water levels and flow velocity) with spatialized vulnerability indicators in a 100 m grid (e.g., population, job, etc.). Finally, to get a hierarchy of variables depending on their impact on the risk level, an ANOVA was computed. The selection of variables was performed with a stepwise selection to assess contributions of each dependant variable on the F-statistic as they are added to or removed from the model.

  18. Pianeta Nutrizione kids: international pediatric conference on food, physical activity, growth and well-being

    OpenAIRE

    Agosti, Massimo; Agostoni, Carlo; Chalons, Serge; Chavatte-Palmer, Pascale; Villares, José Manuel Moreno; Nicklaus, Sophie; Pereira-da-Silva, Luís; Pietrobelli, Angelo; ,; Rolland-Cachera, Marie Françoise; Zuccotti, Gian Vincenzo; Cappa, Marco; Caruso-Nicoletti, Manuela; Inzaghi, Elena; Cianfarani, Stefano

    2016-01-01

    Table of contents A1 Preterm and low birth weight nutrition in the first month life: implications for the outcome Massimo Agosti A2 Behind human milk and breastfeeding: not only food, not only growth Carlo Agostoni A3 To prevent obesity: importance and issues of cultural adaptation from weaning to 3 years of age Serge Chalons A4 Diet before and during pregnancy and child health: lessons from animal models Pascale Chavatte-Palmer A5 Infant nutrition: an opportunity to optimize future health Jo...

  19. Isolation, characterization and measurement of 14C content of dissolved humic matter: application to the dating of underground waters

    International Nuclear Information System (INIS)

    The aim of this thesis is to examine the feasibility of underground water dating using the measurement of the 14C content of the dissolved organic compounds (fulvic and humic acids). Four sites were selected: the Albian sandy aquifer near Soulaines (Aube, France), the deep Rupelian sandstone aquifer near Mol (Belgium), the granitic fractured massif of Peny (Limousin, France) and the chalk aquifer in the Eastern part of the Paris basin at Chalon (France). Chapter 1 gives a bibliographic synthesis of water dating knowledge using total dissolved inorganic carbon and dissolved organic compounds. The different correction models for the different carbon sources are examined in this part. Chapter 2 concerns the analytic techniques: extraction of the organic matter from water, characterization and isotopic methods, comparison of two resin extraction methods (DEAE and XAD-8 resins). Results are analyzed in chapter 3 for the characterization of the origin and evolution of organic compounds and for the selection of the most suitable organic fraction for isotope dating. The Soulaines' aquifer allows to evaluate the 14C entry signal on the organic fraction, while the 3 other aquifers with complex rock-water interactions serve as experimental fields for this new tracer. (J.S.)

  20. Estrogen leads to reversible hair cycle retardation through inducing premature catagen and maintaining telogen.

    Directory of Open Access Journals (Sweden)

    Hui-min Hu

    Full Text Available Estrogen dysregulation causes hair disorder. Clinical observations have demonstrated that estrogen raises the telogen/anagen ratio and inhibits hair shaft elongation of female scalp hair follicles. In spite of these clinical insights, the properties of estrogen on hair follicles are poorly dissected. In the present study, we show that estrogen induced apoptosis of precortex cells and caused premature catagen by up-regulation of TGF β2. Immediately after the premature catagen, the expression of anagen chalone BMP4 increased. The up-regulation of BMP4 may further function to prevent anagen transition and maintain telogen. Interestingly, the hair follicle stem cell niche was not destructed during these drastic structural changes caused by estrogen. Additionally, dermal papilla cells, the estrogen target cells in hair follicles, kept their signature gene expressions as well as their hair inductive potential after estrogen treatment. Retention of the characteristics of both hair follicle stem cells and dermal papilla cells determined the reversibility of the hair cycle suppression. These results indicated that estrogen causes reversible hair cycle retardation by inducing premature catagen and maintaining telogen.

  1. Development and introduction of a modular training and qualification concept for maintenance personnel

    International Nuclear Information System (INIS)

    The presentation entitled ''Development and Introduction of a Modular Training and Qualification Concept for Maintenance Personnel'' presents the background, concept and training modules of a reactor services training concept that was jointly elaborated by a working group consisting of the ''Maintenance manager workshop'' working panel of the VGB, the Kraftwerksschule (KWS) PowerTech Training Center, and AREVA NP GmbH in Erlangen and Offenbach. This concept is part of AREVA's comprehensive training and qualification approach which comprises inter alia extensive introduction sessions for new employees, the corporation-wide highly appreciated AREVA University as well as specialized training facilities as for example the CETIC in Chalon-sur-Saone, France and the training center in Lynchburg, USA, or the worldwide largest integration center for digital I and C equipment for safety applications in nuclear power plants in Erlangen. AREVA NP's training concept for maintenance personnel addresses not only employees from AREVA NP working in nuclear maintenance but also personnel from nuclear power plants as well as independent experts, representatives from authorities and other interest groups. (orig.)

  2. Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration.

    Science.gov (United States)

    Plikus, Maksim V; Mayer, Julie Ann; de la Cruz, Damon; Baker, Ruth E; Maini, Philip K; Maxson, Robert; Chuong, Cheng-Ming

    2008-01-17

    In the age of stem cell engineering it is critical to understand how stem cell activity is regulated during regeneration. Hairs are mini-organs that undergo cyclic regeneration throughout adult life, and are an important model for organ regeneration. Hair stem cells located in the follicle bulge are regulated by the surrounding microenvironment, or niche. The activation of such stem cells is cyclic, involving periodic beta-catenin activity. In the adult mouse, regeneration occurs in waves in a follicle population, implying coordination among adjacent follicles and the extrafollicular environment. Here we show that unexpected periodic expression of bone morphogenetic protein 2 (Bmp2) and Bmp4 in the dermis regulates this process. This BMP cycle is out of phase with the WNT/beta-catenin cycle, thus dividing the conventional telogen into new functional phases: one refractory and the other competent for hair regeneration, characterized by high and low BMP signalling, respectively. Overexpression of noggin, a BMP antagonist, in mouse skin resulted in a markedly shortened refractory phase and faster propagation of the regenerative wave. Transplantation of skin from this mutant onto a wild-type host showed that follicles in donor and host can affect their cycling behaviours mutually, with the outcome depending on the equilibrium of BMP activity in the dermis. Administration of BMP4 protein caused the competent region to become refractory. These results show that BMPs may be the long-sought 'chalone' inhibitors of hair growth postulated by classical experiments. Taken together, results presented in this study provide an example of hierarchical regulation of local organ stem cell homeostasis by the inter-organ macroenvironment. The expression of Bmp2 in subcutaneous adipocytes indicates physiological integration between these two thermo-regulatory organs. Our findings have practical importance for studies using mouse skin as a model for carcinogenesis, intra-cutaneous drug

  3. Delayed postural control during self-generated perturbations in the frail older adults

    Directory of Open Access Journals (Sweden)

    Kubicki A

    2012-02-01

    Full Text Available Alexandre Kubicki1–3, François Bonnetblanc1,2, Geoffroy Petrement3, Yves Ballay1,2, France Mourey2,4¹UFR STAPS, Université de Bourgogne, Dijon, France; ²Motricité et Plasticité, Institut National de la Santé et de la Recherche Médicale (INSERM, Dijon, France; ³SARL Fovea Interactive, Campus Industriel – Espace Entreprises, Chalon sur Saône, France; 4UFR Médecine, Université de Bourgogne, Dijon, FrancePurpose: The aim of this study was to investigate the coordination between posture and movement in pathological aging (frailty in comparison with normal aging, with the hypothesis that in pathological aging, postural control evolves towards a more reactive mode for which the perturbation induced by the movement is not anticipated and leads to delayed and late postural adjustments.Methods: Elderly subjects performed rapid focal arm-raising movements towards a target, from an upright standing position in two stimuli conditions: simple reaction time and choice reaction time (CRT. Hand and center of pressure (CoP kinematics were compared between a control group and a frail group of the same age.Results: In frail individuals, the entire movement was impaired and slowed down. In addition, postural adjustments that classically precede and accompany the focal arm movement were delayed and reduced, especially in the CRT condition in which the motor prediction is more limited. Finally, a correlation between the time to CoP maximal velocity and the timed up-and-go score was observed.Conclusion: In these patients, it was concluded that the control of the CoP displacement evolved from a proactive mode in which the perturbation associated with the arm movement is anticipated toward a more reactive mode in which the perturbation is compensated by late and delayed adjustments.Keywords: frailty, anticipatory postural adjustments, backward disequilibrium

  4. Records of natural fire and climate history during the last three glacial-interglacial cycles around the South China Sea

    Institute of Scientific and Technical Information of China (English)

    LUO; Yunli

    2001-01-01

    assessing Quaternary and Tertiary environments:Achievements and limits, Palaeogeography, Palaeoclimatology, Palaeoecology, 2000, 164: 397-407.[13]Timothy, P. J., William, G. C., Fossil charcoal, its recognition and palaeoatmospheric significance, Palaeogeography, Pa laeoclimatology, Palaeoecology, 1991, 97: 39-50.[14]Harris, T. M., Forest fire in the Mesozoic, Journal of Ecology, 1958, 46: 447-453.[15]Harris, T. M., Burnt ferns from the English Wealden, Proc. Geol. Assoc. London, 1981, 92: 47-58.[16]Cope, M. J., Chaloner, W. G., Wildfire, an interaction of biological and physical processes, in Geological Factors and the Evolution of Plants (ed. Tiffney, B. H.), Hartford: Yale University Press, 1985, 225-277.[17]Cope, M. J., Chaloner, W. G., Fossil charcoal as evidence of past atmospheric composition, Nature, 1980, 283: 647-649.[18]Chaloner, W. G., Fossil charcoal as an indicator of palaeoatmosphere oxygen level, J. Geol. Soc. Lodon, 1989, 146: 171-174.[19]Clark, J. S., Particle motion and the theory of charcoal analysis: Source area, transport, deposition, and sampling, Quater nary Research, 1988, 30: 81-91.[20]MacDonal, G. M., Larsen, C. P. S., Moser, K. A., The reconstruction of boreal forest fire history from lake sediments: Acomparison of charcoal, pollen sedimentological, and geochemical indices, Quaternary Science Reviews, 1991, 10: 53-71.[21]Swain, A. M., A history of fire and vegetation in northeast Minnesota as recorded in lake sediments, Quaternary Research,973, 3: 383-395.[22]Patternson, W. A., Edwards, K. J., Maguire, D. J., Microscopic charcoal as a fossil indicaror of fire, Quaternary Science Reviews, 1987, 6: 3-23.[23]Sander, P. M., Gee, C. T., Fossil charcoal: Techniques and applications, Review of Palaeobotany and Palynology, 1990, 63:269-279.[24]Patterson, III, W. A., Edwards, K. J., Maquire, D. J., Microscopic charcoal as a fossil indicator of fire, Quaternary Science Review, 1987, 6: 3-23.[25

  5. Erection progress of OL3 and other EPR projects

    International Nuclear Information System (INIS)

    The progress being made on the construction of the world's first EPR at Olkiluoto in Finland is clear to see: after work had started in October 2006 on the first civil structures for the reactor building, 2007 witnessed the other buildings also gradually taking shape. A key milestone was reached on June 7 when the first ring of the containment liner weighing no less than 218 tons was rigged into the reactor building. This had been preceded by completion of the turbine foundations inside the turbine building on April 28 following a concreting operation that had lasted 40 hours, allowing installation of the turbine condensers to then proceed. The very first component to be brought into the reactor building - a drain tank - was installed in mid-September. Fabrication of the major components is also well underway: the reactor pressure vessel at MHI in Japan, for example, will be completely finished as soon as it has passed its final pressure test in February 2008. And at AREVA's factory in Chalon, France, the first of the steam generators was recently fitted with all 6000 of its tubes having a total length of 140 km. Manufacturing of the other components is for the most part on schedule. Erection of the piping in the lower levels of the reactor building and the surrounding safeguard buildings should be starting in the spring of 2008. The number of employees on site will then rise to well over 2000. Handover of the 1st EPR will be from today's point of view mid 2011. Also in Flamanville in France where AREVA NP were charged by EOF with the turnkey delivery of the nuclear steam supply system the progress of preparation work is visible; in December 2007 there is the 1st concrete pouring, handover is planned for May 2012. In China AREVA NP will build 2 EPR Nl at the site of Taishan. Start of erection is scheduled September 2009 and the Chinese partners will be strongly involved in engineering, procurement and erection activities.

  6. Erection progress of OL3 and other EPR projects

    Energy Technology Data Exchange (ETDEWEB)

    Storr, Wolfgang [AREVA NP GmbH, Erlangen (Germany)

    2008-07-01

    The progress being made on the construction of the world's first EPR at Olkiluoto in Finland is clear to see: after work had started in October 2006 on the first civil structures for the reactor building, 2007 witnessed the other buildings also gradually taking shape. A key milestone was reached on June 7 when the first ring of the containment liner weighing no less than 218 tons was rigged into the reactor building. This had been preceded by completion of the turbine foundations inside the turbine building on April 28 following a concreting operation that had lasted 40 hours, allowing installation of the turbine condensers to then proceed. The very first component to be brought into the reactor building - a drain tank - was installed in mid-September. Fabrication of the major components is also well underway: the reactor pressure vessel at MHI in Japan, for example, will be completely finished as soon as it has passed its final pressure test in February 2008. And at AREVA's factory in Chalon, France, the first of the steam generators was recently fitted with all 6000 of its tubes having a total length of 140 km. Manufacturing of the other components is for the most part on schedule. Erection of the piping in the lower levels of the reactor building and the surrounding safeguard buildings should be starting in the spring of 2008. The number of employees on site will then rise to well over 2000. Handover of the 1st EPR will be from today's point of view mid 2011. Also in Flamanville in France where AREVA NP were charged by EOF with the turnkey delivery of the nuclear steam supply system the progress of preparation work is visible; in December 2007 there is the 1st concrete pouring, handover is planned for May 2012. In China AREVA NP will build 2 EPR Nl at the site of Taishan. Start of erection is scheduled September 2009 and the Chinese partners will be strongly involved in engineering, procurement and erection activities.

  7. Plant-derived health: the effects of turmeric and curcuminoids Efectos saludables de la cúrcuma y de los curcuminoides

    Directory of Open Access Journals (Sweden)

    S. Bengmark

    2009-06-01

    Full Text Available Plants contain numerous polyphenols, which have been shown to reduce inflammation and hereby to increase resistance to disease. Examples of such polyphenols are isothiocyanates in cabbage and broccoli, epigallocatechin in green tee, capsaicin in chili peppers, chalones, rutin and naringenin in apples, resveratrol in red wine and fresh peanuts and curcumin/curcuminoids in turmeric. Most diseases are maintained by a sustained discreet but obvious increased systemic inflammation. Many studies suggest that the effect of treatment can be improved by a combination of restriction in intake of proinflammatory molecules such as advanced glycation end products (AGE, advanced lipoperoxidation end products (ALE, and rich supply of antiinflammatory molecules such as plant polyphenols. To the polyphenols with a bulk of experimental documentation belong the curcuminoid family and especially its main ingredient, curcumin. This review summarizes the present knowledge about these turmericderived ingredients, which have proven to be strong antioxidants and inhibitors of cyclooxigenase-2 (COX-2, lipoxygenase (LOX and nuclear factor κ B (NF-κB but also AGE. A plethora of clinical effects are reported in various experimental diseases, but clinical studies in humans are few. It is suggested that supply of polyphenols and particularly curcuminoids might be value as complement to pharmaceutical treatment, but also prebiotic treatment, in conditions proven to be rather therapy-resistant such as Crohn's, long-stayed patients in intensive care units, but also in conditions such as cancer, liver cirrhosis, chronic renal disease, chronic obstructive lung disease, diabetes and Alzheimer's disease.Las plantas contienen un gran número de sustancias de naturaleza polifenólica con capacidad para reducir los procesos inflamatorios y, por lo tanto, incrementar la resistencia a determinadas enfermedades. Ejemplos de algunos polifenoles son los isotiocianatos presentes en la col

  8. Co-suppression in transgenic Petunia hybrida expressing chalcone synthase A (chsA)

    Institute of Scientific and Technical Information of China (English)

    LI; Yan; (

    2001-01-01

    [1]Napoli, C., Lemieux, C., Jorgensen, R., Introduction of a chimeric chalone synthase gene into petunia results in reversible cosuppession of homologous genes in trans, The Plant Cell, 1990, 2: 279-289.[2]Van der Krol, A.R., Mur, L.A., Beld, M. M. et al., Flavonnoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression, The Plant Cell, 1990, 2: 291-299.[3]Manika, P.B., Bhadra, U., Birchler, J., Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase by White-Adh transgene is Polycomb dependent, Cell, 1997, 90: 479-498.[4]de Carvalho Niebel, F., Frendo, P., Van Montagu, M. et al., Post-transcriptional cosuppression of ?-1,3-glucanase transgene expression in homozygous plants, EMBO J., 1992, 11: 2595-2602.[5]Van Blokland, R., Van der Geest, N., Mol, J. N. M. et al., Transgene-mediated suppression of chalcone synthase expression in Petunia hybrida results from an increase in RNA turnover, The Plant Cell, 1994, 6: 861-877.[6]Stam, M., Mol, J. N. M., Kooter, J. M., The silence of genes in transgenic plants, Annals of Bot., 1997, 79: 3-12.[7]Vaucheret, H., Beclin, C., Elmayan, T. et al., Transgene-induced gene silencing in plants, Plant J., 1998, 16(6): 651-659.[8]Shao, L., Li, Y., Yang, M. Z. et al., Transformation of Petunia hybrida with chalcone synthase A (chsA) resulting flower colour alteration and male sterility, Acta Botanica Sinica (in Chinese), 1996, 38(7): 517-524.[9]Koes, R. E., Spelt, C. E., Mol, J. N. M., The chalcone synthase multigene family of Petunia hybrida (V30): differential, light-regulated expression during flower development and UV light induction, Plant Mol. Biol., 1989, 12: 213-225.[10]Drews, G. N., Beals, T. P., Bul, A. Q. et al., Regional and cell-specific expression patterns during petal development, The Plant Cell, 1992, 4: 1383-1404.[11]Martin, C., Gerats, T., Control of pigment biosynthesis genes during petal development, The

  9. Steam generator tube laser sleeving

    International Nuclear Information System (INIS)

    For many years, Framatome has been used with different techniques and means to perform the steam generator tube sleeving operation, such as the 'mechanical' either GTAW welded or kinetic welding process. As soon as first power laser units appeared on the market we felt right interested in applying this process to the sleeving operation. After comparison between all the processes and equipments existing at that time (that is to say CO2 and YAG laser units), we chose the YAG and bought a 1.2 kW NEC laser unit in 1988. As it was installed in our Welding Center of Le Creusot, this equipment enabled us carrying out a preliminary test programme which targets were: getting the mastery of the equipment and associated technologies, implementing this process for the sleeve welding operation by improvement of the welding-pen. The NEC laser unit became afterwards transferred to our workshop in Chalon-sur-Saone (June 1990), where we achieved the final tests of the process at the same time we were investigating the development of industrial operation means. The actual program is mainly focused on 7/8'' tube steam generator repair process at tubesheet outlet. Yet made sure that our methods and means apply as well to 3/4'' tubes up to second tube support-plate level. Sleeves are made of heat-treated Inconel 690. The sleeved unit has been designed to provide the same breaking strength and leak-tightness as the tube. The upper part of sleeve consists of an anti-pop out length which ensures some locking-up in case the tube breaks in upper transition expansion area. Preliminary tests dealt with the various parameters which may exert an influence on geometry and quality of the, weld bead, as: - laser beam power (for continuous and pulsed modes), - welding speed, - focal spot size and location from the surface to be welded, - protective gas. After performance of preliminary tests on many thousands of weld beads we decided to use the process according to following criteria: Weld quality