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Sample records for challenging tumor entity

  1. Emerging tumor entities and variants of CNS neoplasms.

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    Cenacchi, Giovanna; Giangaspero, Felice

    2004-03-01

    Since the appearance in 2000 of the World Health Organization (WHO) classification for central nervous system (CNS) neoplasms, numerous descriptions of new entities or variants have appeared in the literature. In the group of neuronal and mixed glioneuronal neoplasms are lesions with distinctive morphological features that are still not included in a precise classification, including extraventricular neurocytoma, papillary glioneuronal tumor, rosette-forming glioneuronal of the fourth ventricle, glioneuronal with neuropil-like rosette, and DNT-like tumor of the septum pellucidum. The glioneuronal tumor with neuropil-like rosette and oligodendroglioma with neurocytic differentiation represent morphological variants of genetically proven diffuse gliomas. The lipoastrocytoma and the pilomixoid astrocytoma enlarge the group of astrocytic lesions. Rare, low-grade gliomas of the spinal cord with extensive leptomeningeal dissemination associated with unusual neuroimaging are described. The chordoid glioma of the third ventricle and the papillary tumor of the pineal region seem to be correlated by a common histogenesis from the specialized ependyma of the subcommissural organ. An embryonal tumor with neuropil and true rosettes combining features of neuroblastoma and ependymoblastoma is discussed. These new, recently described lesions indicate that the complex morphologic spectrum of CNS tumors is far from being completely delineated.

  2. Keratocystic odontogenic tumor involving the maxillary sinus: A rare entity

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    Mohammad Asif Kiresur

    2016-01-01

    Full Text Available The keratocystic odontogenic tumor (KCOT is a frequently encountered developmental cyst of the jaws. The occurrence of KCOT in the maxillary sinus is rare. The mucosa of the maxillary sinus is susceptible to infections, allergic diseases, and neoplasm. The anatomic position of maxillary premolar and molar teeth is in close contact with the sinus predispose to spreading of pulp and periodontal infection, odontogenic cyst, and tumors to the sinus. Diagnosis and treating KCOT in maxillary sinus is challenging as treatment has to be rendered for sinusitis because of pathology in the sinus and for KCOT. We report a case of 35-year-old female with KCOT involving the lining of the maxillary sinus and put forward hypotheses for the origin of KCOT in the maxillary sinus.

  3. Paraganglioma: a potentially challenging tumor.

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    Trombetta, Mark; Silverman, Jan; Colonias, Athanasios; Lee, Vincent; Mohanty, Alok; Parda, David

    2008-03-01

    Paragangliomas are usually low-grade neoplasms with a benign natural history. While the treatment of paraganglioma has historically been controversial, surgery and radiotherapy have become standardized as therapies of choice for primary therapy. More recently, stereotactic radiosurgery has been used effectively against this rare tumor. The development of metastatic disease in patients with paraganglioma is an unusual and challenging event. This case report and review describes the specific features of this disease and the multiple therapeutic options.

  4. Sinonasal Phosphaturic Mesenchymal Tumor: A Rare and Misinterpreted Entity

    OpenAIRE

    Arnaoutakis, Demetri; Naseri, Iman

    2015-01-01

    Objectives Oncogenic osteomalacia is a paraneoplastic syndrome in which the tumor secretes a peptide-like hormone, fibroblast growth factor, resulting in urinary loss of phosphates. Methods We present the case of a 50-year-old woman with a benign phosphaturic mesenchymal tumor (PMT) involving the ethmoid sinus with obstruction of the ostiomeatal complex causing unilateral nasal airway obstruction. Results The tumor was initially thought to be an esthesioneuroblastoma based on primary patholog...

  5. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

    Science.gov (United States)

    Sturm, Dominik; Orr, Brent A; Toprak, Umut H; Hovestadt, Volker; Jones, David T W; Capper, David; Sill, Martin; Buchhalter, Ivo; Northcott, Paul A; Leis, Irina; Ryzhova, Marina; Koelsche, Christian; Pfaff, Elke; Allen, Sariah J; Balasubramanian, Gnanaprakash; Worst, Barbara C; Pajtler, Kristian W; Brabetz, Sebastian; Johann, Pascal D; Sahm, Felix; Reimand, Jüri; Mackay, Alan; Carvalho, Diana M; Remke, Marc; Phillips, Joanna J; Perry, Arie; Cowdrey, Cynthia; Drissi, Rachid; Fouladi, Maryam; Giangaspero, Felice; Łastowska, Maria; Grajkowska, Wiesława; Scheurlen, Wolfram; Pietsch, Torsten; Hagel, Christian; Gojo, Johannes; Lötsch, Daniela; Berger, Walter; Slavc, Irene; Haberler, Christine; Jouvet, Anne; Holm, Stefan; Hofer, Silvia; Prinz, Marco; Keohane, Catherine; Fried, Iris; Mawrin, Christian; Scheie, David; Mobley, Bret C; Schniederjan, Matthew J; Santi, Mariarita; Buccoliero, Anna M; Dahiya, Sonika; Kramm, Christof M; von Bueren, André O; von Hoff, Katja; Rutkowski, Stefan; Herold-Mende, Christel; Frühwald, Michael C; Milde, Till; Hasselblatt, Martin; Wesseling, Pieter; Rößler, Jochen; Schüller, Ulrich; Ebinger, Martin; Schittenhelm, Jens; Frank, Stephan; Grobholz, Rainer; Vajtai, Istvan; Hans, Volkmar; Schneppenheim, Reinhard; Zitterbart, Karel; Collins, V Peter; Aronica, Eleonora; Varlet, Pascale; Puget, Stephanie; Dufour, Christelle; Grill, Jacques; Figarella-Branger, Dominique; Wolter, Marietta; Schuhmann, Martin U; Shalaby, Tarek; Grotzer, Michael; van Meter, Timothy; Monoranu, Camelia-Maria; Felsberg, Jörg; Reifenberger, Guido; Snuderl, Matija; Forrester, Lynn Ann; Koster, Jan; Versteeg, Rogier; Volckmann, Richard; van Sluis, Peter; Wolf, Stephan; Mikkelsen, Tom; Gajjar, Amar; Aldape, Kenneth; Moore, Andrew S; Taylor, Michael D; Jones, Chris; Jabado, Nada; Karajannis, Matthias A; Eils, Roland; Schlesner, Matthias; Lichter, Peter; von Deimling, Andreas; Pfister, Stefan M; Ellison, David W; Korshunov, Andrey; Kool, Marcel

    2016-02-25

    Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated "CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2)," "CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC)," "CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1)," and "CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)," will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.

  6. Congenital Granular Cell Tumor – A Rare Entity

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    Monal Yuwanati

    2015-03-01

    Full Text Available Congenital granular cell tumor is a rare benign neoplastic growth affecting the gingival mucosa of neonates. Prenatal ultrasound diagnosis has recently come to focus and in spite of several reports on immune-histochemical and other advanced marker studies, the cause and origin of the lesion remains debatable till date. Review of literature on prenatal diagnosis and histopathology along with immunohistochemistry is discussed.

  7. Mammary Analogue Secretory Carcinoma (MASC) of the salivary gland: A new tumor entity.

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    Damjanov, Ivan; Skenderi, Faruk; Vranic, Semir

    2016-08-01

    Mammary analogue secretory carcinoma (MASC) is a recently described low-grade malignant tumor of the salivary glands, biologically and morphologically equivalent to secretory breast carcinoma. We give a brief overview of this new entity, including morphological, immunohistochemical, molecular-genetic, clinical, epidemiologic features, differential diagnosis, and outcome results. PMID:27483184

  8. Calcifying epithelial odontogenic tumor (Pindborg tumor without calcification: A rare entity

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    Seema Kaushal

    2012-01-01

    Full Text Available The calcifying epithelial odontogenic tumor is a rare benign odontogenic tumor that was first described by Pindborg in 1955. It accounts for less than 1% of all odontogenic neoplasms. The tumor is characterized histologically by the presence of polygonal epithelial cells, calcification, and eosinophilic deposits resembling amyloid. Noncalcifying Pindborg tumor is very rare and only three cases have been documented in the English language literature so far. We present an additional case of noncalcifying Pindborg tumor and review the previously reported cases. Because noncalcifying Pindborg tumor is believed to be an aggressive variant, a definitive resection of the tumor with tumor-free surgical margins and long-term follow-up is recommended.

  9. Calcifying epithelial odontogenic tumor (Pindborg tumor) without calcification: A rare entity.

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    Kaushal, Seema; Mathur, Sandeep R; Vijay, Maneesh; Rustagi, Ankur

    2012-01-01

    The calcifying epithelial odontogenic tumor is a rare benign odontogenic tumor that was first described by Pindborg in 1955. It accounts for less than 1% of all odontogenic neoplasms. The tumor is characterized histologically by the presence of polygonal epithelial cells, calcification, and eosinophilic deposits resembling amyloid. Noncalcifying Pindborg tumor is very rare and only three cases have been documented in the English language literature so far. We present an additional case of noncalcifying Pindborg tumor and review the previously reported cases. Because noncalcifying Pindborg tumor is believed to be an aggressive variant, a definitive resection of the tumor with tumor-free surgical margins and long-term follow-up is recommended.

  10. Papillary glioneuronal tumor: a new entity awaiting inclusion in WHO classification

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    Bhatia Alka; Kumar Yashwant; Radotra BD; Mohindra Sandeep

    2007-01-01

    Abstract Papillary glioneuronal tumor (PGNT) is a recently described lesion of the brain, which is still not included as a separate entity in WHO classification. To date 32 cases of PGNT have been reported in the world literature. We report the 33rd case, a 41-year-old male who presented with pain in the nape of the neck. MRI showed a large, predominantly solid mass involving the cerebral parenchyma of the left temporal and parieto-occipital lobes with extension across the midline. Histologic...

  11. Sarcoma-like mural nodule in a borderline mucinous tumor of the ovary: A rare entity.

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    Ghosh, Prithwijit; Saha, Kaushik; Bhowmik, Sourav

    2014-10-01

    Sarcoma-like mural nodule (SLMN) is a very uncommon and misleading benign entity which may be associated with benign, borderline or malignant mucinous neoplasm of the ovary. It should be distinguished from other malignant mural nodules with sarcoma, carcinosarcoma or anaplastic carcinoma for proper management. We report a rare case of SLMN in a borderline mucinous tumor of the ovary in a 30-year-old lady. In spite of having confusing histopathological features the final diagnosis was made depending on the younger age of the patient, well circumscription of the nodule, absence of vascular invasion and immunohistochemical profile.

  12. Papillary glioneuronal tumor: a new entity awaiting inclusion in WHO classification

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    Bhatia Alka

    2007-02-01

    Full Text Available Abstract Papillary glioneuronal tumor (PGNT is a recently described lesion of the brain, which is still not included as a separate entity in WHO classification. To date 32 cases of PGNT have been reported in the world literature. We report the 33rd case, a 41-year-old male who presented with pain in the nape of the neck. MRI showed a large, predominantly solid mass involving the cerebral parenchyma of the left temporal and parieto-occipital lobes with extension across the midline. Histologically, it was a mixture of glial and neuronal components. Architecturally, the tumor was notable for its pseudopapillary pattern with hyalinized vessels. PGNT is considered as a low grade neoplasm and surgical excision has been curative in most of the cases. More cases of PGNT need to be reported as they may add further knowledge about its biologic behavior and allow its recognition and classification.

  13. GASTROINTESTINAL STROMAL TUMORS OF THE ANORECTUM--A SPECIAL ENTITY: GISTs OF THE ANORECTUM

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Objective: Until recently gastrointestinal stromal tumor (GIST) has been separated from other mesenchymal neoplasms and categorized as a special entity. Morphology of tumor cells and immunohistochemical findings with CD117 are crucial in the pathological diagnosis of GISTs. Newly developed drug imatinib mesylate (formerly called STI571) has been proved effective for GISTs. The distinction of GISTs and other mesenchymal tumors has great clinical significance, especially for lesions located in the anorectum. Methods: The authors searched the database of Peking University, School of Oncology for patients with anorectal neoplasms treated from January 1995 to June 2002. Information of 12 patients with anorectal mesenchymal tumors was collected. The patients were reevaluated and discussed according to current criteria of GISTs with clinical data and immunohistochemical findings. Results: Six patients (including 3 males) were finally diagnosed as anorectal GISTs. The median age of those patients was 59.5 years (27(69). The symptoms were not specific. Three cases with original diagnosis of leiomyoma or leiomyosarcoma were actually GISTs. A total of six anorectal GISTs was found comprising about 1.06% of patients with anorectal neoplasmas in the same period. Besides CD117, CD34 and vimentin were also expressed in majority of these patients. Five of the six patients underwent surgical resection one of which received neoadjuvant chemotherapy before resection. Conclusion: Anorectal GISTs should be considered as a special entity using current diagnostic criteria. Surgical resection remains the primary therapeutic strategy. Neoadjuvant imatinib mesylate may be helpful in sphincter-sparing operations and improvement of the quality of life for these patients.

  14. Well-differentiated neuroendocrine tumor of tailgut cyst. A rare entity with controversial medical opportunities.

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    Damato, Angela; Pusceddu, Sara; Milione, Massimo; Mazzaferro, Vincenzo; Magli, Michelle; Seregni, Ettore; De Braud, Filippo; Buzzoni, Roberto

    2013-01-01

    The incidence of neuroendocrine tumors is rising, and this rise is explained by more than just better diagnostic procedures. About 85% of these neoplasms arise in gastrointestinal or pulmonary sites, but cases where the location is more unusual also occur in clinical practice. The tailgut cyst is a rare entity well described in the medical literature, but a neuroendocrine tumor within such a cyst is a very rare event, with about 30 cases described in the literature to date. In this report we present the case of a young woman with this unusual diagnosis. The characteristics of the case differ from most previous case reports in a few respects: the patient was a young rather than middle-aged female; she had a presacral mass with a significant solid component; at diagnosis, there was evidence of a lytic lesion in the coccyx. Despite this particular medical presentation, radical surgery was accomplished. In this disease the greatest risk is local relapse, but adjuvant radiotherapy may compromise the patient's fertility. We therefore opted for strict control only, but this decision might be debatable. PMID:24326850

  15. Collecting duct carcinomas represent a unique tumor entity based on genetic alterations.

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    Frank Becker

    Full Text Available Collecting duct carcinoma (CDC is a rare renal neoplasm that is associated with poor prognosis due to its highly aggressive course and limited response to immuno- or chemotherapy. Histologically, CDC is defined as a subtype of renal cell carcinomas, but in some cases, it is difficult to differentiate from urothelial carcinomas (UC. Therefore the aim of this study was to determine genetic alterations of CDC in comparison to that of urothelial carcinomas of the upper urinary tract (UUT-UC to clarify the histological origin of this rare tumor entity. Twenty-nine CDC samples were obtained from seven different German centers and compared with twenty-six urothelial carcinomas of the upper urinary tract. Comparative genomic hybridization (CGH was used to investigate the genetic composition of patients' tumors and allowed the detection of losses and gains of DNA copy numbers throughout the entire genome. The clinical data were correlated with CGH results. CGH analysis of CDC revealed DNA aberrations in many chromosomes. DNA losses were more frequently observed than gains, while high-level amplifications were not detected. The mean frequency of CDC chromosomal aberrations (4.9/case was slightly lower than that in UUT-UC (5.4/case. Recurrent CDC DNA losses occurred at 8p (n=9/29, 16p (9/29, 1p (n=7/29 and 9p (n=7/29, and gains occurred in 13q (n=9/29. In contrast to CDC, the most frequently detected UUT-UC DNA aberration was a loss at 9q (n=13/26. DNA losses at 9q, 13q and 8q as well as gains at 8p showed significant variations in UUT-UC compared to CDC. There was no correlation between the patients' clinical course and the presence or absence of these recurrent genetic alterations. CDCs are characterized by a different genetic pattern compared to UUT-UC. Regarding the published data on renal cell carcinoma, we conclude that CDC appears to be a unique entity among kidney carcinomas.

  16. Gastrointestinal Stromal Tumors: Diagnostic and Therapeutic Challenges

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    Ibrahim Abdelkader Salama

    2014-09-01

    Full Text Available Background: Gastrointestinal stromal tumors (GIST are the most common mesenchymal neoplasms of the digestive system. They originate from the interstitial cells of Cajal and are characterized by the over expression of KIT protein (Tyrosine Kinase, and they pose a diagnostic and therapeutic dilemma. Objective: A challenge in diagnosis and treatment of GIST Patients & Methods: This is a retrospective study of GIST cases that diagnosed and treated in our center during the past 5 years. These studies include clinical characteristics, imaging techniques, neoadjuvant therapy, surgical techniques, immunohistochemistry, and prognosis of such cases. Results: Sixteen patients were diagnosed as having GIST (12 males/4 females with a mean age 62 years (31-83 years. Diagnosis was made preoperatively in 11 patients (69% and intraoperatively with histopatholgical confirmation in five patients (31%. The site of the tumor was detected in the stomach in 6 cases (37.5%, one in duodenum (6.25%, five in small intestine (31.25%, one in mesentery (6.25%, two in colon (12.5% and one rectal GIST (6.25%. The main presentation of the disease was anemia, GIT bleeding and abdominal mass. Fourteen patients considered resectable and they were operated upon (87.5% and in two patients (12.5% neadjuvant therapy was started with favorable response in one case and poor response in other one with advanced GIST. All patients received Imatinib as adjuvant therapy. Mean follow up period was 33 months (4-54 months. Conclusion: GIST is a complex and challenging disease that requires a multidisciplinary approach in specililized center for better prognosis of such disease.

  17. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

    NARCIS (Netherlands)

    D. Sturm; B.A. Orr; U.H. Toprak; V. Hovestadt; D.T.W. Jones; D. Capper; M. Sill; I. Buchhalter; P.A. Northcott; I. Leis; M. Ryzhova; C. Koelsche; E. Pfaff; S.J. Allen; G. Balasubramanian; B.C. Worst; K.W. Pajtler; S. Brabetz; P.D. Johann; F. Sahm; J. Reimand; A. Mackay; D.M. Carvalho; M. Remke; J.J. Phillips; A. Perry; C. Cowdrey; R. Drissi; M. Fouladi; F. Giangaspero; M. Łastowska; W. Grajkowska; W. Scheurlen; T. Pietsch; C. Hagel; J. Gojo; D. Lötsch; W. Berger; I. Slavc; C. Haberler; A. Jouvet; S. Holm; S. Hofer; M. Prinz; C. Keohane; I. Fried; C. Mawrin; D. Scheie; B.C. Mobley; M.J. Schniederjan; M. Santi; A.M. Buccoliero; S. Dahiya; C.M. Kramm; A.O. von Bueren; K. von Hoff; S. Rutkowski; C. Herold-Mende; M.C. Frühwald; T. Milde; M. Hasselblatt; P. Wesseling; J. Rößler; U. Schüller; M. Ebinger; J. Schittenhelm; S. Frank; R. Grobholz; I. Vajtai; V. Hans; R. Schneppenheim; K. Zitterbart; V.P. Collins; E. Aronica; P. Varlet; S. Puget; C. Dufour; J. Grill; D. Figarella-Branger; M. Wolter; M.U. Schuhmann; T. Shalaby; M. Grotzer; T. van Meter; C.M. Monoranu; J. Felsberg; G. Reifenberger; M. Snuderl; L.A. Forrester; J. Koster; R. Versteeg; R. Volckmann; P. van Sluis; S. Wolf; T. Mikkelsen; A. Gajjar; K. Aldape; A.S. Moore; M.D. Taylor; C. Jones; N. Jabado; M.A. Karajannis; R. Eils; M. Schlesner; P. Lichter; A. von Deimling; S.M. Pfister; D.W. Ellison; A. Korshunov; M. Kool

    2016-01-01

    Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagno

  18. Solid Tumors: Facts, Challenges and Solutions

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    Gavhane Y. N.

    2011-01-01

    Full Text Available In 2005, 7.6 million people died of cancer out of 58 million deaths worldwide. Based on projections, cancer deaths will continue to rise with an estimated 9 million people dying from cancer in 2015, and 11.4 million dying in 2030. The increasing trend of cancer incidence has forced the humanity to work more on the cancer prevention and treatments. It is important for the public health professionals to understand the dynamics and kinetics of tumor incidence for future strategies. Over here we have reviewed solid tumor modeling, their detail classification, treatment strategies available along with their merits and demerits. To overcome these limitations, design focus for future studies is suggested.

  19. Foreign body granuloma mimicking recurrent intracranial tumor: a very rare clinical entity.

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    Askin Esen Hasturk

    2013-11-01

    Full Text Available Gelatin sponge, oxidized cellulose and microfibrillar collagen are used to achieve hemostasis during neurosurgical procedures. Hemostatic agents may produce clinically symptomatic, radiologically apparent mass lesions. The differential diagnosis should include the foreign body along with recurrent tumor. We present a case of intracranial hemostatic agents found in a 56-year-old male patient seven years after undergoing a craniotomy for a left posterior parietal convexity meningioma. Preoperative magnetic resonance imaging (MRI suggested the presence of a recurrent tumor. We emphasize that although it is rare, a granuloma due to a foreign body reaction can result in a false image of tumor recurrence.

  20. DEFINITION OF A NEW ENTITY OF MALIGNANT EXTRAGONADAL GERM-CELL TUMORS

    NARCIS (Netherlands)

    VANECHTEN, J; DEJONG, B; SINKE, RJ; WEGHUIS, DO; SLEIJFER, DT; OOSTERHUIS, JW

    1995-01-01

    Two malignant extragonadal germ cell tumors are reponed, histologically classified as immature teratomas, having pseudodiploid karyotypes with complex structural rearrangements but lacking isochromosome 12p or other rearrangements involving 12p. The absence of 12p material in structural rearrangemen

  1. Solid Tumors: Facts, Challenges and Solutions

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    Gavhane Y. N.; Shete A. S; Bhagat A. K.,; Shinde V. R.,; Bhong K. K.; Khairnar G. A.,; Yadav A. V.

    2011-01-01

    In 2005, 7.6 million people died of cancer out of 58 million deaths worldwide. Based on projections, cancer deaths will continue to rise with an estimated 9 million people dying from cancer in 2015, and 11.4 million dying in 2030. The increasing trend of cancer incidence has forced the humanity to work more on the cancer prevention and treatments. It is important for the public health professionals to understand the dynamics and kinetics of tumor incidence for future strategies. Over here we ...

  2. Primary Cervical Placental Site Trophoblastic Tumor: A Rare Entity with an Unusual Presentation

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    Kanthilatha Pai

    2013-10-01

    Full Text Available Placental site trophoblastic tumour (PSTT is the least common form of gestational trophoblastic neoplasia accounting for only 1-2% of trophoblastic tumors. Approximately 200 cases are reported in English literature. PSTT presenting as a cervical growth is even less common. Differentiation of PSTT from other types of GTN, non-neoplastic gestational trophoblastic disease and non-trophoblastic tumors is important clinically due to differences in their therapeutic approaches.Appreciation of the morphologic features and immunophenotype allows their accurate diagnosis.Although most of the cases of PSTT behave in a benign fashion,the clinical behavior of PSTT can sometimes be variable and several prognostic factors can help to predict the biological behavior of this condition. We report a rare case of placental site trophoblastic tumor, presenting as a cervical mass, in a 38 year old female, and review the literature. [J Interdiscipl Histopathol 2013; 1(5.000: 286-289

  3. Calcitonin-negative neuroendocrine tumor of thyroid gland mimicking anaplastic carcinoma: an unusual entity

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    Arpaci, Rabia Bozdogan; Berkesoglu, Mustafa; Dag, Ahmet; Sezer, Emel; Bal, Kemal Koray; Vayısoğlu, Yusuf

    2015-01-01

    Medullary thyroid cancer is the neuroendocrine tumor (NET) of thyroid with mostly both secreting calcitonin and immunohistochemically showing calcitonin positivity. Occasionally; NETs of thyroid may have little or no calcitonin expression. We present a case of serum calcitonin negative and immunohistochemically calcitonin-negative staining tumor with positive reaction to neuroendocrine markers synaptophysin and chromogranin-A. The patient’s right vocal cord was paralytic and thyroid mass was huge with descending to thorax till hilar region. We discussed diagnostic difficulties and way of treatment about NETs of thyroid with the light of current literature with this case. PMID:26312221

  4. Adenomatoid odontogenic tumor in the maxillary antrum: A rare case entity

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    Kavitha Krishnamurthy

    2014-01-01

    Full Text Available Adenomatoid odontogenic tumor (AOT is an uncommon benign tumor of odontogenic origin. It occurs in the second decade of life. Females are more commonly affected than males. AOT has a striking tendency to occur in the anterior maxilla; however, very few cases have been reported to occur in the maxillary antrum. This is a case report of a 17-year-old male presented with a large radiolucent lesion associated with the crown of an unerupted canine located in the right maxillary antrum, which was clinically diagnosed as dentigerous cyst. The histopathological examination revealed the presence of AOT.

  5. Advanced small-cell ovarian carcinoma, hypercalcemic type: a challenging therapeutic entity

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    Rafael Caparica Bitton

    2014-09-01

    Full Text Available Small-cell ovarian carcinoma (SCOC is a rare and aggressive neoplasia, predominantly affecting young women who are frequently first diagnosed with advanced stage disease. Platinum-based chemotherapy (ChT can provide high response rates and rapidly ameliorate symptoms in this scenario. However, progression after chemotherapy usually occurs quickly, leading to high mortality rates. In addition, ChT complications, such as tumor lysis syndrome (TLS can also occur, jeopardizing the patient’s outcome. We present a case of metastatic SCOC in a 47-year-old patient who achieved tumor response after platinum-based chemotherapy and developed TLS, from which she recovered with supportive treatment. After the second ChT cycle, she developed febrile neutropenia and died 8 weeks after the diagnosis of SCOC. Although SCOC is a chemo-sensitive tumor, short-lived responses and frequent chemotherapy complications lead to a dismal prognosis.

  6. Spindle Cell Variant of Embryonal Rhabdomyosarcoma: A Rare Entity with Diagnostic Challenges

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    Kaur, Anureet; Suri, Anil Kumar; Malik, Harsh

    2016-01-01

    The spindle cell variant of embryonal rhabdomyosarcoma is a rare and a better differentiated variant of embryonal rhabdomyosarcoma, having a better prognosis compared to other types of rhabdomyosarcomas. So, it needs to be distinguished from classical forms of the neoplasm. Its morphological resemblance to spindle cell neoplasms like leiomyosarcomas and fibrosarcomas may pose diagnostic difficulties for the pathologist. This problem can be overcome by careful search for rhabdomyoblasts in sections, which are usually few, and Immunohistochemistry for myogenin. In the present case, a 15-year-old female presented with a progressively increasing swelling in the right upper eyelid, which was diagnosed as a rare variant of rhabdomyosarcoma. We have also attempted to discuss its differential diagnosis, and to emphasize the fact that this rare entity may be misdiagnosed. PMID:27656457

  7. Buschke-Lowenstein tumor of the inguinal region: A rare entity in a rarer location

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    Priyanka Aggarwal

    2015-02-01

    Full Text Available Buschke–Lowenstein tumor (BLT, also known as giant condyloma accuminata, first described in 1896 by Buschke, is a rare, slow‑growing, locally invasive, mass lesion commonly affecting the anogenital region in immunocompromised males. This florid type of verrucous carcinoma is known for its high rate of recurrence as well as malignant conversion to squamous cell carcinoma. BLTs have been commonly reported to involve the penis, scrotum, bladder, vulva and perianal or anorectal regions. Our index case remains distinguished on the account of the rare anatomical location, causing a diagnostic dilemma, and once diagnosed managed adequately via surgery alone

  8. Hyalinizing trabecular tumor of the thyroid gland: A puzzling entity on fine needle aspiration cytology

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    Jitendra Nasit

    2014-01-01

    Full Text Available Hyalinizing trabecular tumor (HTT is a rare unique but controversial thyroid neoplasm, characterized by prominent trabecular growth pattern and stromal hyalinization. Whether HTT is a benign tumor or a variant of papillary thyroid carcinoma (PTC is still unclear. Cytology findings of HTT have been described in few reports. Cytological features of HTT frequently overlap with those of PTC and medullary thyroid carcinoma, which can lead to frequent misdiagnosis. In order to avoid overtreatment like total thyroidectomy, pathologist should be aware of cytological features of HTT. We present a case of 35-year-old female with a right-side thyroid swelling for three years. Fine needle aspiration cytology was performed. According to The Bethesda System for Reporting Thyroid Cytopathology, cytological diagnosis of benign thyroid neoplasm was made. Histopathology of the right thyroidectomy specimen showed HTT. Accurate preoperative diagnosis of HTT requires a very meticulous and cautious approach in the evaluation of cytological features. Trabecular pattern of cells, vague curved nuclear palisading, radiating arrangement of cells around hyaline material, spindled to elongated cells, filamentous cytoplasmic processes with ill-defined cell border and yellow bodies are important diagnostic features of HTT. Nuclear features alone are insufficient for the diagnosis of HTT. Any suspicious cytology of thyroid lesion should follow hemithyroidectomy and histopathological evaluation.

  9. Clinical tumor sequencing: opportunities and challenges for precision cancer medicine.

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    Damodaran, Senthilkumar; Berger, Michael F; Roychowdhury, Sameek

    2015-01-01

    Advances in tumor genome sequencing have enabled discovery of actionable alterations leading to novel therapies. Currently, there are approved targeted therapies across various tumors that can be matched to genomic alterations, such as point mutations, gene amplification, and translocations. Tools to detect these genomic alterations have emerged as a result of decreasing costs and improved throughput enabled by next-generation sequencing (NGS) technologies. NGS has been successfully utilized for developing biomarkers to assess susceptibility, diagnosis, prognosis, and treatment of cancers. However, clinical application presents some potential challenges in terms of tumor specimen acquisition, analysis, privacy, interpretation, and drug development in rare cancer subsets. Although whole-genome sequencing offers the most complete strategy for tumor analysis, its present utility in clinical care is limited. Consequently, targeted gene capture panels are more commonly employed by academic institutions and commercial vendors for clinical grade cancer genomic testing to assess molecular eligibility for matching therapies, whereas whole-exome and transcriptome (RNASeq) sequencing are being utilized for discovery research. This review discusses the strategies, clinical challenges, and opportunities associated with the application of cancer genomic testing for precision cancer medicine. PMID:25993170

  10. Opportunities and Challenges for Pancreatic Circulating Tumor Cells.

    Science.gov (United States)

    Nagrath, Sunitha; Jack, Rhonda M; Sahai, Vaibhav; Simeone, Diane M

    2016-09-01

    Sensitive and reproducible platforms have been developed for detection, isolation, and enrichment of circulating tumor cells (CTCs)-rare cells that enter the blood from solid tumors, including those of the breast, prostate gland, lung, pancreas, and colon. These might be used as biomarkers in diagnosis or determination of prognosis. CTCs are no longer simply detected and quantified; they are now used in ex vivo studies of anticancer agents and early detection. We review what we have recently learned about CTCs from pancreatic tumors, describing advances in their isolation and analysis and challenges to their clinical utility. We summarize technologies used to isolate CTCs from blood samples of patients with pancreatic cancer, including immunoaffinity and label-free physical attribute-based capture. We explain methods of CTC analysis and how findings from these studies might be used to detect cancer at earlier stages, monitor disease progression, and determine prognosis. We review studies that have expanded CTCs for testing of anticancer agents and how these approaches might be used to personalize treatment. Advances in the detection, isolation, and analysis of CTCs have increased our understanding of the dissemination and progression of pancreatic cancer. However, standardization of methodologies and prospective studies are needed for this emerging technology to have a significant effect on clinical care. PMID:27339829

  11. Developing effective tumor vaccines:basis,challenges and perspectives

    Institute of Scientific and Technical Information of China (English)

    XU Qingwen; CHEN Weifeng

    2007-01-01

    A remarkable advance in tumor immunology during the last decade is the elucidation of the antigenic basis of tumor recognition and destruction.A variety of tumor antigens have been identified using several strategies including conventional experiments and newly developed bioinformatics.Among these antigens,cancer/testis antigen (CT antigen) is considered to be the most promising target for immunotherapy by vaccination.Successful immunotherapy of tumors requires understanding of the natural relationship between the immune system and tumor in the status of differentiation,invasion and maturation.Continued progress in development of effective cancer vaccines depends on the identification of appropriate target antigens,the establishment of optimal immunization strategies without harmful autoimmune responses and the ability of manipulating tumor microenvironment to circumvent immune suppression and to augment the anti-tumor immune response.

  12. Biodistribution of the compounds BSH and BPA used for BNCT in four different tumor entities in relation to blood and normal tissues

    International Nuclear Information System (INIS)

    The success of boron neutron capture therapy (BNCT) relies on the selective delivery of a boronated compound to tumour cells. The compounds BSH and BPA are in use as experimental drugs in clinical trials, demonstrating some ability to target glioblastoma and melanoma. The aim of this study is to identify other tumor entities apart from melanoma and glioblastoma that may obtain benefit from BNCT using the 2 available drugs. The potential of applying both compounds subsequently to obtain a favourable absolute 10B concentration in the tumour and an optimised 10B-ratio between tumor, blood and healthy tissue was also evaluated. For the investigations different human tumours (glioblastoma (U87), melanoma (MV3), sarcoma (S3) and adenocarcinoma (PC-3) were transplanted subcutaneously at the right chest wall in nu/nu mice. Animals received either BSH (200 mg/kg) or BPA (700 mg/kg) or both compounds subsequently as intraperitoneal injection. The boron concentration in tissues was measured by prompt gamma ray spectroscopy. For all tissues evaluated but especially for tumor samples the measured values showed quite high standard deviations even under the very controlled experimental conditions applied in these experiments. Therefore, a considerable amount of analyses are necessary for a statistically reliable analysis. Preliminary results show significant differences in the accumulation of both compounds in the different tumour entities and in the different organs evaluated. After the application of BSH high boron concentrations have especially been found in the kidneys and liver, after application of BPA high concentrations were also found in the kidneys and the liver but also quite high values in the skin and the lung. The application of both drugs leads to higher absolute values that are however lower as expected assuming an additive increase of uptake

  13. Primary carcinoid tumor arising within mature teratoma of the kidney: report of a rare entity and review of the literature

    Directory of Open Access Journals (Sweden)

    Parwani Anil V

    2007-05-01

    Full Text Available Abstract Background Primary carcinoid tumor arising within mature teratoma of the kidney is extremely rare, and their clinicopathologic features are not well described. Our objective was to further define the clinical features and pathologic spectra of primary carcinoid tumor arising within mature teratoma of the kidney. Methods Six previously reported case reports were identified using MEDLINE and a subsequent bibliographic search of all pertinent reports and reviews was performed. We also searched the electronic medical archival records of our institution and identified one additional unreported case. Data were extracted on the demographics, predisposing factors, clinical presentation, radiographic features, gross pathology, microscopic pathology, immunophenotype, therapy, and outcome of each of these seven cases. Results Primary carcinoid tumor arising within mature teratoma of the kidney was found at a mean age of 41.4 years. Of the 7 cases, 3 were female and 4 were male. Two of the 7 cases (28.6% were associated with horseshoe kidney. It typically presented with abdominal pain without carcinoid syndrome. It typical radiologic appearance was well circumscribed partly calcified Bosniak II-III lesion. Histologically, the carcinoid tumor showed monotonous small round cells arranged in classic anastomosing cords/ribbons intermixed with solid nests. Surgery was curative, no additional treatment was required, no local recurrences occurred, and no metastases occurred in all 7 cases. The 3 cases with available outcome data were alive at the time of publication of their respective cases (mean, 5 months. Conclusion Primary carcinoid tumor arising within mature teratoma of the kidney is a rare tumor that typically presents with abdominal pain without carcinoid syndrome. It is not associated with local recurrence and metastasis, is surgically curable, and has excellent prognosis.

  14. Primary Neuroendocrine Tumor of the Parotid Gland: A Case Report and a Comprehensive Review of a Rare Entity.

    Science.gov (United States)

    Martínez-Sáez, Olga; Molina-Cerrillo, Javier; Moreno García Del Real, Carmen; Barberá Durban, Rafael; Díez, Juan J; Alonso-Gordoa, Teresa; Pulido, Enrique Grande

    2016-01-01

    Neuroendocrine tumors (NETs) comprise a heterogeneous group of malignancies from cells derived from the neural crest with neuroendocrine differentiation. Despite the differences in the site of origin, nomenclature, biological behavior, and functional status, NETs share certain ultrastructural and immunohistochemical features. NETs are relative rare tumors with an annual incidence of 5.76 new cases per 100.000 inhabitants and they usually appear in the gastrointestinal tract or in the pulmonary system. Head and neck NETs are uncommon with limited information regarding frequency, most of them showing small cell carcinoma features. NETs that arise from the salivary glands are exceedingly rare. Regardless of their low frequency, it is imperative to accurately differentiate these tumors from the much more common squamous cell carcinomas and from metastasis from another primary tumor due to the completely different therapeutic approaches and prognosis. The diagnosis is based on the recognition of the typical neuroendocrine architecture and immunohistochemical staining and on an exhaustive work-up. Hereby, we report a case of a moderately differentiated NET of the parotid gland that was treated with a complete parotidectomy. We summarize the clues that led to the final diagnosis and major strategies that were employed to manage the patient. We also perform a comprehensive review of the scarce available literature on this topic. PMID:27610258

  15. Somatostatinoma syndrome: a challenging differential diagnosis among pancreatic tumors

    Directory of Open Access Journals (Sweden)

    Paula Martinez Vianna

    2013-03-01

    Full Text Available Among the neuroendocrine neoplasia, the pancreatic somatostatin-producing tumors are very rare. Usually functional, these tumors produce the somatostatinoma syndrome, which encompasses diabetes mellitus, diarrhea/steatorrhoea, and cholelithiasis. Other symptoms may include dyspepsia, weight loss, anemia, and hypochlorhydria. All theses symptoms are explained by the inhibitory actions of the somatostatin released by tumoral cells originated from pancreatic delta cells or endocrine cells of the digestive tract. The diagnosis is easy to overlook since these symptoms are commonly observed in other more common syndromes. Besides the clinical features, diagnosis is based on serum determination of somatostatin, and imaging exams, such as ultrasound, computer tomography and positron emission tomography. Pathologic examination is characterized by the positivity of immunohistochemical reaction for synaptophysin, chromogranin, and somatostatin. These tumors can be classified according to tumor size, mitotic index, neural or vascular invasion, and distant metastases. The authors describe the case of a 61-year-old female patient who sought medical care because of a 6-month history of watery diarrhea, weight loss, and depression. She was diagnosed with diabetes mellitus 3 years ago. Imaging examination revealed a tumoral mass of 4 cm in its longest axis in the topography of the head of the pancreas and calculous cholecistopathy. The patient’s clinical status was unfavorable for a surgical approach. She died after 20 days of hospitalization. The definitive diagnosis was achieved with the autopsy findings, which disclosed a pancreatic somatostatinoma.

  16. Targeting JAK kinase in solid tumors: emerging opportunities and challenges.

    Science.gov (United States)

    Buchert, M; Burns, C J; Ernst, M

    2016-02-25

    Various human malignancies are characterized by excessive activation of the Janus family of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and STAT5. In the majority of solid tumors, this occurs in response to increased abundance of inflammatory cytokines in the tumor microenvironment prominently produced by infiltrating innate immune cells. Many of these cytokines share common receptor subunits and belong to the interleukin (IL)-6/IL-11, IL-10/IL-22 and IL-12/IL-23 families. Therapeutic inhibition of the JAK/STAT3 pathway potentially offers considerable benefit owing to the capacity of JAK/STAT3 signaling to promote cancer hallmarks in the tumor and its environment, including proliferation, survival, angiogenesis, tumor metabolism while suppressing antitumor immunity. This is further emphasized by the current successful clinical applications of JAK-specific small molecule inhibitors for the treatment of inflammatory disorders and hematopoietic malignancies. Here we review current preclinical applications for JAK inhibitors for the treatment of solid cancers in mice, with a focus on the most common malignancies emanating from oncogenic transformation of the epithelial mucosa in the stomach and colon. Emerging data with small molecule JAK-specific adenosine triphosphate-binding analogs corroborate genetic findings and suggest that interference with the JAK/STAT3 pathway may suppress the growth of the most common forms of sporadic colon cancers that arise from mutations of the APC tumor suppressor gene. Likewise inhibition of cytokine-dependent activation of the JAK/STAT3 pathway may also afford orthogonal treatment opportunities for other oncogene-addicted cancer cells that have gained drug resistance. PMID:25982279

  17. The Markyt visualisation, prediction and benchmark platform for chemical and gene entity recognition at BioCreative/CHEMDNER challenge.

    Science.gov (United States)

    Pérez-Pérez, Martin; Pérez-Rodríguez, Gael; Rabal, Obdulia; Vazquez, Miguel; Oyarzabal, Julen; Fdez-Riverola, Florentino; Valencia, Alfonso; Krallinger, Martin; Lourenço, Anália

    2016-01-01

    Biomedical text mining methods and technologies have improved significantly in the last decade. Considerable efforts have been invested in understanding the main challenges of biomedical literature retrieval and extraction and proposing solutions to problems of practical interest. Most notably, community-oriented initiatives such as the BioCreative challenge have enabled controlled environments for the comparison of automatic systems while pursuing practical biomedical tasks. Under this scenario, the present work describes the Markyt Web-based document curation platform, which has been implemented to support the visualisation, prediction and benchmark of chemical and gene mention annotations at BioCreative/CHEMDNER challenge. Creating this platform is an important step for the systematic and public evaluation of automatic prediction systems and the reusability of the knowledge compiled for the challenge. Markyt was not only critical to support the manual annotation and annotation revision process but also facilitated the comparative visualisation of automated results against the manually generated Gold Standard annotations and comparative assessment of generated results. We expect that future biomedical text mining challenges and the text mining community may benefit from the Markyt platform to better explore and interpret annotations and improve automatic system predictions.Database URL: http://www.markyt.org, https://github.com/sing-group/Markyt. PMID:27542845

  18. Low tracheal tumor and airway management: An anesthetic challenge

    Directory of Open Access Journals (Sweden)

    Richa Saroa

    2015-01-01

    Full Text Available We describe a case presenting with tracheal tumor wherein a Microlaryngeal tube was advanced into the trachea distal to the tumor for primary airway control followed by cannulation of both endobronchial lumen with 5.5 mm endotracheal tubes to provide independent lung ventilation post tracheal transection using Y- connector attached to anesthesia machine. The plan was formulated to provide maximal surgical access to the trachea while providing adequate ventilation at the same time. A 32 yrs non smoker male, complaining of cough, progressive dyspnea and hemoptysis was diagnosed to have a broad based mass in the trachea on computed tomography of chest. Bronchoscopy of the upper airway confirmed presence of the mass at a distance of 9 cms from the vocal cords, obstructing the tracheal lumen by three fourth of the diameter. The patient was scheduled to undergo the resection of the mass through anterolateral thoracotomy. We recommend the use of extralong, soft, small sized microlaryngeal surgery tube in tumors proximal to carina, for securing the airway before the transection of trachea and bilateral endobronchial intubation with small sized cuffed endotracheal tubes for maintenance of ventilation after the transection of trachea in patients with mass in the lower trachea.

  19. Multicystic nephroma masquerading as Wilms′ tumor: A clinical diagnostic challenge

    Directory of Open Access Journals (Sweden)

    Bhupendra R Mehra

    2011-01-01

    Full Text Available Multicystic nephroma (MCN is an uncommon, non-heritable, unilateral, benign tumor that represents 2-3% of all primary renal tumors in the pediatric age group. It is characterized by bimodal age incidence with 50% of cases seen in children less than four years of age. Presented here is an 8-month-old boy with asymptomatic, gradually progressive renal lump of two months duration, with no other complaints. Ultrasound of the abdomen showed a well-defined multi-septated cystic mass involving whole of the kidney. Computerized Tomography (CT scan revealed a unilateral cystic lesion involving almost the entire left kidney. Keeping in mind the age, clinical presentation and radiological appearance, the possibility of cystic variant of Wilms′ tumor could not be ruled out pre-operatively. An elective left nephrectomy was done. The histopathological report revealed MCN of the left kidney. Only a few cases have been reported from India. We report here one such pediatric case.

  20. Tumor lysis syndrome in the emergency department: challenges and solutions

    Directory of Open Access Journals (Sweden)

    Ñamendys-Silva SA

    2015-08-01

    Full Text Available Silvio A Ñamendys-Silva,1,2 Juan M Arredondo-Armenta,1 Erika P Plata-Menchaca,2 Humberto Guevara-García,1 Francisco J García-Guillén,1 Eduardo Rivero-Sigarroa,2 Angel Herrera-Gómez,1 1Department of Critical Care Medicine, Instituto Nacional de Cancerología, 2Department of Critical Care Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico Abstract: Tumor lysis syndrome (TLS is the most common oncologic emergency. It is caused by rapid tumor cell destruction and the resulting nucleic acid degradation during or days after initiation of cytotoxic therapy. Also, a spontaneous form exists. The metabolic abnormalities associated with this syndrome include hyperkalemia, hyperphosphatemia, hypocalcemia, hyperuricemia, and acute kidney injury. These abnormalities can lead to life-threatening complications, such as heart rhythm abnormalities and neurologic manifestations. The emergency management of overt TLS involves proper fluid resuscitation with crystalloids in order to improve the intravascular volume and the urinary output and to increase the renal excretion of potassium, phosphorus, and uric acid. With this therapeutic strategy, prevention of calcium phosphate and uric acid crystal deposition within renal tubules is achieved. Other measures in the management of overt TLS are prescription of hypouricemic agents, renal replacement therapy, and correction of electrolyte imbalances. Hyperkalemia should be treated quickly and aggressively as its presence is the most hazardous acute complication that can cause sudden death from cardiac arrhythmias. Treatment of hypocalcemia is reserved for patients with electrocardiographic changes or symptoms of neuromuscular irritability. In patients who are refractory to medical management of electrolyte abnormalities or with severe cardiac and neurologic manifestations, early dialysis is recommended.Keywords: tumor lysis syndrome, emergency department, emergency

  1. Challenges in circulating tumor cell detection by the CellSearch system

    NARCIS (Netherlands)

    Andree, K.C.; Dalum, van G.; Terstappen, L.W.M.M.

    2016-01-01

    Enumeration and characterization of circulating tumor cells (CTC) hold the promise of a real time liquid biopsy. They are however present in a large background of hematopoietic cells making their isolation technically challenging. In 2004, the CellSearch system was introduced as the first and only F

  2. Diagnostic and Therapeutic Challenges of a Large Pleural Inflammatory Myofibroblastic Tumor

    Directory of Open Access Journals (Sweden)

    Judith Loeffler-Ragg

    2012-01-01

    Full Text Available We report a 48-year-old woman with a pleural pseudoneoplasm requiring different diagnostic and therapeutic strategies. After initial presentation with increasing dyspnoea, temperature, dry cough, and interscapular pain diagnostic processing showed a large mediastinal mass with marked pleural effusion and high metabolic activity in the 18F-FDG-PET/CT. Extensive CT-guided biopsy of the tumor reaching from the visceral pleura into the right upper lobe revealed no malignancy, but a marked inflammatory tissue reaction containing foam cells. Initial empiric antibiotic therapy was temporarily successful. However, in the further course the mass relapsed and was resistant to antibiotics and a corticosteroid trial. With the working hypothesis of an inflammatory myofibroblastic tumor the patient underwent surgical tumor resection, finally confirming the suspected diagnosis. Due to residual disease intravenous immunoglobulins were administered leading to sustained response. This case with a pleural localisation of a large inflammatory pseudotumor with responsiveness to immunomodulation after incomplete resection extends the reported spectrum of thoracopulmonary manifestations of this rare entity.

  3. REX: Explaining Relationships between Entity Pairs

    CERN Document Server

    Fang, Lujun; Yu, Cong; Bohannon, Philip

    2011-01-01

    Knowledge bases of entities and relations (either constructed manually or automatically) are behind many real world search engines, including those at Yahoo!, Microsoft, and Google. Those knowledge bases can be viewed as graphs with nodes representing entities and edges representing (primary) relationships, and various studies have been conducted on how to leverage them to answer entity seeking queries. Meanwhile, in a complementary direction, analyses over the query logs have enabled researchers to identify entity pairs that are statistically correlated. Such entity relationships are then presented to search users through the "related searches" feature in modern search engines. However, entity relationships thus discovered can often be "puzzling" to the users because why the entities are connected is often indescribable. In this paper, we propose a novel problem called "entity relationship explanation", which seeks to explain why a pair of entities are connected, and solve this challenging problem by integra...

  4. Tumorer

    DEFF Research Database (Denmark)

    Prause, J.U.; Heegaard, S.

    2005-01-01

    oftalmologi, øjenlågstumorer, conjunctivale tumorer, malignt melanom, retinoblastom, orbitale tumorer......oftalmologi, øjenlågstumorer, conjunctivale tumorer, malignt melanom, retinoblastom, orbitale tumorer...

  5. Visualization of tumor vascular reactivity in response to respiratory challenges by optical coherence tomography (Conference Presentation)

    Science.gov (United States)

    Kim, Hoon Sup; Lee, Songhyun; Lee, Kiri; Eom, Tae Joong; Kim, Jae G.

    2016-02-01

    We previously reported the potential of using vascular reactivity during respiratory challenges as a marker to predict the response of breast tumor to chemotherapy in a rat model by using a continuous wave near-infrared spectroscopy. However, it cannot visualize how the vascular reactivity from tumor vessel can predict the tumor response to its treatment. In this study, we utilized a spectral domain optical coherence tomography (SD-OCT) system to visualize vascular reactivity of both tumor and normal vasculature during respiratory challenges in a mouse model. We adapted intensity based Doppler variance algorithm to draw angiogram from the ear of mouse (8-week-old Balb/c nu/nu). Animals were anesthetized using 1.5% isoflurane, and the body temperature was maintained by a heating pad. Inhalational gas was switched from air (10min) to 100% oxygen (10min), and a pulse oximeter was used to monitor arterial oxygen saturation and heart rate. OCT angiograms were acquired 5 min after the onset of each gas. The vasoconstriction effect of hyperoxic gas on vasculature was shown by subtracting an en-face image acquired during 100% oxygen from the image acquired during air inhalation. The quantitative change in the vessel diameter was measured from the en-face OCT images of the individual blood vessels. The percentage of blood vessel diameter reduction varied from 1% to 12% depending on arterial, capillary, or venous blood vessel. The vascular reactivity change during breast tumor progression and post chemotherapy will be monitored by OCT angiography.

  6. Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects

    Directory of Open Access Journals (Sweden)

    Yelei Guo

    2016-01-01

    Full Text Available Recent studies have highlighted the successes of chimeric antigen receptor-modified T- (CART- cell-based therapy for B-cell malignancies, and early phase clinical trials have been launched in recent years. The few published clinical studies of CART cells in solid tumors have addressed safety and feasibility, but the clinical outcome data are limited. Although antitumor effects were confirmed in vitro and in animal models, CART-cell-based therapy still faces several challenges when directed towards solid tumors, and it has been difficult to achieve the desired outcomes in clinical practice. Many studies have struggled to improve the clinical responses to and benefits of CART-cell treatment of solid tumors. In this review, the status quo of CART cells and their clinical applications for solid tumors will be summarized first. Importantly, we will suggest improvements that could increase the therapeutic effectiveness of CART cells for solid tumors and their future clinical applications. These interventions will make treatment with CART cells an effective and routine therapy for solid tumors.

  7. Genital soft tissue tumors.

    Science.gov (United States)

    Schoolmeester, John K; Fritchie, Karen J

    2015-07-01

    Mesenchymal neoplasms of the vulvovaginal and inguinoscrotal regions are among the most diagnostically challenging specimens in the pathology laboratory owing largely to their unique intersection between general soft tissue tumors and relatively genital-specific mesenchymal tumors. Genital stromal tumors are a unique subset of soft tissue tumors encountered at this location, and this group includes fibroepithelial stromal polyp, superficial (cervicovaginal) myofibroblastoma, cellular angiofibroma, mammary-type myofibroblastoma, angiomyofibroblastoma and aggressive angiomyxoma. Aside from the striking morphologic and immunophenotypic similarity that is seen with these entities, there is evidence that a subset of genital stromal tumors may be linked genetically. This review will focus on simplifying this group of tumors and provide the pathologist or dermatopathologist with practical management information. Smooth muscle tumors of the external genitalia will also be discussed.

  8. Therapeutic potential and challenges of Natural killer cells in treatment of solid tumors

    Directory of Open Access Journals (Sweden)

    Andrea eGras Navarro

    2015-04-01

    Full Text Available Natural killer (NK cells are innate lymphoid cells that hold tremendous potential for effective immunotherapy for a broad range of cancers. Due to the mode of NK cell killing requiring one–to-one target engagement and site directed release of cytolytic granules, the therapeutic potential of NK cells has been most extensively explored in hematological malignancies. However, their ability to precisely kill antibody coated cells, cancer stem cells (CSCs and genotoxically altered cells, while maintaining tolerance to healthy cells makes them appealing therapeutic effectors for all cancer forms, including metastases. Due to their release of pro-inflammatory cytokines, NK cells may potently reverse the anti-inflammatory tumor microenvironment (TME and augment adaptive immune responses by promoting differentiation, activation and/ or recruitment of accessory immune cells to sites of malignancy. Nevertheless, integrated and coordinated mechanisms of subversion of NK cell activity against the tumor and its microenvironment exist. Although our understanding of the receptor ligand interactions that regulate NK cell functionality has evolved remarkably, the diversity of ligands and receptors is complex, as is their mechanistic foundations in regulating NK cell function. In this article, we review the literature and highlight how the TME manipulates the NK cell phenotypes, genotypes and tropism to evade tumor recognition and elimination. We discuss counter strategies that may be adopted to augment the efficacy of NK cell anti-tumor surveillance, the clinical trials that have been undertaken so far in solid malignancies, critically weighing the challenges and opportunities with this approach.

  9. Prospects and challenges of quantitative phase imaging in tumor cell biology

    Science.gov (United States)

    Kemper, Björn; Götte, Martin; Greve, Burkhard; Ketelhut, Steffi

    2016-03-01

    Quantitative phase imaging (QPI) techniques provide high resolution label-free quantitative live cell imaging. Here, prospects and challenges of QPI in tumor cell biology are presented, using the example of digital holographic microscopy (DHM). It is shown that the evaluation of quantitative DHM phase images allows the retrieval of different parameter sets for quantification of cellular motion changes in migration and motility assays that are caused by genetic modifications. Furthermore, we demonstrate simultaneously label-free imaging of cell growth and morphology properties.

  10. Sublingual vaccination induces mucosal and systemic adaptive immunity for protection against lung tumor challenge.

    Directory of Open Access Journals (Sweden)

    Shailbala Singh

    Full Text Available Sublingual route offers a safer and more practical approach for delivering vaccines relative to other systemic and mucosal immunization strategies. Here we present evidence demonstrating protection against ovalbumin expressing B16 (B16-OVA metastatic melanoma lung tumor formation by sublingual vaccination with the model tumor antigen OVA plus synthetic glycolipid alpha-galactosylceramide (aGalCer for harnessing the adjuvant potential of natural killer T (NKT cells, which effectively bridge innate and adaptive arms of the immune system. The protective efficacy of immunization with OVA plus aGalCer was antigen-specific as immunized mice challenged with parental B16 tumors lacking OVA expression were not protected. Multiple sublingual immunizations in the presence, but not in the absence of aGalCer, resulted in repeated activation of NKT cells in the draining lymph nodes, spleens, and lungs of immunized animals concurrent with progressively increasing OVA-specific CD8+ T cell responses as well as serum IgG and vaginal IgA levels. Furthermore, sublingual administration of the antigen only in the presence of the aGalCer adjuvant effectively boosted the OVA-specific immune responses. These results support potential clinical utility of sublingual route of vaccination with aGalCer-for prevention of pulmonary metastases.

  11. Entity Ranking in Wikipedia

    CERN Document Server

    Vercoustre, Anne-Marie; Pehcevski, Jovan

    2007-01-01

    The traditional entity extraction problem lies in the ability of extracting named entities from plain text using natural language processing techniques and intensive training from large document collections. Examples of named entities include organisations, people, locations, or dates. There are many research activities involving named entities; we are interested in entity ranking in the field of information retrieval. In this paper, we describe our approach to identifying and ranking entities from the INEX Wikipedia document collection. Wikipedia offers a number of interesting features for entity identification and ranking that we first introduce. We then describe the principles and the architecture of our entity ranking system, and introduce our methodology for evaluation. Our preliminary results show that the use of categories and the link structure of Wikipedia, together with entity examples, can significantly improve retrieval effectiveness.

  12. Leiomyosarcoma of the Penis, an Exceptional Entity

    OpenAIRE

    Edwin Javier Romero Gonzalez; Marenco Jiménez, José L.; Mayorga Pineda, Maria P.; Alfonso Martínez Morán; Jesús Castiñeiras Fernández

    2015-01-01

    In tumors of the penis, mesenchymal tumors are extremely rare and within them, sarcomas are exceptional. We report a patient with a sarcomatous lesion treated with conservative surgery with good surgical outcome and the review of the literature, to present the latest advances in the treatment of this unusual entity.

  13. TCR-engineered T cells meet new challenges to treat solid tumors: choice of antigen, T cell fitness and sensitisation of tumor milieu (review

    Directory of Open Access Journals (Sweden)

    Andre eKunert

    2013-11-01

    Full Text Available Adoptive transfer of T cells gene-engineered with antigen-specific T cell receptors (TCRs has proven its feasibility and therapeutic potential in the treatment of malignant tumors. To ensure further clinical development of TCR gene therapy, it is necessary to target immunogenic epitopes that are related to oncogenesis and selectively expressed by tumor tissue, and implement strategies that result in optimal T cell fitness. In addition, in particular for the treatment of solid tumors, it is equally necessary to include strategies that counteract the immune-suppressive nature of the tumor micro-environment. Here, we will provide an overview of the current status of TCR gene therapy, and redefine the following three challenges of improvement: ‘choice of target antigen’; ‘fitness of T cells’; and ‘sensitisation of tumor milieu’. We will categorize and discuss potential strategies to address each of these challenges, and argue that advancement of clinical TCR gene therapy critically depends on developments towards each of the three challenges.

  14. Calcifying nested stromal-epithelial tumor (CNSET) of the liver: a newly recognized entity to be considered in the radiologist's differential diagnosis.

    Science.gov (United States)

    Schaffer, Lauren R; Shehata, Bahig M; Yin, Julie; Schemankewitz, Erwin; Alazraki, Adina

    2016-01-01

    Calcifying nested stromal-epithelial tumor (CNSET), an extremely rare tumor found in the liver, was first described in 2001 by Ishak et al. The characteristic imaging features include large size, well-circumscribed, enhancing mass with calcification. To our knowledge, since 2001, there have been 29 reported. Typically arising from the right hepatic lobe, it is primarily found in children and shows clear predilection for females. Emphasizing imaging, we report a 14-year-old female with Beckwith-Wiedemann syndrome who presented with CNSET. PMID:26589005

  15. Programming Drupal 7 entities

    CERN Document Server

    Michael, Sammy

    2013-01-01

    The book follows a standard tutorial-based approach to create, retrieve, update, and delete Drupal 7 entities, their properties and fields.Programming Drupal 7 Entities is perfect for intermediate or advanced developers new to Drupal entity development who are looking to get a good grounding in how to code using the new paradigm. It's assumed that you will have some experience in PHP development already, and being vaguely familiar with Drupal, GIT, and Drush will also help.

  16. Tumor

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008479 Preliminary study of MR elastography in brain tumors. XU Lei(徐磊), et al.Neurosci Imaging Center, Beijing Tiantan Hosp, Capital Med Univ, Beijing 100050.Chin J Radiol 2008;42(6):605-608. Objective To investigate the potential values of magnetic resonance elastography (MRE) for evaluating the brain tumor consistency in vivo. Methods Fourteen patients with known solid brain tumor (5 male, 9 female; age range: 16-63 years)

  17. Pure primary small cell carcinoma of urinary bladder: A rare diagnostic entity

    Directory of Open Access Journals (Sweden)

    Sonia Gon

    2013-01-01

    Full Text Available Small cell carcinoma of the bladder is a rare, aggressive, poorly differentiated neuroendocrine neoplasm accounting for only 0.3-0.7% of all bladder tumors. Since the tumor is very rare, pathogenesis is uncertain. Small cell carcinomas of the urinary bladder are mixed with classic urothelial carcinomas or adenocarcinomas of the bladder in 68% cases, making pure primary small cell carcinoma even a rarer entity. The unknown etiology and natural history of small cell carcinoma of the urinary bladder represent a challenge both to the pathologist and urologists for its diagnosis and treatment, respectively.

  18. A case of bronchiectasis needing lung isolation for cerebello pontine angle tumor excision: Anesthetic challenges.

    Science.gov (United States)

    Srinivasan, C; Kurian, G P; Mariappan, R

    2016-01-01

    The main goals of neuroanesthesia are the maintenance of adequate cerebral perfusion pressure, avoidance of hypercarbia, hypoxemia, and to provide better brain relaxation. Providing anesthesia for a patient with bronchiectasis needing lung isolation for craniotomy can be challenging. A 56-year-old male patient, case of right lung bronchiectasis with a right cerebello pontine angle tumor underwent excision in the left lateral position. Since he had severe bronchiectasis of the right lung, we had isolated the right lung using right-sided double lumen tube to avoid spillage. Intraoperative split lung test was performed to assess the right lung contribution on carbon dioxide (CO2) elimination and found that there was a significant contribution from the right lung. Hence, both lungs were ventilated to control CO2. The importance of lung isolation to prevent spillage and avoidance of one lung ventilation to control the arterial CO2 are highlighted in this case report. By providing a balanced anesthetic keeping both, the neurosurgical and thoracic concerns are important for better postoperative outcome. PMID:27375400

  19. A case of bronchiectasis needing lung isolation for cerebello pontine angle tumor excision: Anesthetic challenges

    Directory of Open Access Journals (Sweden)

    C Srinivasan

    2016-01-01

    Full Text Available The main goals of neuroanesthesia are the maintenance of adequate cerebral perfusion pressure, avoidance of hypercarbia, hypoxemia, and to provide better brain relaxation. Providing anesthesia for a patient with bronchiectasis needing lung isolation for craniotomy can be challenging. A 56-year-old male patient, case of right lung bronchiectasis with a right cerebello pontine angle tumor underwent excision in the left lateral position. Since he had severe bronchiectasis of the right lung, we had isolated the right lung using right-sided double lumen tube to avoid spillage. Intraoperative split lung test was performed to assess the right lung contribution on carbon dioxide (CO 2 elimination and found that there was a significant contribution from the right lung. Hence, both lungs were ventilated to control CO 2 . The importance of lung isolation to prevent spillage and avoidance of one lung ventilation to control the arterial CO 2 are highlighted in this case report. By providing a balanced anesthetic keeping both, the neurosurgical and thoracic concerns are important for better postoperative outcome.

  20. Moving Hands, Moving Entities

    Science.gov (United States)

    Setti, Annalisa; Borghi, Anna M.; Tessari, Alessia

    2009-01-01

    In this study we investigated with a priming paradigm whether uni and bimanual actions presented as primes differently affected language processing. Animals' (self-moving entities) and plants' (not self-moving entities) names were used as targets. As prime we used grasping hands, presented both as static images and videos. The results showed an…

  1. Immature teratoma with microscopic yolk sac tumor: A case of diagnostic challenge on histology

    OpenAIRE

    Sonali R Saraf; Madhu Chaturvedi; Manisha Khare; Alka Kalgutkar

    2016-01-01

    An adolescent girl with raised alpha-fetoprotein (AFP) levels presented with a left-sided large solid ovarian mass. Microscopically, the tumor was composed of a variety of immature and mature tissues derived from the three germ layers having very sparse (single focus of) immature neuroepithelium. Few areas also showed the presence of a reticular pattern of yolk sac tumor (YST). Hence, the tumor was diagnosed as immature teratoma with microscopic foci of yolk sac elements. After 6 months of ci...

  2. Programming Entity Framework

    CERN Document Server

    Lerman, Julia

    2010-01-01

    Get a thorough introduction to ADO.NET Entity Framework 4 -- Microsoft's core framework for modeling and interacting with data in .NET applications. The second edition of this acclaimed guide provides a hands-on tour of the framework latest version in Visual Studio 2010 and .NET Framework 4. Not only will you learn how to use EF4 in a variety of applications, you'll also gain a deep understanding of its architecture and APIs. Written by Julia Lerman, the leading independent authority on the framework, Programming Entity Framework covers it all -- from the Entity Data Model and Object Service

  3. Common Diagnostic Challenges in the Histopathologic Diagnosis of Neuroendocrine Lung Tumors: A Case Report

    Directory of Open Access Journals (Sweden)

    Monica Valente

    2010-07-01

    Full Text Available Bronchopulmonary neuroendocrine tumors are an uncommon group of neoplasms, accounting for about 20% of all lung carcinomas, arising from stem cells of the bronchial epithelium known as Kulchitsky cells. In the past, these tumors were grouped among benign or less aggressive malignant pulmonary tumors. Currently, according to the 2004 World Health Organization categorization, these tumors are separated into 4 subtypes characterized by increasing biologic aggressiveness: low-grade (typical carcinoid; TC, intermediate-grade (atypical carcinoid; AC and high-grade (large-cell neuroendocrine carcinoma, LCNEC, and small-cell lung carcinoma, SCLC. They differ by morphologic, immunohistochemical and structural features. At histopathologic analysis, these tumors share progressive increase in a number of mitotic figures per 10 high-power fields and in the extent of necrosis, with TC having the lowest values and SCLC having the highest. TCs and ACs make up approximately 1–2% of all primary lung tumors. Differentiating ACs from TCs or LCNEC and SCLC is clinically important because the treatment modalities and prognoses for these types of tumors are different. We report a case of misdiagnosis of bronchopulmonary neuroendocrine tumor in a young woman which has heavily influenced her clinical history.

  4. Targeting cancer cells in the tumor microenvironment: opportunities and challenges in combinatorial nanomedicine.

    Science.gov (United States)

    Linton, Samuel S; Sherwood, Samantha G; Drews, Kelly C; Kester, Mark

    2016-01-01

    Cancer therapies of the future will rely on synergy between drugs delivered in combination to achieve both maximum efficacy and decreased toxicity. Nanoscale drug delivery vehicles composed of highly tunable nanomaterials ('nanocarriers') represent the most promising approach to achieve simultaneous, cell-selective delivery of synergistic ratios of combinations of drugs within solid tumors. Nanocarriers are currently being used to co-encapsulate and deliver synergistic ratios of multiple anticancer drugs to target cells within solid tumors. Investigators exploit the unique environment associated with solid tumors, termed the tumor microenvironment (TME), to make 'smart' nanocarriers. These sophisticated nanocarriers exploit the pathological conditions in the TME, thereby creating highly targeted nanocarriers that release their drug payload in a spatially and temporally controlled manner. The translational and commercial potential of nanocarrier-based combinatorial nanomedicines in cancer therapy is now a reality as several companies have initiated human clinical trials. PMID:26153136

  5. Rare incidence of yolk sac tumor in pregnancy posing management challenge: a case report

    Directory of Open Access Journals (Sweden)

    Chanda Rai

    2016-08-01

    Full Text Available Yolk sac tumor of the ovary, although rare but highly malignant, when diagnosed in a pregnant woman is difficult to manage because of risks involved to the fetus but with the advent of surgery and chemotherapy prognosis has greatly improved. A G3P2L2, 35 years old, woman got admitted at 8 months amenorrhea with absent fetal movements since two days with labor pains. She carried an ultrasound report, done at a private clinic which showed intrauterine death of fetus along with a pelvic tumor. Her CT done at our hospital confirmed a pelvic tumor mass posterior to the uterus and in close proximity with the rectum. A laparotomy was planned for her as the pelvic mass was preventing the descent of fetal head thus hindering vaginal delivery. Biopsy from the tumor mass revealed yolk sac tumor of the ovary. Her general condition was poor with low Hb levels and deranged LFT and KFT and was shifted to ICU for intensive care but she could not survive despite the best efforts. Early diagnosis of ovarian yolk sac tumor in pregnancy leads to timely intervention in the forms of surgery and chemotherapy which greatly improves the survival rates. [Int J Reprod Contracept Obstet Gynecol 2016; 5(8.000: 2853-2855

  6. Immature teratoma with microscopic yolk sac tumor: A case of diagnostic challenge on histology

    Directory of Open Access Journals (Sweden)

    Sonali R Saraf

    2016-01-01

    Full Text Available An adolescent girl with raised alpha-fetoprotein (AFP levels presented with a left-sided large solid ovarian mass. Microscopically, the tumor was composed of a variety of immature and mature tissues derived from the three germ layers having very sparse (single focus of immature neuroepithelium. Few areas also showed the presence of a reticular pattern of yolk sac tumor (YST. Hence, the tumor was diagnosed as immature teratoma with microscopic foci of yolk sac elements. After 6 months of cisplatin-based chemotherapy, she developed a recurrence which was composed of mature teratoma on histology. In this case, the single focus of immature neuroepithelium caused a difficulty in labeling this tumor as an immature teratoma which otherwise resembled a mature teratoma. The raised AFP levels suggested the presence of yolk sac element, the classical form of which was seen at microscopy in only a few areas. As compared to the markedly elevated serum AFP levels, the classical yolk sac tumorous area was very limited thus advocating the view that differentiated glands with subnuclear vacuoles similar to immature endoderm represent well-differentiated forms of YST.[1

  7. Online Counseling: New Entity, New Challenges

    Science.gov (United States)

    Barnett, Jeffrey E.

    2005-01-01

    Mallen, Vogel, and colleagues explore the developing field of online counseling from the unique perspective of counseling psychology. They examine the body of available research and relevant clinical, ethical, legal, and practical issues and make recommendations for counseling psychologists who desire to participate in online counseling. This…

  8. Pelvic fibromatoses--a rare gynecological entity.

    Science.gov (United States)

    Buckshee, K; Mittal, S; Agarwal, N; Chellani, M

    1988-06-01

    A rare case of pelvic fibromatoses is reported. This condition is rarely encountered in gynecological practice but when encountered, creates a diagnostic and therapeutic challenge. The reported patient highlights the difficulties encountered in surgical excision (done twice) and illustrates the local aggressive growth behavior of this entity.

  9. Mastering entity framework

    CERN Document Server

    Singh, Rahul Rajat

    2015-01-01

    This book is for .NET developers who are developing data-driven applications using ADO.NET or other data access technologies. This book is going to give you everything you need to effectively develop and manage data-driven applications using Entity Framework.

  10. Primary primitive neuroectodermal tumor of kidney: A rare case report with diagnostic challenge

    Directory of Open Access Journals (Sweden)

    Sunita Kakkar

    2014-01-01

    Full Text Available Primary primitive neuroectodermal tumors (PNETs of the kidney are quite rare and can be mistaken for a wide variety of other small round blue cell tumors which includes rhabdomyosarcoma, Wilm′s tumor, carcinoid, neuroblastoma, clear cell sarcoma of the kidney, lymphoma etc. Renal Ewings/PNET can occur in the age group from 4 to 61 years. Approximately, 90% of Ewing sarcoma (ES/PNET have a specific t(11;22 which results in a chimeric EWS-FLI-1 fusion protein. Immunohistochemical for the carboxy-terminus of FLI-1 is sensitive and highly specific for the diagnosis of ES/PNET. Herein, we have an interesting presentation in a 23-year-old male who came with neck pain and progressive quadriparesis and was diagnosed as a case of poorly differentiated malignant tumor with a differential of lymphoma versus metastatic renal cell carcinoma. The patient′s condition deteriorated fast and he had a rapid downhill course. The final diagnosis of Ewings/PNET was confirmed at autopsy.

  11. Primary osteoclast-like giant cell tumor of parotid gland: A rare extraskeletal presentation with diagnostic challenges

    Science.gov (United States)

    Singh, Ritika; Zaheer, Sufian; Mandal, Ashish K

    2016-01-01

    Primary osteoclast-like giant cell tumor (OC-GCT) has been rarely described in extraskeletal sites. The diagnosis primarily hinges on the detection of giant cells. However, these giant cells are also seen in many giant cell lesions, thus creating diagnostic confusion and dilemma. Here, we describe a rare case of a 24-year-old male with primary extraskeletal, OC-GCT presenting as a swelling in the right parotid region and highlight its cytological, histological and immunohistochemical characteristics with diagnostic challenges. PMID:27601838

  12. Challenges in management of phyllodes tumors of the breast: A retrospective analysis of 150 patients

    Directory of Open Access Journals (Sweden)

    P Ramakant

    2013-01-01

    Full Text Available Introduction: Phyllodes tumors (PT of the breast seem to get pre-operatively misdiagnosed as fibroadenomas resulting in inadequate resections and high local recurrence rates. Materials and Methods: Data of 150 patients with PT of the breast managed from January, 2003 to February, 2013 were retrospectively analyzed. Statistical analysis performed using SPSS version 17 (Pearson Chi-square test and analysis of variance test for analysis. Aim: The aim of this study is to compare clinico-pathological profile and recurrence rates in patients with benign (B, borderline malignant (BL and malignant (M PT. Results: In a total of 150 patients with PT (n = 77 B, n = 24 BL, n = 49 M, mean age was 36.92, 44.04 and 40.46 years respectively (P 0.015 and mean tumor size being 8.15 cm, 14.7 cm and 12.9 cm respectively (P 0.000. Pre-operatively cytology suggestive of PT in 24% patients with B PT and 63% in M PT; core tissue biopsy suggestive of PT in 85.4% patients with B PT and 100% in M PT. Recurrence seen in 34.7% out of which 32.7% were post-lumpectomy performed elsewhere. Majority of B PT had lumpectomy (49.3%/wide local excision (WLE, 31.2% compared with M PT where 55.1% had simple mastectomy (SM due to large tumor size. Local recurrence was more in M PT (53% compared with B PT (20%. We found recurrence rates in L (39.3% compared with WLE (27.3% and SM (33.9% (P 0.049. Conclusions: Larger tumor size, incomplete resection and M/BL histology predicted higher recurrence in PT. Core biopsy is much more accurate than fine needle cytology in the diagnosis.

  13. The Challenging Diagnosis of Pancreatic Masses: Not All Tumors Are Cancers

    OpenAIRE

    Alessandro Morotti; Dario Gned; Leonardo Di Martino; Gaetano Cristaldi; Anna Alì; Paolo Nicoli; Andrea Veltri; Angelo Guerrasio

    2015-01-01

    In the elderly patients, where biopsy-induced complications could outweigh the benefit, the identification of pancreatic masses is generally referred to as a synonymous of pancreatic cancer and patients are dismissed with no further options than palliative and supportive care. Notwithstanding, not all pancreatic tumors are cancers and therefore alternative diagnoses need to be investigated, especially when patients are unfit for invasive diagnostic procedures. Here, we report a case of an age...

  14. A generic open world named entity disambiguation approach for tweets

    NARCIS (Netherlands)

    Habib, M.B.; Keulen, van M.

    2013-01-01

    Social media is a rich source of information. To make use of this information, it is sometimes required to extract and disambiguate named entities. In this paper we focus on named entity disambiguation (NED) in twitter messages. NED in tweets is challenging in two ways. First, the limited length of

  15. Ectopic duodenal insulinoma: a very rare and challenging tumor type. Description of a case and review of the literature.

    Science.gov (United States)

    La Rosa, Stefano; Pariani, Dario; Calandra, Calogera; Marando, Alessandro; Sessa, Fausto; Cortese, Ferdinando; Capella, Carlo

    2013-12-01

    Although most insulinomas are located in the pancreas, very rare ectopic cases have been described in the spleen, perisplenic tissue, duodenohepatic ligament, and adjacent to the ligament of Treitz. Moreover, three cases located in the duodenum have also been reported in the English literature. Ectopic insulinomas represent challenging neoplasms with clinical implications mainly due to the difficulties in their pre-operatory diagnosis and localization. In the present paper, we describe the fourth ectopic duodenal insulinoma so far reported. A 75-year-old woman presented at clinical observation due to neuroglycopenic symptoms that disappeared after glucose intake. Tumor was localized in the second portion of the duodenum in front of the papilla of Vater and was surgically enucleated. Microscopically, it was composed of monomorphic cells with eosinophilic cytoplasm arranged in trabecular and lobular patterns and diffusely positive for insulin, proinsulin, amylin, and PDX1. About 30 % of tumor cells also showed immunoreactivity for somatostatin, while no positivity for glucagon, pancreatic polypeptide, gastrin, serotonin, and somatostatin receptor subtype 2A was found. The Ki67 proliferative index was 1 %. We have also reviewed the literature on this topic to give the reader a comprehensive overview of this very rare tumor type. PMID:24006218

  16. Challenges of implementation and implementation research: Learning from an intervention study designed to improve tumor registry reporting

    Science.gov (United States)

    McAlearney, Ann Scheck; Walker, Daniel M; Livaudais-Toman, Jennifer; Parides, Michael; Bickell, Nina A

    2016-01-01

    Objectives: Implementation of interventions designed to improve the quality of medical care often proceeds differently from what is planned. Improving existing conceptual models to better understand the sources of these differences can help future projects avoid these pitfalls and achieve desired effectiveness. To inform an adaptation of an existing theoretical model, we examined unanticipated changes that occurred in an intervention designed to improve reporting of adjuvant therapies for breast cancer patients at a large, urban academic medical center. Methods: Guided by the complex innovation implementation conceptual framework, our study team observed and evaluated the implementation of an intervention designed to improve reporting to a tumor registry. Findings were assessed against the conceptual framework to identify boundary conditions and modifications that could improve implementation effectiveness. Results: The intervention successfully increased identification of the managing medical oncologist and treatment reporting. During implementation, however, unexpected external challenges including hospital acquisitions of community practices and practices’ responses to government incentives to purchase electronic medical record systems led to unanticipated changes and associated threats to implementation. We present a revised conceptual model that incorporates the sources of these unanticipated challenges. Conclusion: This report of our experience highlights the importance of monitoring implementation over time and accounting for changes that affect both implementation and measurement of intervention impact. In this article, we use our study to examine the challenges of implementation research in health care, and our experience can help future implementation efforts.

  17. Load of challenge Marek's disease virus DNA in blood as a criterion for early diagnosis of Marek's disease tumors.

    Science.gov (United States)

    Gimeno, Isabel M; Cortes, Aneg L; Silva, R F

    2008-06-01

    Outbreaks of Marek's disease (MD) in vaccinated flocks still occur sporadically and lead to economic losses. Unfortunately, adequate methods to predict MD outbreaks are lacking. In the present study, we have evaluated whether high load of challenge MD virus (MDV) DNA in peripheral blood could aid in the early diagnosis of MD and in monitoring efficacy of vaccines against MD. One experiment was conducted to simulate field conditions by combining various vaccines (turkey herpesvirus [HVT] and HVT + MDV serotype 2 [SB1]) and challenge viruses (GA, Md5, and 648A). Vaccine efficacy among our experimental groups ranged from 13.3% to 94.2%. Each chicken was sampled three times during the length of the experiment (3, 5, and 15 wk postchallenge [wpc]), and gross lesions were evaluated in chickens that died and at termination of the experiment. DNA was extracted from whole blood and buffy coats from each sample, and the load of challenge MDV DNA and HVT DNA were quantified by real-time polymerase chain reaction. Chickens that developed MD by the end of the experiment had higher load of challenge MDV DNA (threshold cycle [Ct] glyceraldehyde-3-phosphate dehydrogenase [GAPDH]/Ct glycoprotein B [gB] ratios of 1.0, 1.04, and 1.05 at 3, 5, and 15 wpc, respectively) than those that did not develop MD (Ct GAPDH/Ct gB ratios of 0.7, 0.69, and 0.46 at 3, 5, and 15 wpc, respectively). However, load of HVT DNA in blood was not correlated with the development of tumors (Ct GAPDH/Ct HVT ratios from 0.04 to 0.10 in both groups). Vaccinated groups with >75% protection had statistically significant less challenge DNA virus (Ct GAPDH/Ct gB ratios of 0.76, 0.70, and 0.45 at 3, 5, and 15 wpc, respectively) than less protected groups (Ct GAPDH/Ct gB ratios of 0.92, 0.97, and 0.85 at 3, 5, and 15 wpc, respectively). No differences in the load of HVT DNA could be found between protected and nonprotected groups at any time point of the study (Ct GAPDH/Ct HVT from 0.05 to 0.09 in both groups). Our

  18. Language as a biological entity

    Institute of Scientific and Technical Information of China (English)

    张舒音

    2010-01-01

    @@ Nowadays, the metaphor of "languageas abiological entity"claimed by some linguists being used widely has become a hot issue. Language and biological entity indeed share a lot of similarities,specifically,the life cycle of languages and the process of the language evolution and the spread of languages.

  19. Pathological Mobilization and Activities of Dendritic Cells in Tumor-Bearing Hosts: Challenges and Opportunities for Immunotherapy of Cancer

    Science.gov (United States)

    Tesone, Amelia J.; Svoronos, Nikolaos; Allegrezza, Michael J.; Conejo-Garcia, Jose R.

    2013-01-01

    A common characteristic of solid tumors is the pathological recruitment of immunosuppressive myeloid cells, which in certain tumors includes dendritic cells (DCs). DCs are of particular interest in the field of cancer immunotherapy because they induce potent and highly specific anti-tumor immune responses, particularly in the early phase of tumorigenesis. However, as tumors progress, these cells can be transformed into regulatory cells that contribute to an immunosuppressive microenvironment favoring tumor growth. Therefore, controlling DC phenotype has the potential to elicit effective anti-tumor responses while simultaneously weakening the tumor’s ability to protect itself from immune attack. This review focuses on the dual nature of DCs in the tumor microenvironment, the regulation of DC phenotype, and the prospect of modifying DCs in situ as a novel immunotherapeutic approach. PMID:24339824

  20. Entity Ranking using Wikipedia as a Pivot

    NARCIS (Netherlands)

    Kaptein, R.; Serdyukov, P.; Vries, A.P. de; Kamps, J.

    2010-01-01

    In this paper we investigate the task of Entity Ranking on the Web. Searchers looking for entities are arguably better served by presenting a ranked list of entities directly, rather than a list of web pages with relevant but also potentially redundant information about these entities. Since entitie

  1. Congenital peribronchial myofibroblastic tumor: Case report and review of literature

    Directory of Open Access Journals (Sweden)

    Jolanta Jedrzkiewicz

    2015-04-01

    Full Text Available Congenital peribronchial myofibroblastic tumor (CPMT is a rare entity recognized in the WHO classification of pulmonary neoplasms. According to available literature, it is a benign tumor with a high mortality rate exceeding 50%. It is partially attributed to polyhydramnios, hydrops, prematurity, respiratory distress or adverse surgical outcomes due to intraoperative bleeding. Herein we present a case of congenital peribronchial myofibroblastic tumor in a premature male infant who was born at 31 weeks gestation due to polyhydramnios and premature rupture of membranes. Soon after birth, he required intubation due to worsening respiratory distress. Imaging demonstrated a large right chest mass causing mediastinal shift. Surgical intervention was attempted, which was challenging due to intraoperative bleeding and tumor retraction. The patient expired soon after the surgery. Hence, in this report we would like to share our experience with this difficult diagnosis and treatment of this rare tumor.

  2. Evaluation of Query Generators for Entity Search Engines

    CERN Document Server

    Endrullis, Stefan; Rahm, Erhard

    2010-01-01

    Dynamic web applications such as mashups need efficient access to web data that is only accessible via entity search engines (e.g. product or publication search engines). However, most current mashup systems and applications only support simple keyword searches for retrieving data from search engines. We propose the use of more powerful search strategies building on so-called query generators. For a given set of entities query generators are able to automatically determine a set of search queries to retrieve these entities from an entity search engine. We demonstrate the usefulness of query generators for on-demand web data integration and evaluate the effectiveness and efficiency of query generators for a challenging real-world integration scenario.

  3. [Cartilage tumors : Pathology and radiomorphology].

    Science.gov (United States)

    Uhl, M; Herget, G; Kurz, P

    2016-06-01

    Primary cartilage-forming tumors of the bone are frequent entities in the daily work of skeletal radiologists. This article describes the correlation of pathology and radiology in cartilage-forming skeletal tumors, in particular, enchondroma, osteochondroma, periosteal chondromas, chondroblastoma and various forms of chondrosarcoma. After reading, the radiologist should be able to deduce the different patterns of cartilage tumors on radiographs, CT, and MRI from the pathological aspects. Differentiation of enchondroma and chondrosarcoma is a frequent diagnostic challenge. Some imaging parameters, e. g., deep cortical scalloping (more than two thirds of the cortical thickness), cortical destruction, or a soft-tissue mass, are features of a sarcoma. Osteochondromas are bony protrusions with a continuous extension of bone marrow from the parent bone, the host cortical bone runs continuously from the osseous surface of the tumor into the shaft of the osteochondroma and the osteochondroma has a cartilage cap. Chondromyxoid fibromas are well-defined lytic and eccentric lesions of the metaphysis of the long bones, with nonspecific MRI findings. Chondroblastomas have a strong predilection for the epiphysis of long tubular bones and develop an intense perifocal bone marrow edema. Dedifferentiated chondrosarcomas are bimorphic lesions with a low-grade chondrogenic component and a high-grade noncartilaginous component. Most chondrogenic tumors have a predilection with regard to site and age at manifestation. PMID:27233920

  4. Tumor de células gigantes da extremidade distal do fêmur: um desafio de tratamento Giant cell tumor of femoral distal end: a challenge in treatment

    Directory of Open Access Journals (Sweden)

    Suraj Bajracharya

    2009-01-01

    Full Text Available Apresentamos aqui um caso de tumor de células gigantes na extremidade distal do fêmur direito tratado com ressecção da massa tumoral em bloco com remoção aguda da extremidade proximal e distal e fixado com hastes longas em K atravessando o joelho, do fêmur à tíbia. Após a consolidação / união completa das extremidades, foi feita a remoção da haste em K, seguida pela corticotomia juntamente com a osteogênese da distração com o auxílio do anel fixador de Ilizarov. O comprimento foi alcançado com este processo. O resultado final foi muito bom neste caso. Revisamos as opções de tratamento para tumor maligno de células gigantes na extremidade distal do fêmur e as dificuldades de tratá-lo.We present a case of malignant giant cell tumor of distal end of right femur treated with resection of the tumor mass en block with acute docking of proximal and distal end and fixed with long K-nail across knee from femur to tibia. After complete consolidation/ union of the ends, removal of K nail was done followed by corticotomy along with distraction osteogenesis with the help of Ilizarov ring fixator. The length was achieved with this process. The end result was very good in this case. We reviewed the treatment options for malignant giant cell tumor of femoral distal end and the challenges in its treatment.

  5. Colorectal cancer, one entity or three

    Institute of Scientific and Technical Information of China (English)

    Feng-ying LI; Mao-de LAI

    2009-01-01

    Understanding of the mechanism ofcolorectal carcinogenesis has been gaining momentum for some years on account of its high incidence and impact on the lives of individuals affected. Different genetic abnormalities have been found in colorectal cancers from different sites. For example, proximal colon cancer is usually related to the nucleotide instability pathway, as mi-crosatellite instability (MSI). However, distal colon cancer is usually associated with specific chromosomal instability (CIN). The development of cancer at the rectum, though similar to that at the colon, displays its own unique features. These differences might be partially attributed to different embryological development and physiological circumstances. Environmental factors such as diet and alcohol intake also differ in their role in the development of tumors in the three segments, proximal colon, distal colon, and rectum. "Proximal shift" of colon cancer has been known for some time, and survival rates of colorectal cancer are higher when rectal cancers are excluded, both of which emphasize the three different segments of colorectal cancer and their different proper-ties. Meanwhile, colonic and rectal cancers are distinctive therapeutic entities. The concept of three entities of colorectal cancer may be important in designing clinical trails or therapeutic strategies. However, the dispute about the inconsistency of data con-ceming the site-specific mechanism of colorectal carcinoma does exist, and more evidence about molecular events of carcino-genesis and targeted therapy needs to be collected to definitely confirm the conception.

  6. CONSIDERATIONS ON ENTITY'S RISK ANALYSIS

    Directory of Open Access Journals (Sweden)

    MIRELA MONEA

    2014-12-01

    Full Text Available In the present paper, because of the complexity of this topic, the purpose is to discuss the main aspects involved by risk analysis; starting with few conceptual approaches about risk and to outline the contributions about methods to assess different risks categories, especially methods to assess bankruptcy risk prediction (entity insolvency from economic literature. The methods used to estimate bankruptcy risk are based on the score function which helps to find if an entity is confronted with financial difficulties. The score functions are a diagnosis method elaborated relying on the discriminant analysis, allowing to assess and to predict the bankruptcy risk of the entity using a set of relevant financial ratios.

  7. Malignant struma ovarii: a rare oncologic entity

    International Nuclear Information System (INIS)

    Struma ovarii (SO) malignant is a rare ovarian teratoid tumor, consisting predominantly of thyroid tissue. It has low incidence and a few cases described by the literature. Usually appears in the 4th or 5th decade of life. Generally they are diagnosed after surgery, being the diagnostic reserved for the lesions on the ectopic thyroid tissue based on cellular atypia, mitotic activity, capsular invasion and metastases. Due to its rarity,it does not still have a consensus about the best therapeutical management and protocol of accompaniment for patients with this neoplastic entity. This article reports a case of a patient with malignant S O, reviewing the relevant aspects of the literature. (author)

  8. Named entity normalization in user generated content

    NARCIS (Netherlands)

    V. Jijkoun; M.A. Khalid; M. Marx; M. de Rijke

    2008-01-01

    Named entity recognition is important for semantically oriented retrieval tasks, such as question answering, entity retrieval, biomedical retrieval, trend detection, and event and entity tracking. In many of these tasks it is important to be able to accurately normalize the recognized entities, i.e.

  9. Programming Entity Framework Code First

    CERN Document Server

    Lerman, Julia

    2011-01-01

    Take advantage of the Code First data modeling approach in ADO.NET Entity Framework, and learn how to build and configure a model based on existing classes in your business domain. With this concise book, you'll work hands-on with examples to learn how Code First can create an in-memory model and database by default, and how you can exert more control over the model through further configuration. Code First provides an alternative to the database first and model first approaches to the Entity Data Model. Learn the benefits of defining your model with code, whether you're working with an exis

  10. Achievements and challenges of adoptive T cell therapy with tumor-infiltrating or blood-derived lymphocytes for metastatic melanoma

    DEFF Research Database (Denmark)

    Svane, Inge Marie; Verdegaal, Els M

    2014-01-01

    with durable complete tumor eradication. These remarkable results justify the need for a definitive phase III trial documenting the efficacy of this type of T cell-based Advanced Therapy Medicinal Product in order to pave the way for regulatory approval and implementation of TIL therapy as a new treatment......Adoptive cell therapy (ACT) based on autologous T cell derived either from tumor as tumor-infiltrating lymphocytes (TILs) or from peripheral blood is developing as a key area of future personalized cancer therapy. TIL-based ACT is defined as the infusion of T cells harvested from autologous fresh...... and interleukin-2 in addition to T cell infusion. To this end, adoptive T cell therapy using peripheral blood mononuclear cell-derived T cells could be a welcome alternative to circumvent these limitations and broaden up the applicability of ACT. Here, we discuss current initiatives in this focused research...

  11. Opportunities and Challenges Debating for the Right and the Wrong of Non-practicing Entities%危机抑或机遇:专利经营实体是非置辩

    Institute of Scientific and Technical Information of China (English)

    李晓秋

    2012-01-01

    专利经营实体的兴起及其商业模式引起了国内外的广泛关注,其法律定性一直颇具争议.如何定性,不仅决定着专利经营实体的未来,而且关系着一国专利政策的走向.本文解读了专利经营实体的内涵,澄清了它与“专利怪物”的区别,详细梳理了肯定和否定专利经营实体商业模式的争执面相,并对此进行了评析.结合对以高智公司和中彩联为代表的专利经营实体的介绍,作者提出了我国在专利战略推进过程中应有的观念维度.%In recent years, the rises and the business models of Non-practicing Entities ( NPES) have evoked strong attention in the world. However, the topic related to justifying NPES is very much controversial. The issue is not only possible to determine,the future of the NPES, but also to affect patent policies. This paper interprets the connotation of NPES, as well as clarifying the difference between NPES and Patent Troll. The study also gives some details of the serious controversy about NPES' business model, followed by a remark. Based on the introduction of Intellectual Venture and CTU-Tech, the author pointed out that it would be necessary to take a right stand and seek for good countermeasures for NPES during the process of Promoting Patent Strategy.

  12. The MOBI-Kids Study Protocol: Challenges in Assessing Childhood and Adolescent Exposure to Electromagnetic Fields from Wireless Telecommunication Technologies and Possible Association with Brain Tumor Risk

    Science.gov (United States)

    Sadetzki, Siegal; Langer, Chelsea Eastman; Bruchim, Revital; Kundi, Michael; Merletti, Franco; Vermeulen, Roel; Kromhout, Hans; Lee, Ae-Kyoung; Maslanyj, Myron; Sim, Malcolm R.; Taki, Masao; Wiart, Joe; Armstrong, Bruce; Milne, Elizabeth; Benke, Geza; Schattner, Rosa; Hutter, Hans-Peter; Woehrer, Adelheid; Krewski, Daniel; Mohipp, Charmaine; Momoli, Franco; Ritvo, Paul; Spinelli, John; Lacour, Brigitte; Delmas, Dominique; Remen, Thomas; Radon, Katja; Weinmann, Tobias; Klostermann, Swaantje; Heinrich, Sabine; Petridou, Eleni; Bouka, Evdoxia; Panagopoulou, Paraskevi; Dikshit, Rajesh; Nagrani, Rajini; Even-Nir, Hadas; Chetrit, Angela; Maule, Milena; Migliore, Enrica; Filippini, Graziella; Miligi, Lucia; Mattioli, Stefano; Yamaguchi, Naohito; Kojimahara, Noriko; Ha, Mina; Choi, Kyung-Hwa; Mannetje, Andrea ’t; Eng, Amanda; Woodward, Alistair; Carretero, Gema; Alguacil, Juan; Aragones, Nuria; Suare-Varela, Maria Morales; Goedhart, Geertje; Schouten-van Meeteren, A. Antoinette Y. N.; Reedijk, A. Ardine M. J.; Cardis, Elisabeth

    2014-01-01

    The rapid increase in mobile phone use in young people has generated concern about possible health effects of exposure to radiofrequency (RF) and extremely low frequency (ELF) electromagnetic fields (EMF). MOBI-Kids, a multinational case–control study, investigates the potential effects of childhood and adolescent exposure to EMF from mobile communications technologies on brain tumor risk in 14 countries. The study, which aims to include approximately 1,000 brain tumor cases aged 10–24 years and two individually matched controls for each case, follows a common protocol and builds upon the methodological experience of the INTERPHONE study. The design and conduct of a study on EMF exposure and brain tumor risk in young people in a large number of countries is complex and poses methodological challenges. This manuscript discusses the design of MOBI-Kids and describes the challenges and approaches chosen to address them, including: (1) the choice of controls operated for suspected appendicitis, to reduce potential selection bias related to low response rates among population controls; (2) investigating a young study population spanning a relatively wide age range; (3) conducting a large, multinational epidemiological study, while adhering to increasingly stricter ethics requirements; (4) investigating a rare and potentially fatal disease; and (5) assessing exposure to EMF from communication technologies. Our experience in thus far developing and implementing the study protocol indicates that MOBI-Kids is feasible and will generate results that will contribute to the understanding of potential brain tumor risks associated with use of mobile phones and other wireless communications technologies among young people. PMID:25295243

  13. The MOBI-Kids study protocol: challenges in assessing childhood and adolescent exposure to electromagnetic fields from wireless telecommunication technologies and possible association with brain tumor risk

    Directory of Open Access Journals (Sweden)

    Siegal eSadetzki

    2014-09-01

    Full Text Available The rapid increase in mobile phone use in young people has generated concern about possible health effects of exposure to radiofrequency (RF, extremely low frequency (ELF electromagnetic fields (EMF. MOBI-Kids, a multinational case-control study, investigates the potential effects of childhood and adolescent exposure to EMF from mobile communications technologies on brain tumor risk in 14 countries. The study, which aims to include approximately 1,000 brain tumor cases aged 10-24 years and two individually matched controls for each case, follows a common protocol and builds upon the methodological experience of the INTERPHONE study. The design and conduct of a study on EMF exposure and brain tumor risk in young people in a large number of countries is complex and poses methodological challenges. This manuscript discusses the design of MOBI-Kids and describes the challenges and approaches chosen to address them, including: 1 the choice of controls operated for suspected appendicitis, to reduce potential selection bias related to low response rates among population controls; 2 investigating a young study population spanning a relatively wide age-range. 3 conducting a large, multinational epidemiological study, while adhering to increasingly stricter ethics requirements; 4 investigating a rare and potentially fatal disease; and 5 assessing exposure to EMF from communication technologies. Our experience thus far developing and implementing the study protocol indicates that MOBI-Kids is feasible and will generate results that will contribute to the understanding of potential brain tumor risks associated with use of mobile phones and other wireless communications technologies among young people.

  14. The MOBI-Kids Study Protocol: Challenges in Assessing Childhood and Adolescent Exposure to Electromagnetic Fields from Wireless Telecommunication Technologies and Possible Association with Brain Tumor Risk.

    Science.gov (United States)

    Sadetzki, Siegal; Langer, Chelsea Eastman; Bruchim, Revital; Kundi, Michael; Merletti, Franco; Vermeulen, Roel; Kromhout, Hans; Lee, Ae-Kyoung; Maslanyj, Myron; Sim, Malcolm R; Taki, Masao; Wiart, Joe; Armstrong, Bruce; Milne, Elizabeth; Benke, Geza; Schattner, Rosa; Hutter, Hans-Peter; Woehrer, Adelheid; Krewski, Daniel; Mohipp, Charmaine; Momoli, Franco; Ritvo, Paul; Spinelli, John; Lacour, Brigitte; Delmas, Dominique; Remen, Thomas; Radon, Katja; Weinmann, Tobias; Klostermann, Swaantje; Heinrich, Sabine; Petridou, Eleni; Bouka, Evdoxia; Panagopoulou, Paraskevi; Dikshit, Rajesh; Nagrani, Rajini; Even-Nir, Hadas; Chetrit, Angela; Maule, Milena; Migliore, Enrica; Filippini, Graziella; Miligi, Lucia; Mattioli, Stefano; Yamaguchi, Naohito; Kojimahara, Noriko; Ha, Mina; Choi, Kyung-Hwa; Mannetje, Andrea 't; Eng, Amanda; Woodward, Alistair; Carretero, Gema; Alguacil, Juan; Aragones, Nuria; Suare-Varela, Maria Morales; Goedhart, Geertje; Schouten-van Meeteren, A Antoinette Y N; Reedijk, A Ardine M J; Cardis, Elisabeth

    2014-01-01

    The rapid increase in mobile phone use in young people has generated concern about possible health effects of exposure to radiofrequency (RF) and extremely low frequency (ELF) electromagnetic fields (EMF). MOBI-Kids, a multinational case-control study, investigates the potential effects of childhood and adolescent exposure to EMF from mobile communications technologies on brain tumor risk in 14 countries. The study, which aims to include approximately 1,000 brain tumor cases aged 10-24 years and two individually matched controls for each case, follows a common protocol and builds upon the methodological experience of the INTERPHONE study. The design and conduct of a study on EMF exposure and brain tumor risk in young people in a large number of countries is complex and poses methodological challenges. This manuscript discusses the design of MOBI-Kids and describes the challenges and approaches chosen to address them, including: (1) the choice of controls operated for suspected appendicitis, to reduce potential selection bias related to low response rates among population controls; (2) investigating a young study population spanning a relatively wide age range; (3) conducting a large, multinational epidemiological study, while adhering to increasingly stricter ethics requirements; (4) investigating a rare and potentially fatal disease; and (5) assessing exposure to EMF from communication technologies. Our experience in thus far developing and implementing the study protocol indicates that MOBI-Kids is feasible and will generate results that will contribute to the understanding of potential brain tumor risks associated with use of mobile phones and other wireless communications technologies among young people.

  15. HMM based Korean Named Entity Recognition

    Directory of Open Access Journals (Sweden)

    Yi-Gyu Hwang

    2003-02-01

    Full Text Available In this paper, we present a named entity recognition model for Korean Language. Named entity recognition is an essential and important process of Question Answering and Information Extraction system. This paper proposes a HMM based named entity recognition using compound word construction principles. In Korean, above 60% of NE (Named-Entity is a compound word. This compound word may be consisted of proper noun, common noun, or bound noun, etc. There is an intercontextual relationship among nouns which consists NE. NE and surrounding words of NE have a contextual relationship. For considering these relationships, we classified nouns into 4 word classes (Independent Entity, Constituent Entity, Adjacent Entity, Not an Entity. With this classification, our system gets contextual and lexical information by stochastic based machine leaning method from a NE labeled training data. Experimental result shows that this approach is better approach than rulebased in the Korean named-entity recognition.

  16. ADULT PANCREATOBLASTOMA: A RARE ENTITY

    OpenAIRE

    Ray; Venkatesh,; Ilayalvan; Sowmya,; Nidhya

    2014-01-01

    Pancreatoblastoma is a rare tumor of neuroendocrine origin affecting paediatric age group. It is an extremely rare neoplasm of adults. Patients with pancreatoblastoma present with complaints of abdominal pain and distension. Clinically diagnosis is usually of a retroperitoneal sarcoma or tumor of colon. This tumor is generally detected accidentally during laparotomy and diagnosis is confirmed by histopathology. The presence of squamoid corpuscles with a morular appearance ...

  17. [The "globulomaxillary cyst" a specific entity or a myth?].

    Science.gov (United States)

    Häring, Philipp; Filippi, Andreas; Bornstein, Michael M; Altermatt, Hans Jörg; Buser, Daniel; Lambrecht, J Thomas

    2006-01-01

    The following review investigates the term and concept of the globulomaxillary cyst as a correct clinico-pathological diagnosis to describe a so-called fissural cyst said to be caused by epithelial entrapment between the nasal and maxillary process. After analyzing the available literature it has to be concluded that neither from an embryologic nor from a clinical or pathohistological standpoint the term globulomaxillary cyst represents a real entity by itself. Therefore, globulomaxillary cysts have to be diagnosed alternatively after a thorough clinical, radiological and histological examination as other odontogenic cysts like dentigerous cysts or odontogenic keratocysts, odontogenic tumors like ameloblastoma, central giant cell tumors, solitary bone cysts, etc. PMID:16708524

  18. Mucinous nonneoplastic cyst of the pancreas: A truly novel pathological entity?

    Institute of Scientific and Technical Information of China (English)

    Brian K.P. Goh; Yu-Meng Tan; Puay-Hoon Tan; London L.P.J. Ooi

    2005-01-01

    Recently, a novel and distinct pancreatic cystic tumor termed "mucinous nonneoplastic" cyst was described in the literature.We report our experience with a 71-year-old female with a cystic tumor in the body of the pancreas demonstrating features suggestive of this diagnosis. We also review the literature regarding this "novel" pathological entity and discuss critically its existence and its differential diagnoses.

  19. TwitterNEED: a hybrid approach for named entity extraction and disambiguation for tweets

    NARCIS (Netherlands)

    Habib, Mena B.; Keulen, van Maurice

    2016-01-01

    Twitter is a rich source of continuously and instantly updated information. Shortness and informality of tweets are challenges for Natural Language Processing tasks. In this paper, we present TwitterNEED, a hybrid approach for Named Entity Extraction and Named Entity Disambiguation for tweets. We be

  20. Financial Statements in Particular Entity

    OpenAIRE

    Hořáková, Marie

    2011-01-01

    The thesis delivers suggestions to improve procedures in a financial statement from particular company according to an analysis of individual financial statement pieces and tests of a financial statement report. The first part of the literature search is devoted to an analysis of preparing pieces of the Financial Statement, necessary to carry out at the end of any accounting year to avoid distorting in accounting. After counting all issues, the accounting entity is to close all accounting...

  1. Entity Framework 41 Expert's Cookbook

    CERN Document Server

    Liles, Devlin

    2012-01-01

    This book takes a step-by-step problem solving approach that leads you through a problem and explains each step in detail to accomplish the goal. This books gives you concrete code examples as well as detailed information on the decisions involved. This book is for intermediate to advanced .NET developers who have used LINQ to SQL or Entity Framework in some form but want to have more control over the implementation.

  2. Collagenous Gastritis: A Rare Entity

    OpenAIRE

    Faten Limaiem; Sabeh Mzabi

    2015-01-01

    Collagenous gastritis is a rare entity of unknown etiology characterized histologically by the presence of a thick subepithelial collagen band associated with an inflammatory infiltrate of gastric mucosa. A 40-year-old male presented with a history of chronic intermittent abdominal pain for about 6 months. Physical examination was unremarkable, and biological tests were within normal range. The patient underwent esophagogastroduodenoscopy and colonoscopy which showed a nodular mucosa of the s...

  3. Updates on the diagnosis and treatment of intracranial nerve malignant peripheral nerve sheath tumors

    OpenAIRE

    L'Heureux-Lebeau B; Saliba I

    2013-01-01

    Bénédicte L'Heureux-Lebeau,1 Issam Saliba2 1University of Montreal, 2Department of Otolaryngology Head and Neck Surgery, Montreal University Hospital Center (CHUM), University of Montreal, Montreal, Quebec, Canada Background: Malignant peripheral nerve sheath tumors (MPNSTs) are rare entities and MPNSTs of intracranial nerves are even more sporadic. MPNSTs present diagnosis and treatment challenges since there are no defined diagnosis criteria and no established...

  4. Qualified Entity Certification Program for Medicare Data

    Data.gov (United States)

    U.S. Department of Health & Human Services — QECP welcomes any entities that would like to participate in, learn more about, or assess their capability to function as a qualified entity (QE) under section...

  5. Challenges in Identifying the Foot Motor Region in Patients with Brain Tumor on Routine MRI: Advantages of fMRI

    Science.gov (United States)

    Fisicaro, R.A.; Jiao, R.X.; Stathopoulos, C.; Brennan, N.M. Petrovich; Peck, K.K.; Holodny, A.I.

    2016-01-01

    BACKGROUND AND PURPOSE Accurate localization of the foot/leg motor homunculus is essential because iatrogenic damage can render a patient wheelchair- or bed-bound. We hypothesized the following: 1) Readers would identify the foot motor homunculus <100% of the time on routine MR imaging, 2) neuroradiologists would perform better than nonradiologists, and 3) those with fMRI experience would perform better than those without it. MATERIALSANDMETHODS Thirty-five attending-level raters (24 neuroradiologists, 11 nonradiologists) evaluated 14 brain tumors involving the frontoparietal convexity. Raters were asked to identify the location of the foot motor homunculus and determine whether the tumor involved the foot motor area and/or motor cortex by using anatomic MR imaging. Results were compared on the basis of prior fMRI experience and medical specialty by using Mann-Whitney U test statistics. RESULTS No rater was 100% correct. Raters correctly identified whether the tumor was in the foot motor cortex 77% of the time. Raters with fMRI experience were significantly better than raters without experience at foot motor fMRI centroid predictions (13 ± 6 mm versus 20 ± 13 mm from the foot motor cortex center, P = 2 × 10−6) and arrow placement in the motor gyrus (67% versus 47%, P = 7 × 10−5). Neuroradiologists were significantly better than nonradiologists at foot motor fMRI centroid predictions (15 ± 8 mm versus 20 ± 14 mm, P = .005) and arrow placement in the motor gyrus (61% versus 46%, P = .008). CONCLUSIONS The inability of experienced readers to consistently identify the location of the foot motor homunculus on routine MR imaging argues for using fMRI in the preoperative setting. Experience with fMRI leads to improved accuracy in identifying anatomic structures, even on routine MR imaging. PMID:25882288

  6. Maxillary Osteomyelitis: A Rare Entity.

    Science.gov (United States)

    Habib, Ayaaz; Sivaji, Nagaraj; Ashraf, Tauseef

    2016-01-01

    Osteomyelitis of the maxilla is now a rare event with the advent of antibiotics. The two predominant causes are odontogenic infections and sinusitis. Immunocompromised states such as diabetes, HIV, and malnutrition increase the risk of osteomyelitis. It is important to recognize this early as it is a difficult entity to treat with potentially serious consequences. We report an unusual case of right sided maxillary osteomyelitis in a lady with poorly controlled diabetes in rural Lincolnshire. Biopsy of the right maxillary bone showed features of acute osteomyelitis. This responded well to a prolonged course of oral antibiotics. PMID:27648332

  7. Maxillary Osteomyelitis: A Rare Entity

    Directory of Open Access Journals (Sweden)

    Ayaaz Habib

    2016-01-01

    Full Text Available Osteomyelitis of the maxilla is now a rare event with the advent of antibiotics. The two predominant causes are odontogenic infections and sinusitis. Immunocompromised states such as diabetes, HIV, and malnutrition increase the risk of osteomyelitis. It is important to recognize this early as it is a difficult entity to treat with potentially serious consequences. We report an unusual case of right sided maxillary osteomyelitis in a lady with poorly controlled diabetes in rural Lincolnshire. Biopsy of the right maxillary bone showed features of acute osteomyelitis. This responded well to a prolonged course of oral antibiotics.

  8. 22 CFR 96.5 - Requirement that accrediting entity be a nonprofit or public entity.

    Science.gov (United States)

    2010-04-01

    ... nonprofit or public entity. An accrediting entity must qualify as either: (a) An organization described in... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Requirement that accrediting entity be a nonprofit or public entity. 96.5 Section 96.5 Foreign Relations DEPARTMENT OF STATE LEGAL AND...

  9. LEGAL ENTITIES IN ROMANIAN PRIVATE INTERNATIONAL LAW

    Directory of Open Access Journals (Sweden)

    Berlingher Remus Daniel

    2013-12-01

    Full Text Available Legal entities play an increasing role in international economic relations, as well as in political, cultural, social or human relations. Any legal entity is subject to the law of a certain country, as it can only exist or function on the basis of legal provisions. In this sense, the paper analyses the law applicable to the organic statute of a legal entity, the importance and criteria underlying the establishment of a legal entity’s nationality, the recognition of foreign legal entities in Romania, as well as the rights and obligations of foreign legal entities residing in our country.

  10. Collagenous Gastritis: A Rare Entity

    Directory of Open Access Journals (Sweden)

    Faten Limaiem

    2015-06-01

    Full Text Available Collagenous gastritis is a rare entity of unknown etiology characterized histologically by the presence of a thick subepithelial collagen band associated with an inflammatory infiltrate of gastric mucosa. A 40-year-old male presented with a history of chronic intermittent abdominal pain for about 6 months. Physical examination was unremarkable, and biological tests were within normal range. The patient underwent esophagogastroduodenoscopy and colonoscopy which showed a nodular mucosa of the stomach. Biopsies of the duodenum and colon were unremarkable. However, biopsies of the gastric fundus revealed a mild chronic gastritis characterized by lymphocytic and plasma cell infiltration of deep mucosa, without lymphoid follicle formation or active inflammation. No microorganisms were identified on routine hematoxylin and eosin or Giemsa-stained sections. Subepithelial collagen in the gastric biopsies was thickened and showed entrapped capillaries. Subepithelial collagen was highlighted by Masson's trichrome staining and was negative for amyloid by Congo Red. In the areas containing thickened collagen, there were no intraepithelial lymphocytes. The final pathological diagnosis was collagenous gastritis. Collagenous gastritis is an extremely rare disease, but it is important to recognize its characteristic endoscopic and pathologic findings to make a correct diagnosis. Specific therapy for this rare entity has not yet been established. [J Interdiscipl Histopathol 2015; 3(2.000: 68-70

  11. Extradigital Glomus Tumor of Thigh

    Directory of Open Access Journals (Sweden)

    Kemal Beksaç

    2015-01-01

    Full Text Available Glomus tumors are benign neoplasms that arise from neuromyoarterial glomus bodies. They represent around 1–5% of all soft-tissue tumors. High temperature, sensitivity, and pain and localized tenderness are the classical triad of symptoms. Most glomus tumors represent in the subungual area of digits. Extradigital glomus tumors are a very rare entity. There are rare cases of these tumors reported to be in shoulder, elbow, knee, wrist, even stomach, colon, and larynx. We are reporting a case of a glomus tumor on thigh and discuss the histological and immunohistochemical features.

  12. [A little known entity: aggressive fibromatosis].

    Science.gov (United States)

    Marqúes Gubern, A; Pérez Payarols, J; Sánchez de Toledo, J; Martínez Ibáñez, V; Moraga, F; de Torres Ramírez, I M

    1991-01-01

    Aggressive fibromatosis is an unfrequent and little known entity, which in spite of being a histologically benign tumoration with scarce mitosis and without metastasis at distance, frequently presents with a high degree of local malignancy that can cause serious functional and aesthetical disturbance for the patient and even lead to death if infiltration of vital organs is presented, above all in cases of abdominal or maxillo-facial mass localization. The authors present their experience with 17 cases of aggressive fibromatosis observed in our centre: four of abdominal localization, six in extremities, five in the maxillo-facial mass, one in the torax and one in the lumbo-sacral region. Histological diagnosis, either by puncture or biopsy, is complemented by studies of extension of the tumour based on ecography and TAC. All cases were treated according to the classical criteria of ample resection of the lesion, always when practicable, except in one infant case and in the torax, in which only a biopsy was effected. Of the 15 cases resected, nine cases had local relapses, six of which remained free of disease with a second operation, another two required a third operation and the remaining case needed five interventions. In six children chemotherapy was applied with vincristina, cyclophosphamide and adriamicina. A follow up was carried out in 14 patients, one of which died and the remaining 13 are free of disease. In spite of the fact that progestagene receptors were not evidenced in two of our cases, one presented complete remission of the tumor after treatment with medroxyprogesterone. In this case the coincidence of Gardner's syndrome arises in the family history.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2043434

  13. [Schizoaffective disorder: An arguable diagnostic entity].

    Science.gov (United States)

    Garyfallos, G D

    2008-07-01

    Seventy-five years ago, J. Kasanin introduced the term "schizoaffective disorder" to refer to a disorder with symptoms of both schizophrenia and affective disorders. Since then, schizoaffective disorder has raised a considerable amount of discussion about its definition and position as a variant of schizophrenia, a variant of mood disorder or as an entity in between. This ambiguity is reflected on the definition of diagnostic criteria of the disorder in the taxonomic systems, which are practically too complex. Furthermore, there are essential differences between DSM-IV and ICD-10 regarding schizoaffective definition. Finally, the disorder has a very low inter-rater reliability and a very low longitudinal diagnostic stability. All the above have even led to proposals of elimination of schizoaffective disorder as a separate diagnostic entity. The prevalence of the disorder varies between 0.3% and 0.8%. Schizoaf fective disorder is more common in women than in men, a dif ference that is mostly attributed to increased incidence among women of the depressive type. The bipolar type of the disorder is more often found in young adults, whereas the depressive type is commoner in older adults. With regards to other variables such as educational level, marital status, prognosis, occupational level and social adjustment, schizoaffective disorder has more favourable characteristics than schizophrenia and less favourable than mood disorders. Age at onset is earlier than mood disorders and later than schizophrenia. The above epidemiologic and clinical data, as well as data from family, twin, genetic and neuroimaging studies, indicate that schizoaffective disorder can be best viewed as a mid-point on a continuum between schizophrenia and mood disorders and represents the most prominent paradigm challenging the so-called "Kraepelinian dichotomy" of major psychiatric disorders. Though schizoaffective disorder is a nosological nuisance, it is also a clinical reality and it is not

  14. Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK.

    Directory of Open Access Journals (Sweden)

    Natalia Ronkina

    Full Text Available MK5 (MAPK-activated protein kinase 5 or PRAK (p38-regulated and -activated kinase are alternative names for a serine/threonine protein kinase downstream to ERK3/4 and p38 MAPK. A previous gene targeting approach for MK5/PRAK (termed here MK5/PRAK-Δex8 revealed a seemingly tumor-suppressive role of MK5/PRAK in DMBA-induced one step skin carcinogenesis and Ras-induced transformation. Here we demonstrate that an alternative targeting strategy of MK5/PRAK (termed MK5/PRAK-Δex6 increased neither tumor incidence in the one step skin carcinogenesis model, nor Ras-induced transformation in primary cells. Interestingly, due to the targeting strategies and exon skipping both knockouts do not completely abolish the generation of MK5/PRAK protein, but express MK5/PRAK deletion mutants with different biochemical properties depending on the exon targeted: Targeting of exon 6 leads to expression of an unstable cytoplasmic catalytically inactive MK5/PRAK-Δex6 mutant while targeting of exon 8 results in a more stable nuclear MK5/PRAK-Δex8 mutant with residual catalytic activity. The different properties of the MK5/PRAK deletion mutants could be responsible for the observed discrepancy between the knockout strains and challenge the role of MK5/PRAK in p53-dependent tumor suppression. Further MK5/PRAK knockout and knock-in mouse strains will be necessary to assign a physiological function to MK5/PRAK in this model organism.

  15. The challenges of treating paraganglioma patients with {sup 177}Lu-DOTATATE PRRT: Catecholamine crises, tumor lysis syndrome and the need for modification of treatment protocols

    Energy Technology Data Exchange (ETDEWEB)

    Makis, William; Mccann, Karey; Mcewan, Alexander J. B. [Dept. of Diagnostic Imaging, Cross Cancer Institute, Alberta (China)

    2015-09-15

    A high percentage of paragangliomas express somatostatin receptors that can be utilized for targeted radioisotope therapy. The aim of this study was to describe and discuss the challenges of treating these tumors with {sup 177}Lu-[DOTA0,Tyr3]octreotate (DOTATATE) radioisotope therapy using established protocols. Three paraganglioma patients were treated with 4–5 cycles of {sup 177}Lu-DOTATATE and were evaluated for side effects and response to therapy. Two of the three patients developed severe adverse reactions following their first {sup 177}Lu-DOTATATE treatment. One patient developed a catecholamine crisis and tumor lysis syndrome within hours of treatment, requiring intensive care unit (ICU) support, and another developed a catecholamine crisis 3 days after treatment, requiring hospitalization. The treatment protocols at our institution were subsequently modified by increasing the radioisotope infusion time from 15 to 30 min, as recommended in the literature, to 2–4 h and by reducing the administered dose of {sup 177}Lu-DOTATATE. Subsequent {sup 177}Lu-DOTATATE treatments utilizing the modified protocols were well tolerated, and response to therapy was achieved in all three patients, resulting in significantly improved quality of life. {sup 177}Lu-DOTATATE is an exciting new therapeutic option in the management of paragangliomas; however, current treatment protocols described in the literature may need to be modified by lengthening the infusion time and/or lowering the initial treatment dose to prevent or reduce the severity of adverse reactions.

  16. Secure Environments for Collaboration among Ubiquitous Roaming Entities

    DEFF Research Database (Denmark)

    Jensen, Christian D.

    2002-01-01

    SECURE is a newly started IST project, which addresses secure collaboration among computational entities in emerging global computing systems. The properties of these systems introduce new security challenges that are not adequately addressed by existing security models and mechanisms. The scale...... and uncertainty of this global computing environment invalidates existing security models. Instead, new security models have to be developed along with new security mechanisms that control access to protected resources....

  17. Additive archaeology: an alternative framework for recontextualising archaeological entities

    OpenAIRE

    Reilly Paul

    2015-01-01

    Additive manufacturing poses a number of challenges to conventional understandings of materiality, including the so-called archaeological record. In particular, concepts such as real, virtual, and authentic are becoming increasingly unstable, as archaeological artefacts and assemblages can be digitalised, reiterated, extended and distributed through time and space as 3D printable entities. This paper argues that additive manufacturing represents a ‘grand disciplinary challenge’ to archaeologi...

  18. Towards Experience Management for Very Small Entities

    OpenAIRE

    Ribaud, Vincent; Saliou, Philippe; Laporte, Claude

    2011-01-01

    International audience The ISO/IEC 29110 standard: Lifecycle profiles for Very Small Entities, provides several Process Reference Models applicable to the vast majority of very small entities (defined by the ISO as "an entity (enterprise, organization, department or project) having up to 25 people") which do not develop critical software and share typical situational factors. An ISO/IEC 29110 pilot project has been established between the Software Engineering group at Brest University and ...

  19. Entity resolution in the web of data

    CERN Document Server

    Christophides, Vassilis; Stefanidis, Kostas

    2015-01-01

    In recent years, several knowledge bases have been built to enable large-scale knowledge sharing, but also an entity-centric Web search, mixing both structured data and text querying. These knowledge bases offer machine-readable descriptions of real-world entities, e.g., persons, places, published on the Web as Linked Data. However, due to the different information extraction tools and curation policies employed by knowledge bases, multiple, complementary and sometimes conflicting descriptions of the same real-world entities may be provided. Entity resolution aims to identify different descrip

  20. [Cirrhotic cardiomyopathy: a specific entity].

    Science.gov (United States)

    Brondex, A; Arlès, F; Lipovac, A-S; Richecoeur, M; Bronstein, J-A

    2012-04-01

    Cirrhosis is a frequent and severe condition, which is the late stage of numerous chronic liver diseases. It is associated with major hemodynamic alterations characteristic of hyperdynamic circulation and with a series of structural, functional, electrophysiological and biological heart abnormalities termed cirrhotic cardiomyopathy. The pathogenesis of this syndrome is multifactorial. It is usually clinically latent or mild, likely because the peripheral vasodilatation significantly reduces the left ventricle afterload. However, sudden changes of hemodynamic state (vascular filling, surgical or transjugular intrahepatic porto-systemic shunts, peritoneo-venous shunts and orthotopic liver transplantation) or myocardial contractility (introduction of beta-blocker therapy) can unmask its presence, and sometimes convert latent to overt heart failure. Cirrhotic cardiomyopathy may also contribute to the pathogenesis of hepatorenal syndrome. This entity has been described recently, and its diagnostic criteria are still under debate. To date, current management recommendations are empirical, nonspecific measures. Recognition of cirrhotic cardiomyopathy depends on a high level of awareness for the presence of this syndrome, particularly in patients with advanced cirrhosis who undergo significant surgical, pharmacological or physiological stresses. PMID:22115174

  1. Penoscrotal porokeratosis: A distinct entity

    Directory of Open Access Journals (Sweden)

    Rajiv Joshi

    2015-01-01

    Full Text Available A 26-year-old man presented with five months history of redness associated with itching and burning over the scrotum and shaft of the penis with a persistent rash on those sites. There had been no response to topical steroid and antifungal creams. Clinical examination revealed a large well-circumscribed erythematous plaque with a thready raised border with a tiny groove at its summit that involved almost two-thirds of the ventral part of the shaft of the penis. Ill-defined erythema with a granular surface was seen over the anterior scrotal skin. A 4 mm punch biopsy of the plaque on the penile shaft revealed multiple cornoid lamellae located adjacent to one another. The patient was treated with topical emollients. Follow up after four months revealed almost complete resolution of the plaque on the penile shaft. Penoscrotal porokeratosis appears to be a distinct entity in the family of porokeratotic diseases, described only in young males in their twenties with involvement of the penile shaft and anterior scrotum with severe burning and itching and histologically associated with multiple cornoid lamellae. It may represent an unusual epidermal porokeratotic reaction pattern and may be a self-resolving condition.

  2. 18 CFR 46.5 - Covered entities.

    Science.gov (United States)

    2010-04-01

    ... organization primarily engaged in the business of providing financial services or credit, a mutual savings bank... FOR PERSONS HOLDING INTERLOCKING POSITIONS § 46.5 Covered entities. Entities to which the general rule in § 46.4(b) applies are the following: (a) Any investment bank, bank holding company, foreign...

  3. Entity models for trigger-reaction documents

    NARCIS (Netherlands)

    M.A. Khalid; M. Marx; M.X. Makkes

    2008-01-01

    We define the notion of an entity model for a special kind of document popular on the web: an article followed by a list of reactions on that article, usually by many authors, usually inverse chronologically ordered. We call these documents trigger-reactions pairs. The entity model describes which n

  4. Entity search: building bridges between two worlds

    NARCIS (Netherlands)

    K. Balog; E. Meij; M. de Rijke

    2010-01-01

    We consider the task of entity search and examine to which extent state-of-art information retrieval (IR) and semantic web (SW) technologies are capable of answering information needs that focus on entities. We also explore the potential of combining IR with SW technologies to improve the end-to-end

  5. 31 CFR 800.211 - Entity.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 800.211 Section 800.211 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF INVESTMENT... separate legal entity) operated by any one of the foregoing as a business undertaking in a...

  6. Code-first development with Entity Framework

    CERN Document Server

    Barskiy, Sergey

    2015-01-01

    This book is intended for software developers with some prior experience with the Microsoft .NET framework who want to learn how to use Entity Framework. This book will get you up and running quickly, providing many examples that illustrate all the key concepts of Entity Framework.

  7. 46 CFR 403.110 - Accounting entities.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Accounting entities. 403.110 Section 403.110 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE UNIFORM ACCOUNTING SYSTEM General § 403.110 Accounting entities. Each Association shall be a separate...

  8. Dedifferentiated gastrointestinal stromal tumor arising de novo from the small intestine.

    Science.gov (United States)

    Choi, Jacqueline J; Sinada-Bottros, Laura; Maker, Ajay V; Weisenberg, Elliot

    2014-04-01

    Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract and usually display monotonous cytologic features and immunoactivity for CD117. Anaplastic GIST, with pleomorphic cells and loss of CD117, until recently have only been reported in patients with chronic imatinib mesylate treatment. Dedifferentiated GISTs arising de novo is a newly identified entity that may prove to be difficult to diagnose. We present the case of a 52-year-old female found to have a dedifferentiated GIST without prior imatinib mesylate therapy. This case is the first reported dedifferentiated GIST arising de novo from the small bowel, and at 30cm in greatest diameter, the largest reported to date. Additionally, we demonstrate for the first time the loss of DOG1 in the anaplastic component of the tumor. De novo dedifferentiated GIST is a rare and diagnostically challenging tumor that may be mischaracterized unless considered in the differential diagnosis. PMID:24484970

  9. The role of imaging for the surgeon in primary malignant bone tumors of the chest wall

    International Nuclear Information System (INIS)

    Primary malignant chest wall tumors are rare. The most frequent primary malignant tumor of the chest wall is chondrosarcoma, less common are primary bone tumors belonging to the Ewing Family Bone Tumors (EFBT), or even rarer are osteosarcomas. They represent a challenging clinical entities for surgeons as the treatment of choice for these neoplasms is surgical resection, excluding EFBT which are normally treated by a multidisciplinary approach. Positive margins after surgical procedure are the principal risk factor of local recurrence, therefore to perform adequate surgery a correct preoperative staging is mandatory. Imaging techniques are used for diagnosis, to determine anatomic site and extension, to perform a guided biopsy, for local and general staging, to evaluate chemotherapy response, to detect the presence of a recurrence. This article will focus on the role of imaging in guiding this often difficult surgery and the different technical possibilities adopted in our department to restore the mechanics of the thoracic cage after wide resections

  10. Comprehensive allelotype and genetic anaysis of 466 human nervous system tumors

    DEFF Research Database (Denmark)

    von Deimling, A; Fimmers, R; Schmidt, M C;

    2000-01-01

    Brain tumors pose a particular challenge to molecular oncology. Many different tumor entities develop in the nervous system and some of them appear to follow distinct pathogenic routes. Molecular genetic alterations have increasingly been reported in nervous system neoplasms. However......, a considerable number of affected genes remain to be identified. We present here a comprehensive allelotype analysis of 466 nervous system tumors based on loss of heterozygosity (LOH) studies with 129 microsatellite markers that span the genome. Specific alterations of the EGFR, CDK4, CDKN2A, TP53, DMBT1, NF2...... may provide a valuable framework for future studies to delineate molecular pathways in many types of human central nervous system tumors....

  11. Periocular xanthogranuloma: A forgotten entity?

    Directory of Open Access Journals (Sweden)

    Charalampos Papagoras

    2010-03-01

    Full Text Available Charalampos Papagoras1, George Kitsos2, Paraskevi V Voulgari1, Anastasia K Zikou3, Maria I Argyropoulou3, Aikaterini Zioga4, Alexandros A Drosos11Rheumatology Clinic, Department of Internal Medicine; 2Department of Ophthalmology; 3Department of Clinical Imaging and Radiology, 4Department of Pathology, Medical School, University of Ioannina, Ioannina, GreeceAbstract: Periocular xanthogranulomatous diseases are a rare group of disorders which are characterized by a predilection to affect the orbit and ocular adnexa and special histopathological features, in particular infiltrates comprising non-Langerhans-derived foamy histiocytes and Touton giant cells. The differential diagnosis is difficult and occasionally definite diagnosis cannot be established even after clinical and histopathological findings are taken together. We describe a case of a middle-aged man who presented with a 10-year history of voluminous eyelid swelling with concomitant late-onset atopic manifestations, namely bronchial asthma and allergic rhinitis with nasal polyps. After thorough clinical and laboratory investigation, including a biopsy of the eyelid, we classified the patient’s disease to a rare entity that has been relatively recently described: periocular xanthogranuloma associated with adult-onset asthma. In a review of the literature, no prospective trials concerning the treatment of this disease were found. The literature mainly contained case reports and case series in which corticosteroids and chemotherapy with alkylating agents have been reported to be beneficial. We treated our patient with a combination of oral corticosteroids and cyclophosphamide pulses and we observed substantial regression of the eyelid masses together with a normalization of systemic immunologic abnormalities.Keywords: periocular xanthogranuloma, adult-onset asthma, non-Langerhans histiocytoses, cyclophosphamide, methylprednisolone

  12. Named entity recognition in Slovene text

    Directory of Open Access Journals (Sweden)

    Tadej Štajner

    2013-12-01

    Full Text Available This paper presents an approach and an implementation of a named entity extractor for Slovene language, based on a machine learning approach. It is designed as a supervised algorithm based on Conditional Random Fields and is trained on the ssj500k annotated corpus of Slovene. The corpus, which is available under a Creative Commons CC-BY-NC-SA licence, is annotated with morphosyntactic tags, as well as named entities for people, locations, organisations, and miscellaneous names. The paper discusses the influence of morphosyntactic tags, lexicons and conjunctions of features of neighbouring words. An important contribution of this investigation is that morphosyntactic tags benefit named entity extraction. Using all the best-performing features the recognizer reaches a precision of 74% and a recall of 72%, having stronger performance on personal and geographical named entities, followed by organizations, but performs poorly on the miscellaneous entities, since this class is very diverse and consequently difficult to predict. A major contribution of the paper is also showing the benefits of splitting the class of miscellaneous entities into organizations and other entities, which in turn improves performance even on personal and organizational names. The software, developed in this research is freely available under the Apache 2.0 licence at http://ailab.ijs.si/~tadej/slner.zip, while development versions are available at https://github.com/tadejs/slner.

  13. Differential oxygen dynamics in two diverse Dunning prostate R3327 rat tumor sublines (MAT-Lu and HI) with respect to growth and respiratory challenge

    International Nuclear Information System (INIS)

    Purpose: Since hypoxia may influence tumor response to therapy and prognosis, we have compared oxygenation of tumors known to exhibit differential growth rate and tissue differentiation. Methods and Materials: Regional tumor oxygen tension was measured using 19F nuclear magnetic resonance echo planar imaging relaxometry of hexafluorobenzene, which provided dynamic maps with respect to respiratory intervention. Investigations used two Dunning prostate R3327 rat tumor sublines: the fast growing, highly metastatic MAT-Lu and the moderately well-differentiated, slower growing HI. Results: Both sublines showed significantly higher oxygen tension in smaller tumors (3) than in larger tumors (>3.5 cm3). Pooled data showed that MAT-Lu tumors exhibited greater hypoxia compared with the size-matched HI tumors (p2 for tumors of both sublines (p2, while those in the MAT-Lu tumors showed little response to respiratory intervention. Conclusions: These results concur with hypotheses that hypoxia is related to tumor growth rate and degree of differentiation. Under baseline conditions, the differences were subtle. However, response to respiratory intervention revealed highly significant differences, which, if held valid in the clinic, could have prognostic value

  14. 47 CFR 22.229 - Designated entities.

    Science.gov (United States)

    2010-10-01

    ... entrepreneur is an entity that, together with its controlling interests and affiliates, has average annual... entrepreneur, as defined in this section, or a consortium of entrepreneurs may use the bidding credit...

  15. 47 CFR 101.538 - Designated entities.

    Science.gov (United States)

    2010-10-01

    ... entrepreneur is an entity that, together with its controlling interests and affiliates, has average gross... entrepreneur, as defined in this section, or a consortium of entrepreneurs may use the bidding credit...

  16. Lack of a Common or Characteristic Cytogenetic Anomaly in Solitary Fibrous Tumor

    OpenAIRE

    Torabi, Alireza; Lele, Subodh M.; DiMaio, Dominick; Pinnt, Jeffrey C.; Hess, Michelle M.; Nelson, Marilu; Bridge, Julia A.

    2008-01-01

    Solitary fibrous tumor is a mesenchymal tumor that was initially described as a pleural-based lesion, but later was discovered in many other locations. The light microscopic appearance of solitary fibrous tumor may overlap with other diagnostic entities; however, consistent tumor cell CD34 immunoreactivity is useful in establishing the diagnosis. Limited data suggest that solitary fibrous tumors are karyotypically diverse; a common or characteristic anomaly has not yet emerged for this entity...

  17. Named Entity Recognition and Classification in Kannada Language

    Directory of Open Access Journals (Sweden)

    S Amarappa

    2013-01-01

    Full Text Available Named Entity Recognition and classification (NERC is an essential and challenging task in (NLP. Kannada is a highly inflectional and agglutinating language providing one of the richest and most challenging sets of linguistic and statistical features resulting in long and complex word forms, which is large in number. It is primarily a suffixing Language and inflected word starts with a root and may have several suffixes added to the right. It is also a Freeword order Language. Like other Indian languages, it is a resource poor language. Annotated corpora, name dictionaries, good morphological analyzers, Parts of Speech (POS taggers etc. are not yet available in the required measure and not many works are reported for this language. The work related to NERC in Kannada is not yet reported. In recent years, automatic named entity recognition and extraction systems have become one of the popular research areas. Building NERC for Kannada is challenging. It seeks to classify words which represent names in text into predefined categories like person name, location, organization, date, time etc. This paper deals with some attempts in this direction. This work starts with experiments in building Semi-Automated Statistical Machine learning NLP Models based on Noun Taggers. In this paper we have developed an algorithm based on supervised learning techniques that include Hidden Markov Model (HMM. Some sample results are reported.

  18. Constraint-satisfaction inference for entity recognition

    OpenAIRE

    Canisius, S.V.M.; Bosch, A.P.J. van den; Daelemans, W.M.P.

    2011-01-01

    One approach to QA answering is to match a question to candidate answers in a background corpus based on semantic overlap, possibly in combination with other levels of matching, such as lexical vector space similarity and syntactic similarity. While the computation of deep semantic similarity is as yet generally infeasible, semantic analysis in a specific domain is feasible, if the analysis is constrained to finding domain-specific entities and basic relations. Finding domain-specific entitie...

  19. IMPORTANCE OF INTERNAL AUDIT WITHIN AN ENTITY

    Directory of Open Access Journals (Sweden)

    Corina-Maria, DUCU

    2013-12-01

    Full Text Available The efficient operation of the entity in the current economic conditions involves the practical existence of an internal audit department which aims to plan and conduct various audit missions. The implementation of this function increases the efficiency to attract and use resources, as well as the effectiveness of the processes effectuated in order to improve performance. Moreover, today, the internal audit is a powerful tool to assist management in managing the operations within the entity.

  20. Shape Similarity Measures of Linear Entities

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The essential of feature matching technology lies in how to measure the similarity of spatial entities.Among all the possible similarity measures,the shape similarity measure is one of the most important measures because it is easy to collect the necessary parameters and it is also well matched with the human intuition.In this paper a new shape similarity measure of linear entities based on the differences of direction change along each line is presented and its effectiveness is illustrated.

  1. Management analysis of the selected business entity

    OpenAIRE

    Julie Zelená

    2007-01-01

    The fundamental practical contribution of my article is the completion of a management model of claim turnover whereof its implementation enables to enhance the productive force of the business entity and prevents the occurrence of a secondary insolvency of the enterprise. The secondary insolvency is forming an up-to-date problem of the current business entities and is often a reason for the occurrence of insolvency having its impacts in the field of commercial as well as criminal law. On the...

  2. [Eosinophllic meningitis, a very rare entity in Europe].

    Science.gov (United States)

    Tudisco, Jean-Blaise; Fumeaux, Christophe; Petignat, Pierre-Auguste

    2013-11-13

    Eosinophilic meningitis is a rare entity, which is a complication of an underlying disease. Its diagnosis and treatment is always a challenge for the hospital practitioner. The aim of this case report and review is to identify the most important aetiologies, and show the diagnostic and therapeutic modalities of Eosinophilic meningitis. The most frequent causes of Eosinophilic meningitis are parasitic and fungal infections. In Europe Eosinophilic meningitis is essentially seen in travellers returning from endemic areas for these agents. The treatment is directed against the underlying disease and can differ depending on the aetiology and severity of the clinical manifestations.

  3. [Tumor of the Parotid Gland].

    Science.gov (United States)

    Pötzl, Teresa; Iselin, Sabine; Husner, Alexander

    2016-05-11

    Salivary gland tumors are a rare, histologically heterogeneous group of tumors which constitute approximately 4–6 % of all head and neck neoplasms. In 2/3 of cases they are benign, especially in the parotid gland. We report about a rare tumor of the parotid gland presenting as an extraskeletal chondroma. Histologically there were multiple S 100 protein-positive nests of chondrocytes. The externally completed cytology suspected a pleomorphic adenoma, nevertheless, the final histopathological findings showed another tumor entity. PMID:27167480

  4. TRUS Findings of Prostate Tumor or Tumor Like Lesions

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hak Jong; Jang, Jung Min; Kim, Seung Hyup [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2006-03-15

    Tumors or tumor-like lesions in the prostate raise questions concerning their histogenesis and they may have prognoses dissimilar to those of prostatic adenocarcinoma. Several neoplasms involving the prostate have been described and characterized in recent years. In addition to adenocarcinoma, they include mucinous cyst adenocarcinoma, neuroendocrine cancer, lymphoma, spindle cell neoplasm, squamous cell carcinoma, transitional cell carcinoma, and benign prostatic hyperplasia (BPH) mimicking malignancy. In addition, infectious conditions such as tuberculosis and some stages of prostatic abscess can also mimic prostate tumors. Radiologic findings overlap and have limited roles in the diagnoses of these entities. However, knowledge of these variable tumors and tumor-like conditions is helpful when making accurate radiologic diagnoses, which have important clinical implications for treatment and prognosis. Transrectal ultrasound (TRUS) and available pathologic images of unusual tumors and tumor- like lesions are demonstrated in this article

  5. GASTROINTESTINAL STROMAL TUMOR (GIST

    Directory of Open Access Journals (Sweden)

    Luigi eTornillo

    2014-11-01

    Full Text Available Gastrointestinal stromal tumors are the most frequent mesenchymal tumors of the gastrointestinal tract. The discovery that these tumors, formerly thought of smooth muscle origin, are indeed better characterized by specific activating mutation in genes coding for the receptor tyrosine kinases CKIT and PDGFRA and that these mutations are strongly predictive for the response to targeted therapy with receptor tyrosine kinase inhibitors has made GISTs the typical example of the integration of basic molecular knowledge in the daily clinical activity. The information on the mutational status of these tumors is essential to predict (and subsequently to plan the therapy. As resistant cases are frequently wild-type, other possible oncogenic events, defining other entities, have been discovered (e.g. succinil dehydrogenase mutation/dysregulation, insuline growth factor expression, mutations in the RAS-RAF-MAPK pathway. The classification of disease must nowadays rely on the integration of the clinico-morphological characteristics with the molecular data.

  6. 我国骨盆恶性肿瘤外科治疗面临的难点和挑战%The challenges and difficult issues on surgical management of malignant pelvic tumors in China

    Institute of Scientific and Technical Information of China (English)

    牛晓辉; 徐万鹏

    2013-01-01

    The prognosis of malignant pelvic tumor is very poor although the incidence of them is not so high. In recent years, the surgical management in China has made great progress in many institutions. However, the challenges and difficult issues still exist. In this commentary, some important issues including anatomy and imaging of the pelvis, diagnosis dilemma, resection with adequate surgical margin, reconstruction, recurrence, complications, as well as national conditions are reviewed.

  7. Data Partitioning for Parallel Entity Matching

    CERN Document Server

    Kirsten, Toralf; Hartung, Michael; Groß, Anika; Köpcke, Hanna; Rahm, Erhard

    2010-01-01

    Entity matching is an important and difficult step for integrating web data. To reduce the typically high execution time for matching we investigate how we can perform entity matching in parallel on a distributed infrastructure. We propose different strategies to partition the input data and generate multiple match tasks that can be independently executed. One of our strategies supports both, blocking to reduce the search space for matching and parallel matching to improve efficiency. Special attention is given to the number and size of data partitions as they impact the overall communication overhead and memory requirements of individual match tasks. We have developed a service-based distributed infrastructure for the parallel execution of match workflows. We evaluate our approach in detail for different match strategies for matching real-world product data of different web shops. We also consider caching of in-put entities and affinity-based scheduling of match tasks.

  8. Improving Entity Resolution with Global Constraints

    CERN Document Server

    Gemmell, Jim; Chandra, Ashok K

    2011-01-01

    Some of the greatest advances in web search have come from leveraging socio-economic properties of online user behavior. Past advances include PageRank, anchor text, hubs-authorities, and TF-IDF. In this paper, we investigate another socio-economic property that, to our knowledge, has not yet been exploited: sites that create lists of entities, such as IMDB and Netflix, have an incentive to avoid gratuitous duplicates. We leverage this property to resolve entities across the different web sites, and find that we can obtain substantial improvements in resolution accuracy. This improvement in accuracy also translates into robustness, which often reduces the amount of training data that must be labeled for comparing entities across many sites. Furthermore, the technique provides robustness when resolving sites that have some duplicates, even without first removing these duplicates. We present algorithms with very strong precision and recall, and show that max weight matching, while appearing to be a natural choi...

  9. Prostaglandin release by cultured endometrial tissues after challenge with lipopolysaccharide and tumor necrosis factor α, in relation to the estrous cycle, treatment with medroxyprogesterone acetate, and pyometra.

    Science.gov (United States)

    Jursza-Piotrowska, Ewelina; Socha, Piotr; Skarzynski, Dariusz Jan; Siemieniuch, Marta Jolanta

    2016-04-01

    To better understand the pathogenesis of endometrial changes in cats associated with administration of progestagen contraceptives and with pyometra, we examined local variability of the prostaglandin synthesis system after challenge with either tumor necrosis factor α (TNF-α) or lipopolysaccharide (LPS) in organ cultures of endometrial tissues derived from cyclic cats, cats treated with medroxyprogesterone acetate (MPA), or cats with pyometra, as well as in cultured endometrial epithelial and stromal cells. In addition, spontaneous prostaglandin secretion was compared in endometria from different experimental groups. Data gathered in the present study show that the concentration of PGE2 in supernatants was increased only in endometrial organ cultures from cats with pyometra (P < 0.001) compared with other groups. This was also true for PGF2α in pyometra, compared with cats treated either short- or long-term with MPA and cats during late diestrus (P < 0.001), anestrus (P < 0.01), and estrus and middiestrus (P < 0.05). Treatment with LPS and TNF-α combined stimulated PGE2 secretion in all groups compared with the control (P < 0.001 for endometria of cats during anestrus or middiestrus, cats treated short-term with MPA, and those with pyometra; P < 0.01 for endometria of cats treated long-term with MPA; and P < 0.05 for the endometria of cats during estrus and late diestrus). The combined treatment with LPS and TNF-α increased PGF2α secretion in the endometria of cats treated short-term with MPA (P < 0.001), during anestrus and pyometra (P < 0.01 for both), and estrus and middiestrus (P < 0.05 for both), compared with the control. Spontaneous secretion of prostaglandins was several times greater in the endometria of queens with pyometra, compared with other groups, which may further regulate the local inflammatory response. Data gathered from endometrial cell culture and endometrial organ culture lead to the conclusion that disturbances in prostaglandin release

  10. Awareness of Entities, Activities and Contexts in Ambient Systems

    DEFF Research Database (Denmark)

    Kristensen, Bent Bruun

    2013-01-01

    Ambient systems are modeled by entities, activities and contexts, where entities exist in contexts and engage in activities. A context supports a dynamic collection of entities by services and offers awareness information about the entities. Activities also exist in contexts and model ongoing...

  11. Ranking Entities in Networks via Lefschetz Duality

    DEFF Research Database (Denmark)

    Aabrandt, Andreas; Hansen, Vagn Lundsgaard; Poulsen, Bjarne;

    2014-01-01

    then be ranked according to how essential their positions are in the network by considering the effect of their respective absences. Defining a ranking of a network which takes the individual position of each entity into account has the purpose of assigning different roles to the entities, e.g. agents......In the theory of communication it is essential that agents are able to exchange information. This fact is closely related to the study of connected spaces in topology. A communication network may be modelled as a topological space such that agents can communicate if and only if they belong...

  12. Entity Authentication:Analysis using Structured Intuition

    DEFF Research Database (Denmark)

    Ahmed, Naveed; Jensen, Christian D.

    2010-01-01

    In this paper, we propose a new method for the analysis that uses intuition of the analyst in a structured way. First we define entity authentication in terms of fine level authentication goals (FLAGs). Then we use some relevant structures in protocol narrations and use them to justify FLAGs for...

  13. Stump appendicitis: A rare clinical entity

    Directory of Open Access Journals (Sweden)

    Abhinav Kumar

    2013-01-01

    Full Text Available Stump appendicitis is one of the rare delayed complications after appendectomy with reported incidence of 1 in 50,000 cases. Stump appendicitis can present as a diagnostic dilemma if the treating clinician is unfamiliar with this rare clinical entity. We report an 18-year-old patient with Stump appendicitis, who underwent completion appendectomy laparoscopically.

  14. 77 FR 28250 - Entity List Additions; Corrections

    Science.gov (United States)

    2012-05-14

    ... General Trading, Office No. 205, Platinum Business Center, Baghdad Street, Al-Nahda 2, Al-Qusais, Dubai, U... Foreign Policy Interests of the United States'' in the Federal Register (77 FR 23114). This amendment... Persons to the Entity List'' in the Federal Register (77 FR 25055). This amendment corrects the...

  15. 13 CFR 130.200 - Eligible entities.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Eligible entities. 130.200 Section 130.200 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS DEVELOPMENT... or university; (3) A college or school of business, engineering, commerce or agriculture; (4)...

  16. 77 FR 56571 - Unincorporated Business Entities

    Science.gov (United States)

    2012-09-13

    ... Institutions, dated October 14, 2010, and published in the Federal Register at 75 FR 64728 on October 20, 2010... 12 CFR Parts 604, 611, 612, 619, 620, 621, 622, 623, and 630 RIN 3052-AC65 Unincorporated Business...) institutions' use of unincorporated business entities (UBEs) organized under State law for certain...

  17. 31 CFR 800.212 - Foreign entity.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Foreign entity. 800.212 Section 800.212 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... business is outside the United States or its equity securities are primarily traded on one or more...

  18. 31 CFR 598.303 - Entity.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 598.303 Section 598.303 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS..., organization, network, group, or subgroup, or any form of business collaboration....

  19. 47 CFR 27.1218 - Designated entities.

    Science.gov (United States)

    2010-10-01

    ... entrepreneur is an entity that, together with all attributed parties, has average gross revenues that are not... winning bid on any of the licenses in this subpart. (3) A winning bidder that qualifies as an entrepreneur, as defined in this section, or a consortium of entrepreneurs, may use a bidding credit of 15...

  20. 47 CFR 101.1429 - Designated entities.

    Science.gov (United States)

    2010-10-01

    ... for the preceding three years. (3) An entrepreneur is an entity that, together with its controlling... this chapter. A winning bidder that qualifies as an entrepreneur, as defined in this section, or a consortium of entrepreneurs may use the bidding credit specified in § 1.2110(f)(2)(iii) of this chapter....

  1. 47 CFR 27.702 - Designated entities.

    Science.gov (United States)

    2010-10-01

    ...) Eligibility for small business provisions. (1) An entrepreneur is an entity that, together with its... credits. A winning bidder that qualifies as an entrepreneur, as defined in this section, or a consortium of entrepreneurs may use the bidding credit specified in § 1.2110(f)(2)(i) of this chapter. A...

  2. A Tumor-Like Lesion Mimicking Mucinous (Colloid Carcinoma in Heterotopic Pancreas of the Prepyloric Antrum: A Formidable Challenge for Frozen Examination

    Directory of Open Access Journals (Sweden)

    Zafer Teke

    2010-05-01

    Full Text Available Context Heterotopic pancreas is defined as the presence of pancreatic tissue, outside its usual location, which lacks anatomical and vascular continuity with the pancreas proper. Despite the development of modern diagnostic procedures, it is still difficult to differentiate heterotopic pancreas from benign or malignant tumors and other tumor-like lesions. Frozen examination of mucinous lesions arising from heterotopic pancreas may represent a diagnostic problem. A decision may be very difficult and it is sometimes impossible to decide on the basis of the frozen sections whether a lesion is benign or malignant. Case report We report a tumor-like lesion mimicking a mucinous (colloid carcinoma arising in heterotopic pancreatic tissue in the prepyloric antrum of a 56-year-old woman which was found incidentally during an elective laparoscopic cholecystectomy for cholelithiasis. The tumor was treated by wedge resection and, in the frozen section examination, there were pancreatic ducts in the proper muscle layer, pancreatic acini with islets of Langerhans under the serosal surface and mucinous lakes close to the heterotopic pancreatic tissue and to a peripheral nerve. Conclusion The significance of this unusual lesion is its potential confusion with mucinous (colloid carcinoma or other mucous tumors. Such confusion is more likely to occur if the tissue sample is selective or limited, and the presence of pancreatic tissue cannot be verified. Therefore, we believe that a choice of local excision, wedge resection or more extensive eradication be determined only after intraoperative, pathological confirmation of the complete and accurate diagnosis.

  3. Collision tumor of the thyroid: follicular variant of papillary carcinoma and squamous carcinoma

    Directory of Open Access Journals (Sweden)

    Kane Subhadra V

    2006-09-01

    Full Text Available Abstract Background Collision tumors of the thyroid gland are a rare entity. We present a case of a follicular variant of papillary carcinoma and squamous carcinoma in the thyroid. To the best of our knowledge, this is the first documentation of a collision tumor with a papillary carcinoma and a squamous carcinoma within the thyroid gland. The clinicopathological features and immunohistochemical profile are reported. The theories of origin, epidemiology and management are discussed with a literature review. Case presentation A 65 year old woman presented with a large thyroid swelling of 10 years duration and with swellings on the back and scalp which were diagnosed to be a follicular variant of papillary thyroid carcinoma with metastasis. Clinical examination, radiology and endoscopy ruled out any other abnormality of the upper aerodigestive tract. The patient was treated surgically with a total thyroidectomy with central compartment clearance and bilateral selective neck dissections. The histopathology revealed a collision tumor with components of both a follicular variant of papillary carcinoma and a squamous carcinoma. Immunohistochemical analysis confirmed the independent origin of these two primary tumors. Adjuvant radio iodine therapy directed toward the follicular derived component of the thyroid tumor and external beam radiotherapy for the squamous component was planned. Conclusion Collision tumors of the thyroid gland pose a diagnostic as well as therapeutic challenge. Metastasis from distant organs and contiguous primary tumors should be excluded. The origins of squamous cancer in the thyroid gland must be established to support the true evolution of a collision tumor and to plan treatment. Treatment for collision tumors depends upon the combination of primary tumors involved and each component of the combination should be treated like an independent primary. The reporting of similar cases with longer follow-up will help define the

  4. Bone tumor

    Science.gov (United States)

    Tumor - bone; Bone cancer; Primary bone tumor; Secondary bone tumor ... The cause of bone tumors is unknown. They often occur in areas of the bone that grow rapidly. Possible causes include: Genetic defects ...

  5. Pre-Analytical Considerations for Successful Next-Generation Sequencing (NGS: Challenges and Opportunities for Formalin-Fixed and Paraffin-Embedded Tumor Tissue (FFPE Samples

    Directory of Open Access Journals (Sweden)

    Gladys Arreaza

    2016-09-01

    Full Text Available In cancer drug discovery, it is important to investigate the genetic determinants of response or resistance to cancer therapy as well as factors that contribute to adverse events in the course of clinical trials. Despite the emergence of new technologies and the ability to measure more diverse analytes (e.g., circulating tumor cell (CTC, circulating tumor DNA (ctDNA, etc., tumor tissue is still the most common and reliable source for biomarker investigation. Because of its worldwide use and ability to preserve samples for many decades at ambient temperature, formalin-fixed, paraffin-embedded tumor tissue (FFPE is likely to be the preferred choice for tissue preservation in clinical practice for the foreseeable future. Multiple analyses are routinely performed on the same FFPE samples (such as Immunohistochemistry (IHC, in situ hybridization, RNAseq, DNAseq, TILseq, Methyl-Seq, etc.. Thus, specimen prioritization and optimization of the isolation of analytes is critical to ensure successful completion of each assay. FFPE is notorious for producing suboptimal DNA quality and low DNA yield. However, commercial vendors tend to request higher DNA sample mass than what is actually required for downstream assays, which restricts the breadth of biomarker work that can be performed. We evaluated multiple genomics service laboratories to assess the current state of NGS pre-analytical processing of FFPE. Significant differences in pre-analytical capabilities were observed. Key aspects are highlighted and recommendations are made to improve the current practice in translational research.

  6. Pre-Analytical Considerations for Successful Next-Generation Sequencing (NGS): Challenges and Opportunities for Formalin-Fixed and Paraffin-Embedded Tumor Tissue (FFPE) Samples

    Science.gov (United States)

    Arreaza, Gladys; Qiu, Ping; Pang, Ling; Albright, Andrew; Hong, Lewis Z.; Marton, Matthew J.; Levitan, Diane

    2016-01-01

    In cancer drug discovery, it is important to investigate the genetic determinants of response or resistance to cancer therapy as well as factors that contribute to adverse events in the course of clinical trials. Despite the emergence of new technologies and the ability to measure more diverse analytes (e.g., circulating tumor cell (CTC), circulating tumor DNA (ctDNA), etc.), tumor tissue is still the most common and reliable source for biomarker investigation. Because of its worldwide use and ability to preserve samples for many decades at ambient temperature, formalin-fixed, paraffin-embedded tumor tissue (FFPE) is likely to be the preferred choice for tissue preservation in clinical practice for the foreseeable future. Multiple analyses are routinely performed on the same FFPE samples (such as Immunohistochemistry (IHC), in situ hybridization, RNAseq, DNAseq, TILseq, Methyl-Seq, etc.). Thus, specimen prioritization and optimization of the isolation of analytes is critical to ensure successful completion of each assay. FFPE is notorious for producing suboptimal DNA quality and low DNA yield. However, commercial vendors tend to request higher DNA sample mass than what is actually required for downstream assays, which restricts the breadth of biomarker work that can be performed. We evaluated multiple genomics service laboratories to assess the current state of NGS pre-analytical processing of FFPE. Significant differences in pre-analytical capabilities were observed. Key aspects are highlighted and recommendations are made to improve the current practice in translational research. PMID:27657050

  7. Big Data Challenges

    Directory of Open Access Journals (Sweden)

    Alexandru Adrian TOLE

    2013-10-01

    Full Text Available The amount of data that is traveling across the internet today, not only that is large, but is complex as well. Companies, institutions, healthcare system etc., all of them use piles of data which are further used for creating reports in order to ensure continuity regarding the services that they have to offer. The process behind the results that these entities requests represents a challenge for software developers and companies that provide IT infrastructure. The challenge is how to manipulate an impressive volume of data that has to be securely delivered through the internet and reach its destination intact. This paper treats the challenges that Big Data creates.

  8. Cross domains Arabic named entity recognition system

    KAUST Repository

    Al-Ahmari, S. Saad

    2016-07-11

    Named Entity Recognition (NER) plays an important role in many Natural Language Processing (NLP) applications such as; Information Extraction (IE), Question Answering (QA), Text Clustering, Text Summarization and Word Sense Disambiguation. This paper presents the development and implementation of domain independent system to recognize three types of Arabic named entities. The system works based on a set of domain independent grammar-rules along with Arabic part of speech tagger in addition to gazetteers and lists of trigger words. The experimental results shown, that the system performed as good as other systems with better results in some cases of cross-domains corpora. © (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

  9. The Autonomy of Indigenous Territorial Entities

    OpenAIRE

    Samuel Baena

    2015-01-01

    The dynamics that emerge between western civilization and indigenous groups are not exempt from historical and cultural imbalances that deserve different legal treatment. The starting point to achieve some level of equality is, in general terms, territorial law, and in specific terms, the principle of autonomy supported and lead by indigenous territorial entities. However, theoretical constructs of anthropology and systemic hermeneutics of the 1991 Constitution, allow for the existence of an ...

  10. Improving Access to Archival Collections with Automated Entity Extraction

    Directory of Open Access Journals (Sweden)

    Kyle Banerjee

    2015-07-01

    Full Text Available The complexity and diversity of archival resources make constructing rich metadata records time consuming and expensive, which in turn limits access to these valuable materials. However, significant automation of the metadata creation process would dramatically reduce the cost of providing access points, improve access to individual resources, and establish connections between resources that would otherwise remain unknown. Using a case study at Oregon Health & Science University as a lens to examine the conceptual and technical challenges associated with automated extraction of access points, we discuss using publically accessible API’s to extract entities (i.e. people, places, concepts, etc. from digital and digitized objects. We describe why Linked Open Data is not well suited for a use case such as ours. We conclude with recommendations about how this method can be used in archives as well as for other library applications.

  11. A Visual Entity-Relationship Model for Constraint-Based University Timetabling

    CERN Document Server

    Abdelraouf, Islam; Gervet, Carmen

    2011-01-01

    University timetabling (UTT) is a complex problem due to its combinatorial nature but also the type of constraints involved. The holy grail of (constraint) programming: "the user states the problem the program solves it" remains a challenge since solution quality is tightly coupled with deriving "effective models", best handled by technology experts. In this paper, focusing on the field of university timetabling, we introduce a visual graphic communication tool that lets the user specify her problem in an abstract manner, using a visual entity-relationship model. The entities are nodes of mainly two types: resource nodes (lecturers, assistants, student groups) and events nodes (lectures, lab sessions, tutorials). The links between the nodes signify a desired relationship between them. The visual modeling abstraction focuses on the nature of the entities and their relationships and abstracts from an actual constraint model.

  12. Tracking topological entity changes in 3D collaborative modeling systems

    Institute of Scientific and Technical Information of China (English)

    ChengYuan; He Fazhi; HuangZhiyong; Cai Xiantao; and Zhang Dejun

    2012-01-01

    One of the key problems in collaborative geometric modeling systems is topological entity correspondence when topolog- ical structure of geometry models on collaborative sites changes, ha this article, we propose a solution for tracking topological entity alterations in 3D collaborative modeling environment. We firstly make a thorough analysis and detailed categorization on the altera- tion properties and causations for each type of topological entity, namely topological face and topological edge. Based on collabora- tive topological entity naming mechanism, a data structure called TEST (Topological Entity Structure Tree) is introduced to track the changing history and current state of each topological entity, to embody the relationship among topological entities. Rules and algo- rithms are presented for identification of topological entities referenced by operations for correct execution and model consistency. The algorithm has been verified within the prototype we have implemented with ACIS.

  13. Dysembryoplastic neuroepithelial tumor: A rare brain tumor not to be misdiagnosed

    OpenAIRE

    Sukheeja, Deepti; Mehta, Jayanti

    2016-01-01

    Dysembryoplastic neuroepithelial tumor (DNET) is a recently described, morphologically unique, and surgically curable low-grade brain tumor which is included in the latest WHO classification as neuronal and mixed neuronal-glial tumor. It is usually seen in children and young adults. The importance of this particular entity is that it is a surgically curable neuroepithelial neoplasm. When recognized, the need for adjuvant radiotherapy and chemotherapy is obviated. We hereby present a case repo...

  14. 17 CFR 202.8 - Small entity compliance guides.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Small entity compliance guides. 202.8 Section 202.8 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION INFORMAL AND OTHER PROCEDURES § 202.8 Small entity compliance guides. The following small entity compliance guides are available to the public from...

  15. 7 CFR 25.401 - Responsibility of lead managing entity.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Responsibility of lead managing entity. 25.401 Section... COMMUNITIES Post-Designation Requirements § 25.401 Responsibility of lead managing entity. (a) Financial. The lead managing entity will be responsible for strategic plan program activities and monitoring...

  16. 77 FR 60948 - Stress Testing of Regulated Entities

    Science.gov (United States)

    2012-10-05

    ... help it to assess capital adequacy under various scenarios at the regulated entities. Section 165(i)(2..., forward-looking information that will help them to assess capital adequacy at the regulated entities under... element in a regulated entity's overall capital planning and capital adequacy assessment. If a...

  17. Semi-solid tumor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration.

    Science.gov (United States)

    Haynes-Gimore, Nikesha; Banach, Maureen; Brown, Edward; Dawes, Ryan; Edholm, Eva-Stina; Kim, Minsoo; Robert, Jacques

    2015-12-15

    Tumors have the ability to grow as a self-sustaining entity within the body. This autonomy is in part accomplished by the tumor cells ability to induce the formation of new blood vessels (angiogenesis) and by controlling cell trafficking inside the tumor mass. These abilities greatly reduce the efficacy of many cancer therapies and pose challenges for the development of more effective cancer treatments. Hence, there is a need for animal models suitable for direct microscopy observation of blood vessel formation and cell trafficking, especially during early stages of tumor establishment. Here, we have developed a reliable and cost effective tumor model system in tadpoles of the amphibian Xenopus laevis. Tadpoles are ideally suited for direct microscopy observation because of their small size and transparency. Using the thymic lymphoid tumor line 15/0 derived from, and transplantable into, the X. laevis/gilli isogenic clone LG-15, we have adapted a system that consists in transplanting 15/0 tumor cells embedded into rat collagen under the dorsal skin of LG-15 tadpole recipients. This system recapitulates many facets of mammalian tumorigenesis and permits real time visualization of the active formation of the tumor microenvironment induced by 15/0 tumor cells including neovascularization, collagen rearrangements as well as infiltration of immune cells and melanophores. PMID:25601449

  18. Interobserver variability in the differential diagnosis of benign bone tumors and tumor-like lesions; Interobservervariabilitaet in der Differentialdiagnose gutartiger Knochentumoren und tumoraehnlicher Knochenlaesionen

    Energy Technology Data Exchange (ETDEWEB)

    Scheitza, P.; Hauschild, O.; Zwingmann, J.; Suedkamp, N.P. [University Medical Centre Freiburg (Germany). Dept. of Orthopaedics and Traumatology; Uhl, M. [St. Josefshospital Freiburg (Germany). Dept. of Diagnostic and Therapeutic Radiology; Bannasch, H. [University Medical Centre Freiburg (Germany). Dept. of Plastic and Hand Surgery; Kayser, C. [University Medical Centre Freiburg (Germany). Dept. of Pathology; Herget, G.W. [University Medical Centre Freiburg (Germany). Dept. of Orthopaedics and Traumatology/Comprehensive Cancer Centre Freiburg CCCF

    2016-05-15

    The interobserver-variability of radiological diagnosis of benign bone tumors (BBT) and tumor-like lesions (TLL) was examined in order to identify difficult-to-diagnose entities, to examine the frequency of advanced diagnostics and to describe the number of interdisciplinary tumor center diagnoses (IDT) in comparison with diagnoses upon referral (ED) and radiologists' diagnoses (RD). We retrospectively reviewed 413 patients with 272 BBT and 141 TLL, classified either histologically or through interdisciplinary consultation. Discrepancies between groups were analyzed and rates of additional imaging and biopsy to establish diagnosis were assessed. In BBT the number of identical radiological diagnoses was 56 (ED) and 81 % (RD) compared to the IDT, while in the latter additional imaging were obtained in 30 % cases. In 21 % (12 % to establish diagnosis) BBT were biopsied, the ED matching the histology 40 %, the RD 60 % and the IDT 76 % of the time. For TLL diagnosed through radiology, ED and RD matched IDT 31 % and 61 % of the time, with additional imaging being obtained in 21 % of cases (IDT). In 36 % (27 % to establish diagnosis) biopsy was performed, with histological diagnosis matching the IDT, RD and ED in 51, 27 and 20 %. Diagnostic challenges were apparent in enchondromas, non-ossifying fibromas (NOF), solitary (SBC) and aneurysmal bone cysts (ABC). Ganglia can be misinterpreted as a tumor. Establishing a definitive diagnosis for BBT and TLL can be challenging with the latter posing greater difficulties. An interdisciplinary approach involving radiologists, orthopedics and pathologists was found to improve diagnostic accuracy.

  19. Recognizing Named Entities in Turkish Tweets

    Directory of Open Access Journals (Sweden)

    Beyza Eken

    2015-01-01

    Full Text Available Named entity recognition (NER is one of the well-s tudied sub-branch of natural language processing (NLP. State of the art NER systems give highly accurate results in domain of formal texts. With the expansion of microblog sites and so cial media, this informal text domain has become a new trend in NLP studies. Recent works has shown, social media texts are hard to process and the performance of the current systems substantially decrease when switched to this domain. We give our experience in improving named e ntity recognition on informal social media texts for the case of tweets.

  20. Co-operative Entities: Specific Accounting Aspects

    Directory of Open Access Journals (Sweden)

    MIGUEL ÁNGEL ZUBIAURRE ARTOLA

    2004-12-01

    Full Text Available The accounting regulation of co-operative societies have been recently reinforced with the approval of the ORDER ECO/3614/2003. The objective of this rule is to adapt the content of the Plan General de Contabilidad to the characteristics of these entities. In this work, I study the economic and accounting consequences of the special characteristics of co-operative societies on concepts like the result, capital, reserves or own equity, among others. The work combines the content of the state regulatory scheme on cooperative with the applicable legislation in the Basque Autonomous Community, as well as the national and international accounting regulation.

  1. Anaplastic Ependymoma in a Child With Sickle Cell Anemia: A Case Report Highlighting Treatment Challenges for Young Children With Central Nervous System Tumors and Underlying Vasculopathy.

    Science.gov (United States)

    Crotty, Erin E; Meier, Emily R; Wells, Elizabeth M; Hwang, Eugene I; Packer, Roger J

    2016-03-01

    A 3-year-old boy with sickle cell anemia (SCA) presented with progressive daily emesis and was found to have an anaplastic ependymoma. Radiation therapy and chemotherapy are usually employed after subtotal resections of anaplastic ependymomas, although the benefits from chemotherapy are unclear. To mitigate the risks of adjuvant treatment in this patient at risk for SCA-associated vasculopathy, renal impairment, and other end-organ damage, proton beam irradiation without chemotherapy was chosen. Scheduled packed red blood cell transfusions were instituted to maintain sickle hemoglobin levels less than 30%. This case highlights treatment complexities for malignant brain tumors in patients predisposed to treatment-related adverse effects.

  2. Updates on abdominal desmoid tumors

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Desmoid tumor is a monoclonal, fibroblastic proliferation arising in musculoaponeurotic structures. This connective tissue hyperplasia infiltrates locally, recurs frequentiy after resection but does not metastasize. Abdominal desmoid occurs sporadically, in association with some familial syndromes and often represents a clinical dilemma for surgeons. The enigmatic biology and anatomical location of abdominal desmoids make treatment recommendations difficult. This distinct pathological entity is reviewed with a specific focus on aetiology and management.

  3. Basal cell adenoma of the parotid gland: Cytological diagnosis of an uncommon tumor.

    Science.gov (United States)

    Bhat, Amoolya; Rao, Madhuri; Geethamani, V; Shetty, Archana C

    2015-01-01

    Basal cell adenoma (BCA) is a rare benign epithelial tumor of the salivary gland, displaying monomorphic basaloid cells without a myxochondroid component, representing 1-3% of all salivary gland neoplasms seen predominantly in women over 50 years of age. It is uncommon in young adults. Cytodiagnosis of basaloid tumors chiefly basal cell adenoma of the salivary gland, is extremely challenging. The cytological differential diagnoses range from benign to malignant, neoplastic to non- neoplastic lesions. Histopathological examination is a must for definitive diagnosis, as these entities differ in prognosis and therapeutic aspects. We present a 22-years-old male with this uncommon diagnosis with a discussion on the role of cytological diagnosis. Fine needle aspiration cytology is a simple, minimally invasive method for the preoperative diagnosis of various types of neoplastic and non-neoplastic lesions. The knowledge of its pitfalls and limitations contributes to a more effective approach to treatment. PMID:26097318

  4. Basal cell adenoma of the parotid gland: Cytological diagnosis of an uncommon tumor

    Directory of Open Access Journals (Sweden)

    Amoolya Bhat

    2015-01-01

    Full Text Available Basal cell adenoma (BCA is a rare benign epithelial tumor of the salivary gland, displaying monomorphic basaloid cells without a myxochondroid component, representing 1-3% of all salivary gland neoplasms seen predominantly in women over 50 years of age. It is uncommon in young adults. Cytodiagnosis of basaloid tumors chiefly basal cell adenoma of the salivary gland, is extremely challenging. The cytological differential diagnoses range from benign to malignant, neoplastic to non- neoplastic lesions. Histopathological examination is a must for definitive diagnosis, as these entities differ in prognosis and therapeutic aspects. We present a 22-years-old male with this uncommon diagnosis with a discussion on the role of cytological diagnosis. Fine needle aspiration cytology is a simple, minimally invasive method for the preoperative diagnosis of various types of neoplastic and non-neoplastic lesions. The knowledge of its pitfalls and limitations contributes to a more effective approach to treatment.

  5. Bone tumors of the spine and sacral bone; Primaere Tumoren der Wirbelsaeule und des Sakrums

    Energy Technology Data Exchange (ETDEWEB)

    Freyschmidt, Juergen [Klinikum Bremen-Mitte gGmbH, Bremen (Germany). Beratungsstelle und Referenzzentrum fuer Osteoradiologie

    2010-12-15

    Bone tumors and tumorlike lesions of the spine are rare entities and may harbour diagnostic problems. In this article we discuss the epidemiology, topographic aspects, clinical and radiologic features as well as the diagnostic management of vertebral bone tumors. Entities that should be more familiar to the radiologist (i.e. osteoid osteoma, osteoblastoma, hemangioma, giant cell tumor, chordoma, aneurysmal bone cyst) are considered in more detail. (orig.)

  6. Named Entity Recognition Using Web Document Corpus

    CERN Document Server

    Karaa, Wahiba Ben Abdessalem

    2011-01-01

    This paper introduces a named entity recognition approach in textual corpus. This Named Entity (NE) can be a named: location, person, organization, date, time, etc., characterized by instances. A NE is found in texts accompanied by contexts: words that are left or right of the NE. The work mainly aims at identifying contexts inducing the NE's nature. As such, The occurrence of the word "President" in a text, means that this word or context may be followed by the name of a president as President "Obama". Likewise, a word preceded by the string "footballer" induces that this is the name of a footballer. NE recognition may be viewed as a classification method, where every word is assigned to a NE class, regarding the context. The aim of this study is then to identify and classify the contexts that are most relevant to recognize a NE, those which are frequently found with the NE. A learning approach using training corpus: web documents, constructed from learning examples is then suggested. Frequency representatio...

  7. Named Entity Recognition Using Web Document Corpus

    Directory of Open Access Journals (Sweden)

    Wahiba Ben Abdessalem Karaa

    2011-02-01

    Full Text Available This paper introduces a named entity recognition approach in textual corpus. This Named Entity (NE can be a named: location, person, organization, date, time, etc., characterized by instances. A NE isfound in texts accompanied by contexts: words that are left or right of the NE. The work mainly aims at identifying contexts inducing the NE’s nature. As such, The occurrence of the word "President" in atext, means that this word or context may be followed by the name of a president as President "Obama". Likewise, a word preceded by the string "footballer" induces that this is the name of afootballer. NE recognition may be viewed as a classification method, where every word is assigned to a NE class, regarding the context. The aim of this study is then to identify and classify the contexts that are most relevant to recognize aNE, those which are frequently found with the NE. A learning approach using training corpus: web documents, constructed from learning examples is then suggested. Frequency representations andmodified tf-idf representations are used to calculate the context weights associated to context frequency, learning example frequency, and document frequency in the corpus.

  8. Information space models for data integration, and entity resolution

    Science.gov (United States)

    Porter, Reid; Collins, Linn; Powell, James; Rivenburgh, Reid

    2012-06-01

    Geospatial information systems provide a unique frame of reference to bring together a large and diverse set of data from a variety of sources. However, automating this process remains a challenge since: 1) data (particularly from sensors) is error prone and ambiguous, 2) analysis and visualization tools typically expect clean (or exact) data, and 3) it is difficult to describe how different data types and modalities relate to each other. In this paper we describe a data integration approach that can help address some of these challenges. Specifically we propose a light weight ontology for an Information Space Model (ISM). The ISM is designed to support functionality that lies between data catalogues and domain ontologies. Similar to data catalogues, the ISM provides metadata for data discovery across multiple, heterogeneous (often legacy) data sources e.g. maps servers, satellite images, social networks, geospatial blogs. Similar to domain ontologies, the ISM describes the functional relationship between these systems with respect to entities relevant to an application e.g. venues, actors and activities. We suggest a minimal set of ISM objects, and attributes for describing data sources and sensors relevant to data integration. We present a number of statistical relational learning techniques to represent and leverage the combination of deterministic and probabilistic dependencies found within the ISM. We demonstrate how the ISM provides a flexible language for data integration where unknown or ambiguous relationships can be mitigated.

  9. Antibody tumor penetration

    Science.gov (United States)

    Thurber, Greg M.; Schmidt, Michael M.; Wittrup, K. Dane

    2009-01-01

    Antibodies have proven to be effective agents in cancer imaging and therapy. One of the major challenges still facing the field is the heterogeneous distribution of these agents in tumors when administered systemically. Large regions of untargeted cells can therefore escape therapy and potentially select for more resistant cells. We present here a summary of theoretical and experimental approaches to analyze and improve antibody penetration in tumor tissue. PMID:18541331

  10. Incorporating domain knowledge in chemical and biomedical named entity recognition with word representations

    OpenAIRE

    Munkhdalai, Tsendsuren; Li, Meijing; Batsuren, Khuyagbaatar; Park, Hyeon Ah; Choi, Nak Hyeon; Ryu, Keun Ho

    2015-01-01

    Background Chemical and biomedical Named Entity Recognition (NER) is an essential prerequisite task before effective text mining can begin for biochemical-text data. Exploiting unlabeled text data to leverage system performance has been an active and challenging research topic in text mining due to the recent growth in the amount of biomedical literature. We present a semi-supervised learning method that efficiently exploits unlabeled data in order to incorporate domain knowledge into a named...

  11. Ontology Temporal Evolution for Multi-Entity Bayesian Networks under Exogenous and Endogenous Semantic Updating

    OpenAIRE

    Mas, Massimiliano Dal

    2010-01-01

    It is a challenge for any Knowledge Base reasoning to manage ubiquitous uncertain ontology as well as uncertain updating times, while achieving acceptable service levels at minimum computational cost. This paper proposes an application-independent merging ontologies for any open interaction system. A solution that uses Multi-Entity Bayesan Networks with SWRL rules, and a Java program is presented to dynamically monitor Exogenous and Endogenous temporal evolution on updating merging ontologies...

  12. Ontology Temporal Evolution for Multi-Entity Bayesian Networks under Exogenous and Endogenous Semantic Updating

    CERN Document Server

    Mas, Massimiliano Dal

    2010-01-01

    It is a challenge for any Knowledge Base reasoning to manage ubiquitous uncertain ontology as well as uncertain updating times, while achieving acceptable service levels at minimum computational cost. This paper proposes an application-independent merging ontologies for any open interaction system. A solution that uses Multi-Entity Bayesan Networks with SWRL rules, and a Java program is presented to dynamically monitor Exogenous and Endogenous temporal evolution on updating merging ontologies on a probabilistic framework for the Semantic Web.

  13. Path Prediction and Path Diversion Identifying Methodologies for Hazardous Materials Transported by Malicious Entities

    OpenAIRE

    Nune, Rakesh

    2007-01-01

    Safe and secure transportation of hazardous materials (hazmat) is a challenging issue in terms of optimizing risk to society and simultaneously making the shipment delivery economical. The most important safety concern of hazardous material transportation is accidents causing multiple causalities. The potential risk to society from hazmat transportation has led to the evolution of a new threat from terrorism. Malicious entities can turn hazmat vehicles into weapons causing explosions in high ...

  14. Zosteriform spiradenoma with spiradenocarcinoma: A rare entity

    Directory of Open Access Journals (Sweden)

    Satish A Adulkar

    2015-01-01

    Full Text Available Eccrine spiradenoma (ES is an uncommon well-differentiated benign tumor originating from the sweat glands. It usually occurs as a single lesion in adults. Multiple ES in a linear or zosteriform distribution are rare. Spiradenomacarcinoma is an extremely rare tumor, which develops in an existing benign spiradenoma of several years of duration. We report a case of a 23-year-old- female patient with multiple spiradenomas arranged in zosteriform pattern and malignant transformation occurred in one of the lesions over a period of 10 years.

  15. Zosteriform spiradenoma with spiradenocarcinoma: A rare entity.

    Science.gov (United States)

    Adulkar, Satish A; Dongre, Atul M; Khopkar, Uday S; Maddala, Raghuram; Gole, Prachi V; Chikhalkar, Siddhi

    2015-12-01

    Eccrine spiradenoma (ES) is an uncommon well-differentiated benign tumor originating from the sweat glands. It usually occurs as a single lesion in adults. Multiple ES in a linear or zosteriform distribution are rare. Spiradenomacarcinoma is an extremely rare tumor, which develops in an existing benign spiradenoma of several years of duration. We report a case of a 23-year-old- female patient with multiple spiradenomas arranged in zosteriform pattern and malignant transformation occurred in one of the lesions over a period of 10 years. PMID:26904446

  16. [Epithelioid hemangioendothelioma: an uncommon liver tumor].

    Science.gov (United States)

    Pareja, Eugenia; Cortés, Miriam; Rayon, Miguel; Moya, Angel; Mir, Jose

    2010-01-01

    We report the case of a female patient who was referred to our unit because of a solid liver tumor, suggestive of metastasis. After biopsy, the patient was diagnosed with epithelioid hemangioendothelioma of the liver. Epithelioid hemangioendothelioma is a rare entity with an unpredictable, potentially fatal, clinical course and outcome. Due to its rarity, this entity should be considered when a solitary hepatic lesion is detected and should be included in the differential diagnosis with liver metastases. We highlight the infrequency of this tumor, its presentation as a solitary hepatic lesion and the indication of surgical treatment. We describe the clinical and pathological characteristics of epithelioid hemangioendothelioma of the liver and report a new case of this entity. The distinct therapeutic options are discussed.

  17. ADD psychosis as a separate entity.

    Science.gov (United States)

    Bellak, L

    1985-01-01

    "Attention deficit disorder (ADD) psychosis" merits delineation as a separate entity. It constitutes the end result of the effects of a certain particular neurological deficit (ADD) on personality organization. It is my belief that about 10 percent of psychoses currently diagnosed most often schizophrenic and sometimes affective psychosis must best be considered a separate organic psychosis, i.e., an ADD psychosis. This ADD psychosis, then, is not merely a subgroup of schizophrenia, as I once thought. It merits a separate designation because its etiology, pathogenesis, and life history are different from those of the schizophrenic syndrome. The family histories are also different, as are the psychological findings. The treatment response is so different that it merits urgent consideration. Prognosis, both short range and long range, also seems different from those of the other psychoses. PMID:4081648

  18. Database design using entity-relationship diagrams

    CERN Document Server

    Bagui, Sikha

    2011-01-01

    Data, Databases, and the Software Engineering ProcessDataBuilding a DatabaseWhat is the Software Engineering Process?Entity Relationship Diagrams and the Software Engineering Life Cycle          Phase 1: Get the Requirements for the Database          Phase 2: Specify the Database          Phase 3: Design the DatabaseData and Data ModelsFiles, Records, and Data ItemsMoving from 3 × 5 Cards to ComputersDatabase Models     The Hierarchical ModelThe Network ModelThe Relational ModelThe Relational Model and Functional DependenciesFundamental Relational DatabaseRelational Database and SetsFunctional

  19. WCF multi-layer services development with Entity framework

    CERN Document Server

    Liu, Mike

    2014-01-01

    If you are a C#, VB.NET, or C++ developer and want to get started with WCF and Entity Framework, then this book is for you. Competence in Entity Framework will be needed to follow the examples in the book, but experience in creating WCF services using Entity Framework is not necessary. Developers and architects evaluating SOA implementation technologies for their company will find this book useful.

  20. THE ROLE OF INTERNAL AUDIT WITHIN PUBLIC ENTITIES

    Directory of Open Access Journals (Sweden)

    MARIA MORARU

    2012-05-01

    Full Text Available The auditors have a key role in the development of modern economics and accounting rules in progress. Auditing is a profession that has emerged over the years trying to meet the changing needs which public entities have. Public internal audit activities role is to improve public entities providing management advice for the proper administration of public revenues and expenditures. This paper presents the role of internal audit as a tool in changing the mentality of management and employees of entities.

  1. Detecting Adjacent Relativity of Engineering Drawing Entities with Container Window

    Institute of Scientific and Technical Information of China (English)

    林福严; 邱友申; 秦吉胜

    2001-01-01

    Automatic recognition and interpretation of engineering drawing plays an important role in computer aided engineering. Detecting the positional relation between entities is an important topic in this research field. In this paper the concepts of adjacent relativity and container window of drawing entities were proposed. By means of container window, the adjacent irrelative entities can be detected quickly and effectively, which speeds up the process of adjacent relativity detection. Meanwhile, the algorithm of adjacent relativity detection was discussed.

  2. Public Corporate Governance for Public-sector Entities

    OpenAIRE

    Markus Hafele

    2008-01-01

    This article describes the development of the implementation of a Public Corporate Governance Code for public-sector entities in Germany. It provides a description of a wholly process to implement such regulations for public authority and its entities to improve corporate management, accountability and transparency of the public sector in Germany. Public and private-sector entities operating on the free market must generally be treated equally. Conversely, this means that the public authoriti...

  3. The Claim Tool Kit for ad hoc recognition of peer entities

    DEFF Research Database (Denmark)

    Seigneur, Jean-Marc; Jensen, Christian D.

    2005-01-01

    In ubiquitous/pervasive computing environments, it is envisaged that computing elements—entities—will start interacting in an ad hoc fashion. The peer-to-peer (p2p) paradigm is appealing for such types of interaction especially with JXTA, which supports the development of reusable p2p building bl...... features. Finally, we explain how the CTK can be instrumented to take into account performance assessment. By analysing the evaluation results, the applicability of these advanced Java-based technologies for peer entity recognition is assessed.......In ubiquitous/pervasive computing environments, it is envisaged that computing elements—entities—will start interacting in an ad hoc fashion. The peer-to-peer (p2p) paradigm is appealing for such types of interaction especially with JXTA, which supports the development of reusable p2p building...... number of peers) challenge the use of legacy authentication mechanisms. Supporting spontaneous interactions among previously unknown entities requires dynamic enrolment of strangers and unknown entities. Entity recognition (ER) is a process that is carried out each time an interaction happens between...

  4. How Well can We Learn Interpretable Entity Types from Text?

    DEFF Research Database (Denmark)

    Hovy, Dirk

    2014-01-01

    We investigate a largely unsupervised approach to learning interpretable, domain-specific entity types from unlabeled text. It assumes that any common noun in a domain can function as potential entity type, and uses those nouns as hidden variables in a HMM. To constrain training, it extracts co......-occurrence dictionaries of entities and common nouns from the data. We evaluate the learned types by measuring their prediction accuracy for verb arguments in several domains. The results suggest that it is possible to learn domain-specific entity types from unlabeled data. We show significant improvements over...

  5. System for Award Management (SAM) Public Extract - Entity Registration

    Data.gov (United States)

    General Services Administration — This dataset contains the information available under the Freedom of Information Act (FOIA) for those entities registered to do business with the Federal government...

  6. Cancer stem cells, tumor dormancy, and metastasis

    OpenAIRE

    EmilyChen

    2012-01-01

    Tumor cells can persist undetectably for an extended period of time in primary tumors and in disseminated cancer cells. Very little is known about why and how these tumors persist for extended periods of time and then evolve to malignancy. The discovery of cancer stem cells (CSCs) in human tumors challenges our current understanding of tumor recurrence, drug resistance, and metastasis, and opens up new research directions on how cancer cells are capable of switching from dormancy to malignanc...

  7. Indexing concepts and/or named entities Indicizzare concetti e/o named entities

    Directory of Open Access Journals (Sweden)

    Pino Buizza

    2011-12-01

    Full Text Available

    A partire da un punto di vista semantico più che morfologico, l'articolo è focalizzato il problema del significato dei nomi propri, con contributi della filosofia del linguaggio e della linguistica semantica. Sono indagate le entità individuali: il loro isolamento all’interno della rete di soggetti e la relazione esemplificativa, il trattamento nelle classificazioni. Le profonde diversità rilevate fra concetti e entità denominate suggeriscono di dichiararle esplicitamente da un punto di vista teorico e di adottare dispositivi che diano risultati unitari ma chiaramente distinguibili nei sistemi di recupero dell’informazione.  
    Questo contributo è stato presentato col titolo Indexing concepts and/or named entities all'11th ISKO Conference, Paradigms and conceptual systems in knowledge organization, Roma, 23-26 febbraio 2010, non pubblicato negli atti, e qui leggermente ampliato.

    Starting from a semantic rather than form a morphological point of view, the essay examines the problem of the meaning of proper names, with contributions coming from the philosophy of language and the semantic linguistics. Individual entities are explored: the way they are isolated in the thread of subjects, the illustrative relation, and the classification treatment. The deep differences between concepts and called entities suggest to declare them specifically in a theoretical way, and to adopt devices that lead to uniform but noticeable results in information retrieval systems.
    This article has been discussed as "Indexing concepts and/or named entities" to the 11th ISKO Conference, Paradigms and conceptual systems in knowledge organization, Rome, 23-26 February 2010, here extended since it is not published in the conference proceedings.

  8. Challenges in management of patients with intracranial germ cell tumor and diabetes insipidus treated with cisplatin and/or ifosfamide based chemotherapy.

    Science.gov (United States)

    Afzal, Samina; Wherrett, Diane; Bartels, Ute; Tabori, Uri; Huang, Annie; Stephens, Derek; Bouffet, Eric

    2010-05-01

    Patients with intracranial germ cell tumor (IGCT) often present with pituitary dysfunction, including diabetes insipidus (DI). Recent protocols have used pre-radiation chemotherapy with combinations of etoposide, carboplatin and/or cisplatin, and ifosfamide. Management of DI in these patients requires monitoring of electrolytes and fluids during chemotherapy and hyperhydration. All consecutive patients treated with chemotherapy for an IGCT during the period 1990-2007 at the Hospital for Sick Children, Toronto were reviewed. Out of 32 patients who received chemotherapy, 21 had DI. Only cycles containing cisplatin and/or ifosfamide and hyperhydration were considered. DI and non-DI patients were compared for each cycle of chemotherapy. Patients were studied for number of days in hospital per chemotherapy course, daily fluid input and output, changes in dose, schedule and route of administration of desmopressin (DDAVP) during chemotherapy, daily variations in sodium level, electrolyte monitoring requirements per day, and complications related to fluid and electrolyte disturbances. Fifty-four cycles of chemotherapy in DI patients were compared to 25 cycles in non DI patients. All 21 patients with DI required daily change in dosage and schedule of DDAVP. Marked variations in daily sodium level were observed in the DI group. Seventeen courses required prolonged admission in the DI group (one in non DI patients) and 6 patients experienced serious complications. In conclusion, DI is a risk factor for complications when cisplatin and/or ifosfamide based protocols are used. The role of these agents in the management of ICGT should be carefully evaluated and guidelines for management of DI established. PMID:19820898

  9. Tumor vaccines

    International Nuclear Information System (INIS)

    Tumor vaccines have several potential advantages over standard anticancer regiments. They represent highly specific anticancer therapy. Inducing tumor-specific memory T-lymphocytes, they have potential for long-lived antitumor effects. However, clinical trials, in which cancer patients were vaccinated with tumor vaccines, have been so far mainly disappointing. There are many reasons for the inefficiency of tumor vaccines. Most cancer antigens are normal self-molecules to which immune tolerance exists. That is why the population of tumor-specific lymphocytes is represented by a small number of low-affinity T-lymphocytes that induce weak antitumor immune response. Simultaneously, tumors evolve many mechanisms to actively evade immune system, what makes them poorly immunogenic or even tolerogenic. Novel immunotherapeutic strategies are directed toward breaking immune tolerance to tumor antigens, enhancing immunogenicity of tumor vaccines and overcoming mechanisms of tumor escape. There are several approaches, unfortunately, all of them still far away from an ideal tumor vaccine that would reject a tumor. Difficulties in the activation of antitumor immune response by tumor vaccines have led to the development of alternative immunotherapeutic strategies that directly focus on effector mechanisms of immune system (adoptive tumor- specific T-lymphocyte transfer and tumor specific monoclonal antibodies). (author)

  10. Primary renal teratoma: a rare entity

    OpenAIRE

    Idrissi-Serhrouchni, Karima; El-Fatemi, Hinde; El Madi, Aziz; Benhayoun, Khadija; Chbani, Laila; Harmouch, Taoufik; Bouabdellah, Youssef; Amarti, Afaf

    2013-01-01

    Abstract Teratomas are neoplasms that arise from pluripotent cells and can differentiate along one or more embryonic germ lines. Renal teratoma is an exceedingly rare condition. Teratomas commonly arise in the gonads, sacrococcygeal region, pineal gland, and retroperitoneum. They present mainly as an abdominal mass with few other symptoms. Majority of the tumors are benign, situated on the left side and para renal, occasional lesions are bilateral. If diagnosed early, they are amenable to cur...

  11. Prolonged ulcerative laryngitis: a new disease entity.

    Science.gov (United States)

    Hsiao, Tzu-Yu

    2011-03-01

    Over the last decade, a new disease entity, prolonged ulcerative laryngitis (PUL), with unique clinical presentation and prolonged disease course, has been recognized. Until now, very few studies dealing with this disease have been reported in the literature. From 1999 to 2008, we analyzed clinical data from a series of 39 PUL patients who were treated with an observational approach without implementing specific treatments. This disease affects adults, predominantly females. The age of patients in our series ranged from 26 to 76 years with a median of 49.5 years. This disease is characterized by ulcers and signs of acute inflammation on the membranous portion of the vocal folds with a prolonged clinical course. The recovery times of patients ranged from 4 to 20 weeks with an average of 9.4 weeks. The data in this study may reflect a natural history of this disease. PUL seems to be a self-limited disease, but the etiology of this disease is unknown. Specific infections or systemic inflammatory processes involving the larynx must be ruled out before diagnosis, and conservative treatments are suggested.

  12. Building entity models through observation and learning

    Science.gov (United States)

    Garcia, Richard; Kania, Robert; Fields, MaryAnne; Barnes, Laura

    2011-05-01

    To support the missions and tasks of mixed robotic/human teams, future robotic systems will need to adapt to the dynamic behavior of both teammates and opponents. One of the basic elements of this adaptation is the ability to exploit both long and short-term temporal data. This adaptation allows robotic systems to predict/anticipate, as well as influence, future behavior for both opponents and teammates and will afford the system the ability to adjust its own behavior in order to optimize its ability to achieve the mission goals. This work is a preliminary step in the effort to develop online entity behavior models through a combination of learning techniques and observations. As knowledge is extracted from the system through sensor and temporal feedback, agents within the multi-agent system attempt to develop and exploit a basic movement model of an opponent. For the purpose of this work, extraction and exploitation is performed through the use of a discretized two-dimensional game. The game consists of a predetermined number of sentries attempting to keep an unknown intruder agent from penetrating their territory. The sentries utilize temporal data coupled with past opponent observations to hypothesize the probable locations of the opponent and thus optimize their guarding locations.

  13. Marine Natural Products as Inhibitors of Hypoxic Signaling in Tumors

    OpenAIRE

    Nagle, Dale G.; Zhou, Yu-Dong

    2009-01-01

    Marine natural products have become a major source of new chemical entities in the discovery of potential anticancer agents that potently suppress various antitumor molecular targets. As a consequence of insufficient vascularization, hypoxic regions form within rapidly growing solid tumor masses. Specific alterations of gene expression in these hypoxic tumor cells help facilitate the survival and metastatic spread of solid tumors. The transcriptional response to cellular hypoxia is primarily ...

  14. Congenital peribronchial myofibroblastic tumor: Case report and review of literature

    OpenAIRE

    Jolanta Jedrzkiewicz; Eric Scaife; Bo Hong; Sarah South; Mouied Alashari

    2015-01-01

    Congenital peribronchial myofibroblastic tumor (CPMT) is a rare entity recognized in the WHO classification of pulmonary neoplasms. According to available literature, it is a benign tumor with a high mortality rate exceeding 50%. It is partially attributed to polyhydramnios, hydrops, prematurity, respiratory distress or adverse surgical outcomes due to intraoperative bleeding. Herein we present a case of congenital peribronchial myofibroblastic tumor in a premature male infant who was born at...

  15. 43 CFR 426.8 - Nonresident aliens and foreign entities.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Nonresident aliens and foreign entities..., DEPARTMENT OF THE INTERIOR ACREAGE LIMITATION RULES AND REGULATIONS § 426.8 Nonresident aliens and foreign... reclamation law or these regulations, a nonresident alien or foreign entity that directly holds land in...

  16. 31 CFR 306.88 - Political entities and public corporations.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Political entities and public... GOVERNING U.S. SECURITIES Assignments in Behalf of Private or Public Organizations § 306.88 Political..., city, town, village, school district or other political entity, public body or corporation, may...

  17. 37 CFR 253.2 - Definition of public broadcasting entity.

    Science.gov (United States)

    2010-07-01

    ... CONNECTION WITH NONCOMMERCIAL EDUCATIONAL BROADCASTING § 253.2 Definition of public broadcasting entity. As... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Definition of public broadcasting entity. 253.2 Section 253.2 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY...

  18. 78 FR 45051 - Unincorporated Business Entities; Effective Date

    Science.gov (United States)

    2013-07-26

    ... institutions' use of unincorporated business entities organized under State law for certain business activities... business entities (UBEs) organized under State law for certain business activities. A UBE includes limited... business trusts, organized under State law. The final rule does not apply to UBEs that one or more...

  19. Event-Entity-Relationship Modeling in Data Warehouse Environments

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    We use the event-entity-relationship model (EVER) to illustrate the use of entity-based modeling languages for conceptual schema design in data warehouse environments. EVER is a general-purpose information modeling language that supports the specification of both general schema structures and multi...

  20. 14 CFR Sec. 1-6 - Accounting entities.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Accounting entities. Sec. 1-6 Section 1-6... REGULATIONS UNIFORM SYSTEM OF ACCOUNTS AND REPORTS FOR LARGE CERTIFICATED AIR CARRIERS General Accounting Provisions Sec. 1-6 Accounting entities. (a) Separate accounting records shall be maintained for each...

  1. Brain Tumors

    Science.gov (United States)

    A brain tumor is a growth of abnormal cells in the tissues of the brain. Brain tumors can be benign, with no cancer cells, ... cancer cells that grow quickly. Some are primary brain tumors, which start in the brain. Others are ...

  2. Urogenital tumors

    Energy Technology Data Exchange (ETDEWEB)

    Weller, R.E.

    1994-03-01

    An overview is provided for veterinary care of urogenital tumors in companion animals, especially the dog. Neoplasms discussed include tumors of the kidney, urinary bladder, prostate, testis, ovary, vagina, vulva and the canine transmissible venereal tumor. Topics addressed include description, diagnosis and treatment.

  3. Odontogenic Tumors

    OpenAIRE

    TAHSİNOĞLU, Melih

    2013-01-01

    DefinitionThe neoplasms that consist of the cells considered specialized for odontogenesis, and their product (dentin, enamel, cementum) are called odontogenic tumors.ClassificationTo initiate odontogenesis, epithelium is a must. Same rule holds for the odontogenic tumors: without odontogenic epithelium, odontogenic tumors cannot be, without the induction of odontogenic epithelium odontogenic mesenchyme cannot develop.

  4. Tumor Markers

    Science.gov (United States)

    ... guidelines on a variety of topics, including tumor markers for breast cancer, colorectal cancer, lung cancer, and others. The ... of recurrence 70-Gene signature (Mammaprint®) Cancer type: Breast ... Can tumor markers be used in cancer screening? Because tumor markers ...

  5. Molecular subtypes of serous borderline ovarian tumor show distinct expression patterns of benign tumor and malignant tumor-associated signatures.

    Science.gov (United States)

    Curry, Edward W J; Stronach, Euan A; Rama, Nona R; Wang, Yuepeng Y P; Gabra, Hani; El-Bahrawy, Mona A

    2014-03-01

    Borderline ovarian tumors show heterogeneity in clinical behavior. Most have excellent prognosis, although a small percentage show recurrence or progressive disease, usually to low-grade serous carcinoma. The aim of this study was to understand the molecular relationship between these entities and identify potential markers of tumor progression and therapeutic targets. We studied gene expression using Affymetrix HGU133plus2 GeneChip microarrays in 3 low-grade serous carcinomas, 13 serous borderline tumors and 8 serous cystadenomas. An independent data set of 18 serous borderline tumors and 3 low-grade serous carcinomas was used for validation. Unsupervised clustering revealed clear separation of benign and malignant tumors, whereas borderline tumors showed two distinct groups, one clustering with benign and the other with malignant tumors. The segregation into benign- and malignant-like borderline molecular subtypes was reproducible on applying the same analysis to an independent publicly available data set. We identified 50 genes that separate borderline tumors into their subgroups. Functional enrichment analysis of genes that separate borderline tumors to the two subgroups highlights a cell adhesion signature for the malignant-like subset, with Claudins particularly prominent. This is the first report of molecular subtypes of borderline tumors based on gene expression profiling. Our results provide the basis for identification of biomarkers for the malignant potential of borderline ovarian tumor and potential therapeutic targets for low-grade serous carcinoma. PMID:23948749

  6. Metronomic topotecan impedes tumor growth of MYCN-amplified neuroblastoma cells in vitro and in vivo by therapy induced senescence.

    Science.gov (United States)

    Taschner-Mandl, Sabine; Schwarz, Magdalena; Blaha, Johanna; Kauer, Maximilian; Kromp, Florian; Frank, Nelli; Rifatbegovic, Fikret; Weiss, Tamara; Ladenstein, Ruth; Hohenegger, Martin; Ambros, Inge M; Ambros, Peter F

    2016-01-19

    Poor prognosis and frequent relapses are major challenges for patients with high-risk neuroblastoma (NB), especially when tumors show MYCN amplification. High-dose chemotherapy triggers apoptosis, necrosis and senescence, a cellular stress response leading to permanent proliferative arrest and a typical senescence-associated secretome (SASP). SASP components reinforce growth-arrest and act immune-stimulatory, while others are tumor-promoting. We evaluated whether metronomic, i.e. long-term, repetitive low-dose, drug treatment induces senescence in vitro and in vivo. And importantly, by using the secretome as a discriminator for beneficial versus adverse effects of senescence, drugs with a tumor-inhibiting SASP were identified.We demonstrate that metronomic application of chemotherapeutic drugs induces therapy-induced senescence, characterized by cell cycle arrest, p21(WAF/CIP1) up-regulation and DNA double-strand breaks selectively in MYCN-amplified NB. Low-dose topotecan (TPT) was identified as an inducer of a favorable SASP while lacking NFKB1/p50 activation. In contrast, Bromo-deoxy-uridine induced senescent NB-cells secret a tumor-promoting SASP in a NFKB1/p50-dependent manner. Importantly, TPT-treated senescent tumor cells act growth-inhibitory in a dose-dependent manner on non-senescent tumor cells and MYCN expression is significantly reduced in vitro and in vivo. Furthermore, in a mouse xenotransplant-model for MYCN-amplified NB metronomic TPT leads to senescence selectively in tumor cells, complete or partial remission, prolonged survival and a favorable SASP.This new mode-of-action of metronomic TPT treatment, i.e. promoting a tumor-inhibiting type of senescence in MYCN-amplified tumors, is clinically relevant as metronomic regimens are increasingly implemented in therapy protocols of various cancer entities and are considered as a feasible maintenance treatment option with moderate adverse event profiles. PMID:26657295

  7. 76 FR 78146 - Addition of Certain Persons to the Entity List; and Implementation of Entity List Annual Review...

    Science.gov (United States)

    2011-12-16

    ... P.O. Box: 25123, Dubai U.A.E. Annual Review of the Entity List This rule also amends the Entity List... by the Notice of August 12, 2011, 76 FR 50661 (August 16, 2011), has continued the Export... law, pursuant to Executive Order 13222. Rulemaking Requirements 1. Executive Orders 13563 and...

  8. Enriched vascularity in ameloblastomas, an indeterminate entity: Report of two cases

    Directory of Open Access Journals (Sweden)

    Usha Hegde

    2015-01-01

    Full Text Available Vascularity is a highly essential element that is required for the growth, development, and functioning of the body and variations in it can cause pathologies. It is one of the prime features of a proliferating lesion, where it aids in the growth of the lesion through its nutrition supply. Highly increased vascularity in a disease can itself affect the prognosis of the lesion, and in malignancies, it can induce tumor seeding and secondaries. Most of the pathologies including tumors, related to blood vessels, and vascularity are well established. There are some conditions, wherein altered vascularity is one of the prime components along with other diagnostic components of an established disease. In such cases, these lesions are diagnosed with special names, with varying biological behavior and prognosis in comparison to that of established entity. However, there still are few similar conditions whose nature is uncertain due to the rarity of the lesion and the insufficient scientific evidence which eludes the diagnostician. Here is the report of two cases of ameloblastoma, an established entity, with significant vascularity whose nature is indeterminate.

  9. Primary tumors of the patella.

    Science.gov (United States)

    Song, Mingzhi; Zhang, Zhen; Wu, Yuxuan; Ma, Kai; Lu, Ming

    2015-01-01

    The patella is an uncommon location for cancerous occurrence and development. The majority of tumors of the patella are benign, with a significant incidence of giant cell tumors and chondroblastoma. With the development of modern diagnostic technologies, there appear however many other histological types which raise challenges of diagnosis and treatment. In this article, we review the reported histological types of primary patellar tumors. Specifically, epidemiology, symptomatology, imageology, histopathology, and treatment options for these histological lesions will be discussed, respectively. As there is an increasing focus on the diagnosis and the treatment of these lesions, the availability of the integrated information about primary patellar tumors becomes more significant. PMID:25906772

  10. Mucosal Schwann cell "Hamartoma": A new entity?

    Institute of Scientific and Technical Information of China (English)

    Paola Pasquini; Andrea Baiocchini; Laura Falasca; Dante Annibali; Guido Gimbo; Francesco Pace; Franca Del Nonno

    2009-01-01

    Schwannoma is a well-described, benign nerve sheath tumor of the soft tissue, but is rare in the gastrointestinal tract. Gastrointestinal schwannomas are often incidentally discovered as small polypoid intraluminal lesions. In this report, we describe the clinicopathologic and immunohistochemical features of a distinctive neural mucosal polyp composed of a diffuse cellular proliferation of uniform bland spindled cells in the lamina propria that entraps the colonic crypts. Immunohistochemical analysis revealed strong and diffuse positivity for the S-100 protein. To avoid confusion of these solitary colorectal polyps containing pure spindled Schwann cell proliferation in the lamina propria with neural lesions that have significant association with inherited syndromes, it is better to use the designation "mucosal Schwann hamartoma".

  11. Poikiloderma vasculare atrophicans: A distinct clinical entity?

    Directory of Open Access Journals (Sweden)

    Vikram K Mahajan

    2015-01-01

    Full Text Available This paper describes a typical case of poikiloderma vasculare atrophicans (PVA in a 48-year-old female. Histologically, the features were suggestive of PVA with the absence of Pautrier′s microabscess or atypical lymphoid cells. The biopsy specimen was positive for cluster of differentiation (CD 8 on immunohistochemical staining. Its exact pathogenesis remains obscure, and it remains unclear whether PVA actually is mycosis fungoides (MF, a forme fruste of MF, or a distinct and benign dermatosis with CD8+ phenotype that can perhaps be labeled as PVA. However, it has a long benign clinical course without progression to tumor stage of MF in most cases, and its status within the spectrum of cutaneous T-cell lymphoma remains poorly understood. Yet it is imperative to distinguish PVA from poikilodermic MF.

  12. IDENTIFYING AND IMPLEMENTATION OF THE FINANCING SOURCES OF TOURIST ENTITIES

    Directory of Open Access Journals (Sweden)

    Gabriela DAVID

    2015-12-01

    Full Text Available Located at the intersection of the two spheres (tourism markets and financial ones, the tourism entity in Romania is interested in finding the formula to assure optimum financing by attracting financial resources in the field, on the one hand and on the other hand it is interested in meeting the high demand for profit from tourism and economic sphere. The objective determinant of Romanian tourism entity is to maximize the value by carrying out a profitable activity. The touristic entity must obtain profit to generate sufficient funds to distribute cash dividends to shareholders, while paying creditors at a favorable interest on borrowed funds.

  13. Concrete Security for Entity Recognition: The Jane Doe Protocol

    DEFF Research Database (Denmark)

    Lucks, Stefan; Zenner, Erik; Weimerskirch, Andre;

    2008-01-01

    Entity recognition does not ask whether the message is from some entity X, just whether a message is from the same entity as a previous message. This turns turns out to be very useful for low-end devices. The current paper proposes a new protocol – the “Jane Doe Protocol” –, and provides a formal...... proof of its concrete security. The protocol neither employs asymmetric cryptography, nor a trusted third party, nor any key pre-distribution. It is suitable for light-weight cryptographic devices such as sensor network motes and RFID tags....

  14. 78 FR 21603 - Proposed Reporting Entity; Request for Comments

    Science.gov (United States)

    2013-04-11

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Proposed Reporting Entity; Request for Comments AGENCY: Federal Accounting Standards..., notice is hereby given that the Federal Accounting Standards Advisory Board is seeking input on...

  15. Risk Management Measures at the Level of an Economic Entity

    OpenAIRE

    Dan NASTASE; Liviu Constantin TEODORESCU; Ionut POPESCU

    2014-01-01

    There are strategies for continuous monitoring of the level of risk facing the entity. Their use causes a reduction in the firm ‘s vulnerability to environmental conditions , and a reduction in losses that might occur if the risk .

  16. Ambulatory surgery center joint ventures involving tax-exempt entities.

    Science.gov (United States)

    Becker, S; Pristave, R J; McConnell, W

    1999-01-01

    This article provides an overview of the tax-exempt related issues for ambulatory surgery center joint ventures involving tax-exempt entities. The article analyzes the key points of analysis of the guidance released by the IRS, in particular General Counsel Memorandum 39862, Revenue Ruling 98-15, and Redlands Surgical Services v. Commissioner of the Internal Revenue Service. These key points include whether the venture results in private inurement to insiders and whether the venture furthers the charitable purposes of the tax-exempt entity. The article also provides practical guidance to analyze the documents and structure of the joint venture to ensure compliance with the IRS guidance. These practical considerations include, among other things, whether the charitable purposes of the tax-exempt entity are clearly expressed in the documents and whether the tax-exempt entity has sufficient control over the joint venture to ensure the charitable purposes are being adhered to.

  17. Named Entity Recognition Based on A Machine Learning Model

    Directory of Open Access Journals (Sweden)

    Jing Wang

    2012-09-01

    Full Text Available For the recruitment information in Web pages, a novel unified model for named entity recognition is proposed in this study. The models provide a simple statistical framework to incorporate a wide variety of linguistic knowledge and statistical models in a unified way. In our approach, firstly, Multi-Rules are built for a better representation of the named entity, in order to emphasize the specific semantics and term space in the named entity. Then an optimal algorithm of the hierarchically structured DSTCRFs is performed, in order to pick out the structure attributes of the named entity from the recruitment knowledge and optimize the efficiency of the training. The experimental results showed that the accuracy rate has been significantly improved and the complexity of sample training has been decreased.

  18. TONGUE BASE SCHWANNOMA : A RARE ENTITY

    Directory of Open Access Journals (Sweden)

    Vivek

    2015-03-01

    Full Text Available INTRODUCTION: Schwannomas are the benign tumours arising from the Schwann cells. Intraoral and pharyngeal schwannomas are rare and constitute less than 1%. CASE REPORT: We report a case of a 39 year old lady who presented with progressive dysphagia and dysphonia since three months. Intraoral examination showed a well - defined reddish lesion arising from the base of the tongue. She was referred to the department of radiodiagnosis for CT and MRI of the neck to know the extent of the lesion. Differential diagnosis of schwannoma and minor salivary gland tumor was given. Excision biopsy of the lesion was done and the histologic examination showed it as schwannoma. DISCUSSION: Schwannomas of the base of the tongue are rare and should be included in the differential diagnosis based on the imaging features and enhancem ent pattern. CONCLUSION: Imaging features, particularly MRI with contrast helps in differentiating benign from malignant lesions of the base of the tongue. Schwannomas are benign and have good prognosis as they can be excised when compared to the other intraoral malignant lesions.

  19. Genetically engineered mouse models of pituitary tumors

    OpenAIRE

    DavidACano; AlfonsoSoto-Moreno

    2014-01-01

    Animal models constitute valuable tools for investigating the pathogenesis of cancer as well as for preclinical testing of novel therapeutics approaches. However, the pathogenic mechanisms of pituitary tumor formation remain poorly understood, particularly in sporadic adenomas, thus making it a challenge to model pituitary tumors in mice. Nevertheless, genetically engineered mouse models (GEMMs) of pituitary tumors have provided important insight into pituitary tumor biology. In this paper, w...

  20. Proliferating trichilemmal tumor of the nose *

    OpenAIRE

    Aristóteles Rosmaninho; Mónica Caetano; Ana de Oliveira; Teresa Pinto de Almeida; Manuela Selores; Rosário Alves

    2012-01-01

    Proliferating trichilemmal tumor is a rare tumor originating in the external root sheath, that is usually found in the scalp of middle-aged or elderly females. Its histologic appearance may not correlate with its clinical behavior. In addition, there are no guidelines available for the treatment of these tumors, making its management a challenge for physicians. We report the case of a 53 year-old woman with a proliferating trichilemmal tumor on her nose, which is a very uncommon location for ...

  1. Problem aspects of accounting policies forming of public sector entities

    OpenAIRE

    Писарчук, Оксана Володимирівна; Кудіна, Ольга Миколаївна; Тютлікова, Вікторія Валеріївна

    2015-01-01

    This article discusses the problem of forming effective accounting policies of public sector entities, which in the present conditions of high financial instability and the lack of real economic development of the national economy has particular relevance and requires the development of scientific and applied approaches.The purpose of the article is to identify problematic aspects of formation and use of administrative documents on the accounting policies of public sector entity.It is develop...

  2. THE ROLE OF INTERNAL AUDIT WITHIN PUBLIC ENTITIES

    OpenAIRE

    MARIA MORARU; FRANCA DUMITRU

    2012-01-01

    The auditors have a key role in the development of modern economics and accounting rules in progress. Auditing is a profession that has emerged over the years trying to meet the changing needs which public entities have. Public internal audit activities role is to improve public entities providing management advice for the proper administration of public revenues and expenditures. This paper presents the role of internal audit as a tool in changing the mentality of management and employees of...

  3. PERFORMANCE ANALYSIS OF AN ENTITY FROM CONSTRUCTION SECTOR USING DASHBOARD

    OpenAIRE

    SORIN BRICIU; SORINEL CĂPUȘNEANU; DAN IOAN TOPOR; CRISTIAN-MARIAN BARBU; ANAMARIA ȚEPEȘ-BOBESCU

    2015-01-01

    This research paper deals with the analysis of performances of economic entities from the construction sector from Romania. The necessary data for preparation and analysis up through dashboard of the economic entity are provided by managerial accounting through Target Costing method. The way of implementing and observing of stages which are completed in managerial accounting through Target Costing method are also presented in the paper based on the existing literature. For data an...

  4. CONTROVERSIAL ASPECTS REGARDING APPOINTING AND REVOKING THE LEGAL ENTITY ADMINISTRATOR

    OpenAIRE

    CARMEN TODICA

    2012-01-01

    Having as main objective the analysis the provisions of Company Law and the New Civil Code regarding the management of a trading company by a legal person, the study offers several solutions to a number of controversial issues with strict reference to two aspects: appointing and revoking the legal entity administrator. Can the administrator be any entity with a legal personality or just a trade company? Is the administrator subject to legal requirements of good repute, characteristic to a rep...

  5. Named Entity Recognition in Turkish Using Association Measures

    Directory of Open Access Journals (Sweden)

    Senem Kumova Metin

    2012-08-01

    Full Text Available Named Entity Recognition which is an important subject of Natural Language Processing is a key technology of information extraction, information retrieval, question answering and other text processing applications. In this study, we evaluate previously well-established association measures as an initial attempt to extract two-worded named entities in a Turkish corpus. Furthermore we propose a new association measure, and compare it with the other methods. The evaluation of these methods is performed by precision and recall measures.

  6. Quality of the Accounting Information of Brazilian Third Sector Entities

    OpenAIRE

    Fernando Maciel Ramos; Roberto Carlos Klann

    2015-01-01

    In this study, the objective was to analyze the quality of accounting information of Brazilian non-profit organizations. As for the objective the research is characterized as a descriptive one; as for the research strategy it is documental and as for the approach it is quantitative. In order to measure the quality of the accounting information of the analyzed entities, it was prepared a checklist starting from the accounting rules that guide the accounting practice of the third sector entitie...

  7. THE CORPORATE GOVERNANCE OF PUBLIC ENTITIES IN ROMANIA

    OpenAIRE

    Daniela Zapodeanu; Marcel Bolos; Lucia Kolozsi

    2009-01-01

    The paper aims to examine the application of principles of corporate governance fortransparency and efficiency of decision and control at the level of local public entities. We intend toargue the importance of these principles of governance in the public entities to determineresponsibility and management decision-making bodies in achieving the objectives in terms ofreliability of financial reporting, effectiveness and efficiency of operations, compliance withapplicable legislation.

  8. The Entity Registry System. From concept to deployment

    OpenAIRE

    Gramada, Mihai

    2016-01-01

    The entity registry system (ERS) is a decentralized entity registry that can be used to replace the Web as a platform for publishing linked data when the latter is not available. In developing countries, where off-line is the default mode of operation, centralized linked data solutions fail to address the needs of the communities. Although the features are mostly completed, the system is not yet ready for deployment. This project aims to provide extensive tests and scalability investigations ...

  9. Cost and Efficiency Analysis of NEMO Protocol Entities

    Directory of Open Access Journals (Sweden)

    Md Shohrab Hossain

    2012-03-01

    Full Text Available To support IP-mobility of networks in motion, IETF proposed Network Mobility (NEMO protocol that uses various signaling messages to ensure connectivity of the mobile nodes with the Internet and to maintain security of ongoing sessions by protecting the binding updates. As the next-generation wireless and mobile network is supposed to be a unified network basedon all-IP technology, compounded by the fact that the numberof mobile nodes requiring mobility support has increased significantly, the cost analysis of mobility protocols and the underlying mobility management entities have become essential to avoid their performance degradation. However, there has been no comprehensive cost analysis of NEMO protocol entities that considers all possible costs. In this paper, we have developed analytical models to estimate total costs of key mobility management entities of NEMO. We have defined a metric to compute the efficiency of mobility protocol as well as the mobility entities to find out the percentage of resources used for data (payload delivery. We have presented numerical results to demonstrate the impact of network size, mobility rate, traffic rate and data volume on the total costs and the efficiency of the NEMO protocol and its key entities. Our results show that a significant amount of resources (bandwidth, processing power, transmission power are required by the mobility entities for transmission, processing of various signaling messages, as well as searching location database. Our cost analysis will thus help network engineers in estimating actual resource requirements for the key entities of the network in future design while analyzing the data transmission efficiencies of these entities.

  10. A Comparative Study of Accounting Entities Under Different Business Organizations

    Institute of Scientific and Technical Information of China (English)

    LUO Hong-lan; XU Guo-xin; FAN Jin

    2001-01-01

    In terms of accounting, all types of business enterprises regardless of their organizational form are separate accounting entities. But different types of organization forms entail remarkable differences in the establishments, legal positions, liabilities, taxation obligations and accounting practices of the business enterprises as accounting entities. A good knowledge of such difference is beneficial to the promotion of the development of all types of business enterprises in China.

  11. Considering the health care entity C corporation conversion to tax pass-through entity status.

    Science.gov (United States)

    Reilly, Robert F

    2012-01-01

    The double taxation of C corporation income from operations and from the ultimate sale of its assets makes the C corporation an inefficient tax status for many health care entities. At the time of this writing, the changes in the federal tax law that are scheduled to take effect in 2013 will increase this level of double-taxation inefficiency. The owners of a C corporation practice can avoid the C corporation status tax inefficiency by converting the practice to either (1) S corporation status or (2) LLC status. The conversion of the health care C corporation to an S corporation may be accomplished without a current tax cost. However, the conversion of a health care C corporation to an LLC status can result in a current tax at both the corporation level and the shareholder level. Nonetheless, the current conversion tax cost may be less than the future tax cost (1) of operating the practice as a C corporation and incurring double taxation at what may be higher tax rates or (2) of incurring the higher tax cost (or reduced price) on the ultimate disposition of the practice assets and the attendant double taxation of the appreciation in the value of the practice assets. Since individual income tax rates on qualifying dividends from C corporations and on capital gains are currently at very low rates, this may be a good time for C corporation practice owners to consider the costs and benefits of a conversion to either S corporation status or LLC status. The practice owners should consult with their accounting, legal, and valuation advisors in order to consider all of the costs and benefits of a possible corporate tax status conversion. An estimation of both the costs and benefits of the corporate tax status conversion depends on the concluded fair market values of the medical practice, dental practice, or other health care entity assets. And, that practice asset appraisal should encompass all of the practice assets, both tangible assets and intangible assets.

  12. THE PLACE OF THE FORCED LIQUIDATION OF LEGAL ENTITIES IN THE SYSTEM OF CIVIL LIABILITY

    OpenAIRE

    Dmitriy Scheglov

    2015-01-01

    The definition of forced liquidation of the legal entity, the study of existing scientific approaches to the definition of the concept, an analysis of the legal entity attributes classification of legal entities, depending on the grounds for compulsory liquidation.

  13. Opinion groups formation and dynamics : structures that last from non lasting entities

    CERN Document Server

    Grauwin, Sébastian

    2015-01-01

    We extend simple opinion models to obtain stable but continuously evolving communities. Our scope is to meet a challenge raised by sociologists of generating "structures that last from non lasting entities". We achieve this by introducing two kinds of noise on a standard opinion model. First, agents may interact with other agents even if their opinion difference is large. Second, agents randomly change their opinion at a constant rate. We show that for a large range of control parameters, our model yields stable and fluctuating polarized states, where the composition and mean opinion of the emerging groups is fluctuating over time.

  14. Integrating Semantic Features for Enhancing Arabic Named Entity Recognition

    Directory of Open Access Journals (Sweden)

    Hamzah A. Alsayadi

    2016-03-01

    Full Text Available Named Entity Recognition (NER is currently an essential research area that supports many tasks in NLP. Its goal is to find a solution to boost accurately the named entities identification. This paper presents an integrated semantic-based Machine learning (ML model for Arabic Named Entity Recognition (ANER problem. The basic idea of that model is to combine several linguistic features and to utilize syntactic dependencies to infer semantic relations between named entities. The proposed model focused on recognizing three types of named entities: person, organization and location. Accordingly, it combines internal features that represented linguistic features as well as external features that represent the semantic of relations between the three named entities to enhance the accuracy of recognizing them using external knowledge source such as Arabic WordNet ontology (ANW. We introduced both features to CRF classifier, which are effective for ANER. Experimental results show that this approach can achieve an overall F-measure around 87.86% and 84.72% for ANERCorp and ALTEC datasets respectively.

  15. Poorly differentiated forms of papillary thyroid carcinoma: distinctive entities or morphological patterns?

    Science.gov (United States)

    Pilotti, S; Collini, P; Manzari, A; Marubini, E; Rilke, F

    1995-08-01

    The concept that poorly differentiated carcinomas (PDC) represent a group in an intermediate position in the spectrum of follicular cell-derived carcinomas of the thyroid gland is currently well established. Because at the well-differentiated end of the spectrum there are two groups of entities with distinct biological characteristics, ie, the papillary carcinoma (PC) and the follicular carcinoma (FC), we examined the group represented by PCs to ascertain whether papillary carcinoma-related PDCs (pPDC) represent merely a histologic variant or a distinct pathologic entity. For this purpose 227 consecutive PCs were reclassified according to current criteria. The association between the presence of a tumoral pattern consistent with pPDC (response variable), and prognostic factors such as gender age, pTNM (predictive variables) was evaluated in terms of odds ratio statistics. One hundred eighty-three of 227 cases, defined as PCs met the World Health Organization criteria of the not otherwise specified (NOS) (79 cases), microcarcinoma (65 cases), encapsulated (4 cases) and follicular (35 cases) variants. Forty-four cases, defined as pPDCs, met those of the tall cell (39 cases), columnar cell PC (2 cases) and mixed tall cell-columnar cell PC (3 cases) variants. Statistical analyses of the two groups of patients showed a significant correlation between differentiation and age above 40 years, extrathyroid tumor extension and low ratio of regional nodal involvement at the onset of disease. More strikingly they also showed that morphology, ie, a tumoral pattern consistent with pPDC (differentiation), is the strongest predictor of biological behavior including recurrences and recurrence-related deaths that appear to occur five and twenty times more frequently in pPDCs than in PCs, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

  16. Imaging tumors of the patella

    Energy Technology Data Exchange (ETDEWEB)

    Casadei, R., E-mail: roberto.casadei@ior.it [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Kreshak, J., E-mail: j.kreshak@yahoo.com [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy); Rinaldi, R. [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Rimondi, E., E-mail: eugenio.rimondi@ior.it [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Bianchi, G., E-mail: giuseppe.bianchi@ior.it [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Alberghini, M., E-mail: marco.alberghini@ior.it [Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy); Ruggieri, P. [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Vanel, D., E-mail: daniel.vanel@ior.it [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy)

    2013-12-01

    Background: Patellar tumors are rare; only a few series have been described in the literature and radiographic diagnosis can be challenging. We reviewed all patellar tumors at one institution and reviewed the literature. Materials and methods: In an evaluation of the database at one institution from 1916 to 2009, 23,000 bone tumors were found. Of these, 41 involved the patella. All had imaging studies and microscopic diagnostic confirmation. All medical records, imaging studies, and pathology were reviewed. Results: There were 15 females and 26 males, ranging from 8 to 68 years old (average 30). There were 30 benign tumors; eight giant cell tumors, eight chondroblastomas, seven osteoid osteomas, two aneurysmal bone cysts, two ganglions, one each of chondroma, exostosis, and hemangioma. There were 11 malignant tumors: five hemangioendotheliomas, three metastases, one lymphoma, one plasmacytoma, and one angiosarcoma. Conclusion: Patellar tumors are rare and usually benign. As the patella is an apophysis, the most frequent lesions are giant cell tumor in the adult and chondroblastoma in children. Osteoid osteomas were frequent in our series and easily diagnosed. Metastases are the most frequent malignant diagnoses in the literature; in our series malignant vascular tumors were more common. These lesions are often easily analyzed on radiographs. CT and MR define better the cortex, soft tissue extension, and fluid levels. This study presents the imaging patterns of the more common patellar tumors in order to help the radiologist when confronted with a lesion in this location.

  17. Practical molecular pathology and histopathology of embryonal tumors.

    Science.gov (United States)

    Phillips, Joanna; Tihan, Tarik; Fuller, Gregory

    2015-03-01

    There have been significant improvements in understanding of embryonal tumors of the central nervous system (CNS) in recent years. These advances are most likely to influence the diagnostic algorithms and methodology currently proposed by the World Health Organization (WHO) classification scheme. Molecular evidence suggests that the tumors presumed to be specific entities within the CNS/primitive neuroectodermal tumors spectrum are likely to be reclassified. All these developments compel reassessing current status and expectations from the upcoming WHO classification efforts. This review provides a synopsis of current developments and a practical algorithm for the work-up of these tumors in practice.

  18. Unraveling tumor grading and genomic landscape in lung neuroendocrine tumors.

    Science.gov (United States)

    Pelosi, Giuseppe; Papotti, Mauro; Rindi, Guido; Scarpa, Aldo

    2014-06-01

    Currently, grading in lung neuroendocrine tumors (NETs) is inherently defined by the histological classification based on cell features, mitosis count, and necrosis, for which typical carcinoids (TC) are low-grade malignant tumors with long life expectation, atypical carcinoids (AC) intermediate-grade malignant tumors with more aggressive clinical behavior, and large cell NE carcinomas (LCNEC) and small cell lung carcinomas (SCLC) high-grade malignant tumors with dismal prognosis. While Ki-67 antigen labeling index, highlighting the proportion of proliferating tumor cells, has largely been used in digestive NETs for assessing prognosis and assisting therapy decisions, the same marker does not play an established role in the diagnosis, grading, and prognosis of lung NETs. Next generation sequencing techniques (NGS), thanks to their astonishing ability to process in a shorter timeframe up to billions of DNA strands, are radically revolutionizing our approach to diagnosis and therapy of tumors, including lung cancer. When applied to single genes, panels of genes, exome, or the whole genome by using either frozen or paraffin tissues, NGS techniques increase our understanding of cancer, thus realizing the bases of precision medicine. Data are emerging that TC and AC are mainly altered in chromatin remodeling genes, whereas LCNEC and SCLC are also mutated in cell cycle checkpoint and cell differentiation regulators. A common denominator to all lung NETs is a deregulation of cell proliferation, which represents a biological rationale for morphologic (mitoses and necrosis) and molecular (Ki-67 antigen) parameters to successfully serve as predictors of tumor behavior (i.e., identification of pathological entities with clinical correlation). It is envisaged that a novel grading system in lung NETs based on the combined assessment of mitoses, necrosis, and Ki-67 LI may offer a better stratification of prognostic classes, realizing a bridge between molecular alterations

  19. Considering the health care entity C corporation conversion to tax pass-through entity status.

    Science.gov (United States)

    Reilly, Robert F

    2012-01-01

    The double taxation of C corporation income from operations and from the ultimate sale of its assets makes the C corporation an inefficient tax status for many health care entities. At the time of this writing, the changes in the federal tax law that are scheduled to take effect in 2013 will increase this level of double-taxation inefficiency. The owners of a C corporation practice can avoid the C corporation status tax inefficiency by converting the practice to either (1) S corporation status or (2) LLC status. The conversion of the health care C corporation to an S corporation may be accomplished without a current tax cost. However, the conversion of a health care C corporation to an LLC status can result in a current tax at both the corporation level and the shareholder level. Nonetheless, the current conversion tax cost may be less than the future tax cost (1) of operating the practice as a C corporation and incurring double taxation at what may be higher tax rates or (2) of incurring the higher tax cost (or reduced price) on the ultimate disposition of the practice assets and the attendant double taxation of the appreciation in the value of the practice assets. Since individual income tax rates on qualifying dividends from C corporations and on capital gains are currently at very low rates, this may be a good time for C corporation practice owners to consider the costs and benefits of a conversion to either S corporation status or LLC status. The practice owners should consult with their accounting, legal, and valuation advisors in order to consider all of the costs and benefits of a possible corporate tax status conversion. An estimation of both the costs and benefits of the corporate tax status conversion depends on the concluded fair market values of the medical practice, dental practice, or other health care entity assets. And, that practice asset appraisal should encompass all of the practice assets, both tangible assets and intangible assets. PMID

  20. Neuroendocrine Tumors of the Lung

    Energy Technology Data Exchange (ETDEWEB)

    Fisseler-Eckhoff, Annette, E-mail: Annette.Fisseler-Eckhoff@hsk-wiesbaden.de; Demes, Melanie [Department of Pathology und Cytology, Dr. Horst-Schmidt-Kliniken (HSK), Wiesbaden 65199 (Germany)

    2012-07-31

    Neuroendocrine tumors may develop throughout the human body with the majority being found in the gastrointestinal tract and bronchopulmonary system. Neuroendocrine tumors are classified according to the grade of biological aggressiveness (G1–G3) and the extent of differentiation (well-differentiated/poorly-differentiated). The well-differentiated neoplasms comprise typical (G1) and atypical (G2) carcinoids. Large cell neuroendocrine carcinomas as well as small cell carcinomas (G3) are poorly-differentiated. The identification and differentiation of atypical from typical carcinoids or large cell neuroendocrine carcinomas and small cell carcinomas is essential for treatment options and prognosis. Pulmonary neuroendocrine tumors are characterized according to the proportion of necrosis, the mitotic activity, palisading, rosette-like structure, trabecular pattern and organoid nesting. The given information about the histopathological assessment, classification, prognosis, genetic aberration as well as treatment options of pulmonary neuroendocrine tumors are based on own experiences and reviewing the current literature available. Most disagreements among the classification of neuroendocrine tumor entities exist in the identification of typical versus atypical carcinoids, atypical versus large cell neuroendocrine carcinomas and large cell neuroendocrine carcinomas versus small cell carcinomas. Additionally, the classification is restricted in terms of limited specificity of immunohistochemical markers and possible artifacts in small biopsies which can be compressed in cytological specimens. Until now, pulmonary neuroendocrine tumors have been increasing in incidence. As compared to NSCLCs, only little research has been done with respect to new molecular targets as well as improving the classification and differential diagnosis of neuroendocrine tumors of the lung.

  1. Entity versus incremental theories predict older adults' memory performance.

    Science.gov (United States)

    Plaks, Jason E; Chasteen, Alison L

    2013-12-01

    The authors examined whether older adults' implicit theories regarding the modifiability of memory in particular (Studies 1 and 3) and abilities in general (Study 2) would predict memory performance. In Study 1, individual differences in older adults' endorsement of the "entity theory" (a belief that one's ability is fixed) or "incremental theory" (a belief that one's ability is malleable) of memory were measured using a version of the Implicit Theories Measure (Dweck, 1999). Memory performance was assessed with a free-recall task. Results indicated that the higher the endorsement of the incremental theory, the better the free recall. In Study 2, older and younger adults' theories were measured using a more general version of the Implicit Theories Measure that focused on the modifiability of abilities in general. Again, for older adults, the higher the incremental endorsement, the better the free recall. Moreover, as predicted, implicit theories did not predict younger adults' memory performance. In Study 3, participants read mock news articles reporting evidence in favor of either the entity or incremental theory. Those in the incremental condition outperformed those in the entity condition on reading span and free-recall tasks. These effects were mediated by pretask worry such that, for those in the entity condition, higher worry was associated with lower performance. Taken together, these studies suggest that variation in entity versus incremental endorsement represents a key predictor of older adults' memory performance.

  2. Quality of the Accounting Information of Brazilian Third Sector Entities

    Directory of Open Access Journals (Sweden)

    Fernando Maciel Ramos

    2015-08-01

    Full Text Available In this study, the objective was to analyze the quality of accounting information of Brazilian non-profit organizations. As for the objective the research is characterized as a descriptive one; as for the research strategy it is documental and as for the approach it is quantitative. In order to measure the quality of the accounting information of the analyzed entities, it was prepared a checklist starting from the accounting rules that guide the accounting practice of the third sector entities made up of seven sections and 59 requisites, which enabled the construction of the Quality Index for Accounting Information. The data were analyzed through descriptive statistics (minimum, maximum, mean, standard deviation and the results indicated a low level of the accounting information quality reported by the analyzed entities, especially when compared to for-profit organizations. One comes to the conclusion, based on the findings, that the analyzed entities present a low level of quality as to the accounting information which may jeopardize the information usefulness reported by these entities users. 

  3. Orbit-associated tumors: navigation and control of resection using intraoperative computed tomography.

    Science.gov (United States)

    Terpolilli, Nicole A; Rachinger, Walter; Kunz, Mathias; Thon, Niklas; Flatz, Wilhelm H; Tonn, Jörg-Christian; Schichor, Christian

    2016-05-01

    OBJECT Treatment of skull base lesions is complex and usually requires a multidisciplinary approach. In meningioma, which is the most common tumor entity in this region, resection is considered to be the most important therapeutic step to avoid tumor recurrence. However, resection of skull base lesions with orbital or optic nerve involvement poses a challenge due to their anatomical structure and their proximity to eloquent areas. Therefore the main goal of surgery should be to achieve the maximum extent of resection while preserving neurological function. In the postoperative course, medical and radiotherapeutic strategies may then be successfully used to treat possible tumor residues. Methods to safely improve the extent of resection in skull base lesions therefore are desirable. The current study reports the authors' experience with the use of intraoperative CT (iCT) combined with neuronavigation with regard to feasibility and possible benefits of the method. METHODS Those patients with tumorous lesions in relationship to the orbit, sphenoid wing, or cavernous sinus who were surgically treated between October 2008 and December 2013 using iCT-based neuronavigation and in whom an intraoperative scan was obtained for control of resection were included. In all cases a second iCT scan was performed under sterile conditions after completion of navigation-guided microsurgical tumor resection. The surgical strategy was adapted accordingly; if necessary, resection was continued. RESULTS Twenty-three patients (19 with WHO Grade I meningioma and 4 with other lesions) were included. The most common clinical symptoms were loss of visual acuity and exophthalmus. Intraoperative control of resection by iCT was successfully obtained in all cases. Intraoperative imaging changed the surgical approach in more than half (52.2%) of these patients, either because iCT demonstrated unexpected residual tumor masses or because the second scan revealed additional tumor tissue that was not

  4. Endoscopic resection of subepithelial tumors

    OpenAIRE

    Schmidt, Arthur; Bauder, Markus; Riecken, Bettina; Caca, Karel

    2014-01-01

    Management of subepithelial tumors (SETs) remains challenging. Endoscopic ultrasound (EUS) has improved differential diagnosis of these tumors but a definitive diagnosis on EUS findings alone can be achieved in the minority of cases. Complete endoscopic resection may provide a reasonable approach for tissue acquisition and may also be therapeutic in case of malignant lesions. Small SET restricted to the submucosa can be removed with established basic resection techniques. However, resection o...

  5. Dysembryoplastic neuroepithelial tumor: A rare brain tumor not to be misdiagnosed.

    Science.gov (United States)

    Sukheeja, Deepti; Mehta, Jayanti

    2016-01-01

    Dysembryoplastic neuroepithelial tumor (DNET) is a recently described, morphologically unique, and surgically curable low-grade brain tumor which is included in the latest WHO classification as neuronal and mixed neuronal-glial tumor. It is usually seen in children and young adults. The importance of this particular entity is that it is a surgically curable neuroepithelial neoplasm. When recognized, the need for adjuvant radiotherapy and chemotherapy is obviated. We hereby present a case report of an 8-year-old male child who presented with intractable seizures and parieto-occipital space occupying lesion. Histologically, the tumor exhibited features of WHO grade I dysembryoplastic neuroepithelial tumor which was further confirmed by immunohistochemistry. PMID:27057233

  6. Inflammatory Myofibroblastic Tumor of the Right Atrium

    Directory of Open Access Journals (Sweden)

    Neerod K. Jha

    2010-01-01

    Full Text Available Cardiac inflammatory myofibroblastic tumor (IMT is a rare entity and is associated with distinct clinical, pathological and molecular features. The clinical behavior, natural history, biological potential, management and prognosis of such tumors are unclear. We present herewith an adolescent girl who presented with similar entity involving the junction of the right atrium and the inferior vena cava (IVC in association with thrombocytosis and IVC thrombosis leading to obstruction of blood flow. Diagnostic tools included imaging and immuno-histopathology studies. Surgical management included resection of the tumor and thrombo-embolectomy of the IVC under cardiopulmonary bypass. This case is unique due to association of complete obstruction of IVC caused by the strategic location of the tumor, thrombosis of vena cava and association of thrombocytosis. These features have not been reported yet in relation to the cardiac IMT. This report will help in better understanding and management of similar cases in terms of planning cannulation of femoral veins or application of total hypothermic circulatory arrest during cardiopulmonary bypass and prompt us to look for recurrence or metastasis during follow up using echocardiography and laboratory investigations. The possibility of IMT should be kept in the differential diagnosis of cardiac tumors especially in children and adolescents.

  7. Mining heart disease risk factors in clinical text with named entity recognition and distributional semantic models.

    Science.gov (United States)

    Urbain, Jay

    2015-12-01

    We present the design, and analyze the performance of a multi-stage natural language processing system employing named entity recognition, Bayesian statistics, and rule logic to identify and characterize heart disease risk factor events in diabetic patients over time. The system was originally developed for the 2014 i2b2 Challenges in Natural Language in Clinical Data. The system's strengths included a high level of accuracy for identifying named entities associated with heart disease risk factor events. The system's primary weakness was due to inaccuracies when characterizing the attributes of some events. For example, determining the relative time of an event with respect to the record date, whether an event is attributable to the patient's history or the patient's family history, and differentiating between current and prior smoking status. We believe these inaccuracies were due in large part to the lack of an effective approach for integrating context into our event detection model. To address these inaccuracies, we explore the addition of a distributional semantic model for characterizing contextual evidence of heart disease risk factor events. Using this semantic model, we raise our initial 2014 i2b2 Challenges in Natural Language of Clinical data F1 score of 0.838 to 0.890 and increased precision by 10.3% without use of any lexicons that might bias our results.

  8. Pott′s puffy tumor following an insect bite

    Directory of Open Access Journals (Sweden)

    Raja V

    2007-01-01

    Full Text Available Pott′s puffy tumor, a feature of osteomyelitis of the frontal bone, is a rare entity, especially in adults. Sir Percival Pott originally described this condition as a complication of trauma to the frontal bone. This is also a recognized complication of fronto-ethmoidal sinusitis. We present a rare case of Pott′s puffy tumor caused by an insect bite presenting initially as a preseptal cellulitis and explore its pathogenesis and management.

  9. A curious discourse of Krukenberg tumor: a case report

    Science.gov (United States)

    Sahu, Diwakar; Wani, Majid; Reddy, Prasanna Kumar

    2014-01-01

    Krukenberg tumor is usually but not always a bilateral involvement of ovaries from metastatic deposit from adenocarcinoma of stomach and rarely from other gastrointestinal (GI) and non GI organs. The route of metastatsis of this rare condition is still not proven. It is still uncertain whether surgical resection of ovarian metastases and/or primary tumor could improve the outcome. We report even a rare presentation of this rare disease entity. PMID:25436134

  10. Wilms tumor arising in extracoelomic paravertebral soft tissues.

    LENUS (Irish Health Repository)

    Mulligan, Linda

    2012-02-01

    Extrarenal Wilms tumor (ERWT) is a well-established entity which most commonly arises within the genitourinary tract, including intracoelomic paranephric soft tissue. Rarely, ERWT arises within teratoma, and it tends to occur predominantly in distinct settings, such as females with spinal defects and males with testicular teratomas. We report a unique ERWT arising within an extracoelomic teratoma of the paraspinal musculature, thereby expanding the range of reported locations for this unusual tumor.

  11. BRONCO: Biomedical entity Relation ONcology COrpus for extracting gene-variant-disease-drug relations.

    Science.gov (United States)

    Lee, Kyubum; Lee, Sunwon; Park, Sungjoon; Kim, Sunkyu; Kim, Suhkyung; Choi, Kwanghun; Tan, Aik Choon; Kang, Jaewoo

    2016-01-01

    Comprehensive knowledge of genomic variants in a biological context is key for precision medicine. As next-generation sequencing technologies improve, the amount of literature containing genomic variant data, such as new functions or related phenotypes, rapidly increases. Because numerous articles are published every day, it is almost impossible to manually curate all the variant information from the literature. Many researchers focus on creating an improved automated biomedical natural language processing (BioNLP) method that extracts useful variants and their functional information from the literature. However, there is no gold-standard data set that contains texts annotated with variants and their related functions. To overcome these limitations, we introduce a Biomedical entity Relation ONcology COrpus (BRONCO) that contains more than 400 variants and their relations with genes, diseases, drugs and cell lines in the context of cancer and anti-tumor drug screening research. The variants and their relations were manually extracted from 108 full-text articles. BRONCO can be utilized to evaluate and train new methods used for extracting biomedical entity relations from full-text publications, and thus be a valuable resource to the biomedical text mining research community. Using BRONCO, we quantitatively and qualitatively evaluated the performance of three state-of-the-art BioNLP methods. We also identified their shortcomings, and suggested remedies for each method. We implemented post-processing modules for the three BioNLP methods, which improved their performance.Database URL:http://infos.korea.ac.kr/bronco. PMID:27074804

  12. Integrated Machine Learning Techniques for Arabic Named Entity Recognition

    Directory of Open Access Journals (Sweden)

    Samir AbdelRahman

    2010-07-01

    Full Text Available Named Entity Recognition (NER task has become essential to improve the performance of many NLP tasks. Its aim is to endeavor a solution to boost accurately the identification of extracted named entities. This paper presents a novel solution for Arabic Named Entity Recognition (ANER problem. The solution is an integration approach between two machine learning techniques, namely bootstrapping semi-supervised pattern recognition and Conditional Random Fields (CRF classifier as a supervised technique. The paper solution contributions are the exploit of pattern and word semantic fields as CRF features, the adventure of utilizing bootstrapping semisupervised pattern recognition technique in Arabic Language, and the integration success to improve the performance of its components. Moreover, as per to our knowledge, this proposed integration has not been utilized for NER task of other natural languages. Using 6-fold cross-validation experimental tests, the solution is proved that it outperforms previous CRF sole work and LingPipe tool.

  13. Load Balancing for MapReduce-based Entity Resolution

    CERN Document Server

    Kolb, Lars; Rahm, Erhard

    2011-01-01

    The effectiveness and scalability of MapReduce-based implementations of complex data-intensive tasks depend on an even redistribution of data between map and reduce tasks. In the presence of skewed data, sophisticated redistribution approaches thus become necessary to achieve load balancing among all reduce tasks to be executed in parallel. For the complex problem of entity resolution, we propose and evaluate two approaches for such skew handling and load balancing. The approaches support blocking techniques to reduce the search space of entity resolution, utilize a preprocessing MapReduce job to analyze the data distribution, and distribute the entities of large blocks among multiple reduce tasks. The evaluation on a real cloud infrastructure shows the value and effectiveness of the proposed load balancing approaches.

  14. Enhanced Named Entity Extraction via Error-Driven Aggregation

    Energy Technology Data Exchange (ETDEWEB)

    Lemmond, T D; Perry, N C; Guensche, J W; Nitao, J J; Glaser, R E; Kidwell, P; Hanley, W G

    2010-02-22

    Despite recent advances in named entity extraction technologies, state-of-the-art extraction tools achieve insufficient accuracy rates for practical use in many operational settings. However, they are not generally prone to the same types of error, suggesting that substantial improvements may be achieved via appropriate combinations of existing tools, provided their behavior can be accurately characterized and quantified. In this paper, we present an inference methodology for the aggregation of named entity extraction technologies that is founded upon a black-box analysis of their respective error processes. This method has been shown to produce statistically significant improvements in extraction relative to standard performance metrics and to mitigate the weak performance of entity extractors operating under suboptimal conditions. Moreover, this approach provides a framework for quantifying uncertainty and has demonstrated the ability to reconstruct the truth when majority voting fails.

  15. A CONDITIONAL RANDOM FIELDS APPROACH TO BIOMEDICAL NAMED ENTITY RECOGNITION

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Named entity recognition is a fundamental task in biomedical data mining. In this letter, a named entity recognition system based on CRFs (Conditional Random Fields) for biomedical texts is presented. The system makes extensive use of a diverse set of features, including local features, full text features and external resource features. All features incorporated in this system are described in detail,and the impacts of different feature sets on the performance of the system are evaluated. In order to improve the performance of system, post-processing modules are exploited to deal with the abbreviation phenomena, cascaded named entity and boundary errors identification. Evaluation on this system proved that the feature selection has important impact on the system performance, and the post-processing explored has an important contribution on system performance to achieve better results.

  16. PERFORMANCE ANALYSIS OF AN ENTITY FROM CONSTRUCTION SECTOR USING DASHBOARD

    Directory of Open Access Journals (Sweden)

    SORIN BRICIU

    2015-12-01

    Full Text Available This research paper deals with the analysis of performances of economic entities from the construction sector from Romania. The necessary data for preparation and analysis up through dashboard of the economic entity are provided by managerial accounting through Target Costing method. The way of implementing and observing of stages which are completed in managerial accounting through Target Costing method are also presented in the paper based on the existing literature. For data analysis it was used a questionnaire based on three questions whose results were analyzed and which formed the basis of our entire course of scientific approach. The paper ends with the authors' conclusions about the performance analysis of economic entities in a construction project using dashboard showing the benefits of its long-term decisions.

  17. Network analysis of named entity interactions in written texts

    CERN Document Server

    Amancio, Diego R

    2015-01-01

    The use of methods borrowed from statistics and physics has allowed for the discovery of unprecedent patterns of human behavior and cognition by establishing links between models features and language structure. While current models have been useful to identify patterns via analysis of syntactical and semantical networks, only a few works have probed the relevance of investigating the structure arising from the relationship between relevant entities such as characters, locations and organizations. In this study, we introduce a model that links entities appearing in the same context in order to capture the complexity of entities organization through a networked representation. Computational simulations in books revealed that the proposed model displays interesting topological features, such as short typical shortest path length, high values of clustering coefficient and modular organization. The effectiveness of the our model was verified in a practical pattern recognition task in real networks. When compared ...

  18. Using Local Grammar for Entity Extraction from Clinical Reports

    Directory of Open Access Journals (Sweden)

    Aicha Ghoulam

    2015-06-01

    Full Text Available Information Extraction (IE is a natural language processing (NLP task whose aim is to analyze texts written in natural language to extract structured and useful information such as named entities and semantic relations linking these entities. Information extraction is an important task for many applications such as bio-medical literature mining, customer care, community websites, and personal information management. The increasing information available in patient clinical reports is difficult to access. As it is often in an unstructured text form, doctors need tools to enable them access to this information and the ability to search it. Hence, a system for extracting this information in a structured form can benefits healthcare professionals. The work presented in this paper uses a local grammar approach to extract medical named entities from French patient clinical reports. Experimental results show that the proposed approach achieved an F-Measure of 90. 06%.

  19. A Rare Case of Mixed Neuroendocrine Tumor and Adenocarcinoma of the Pancreas.

    Science.gov (United States)

    Xenaki, Sofia; Lasithiotakis, Konstantinos; Andreou, Alexandros; Aggelaki, Sofia; Tzardi, Maria; Daskalaki, Anna; Chalkiadakis, George; Chrysos, Emmanuel

    2016-01-01

    Introduction. Neuroendocrine carcinoma (NEC) of pancreas is a rare tumor with aggressive progression and poor prognosis. Its coexistence with adenocarcinoma poses significant clinical problems and has not been addressed in the literature. Methods. We describe a case of a 51-year-old male who underwent pancreatoduodenectomy due to pancreatic head tumor 1.5 × 1 × 1.4 cm. Histological examination of the specimen revealed a mixed neoplasm: (1) a well differentiated adenocarcinoma, neoplastic blasts of which are extended focally to the submucosa without invading the muscular layer, and (2) a low differentiated NEC consisting of solid clusters and pagetoid formations. All 18 lymph nodes of the specimen were free of neoplastic disease and the surgical margins of the specimen were tumor-free. No adjuvant treatment was administered and two months after the operation the patient developed liver metastasis. FNA cytology of the hepatic lesions revealed low grade carcinoma with neuroendocrine characteristics. Five lines of chemotherapy were administered: VP + CDDP, paclitaxel + ifosfamide + Mesna + CDDP, Folfox + Avastin, Folfiri + Avastin, and CAV. During his treatment he revealed PD and succumbed to his disease 13 months after the operation. Conclusion. Coexistence of NEC with adenocarcinoma of the pancreas is a very rare entity presenting significant challenges regarding its adjuvant treatment and the treatment of distant relapse. PMID:27610261

  20. Advances in managing medulloblastoma and intracranial primitive neuro-ectodermal tumors.

    Science.gov (United States)

    Adamski, Jenny; Ramaswamy, Vijay; Huang, Annie; Bouffet, Eric

    2014-01-01

    Medulloblastoma and central nervous system (CNS)-primitive neuro-ectodermal tumors (PNETs) are a diverse group of entities which encompasses different pathological and clinical pictures. Initially divided based on histology and location, molecular insight is leading to new definitions and a change in the borders delineating these diseases, such that they become more divergent. Current treatment approaches consist of surgical resection, radiotherapy and intensive chemotherapy, dependent on age. Stratification is one risk factor shown to be prognostic and is divided into high- and average-risks. Outcomes with modern treatment regimens are good, particularly in average-risk medulloblastoma patients, but the cost of cure is high, with high rates of neurocognitive, endocrine and social dysfunction. The changing biological landscape, however, may allow for clearer prediction of tumor behavior, to better identify "good" and "bad" players within these groups. Discovery of subgroups with changes in dependent molecular pathways will also lead to the development of new specific targeted therapies. Presenting exciting opportunities, these advances may transform the treatment for some patients, revolutionizing therapy in the future. Several challenges, however, are yet to be faced and caution is needed not to abandon previously defined prognostic factors on the strength of thus far retrospective evidence. We are witnessing a new era of trials with biological stratification involving multiple subgroups and treatment arms, based on specific tumor-related targets. This review discusses the changing face of medulloblastoma and CNS-PNETs and how we move molecular advances into clinical trials that benefit patients. PMID:25184046

  1. Primary vaginal non-Hodgkin’s lymphoma: report of a rare clinical entity

    Directory of Open Access Journals (Sweden)

    Vera Silva

    2015-12-01

    Full Text Available A 52-year-old woman was referred to the gynecology outpatient clinic with a 2 months history of vaginal bleeding with intercourse, and no other symptoms. Vaginal examination revealed a firm, non-tender, mass in the posterior vaginal wall. The initial clinical impression was that of a vaginal carcinoma and a biopsy under local anesthesia was performed, but the result was inconclusive. A deeper biopsy, under general anesthesia, was performed and a histological diagnosis of non-Hodgkin’s lymphoma was done. The staging workup permitted to exclude any other site of the body affected by the malignancy. Hematologists reviewed the patient and recommended chemotherapy. A complete tumor regression was observed and the patient has now a disease-free survival of 72 months. This case report intends to create awareness of this rare clinical entity. Although the gynecologist will rarely be faced to extranodal lymphoma, it should be included in the differential diagnosis of gynecologic malignancies.

  2. Malignant struma ovarii: a rare oncologic entity; Struma ovarii maligno: uma rara entidade oncologica

    Energy Technology Data Exchange (ETDEWEB)

    Barbosa, Frederico Paes; Mendonca, Sandro Bichara [Clinica Santa Maria, Campos dos Goytacazes, RJ (Brazil). Inst. de Oncologia; Gomes Filho, Firmino de Azevedo; Antunes, Flavio; Soares, Thelia Maria dos Santos [Instituto de Oncologia de Macae, RJ (Brazil); Souza, Thiago Ferreira de [Santa Casa de Misericordia, Sao Paulo, SP (Brazil). Servico de Cirurgia Geral

    2004-07-01

    Struma ovarii (SO) malignant is a rare ovarian teratoid tumor, consisting predominantly of thyroid tissue. It has low incidence and a few cases described by the literature. Usually appears in the 4th or 5th decade of life. Generally they are diagnosed after surgery, being the diagnostic reserved for the lesions on the ectopic thyroid tissue based on cellular atypia, mitotic activity, capsular invasion and metastases. Due to its rarity,it does not still have a consensus about the best therapeutical management and protocol of accompaniment for patients with this neoplastic entity. This article reports a case of a patient with malignant S O, reviewing the relevant aspects of the literature. (author)

  3. Business Environment and Corporate Governance in Public Entities

    Directory of Open Access Journals (Sweden)

    Eugen Nicolaescu

    2012-12-01

    Full Text Available For several years, private business has adopted corporative governance on the grounds of national and international codes to enhance investor confidence in companies and economic entities, especially those that are listed on the stock exchanges. The business environment for the public sector has not benefited from corporate governance due to certain bureaucratic, but logical reasons, such as the fact that the representatives of the State/Government/local authority apply the shareholder’s decisions without considering any other principles, procedures or rules reflecting the organization and the operation of the public entity. Economic and social reality has shown that many public entities have been confronting with different issues in making managerial decisions and obeying managerial principles of neutrality when appointing directors or establishing their remuneration, without prejudice to the objectives of those entities, many of them with losses and arrears that could generate bankruptcy to a private entity. More in-depth relations of Romania with the European Union and international financial organizations have imposed the importance of the corporate governance in public sector business environment as well, which the Government settled with the adoption of specific legal rules. A general appreciation implies that the decisions made are important, but entirely efficient, many of them being simple statements without concrete effects on the organization and the improvement of managerial work. Consequently, certain corrections are expected and a series of future developments of corporate governance aspects should be examined in private business. The codes of corporate governance in the private sector should be taken as such and as for the public economic environment, additional provisions relating to the applicability of public patrimony administration should be considered while recognising the specific characteristics of each economic entity

  4. Hyperuricemic Renal Failure in Nonhematologic Solid Tumors: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Neeraj Saini

    2012-01-01

    Full Text Available Tumor lysis syndrome (TLS is an oncologic emergency that is caused by massive tumor cell lysis. It is commonly associated with hematological cancers like leukemia and lymphoma and uncommonly with solid nonhematologic tumors as well. However, spontaneous tumor lysis syndrome (STLS without any cytotoxic chemotherapy rarely occurs in solid tumors. We describe a case of STLS in a metastatic adenocarcinoma of unknown primary and review the literature of STLS in solid non-hematologic tumors to identify various risk factors for pathogenesis of this entity.

  5. Spatio-structural granularity of biological material entities

    Directory of Open Access Journals (Sweden)

    Vogt Lars

    2010-05-01

    Full Text Available Abstract Background With the continuously increasing demands on knowledge- and data-management that databases have to meet, ontologies and the theories of granularity they use become more and more important. Unfortunately, currently used theories and schemes of granularity unnecessarily limit the performance of ontologies due to two shortcomings: (i they do not allow the integration of multiple granularity perspectives into one granularity framework; (ii they are not applicable to cumulative-constitutively organized material entities, which cover most of the biomedical material entities. Results The above mentioned shortcomings are responsible for the major inconsistencies in currently used spatio-structural granularity schemes. By using the Basic Formal Ontology (BFO as a top-level ontology and Keet's general theory of granularity, a granularity framework is presented that is applicable to cumulative-constitutively organized material entities. It provides a scheme for granulating complex material entities into their constitutive and regional parts by integrating various compositional and spatial granularity perspectives. Within a scale dependent resolution perspective, it even allows distinguishing different types of representations of the same material entity. Within other scale dependent perspectives, which are based on specific types of measurements (e.g. weight, volume, etc., the possibility of organizing instances of material entities independent of their parthood relations and only according to increasing measures is provided as well. All granularity perspectives are connected to one another through overcrossing granularity levels, together forming an integrated whole that uses the compositional object perspective as an integrating backbone. This granularity framework allows to consistently assign structural granularity values to all different types of material entities. Conclusions The here presented framework provides a spatio

  6. Ossification of the bilateral Achilles tendon: a rare entity

    International Nuclear Information System (INIS)

    Ossification of the Achilles tendon is a rare clinical entity comprising of one or more segments of variable sized ossified masses in the fibrocartilaginous substance of the tendon. The etiology of ossification of the Achilles tendon is multifactorial with recurrent trauma and surgery comprising major predisposing factors, with others being metabolic, systemic, and infectious diseases. The possibility of a genetic predisposition towards this entity has also been raised, but has not yet been proven. We present a rare case of ossification of the bilateral Achilles tendons without any history of trauma or surgery in a 48-year-old female patient

  7. The sky entities as represented in African literature

    Science.gov (United States)

    Urama, Evelyn N.

    2011-06-01

    Astronomical observations used by the ancient people of Africa were developed out of the people's desire to have concrete manifestations of their gods and religious beliefs as well as for time-keeping - day, night and calendar for agricultural and festive seasons. The sky entities (the solar and stellar systems) observed become part of the lives and events here on Earth and so are also part of the context of African literature. This paper examines the ways in which different African peoples have reflected on the role of the sky entities in their literature.

  8. Detection of Unauthorized Human Entity in Surveillance Video

    Directory of Open Access Journals (Sweden)

    D Radha

    2013-06-01

    Full Text Available With the ever growing need for video surveillance in various fields, it has become very important to automate the entire process in order to save time, cost and achieve accuracy. In this paper we propose a novel and rapid approach to detect unauthorized human entity for the video surveillance system. The approach is based on bottom-up visual attention model using extended Itti Koch saliency model. Our approach includes three modules- Key frame extraction module, Visual attention model module, Human detection module. This approach permits detection and separation of the unauthorized human entity with higher accuracy than the existing Itti Koch saliency model.

  9. Delivery Challenges for Fluoride, Chlorhexidine and Xylitol

    OpenAIRE

    Featherstone, John DB

    2006-01-01

    The progression or reversal of dental caries is determined by the balance between pathological and protective factors. It is well established that a) fluoride inhibits demineralization and enhances remineralization, b) chlorhexidine reduces the cariogenic bacterial challenge, and c) xylitol is non-cariogenic and has antibacterial properties. The challenge that we face is how best to deliver these anti-caries entities at true therapeutic levels, over time, to favorably tip the caries balance. ...

  10. Ovarian Metastasis from Lung Cancer: A Rare Entity

    Directory of Open Access Journals (Sweden)

    Huseyin Cengiz

    2013-01-01

    Full Text Available This paper describes a case of ovarian metastasis from lung carcinoma along with its diagnostic challenges, clinical management, and review of the literature. A 49-year-old woman was admitted to our emergency department with complaints of abdominal pain and vomiting. A laparoscopic appendectomy was performed due to acute appendicitis, and a unilateral oophorectomy (left side via laparoscopy was performed due to the detection of an ovarian mass. Immunohistochemical staining of the ovarian mass revealed that it was reactive to cytokeratin-7 (CK-7 but negative for CK-20. The immunohistochemical and pathological features of the tumor indicated an ovarian metastasis of non-small-cell lung cancer. The patient underwent chemotherapy and was followed up by the oncology department. Her postoperative regular followup of 6 months showed that her condition was stable with no recurrence. The management of female patients with acute abdominal pain and pelvic masses should consist of a multidisciplinary approach to include the diagnosis of any distant organ metastasis.

  11. EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue : a case report

    NARCIS (Netherlands)

    Flucke, Uta; Mentzel, Thomas; Verdijk, Marian A.; Slootweg, Pieter J.; Creytens, David H.; Suurmeijer, Albert J. H.; Tops, Bastiaan B. J.

    2012-01-01

    Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we des

  12. EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report.

    NARCIS (Netherlands)

    Flucke, U.; Mentzel, T.; Verdijk, M.A.J.; Slootweg, P.J.; Creytens, D.H.; Suurmeijer, A.J.H.; Tops, B.B.J.

    2012-01-01

    Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we des

  13. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.

    Science.gov (United States)

    Louis, David N; Perry, Arie; Reifenberger, Guido; von Deimling, Andreas; Figarella-Branger, Dominique; Cavenee, Webster K; Ohgaki, Hiroko; Wiestler, Otmar D; Kleihues, Paul; Ellison, David W

    2016-06-01

    The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor. For the first time, the WHO classification of CNS tumors uses molecular parameters in addition to histology to define many tumor entities, thus formulating a concept for how CNS tumor diagnoses should be structured in the molecular era. As such, the 2016 CNS WHO presents major restructuring of the diffuse gliomas, medulloblastomas and other embryonal tumors, and incorporates new entities that are defined by both histology and molecular features, including glioblastoma, IDH-wildtype and glioblastoma, IDH-mutant; diffuse midline glioma, H3 K27M-mutant; RELA fusion-positive ependymoma; medulloblastoma, WNT-activated and medulloblastoma, SHH-activated; and embryonal tumour with multilayered rosettes, C19MC-altered. The 2016 edition has added newly recognized neoplasms, and has deleted some entities, variants and patterns that no longer have diagnostic and/or biological relevance. Other notable changes include the addition of brain invasion as a criterion for atypical meningioma and the introduction of a soft tissue-type grading system for the now combined entity of solitary fibrous tumor / hemangiopericytoma-a departure from the manner by which other CNS tumors are graded. Overall, it is hoped that the 2016 CNS WHO will facilitate clinical, experimental and epidemiological studies that will lead to improvements in the lives of patients with brain tumors. PMID:27157931

  14. Malignant Peripheral Nerve Sheath Tumor: MRI and CT Findings

    Directory of Open Access Journals (Sweden)

    K. O. Kragha

    2015-01-01

    important in its diagnosis. A rare case of MPNST that produced urinary retention and bowel incontinence is presented that may aid clinicians in the diagnosis of this rare clinical entity. Motor weakness, central enhancement, and immunohistochemistry may assist in the diagnosis of MPNST and differentiation between benign peripheral nerve sheath tumor (BPNST and MPNST.

  15. Placental site trophoblastic tumor in a late recurrence of a nonseminomatous germ cell tumor of the testis

    NARCIS (Netherlands)

    Suurmeijer, AJH; Gietema, JA; Hoekstra, HJ

    2004-01-01

    Placental site trophoblastic tumor (PSTT) is a well-defined entity in the female genital tract. In the male genital tract, a single case of PSTT in the testis of a young boy has been reported. Despite its very rare occurrence, PSTT of the testis has been incorporated in the latest WHO classification

  16. Imaging of brain tumors

    International Nuclear Information System (INIS)

    The contents are diagnostic approaches, general features of tumors -hydrocephalus, edema, attenuation and/or intensity value, hemorrhage, fat, contrast enhancement, intra-axial supratentorial tumors - tumors of glial origin, oligodendrogliomas, ependymomas, subependymomas, subependymal giant cell astrocytomas, choroid plexus papilloma; midline tumors - colloid cysts, craniopharyngiomas; pineal region tumors and miscellaneous tumors i.e. primary intracerebral lymphoma, primitive neuroectodermal tumors, hemangioblastomas; extraaxial tumors - meningiomas; nerve sheath tumors -schwannomas, epidermoids, dermoids, lipomas, arachnoid cysts; metastatic tumors (8 refs.)

  17. Business Entity Selection: Why It Matters to Healthcare Practitioners. Part II--Corporations, Limited Liability Companies, and Professional Entities.

    Science.gov (United States)

    Nithman, Robert W

    2015-01-01

    The Bureau of Labor statistics indicates only a 50% four-year survivability rate among businesses classified as "education and health services." Gaining knowledge of IRS business entities can result in cost savings, operational efficiency, reduced liability, and enhanced sustainability. Each entity has unique disadvantages, depending on size, diversity of ownership, desire to expand, and profitability. Business structures should be compatible with organizational mission or vision statements, services and products, and professional codes of ethics. Healthcare reform will require greater business acumen. We have an ethical duty to disseminate and acquire the knowledge to properly establish and manage healthcare practices to ensure sustainable services that protect and serve the community. PMID:26182701

  18. Business Entity Selection: Why It Matters to Healthcare Practitioners. Part II--Corporations, Limited Liability Companies, and Professional Entities.

    Science.gov (United States)

    Nithman, Robert W

    2015-01-01

    The Bureau of Labor statistics indicates only a 50% four-year survivability rate among businesses classified as "education and health services." Gaining knowledge of IRS business entities can result in cost savings, operational efficiency, reduced liability, and enhanced sustainability. Each entity has unique disadvantages, depending on size, diversity of ownership, desire to expand, and profitability. Business structures should be compatible with organizational mission or vision statements, services and products, and professional codes of ethics. Healthcare reform will require greater business acumen. We have an ethical duty to disseminate and acquire the knowledge to properly establish and manage healthcare practices to ensure sustainable services that protect and serve the community.

  19. Updates on the diagnosis and treatment of intracranial nerve malignant peripheral nerve sheath tumors

    Directory of Open Access Journals (Sweden)

    L'Heureux-Lebeau B

    2013-04-01

    Full Text Available Bénédicte L'Heureux-Lebeau,1 Issam Saliba2 1University of Montreal, 2Department of Otolaryngology Head and Neck Surgery, Montreal University Hospital Center (CHUM, University of Montreal, Montreal, Quebec, Canada Background: Malignant peripheral nerve sheath tumors (MPNSTs are rare entities and MPNSTs of intracranial nerves are even more sporadic. MPNSTs present diagnosis and treatment challenges since there are no defined diagnosis criteria and no established therapeutic strategies. Methods: We reviewed literature for MPNST-related articles. We found 45 relevant studies in which 60 cases were described. Results: We identified 60 cases of intracranial nerve MPNSTs. The age ranged from 3 to 75 years old. Male to female ratio was 1.5:1. The most involved cranial nerves (CNs were CN VIII (60%, CN V (27%, and CN VII (10%. Most of the MPNSTs reported (47% arose sporadically, 40% arose from a schwannoma, 8% arose from a neurofibroma, and 6% arose from an unspecified nerve tumor. Twenty patients had a history of radiation exposure, four patients had neurofibromatosis type 1 (NF1, four patients had neurofibromatosis type 2 (NF2, and NF2 was suspected in two other patients. Twenty-two patients were treated with radiotherapy and presented a higher survival rate. Seventy-two percent of patients died of their disease while 28% of patients survived. One-year survival rate was 33%. Forty-five percent of tumors recurred and 19% of patients had metastases. Conclusion: MPNSTs involving CNs are very rare. Diagnosis is made in regards to the histological and pathological findings. Imaging may help orient the diagnosis. A preexisting knowledge of the clinical situation is more likely to lead to a correct diagnosis. The mainstay of treatment is radical surgical resection with adjuvant radiotherapy. Since these tumors are associated with a poor prognosis, a close follow-up is mandatory. Keywords: malignant peripheral nerve sheath tumor, MPNST, neurofibroma

  20. Web Entities Extraction Based on Semi-Structured Semantic Database

    Directory of Open Access Journals (Sweden)

    Fang Dong

    2013-07-01

    Full Text Available Web is the biggest source of information and contains many entities and relationships between them, extracting these data from Massive Web pages and Integrating to a Semi-Structured Data with rich semantics will be more conducive to the management and use of these web data. On this premise, a comprehensive method is proposed to perform extraction the entities and relationships from the webpages. The method consists of two steps: 1 The target Web pages which contains these entities will be found based on the combination of vision information and content of keyword, meanwhile recording the relationship between father and children target Web pages; 2 Extracting the entities with analysis of DOM tree structure of the obtained Web pages and definitions of some extraction rules. At last, the extracted data is organized into a Semi-Structured Data with special relationships. Experiments on a large number of HTML pages have showed that this method can get a high correct rate and coverage.

  1. 77 FR 66566 - Stress Testing of Regulated Entities

    Science.gov (United States)

    2012-11-06

    ..., FHFA published for comment in the Federal Register a proposed rule, and invited comments. See 77 FR...; ] FEDERAL HOUSING FINANCE AGENCY 12 CFR Part 1238 RIN 2590-AA47 Stress Testing of Regulated Entities AGENCY... notice of proposed rulemaking for public comment concerning stress testing of the Federal...

  2. Amelogenesis imperfecta and localised aggressive periodontitis: A rare clinical entity

    Directory of Open Access Journals (Sweden)

    Gayatri Gundannavar

    2013-01-01

    Full Text Available This case report presents two female patients whose chief complaint was discoloration of teeth. On careful clinical examination it was found that the patients had features of amelogenesis imperfecta and localised aggressive periodontitis. This article will give an insight of clinical and radiographic features of amelogenesis imperfecta with localised aggressive periodontitis, which is a rare clinical entity.

  3. PRIMARY OMENTAL HYDATID CYST – A RARE ENTITY

    Directory of Open Access Journals (Sweden)

    Prashant M

    2015-08-01

    Full Text Available Hydatid cyst is caused by the parasite Echinococcus granulosus ( L arval form in humans with lesions most frequently encountered in the liver and lungs. It can rarely involve extra - hepatic organs. Primary omental hydatid cyst is rare entity. This report presents the interesting case of a very large primary omental hydatid cyst.

  4. 37 CFR 381.2 - Definition of public broadcasting entity.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Definition of public... OF CONGRESS RATES AND TERMS FOR STATUTORY LICENSES USE OF CERTAIN COPYRIGHTED WORKS IN CONNECTION WITH NONCOMMERCIAL EDUCATIONAL BROADCASTING § 381.2 Definition of public broadcasting entity. As...

  5. Contained Entity of an Educational Innovation: The Realities of Micropolitics

    Science.gov (United States)

    Raksit, Mandira

    2006-01-01

    This study was about a single case of educational innovation and excellence in educational technology in a secondary school in Ontario. The researcher explored the question of how the innovation resulted from an individual effort and attainment remained a "contained entity" after its decade-long existence. From the lenses of multiple realities,…

  6. Solitary cysticercosis affecting deltoid muscle: A rare entity

    OpenAIRE

    Geeta Purohit; Sarita Mohapatra; Sonam Sharma; Manorama Deb

    2015-01-01

    Cysticercosis is a common parasitic infection in developing countries involving the central nervous system (CNS), eye, skeletal muscle, and subcutaneous tissue. Solitary intramuscular cysticercosis without CNS involvement is a rare entity. Here, we present a case of solitary cysticercosis involving a rare muscular site without any neurologic or systemic manifestation.

  7. Ambras Syndrome with Gingival Hyperplasia: A Rare Entity.

    Science.gov (United States)

    Reddy Kundoor, Vinay Kumar; Maloth, Kotya Naik; Kesidi, Sunitha; Moni, Thakur

    2016-01-01

    Ambras syndrome is a rare and special form of congenital hypertrichosis, characterized by dysmorphic facial features and familial pattern of inheritance. It is rarely associated with gingival hyperplasia. We report such a rare entity in a 38-year-old female patient with a history of consanguinity and positive family history.

  8. Solitary cysticercosis affecting deltoid muscle: A rare entity

    Directory of Open Access Journals (Sweden)

    Geeta Purohit

    2015-01-01

    Full Text Available Cysticercosis is a common parasitic infection in developing countries involving the central nervous system (CNS, eye, skeletal muscle, and subcutaneous tissue. Solitary intramuscular cysticercosis without CNS involvement is a rare entity. Here, we present a case of solitary cysticercosis involving a rare muscular site without any neurologic or systemic manifestation.

  9. Testicular tumors

    Directory of Open Access Journals (Sweden)

    Giovanni Rosti

    2011-12-01

    Full Text Available Germ cell tumors of the testes represent a unique paradigm of diseases which can be cured even in extremely advanced phase. Unfortunately, this makes them unique among adult solid tumors. Seminoma and non seminoma are relatively rare with approximatively 25,000 patients in Europe per year, but numbers are increasing world wide. Different strategies are needed depending on stage and prognostic scores. Seminoma is extremely sensitive to radiation therapy and chemotherapy, while all germ cell tumors show a very good response to chemotherapy. Clinical stage I seminoma is currently treated with radiation, single course carboplatin or surveillance policy. Clinical stage I non seminoma can also be approached with different strategies such as retroperitoneal lymph node dissection, observation or one-two courses of standard chemotherapy. Stage II seminoma may be treated with either radiation or chemotherapy, while for all advanced stages chemotherapy is mandatory. Since the mid-eighties PEB (Cisplatin, Etoposide and Bleomycin is the regimen of choice and no other schedule has proved superior in terms of efficacy. Surgery on the residual disease is crucial to the whole strategy and should be performed or attempted in all cases. Consequently, the correct treatment strategy for these tumors does not depend only on the ability of a single physician, but on a skilled team specialized in this particular tumor. Second line therapies (VeIP, PEI, TIP can cure 25%–40% of patients, but improved strategies for resistant tumors are desperately needed. High-dose chemotherapy has shown very good results in some studies while being less impressive in others. In any case, it should remain an option for relapsing patients and could be used in some cases of upfront chemotherapy in patients with slow marker decline, but this should only be considered in referring centers.

  10. Performance Audit in Public Sector Entities - A New Challenge for Eastern European Countries

    Directory of Open Access Journals (Sweden)

    Adriana TIRON TUDOR

    2007-02-01

    Full Text Available Performance measurement provides an objective basis for evaluating how efficiently public resources are being used and how effectively public service outcomes are being achieved. It is a process used to support government selfanalysis and provide a basis for more informed and publicly defensible decision-making. In this context an important role is reserved to performance external audit performed by external audit institutions. The performance audit analyses the quality of financial administration from the point of view of the three elements of performance: economy, efficiency and effectiveness. We intend to realize a comparative study for some Eastern European countries regarding the performance audit, knowing the fact that since countries differ at the level of individual reforms, there is no single model of reform. Nonetheless, reform strategies have many points in common emphasizing the international character of public management reform. By cross-national comparisons we intend to analyze the impact of implementing the new performance audit in certain Eastern European Countries, and in Romania, focused on the external audit institutions.

  11. Semantic Entity Pairing for Improved Data Validation and Discovery

    Science.gov (United States)

    Shepherd, Adam; Chandler, Cyndy; Arko, Robert; Chen, Yanning; Krisnadhi, Adila; Hitzler, Pascal; Narock, Tom; Groman, Robert; Rauch, Shannon

    2014-05-01

    One of the central incentives for linked data implementations is the opportunity to leverage the rich logic inherent in structured data. The logic embedded in semantic models can strengthen capabilities for data discovery and data validation when pairing entities from distinct, contextually-related datasets. The creation of links between the two datasets broadens data discovery by using the semantic logic to help machines compare similar entities and properties that exist on different levels of granularity. This semantic capability enables appropriate entity pairing without making inaccurate assertions as to the nature of the relationship. Entity pairing also provides a context to accurately validate the correctness of an entity's property values - an exercise highly valued by data management practices who seek to ensure the quality and correctness of their data. The Biological and Chemical Oceanography Data Management Office (BCO-DMO) semantically models metadata surrounding oceanographic researchcruises, but other sources outside of BCO-DMO exist that also model metadata about these same cruises. For BCO-DMO, the process of successfully pairing its entities to these sources begins by selecting sources that are decidedly trustworthy and authoritative for the modeled concepts. In this case, the Rolling Deck to Repository (R2R) program has a well-respected reputation among the oceanographic research community, presents a data context that is uniquely different and valuable, and semantically models its cruise metadata. Where BCO-DMO exposes the processed, analyzed data products generated by researchers, R2R exposes the raw shipboard data that was collected on the same research cruises. Interlinking these cruise entities expands data discovery capabilities but also allows for validating the contextual correctness of both BCO-DMO's and R2R's cruise metadata. Assessing the potential for a link between two datasets for a similar entity consists of aligning like

  12. Fine-needle aspiration cytology of soft tissue lesions: diagnostic challenges.

    Science.gov (United States)

    Domanski, Henryk A

    2007-12-01

    Clinical and radiographic data provide important information in the evaluation of soft tissue lesions/neoplasms. Morphologic tissue and cytologic examination is considered to be a necessary part of the diagnostic work-up. The standard procedure for obtaining tumor tissue for morphologic evaluation has been incisional (open) or core needle biopsy. An increasing use of minimally invasive diagnostic procedures has resulted in better acceptance of fine-needle aspiration cytology (FNAC) in the diagnosis of soft tissue lesions. This article discusses challenges in FNAC of soft tissue lesions based on the experience at a multidisciplinary referral sarcoma center. Obtaining sufficient specimens from deeply seated small and necrotic/cystic lesions is technically a potential pitfall and misdiagnosis of cells from reactive zones surrounding the tumor as well as the correct evaluation of spindle cell lesions, rare soft tissue neoplasms, and "new entities" lacking reproducible cytological criteria are other important challenges in FNAC of soft tissues. The successful cytological evaluation of soft tissue lesions requires the application of strict, reproducible morphological criteria in the context of the clinical findings as well as ancillary techniques. The minimal criteria for diagnostic intervention in various clinical settings and the relative advantages and disadvantages of FNAC must be understood. FNAC of soft tissue lesions is facilitated when limited to specialized orthopedic-oncologic centers with a well-integrated multidisciplinary team and experience in the evaluation and therapy of soft tissue lesions. PMID:18008345

  13. Superior sulcus tumors (Pancoast tumors).

    Science.gov (United States)

    Marulli, Giuseppe; Battistella, Lucia; Mammana, Marco; Calabrese, Francesca; Rea, Federico

    2016-06-01

    Superior Sulcus Tumors, frequently termed as Pancoast tumors, are a wide range of tumors invading the apical chest wall. Due to its localization in the apex of the lung, with the potential invasion of the lower part of the brachial plexus, first ribs, vertebrae, subclavian vessels or stellate ganglion, the superior sulcus tumors cause characteristic symptoms, like arm or shoulder pain or Horner's syndrome. The management of superior sulcus tumors has dramatically evolved over the past 50 years. Originally deemed universally fatal, in 1956, Shaw and Paulson introduced a new treatment paradigm with combined radiotherapy and surgery ensuring 5-year survival of approximately 30%. During the 1990s, following the need to improve systemic as well as local control, a trimodality approach including induction concurrent chemoradiotherapy followed by surgical resection was introduced, reaching 5-year survival rates up to 44% and becoming the standard of care. Many efforts have been persecuted, also, to obtain higher complete resection rates using appropriate surgical approaches and involving multidisciplinary team including spine surgeon or vascular surgeon. Other potential treatment options are under consideration like prophylactic cranial irradiation or the addition of other chemotherapy agents or biologic agents to the trimodality approach.

  14. Inflammatory myofibroblastic tumor

    Directory of Open Access Journals (Sweden)

    Sangeeta Palaskar

    2011-01-01

    Full Text Available Inflammatory myofibroblastic tumor is an uncommon lesion of unknown cause. It encompasses a spectrum of myofibroblastic proliferation along with varying amount of inflammatory infiltrate. A number of terms have been applied to the lesion, namely, inflammatory pseudotumor, fibrous xanthoma, plasma cell granuloma, pseudosarcoma, lymphoid hamartoma, myxoid hamartoma, inflammatory myofibrohistiocytic proliferation, benign myofibroblatoma, and most recently, inflammatory myofibroblastic tumor. The diverse nomenclature is mostly descriptive and reflects the uncertainty regarding true biologic nature of these lesions. Recently, the concept of this lesion being reactive has been challenged based on the clinical demonstration of recurrences and metastasis and cytogenetic evidence of acquired clonal chromosomal abnormalities. We hereby report a case of inflammatory pseudotumor and review its inflammatory versus neoplastic behavior.

  15. Semanticizing Search Engine Queries: The University of Amsterdam at the ERD 2014 Challenge

    NARCIS (Netherlands)

    D. Graus; D. Odijk; M. Tsagkias; W. Weerkamp; M. de Rijke

    2014-01-01

    This paper describes the University of Amsterdam's participation in the short track of the Entity Recognition & Disambiguation Challenge 2014 (ERD 2014). We describe how we adapt the Semanticizer---an open-source entity linking framework developed primarily at the University of Amsterdam---to the ta

  16. 78 FR 3317 - Removal of Persons From the Entity List Based on Removal Request; Implementation of Entity List...

    Science.gov (United States)

    2013-01-16

    ... Emirates FZ-LLC, Office 124 1st Floor, Building 3, Dell Building, Sheikh Zayed Road, Dubai Internet City..., Dell Building, Sheikh Zayed Road, Dubai Internet City, Dubai, U.A.E.'' The addition reads as follows... . SUPPLEMENTARY INFORMATION: Background The Entity List (Supplement No. 4 to Part 744) notifies the public...

  17. 77 FR 24587 - Addition of Certain Persons to the Entity List; and Implementation of Entity List Annual Review...

    Science.gov (United States)

    2012-04-25

    ... information regarding the acquisition or attempted acquisition of electronic components and devices capable of being used in improvised explosive devices (IEDs) used against Coalition Forces in Iraq and Afghanistan... Entity List person (76 FR 37632, 6/28/2011). Therefore, pursuant to Section 744.11(b)(5) of the EAR,...

  18. Active Roles of Tumor Stroma in Breast Cancer Metastasis

    Directory of Open Access Journals (Sweden)

    Zahraa I. Khamis

    2012-01-01

    Full Text Available Metastasis is the major cause of death for breast cancer patients. Tumors are heterogenous cellular entities composed of cancer cells and cells of the microenvironment in which they reside. A reciprocal dynamic interaction occurs between the tumor cells and their surrounding stroma under physiological and pathological conditions. This tumor-host communication interface mediates the escape of tumor cells at the primary site, survival of circulating cancer cells in the vasculature, and growth of metastatic cancer at secondary site. Each step of the metastatic process is accompanied by recruitment of stromal cells from the microenvironment and production of unique array of growth factors and chemokines. Stromal microenvironment may play active roles in breast cancer metastasis. Elucidating the types of cells recruited and signal pathways involved in the crosstalk between tumor cells and stromal cells will help identify novel strategies for cotargeting cancer cells and tumor stromal cells to suppress metastasis and improve patient outcome.

  19. Primary renal primitive neuroectodermal tumor: A rare presentation

    Directory of Open Access Journals (Sweden)

    V Goel

    2015-01-01

    Full Text Available Primitive Neuroectodermal Tumor of the kidney is a rare entity. Very few cases of primary renal PNET have been reported to date. Most literature about rPNET is isolated case reports. We report a case of rPNET in a 39-year-old male with a pre-operative diagnosis of renal cell carcinoma with renal vein thrombosis. The patient underwent radical nephrectomy with thrombolectomy, and histopathological examination revealed a highly aggressive tumor composed of monotonous sheets of round cells. Tumor cells were positive for CD 99 and FLI-1, hence confirming the diagnosis of Primitive Neuroectodermal Tumor. Post-surgery, patient was given VAC/IE-based adjuvant chemotherapy. In view of highly aggressive nature of this tumor, prompt diagnosis and imparting effective chemotherapy regimen to the patient is required, and it is important to differentiate PNET from other small round-cell tumors because of different therapeutic approach.

  20. Incidental intraoperative discovery of a pancreatic neuroendocrine tumor associated with chronic pancreatitis

    OpenAIRE

    Surlin Valeriu; Ramboiu Sandu; Ghilusi Mirela; Plesea Iancu

    2012-01-01

    Abstract Pancreatic neuroendocrine tumors are a rare entity with an incidence between 2 per million to 5 per 100 000. Association with pancreatitis (acute or chronic) is rare and is considered to be determined by the tumoral obstruction of pancreatic ducts, but sometimes occurs without any apparent relationship between them. Non-functional neuroendocrine pancreatic tumors are usually diagnosed when either very large or metastatic. Small ones are occasionally diagnosed when imagery is performe...

  1. Chitinase-3-like-1/YKL-40 as marker of circulating tumor cells

    OpenAIRE

    Hamilton, Gerhard; Rath, Barbara; Burghuber, Otto

    2015-01-01

    Ex vivo expansion of circulating tumor cells (CTCs) of small cell lung cancer (SCLC) patients enabled systematic screening of secreted cytokines. Permanent CTC cultures of different patients shared secretion of chitinase-3-like-1 (CHI3L1)/YKL-40, known to be upregulated in a range of tumor entities and to be associated with increased metastasis and decreased survival. This protein lacks enzymatic activity and its mechanism of promoting tumor dissemination has not been resolved. Results from S...

  2. Clear cell variant of calcifying epithelial odontogenic tumor of maxilla: Report of a rare case.

    Science.gov (United States)

    Badrashetty, Dinesh; Rangaswamy, Shruthi; Belgode, Niranjan

    2013-09-01

    The calcifying epithelial odontogenic tumor (CEOT) is a rare benign tumor of the jaws. Pindborg's tumor having clear cells is extremely rare. Twelve central lesions have been reported of which only three cases have occurred in maxilla. Clear cell variant is a distinct entity, has more aggressive biological behavior and higher chances of recurrence. Hence it is important that presence of clear cells be included in histopathological diagnosis. Here we present a rare case of clear cell CEOT having aggressive behavior.

  3. Apocrine carcinoma of the male breast: a case report of an exceptional tumor

    OpenAIRE

    Sekal, Mohammed; Znati, Kaoutar; Harmouch, Taoufiq; Riffi, Afaf Amarti

    2014-01-01

    Apocrine carcinoma of the male breast is an exceptional malignant tumor. It does not have a particular clinical or radiological appearance, but it's microscopically characterized by the presence of granular cells and foamy cells representing over 90% of tumor cells. These cells express most of the time the GCDFP-15 and the androgen receptors. This tumor is a distinct molecular entity. In this observation, we report the case of a 70 year old man presenting apocrine carcinoma of the left breast...

  4. Endometrioid Paraovarian Borderline Cystic Tumor in an Infant with Proteus Syndrome

    OpenAIRE

    Liliana Vasquez; Mariela Tello; Ivan Maza; Monica Oscanoa; Milagros Dueñas; Haydee Castro; Alan Latorre

    2015-01-01

    Ovarian and paraovarian neoplasms are uncommon in children, mainly originating from germ cell tumors and, least frequently, epithelial tumors. There is an association between genital tract tumors and Proteus syndrome, a rare, sporadic, and progressive entity, characterized by a postnatal overgrowth in several tissues caused by a mosaic mutation in the AKT1 gene. We describe a 20-month-old asymptomatic infant with Proteus syndrome who developed an endometrioid paraovarian borderline cystic tum...

  5. Small round blue cell tumor of seminal vesicle in a young patient

    Directory of Open Access Journals (Sweden)

    Adriano A. De Paula

    2006-10-01

    Full Text Available Seminal vesicle tumor is a rare disease with unclear origin. Generally, it is presented as a pelvic mass that can be detected by sonography and digital rectal exam. The authors report a 25-year-old patient with a pelvic mass which the magnetic resonance and surgical specimen reveal a seminal vesicle tumor. Immunohistochemical findings favored a primitive neuroectodermal tumor of the seminal vesicle. Herein, the treatment, histological and histochemical findings of this entity are discussed.

  6. Metonimy resolution for named entities: an hybrid approach Résolution de métonymie des entités nommées : proposition d'une méthode hybride

    OpenAIRE

    Caroline Brun; Maud Ehrmann; Guillaume Jacquet

    2010-01-01

    Named Entity metonymy resolution is a challenging natural langage processing task, which has been recently subject to a growing interest. In this paper, we describe the method we have developed in order to solve Named entity metonymy in the framework of the SemEval 2007 competition. In order to perform Named Entity metonymy resolution on location names and company names, as required for this task, we developed a hybrid system based on the use of a robust parser that extracts deep syntactic re...

  7. Stump Appendicitis: An Uncompleted Surgery, a Rare but Important Entity with Potential Problems

    Directory of Open Access Journals (Sweden)

    J. A. A. Awe

    2013-01-01

    Full Text Available Appendicectomy for appendicitis is one of the commonest surgical procedures performed worldwide. The residual appendiceal stump left after an initial appendectomy risks the development of stump appendicitis. Stump appendicitis is a real recognized entity but not often considered when evaluating patients with right lower quadrant abdominal pain, especially those with past history of appendectomy. It remains a clinical challenge with the result that its diagnosis and effective treatment are often delayed with possible attendant morbidity or mortality. Stump appendicitis results from obstruction of the lumen of the remaining appendix stump, usually by a faecolith. This increases intraluminal pressure, impairing venous drainage and allowing subsequent bacterial infection. We present the case of a twenty-five (25-year-old female who underwent laparoscopic appendicectomy and presented four and half (4(1/2 months later with fever, right lower quadrant abdominal pain, and tenderness associated with repeated vomiting. Exploratory laparotomy was carried out after clinical and imaging studies which revealed big inflammatory mass with abscess at the right iliac fossa and recurrent appendicitis of the appendiceal stump. Surgical treatment is easy but recognition of this important entity but potentially dangerous condition should always be borne in mind in order to avoid delay in its diagnosis and treatment.

  8. INTER–ORGANIZATIONAL COLLABORATIVE CAPACITY OF PUBLIC SECTOR INSTITUTIONS’CONTROL ENTITIES IN EMERGENCY SITUATIONS

    Directory of Open Access Journals (Sweden)

    Nikola T. STOYANOV

    2015-10-01

    Full Text Available Environmental challenges and natural disasters demand new tools to support the performance of public institutions in emergency situations. This paper contributes to one of the fundamental objectives – inter–organizational collaboration, namely to the objective to share experience from the implementation of methods and tools and latest research results in support of management in the new security environment. In addition, it focuses on the cognitive and human aspects of collaboration. The goal of the paper is to investigate the impact of different factors and tools for understanding, explaining, and measuring collaborative capacity of public sector institutions’ control organism in emergency situations. The paper will present intermediate results from the research on “Inter–organizational collaborative capacity of public sector institutions’ control entities in emergency situations”. Based on a theoretical model, a draft instrument was developed (i.e., a questionnaire for data collection that can be used to 1 investigate the impact of different factors, 2 localize inefficiencies in public sector institutions’ control organs, and 3 determine measures to achieve better organizational effectiveness of public sector institutions’ control entities in emergency situations.

  9. Iliopsoas abscess: a re-emerging clinical entity not to be forgotten.

    LENUS (Irish Health Repository)

    Al-Hilli, Z

    2009-02-01

    Iliopsoas abscesses are relatively rare clinical entities. They present with subtle and non-specific symptoms and as a result the diagnosis is often delayed, leading to significant morbidity and mortality. With an increasing number of immunocompromised patients in the population the prevalence of this condition is set to rise. Therefore, early diagnosis and appropriate management remain a challenge for clinicians. We present three patients with iliopsoas abscesses, two of which were primary and one of which was secondary to Crohn\\'s disease. The average age of patients was 59 years and both patients with primary psoas abscesses were male. All presented with non-specific symptoms. Psoas sign was present in only one patient. CT confirmed the diagnosis in all cases. Treatment consisted of appropriate antibiotic cover and associated percutaneous drainage. The psoas abscess that was secondary to underlying Crohn\\'s disease was subsequently treated with surgical excision of the affected segment of bowel and lavage of the abscess cavity. A high index of suspicion is required to ensure the accurate and early diagnosis of this rare clinical entity. Abdominal CT scanning remains the gold standard for diagnosis. Management is with appropriate antibiotics and adequate drainage. This can be achieved by either percutaneous or surgical drainage. Such treatment can reduce the overall morbidity and mortality of this condition.

  10. Chemical entity recognition in patents by combining dictionary-based and statistical approaches.

    Science.gov (United States)

    Akhondi, Saber A; Pons, Ewoud; Afzal, Zubair; van Haagen, Herman; Becker, Benedikt F H; Hettne, Kristina M; van Mulligen, Erik M; Kors, Jan A

    2016-01-01

    We describe the development of a chemical entity recognition system and its application in the CHEMDNER-patent track of BioCreative 2015. This community challenge includes a Chemical Entity Mention in Patents (CEMP) recognition task and a Chemical Passage Detection (CPD) classification task. We addressed both tasks by an ensemble system that combines a dictionary-based approach with a statistical one. For this purpose the performance of several lexical resources was assessed using Peregrine, our open-source indexing engine. We combined our dictionary-based results on the patent corpus with the results of tmChem, a chemical recognizer using a conditional random field classifier. To improve the performance of tmChem, we utilized three additional features, viz. part-of-speech tags, lemmas and word-vector clusters. When evaluated on the training data, our final system obtained an F-score of 85.21% for the CEMP task, and an accuracy of 91.53% for the CPD task. On the test set, the best system ranked sixth among 21 teams for CEMP with an F-score of 86.82%, and second among nine teams for CPD with an accuracy of 94.23%. The differences in performance between the best ensemble system and the statistical system separately were small.Database URL: http://biosemantics.org/chemdner-patents.

  11. Chemical entity recognition in patents by combining dictionary-based and statistical approaches.

    Science.gov (United States)

    Akhondi, Saber A; Pons, Ewoud; Afzal, Zubair; van Haagen, Herman; Becker, Benedikt F H; Hettne, Kristina M; van Mulligen, Erik M; Kors, Jan A

    2016-01-01

    We describe the development of a chemical entity recognition system and its application in the CHEMDNER-patent track of BioCreative 2015. This community challenge includes a Chemical Entity Mention in Patents (CEMP) recognition task and a Chemical Passage Detection (CPD) classification task. We addressed both tasks by an ensemble system that combines a dictionary-based approach with a statistical one. For this purpose the performance of several lexical resources was assessed using Peregrine, our open-source indexing engine. We combined our dictionary-based results on the patent corpus with the results of tmChem, a chemical recognizer using a conditional random field classifier. To improve the performance of tmChem, we utilized three additional features, viz. part-of-speech tags, lemmas and word-vector clusters. When evaluated on the training data, our final system obtained an F-score of 85.21% for the CEMP task, and an accuracy of 91.53% for the CPD task. On the test set, the best system ranked sixth among 21 teams for CEMP with an F-score of 86.82%, and second among nine teams for CPD with an accuracy of 94.23%. The differences in performance between the best ensemble system and the statistical system separately were small.Database URL: http://biosemantics.org/chemdner-patents. PMID:27141091

  12. Bar code hotel: diverse interactions of semi-autonomous entities under the partial control of multiple operators

    Science.gov (United States)

    Hoberman, Perry

    1995-03-01

    In this paper I describe an interactive installation that was produced in 1994 as one of eight Art and Virtual Environments projects sponsored by the Banff Center for the Arts. The installation, Bar Code Hotel, makes use of a number of strategies to create a casual, social, multi-person interface. Among the goals was to investigate methods that would minimize any significant learning curve, allowing visitors to immediately interact with a virtual world in a meaningful way. By populating this virtual world with semi-independent entities that could be directed by participants even as these entities were interacting with each other, a rich and heterogeneous experience was produced in which a variety of relationships between human participants and virtual objects could be examined. The paper will describe some of the challenges of simultaneously processing multiple input sources affecting a virtual environment in which each object already has its own ongoing behavior.

  13. CONTROVERSIAL ASPECTS REGARDING APPOINTING AND REVOKING THE LEGAL ENTITY ADMINISTRATOR

    Directory of Open Access Journals (Sweden)

    CARMEN TODICA

    2012-05-01

    Full Text Available Having as main objective the analysis the provisions of Company Law and the New Civil Code regarding the management of a trading company by a legal person, the study offers several solutions to a number of controversial issues with strict reference to two aspects: appointing and revoking the legal entity administrator. Can the administrator be any entity with a legal personality or just a trade company? Is the administrator subject to legal requirements of good repute, characteristic to a representative natural person? Can the legal person fulfill the president position in a collective administrative body? Can he be revoked ad nutum? Regarding the administrator legal person representative, may the company revoke the administrator, on its own? There are several questions outlining the juridical status of the administrator legal person, and to which the paper tries to find answers, introducing some jurisprudence solutions, comparative law issues and controversial doctrinal views.

  14. Noncholesteatomatous Cyst of the Tympanic Membrane: A Nonpublished Entity?

    Directory of Open Access Journals (Sweden)

    Rafael Ramírez-Camacho

    2015-01-01

    Full Text Available Introduction. The presence of a serous cyst in the tympanic membrane implies the description of a new or unpublished entity based on our knowledge whose origin may be very unlikely explained on actual embryologic and anatomic background. Clinical Case. We present a case of a 45-year-old woman with progressing right hearing loss. Physical examination revealed a whitish, round-shaped malformation in the posterior-inferior quadrant of the right tympanic membrane. The cyst was removed with a transcanal tympanoplasty. Discussion. A thorough PubMed search that involved the terms tympanic membrane gland, epithelial inclusion cysts, mucous-secreting cyst, and tympanic cyst has shown no positive results. The first description of an unknown entity, such as a tympanic membrane serous cyst, may be the key for clinicians to start paying attention to patients who suffer from similar pathologies and may pass unnoticed because of their rarity or peculiarity.

  15. Orthokeratinized Odontogenic Cyst (OOC) of Condylar Head: A Rare Entity.

    Science.gov (United States)

    Managutti, Anil; Managutti, Sunita; Patel, Harsh; Menat, Shailesh

    2016-07-01

    Orthokeratinized odontogenic cyst (OOC) is a rare developmental jaw cyst, considered as distinct entity from odontogenic keratocysts as it exhibits a less aggressive behaviour and a very low rate of recurrence. Most commonly occurs in mandibular molar and ramus region, rarely seen in maxilla and mandibular premolar area. But till now never reported in condyle, this article describes a case of OOC involving the mandibular condylar head in a 41-year-old male. The initial clinical diagnosis was given as TMD based on the clinical features, but radiographic evaluation revealed osteolytic lesion in right side condylar head. Condylotomy was performed and the specimen was sent for histopathological examination. A definite diagnosis of OOC was made by histopathological examination of the biopsy specimen. We report a rare entity in this article with its management.

  16. Joint Event Detection and Entity Resolution: a Virtuous Cycle

    OpenAIRE

    Galle, Matthias; Renders, Jean-Michel; Jacquet, Guillaume

    2016-01-01

    Clustering web documents has numerous applications, such as aggregating news articles into meaningful events, detecting trends and hot topics on the Web, preserving diversity in search results, etc. At the same time, the importance of named entities and, in particular, the ability to recognize them and to solve the associated co-reference resolution problem are widely recognized as key enabling factors when mining, aggregating and comparing content on the Web. Instead of considering these two...

  17. A STRATEGIC ANALYSIS OF THE NOT-FOR-PROFIT ENTITY

    OpenAIRE

    Tang, Brenda

    2009-01-01

    MoreSports offers valuable and accessible sports programming to children in east side Vancouver; its focus is on inclusion in a fun, non-competitive environment. Functioning as a not-for-profit (although not a legal entity), this organization brings together stakeholders within each community, including institutions such as the Vancouver School Board and Vancouver Park Board, to pool their resources towards program provision. Through its hub-based collaborative partnerships, MoreSports fills ...

  18. The Budgets’ Role in the Audit of Economic Entities

    OpenAIRE

    Tanase Gabriela Lidia

    2013-01-01

    The audit of economic entities is a necessity, giving assurances regarding the integrity and efficiency of management, efficiency and effectiveness of control measures, and fairness of financial statements. Budgets are useful tools in business management and decision making, which allow management to achieve superior results through effective resource management and proper planning of activities. The purpose of this research is to highlight the budgets’ importance and role in the audit of eco...

  19. Paradental Cyst (Inflammatory Collateral Cyst: A True Clinicopathologic Entity

    Directory of Open Access Journals (Sweden)

    Raveendranath Rajendran

    2015-07-01

    Full Text Available Paradental cy st is an inflammatory odontogenic cyst arising in association with partially erupted third molars affected with pericoronitis. The common location is on the buccal aspect of the molar teeth. Radiographically, the characteristic presen­ tation is a well defined radiolucency superimposed on the roots. Histologically, cysts were lined with nonkeratinized epithelium. The various concepts underlining the origin/pathogenesis of this rare entity is discussed and critically apprised.

  20. Hybrid Approach to English-Hindi Name Entity Transliteration

    OpenAIRE

    Mathur, Shruti; Saxena, Varun Prakash

    2014-01-01

    Machine translation (MT) research in Indian languages is still in its infancy. Not much work has been done in proper transliteration of name entities in this domain. In this paper we address this issue. We have used English-Hindi language pair for our experiments and have used a hybrid approach. At first we have processed English words using a rule based approach which extracts individual phonemes from the words and then we have applied statistical approach which converts the English into its...

  1. Chemical named entities recognition: a review on approaches and applications

    OpenAIRE

    Eltyeb, Safaa; Salim, Naomie

    2014-01-01

    The rapid increase in the flow rate of published digital information in all disciplines has resulted in a pressing need for techniques that can simplify the use of this information. The chemistry literature is very rich with information about chemical entities. Extracting molecules and their related properties and activities from the scientific literature to “text mine” these extracted data and determine contextual relationships helps research scientists, particularly those in drug developmen...

  2. The ontology of medically related social entities: recent developments

    OpenAIRE

    Hicks, Amanda; Hanna, Josh; Welch, Daniel; Brochhausen, Mathias; Hogan, William R.

    2016-01-01

    Background The Ontology of Medically Related Social Entities (OMRSE) was initially developed in 2011 to provide a framework for modeling demographic data in Resource Description Framework/Web Ontology Language. It is built upon the Basic Formal Ontology and conforms to Open Biomedical Ontologies Foundry’s best practices. Description We report recent development of OMRSE which includes representations of organizations, roles, facilities, demographic data, enrollment in insurance plans, and dat...

  3. Xanthogranulomatous Endometritis: An Unusual Pathological Entity Mimicking Endometrial Carcinoma

    Science.gov (United States)

    Makkar, M; Gill, MK; Singh, DP

    2013-01-01

    Xanthogranulomatous endometritis is an unusual pathological entity mimicking endometrial carcinoma. This shows sheets of foamy histiocytes alongwith other inflammatory cells. We, hereby, report a case of 45 year multigravida female with irregular menstrual history, clinically diagnosed as carcinoma and histopathologically turned out as xanthogranulomatous endometritis. So, this condition should always be dealt with caution, and pathologists and clinicians should be aware of it. PMID:24349850

  4. Strategic Management Accounting Within Business Entities Integrated Management System

    OpenAIRE

    Valentyna Khodzytska; Larysa Ivchenko

    2014-01-01

    Proposed by scientists in the late 80s, new approaches to be up-to-date with the competitive business environment, led to identification of the so-called strategic management accounting. The article covers the main aspects of the impact of strategic management accounting on making efficient management decisions in comprehensive system of business entities management. Based on the study of scientific approaches to the concept of strategic management accounting in modern conditions the authors ...

  5. Arabic Named Entity Recognition Using Artificial Neural Network

    Directory of Open Access Journals (Sweden)

    Naji F. Mohammed

    2012-01-01

    Full Text Available Problem statement: Named Entity Recognition (NER is a task to identify proper names as well as temporal and numeric expressions, in an open-domain text. The NER task can help to improve the performance of various Natural Language Processing (NLP applications such as Information Extraction (IE, Information Retrieval (IR and Question Answering (QA tasks. This study discusses on the Named Entity Recognition of Arabic (NERA. The motivation is due to the lack of resources for Arabic named entities and to enhance the accuracy that has been reached in previous NERA systems. Approach: This system is designed based on neural network approach. The main task of neural network approach is to automatically learn to recognize component patterns and make intelligent decisions based on available data and it can also be applied to classify new information within large databases. The use of machine learning approach to classify NER from Arabic text based on neural network technique is proposed. Neural network approach has performed successfully in many areas of artificial intelligence. The system involves three stages: the first stage is pre-processing that cleans the collected data, the second involves converting Arabic letters to Roman alphabets and the final stage applies neural network to classify the collected data. Results: The accuracy of the system is 92 %. The system is compared with decision tree using the same data. The results showed that the neural network approach achieved better than decision tree. Conclusion: These results prove that our technique is capable to recognize named entities of Arabic texts.

  6. Representing electrons a biographical approach to theoretical entities

    CERN Document Server

    Arabatzis, Theodore

    2006-01-01

    Both a history and a metahistory, Representing Electrons focuses on the development of various theoretical representations of electrons from the late 1890s to 1925 and the methodological problems associated with writing about unobservable scientific entities. Using the electron-or rather its representation-as a historical actor, Theodore Arabatzis illustrates the emergence and gradual consolidation of its representation in physics, its career throughout old quantum theory, and its appropriation and reinterpretation by chemists. As Arabatzis develops this novel biographical

  7. Business Environment and Corporate Governance in Public Entities

    OpenAIRE

    Eugen Nicolaescu

    2012-01-01

    For several years, private business has adopted corporative governance on the grounds of national and international codes to enhance investor confidence in companies and economic entities, especially those that are listed on the stock exchanges. The business environment for the public sector has not benefited from corporate governance due to certain bureaucratic, but logical reasons, such as the fact that the representatives of the State/Government/local authority apply the shareholder’s deci...

  8. Modeling discrete and continuous entities with fractions and decimals.

    Science.gov (United States)

    Rapp, Monica; Bassok, Miriam; DeWolf, Melissa; Holyoak, Keith J

    2015-03-01

    When people use mathematics to model real-life situations, their use of mathematical expressions is often mediated by semantic alignment (Bassok, Chase, & Martin, 1998): The entities in a problem situation evoke semantic relations (e.g., tulips and vases evoke the functionally asymmetric "contain" relation), which people align with analogous mathematical relations (e.g., the noncommutative division operation, tulips/vases). Here we investigate the possibility that semantic alignment is also involved in the comprehension and use of rational numbers (fractions and decimals). A textbook analysis and results from two experiments revealed that both mathematic educators and college students tend to align the discreteness versus continuity of the entities in word problems (e.g., marbles vs. distance) with distinct symbolic representations of rational numbers--fractions versus decimals, respectively. In addition, fractions and decimals tend to be used with nonmetric units and metric units, respectively. We discuss the importance of the ontological distinction between continuous and discrete entities to mathematical cognition, the role of symbolic notations, and possible implications of our findings for the teaching of rational numbers. PMID:25401267

  9. Unsupervised entity and relation extraction from clinical records in Italian.

    Science.gov (United States)

    Alicante, Anita; Corazza, Anna; Isgrò, Francesco; Silvestri, Stefano

    2016-05-01

    This paper proposes and discusses the use of text mining techniques for the extraction of information from clinical records written in Italian. However, as it is very difficult and expensive to obtain annotated material for languages different from English, we only consider unsupervised approaches, where no annotated training set is necessary. We therefore propose a complete system that is structured in two steps. In the first one domain entities are extracted from the clinical records by means of a metathesaurus and standard natural language processing tools. The second step attempts to discover relations between the entity pairs extracted from the whole set of clinical records. For this last step we investigate the performance of unsupervised methods such as clustering in the space of entity pairs, represented by an ad hoc feature vector. The resulting clusters are then automatically labelled by using the most significant features. The system has been tested on a fairly large data set of clinical records in Italian, investigating the variation in the performance adopting different similarity measures in the feature space. The results of our experiments show that the unsupervised approach proposed is promising and well suited for a semi-automatic labelling of the extracted relations. PMID:26851833

  10. SIGNOR: a database of causal relationships between biological entities.

    Science.gov (United States)

    Perfetto, Livia; Briganti, Leonardo; Calderone, Alberto; Perpetuini, Andrea Cerquone; Iannuccelli, Marta; Langone, Francesca; Licata, Luana; Marinkovic, Milica; Mattioni, Anna; Pavlidou, Theodora; Peluso, Daniele; Petrilli, Lucia Lisa; Pirrò, Stefano; Posca, Daniela; Santonico, Elena; Silvestri, Alessandra; Spada, Filomena; Castagnoli, Luisa; Cesareni, Gianni

    2016-01-01

    Assembly of large biochemical networks can be achieved by confronting new cell-specific experimental data with an interaction subspace constrained by prior literature evidence. The SIGnaling Network Open Resource, SIGNOR (available on line at http://signor.uniroma2.it), was developed to support such a strategy by providing a scaffold of prior experimental evidence of causal relationships between biological entities. The core of SIGNOR is a collection of approximately 12,000 manually-annotated causal relationships between over 2800 human proteins participating in signal transduction. Other entities annotated in SIGNOR are complexes, chemicals, phenotypes and stimuli. The information captured in SIGNOR can be represented as a signed directed graph illustrating the activation/inactivation relationships between signalling entities. Each entry is associated to the post-translational modifications that cause the activation/inactivation of the target proteins. More than 4900 modified residues causing a change in protein concentration or activity have been curated and linked to the modifying enzymes (about 351 human kinases and 94 phosphatases). Additional modifications such as ubiquitinations, sumoylations, acetylations and their effect on the modified target proteins are also annotated. This wealth of structured information can support experimental approaches based on multi-parametric analysis of cell systems after physiological or pathological perturbations and to assemble large logic models. PMID:26467481

  11. Brain tumor - primary - adults

    Science.gov (United States)

    ... Vestibular schwannoma (acoustic neuroma) - adults; Meningioma - adults; Cancer - brain tumor (adults) ... Primary brain tumors include any tumor that starts in the brain. Primary brain tumors can start from brain cells, ...

  12. Brain tumor - children

    Science.gov (United States)

    ... children; Neuroglioma - children; Oligodendroglioma - children; Meningioma - children; Cancer - brain tumor (children) ... The cause of primary brain tumors is unknown. Primary brain tumors may ... (spread to nearby areas) Cancerous (malignant) Brain tumors ...

  13. Pediatric brain tumors

    Energy Technology Data Exchange (ETDEWEB)

    Poussaint, Tina Y. [Department of Radiology, Boston, MA (United States); Panigrahy, Ashok [Children' s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Department of Radiology, Pittsburgh, PA (United States); Huisman, Thierry A.G.M. [Charlotte R. Bloomberg Children' s Center, Johns Hopkins Hospital, Division of Pediatric Radiology and Pediatric Neuroradiology, Baltimore, MD (United States)

    2015-09-15

    Among all causes of death in children from solid tumors, pediatric brain tumors are the most common. This article includes an overview of a subset of infratentorial and supratentorial tumors with a focus on tumor imaging features and molecular advances and treatments of these tumors. Key to understanding the imaging features of brain tumors is a firm grasp of other disease processes that can mimic tumor on imaging. We also review imaging features of a common subset of tumor mimics. (orig.)

  14. 76 FR 47593 - Guidance for Small Business Entities on Current Good Manufacturing Practice for Positron Emission...

    Science.gov (United States)

    2011-08-05

    ... a guidance for small business entities entitled ``PET Drugs--Current Good Manufacturing Practice... entitled ``PET Drugs--Current Good Manufacturing Practice (CGMP); Small Entity Compliance Guide.'' This... Manufacturing Practice for Positron Emission Tomography Drugs; Availability AGENCY: Food and Drug...

  15. 76 FR 66074 - Small Entity Compliance Guide: Required Warnings for Cigarette Packages and Advertisements...

    Science.gov (United States)

    2011-10-25

    ... HUMAN SERVICES Food and Drug Administration Small Entity Compliance Guide: Required Warnings for... industry entitled ``Required Warnings for Cigarette Packages and Advertisements--Small Entity Compliance... the Center for Tobacco Products, Food and Drug Administration, 9200 Corporate Blvd., Rockville,...

  16. On Agricultural Scientific Research Institutions Supporting and Serving Technological Innovation Entities

    Institute of Scientific and Technical Information of China (English)

    Xiaoqiang; CHU; Bingqiang; XU; Hanchun; QIN; Guoyan; SHAN; Peiqun; LIN; Guixiu; HUANG

    2015-01-01

    This paper firstly analyzed current situation of agricultural technological innovation system in China and obstacles restricting agricultural enterprises to become technological innovation entities. It discussed exploration and practice of Chinese Academy of Tropical Agricultural Sciences in supporting and serving technological innovation entities. Finally,it came up with ideas and approaches for supporting and serving technological innovation entities in the new trend,to provide a new idea and practice for agricultural scientific research institute supporting and serving technological innovation entities.

  17. Semantic Label and Structure Model based Approach for Entity Recognition in Database Context

    OpenAIRE

    Kooli, Nihel; Belaïd, Abdel

    2015-01-01

    International audience —This paper proposes an entity recognition approach in scanned documents referring to their description in database records. First, using the database record values, the corresponding document fields are labeled. Second, entities are identified by their labels and ranked using a TF/IDF based score. For each entity, local labels are grouped into a graph. This graph is matched with a graph model (structure model) which represents geometric structures of local entity la...

  18. Teratoid Wilms′ tumor - A rare renal tumor

    Directory of Open Access Journals (Sweden)

    Biswanath Mukhopadhyay

    2011-01-01

    Full Text Available Teratoid Wilms′ tumor is an extremely rare renal tumor. We report a case of unilateral teratoid Wilms′ tumor in a 4-year-old girl. The patient was admitted with a right-sided abdominal mass. The mass was arising from the right kidney. Radical nephrectomy was done and the patient had an uneventful recovery. Histopathology report showed teratoid Wilms′ tumor.

  19. [Tumor surgery].

    Science.gov (United States)

    Hausamen, J E

    2000-05-01

    Surgery is still the primary therapeutic approach in treatment of tumors in the head and neck area, dating back to the early nineteenth century. More than 150 years ago, hemimaxillectomies and mandibular resections as well as hemiglossectomies were already performed by leading surgeons. The block principle we are now following dates back to Crile, who also established the principle of cervical lymph node dissection. Ablative oncologic surgery has always been closely linked with plastic and reconstructive surgery, rendering radical surgical interventions possible without disfiguring patients. The development of facial reconstructive surgery proceeded in stages, in the first instance as secondary reconstruction using tube pedicled flaps. The change to the concept of primary reconstruction occurred via arterialized skin flaps and myocutaneous flaps to the widely accepted and performed free tissue transfer. Free bone grafting, inaugurated earlier and still representing the majority of bone grafting, has been supplemented for certain reconstructive purposes by free vascularized bone transfer from various donor sites. Although the five-year-survival rate of carcinoma of the oral cavity has remained unchanged in the past 30 years, distinctive improvements in tumor surgery can be recorded. This is primarily based on improved diagnostics such as modern imaging techniques and the refinement of surgical techniques. The DOSAK has worked out distinctive guidelines for effective ablative oncologic surgery. Surgical approaches offering wide exposure and carrying low morbidity play a decisive role in radical resections. For this reason, midfacial degloving offers an essential improvement for the resection of midface tumors, especially from an aesthetic point of view. Tumors situated deep behind the viscerocranium at the skull base can be clearly exposed either through a lateral approach following a temporary osteotomy of the mandibular ramus or a transmandibular, transmaxillar, or

  20. Collaborative human-machine analysis to disambiguate entities in unstructured text and structured datasets

    Science.gov (United States)

    Davenport, Jack H.

    2016-05-01

    Intelligence analysts demand rapid information fusion capabilities to develop and maintain accurate situational awareness and understanding of dynamic enemy threats in asymmetric military operations. The ability to extract relationships between people, groups, and locations from a variety of text datasets is critical to proactive decision making. The derived network of entities must be automatically created and presented to analysts to assist in decision making. DECISIVE ANALYTICS Corporation (DAC) provides capabilities to automatically extract entities, relationships between entities, semantic concepts about entities, and network models of entities from text and multi-source datasets. DAC's Natural Language Processing (NLP) Entity Analytics model entities as complex systems of attributes and interrelationships which are extracted from unstructured text via NLP algorithms. The extracted entities are automatically disambiguated via machine learning algorithms, and resolution recommendations are presented to the analyst for validation; the analyst's expertise is leveraged in this hybrid human/computer collaborative model. Military capability is enhanced by these NLP Entity Analytics because analysts can now create/update an entity profile with intelligence automatically extracted from unstructured text, thereby fusing entity knowledge from structured and unstructured data sources. Operational and sustainment costs are reduced since analysts do not have to manually tag and resolve entities.

  1. 78 FR 30397 - Identification of Entity Pursuant to the Iranian Transactions and Sanctions Regulations and...

    Science.gov (United States)

    2013-05-22

    ... list of Specially Designated Nationals and Blocked Persons (``SDN List'') to identify this entity... Availability The SDN List and additional information concerning OFAC are available from OFAC's Web site ( www... Order and the ITSR, and updated the SDN List to identify this entity. The listing for this entity is...

  2. 42 CFR 405.1885 - Reopening an intermediary determination or reviewing entity decision.

    Science.gov (United States)

    2010-10-01

    ... reviewing entity decision. 405.1885 Section 405.1885 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... reviewing entity decision. (a) General. (1) A Secretary determination, an intermediary determination, or a decision by a reviewing entity (as described in § 405.1801(a) of this subpart) may be reopened,...

  3. 5 CFR 581.501 - Rules, regulations, and directives by governmental entities.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Rules, regulations, and directives by... Governmental Entities § 581.501 Rules, regulations, and directives by governmental entities. Appropriate officials of all governmental entities shall, to the extent necessary, issue implementing rules,...

  4. THE PLACE OF THE FORCED LIQUIDATION OF LEGAL ENTITIES IN THE SYSTEM OF CIVIL LIABILITY

    Directory of Open Access Journals (Sweden)

    Dmitriy Scheglov

    2015-07-01

    Full Text Available The definition of forced liquidation of the legal entity, the study of existing scientific approaches to the definition of the concept, an analysis of the legal entity attributes classification of legal entities, depending on the grounds for compulsory liquidation.

  5. 40 CFR 33.207 - Can an entity reapply to EPA for MBE or WBE certification?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Can an entity reapply to EPA for MBE or... ENVIRONMENTAL PROTECTION AGENCY PROGRAMS Certification § 33.207 Can an entity reapply to EPA for MBE or WBE certification? An entity which has been denied MBE or WBE certification may reapply for certification at...

  6. Malignant renal tumors in children

    Directory of Open Access Journals (Sweden)

    Justin Scott Lee

    2015-05-01

    Full Text Available Renal malignancies are common in children. While the majority of malignant renal masses are secondary to Wilms tumor, it can be challenging to distinguish from more aggressive renal masses. For suspicious renal lesions, it is crucial to ensure prompt diagnosis in order to select the appropriate surgical procedure and treatment. This review article will discuss the common differential diagnosis that can be encountered when evaluating a suspicious renal mass in the pediatric population. This includes clear cell sarcoma of the kidney, malignant rhabdoid tumor, renal medullary carcinoma and lymphoma. 

  7. Giant breast tumors: Surgical management of phyllodes tumors, potential for reconstructive surgery and a review of literature

    Directory of Open Access Journals (Sweden)

    McKelvey Michael T

    2008-11-01

    Full Text Available Abstract Background Phyllodes tumors are biphasic fibroepithelial neoplasms of the breast. While the surgical management of these relatively uncommon tumors has been addressed in the literature, few reports have commented on the surgical approach to tumors greater than ten centimeters in diameter – the giant phyllodes tumor. Case presentation We report two cases of giant breast tumors and discuss the techniques utilized for pre-operative diagnosis, tumor removal, and breast reconstruction. A review of the literature on the surgical management of phyllodes tumors was performed. Conclusion Management of the giant phyllodes tumor presents the surgeon with unique challenges. The majority of these tumors can be managed by simple mastectomy. Axillary lymph node metastasis is rare, and dissection should be limited to patients with pathologic evidence of tumor in the lymph nodes.

  8. Featherweight Challenge

    Science.gov (United States)

    Love, Tyler S.; Ryan, Larry

    2012-01-01

    As science, technology education, and engineering programs suffer budget cuts, educators continue to seek cost-effective activities that engage students and reinforce standards. The featherweight challenge is a hands-on activity that challenges students to continually refine their design while not breaking the budget. This activity uses one of the…

  9. Colima: The eleventh entity most competitive of the country

    Directory of Open Access Journals (Sweden)

    José Manuel Orozco Plascencia

    2008-03-01

    Full Text Available According to the I Report of the State Competitiveness 2006, the State of Colima is considered to be the eleventh federal entity more competitive of the country. Number obtained in the favorable results in the national ranking of competitiveness, due to it got a third position to have with a System of Rights Reliable and Objective, besides it got three fifth positions: Sustainable Management of the Environment, Market of Efficient Factors and Precursor Sectors of the World Class, besides of a eighth position to count on a Dynamic Economic and Stables Indicators. Nevertheless, there are some indicators that showed unfavorable results for the entity, for instance, Colima got the 30th place in the factor of Achievement of the International Relations, the 27th position to count on a bad Political and Functional System, and the 24th place to have an Efficient and Effective Government. On average of the sectorial competitiveness, the Pharmaceutical and High-Tech sector holds the fifth position in the national ranking, in order to the priorities for the location of the business investment; the Manufactures are located in the sixth Place; the Textile sector in the eighth, and the more straggler ones like the Agribusiness and Tourism in the ninth position, respectively. Finally, the sensitivity of the investments above an increase of 10% relative to the 120 quantitative variables that revealed that Colima could pass from the eleventh to the third position, this like a result to increase its investment in 3,228 million of pesos for the entity, or increase in 30% the amount per capita for each member of the PEA, equivalent to 12,300 pesos average for employee.

  10. Lobodontia: Genetic entity with specific pattern of dental dysmorphology.

    Science.gov (United States)

    Skrinjaric, Tomislav; Gorseta, Kristina; Skrinjaric, Ilija

    2016-01-01

    A characteristic pattern of dental anomalies including cone-shaped premolars, multitubercular molar crowns, pyramidal molar roots with single root canals, shovel-shaped incisors with palatal invaginations and hypodontia usually described as lobodontia was recognised as a separate entity. Only a few family reports on this condition have been published until now. The prevalence of the condition is estimated to be less than 1:1000,000. In the present paper we tried to delineate and clarify some additional aspects of this rare genetic entity in three families with 17 affected members. This represents the largest number of cases recorded since now. The analyses of dental morphology, crown-size profile patterns, pedigree analyses, and analyses of digitopalmar dermatoglyphics were performed in 7 examined patients. Crown-size profile pattern was calculated for seven patients and compared with standards for the Croatian population. The most striking features of the condition are conical premolars, tritubercular canines, single pyramidal molar roots, multitubercular molar crowns and invaginated upper incisors. A considerable reduction of crown-size was observed for all premolars, particularly in mandible. The alveolar process in the premolar region was hypoplastic and thin in all patients studied. Gender ratio of affected individuals was approximately M1:F1. Our data suggest that the prevalence of this condition is less than 1:300,000 in the Croatian population, which is considerably higher than previously reported in the literature. The analysis of the anomaly in all the families showed a slight variability in the clinical picture and autosomal dominant (AD) mode of inheritance. It could be concluded that this rare condition described as lobodontia represents a true genetic entity which follows AD mode of inheritance and displays variability in its expression.

  11. Tumor-derived circulating endothelial cell clusters in colorectal cancer.

    KAUST Repository

    Cima, Igor

    2016-06-29

    Clusters of tumor cells are often observed in the blood of cancer patients. These structures have been described as malignant entities for more than 50 years, although their comprehensive characterization is lacking. Contrary to current consensus, we demonstrate that a discrete population of circulating cell clusters isolated from the blood of colorectal cancer patients are not cancerous but consist of tumor-derived endothelial cells. These clusters express both epithelial and mesenchymal markers, consistent with previous reports on circulating tumor cell (CTC) phenotyping. However, unlike CTCs, they do not mirror the genetic variations of matched tumors. Transcriptomic analysis of single clusters revealed that these structures exhibit an endothelial phenotype and can be traced back to the tumor endothelium. Further results show that tumor-derived endothelial clusters do not form by coagulation or by outgrowth of single circulating endothelial cells, supporting a direct release of clusters from the tumor vasculature. The isolation and enumeration of these benign clusters distinguished healthy volunteers from treatment-naïve as well as pathological early-stage (≤IIA) colorectal cancer patients with high accuracy, suggesting that tumor-derived circulating endothelial cell clusters could be used as a means of noninvasive screening for colorectal cancer. In contrast to CTCs, tumor-derived endothelial cell clusters may also provide important information about the underlying tumor vasculature at the time of diagnosis, during treatment, and throughout the course of the disease.

  12. Tumor bioengineering using a transglutaminase crosslinked hydrogel.

    Directory of Open Access Journals (Sweden)

    Josephine Y Fang

    Full Text Available Development of a physiologically relevant 3D model system for cancer research and drug development is a current challenge. We have adopted a 3D culture system based on a transglutaminase-crosslinked gelatin gel (Col-Tgel to mimic the tumor 3D microenvironment. The system has several unique advantages over other alternatives including presenting cell-matrix interaction sites from collagen-derived peptides, geometry-initiated multicellular tumor spheroids, and metabolic gradients in the tumor microenvironment. Also it provides a controllable wide spectrum of gel stiffness for mechanical signals, and technical compatibility with imaging based screening due to its transparent properties. In addition, the Col-Tgel provides a cure-in-situ delivery vehicle for tumor xenograft formation in animals enhancing tumor cell uptake rate. Overall, this distinctive 3D system could offer a platform to more accurately mimic in vivo situations to study tumor formation and progression both in vitro and in vivo.

  13. Paragonimus westermani infection in lung: A confounding diagnostic entity

    Directory of Open Access Journals (Sweden)

    Shivani Kalhan

    2015-01-01

    Full Text Available Paragonimiasis is a food-borne parasitic zoonosis caused by the genus Paragonimus. Fresh water snails, crabs, and crayfish are the first and second intermediate hosts, respectively. Humans acquire this infection by ingesting uncooked/undercooked crustaceans. Laboratory diagnosis of Paragonimiasis is done by demonstration of ova in the sputum/feces/pleural fluid or by serology. A case of pulmonary Paragonimiasis is presented herewith; the patient having been diagnosed with pulmonary tuberculosis earlier. The aim of this presentation is to highlight this entity so that it is considered in the differential diagnosis in a case of hemoptysis.

  14. Paragonimus westermani infection in lung: A confounding diagnostic entity

    Science.gov (United States)

    Kalhan, Shivani; Sharma, Pankaj; Sharma, Sonia; Kakria, Neha; Dudani, Sharmila; Gupta, Anshu

    2015-01-01

    Paragonimiasis is a food-borne parasitic zoonosis caused by the genus Paragonimus. Fresh water snails, crabs, and crayfish are the first and second intermediate hosts, respectively. Humans acquire this infection by ingesting uncooked/undercooked crustaceans. Laboratory diagnosis of Paragonimiasis is done by demonstration of ova in the sputum/feces/pleural fluid or by serology. A case of pulmonary Paragonimiasis is presented herewith; the patient having been diagnosed with pulmonary tuberculosis earlier. The aim of this presentation is to highlight this entity so that it is considered in the differential diagnosis in a case of hemoptysis. PMID:25983414

  15. Object-Relational Management of Multiply Represented Geographic Entities

    DEFF Research Database (Denmark)

    Friis-Christensen, Anders; Jensen, Christian Søndergaard

    2003-01-01

    by introducing a multiple representation management system (MRMS), the schema of which includes rules that specify how to identify representations of the same entity, rules that specify consistency requirements, and rules used to restore consistency when necessary. In this paper, we demonstrate by means...... of a prototype and a realworld case study that it is possible to implement a multiple representation schema language on top of an object-relational database management system. Specifically, it is demonstrated how it is possible to map the constructs of the language used for specifying the multiple representation...

  16. Polymicrobial community-acquired pneumonia: An emerging entity.

    Science.gov (United States)

    Cillóniz, Catia; Civljak, Rok; Nicolini, Antonello; Torres, Antoni

    2016-01-01

    Polymicrobial aetiology in community-acquired pneumonia (CAP) is more common than previously recognized. This growing new entity can influence inflammation, host immunity and disease outcomes in CAP patients. However, the true incidence is complicated to determine and probably underestimated due mainly to many cases going undetected, particularly in the outpatient setting, as the diagnostic yield is restricted by the sensitivity of currently available microbiologic tests and the ability to get certain types of clinical specimens. The observed rate of polymicrobial cases may also lead to new antibiotic therapy considerations. In this review, we discuss the pathogenesis, microbial interactions in pneumonia, epidemiology, biomarkers and antibiotic therapy for polymicrobial CAP.

  17. A rare entity in adults: Bilateral Hutch diverticulum with calculi.

    Science.gov (United States)

    Telli, Onur; Guclu, Adil Gucal; Haciyev, Perviz; Burgu, Berk; Gogus, Cagatay

    2015-01-01

    Congenital bladder diverticulum (CBD) is a very uncommon entity in adults. CBD could be unilateral or bilateral and is caused by a congenital weakness in the bladder musculature. CBD is differentiated from the paraureteral or Hutch type of diverticula. A 42-year-old male presented with bilateral Hutch diverticulum and multiple diverticulum calculus on intravenous pyelography. Cystoscopy revealed bladder diverticulum just medial to the left ureteral orifice with multiple calculi; the patient successfully underwent endoscopic laser cystolithotripsy with resolution of his urinary tract infection. To the best of our knowledge, this is the first case report presenting stone formation of CBD in an adult. PMID:26029313

  18. Cold agglutinin disease in sepsis: A rare entity

    Science.gov (United States)

    Garg, Ravinder; Kukar, Neetu; Bajwa, Sukhminder Jit Singh; Kaur, Shaminder

    2015-01-01

    Cold agglutinin disease (CAgD) is a type of autoimmune hemolytic anemia which generally occurs in adults and is characterized by the presence of IgM antibodies directed against polysaccharide antigens on red blood cell surface. A 16-year-old male, having clinical picture of sepsis and anemia, presented to the Emergency Department of our Institute in an Hemodynamically unstable condition. Investigation profile revealed hemolysis due to CAgD, which responded to corticosteroids, antibiotics and supportive treatment. This case highlights the importance of recognizing this entity in such type of cases presenting with sepsis and anemia. PMID:26229347

  19. Entity Framework技术及其应用

    Institute of Scientific and Technical Information of China (English)

    姚远; 胡文俊; 余泽伟; 黄玉兰

    2015-01-01

    Entity Framework(简称EF)是微软推出LINQ to SQL后的新一代ORM技术.目前企业级应用软件开发均采用层次逻辑架构,重点讨论基于.NET的ORM技术变迁,分析EF框架的EDM三部分映射文件,并通过EDM工具的DataBase First方式生成实体类和映射文件,完成数据访问及实例.

  20. Pineal anlage tumour - a rare entity with divergent histology.

    Science.gov (United States)

    Ahuja, Arvind; Sharma, Mehar Chand; Suri, Vaishali; Sarkar, Chitra; Sharma, B S; Garg, Ajay

    2011-06-01

    Pineal anlage tumour is a rare tumour of the pineal gland that is not listed in the 2007 World Health Organization classification of tumours of the central nervous system. Pineal anlage has been defined as a primary pineal tumour with both neuroepithelial and ectomesenchymal differentiation but without endodermal differentiation. We report a pineal anlage tumour in a 4-month-old boy, the youngest patient reported with this rare tumour, with a brief review of the literature. Clinicians and neuropathologists should be aware of this entity as it is likely to be misdiagnosed as a teratoma or a melanocytic tumour of the central nervous system.

  1. Functionalization of polydopamine coated magnetic nanoparticles with biological entities

    Science.gov (United States)

    Mǎgeruşan, Lidia; Mrówczyński, Radosław; Turcu, Rodica

    2015-12-01

    New hybrid materials, obtained through introduction of cysteine, lysine and folic acid as biological entities into polydopamine-coated magnetite nanoparticles, are reported. The syntheses are straight forward and various methods were applied for structural and morphological characterization of the resulting nanoparticles. XPS proved a very powerful tool for surface chemical analysis and it evidences the functionalization of polydopamine coated magnetite nanoparticles. The superparamagnetic behavior and the high values of saturation magnetization recommend all products for further application where magnetism is important for targeting, separation, or heating by alternative magnetic fields.

  2. Radiation-induced nitric oxide mitigates tumor hypoxia and radioresistance in a murine SCCVII tumor model

    International Nuclear Information System (INIS)

    Highlights: •IR-induced NO increased tissue perfusion and pO2. •IR increased NO production in tumors without changes in the mRNA and protein levels of NOS isoforms. •NOS activity assay showed that IR upregulated eNOS activity in tumors. •IR-induced NO decreased tumor hypoxia and altered tumor radiosensitivity. -- Abstract: Tumor hypoxia, which occurs mainly as a result of inadequate tissue perfusion in solid tumors, is a well-known challenge for successful radiotherapy. Recent evidence suggests that ionizing radiation (IR) upregulates nitric oxide (NO) production and that IR-induced NO has the potential to increase intratumoral circulation. However, the kinetics of NO production and the responsible isoforms for NO synthase in tumors exposed to IR remain unclear. In this study, we aimed to elucidate the mechanism by which IR stimulates NO production in tumors and the effect of IR-induced NO on tumor radiosensitivity. Hoechst33342 perfusion assay and electron spin resonance oxymetry showed that IR increased tissue perfusion and pO2 in tumor tissue. Immunohistochemical analysis using two different hypoxic probes showed that IR decreased hypoxic regions in tumors; treatment with a nitric oxide synthase (NOS) inhibitor, L-NAME, abrogated the effects of IR. Moreover, IR increased endothelial NOS (eNOS) activity without affecting its mRNA or protein expression levels in SCCVII-transplanted tumors. Tumor growth delay assay showed that L-NAME decreased the anti-tumor effect of fractionated radiation (10 Gy × 2). These results suggested that IR increased eNOS activity and subsequent tissue perfusion in tumors. Increases in intratumoral circulation simultaneously decreased tumor hypoxia. As a result, IR-induced NO increased tumor radiosensitivity. Our study provides a new insight into the NO-dependent mechanism for efficient fractionated radiotherapy

  3. Radiation-induced nitric oxide mitigates tumor hypoxia and radioresistance in a murine SCCVII tumor model

    Energy Technology Data Exchange (ETDEWEB)

    Nagane, Masaki, E-mail: nagane@vetmed.hokudai.ac.jp [Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo (Japan); Yasui, Hironobu, E-mail: yassan@vetmed.hokudai.ac.jp [Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo (Japan); Yamamori, Tohru, E-mail: yamamorit@vetmed.hokudai.ac.jp [Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo (Japan); Zhao, Songji, E-mail: zsi@med.hokudai.ac.jp [Department of Tracer Kinetics and Bioanalysis, Graduate School of Medicine, Hokkaido University, Sapporo (Japan); Kuge, Yuji, E-mail: kuge@med.hokudai.ac.jp [Central Institute of Isotope Science, Hokkaido University, Sapporo (Japan); Tamaki, Nagara, E-mail: natamaki@med.hokudai.ac.jp [Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Sapporo (Japan); Kameya, Hiromi, E-mail: kameya@affrc.go.jp [Food Safety Division, National Food Research Institute, Tsukuba (Japan); Nakamura, Hideo, E-mail: naka@science-edu.org [Department of Chemistry, Hokkaido University of Education, Hakodate (Japan); Fujii, Hirotada, E-mail: hgfujii@sapmed.ac.jp [Center for Medical Education, Sapporo Medical University, Sapporo (Japan); Inanami, Osamu, E-mail: inanami@vetmed.hokudai.ac.jp [Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo (Japan)

    2013-08-02

    Highlights: •IR-induced NO increased tissue perfusion and pO{sub 2}. •IR increased NO production in tumors without changes in the mRNA and protein levels of NOS isoforms. •NOS activity assay showed that IR upregulated eNOS activity in tumors. •IR-induced NO decreased tumor hypoxia and altered tumor radiosensitivity. -- Abstract: Tumor hypoxia, which occurs mainly as a result of inadequate tissue perfusion in solid tumors, is a well-known challenge for successful radiotherapy. Recent evidence suggests that ionizing radiation (IR) upregulates nitric oxide (NO) production and that IR-induced NO has the potential to increase intratumoral circulation. However, the kinetics of NO production and the responsible isoforms for NO synthase in tumors exposed to IR remain unclear. In this study, we aimed to elucidate the mechanism by which IR stimulates NO production in tumors and the effect of IR-induced NO on tumor radiosensitivity. Hoechst33342 perfusion assay and electron spin resonance oxymetry showed that IR increased tissue perfusion and pO{sub 2} in tumor tissue. Immunohistochemical analysis using two different hypoxic probes showed that IR decreased hypoxic regions in tumors; treatment with a nitric oxide synthase (NOS) inhibitor, L-NAME, abrogated the effects of IR. Moreover, IR increased endothelial NOS (eNOS) activity without affecting its mRNA or protein expression levels in SCCVII-transplanted tumors. Tumor growth delay assay showed that L-NAME decreased the anti-tumor effect of fractionated radiation (10 Gy × 2). These results suggested that IR increased eNOS activity and subsequent tissue perfusion in tumors. Increases in intratumoral circulation simultaneously decreased tumor hypoxia. As a result, IR-induced NO increased tumor radiosensitivity. Our study provides a new insight into the NO-dependent mechanism for efficient fractionated radiotherapy.

  4. Rosette forming glioneuronal tumor of the fourth ventricle in squash cytology smear

    Directory of Open Access Journals (Sweden)

    Amita Radhakrishnan Nair

    2014-01-01

    Full Text Available Rosette forming glioneuronal tumor (RGNT is a recently recognized and extremely rare glioneuronal tumor occurring in the fourth ventricle. It is crucial for the cytopathologist to be aware of this entity as it can be easily mistaken for more common neoplasms occurring at this site. We present here the cytology of such a rare case of RGNT that was misdiagnosed as ependymoma. The varying cytological features of this entity, as well as the common diagnostic difficulties encountered in cytology, are highlighted in this report.

  5. Entity Framework 4.0 Recipes A Problem-solution Approach

    CERN Document Server

    Tenny, L

    2010-01-01

    Entity Framework 4.0 Recipes provides an exhaustive collection of ready-to-use code solutions for Microsoft's Entity Framework, Microsoft's vision for the future of data access. Entity Framework is a model-centric data access platform with an ocean of new concepts and patterns for developers to learn. With this book, you will learn the core concepts of Entity Framework through a broad range of clear and concise solutions to everyday data access tasks. Armed with this experience, you will be ready to dive deep into Entity Framework, experiment with new approaches, and develop ways to solve even

  6. Diagnostic Challenges in the Fine Needle Aspiration Biopsy of Chronic Sclerosing Sialadenitis (Küttner's Tumor) in the Context of Head and Neck Malignancy: A Series of 4 Cases.

    Science.gov (United States)

    Leon, Marino E; Santosh, Neetha; Agarwal, Amit; Teknos, Theodoros N; Ozer, Enver; Iwenofu, O Hans

    2016-09-01

    Chronic sclerosing sialadenitis (CSS) is a benign chronic inflammatory condition of the salivary gland. Clinically, CSS patients may present with a neck mass, often suggesting a neoplastic process. Fine-needle aspiration (FNA) is frequently used to evaluate these lesions. We present a series of 4 patients with CSS, in whom all but one had history of squamous cell carcinoma. The previous diagnosis of malignancy appeared to influence the interpretation of the cytologic preparations. Four patients who had undergone resection of a neck nodule that eventually was diagnosed as CSS were identified. FNA was performed in all 4 cases, and the final cytologic diagnosis in these cases included squamous cell carcinoma, basaloid neoplasm, and salivary gland neoplasm. During intraoperative consultation, the lesions were identified as benign, atrophic salivary gland with chronic inflammation, or sialadenitis with atypical glands. All resected specimens were submitted for histopathological examination and were considered diagnostic for CSS. CSS is a potential pitfall in the FNA interpretation of salivary gland lesions, especially if there is a previous history of head and neck malignancy. Awareness of this entity, adherence to strict cytologic criteria, and careful clinicopathologic correlation are helpful in preventing misinterpretation and unnecessary surgical intervention. PMID:26909791

  7. Cystic Meningioma Masquerading as a Metastatic Tumor: A Case Report.

    Science.gov (United States)

    Ramanathan, Nithya; Kamaruddin, Khairul Azmi; Othman, Aizzat; Mustafa, Fadhli; Awang, Mohamed Saufi

    2016-05-01

    Cystic meningioma is a rare form of intracranial meningioma. Meningiomas are typically solid tumors but may rarely have cystic components. The diagnosis of cystic meningioma is clinically challenging as the finding of multiple intra-axial tumors, including metastatic tumors, is relatively common. We report a case of cystic meningioma initially diagnosed as a metastatic tumor from a recurrence of acute lymphoid leukemia. However, postoperative histopathological examination demonstrated an atypical meningioma. PMID:27418876

  8. Challenges to the Jordanian Electronic Government Initiative

    OpenAIRE

    Ala M. Abu-Samaha; Yara Abdel Samad

    2014-01-01

    This paper aims to present a number of key challenges to the Jordanian Electronic Government Initiative as a precursor to embracing mobile government (the future electronic governmental service provision). The first wave of electronic governmental services was delivered through the web as the sole communication channel. Despite the limited success of a small number of governmental entities to utilise such a communication channel, the very limited penetration of the Internet in Jordan has damp...

  9. Imaging Findings of Scrotal Tumors in Children: A Pictorial Essay

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Myung Hee [Kang-Dong Hospital, Busan (Korea, Republic of); Kim, Jee Eun [Gachon University, Gil Hospital, Incheon (Korea, Republic of); Kim, Ji Hye [Sungkyunkwan University, Samsung Medical Center, Changwon (Korea, Republic of); Yang, Dal Mo [Kyung Hee University Hospital at Gangdong, Seoul (Korea, Republic of)

    2011-12-15

    The diagnosis of scrotal tumors in children can be challenging because of the rarity, vague symptoms, and varied imaging features of the tumors. The pathology and frequency of scrotal tumors that occur in children are different from tumors that arise in adults. In this pictorial essay, we illustrate the imaging findings of scrotal tumors in children with pathological correlations. In addition, we present the clinical manifestations that are valuable for a differential diagnosis. Familiarity with the imaging findings and clinical manifestations of pediatric scrotal tumors may be helpful in making an accurate diagnosis and providing proper patient management

  10. Medicare Program: Expanding Uses of Medicare Data by Qualified Entities. Final rule.

    Science.gov (United States)

    2016-07-01

    This final rule implements requirements under Section 105 of the Medicare Access and CHIP Reauthorization Act of 2015 that expand how qualified entities may use and disclose data under the qualified entity program to the extent consistent with applicable program requirements and other applicable laws, including information, privacy, security and disclosure laws. This rule also explains how qualified entities may create non-public analyses and provide or sell such analyses to authorized users, as well as how qualified entities may provide or sell combined data, or provide Medicare claims data alone at no cost, to certain authorized users. In addition, this rule implements certain privacy and security requirements, and imposes assessments on qualified entities if the qualified entity or the authorized user violates the terms of a data use agreement required by the qualified entity program.

  11. Green Synthesis of Metallic Nanoparticles via Biological Entities

    Directory of Open Access Journals (Sweden)

    Monaliben Shah

    2015-10-01

    Full Text Available Nanotechnology is the creation, manipulation and use of materials at the nanometre size scale (1 to 100 nm. At this size scale there are significant differences in many material properties that are normally not seen in the same materials at larger scales. Although nanoscale materials can be produced using a variety of traditional physical and chemical processes, it is now possible to biologically synthesize materials via environment-friendly green chemistry based techniques. In recent years, the convergence between nanotechnology and biology has created the new field of nanobiotechnology that incorporates the use of biological entities such as actinomycetes algae, bacteria, fungi, viruses, yeasts, and plants in a number of biochemical and biophysical processes. The biological synthesis via nanobiotechnology processes have a significant potential to boost nanoparticles production without the use of harsh, toxic, and expensive chemicals commonly used in conventional physical and chemical processes. The aim of this review is to provide an overview of recent trends in synthesizing nanoparticles via biological entities and their potential applications.

  12. Software Engineering Support Activities for Very Small Entities

    Science.gov (United States)

    Ribaud, Vincent; Saliou, Philippe; O'Connor, Rory V.; Laporte, Claude Y.

    The emerging ISO/IEC 29110 standard Lifecycle profiles for Very Small Entities has at its core a Management and Engineering Guides which is targeted at very small entity (enterprise, organization, department or project) having up to 25 people, to assist them unlock the potential benefits of using standards which are specifically designed to address there needs. The developers of the standard, ISO/IEC JCT1/SC7 Working Group 24 (WG24), recommend the use of pilot projects as a mean to trial the adoption of the new International standard in small organisations. Accordingly an ISO/IEC 29110 pilot project has been established between the Software Engineering group of Brest University and a 14 person company with the aim of establishing an engineering discipline for a new web-based project. This paper details the lessons learned from the pilot project and based on our experiences with using ISO/IEC 29110 we identify a potential deficiency and accordingly propose new process area, "Infrastructure and Support" for include in the future evolution of ISO/IEC 29110 Process Profiles.

  13. Determinants of Voluntary Audit in Micro-Entities : A qualitative study of micro-entities in Skellefteå

    OpenAIRE

    Schöps, Franziska; Persson, Elin

    2012-01-01

    Abstract Smaller companies have less manpower then larger companies to manage administrative tasks. EU has made it possible for member states to reduce the accounting and audit requirements for small companies and Sweden introduced the option of voluntary audit from the fiscal year of 2011 for micro-entities that do not exceed the threshold values of 3 employees, 3 MSEK turnover and 1.5 MSEK balance sheet total. The values are lower than in other countries with voluntary audit. Due to this, p...

  14. Circulating cell-free mitochondrial DNA as a novel cancer biomarker: opportunities and challenges.

    Science.gov (United States)

    Yu, Man

    2012-10-01

    The unique characteristics of the mitochondrial genome, such as short length, simple molecular structure, and high copy number, have made monitoring aberrant changes of mitochondrial DNA (mtDNA) quantity an interesting molecular tool for early tumor detection with many advantages over the nuclear genome-based methods. Recently, circulating cell-free (ccf) mtDNA in blood has emerged on the platform as a non-invasive diagnostic and prognostic biomarker for many forms of solid tumors. Accumulating evidence demonstrate that plasma or serum ccf mtDNA levels are significantly different between cancer patients and healthy individuals. Furthermore, quantification of ccf mtDNA levels in circulation may assist in identifying patients from cancer-free healthy population. This minireview attempts to summarize our recent findings in this very promising field of cancer research. The potential technical challenges that we have encountered during the quantitative analysis of ccf mtDNA and mtDNA in general are also briefly discussed. Prospective studies with a larger cohort of patients in various cancer entities are beneficial to precisely define the clinical importance of assessing the ccf mtDNA amount for diagnosing and tracking malignant diseases and their progression.

  15. Carotid body tumor: a 25-year experience.

    Science.gov (United States)

    Metheetrairut, Choakchai; Chotikavanich, Chanticha; Keskool, Phawin; Suphaphongs, Nit

    2016-08-01

    Carotid body tumor is an uncommon hypervascular benign tumor in the head and neck region. It usually presents as a slow growing mass at the carotid bifurcation. Because of the high rate of neurovascular complications, resection of this tumor is considered challenging for otolaryngologists. Between 1988 and 2013, 40 carotid body tumors from 38 patients were diagnosed and underwent resection at Siriraj Hospital (25 female and 13 male patients). Their age ranged from 15 to 59 years. Seven patients had bilateral tumors simultaneously whereas six cases had familial history of carotid body tumor. Carotid angiography was performed in 29 cases; other additional diagnostic studies included CT scan, MRI, and MRA to detect the widening of carotid bifurcation, its extension, and multifocal tumors. All diagnosed tumors were successfully removed. However, internal carotid artery and carotid bifurcation were injured in 11 cases (27.5 %). Shamblin class III and previous biopsy history were considered risk factors for vascular injury. Postoperative cranial nerves deficit was found in 20 % of the cases and CNS complication occurred in two patients (5 %). There was no surgical mortality. Additionally, upon the mean follow-up period of 36 months, no recurrence or malignant transformation was detected in this study. Multidisciplinary approach, early tumor detection, meticulous preoperative evaluation, and modern vascular surgical technique are the key success factors for tumor removal. PMID:26233244

  16. Chemical named entity recognition in patents by domain knowledge and unsupervised feature learning.

    Science.gov (United States)

    Zhang, Yaoyun; Xu, Jun; Chen, Hui; Wang, Jingqi; Wu, Yonghui; Prakasam, Manu; Xu, Hua

    2016-01-01

    Medicinal chemistry patents contain rich information about chemical compounds. Although much effort has been devoted to extracting chemical entities from scientific literature, limited numbers of patent mining systems are publically available, probably due to the lack of large manually annotated corpora. To accelerate the development of information extraction systems for medicinal chemistry patents, the 2015 BioCreative V challenge organized a track on Chemical and Drug Named Entity Recognition from patent text (CHEMDNER patents). This track included three individual subtasks: (i) Chemical Entity Mention Recognition in Patents (CEMP), (ii) Chemical Passage Detection (CPD) and (iii) Gene and Protein Related Object task (GPRO). We participated in the two subtasks of CEMP and CPD using machine learning-based systems. Our machine learning-based systems employed the algorithms of conditional random fields (CRF) and structured support vector machines (SSVMs), respectively. To improve the performance of the NER systems, two strategies were proposed for feature engineering: (i) domain knowledge features of dictionaries, chemical structural patterns and semantic type information present in the context of the candidate chemical and (ii) unsupervised feature learning algorithms to generate word representation features by Brown clustering and a novel binarized Word embedding to enhance the generalizability of the system. Further, the system output for the CPD task was yielded based on the patent titles and abstracts with chemicals recognized in the CEMP task.The effects of the proposed feature strategies on both the machine learning-based systems were investigated. Our best system achieved the second best performance among 21 participating teams in CEMP with a precision of 87.18%, a recall of 90.78% and aF-measure of 88.94% and was the top performing system among nine participating teams in CPD with a sensitivity of 98.60%, a specificity of 87.21%, an accuracy of 94.75%, a

  17. Chemical named entity recognition in patents by domain knowledge and unsupervised feature learning.

    Science.gov (United States)

    Zhang, Yaoyun; Xu, Jun; Chen, Hui; Wang, Jingqi; Wu, Yonghui; Prakasam, Manu; Xu, Hua

    2016-01-01

    Medicinal chemistry patents contain rich information about chemical compounds. Although much effort has been devoted to extracting chemical entities from scientific literature, limited numbers of patent mining systems are publically available, probably due to the lack of large manually annotated corpora. To accelerate the development of information extraction systems for medicinal chemistry patents, the 2015 BioCreative V challenge organized a track on Chemical and Drug Named Entity Recognition from patent text (CHEMDNER patents). This track included three individual subtasks: (i) Chemical Entity Mention Recognition in Patents (CEMP), (ii) Chemical Passage Detection (CPD) and (iii) Gene and Protein Related Object task (GPRO). We participated in the two subtasks of CEMP and CPD using machine learning-based systems. Our machine learning-based systems employed the algorithms of conditional random fields (CRF) and structured support vector machines (SSVMs), respectively. To improve the performance of the NER systems, two strategies were proposed for feature engineering: (i) domain knowledge features of dictionaries, chemical structural patterns and semantic type information present in the context of the candidate chemical and (ii) unsupervised feature learning algorithms to generate word representation features by Brown clustering and a novel binarized Word embedding to enhance the generalizability of the system. Further, the system output for the CPD task was yielded based on the patent titles and abstracts with chemicals recognized in the CEMP task.The effects of the proposed feature strategies on both the machine learning-based systems were investigated. Our best system achieved the second best performance among 21 participating teams in CEMP with a precision of 87.18%, a recall of 90.78% and aF-measure of 88.94% and was the top performing system among nine participating teams in CPD with a sensitivity of 98.60%, a specificity of 87.21%, an accuracy of 94.75%, a

  18. Challenging Identities

    DEFF Research Database (Denmark)

    Keydar, Ceglar; Marin, Manuela; Janik, Allan;

    , cultural, and political practices. Notions of national identity and national politics are challenged by European integration, as well as by increasing demographic heterogeneity due to migration, and migrants experience conflicts of identification stemming from clashes between cultural heritage...

  19. Large gangliocytic paraganglioma of the duodenum:A rare entity

    Institute of Scientific and Technical Information of China (English)

    Alejandra; Gordillo; Hernández; Eduardo; Dominguez-Adame; Lanuza; Auxiliadora; Cano; Matias; Rosario; Perez; Huertas; Katherine; Maria; Gallardo; Rodriguez; Purificacion; Gallinato; Perez; Fernando; Oliva; Mompean

    2015-01-01

    Gangliocytic paragangliomas are rare tumors that almost exclusively occur within the second portion of the duodenum. Although these tumors generally have a benign clinical course, they have the potential to recur or metastasize to regional lymph nodes. The case report presented here describes a 57-year-old female patient with melena, progressive asthenia, anemia, and a mass in the second-third portion of the duodenum that was treated by local excision. The patient was diagnosed with a friable bleeding tumor. The histologic analysis showed that the tumor was a 4 cm gangliocytic paraganglioma without a malignant cell pattern. In the absence of local invasion or distant metastasis, endoscopic resection represents a feasible, curative therapy. Although endoscopic polypectomy is currently considered the treatment of choice, it is not recommended if the size of the tumor is > 3 cm and/or there is active or recent bleeding. Patients diagnosed with a gangliocytic paraganglioma should be closely followed-up for possible local recurrence.

  20. Brain Tumors (For Parents)

    Science.gov (United States)

    ... Story" 5 Things to Know About Zika & Pregnancy Brain Tumors KidsHealth > For Parents > Brain Tumors Print A ... radiation therapy or chemotherapy, or both. Types of Brain Tumors There are many different types of brain ...

  1. Childhood Brain Tumors

    Science.gov (United States)

    Brain tumors are abnormal growths inside the skull. They are among the most common types of childhood ... still be serious. Malignant tumors are cancerous. Childhood brain and spinal cord tumors can cause headaches and ...

  2. Tumors and Pregnancy

    Science.gov (United States)

    Tumors during pregnancy are rare, but they can happen. Tumors can be either benign or malignant. Benign tumors aren't cancer. Malignant ones are. The most common cancers in pregnancy are breast cancer, cervical cancer, lymphoma, and melanoma. ...

  3. Neuroendocrine Tumor: Statistics

    Science.gov (United States)

    ... Tumor > Neuroendocrine Tumor - Statistics Request Permissions Neuroendocrine Tumor - Statistics Approved by the Cancer.Net Editorial Board , 04/ ... the body. It is important to remember that statistics on how many people survive this type of ...

  4. Cyst or tumor in the buccomaxillary region: Review of literature and a case report

    Science.gov (United States)

    Raheel, Syed Ahmed; Kujan, Omar Bashar; Dwedary, Hisham Mohammed Najeeb; Sikander, Mohammed Hilal; Mankar, Sunil; Amrin, M. Nidha

    2015-01-01

    Odontogenic tumors (OTs) include entities of a hamartomatous nature, such as odontoma, benign neoplasms like an adenomatoid odontogenic tumor (AOT), some benign neoplasms are aggressive as in the case of ameloblastoma. The AOT is a rare odontogenic tumor constituting only 3% of all the OT and very often misdiagnosed as an odontogenic cyst. We report a case of an intra-osseous type of AOT occurred in a young 16-year-old female located in the anterior maxilla along with the clinical, radiological, histological features, and literature review related to the tumor affecting the patient. PMID:26538960

  5. Gingival Granular Cell Tumor of the Newborn: A Case Report and Review of Literature

    Directory of Open Access Journals (Sweden)

    Adalat HASANOV

    2011-05-01

    Full Text Available The etiology and histogenesis of granular cell tumor are still debated. Granular cell tumor of the newborn is considered to be a different entity than the adult form of this lesion with different immunohistochemical features. We present a case of a rare gingival granular cell tumor in a newborn and review the literature. Gingival granular cell tumor must be clinically differentiated from teratoma, congenital dermoid cyst, congenital fibrosarcoma, hemangioma, lymphangioma, leiomyoma, rhabdomyoma, heterotopic gastrointestinal cyst, congenital cystic choristoma and congenital lipoma. Surface ulceration or pseudoepitheliomatous hyperplasia may lead to confusion with malignancy.

  6. Cyst or tumor in the buccomaxillary region: Review of literature and a case report.

    Science.gov (United States)

    Raheel, Syed Ahmed; Kujan, Omar Bashar; Dwedary, Hisham Mohammed Najeeb; Sikander, Mohammed Hilal; Mankar, Sunil; Amrin, M Nidha

    2015-08-01

    Odontogenic tumors (OTs) include entities of a hamartomatous nature, such as odontoma, benign neoplasms like an adenomatoid odontogenic tumor (AOT), some benign neoplasms are aggressive as in the case of ameloblastoma. The AOT is a rare odontogenic tumor constituting only 3% of all the OT and very often misdiagnosed as an odontogenic cyst. We report a case of an intra-osseous type of AOT occurred in a young 16-year-old female located in the anterior maxilla along with the clinical, radiological, histological features, and literature review related to the tumor affecting the patient.

  7. Gynecological tumors; Gynaekologische Tumoren

    Energy Technology Data Exchange (ETDEWEB)

    Zimny, M. [Technische Hochschule Aachen (Germany). Klinik fuer Nuklearmedizin; Nitzsche, E.U. [Freiburg Univ. (Germany). Abt. Nuklearmedizin

    2000-09-01

    Early diagnosis and accurate staging of gynecological tumors based on noninvasive imaging remains a challenge. US, CT and MRI lack sensitivity and specificity for diagnosis and staging of primary disease, residual mass and recurrent disease. FDG-PET may add some important diagnostic information, but currently available results from initial studies indicate that it will not replace other staging tools for specific questions to be answered during work-up. (orig.) [German] Fruehdiagnose und korrekte nichtinvasive bildgebende Ausbreitungsdiagnostik von gynaekologischen Tumorerkrankungen sind vorerst weiterhin eine Illusion. US, CT und MRI erreichen bisher keine akzeptable Sensitivitaet und Spezifitaet in der Primaertumordiagnostik, Tumorresiduendiagnostik und Tumorrezidivdiagnostik. Die FDG-PET wird moeglicherweise wichtige Informationen bezueglich Lymphknotenbefall und Fernmetastasierung sowie Rezidivdetektion beitragen koennen, initiale Studienergebnisse zeigen jedoch, dass sie etablierte Staginguntersuchungen gegenwaertig nicht ersetzen kann. (orig.)

  8. Pancreatic pseudocyst or a cystic tumor of the pancreas?

    OpenAIRE

    Mohammad Ezzedien Rabie; Ismail El Hakeem; Mohammad Saad Al Skaini; Ahmad El Hadad; SalimJamil; Mian TahirShah; MahmoudObaid

    2014-01-01

    Pancreatic pseudocysts are the most common cystic lesions of the pancreas and may complicate acute pancreatitis, chronic pancreatitis, or pancreatic trauma. While the majority of acute pseudocysts resolve spontaneously, few may require drainage. On the other hand, pancreatic cystic tumors, which usually require extirpation, may disguise as pseudocysts. Hence, the distinction between the two entities is crucial for a successful outcome. We conducted this study to highlight the fundamental diff...

  9. Myofibroblastic tumor associated to superior vena cava syndrome

    International Nuclear Information System (INIS)

    Inflammatory myofibroblastic tumor (IMT) is an uncommon pathological entity of unknown cause, composed of differentiated myofibroblastic cells accompanied by plasma cells, lymphocytes and eosinophils, which involve extrapulmonary and pulmonary tissues. IMT has an unpredictable clinical course, rarely undergoes malignant transformation. Local invasion and involvement of the mediastinum and hiliar structures are unusual manifestations; however; we reports a case of superior vena cava syndrome and IMT

  10. Enhancement of chemical entity identification in text using semantic similarity validation.

    Directory of Open Access Journals (Sweden)

    Tiago Grego

    Full Text Available With the amount of chemical data being produced and reported in the literature growing at a fast pace, it is increasingly important to efficiently retrieve this information. To tackle this issue text mining tools have been applied, but despite their good performance they still provide many errors that we believe can be filtered by using semantic similarity. Thus, this paper proposes a novel method that receives the results of chemical entity identification systems, such as Whatizit, and exploits the semantic relationships in ChEBI to measure the similarity between the entities found in the text. The method assigns a single validation score to each entity based on its similarities with the other entities also identified in the text. Then, by using a given threshold, the method selects a set of validated entities and a set of outlier entities. We evaluated our method using the results of two state-of-the-art chemical entity identification tools, three semantic similarity measures and two text window sizes. The method was able to increase precision without filtering a significant number of correctly identified entities. This means that the method can effectively discriminate the correctly identified chemical entities, while discarding a significant number of identification errors. For example, selecting a validation set with 75% of all identified entities, we were able to increase the precision by 28% for one of the chemical entity identification tools (Whatizit, maintaining in that subset 97% the correctly identified entities. Our method can be directly used as an add-on by any state-of-the-art entity identification tool that provides mappings to a database, in order to improve their results. The proposed method is included in a freely accessible web tool at www.lasige.di.fc.ul.pt/webtools/ice/.

  11. Enhancement of chemical entity identification in text using semantic similarity validation.

    Science.gov (United States)

    Grego, Tiago; Couto, Francisco M

    2013-01-01

    With the amount of chemical data being produced and reported in the literature growing at a fast pace, it is increasingly important to efficiently retrieve this information. To tackle this issue text mining tools have been applied, but despite their good performance they still provide many errors that we believe can be filtered by using semantic similarity. Thus, this paper proposes a novel method that receives the results of chemical entity identification systems, such as Whatizit, and exploits the semantic relationships in ChEBI to measure the similarity between the entities found in the text. The method assigns a single validation score to each entity based on its similarities with the other entities also identified in the text. Then, by using a given threshold, the method selects a set of validated entities and a set of outlier entities. We evaluated our method using the results of two state-of-the-art chemical entity identification tools, three semantic similarity measures and two text window sizes. The method was able to increase precision without filtering a significant number of correctly identified entities. This means that the method can effectively discriminate the correctly identified chemical entities, while discarding a significant number of identification errors. For example, selecting a validation set with 75% of all identified entities, we were able to increase the precision by 28% for one of the chemical entity identification tools (Whatizit), maintaining in that subset 97% the correctly identified entities. Our method can be directly used as an add-on by any state-of-the-art entity identification tool that provides mappings to a database, in order to improve their results. The proposed method is included in a freely accessible web tool at www.lasige.di.fc.ul.pt/webtools/ice/.

  12. Brenner or non-Brenner′s?: A diagnostic challenge!!

    OpenAIRE

    Samarth Shukla; Neema Acharya; Sourya Acharya; Devendra Rajput; Sunita Vagha

    2012-01-01

    Ovarian tumors are broadly classified into surface epithelial, germ cell, sex cord, and stromal tumors and other rarer special categories under the WHO scheme. The Brenner tumors of the surface epithelial group pose a diagnostic challenge in special context of its histogenesis. We present a case of 46-year-old female with an ovarian mass and ascitis. The surgico-pathological evaluation of gross and microscopic features suggested a malignant Brenner tumor. Transitional cell carcinoma (non-Bren...

  13. Chorioallantoic Membrane Microtumor Model to Study the Mechanisms of Tumor Angiogenesis, Vascular Permeability, and Tumor Cell Intravasation.

    Science.gov (United States)

    Deryugina, Elena I

    2016-01-01

    The mechanisms governing the development of angiogenic blood vessels, which not only deliver the nutrients to growing tumors but also provide the conduits for tumor cell dissemination, are still not fully resolved. The model systems based on the grafting of human tumor cells onto the chorioallantoic membrane (CAM) of the chick embryo offer several advantages to study complex processes underlying tumor angiogenesis and tumor cell dissemination. In particular, the CAM model described here allows for investigation of multiple microtumors as independent entities, thereby greatly facilitating quantification and statistical analyses of tumor neovascularization and cancer spreading. This CAM microtumor system was designed specifically to measure the level of tumor cell intravasation in combination with quantitative analyses of the microarchitecture and permeability of the intratumoral angiogenic blood vessels. By using this newly established microtumor model we have demonstrated the functional involvement of tumor matrix metalloproteinase-1 (MMP-1) and epidermal growth factor receptor (EGFR) in regulating the development of a distinct angiogenic vasculature capable of sustaining tumor cell intravasation and metastasis. PMID:27172961

  14. [Parietal-scar endometriosis after cesarean section: a rare entity].

    Science.gov (United States)

    El Fahssi, Mohammed; Lomdo, Massama; Bounaim, Ahmed; Ali, Abdelmounaim Ait; Sair, Khalid

    2016-01-01

    Wall endometriosis is a rare clinical entity whose pathophysiology remains unclear. It occurs most frequently after gynecologic or obstetric surgery. We report the case of a patient with cyclic pain at the caesarean section scar. Clinical examination showed a 5 cm mass in the right iliac fossa. Tomodensitometry revealed a tissue density mass (45mm on the major axis). Hence, the decision to perform a wide excision of the lesion. Anatomo-pathological examination confirmed the diagnosis of parietal endometriosis. Postoperative sequelae were simple with a follow-up period of 20 months with no recurrence of the mass or of the pain. Our study highlights the characteristics of this disease to allow the health practitioner to understand the importance of diagnosis, of early treatment of this disease as well as of the possibility to prevent it during each gynecologic or obstetric surgery. PMID:27642418

  15. Dysphonic Occupational Syndrome: New Aspects of this Nosological Entity

    Directory of Open Access Journals (Sweden)

    Pontes, Paulo

    2010-09-01

    Full Text Available Introduction: Teachers often have vocal disorders that benefit from preventive measures. Objective: To determine the prevalence of the syndrome in dysphonic teachers and check the evolution of this index with the techniques of primary prevention. Method: We performed a cross-sectional study of teachers in two different periods: in the first 101 teachers and participated in phase 2, 148 teachers. These two groups was administered the questionnaire prepared by the tripartite commission on regulation of the professional voice. Results: The prevalence of the syndrome dysphonic in the first phase was 70.3%, while the second stage was 57.59%. Conclusion: 1st dysphonic the prevalence of the syndrome was significantly decreased with the implementation of preventive and medical control of work organization. 2nd dysphonic syndrome is a new nosological entity. Cross-sectional epidemiological study. Study series.

  16. Hypertrophic cardiomyopathy and ultra-endurance running - two incompatible entities?

    Directory of Open Access Journals (Sweden)

    Wilson Mathew G

    2011-11-01

    Full Text Available Abstract Regular and prolonged exercise is associated with increased left ventricular wall thickness that can overlap with hypertrophic cardiomyopathy (HCM. Differentiating physiological from pathological hypertrophy has important implications, since HCM is the commonest cause of exercise-related sudden cardiac death in young individuals. Most deaths have been reported in intermittent 'start-stop' sports such as football (soccer and basketball. The theory is that individuals with HCM are unable to augment stroke volume sufficiently to meet the demands of endurance sports and are accordingly 'selected-out' of participation in such events. We report the case of an ultra-endurance athlete with 25 years of > 50 km competitive running experience, with genetically confirmed HCM; thereby demonstrating that these can be two compatible entities.

  17. Pseudofolliculitis corporis: a new entity diagnosed by dermoscopy.

    Science.gov (United States)

    Puhan, Manas Ranjan; Sahu, Bharati

    2015-01-01

    Pseudofolliculitis mainly affects the beard area, but it can occur in any area of hair-bearing skin when traumatic methods like shaving or plucking are used to remove the hair. It can be a simple cosmetic problem or a disturbing medical condition for which the dermatologist must be prepared. It can develop in areas of shaving or depilation and has been seen in the pubic region or the axilla, where it is common to find curly hair that emerges at an acute angle. Here, we are reporting a case of pseudofolliculitis over back, termed as pseudofolliculitis corporis. He used to put a pillow behind the back while driving and the pressure caused the pseudofolliculitis. The diagnosis was confirmed by dermoscopy, which is a simple office procedure. Patient was advised to stop using the pillow and improved with topical adapalene and clindamycin gel for 15 days. This entity has not been described in the literature. PMID:25878447

  18. On the Fly Query Entity Decomposition Using Snippets

    CERN Document Server

    Brenes, David J; Garcia, Rodrigo

    2010-01-01

    One of the most important issues in Information Retrieval is inferring the intents underlying users' queries. Thus, any tool to enrich or to better contextualized queries can proof extremely valuable. Entity extraction, provided it is done fast, can be one of such tools. Such techniques usually rely on a prior training phase involving large datasets. That training is costly, specially in environments which are increasingly moving towards real time scenarios where latency to retrieve fresh informacion should be minimal. In this paper an `on-the-fly' query decomposition method is proposed. It uses snippets which are mined by means of a na\\"ive statistical algorithm. An initial evaluation of such a method is provided, in addition to a discussion on its applicability to different scenarios.

  19. Swyer-James-Macleod Syndrome: A Rare Entity.

    Science.gov (United States)

    Singh, Urvinderpal; Vidhu; Aditi; Singh, Kulbir; Singh, Ashrafjit

    2015-01-01

    Swyer-James-MacLeod syndrome is a radiological entity characterised by hyperlucency of one or more lobes or of the entire lung associated with decreased number and diameter of ipsilateral peripheral pulmonary vessels resulting in difficult visibility of the arterial network, and unobstructed bronchial system. We report the case of a 12-year-old girl who presented with chief complaint of pain in the chest. Chest radiograph (postero-anterior view) showed hyperlucent left lung field with increased lung volume and shift of the mediastinum to the right side. Contrast-enhanced computed tomography (CECT) of the chest showed hyperlucency and diminished vascularity in the upper lobe and lingula of left lung with hyperinflation of the pulmonary parenchyma. On the basis of clinical and radiological findings, the patient was diagnosed to have Swyer-James-MacLeod syndrome. PMID:26591973

  20. Semantic Representation of Moving Entities for Enhancing Geographical Information Systems

    Directory of Open Access Journals (Sweden)

    Yuniel E. Proenza Arias

    2013-09-01

    Full Text Available Geographical Information Systems have become useful for fleet control, hurricane tracking, tourism analysis and some other critical fields that include decision making processes. The analysis have been mainly focused on historical movement, movement prediction and motion patterns detection, which have a tremendous impact in traffic analysis, finding locations of interest and most visited places, estimating hurricane damage and so more. Recently, ontology driven GIS have shown to the scientific community the advantages of making semantic analysis based in ontology models. In this work we present the advantages of using ontologies for representing moving entities and enriching information with semantics. We also present some experimental results of using an ontological model and making semantic queries over the laying information, encouraging on several obtained benefits and aiming to state a basis for enhanced ontology driven GIS.

  1. Idiopathic pleuroparenchymal fibroelastosis: description of a novel clinicopathologic entity.

    Science.gov (United States)

    Frankel, Stephen K; Cool, Carlyne D; Lynch, David A; Brown, Kevin K

    2004-12-01

    Between 1996 and 2001, we identified five cases of a unique idiopathic pleuroparenchymal lung disease characterized by a clinical presentation suggestive of a chronic idiopathic interstitial pneumonia, marked pleural and parenchymal radiographic involvement with an upper lobe predominance, and surgical lung biopsy findings that did not fit with any of the currently defined interstitial pneumonias. The pathologic findings included the following: (1) intense fibrosis of the visceral pleura; (2) prominent, homogenous, subpleural fibroelastosis; (3) sparing of the parenchyma distant from the pleura; (4) mild, patchy lymphoplasmacytic infiltrates; and (5) small numbers of fibroblastic foci present at the leading edge of the fibrosis. In this report, we characterize the clinical, radiographic, physiologic, and pathologic findings of this entity, which we term idiopathic pleuroparenchymal fibroelastosis. PMID:15596706

  2. Transitional cell carcinoma of the sinonasal tract: A rare entity

    Directory of Open Access Journals (Sweden)

    Madhumita Mondal

    2015-01-01

    Full Text Available Malignant sinonasal carcinomas are a rare entity comprising less than 1% of all cancers and around 3% of all head and neck malignancies seen in humans. Among these 15-20% are transitional cell carcinoma also known as non keratinizing carcinoma of sinonasal tract. We are reporting the case of a 45 years female with history of nasal obstruction and epistaxis. A contrast enhanced computed tomography (CECT was done which showed mucosal thickening in the right nasal cavity. Endoscopy assisted biopsy was taken which revealed non keratinizing carcinoma (transitional type. Very few reported cases of this type of malignancy was found. A possible reason could be multiple synonyms like cylindrical cell carcinoma, Schneiderian carcinoma and transitional cell carcinoma.

  3. A Variance Based Active Learning Approach for Named Entity Recognition

    Science.gov (United States)

    Hassanzadeh, Hamed; Keyvanpour, Mohammadreza

    The cost of manually annotating corpora is one of the significant issues in many text based tasks such as text mining, semantic annotation and generally information extraction. Active Learning is an approach that deals with reduction of labeling costs. In this paper we proposed an effective active learning approach based on minimal variance that reduces manual annotation cost by using a small number of manually labeled examples. In our approach we use a confidence measure based on the model's variance that reaches a considerable accuracy for annotating entities. Conditional Random Field (CRF) is chosen as the underlying learning model due to its promising performance in many sequence labeling tasks. The experiments show that the proposed method needs considerably fewer manual labeled samples to produce a desirable result.

  4. Intratumoral Pharmacokinetics: Challenges to Nanobiomaterials.

    Science.gov (United States)

    Al-Abd, Ahmed M; Al-Abbasi, Fahad A; Torchilin, Vladimir P

    2015-01-01

    Resistance of solid tumors to treatment is significantly attributed to pharmacokinetic reasons at both cellular and multi-cellular levels. Anticancer agent must be bio-available at the site of action in a cytotoxic concentration to exert its proposed activity. Solid tumor tissue is characterized by high density of vascular bed however; the vast majority of these blood vessels are not functioning. The vast majority of solid tumors can be described as poorly perfused with blood; and anticancer agents need to penetrate/distribute avascularly within solid tumor micro-milieu. Classic pharmacokinetic parameters correlate drug status within central compartment (blood) to all perfused body tissues according to their degree of perfusion. Yet, these classic pharmacokinetic parameters cannot fully elucidate the intratumoral drug penetration/distribution status of anticancer drugs due to the great discrepancies in perfusion between normal and solid tumor tissues. Herein, we will discuss the recently proposed pharmacokinetic parameters that might accurately portray the distribution of anticancer agents within solid tumor micro-milieu. In addition, we will present the new challenges attributed to these new pharmacokinetic parameters towards designing nanobiomaterial drug delivery system. PMID:26027565

  5. Osteoporotic vertebral fracture simulating a spinal tumor: a case report

    Directory of Open Access Journals (Sweden)

    Moscote-Salazar Luis Rafael

    2015-06-01

    Full Text Available Vertebral fractures are a frequent entity, mainly in the thoracolumbar and lumbar spine. In some circumstances the differential diagnosis of vertebral injuries can confuse the physician, since the difference between an osteoporotic vertebral fracture and a fracture secondary to a tumor is not clear. We report the case of a patient with osteoporotic vertebral fracture simulating a spinal tumor, handled by our department of neurosurgery as illustrative experience to guide the approach in those cases, in which the definitive diagnosis is crucial for therapeutic decision making

  6. Tumor information extraction in radiology reports for hepatocellular carcinoma patients

    Science.gov (United States)

    Yim, Wen-wai; Denman, Tyler; Kwan, Sharon W.; Yetisgen, Meliha

    2016-01-01

    Hepatocellular carcinoma (HCC) is a deadly disease affecting the liver for which there are many available therapies. Targeting treatments towards specific patient groups necessitates defining patients by stage of disease. Criteria for such stagings include information on tumor number, size, and anatomic location, typically only found in narrative clinical text in the electronic medical record (EMR). Natural language processing (NLP) offers an automatic and scale-able means to extract this information, which can further evidence-based research. In this paper, we created a corpus of 101 radiology reports annotated for tumor information. Afterwards we applied machine learning algorithms to extract tumor information. Our inter-annotator partial match agreement scored at 0.93 and 0.90 F1 for entities and relations, respectively. Based on the annotated corpus, our sequential labeling entity extraction achieved 0.87 F1 partial match, and our maximum entropy classification relation extraction achieved scores 0.89 and 0. 74 F1 with gold and system entities, respectively. PMID:27570686

  7. Tumor information extraction in radiology reports for hepatocellular carcinoma patients.

    Science.gov (United States)

    Yim, Wen-Wai; Denman, Tyler; Kwan, Sharon W; Yetisgen, Meliha

    2016-01-01

    Hepatocellular carcinoma (HCC) is a deadly disease affecting the liver for which there are many available therapies. Targeting treatments towards specific patient groups necessitates defining patients by stage of disease. Criteria for such stagings include information on tumor number, size, and anatomic location, typically only found in narrative clinical text in the electronic medical record (EMR). Natural language processing (NLP) offers an automatic and scale-able means to extract this information, which can further evidence-based research. In this paper, we created a corpus of 101 radiology reports annotated for tumor information. Afterwards we applied machine learning algorithms to extract tumor information. Our inter-annotator partial match agreement scored at 0.93 and 0.90 F1 for entities and relations, respectively. Based on the annotated corpus, our sequential labeling entity extraction achieved 0.87 F1 partial match, and our maximum entropy classification relation extraction achieved scores 0.89 and 0. 74 F1 with gold and system entities, respectively. PMID:27570686

  8. Concept Extraction Challenge: University of Twente at #MSM2013

    NARCIS (Netherlands)

    Habib, Mena B.; Keulen, van Maurice; Zhu, Zhemin

    2013-01-01

    Twitter messages are a potentially rich source of continuously and instantly updated information. Shortness and informality of such messages are challenges for Natural Language Processing tasks. In this paper we present a hybrid approach for Named Entity Extraction (NEE) and Classification (NEC) for

  9. PARTIAL HYDATIDIFORM MOLE WITH A LIVE FETUS: A RARE ENTITY

    Directory of Open Access Journals (Sweden)

    Mounika Reddy

    2015-07-01

    Full Text Available BACKGROUND : Gestational trophoblastic neoplasia (GTN represents a spectrum of premalignant and malignant diseases that occur after abnormal fertilization. [ 1 ] GTN includes complete hydatidiform mole (CHM, partial hydatidiform mole (PHM, invasive mole, choriocarcinoma, and placental - site trophoblastic tumor (PSTT. CHM and PHM together account for 80% of all cases of GTN.

  10. Maximizing Tumor Immunity With Fractionated Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Schaue, Doerthe, E-mail: dschaue@mednet.ucla.edu [Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA (United States); Ratikan, Josephine A.; Iwamoto, Keisuke S.; McBride, William H. [Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA (United States)

    2012-07-15

    Purpose: Technologic advances have led to increased clinical use of higher-sized fractions of radiation dose and higher total doses. How these modify the pathways involved in tumor cell death, normal tissue response, and signaling to the immune system has been inadequately explored. Here we ask how radiation dose and fraction size affect antitumor immunity, the suppression thereof, and how this might relate to tumor control. Methods and Materials: Mice bearing B16-OVA murine melanoma were treated with up to 15 Gy radiation given in various-size fractions, and tumor growth followed. The tumor-specific immune response in the spleen was assessed by interferon-{gamma} enzyme-linked immunospot (ELISPOT) assay with ovalbumin (OVA) as the surrogate tumor antigen and the contribution of regulatory T cells (Tregs) determined by the proportion of CD4{sup +}CD25{sup hi}Foxp3{sup +} T cells. Results: After single doses, tumor control increased with the size of radiation dose, as did the number of tumor-reactive T cells. This was offset at the highest dose by an increase in Treg representation. Fractionated treatment with medium-size radiation doses of 7.5 Gy/fraction gave the best tumor control and tumor immunity while maintaining low Treg numbers. Conclusions: Radiation can be an immune adjuvant, but the response varies with the size of dose per fraction. The ultimate challenge is to optimally integrate cancer immunotherapy into radiation therapy.

  11. What "helps" tumors evade vascular targeting treatment?

    Institute of Scientific and Technical Information of China (English)

    SI Zhi-chao; LIU Jie

    2008-01-01

    Objective To throw a light on the possible factors which might induce resistance of vascular targeting treatment in tumors by reviewing the recent publications in the field of tumor angiogenesis and vascular targeting treatment.Data sources The data used in this review were mainly from Medline and PubMed for relevant English language articles published from 1971 to January 2008. The search terms were "angiogenesis", "vascular targeting treatment" and "endothelial progenitor cells".Study selection Articles involved in the possible influence factors during angiogenesis and vascular targeting treatment were selected, including angiogenic or anti-angiogenic mechanism, tumor vasculature, tumor cells, cancer stem cells and endothelial progenitor cells.Results As a promising strategy vascular targeting treatment still has experimental and clinical setbacks which may term tumor vasculature's resistance to anti-angiogenesis agents. There are several possible explanations for such a resistance that might account for clinical and preclinical failures of anti-angiogenic treatment against tumor.Proangiogenic effect of hypoxia, normal tumor vasculature, escape of tumor cells and tumor vasculogenesis are included.This review reveals some clues which might be helpful to direct future research in order to remove obstacles to vascular targeting treatment.Conclusions Generally and undoubtedly vascular targeting treatment remains a promising strategy. But we still have to realize the existence of a challenging future. Further research is required to enhance our knowledge of vascular targeting treatment strategy before it could make a more substantial success.

  12. Exploiting tumor epigenetics to improve oncolytic virotherapy

    Directory of Open Access Journals (Sweden)

    Nicole E. Forbes

    2013-09-01

    Full Text Available Oncolytic viruses (OVs comprise a versatile and multi-mechanistic therapeutic platform in the growing arsenal of anticancer biologics. These replicating therapeutics find favorable conditions in the tumor niche, characterized among others by increased metabolism, reduced anti-tumor/antiviral immunity, and disorganized vasculature. Through a self-amplification that is dependent on multiple cancer-specific defects, these agents exhibit remarkable tumor selectivity. With several OVs completing or entering Phase III clinical evaluation, their therapeutic potential as well as the challenges ahead are increasingly clear. One key hurdle is tumor heterogeneity, which results in variations in the ability of tumors to support productive infection by OVs and to induce adaptive anti-tumor immunity. To this end, mounting evidence suggests tumor epigenetics may play a key role. This review will focus on the epigenetic landscape of tumors and how it relates to OV infection. Therapeutic strategies aiming to exploit the epigenetic identity of tumors in order to improve OV therapy are also discussed.

  13. Involvement of Corporate Entities in Waqaf Management: Experiences of Malaysia and Singapore

    OpenAIRE

    Norma Md Saad; Salina Kassim; Zarinah Hamid

    2013-01-01

    The main focus of this paper is to examine the corporate management models of selected waqaf entities in Malaysia and Singapore. The waqaf entities involved in this study include two corporate waqaf institutions namely Kumpulan Waqaf An-Nur Berhad and IIUM Endowment Fund and one corporate waqaf institution in Singapore namely Warees Private Limited, Majlis Ugama Islam Singapore. It also analyzes how these waqaf entities finance the development of their waqaf property, especially land. Such a ...

  14. Dynamic perfusion CT in brain tumors.

    Science.gov (United States)

    Yeung, Timothy Pok Chi; Bauman, Glenn; Yartsev, Slav; Fainardi, Enrico; Macdonald, David; Lee, Ting-Yim

    2015-12-01

    Dynamic perfusion CT (PCT) is an imaging technique for assessing the vascular supply and hemodynamics of brain tumors by measuring blood flow, blood volume, and permeability-surface area product. These PCT parameters provide information complementary to histopathologic assessments and have been used for grading brain tumors, distinguishing high-grade gliomas from other brain lesions, differentiating true progression from post-treatment effects, and predicting prognosis after treatments. In this review, the basic principles of PCT are described, and applications of PCT of brain tumors are discussed. The advantages and current challenges, along with possible solutions, of PCT are presented.

  15. Logistical challenges

    Directory of Open Access Journals (Sweden)

    Steve Matthews

    2005-07-01

    Full Text Available The impact of the Asian tsunami was unprecedented and the logistical challenges of meeting the needs of those affected were enormous. Had the tsunami happened even five years ago, World Vision would not have been able to respond nearly as effectively as it did.

  16. Ethical Challenges

    Science.gov (United States)

    Morris, Michael

    2004-01-01

    All evaluators face the challenge of striving to adhere to the highest possible standards of ethical conduct. Translating the AEA's Guiding Principles and the Joint Committee's Program Evaluation Standards into everyday practice, however, can be a complex, uncertain, and frustrating endeavor. Moreover, acting in an ethical fashion can require…

  17. Archiving challenges

    OpenAIRE

    Ringersma, J.

    2010-01-01

    Teaching slides on: What is a digital archive? Parties involved in digital archiving Archiving challenges organization of data coherence and persistency access and safety Language archiving software Different users, different needs For: Saami Language Documentation and Revitalization. Winter school, Bodø, Norway

  18. Information Asymmetries and Their Challenge to International Broadcasting

    Directory of Open Access Journals (Sweden)

    Monroe Edwin Price

    2016-05-01

    Full Text Available Dramatic symmetries in strategies and techniques of persuasion create challenges to the functioning of established actors in the global media ecology, including international broadcasters. This essay articulates an adaptation of the concept of asymmetric warfare to the field of propaganda, persuasion and recruitment. It examines the particular challenge of certain asymmetric entrants, including ISIS and categorizes how the more traditional entities and government institutions react to these new entrants in markets for loyalties.

  19. Information Asymmetries and Their Challenge to International Broadcasting

    OpenAIRE

    Monroe Edwin Price

    2016-01-01

    Dramatic symmetries in strategies and techniques of persuasion create challenges to the functioning of established actors in the global media ecology, including international broadcasters. This essay articulates an adaptation of the concept of asymmetric warfare to the field of propaganda, persuasion and recruitment. It examines the particular challenge of certain asymmetric entrants, including ISIS and categorizes how the more traditional entities and government institutions react to these n...

  20. Anatomical entity recognition with a hierarchical framework augmented by external resources.

    Directory of Open Access Journals (Sweden)

    Yan Xu

    Full Text Available References to anatomical entities in medical records consist not only of explicit references to anatomical locations, but also other diverse types of expressions, such as specific diseases, clinical tests, clinical treatments, which constitute implicit references to anatomical entities. In order to identify these implicit anatomical entities, we propose a hierarchical framework, in which two layers of named entity recognizers (NERs work in a cooperative manner. Each of the NERs is implemented using the Conditional Random Fields (CRF model, which use a range of external resources to generate features. We constructed a dictionary of anatomical entity expressions by exploiting four existing resources, i.e., UMLS, MeSH, RadLex and BodyPart3D, and supplemented information from two external knowledge bases, i.e., Wikipedia and WordNet, to improve inference of anatomical entities from implicit expressions. Experiments conducted on 300 discharge summaries showed a micro-averaged performance of 0.8509 Precision, 0.7796 Recall and 0.8137 F1 for explicit anatomical entity recognition, and 0.8695 Precision, 0.6893 Recall and 0.7690 F1 for implicit anatomical entity recognition. The use of the hierarchical framework, which combines the recognition of named entities of various types (diseases, clinical tests, treatments with information embedded in external knowledge bases, resulted in a 5.08% increment in F1. The resources constructed for this research will be made publicly available.

  1. Entropy and graph based modelling of document coherence using discourse entities

    DEFF Research Database (Denmark)

    Petersen, Casper; Lioma, Christina; Simonsen, Jakob Grue;

    2015-01-01

    We present two novel models of document coherence and their application to information retrieval (IR). Both models approximate document coherence using discourse entities, e.g. the subject or object of a sentence. Our first model views text as a Markov process generating sequences of discourse...... entities (entity n-grams); we use the entropy of these entity n-grams to approximate the rate at which new information appears in text, reasoning that as more new words appear, the topic increasingly drifts and text coherence decreases. Our second model extends the work of Guinaudeau & Strube [28...

  2. 40 CFR 59.100 - Applicability and designation of regulated entity.

    Science.gov (United States)

    2010-07-01

    ... States) for use by original equipment manufacturers. (4) Coatings that are sold in nonrefillable aerosol... distribution in the United States. (b) Regulated entities are manufacturers and importers of...

  3. Entity information life cycle for big data master data management and information integration

    CERN Document Server

    Talburt, John R

    2015-01-01

    Entity Information Life Cycle for Big Data walks you through the ins and outs of managing entity information so you can successfully achieve master data management (MDM) in the era of big data. This book explains big data's impact on MDM and the critical role of entity information management system (EIMS) in successful MDM. Expert authors Dr. John R. Talburt and Dr. Yinle Zhou provide a thorough background in the principles of managing the entity information life cycle and provide practical tips and techniques for implementing an EIMS, strategies for exploiting distributed processing to hand

  4. 76 FR 4933 - Environmental Review Procedures for Entities Assuming HUD Environmental Review Responsibilities...

    Science.gov (United States)

    2011-01-27

    ... Responsibilities; Notice of Proposed Information Collection: Comment Request AGENCY: Office of the Assistant...: Environmental Review Procedures for Entities Assuming HUD Environmental Responsibilities. OMB Control...

  5. Updates in Orbital Tumors

    Institute of Scientific and Technical Information of China (English)

    Nila; F.Moeloek

    1993-01-01

    Orbital anatomy, the clinical features of orbital tumors, the recent development of the diagnosis and management of orbital tumors were described. The incidence of orbital tumors in Dr. Cipto Mangunkusumo Hospital in the past years were introduced. The principle of management of orbital tumors and their prognosis were discussed.

  6. Pulmonary neuroendocrine tumors with nuclear inclusion.

    Science.gov (United States)

    Kobayashi, Saori; Tsuta, Koji; Sekine, Shigeki; Yoshida, Akihiko; Sasaki, Naoshi; Shibuki, Yasuo; Sakurai, Hiroyuki; Watanabe, Shun-Ichi; Asamura, Hisao; Tsuda, Hitoshi

    2013-09-01

    Nuclear inclusion or pseudoinclusion is a peculiar cytological feature, and its recognition in appropriate clinicopathological settings can aid in the diagnosis of several disease entities. To the best of our knowledge, only 1 case of pulmonary neuroendocrine tumor (NET) with nuclear pseudoinclusion has been reported. A review of 227 patients who had undergone surgical resection for pulmonary NETs revealed 2 tumors with different mechanisms of nuclear inclusion. To explore the cause of nuclear inclusion, NET with nuclear inclusion was characterized immunohistochemically and ultrastructurally. Nuclear inclusions were observed in 2 of the 227 (0.9%) patients with pulmonary NETs. The first patient was a 46-year-old woman with small cell carcinoma. Tumor cells with nuclear inclusions were distributed focally. Ultrastructural analysis showed that these inclusions were pseudoinclusions. The second patient was a 62-year-old man with large-cell neuroendocrine carcinoma. Nuclear inclusions were observed in the focal area of the tumor. Immunohistochemical analysis revealed that the intra-nuclear materials consisted of biotin and aberrant cytoplasmic and nuclear accumulation of β-catenin. Mutational analysis revealed a CTNNB1 gene mutation. Although very rare, diagnostic errors may be observed in cases of pulmonary NETs with nuclear inclusions. The mechanisms of nuclear inclusion differed, with one due to herniation of the cytoplasm into the nucleus (pseudoinclusion) and the other due to accumulation of biotin resulting from a CTNNB1 gene mutation. PMID:23896262

  7. Usual Tumor at an Unusual Site - A Leiomyoma Masquerading as a Urethral Polyp.

    Directory of Open Access Journals (Sweden)

    Shilpa MN

    2013-01-01

    Full Text Available Polyps and papillomas encompass the most common benign tumors of the urethra.Leiomyoma of urethra is a rare clinical entity which can be diagnosed only with histopathological examination and only around 35 such cases have been reported worldwide.

  8. Supratentorial tumors; Supratentorielle Tumoren

    Energy Technology Data Exchange (ETDEWEB)

    Grunwald, I.; Dillmann, K.; Roth, C.; Backens, M.; Reith, W. [Universitaetsklinikum Saarland, Homburg (Germany). Klinik fuer Diagnostische und Interventionelle Neuroradiologie

    2007-06-15

    Magnetic resonance imaging is a routine diagnostic measure for a suspected intracerebral mass. Computed tomography is usually also indicated. Further diagnostic procedures as well as the interpretation of the findings vary depending on the tumor location. This contribution discusses the symptoms and diagnostics for supratentorial tumors separated in relation to their intra- or extracranial location. Supratentorial tumors include astrocytoma, differentiated by their circumscribed and diffuse growth, ganglioglioma, ependyoma, neurocytoma, primitive neuroectodermal tumors (PNET), oligodendroglioma, dysembryoplastic neuroepithelial tumors (DNET), meningoangiomatosis, pineal tumors, hamartoma, lymphoma, craniopharyngeoma and metastases. The supratentorial extracranial tumors include the choroid plexus, colloid cysts, meningeoma, infantile myofibromatosis and lipoma. The most common subforms, especially of astrocytoma, will also be presented. (orig.)

  9. Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor.

    Directory of Open Access Journals (Sweden)

    Neil L Spector

    Full Text Available The paradigm shift in cancer treatment from cytotoxic drugs to tumor targeted therapies poses new challenges, including optimization of dose and schedule based on a biologically effective dose, rather than the historical maximum tolerated dose. Optimal dosing is currently determined using concentrations of tyrosine kinase inhibitors in plasma as a surrogate for tumor concentrations. To examine this plasma-tumor relationship, we explored the association between lapatinib levels in tumor and plasma in mice and humans, and those effects on phosphorylation of human epidermal growth factor receptors (HER in human tumors.Mice bearing BT474 HER2+ human breast cancer xenografts were dosed once or twice daily (BID with lapatinib. Drug concentrations were measured in blood, tumor, liver, and kidney. In a randomized phase I clinical trial, 28 treatment-naïve female patients with early stage HER2+ breast cancer received lapatinib 1000 or 1500 mg once daily (QD or 500 mg BID before evaluating steady-state lapatinib levels in plasma and tumor.In mice, lapatinib levels were 4-fold higher in tumor than blood with a 4-fold longer half-life. Tumor concentrations exceeded the in vitro IC90 (~ 900 nM or 500 ng/mL for inhibition of HER2 phosphorylation throughout the 12-hour dosing interval. In patients, tumor levels were 6- and 10-fold higher with QD and BID dosing, respectively, compared to plasma trough levels. The relationship between tumor and plasma concentration was complex, indicating multiple determinants. HER receptor phosphorylation varied depending upon lapatinib tumor concentrations, suggestive of changes in the repertoire of HER homo- and heterodimers.Plasma lapatinib concentrations underestimated tumor drug levels, suggesting that optimal dosing should be focused on the site of action to avoid to inappropriate dose escalation. Larger clinical trials are required to determine optimal dose and schedule to achieve tumor concentrations that maximally

  10. Manipulation of nano-entities in suspension by electric fields

    Science.gov (United States)

    Fan, Donglei

    Nanoscale entities, including nanospheres, nanodisks, nanorings, nanowires and nanotubes are potential building blocks for nanoscale devices. Among them, nanowires is an important type of nanoparticles, due to the potential application in microelectronics and bio-diagnosis. Manipulation of nanowires in suspension has been a formidable problem. As described in this thesis, using AC electric fields applied to strategically designed microelectrodes, nanowires in suspension can be driven to align, to chain, to accelerate in directions parallel and perpendicular to its orientation, to concentrate onto designated places, and to disperse in a controlled manner with high efficiency despite an extremely low Reynolds number at the level of 10-5. Randomly oriented nanowires in suspension can be rapidly assembled into extended nonlinear structures within seconds. We show that both the electric field and its gradient play the essential roles of aligning and transporting the nanowires into scaffolds according to the electric field distributions inherent to the geometry of the microelectrodes. The assembling efficiency depends strongly on the frequency of the applied AC voltages and varies as square of the voltage. Furthermore, nanowires have been rotated by AC electric fields applied to strategically designed electrodes. The rotation of the nanowires can be instantly switched on or off with precisely controlled rotation speed (to at least 25000 rpm), definite chirality, and total angle of rotation. This new method has been used to controllably rotate magnetic and non-magnetic nanowires as well as multi-wall carbon nanotubes. We have also produced a micromotor using a rotating nanowire that can drive particles into circular motion. This has application to microfluidic devices, micro-stirrers, and micro electromechanical systems (MEMS). To move and place nanowires onto designated locations with high precision, electrophoretic force has been combined with dielectrophoretic force to

  11. DOING BUSINESS IN ROMANIA - PART I: PERSPECTIVES ON THE TYPES OF DOING BUSINESS. TYPES OF INDIVIDUAL AND COMPANY ENTITIES WITHOUT LEGAL PERSONALITY. TYPES OF ENTITIES WITH LEGAL PERSONALITY

    Directory of Open Access Journals (Sweden)

    Rodica Diana APAN

    2014-12-01

    Full Text Available The analysis in the present study integrates the types of trading entities in order to clearly determine them. A first reference theme when setting-up a business is that of the legal personality it would take. The new Civil Code, acting as common law in the field of trading entities, determines the realignment and balancing of the regulations on types of business. Company Law 31 of 1990 preserves the types of trading entities with legal personality regulated here: general partnership, limited partnership, limited partnership by shares, limited liability company, joint-stock company. The simple partnership which can gain legal personality is widely regulated, and for the partnership are mainly preserved the landmarks drawn by the Commercial Code of 1886 that is presently repealed. In conclusion, the present study analyses and answers the question – who are the legal trading entities and what are the regulated types of business.

  12. CHALLENGES IN BRONCHIAL CHALLENGE TESTING

    NARCIS (Netherlands)

    Lexmond, A. J.; Hagedoorn, P.; Frijlink, H. W.; de Boer, A. H.

    2013-01-01

    Background: In the adenosine 5'-monophosphate (AMP) bronchial challenge test, AMP is usually administered according to dosing protocols developed for histamine/methacholine. It has never been thoroughly investigated whether these protocols are suitable for AMP as well. Methods: The setup of the two-

  13. Imaging the Tumor Microenvironment

    OpenAIRE

    LeBleu, Valerie

    2015-01-01

    The tumor microenvironment is a complex, heterogeneous, and dominant component of solid tumors. Cancer imaging strategies of a subset of characteristics of the tumor microenvironment are under active development and currently used modalities and novel approaches are summarized here. Understanding the dynamic and evolving functions of the tumor microenvironment is critical to accurately inform imaging and clinical care of cancer. Novel insights into distinct roles of the tumor microenvironment...

  14. Aggressive Angiomyxoma of the Vulva: a Distinct Clinical Entity

    Directory of Open Access Journals (Sweden)

    Sevgi Bakaris

    2015-12-01

    Full Text Available Aggressive angiomyxoma is a rare mesenchmal tumour arising from connective tissue of the perineum or the lower pelvis, and affect predominantly young women. Our case was 20-year-old female who was operated for a vulvar mass clinically misdiagnosed as Polyp . Histopathological examination of the surgical specimen revealed, haphazardly scattered spindle or stellate shaped mesenchymal cells and vessels of medium size having dilated lumens within a loose hyposellular myxoid stroma No mitoses were evident.The spindle-or stellate-shaped tumor cells were diffusely positive for vimentin, but negative for cytokeratin, S-100 protein, and myoglobin and and #945;-smooth muscle actin by immunohistochemistry. These histologic and immunohistochemical findings were compatible with diagnosis of AA. Clinically AA is mixed with Bartholin's duct cyst, vulvar abscess, lipoma, vaginal cysts in diagnosis AA of the vulva must be distinguished from the more common benign and malignant myxoid tumors including myxoma, myxoid neurofibroma, pseudosarcoma, myxoid liposarcoma, myxoid leiomyosarcoma and other soft tissue tumors with secondary myxoid changes. [Cukurova Med J 2015; 40(4.000: 803-806

  15. Juvenile granulosa cell tumour: a rare clinical entity

    Directory of Open Access Journals (Sweden)

    Kaliki Hymavathi Reddy

    2014-08-01

    Full Text Available Ovarian cancer is the third most common neoplasm of the female genital tract. Based on the cell type of origin, primary ovarian malignancies are classified into surface epithelium, germ cell, and sex cord tumors. Sex cord tumors account for 1% to 2% of ovarian malignancies. They may contain granulosa cells, theca cells, sertoli cells, or fibroblasts of gonadal stromal origin. Granulosa Cell Tumours (GCTs account for approximately 2-5% of all ovarian tumors and can be divided into adult (95% and juvenile (5% types based on histologic findings. GCTs secrete estrogen thus resulting in menstrual irregularities in the affected individual. More serious estrogen effects can occur in various end organs such as uterus resulting in endometrial hyperplasia, endometrial adenocarcinomas and increased risk of breast cancers. Androgen production is also reported but rare and produces virilization in the affected women. Juvenile Granulosa Cell Tumours (JGCTs are clinically and histopathologically distinct from the GCTs. They are rarely encountered but mostly in youngsters. Surgery is the primary modality of treatment with chemotherapy being reserved for advanced or recurrent disease states. We herewith report an interesting case of JGCT in a young teenage girl. [Int J Reprod Contracept Obstet Gynecol 2014; 3(4.000: 1150-1154

  16. Mobility Challenges

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Lassen, Claus

    2011-01-01

    This article takes point of departure in the challenges to understand the importance of contemporary mobility. The approach advocated is a cross-disciplinary one drawing on sociology, geography, urban planning and design, and cultural studies. As such the perspective is to be seen as a part...... of the so-called ‘mobility turn’ within social science. The perspective is illustrative for the research efforts at the Centre for Mobility and Urban Studies (C-MUS), Aalborg University. The article presents the contours of a theoretical perspective meeting the challenges to research into contemporary urban...... mobilities. In particular the article discusses 1) the physical city, its infrastructures and technological hardware/software, 2) policies and planning strategies for urban mobility and 3) the lived everyday life in the city and the region....

  17. A Case of Malignant Peripheral Nerve Sheath Tumor with Rhabdomyoblastic Differentiation: Malignant Triton Tumor

    Directory of Open Access Journals (Sweden)

    Kenichiro Mae

    2013-12-01

    Full Text Available Malignant peripheral nerve sheath tumors (MPNST constitute a rare variety of soft tissue sarcomas thought to originate from Schwann cells or pluripotent cells of the neural crest. Malignant triton tumor (MTT, a very rare, highly aggressive soft tissue tumor, is a subgroup of MPNST and is comprised of malignant Schwann cells coexisting with malignant rhabdomyoblasts. We herein report the case of a 24-year-old man who presented a subcutaneous mass in his right thigh. The mass was removed surgically in its entirety and radiation therapy was applied locally to prevent tumor regrowth. Nonetheless, the patient died 10 months after surgery from metastases to the lung and brain. He presented neither cafe-au-lait spots nor cutaneous neurofibromas. The histopathology showed a transition from a neurofibroma to an MTT, making this the second report of an MTT arising from a neurofibroma without neurofibromatosis type 1, an autosomal dominant disorder with which 50-70% of tumors reported in previous studies were associated. A histopathological examination using immunostaining with desmin confirmed this diagnosis. MTT has a poorer prognosis than MPNST and should therefore be regarded as a distinct clinical entity.

  18. Intrarenal neuroblastoma mimics Wilms' tumor; Neuroblastoma intrarenal mimetizando tumor de Wilms

    Energy Technology Data Exchange (ETDEWEB)

    Muniz, Maria T. Cartaxo; Soares, Andrezza B.; Freitas, Elizabete M. [Pernambuco Univ., Recife, PE (Brazil). Hospital Universitario Oswaldo Cruz. Inst. de Ciencias Biologicas]. E-mail: tcartaxo@icb.upe.br; Araujo, Marcela [Centro Infantil Boldrini, Campinas, SP (Brazil). Lab. de Biologia Molecular; Pureza, Leda M.M.; Morais, Adriana; Antunes, Consuelo; Salles, Terezinha de J. Marques; Borges, Josenilda C.; Morais, Vera L.L. de [Pernambuco Univ., Recife, PE (Brazil). Hospital Universitario Oswaldo Cruz; Romualdo Filho, Jose [Pernambuco Univ., Recife, PE (Brazil). Hospital Universitario Oswaldo Cruz. Centro Integrado de Anatomia Patologica; Magalhaes, Mario H. [Instituto Nacional de Cancer, Rio de Janeiro, RJ (Brazil). Dept. de Patologia

    2005-07-01

    This work reports the case history of a child with intrarenal neuroblastoma, initially diagnosed as Wilms' tumor. The patient, a one year and three months old girl, presented a hard abdominal mass on the left flank that extended to the meso gastric region, plus fever and paleness. The ultrasound of the entire abdomen revealed an intrarenal mass. Biopsy with fine needle in many points of the tumor revealed Wilms' tumor. The scarcely of the material, however, made immunohistoquemistry impossible at that moment. Because of the child's severe condition the SIOP protocol was started. As no clinical response was observed, an exploratory laparotomy was indicated with partial resection of the tumor and bone marrow aspiration (MO). The histopathologic study revealed a malignant neoplasia of small cells, poorly differentiated. IHQ was negative for WT-1 and positive for NB-84, synaptofisin, cromogranine. N-myc amplification was observed by molecular biology. The bone marrow aspiration identified metastatic small round cells infiltration. Intrarenal neuroblastoma is a rare entity that clinically and radiographically resembles Wilms' tumor. The objective of this case report is to show the importance of immunohistochemical and molecular analysis in the diagnosis of intrarenal neuroblastoma. (author)

  19. Posterior Fossa Tumor in Children

    Directory of Open Access Journals (Sweden)

    Seyed Mahmoud TABATABAEI

    2012-06-01

    Full Text Available How to Cite this Article: Tabatabaei SM, Seddighi A, Seddighi AS. Posterior Fossa Tumor in Children. Iran. J. Child. Neurol 2012;6(2: 19-24. Objective Primary brain tumors are the most common solid neoplasms of childhood, representing 20% of all pediatric tumors. The best current estimates place the incidence between 2.76 and 4.28/100,000 children per year. Compared with brain tumors in adults, a much higher percentage of pediatric brain tumors arise in the posterior fossa. Infratentorial tumors comprise as many as two thirds of all pediatric brain tumors in some large series. Tumor types that most often occur in the posterior fossa include medulloblastoma, ependymoma, cerebellar astrocytoma and brainstem glioma. Materials & Methods All pediatric cases of posterior fossa tumor that were considered for surgery from 1981 to 2011 were selected and the demographic data including age, gender and tumor characteristics along with the location and pathological diagnosis were recorded. The surgical outcomes were assessed according to pathological diagnosis. Results Our series consisted of 84 patients (52 males, 32 females. Cerebellar symptoms were the most common cause of presentation (80.9% followed by headache (73.8% and vomiting (38.1%. The most common histology was medulloblastoma (42.8% followed by cerebellar astrocytoma (28.6%, ependymoma (14.3%, brainstem glioma (7.2% and miscellaneous pathologies (e.g., dermoid,  andtuberculoma (7.2%. Conclusion The diagnosis of brain tumors in the general pediatric population remains challenging. Most symptomatic children require several visits to a physician before the correct diagnosis is made. These patients are often misdiagnosed for gastrointestinal disorders. Greater understanding of the clinical presentation of these tumors and judicious use of modern neuroimaging techniques should lead to more efficacious therapies.References 1. Mehta V, Chapman A, McNeely PD, Walling S, Howes WJ. Latency between

  20. Tumor Lysis Syndrome in Primitive Neuroectodermal Tumor

    Directory of Open Access Journals (Sweden)

    Animesh Das

    2016-07-01

    Full Text Available Tumor lysis syndrome (TLS consists of a triad of hyperuricemia, hyperphosphatemia, and hyperkalemia along with secondary hypocalcemia. It results from the massive release of intracellular ions from chemosensitive tumor cell death. Hematological malignancies such as acute leukemia and non- Hodgkin lymphoma are considered high risk for developing TLS. Solid tumors are considered less likely to develop TLS. We herein report a case of primitive neuroectodermal tumor developing TLS within 24 h of starting chemotherapy. The child developed severe clinical TLS and could not be saved. We think solid tumors with large tumor load needs to be classified as high risk for development of TLS. Prophylactic use of hyperhydration and other medical measures to prevent TLS is warranted in such cases.

  1. Post-traumatic cervical spondyloptosis: A rare entity with multiple management options.

    Science.gov (United States)

    Padwal, A; Shukla, D; Bhat, D I; Somanna, S; Devi, B I

    2016-06-01

    Post-traumatic cervical spondyloptosis is a rare condition associated with high energy injuries, and to our knowledge only case reports are available. There are no universally accepted treatment paradigms for these cases and management is individualised according to the case and surgeon preference. We retrospectively analysed our management and clinical outcomes of this condition. From January 2007 to August 2014 we treated eight patients with cervical spondyloptosis at our institute. Only two patients had no neurological deficits; all the remaining patients had partial cord injury. Seven were treated surgically with preoperative traction followed by anterior cervical discectomy and fusion with fixation in three patients, and combined anterior and posterior fusion and fixation in four. Depending on the presence of anterior compression by a disc an anterior first or posterior first approach was advocated. All four combined anterior and posterior fusion and fixation patients needed to be turned more than once (540°). There was no neurological deterioration in any of the patients, as they either improved or remained stable neurologically. Post-traumatic cervical spondyloptosis is a challenging entity to manage. Surgery can be done safely with good clinical and radiological outcome and needs to be tailored to the individual patient. PMID:26922508

  2. Dengue, chikungunya … and the missing entity - Zika fever: A new emerging threat.

    Science.gov (United States)

    Tilak, Rina; Ray, Sougat; Tilak, V W; Mukherji, Sandip

    2016-04-01

    Zika virus (ZIKV), a relative newcomer from the flavivirus group that includes dengue, Japanese encepahalitis and yellow fever, is one of the emerging pathogens that is fast transcending geographical boundaries. It is a vector-borne disease transmitted by the same Aedes aegypti and Aedes albopictus, which cause dengue and chikungunya. In addition to the vector-mediated transmission of Zika fever, probable human-to-human transmission through exchange of body fluids, including sexual and perinatal transmission and through blood transfusion, makes containment of this new entity more challenging. Moreover, a high index of suspicion by an astute physician is necessary for diagnosis of Zika fever in view of the similarity of symptoms with dengue and chikungunya, especially in areas, where these two diseases are already endemic. Zika, till recently, has had minimal impact, but its true potential is unfolding with increasing detection of congenital malformities, Guillain-Barré syndrome and other neurological and autoimmune syndromes in patients with recent history of ZIKV infection, or when mothers get infected with Zika during first or second trimester of pregnancy. The association, however, needs to be established, nonetheless it is important that we keep a close vigil on this emerging vector borne disease - the 'ZIKA' fever. PMID:27257326

  3. Relationship between risk and transparency in the financial statements of professional services entities

    Directory of Open Access Journals (Sweden)

    Mirela Elena Nichita

    2016-05-01

    Full Text Available The purpose of financial reports is to provide useful information to users; the utility of information is defined through the qualitative characteristics (fundamental and enhancing. The financial crisis emphasized the limits of financial reporting, which has been unable to prevent investors about the risks they were facing. Due to the current changes in business environment, managers been highly motivated to rethink and improve the risk governance philosophy, processes and methodologies. The lack of quality, timely data and adequate systems to capture, report and measure the right information across the organization are fundamental challenges to implementing and sustaining all aspects of effective risk management. Starting from ‘80s, the investors have become more interested in narratives (from the Notes to financial statements, than in primary reports (which disclose financial position and performance. In this research, we aim to identify whether the accounting services entities disclose risk information in their financial statements. The research will use a regression model for the assessment of the relationship between the size, profitability, leverage ratios and risk reporting by the accounting and taxation services providers in Romania during the period 2009-2013

  4. FEATURES OF DEFINITION OF TAX BURDEN OF AN ECONOMIC ENTITY

    Directory of Open Access Journals (Sweden)

    Sobchenko N. V.

    2015-12-01

    Full Text Available The results of an analytical assessment of the developed frame of reference on concepts of tax planning, tax burden, tax burden of the enterprise are presented in article. Tax planning is the most important part of financial planning of the organization. A basis of this process is possibility of each taxpayer to use legislatively resolved means, receptions and ways directed on minimization of tax payments. Minimization of taxes is directed not only on absolute decrease in volumes of tax payments, but also on purposeful transfer of business to more favorable conditions of managing. Tax planning is connected with recognition of the right of each taxpayer to apply all legislatively resolved means, receptions and ways to decrease in tax payments. The analysis of a condition of tax burden of an economic entity of real sector of economy is carried out. It is noted, that by means of various techniques of its assessment it is possible to receive contradictory data on dynamics of change of level of tax burden. As one of factors of increasing the efficiency of business activity is optimization of tax payments and implementation of tax planning acts. Importance of realization of tax planning and optimization of tax payments is defined by desire of taxpayers to lower tax burden and explainable aspiration of the state to prevent it

  5. MOBILE ENTITIES IN WIRELESS SENSOR NETWORKS: THEORY AND PERFORMANCE ANALYSIS

    Directory of Open Access Journals (Sweden)

    Regis W. Anne

    2013-03-01

    Full Text Available Wireless Sensor Network (WSN is a collection of intelligent sensors that can communicate to form a self-organizing network and can function without human intervention for a long amount of time. Traditionally, WSN was static, but due to the necessity of today’s applications, there has been a paradigm shift from a static WSN to dynamic WSN. This dynamism can be realized by adding mobility to static WSN. Mobility can be added by introducing extra elements called Mobile Entities (MEs like Mobile Sinks (MSs, Mobile Cluster Heads (MCHs, Mobile Relays (MRs and Mobile Sensor Nodes (MSNs. Adding MEs to WSN has attracted much research interests because it can significantly improve the capability and functionality of the WSN by making it flexible to failures, ease data collection, increase energy efficiency, enhance connectivity, improve coverage and prolong network lifetime, so the full potential of MEs can be harnessed to yield maximum benefits in static WSN. The goal of this paper is to present a comparative study and performance analysis of few of the possible MEs in literature and based on the results and analysis the best ME can be chosen for the desired application.

  6. NAMED ENTITY RECOGNITION FROM BIOMEDICAL TEXT -AN INFORMATION EXTRACTION TASK

    Directory of Open Access Journals (Sweden)

    N. Kanya

    2016-07-01

    Full Text Available Biomedical Text Mining targets the Extraction of significant information from biomedical archives. Bio TM encompasses Information Retrieval (IR and Information Extraction (IE. The Information Retrieval will retrieve the relevant Biomedical Literature documents from the various Repositories like PubMed, MedLine etc., based on a search query. The IR Process ends up with the generation of corpus with the relevant document retrieved from the Publication databases based on the query. The IE task includes the process of Preprocessing of the document, Named Entity Recognition (NER from the documents and Relationship Extraction. This process includes Natural Language Processing, Data Mining techniques and machine Language algorithm. The preprocessing task includes tokenization, stop word Removal, shallow parsing, and Parts-Of-Speech tagging. NER phase involves recognition of well-defined objects such as genes, proteins or cell-lines etc. This process leads to the next phase that is extraction of relationships (IE. The work was based on machine learning algorithm Conditional Random Field (CRF.

  7. Headache associated with airplane travel: A rare entity

    Directory of Open Access Journals (Sweden)

    Ajith Cherian

    2013-01-01

    Full Text Available Airplane travel headache is rare and has recently been described as a new form of headache associated with a specific situation. Of the 1,208 patients with primary headaches attending a tertiary care neurology hospital, two (0.16% patients satisfied the criteria for headache related to airplane travel. Both the patients fulfilled the proposed diagnostic criteria for airplane travel headache. This unique headache had a mean duration of 24 minutes, localized to the medial supraorbital region described as having an intense jabbing or stabbing character that occurred exclusively and maximally during aircraft landing or take-off, following which pain intensity subsided . This rare headache felt on aircraft descent is probably due to the squeeze effect on the frontal sinus wall, when air trapped inside it contracts producing a negative pressure leading to mucosal edema, transudation and intense pain. Use of nasal decongestants either alone or in combination with naproxen sodium prior to ascent and descent abated the headache episodes. Awareness about this unique entity is essential to provide proper treatment and avoid patient suffering.

  8. Future directions for new medical entities in osteoporosis.

    Science.gov (United States)

    Ferrari, Serge

    2014-12-01

    Odanacatib, a selective cathepsin K inhibitor, decreases bone resorption, whereas osteoclast number increases and bone formation is maintained, perhaps even increased on some cortical surfaces. In a phase 2 clinical trial, post-menopausal women receiving odanacatib presented a sustained reduction of bone resorption markers, whereas procollagen type 1 N-terminal propeptide returned to normal. In turn areal bone mineral density increased continuously at both spine and hip for up to 5 years. Blosozumab and romosozumab are sclerostin neutralizing antibodies that exert potent anabolic effects on both trabecular and cortical compartments. A phase 2 clinical trial has reported areal bone mineral density gains at spine and hip that were greater with romosozumab compared with placebo, but also with teriparatide. It also showed that antagonizing sclerostin results in a transient stimulation of bone formation but progressive inhibition of bone resorption. Other new medical entities that are promising for the treatment of osteoporosis include abaloparatide, a parathyroid hormone-related analogue with improved bone formation-resorption ratio. PMID:25432357

  9. Gastric siderosis: An under-recognized and rare clinical entity

    Directory of Open Access Journals (Sweden)

    Jiten P Kothadia

    2016-02-01

    Full Text Available The increased deposition of iron in gastric mucosa is known as gastric siderosis. It is believed that the only regulated step of the iron metabolism cycle occurs during absorption in the small intestine. Once this system becomes overwhelmed due to either local or widespread iron levels, then iron can be absorbed very quickly by a passive concentration-dependent mechanism. This excess iron is initially stored in the liver but later can be found in the pancreas, heart and joints. Excess iron is not expected to deposit in the gastric mucosa. This gastric deposition has been found in association with hemochromatosis, oral iron medications, alcohol abuse, blood transfusions, hepatic cirrhosis and spontaneous portacaval shunt with esophageal varices. The precise mechanism of this iron deposition in gastric epithelial and stromal cells is still not well understood; thus, identification of iron in gastric mucosa raises many questions. On histology, the pattern of deposition is variable, and recognition of the pattern is often useful to choose the appropriate workup for the patient and to diagnose and possibly treat the cause of iron overload. In this article, we have described a well-referenced review of this rare clinical entity with different histological patterns, diagnostic tests and the clinical significance of the different patterns of iron deposition.

  10. Challenges for Healthcare in the 21st Century: How Family Medicine Can Help

    OpenAIRE

    Beswal, Gaurav

    2013-01-01

    Career in medicine is challenging. Medical education system is a ever evolving entity. Due to certain bottle necks in the medical education system, young medical graduates in India are facing difficulties in career progression. Author draws from the experience of Britain and explores how family medicine could be answer to many question which the Indian health system is challenged with.

  11. Cancer Stem Cells, Tumor Dormancy, And Metastasis

    Directory of Open Access Journals (Sweden)

    Purvi ePatel

    2012-10-01

    Full Text Available Tumor cells can persist undetectably for an extended period of time in primary tumors and in disseminated cancer cells. Very little is known about why and how these tumors persist for extended periods of time and then evolve to malignancy. The discovery of cancer stem cells (CSCs in human tumors challenges our current understanding of tumor recurrence, drug resistance, and metastasis, and opens up new research directions on how cancer cells are capable of switching from dormancy to malignancy. Although overlapping molecules and pathways have been reported to regulate the stem-like phenotype of CSCs and metastasis, accumulated evidence has suggested additional clonal diversity within the stem-like cancer cell subpopulation. This review will describe the current hypothesis linking CSCs and metastasis and summarize mechanisms important for metastatic CSCs to re-initiate tumors in the secondary sites. A better understanding of CSCs’ contribution to clinical tumor dormancy and metastasis will provide new therapeutic revenues to eradicate metastatic tumors and significantly reduce the mortality of cancer patients.

  12. Brenner or non-Brenner′s?: A diagnostic challenge!!

    Directory of Open Access Journals (Sweden)

    Samarth Shukla

    2012-01-01

    Full Text Available Ovarian tumors are broadly classified into surface epithelial, germ cell, sex cord, and stromal tumors and other rarer special categories under the WHO scheme. The Brenner tumors of the surface epithelial group pose a diagnostic challenge in special context of its histogenesis. We present a case of 46-year-old female with an ovarian mass and ascitis. The surgico-pathological evaluation of gross and microscopic features suggested a malignant Brenner tumor. Transitional cell carcinoma (non-Brenner was kept as a diagnostic differential and a challenging pitfall.

  13. 22 CFR 709.4 - Cause for suspension of entities from eligibility.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Cause for suspension of entities from eligibility. 709.4 Section 709.4 Foreign Relations OVERSEAS PRIVATE INVESTMENT CORPORATION ADMINISTRATIVE PROVISIONS FOREIGN CORRUPT PRACTICES ACT OF 1977 § 709.4 Cause for suspension of entities from...

  14. 15 CFR 744.10 - Restrictions on certain entities in Russia.

    Science.gov (United States)

    2010-01-01

    ... Russia. 744.10 Section 744.10 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign... REGULATIONS CONTROL POLICY: END-USER AND END-USE BASED § 744.10 Restrictions on certain entities in Russia. (a) General prohibition. Certain entities in Russia are included in Supplement No. 4 to this part 744...

  15. 75 FR 11223 - Lifting of Nonproliferation Measures Against One Russian Entity

    Science.gov (United States)

    2010-03-10

    ... FR 42089). Dated: March 4, 2010. Vann H. Van Diepen, Acting Assistant Secretary of State for... of Nonproliferation Measures Against One Russian Entity AGENCY: Department of State. ACTION: Notice..., 1994, as amended, to remove nonproliferation measures on one Russian entity. DATES: Effective...

  16. 75 FR 5836 - Lifting of Nonproliferation Measures Against One Russian Entity

    Science.gov (United States)

    2010-02-04

    ... July 30, 1998 (see 63 FR 42089). Dated: January 29, 2010. C.S. Eliot Kang, Acting Assistant Secretary... of Nonproliferation Measures Against One Russian Entity AGENCY: Department of State. ACTION: Notice..., 1994, as amended, to remove nonproliferation measures on one Russian entity. DATES: Effective...

  17. 78 FR 38782 - Lifting of Chemical and Biological Weapons (CBW) Proliferation Sanctions Against Chinese Entities

    Science.gov (United States)

    2013-06-27

    ... These restrictions were imposed on July 9, 2002 (see Volume 67 FR Public Notice 4071). Dated: June 21... of Chemical and Biological Weapons (CBW) Proliferation Sanctions Against Chinese Entities AGENCY... lift nonproliferation measures on Chinese entities. DATES: Effective Date: Upon publication in...

  18. 15 CFR 744.20 - License requirements that apply to certain sanctioned entities.

    Science.gov (United States)

    2010-01-01

    ... unless specifically authorized on the Entity List. (c) Licensing policy. Applications to export, reexport... Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT... certain sanctioned entities. BIS may impose, as foreign policy controls, export, reexport, and...

  19. 26 CFR 301.7701-3 - Classification of certain business entities.

    Science.gov (United States)

    2010-04-01

    ... this section are filed to classify S1, S2, and S3 each as disregarded as an entity separate from its... association (S1), which wholly owns another eligible entity classified as an association (S2), which wholly... into Parent, then S2 is treated as liquidating into Parent, and finally S3 is treated as...

  20. 31 CFR 30.2 - Q-2: To what entities does this part apply?

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Q-2: To what entities does this part apply? 30.2 Section 30.2 Money and Finance: Treasury Office of the Secretary of the Treasury TARP STANDARDS FOR COMPENSATION AND CORPORATE GOVERNANCE § 30.2 Q-2: To what entities does this part apply?...

  1. 78 FR 78910 - Comparability Determination for Japan: Certain Entity-Level Requirements

    Science.gov (United States)

    2013-12-27

    ... COMMISSION Comparability Determination for Japan: Certain Entity-Level Requirements AGENCY: Commodity Futures... substituted compliance determination.\\3\\ \\2\\ 78 FR 43785 (July 22, 2013). \\3\\ The Entity-Level Requirements... of Japan. SUMMARY: The following is the analysis and determination of the Commodity Futures...

  2. SOME FEATURES OF THE RELATIONSHIP OF CIVIL LIABILITY OF PUBLIC ENTITIES

    OpenAIRE

    Kamyshanskiy V. P.; Carnushin V. E.

    2014-01-01

    The article deals with the civil liability of public entities as a kind of civil legal relationships. We have analyzed the features of this relationship in comparison with a common understanding of civil liability legal relationship, which is not complicated with public-law entity

  3. 77 FR 43429 - Unblocking of 1 Individual and 2 Entities Designated Pursuant to Executive Order 13315

    Science.gov (United States)

    2012-07-24

    ... Persons (``SDN List''). DATES: The removal of these individual and entities from the SDN List is effective... these 1 individual and 2 entities should be removed from the SDN List. The following designations are removed from the SDN List: Individual 1. KARAM, Nabil Victor, c/o ALFA COMPANY LIMITED FOR...

  4. 18 CFR 39.10 - Changes to an Electric Reliability Organization Rule or Regional Entity Rule.

    Science.gov (United States)

    2010-04-01

    ... with the Commission for approval any proposed Electric Reliability Organization Rule or Rule change. A Regional Entity shall submit a Regional Entity Rule or Rule change to the Electric Reliability Organization... or upon complaint, may propose a change to an Electric Reliability Organization Rule or...

  5. 7 CFR 372.6 - Early planning for applicants and non-APHIS entities.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Early planning for applicants and non-APHIS entities... IMPLEMENTING PROCEDURES § 372.6 Early planning for applicants and non-APHIS entities. Each prospective... environmental documentation is encouraged to contact, at the earliest opportunity, APHIS' program staff....

  6. 32 CFR 174.11 - Leasing of real property to non-Federal entities.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Leasing of real property to non-Federal entities... Property § 174.11 Leasing of real property to non-Federal entities. (a) Leasing of real property to non... leasing property at fair market value, to assist local redevelopment efforts the Secretary concerned...

  7. 40 CFR 59.201 - Applicability and designation of regulated entity.

    Science.gov (United States)

    2010-07-01

    ...-aerosol moth proofing products that are principally for the protection of fabric from damage by moths and... regulated entity is: the manufacturer or importer of the product; and any distributor that is named on the product label. The manufacturer or importer of the product is a regulated entity for purposes...

  8. Taxation as an instrument of stimulation of innovation-active business entities

    OpenAIRE

    Andrey Nechaev

    2014-01-01

    The analysis of the theoretical material revealed the lack of consensus on defini-tion of the tax stimulation of innovation-active business entities within the re-gional taxation. The definition tax stimulation of innovation-active business en-tities is specified.

  9. Accessing Data Bases Through Interface Views Using a Unified Graph-Oriented Entity-Relationship Model

    DEFF Research Database (Denmark)

    Kraft, Peter; Sørensen, Jens Otto

    with a unified graphic model is more efficient and less error-prone than working with more complex ER models and models based on lexical description. Key terms: Entity-relationship model, path expressions, entity-relationship language, derived interface view, view updates, graphical models....

  10. 45 CFR 150.305 - Determination of entity liable for civil money penalty.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Determination of entity liable for civil money... With Respect to Issuers and Non-Federal Governmental Plans-Civil Money Penalties § 150.305 Determination of entity liable for civil money penalty. If a failure to comply is established under this...

  11. Entity Relation Detection with Factorial Hidden Markov Models and Maximum Entropy Discriminant Latent Dirichlet Allocations

    Science.gov (United States)

    Li, Dingcheng

    2011-01-01

    Coreference resolution (CR) and entity relation detection (ERD) aim at finding predefined relations between pairs of entities in text. CR focuses on resolving identity relations while ERD focuses on detecting non-identity relations. Both CR and ERD are important as they can potentially improve other natural language processing (NLP) related tasks…

  12. Surgery of malignant pancreatic tumors

    International Nuclear Information System (INIS)

    Ductal adenocarcinoma is the most common malignant tumor of the pancreas. Despite great efforts in basic and clinical pancreatic cancer research, the prognosis remains poor with an overall 5-year survival rate of less than 5%. Complete surgical resection represents the only curative treatment option and 5-year survival rates of 20-25% can be achieved following curative resection and adjuvant chemotherapy. Although pancreatic surgery is considered one of the most technically demanding and challenging procedures, there has been constant progress in surgical techniques and advances in perioperative care with a modern interdisciplinary approach including anesthesiology, oncology, radiology and nursing. This has reduced morbidity and especially mortality rates in high-volume centers. Among extended resection procedures multivisceral and venous resections are technically feasible and should be considered if a complete tumor resection can be achieved. Multimodal regimens have shown promising results, however, only adjuvant chemotherapy is supported by solid evidence from randomized controlled trials. (orig.)

  13. Endoscopic resection of subepithelial tumors

    Institute of Scientific and Technical Information of China (English)

    Arthur; Schmidt; Markus; Bauder; Bettina; Riecken; Karel; Caca

    2014-01-01

    Management of subepithelial tumors(SETs) remains challenging. Endoscopic ultrasound(EUS) has improved differential diagnosis of these tumors but a definitive diagnosis on EUS findings alone can be achieved in the minority of cases. Complete endoscopic resection may provide a reasonable approach for tissue acquisition and may also be therapeutic in case of malignant lesions. Small SET restricted to the submucosa can be removed with established basic resection techniques. However, resection of SET arising from deeper layers of the gastrointestinal wall requires advanced endoscopic methods and harbours the risk of perforation. Innovative techniques such as submucosal tunneling and full thickness resection have expanded the frontiers of endoscopic therapy in the past years. This review will give an overview about endoscopic resection techniques of SET with a focus on novel methods.

  14. On the use of Dynamic Topologies for Representing Spatially Moving Entities

    Directory of Open Access Journals (Sweden)

    Barros Fernando

    2013-01-01

    Full Text Available In many psychical systems, entities can only communicate when within the range of their sensors. When entities are static, the topology of the communication infrastructure can be known in advance and kept unchanged during simulation. However, representing moving entities becomes more complex since interconnections change with time as the relative distances between entities evolve. Given the dynamic nature of the problem, a common solution involves the use of publish/subscribe communication and the corresponding multicast message passing. In this paper we exploit the use of a peer-to-peer infrastructure (p2p exhibiting a dynamic topology as an alternative representation for spatially moving entities. We use the Heterogeneous Flow Systems Specification (HFSS, a modular modeling formalism designed to represent hybrid systems with time-variant topologies. We present a simplified model of a defense system comprising airborne radars, drone detection and cancellation. We demonstrate the benefits of p2p communication over publish subscribe interaction.

  15. Combining Local Scoring and Global Aggregation to Rank Entities for Deep Web Queries

    Institute of Scientific and Technical Information of China (English)

    Yue Kou; De-Rong Shen; Ge Yu; Tie-Zheng Nie

    2009-01-01

    With the rapid growth of Web databases, it is necessary to extract and integrate large-scale data available in Deep Web automatically. But current Web search engines conduct page-level ranking, which are becoming inadequate for entity-oriented vertical search. In this paper, we present an entity-level ranking mechanism called LG-ERM for Deep Web queries based on local scoring and global aggregation. Unlike traditional approaches, LG-ERM considers more rank influencing factors including the uncertainty of entity extraction, the style information of the entities and the importance of the Web sources, as well as the entity relationship. By combining local scoring and global aggregation in ranking, the query result can be more accurate and effective to meet users' needs. The experiments demonstrate the feasibility and effectiveness of the key techniques of LG-ERM.

  16. Infratentorial angioleiomyoma: a new location for a rare neoplastic entity.

    Science.gov (United States)

    Gasco, Jaime; Franklin, Brodus; Rangel-Castilla, Leonardo; Campbell, Gerald A; Eltorky, Mahmoud; Salinas, Paul

    2009-04-01

    Angioleiomyomas are benign neoplasms most often located in the subcutaneous tissue of middle-aged individuals and usually confined to the subcuticular and deep dermal layers of the lower extremities. An intracranial site for this tumor is exceedingly rare, with very few reports documenting locations in the neuraxis. To the authors' knowledge the present case represents the first reported instance of an infratentorial angioleiomyoma. The authors conducted a review of selected English-language papers published since 1960 describing well-documented cases of intracranial vascular leiomyomas, with detailed information on the clinical presentation, radiology, pathology, and particulars of surgical management in each case.

  17. Prevention of Tumor Formation by Latent Gammaherpesvirus Infection

    OpenAIRE

    S Raffegerst; Steer, B.; Hohloch, M.; Adler, H.

    2015-01-01

    Recent reports suggested that chronic herpesvirus infection, as a constituent of the so-called virome, may not only exert harmful effects but may also be beneficial to the host, for example mediating increased resistance to secondary infections or to tumors. To further challenge this concept, specifically regarding increased resistance to tumors, we infected chimeric HLA-DR4-H2-E (DR4) mice, a mouse strain which spontaneously develops hematological tumors, with the rodent herpesvirus murine g...

  18. Data Challenges

    CERN Multimedia

    McCubbin, N A

    Some two years ago we planned a series of Data Challenges starting at the end of 2001. At the time, that seemed to be comfortingly far in the future... Well, as the saying goes, doesn't time fly when you are having fun! ATLAS Computing is now deep in the throes of getting the first Data Challenge (DC0) up and running. One of the main aims of DC0 is to have a software 'release' in which we can generate full physics events, track all particles through the detector, simulate the detector response, reconstruct the event, and study it, with appropriate data storage en route. As all software is "always 95% ready" (!), we have been able to do most of this, more or less, for some time. But DC0 forces us to have everything working, together, at the same time: a reality check. DC0 should finish early next year, and it will be followed almost immediately afterwards by DC1 (DC0 was foreseen as the 'check' for DC1). DC1 will last into the middle of 2002, and has two major goals. The first is generation, simulation, and r...

  19. Bilateral Sertoli-Leydig cell tumor in a primigravida: a rare case

    Directory of Open Access Journals (Sweden)

    Ruchita Tyagi

    2014-06-01

    Full Text Available We present a unique case of incidentally discovered bilateral Sertoli Leydig cell tumor in a primigravida who displayed no features of virilization. The apha fetoprotein levels were elevated. Magnetic resonance imaging was suggestive of ovarian tumors, possibly germ cell tumor. Bilateral salpingo-oophorectomy was performed and histopathology showed features of Sertoli Leydig cell tumor with intermediate to poor differentiation. Immunohistochemistry was positive for calretinin and inhibin, while cytokeratin was negative. Four courses of bleomycin-, etoposide- and cisplatin-based chemotherapy regimen was started, but the patient aborted while receiving the second cycle of chemotherapy. She received the remaining two cycles of chemotherapy and is now on close follow up with monitoring of serum inhibin levels to detect any tumor recurrence. Bilateral Sertloli Leydig cell tumor has not been reported previously in a pregnant female. The aim of this article is to describe the clinical, radiological and pathological features and management of this rare entity.

  20. Solitary Fibrous Tumor of the Kidney Developing Local Recurrence

    Directory of Open Access Journals (Sweden)

    Wataru Usuba

    2016-01-01

    Full Text Available Solitary fibrous tumor (SFT of the kidney is a rare entity and usually displays a favorable prognosis. We herein report a second case of renal SFT developing local recurrence. A 50-year-old man was referred to our hospital because of a left renal mass. An abdominal CT detected a large renal tumor and radical nephrectomy was performed with a possible diagnosis of renal cell carcinoma. The resected tumor size was measured at 17 × 11 × 8 cm. Grossly, necrosis was observed in central lesion of the tumor but hemorrhage was not observed. Microscopically, the tumor consisted of spindle-shaped cells with scant cytoplasm accompanied by hyalinized collagenous tissue, which displayed hemangiopericytomatous patterns. The cellularity was normal and nuclear pleomorphism was not observed. Ki-67 labeling index was less than 3%. The pathological diagnosis of SFT was made without obvious malignant findings. Three years after the surgery, a follow-up CT scan detected a mass lesion in the tumor bed. Surgical resection was performed and the resected tumor was compatible with local recurrence of the SFT without obvious malignant findings. Renal SFT should be carefully monitored even in the absence of obvious malignant findings.