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Sample records for cgmp-dependent kinase converts

  1. Similar expression patterns of bestrophin-4 and cGMP dependent Ca2+-activated chloride channel activity in the vasculature

    DEFF Research Database (Denmark)

    Bouzinova, Elena V.; Larsen, Per; Matchkov, Vladimir;

    2008-01-01

    (abstract by Matchkov et. al) that siRNA mediated downregulation of bestrophin-4 is associated with the disappearance of a recently demonstrated2 cGMP-dependent Ca2+-activated Cl- current in vascular smooth muscle cells (SMCs). Here we study the distribution of bestrophin-4-and cGMP dependent Cl- channel...... expressed epitope) Western blot detected a ~65 kDa band in cell lysates from rat mesenteric small arteries and aorta, which was not seen in pulmonary arteries and when preincubated with the immunizing peptide. The distribution of bestrophin-4 mRNA and protein has a pattern similar to the cGMP-dependent Cl......- current in SMCs of different origins. Immunohistochemistry identified bestrophin-4 both in endothelial and SMCs of the vascular tree in the brain, heart, kidney and mesentery, but not in the lungs. We suggest that bestrophin-4 is important for the cGMP dependent, Ca2+ activated Cl- conductance in many...

  2. Protein Kinase C Regulates the Cell Surface Activity of Endothelin-Converting Enzyme-1

    OpenAIRE

    Smith, A Ian; Lew, Rebecca A.; Thomas, Walter G; Tochon-Danguy, Nathalie

    2006-01-01

    The potent vasoconstrictor endothelin is a 21 amino acid peptide whose principal physiological function is to regulate vascular tone. The generation of endothelin is crucially dependent on the local presence and activity of endothelin converting enzyme-1 (ECE-1) expressed on the surface of vascular endothelial cells. In this study, we have shown in endothelial cells that the enzyme is phosphorylated, and that phosphorylation is increased by phorbol ester stimulation of protein kinase C (PKC)....

  3. Protein Kinase C Regulates the Cell Surface Activity of Endothelin-Converting Enzyme-1.

    Science.gov (United States)

    Smith, A Ian; Lew, Rebecca A; Thomas, Walter G; Tochon-Danguy, Nathalie

    2006-09-01

    The potent vasoconstrictor endothelin is a 21 amino acid peptide whose principal physiological function is to regulate vascular tone. The generation of endothelin is crucially dependent on the local presence and activity of endothelin converting enzyme-1 (ECE-1) expressed on the surface of vascular endothelial cells. In this study, we have shown in endothelial cells that the enzyme is phosphorylated, and that phosphorylation is increased by phorbol ester stimulation of protein kinase C (PKC). Furthermore, by monitoring specific ECE-1 activity on the surface of live cells, we also show that following PKC activation, enzyme activity is significantly increased at the cell surface, where it is positioned to catalyse the generation of active endothelin. We believe this novel finding is unprecedented for a peptide processing enzyme. Indeed, this new knowledge regarding the control of endothelin production by regulating ECE-1 activity at the cell surface opens up a new area of endothelin biology and will provide novel insights into the physiology and pathophysiology of endothelin and endothelin-associated diseases. In addition, the information generated in these studies may provide valuable new insights into potential extra- and intracellular targets for the pharmacological and perhaps even therapeutic regulation of endothelin production and thus vascular tone. PMID:19617920

  4. Mitogen-activated protein kinase kinase 1/2 inhibition and angiotensin II converting inhibition in mice with cardiomyopathy caused by lamin A/C gene mutation

    International Nuclear Information System (INIS)

    Highlights: • Both ACE and MEK1/2 inhibition are beneficial on cardiac function in Lmna cardiomyopathy. • MEK1/2 inhibitor has beneficial effects beyond ACE inhibition for Lmna cardiomyopathy. • These results provide further preclinical rationale for a clinical trial of a MEK1/2 inhibitor. - Abstract: Background: Mutations in the LMNA gene encoding A-type nuclear lamins can cause dilated cardiomyopathy with or without skeletal muscular dystrophy. Previous studies have shown abnormally increased extracellular signal-regulated kinase 1/2 activity in hearts of LmnaH222P/H222P mice, a small animal model. Inhibition of this abnormal signaling activity with a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor has beneficial effects on heart function and survival in these mice. However, such treatment has not been examined relative to any standard of care intervention for dilated cardiomyopathy or heart failure. We therefore examined the effects of an angiotensin II converting enzyme (ACE) inhibitor on left ventricular function in LmnaH222P/H222P mice and assessed if adding a MEK1/2 inhibitor would provide added benefit. Methods: Male LmnaH222P/H222P mice were treated with the ACE inhibitor benazepril, the MEK1/2 inhibitor selumetinib or both. Transthoracic echocardiography was used to measure left ventricular diameters and fractional shortening was calculated. Results: Treatment of LmnaH222P/H222P mice with either benazepril or selumetinib started at 8 weeks of age, before the onset of detectable left ventricular dysfunction, lead to statistically significantly increased fractional shortening compared to placebo at 16 weeks of age. There was a trend towards a great value for fractional shortening in the selumetinib-treated mice. When treatment was started at 16 weeks of age, after the onset of left ventricular dysfunction, the addition of selumetinib treatment to benazepril lead to a statistically significant increase in left ventricular fractional

  5. Mitogen-activated protein kinase kinase 1/2 inhibition and angiotensin II converting inhibition in mice with cardiomyopathy caused by lamin A/C gene mutation

    Energy Technology Data Exchange (ETDEWEB)

    Muchir, Antoine, E-mail: a.muchir@institut-myologie.org [Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY (United States); Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY (United States); Wu, Wei [Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY (United States); Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY (United States); Sera, Fusako; Homma, Shunichi [Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY (United States); Worman, Howard J., E-mail: hjw14@columbia.edu [Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY (United States); Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY (United States)

    2014-10-03

    Highlights: • Both ACE and MEK1/2 inhibition are beneficial on cardiac function in Lmna cardiomyopathy. • MEK1/2 inhibitor has beneficial effects beyond ACE inhibition for Lmna cardiomyopathy. • These results provide further preclinical rationale for a clinical trial of a MEK1/2 inhibitor. - Abstract: Background: Mutations in the LMNA gene encoding A-type nuclear lamins can cause dilated cardiomyopathy with or without skeletal muscular dystrophy. Previous studies have shown abnormally increased extracellular signal-regulated kinase 1/2 activity in hearts of Lmna{sup H222P/H222P} mice, a small animal model. Inhibition of this abnormal signaling activity with a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor has beneficial effects on heart function and survival in these mice. However, such treatment has not been examined relative to any standard of care intervention for dilated cardiomyopathy or heart failure. We therefore examined the effects of an angiotensin II converting enzyme (ACE) inhibitor on left ventricular function in Lmna{sup H222P/H222P} mice and assessed if adding a MEK1/2 inhibitor would provide added benefit. Methods: Male Lmna{sup H222P/H222P} mice were treated with the ACE inhibitor benazepril, the MEK1/2 inhibitor selumetinib or both. Transthoracic echocardiography was used to measure left ventricular diameters and fractional shortening was calculated. Results: Treatment of Lmna{sup H222P/H222P} mice with either benazepril or selumetinib started at 8 weeks of age, before the onset of detectable left ventricular dysfunction, lead to statistically significantly increased fractional shortening compared to placebo at 16 weeks of age. There was a trend towards a great value for fractional shortening in the selumetinib-treated mice. When treatment was started at 16 weeks of age, after the onset of left ventricular dysfunction, the addition of selumetinib treatment to benazepril lead to a statistically significant increase in left

  6. Expression of Extracellular Signal-regulated Kinase and Angiotensin-converting Enzyme in Human Atria during Atrial Fibrillation

    Institute of Scientific and Technical Information of China (English)

    戴友平; 王祥; 曹林生; 杨杪; 邬堂春

    2004-01-01

    Summary: In order to investigate the changes in the expression of extracellular signal-regulated kinase (ERK1/ERK2) and angiotensin-converting enzyme (ACE) in the patients with atrial fibrillation (AF), 52 patients with rheumatic heart diseases were examined. Nineteen patients had chronic persistent AF (AF≥6 months, CAF), 12 patients had paroxymal AF (PAF) and 21 patients had no history of AF. The ERK expression was detected at the mRNA level by reverse transcription polymerase chain reaction, at the protein level by Western blotting and at atrial tissue level by immunohistochemistry. ERK-activating kinases (MEK1/2) and ACE were determined by Western blotting techniques. The expression of ERK2-mRNA was increased in the patients with CAF (74±19 U vs sinus rhythm: 32±24 U, P<0.05). Activated ERK1/ERK2 and MEK1/2 were increased to more than 150 % in the patients with AF compared to those with sinus rhythm. No significant difference between CAF and PAF was found. The expression of ACE was three-fold increased in the patients with CAF compared to those with sinus rhythm. Patients with AF showed an increased expression of ERK1/ERK2 in atrial interstitial cells and marked atrial fibrosis. An ACE-dependent increase in the amounts of activated ERK1/ERK2 in atrial interstitial cells may be one of molecular mechanisms for the development of atrial fibrosis in the patients with AF. These findings may have important impact on the treatment of AF.

  7. Phosphorylation of the mRNA cap binding protein and eIF-4A by different protein kinases

    International Nuclear Information System (INIS)

    These studies were done to determine the identity of a protein kinase that phosphorylates the mRNA cap binding protein (CBP). Two chromatographic steps (dye and ligand and ion exchange HPLC) produced a 500x purification of an enzyme activity in rabbit reticulocytes that phosphorylated CBP at serine residues. Isoelectric focusing analysis of kinase treated CBP demonstrated 5 isoelectric species of which the 2 most anodic species were phosphorylated (contained 32P). This kinase activity phosphorylated CBP when it was isolated or in the eIF-4F complex. Purified protein kinase C, cAMP or cGMP dependent protein kinase, casein kinase I or II, myosin light chain kinase or insulin receptor kinase did not significantly phosphorylate isolated CBP or CBP in the eIF-4F complex. However, cAMP and cGMP dependent protein kinases and casein kinase II phosphorylated eIF-4A but did not phosphorylate the 46 kDa component of eIF-4F. cAMP dependent protein kinase phosphorylated a ∼ 220 kDa protein doublet in eIF-4F preparations. These studies indicate that CBP kinase activity probably represents a previously unidentified protein kinase. In addition, eIF-4A appears to be phosphorylated by several protein kinases whereas the 46 kDa component of the eIF-4F complex was not

  8. Converting potent indeno[1,2-b]indole inhibitors of protein kinase CK2 into selective inhibitors of the breast cancer resistance protein ABCG2.

    Science.gov (United States)

    Jabor Gozzi, Gustavo; Bouaziz, Zouhair; Winter, Evelyn; Daflon-Yunes, Nathalia; Aichele, Dagmar; Nacereddine, Abdelhamid; Marminon, Christelle; Valdameri, Glaucio; Zeinyeh, Waël; Bollacke, Andre; Guillon, Jean; Lacoudre, Aline; Pinaud, Noël; Cadena, Silvia M; Jose, Joachim; Le Borgne, Marc; Di Pietro, Attilio

    2015-01-01

    A series of indeno[1,2-b]indole-9,10-dione derivatives were synthesized as human casein kinase II (CK2) inhibitors. The most potent inhibitors contained a N(5)-isopropyl substituent on the C-ring. The same series of compounds was found to also inhibit the breast cancer resistance protein ABCG2 but with totally different structure-activity relationships: a N(5)-phenethyl substituent was critical, and additional hydrophobic substituents at position 7 or 8 of the D-ring or a methoxy at phenethyl position ortho or meta also contributed to inhibition. The best ABCG2 inhibitors, such as 4c, 4h, 4i, 4j, and 4k, behaved as very weak inhibitors of CK2, whereas the most potent CK2 inhibitors, such as 4a, 4p, and 4e, displayed limited interaction with ABCG2. It was therefore possible to convert, through suitable substitutions of the indeno[1,2-b]indole-9,10-dione scaffold, potent CK2 inhibitors into selective ABCG2 inhibitors and vice versa. In addition, some of the best ABCG2 inhibitors, which displayed a very low cytotoxicity, thus giving a high therapeutic ratio, and appeared not to be transported, constitute promising candidates for further investigations.

  9. PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.

    Science.gov (United States)

    Dong, Lily Q; Liu, Feng

    2005-08-01

    Activation of members of the protein kinase AGC (cAMP dependent, cGMP dependent, and protein kinase C) family is regulated primarily by phosphorylation at two sites: a conserved threonine residue in the activation loop and a serine/threonine residue in a hydrophobic motif (HM) near the COOH terminus. Although phosphorylation of these kinases in the activation loop has been found to be mediated by phosphoinositide-dependent protein kinase-1 (PDK1), the kinase(s) that catalyzes AGC kinase phosphorylation in the HM remains uncharacterized. So far, at least 10 kinases have been suggested to function as an HM kinase or the so-called "PDK2," including mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2), integrin-linked kinase (ILK), p38 MAP kinase, protein kinase Calpha (PKCalpha), PKCbeta, the NIMA-related kinase-6 (NEK6), the mammalian target of rapamycin (mTOR), the double-stranded DNA-dependent protein kinase (DNK-PK), and the ataxia telangiectasia mutated (ATM) gene product. However, whether any or all of these kinases act as a physiological HM kinase remains to be established. Nonetheless, available data suggest that multiple systems may be used in cells to regulate the activation of the AGC family kinases. It is possible that, unlike activation loop phosphorylation, phosphorylation of the HM site in the different AGC family kinases is mediated by distinct kinases. In addition, phosphorylation of the AGC family kinase at the HM site could be cell type, signaling pathway, and substrate specific. Identification and characterization of the bonafide HM kinase(s) will be essential to verify these hypotheses. PMID:16014356

  10. A multisubstrate deoxyribonucleoside kinase from plants

    DEFF Research Database (Denmark)

    Clausen, Anders R.; Girandon, Lenart; Knecht, Wolfgang;

    2008-01-01

    Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship...... in anti-cancer therapy....

  11. Wavelength Converters

    DEFF Research Database (Denmark)

    Kloch, Allan; Hansen, Peter Bukhave; Wolfson, David;

    1999-01-01

    at 2.5 Gbit/s, the regeneration causes a reduction of the required input power to an in-line EDFA of ~6 dB for a power penalty of 1 dB at a bit error rate of 10-9. If two converters are concatenated the power requirement is reduced ~8 dB. Obviously, the power reduction allows for longer spans between....... It is predicted that jitter accumulation can be minimised by using a 9-10 dB ratio between the signal and CW power also assuring a high extinction ratio. Using this guideline simulations show that 20 cross-gain modulation converters can be cascaded at 10 Gbit/s with only ~20 ps of accumulated jitter...... and an extinction ratio of ~10 dB.The regenerative capabilities of the cross-phase converters are described and verified experimentally at 20 Gbit/s, where the noise redistribution and improvement of the signal-to-noise ratio clearly is demonstrated by controlling the input power to an EDFA. In a similar experiment...

  12. Diacylglycerol Kinase Inhibition and Vascular Function

    OpenAIRE

    Choi, Hyehun; Allahdadi, Kyan J.; Tostes, Rita C A; Webb, R. Clinton

    2009-01-01

    Diacylglycerol kinases (DGKs), a family of lipid kinases, convert diacylglycerol (DG) to phosphatidic acid (PA). Acting as a second messenger, DG activates protein kinase C (PKC). PA, a signaling lipid, regulates diverse functions involved in physiological responses. Since DGK modulates two lipid second messengers, DG and PA, regulation of DGK could induce related cellular responses. Currently, there are 10 mammalian isoforms of DGK that are categorized into five groups based on their structu...

  13. Casein kinases

    DEFF Research Database (Denmark)

    Issinger, O G

    1993-01-01

    , no genetic changes are necessarily involved; the observed changes may be entirely due to a signal transduction pathway where CK-2 could be phosphorylated by another kinase(s). CK-2 cDNAs from various organisms have been isolated and characterized. From the deduced amino acid sequence it turns out that CK-2......-specific expression of CK-2 at the mRNA and at the protein level has also been given attention. The fact that the enzyme activity is surprisingly high in brain and low in heart and lung may be indicative of involvement of CK-2 in processes other than proliferation.(ABSTRACT TRUNCATED AT 400 WORDS)...

  14. Wavelength converter technology

    DEFF Research Database (Denmark)

    Kloch, Allan; Hansen, Peter Bukhave; Poulsen, Henrik Nørskov;

    1999-01-01

    Wavelength conversion is important since it ensures full flexibility of the WDM network layer. Progress in optical wavelength converter technology is reviewed with emphasis on air-optical wavelength converter types based on semiconductor optical amplifiers....

  15. Wavelength converter technology

    DEFF Research Database (Denmark)

    Kloch, Allan; Hansen, Peter Bukhave; Poulsen, Henrik Nørskov;

    1999-01-01

    Wavelength conversion is important since it ensures full flexibility of the WDM network layer. Progress in optical wavelength converter technology is reviewed with emphasis on all-optical wavelength converter types based on semiconductor optical amplifiers.......Wavelength conversion is important since it ensures full flexibility of the WDM network layer. Progress in optical wavelength converter technology is reviewed with emphasis on all-optical wavelength converter types based on semiconductor optical amplifiers....

  16. Immunochemical characterization of rat brain protein kinase

    International Nuclear Information System (INIS)

    Polyclonal antibodies against rat brain protein kinase C (the Ca2+/phospholipid-dependent enzyme) were raised in goat. These antibodies can neutralize completely the kinase activity in purified enzyme preparation as well as that in the crude homogenate. Immunoblot analysis of the purified and the crude protein kinase C preparations revealed a major immunoreactive band of 80 kDa. The antibodies also recognize the same enzyme from other rat tissues. Neuronal tissues (cerebral cortex, cerebellum, hypothalamus, and retina) and lymphoid organs (thymus and spleen) were found to be enriched in protein kinase C, whereas lung, kidney, liver, heart, and skeletal muscle contained relatively low amounts of this kinase. Limited proteolysis of the purified rat brain protein kinase C with trypsin results in an initial degradation of the kinase into two major fragments of 48 and 38 kDa. Both fragments are recognized by the antibodies. However, further digestion of the 48-kDa fragment to 45 kDa and the 38-kDa fragment to 33 kDa causes a loss of the immunoreactivity. Upon incubation of the cerebellar extract with Ca2+, the 48-kDa fragment was also identified as a major proteolytic product of protein kinase C. Proteolytic degradation of protein kinase C converts the Ca2+/phospholipid-dependent kinase to an independent form without causing a large impairment of the binding of [3H]phorbol 12,13-dibutyrate. The two major proteolytic fragments were separated by ion exchange chromatography and one of them (45-48 kDa) was identified as a protein kinase and the other (33-38 kDa) as a phorbol ester-binding protein. These results demonstrate that rat brain protein kinase C is composed of two functionally distinct units, namely, a protein kinase and a Ca2+-independent/phospholipid-dependent phorbol ester-binding protein

  17. Protein Kinase D family kinases

    OpenAIRE

    Wille, Christoph; Seufferlein, Thomas; Eiseler, Tim

    2014-01-01

    Highly invasive pancreatic tumors are often recognized in late stages due to a lack of clear symptoms and pose major challenges for treatment and disease management. Broad-band Protein Kinase D (PKD) inhibitors have recently been proposed as additional treatment option for this disease. PKDs are implicated in the control of cancer cell motility, angiogenesis, proliferation and metastasis. In particular, PKD2 expression is elevated in pancreatic cancer, whereas PKD1 expression is comparably lo...

  18. Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase

    Institute of Scientific and Technical Information of China (English)

    Sergiy; Kostenko; Gianina; Dumitriu; Kari; Jenssen; Lgreid; Ugo; Moens

    2011-01-01

    Mitogen-activated protein kinases(MAPKs)are a family of proteins that constitute signaling pathways involved in processes that control gene expression,cell division, cell survival,apoptosis,metabolism,differentiation and motility.The MAPK pathways can be divided into conventional and atypical MAPK pathways.The first group converts a signal into a cellular response through a relay of three consecutive phosphorylation events exerted by MAPK kinase kinases,MAPK kinase,and MAPK.Atypical MAPK pathways are not organized into this three-tiered cascade.MAPK that belongs to both conventional and atypical MAPK pathways can phosphorylate both non-protein kinase substrates and other protein kinases.The latter are referred to as MAPK-activated protein kinases.This review focuses on one such MAPK-activated protein kinase,MAPK-activated protein kinase 5(MK5)or p38-regulated/activated protein kinase(PRAK).This protein is highly conserved throughout the animal kingdom and seems to be the target of both conventional and atypical MAPK pathways.Recent findings on the regulation of the activity and subcellular localization,bona fide interaction partners and physiological roles of MK5/PRAK are discussed.

  19. Digital to Analog Converter

    NARCIS (Netherlands)

    Westra, Jan R.; Annema, Anne J.; Boom, van den Jeroen M.; Dijkmans, Eise C.

    2002-01-01

    A digital to analog converter (DAC) for converting a digital signal (DS) having a maximum voltage range which corresponds to a first supply voltage (UL) into an analog signal (UOUT) having a maximum voltage range which corresponds to a second supply voltage (UH). The first supply voltage (UL) is off

  20. Digital to Analog Converter

    NARCIS (Netherlands)

    Westra, Jan R.; Annema, Anne J.; Boom, van den Jeroen M.; Dijkmans, Eise C.

    2006-01-01

    A digital to analog converter (DAC) for converting a digital signal (DS) having a maximum voltage range which corresponds to a first supply voltage (UL) into an analog signal (UOUT) having a maximum voltage range which corresponds to a second supply voltage (UH). The first supply voltage (UL) is off

  1. Cascaded resonant bridge converters

    Science.gov (United States)

    Stuart, Thomas A. (Inventor)

    1989-01-01

    A converter for converting a low voltage direct current power source to a higher voltage, high frequency alternating current output for use in an electrical system where it is desired to use low weight cables and other circuit elements. The converter has a first stage series resonant (Schwarz) converter which converts the direct current power source to an alternating current by means of switching elements that are operated by a variable frequency voltage regulator, a transformer to step up the voltage of the alternating current, and a rectifier bridge to convert the alternating current to a direct current first stage output. The converter further has a second stage series resonant (Schwarz) converter which is connected in series to the first stage converter to receive its direct current output and convert it to a second stage high frequency alternating current output by means of switching elements that are operated by a fixed frequency oscillator. The voltage of the second stage output is controlled at a relatively constant value by controlling the first stage output voltage, which is accomplished by controlling the frequency of the first stage variable frequency voltage controller in response to second stage voltage. Fault tolerance in the event of a load short circuit is provided by making the operation of the first stage variable frequency voltage controller responsive to first and second stage current limiting devices. The second stage output is connected to a rectifier bridge whose output is connected to the input of the second stage to provide good regulation of output voltage wave form at low system loads.

  2. SSG Wave Energy Converter

    DEFF Research Database (Denmark)

    Margheritini, Lucia; Vicinanza, Diego; Frigaard, Peter

    2008-01-01

    The SSG (Sea Slot-cone Generator) is a wave energy converter of the overtopping type. The structure consists of a number of reservoirs one on the top of each others above the mean water level, in which the water of incoming waves is stored temporary. In each reservoir, expressively designed low...... head hydroturbines are converting the potential energy of the stored water into power. A key to success for the SSG will be the low cost of the structure and its robustness. The construction of the pilot plant is scheduled and this paper aims to describe the concept of the SSG wave energy converter...

  3. Converting Nonclassicality into Entanglement.

    Science.gov (United States)

    Killoran, N; Steinhoff, F E S; Plenio, M B

    2016-02-26

    Quantum mechanics exhibits a wide range of nonclassical features, of which entanglement in multipartite systems takes a central place. In several specific settings, it is well known that nonclassicality (e.g., squeezing, spin squeezing, coherence) can be converted into entanglement. In this work, we present a general framework, based on superposition, for structurally connecting and converting nonclassicality to entanglement. In addition to capturing the previously known results, this framework also allows us to uncover new entanglement convertibility theorems in two broad scenarios, one which is discrete and one which is continuous. In the discrete setting, the classical states can be any finite linearly independent set. For the continuous setting, the pertinent classical states are "symmetric coherent states," connected with symmetric representations of the group SU(K). These results generalize and link convertibility properties from the resource theory of coherence, spin coherent states, and optical coherent states, while also revealing important connections between local and nonlocal pictures of nonclassicality. PMID:26967398

  4. Converting Nonclassicality into Entanglement.

    Science.gov (United States)

    Killoran, N; Steinhoff, F E S; Plenio, M B

    2016-02-26

    Quantum mechanics exhibits a wide range of nonclassical features, of which entanglement in multipartite systems takes a central place. In several specific settings, it is well known that nonclassicality (e.g., squeezing, spin squeezing, coherence) can be converted into entanglement. In this work, we present a general framework, based on superposition, for structurally connecting and converting nonclassicality to entanglement. In addition to capturing the previously known results, this framework also allows us to uncover new entanglement convertibility theorems in two broad scenarios, one which is discrete and one which is continuous. In the discrete setting, the classical states can be any finite linearly independent set. For the continuous setting, the pertinent classical states are "symmetric coherent states," connected with symmetric representations of the group SU(K). These results generalize and link convertibility properties from the resource theory of coherence, spin coherent states, and optical coherent states, while also revealing important connections between local and nonlocal pictures of nonclassicality.

  5. Thermionic photovoltaic energy converter

    Science.gov (United States)

    Chubb, D. L. (Inventor)

    1985-01-01

    A thermionic photovoltaic energy conversion device comprises a thermionic diode mounted within a hollow tubular photovoltaic converter. The thermionic diode maintains a cesium discharge for producing excited atoms that emit line radiation in the wavelength region of 850 nm to 890 nm. The photovoltaic converter is a silicon or gallium arsenide photovoltaic cell having bandgap energies in this same wavelength region for optimum cell efficiency.

  6. Improving Power Converter Reliability

    DEFF Research Database (Denmark)

    Ghimire, Pramod; de Vega, Angel Ruiz; Beczkowski, Szymon;

    2014-01-01

    The real-time junction temperature monitoring of a high-power insulated-gate bipolar transistor (IGBT) module is important to increase the overall reliability of power converters for industrial applications. This article proposes a new method to measure the on-state collector?emitter voltage...... of a high-power IGBT module during converter operation, which may play a vital role in improving the reliability of the power converters. The measured voltage is used to estimate the module average junction temperature of the high and low-voltage side of a half-bridge IGBT separately in every fundamental...... cycle of the current by calibrating them at load current. The measurement is very accurate and also measures the voltage at the middle of a pulse-width modulation (PWM) switching. A major objective is that this method is designed to be implemented in real applications. The performance of this technique...

  7. Angiotensin-converting enzyme

    DEFF Research Database (Denmark)

    Sørensen, P G; Rømer, F K; Cortes, D

    1984-01-01

    In order to evaluate bleomycin-associated lung damage in humans, lung function parameters and serum levels of the endothelial-bound angiotensin-converting enzyme (ACE) were determined by serial measurements in 11 patients who were treated for testicular cancer. None developed clinical or radiolog......In order to evaluate bleomycin-associated lung damage in humans, lung function parameters and serum levels of the endothelial-bound angiotensin-converting enzyme (ACE) were determined by serial measurements in 11 patients who were treated for testicular cancer. None developed clinical...

  8. The Convertible Arbitrage Strategy Analyzed

    NARCIS (Netherlands)

    Loncarski, I.; Ter Horst, J.R.; Veld, C.H.

    2006-01-01

    This paper analyzes convertible bond arbitrage on the Canadian market for the period 1998 to 2004.Convertible bond arbitrage is the combination of a long position in convertible bonds and a short position in the underlying stocks. Convertible arbitrage has been one of the most successful strategies

  9. Convertible Proxy Signcryption Scheme

    Institute of Scientific and Technical Information of China (English)

    李继国; 李建中; 曹珍富; 张亦辰

    2004-01-01

    In 1996, Mambo et al introduced the concept of proxy signature. However, proxy signature can only provide the delegated authenticity and cannot provide confidentiality. Recently, Gamage et al and Chan and Wei proposed different proxy signcryption schemes respectively, which extended the concept of proxy signature.However, only the specified receiver can decrypt and verify the validity of proxy signcryption in their schemes.To protect the receiver' s benefit in case of a later dispute, Wu and Hsu proposed a convertible authenticated encryption scheme, which carn enable the receiver to convert signature into an ordinary one that can be verified by anyone. Based on Wu and Hsu' s scheme and improved Kim' s scheme, we propose a convertible proxy signcryption scheme. The security of the proposed scheme is based on the intractability of reversing the one-way hash function and solving the discrete logarithm problem. The proposed scheme can satisfy all properties of strong proxy signature and withstand the public key substitution attack and does not use secure channel. In addition, the proposed scheme can be extended to convertible threshold proxy signcryption scheme.

  10. An Electromagnetic Beam Converter

    DEFF Research Database (Denmark)

    2009-01-01

    The present invention relates to an electromagnetic beam converter and a method for conversion of an input beam of electromagnetic radiation having a bell shaped intensity profile a(x,y) into an output beam having a prescribed target intensity profile l(x',y') based on a further development...

  11. Definition of Power Converters

    CERN Document Server

    Bordry, F

    2015-01-01

    The paper is intended to introduce power conversion principles and to define common terms in the domain. The concept s of sources and switches are defined and classified. From the basic laws of source interconnections, a generic method of power converter synthesis is presented. Some examples illustrate this systematic method. Finally, the commutation cell and soft commuta tion are introduced and discussedd.

  12. Fractional Watt AMTEC Converter

    Science.gov (United States)

    Hunt, T. K.; Rasmussen, J. R.

    2006-01-01

    We report here the long term performance of a small, multi-tube AMTEC converter. This converter was designed to operate and produce approximately 12 watt of electrical output from a small, 4 to 6 watt radioisotope heat source for remote power applications. It was built and put on test in 1999 using electrical heaters as stand-ins for the radioisotope capsule. Since that time it has accumulated more than 5 years of run time at an input heater temperature of 700 °C, with numerous thermal cycles to ambient that were generally related to grid power failures or physical moves of the test apparatus. The power output has remained, with variations due to orientation changes and minor variations due to small temperature changes, essentially constant at 0.40 W to 0.60 W over the test period and operation is ongoing. The converter casing and mechanical structure was fabricated from 316 SS and the electrodes are sputtered titanium nitride films. Separate static tests of a multilayer insulation package suitable for use with the converter showed the capability to reach 700 °C with a thermal input of < 4 watts.

  13. Advanced DC/DC converters

    CERN Document Server

    Luo, Fang Lin

    2003-01-01

    INTRODUCTIONHistorical ReviewMultiple Quadrant ChoppersPump CircuitsDevelopment of DC/DC Conversion TechniqueCategorize Prototypes and DC/DC Converters Family TreeVOLTAGE-LIFT CONVERTERSIntroductionSeven Self-Lift ConvertersPositive Output Luo-ConvertersNegative Output Luo-ConvertersModified Positive Output Luo-Converters Double Output Luo-ConvertersPOSITIVE OUTPUT SUPER-LIFT LUO-CONVERTERS IntroductionMain SeriesAdditional SeriesEnhanced Series Re-Enhanced Series Multiple-Enhanced Series Summary of Positive Output

  14. DSP controlled power converter

    OpenAIRE

    Chan, CH; Pong, MH

    1995-01-01

    A digital controller is designed and implemented by a Digital Signal Processor (DSP) to replace the Pulse Width Modulator (PWM) and error amplifier compensation network in a two wheeler forward converter. The DSP controller is designed in three approaches: a) Discretization of analog controller - the design is based on the transfer function of the error amplifier compensation network. b) Digital PID controller design - the design is based on the general form of the pulse transfer function of ...

  15. CK (Creatine Kinase) Test

    Science.gov (United States)

    ... be limited. Home Visit Global Sites Search Help? Creatine Kinase Share this page: Was this page helpful? Also known as: CK; Total CK; Creatine Phosphokinase; CPK Formal name: Creatine Kinase Related tests: ...

  16. Convertible bond valuation focusing on Chinese convertible bond market

    OpenAIRE

    Yang, Ke

    2010-01-01

    This paper mainly discusses the methods of valuation of convertible bonds in Chinese market. Different from common convertible bonds in European market, considering the complicate features of Chinese convertible bond, this paper represents specific pricing approaches for pricing convertible bonds with different provisions along with the increment of complexity of these provisions. More specifically, this paper represents the decomposing method and binomial tree method for pricing both of Non-...

  17. Resonant power converters

    CERN Document Server

    Kazimierczuk, Marian K

    2012-01-01

    This book is devoted to resonant energy conversion in power electronics. It is a practical, systematic guide to the analysis and design of various dc-dc resonant inverters, high-frequency rectifiers, and dc-dc resonant converters that are building blocks of many of today's high-frequency energy processors. Designed to function as both a superior senior-to-graduate level textbook for electrical engineering courses and a valuable professional reference for practicing engineers, it provides students and engineers with a solid grasp of existing high-frequency technology, while acquainting them wit

  18. Cycloidal Wave Energy Converter

    Energy Technology Data Exchange (ETDEWEB)

    Stefan G. Siegel, Ph.D.

    2012-11-30

    This program allowed further advancing the development of a novel type of wave energy converter, a Cycloidal Wave Energy Converter or CycWEC. A CycWEC consists of one or more hydrofoils rotating around a central shaft, and operates fully submerged beneath the water surface. It operates under feedback control sensing the incoming waves, and converts wave power to shaft power directly without any intermediate power take off system. Previous research consisting of numerical simulations and two dimensional small 1:300 scale wave flume experiments had indicated wave cancellation efficiencies beyond 95%. The present work was centered on construction and testing of a 1:10 scale model and conducting two testing campaigns in a three dimensional wave basin. These experiments allowed for the first time for direct measurement of electrical power generated as well as the interaction of the CycWEC in a three dimensional environment. The Atargis team successfully conducted two testing campaigns at the Texas A&M Offshore Technology Research Center and was able to demonstrate electricity generation. In addition, three dimensional wave diffraction results show the ability to achieve wave focusing, thus increasing the amount of wave power that can be extracted beyond what was expected from earlier two dimensional investigations. Numerical results showed wave cancellation efficiencies for irregular waves to be on par with results for regular waves over a wide range of wave lengths. Using the results from previous simulations and experiments a full scale prototype was designed and its performance in a North Atlantic wave climate of average 30kW/m of wave crest was estimated. A full scale WEC with a blade span of 150m will deliver a design power of 5MW at an estimated levelized cost of energy (LCOE) in the range of 10-17 US cents per kWh. Based on the new results achieved in the 1:10 scale experiments these estimates appear conservative and the likely performance at full scale will

  19. SIGN LANGUAGE CONVERTER

    Directory of Open Access Journals (Sweden)

    Taner Arsan

    2015-08-01

    Full Text Available The aim of this paper is to design a convenient system that is helpful for the people who have hearing difficulties and in general who use very simple and effective method; sign language. This system can be used for converting sign language to voice and also voice to sign language. A motion capture system is used for sign language conversion and a voice recognition system for voice conversion. It captures the signs and dictates on the screen as writing. It also captures the voice and displays the sign language meaning on the screen as motioned image or video.

  20. SIGN LANGUAGE CONVERTER

    OpenAIRE

    Taner Arsan; Oğuz Ülgen

    2015-01-01

    The aim of this paper is to design a convenient system that is helpful for the people who have hearing difficulties and in general who use very simple and effective method; sign language. This system can be used for converting sign language to voice and also voice to sign language. A motion capture system is used for sign language conversion and a voice recognition system for voice conversion. It captures the signs and dictates on the screen as writing. It also captures the voice ...

  1. Unity power factor converter

    Science.gov (United States)

    Wester, Gene W. (Inventor)

    1980-01-01

    A unity power factor converter capable of effecting either inversion (dc-to-dc) or rectification (ac-to-dc), and capable of providing bilateral power control from a DC source (or load) through an AC transmission line to a DC load (or source) for power flow in either direction, is comprised of comparators for comparing the AC current i with an AC signal i.sub.ref (or its phase inversion) derived from the AC ports to generate control signals to operate a switch control circuit for high speed switching to shape the AC current waveform to a sine waveform, and synchronize it in phase and frequency with the AC voltage at the AC ports, by selectively switching the connections to a series inductor as required to increase or decrease the current i.

  2. Heated catalytic converter

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-01

    This article describes how the use of an auxiliary burner to heat the converter promptly can provide substantially decreased emission levels. While, in principle, there may well be solutions to decreasing warm-up phase hydrocarbon emissions, their production-level implementation is hindered by conflicting requirements, insufficiently mature technologies, and significant technical and financial restraints. The US, California, and the European Community are tightening emission standards for the transitional-low-, low-, and ultra-low-emission vehicles throughout the coming decade. The lead figure shows the fundamental possibilities for reducing harmful substances in exhaust emissions. While one can distinguish between measures taken within the engine (internal), and others outside it (external), it currently seems that only a combination of both will provide a suitable overall concept.

  3. Integrated power electronic converters and digital control

    CERN Document Server

    Emadi, Ali; Nie, Zhong

    2009-01-01

    Non-isolated DC-DC ConvertersBuck ConverterBoost ConverterBuck-Boost ConverterIsolated DC-DC ConvertersFlyback ConverterForward ConverterPush-Pull ConverterFull-Bridge ConverterHalf-Bridge ConverterPower Factor CorrectionConcept of PFCGeneral Classification of PFC CircuitsHigh Switching Frequency Topologies for PFCApplication of PFC in Advanced Motor DrivesIntegrated Switched-Mode Power ConvertersSwitched-Mode Power SuppliesThe Concept of Integrated ConverterDefinition of Integrated Switched-Mode Power Supplies (ISMPS)Boost-Type Integrated TopologiesGeneral Structure of Boost-Type Integrated T

  4. Advanced power electronics converters PWM converters processing AC voltages

    CERN Document Server

    dos Santos, Euzeli

    2014-01-01

    This book covers power electronics, in depth, by presenting the basic principles and application details, which can be used both as a textbook and reference book.  Introduces a new method to present power electronics converters called Power Blocks Geometry. Applicable for courses focusing on power electronics, power electronics converters, and advanced power converters. Offers a comprehensive set of simulation results to help understand the circuits presented throughout the book

  5. Thymidine kinases in archaea

    DEFF Research Database (Denmark)

    Clausen, A.R.; Matakos, A.; Sandrini, Michael;

    2006-01-01

    Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea...... that a functional deoxyribonucleoside salvage pathway is not crucial for the archaeal cell....

  6. Impedance source power electronic converters

    CERN Document Server

    Liu, Yushan; Ge, Baoming; Blaabjerg, Frede; Ellabban, Omar; Loh, Poh Chiang

    2016-01-01

    Impedance Source Power Electronic Converters brings together state of the art knowledge and cutting edge techniques in various stages of research related to the ever more popular impedance source converters/inverters. Significant research efforts are underway to develop commercially viable and technically feasible, efficient and reliable power converters for renewable energy, electric transportation and for various industrial applications. This book provides a detailed understanding of the concepts, designs, controls, and application demonstrations of the impedance source converters/inverters. Key features: Comprehensive analysis of the impedance source converter/inverter topologies, including typical topologies and derived topologies. Fully explains the design and control techniques of impedance source converters/inverters, including hardware design and control parameter design for corresponding control methods. Presents the latest power conversion solutions that aim to advance the role of pow...

  7. Nanostructure Neutron Converter Layer Development

    Science.gov (United States)

    Park, Cheol (Inventor); Sauti, Godfrey (Inventor); Kang, Jin Ho (Inventor); Lowther, Sharon E. (Inventor); Thibeault, Sheila A. (Inventor); Bryant, Robert G. (Inventor)

    2016-01-01

    Methods for making a neutron converter layer are provided. The various embodiment methods enable the formation of a single layer neutron converter material. The single layer neutron converter material formed according to the various embodiments may have a high neutron absorption cross section, tailored resistivity providing a good electric field penetration with submicron particles, and a high secondary electron emission coefficient. In an embodiment method a neutron converter layer may be formed by sequential supercritical fluid metallization of a porous nanostructure aerogel or polyimide film. In another embodiment method a neutron converter layer may be formed by simultaneous supercritical fluid metallization of a porous nanostructure aerogel or polyimide film. In a further embodiment method a neutron converter layer may be formed by in-situ metalized aerogel nanostructure development.

  8. Venturini Method Based Matrix Converter

    Directory of Open Access Journals (Sweden)

    Derick Mathew

    2015-03-01

    Full Text Available Recently, matrix converter has received considerable interest as a viable alternative to the conventional ac-dc-ac converter. This direct ac-ac converter provides some attractive characteristics such as: four quadrant operation, absence of bulky dc-link electrolyte capacitors, clean input power characteristics. Due to the absence of dc link energy storage elements any disturbance in the input voltage will be immediately reflected to the output voltages. In this paper venturini method for matrix converter has been presented. Three phase sinusoidal symmetrical voltage or current can obtained .

  9. A thermochemical energy converter

    Energy Technology Data Exchange (ETDEWEB)

    Toyeguti, K.; Indzima, T.

    1982-08-09

    Mercury is used as the active mass of the anode in the converter and 0/sub 2/ is used as the active cathode material. The reaction of Mercury + 1/2 0/sub 2/-Hg0 occurs with a discharge. With heating to 500/sup 0/C the regeneration of the Mercury, Hg0 yields Mercury + 1/2 0/sub 2/, occurs. The device for performing the thermochenical conversion of energy contains an element body, an oxygen chamber, an oxygen electrode, a chamber with an alkaline liquid electrolyte, a separator, an auxiliary separator, an electrode and a chamber with the Mercury. The thermochemical reaction occurs in the reactor to which the Hg0 is transported along a pipe which has a refrigerator and a valve. The Mercury is fed into the element from a reservoir. The Mercury reduced in the reactor and in a reaction tower is fed into it through a closed cycle. The bellows is connected with the reactor by a pipe with a refrigerator. Through it the 0/sub 2/ goes in a closed cycle to the chamber. The current forming reactions are Hg + 20H-anion yields Hg0 + H/sub 2/0 + 2e and 1/2 0/sub 2/ + H/sub 2/0 + 2e yields 20H-anion. The voltage on the outleads of the element is approximately 0.3 volts.

  10. Muscle phosphorylase kinase deficiency

    DEFF Research Database (Denmark)

    Preisler, N; Orngreen, M C; Echaniz-Laguna, A;

    2012-01-01

    To examine metabolism during exercise in 2 patients with muscle phosphorylase kinase (PHK) deficiency and to further define the phenotype of this rare glycogen storage disease (GSD).......To examine metabolism during exercise in 2 patients with muscle phosphorylase kinase (PHK) deficiency and to further define the phenotype of this rare glycogen storage disease (GSD)....

  11. Radiation tolerant power converter controls

    CERN Document Server

    Todd, B; King, Q; Uznanski, S

    2012-01-01

    The Large Hadron Collider (LHC) at the European Organisation for Nuclear Research (CERN) is the world's most powerful particle collider. The LHC has several thousand magnets, both warm and super-conducting, which are supplied with current by power converters. Each converter is controlled by a purpose-built electronic module called a Function Generator Controller (FGC). The FGC allows remote control of the power converter and forms the central part of a closed-loop control system where the power converter voltage is set, based on the converter output current and magnet-circuit characteristics. Some power converters and FGCs are located in areas which are exposed to beam-induced radiation. There are numerous radiation induced effects, some of which lead to a loss of control of the power converter, having a direct impact upon the accelerator's availability. Following the first long shut down (LS1), the LHC will be able to run with higher intensity beams and higher beam energy. This is expected to lead to signifi...

  12. PWM DC/DC Converter

    OpenAIRE

    Chen, Juan

    2008-01-01

    This report is the result of a Master Thesis work done at Seaward Electronics Inc. in Beijing, China from June to December in 2007. The main goal for this thesis is to verify and improve the performance of Honey-PWM DC-DC converter, which has been fabricated by a standard 0.6um CMOS processes. The project was started with studying of Buck converter structure. After the understanding of the converter structure, the project goes in to the analyses phase for each sub-cells, including the theory,...

  13. Time-to-digital converters

    CERN Document Server

    Henzler, Stephan

    2010-01-01

    This text covers the fundamentals of time-to-digital converters on analog and digital conversion principles. It includes a theoretical investigation into quantization, linearity, noise and variability, and it details a range of advanced TDC architectures.

  14. Laser system with wavelength converter

    DEFF Research Database (Denmark)

    2012-01-01

    The present invention relates to an apparatus comprising a diode laser (10) providing radiation in a first wavelength interval, a radiation conversion unit (12) having an input and an output, the radiation converter configured to receive the radiation in the first wavelength interval from the diode...... laser at the input, the radiation conversion unit configured to convert the radiation in the first wavelength interval to radiation in a second wavelength interval and the output configured to output the converted radiation, the second wavelength interval having one end point outside the first...... wavelength interval. Further, the invention relates to a method of optically pumping a target laser (14) in a laser system, the laser system comprising a laser source providing radiation at a first frequency, the laser source being optically connected to an input of a frequency converter, the frequency...

  15. Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition.

    Directory of Open Access Journals (Sweden)

    Amit K Gandhi

    Full Text Available Several drugs and natural compounds are known to be highly neurotoxic, triggering epileptic convulsions or seizures, and causing headaches, agitations, as well as other neuronal symptoms. The neurotoxic effects of some of these compounds, including theophylline and ginkgotoxin, have been traced to their inhibitory activity against human pyridoxal kinase (hPL kinase, resulting in deficiency of the active cofactor form of vitamin B₆, pyridoxal 5'-phosphate (PLP. Pyridoxal (PL, an inactive form of vitamin B₆ is converted to PLP by PL kinase. PLP is the B₆ vitamer required as a cofactor for over 160 enzymatic activities essential in primary and secondary metabolism. We have performed structural and kinetic studies on hPL kinase with several potential inhibitors, including ginkgotoxin and theophylline. The structural studies show ginkgotoxin and theophylline bound at the substrate site, and are involved in similar protein interactions as the natural substrate, PL. Interestingly, the phosphorylated product of ginkgotoxin is also observed bound at the active site. This work provides insights into the molecular basis of hPL kinase inhibition and may provide a working hypothesis to quickly screen or identify neurotoxic drugs as potential hPL kinase inhibitors. Such adverse effects may be prevented by administration of an appropriate form of vitamin B₆, or provide clues of how to modify these drugs to help reduce their hPL kinase inhibitory effects.

  16. PHASE CONVERTER OF COMPOSING DISPLACEMENT

    OpenAIRE

    SMIRNOV YU.S.; Lysov, A. N.; E.V. Yurasova; SAFRONOV V.V.; VSTAVSKAYA E.V.

    2016-01-01

    Minimax strategy of mechatronic converters efficiency improving relative to error decrease with velocity increase at the same time provides common dataware level rise. The analysis of usage possibilities of different type position transducers (PT) gives the advantages of resolvers. The subsequent processing of their output signals is performed by “Resolver-to-Digit” Converter (RDC) which provides displacement digital equivalent and digital or analog signals specifying its velocity and acceler...

  17. Boron nitride converted carbon fiber

    Energy Technology Data Exchange (ETDEWEB)

    Rousseas, Michael; Mickelson, William; Zettl, Alexander K.

    2016-04-05

    This disclosure provides systems, methods, and apparatus related to boron nitride converted carbon fiber. In one aspect, a method may include the operations of providing boron oxide and carbon fiber, heating the boron oxide to melt the boron oxide and heating the carbon fiber, mixing a nitrogen-containing gas with boron oxide vapor from molten boron oxide, and converting at least a portion of the carbon fiber to boron nitride.

  18. Transformerless dc-Isolated Converter

    Science.gov (United States)

    Rippel, Wally E.

    1987-01-01

    Efficient voltage converter employs capacitive instead of transformer coupling to provide dc isolation. Offers buck/boost operation, minimal filtering, and low parts count, with possible application in photovoltaic power inverters, power supplies and battery charges. In photovoltaic inverter circuit with transformerless converter, Q2, Q3, Q4, and Q5 form line-commutated inverter. Switching losses and stresses nil because switching performed when current is zero.

  19. Current status of converter steelmaking

    Energy Technology Data Exchange (ETDEWEB)

    Oghbasialasie, H.; Holappa, L.

    1995-12-31

    This literature work is mainly focusing on the mechanisms of modern converter steelmaking and related with the evaluation of converter technology applied during the last decades and further to the future. The history of steelmaking has been briefly reviewed from bloomeries and early-steelmaking processes to the progress of modern converter process. The pneumatic converter processes were developed in the 1850`s and thereafter the basis for the rapid growth of steel industries was established for the next 100 years. The world production of steel has not continuously grown but fluctuating quite much. It reached 723 Mt in 1994. The production is believed to grow the forecast for the year 2003 being approximately 800 Mt. Electric arc furnace production is estimated to reach 280 Mt by 2003, and BOFIOH will reach 520 Mt by 2003. The current status of the converter steelmaking process is briefly described both on its theoretical bases and practical technological progresses. Developments which significantly improve the process are briefly discussed. Several more recent developments such as combined oxygen blowing process, increased scrap melting, post combustion and hot metal pretreatment are discussed. The future progress will be in further development of these process characteristics as well as in eventual emerging of the continuous converter process. (author)

  20. Modeling of asymmetrical boost converters

    Directory of Open Access Journals (Sweden)

    Eliana Isabel Arango Zuluaga

    2014-03-01

    Full Text Available The asymmetrical interleaved dual boost (AIDB is a fifth-order DC/DC converter designed to interface photovoltaic (PV panels. The AIDB produces small current harmonics to the PV panels, reducing the power losses caused by the converter operation. Moreover, the AIDB provides a large voltage conversion ratio, which is required to step-up the PV voltage to the large dc-link voltage used in grid-connected inverters. To reject irradiance and load disturbances, the AIDB must be operated in a closed-loop and a dynamic model is required. Given that the AIDB converter operates in Discontinuous Conduction Mode (DCM, classical modeling approaches based on Continuous Conduction Mode (CCM are not valid. Moreover, classical DCM modeling techniques are not suitable for the AIDB converter. Therefore, this paper develops a novel mathematical model for the AIDB converter, which is suitable for control-pur-poses. The proposed model is based on the calculation of a diode current that is typically disregarded. Moreover, because the traditional correction to the second duty cycle reported in literature is not effective, a new equation is designed. The model accuracy is contrasted with circuital simulations in time and frequency domains, obtaining satisfactory results. Finally, the usefulness of the model in control applications is illustrated with an application example.

  1. Diacylglycerol Kinase Inhibition and Vascular Function.

    Science.gov (United States)

    Choi, Hyehun; Allahdadi, Kyan J; Tostes, Rita C A; Webb, R Clinton

    2009-01-01

    Diacylglycerol kinases (DGKs), a family of lipid kinases, convert diacylglycerol (DG) to phosphatidic acid (PA). Acting as a second messenger, DG activates protein kinase C (PKC). PA, a signaling lipid, regulates diverse functions involved in physiological responses. Since DGK modulates two lipid second messengers, DG and PA, regulation of DGK could induce related cellular responses. Currently, there are 10 mammalian isoforms of DGK that are categorized into five groups based on their structural features. These diverse isoforms of DGK are considered to activate distinct cellular functions according to extracellular stimuli. Each DGK isoform is thought to play various roles inside the cell, depending on its subcellular localization (nuclear, ER, Golgi complex or cytoplasm). In vascular smooth muscle, vasoconstrictors such as angiotensin II, endothelin-1 and norepinephrine stimulate contraction by increasing inositol trisphosphate (IP(3)), calcium, DG and PKC activity. Inhibition of DGK could increase DG availability and decrease PA levels, as well as alter intracellular responses, including calcium-mediated and PKC-mediated vascular contraction. The purpose of this review is to demonstrate a role of DGK in vascular function. Selective inhibition of DGK isoforms may represent a novel therapeutic approach in vascular dysfunction. PMID:21547002

  2. Increasing of Reliability of Converter

    Directory of Open Access Journals (Sweden)

    Trebuňa, F.

    2006-01-01

    Full Text Available The innovative activities in steel production invoke exploitation of new machines with the higher production capacity and productivity of labor. The paper deals with deformation and stress analysis of carrying parts of converter pedestal on the base of which the proposals and supporting measures were made that had the aim to increase reliability of the converter during steel production. This was achieved by lifespan prolongation of anchor and connecting bolts of converter pedestal, by change of stiffness of connected elements as well as by correction of nuts of bolted connections. The realization of structural changes decreased loading amplitudes and consequently the vibrations of pedestal. Solution was verified by numerical and experimental procedures of mechanics.

  3. Post combustion in converter steelmaking

    Energy Technology Data Exchange (ETDEWEB)

    Oghbasilasie, H.; Holappa, L.

    1997-12-31

    The purpose of this work is to study the fundamentals of post combustion and the effect of different process parameters on the post combustion ratio (PCR) and heat transfer efficiency (HTE) in converter steelmaking process. The PCR and HTE have been determined under normal operating conditions. Trials assessed the effect of lance height, vessel volume, foaming slag and pellet additions on PCR and HTE. Based on enthalpy considerations, post combustion of CO gas is regarded as one of the most effective means of increasing the heat supply to the BOP. The thermodynamic study of gas-metal-slag reactions gives the limiting conditions for post combustion inside the converter reactor. Different process parameters influencing both thermodynamic equilibria and kinetic conditions can greatly affect the post combustion ratio. Different features of converter processes as well smelting reduction processes utilizing post combustion have been reviewed. (orig.) SULA 2 Research Programme; 26 refs.

  4. From Phosphosites to Kinases

    DEFF Research Database (Denmark)

    Munk, Stephanie; Refsgaard, Jan C; Olsen, Jesper V;

    2016-01-01

    Kinases play a pivotal role in propagating the phosphorylation-mediated signaling networks in living cells. With the overwhelming quantities of phosphoproteomics data being generated, the number of identified phosphorylation sites (phosphosites) is ever increasing. Often, proteomics investigations...... sequence motifs, mostly based on large scale in vivo and in vitro experiments. The context of the kinase and the phosphorylated proteins in a biological system is equally important for predicting association between the enzymes and substrates, an aspect that is also being tackled with available...

  5. Phosphatidylinositol kinase from rabbit reticulocytes

    International Nuclear Information System (INIS)

    Phosphatidylinositol (PI) kinase was isolated from the postribosomal supernatant of rabbit reticulocytes. This activity was identified by the formation of a product that comigrated with phosphatidylinositol-4-phosphate (PIP) when purified PI was phosphorylated in the presence of [32P]ATP and Mg2+. Three major peaks of PI kinase activity were resolved by chromatography on DEAE-cellulose. The first peak eluted at 50-100 mM NaCl together with several serine protein kinases, casein kinase (CK) I and protease activated kinase (PAK) I and II. The PI kinase was subsequently separated from the protein kinases by chromatography on phosphocellulose. The second peak eluted at 125-160 mM NaCl and contained another lipid kinase activity that produced a product which comigrated with phosphatidic acid on thin layer chromatography. The third peak, which eluted at 165-200 mM NaCl, partly comigrated with casein kinase (CK) II and an active protein kinase(s) which phosphorylated mixed histone and histone I. CK II and the histone kinase activities were also separated by chromatography on phosphocelluslose. The different forms of PI kinase were characterized and compared with respect to substrate and salt requirements

  6. Converting accounts receivable into cash.

    Science.gov (United States)

    Folk, M D; Roest, P R

    1995-09-01

    In recent years, increasing numbers of healthcare providers have converted their accounts receivable into cash through a process called securitization. This practice has gained popularity because it provides a means to raise capital necessary to healthcare organizations. Although securitization transactions can be complex, they may provide increased financial flexibility to providers as they prepare for continuing change in the healthcare industry. PMID:10145096

  7. Kinase Inhibitors from Marine Sponges

    Directory of Open Access Journals (Sweden)

    Ana Zivanovic

    2011-10-01

    Full Text Available Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.

  8. Parametric study of laser photovoltaic energy converters

    Science.gov (United States)

    Walker, G. H.; Heinbockel, J. H.

    1987-01-01

    Photovoltaic converters are of interest for converting laser power to electrical power in a space-based laser power system. This paper describes a model for photovoltaic laser converters and the application of this model to a neodymium laser silicon photovoltaic converter system. A parametric study which defines the sensitivity of the photovoltaic parameters is described. An optimized silicon photovoltaic converter has an efficiency greater than 50 percent for 1000 W/sq cm of neodymium laser radiation.

  9. [Construction of the flavinogenic yeast Candida famata strains with high riboflavin kinase activity using gene engineering].

    Science.gov (United States)

    Ishchuk, O P; Iatsyshyn, V Iu; Dmytruk, K V; Voronovs'kyĭ, A Ia; Fedorovych, D V; Sybirnyĭ, A A

    2006-01-01

    The recombinant strains of the flavinogenic yeast Candida famata, which contain the DNA fragment consisting of the FMN1 gene (encoding the riboflavin kinase, enzyme that converts riboflavin to flavinmononucleotide) driven by the strong promoters (the regulated RIB1 or constitutive TEF1 promoter) were isolated. Riboflavin kinase activity in the isolated transformants was tested. The 6-8-fold increase of the riboflavin kinase activity was shown in the recombinant strains containing the integrated Debaryomyces hansenii FMN1 gene under the strong constitutive TEF1 promoter. The recombinant strains can be used for the following construction of flavinmononucleotide overproducers. PMID:17290783

  10. Vibration converter with magnetic levitation

    Science.gov (United States)

    Gladilin, A. V.; Pirogov, V. A.; Golyamina, I. P.; Kulaev, U. V.; Kurbatov, P. A.; Kurbatova, E. P.

    2015-05-01

    The paper presents a mathematical model, the results of computational and theoretical research, and the feasibility of creating a vibration converter with full magnetic levitation in the suspension of a high-temperature superconductor (HTSC). The axial and radial stability of the active part of the converter is provided by the interaction of the magnetic field of ring-shaped permanent magnets and a hollow cylinder made of the ceramic HTSC material. The force is created by a system of current-carrying coils whose magnetic field is polarized by permanent magnets and interacts with induced currents in the superconducting cylinder. The case of transition to the superconducting state of HTSC material in the field of the permanent magnets (FC mode) is considered. The data confirm the outlook for the proposed technical solutions.

  11. Photoelectric converters with quantum coherence

    Science.gov (United States)

    Su, Shan-He; Sun, Chang-Pu; Li, Sheng-Wen; Chen, Jin-Can

    2016-05-01

    Photon impingement is capable of liberating electrons in electronic devices and driving the electron flux from the lower chemical potential to higher chemical potential. Previous studies hinted that the thermodynamic efficiency of a nanosized photoelectric converter at maximum power is bounded by the Curzon-Ahlborn efficiency ηCA. In this study, we apply quantum effects to design a photoelectric converter based on a three-level quantum dot (QD) interacting with fermionic baths and photons. We show that, by adopting a pair of suitable degenerate states, quantum coherences induced by the couplings of QDs to sunlight and fermion baths can coexist steadily in nanoelectronic systems. Our analysis indicates that the efficiency at maximum power is no longer limited to ηCA through manipulation of carefully controlled quantum coherences.

  12. Reducing catalytic converter pressure loss

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-06-01

    This article examines why approximately 30--40% of total exhaust-system pressure loss occurs in the catalytic converter and what can be done to reduce pressure loss. High exhaust-system backpressure is of concern in the design of power trains for passenger cars and trucks because it penalizes fuel economy and limits peak power. Pressure losses occur due to fluid shear and turning during turbulent flow in the converter headers and in entry separation and developing laminar-flow boundary layers within the substrate flow passages. Some of the loss mechanisms are coupled. For example, losses in the inlet header are influenced by the presence of the flow resistance of a downstream substrate. Conversely, the flow maldistribution and pressure loss of the substrate(s) depend on the design of the inlet header.

  13. Collector for thermionic energy converter

    International Nuclear Information System (INIS)

    An improved collector is provided for a thermionic energy converter. The collector comprises a p-type layer of a semiconductor material formed on an n-type layer of a semiconductor material. The p-n junction is maintained in a forward biased condition. The electron affinity of the exposed surface of the p-type layer is effectively lowered to a low level near zero by the presence of a work function lowering activator. The dissipation of energy during collection is reduced by the passage of electrons through the p-type layer in the metastable conduction band state. A significant portion of the electron current remains at the potential of the fermi level of the n-type layer rather than dropping to the fermi level of the p-type layer. Less energy is therefore dissipated as heat and a higher net power output is delivered from a thermionic energy converter incorporating the collector

  14. Efficiency of Capacitively Loaded Converters

    DEFF Research Database (Denmark)

    Andersen, Thomas; Huang, Lina; Andersen, Michael A. E.;

    2012-01-01

    is introduced as a definition of efficiency. The calculated and measured efficiency curves for charging DEAP actuator, polypropylene film capacitor and X7R MLCC are provided and compared. The attention has to be paid for the voltage dependent capacitive load, like X7R MLCC, when evaluating the charging......This paper explores the characteristic of capacitance versus voltage for dielectric electro active polymer (DEAP) actuator, 2kV polypropylene film capacitor as well as 3kV X7R multi layer ceramic capacitor (MLCC) at the beginning. An energy efficiency for capacitively loaded converters...... efficiency of converter. Based on the capacitancevoltage curve, the correct capacitance should be chosen when calculating the stored energy; otherwise misleading optimistic efficiency can always be obtained. Actually, when DEAP actuator is not available at the early developing stage, the voltage independent...

  15. Radiated EMI from power converters

    Directory of Open Access Journals (Sweden)

    Arnautovski-Toševa Vesna

    2005-01-01

    Full Text Available With the continuous increase of switching frequency together with the ongoing trend to higher complexity and functionality, power converters as a part of electronic systems have raised more and more electromagnetic energy pollution to the local system environment. In the same time, stringent demands are imposed on the designers of new circuits that electromagnetic interference (EMI has to be suppressed at its source before it is allowed to propagate into other circuits and systems. In this paper, the authors present a full-wave numerical method for calculation and simulation of electromagnetic field radiated by power converter circuitry. The main objective is to analyze the layout geometry in order to obtain competitive PCB layout that will enable suitably attenuated level of the radiated electric field to safe level. By this it would be possible to ensure reliable operation of the sensitive electronic components in the proximity.

  16. Photoelectric converters with quantum coherence.

    Science.gov (United States)

    Su, Shan-He; Sun, Chang-Pu; Li, Sheng-Wen; Chen, Jin-Can

    2016-05-01

    Photon impingement is capable of liberating electrons in electronic devices and driving the electron flux from the lower chemical potential to higher chemical potential. Previous studies hinted that the thermodynamic efficiency of a nanosized photoelectric converter at maximum power is bounded by the Curzon-Ahlborn efficiency η_{CA}. In this study, we apply quantum effects to design a photoelectric converter based on a three-level quantum dot (QD) interacting with fermionic baths and photons. We show that, by adopting a pair of suitable degenerate states, quantum coherences induced by the couplings of QDs to sunlight and fermion baths can coexist steadily in nanoelectronic systems. Our analysis indicates that the efficiency at maximum power is no longer limited to η_{CA} through manipulation of carefully controlled quantum coherences.

  17. Development of a Compact Matrix Converter

    Directory of Open Access Journals (Sweden)

    J. Bauer

    2009-01-01

    Full Text Available This paper deals with the development of a matrix converter. Matrix converters belong to the category of direct frequency converters. A converter does not contain DC-link and the output voltage is provided by direct switching of voltage from the input phases. This is enabled by 9 bidirectional switches, which are provided by anti-serial connection of 18 IGBT transistors. The absence of a DC-link is great advantage of the matrix converter, but it also increases the requirements on the converter control. For this reason a new prototype of a matrix converter is being developed with sophisticated modern components (FPGA, Power PC equipped in the control part of the converter. The converter will be used for testing new control algorithms and commutation methods. 

  18. Tyrosine kinases in rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Kobayashi Akiko

    2011-08-01

    Full Text Available Abstract Rheumatoid arthritis (RA is an inflammatory, polyarticular joint disease. A number of cellular responses are involved in the pathogenesis of rheumatoid arthritis, including activation of inflammatory cells and cytokine expression. The cellular responses involved in each of these processes depends on the specific signaling pathways that are activated; many of which include protein tyrosine kinases. These pathways include the mitogen-activated protein kinase pathway, Janus kinases/signal transducers and activators transcription pathway, spleen tyrosine kinase signaling, and the nuclear factor κ-light-chain-enhancer of activated B cells pathway. Many drugs are in development to target tyrosine kinases for the treatment of RA. Based on the number of recently published studies, this manuscript reviews the role of tyrosine kinases in the pathogenesis of RA and the potential role of kinase inhibitors as new therapeutic strategies of RA.

  19. Biomass compounds converted to gasoline

    Energy Technology Data Exchange (ETDEWEB)

    1979-10-08

    It is claimed that corn, castor, and jojoba oils as well as Hevea latex can be converted in high yields to gasoline by passage over zeolite catalysts at 450 degrees to 500 degrees centigrade. Gasoline yields are 60% from corn oil (essentially tristearin), compared with 50% yields from methanol. Latex depolymerizes before conversion. Fat and oil molecules adopt conformations that enable them to enter zeolite interstices, resulting in high yields of C6 to C9 aromatics.

  20. Combined catalytic converter and afterburner

    Energy Technology Data Exchange (ETDEWEB)

    Ma, T.T.-H.

    1994-11-30

    This patent describes the combined use of a catalytic converter and afterburner. An afterburner chamber and a catalyst matrix are disposed in series within a casing. A combustible premixed charge is ignited in the afterburner chamber before it enters the catalyst matrix. This invention overcomes the problem encountered in previous designs of some of the premixed charge passing unreacted through the device unless a very long afterburner chamber is used. (UK)

  1. EMI Prediction of Switching Converters

    OpenAIRE

    Trinchero, Riccardo; Stievano, Igor Simone; Canavero, Flavio

    2015-01-01

    This paper addresses the simulation of the conducted electromagnetic interference produced by circuits with periodically switching elements. The proposed method allows for the computation of their steady-state responses by means of augmented linear time-invariant equivalents built from circuit inspection only, and standard tools for circuit analysis. The approach is demonstrated on a real dc-dc boost converter by comparing simulation results with real measurements

  2. Resonant Demagnetization PWM Forward Converter

    OpenAIRE

    BİLGİN, Bülent

    2003-01-01

    In this paper, a new approach to demagnetization process of a PWM forward converter (FC) is proposed. According to this approach, the demagnetization winding and diode of a conventional FC are removed, and an external capacitor is added in parallel with the secondary diode. This replacement changes the linear demagnetization process of a conventional FC into a resonant demagnetization process. The theoretical performance results of the proposed resonant demagnetization forward conve...

  3. Radiated EMI from power converters

    OpenAIRE

    Arnautovski-Toševa Vesna; Rousset Yanis; Drissi El Khamlichi Khalil; Grčev Leonid

    2005-01-01

    With the continuous increase of switching frequency together with the ongoing trend to higher complexity and functionality, power converters as a part of electronic systems have raised more and more electromagnetic energy pollution to the local system environment. In the same time, stringent demands are imposed on the designers of new circuits that electromagnetic interference (EMI) has to be suppressed at its source before it is allowed to propagate into other circuits and systems. In this p...

  4. Design and Control for the Buck-Boost Converter Combining 1-Plus-D Converter and Synchronous Rectified Buck Converters

    Directory of Open Access Journals (Sweden)

    Jeevan Naik

    2015-06-01

    Full Text Available In this paper, a design and control for the buck-boost converter, i.e., 1-plus-D converter with a positive output voltage, is presented, which combines the 1-plus-D converter and the synchronous rectified (SR buck converter. By doing so, the problem in voltage bucking of the 1-plus-D converter can be solved, thereby increasing the application capability of the 1-plus-D converter. Since such a converter operates in continuous conduction mode inherently, it possesses the nonpulsating output current, thereby not only decreasing the current stress on the output capacitor but also reducing the output voltage ripple. Above all, both the 1-plus-D converter and the SR buck converter, combined into a buck–boost converter with no right-half plane zero, use the same power switches, thereby causing the required circuit to be compact and the corresponding cost to be down. Furthermore, during the magnetization period, the input voltage of the 1-plus-D converter comes from the input voltage source, whereas during the demagnetization period, the input voltage of the 1-plus-D converter comes from the output voltage of the SR buck converter.

  5. Computerized simulation of converter process

    Energy Technology Data Exchange (ETDEWEB)

    Jalkanen, H.; Suomi, M.L.; Wallgren, M. [Helsinki Univ. of Technology, Otaniemi (Finland). Lab. of Metallurgy

    1996-12-31

    Converter process is essentially an oxidising refining process aiming in addition to (1) the primary refining action, decarburisation of high carbon iron melt, also to (2) maximal elimination of impurity elements, especially silicon, phosphorus and sulphur, (3) melting of substantial amounts of scrap using the extra heat released in oxidation reactions and (4) to exact final steel temperature control, optimal for further treatments. `Quantitative modelling of such a complex non-stationary chemical process as oxygen converting necessitates extensive formulation of chemical and thermal evolution of the process in connection with the technological properties of the reactor and the process control measures. A comprehensive converter simulation program like CONSIM-3. 1 and its preceding versions that is based on the theoretical and practical knowledge on the process can be used for (1) educating specialists and smelter personnel, (2) planning of the blowing programs, (3) developing and testing of process control systems and after some elaboration and restructuring (4) it can be integrated to static or dynamic process control systems. (orig.) SULA 2 Research Programme; 10 refs.

  6. Pyruvate Dehydrogenase Kinase 4

    OpenAIRE

    Cadoudal, Thomas; Distel, Emilie; Durant, Sylvie; Fouque, Françoise; Blouin, Jean-Marc; Collinet, Martine; Bortoli, Sylvie; Forest, Claude; Benelli, Chantal

    2008-01-01

    OBJECTIVE—Pyruvate dehydrogenase complex (PDC) serves as the metabolic switch between glucose and fatty acid utilization. PDC activity is inhibited by PDC kinase (PDK). PDC shares the same substrate, i.e., pyruvate, as glyceroneogenesis, a pathway controlling fatty acid release from white adipose tissue (WAT). Thiazolidinediones activate glyceroneogenesis. We studied the regulation by rosiglitazone of PDK2 and PDK4 isoforms and tested the hypothesis that glyceroneogenesis could be controlled ...

  7. Oncoprotein protein kinase

    Energy Technology Data Exchange (ETDEWEB)

    Karin, Michael (San Diego, CA); Hibi, Masahiko (San Diego, CA); Lin, Anning (La Jolla, CA); Davis, Roger (Princeton, MA); Derijard, Benoit (Shrewsbury, MA)

    2003-02-04

    An isolated polypeptide (JNK) characterized by having a molecular weight of 46kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

  8. Simulation Results of Double Forward Converter

    Directory of Open Access Journals (Sweden)

    P. Vijaya KUMAR

    2009-12-01

    Full Text Available This work aims to find a better forward converter for DC to DC conversion.Simulation of double forward converter in SMPS system is discussed in this paper. Aforward converter with RCD snubber to synchronous rectifier and/or to current doubleris also discussed. The evolution of the forward converter is first reviewed in a tutorialfashion. Performance parameters are discussed including operating principle, voltageconversion ratio, efficiency, device stress, small-signal dynamics, noise and EMI. Itscircuit operation and its performance characteristics of the forward converter with RCDsnubber and double forward converter are described and the simulation results arepresented.

  9. Cyclin-dependent kinases.

    Science.gov (United States)

    Malumbres, Marcos

    2014-01-01

    Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues. The evolutionary expansion of the CDK family in mammals led to the division of CDKs into three cell-cycle-related subfamilies (Cdk1, Cdk4 and Cdk5) and five transcriptional subfamilies (Cdk7, Cdk8, Cdk9, Cdk11 and Cdk20). Unlike the prototypical Cdc28 kinase of budding yeast, most of these CDKs bind one or a few cyclins, consistent with functional specialization during evolution. This review summarizes how, although CDKs are traditionally separated into cell-cycle or transcriptional CDKs, these activities are frequently combined in many family members. Not surprisingly, deregulation of this family of proteins is a hallmark of several diseases, including cancer, and drug-targeted inhibition of specific members has generated very encouraging results in clinical trials. PMID:25180339

  10. Structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae

    Energy Technology Data Exchange (ETDEWEB)

    Michalska, Karolina [Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory (United States); Cuff, Marianne E. [Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory (United States); Structural Biology Center, Biosciences Division, Argonne National Laboratory (United States); Tesar, Christine; Feldmann, Brian [Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory (United States); Joachimiak, Andrzej, E-mail: andrzejj@anl.gov [Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory (United States); Structural Biology Center, Biosciences Division, Argonne National Laboratory (United States); Department of Biochemistry and Molecular Biology, University of Chicago (United States)

    2011-08-01

    The crystal structure of 2-oxo-3-deoxygalactonate kinase from the De Ley–Doudoroff pathway of galactose metabolism has been determined at 2.1 Å resolution. In most organisms, efficient d-galactose utilization requires the highly conserved Leloir pathway that converts d-galactose to d-glucose 1-phosphate. However, in some bacterial and fungal species alternative routes of d-galactose assimilation have been identified. In the so-called De Ley–Doudoroff pathway, d-galactose is metabolized into pyruvate and d-glyceraldehyde 3-phosphate in five consecutive reactions carried out by specific enzymes. The penultimate step in this pathway involves the phosphorylation of 2-oxo-3-deoxygalactonate to 2-oxo-3-deoxygalactonate 6-phosphate catalyzed by 2-oxo-3-deoxygalactonate kinase, with ATP serving as a phosphoryl-group donor. Here, a crystal structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae determined at 2.1 Å resolution is reported, the first structure of an enzyme from the De Ley–Doudoroff pathway. Structural comparison indicates that the enzyme belongs to the ASKHA (acetate and sugar kinases/hsc70/actin) family of phosphotransferases. The protein is composed of two α/β domains, each of which contains a core common to all family members. Additional elements introduced between conserved structural motifs define the unique features of 2-oxo-3-deoxygalactonate kinase and possibly determine the biological function of the protein.

  11. Regulation of Autophagy by Kinases

    Energy Technology Data Exchange (ETDEWEB)

    Sridharan, Savitha; Jain, Kirti; Basu, Alakananda, E-mail: alakananda.basu@unthsc.edu [Department of Molecular Biology and Immunology, Institute for Cancer Research, University of North Texas Health Science Center, Fort Worth, TX 76107 (United States)

    2011-06-09

    Autophagy is a process of self-degradation that maintains cellular viability during periods of metabolic stress. Although autophagy is considered a survival mechanism when faced with cellular stress, extensive autophagy can also lead to cell death. Aberrations in autophagy are associated with several diseases, including cancer. Therapeutic exploitation of this process requires a clear understanding of its regulation. Although the core molecular components involved in the execution of autophagy are well studied there is limited information on how cellular signaling pathways, particularly kinases, regulate this complex process. Protein kinases are integral to the autophagy process. Atg1, the first autophagy-related protein identified, is a serine/threonine kinase and it is regulated by another serine/threonine kinase mTOR. Emerging studies suggest the participation of many different kinases in regulating various components/steps of this catabolic process. This review focuses on the regulation of autophagy by several kinases with particular emphasis on serine/threonine protein kinases such as mTOR, AMP-activated protein kinase, Akt, mitogen-activated protein kinase (ERK, p38 and JNK) and protein kinase C that are often deregulated in cancer and are important therapeutic targets.

  12. OAM mode converter in twisted fibers

    DEFF Research Database (Denmark)

    Usuga Castaneda, Mario A.; Beltran-Mejia, Felipe; Cordeiro, Cristiano;

    2014-01-01

    We analyze the case of an OAM mode converter based on a twisted fiber, through finite element simulations where we exploit an equivalence between geometric and material transformations. The obtained converter has potential applications in MDM. © 2014 OSA....

  13. Analysis Of Single Phase Matrix Converter

    OpenAIRE

    Divya Ahirrao; Bhagyashri Gaware

    2014-01-01

    This paper presents concept of single phase matrix converter. Single phase matrix converter (SPMC) performs a function such as frequency changer, rectifier, inverter; chopper. This reduces the need for new converter hardware. Pulse width modulation (SPWM) techniques are used to calculate the switch duty ratio to synthesis the output. The simulation of converter is carried out in MATLAB/SIMULINK. Hardware design is obtained using readily available IC‟s and other components. Thi...

  14. Simulation Results of Double Forward Converter

    OpenAIRE

    P. Vijaya Kumar; S. Rama Reddy

    2009-01-01

    This work aims to find a better forward converter for DC to DC conversion.Simulation of double forward converter in SMPS system is discussed in this paper. Aforward converter with RCD snubber to synchronous rectifier and/or to current doubleris also discussed. The evolution of the forward converter is first reviewed in a tutorialfashion. Performance parameters are discussed including operating principle, voltageconversion ratio, efficiency, device stress, small-signal dynamics, noise and EMI....

  15. Digital to Analog Converter Description

    OpenAIRE

    Tuijl, van, B.A.J.

    2003-01-01

    A circuit for analogue to digital or digital to analogue conversion comprising at least 2n matched current sources (40-1, 40-2, 40-n), where n is the resolution required of the conversion. Preferably more than 2n current sources (40-1, 40-2, 40-n) are used. The order in which the sources (40-1, 40-2, 40-n) are used may be changed in different samples. The current sources (40-1, 40-2, 40-n) may be replaced by one bit switched capacitor converters or by inverters connected to one end of a set o...

  16. Reliability of Wave Energy Converters

    DEFF Research Database (Denmark)

    Ambühl, Simon

    There are many different working principles for wave energy converters (WECs) which are used to produce electricity from waves. In order for WECs to become successful and more competitive to other renewable electricity sources, the consideration of the structural reliability of WECs is essential...... approach that includes uncertainties related to the limited amount of data and the considered models used to calculate the loads/stresses as well as uncertainties given by Mother Nature (e.g. inter-annual variation of extreme values) and measurement uncertainties. Due to limited amount of knowledge...

  17. Reliability of Wave Energy Converters

    DEFF Research Database (Denmark)

    Ambühl, Simon

    There are many different working principles for wave energy converters (WECs) which are used to produce electricity from waves. In order for WECs tobecome successful and more competitive to other renewable electricity sources,the consideration of the structural reliability of WECs is essential...... uncertaintiesrelated to the limited amount of data and the considered models used tocalculate the loads/stresses as well as uncertainties given by Mother Nature (e.g. inter-annual variation of extreme values) and measurement uncertainties. Due to limited amount of knowledge, reliability considerations for WEC...

  18. Power Converters and Power Quality

    CERN Document Server

    Kahle, K

    2015-01-01

    This paper discusses the subject of power quality for power converters. The first part gives an overview of most of the common disturbances and power quality issues in electrical networks for particle accelerators, and explains their consequences for accelerator operation. The propagation of asymmetrical network disturbances into a network is analysed. Quantitative parameters for network disturbances in a typical network are presented, and immunity levels for users’ electrical equipment are proposed. The second part of this paper discusses the technologies and strategies used in particle accelerator networks for power quality improvement . Particular focus is given to networks supplying loads with cycling active and reactive power

  19. Src mediates the mechanical activation of myogenesis by activating TNFα-converting enzyme

    OpenAIRE

    Niu, Airu; Wen, Yefei; Liu, Huijie; Zhan, Mei; Jin, Bingwen; Li, Yi-Ping

    2013-01-01

    Mechanical stimulation affects many biological aspects in living cells through mechanotransduction. In myogenic precursor cells (MPCs), mechanical stimulation activates p38 mitogen-activated protein kinase (MAPK), a key regulator of myogenesis, via activating TNFα-converting enzyme (TACE, also known as ADAM17), to release autocrine TNFα. However, the signaling mechanism of mechanical activation of TACE is unknown. Because TACE possesses the structural features of substrates of the non-recepto...

  20. Underwater noise from a wave energy converter

    DEFF Research Database (Denmark)

    Tougaard, Jakob

    A recent addition to the anthropogenic sources of underwater noise is offshore wave energy converters. Underwater noise was recorded from the Wavestar wave energy converter located at Hastholm, Denmark (57°7.73´N, 8°37.23´E). The Wavestar is a full-scale test and demonstration converter...

  1. Bacterial Protein-Tyrosine Kinases

    DEFF Research Database (Denmark)

    Shi, Lei; Kobir, Ahasanul; Jers, Carsten;

    2010-01-01

    in exopolysaccharide production, virulence, DNA metabolism, stress response and other key functions of the bacterial cell. BY-kinases act through autophosphorylation (mainly in exopolysaccharide production) and phosphorylation of other proteins, which have in most cases been shown to be activated by tyrosine......Bacteria and Eukarya share essentially the same family of protein-serine/threonine kinases, also known as the Hanks-type kinases. However, when it comes to protein-tyrosine phosphorylation, bacteria seem to have gone their own way. Bacterial protein-tyrosine kinases (BY-kinases) are bacterial...... and highlighted their importance in bacterial physiology. Having no orthologues in Eukarya, BY-kinases are receiving a growing attention from the biomedical field, since they represent a particularly promising target for anti-bacterial drug design....

  2. Map kinases in fungal pathogens.

    Science.gov (United States)

    Xu, J R

    2000-12-01

    MAP kinases in eukaryotic cells are well known for transducing a variety of extracellular signals to regulate cell growth and differentiation. Recently, MAP kinases homologous to the yeast Fus3/Kss1 MAP kinases have been identified in several fungal pathogens and found to be important for appressorium formation, invasive hyphal growth, and fungal pathogenesis. This MAP kinase pathway also controls diverse growth or differentiation processes, including conidiation, conidial germination, and female fertility. MAP kinases homologous to yeast Slt2 and Hog1 have also been characterized in Candida albicans and Magnaporthe grisea. Mutants disrupted of the Slt2 homologues have weak cell walls, altered hyphal growth, and reduced virulence. The Hog1 homologues are dispensable for growth but are essential for regulating responses to hyperosmotic stress in C. albicans and M. grisea. Overall, recent studies have indicated that MAP kinase pathways may play important roles in regulating growth, differentiation, survival, and pathogenesis in fungal pathogens. PMID:11273677

  3. Therapeutic targeting of Janus kinases

    OpenAIRE

    Pesu, Marko; Laurence, Arian; Kishore, Nandini; Zwillich, Sam; Chan, Gary; O’Shea, John J.

    2008-01-01

    Cytokines play pivotal roles in immunity and inflammation, and targeting cytokines and their receptors is an effective means of treating such disorders. Type I and II cytokine receptors associate with Janus family kinases (JAKs) to effect intracellular signaling. These structurally unique protein kinases play essential and specific roles in immune cell development and function. One JAK, JAK3, has particularly selective functions. Mutations of this kinase underlie severe combined immunodeficie...

  4. Visualizing autophosphorylation in histidine kinases

    OpenAIRE

    Casino, Patricia; Miguel-Romero, Laura; Marina, Alberto

    2014-01-01

    Reversible protein phosphorylation is the most widespread regulatory mechanism in signal transduction. Autophosphorylation in a dimeric sensor histidine kinase is the first step in two-component signalling, the predominant signal-transduction device in bacteria. Despite being the most abundant sensor kinases in nature, the molecular bases of the histidine kinase autophosphorylation mechanism are still unknown. Furthermore, it has been demonstrated that autophosphorylation can occur in two dir...

  5. Phosphatidylinositol 3-kinase in myogenesis.

    Science.gov (United States)

    Kaliman, P; Zorzano, A

    1997-08-01

    Phosphatidylinositol 3-kinase (PI 3-kinase) has been cloned and characterized in a wide range of organisms. PI 3-kinases are activated by a diversity of extracellular stimuli and are involved in multiple cell processes such as cell proliferation, protein trafficking, cell motility, differentiation, regulation of cytoskeletal structure, and apoptosis. It has recently been shown that PI 3-kinase is a crucial second messenger in the signaling of myogenesis. Two structurally unrelated highly specific inhibitors of PI 3-kinase-wortmannin and LY294002-block the morphological and biochemical differentiation program of different skeletal-muscle cell models. Moreover, L6E9 myoblasts overexpressing a dominant-negative mutant of PI 3-kinase p85 regulatory subunit (Δp85) are unable to differentiate. Furthermore, PI 3-kinase is specifically involved in the insulinlike growth factor (IGF)-dependent myogenic pathway. Indeed, the ability of IGF-I, des-1,3-IGF-I, and IGF-II to promote cell fusion and muscle-specific protein expression is impaired after treatment with PI 3-kinase inhibitors or in cells overexpressing Δp85. The identification of additional key downstream elements of the IGF/PI 3-kinase myogenic cascade is crucial to a detailed understanding of the process of muscle differentiation and may generate new tools for skeletal and cardiac muscle regeneration therapies. (Trends Cardiovasc Med 1997;7:198-202). © 1997, Elsevier Science Inc. PMID:21235885

  6. Reactive Power Compensation using a Matrix Converter

    OpenAIRE

    Holtsmark, Nathalie Marie-Anna

    2010-01-01

    This Master's thesis investigates a new application for the matrix converter: Shunt reactive power compensation. The suggested Matrix Converter-based Reactive power Compensation (MCRC) device is composed of a matrix converter, which input is connected to the grid and an electric machine at the output of the converter. The reactive power flowing in or out of the grid can be regulated with the matrix converter by controlling the magnitude and/or phase angle of the current at the input of the co...

  7. Valuing Convertible Bonds Based on LSRQM Method

    Directory of Open Access Journals (Sweden)

    Jian Liu

    2014-01-01

    Full Text Available Convertible bonds are one of the essential financial products for corporate finance, while the pricing theory is the key problem to the theoretical research of convertible bonds. This paper demonstrates how to price convertible bonds with call and put provisions using Least-Squares Randomized Quasi-Monte Carlo (LSRQM method. We consider the financial market with stochastic interest rates and credit risk and present a detailed description on calculating steps of convertible bonds value. The empirical results show that the model fits well the market prices of convertible bonds in China’s market and the LSRQM method is effective.

  8. Analysis Of Single Phase Matrix Converter

    Directory of Open Access Journals (Sweden)

    Divya Ahirrao

    2014-03-01

    Full Text Available This paper presents concept of single phase matrix converter. Single phase matrix converter (SPMC performs a function such as frequency changer, rectifier, inverter; chopper. This reduces the need for new converter hardware. Pulse width modulation (SPWM techniques are used to calculate the switch duty ratio to synthesis the output. The simulation of converter is carried out in MATLAB/SIMULINK. Hardware design is obtained using readily available IC‟s and other components. This paper discusses the new multiple converter for single phase input using matrix topology using just a single control logic.

  9. High-Performance Data Converters

    DEFF Research Database (Denmark)

    Steensgaard-Madsen, Jesper

    -order difference of the output signal from the loop filter's first integrator stage. This technique avoids the need for accurate matching of analog and digital filters that characterizes the MASH topology, and it preserves the signal-band suppression of quantization errors. Simulations show that quantizers...... in a standard CMOS technology, they can be designed to yield 100 dB performance at 10 times oversampling. The proposed scaled-element mismatch-shaping D/A converters are well suited for use as the feedback stage in oversampled delta-sigma quantizers. It is, however, not easy to make full use of their potential......, because that requires a high-resolution loop quantizer which introduces only a small delay. Generally, it is not acceptable to design the loop quantizer as a high-resolution flash quantizer because they require a large chip area and high power consumption. Pipeline techniques are proposed to circumvent...

  10. The SSG Wave Energy Converter

    DEFF Research Database (Denmark)

    Vicinanza, Diego; Margheritini, Lucia; Kofoed, Jens Peter;

    2012-01-01

    The Sea-wave Slot-cone Generator concept (SSG) is a Wave Energy Converter based on the wave overtopping principle utilizing several reservoirs placed on top of each other, in which the energy of the incoming wave will be stored as potential energy. The water captured in the reservoirs will then run...... through turbines for electricity production. The system utilizes a wide spectrum of different wave conditions by means of multiple reservoirs, located at different levels above the still water level. Thereby, it obtains a high overall efficiency and it can be suitable for shoreline and breakwater...... applications, presenting particular advantages such as: sharing structure costs, availability of grid connection and infrastructures, recirculation of water inside the harbor, as the outlet of the turbines is on the rear part of the system. Recently, plans for the SSG pilot installation were in progress...

  11. Converting pest insects into food

    DEFF Research Database (Denmark)

    Offenberg, Hans Joachim; Wiwatwittaya, Decha

    2010-01-01

    by pest insects, problematic pests are converted into food and additional earnings. To assess the profitability of providing additional food for the ants, O. smaragdina food conversion efficiency (ECI) was estimated in the laboratory. This estimate suggests the feeding of weaver ants in ant farms......Canopy dwelling weaver ants (Oecophylla spp.) are used to control a variety of pests in a number of tropical tree crops. What is less familiar is the existence of commercial markets where these ants and their brood are sold for (i) human consumption, (ii) pet food or (iii) traditional medicine...... on management, 32-115 kg ant brood (mainly new queens) was harvested per ha per year without detrimental effect on colony survival and worker ant densities. This suggest that ant biocontrol and ant harvest can be sustainable integrated in plantations and double benefits derived. As ant production is fuelled...

  12. Three-phase AC-AC power converters based on matrix converter topology matrix-reactance frequency converters concept

    CERN Document Server

    Szczesniak, Pawel

    2013-01-01

    AC voltage frequency changes is one of the most important functions of solid state power converters. The most desirable features in frequency converters are the ability to generate load voltages with arbitrary amplitude and frequency, sinusoidal currents and voltages waveforms; the possibility of providing unity power factor for any load; and, finally, a simple and compact power circuit. Over the past decades, a number of different frequency converter topologies have appeared in the literature, but only the converters with either a voltage or current DC link are commonly used in industrial app

  13. Radiation-Tolerant DC-DC Converters

    Science.gov (United States)

    Skutt, Glenn; Sable, Dan; Leslie, Leonard; Graham, Shawn

    2012-01-01

    A document discusses power converters suitable for space use that meet the DSCC MIL-PRF-38534 Appendix G radiation hardness level P classification. A method for qualifying commercially produced electronic parts for DC-DC converters per the Defense Supply Center Columbus (DSCC) radiation hardened assurance requirements was developed. Development and compliance testing of standard hybrid converters suitable for space use were completed for missions with total dose radiation requirements of up to 30 kRad. This innovation provides the same overall performance as standard hybrid converters, but includes assurance of radiation- tolerant design through components and design compliance testing. This availability of design-certified radiation-tolerant converters can significantly reduce total cost and delivery time for power converters for space applications that fit the appropriate DSCC classification (30 kRad).

  14. Converting Relational Database Into Xml Document

    Directory of Open Access Journals (Sweden)

    Kanagaraj.S

    2012-03-01

    Full Text Available XML (Extensible Markup Language is emerging and gradually accepted as the standard for data interchange in the Internet world. Interoperation of relational database and XML database involves schema and data translations. Through EER (extended entity relationship model can convert the schema of relational database into XML. The semantics of the relational database, captured in EER diagram, are mapped to XML schema using stepwise procedures and mapped to XML document under the definitions of the XML schema. Converting Relational Database into XML Document is a process of converting the existing databases into XML file format. Existing conversion techniques convert a single database into xml. The proposed approach performs the conversion of databases like Ms-Access, MS-SQL to XML file format. Read the tables information from the corresponding database and generate code for the appropriate databases and convert the tables into XML flat file format. This converted XML file is been presented to the user.

  15. High Efficiency Reversible Fuel Cell Power Converter

    DEFF Research Database (Denmark)

    Pittini, Riccardo

    entitled "High Efficiency Reversible Fuel Cell Power Converter" and it presents the design of a high efficiency dc-dc converter developed and optimized for bidirectional fuel cell applications. First, a brief overview of fuel cell and energy storage technologies is presented. Different system topologies...... as well as different dc-ac and dc-dc converter topologies are presented and analyzed. A new ac-dc topology for high efficiency data center applications is proposed and an efficiency characterization based on the fuel cell stack I-V characteristic curve is presented. The second part discusses the main...... of magnetic components especially for large production volumes. At last, the complete converter design is presented in detailed and characterized in efficiency terms. Both benefits, provided by SiC power devices and by a redesign of the converter layout increased the converter power density up to 2.2 k...

  16. Efficient Implementation of Sample Rate Converter

    OpenAIRE

    Charanjit singh; Manjeet Singh patterh; Sanjay Sharma

    2011-01-01

    Within wireless base station system design, manufacturers continue to seek ways to add value and performance while increasing differentiation. Transmit/receive functionality has become an area of focus as designers attempt to address the need to move data from very high frequency sample rates to chip processing rates. Digital Up Converter (DUC) and Digital Down Converter (DDC) are used as sample rate converters. These are the important block in every digital communication system; hence there ...

  17. Silicon waveguide based TE mode converter.

    Science.gov (United States)

    Zhang, Jing; Liow, Tsung-Yang; Yu, Mingbin; Lo, Guo-Qiang; Kwong, Dim-Lee

    2010-11-22

    A silicon waveguide based TE mode converter was designed for the mode conversion between a horizontal waveguide and vertical waveguide in the two-layer structure waveguide based polarization diversity circuit. The TE mode converter's performance was studied. The polarization mode converter with minimum length of 5 μm was demonstrated to provide the TE mode conversion while maintaining the polarization status. The insertion loss at the transition region was less than 2 dB. PMID:21164874

  18. Ocean floor mounting of wave energy converters

    Science.gov (United States)

    Siegel, Stefan G

    2015-01-20

    A system for mounting a set of wave energy converters in the ocean includes a pole attached to a floor of an ocean and a slider mounted on the pole in a manner that permits the slider to move vertically along the pole and rotate about the pole. The wave energy converters can then be mounted on the slider to allow adjustment of the depth and orientation of the wave energy converters.

  19. Estimating the temperature of a catalytic converter

    Energy Technology Data Exchange (ETDEWEB)

    Ma, T.T.-H.

    1994-11-02

    A method is described for estimating the temperature in a catalytic converter used in the exhaust system of an internal combustion engine. Pressure sensors monitor the flow resistance across the catalytic converter to provide an indication of the temperature inside. This feedback system allows heating devices to be switched off and thus avoid overheating, while maintaining the catalytic converter's efficiency by assuring that it does not operate below its light off temperature. (UK)

  20. Estimating the temperature of a catalytic converter

    Energy Technology Data Exchange (ETDEWEB)

    Ma, T.T.-H.

    1994-11-02

    A method of estimating the temperature of a catalytic converter used in the exhaust system of an internal combustion engine is described. Heated exhaust gas oxygen (HEGO) sensors are placed upstream and downstream of the catalytic converter. The temperature of the catalytic converter shortly after start-up is measured by monitoring the resistance of the HEGO sensor's heating element. The downstream sensor is used for mixture control and to double check results of the upstream sensor. (UK)

  1. Timing of Convertible Debt Financing and Investment

    OpenAIRE

    Kyoko Yagi; Ryuta Takashima; Hiroshi Takamori; Katsushige Sawaki

    2008-01-01

    In this paper, we examine the optimal investment policy of the firm which is financed by issuing equity, straight debt and convertible debt. We extend the model in Mauer and Sarkar (2005) over financing with convertible debt. We examine two different investment policies that maximize the equity value and the firm value and show the agency cost as the difference between each policy value. Furthermore, we investigate how the issuance of convertible debt affects investment.

  2. Regeneration of ZVS converter with Resonant inductor

    Directory of Open Access Journals (Sweden)

    J.Sivavara Prasad

    2011-09-01

    Full Text Available This paper presents an analysis of the regeneration of zero-voltage-switching converter with resonant inductor, quasi-resonant converters, and full-bridge zero-voltage-switched PWM Converter. The design of a clamping circuit considering a saturable resonant inductor is presented and compared with the design of a clamping circuit with a linear resonant inductor. A diode model with reverse recovery is employed to simulate the effects.

  3. Commutation Processes in Multiresonant ZVS Bridge Converter

    Directory of Open Access Journals (Sweden)

    Miroslaw Luft

    2008-01-01

    Full Text Available The analysis of the multiresonant ZVS DC/DC bridge converter is presented. The control system of the converter is basedon the method of frequency control at the constant time of transistor turn-off with a phase shift. The operation of the circuit is givenand the operating range of the converter is defined where ZVS switching operation is assured. Control characteristics are given andthe converter’s efficiency is defined. The circuit’s operation is analysed on the basis of results of the converter simulation tests using Simplorer programme.

  4. Vacuum-insulated catalytic converter

    Energy Technology Data Exchange (ETDEWEB)

    Benson, David K. (Golden, CO)

    2001-01-01

    A catalytic converter has an inner canister that contains catalyst-coated substrates and an outer canister that encloses an annular, variable vacuum insulation chamber surrounding the inner canister. An annular tank containing phase-change material for heat storage and release is positioned in the variable vacuum insulation chamber a distance spaced part from the inner canister. A reversible hydrogen getter in the variable vacuum insulation chamber, preferably on a surface of the heat storage tank, releases hydrogen into the variable vacuum insulation chamber to conduct heat when the phase-change material is hot and absorbs the hydrogen to limit heat transfer to radiation when the phase-change material is cool. A porous zeolite trap in the inner canister absorbs and retains hydrocarbons from the exhaust gases when the catalyst-coated substrates and zeolite trap are cold and releases the hydrocarbons for reaction on the catalyst-coated substrate when the zeolite trap and catalyst-coated substrate get hot.

  5. MAP Kinases in Immune Responses

    Institute of Scientific and Technical Information of China (English)

    Yongliang Zhang; Chen Dong

    2005-01-01

    MAP kinases are evolutionarily conserved signaling regulators from budding yeast to mammals and play essential roles in both innate and adaptive immune responses. There are three main families of MAPKs in mammals. Each of them has its own activators, inactivators, substrates and scaffolds, which altogether form a fine signaling network in response to different extracellular or intracellular stimulation. In this review, we summarize recent advances in understanding of the regulation of MAP kinases and the roles of MAP kinases in innate and adaptive immune responses.

  6. MAP Kinases in Immune Responses

    Institute of Scientific and Technical Information of China (English)

    YongliangZhang; ChenDong

    2005-01-01

    MAP kinases are evolutionarily conserved signaling regulators from budding yeast to mammals and play essential roles in both innate and adaptive immune responses. There are three main families of MAPKs in mammals. Each of them has its own activators, inactivators, substrates and scaffolds, which altogether form a fine signaling network in response to different extracellular or intracellular stimulation. In this review, we summarize recent advances in understanding of the regulation of MAP kinases and the roles of MAP kinases in innate and adaptive immune responses. Cellular & Molecular Immunology. 2005;2(1):20-27.

  7. Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

    Science.gov (United States)

    Eldar-Finkelman, Hagit; Krebs, Edwin G.

    1997-01-01

    The phosphorylation of insulin receptor substrate 1 (IRS-1) on tyrosine residues by the insulin receptor (IR) tyrosine kinase is involved in most of the biological responses of insulin. IRS-1 mediates insulin signaling by recruiting SH2 proteins through its multiple tyrosine phosphorylation sites. The phosphorylation of IRS-1 on serine/threonine residues also occurs in cells; however, the particular protein kinase(s) promoting this type of phosphorylation are unknown. Here we report that glycogen synthase kinase 3 (GSK-3) is capable of phosphorylating IRS-1 and that this modification converts IRS-1 into an inhibitor of IR tyrosine kinase activity in vitro. Expression of wild-type GSK-3 or an “unregulated” mutant of the kinase (S9A) in CHO cells overexpressing IRS-1 and IR, resulted in increased serine phosphorylation levels of IRS-1, suggesting that IRS-1 is a cellular target of GSK-3. Furthermore, insulin-induced tyrosine phosphorylation of IRS-1 and IR was markedly suppressed in cells expressing wild-type or the S9A mutant, indicating that expression of GSK-3 impairs IR tyrosine kinase activity. Taken together, our studies suggest a new role for GSK-3 in attenuating insulin signaling via its phosphorylation of IRS-1 and may provide new insight into mechanisms important in insulin resistance. PMID:9275179

  8. Catalytic converter with thermoelectric generator

    Energy Technology Data Exchange (ETDEWEB)

    Parise, R.J.

    1998-07-01

    The unique design of an electrically heated catalyst (EHC) and the inclusion of an ECO valve in the exhaust of an internal combustion engine will meet the strict new emission requirements, especially at vehicle cold start, adopted by several states in this country as well as in Europe and Japan. The catalytic converter (CC) has been a most useful tool in pollution abatement for the automobile. But the emission requirements are becoming more stringent and, along with other improvements, the CC must be improved to meet these new standards. Coupled with the ECO valve, the EHC can meet these new emission limits. In an internal combustion engine vehicle (ICEV), approximately 80% of the energy consumed leaves the vehicle as waste heat: out the tail pipe, through the radiator, or convected/radiated off the engine. Included with the waste heat out the tail pipe are the products of combustion which must meet strict emission requirements. The design of a new CC is presented here. This is an automobile CC that has the capability of producing electrical power and reducing the quantity of emissions at vehicle cold start, the Thermoelectric Catalytic Power Generator. The CC utilizes the energy of the exothermic reactions that take place in the catalysis substrate to produce electrical energy with a thermoelectric generator. On vehicle cold start, the thermoelectric generator is used as a heat pump to heat the catalyst substrate to reduce the time to catalyst light-off. Thus an electrically heated catalyst (EHC) will be used to augment the abatement of tail pipe emissions. Included with the EHC in the exhaust stream of the automobile is the ECO valve. This valve restricts the flow of pollutants out the tail pipe of the vehicle for a specified amount of time until the EHC comes up to operating temperature. Then the ECO valve opens and allows the full exhaust, now treated by the EHC, to leave the vehicle.

  9. Protein Crystals of Raf Kinase

    Science.gov (United States)

    1995-01-01

    This image shows crystals of the protein raf kinase grown on Earth (photo a) and on USML-2 (photo b). The space-grown crystals are an order of magnitude larger. Principal Investigator: Dan Carter of New Century Pharmaceuticals

  10. Passive Resonant Bidirectional Converter with Galvanic Barrier

    Science.gov (United States)

    Rosenblad, Nathan S. (Inventor)

    2014-01-01

    A passive resonant bidirectional converter system that transports energy across a galvanic barrier includes a converter using at least first and second converter sections, each section including a pair of transfer terminals, a center tapped winding; a chopper circuit interconnected between the center tapped winding and one of the transfer terminals; an inductance feed winding interconnected between the other of the transfer terminals and the center tap and a resonant tank circuit including at least the inductance of the center tap winding and the parasitic capacitance of the chopper circuit for operating the converter section at resonance; the center tapped windings of the first and second converter sections being disposed on a first common winding core and the inductance feed windings of the first and second converter sections being disposed on a second common winding core for automatically synchronizing the resonant oscillation of the first and second converter sections and transferring energy between the converter sections until the voltage across the pairs of transfer terminals achieves the turns ratio of the center tapped windings.

  11. Multilevel converters for 10 MW Wind Turbines

    DEFF Research Database (Denmark)

    Ma, Ke; Blaabjerg, Frede

    2011-01-01

    Several promising multi-level converter configurations for 10 MW Wind Turbines both with direct drive and one-stage gear box drive using Permanent Magnet Synchronous Generator (PMSG) are proposed, designed and compared. Reliability is a crucial indicator for large scale wind power converters...

  12. Power Converters Secure Electronics in Harsh Environments

    Science.gov (United States)

    2013-01-01

    In order to harden power converters for the rigors of space, NASA awarded multiple SBIR contracts to Blacksburg, Virginia-based VPT Inc. The resulting hybrid DC-DC converters have proven valuable in aerospace applications, and as a result the company has generated millions in revenue from the product line and created four high-tech jobs to handle production.

  13. Switched-mode converters (one quadrant)

    CERN Document Server

    Barrade, P

    2006-01-01

    Switched-mode converters are DC/DC converters that supply DC loads with a regulated output voltage, and protection against overcurrents and short circuits. These converters are generally fed from an AC network via a transformer and a conventional diode rectifier. Switched-mode converters (one quadrant) are non-reversible converters that allow the feeding of a DC load with unipolar voltage and current. The switched-mode converters presented in this contribution are classified into two families. The first is dedicated to the basic topologies of DC/DC converters, generally used for low- to mid-power applications. As such structures enable only hard commutation processes, the main drawback of such topologies is high commutation losses. A typical multichannel evolution is presented that allows an interesting decrease in these losses. Deduced from this direct DC/DC converter, an evolution is also presented that allows the integration of a transformer into the buck and the buck–boost structure. This enables an int...

  14. Modeling and Simulation of Matrix Converter

    DEFF Research Database (Denmark)

    Liu, Fu-rong; Klumpner, Christian; Blaabjerg, Frede

    2005-01-01

    This paper discusses the modeling and simulation of matrix converter. Two models of matrix converter are presented: one is based on indirect space vector modulation and the other is based on power balance equation. The basis of these two models is• given and the process on modeling is introduced in...

  15. High Precision Current Measurement for Power Converters

    CERN Document Server

    Cerqueira Bastos, M

    2015-01-01

    The accurate measurement of power converter currents is essential to controlling and delivering stable and repeatable currents to magnets in particle accelerators. This paper reviews the most commonly used devices for the measurement of power converter currents and discusses test and calibration methods.

  16. High Precision Current Measurement for Power Converters

    OpenAIRE

    Bastos, M. Cerqueira

    2016-01-01

    The accurate measurement of power converter currents is essential to controlling and delivering stable and repeatable currents to magnets in particle accelerators. This paper reviews the most commonly used devices for the measurement of power converter currents and discusses test and calibration methods.

  17. Selective harmonic control for power converters

    DEFF Research Database (Denmark)

    Zhou, Keliang; Yang, Yongheng; Blaabjerg, Frede;

    2014-01-01

    This paper proposes an Internal Model Principle (IMP) based Selective Harmonic Controller (SHC) for power converters. The proposed SHC offers an optimal control solution for power converters to mitigate power harmonics. It makes a good trade-off among cost, complexity and performance. It has high...

  18. Present trends in HVDC converter station design

    Energy Technology Data Exchange (ETDEWEB)

    Carlsson, Lennart; Asplund, Gunnar; Bjorklund, Hans; Flisberg, Gunnar [ABB Power Systems AB, Ludvika (Sweden)

    1994-12-31

    HVDC converter station technology has developed rapidly to satisfy increasing requirements during past 10 - 15 years, but there has not been any dramatic changes since thyristor valves were introduced in the mid 70s. This paper describes some recent and expected future developments, that will substantiality change and simplify future converter stations. (author) 4 refs., 7 figs.

  19. Radiation Effects on DC-DC Converters

    Science.gov (United States)

    Zhang, De-Xin; AbdulMazid, M. D.; Attia, John O.; Kankam, Mark D. (Technical Monitor)

    2001-01-01

    In this work, several DC-DC converters were designed and built. The converters are Buck Buck-Boost, Cuk, Flyback, and full-bridge zero-voltage switched. The total ionizing dose radiation and single event effects on the converters were investigated. The experimental results for the TID effects tests show that the voltages of the Buck Buck-Boost, Cuk, and Flyback converters increase as total dose increased when using power MOSFET IRF250 as a switching transistor. The change in output voltage with total dose is highest for the Buck converter and the lowest for Flyback converter. The trend of increase in output voltages with total dose in the present work agrees with those of the literature. The trends of the experimental results also agree with those obtained from PSPICE simulation. For the full-bridge zero-voltage switch converter, it was observed that the dc-dc converter with IRF250 power MOSFET did not show a significant change of output voltage with total dose. In addition, for the dc-dc converter with FSF254R4 radiation-hardened power MOSFET, the output voltage did not change significantly with total dose. The experimental results were confirmed by PSPICE simulation that showed that FB-ZVS converter with IRF250 power MOSFET's was not affected with the increase in total ionizing dose. Single Event Effects (SEE) radiation tests were performed on FB-ZVS converters. It was observed that the FB-ZVS converter with the IRF250 power MOSFET, when the device was irradiated with Krypton ion with ion-energy of 150 MeV and LET of 41.3 MeV-square cm/mg, the output voltage increased with the increase in fluence. However, for Krypton with ion-energy of 600 MeV and LET of 33.65 MeV-square cm/mg, and two out of four transistors of the converter were permanently damaged. The dc-dc converter with FSF254R4 radiation hardened power MOSFET's did not show significant change at the output voltage with fluence while being irradiated by Krypton with ion energy of 1.20 GeV and LET of 25

  20. SPECTRAL ANALYSIS OF BUCK AND SEPIC CONVERTERS

    Directory of Open Access Journals (Sweden)

    CHAKIB ALAOUI

    2011-02-01

    Full Text Available Switched mode power converters generate harmonic currents, which will be injected into the utility grid, causing distortion of the utility waveform. They also become a source for the generation of EMI, which may affect the communication systems. This work is about the design and evaluation of the two most frequently used SMPS used in step down mode of operation: the Buck converter and the Sepic converter working in step-down mode of operation. These converters were designed using optimized equations for their components ratings. Simulation results show that although the Buck output voltage is low in harmonics, it has high harmonic contents in currents circulating in its inductor and diode, and hence requires strong filtering. The Sepic converterhas lower harmonic contents than the Buck converter.

  1. Switched Mode Four-Quadrant Converters

    CERN Document Server

    Thurel, Y

    2015-01-01

    This paper was originally presented at CAS-2004, and was slightly modified for CAS-2014. It presents a review of the key parameters that impact the design choices for a true four-quadrant power converter, in the range 1-10 kW, mainly based on switching mode converter topology. This paper will first describe the state-of-the-art for this power converter family, giving the drawbacks and advantages of different possible solutions. It will also present practical results obtained from the CERN-designed converter. It will finally give some important tips regarding critical phases like test one, when conducting a project dealing with this type of power converter.

  2. Reliability of Power Electronic Converter Systems

    DEFF Research Database (Denmark)

    The main aims of power electronic converter systems (PECS) are to control, convert, and condition electrical power flow from one form to another through the use of solid-state electronics. This book outlines current research into the scientific modeling, experimentation, and remedial measures...... electronic converter systems; anomaly detection and remaining-life prediction for power electronics; reliability of DC-link capacitors in power electronic converters; reliability of power electronics packaging; modeling for life-time prediction of power semiconductor modules; minimization of DC......-link capacitance in power electronic converter systems; wind turbine systems; smart control strategies for improved reliability of power electronics system; lifetime modelling; power module lifetime test and state monitoring; tools for performance and reliability analysis of power electronics systems; fault...

  3. PERFORMANCE ANALYSIS OF 2D CONVERTER BY COMBINING SR & KY CONVERTERS

    Directory of Open Access Journals (Sweden)

    V. Manoj Kumar

    2014-03-01

    Full Text Available Most of the portable equipments use battery as power source. The increasing use of low voltage portable devices and growing requirements of functionalities embedded into such devices. Thus an efficient power management technique is needed for longer battery life for them. Highly variable nature of batteries systems often require supply voltages to be both higher and lower than the battery. This is most efficiently generated by a buck-boost switching converter. But here the converter efficiency is decreased since the power loss occurs in the storage devices. Step by step, process of designing, feedback control and simulation of a novel voltage-buck boost converter, combining KY and synchronous Rectifier buck converter for battery power applications. Unlike the traditional buck–boost converter, this converter has the positive output voltage and system is stable, different from the negative output voltage and low stable of the traditional inverting buck–boost converters. Since such a converter operates in continuous conduction mode. Also it possesses the non-pulsating output current, thereby not only decreasing the current stress on the output capacitor but also reducing the output voltage ripple. Both the KY converter and the synchronous buck converter, combined into a positive buck– boost converter, uses the same power switches. Here it makes the circuit to be compact and the corresponding cost to be down. Voltage conversion ratio is 2D,so it is also called 2D converter.

  4. Boost matrix converters in clean energy systems

    Science.gov (United States)

    Karaman, Ekrem

    This dissertation describes an investigation of novel power electronic converters, based on the ultra-sparse matrix topology and characterized by the minimum number of semiconductor switches. The Z-source, Quasi Z-source, Series Z-source and Switched-inductor Z-source networks were originally proposed for boosting the output voltage of power electronic inverters. These ideas were extended here on three-phase to three-phase and three-phase to single-phase indirect matrix converters. For the three-phase to three-phase matrix converters, the Z-source networks are placed between the three-switch input rectifier stage and the output six-switch inverter stage. A brief shoot-through state produces the voltage boost. An optimal pulse width modulation technique was developed to achieve high boosting capability and minimum switching losses in the converter. For the three-phase to single-phase matrix converters, those networks are placed similarly. For control purposes, a new modulation technique has been developed. As an example application, the proposed converters constitute a viable alternative to the existing solutions in residential wind-energy systems, where a low-voltage variable-speed generator feeds power to the higher-voltage fixed-frequency grid. Comprehensive analytical derivations and simulation results were carried out to investigate the operation of the proposed converters. Performance of the proposed converters was then compared between each other as well as with conventional converters. The operation of the converters was experimentally validated using a laboratory prototype.

  5. Electromagnetic Compatibility of Matrix Converter System

    Directory of Open Access Journals (Sweden)

    S. Fligl

    2006-12-01

    Full Text Available The presented paper deals with matrix converters pulse width modulation strategies design with emphasis on the electromagnetic compatibility. Matrix converters provide an all-silicon solution to the problem of converting AC power from one frequency to another, offering almost all the features required of an ideal static frequency changer. They possess many advantages compared to the conventional voltage or current source inverters. A matrix converter does not require energy storage components as a bulky capacitor or an inductance in the DC-link, and enables the bi-directional power flow between the power supply and load. The most of the contemporary modulation strategies are able to provide practically sinusoidal waveforms of the input and output currents with negligible low order harmonics, and to control the input displacement factor. The perspective of matrix converters regarding EMC in comparison with other types of converters is brightly evident because it is no need to use any equipment for power factor correction and current and voltage harmonics reduction. Such converter with proper control is properly compatible both with the supply mains and with the supplied load. A special digital control system was developed for the realized experimental test bed which makes it possible to achieve greater throughput of the digital control system and its variability.

  6. Acoustics of automotive catalytic converter assemblies

    Science.gov (United States)

    Dickey, Nolan S.; Selamet, Ahmet; Parks, Steve J.; Tallio, Kevin V.; Miazgowicz, Keith D.; Radavich, Paul M.

    2003-10-01

    In an automotive exhaust system, the purpose of the catalytic converter is to reduce pollutant emissions. However, catalytic converters also affect the engine and exhaust system breathing characteristics; they increase backpressure, affect exhaust system acoustic characteristics, and contribute to exhaust manifold tuning. Thus, radiated sound models should include catalytic converters since they can affect both the source characteristics and the exhaust system acoustic behavior. A typical catalytic converter assembly employs a ceramic substrate to carry the catalytically active noble metals. The substrate has numerous parallel tubes and is mounted in a housing with swelling mat or wire mesh around its periphery. Seals at the ends of the substrate can be used to help force flow through the substrate and/or protect the mat material. Typically, catalytic converter studies only consider sound propagation in the small capillary tubes of the substrate. Investigations of the acoustic characteristics of entire catalytic converter assemblies (housing, substrate, seals, and mat) do not appear to be available. This work experimentally investigates the acoustic behavior of catalytic converter assemblies and the contributions of the separate components to sound attenuation. Experimental findings are interpreted with respect to available techniques for modeling sound propagation in ceramic substrates.

  7. Propagation characteristics of converted refracted wave and its application in static correction of converted wave

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Three-component seismic exploration through P-wave source and three-component geophone is an effective technique used in complicated reservoir exploration. In three-component seismic exploration data processing,one of the difficulties is static correction of converted wave. This paper analyzes propagation characteristics of non-converted and converted refracted waves,and discovers a favor-able condition for the formation of converted refracted wave,i.e. the velocity of overlaying medium S wave is much lower than that of underlying medium S wave. In addition,the paper proposes the static correction method of converted wave based on PPS converted refracted wave,and processes the real three-component seismic data with better results of static correction of converted wave.

  8. Application of AGPU for Matrix Converters

    Directory of Open Access Journals (Sweden)

    Nithin T Abraham

    2014-07-01

    Full Text Available A simple PI control loop for the matrix converter system is designed in the simulation to maintain a constant output voltage inspite of any disturbance in the source. The single phase matrix converter employs a modified safe-commutation strategy, which results in the elimination of voltage spikes on switches, without the need of a snubber circuit when there is an inductive load being utilized. This is facilitated through the proper switching control algorithm. The sine PWM pulses are generated as switching pulses to the converter to reduce the THD.

  9. Matrix laser IR-visible image converter

    International Nuclear Information System (INIS)

    A new type of a focal matrix IR-visible image converter is proposed. The pixel IR detectors of the matrix are tunable microcavities of VCSEL (vertical-cavity surface emitting laser) semiconductor microstructures. The image conversion is performed due to the displacements of highly reflecting cavity mirrors caused by thermoelastic stresses in their microsuspensions appearing upon absorption of IR radiation. Analysis of the possibilities of the converter shows that its sensitivity is 10-3-10-2 K and the time response is 10-4-10-3 s. These characteristics determine the practical application of the converter. (laser applications and other topics in quantum electronics)

  10. Data Converter for Multistandard Mobile Phones

    DEFF Research Database (Denmark)

    Yurttas, Aziz; Bruun, Erik; Jensen, Rasmus Glarborg

    2004-01-01

    This paper describes an analog to digital converter (ADC) for mobile communication systems using a direct down conversion architecture. The ADC can be programmed to meet the requirements of different communication standards, including GSM (Global System for Mobile communication) and WCDMA (Wideband...... Code Division Multiple Access). The ADC is realized with a pipeline ADC architecture for WCDMA and a Sigma-Delta architecture for GSM. In order to have an optimized area and power consumption, the basic building blocks (opamps) of the converters are shared between the two converter architectures...

  11. Spectral Analysis of Sample Rate Converter

    Directory of Open Access Journals (Sweden)

    Manish Sabraj

    2010-10-01

    Full Text Available The aim of digital sample rate conversion is to bring a digital audio signal from one sample frequency to another. The distortion of the audio signal introduced by the sample rate converter should be as low as possible. The generation of the output samples from the input samples may be performed by the application of various methods. In this paper, a new technique of digital sample-rate converter is proposed. We perform the spectral analysis of proposed digital sample rate converter.

  12. Converters for Distributed Power Generation Systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Yang, Yongheng

    2015-01-01

    presents an overview of the power converters for the DPGS, mainly based on wind turbine systems and photovoltaic systems, covering a wide range of applications. Moreover, the modulation schemes and interfacing power filters for the power converters are also exemplified. Finally, the general control......Power electronics technology has become the enabling technology for the integration of distributed power generation systems (DPGS) such as offshore wind turbine power systems and commercial photovoltaic power plants. Depending on the applications, a vast array of DPGS-based power converter...

  13. Reliability of power electronic converter systems

    CERN Document Server

    Chung, Henry Shu-hung; Blaabjerg, Frede; Pecht, Michael

    2016-01-01

    This book outlines current research into the scientific modeling, experimentation, and remedial measures for advancing the reliability, availability, system robustness, and maintainability of Power Electronic Converter Systems (PECS) at different levels of complexity.

  14. Energy saving dc-dc converter circuit

    International Nuclear Information System (INIS)

    An energy saving dc-dc converter circuit is disclosed having two energy efficient means which operate in tandem, an energy conserving means and a voltage doubling means. These energy efficient means are applied in combination with elements commonly found in dc-dc converter circuits, namely an ac voltage generator, a transformer for stepping up the generated ac voltage, and means for storing the converted dc voltage. The energy conserving means is connected to the dc voltage storage means. It comprises a resettable inhibit circuit which cuts off the provision of dc voltage for conversion for a predetermined interval when the output of the converter exceeds a predetermined level. The voltage doubling means is reponsive to outputs of the inhibit circuit of the energy conserving means and the ac voltage generator. It provides a phase inverted waveform of the generated ac voltage on one of two leads to the ac voltage step-up transformer

  15. Input-output rearrangement of isolated converters

    DEFF Research Database (Denmark)

    Madsen, Mickey Pierre; Kovacevic, Milovan; Mønster, Jakob Døllner;

    2015-01-01

    This paper presents a new way of rearranging the input and output of isolated converters. The new arrangement posses several advantages, as increased voltage range, higher power handling capabilities, reduced voltage stress and improved efficiency, for applications where galvanic isolation...

  16. Interface of magnetoresistive converter of active power

    Directory of Open Access Journals (Sweden)

    A. I. Vytiaganets

    2009-10-01

    Full Text Available The vehicle and programmatic interfaces of magnetoresistive converter of active power are considered, the results of statistical treatment of the multiple measuring of active-power are analysed.

  17. Converter station of Juebek; Umrichterwerk Juebek

    Energy Technology Data Exchange (ETDEWEB)

    Zimmert, G. [AEG Bahnfahrwegsysteme GmbH, Frankfurt am Main (Germany); Scheuring, J. [AEG Bahnfahrwegsysteme GmbH, Frankfurt am Main (Germany); Werth, L. [AEG Bahnfahrwegsysteme GmbH, Frankfurt am Main (Germany); Koeltzsch, W. [Deutsche Bahn AG, Hamburg (Germany); Niehage, H. [AEG Anlagen- und Antriebssysteme GmbH, Berlin (Germany); Tadros, Y. [Daimler Benz AG, Berlin (Germany). Forschungsinstitut fuer Antriebstechnik und Leistungselektronik

    1995-09-01

    Most northern electrified lines in Schleswig-Holstein will be supplied with a.c. 16 2/3 Hz 15 kV traction energy from de-central converter station of Juebek which is under construction as a turn-key project. Converter technology based on semiconductor power elements will replace the conventional technology of rotating converters in the future. The paper gives a survey about importance and conception of Juebek converter station, incorporated technology and its state of construction. (orig.) [Deutsch] Zur Bahnenergieversorgung des noerdlichsten Bereiches der elektrifizierten Strecken in Schleswig-Holstein mit AC 16 2/3 Hz 15 kV wird zur Zeit das dezentrale Umrichterwerk Juebek als schluesselfertige Anlage errichtet. Die Umrichtertechnik auf der Basis leistungselektronischer Stromrichter wird in den kommenden Jahren die bisherige Maschinenumformertechnik abloesen. Der Beitrag gibt einen Ueberblick ueber die Bedeutung und das Konzept des Umrichterwerkes Juebek, die eingesetzte Technik und den Stand des Bauablaufes. (orig.)

  18. Three-phase Resonant DC-link Converter

    DEFF Research Database (Denmark)

    Munk-Nielsen, Stig

    The purpose of the project is to develop a three-phase resonant converter suitable for standard speed drives. The motivation for working with resonant converters is found in the problem of the standard converter type used today. In standard converter type Pulse Width Modulated-Voltage Source...... frequency three phase parallel resonant converter is realized....

  19. A Multiport Isolated DC-DC Converter

    OpenAIRE

    Tran, Yan-Kim; Dujic, Drazen

    2016-01-01

    This paper presents a multi-port isolated DC-DC converter for DC applications. A three-port structure is presented, characterized with full bidirectional power flow and simple control. Galvanic isolation is achieved by means of a multi-winding medium frequency transformer which is a part of a resonant LLC converter. To provide controllable power exchange with external DC ports, two out of three ports are equipped with additional bidirectional buck/boost stages. They serve to provide active po...

  20. AC – AC Converters for UPS

    Directory of Open Access Journals (Sweden)

    Rusalin Lucian R. Păun

    2008-05-01

    Full Text Available This paper propose a new control technique forsingle – phase AC – AC converters used for a on-line UPSwith a good dynamic response, a reduced-partscomponents, a good output characteristic, a good powerfactorcorrection(PFC. This converter no needs anisolation transformer. A power factor correction rectifierand an inverter with the proposed control scheme has beendesigned and simulated using Caspoc2007, validating theconcept.

  1. Torus bifurcations in multilevel converter systems

    DEFF Research Database (Denmark)

    Zhusubaliyev, Zhanybai T.; Mosekilde, Erik; Yanochkina, Olga O.

    2011-01-01

    This paper considers the processes of torus formation and reconstruction through smooth and nonsmooth bifurcations in a pulse-width modulated DC/DC converter with multilevel control. When operating in a regime of high corrector gain, converters of this type can generate structures of stable tori....... The paper also demonstrates how pairs of attracting and repelling tori emerge through border-collision torus-birth and border-collision torus-fold bifurcations. © 2011 World Scientific Publishing Company....

  2. Mathematical efficiency modeling of static power converters

    OpenAIRE

    Hoff Dupont, Fabrício; Zaragoza Bertomeu, Jordi; Rech, Cassiano; Pinheiro, José Renes

    2015-01-01

    This paper presents a review and a comparative analysis between mathematical models for the efficiency of power converters. Two different types of models are considered, being one for converters subject solely for output power variations, and a second one also considering input voltage variations. Both cases are particularly important for systems fed by renewable sources as photovoltaic panels or wind turbines. Knowledge of the appropriate models is of interest in the dev...

  3. Resonant Wave Energy Converters: Concept development

    International Nuclear Information System (INIS)

    The Resonant Wave Energy Converter (REWEC) is a device for converting sea wave energy to electrical energy. It belongs to the family of Oscillating Water Columns and is composed by an absorbing chamber connected to the open sea via a vertical duct. The paper gives a holistic view on the concept development of the device, starting from its implementation in the context of submerged breakwaters to the recently developed vertical breakwaters.

  4. Switching power converters medium and high power

    CERN Document Server

    Neacsu, Dorin O

    2013-01-01

    An examination of all of the multidisciplinary aspects of medium- and high-power converter systems, including basic power electronics, digital control and hardware, sensors, analog preprocessing of signals, protection devices and fault management, and pulse-width-modulation (PWM) algorithms, Switching Power Converters: Medium and High Power, Second Edition discusses the actual use of industrial technology and its related subassemblies and components, covering facets of implementation otherwise overlooked by theoretical textbooks. The updated Second Edition contains many new figures, as well as

  5. Design of fission neutron converter in HFETR

    International Nuclear Information System (INIS)

    In order to increase local fast neutron fluence rate in High Flux Engineering Test Reactor (HFETR), the fission neutron converter adopted the crisscross fuel rod whose fuel pellet was made of high fission density alloy UMo with 7% Mo. 62 fuel rods in the converter were arranged with triangle dot-matrix between outer tube with diameter of 6.3 mm and inner tube with diameter of 24 mm. And the converter has an irradiation hole with diameter of 20 mm in the center. The calculation result with MCNP shows that fast neutron (E>1 MeV) fluence rate of irradiated samples in the converter can achieve up to 3.34 × 1014 cm-2·s-1, which is about 40% higher than that in the HFETR core at the same position without converter. On the other hand, under the condition of design flow velocity and pressure, the analysis results with ANSYS/CFX show that the maximum permission power can reach 2.4 MW and the maximum power density of fuel pellet is S. 007 kW/cm3. Here, the cladding temperature of the fuel rod is 193.6 ℃, and the converter can fulfill the requirement of thermal-hydraulic design criteria of HFETR and flow instability will not occur. (authors)

  6. LHC Power Converters: A Precision Game

    CERN Multimedia

    2001-01-01

    The LHC test-bed, String 2, is close to commissioning and one important element to get a first chance to prove what it can do is the power converter system. In String 2 there are 16 converters, in the full LHC there will be almost 1800. This article takes a look at what is so special about the power converters for the LHC. The 13 000 Amps power converters with the watercooled cables going to the String 2 feedboxes. The LHC's superconducting magnets will be the pinnacle of high technology. But to work, they'll need the help of high-precision power converters to supply them with extremely stable DC current. Perfection will be the name of the game, with an accuracy of just 1-2 parts per million (ppm) required. LEP, for the sake of comparison, could live with 10-20 ppm. The LHC's power converters will be very different from those of LEP or the SPS since the new accelerator's magnets are mostly superconducting. That means that they require much higher currents at a lower voltage since superconductors have no re...

  7. Performance and Analysis of Modular Multilevel Converter

    Directory of Open Access Journals (Sweden)

    T.Yuvaraja

    2016-07-01

    Full Text Available The Modular Multilevel Converter (MMC represents an emerging topology with a scalable technology making high voltage and power capability possible. The MMC is built up by identical, but individually controllable sub modules. The Modular Multilevel Converter (MMC is a new topology for multilevel converters with potential for medium voltage and high voltage applications. Equivalent Circuit models and dynamic models for the MMC that provide a faithful representation of system behavior are quite complex given the large number of energy states and control variables. They are not particularly useful in studying the terminal behavior of the converter and for the development of an intuitive control approach to regulate power transfer. A control scheme with a new sub module capacitor voltage balancing method is also proposed in this paper. Modular multilevel converters, based on cascading of half bridge converter cells, can combine low switching frequency with low harmonic interference. They can be designed for high operating voltages without direct series connection of semiconductor element

  8. Simulation of Multi output Fly back Converter with Integrated Auxiliary Buck Converter with reduced components

    Directory of Open Access Journals (Sweden)

    J.KOMATHI

    2015-04-01

    Full Text Available The fly back converter has been widely used for multi outputs due to the simple structure and low cost in low-power applications. This paper presents a new multi output converter. It consists of a half-bridge inverter with boost converter in primary side and a fly back rectifier that is integrated with an auxiliary buck converter in secondary side. The boost converter is used to generate high voltage dc from Low voltage PV cells. The primary switches control the main output voltage and the secondary synchronous switches control the auxiliary output voltage. The main advantages of the proposed converter are that the transformer size can be reduced due to the less magnetizing offset current, all the power switches including synchronous ones can achieve the zero-voltage switching (ZVS and it has no output cross regulation problems. The circuit is simulated using MATLAB. The performance is verified with simulation results.

  9. Dual Converter Fed Open-End Transformer Topology with Parallel Converters and Integrated Magnetics

    DEFF Research Database (Denmark)

    Gohil, Ghanshyamsinh Vijaysinh; Bede, Lorand; Teodorescu, Remus;

    2016-01-01

    converter group comprises of two parallel Voltage Source Converters (VSCs), whose carrier signals are interleaved to improve the harmonic quality of the resultant switched output voltage of that converter group. However, an additional inductive component is required to suppress the circulating current...... procedure is also described. The volume and the losses of the proposed solution are compared with that of the state-of-art solution. The control of the proposed converter system is also discussed. The analysis has been verified by the simulation and experimental results....

  10. A New Hard Switching Bidirectional Converter With High Power Density

    OpenAIRE

    Bahador Fani; Majid Delshad; Daryoosh Nazarpour

    2010-01-01

    In this paper, a new isolated dc-dc bidirectional converter is proposed. This converter consists of two transformers (flyback and forward) and only one switch in primary side and one switch in secondary side of transformers. In this converter energy transfers to the output in both on and off switch states so power density of this converter is high This converter controlled by PWM signal. Also this converter operates over a wide input voltage range. Theoretical analysis is presented and compu...

  11. A High-Affinity Adenosine Kinase from Anopheles Gambiae

    Energy Technology Data Exchange (ETDEWEB)

    M Cassera; M Ho; E Merino; E Burgos; A Rinaldo-Matthis; S Almo; V Schramm

    2011-12-31

    Genome analysis revealed a mosquito orthologue of adenosine kinase in Anopheles gambiae (AgAK; the most important vector for the transmission of Plasmodium falciparum in Africa). P. falciparum are purine auxotrophs and do not express an adenosine kinase but rely on their hosts for purines. AgAK was kinetically characterized and found to have the highest affinity for adenosine (K{sub m} = 8.1 nM) of any known adenosine kinase. AgAK is specific for adenosine at the nucleoside site, but several nucleotide triphosphate phosphoryl donors are tolerated. The AgAK crystal structure with a bound bisubstrate analogue Ap{sub 4}A (2.0 {angstrom} resolution) reveals interactions for adenosine and ATP and the geometry for phosphoryl transfer. The polyphosphate charge is partly neutralized by a bound Mg{sup 2+} ion and an ion pair to a catalytic site Arg. The AgAK structure consists of a large catalytic core in a three-layer {alpha}/{beta}/{alpha} sandwich, and a small cap domain in contact with adenosine. The specificity and tight binding for adenosine arise from hydrogen bond interactions of Asn14, Leu16, Leu40, Leu133, Leu168, Phe168, and Thr171 and the backbone of Ile39 and Phe168 with the adenine ring as well as through hydrogen bond interactions between Asp18, Gly64, and Asn68 and the ribosyl 2'- and 3'-hydroxyl groups. The structure is more similar to that of human adenosine kinase (48% identical) than to that of AK from Toxoplasma gondii (31% identical). With this extraordinary affinity for AgAK, adenosine is efficiently captured and converted to AMP at near the diffusion limit, suggesting an important role for this enzyme in the maintenance of the adenine nucleotide pool. mRNA analysis verifies that AgAK transcripts are produced in the adult insects.

  12. Protein kinase CK2 in human diseases

    DEFF Research Database (Denmark)

    Guerra, Barbara; Issinger, Olaf-Georg

    2008-01-01

    Protein kinase CK2 (formerly referred to as casein kinase II) is an evolutionary conserved, ubiquitous protein kinase. There are two paralog catalytic subunits, i.e. alpha (A1) and alpha' (A2). The alpha and alpha' subunits are linked to two beta subunits to produce a heterotetrameric structure....... The catalytic alpha subunits are distantly related to the CMGC subfamily of kinases, such as the Cdk kinases. There are some peculiarities associated with protein kinase CK2, which are not found with most other protein kinases: (i) the enzyme is constitutively active, (ii) it can use ATP and GTP and...... specifically target this protein kinase [10]. Since not all the aspects of what has been published on CK2 can be covered in this review, we would like to recommend the following reviews; (i) for general information on CK2 [11-18] and (ii) with a focus on aberrant CK2 [19-22]....

  13. Renal targeting of kinase inhibitors

    NARCIS (Netherlands)

    Dolman, M. E. M.; Fretz, M. M.; Segers, Gj. W.; Lacombe, M.; Prakash, J.; Storm, G.; Hennink, W. E.; Kok, R. J.

    2008-01-01

    Activation of proximal tubular cells by fibrotic and inflammatory mediators is an important hallmark of chronic kidney disease. We have developed a novel strategy to intervene in renal fibrosis, by means of locally delivered kinase inhibitors. Such compounds will display enhanced activity within tub

  14. Inhibitors of protein kinase C

    Institute of Scientific and Technical Information of China (English)

    LIU Shiying; JIANG Yuyang; CAO Jian; LIU Feng; MA Li; ZHAO Yufen

    2005-01-01

    Protein kinase catalyzes the transfer of the γ-phosphoryl group from ATP to the hydroxyl groups of protein side chains, which plays critical roles in signal transduction pathways by transmitting extracellular signals across the plasma membrane and nuclear membrane to the destination sites in the cytoplasm and the nucleus. Protein kinase C (PKC) is a superfamily of phospholipid-dependent Ser/Thr kinase. There are at least 12 isozymes in PKC family. They are distributed in different tissues and play different roles in physiological processes. On account of their concern with a variety of pathophysiologic states, such as cancer, inflammatory conditions, autoimmune disorder, and cardiac diseases, the inhibitors, which can inhibit the activity of PKC and the interaction of cytokine with receptor, and interfere signal transduction pathway, may be candidates of therapeutic drugs. Therefore, intense efforts have been made to develop specific protein kinase inhibitors as biological tools and therapeutic agents. This article reviews the recent development of some of PKC inhibitors based on their interaction with different conserved domains and different inhibition mechanisms.

  15. Degradation of Activated Protein Kinases by Ubiquitination

    OpenAIRE

    Lu, Zhimin; Hunter, Tony

    2009-01-01

    Protein kinases are important regulators of intracellular signal transduction pathways and play critical roles in diverse cellular functions. Once a protein kinase is activated, its activity is subsequently downregulated through a variety of mechanisms. Accumulating evidence indicates that the activation of protein kinases commonly initiates their downregulation via the ubiquitin/proteasome pathway. Failure to regulate protein kinase activity or expression levels can cause human diseases.

  16. Determinants of homodimerization specificity in histidine kinases

    OpenAIRE

    Ashenberg, Orr; Rozen-Gagnon, Kathryn; Laub, Michael T; Keating, Amy E.

    2011-01-01

    Two-component signal transduction pathways consisting of a histidine kinase and a response regulator are used by prokaryotes to respond to diverse environmental and intracellular stimuli. Most species encode numerous paralogous histidine kinases that exhibit significant structural similarity. Yet in almost all known examples, histidine kinases are thought to function as homodimers. We investigated the molecular basis of dimerization specificity, focusing on the model histidine kinase EnvZ and...

  17. Efficiency of Thermionic and Thermoelectric Converters

    Science.gov (United States)

    Gerstenmaier, York Christian; Wachutka, Gerhard

    2007-02-01

    Thermoelectric and thermionic converters — also in micro- and nano-meter design — are considered for power generation and cooling applications. The potential of thermionic vacuum gap converters is investigated precisely by a new advanced theory with inclusion of backward currents from the 2nd electrode, losses due to thermal radiation and ohmic resistance in the electrodes, tunneling through the gap, image forces, and space charge effects. The efficiency of nano-meter gap thermionic converters is by far higher than for thermoelectric devices (including nano-structured superlattices) for operating temperatures above 800°K, however, there is no chance of realization with today's technology. For a vacuum gap width of about 1 μm the performance is higher than for hypothetical bulk- thermoelectric generators (TEGs) with ZT = 1 for T > 1000°K and also higher than for hypothetical nano-structured superlattices (ZT = 2.4) for T > 1200°K. A thermionic converter with gap width of 5μm has lower performance than a TEG with ZT = 1, however, also operates at T > 1200°K. Reasonable performance of thermionic converters at T ⩽ 500°K necessitates materials with workfunctions ⩽ 0.5 eV.

  18. Ac-dc converter firing error detection

    International Nuclear Information System (INIS)

    Each of the twelve Booster Main Magnet Power Supply modules consist of two three-phase, full-wave rectifier bridges in series to provide a 560 VDC maximum output. The harmonic contents of the twelve-pulse ac-dc converter output are multiples of the 60 Hz ac power input, with a predominant 720 Hz signal greater than 14 dB in magnitude above the closest harmonic components at maximum output. The 720 Hz harmonic is typically greater than 20 dB below the 500 VDC output signal under normal operation. Extracting specific harmonics from the rectifier output signal of a 6, 12, or 24 pulse ac-dc converter allows the detection of SCR firing angle errors or complete misfires. A bandpass filter provides the input signal to a frequency-to-voltage converter. Comparing the output of the frequency-to-voltage converter to a reference voltage level provides an indication of the magnitude of the harmonics in the ac-dc converter output signal

  19. Synchronous Control of Modular Multilevel Converters

    DEFF Research Database (Denmark)

    Oleschuk, Valentin; Blaabjerg, Frede; Bose, Bimal K.

    2002-01-01

    A novel method of direct synchronous pulsewidth modulation (PWM) is applied for control of modular multilevel converters consisting from three standard triphase inverter modules along with an 0.33 p.u. output transformer. The proposed method provides synchronisation of the voltage waveforms...... for determination of the pulse patterns, have been analysed and compared using simulations of the systems with low switching frequencies, which normally are used in high power systems....... for each module and the composed voltage at the output of the converter. Multilevel output voltage of the converter has quarter-wave symmetry during the whole range including the zone of overmodulation. Both continuous and discontinuous versions of synchronous PWM, based on vector approach...

  20. Metamaterial polarization converter analysis: limits of performance

    DEFF Research Database (Denmark)

    Markovich, Dmitry L.; Andryieuski, Andrei; Zalkovskij, Maksim;

    2013-01-01

    In this paper, we analyze the theoretical limits of a metamaterial-based converter with orthogonal linear eigenpolarizations that allow linear-to-elliptical polarization transformation with any desired ellipticity and ellipse orientation. We employ the transmission line approach providing a needed...... level of the design generalization. Our analysis reveals that the maximal conversion efficiency for transmission through a single metamaterial layer is 50 %, while the realistic reflection configuration can give the conversion efficiency up to 90 %. We show that a double layer transmission converter...... and a single layer with a ground plane can have 100 % polarization conversion efficiency. We tested our conclusions numerically reaching the designated limits of efficiency using a simple metamaterial design. Our general analysis provides useful guidelines for the metamaterial polarization converter design...

  1. SIG Galileo final converter technical summary report

    International Nuclear Information System (INIS)

    The report is primarily concerned with the work performed for DOE on converter development and fabrication for the NASA Galileo Jupiter mission as a DOE prime contractor with interface primarily with Teledyne Energy Systems. The activities reported on were directed toward design, analysis and testing of modules and converters SN-1 thru SN-7 and attendant Quality Control and Reliability effort. Although assembly and testing of SN-1 was not accomplished due to the stop work order, the design was virtually completed and a significant amount of subcontracting and manufacturing of both module and converter components was underway. These subcontracting and manufacturing activities were selectively closed down depending upon degree of completion and material or hardware potential usage in the Technology Program

  2. Power system applications for PASC converter systems

    Energy Technology Data Exchange (ETDEWEB)

    Donnelly, M.K. [Pacific Northwest Lab., Richland, WA (United States); Johnson, R.M. [Montana State Univ., Bozeman, MT (United States)

    1994-04-01

    This paper shows, using computer EMTP simulations, some preliminary results of applying pulse amplitude synthesis and control (PASC) technology to single-source level voltage converter system. The method can be applied to any single terminal pair source with appropriate modifications in power extraction interface and computer control program to match source and load impedance characteristics. The PASC realization as discussed here employs banks of transformers, one bank per phase, in which the primaries are connected in parallel through a switch matrix to the dc source. Two opposite polarity primaries per transformer are pulsed alternatively in time to produce an oscillatory sinusoidal output waveform. PASC conversion system capabilities to produce both leading and lagging power factor power output in single-phase and three-phase {Delta} or Y configurations are illustrated. EMTP simulations are used to demonstrate the converter capabilities. Also included are discussions regarding harmonics and potential control strategies to adapt the converter to an application or to minimize harmonics.

  3. Self-oscillating resonant power converter

    DEFF Research Database (Denmark)

    2014-01-01

    The present invention relates to resonant power converters and inverters comprising a self-oscillating feedback loop coupled from a switch output to a control input of a switching network comprising one or more semiconductor switches. The self-oscillating feedback loop sets a switching frequency...... of the power converter and comprises a first intrinsic switch capacitance coupled between a switch output and a control input of the switching network and a first inductor. The first inductor is coupled in-between a first bias voltage source and the control input of the switching network and has...... a substantially fixed inductance. The first bias voltage source is configured to generate an adjustable bias voltage applied to the first inductor. The output voltage of the power converter is controlled in a flexible and rapid manner by controlling the adjustable bias voltage....

  4. CMOS Integrated Capacitive DC-DC Converters

    CERN Document Server

    Van Breussegem, Tom

    2013-01-01

    This book provides a detailed analysis of all aspects of capacitive DC-DC converter design: topology selection, control loop design and noise mitigation. Readers will benefit from the authors’ systematic overview that starts from the ground up, in-depth circuit analysis and a thorough review of recently proposed techniques and design methodologies.  Not only design techniques are discussed, but also implementation in CMOS is shown, by pinpointing the technological opportunities of CMOS and demonstrating the implementation based on four state-of-the-art prototypes.  Provides a detailed analysis of all aspects of capacitive DC-DC converter design;  Analyzes the potential of this type of DC-DC converter and introduces a number of techniques to unleash their full potential; Combines system theory with practical implementation techniques; Includes unique analysis of CMOS technology for this application; Provides in-depth analysis of four fabricated prototypes.

  5. Single phase AC-DC power factor corrected converter with high frequency isolation using buck converter

    Directory of Open Access Journals (Sweden)

    R. Ramesh,

    2014-03-01

    Full Text Available Single phase ac-dc converters having high frequency isolation are implemented in buck, boost, buck-boost configuration with improving the power quality in terms of reducing the harmonics of input current. The paperpropose the circuit configuration, control mechanism, and simulation result for the single phase ac-dc converter.

  6. Efficient polarization converter for projection displays.

    Science.gov (United States)

    Yip, W C; Huang, H C; Kwok, H S

    1997-09-01

    In the waveguiding limit, a twisted nematic liquid crystal cell behaves as an achromatic polarization rotator. We propose and demonstrate the application of such a polarization rotator to convert unpolarized light into linearly polarized light with almost 100% efficiency. This polarization converter has a 2:1 aspect ratio, which is close to the 16:9 ratio for modern televisions. It can be used therefore in a projection display with polarization-dependent light valves such as a liquid crystal light valve. Both transmittive and reflective light valves can be used. The temperature dependence of the achromatic polarization rotator is also studied. PMID:18259503

  7. A linear temperature-to-frequency converter

    DEFF Research Database (Denmark)

    Løvborg, Leif

    1965-01-01

    , and that the maximum value of the temperature-frequency coefficient beta in this point is-1/3 alpha, where a is the temperature coefficient of the thermistor at the corresponding temperature. Curves showing the range in which the converter is expected to be linear to within plusmn0.1 degC are given. A laboratory......-built converter having beta = 1.0% degC-1 at 25degC is found to be linear to within plusmn0. 1 degC from 10 to 40degC....

  8. Electrodes For Alkali-Metal Thermoelectric Converters

    Science.gov (United States)

    Williams, Roger M.; Wheeler, Bob L.; Jeffries-Nakamura, Barbara; Lamb, James L.; Bankston, C. Perry; Cole, Terry

    1989-01-01

    Combination of thin, porous electrode and overlying collector grid reduces internal resistance of alkali-metal thermoelectric converter cell. Low resistance of new electrode and grid boosts power density nearly to 1 W/cm2 of electrode area at typical operating temperatures of 1,000 to 1,300 K. Conductive grid encircles electrode film on alumina tube. Bus wire runs along tube to collect electrical current from grid. Such converters used to transform solar, nuclear, and waste heat into electric power.

  9. Solar energy converter using surface plasma waves

    Science.gov (United States)

    Anderson, L. M. (Inventor)

    1984-01-01

    Sunlight is dispersed over a diffraction grating formed on the surface of a conducting film on a substrate. The angular dispersion controls the effective grating period so that a matching spectrum of surface plasmons is excited for parallel processing on the conducting film. The resulting surface plasmons carry energy to an array of inelastic tunnel diodes. This solar energy converter does not require different materials for each frequency band, and sunlight is directly converted to electricity in an efficient manner by extracting more energy from the more energetic photons.

  10. Efficient modelling of a modular multilevel converter

    DEFF Research Database (Denmark)

    El-Khatib, Walid Ziad; Holbøll, Joachim; Rasmussen, Tonny Wederberg

    2013-01-01

    Looking at the near future, we see that offshore wind penetration into the electrical grid will continue increasing rapidly. Until very recently, the trend has been to place the offshore wind farms close to shore within the reach for transmission using HVAC cables but for larger distances HVDC...... calculated for the converter. Time-domain simulations on a MMC HVDC test system are performed in the PSCAD/EMTDC software environment based on the new model. The results demonstrate that the modeled MMC-HVDC system with or without converter transformer is able to operate under specific fault conditions....

  11. Is China Ready for Full Yuan Convertibility?

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Although China has made headway in reforming the exchange rate regime of its currency,the yuan,and expanding the use of it in cross-border trade during the past year,the yuan is far from fully convertible.Huang Yiping,a professor at the National School of Development of Peking University,said in an article for Beijing Review that China has the conditions for capital account liberalization and should strive for basic convertibility within five years. Edited excerpts follow

  12. All linear optical devices are mode converters

    OpenAIRE

    Miller, David A. B.

    2012-01-01

    We show that every linear optical component can be completely described as a device that converts one set of orthogonal input modes, one by one, to a matching set of orthogonal output modes. This result holds for any linear optical structure with any specific variation in space and/or time of its structure. There are therefore preferred orthogonal "mode converter" basis sets of input and output functions for describing any linear optical device, in terms of which the device can be described b...

  13. Combination solar photovoltaic heat engine energy converter

    Science.gov (United States)

    Chubb, Donald L.

    1987-01-01

    A combination solar photovoltaic heat engine converter is proposed. Such a system is suitable for either terrestrial or space power applications. The combination system has a higher efficiency than either the photovoltaic array or the heat engine alone can attain. Advantages in concentrator and radiator area and receiver mass of the photovoltaic heat engine system over a heat-engine-only system are estimated. A mass and area comparison between the proposed space station organic Rankine power system and a combination PV-heat engine system is made. The critical problem for the proposed converter is the necessity for high temperature photovoltaic array operation. Estimates of the required photovoltaic temperature are presented.

  14. Faults and Diagnosis Systems in Power Converters

    DEFF Research Database (Denmark)

    Lee, Kyo-Beum; Choi, Uimin

    2014-01-01

    A power converter is needed in almost all kinds of renewable energy systems and drive systems. It is used both for controlling the renewable source and for interfacing with the load, which can be grid-connected or working in standalone mode. Further, it drives the motors efficiently. Increasing...... efforts have been put into making these systems better in terms of reliability in order to achieve high power source availability, reduce the cost of energy and also increase the reliability of overall systems. Among the components used in power converters, a power device and a capacitor fault occurs most...

  15. DMPD: Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling? [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15081522 Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signall...ruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling? PubmedID 15081522 Title Bruton...'s tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling? Authors

  16. Bidirectional converter interface for a battery energy storage test bench

    DEFF Research Database (Denmark)

    Trintis, Ionut; Thomas, Stephan; Blank, Tobias;

    2011-01-01

    This paper presents the bidirectional converter interface for a 6 kV battery energy storage test bench. The power electronic interface consists a two stage converter topology having a low voltage dc-ac grid connected converter and a new dual active bridge dc-dc converter with high transformation...

  17. Endocytosis of Receptor Tyrosine Kinases

    Science.gov (United States)

    Goh, Lai Kuan

    2013-01-01

    Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The canonical model of RTK endocytosis involves rapid internalization of an RTK activated by ligand binding at the cell surface and subsequent sorting of internalized ligand-RTK complexes to lysosomes for degradation. Activation of the intrinsic tyrosine kinase activity of RTKs results in autophosphorylation, which is mechanistically coupled to the recruitment of adaptor proteins and conjugation of ubiquitin to RTKs. Ubiquitination serves to mediate interactions of RTKs with sorting machineries both at the cell surface and on endosomes. The pathways and kinetics of RTK endocytic trafficking, molecular mechanisms underlying sorting processes, and examples of deviations from the standard trafficking itinerary in the RTK family are discussed in this work. PMID:23637288

  18. Integrated multilevel converter and battery management

    OpenAIRE

    K. Wilkie; Stone, D.; Bingham, C.; Foster, M.

    2008-01-01

    A cascaded H-bridge multilevel converter is proposed as a BLDC drive incorporating real-time battery management. Intelligent H-bridges are used to monitor battery cells whilst simultaneously increasing their performance by reducing the variation between cells and controlling their discharge profiles.

  19. Angiotensin converting enzyme inhibitor induced hyperkalaemic paralysis

    OpenAIRE

    Dutta., D; Fischler, M; McClung, A

    2001-01-01

    Secondary hyperkalaemic paralysis is a rare condition often mimicking the Guillain-Barré syndrome. There have been a few case reports of hyperkalaemia caused by renal failure, trauma, and drugs where the presentation has been with muscle weakness. A case of hyperkalaemic paralysis caused by an angiotensin converting enzyme inhibitor is reported.


Keywords: hyperkalaemia; paralysis; ACE inhibitors

  20. China to Gradually Make Capital Account Convertible

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ China is pushing forward its currency Renminbi (RMB)'s capital account convertibility gradually and in a stable manner, said an official with the State Administration of Foreign Exchange (SAFE), ruling out both an adventurous leap and conservative cautiousness, according to a report of Xinhua on April 12.

  1. China to Gradually Make Capital Account Convertible

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

      China is pushing forward its currency Renminbi (RMB)'s capital account convertibility gradually and in a stable manner, said an official with the State Administration of Foreign Exchange (SAFE), ruling out both an adventurous leap and conservative cautiousness, according to a report of Xinhua on April 12.……

  2. Online Scheduling in Distributed Message Converter Systems

    NARCIS (Netherlands)

    Risse, Thomas; Wombacher, Andreas; Surridge, Mike; Taylor, Steve; Aberer, Karl

    2001-01-01

    The optimal distribution of jobs among hosts in distributed environments is an important factor to achieve high performance. The optimal strategy depends on the application. In this paper we present a new online scheduling strategy for distributed EDI converter system. The strategy is based on the B

  3. Impedance interactions in bidirectional cascaded converter

    DEFF Research Database (Denmark)

    Tian, Yanjun; Loh, Poh Chiang; Chen, Zhe;

    2016-01-01

    here for showing that forward and reverse interactions are prominently different in terms of dynamics and stability, even though the cascaded converter control remains unchanged. The concluded findings have been verified by simulation and experimental results, from which, important guidelines have been...

  4. Catalytic Converters Maintain Air Quality in Mines

    Science.gov (United States)

    2014-01-01

    At Langley Research Center, engineers developed a tin-oxide based washcoat to prevent oxygen buildup in carbon dioxide lasers used to detect wind shears. Airflow Catalyst Systems Inc. of Rochester, New York, licensed the technology and then adapted the washcoat for use as a catalytic converter to treat the exhaust from diesel mining equipment.

  5. Power electronics converters for wind turbine systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Liserre, Marco; Ma, Ke

    2011-01-01

    The steady growth of installed wind power which reached 200 GW capacity in 2010, together with the up-scaling of the single wind turbine power capability - 7 MW’s has been announced by manufacturers - has pushed the research and development of power converters towards full scale power conversion,...

  6. Power Electronics Converters for Wind Turbine Systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Liserre, Marco; Ma, Ke

    2012-01-01

    The steady growth of installed wind power together with the upscaling of the single wind turbine power capability has pushed the research and development of power converters toward full-scale power conversion, lowered cost pr kW, increased power density, and also the need for higher reliability. ...

  7. Generalized modular multilevel converter and modulation

    DEFF Research Database (Denmark)

    Liu, Hui; Loh, Poh Chiang; Blaabjerg, Frede

    2014-01-01

    Modular multilevel converter (MMC) has gained popularity recently with its modulation, capacitor voltage balancing and circulating current issues widely discussed. Contributing to this effort, a study is presented here to show how the MMC topology can be derived from the viewpoint of two series c...

  8. Performance Evaluation of Wave Energy Converters

    DEFF Research Database (Denmark)

    Pecher, Arthur

    stages, and results thereby in a need for specific test objectives and procedures for each development stage. This PhD thesis has looked into the different development stages and more specifically in the performance assessment of wave energy converters based on tank testing and sea trials. The objective...

  9. Performance Evaluation of Wave Energy Converters

    DEFF Research Database (Denmark)

    Pecher, Arthur

    stages, and results thereby in a need for specific testobjectives and procedures for each development stage. This PhD thesis has looked into the different development stages and more specifically in the performance assessment of wave energy converters based on tank testing and sea trials. The objective...

  10. Efficient, lightweight dc/dc switching converter

    Science.gov (United States)

    Cuk, S.; Middlebrook, R. D.

    1981-01-01

    Converters have input properties of boost power stage and output properties of buck power stage, yet they perform general conversion function with high efficiency. Other features include non-pulsating input/output currents, use of capacitive energy transfer, low output voltage ripple, reduced EMI, and small size.

  11. Convertible bonds and bank risk-taking

    NARCIS (Netherlands)

    N. Martynova; E. Perotti

    2015-01-01

    We study how contingent capital that converts in equity ahead of default affects bankrisk-shifting. Going concern conversion restores equity value in highly levered states,thus reducing heightened risk incentives. In contrast, conversion at default for traditionalbail-inable debt has no effect on en

  12. Mathematical modeling of the flash converting process

    Energy Technology Data Exchange (ETDEWEB)

    Sohn, H.Y.; Perez-Tello, M.; Riihilahti, K.M. [Utah Univ., Salt Lake City, UT (United States)

    1996-12-31

    An axisymmetric mathematical model for the Kennecott-Outokumpu flash converting process for converting solid copper matte to copper is presented. The model is an adaptation of the comprehensive mathematical model formerly developed at the University of Utah for the flash smelting of copper concentrates. The model incorporates the transport of momentum, heat, mass, and reaction kinetics between gas and particles in a particle-laden turbulent gas jet. The standard k-{epsilon} model is used to describe gas-phase turbulence in an Eulerian framework. The particle-phase is treated from a Lagrangian viewpoint which is coupled to the gas-phase via the source terms in the Eulerian gas-phase governing equations. Matte particles were represented as Cu{sub 2}S yFeS, and assumed to undergo homogeneous oxidation to Cu{sub 2}O, Fe{sub 3}O{sub 4}, and SO{sub 2}. A reaction kinetics mechanism involving both external mass transfer of oxygen gas to the particle surface and diffusion of oxygen through the porous oxide layer is proposed to estimate the particle oxidation rate Predictions of the mathematical model were compared with the experimental data collected in a bench-scale flash converting facility. Good agreement between the model predictions and the measurements was obtained. The model was used to study the effect of different gas-injection configurations on the overall fluid dynamics in a commercial size flash converting shaft. (author)

  13. Converting Student Support Services to Online Delivery.

    Science.gov (United States)

    Brigham, David E.

    2001-01-01

    Uses a systems framework to analyze the creation of student support services for distance education at Regents College: electronic advising, electronic peer network, online course database, online bookstore, virtual library, and alumni services website. Addresses the issues involved in converting distance education programs from print-based and…

  14. Hybrid switch for resonant power converters

    Science.gov (United States)

    Lai, Jih-Sheng; Yu, Wensong

    2014-09-09

    A hybrid switch comprising two semiconductor switches connected in parallel but having different voltage drop characteristics as a function of current facilitates attainment of zero voltage switching and reduces conduction losses to complement reduction of switching losses achieved through zero voltage switching in power converters such as high-current inverters.

  15. Development of the Wave Energy Converter

    DEFF Research Database (Denmark)

    Kofoed, Jens Peter; Frigaard, Peter; Sørensen, Hans Christian;

    2000-01-01

    The development of the wave energy converter Wave Dragon (WD) is presented. The WD is based on the overtopping principle. Initially a description of the WD is given. Then the development over time in terms of the various research and development projects working with the concept is described...

  16. Aquabuoy Wave Energy Converter

    DEFF Research Database (Denmark)

    Vicinanza, Diego; Margheritini, Lucia; Frigaard, Peter

    The work reported here is part of the contract agreement between the Finavera Renewables Ocean Energy Ltd. and the Department of Civil Engineering Hydraulics and Coastal Engineering Laboratory to instrument a model in scale 1:10 to prototype of the AquaBuOY (AB) wave energy converter and to analyse...

  17. RIP Kinases Initiate Programmed Necrosis

    Institute of Scientific and Technical Information of China (English)

    Lorenzo Galluzzi; Oliver Kepp; Guido Kroemer

    2009-01-01

    Some lethal stimuli can induce either apoptosis or necrosis, depending on the cell type and/or experimental setting. Until recently,the molecular bases of this phenomenon were largely unknown. Now, two members of the receptor-interacting serine-threonine kinase (RIP) family, RIP1 and RIP3, have been demonstrated to control the switch between apoptotic and necrotic cell death.Some mechanistic details, however, remain controversial.

  18. Thymidine kinase diversity in bacteria

    DEFF Research Database (Denmark)

    Sandrini, Michael; Clausen, A.R.; Munch-Petersen, B.;

    2006-01-01

    Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The....... The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria....

  19. Pantothenate Kinase-Associated Neurodegeneration

    OpenAIRE

    Meitinger, Thomas; Prokisch, Holger; Hartig, Monika B.; Klopstock, Thomas

    2012-01-01

    Pantothenate kinase-associated neurodegeneration (PKAN) is a hereditary progressive disorder and the most frequent form of neurodegeneration with brain iron accumulation (NBIA). PKAN patients present with a progressive movement disorder, dysarthria, cognitive impairment and retinitis pigmentosa. In magnetic resonance imaging, PKAN patients exhibit the pathognonomic "eye of the tiger" sign in the globus pallidus which corresponds to iron accumulation and gliosis as shown in neuropathological e...

  20. Regulation and function of TPL-2,an IκB kinase-regulated MAP kinase kinase kinase

    Institute of Scientific and Technical Information of China (English)

    Thorsten Gantke; Srividya Sriskantharajah; Steven C Ley

    2011-01-01

    The IκB kinase(IKK)complex plays a well-documented role in innate and adaptive immunity.This function has been widely attributed to its role as the central activator of the NF-κB family of transcription factors.However,another important consequence of IKK activation is the regulation of TPL-2,a MEK kinase that is required for activation of ERK-1/2 MAP kinases in myeioid cells following Toll-like receptor and TNF receptor stimulation.In unstimulated cells,TPL-2 is stoichiometrically complexed with the NF-κB inhibitory protein NF-κB1 p105,which blocks TPL-2 access to its substrate MEK,and the ubiquitin-binding protein ABIN-2(A20-binding inhibitor of NF-κB 2),both of which are required to maintain TPL-2 protein stability.Following agonist stimulation,the IKK complex phosphorylates p105,triggering its K48-1inked ubiquitination and degradation by the proteasome.This releases TPL-2 from p105-mediated inhibition,facilitating activation of MEK,in addition to modulating NF-κB activation by liberating associated Rel subunits for translocation into the nucleus.IKK-induced proteolysis of 0105,therefore,can directly regulate both NF-κB and ERK MAP kinase activation via NF-κB1 p105.TPL-2 is critical for production of the proinflammatory cytokine TNF during inflammatory responses.Consequently,there has been considerable interest in the pharmaceutical industry to develop selective TPL-2 inhibitors as drugs for the treatment of TNF-dependent inflammatory,diseases,such as rheumatoid arthritis and inflammatory bowel disease.This review summarizes our current understanding of the regulation of TPL-2 signaling function,and also the complex positive and negative roles of TPL-2 in immune and inflammatory responses.

  1. A New Hard Switching Bidirectional Converter With High Power Density

    Directory of Open Access Journals (Sweden)

    Bahador Fani

    2010-01-01

    Full Text Available In this paper, a new isolated dc-dc bidirectional converter is proposed. This converter consists of two transformers (flyback and forward and only one switch in primary side and one switch in secondary side of transformers. In this converter energy transfers to the output in both on and off switch states so power density of this converter is high This converter controlled by PWM signal. Also this converter operates over a wide input voltage range. Theoretical analysis is presented and computer simulation and experimental results verify the converter analysis.

  2. A proteomic approach for comprehensively screening substrates of protein kinases such as Rho-kinase.

    Directory of Open Access Journals (Sweden)

    Mutsuki Amano

    Full Text Available BACKGROUND: Protein kinases are major components of signal transduction pathways in multiple cellular processes. Kinases directly interact with and phosphorylate downstream substrates, thus modulating their functions. Despite the importance of identifying substrates in order to more fully understand the signaling network of respective kinases, efficient methods to search for substrates remain poorly explored. METHODOLOGY/PRINCIPAL FINDINGS: We combined mass spectrometry and affinity column chromatography of the catalytic domain of protein kinases to screen potential substrates. Using the active catalytic fragment of Rho-kinase/ROCK/ROK as the model bait, we obtained about 300 interacting proteins from the rat brain cytosol fraction, which included the proteins previously reported as Rho-kinase substrates. Several novel interacting proteins, including doublecortin, were phosphorylated by Rho-kinase both in vitro and in vivo. CONCLUSIONS/SIGNIFICANCE: This method would enable identification of novel specific substrates for kinases such as Rho-kinase with high sensitivity.

  3. A low-voltage boost converter using a forward converter with integrated Meissner oscillator

    International Nuclear Information System (INIS)

    This paper describes a novel boost converter to be used with energy harvesters that provide only low output voltages. The device is self-supplied from electric power delivered to its input. With peak power conversion efficiencies above 30% at start-up voltages down to 10 mV this circuit sets best values in comparison with the state-of-the-art. This is achieved by the novel combination of a Meissner oscillator, used as stand-alone in most low-voltage step-up converters today, with a forward converter usually applied in high power systems

  4. Multi-output DC-DC converters based on diode-clamped converters configuration

    DEFF Research Database (Denmark)

    Nami, A.; Zare, F.; Ghosh, A.;

    2010-01-01

    for a diode-clamed inverter in the grid connection systems, where boosting low rectified output-voltage and series DC link capacitors is required. To verify the proposed topology, steady-state and dynamic analyses of a MOB converter are examined. A simple control strategy has been proposed to demonstrate...... the performance of the proposed topology for a double-output boost converter. The topology and its control strategy can easily be extended to offer multiple outputs. Simulation and experimental results are presented to show the validity of the control strategy for the proposed converter....

  5. A low-voltage boost converter using a forward converter with integrated Meissner oscillator

    Science.gov (United States)

    Woias, P.; Islam, M.; Heller, S.; Roth, R.

    2013-12-01

    This paper describes a novel boost converter to be used with energy harvesters that provide only low output voltages. The device is self-supplied from electric power delivered to its input. With peak power conversion efficiencies above 30% at start-up voltages down to 10 mV this circuit sets best values in comparison with the state-of-the-art. This is achieved by the novel combination of a Meissner oscillator, used as stand-alone in most low-voltage step-up converters today, with a forward converter usually applied in high power systems.

  6. Research on Converter Valve Overvoltage Mechanism and Calculation Conditions of ± 800 kV Converter Station

    Institute of Scientific and Technical Information of China (English)

    WANG Dongju; DENG Xu; ZHOU Hao; CHEN Xilei; XU Anwen; SHEN Yang

    2012-01-01

    The thyristor converter valve is the key equipment of commutation in ultra high voltage direct current (UHVDC) transmission systems. Owing to the limited voltage and current overload capacity, any transient overvoltage may cause permanent damage to the thyristor converter valve. In order to specify the converter valves' overvoltage levels of the ±800 kV UHVDC transmission system, the mechanisms of its generation and development are discussed in detail, from which the calculation conditions for the highest stresses of the converter valves are given. Finally, the converter valve's overvoltage of Xiluodu UHV converter station is simulated. The research results show that the overvoltages of the converter valves in the upper 3-pulse group of the high voltage(HV) and low voltage(LV) 12-pulse converter are generated jointly by the DC line voltage and the converter transformer's voltage at its valve side. Calculation conditions for this overvoltage are: DC system in bipolar operation mode, converter station operating as rectifier, maximum DC system operating voltage, minimum DC current, minimum AC system voltage of the converter station. Furthermore, the other converter valves' overvoltage is caused by the phase-to-phase switching surge generated at the converter station's AC side, penetrating into the valve hall. Overall, the maximum overvoltages of Xiluodu converter station in the upper 3-pulse group of the HV and LV 12-pulse converter are 379.1 kV and 384.9 kV, for other converter valves the maximum overvoltage is 375.3 kV.

  7. Imbalance between pulmonary angiotensin-converting enzyme and angiotensin-converting enzyme 2 activity in acute respiratory distress syndrome

    NARCIS (Netherlands)

    Wosten-van Asperen, Roelie M.; Bos, Albert; Bem, Reinout A.; Dierdorp, Barbara S.; Dekker, Tamara; van Goor, Harry; Kamilic, Jelena; van der Loos, Chris M.; van den Berg, Elske; Bruijn, Martijn; van Woensel, Job B.; Lutter, Rene

    2013-01-01

    Objective: Angiotensin-converting enzyme and its effector peptide angiotensin II have been implicated in the pathogenesis of acute respiratory distress syndrome. Recently, angiotensin-converting enzyme 2 was identified as the counter-regulatory enzyme of angiotensin-converting enzyme that converts a

  8. Efficient Wide Range Converters (EWiRaC): A new family of high efficient AC-DC Converters

    DEFF Research Database (Denmark)

    Petersen, Lars; Andersen, Michael Andreas E.

    2006-01-01

    The performance in terms of efficiency of the existing power supplies used for PFC is very dependent on the input voltage range. The boost converter is the most commonly used PFC converter because of its simplicity and high efficiency. But, the boost converter as well as other known converters...... the converter topology according to the input voltage. This new converter type has been named: efficient wide range converter (EWiRaC). The performance of the EWiRaC is experimental verified in a universal input range (90-270VAC) application with an output voltage of 185VDC capable of 500W output power. The EWi...

  9. TiConverter: A training image converting tool for multiple-point geostatistics

    Science.gov (United States)

    Fadlelmula F., Mohamed M.; Killough, John; Fraim, Michael

    2016-11-01

    TiConverter is a tool developed to ease the application of multiple-point geostatistics whether by the open source Stanford Geostatistical Modeling Software (SGeMS) or other available commercial software. TiConverter has a user-friendly interface and it allows the conversion of 2D training images into numerical representations in four different file formats without the need for additional code writing. These are the ASCII (.txt), the geostatistical software library (GSLIB) (.txt), the Isatis (.dat), and the VTK formats. It performs the conversion based on the RGB color system. In addition, TiConverter offers several useful tools including image resizing, smoothing, and segmenting tools. The purpose of this study is to introduce the TiConverter, and to demonstrate its application and advantages with several examples from the literature.

  10. Analog-digital converters for industrial applications including an introduction to digital-analog converters

    CERN Document Server

    Ohnhäuser, Frank

    2015-01-01

    This book offers students and those new to the topic of analog-to-digital converters (ADCs) a broad introduction, before going into details of the state-of-the-art design techniques for SAR and DS converters, including the latest research topics, which are valuable for IC design engineers as well as users of ADCs in applications. The book then addresses important topics, such as correct connectivity of ADCs in an application, the verification, characterization and testing of ADCs that ensure high-quality end products. Analog-to-digital converters are the central element in any data processing system and regulation loops such as modems or electrical motor drives. They significantly affect the performance and resolution of a system or end product. System development engineers need to be familiar with the performance parameters of the converters and understand the advantages and disadvantages of the various architectures. Integrated circuit development engineers have to overcome the problem of achieving high per...

  11. Enhancing the efficiency of silicon Raman converters

    Science.gov (United States)

    Vermeulen, Nathalie; Sipe, John E.; Thienpont, Hugo

    2010-05-01

    We propose a silicon ring Raman converter in which the spatial variation of the Raman gain along the ring for TE polarization is used to quasi-phase-match the CARS process. If in addition the pump, Stokes, and anti-Stokes waves involved in the CARS interaction are resonantly enhanced by the ring structure, the Stokes-to-anti-Stokes conversion efficiency can be increased by at least four orders of magnitude over that of one-dimensional perfectly phase-matched silicon Raman converters, and can reach values larger than unity with relatively low input pump intensities. These improvements in conversion performance could substantially expand the practical applicability of the CARS process for optical wavelength conversion.

  12. Integrated mode converter for mode division multiplexing

    Science.gov (United States)

    Perez-Galacho, Diego; Alonso-Ramos, Carlos Alberto; Marris-Morini, Delphine; Vakarin, Vladyslav; Le Roux, Xavier; Ortega-Moñux, Alejandro; Wangüemert-Perez, Juan Gonzalo; Vivien, Laurent

    2016-05-01

    The ever growing demands of bandwidth in optical communication systems are making traditional Wavelength Division Multiplexing (WDM) based systems to reach its limit. In order to cope with future bandwidth demand is necessary to use new levels of orthogonality, such as the waveguide mode or the polarization state. Mode Division Multiplexing (MDM) has recently attracted attention as a possible solution to increase aggregate bandwidth. In this work we discuss the proposition a of mode converter that can cover the whole C-Band of optical communications. The Mode Converter is based on two Multimode Interference (MMI) couplers and a phase shifter. Insertion loss (IL) below 0.2 dB and Extinction ratio (ER) higher than 20 dB in a broad bandwidth range of 1.5 μm to 1.6 μm have been estimated. The total length of the device is less than 30 μm.

  13. Strained quantum well photovoltaic energy converter

    Science.gov (United States)

    Freundlich, Alexandre (Inventor); Renaud, Philippe (Inventor); Vilela, Mauro Francisco (Inventor); Bensaoula, Abdelhak (Inventor)

    1998-01-01

    An indium phosphide photovoltaic cell is provided where one or more quantum wells are introduced between the conventional p-conductivity and n-conductivity indium phosphide layer. The approach allows the cell to convert the light over a wider range of wavelengths than a conventional single junction cell and in particular convert efficiently transparency losses of the indium phosphide conventional cell. The approach hence may be used to increase the cell current output. A method of fabrication of photovoltaic devices is provided where ternary InAsP and InGaAs alloys are used as well material in the quantum well region and results in an increase of the cell current output.

  14. Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1)

    DEFF Research Database (Denmark)

    Dettori, Rosalia; Sonzogni, Silvina; Meyer, Lucas;

    2009-01-01

    The members of the AGC kinase family frequently exhibit three conserved phosphorylation sites: the activation loop, the hydrophobic motif (HM), and the zipper (Z)/turn-motif (TM) phosphorylation site. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates the activation loop of...... numerous AGC kinases, including the protein kinase C-related protein kinases (PRKs). Here we studied the docking interaction between PDK1 and PRK2 and analyzed the mechanisms that regulate this interaction. In vivo labeling of recombinant PRK2 by (32)P(i) revealed phosphorylation at two sites, the...... the mechanism that negatively regulates the docking interaction of PRK2 to the upstream kinase PDK1 is directly linked to the activation mechanism of PRK2 itself. Finally, our results indicate that the mechanisms underlying the regulation of the interaction between PRK2 and PDK1 are specific for PRK2...

  15. Serum angiotensin converting enzyme in pneumonias.

    OpenAIRE

    Kerttula, Y; Weber, T H

    1986-01-01

    Serum concentrations of angiotensin converting enzyme (ACE) were studied in pneumonias caused by different pathogens and in cases in which the aetiology could not be defined. In all aetiological groups, except in viral pneumonia, there was a significant increase in ACE during recovery (p less than 0.001). In several patients the lowest values during the acute phase of disease and the highest values during recovery were outside the reference limits. In cases with known aetiology the highest AC...

  16. Emergency braking for free piston energy converters

    OpenAIRE

    West, M.; Long, S.; Wang, J; Bingham, Chris; Howe, D.

    2005-01-01

    Free piston energy converters are a potential technology for future hybrid vehicles, as well as stationary power generation applications. A candidate 2-stroke system comprises of two opposing combustion chambers with a common piston rod, and integrated with a tubular permanent magnet electrical machine for the conversion of mechanical to electrical energy. A key issue for the ultimate adoption of such systems, however, is their robustness in the event of a fault to enable a safe shutdown, wit...

  17. Modeling the bremsstrahlung emission from converters

    CERN Document Server

    Mirea, M; Clapier, F; Hassaïne, M; Ibrahim, F; Müller, A C; Pauwels, N; Proust, J; Verney, D; Antoni, R; Bourgeois, L; Kandri-Rody, S

    2001-01-01

    The bremsstrahlung angular and energy theoretical distributions delivered from W and UCx thick converters are reported. This study is focussed on initial kinetic energies of the electron beam included in the range 30-60 MeV, suitable for the production of large radiative yields able to induce the $^{238}$U fission. These results offer the possibility to evaluate the required shielding for a neutron rich nuclei source.

  18. Metamaterial Polarization Converter Analysis: Limits of Performance

    OpenAIRE

    Markovich, Dmitry L.; Andryieuski, Andrei; Zalkovskij, Maksim; Malureanu, Radu; Lavrinenko, Andrei V.

    2012-01-01

    In this paper we analyze the theoretical limits of a metamaterial converter that allows for linear-to- elliptical polarization transformation with any desired ellipticity and ellipse orientation. We employ the transmission line approach providing a needed level of the design generalization. Our analysis reveals that the maximal conversion e?ciency for transmission through a single metamaterial layer is 50%, while the realistic re ection con?guration can give the conversion e?ciency up to 90%....

  19. Multiport Resonant DC-DC Converter

    OpenAIRE

    Tran, Yan-Kim; Dujic, Drazen; Barrade, Philippe

    2015-01-01

    his paper presents a multiport galvanically isolated LLC resonant DC-DC converter suitable for DC applications. A three-port structure is analyzed, with full bidirectional power flow capabilities, simple control and behavior similar to that expected from a DC transformer. Each port is equipped with half-bridge modules accompanied with tuned resonant tank, partly realized with elements of a multi- winding high frequency transformer. With some restrictions that are explained in the paper, each ...

  20. Converting digital learning content into learning objects

    OpenAIRE

    Schreurs, Jeanne; Moreau, Rachel

    2006-01-01

    Our learning content can be structured as learning objects( LO) and as atomic learning objects (ALO). For both of them a set of metadata has been defined. The metadata follows the international standards on learning content. As a result the interoperability of the learning objects in different learning systems is being guaranteed. We are converting the digital learning content into LO's. A learning object is seen as a composition or a scenario model of a set of blocks. The blocks, presenting ...

  1. (Convertible) Undeniable Signatures Without Random Oracles

    Science.gov (United States)

    Yuen, Tsz Hon; Au, Man Ho; Liu, Joseph K.; Susilo, Willy

    We propose a convertible undeniable signature scheme without random oracles. Our construction is based on Waters' and Kurosawa and Heng's schemes that were proposed in Eurocrypt 2005. The security of our scheme is based on the CDH and the decision linear assumption. Comparing only the part of undeniable signatures, our scheme uses more standard assumptions than the existing undeniable signatures without random oracles due to Laguillamie and Vergnaud.

  2. Angiotensin Converting Enzyme Activity in Alopecia Areata

    OpenAIRE

    Mohammad Reza Namazi; Armaghan Ashraf; Farhad Handjani; Ebrahim Eftekhar; Amir Kalafi

    2014-01-01

    Background. Alopecia areata (AA) is a chronic inflammatory disease of the hair follicle. The exact pathogenesis of AA remains unknown, although recent studies support a T-cell mediated autoimmune process. On the other hand, some studies have proposed that the renin-angiotensin-aldosterone system (RAAS) may play a role in autoimmunity. Therefore, we assessed serum activity of angiotensin converting enzyme (ACE), a component of this system, in AA. Methods. ACE activity was measured in the sera ...

  3. Reversible thyristor converters of brushless synchronous compensators

    Directory of Open Access Journals (Sweden)

    А.М.Galynovskiy

    2013-12-01

    Full Text Available Behavior of models of three-phase-to-single-phase rotary reversible thyristor converters of brushless synchronous compensators in a circuit simulation system is analyzed. It is shown that combined control mode of opposite-connected thyristors may result in the exciter armature winding short circuits both at the thyristor feed-forward and lagging current delay angles. It must be taken into consideration when developing brushless compensator excitation systems.

  4. Online Scheduling in Distributed Message Converter Systems

    OpenAIRE

    Risse, Thomas; Wombacher, Andreas; Surridge, Mike; Taylor, Steve; Aberer, Karl

    2001-01-01

    The optimal distribution of jobs among hosts in distributed environments is an important factor to achieve high performance. The optimal strategy depends on the application. In this paper we present a new online scheduling strategy for distributed EDI converter system. The strategy is based on the Bin-Stretching approach. The original algorithm has been enhanced to satisfy the business goals of meeting deadlines, priority processing, low response time and high throughput. The algorithm can be...

  5. Fracture imaging with converted elastic waves

    Energy Technology Data Exchange (ETDEWEB)

    Nihei, K.T.; Nakagawa, S.; Myer, L.R.

    2001-05-29

    This paper examines the seismic signatures of discrete, finite-length fractures, and outlines an approach for elastic, prestack reverse-time imaging of discrete fractures. The results of this study highlight the importance of incorporating fracture-generated P-S converted waves into the imaging method, and presents an alternate imaging condition that can be used in elastic reverse-time imaging when a direct wave is recorded (e.g., for crosswell and VSP acquisition geometries).

  6. Optimizing Design of UHVDC Converter Stations

    Institute of Scientific and Technical Information of China (English)

    MA Weimin; NIE Dingzhen; CAO Yanming

    2012-01-01

    Based on the consultation and study for Xiangjiaba-Shanghai ±800 kV UHVDC(ultra high voltage direct current) project, this paper presents an optimal design for key technique solutions. In this paper, the DC system electrical scheme design, the DC filter design, the DC harmonic component suppression, the over voltage and insulation coordination, the requirements for converter station equipment, the main equipment technical parameters of equipment (including thyristor valve, converter transformer, smoothing reactor, DC breaker), the configuration of measuring device and DC control protection system, and the de-icing operation design are investigated. According to the UHVDC technology researched conclusions and the development of the project construction, the UHVDC system design for converter stations becomes an optimal combination. The optimized design solves numbers of technical problems of the world's first UHVDC project, and it is applied to the project's construction. Under the actual operating condition, the optimized design is proved to be correct and superior. These optimal design conclusions are impartment for developing UHVDC technique and equipment, and provide reference for future UHVDC projects.

  7. Protein Kinase D family kinases: roads start to segregate.

    Science.gov (United States)

    Wille, Christoph; Seufferlein, Thomas; Eiseler, Tim

    2014-01-01

    Highly invasive pancreatic tumors are often recognized in late stages due to a lack of clear symptoms and pose major challenges for treatment and disease management. Broad-band Protein Kinase D (PKD) inhibitors have recently been proposed as additional treatment option for this disease. PKDs are implicated in the control of cancer cell motility, angiogenesis, proliferation and metastasis. In particular, PKD2 expression is elevated in pancreatic cancer, whereas PKD1 expression is comparably lower. In our recent study we report that both kinases control PDAC cell invasive properties in an isoform-specific, but opposing manner. PKD1 selectively mediates anti-migratory/anti-invasive features by preferential regulation of the actin-regulatory Cofilin-phosphatase Slingshot1L (SSH1L). PKD2, on the other hand enhances invasion and angiogenesis of PDAC cells in 3D-ECM cultures and chorioallantois tumor models by stimulating expression and secretion of matrix-metalloproteinase 7 and 9 (MMP7/9). MMP9 also enhances PKD2-mediated tumor angiogenesis releasing extracellular matrix-bound VEGF-A. We thus suggest high PKD2 expression and loss of PKD1 may be beneficial for tumor cells to enhance their matrix-invading abilities. In our recent study we demonstrate for the first time PKD1 and 2 isoform-selective effects on pancreatic cancer cell invasion, in-vitro and in-vivo, defining isoform-specific regulation of PKDs as a major future issue. PMID:24847910

  8. MAP kinases and histone modification

    Institute of Scientific and Technical Information of China (English)

    Tamaki Suganuma; Jerry L. Workman

    2012-01-01

    Signal transduction pathways alter the gene expression program in response to extracellular or intracellular cues.Mitogen-activated protein kinases (MAPKs) govern numerous cellular processes including cell growth,stress response,apoptosis,and differentiation.In the past decade,MAPKs have been shown to regulate the transcription machinery and associate with chromatin-modifying complexes.Moreover,recent studies demonstrate that several MAPKs bind directly to chromatin at target genes.This review highlights the recent discoveries of MAPK signaling in regard to histone modifications and chromatin regulation.Evidence suggesting that further unknown mechanisms integrate signal transduction with chromatin biology is discussed.

  9. MST kinases in development and disease

    OpenAIRE

    Thompson, Barry J.; Sahai, Erik

    2015-01-01

    The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called STK3), MST3 (also called STK24), MST4, and YSK1 (also called STK25 or SOK1). MST kinases are emerging as key signaling molecules that influence cell proliferation, organ size, cell migration, and cell polarity. Here we review the regulation and function of these kinases in normal physiology and pathologies, including cance...

  10. Protein kinase profiling assays: a technology review.

    Science.gov (United States)

    Wang, Yuren; Ma, Haiching

    2015-11-01

    Protein kinases have become one of the most intensively pursued classes of drug targets for many diseases such as cancers and inflammatory diseases. Kinase profiling work seeks to understand general selectivity trends of lead compounds across the kinome, which help with target selection, compound prioritization, and potential implications in toxicity. Under the current drug discovery process, screening of compounds against comprehensive panels of kinases and their mutants has become the standard approach. Many screening assays and technologies which are compatible for high-throughput screening (HTS) against kinases have been extensively pursued and developed.

  11. One-Quadrant Switched-Mode Power Converters

    CERN Document Server

    Petrocelli, R

    2015-01-01

    This article presents the main topics related to one-quadrant power convert- ers. The basic topologies are analysed and a simple methodology to obtain the steady-state output–input voltage ratio is set out. A short discussion of dif- ferent methods to control one-quadrant power converters is presented. Some of the reported derived topologies of one-quadrant power converters are also considered. Some topics related to one-quadrant power converters such as syn- chronous rectification, hard and soft commutation, and interleaved converters are discussed. Finally, a brief introduction to resonant converters is given.

  12. Fault isolation in parallel coupled wind turbine converters

    DEFF Research Database (Denmark)

    Odgaard, Peter Fogh; Thøgersen, Paul Bach; Stoustrup, Jakob

    2010-01-01

    Parallel converters in wind turbine give a number advantages, such as fault tolerance due to the redundant converters. However, it might be difficult to isolate gain faults in one of the converters if only a combined power measurement is available. In this paper a scheme using orthogonal power...... references to the converters is proposed. Simulations on a wind turbine with 5 parallel converters show a clear potential of this scheme for isolation of this gain fault to the correct converter in which the fault occurs....

  13. Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.

    Science.gov (United States)

    Xue, Liang; Wang, Wen-Horng; Iliuk, Anton; Hu, Lianghai; Galan, Jacob A; Yu, Shuai; Hans, Michael; Geahlen, Robert L; Tao, W Andy

    2012-04-10

    Our understanding of the molecular control of many disease pathologies requires the identification of direct substrates targeted by specific protein kinases. Here we describe an integrated proteomic strategy, termed kinase assay linked with phosphoproteomics, which combines a sensitive kinase reaction with endogenous kinase-dependent phosphoproteomics to identify direct substrates of protein kinases. The unique in vitro kinase reaction is carried out in a highly efficient manner using a pool of peptides derived directly from cellular kinase substrates and then dephosphorylated as substrate candidates. The resulting newly phosphorylated peptides are then isolated and identified by mass spectrometry. A further comparison of these in vitro phosphorylated peptides with phosphopeptides derived from endogenous proteins isolated from cells in which the kinase is either active or inhibited reveals new candidate protein substrates. The kinase assay linked with phosphoproteomics strategy was applied to identify unique substrates of spleen tyrosine kinase (Syk), a protein-tyrosine kinase with duel properties of an oncogene and a tumor suppressor in distinctive cell types. We identified 64 and 23 direct substrates of Syk specific to B cells and breast cancer cells, respectively. Both known and unique substrates, including multiple centrosomal substrates for Syk, were identified, supporting a unique mechanism that Syk negatively affects cell division through its centrosomal kinase activity. PMID:22451900

  14. Comparison of Peptide Array Substrate Phosphorylation of c-Raf and Mitogen Activated Protein Kinase Kinase Kinase 8

    NARCIS (Netherlands)

    Parikh, Kaushal; Diks, Sander H.; Tuynman, Jurriaan H. B.; Verhaar, Auke; Lowenberg, Mark; Hommes, Daan W.; Joore, Jos; Pandey, Akhilesh; Peppelenbosch, Maikel P.

    2009-01-01

    Kinases are pivotal regulators of cellular physiology. The human genome contains more than 500 putative kinases, which exert their action via the phosphorylation of specific substrates. The determinants of this specificity are still only partly understood and as a consequence it is difficult to pred

  15. Novel Library of Selenocompounds as Kinase Modulators

    Directory of Open Access Journals (Sweden)

    Carmen Sanmartín

    2011-07-01

    Full Text Available Although the causes of cancer lie in mutations or epigenic changes at the genetic level, their molecular manifestation is the dysfunction of biochemical pathways at the protein level. The 518 protein kinases encoded by the human genome play a central role in various diseases, a fact that has encouraged extensive investigations on their biological function and three dimensional structures. Selenium (Se is an important nutritional trace element involved in different physiological functions with antioxidative, antitumoral and chemopreventive properties. The mechanisms of action for selenocompounds as anticancer agents are not fully understood, but kinase modulation seems to be a possible pathway. Various organosulfur compounds have shown antitumoral and kinase inhibition effects but, in many cases, the replacement of sulfur by selenium improves the antitumoral effect of compounds. Although Se atom possesses a larger atomic volume and nucleophilic character than sulfur, Se can also formed interactions with aminoacids of the catalytic centers of proteins. So, we propose a novel chemical library that includes organoselenium compounds as kinase modulators. In this study thirteen selenocompounds have been evaluated at a concentration of 3 or 10 µM in a 24 kinase panel using a Caliper LabChip 3000 Drug Discover Platform. Several receptor (EGFR, IGFR1, FGFR1… and non-receptor (Abl kinases have been selected, as well as serine/threonine/lipid kinases (AurA, Akt, CDKs, MAPKs… implicated in main cancer pathways: cell cycle regulation, signal transduction, angiogenesis regulation among them. The obtained results showed that two compounds presented inhibition values higher than 50% in at least four kinases and seven derivatives selectively inhibited one or two kinases. Furthermore, three compounds selectively activated IGF-1R kinase with values ranging from −98% to −211%. In conclusion, we propose that the replacement of sulfur by selenium seems to be

  16. Induction of Macrophage Function in Human THP-1 Cells is Associated with MAPK Signaling and Activation of MAP3K7 (TAK1 Protein Kinase

    Directory of Open Access Journals (Sweden)

    Erik eRichter

    2016-03-01

    Full Text Available Macrophages represent the primary human host response to pathogen infection and link the immediate defense to the adaptive immune system. Mature tissue macrophages convert from circulating monocyte precursor cells by terminal differentiation in a process that is not fully understood. Here, we analyzed the protein kinases of the human monocytic cell line THP-1 before and after induction of macrophage differentiation by using kinomics and phosphoproteomics. When comparing the macrophage-like state with the monocytic precursor, 50% of the kinome was altered in expression and even 71% of covered kinase phosphorylation sites were affected. Kinome rearrangements are for example characterized by a shift of overrepresented cycline-dependent kinases associated with cell cycle control in monocytes to calmodulin-dependent kinases and kinases involved in proinflammatory signaling. Eventually, we show that monocyte-to-macrophage differentiation is associated with major rewiring of mitogen-activated protein kinase signaling networks and demonstrate that protein kinase MAP3K7 (TAK1 acts as the key signaling hub in bacterial killing, chemokine production and differentiation. Our study proves the fundamental role of protein kinases and cellular signaling as major drivers of macrophage differentiation and function. The finding that MAP3K7 is central to macrophage function suggests MAP3K7 and its networking partners as promising targets in host-directed therapy for macrophage-associated disease.

  17. Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells

    International Nuclear Information System (INIS)

    An inhibitor of the insulin receptor tyrosine kinase (IRTK), (hydroxy-2-napthalenylmethyl)phosphonic acid, was designed and synthesized and was shown to be an inhibitor of the biological effects of insulin in vitro. With a wheat germ purified human placental insulin receptor preparation, this compound inhibited the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor. The ability of the kinase to phosphorylate an exogenous peptide substrate, angiotensin II, was also inhibited. Half-maximal inhibition of basal and insulin-stimulated human placental IRTK activity was found at concentrations of 150 and 100 μM, respectively, with 2 mM angiotensin II as the peptide substrate. The inhibitor was found to be specific for tyrosine kinases over serine kinases and noncompetitive with ATP. The inhibitor was converted into various (acyloxy)methyl prodrugs in order to achieve permeability through cell membranes. These prodrugs inhibited insulin-stimulated autophosphorylation of the insulin receptor 95-kDa β-subunit in intact CHO cells transfected with human insulin receptor. Inhibition of insulin-stimulated glucose oxidation in isolated rat adipocytes and 2-deoxyglucose uptake into CHO cells was observed with these prodrugs. The data provide additional evidence for the involvement of the insulin receptor tyrosine kinase in the regulation of glucose uptake and metabolism. These results and additional data reported herein suggest that this class of prodrugs and inhibitors will be useful for modulating the activity of a variety of tyrosine kinases

  18. Comparison between the Performance of Basic SEPIC Converter and modified SEPIC Converter with PI Controller

    Directory of Open Access Journals (Sweden)

    Satyendra Kumar Gupta

    2014-08-01

    Full Text Available There are multiple solutions in which line current is sinusoidal. In addition, in the recent years, a great number of circuits have been proposed with non sinusoidal line current. In this paper, a review of the most interesting solutions for single phase and low power applications is carried out. They are classified attending to the line current waveform, energy processing, number of switches, control loops, etc. The major advantages and disadvantages are highlighted and the field of application is found. The paper presents performance analysis of modified SEPIC dc-dc converter with low input voltage and wide output voltage range. The operational analysis and the design is done for the 380W power output of the modified converter. The simulation results of modified SEPIC converter are obtained with PI controller for the output voltage. The results obtained with the modified converter are compared with the basic SEPIC converter topology for the rise time, peak time, settling time and steady state error of the output response for open loop. Voltage tracking curve is also shown for wide output voltage range.

  19. A resonant dc-dc power converter assembly

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a resonant DC-DC power converter assembly comprising a first resonant DC-DC power converter and a second resonant DC-DC power converter having identical circuit topologies. A first inductor of the first resonant DC-DC power converter and a second inductor...... of the second resonant DC-DC power converter are configured for magnetically coupling the first and second resonant DC-DC power converters to each other to forcing substantially 180 degrees phase shift, or forcing substantially 0 degree phase shift, between corresponding resonant voltage waveforms of the first...... and second resonant DC-DC power converters. The first and second inductors are corresponding components of the first and second resonant DC-DC power converters....

  20. Dc to ac converter operates efficiently at low input voltages

    Science.gov (United States)

    1965-01-01

    Self-oscillating dc to ac converter with transistor switching to produce a square wave output is used for low and high voltage power sources. The converter has a high efficiency throughout a wide range of loads.

  1. A Three-Phase Interleaved Floating Output Boost Converter

    Directory of Open Access Journals (Sweden)

    Ajmal Farooq

    2015-01-01

    Full Text Available High step-up dc-dc converter is an essential part in several renewable energy systems. In this paper, a new topology of step-up dc-dc converter based on interleaved structure is proposed. The proposed converter uses three energy storing capacitors to achieve a high voltage gain. Besides the high voltage gain feature, the proposed converter also reduces the voltage stress across the semiconductor switches. This helps in using low rating switching devices which can reduce the overall size and cost of the converter. The operating principle of the proposed converter is discussed in detail and its principle waveforms are analyzed. An experiment is carried out on a 20 V input, 130 V output, and 21 W power prototype of the proposed converter in the laboratory to verify the performance of the proposed converter. An efficiency of 91.3% is achieved at the rated load.

  2. A novel viral thymidylate kinase with dual kinase activity.

    Science.gov (United States)

    Guevara-Hernandez, Eduardo; Arvizu-Flores, Aldo A; Lugo-Sanchez, Maria E; Velazquez-Contreras, Enrique F; Castillo-Yañez, Francisco J; Brieba, Luis G; Sotelo-Mundo, Rogerio R

    2015-10-01

    Nucleotide phosphorylation is a key step in DNA replication and viral infections, since suitable levels of nucleotide triphosphates pool are required for this process. Deoxythymidine monophosphate (dTMP) is produced either by de novo or salvage pathways, which is further phosphorylated to deoxythymidine triphosphate (dTTP). Thymidyne monophosphate kinase (TMK) is the enzyme in the junction of both pathways, which phosphorylates dTMP to yield deoxythymidine diphosphate (dTDP) using adenosine triphosphate (ATP) as a phosphate donor. White spot syndrome virus (WSSV) genome contains an open reading frame (ORF454) that encodes a thymidine kinase and TMK domains in a single polypeptide. We overexpressed the TMK ORF454 domain (TMKwssv) and its specific activity was measured with dTMP and dTDP as phosphate acceptors. We found that TMKwssv can phosphorylate dTMP to yield dTDP and also is able to use dTDP as a substrate to produce dTTP. Kinetic parameters K M and k cat were calculated for dTMP (110 μM, 3.6 s(-1)), dTDP (251 μM, 0.9 s(-1)) and ATP (92 μM, 3.2 s(-1)) substrates, and TMKwssv showed a sequential ordered bi-bi reaction mechanism. The binding constants K d for dTMP (1.9 μM) and dTDP (10 μM) to TMKwssv were determined by Isothermal Titration Calorimetry. The affinity of the nucleotidic analog stavudine monophosphate was in the same order of magnitude (K d 3.6 μM) to the canonical substrate dTMP. These results suggest that nucleotide analogues such as stavudine could be a suitable antiviral strategy for the WSSV-associated disease.

  3. Induction heating: fundamentals and choice criteria for frequency converters

    Energy Technology Data Exchange (ETDEWEB)

    Nuns, J.; Peureux, J.L. [Electricite de France (EDF), 75 - Paris (France)

    1995-10-01

    Induction heating imposes the induced current frequency; this frequency depends on the size and the materials to heat, thus a frequency converter is often necessary. In the case of induction heating, those converters are always resonance power supplies. Modern frequency converters include power electronics switches (thyristors, GTO thyristors, bipolar transistors, IGBT, field effect transistors). The more used converter is the current inverter which feeds a parallel oscillating circuit. (authors). 3 refs., 16 figs., 1 tab.

  4. Three-phase Resonant DC-link Converter

    OpenAIRE

    Munk-Nielsen, Stig

    1997-01-01

    The purpose of the project is to develop a three-phase resonant converter suitable for standard speed drives. The motivation for working with resonant converters is found in the problem of the standard converter type used today. In standard converter type Pulse Width Modulated-Voltage Source Inverter, PWM-VSI, the switches are subject to high current and voltage stress during switching, which causes losses. The fast switching of modern switches reduces switching losses. Unfortunately this pro...

  5. Design & Implementation of Zero Voltage Switching Buck Converter

    OpenAIRE

    A.Suresh Kumar; P.Krishna Reddy

    2014-01-01

    Zero voltage switching (ZVS) buck converter is more preferable over hard switched buck converter for low power, high frequency DC-DC conversion applications. In Zero voltage switching converter, turn on & turn off of a switch occurs at zero voltage that results in lower switching losses. In this converter soft switching is achieved by using resonant components. The optimal values of resonant components are determined by using electric functions derived from circuit configurati...

  6. Design of Monolithic Integrator for Strain-to-Frequency Converter

    OpenAIRE

    Tuan Mohd. Khairi Tuan Mat; Chew Sue Ping; Akram Abdul Azid

    2012-01-01

    Strain-to-Frequency converter (SFC) is a one of the analog conditioner tools that converts any strain signal to the frequency signal. The basic concept of SFC is by detecting any changing of strains, then converting the strain to the voltage signal and converting the voltage signal to the frequency signal. This tool consists of 3 main  components which are strain gauge, differential integrator and comparator. This paper presents the designing and analysis of monolithic integrator that to be u...

  7. A Composite PWM Control Strategy for Boost Converter

    Science.gov (United States)

    Qingfeng, Liu; Zhaoxia, Leng; Jinkun, Sun; Huamin, Wang

    In order to improve the control performance of boost converter with large signal disturbance, a composite PWM control strategy for boost converter operating in continuous condition mode (CCM) was proposed in this paper. The parasitical loss of Boost converter was analyzed and a loss compensation strategy was adopted to design feed-forward tracker for converter. The composite PWM controller consisted of the tracker and PID controller. Simulation and experiment results validated the validity of the control strategy presented in this paper.

  8. Convertible Subordinated Debt Financing and Optimal Investment Timing

    OpenAIRE

    Kyoko Yagi; Ryuta Takashima

    2010-01-01

    In this paper, we examine the optimal investment policy of the firm which is financed by issuing equity, straight debt and convertible debt with the senior-sub structure. The senior-sub structure gives preference to straight debt over convertible debt and to convertible debt over equity when the default occurs. We investigate how the senior-sub structure affects the optimal policies for default, conversion and investment the values of equity, straight debt, convertible debt and investment. In...

  9. Simulation of New Switched Capacitance Power Converter for Srm

    Directory of Open Access Journals (Sweden)

    S. M. Mohamed Saleem

    2014-06-01

    Full Text Available In this paper, design and simulation of switched capacitance power converter are proposed for 6/4 switched reluctance motor (SRM drive. The operating principle and design consideration of the proposed converter is explained. The proposed converter performance is better in reduction of torque ripple and constant speed can be achieved quickly with reduced power loss when compared with asymmetric converter. The proposed system is simulated by using MATLAB Simulink and their results are clearly presented.

  10. A New Modular Multilevel Converter with Integrated Energy Storage

    DEFF Research Database (Denmark)

    Trintis, Ionut; Munk-Nielsen, Stig; Teodorescu, Remus

    2011-01-01

    This paper introduces a new modular converter with integrated energy storage based on the cascaded half-bridge modular multilevel converter with common DC bus. It represents a complete modular solution with power electronics and energy storage building blocks, for medium and high voltage...... in the future HVDC meshed grids. Its functionality and flexibility makes the converter independent on the energy storage unit characteristic. The converter concept with its basic functions and control schemes are described and evaluated in this paper....

  11. Pricing Chinese Convertible Bonds with Dynamic Credit Risk

    OpenAIRE

    Ping Li; Jing Song

    2014-01-01

    To price convertible bonds more precisely, least squares Monte Carlo (LSM) method is used in this paper for its advantage in handling the dependence of derivatives on the path, and dynamic credit risk is used to replace the fixed one to make the value of convertible bonds reflect the real credit risk. In the empirical study, we price convertible bonds based on static credit risk and dynamic credit risk, respectively. Empirical results indicate that the ICBC convertible bond has been overprice...

  12. Microcontroller based phase control circuit for resonant power converters

    OpenAIRE

    Milcevski, Dejan; Stefanov, Goce; Karadzinov, Ljupco

    2011-01-01

    A microcontroller based circuit is developed for driving the IGBT switches of a bridge resonant power converter used for induction heating of metals. When a resonant power converter is used for induction heating the load is variable due to the effects of the heating process making the converter to operate out of resonance. This effect decreases the converter output power and increases switching loses. In order to maintain constant output power operating constantly on the resonant frequency a ...

  13. Estimation on the switching losses at IGBT bridges power converter

    OpenAIRE

    Stefanov, Goce; Karacinov, Ljupco; Cundev, Dobri

    2011-01-01

    ABSTRACT. In the paper estimation on the switching losses at IGBT bridge converter with the output serial resonant load is given. The converter works on frequency higher than resonant frequency and supports the work of IGBT transistors in the bridge with zero voltage turn on. In the analysis of the converter, PowerSim and SemiSiel simulation programs is used. The results to the switching losses estimated by simulation are compared with the results in a practical realized converter.

  14. Method for Converter Synchronization with RF Injection

    Directory of Open Access Journals (Sweden)

    Joshua P. Bruckmeyer

    2015-09-01

    Full Text Available This paper presents an injection method for synchronizing analog to digital converters (ADC. This approach can eliminate the need for precision routed discrete synchronization signals of current technologies, such as JESD204. By eliminating the setup and hold time requirements at the conversion (or near conversion clock rate, higher sample rate systems can be synchronized. Measured data from an existing multiple ADC conversion system was used to evaluate the method. Coherent beams were simulated to measure the effectiveness of the method. The results show near theoretical coherent processing gain.

  15. Nonlinear control design for wave energy converter

    OpenAIRE

    Galván García, Bruno

    2013-01-01

    In this thesis, we study the optimization of a single-piston pump system for use in a new wave energy converter by using a feedback mechanism. The first part of the thesis is dedicated to the optimal determination of control variables using the dynamical model of the single-piston pump system, which is a switched system that is built on first principles and describes the dynamics of four main important elements of the system: the buoy, the rod, the piston and the pumped water. ...

  16. Waste Plastic Converting into Hydrocarbon Fuel Materials

    Energy Technology Data Exchange (ETDEWEB)

    Sarker, Moinuddin; Mamunor Rashid, Mohammad; Molla, Mohammad

    2010-09-15

    The increased demand and high prices for energy sources are driving efforts to convert organic compounds into useful hydrocarbon fuels. Although much of this work has focused on biomass, there are strong benefits to deriving fuels from waste plastic material. Natural State Research Inc. (NSR) has invented a simple and economically viable process to decompose the hydrocarbon polymers of waste plastic into the shorter chain hydrocarbon of liquid fuel (patent pending). The method and principle of the production / process will be discussed. Initial tests with several widely used polymers indicate a high potential for commercialization.

  17. Power converters for medium voltage networks

    CERN Document Server

    Islam, Md Rabiul; Zhu, Jianguo

    2014-01-01

    This book examines a number of topics, mainly in connection with advances in semiconductor devices and magnetic materials and developments in medium and large-scale renewable power plant technologies, grid integration techniques and new converter topologies, including advanced digital control systems for medium-voltage networks. The book's individual chapters provide an extensive compilation of fundamental theories and in-depth information on current research and development trends, while also exploring new approaches to overcoming some critical limitations of conventional grid integration te

  18. Converting energy from fusion into useful forms

    OpenAIRE

    Kovari, M.; Harrington, C.; Jenkins, I; Kiely, C

    2013-01-01

    If fusion power reactors are to be feasible, it will still be necessary to convert the energy of the nuclear reaction into usable form. The heat produced will be removed from the reactor core by a primary coolant, which might be water, helium, molten lithium-lead, molten lithium-containing salt, or CO2. The heat could then be transferred to a conventional Rankine cycle or Brayton (gas turbine) cycle. Alternatively it could be used for thermochemical processes such as producing hydrogen or oth...

  19. EMI filter techniques in power electronic converters

    Directory of Open Access Journals (Sweden)

    Fredy Edimer Hoyos Velasco

    2012-04-01

    Full Text Available This paper presents the results of EMI reduction techniques applied to power electronic converters. The techniques applied included shielding control and power signals, separating power system references regarding reference for instrumentation and measurement signals, implementing analog filters and configuring an appropriate switch trigger system for electronic power to decrease shifting EMI emissions to the maximum. This paper presents the results before and after applying the techniques to reduce interference. The results were also veryfied by using two real time control strategies rapid control prototyping (RCP.

  20. Converting skeletal structures to quad dominant meshes

    DEFF Research Database (Denmark)

    Bærentzen, Jakob Andreas; Misztal, Marek Krzysztof; Welnicka, Katarzyna

    2012-01-01

    We propose the Skeleton to Quad-dominant polygonal Mesh algorithm (SQM), which converts skeletal structures to meshes composed entirely of polar and annular regions. Both types of regions have a regular structure where all faces are quads except for a single ring of triangles at the center of each...... polar region. The algorithm produces high quality meshes which contain irregular vertices only at the poles or where several regions join. It is trivial to produce a stripe parametrization for the output meshes which also lend themselves well to polar subdivision. After an initial description of SQM, we...

  1. Solid state transport-based thermoelectric converter

    Science.gov (United States)

    Hu, Zhiyu

    2010-04-13

    A solid state thermoelectric converter includes a thermally insulating separator layer, a semiconducting collector and an electron emitter. The electron emitter comprises a metal nanoparticle layer or plurality of metal nanocatalyst particles disposed on one side of said separator layer. A first electrically conductive lead is electrically coupled to the electron emitter. The collector layer is disposed on the other side of the separator layer, wherein the thickness of the separator layer is less than 1 .mu.m. A second conductive lead is electrically coupled to the collector layer.

  2. Near-Shore Floating Wave Energy Converters

    DEFF Research Database (Denmark)

    Ruol, Piero; Zanuttigh, Barbara; Martinelli, Luca;

    2011-01-01

    and transmission characteristics are approximated to functions of wave height, period and obliquity. Their order of magnitude are 20% and 80%, respectively. It is imagined that an array of DEXA is deployed in front of Marina di Ravenna beach (IT), a highly touristic site of the Adriatic Coast. Based on the CERC......Aim of this note is to analyse the possible application of a Wave Energy Converter (WEC) as a combined tool to protect the coast and harvest energy. Physical model tests are used to evaluate wave transmission past a near-shore floating WEC of the wave activated body type, named DEXA. Efficiency...

  3. Design, modeling and testing of data converters

    CERN Document Server

    Kiaei, Sayfe; Xu, Fang

    2014-01-01

    This book presents the a scientific discussion of the state-of-the-art techniques and designs for modeling, testing and for the performance analysis of data converters. The focus is put on sustainable data conversion. Sustainability has become a public issue that industries and users can not ignore. Devising environmentally friendly solutions for data conversion designing, modeling and testing is nowadays a requirement that researchers and practitioners must consider in their activities. This book presents the outcome of the IWADC workshop 2011, held in Orvieto, Italy.

  4. Converting Student Support Services to Online Delivery

    Directory of Open Access Journals (Sweden)

    David E. Brigham

    2001-01-01

    Full Text Available This case study describes how Regents College (soon to be Excelsior College, an accredited, private, distance education institution with administrative offices in Albany, New York addressed the structural, management, and resource issues that came into play when converting distance education programs from print-based and telephone delivery to online delivery. The study uses a systems framework to describe and analyze the circumstances and issues surrounding the creation of six student support services: electronic advising, an electronic peer network, an online database of distance courses, an online bookstore, a virtual library, and an alumni services website.

  5. Genetics Home Reference: pyruvate kinase deficiency

    Science.gov (United States)

    ... National (UK) Information Centre for Metabolic Diseases National Organization for Rare Disorders (NORD): Pyruvate Kinase Deficiency Genetic Testing Registry (1 link) Pyruvate kinase deficiency of red cells Scientific articles on PubMed (1 link) PubMed OMIM (1 link) ...

  6. Multi Port Single Stage Power Electronics Converter and Wind PFC Converter for DC Micro Grid Applications

    Directory of Open Access Journals (Sweden)

    M. Hemachandran

    2014-08-01

    Full Text Available In this study multi port AC/DC-DC single stage power electronics converter proposed for grid power supply. The topology includes reduced number of active element and passive element. Passive element is used to provide to achieve improved voltage gain and to reduce the voltage stress of input side switches. The active-clamp circuits are used to recycle the energy stored in the leakage inductors and to improve the system performances. Here two input port (wind and battery unit and output port connected to dc grid, battery act as charge unit and source. Efficient wind power conversion is achieved by PFC boost dc-dc converter. Controlled and high step up voltage is supplied to multi-port converter from wind source.

  7. Convertible Arbitrage Price Pressure and Short-Sale Constraints

    NARCIS (Netherlands)

    de Jong, Abe; Dutordoir, Marie; van Genuchten, Nathalie; Verwijmeren, Patrick

    2012-01-01

    Using a sample of 4,148 convertibles issued over 1990-2009 by companies listed in 35 countries, the authors exploited worldwide differences in short-sale constraints to examine whether short selling by convertible arbitrageurs creates downward pressure on convertible issuers' stock prices. They foun

  8. 40 CFR 90.319 - NOX converter check.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false NOX converter check. 90.319 Section 90... Provisions § 90.319 NOX converter check. (a) The efficiency of the converter used for the conversion of NO2... percent of the NO concentration). The NOX analyzer must be in the NO mode so that the span gas does...

  9. SWITCHED-CAPACITOR BASED STEP-DOWN RESONANT CONVERTERS

    Institute of Scientific and Technical Information of China (English)

    Y.P.B.Yeung; K.W.E.Cheng; K.K.Law

    2001-01-01

    A family of switched-capacitor based resonant converters is present.All converters are in step-downmode.By adding different number of switched-capacitor cells,different output voltage conversion ratio can beobtained.All switching devices in the converters operate under zero-current switching.Both high frequencyoperations and high efficiency are possible.

  10. 31 CFR 800.206 - Convertible voting instrument.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Convertible voting instrument. 800..., AND TAKEOVERS BY FOREIGN PERSONS Definitions § 800.206 Convertible voting instrument. The term convertible voting instrument means a financial instrument that currently does not entitle its owner or...

  11. New active load voltage clamp for HF-link converters

    DEFF Research Database (Denmark)

    Ljusev, Petar; Andersen, Michael Andreas E.

    2005-01-01

    This paper proposes a new active clamp for HF-link converters, which features very high efficiency by returning the clamped energy back to the primary side through a small auxiliary converter. It also increases the reliability of HF-link converters by providing an alternative load current path du...

  12. Impedance Interaction Modeling and Analysis for Bidirectional Cascaded Converters

    DEFF Research Database (Denmark)

    Tian, Yanjun; Deng, Fujin; Chen, Zhe;

    2015-01-01

    For the cascaded converter system, the output impedance of source converter interacts with the input impedance of load converter, and the interaction may cause the system instability. In bidirectional applications, when the power flow is reversed, the impedance interaction also varies, which brin...

  13. Aurora kinase inhibitors: current status and outlook

    Directory of Open Access Journals (Sweden)

    Vassilios eBavetsias

    2015-12-01

    Full Text Available The Aurora kinase family comprises of cell cycle-regulated serine/threonine kinases important for mitosis. Their activity and protein expression are cell cycle regulated, peaking during mitosis to orchestrate important mitotic processes including centrosome maturation, chromosome alignment, chromosome segregation and cytokinesis. In humans, the Aurora kinase family consists of three members; Aurora-A, Aurora-B and Aurora-C, that each share a conserved C-terminal catalytic domain but differ in their sub-cellular localization, substrate specificity and function during mitosis. In addition, Aurora-A and Aurora-B have been found to be overexpressed in a wide variety of human tumors. These observations led to a number of programs among academic and pharmaceutical organizations to discovering small molecule Aurora kinase inhibitors as anti-cancer drugs. This review will summarize the known Aurora kinase inhibitors currently in the clinic and the current and future directions.

  14. Selective regulation of MAP kinase signaling by an endomembrane phosphatidylinositol 4-kinase.

    Science.gov (United States)

    Cappell, Steven D; Dohlman, Henrik G

    2011-04-29

    Multiple MAP kinase pathways share components yet initiate distinct biological processes. Signaling fidelity can be maintained by scaffold proteins and restriction of signaling complexes to discreet subcellular locations. For example, the yeast MAP kinase scaffold Ste5 binds to phospholipids produced at the plasma membrane and promotes selective MAP kinase activation. Here we show that Pik1, a phosphatidylinositol 4-kinase that localizes primarily to the Golgi, also regulates MAP kinase specificity but does so independently of Ste5. Pik1 is required for full activation of the MAP kinases Fus3 and Hog1 and represses activation of Kss1. Further, we show by genetic epistasis analysis that Pik1 likely regulates Ste11 and Ste50, components shared by all three MAP kinase pathways, through their interaction with the scaffold protein Opy2. These findings reveal a new regulator of signaling specificity functioning at endomembranes rather than at the plasma membrane. PMID:21388955

  15. Efficiency and reliability improvement in wind turbine converters by grid converter adaptive control

    DEFF Research Database (Denmark)

    Trintis, Ionut; Munk-Nielsen, Stig; Abrahamsen, Flemming;

    2013-01-01

    and generator side. Operating in this way, the electrical and thermal stress factors are decreased on the power electronic devices, increasing their lifetime. The simulation results using this method show efficiency increase and devices temperature cycles slightly decreased. Experimental results on a...... wind turbine power stack shows efficiency increase in the high power region.......This paper presents a control method that reduces the losses in wind turbine converters adaptively controlling the grid converter. The dc-link voltage adapts its reference based on the system state and therefore reduces the stored energy, and is therefore kept at the minimum necessary for the grid...

  16. A waveguide-typed plasmonic mode converter.

    Science.gov (United States)

    Park, Hae-Ryeong; Park, Jong-Moon; Kim, Min-Su; Lee, Myung-Hyun

    2012-08-13

    Waveguide-typed plasmonic mode converters (WPMCs) at a wavelength of 1.55 μm are presented. The WPMC is composed of an insulator-metal-insulator waveguide (IMI-W), a 1st reversely tapered insulator-metal-insulator-metal-insulator waveguide (RT-IMIMI-W), an insulator-metal-insulator-metal-insulator waveguide (IMIMI-W), a 2nd RT-IMIMI-W with lateral silver mirrors (LSMs), and a metal-insulator-metal waveguide (MIM-W) in series. The mode sizes for the IMI-W, IMIMI-W, and MIM-W via the IMIMI-W with LSMs were not only calculated using a finite element method but were also experimentally measured. The input mode size of 10.3 μm × 10.3 μm from a polarization-maintaining single-mode fiber was squeezed to the mode size of ~2.9 μm × 2.9 μm in measurement by converting an s0 mode to an Sa0 mode via an Ss0 mode. The WPMC may be potentially useful for bridging micro- to nano-plasmonic integrated circuits. PMID:23038504

  17. A novel converter topology for TEM applications

    Indian Academy of Sciences (India)

    S Kedarnath; Krishna Vasudevan

    2008-10-01

    Time-domain Electro Magnetic (TEM) systems, are used for remote sensing of conductive mineral deposits buried under the surface of the earth. A low frequency trapezoidal current excitation set-up in an exciter coil loop causes a flux that penetrates deep into the earth. When the excitation is cut off sharply, conductive deposits in the earth carrying flux react by causing eddy current flows within them. The flux produced by such eddy currents is picked up by a sensor coil. By comparing the emf induced in the sensor coil with a priori known emf patterns for mineral deposits, the presence of mineral deposits can be ascertained. The voltage, current and energy levels of the TEM system, require special type of excitation technique. Power converters for such non-standard requirements are not reported in the literature, particularly for TEM applications. This paper introduces TEM systems to the reader and presents the requirements for excitation. A converter topology to meet the requirements, it’s analysis, control and performance are presented. Among other alternatives that the authors have attempted, the topology presented features reduced number of passive elements, high voltage gain and low losses. These features enable the sensor head to be operated from the normal low level battery.

  18. Wind Energy Conversion Based on Matrix Converter

    Directory of Open Access Journals (Sweden)

    Mutharasan Anburaj

    2014-07-01

    Full Text Available In recent years renewable sources such as solar, wave and wind are used for the generation of electricity. Wind is one of the major renewable sources. The amount of energy from a Wind Energy Conversion System (WECS depends not only on the wind at the site, but also on the control strategy used for the WECS. In assistance to get the appropriate wind energy from the conversion system, wind turbine generator will be run in variable speed mode. The variable speed capability is achieved through the use of an advanced power electronic converter. Fixed speed wind turbines and induction generators are often used in wind farms. But the limitations of such generators are low efficiency and poor power quality which necessitates the variable speed wind turbine generators such as Doubly Fed Induction Generator (DFIG and Permanent Magnet Synchronous Generator (PMSG. A high-performance configuration can be obtained by using Scherbius drive composed of a DFIG and a converter in combination AC-DC-AC connect between stator & rotor points for providing the required variable speed operation

  19. CCLIBS: The CERN Power Converter Control Libraries

    CERN Document Server

    AUTHOR|(SzGeCERN)404953; Lebioda, Krzysztof Tomasz; Magrans De Abril, Marc; Martino, Michele; Murillo Garcia, Raul; Nicoletti, Achille

    2015-01-01

    Accurate control of power converters is a vital activity in large physics projects. Several different control scenarios may coexist, including regulation of a circuit’s voltage, current, or field strength within a magnet. Depending on the type of facility, a circuit’s reference value may be changed asynchronously or synchronously with other circuits. Synchronous changes may be on demand or under the control of a cyclic timing system. In other cases, the reference may be calculated in real-time by an outer regulation loop of some other quantity, such as the tune of the beam in a synchrotron. The power stage may be unipolar or bipolar in voltage and current. If it is unipolar in current, it may be used with a polarity switch. Depending on the design, the power stage may be controlled by a firing angle or PWM duty-cycle reference, or a voltage or current reference. All these cases are supported by the CERN Converter Control Libraries (CCLIBS). These open-source C libraries include advanced reference generati...

  20. Forback DC-to-DC converter

    Science.gov (United States)

    Lukemire, Alan T.

    1995-05-01

    A pulse-width modulated DC-to-DC power converter including a first inductor, i.e. a transformer or an equivalent fixed inductor equal to the inductance of the secondary winding of the transformer, coupled across a source of DC input voltage via a transistor switch which is rendered alternately conductive (ON) and nonconductive (OFF) in accordance with a signal from a feedback control circuit is described. A first capacitor capacitively couples one side of the first inductor to a second inductor which is connected to a second capacitor which is coupled to the other side of the first inductor. A circuit load shunts the second capacitor. A semiconductor diode is additionally coupled from a common circuit connection between the first capacitor and the second inductor to the other side of the first inductor. A current sense transformer generating a current feedback signal for the switch control circuit is directly coupled in series with the other side of the first inductor so that the first capacitor, the second inductor and the current sense transformer are connected in series through the first inductor. The inductance values of the first and second inductors, moreover, are made identical. Such a converter topology results in a simultaneous voltsecond balance in the first inductance and ampere-second balance in the current sense transformer.

  1. Serial Pixel Analog-to-Digital Converter

    Energy Technology Data Exchange (ETDEWEB)

    Larson, E D

    2010-02-01

    This method reduces the data path from the counter to the pixel register of the analog-to-digital converter (ADC) from as many as 10 bits to a single bit. The reduction in data path width is accomplished by using a coded serial data stream similar to a pseudo random number (PRN) generator. The resulting encoded pixel data is then decoded into a standard hexadecimal format before storage. The high-speed serial pixel ADC concept is based on the single-slope integrating pixel ADC architecture. Previous work has described a massively parallel pixel readout of a similar architecture. The serial ADC connection is similar to the state-of-the art method with the exception that the pixel ADC register is a shift register and the data path is a single bit. A state-of-the-art individual-pixel ADC uses a single-slope charge integration converter architecture with integral registers and “one-hot” counters. This implies that parallel data bits are routed among the counter and the individual on-chip pixel ADC registers. The data path bit-width to the pixel is therefore equivalent to the pixel ADC bit resolution.

  2. Converting DYNAMO simulations to Powersim Studio simulations

    Energy Technology Data Exchange (ETDEWEB)

    Walker, La Tonya Nicole; Malczynski, Leonard A.

    2014-02-01

    DYNAMO is a computer program for building and running 'continuous' simulation models. It was developed by the Industrial Dynamics Group at the Massachusetts Institute of Technology for simulating dynamic feedback models of business, economic, and social systems. The history of the system dynamics method since 1957 includes many classic models built in DYANMO. It was not until the late 1980s that software was built to take advantage of the rise of personal computers and graphical user interfaces that DYNAMO was supplanted. There is much learning and insight to be gained from examining the DYANMO models and their accompanying research papers. We believe that it is a worthwhile exercise to convert DYNAMO models to more recent software packages. We have made an attempt to make it easier to turn these models into a more current system dynamics software language, Powersim © Studio produced by Powersim AS2 of Bergen, Norway. This guide shows how to convert DYNAMO syntax into Studio syntax.

  3. Realization of the LEP power converters

    International Nuclear Information System (INIS)

    After a phase of intensive and detailed preparation, which included preliminary inquiries to a wide variety of firms, more than forty contracts and large orders were placed with industry. They cover the power part of the converters for the magnet system, the RF klystrons and the vacuum pumps as well as the electronics for the supervision, control and local intelligence for these high-precision equipments. The first deliveries of the series production started in the second half of 1986 and by the end of 1987 most of the high-power units for the magnet system have been delivered to CERN. After thorough tests they are being installed in the LEP equipment buildings. This includes all the equipment necessary for the injection tests into LEP octant 1 to 2, scheduled for July '88. This paper reports that the tests on the prototype 100 kV, 40 A converter for the RF klystrons were successfully terminated with a full power run on the RF test string. The first sets of the series units are being delivered, tested and installed. An important aspect for obtaining high reliability lies in the automatic test procedures which are rigorously carried out, starting at the module level and ending at the complete equipment

  4. A nanoscale linear-to-linear motion converter of graphene.

    Science.gov (United States)

    Dai, Chunchun; Guo, Zhengrong; Zhang, Hongwei; Chang, Tienchong

    2016-08-14

    Motion conversion plays an irreplaceable role in a variety of machinery. Although many macroscopic motion converters have been widely used, it remains a challenge to convert motion at the nanoscale. Here we propose a nanoscale linear-to-linear motion converter, made of a flake-substrate system of graphene, which can convert the out-of-plane motion of the substrate into the in-plane motion of the flake. The curvature gradient induced van der Waals potential gradient between the flake and the substrate provides the driving force to achieve motion conversion. The proposed motion converter may have general implications for the design of nanomachinery and nanosensors.

  5. Width effects on hydrodynamics of pendulum wave energy converter

    Institute of Scientific and Technical Information of China (English)

    王冬姣; 邱守强; 叶家玮

    2014-01-01

    Based on two- and three-dimensional potential flow theories, the width effects on the hydrodynamics of a bottom-hinged trapezoidal pendulum wave energy converter are discussed. The two-dimensional eigenfunction expansion method is used to obtain the diffraction and radiation solutions when the converter width tends to be infinity. The trapezoidal section of the converter is approximated by a rectangular section for simplification. The nonlinear viscous damping effects are accounted for by including a drag term in the two- and three-dimensional methods. It is found that the three-dimensional results are in good agreement with the two-dimensional results when the converter width becomes larger, especially when the converter width is infinity, which shows that both of the methods are reasonable. Meantime, it is also found that the peak value of the conversion efficiency decreases as the converter width increases in short wave periods while increases when the converter width increases in long wave periods.

  6. Bifurcation behaviours of peak current controlled PFC boost converter

    Institute of Scientific and Technical Information of China (English)

    Ren Hai-Peng; Liu Ding

    2005-01-01

    Bifurcation behaviours of the peak current controlled power-factor-correction (PFC) boost converter, including fast-scale instability and low-frequency bifurcation, are investigated in this paper. Conventionally, the PFC converter is analysed in continuous conduction mode (CCM). This prevents us from recognizing the overall dynamics of the converter. It has been pointed out that the discontinuous conduction mode (DCM) can occur in the PFC boost converter, especially in the light load condition. Therefore, the DCM model is employed to analyse the PFC converter to cover the possible DCM operation. By this way, the low-frequency bifurcation diagram is derived, which makes the route from period-double bifurcation to chaos clear. The bifurcation diagrams versus the load resistance and the output capacitance also indicate the stable operation boundary of the converter, which is useful for converter design.

  7. Converter applications and their influence on large electrical machines

    CERN Document Server

    Drubel, Oliver

    2013-01-01

    Converter driven applications are applied in more and more processes. Almost any installed wind-farm, ship drives, steel mills, several boiler feed water pumps, extruder and many other applications operate much more efficient and economic in case of variable speed solutions. The boundary conditions for a motor or generator will change, if it is supplied by a converter. An electrical machine, which is operated by a converter, can no longer be regarded as an independent component, but is embedded in a system consisting of converter and machine. This book gives an overview of existing converter designs for large electrical machines. Methods for the appropriate calculation of machine phenomena, which are implied by converters are derived in the power range above 500kVA. It is shown how due to the converter inherent higher voltage harmonics and pulse frequencies special phenomena are caused inside the machine which can be the reason for malfunction. It is demonstrated that additional losses create additional tempe...

  8. Pricing Chinese Convertible Bonds with Dynamic Credit Risk

    Directory of Open Access Journals (Sweden)

    Ping Li

    2014-01-01

    Full Text Available To price convertible bonds more precisely, least squares Monte Carlo (LSM method is used in this paper for its advantage in handling the dependence of derivatives on the path, and dynamic credit risk is used to replace the fixed one to make the value of convertible bonds reflect the real credit risk. In the empirical study, we price convertible bonds based on static credit risk and dynamic credit risk, respectively. Empirical results indicate that the ICBC convertible bond has been overpriced, resulting from the underestimation of credit risk. In addition, when there is an issue of dividend, the conversion price will change in China's convertible bonds, while it does not change in the international convertible bonds. So we also empirically study the difference between the convertible bond's prices by assuming whether the conversion price changes or not.

  9. A Low Cost Single-Switch Bridgeless Boost PFC Converter

    Directory of Open Access Journals (Sweden)

    Younghoon Cho

    2014-03-01

    Full Text Available This paper proposes the single-switch bridgeless boost power factor correction (PFC converter to achieve high efficiency in low cost. The proposed converter utilizes only one active switching device for PFC operation as well as expecting higher efficiency than typical boost PFC converters. On the other hand, the implementation cost is less than traditional bridgeless boost PFC converters, in where two active switching deivces are necessary. The operational principle, the modeling, and the control scheme of the proposed converter are discussed in detail. In order to verify the operation of the proposed converter, a 500W switching model is built in PSIM software package. The simulation results show that the proposed converter perfectly achieves PFC operation with only a single active switch.

  10. Affecting Factors and Improving Measures for Converter Gas Recovery

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    To change the undesirable present situation of recovering and using converter gas in steel plants in China,the basic approaches to improving the converter gas recovery rate were analyzed theoretically along with the change curves of the converter gas component content, based on the converter gas recovery system of Baosteel No. 2 steelmaking plant. The effects of converter device, raw material, air imbibed quantity, recovery restricted condition, and intensity of oxygen blowing on the converter gas recovery rate were studied. Among these, the effects of the air imbibed quantity, recovery restricted condition, and intensity of oxygen blowing are remarkable. Comprehensive measures were put forward for improving the converter gas recovery from the point of devices, etc. , and good results were achieved.

  11. Bifurcation behaviours of peak current controlled PFC boost converter

    Science.gov (United States)

    Ren, Hai-Peng; Liu, Ding

    2005-07-01

    Bifurcation behaviours of the peak current controlled power-factor-correction (PFC) boost converter, including fast-scale instability and low-frequency bifurcation, are investigated in this paper. Conventionally, the PFC converter is analysed in continuous conduction mode (CCM). This prevents us from recognizing the overall dynamics of the converter. It has been pointed out that the discontinuous conduction mode (DCM) can occur in the PFC boost converter, especially in the light load condition. Therefore, the DCM model is employed to analyse the PFC converter to cover the possible DCM operation. By this way, the low-frequency bifurcation diagram is derived, which makes the route from period-double bifurcation to chaos clear. The bifurcation diagrams versus the load resistance and the output capacitance also indicate the stable operation boundary of the converter, which is useful for converter design.

  12. Crystal Structure of Pyridoxal Kinase from the Escherichia coli pdxK Gene: Implications for the Classification of Pyridoxal Kinases

    OpenAIRE

    Safo, Martin K.; Musayev, Faik N.; di Salvo, Martino L.; Hunt, Sharyn; Claude, Jean-Baptiste; Schirch, Verne

    2006-01-01

    The pdxK and pdxY genes have been found to code for pyridoxal kinases, enzymes involved in the pyridoxal phosphate salvage pathway. Two pyridoxal kinase structures have recently been published, including Escherichia coli pyridoxal kinase 2 (ePL kinase 2) and sheep pyridoxal kinase, products of the pdxY and pdxK genes, respectively. We now report the crystal structure of E. coli pyridoxal kinase 1 (ePL kinase 1), encoded by a pdxK gene, and an isoform of ePL kinase 2. The structures were deter...

  13. Mitogen-activated protein kinases in atherosclerosis

    Directory of Open Access Journals (Sweden)

    Dorota Bryk

    2014-01-01

    Full Text Available Intracellular signalling cascades, in which MAPK (mitogen-activated protein kinases intermediate, are responsible for a biological response of a cell to an external stimulus. MAP kinases, which include ERK1/2 (extracellular signalling-regulated kinase, JNK (c-Jun N-terminal kinase and p 38 MAPK, regulate the activity of many proteins, enzymes and transcription factors and thus have a wide spectrum of biological effects. Many basic scientific studies have defined numerous details of their pathway organization and activation. There are also more and more studies suggesting that individual MAP kinases probably play an important role in the pathogenesis of atherosclerosis. They may mediate inflammatory processes, endothelial cell activation, monocyte/macrophage recruitment and activation, smooth muscle cell proliferation and T-lymphocyte differentiation, all of which represent crucial mechanisms involved in pathogenesis of atherosclerosis. The specific inhibition of an activity of the respective MAP kinases may prove a new therapeutic approach to attenuate atherosclerotic plaque formation in the future. In this paper, we review the current state of knowledge concerning MAP kinase-dependent cellular and molecular mechanisms underlying atherosclerosis.

  14. Structure and Control of Flywheel Energy Converter

    Directory of Open Access Journals (Sweden)

    Yiming He

    2011-02-01

    Full Text Available On the basis of the flywheel energy converter’s structure in wind power turbine, we have used permanent-magnet synchronism motor as energy converter and built mathematical model. We have studied and realized control method of wind power turbine’s constant output power. By analyzing the mathematical model, we have concluded that the needed time of stored energy is three times longer than constant torque control time, and the needed motor power is one second of constant torque control. When flywheel starts from zero speed to basic speed ([(ω_max/5], the constant torque control method will be acquired. When flywheel speeds up between [(ω_max/5] and ω_max , the amplitude power control will be acquired. What we have studied is very important to realize constant output power.

  15. Clustering of cycloidal wave energy converters

    Science.gov (United States)

    Siegel, Stefan G.

    2016-03-29

    A wave energy conversion system uses a pair of wave energy converters (WECs) on respective active mountings on a floating platform, so that the separation of the WECs from each other or from a central WEC can be actively adjusted according to the wavelength of incident waves. The adjustable separation facilitates operation of the system to cancel reactive forces, which may be generated during wave energy conversion. Modules on which such pairs of WECs are mounted can be assembled with one or more central WECs to form large clusters in which reactive forces and torques can be made to cancel. WECs of different sizes can be employed to facilitate cancelation of reactive forces and torques.

  16. A system for converting print into braille.

    Science.gov (United States)

    Blenkhorn, P

    1997-06-01

    This paper describes a method for converting text into braille, in the form in which it is stored as in a computer. The system has been designed to be configurable for a wide range of languages and character sets, and uses a predominantly table driven method to achieve this. The algorithm is explained in the context of the conversion of text into Standard English Braille (British), and the tables for this transformation are given. Particular importance has been attached to enabling braille specialists, who are not experts in computer algorithms, to be able to modify the system for either slight modifications to an existing braille code translator, or for producing a braille code translator for a new language.

  17. Transcutaneous optical power converter for implantable devices

    Science.gov (United States)

    Tamura, Toshiyo; Shamsuddin, A. K. M.; Kawarada, Atsushi; Togawa, Tatsuo; Oberg, P. Ake

    1994-02-01

    An optical transcutaneous power converter has been developed for the power supply of implanted devices. It consists of a light source, optical fiber system and a photo detector. The light source is either a halogen lamp or continuous high-power laser diode which illuminated skin surface. The light penetrates through the skin to the solar cells. The preliminary experiments with a slice of tissue in between the light source and the solar cells showed that the power transfer efficiency was 40% in comparison to direct illumination of the solar cells. The maximum electric power obtained with a slice of tissue simulating the skin was about 8 mW at a laser diode run at a power of 100 mW. The electric power transferred is enough to supply low power consuming CMOS circuits.

  18. DIGITAL UP CONVERTER FOR WIMAX SYSTEM

    Directory of Open Access Journals (Sweden)

    CHARANJIT SINGH

    2010-09-01

    Full Text Available In the recent times, mobile communication needs not only a high data rate transmission but also a relatively fast mobility. The mobile WiMAX based on orthogonal frequency division multiple access (OFDMA can addresses both of these requirements. To implement the mobile WiMAX (IEEE 802.16e system, one must address a number of key issues in signal processing related to physical layer implementation. Within wireless base station system design, one continues to seek ways to add value and performance while increasing differentiation. In thispaper solution is proposed mainly for the front end, in term of design of Digital Up Converter (DUC which will obey the spectral consideration of WiMAX system (IEEE 802.16. Efficient design of DUC can contribute in the overall efficient system implementation. The DUC is designed for high-speed and high-bandwidth digitalsignal processing applications along with the capability of flexible digital filtering.

  19. Simplifying the circuit of Josephson parametric converters

    Science.gov (United States)

    Abdo, Baleegh; Brink, Markus; Chavez-Garcia, Jose; Keefe, George

    Josephson parametric converters (JPCs) are quantum-limited three-wave mixing devices that can play various important roles in quantum information processing in the microwave domain, including amplification of quantum signals, transduction of quantum information, remote entanglement of qubits, nonreciprocal amplification, and circulation of signals. However, the input-output and biasing circuit of a state-of-the-art JPC consists of bulky components, i.e. two commercial off-chip broadband 180-degree hybrids, four phase-matched short coax cables, and one superconducting magnetic coil. Such bulky hardware significantly hinders the integration of JPCs in scalable quantum computing architectures. In my talk, I will present ideas on how to simplify the JPC circuit and show preliminary experimental results

  20. Mechanical vibration to electrical energy converter

    Science.gov (United States)

    Kellogg, Rick Allen; Brotz, Jay Kristoffer

    2009-03-03

    Electromechanical devices that generate an electrical signal in response to an external source of mechanical vibrations can operate as a sensor of vibrations and as an energy harvester for converting mechanical vibration to electrical energy. The devices incorporate a magnet that is movable through a gap in a ferromagnetic circuit, wherein a coil is wound around a portion of the ferromagnetic circuit. A flexible coupling is used to attach the magnet to a frame for providing alignment of the magnet as it moves or oscillates through the gap in the ferromagnetic circuit. The motion of the magnet can be constrained to occur within a substantially linear range of magnetostatic force that develops due to the motion of the magnet. The devices can have ferromagnetic circuits with multiple arms, an array of magnets having alternating polarity and, encompass micro-electromechanical (MEM) devices.

  1. Converting energy from fusion into useful forms

    CERN Document Server

    Kovari, M; Jenkins, I; Kiely, C

    2014-01-01

    If fusion power reactors are to be feasible, it will still be necessary to convert the energy of the nuclear reaction into usable form. The heat produced will be removed from the reactor core by a primary coolant, which might be water, helium, molten lithium-lead, molten lithium-containing salt, or CO2. The heat could then be transferred to a conventional Rankine cycle or Brayton (gas turbine) cycle. Alternatively it could be used for thermochemical processes such as producing hydrogen or other transport fuels. Fusion presents new problems because of the high energy neutrons released. These affect the selection of materials and the operating temperature, ultimately determining the choice of coolant and working cycle. The limited temperature ranges allowed by present day irradiated structural materials, combined with the large internal power demand of the plant, will limit the overall thermal efficiency. The operating conditions of the fusion power source, the materials, coolant, and energy conversion system w...

  2. Generators for gearless wind energy converters

    Energy Technology Data Exchange (ETDEWEB)

    Grauers, A. [Chalmers Univ. of Technology, Goeteborg (Sweden). Dept. of Electric Power Engineering

    1996-12-01

    This paper discusses some design alternatives for directly driven generators, and one specific generator type is investigated for a wide range of rated power. First, the specification for a directly driven generator is presented, then different design alternatives are discussed. A radial-flux permanent magnet generator for frequency converter connection has been chosen for a more detailed investigation. The design, optimization and performance of that generator type are presented. Generators from 30 kW to 3 MW are designed and compared with conventional four-pole generators with gear. It is found that a directly driven generator can be more efficient than a conventional generator and gear and have a rather small diameter and a low active weight. 8 refs, 7 figs, 2 tabs

  3. Modular Power Converters for PV Applications

    Energy Technology Data Exchange (ETDEWEB)

    Ozpineci, Burak [ORNL; Tolbert, Leon M [ORNL

    2012-05-01

    This report describes technical opportunities to serve as parts of a technological roadmap for Shoals Technologies Group in power electronics for PV applications. There are many different power converter circuits that can be used for solar inverter applications. The present applications do not take advantage of the potential for using common modules. We envision that the development of a power electronics module could enable higher reliability by being durable and flexible. Modules would have fault current limiting features and detection circuits such that they can limit the current through the module from external faults and can identify and isolate internal faults such that the remaining modules can continue to operate with only minimal disturbance to the utility or customer. Development of a reliable, efficient, low-cost, power electronics module will be a key enabling technology for harnessing more power from solar panels and enable plug and play operation. Power electronics for computer power supplies, communication equipment, and transportation have all targeted reliability and modularity as key requirements and have begun concerted efforts to replace monolithic components with collections of common smart modules. This is happening on several levels including (1) device level with intelligent control, (2) functional module level, and (3) system module. This same effort is needed in power electronics for solar applications. Development of modular units will result in standard power electronic converters that will have a lower installed and operating cost for the overall system. These units will lead to increased adaptability and flexibility of solar inverters. Incorporating autonomous fault current limiting and reconfiguration capabilities into the modules and having redundant modules will lead to a durable converter that can withstand the rigors of solar power generation for more than 30 years. Our vision for the technology roadmap is that there is no need

  4. Stable solutions for a catalytic converter

    Energy Technology Data Exchange (ETDEWEB)

    Byrne, H.; Norbury, J. (Univ. of Oxford (United Kingdom). Mathematical Inst.)

    1994-06-01

    A coupled system of partial differential equations that describes the evolution of solid and gas temperatures and gas concentration inside a catalytic converter is derived and examined. The use of a reaction term, which is a discontinuous function of the solid temperature and gas concentration, implies that two types of nontrivial solutions may occur. These are characterized by the manner in which the reaction switches off: either the solid temperature becomes too low (U-solutions) or the gaseous concentration is exhausted (G-solutions). This reaction term differs from the usual combustion term because the reaction is modeled as two-stage, with the large activation-energy limit then justifying the step-function approach adopted. First, steady solutions for which the gas and solid are in thermal equilibrium are studied, and a constraint relating the system's parameters is derived as a necessary condition for the existence of such solutions. Explicit solutions are presented for a particular class of reaction rates, with a linear stability analysis of one case indicating that G-solutions are stable while U-solutions are not. Steady solutions for which the solid and gas are no longer in thermal equilibrium are then considered. For a particular asymptotic limit (and choice of the reaction term), the construction of asymptotic power series expansions shows that the gas temperature exceeds the solid temperature at all points inside the converter. The analysis indicates that separate treatment of the solid and gaseous temperatures has no effect on the qualitative nature of the steady solutions, that is, their existence, stability, and parameter dependence.

  5. The mechanism of protein kinase C regulation

    Institute of Scientific and Technical Information of China (English)

    Julhash U. KAZI

    2011-01-01

    Protein kinase C (PKC) is a family ofserine/threonine protein kinases that plays a central role in transducing extracellular signals into a variety of intracellular responses ranging from cell proliferation to apoptosis.Nine PKC genes have been identified in the human genome,which encode 10 proteins.Each member of this protein kinase family displays distinct biochemical characteristics and is enriched in different cellular and subcellular locations.Activation of PKC has been implicated in the regulation of cell growth and differentiation.This review summarizes works of the past years in the field of PKC biochemistry that covers regulation and activation mechanism of different PKC isoforms.

  6. Differential AMP-activated Protein Kinase (AMPK) Recognition Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase Isoforms.

    Science.gov (United States)

    Fujiwara, Yuya; Kawaguchi, Yoshinori; Fujimoto, Tomohito; Kanayama, Naoki; Magari, Masaki; Tokumitsu, Hiroshi

    2016-06-24

    Ca(2+)/calmodulin-dependent protein kinase kinase β (CaMKKβ) is a known activating kinase for AMP-activated protein kinase (AMPK). In vitro, CaMKKβ phosphorylates Thr(172) in the AMPKα subunit more efficiently than CaMKKα, with a lower Km (∼2 μm) for AMPK, whereas the CaMKIα phosphorylation efficiencies by both CaMKKs are indistinguishable. Here we found that subdomain VIII of CaMKK is involved in the discrimination of AMPK as a native substrate by measuring the activities of various CaMKKα/CaMKKβ chimera mutants. Site-directed mutagenesis analysis revealed that Leu(358) in CaMKKβ/Ile(322) in CaMKKα confer, at least in part, a distinct recognition of AMPK but not of CaMKIα. PMID:27151216

  7. Rac-1 and Raf-1 kinases, components of distinct signaling pathways, activate myotonic dystrophy protein kinase

    Science.gov (United States)

    Shimizu, M.; Wang, W.; Walch, E. T.; Dunne, P. W.; Epstein, H. F.

    2000-01-01

    Myotonic dystrophy protein kinase (DMPK) is a serine-threonine protein kinase encoded by the myotonic dystrophy (DM) locus on human chromosome 19q13.3. It is a close relative of other kinases that interact with members of the Rho family of small GTPases. We show here that the actin cytoskeleton-linked GTPase Rac-1 binds to DMPK, and coexpression of Rac-1 and DMPK activates its transphosphorylation activity in a GTP-sensitive manner. DMPK can also bind Raf-1 kinase, the Ras-activated molecule of the MAP kinase pathway. Purified Raf-1 kinase phosphorylates and activates DMPK. The interaction of DMPK with these distinct signals suggests that it may play a role as a nexus for cross-talk between their respective pathways and may partially explain the remarkable pleiotropy of DM.

  8. Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase.

    OpenAIRE

    Mahajan, S.; Fargnoli, J.; Burkhardt, A L; Kut, S A; Saouaf, S J; Bolen, J B

    1995-01-01

    Bruton's tyrosine kinase (Btk) is tyrosine phosphorylated and enzymatically activated following ligation of the B-cell antigen receptor. These events are temporally regulated, and Btk activation follows that of various members of the Src family of protein tyrosine kinases, thus raising the possibility that Src kinases participate in the Btk activation process. We have evaluated the mechanism underlying Btk enzyme activation and have explored the potential regulatory relationship between Btk a...

  9. The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold*

    Science.gov (United States)

    Gutmann, Sascha; Hinniger, Alexandra; Fendrich, Gabriele; Drückes, Peter; Antz, Sylvie; Mattes, Henri; Möbitz, Henrik; Ofner, Silvio; Schmiedeberg, Niko; Stojanovic, Aleksandar; Rieffel, Sebastien; Strauss, André; Troxler, Thomas; Glatthar, Ralf; Sparrer, Helmut

    2015-01-01

    Macrophages are important cellular effectors in innate immune responses and play a major role in autoimmune diseases such as rheumatoid arthritis. Cancer Osaka thyroid (COT) kinase, also known as mitogen-activated protein kinase kinase kinase 8 (MAP3K8) and tumor progression locus 2 (Tpl-2), is a serine-threonine (ST) kinase and is a key regulator in the production of pro-inflammatory cytokines in macrophages. Due to its pivotal role in immune biology, COT kinase has been identified as an attractive target for pharmaceutical research that is directed at the discovery of orally available, selective, and potent inhibitors for the treatment of autoimmune disorders and cancer. The production of monomeric, recombinant COT kinase has proven to be very difficult, and issues with solubility and stability of the enzyme have hampered the discovery and optimization of potent and selective inhibitors. We developed a protocol for the production of recombinant human COT kinase that yields pure and highly active enzyme in sufficient yields for biochemical and structural studies. The quality of the enzyme allowed us to establish a robust in vitro phosphorylation assay for the efficient biochemical characterization of COT kinase inhibitors and to determine the x-ray co-crystal structures of the COT kinase domain in complex with two ATP-binding site inhibitors. The structures presented in this study reveal two distinct ligand binding modes and a unique kinase domain architecture that has not been observed previously. The structurally versatile active site significantly impacts the design of potent, low molecular weight COT kinase inhibitors. PMID:25918157

  10. Pantothenate kinase-associated neurodegeneration.

    Science.gov (United States)

    Hartig, Monika B; Prokisch, Holger; Meitinger, Thomas; Klopstock, Thomas

    2012-08-01

    Pantothenate kinase-associated neurodegeneration (PKAN) is a hereditary progressive disorder and the most frequent form of neurodegeneration with brain iron accumulation (NBIA). PKAN patients present with a progressive movement disorder, dysarthria, cognitive impairment and retinitis pigmentosa. In magnetic resonance imaging, PKAN patients exhibit the pathognonomic "eye of the tiger" sign in the globus pallidus which corresponds to iron accumulation and gliosis as shown in neuropathological examinations. The discovery of the disease causing mutations in PANK2 has linked the disorder to coenzyme A (CoA) metabolism. PANK2 is the only one out of four PANK genes encoding an isoform which localizes to mitochondria. At least two other NBIA genes (PLA2G6, C19orf12) encode proteins that share with PANK2 a mitochondrial localization and all are suggested to play a role in lipid homeostasis. With no causal therapy available for PKAN until now, only symptomatic treatment is possible. A multi-centre retrospective study with bilateral pallidal deep brain stimulation in patients with NBIA revealed a significant improvement of dystonia. Recently, studies in the PANK Drosophila model "fumble" revealed improvement by the compound pantethine which is hypothesized to feed an alternate CoA biosynthesis pathway. In addition, pilot studies with the iron chelator deferiprone that crosses the blood brain barrier showed a good safety profile and some indication of efficacy. An adequately powered randomized clinical trial will start in 2012. This review summarizes clinical presentation, neuropathology and pathogenesis of PKAN. PMID:22515741

  11. Kinase inhibitors for advanced medullary thyroid carcinoma

    Directory of Open Access Journals (Sweden)

    Martin Schlumberger

    2012-01-01

    Full Text Available The recent availability of molecular targeted therapies leads to a reconsideration of the treatment strategy for patients with distant metastases from medullary thyroid carcinoma. In patients with progressive disease, treatment with kinase inhibitors should be offered.

  12. Genetics Home Reference: deoxyguanosine kinase deficiency

    Science.gov (United States)

    ... or mtDNA, which is essential for the normal function of these structures. Deoxyguanosine kinase is involved in producing and maintaining the ... DNA (known as mitochondrial DNA depletion) impairs mitochondrial function ... deficiency . Learn more about the gene associated ...

  13. Genetics Home Reference: phosphoglycerate kinase deficiency

    Science.gov (United States)

    ... Children Living with Inherited Metabolic Diseases (CLIMB) (UK) Muscular Dystrophy Association National Organization for Rare Disorders (NORD) Resource list from the University of Kansas Medical Center: Metabolic Conditions Genetic Testing Registry (2 links) Deficiency of phosphoglycerate kinase ...

  14. Kinome profiling of Arabidopsis using arrays of kinase consensus substrates

    NARCIS (Netherlands)

    Ritsema, T.; Joore, J.; Workum, W. van; Pieterse, C.M.J.

    2007-01-01

    Background: Kinome profiling aims at the parallel analysis of kinase activities in a cell. Novel developed arrays containing consensus substrates for kinases are used to assess those kinase activities. The arrays described in this paper were already used to determine kinase activities in mammalian s

  15. A Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine Kinases

    Energy Technology Data Exchange (ETDEWEB)

    Chen,H.; Ma, J.; Li, W.; Eliseenkova, A.; Xu, C.; Neubert, T.; Miller, W.; Mohammadi, M.

    2007-01-01

    Activating mutations in the tyrosine kinase domain of receptor tyrosine kinases (RTKs) cause cancer and skeletal disorders. Comparison of the crystal structures of unphosphorylated and phosphorylated wild-type FGFR2 kinase domains with those of seven unphosphorylated pathogenic mutants reveals an autoinhibitory 'molecular brake' mediated by a triad of residues in the kinase hinge region of all FGFRs. Structural analysis shows that many other RTKs, including PDGFRs, VEGFRs, KIT, CSF1R, FLT3, TEK, and TIE, are also subject to regulation by this brake. Pathogenic mutations activate FGFRs and other RTKs by disengaging the brake either directly or indirectly.

  16. Protein kinase domain of twitchin has protein kinase activity and an autoinhibitory region.

    Science.gov (United States)

    Lei, J; Tang, X; Chambers, T C; Pohl, J; Benian, G M

    1994-08-19

    Twitchin is a 753-kDa polypeptide located in the muscle A-bands of the nematode, Caenorhabditis elegans. It consists of multiple copies of both fibronectin III and immunoglobulin C2 domains and, near the C terminus, a protein kinase domain with greatest homology to the catalytic domains of myosin light chain kinases. We have expressed and purified from Escherichia coli twitchin's protein kinase catalytic core and flanking sequences that do not include fibronectin III and immunoglobulin C2 domains. The protein was shown to phosphorylate a model substrate and to undergo autophosphorylation. The autophosphorylation occurs at a slow rate, attaining a maximum at 3 h with a stoichiometry of about 1.0 mol of phosphate/mol of protein, probably through an intramolecular mechanism. Sequence analysis of proteolytically derived phosphopeptides revealed that autophosphorylation occurred N-terminal to the catalytic core, predominantly at Thr-5910, with possible minor sites at Ser5912 and/or Ser-5913. This portion of twitchin (residues 5890-6268) was also phosphorylated in vitro by protein kinase C in the absence of calcium and phosphotidylserine, but not by cAMP-dependent protein kinase. By comparing the activities of three twitchin segments, the enzyme appears to be inhibited by the 60-amino acid residues lying just C-terminal to the kinase catalytic core. Thus, like a number of other protein kinases including myosin light chain kinases, the twitchin kinase appears to be autoregulated. PMID:8063727

  17. Janus kinases in immune cell signaling

    OpenAIRE

    Ghoreschi, Kamran; Laurence, Arian; O’Shea, John J.

    2009-01-01

    The Janus family kinases (Jaks), Jak1, Jak2, Jak3, and Tyk2, form one subgroup of the non-receptor protein tyrosine kinases. They are involved in cell growth, survival, development, and differentiation of a variety of cells but are critically important for immune cells and hematopoietic cells. Data from experimental mice and clinical observations have unraveled multiple signaling events mediated by Jak in innate and adaptive immunity. Deficiency of Jak3 or Tyk2 results in defined clinical dis...

  18. Non-degradative Ubiquitination of Protein Kinases.

    OpenAIRE

    K Aurelia Ball; Johnson, Jeffrey R.; Lewinski, Mary K; John Guatelli; Erik Verschueren; Krogan, Nevan J.; Matthew P Jacobson

    2016-01-01

    Growing evidence supports other regulatory roles for protein ubiquitination in addition to serving as a tag for proteasomal degradation. In contrast to other common post-translational modifications, such as phosphorylation, little is known about how non-degradative ubiquitination modulates protein structure, dynamics, and function. Due to the wealth of knowledge concerning protein kinase structure and regulation, we examined kinase ubiquitination using ubiquitin remnant immunoaffinity enrichm...

  19. Integrated Solar Power Converters: Wafer-Level Sub-Module Integrated DC/DC Converter

    Energy Technology Data Exchange (ETDEWEB)

    None

    2012-02-09

    Solar ADEPT Project: CU-Boulder is developing advanced power conversion components that can be integrated into individual solar panels to improve energy yields. The solar energy that is absorbed and collected by a solar panel is converted into useable energy for the grid through an electronic component called an inverter. Many large, conventional solar energy systems use one, central inverter to convert energy. CU-Boulder is integrating smaller, microinverters into individual solar panels to improve the efficiency of energy collection. The University’s microinverters rely on electrical components that direct energy at high speeds and ensure that minimal energy is lost during the conversion process—improving the overall efficiency of the power conversion process. CU-Boulder is designing its power conversion devices for use on any type of solar panel.

  20. Power Electronics Converters for Variable Speed Pump Storage

    Directory of Open Access Journals (Sweden)

    Othman Hassan Abdalla

    2012-12-01

    Full Text Available This paper proposed the power electronics solution to obtain variable speed of the variable-speed pump storage The study focused on the types of variable-speed pump storage consists of doubly fed asynchronous machine and power electronics converter. Power Electronics converters used in this model are cycloconverter, two levels, three levels voltage source- converter and H-bridge cascaded eleven levels converters. The total harmonic distortions of rotor currents of Doubly fed asychronous machine and speed change for each type of converters are analyzed. Study explained the H-bridge eleven level converter is the best solution than other types.All simulation models depended on the used of PSIM software program.

  1. Symmetry Analysis of Thermoelectric Energy Converters with Inhomogeneous Legs

    Science.gov (United States)

    Korzhuev, M. A.

    2010-09-01

    Symmetry analysis has been applied to thermoelectric energy converters [thermoelectric generators (TEG), coolers (TEC), and heaters (TEH)] with inhomogeneous legs. The features of the crystallographic symmetry of thermoelectric materials and the symmetry of legs, thermocouples, and modules are studied. The effect of symmetry on the figure of merit Z of thermoelectric energy converters is considered. A general rule for proper placement of legs in thermoelectric converters is developed. A modified tetratomic classification for thermoelectric energy converters with inhomogeneous legs (TEGa, TEGb, TEC, and TEH) is proposed. An increase in Z for thermoelectric energy converters with inhomogeneous legs is due to the bulk thermoelectric effect. An increase in Z gives the reduction of irreversible processes in the modules (Joule heating and thermal conductivity), accompanying breaking of the symmetry of the legs. It is found that violations of the symmetry requirements can lead to significant energy losses in converters.

  2. High Voltage Bi-directional Flyback Converter for Capacitive Actuator

    DEFF Research Database (Denmark)

    Thummala, Prasanth; Zhang, Zhe; Andersen, Michael A. E.

    2013-01-01

    This paper presents a high voltage DC-DC converter topology for bi-directional energy transfer between a low voltage DC source and a high voltage capacitive load. The topology is a bi-directional flyback converter with variable switching frequency control during the charge mode, and constant...... switching frequency control during the discharge mode. The converter is capable of charging the capacitive load from 24 V DC source to 2.5 kV, and discharges it to 0 V. The flyback converter has been analyzed in detail during both charge and discharge modes, by considering all the parasitic elements...... in the converter, including the most dominating parameters of the high voltage transformer viz., self-capacitance and leakage inductance. The specific capacitive load for this converter is a dielectric electro active polymer (DEAP) actuator, which can be used as an effective replacement for conventional actuators...

  3. Synchronously Driven Power Converter Controller Solution for MedAustron

    CERN Document Server

    Šepetavc, Luka; Tavčar, Rok; Moser, Roland; Gutleber, Johannes

    2011-01-01

    MedAustron is an ion beam cancer therapy and research centre currently under construction in Wiener Neustadt, Austria. This facility features a synchrotron particle accelerator for light ions. Cosylab is closely working together with MedAustron on the development of a power converter controller (PCC) for the 260 deployed power converters – power supplies. Power converters deliver power to magnets used for focusing and steering particle beams. We have designed and developed software and hardware which allows integration of different types of power converters into MedAustron's control system (MACS). PCC's role is to synchronously control and monitor connected power converters. Custom real-time fibre optics link and modular front end devices have been designed for this purpose. Modular front end devices make it possible to interface with almost any type of power converter – with or without built in regulation logic. We implemented realtime mechanisms and a dedicated real-time fibre link to ...

  4. Closed Loop Control of Soft Switched Interleaved Buck Converter

    Directory of Open Access Journals (Sweden)

    R. Shenbagalakshmi

    2012-06-01

    Full Text Available Design, Modeling and Simulation of a closed loop control is presented for Interleaved Buck Converter with Soft Switching. The features of the closed loop system are to reduce the switching losses and load current sharing among the parallel connected converters. The control system of the converter is designed using PWM technique. In order to improve the transient response and dynamic stability of the converters, the controller parameters are designed based on current mode control. Resonant components thus designed enable the application of zero current switching for both the converters connected in parallel thereby maintaining greater efficiency and minimizing voltage and current oscillations. The system analysis, design and performance are verified through simulation using MATLAB/Simulink environment. The simulation approach reveals the high speed dynamic performance of the closed loop system designed using robust PID controller. The laboratory prototype of the Buck converter is developed to verify the controller platform using PIC16F877A microcontroller.

  5. PERFORMANCE ANALYSIS OF 2D CONVERTER BY COMBINING SR & KY CONVERTERS

    OpenAIRE

    V Manoj Kumar; G.V.S.S.N.S. Sarma

    2014-01-01

    Most of the portable equipments use battery as power source. The increasing use of low voltage portable devices and growing requirements of functionalities embedded into such devices. Thus an efficient power management technique is needed for longer battery life for them. Highly variable nature of batteries systems often require supply voltages to be both higher and lower than the battery. This is most efficiently generated by a buck-boost switching converter. But here the con...

  6. Tyrosine kinase inhibitors in hematological malignancies

    Directory of Open Access Journals (Sweden)

    Kamila Kosior

    2011-12-01

    Full Text Available Recently novel treatment modalities has focused on targeted therapies. Tyrosine kinases represent a good target for cancer treatment since they are involved in transferring phosphate groups from ATP to tyrosine residues in specific substrate proteins transducing intracellular signals engaged in the many mechanisms, playing an important role in the modulation of growth factors signaling that are strongly related to carcinogenesis. Deregulation of tyrosine kinases activity was also found in hematological malignancies, particularly overexpression of tyrosine kinases was observed in chronic myeloid leukemia or acute lymphoblastic leukemia. Herein we show that tyrosine kinase inhibitors have revolutionized hematology malignancies therapy in a very short period of time and they still remain one of the most interesting anticancer compounds that could give a hope for cure and not only long-lasting complete remission. This manuscript summarizes current view on the first generation tyrosine kinase inhibititor – imatinib, second generation – dasatinib, nilotinib and bosutnib as well as new generation tyrosine kinase inhibititors – ponatinib and danusertib in hematooncology.

  7. Fibronectin phosphorylation by ecto-protein kinase

    Energy Technology Data Exchange (ETDEWEB)

    Imada, Sumi; Sugiyama, Yayoi; Imada, Masaru (Meiji Institute of Health Science, Odawara (Japan))

    1988-12-01

    The presence of membrane-associated, extracellular protein kinase (ecto-protein kinase) and its substrate proteins was examined with serum-free cultures of Swiss 3T3 fibroblast. When cells were incubated with ({gamma}-{sup 32})ATP for 10 min at 37{degree}C, four proteins with apparent molecular weights between 150 and 220 kDa were prominently phosphorylated. These proteins were also radiolabeled by lactoperoxidase catalyzed iodination and were sensitive to mild tryptic digestion, suggesting that they localized on the cell surface or in the extracellular matrix. Phosphorylation of extracellular proteins with ({gamma}-{sup 32}P)ATP in intact cell culture is consistent with the existence of ecto-protein kinase. Anti-fibronectin antibody immunoprecipitated one of the phosphoproteins which comigrated with a monomer and a dimer form of fibronectin under reducing and nonreducing conditions of electrophoresis, respectively. The protein had affinity for gelatin as demonstrated by retention with gelatin-conjugated agarose. This protein substrate of ecto-protein kinase was thus concluded to be fibronectin. The sites of phosphorylation by ecto-protein kinase were compared with those of intracellularly phosphorylated fibronectin by the analysis of radiolabeled amino acids and peptides. Ecto-protein kinase phosphorylated fibronectin at serine and threonine residues which were distinct from the sites of intracellular fibronectin phosphorylation.

  8. High-power converters for space applications

    Science.gov (United States)

    Park, J. N.; Cooper, Randy

    1991-01-01

    Phase 1 was a concept definition effort to extend space-type dc/dc converter technology to the megawatt level with a weight of less than 0.1 kg/kW (220 lb./MW). Two system designs were evaluated in Phase 1. Each design operates from a 5 kV stacked fuel cell source and provides a voltage step-up to 100 kV at 10 A for charging capacitors (100 pps at a duty cycle of 17 min on, 17 min off). Both designs use an MCT-based, full-bridge inverter, gaseous hydrogen cooling, and crowbar fault protection. The GE-CRD system uses an advanced high-voltage transformer/rectifier filter is series with a resonant tank circuit, driven by an inverter operating at 20 to 50 kHz. Output voltage is controlled through frequency and phase shift control. Fast transient response and stability is ensured via optimal control. Super-resonant operation employing MCTs provides the advantages of lossless snubbing, no turn-on switching loss, use of medium-speed diodes, and intrinsic current limiting under load-fault conditions. Estimated weight of the GE-CRD system is 88 kg (1.5 cu ft.). Efficiency of 94.4 percent and total system loss is 55.711 kW operating at 1 MW load power. The Maxwell system is based on a resonance transformer approach using a cascade of five LC resonant sections at 100 kHz. The 5 kV bus is converted to a square wave, stepped-up to a 100 kV sine wave by the LC sections, rectified, and filtered. Output voltage is controlled with a special series regulator circuit. Estimated weight of the Maxwell system is 83.8 kg (4.0 cu ft.). Efficiency is 87.2 percent and total system loss is 146.411 kW operating at 1 MW load power.

  9. High-power converters for space applications

    Science.gov (United States)

    Park, J. N.; Cooper, Randy

    1991-06-01

    Phase 1 was a concept definition effort to extend space-type dc/dc converter technology to the megawatt level with a weight of less than 0.1 kg/kW (220 lb./MW). Two system designs were evaluated in Phase 1. Each design operates from a 5 kV stacked fuel cell source and provides a voltage step-up to 100 kV at 10 A for charging capacitors (100 pps at a duty cycle of 17 min on, 17 min off). Both designs use an MCT-based, full-bridge inverter, gaseous hydrogen cooling, and crowbar fault protection. The GE-CRD system uses an advanced high-voltage transformer/rectifier filter is series with a resonant tank circuit, driven by an inverter operating at 20 to 50 kHz. Output voltage is controlled through frequency and phase shift control. Fast transient response and stability is ensured via optimal control. Super-resonant operation employing MCTs provides the advantages of lossless snubbing, no turn-on switching loss, use of medium-speed diodes, and intrinsic current limiting under load-fault conditions. Estimated weight of the GE-CRD system is 88 kg (1.5 cu ft.). Efficiency of 94.4 percent and total system loss is 55.711 kW operating at 1 MW load power. The Maxwell system is based on a resonance transformer approach using a cascade of five LC resonant sections at 100 kHz. The 5 kV bus is converted to a square wave, stepped-up to a 100 kV sine wave by the LC sections, rectified, and filtered. Output voltage is controlled with a special series regulator circuit. Estimated weight of the Maxwell system is 83.8 kg (4.0 cu ft.). Efficiency is 87.2 percent and total system loss is 146.411 kW operating at 1 MW load power.

  10. Grid Connected Solar PV System with SEPIC Converter Compared with Parallel Boost Converter Based MPPT

    Directory of Open Access Journals (Sweden)

    T. Ajith Bosco Raj

    2014-01-01

    Full Text Available The main objective of this work is to study the behaviour of the solar PV systems and model the efficient Grid-connected solar power system. The DC-DC MPPT circuit using chaotic pulse width modulation has been designed to track maximum power from solar PV module. The conversion efficiency of the proposed MPPT system is increased when CPWM is used as a control scheme. This paper also proposes a simplified multilevel (seven level inverter for a grid-connected photovoltaic system. The primary goal of these systems is to increase the energy injected to the grid by keeping track of the maximum power point of the panel, by reducing the switching frequency, and by providing high reliability. The maximum power has been tracked experimentally. It is compared with parallel boost converter. Also this model is based on mathematical equations and is described through an equivalent circuit including a PV source with MPPT, a diode, a series resistor, a shunt resistor, and dual boost converter with active snubber circuit. This model can extract PV power and boost by using dual boost converter with active snubber. By using this method the overall system efficiency is improved thereby reducing the switching losses and cost.

  11. Two phase interleaved buck converter for driving high power LEDs

    OpenAIRE

    Beczkowski, Szymon; Munk-Nielsen, Stig

    2011-01-01

    The goal of this paper is to evaluate an interleaved buck topology for driving high current light-emitting diodes. Low output capacitor value allows the use of non-electrolytic capacitors extending the lifetime of the converter. Converter is operated as a constant, regulated current source which increases luminous efficacy of LED compared to PWM dimmed system. Because of the low dynamic resistance of LEDs the duty cycle of the converter does not change greatly with controlled current. By sett...

  12. Operation and maintenance strategies for wave energy converters

    DEFF Research Database (Denmark)

    Ambühl, Simon; Marquis, Laurent; Kofoed, Jens Peter;

    2015-01-01

    and maintenance costs estimations for wave energy converter applications including real weather data and damage accumulation. Furthermore, uncertainties related with costs, structural damage accumulation, inspection accuracy and different maintenance strategies can be included. This article contains a case study......Inspection and maintenance costs are a significant contributor to the cost of energy for wave energy converters. There are different operation and maintenance strategies for wave energy converters. Maintenance can be performed after failure (corrective) or before a breakdown (preventive) occurs...

  13. Changes of Plasma Angiotensin-Converting Enzyme Activity during Hemodialysis *

    OpenAIRE

    Koo, Wan Suh; Lee, Yong Joon; Kim, Hye Su; Kim, Suk Young; Choi, Euy Jin; Chang, Yoon Sik; Yoon, Young Suk; Bang, Byung Kee

    1987-01-01

    Plasma angiotensin-converting enzyme activity was measured by spectrophotometer in normal subjects and in patients with end stage renal failure, serially during a routine hemodialysis. Patients on maintenance hemodialysis tended to be associated with elevated plasma angiotensin-converting enzyme activity versus normal subjects. Plasma angiotensin-converting enzyme activity was significantly elevated in patients with chronic renal failure after 5 hours of hemodialysis(p

  14. A novel soft-switching double modulation converter (DMC)

    OpenAIRE

    Poon, FNK; Ho, WC; Pong, MH

    1995-01-01

    This paper introduces a new and simple power converter topology by which both the amplitude and the duty cycle are modulated to achieve soft switching characteristic in a standard half bridge configuration. This novel double modulation power converter (DMC) is able to provide zero voltage switching and nonpulsating input ripple current. Constant switching frequency, simple control and gate drive circuit makes the DMC an ideal power converter to fill the low to medium power application gap in ...

  15. Modeling and Control of Single Switch Bridgeless SEPIC PFC Converter

    OpenAIRE

    Koh, Hyunsoo

    2012-01-01

    Due to increasing concerns on the power quality, power factor correction (PFC) has become an important issue in light-emitting diode (LED) lighting applications. A boost converter is one of the most well-known PFC topologies, due to its simple circuitry, simple control scheme and small number of passive components. Even though a boost converter is recognized as a typical PFC converter, its output voltage must be higher than its input voltage. This feature is disadvantageous because the dev...

  16. Conducted EMI Evaluation and Reduction in a Forward Switching Converter

    OpenAIRE

    Mohammad Rouhollah Yazdani; Nahid Amini Filabadi

    2012-01-01

    In switching power converters, electromagnetic interference (EMI) is produced due to the fast changes of the voltage and current. Among switching topologies used in low and medium powers, forward converter is vastly employed which needs resetting transformer core. In this paper, a forward converter with reset winding is modeled to predict conducted EMI. To evaluate the EMI model, EMI measurement results are presented. To select an optimum reset scheme from EMI viewpoint, three reset technique...

  17. Research on Matrix Converter Based on Space Vector Modulation

    OpenAIRE

    Zhanjun Qiao; Wei Xu

    2013-01-01

    In this study, we study the control strategy for matrix converter. Through absorbing ideas about virtual rectification put forward by P.D.Ziogas, the common control idea of AC-DC-AC convertor is introduced into control of matrix converter; SPWM modulation strategy and space vector modulation strategy for matrix converter are studied respectively. In terms of SPWM modulation strategy, it has some advantages: for example, main circuit structure is simple; control program is simple; control swit...

  18. Isolated Boost Converter with Bidirectional Operation for Supercapacitor Applications

    DEFF Research Database (Denmark)

    Hernandez Botella, Juan Carlos; Mira Albert, Maria del Carmen; Sen, Gökhan;

    2013-01-01

    This paper presents an isolated bidirectional dc/dc converter based on primary parallel isolated boost converter (PPIBC). This topology is an efficient solution in low voltage high power applications due to its ability to handle high currents in the low voltage side. In this paper, the converter...... interconnecting two battery banks. A second prototype has been constructed and tested for supercapacitor operation in constant power charge mode....

  19. Two phase interleaved buck converter for driving high power LEDs

    DEFF Research Database (Denmark)

    Beczkowski, Szymon; Munk-Nielsen, Stig

    2011-01-01

    increases luminous efficacy of LED compared to PWM dimmed system. Because of the low dynamic resistance of LEDs the duty cycle of the converter does not change greatly with controlled current. By setting the input voltage of the buck converter to around twice the voltage of diode strings, converter can...... be operated close to the 50% duty cycle, where the ripple attenuation is the highest....

  20. Structural basis for substrate specificities of cellular deoxyribonucleoside kinases

    DEFF Research Database (Denmark)

    Johansson, K.; Ramaswamy, S.; Ljungcrantz, C.;

    2001-01-01

    kinase with ATP at the nucleoside substrate binding site. Compared to the human kinase, the Drosophila kinase has a wider substrate cleft, which may be responsible for the broad substrate specificity of this enzyme. The human deoxyguanosine kinase is highly specific for purine substrates......; this is apparently due to the presence of Arg 118, which provides favorable hydrogen bonding interactions with the substrate. The two new structures provide an explanation for the substrate specificity of cellular deoxyribonucleoside kinases....

  1. Evolutionary Reconstruction and Population Genetics Analysis of Aurora Kinases

    OpenAIRE

    Balu Kamaraj; Ambuj Kumar; Rituraj Purohit

    2013-01-01

    BACKGROUND: Aurora kinases belong to the highly conserved kinase family and play a vital role in cell cycle regulation. The structure and function of these kinases are inter-related and sometimes they also act as substitutes in case of knockdown of other aurora kinases. METHOD: In this work we carried out the evolutionary reconstruction and population genetic studies of aurora kinase proteins. Substitution saturation test, CAI (Codon adaptation index), gene expression and RSCU (Relative synon...

  2. ZVZCS PWM DC-DC Converter with Energy Recovery Clamp

    Directory of Open Access Journals (Sweden)

    Vladimir Ruscin

    2008-01-01

    Full Text Available This paper presents research motivated by industrial demand for special traction drive topology devoted tominimization of traction transformer weight against topology with classical 50Hz traction transformer. The special tractiondrive topology for AC power systems consists of input high voltage trolley converter (single phase matrix converter –middle frequency transformer – output converter - traction motor has been described. The main attention has been given tothe control algorithm of the traction topology (inserting of NULL vector of matrix converter and Two-value control ofsecondary active rectifier.

  3. Number-to-voltage converter on commutated condensers

    International Nuclear Information System (INIS)

    A code-voltage converter using precision voltage dividers based on commutated capacitors [1] is described which is distinguished by the absence of precision elements. Each digit includes eight field-effect transistors in two 1KT682 microcircuit assemblies and three microcapacitors with a conventional unstable capacitance 6200 pF +- 50%. The converter has a speed of response that is not inferior to that of converters based on R-2R matrices, while in time stability of the characteristics, low interference level, and low output impedance it is superior to such converters

  4. Integrating data converters for picoampere currents from electrochemical transducers

    OpenAIRE

    Breten, Madalina; Lehmann, Torsten; Bruun, Erik

    2000-01-01

    This paper describes a current mode A/D converter designed for a maximum input current range of 5 nA and a resolution of the order of 1 pA. The converter is designed for a potentiostat for amperometric chemical sensors and provides a constant polarization voltage for the measuring electrode. A prototype chip using the dual slope conversion method has been fabricated in a 0.7 μm CMOS process. Experimental results from this converter are reported. Design problems and limitations of the converte...

  5. LARGE SIGNAL DISCRETE-TIME MODEL FOR PARALLELED BUCK CONVERTERS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    As a number of switch-combinations are involved in operation of multi-converter-system, conventional methods for obtaining discrete-time large signal model of these converter systems result in a very complex solution. A simple sampled-data technique for modeling distributed dc-dc PWM converters system (DCS) was proposed. The resulting model is nonlinear and can be linearized for analysis and design of DCS. These models are also suitable for fast simulation of these networks. As the input and output of dc-dc converters are slow varying, suitable model for DCS was obtained in terms of the finite order input/output approximation.

  6. Integrating data converters for picoampere currents from electrochemical transducers

    DEFF Research Database (Denmark)

    Breten, Madalina; Lehmann, Torsten; Bruun, Erik

    2000-01-01

    This paper describes a current mode A/D converter designed for a maximum input current range of 5 nA and a resolution of the order of 1 pA. The converter is designed for a potentiostat for amperometric chemical sensors and provides a constant polarization voltage for the measuring electrode....... A prototype chip using the dual slope conversion method has been fabricated in a 0.7 μm CMOS process. Experimental results from this converter are reported. Design problems and limitations of the converter are discussed and a new conversion technique providing a larger dynamic range and easy calibration...

  7. Design of a High Efficiency Boost DC-DC Converter

    Institute of Scientific and Technical Information of China (English)

    GAO Jing; YAO Suying; XU Jiangtao; SHI Zaifeng

    2009-01-01

    An accurate circuit of PWM/PFM mode converting and a circuit of auto-adaptively adjusting dimension of power transistor are described. The duty cycle of the signal when the control mode converts can be gained accu-rately by using ratios of currents and capacitances, and an optimal dimension of power transistor is derived with different loads. The converter is designed by 0.35 μm standard CMOS technology. Simulation results indicate that the converter starts work at 0.8 V input voltage. Combined with synchronized rectification, the transfer efficiency is higher than 90% with full load range, and achieves 97.5% at rating output.

  8. Radiated electromagnetic emissions of DC-DC converters

    CERN Document Server

    Sammet, Jan Domenik

    2010-01-01

    A new powering scheme is considered to be mandatory for the CMS tracker at SLHC. The baseline solution of CMS foresees the use of DC-DC converters, allowing to provide larger currents while reducing losses. An important component of most converters are inductors, which, however, tend to radiate the switching noise generated by the converter. The radiated emissions of several converters have been measured and simulated. In addition noise susceptibility measurements with radiated noise and present CMS hardware have been performed. A summary of the results will be presented.

  9. Distributed Generation using Indirect Matrix Converter in Boost Operating Mode

    DEFF Research Database (Denmark)

    Liu, Xiong; Loh, Poh Chiang; Wang, Peng;

    2011-01-01

    Indirect matrix converter (IMC) using two stages configuration is an interesting alternative for ac/ac conversions. In some cases, the ac/ac converter needs boost function, which can't be achieved by traditional IMC due to its limited input-to-output voltage transfer gain 0.866. Alternatively...... power factor and controllable grid-side power factor. In isolated mode, the matrix converter is controlled to supply a three-phase ac voltage and also guarantee sinusoidal input/output waveforms as well as unity input power factor. Simulation and experimental results are provided to validate...... the effectiveness of the control schemes for the proposed matrix converter....

  10. A Three-Phase Interleaved Floating Output Boost Converter

    OpenAIRE

    Ajmal Farooq; Zeeshan Malik; Dongchang Qu; Zhaohui Sun; Guozhu Chen

    2015-01-01

    High step-up dc-dc converter is an essential part in several renewable energy systems. In this paper, a new topology of step-up dc-dc converter based on interleaved structure is proposed. The proposed converter uses three energy storing capacitors to achieve a high voltage gain. Besides the high voltage gain feature, the proposed converter also reduces the voltage stress across the semiconductor switches. This helps in using low rating switching devices which can reduce the overall size and c...

  11. Another look at Statics and Dynamics of Switching Power Converters

    Science.gov (United States)

    Sasaki, Seigo; Watanabe, Haruo

    Three types of switching power supply, which are buck, boost, buck/boost converter, are statically and dynamically analysed. A framework of large signal analysis presents characteristics of converters which vary with operating points, and discusses a relationship between statics and dynamics. It is shown that boost and buck/boost converters substantially change their characteristics. There exists the operating points where for low frequencies the phases become -90° or -180° and the gains fall off to low values. The phenomenon is characterized by a zero of transfer function of the converter and also by the statics.

  12. Hybrid Voltage-Multipliers Based Switching Power Converters

    Science.gov (United States)

    Rosas-Caro, Julio C.; Mayo-Maldonado, Jonathan C.; Vazquez-Bautista, Rene Fabian; Valderrabano-Gonzalez, Antonio; Salas-Cabrera, Ruben; Valdez-Resendiz, Jesus Elias

    2011-08-01

    This work presents a derivation of PWM DC-DC hybrid converters by combining traditional converters with the Cockcroft-Walton voltage multiplier, the voltage multiplier of each converter is driven with the same transistor of the basic topology; this fact makes the structure of the new converters very simple and provides high-voltage gain. The traditional topologies discussed are the boost, buck-boost, Cuk and SEPIC. They main features of the discussed family are: (i) high-voltage gain without using extreme duty cycles or transformers, which allow high switching frequency and (ii) low voltage stress in switching devices, along with modular structures, and more output levels can be added without modifying the main circuit, which is highly desirable in some applications such as renewable energy generation systems. It is shown how a multiplier converter can become a generalized topology and how some of the traditional converters and several state-of-the-art converters can be derived from the generalized topologies and vice-versa. All the discussed converters were simulated, additionally experimental results are provided with an interleaved multiplier converter.

  13. Quantum Dot Spectrum Converters for Enhanced High Efficiency Photovoltaics Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This research proposes to enhance solar cell efficiency, radiation resistance and affordability. The Quantum Dot Spectrum Converter (QDSC) disperses quantum dots...

  14. High Efficiency Hall Thruster Discharge Power Converter Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Busek leveraged previous, internally sponsored, high power, Hall thruster discharge converter development which allowed it to design, build, and test new printed...

  15. Analysis and Design of Embedded Controlled Parallel Resonant Converter

    Directory of Open Access Journals (Sweden)

    P. CHANDRASEKHAR

    2009-07-01

    Full Text Available Microcontroller based constant frequency controlled full bridge LC parallel resonant converter is presented in this paper for electrolyser application. An electrolyser is a part of renewable energy system which generates hydrogen from water electrolysis. The DC power required by the electrolyser system is supplied by the DC-DC converter. Owing to operation under constant frequency, the filter designs are simplified and utilization of magnetic components is improved. This converter has advantages like high power density, low EMI and reduced switching stresses. DC-DC converter system is simulated using MATLAB, Simulink. Detailed simulation results are presented. The simulation results are compared with the experimental results.

  16. Converting ICD-9 to ICD-10.

    Science.gov (United States)

    Stephens, James H; Ledlow, Gerald R; Fockler, Thomas V

    2016-01-01

    Implementing the International Classification of Diseases, Ninth Revision (ICD-9) to International Classification of Diseases, Tenth Revision (ICD-10) conversion on October 1, 2015, in the United States has been a long-term goal. While most countries in the world converted more than 10 years ago, the United States was still using ICD-9. Many countries in the world have a single-payer healthcare system, while there are thousands of different healthcare organizations (providers and payers) that presently exist in the United States. With so many different software platforms for healthcare providers and payers, the conversion had become that much more complicated and capital intensive for all healthcare organizations in the country. A few of the present delay reasons to the ICD-10 conversion in past years were the concurrent timelines for meeting meaningful use requirements for the electronic health record, testing with external payers and upgrades from vendors which added complexities and extra costs. The authors examine the reasoning behind the conversion as well as the delays, before making the conversion on October 1, 2015, and review the question regarding whether the government's decision to push the date back a year would have been helpful. PMID:26980201

  17. Effective plasmonic mode-size converter.

    Science.gov (United States)

    Park, Hae-Ryeong; Park, Jong-Moon; Kim, Min-su; Ju, Jung Jin; Son, Jung-Han; Lee, Myung-Hyun

    2011-10-24

    Plasmonic mode-size converters (PMSCs) for long-range surface plasmon polaritons (LR-SPPs) at the wavelength of 1.55 μm are presented. The PMSC is composed of an insulator-metal-insulator waveguide (IMI-W), a laterally tapered insulator-metal-insulator-metal-insulator waveguide (LT-IMIMI-W), and an IMIMI-W in series. The mode-intensity sizes of the LR-SPPs for the IMI-W and the IMIMI-W were not only calculated using a finite element method but were also experimentally measured. The propagation losses of the IMI-W and the IMIMI-W as well as the coupling losses between them were analyzed by the cut-back method to investigate the effect of LT-IMIMI-Ws. By using the PMSC with a ~27 ° angled LT-IMIMI-W, the coupling loss between a polarization-maintaining fiber and a 3 μm-wide IMIMI-W was reduced by ~3.4 dB. Moreover, the resulting mode-intensity in the output of the PMSC was squeezed to ~35% of the mode-intensity in the input IMI-W. The PMSC may be potentially useful for bridging micro- to nano-plasmonic integrated circuits. PMID:22109009

  18. Converting a Display Screen into a Touchscreen

    Institute of Scientific and Technical Information of China (English)

    Qun Wang; Jun Cheng; San-Ming Shen; Yi-Jiang Shen; Jian-Xin Pang

    2014-01-01

    A method is presented to convert any display screen into a touchscreen by using a pair of cameras. Most state of art touchscreens make use of special touch-sensitive hardware or depend on infrared sensors in various configurations. We describe a novel computer-vision-based method that can robustly identify fingertips and detect touch with a precision of a few millimeters above the screen. In our system, the two cameras capture the display screen image simultaneously. Users can interact with a computer by the fingertip on the display screen. We have two important contributions:first, we develop a simple and robust hand detection method based on predicted images. Second, we determine whether a physical touch takes places by the homography of the two cameras. In this system, the appearance of the display screen in camera images is inherently predictable from the computer output images. Therefore, we can compute the predicted images and extract human hand precisely by simply subtracting the predicted images from captured images.

  19. Novel Modulation Method for Multidirectional Matrix Converter

    Directory of Open Access Journals (Sweden)

    Saman Toosi

    2014-01-01

    Full Text Available This study presents a new modulation method for multidirectional matrix converter (MDMC, based on the direct duty ratio pulse width modulation (DDPWM. In this study, a new structure of MDMC has been proposed to control the power flow direction through the stand-alone battery based system and hybrid vehicle. The modulation method acts based on the average voltage over one switching period concept. Therefore, in order to determine the duty ratio for each switch, the instantaneous input voltages are captured and compared with triangular waveform continuously. By selecting the proper switching pattern and changing the slope of the carriers, the sinusoidal input current can be synthesized with high power factor and desired output voltage. The proposed system increases the discharging time of the battery by injecting the power to the system from the generator and battery at the same time. Thus, it makes the battery life longer and saves more energy. This paper also derived necessary equation for proposed modulation method as well as detail of analysis and modulation algorithm. The theoretical and modulation concepts presented have been verified in MATLAB simulation.

  20. [Angiotensin converting enzyme and Alzheimer's disease].

    Science.gov (United States)

    Kugaevskaia, E V

    2013-01-01

    Alzheimer's disease (AD) is an incurable degenerative disease of the central nervous system, leading to dementia. The basis of AD is neurodegenerative process that leads to death of neurons in the cerebral cortex. This neurodegenerative process is associated with the formation of neurofibrillary tangles in the brain and the deposition of senile plaques, the main component of which is a beta-amyloid peptide (Abeta). Risk factors for AD are age, as well as hypertension, atherosclerosis, diabetes and hypercholesterolemia in the pathogenesis of which involved angiotensin converting enzyme (ACE)--key enzyme of the renin-angiotensin (RAS) and kallikrein-kinin (KKS) systems. Recently it was discovered that ACE, along with other metallopeptidases, participates in the metabolism of Abeta, cleaving the bonds at the N-terminal and C-terminal region of the molecule Abeta. The role of the ACE in the degradation processes of Abeta takes an interest. It is associated with the fact that the using of ACE inhibitors is the main therapeutic approach used in the treatment of various forms of hypertension and other cardiovascular diseases. However, until now not been resolved, can be used antihypertensive drugs that inhibit RAS for the treatment or prevention of AD. Currently, there are numerous studies on finding the relationship between RAS and AD. PMID:23650720

  1. Optimization of Aperiodic Waveguide Mode Converters

    Energy Technology Data Exchange (ETDEWEB)

    Burke, G J; White, D A; Thompson, C A

    2004-12-09

    Previous studies by Haq, Webb and others have demonstrated the design of aperiodic waveguide structures to act as filters and mode converters. These aperiodic structures have been shown to yield high efficiency mode conversion or filtering in lengths considerably shorter than structures using gradual transitions and periodic perturbations. The design method developed by Haq and others has used mode-matching models for the irregular, stepped waveguides coupled with computer optimization to achieve the design goal using a Matlab optimization routine. Similar designs are described here, using a mode matching code written in Fortran and with optimization accomplished with the downhill simplex method with simulated annealing using an algorithm from the book Numerical Recipes in Fortran. Where Haq et al. looked mainly for waveguide shapes with relatively wide cavities, we have sought lower profile designs. It is found that lower profiles can meet the design goals and result in a structure with lower Q. In any case, there appear to be very many possible configurations for a given mode conversion goal, to the point that it is unlikely to find the same design twice. Tolerance analysis was carried out for the designs to show edge sensitivity and Monte Carlo degradation rate. The mode matching code and mode conversion designs were validated by comparison with FDTD solutions for the discontinuous waveguides.

  2. Novel modulation method for multidirectional matrix converter.

    Science.gov (United States)

    Toosi, Saman; Misron, Norhisam; Hanamoto, Tsuyoshi; Bin Aris, Ishak; Radzi, Mohd Amran Mohd; Yamada, Hiroaki

    2014-01-01

    This study presents a new modulation method for multidirectional matrix converter (MDMC), based on the direct duty ratio pulse width modulation (DDPWM). In this study, a new structure of MDMC has been proposed to control the power flow direction through the stand-alone battery based system and hybrid vehicle. The modulation method acts based on the average voltage over one switching period concept. Therefore, in order to determine the duty ratio for each switch, the instantaneous input voltages are captured and compared with triangular waveform continuously. By selecting the proper switching pattern and changing the slope of the carriers, the sinusoidal input current can be synthesized with high power factor and desired output voltage. The proposed system increases the discharging time of the battery by injecting the power to the system from the generator and battery at the same time. Thus, it makes the battery life longer and saves more energy. This paper also derived necessary equation for proposed modulation method as well as detail of analysis and modulation algorithm. The theoretical and modulation concepts presented have been verified in MATLAB simulation. PMID:25298969

  3. Development of a wind converter and investigation of its operational function. Part 1: Technical description of the wind energy converter

    Science.gov (United States)

    Molly, J. P.; Steinheber, R.

    1982-11-01

    A 10 kW wind energy converter was developed by using as far possible standard serial production parts. The design criteria and the description of the essential machinery components of the MODA 10 wind energy converter are discussed. For some special load cases the safety calculation of the important components is shown. The blade control system which qualified for small wind energy converters, is explained. Weight and cost of the MODA 10 are considered.

  4. Non-degradative Ubiquitination of Protein Kinases.

    Directory of Open Access Journals (Sweden)

    K Aurelia Ball

    2016-06-01

    Full Text Available Growing evidence supports other regulatory roles for protein ubiquitination in addition to serving as a tag for proteasomal degradation. In contrast to other common post-translational modifications, such as phosphorylation, little is known about how non-degradative ubiquitination modulates protein structure, dynamics, and function. Due to the wealth of knowledge concerning protein kinase structure and regulation, we examined kinase ubiquitination using ubiquitin remnant immunoaffinity enrichment and quantitative mass spectrometry to identify ubiquitinated kinases and the sites of ubiquitination in Jurkat and HEK293 cells. We find that, unlike phosphorylation, ubiquitination most commonly occurs in structured domains, and on the kinase domain, ubiquitination is concentrated in regions known to be important for regulating activity. We hypothesized that ubiquitination, like other post-translational modifications, may alter the conformational equilibrium of the modified protein. We chose one human kinase, ZAP-70, to simulate using molecular dynamics with and without a monoubiquitin modification. In Jurkat cells, ZAP-70 is ubiquitinated at several sites that are not sensitive to proteasome inhibition and thus may have other regulatory roles. Our simulations show that ubiquitination influences the conformational ensemble of ZAP-70 in a site-dependent manner. When monoubiquitinated at K377, near the C-helix, the active conformation of the ZAP-70 C-helix is disrupted. In contrast, when monoubiquitinated at K476, near the kinase hinge region, an active-like ZAP-70 C-helix conformation is stabilized. These results lead to testable hypotheses that ubiquitination directly modulates kinase activity, and that ubiquitination is likely to alter structure, dynamics, and function in other protein classes as well.

  5. Crystal structure of Cryptosporidium parvum pyruvate kinase.

    Directory of Open Access Journals (Sweden)

    William J Cook

    Full Text Available Pyruvate kinase plays a critical role in cellular metabolism of glucose by serving as a major regulator of glycolysis. This tetrameric enzyme is allosterically regulated by different effector molecules, mainly phosphosugars. In response to binding of effector molecules and substrates, significant structural changes have been identified in various pyruvate kinase structures. Pyruvate kinase of Cryptosporidium parvum is exceptional among known enzymes of protozoan origin in that it exhibits no allosteric property in the presence of commonly known effector molecules. The crystal structure of pyruvate kinase from C. parvum has been solved by molecular replacement techniques and refined to 2.5 Å resolution. In the active site a glycerol molecule is located near the γ-phosphate site of ATP, and the protein structure displays a partially closed active site. However, unlike other structures where the active site is closed, the α6' helix in C. parvum pyruvate kinase unwinds and assumes an extended conformation. In the crystal structure a sulfate ion is found at a site that is occupied by a phosphate of the effector molecule in many pyruvate kinase structures. A new feature of the C. parvum pyruvate kinase structure is the presence of a disulfide bond cross-linking the two monomers in the asymmetric unit. The disulfide bond is formed between cysteine residue 26 in the short N-helix of one monomer with cysteine residue 312 in a long helix (residues 303-320 of the second monomer at the interface of these monomers. Both cysteine residues are unique to C. parvum, and the disulfide bond remained intact in a reduced environment. However, the significance of this bond, if any, remains unknown at this time.

  6. Non-degradative Ubiquitination of Protein Kinases.

    Science.gov (United States)

    Ball, K Aurelia; Johnson, Jeffrey R; Lewinski, Mary K; Guatelli, John; Verschueren, Erik; Krogan, Nevan J; Jacobson, Matthew P

    2016-06-01

    Growing evidence supports other regulatory roles for protein ubiquitination in addition to serving as a tag for proteasomal degradation. In contrast to other common post-translational modifications, such as phosphorylation, little is known about how non-degradative ubiquitination modulates protein structure, dynamics, and function. Due to the wealth of knowledge concerning protein kinase structure and regulation, we examined kinase ubiquitination using ubiquitin remnant immunoaffinity enrichment and quantitative mass spectrometry to identify ubiquitinated kinases and the sites of ubiquitination in Jurkat and HEK293 cells. We find that, unlike phosphorylation, ubiquitination most commonly occurs in structured domains, and on the kinase domain, ubiquitination is concentrated in regions known to be important for regulating activity. We hypothesized that ubiquitination, like other post-translational modifications, may alter the conformational equilibrium of the modified protein. We chose one human kinase, ZAP-70, to simulate using molecular dynamics with and without a monoubiquitin modification. In Jurkat cells, ZAP-70 is ubiquitinated at several sites that are not sensitive to proteasome inhibition and thus may have other regulatory roles. Our simulations show that ubiquitination influences the conformational ensemble of ZAP-70 in a site-dependent manner. When monoubiquitinated at K377, near the C-helix, the active conformation of the ZAP-70 C-helix is disrupted. In contrast, when monoubiquitinated at K476, near the kinase hinge region, an active-like ZAP-70 C-helix conformation is stabilized. These results lead to testable hypotheses that ubiquitination directly modulates kinase activity, and that ubiquitination is likely to alter structure, dynamics, and function in other protein classes as well.

  7. Simulation and Implementation of Quasi Resonant DC-DC Converter

    Directory of Open Access Journals (Sweden)

    N. Devarajan

    2012-01-01

    Full Text Available Problem statement: A half-bridge LLC resonant converter with a voltage doubler rectifier has a simple structure and its Zero-Voltage-Switching (ZVS capability is excellent from zero to full load condition. But conduction loss is more due to high circulating energy thus reducing the system efficiency. Moreover a variable frequency control method makes the control circuits more complicated than those using the Pulse Width Modulation (PWM control method. Thus, DC drive has lower efficiency when it operates on light loads. Approach: To improve the efficiency of the DC drive under light loads, a PWM-controlled quasi-resonant converter is proposed .It has simple control circuits and less conduction loss compared to a half-bridge LLC resonant converter under light load conditions. The proposed converter has a half-bridge LLC resonant converter along with an auxiliary circuit. The load regulation of the proposed converter can be achieved by an auxiliary circuit. Thus the proposed converter is expected to be suitable sustaining power module for the efficiency enhancement of DC drives. As the magnetizing inductance of the proposed converter is larger the circulating energy is considerably reduced under light load conditions. In this study the operational principle, design and modeling of QRC DC-DC converters for DC drives are presented. The PWM controlled quasi resonant converter is implemented using PIC microcontroller 16F184A. Results: The capacitor filter in the output is replaced by pi filter to produce DC with minimum ripple. The experimental results and simulation results are compared. This converter has the advantages like reduced number of switches, reduced transformer and filter size, reduced ripple, reduced switching losses, reduced switching stresses and increased power density. Conclusion: The experimental results closely agree with the simulation results.

  8. Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase.

    Science.gov (United States)

    Mahajan, S; Fargnoli, J; Burkhardt, A L; Kut, S A; Saouaf, S J; Bolen, J B

    1995-10-01

    Bruton's tyrosine kinase (Btk) is tyrosine phosphorylated and enzymatically activated following ligation of the B-cell antigen receptor. These events are temporally regulated, and Btk activation follows that of various members of the Src family of protein tyrosine kinases, thus raising the possibility that Src kinases participate in the Btk activation process. We have evaluated the mechanism underlying Btk enzyme activation and have explored the potential regulatory relationship between Btk and Src protein kinases. We demonstrate in COS transient-expression assays that Btk can be activated through intramolecular autophosphorylation at tyrosine 551 and that Btk autophosphorylation is required for Btk catalytic functions. Coexpression of Btk with members of the Src family of protein tyrosine kinases, but not Syk, led to Btk tyrosine phosphorylation and activation. Using a series of point mutations in Blk (a representative Src protein kinase) and Btk, we show that Src kinases activate Btk through an indirect mechanism that requires membrane association of the Src enzymes as well as functional Btk SH3 and SH2 domains. Our results are compatible with the idea that Src protein tyrosine kinases contribute to Btk activation by indirectly stimulating Btk intramolecular autophosphorylation. PMID:7565679

  9. Phospho-kinase profile of colorectal tumors guides in the selection of multi-kinase inhibitors.

    Science.gov (United States)

    Serrano-Heras, Gemma; Cuenca-López, María Dolores; Montero, Juan Carlos; Corrales-Sanchez, Verónica; Morales, Jorge Carlos; Núñez, Luz-Elena; Morís, Francisco; Pandiella, Atanasio; Ocaña, Alberto

    2015-10-13

    Protein kinases play a central role in the oncogenesis of colorectal tumors and are attractive druggable targets. Detection of activated kinases within a tumor could open avenues for drug selection and optimization of new kinase inhibitors. By using a phosphokinase arrays with human colorectal tumors we identified activated kinases, including the Epidermal Growth Factor Receptor (EGFR), components of the PI3K/mTOR pathway (AKT and S6), and STAT, among others. A pharmacological screening with kinase inhibitors against these proteins helped us to identify a new kinase inhibitor, termed EC-70124 that showed the highest anti-proliferative activity in cell lines. EC-70124 also inhibited cell migration and biochemical experiments demonstrated its effect targeting the PI3K/mTOR pathway. This drug also arrested cells at G2/M and induced apoptosis. Experiments in combination with standard chemotherapy used in the clinical setting indicated a synergistic effect. EC-70124 also reduced tumor growth in vivo and inhibited pS6 in the implanted tumors. In conclusion, by studying the kinase profile of colorectal tumors, we identified relevant activated pathways, and a new multi-kinase compound with significant antitumor properties. PMID:26418718

  10. KinasePA: Phosphoproteomics data annotation using hypothesis driven kinase perturbation analysis

    Science.gov (United States)

    Yang, Pengyi; Patrick, Ellis; Humphrey, Sean J.; Ghazanfar, Shila; James, David E.; Jothi, Raja; Yang, Jean Yee Hwa

    2016-01-01

    Mass spectrometry (MS)-based quantitative phosphoproteomics has become a key approach for proteome-wide profiling of phosphorylation in tissues and cells. Traditional experimental design often compares a single treatment with a control, whereas increasingly more experiments are designed to compare multiple treatments with respect to a control. To this end, the development of bioinformatic tools that can integrate multiple treatments and visualise kinases and substrates under combinatorial perturbations is vital for dissecting concordant and/or independent effects of each treatment. Here, we propose a hypothesis driven kinase perturbation analysis (KinasePA) to annotate and visualise kinases and their substrates that are perturbed by various combinatorial effects of treatments in phosphoproteomics experiments. We demonstrate the utility of KinasePA through its application to two large-scale phosphoproteomics datasets and show its effectiveness in dissecting kinases and substrates within signalling pathways driven by unique combinations of cellular stimuli and inhibitors. We implemented and incorporated KinasePA as part of the “directPA” R package available from the comprehensive R archive network (CRAN). Furthermore, KinasePA also has an interactive web interface that can be readily applied to annotate user provided phosphoproteomics data (http://kinasepa.pengyiyang.org). PMID:27145998

  11. KinasePA: Phosphoproteomics data annotation using hypothesis driven kinase perturbation analysis.

    Science.gov (United States)

    Yang, Pengyi; Patrick, Ellis; Humphrey, Sean J; Ghazanfar, Shila; James, David E; Jothi, Raja; Yang, Jean Yee Hwa

    2016-07-01

    Mass spectrometry (MS)-based quantitative phosphoproteomics has become a key approach for proteome-wide profiling of phosphorylation in tissues and cells. Traditional experimental design often compares a single treatment with a control, whereas increasingly more experiments are designed to compare multiple treatments with respect to a control. To this end, the development of bioinformatic tools that can integrate multiple treatments and visualise kinases and substrates under combinatorial perturbations is vital for dissecting concordant and/or independent effects of each treatment. Here, we propose a hypothesis driven kinase perturbation analysis (KinasePA) to annotate and visualise kinases and their substrates that are perturbed by various combinatorial effects of treatments in phosphoproteomics experiments. We demonstrate the utility of KinasePA through its application to two large-scale phosphoproteomics datasets and show its effectiveness in dissecting kinases and substrates within signalling pathways driven by unique combinations of cellular stimuli and inhibitors. We implemented and incorporated KinasePA as part of the "directPA" R package available from the comprehensive R archive network (CRAN). Furthermore, KinasePA also has an interactive web interface that can be readily applied to annotate user provided phosphoproteomics data (http://kinasepa.pengyiyang.org). PMID:27145998

  12. CDPKs are dual-specificity protein kinases and tyrosine autophosphorylation attenuates kinase activity

    Science.gov (United States)

    Calcium-dependent protein kinases (CDPKs or CPKs) are classified as serine/threonine protein kinases but we made the surprising observation that soybean CDPK' and several Arabidopsis isoforms (AtCPK4 and AtCPK34) could also autophosphorylate on tyrosine residues. In studies with His6-GmCDPK', we ide...

  13. Phosphorylation of nm23/nucleoside diphosphate kinase by casein kinase 2 in vitro

    DEFF Research Database (Denmark)

    Engel, M; Issinger, O G; Lascu, I;

    1994-01-01

    We have investigated phosphorylation of human nucleoside diphosphate kinase (NDPK) and of homologous NDPK from different species by human casein kinase 2 (CK-2). The human NDPK isotypes A and B were phosphorylated by CK-2 in vitro both when the purified proteins and total lysate of HL-60 leukemia...

  14. A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs

    NARCIS (Netherlands)

    Burgers, Pepijn P; van der Heyden, MAG; Kok, Bart; Heck, Albert J R; Scholten, Arjen

    2015-01-01

    Protein kinase A (PKA) in vertebrates is localized to specific locations in the cell via A-kinase anchoring proteins (AKAPs). The regulatory subunits of the four PKA isoforms (RIα, RIβ, RIIα, and RIIβ) each form a homodimer, and their dimerization domain interacts with a small helical region present

  15. Regulation of the MAP kinase cascade in PC12 cells: B-Raf activates MEK-1 (MAP kinase or ERK kinase) and is inhibited by cAMP

    DEFF Research Database (Denmark)

    Peraldi, P; Frödin, M; Barnier, J V;

    1995-01-01

    In PC12 cells, cAMP stimulates the MAP kinase pathway by an unknown mechanism. Firstly, we examined the role of calcium ion mobilization and of protein kinase C in cAMP-stimulated MAP kinase activation. We show that cAMP stimulates p44mapk independently of these events. Secondly, we studied the r...

  16. Single-Phase Direct AC-AC Boost Converter

    Directory of Open Access Journals (Sweden)

    LUCANU, M.

    2014-08-01

    Full Text Available The paper presents a single-phase direct AC-AC boost converter. The circuit of the converter is simple and it has good performances, irrespective of the load nature. The adequate functioning and high performance of the circuit (the efficiency and waveform of the absorbed input current were tested both by simulation and experimentally.

  17. Combined performance of photodiode matrices with electron-optical converters

    International Nuclear Information System (INIS)

    As applied to plasma diagnostics using the methods of laser scattering, a necessity to use an electron-optical converter aheat of photodiode matrices is pointed out. Investigation results of the MF-16 integrated photodiode matrix performance in combination with various electron-optical convertes are presented. The possibility to use the system for recording weak pulse optical signals is shown

  18. Modeling and simulation of matrix converter for wind power generation

    International Nuclear Information System (INIS)

    In this paper, a matrix converter structure is proposed which is suitable for wind power generation applications. The matrix converter (MC) is the most general converter type in the family of AC-AC converters. It is a single-stage converter which has an array of m x n bidirectional power switches to connect, directly, an m- phase voltage source to an n-Phase load. It does not have any DC-link circuit and does not need any large energy storage elements. The key element in a matrix converter is the fully controlled four quadrant bidirectional switch, which allows highfrequency operation. The proposed converter uses MOSFETs as bidirectional switches. The model has been implemented using MATLAB/SIMULINK. The results obtained are presented. The waveforms for input current and output voltage are sinusoidal with very low total harmonic distortion (THD). Low THD is an indication that the model is suitable for wind power generation applications. The simulation results confirm the reduction of conversion losses by 10% to 12% as compared to conventional two stage converters thereby increasing the overall conversion efficiency. The MOSFETs which have been used as switching devices have four to five times more switching frequency as compared to IGBTs thus improving the resulting wave shapes. (author)

  19. Quantum cascade lasers with an integrated polarization mode converter.

    Science.gov (United States)

    Dhirhe, D; Slight, T J; Holmes, B M; Hutchings, D C; Ironside, C N

    2012-11-01

    We discuss the design, fabrication and characterization of waveguide polarization mode converters for quantum cascade lasers operating at 4.6 μm. We have fabricated a quantum cascade laser with integrated polarization mode converter that emits light of 69% Transverse Electrical (TE) polarization from one facet and 100% Transverse Magnetic (TM) polarization from the other facet. PMID:23187389

  20. Quantum cascade lasers with an integrated polarization mode converter

    OpenAIRE

    Dhirhe, D.; Slight, T.J.; Holmes, B.M.; Hutchings, D.C.; Ironside, C. N.

    2012-01-01

    We discuss the design, fabrication and characterization of waveguide polarization mode converters for quantum cascade lasers operating at 4.6 μm. We have fabricated a quantum cascade laser with integrated polarization mode converter that emits light of 69% Transverse Electrical (TE) polarization from one facet and 100% Transverse Magnetic (TM) polarization from the other facet.

  1. Low input voltage converter/regulator minimizes external disturbances

    Science.gov (United States)

    1966-01-01

    Low-input voltage converter/regulator constructed in a coaxial configuration minimizes external magnetic field disturbance, suppresses radio noise interference, and provides excellent heat transfer from power transistors. It converts the output of fuel and solar cells, thermionic diodes, thermoelectric generators, and electrochemical batteries to a 28 V dc output.

  2. REQUIREMENTS AND CONSTRUCTIVE DIFFERENCES OF A STATIC CONVERTER

    Directory of Open Access Journals (Sweden)

    Uskov A. E.

    2015-03-01

    Full Text Available In this article technical requirements to static converters are examined. We can treat as the basic parameters: efficiency and quality of a target voltage. Weight-dimensional parameters, reliability, maintainability are basic operational parameters, as well as target capacity, size of an starting and target voltage belong to key parameters of static converters. As a rule designing of converters is a uniform constructive complex. As at designing, time of an operating time until first failure is taken into account, time of guaranteed work of the separate elements included in the static converter, are determined on the statistical data. Failure of separate elements of parts of converters are possible because of internal (time of guaranteed work and external (short circuits, overloads factors. In the article we have offered the ways of reduction of influence of external factors (for example, we used high-speed automatic switches or iterative static converters in which parts of a power circuit were included in parallel. Using universal static converters allows raising some parameters of efficiency simultaneously. In the article we have also considered a scheme of the iterative converter with variable structure which allows (depending on start and target conditions or requirements forming an output capacity of the required level and quality without constructive change

  3. Impedance Coordinative Control for Cascaded Converter in Bidirectional Application

    DEFF Research Database (Denmark)

    Tian, Yanjun; Deng, Fujin; Chen, Zhe;

    2015-01-01

    difference between forward and reversed power flow. This paper addresses the analysis with the topology of cascaded dual-active-bridge converter (DAB) with inverter, and the proposed control method can also be implemented in unidirectional applications and other general cascaded converter system...

  4. Optimization Control of Bidirectional Cascaded DC-AC Converter Systems

    DEFF Research Database (Denmark)

    Tian, Yanjun

    in bidirectional cascaded converter. This research work analyses the control strategies based on the topology of dual active bridges converter cascaded with a three phase inverter. It firstly proposed a dc link voltage and active power coordinative control method for this cascaded topology, and it can reduce dc...

  5. Very High Frequency Half Bridge DC/DC Converter

    DEFF Research Database (Denmark)

    Madsen, Mickey Pierre; Knott, Arnold; Andersen, Michael A. E.

    2014-01-01

    This paper presents the first, off chip, class DE (resonant half bridge) converter working in the Very High Frequency (VHF) range. The benefits of using half bridge circuits both in the inverter and rectifier part of a VHF resonant dc/dc converter are analyzed and design equations for all...

  6. Charge pump DC-DC converter comprising solid state batteries

    NARCIS (Netherlands)

    Reefman, D.; Roozeboom, F.; Notten, P.H.L.; Klootwijk, J.H.

    2013-01-01

    An electronic device is provided which comprises a DC-DC converter. The DC-DC converter comprises at least one solid-state rechargeable battery (B1, B2) for storing energy for the DC-DC conversion and an output capacitor (C2).

  7. Intelligent dc-dc Converter Technology Developed and Tested

    Science.gov (United States)

    Button, Robert M.

    2001-01-01

    The NASA Glenn Research Center and the Cleveland State University have developed a digitally controlled dc-dc converter to research the benefits of flexible, digital control on power electronics and systems. Initial research and testing has shown that conventional dc-dc converters can benefit from improved performance by using digital-signal processors and nonlinear control algorithms.

  8. 40 CFR 89.317 - NOX converter check.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false NOX converter check. 89.317 Section 89... Provisions § 89.317 NOX converter check. (a) Prior to its introduction into service, and monthly thereafter... of the NOX generator to the sample inlet of the oxides of nitrogen analyzer which has been set to...

  9. Pilot tones in WDM networks with wavelength converters

    DEFF Research Database (Denmark)

    Kloch, Allan; Mikkelsen, Benny; Stubkjær, Kristian

    1997-01-01

    Here we investigate the transmission of a pilot tone through an interferometric wavelength converter (IWC) in conjunction with a 2.5 Gbit/s experiment. The pilot tone is added by sinusoidal modulation of the bias current to the signal laser. After the IWC (Michelson interferometer) the converted...

  10. Advanced catalytic converter system for natural gas powered diesel engines

    Energy Technology Data Exchange (ETDEWEB)

    Strots, V.O.; Bunimovich, G.A.; Matros, Y.S. [Matros Technologies Inc., Chesterfield, Missouri (United States); Zheng, M.; Mirosh, E.A. [Alternative Fuel Systems Inc., Calgary, Alberta (Canada)

    1998-12-31

    The paper discusses the development of catalytic converter for aftertreatment of exhaust gas from diesel engines powered with natural gas. The converter, operated with periodical reversals of the flow, ensures destruction of CO and hydrocarbons, including methane. Both computer simulation and engine testing results are presented. 8 refs.

  11. Optimizing design of converters using power cycling lifetime models

    DEFF Research Database (Denmark)

    Nielsen, Rasmus Ørndrup; Munk-Nielsen, Stig

    2015-01-01

    Converter power cycling lifetime depends heavily on converter operation point. A lifetime model of a single power module switched mode power supply with wide input voltage range is shown. A lifetime model is created using a power loss model, a thermal model and a model for power cycling capability...

  12. LLCL-Filtered Grid Converter with Improved Stability and Robustness

    DEFF Research Database (Denmark)

    Min, Huang; Wang, Xiongfei; Loh, Poh Chiang;

    2016-01-01

    method even with no damping added to the grid converter. The method has been applied to the development of an LLCL-filter for testing in the laboratory with a 5-kW, 400-V, and 50-Hz grid converter. The method can also be applied to the lower order LCL-filter with only a slight modification needed....

  13. Hydraulic Evaluation of the Crest Wing Wave Energy Converter

    DEFF Research Database (Denmark)

    Kofoed, Jens Peter; Antonishen, Michael Patrick

    This report presents the results of an experimental study of the wave energy converting abilities of the Crest Wing wave energy converter (WEC). The Crest Wing is a WEC that uses its movement in matching the shape of an oncoming wave to generate power. Model tests have been performed using a scal...

  14. Development of a test platform for controlling parallel converters

    DEFF Research Database (Denmark)

    Bede, Lorand; Kopacz, Csaba; Kerekes, Tamas;

    2014-01-01

    a proper interleaving angle between the converters the current ripple can be reduced considerably. In order to be able to investigate the performance of these converters a safe and cheap platform is essential. The development of a test platform for such an application is challenging, since a proper...

  15. Gunning Mix or Converter and Electric Arc Furnace in China

    Institute of Scientific and Technical Information of China (English)

    LIUJie-hua; ZHANGYong-fang

    1996-01-01

    The increase of steel output by converter and electric are furnace has imposed a critical demand in quality and quantity on gunning mix in functioning a longer life of those de-vices linings.The paoer describes the consump-tion of gunning mix for converter and EAF and its recent development in variety and quality in China.

  16. A generic converter for experimentation based power electronics learning

    OpenAIRE

    Leite, V; Barbosa, José; Teixeira, H.; Araújo, R.

    2005-01-01

    This paper presents a low cost, modular, configurable and fully protected education tool based on a generic electronic converter to be used by students, providing them with skills regarding power electronics and converters, and enabling them to learn from experience the most important issues concerning DC and AC electric drives.

  17. Four-quadrant flyback converter for direct audio power amplification

    DEFF Research Database (Denmark)

    Ljusev, Petar; Andersen, Michael Andreas E.

    2005-01-01

    This paper presents a bidirectional, four-quadrant flyback converter for use in direct audio power amplification. When compared to the standard Class-D switching audio power amplifier with a separate power supply, the proposed four-quadrant flyback converter provides simple solution with better...

  18. A Boosting Multi Flyback Converter for Electric Vehicle Application

    Directory of Open Access Journals (Sweden)

    J. Sangeetha

    2015-08-01

    Full Text Available The Flyback converter belongs to the primary switched converter family, which means there is isolation between input and output. Flyback converters have low number of components compared to other Switched Mode Power Supplies (SMPSs, they also have the advantage that several isolated output voltages can be regulated by one control circuit. This study proposes an efficient and cost effective Multi Flyback topology, an isolated DC-DC converter suitable for electric vehicle applications especially driven with induction motor. The converter topology forms a power interface between the battery and the motor and also capable of boosting the voltage from low voltage battery side to high voltage DC link. A Multi Flyback Converter topology implemented by paralleling three individual flyback converters at the battery input side and DC link output side. The topology will share the current across each individual converter and the individual power will be added up at the output side. The scheme incorporates a transformer winding technique which can reduce the leakage inductance of the coupled inductor to a satisfactory limit.

  19. An improved 4-step commutation method application for matrix converter

    DEFF Research Database (Denmark)

    Guo, Yu; Guo, Yougui; Deng, Wenlang;

    2014-01-01

    A novel four-step commutation method is proposed for matrix converter cell, 3 phase inputs to 1 phase output in this paper, which is obtained on the analysis of published commutation methods for matrix converter. The first and fourth step can be shorter than the second or third one. The discussed...

  20. Janus kinase inhibitors: jackpot or potluck?

    Directory of Open Access Journals (Sweden)

    Pavithran Keechilat

    2012-06-01

    Full Text Available The reports of a unique mutation in the Janus kinase-2 gene (JAK2 in polycythemia vera by several independent groups in 2005 quickly spurred the development of the Janus kinase inhibitors. In one of the great victories of translational research in recent times, the first smallmolecule Janus kinase inhibitor ruxolitinib entered a phase I trial in 2007. With the approval of ruxolitinib by the US Federal Drug Administration in November 2011 for high-risk and intermediate-2 risk myelofibrosis, a change in paradigm has occurred in the management of a subset of myeloproliferative neoplasms (MPN: primary myelofibrosis, post-polycythemia vera myelofibrosis, and post-essential thrombocythemia myelofibrosis. Whereas the current evidence for ruxolitinib only covers high-risk and intermediate-2 risk myelofibrosis, inhibitors with greater potency are likely to offer better disease control and survival advantage in patients belonging to these categories, and possibly to the low-risk and intermediate-1 risk categories of MPN as well. But use of the Janus kinase inhibitors also probably has certain disadvantages, such as toxicity, resistance, withdrawal phenomenon, non-reversal of histology, and an implausible goal of disease clone eradication, some of which could offset the gains. In spite of this, Janus kinase inhibitors are here to stay, and for use in more than just myeloproliferative neoplasms.

  1. Mechanism of polyphosphate kinase from Propionibacterium shermanii

    International Nuclear Information System (INIS)

    Polyphosphate kinase, which catalyzes the reaction shown below, is one of two enzymes which have been reported to catalyze the synthesis of polyphosphate. Purification performed by ammonium sulfate precipitation (0-40% fraction) was followed by chromatography. The enzyme represents 70% of the protein in the hydroxylapatite pool and is stable at this level of purity. The subunit molecular weight was determined by SDS polyacrylamide gel analysis, (83,000 +/- 3000), nondenaturing polyacrylamide gel electrophoresis, (80,000 and 86,000 daltons), gel filtration (Biogel A 0.5m column was 85,000 +/- 4000.) Polyphosphate kinase appears to be a monomeric enzyme of ∼83,000 daltons. Four assays were developed for polyphosphate kinase. Basic proteins such as polylysine stimulate the synthesis of polyphosphate, these proteins cause precipitation of polyphosphate kinase from relatively impure enzyme extracts: Synthesized polyphosphate interacts noncovalently with the basic protein-enzyme precipitate. Efficient synthesis of polyphosphate requires the addition of either phosphate or short chain polyphosphate. Synthesis did occur at 1/10 the rate when neither of these two compounds were included. Initiation, elongation, and termination events of polyphosphate synthesis were examined. Short chain polyphosphate acts as a primer, with [32P] short-chain polyphosphate incorporation into long chain polyphosphate by the kinase

  2. Analysis of a novel phase-shifted soft switch converter

    Institute of Scientific and Technical Information of China (English)

    蒋志宏; 黄立培; 张义

    2002-01-01

    In this paper, on the basis of the phase-shifted controlled zero-voltage-switch (ZVS) full-bridge converter with pulse width modulation (PWM), a novel zero-voltage and zero-current switch (ZVZCS) PWM converter using a simple auxiliary circuit was designed. The ZVZCS soft switch is achieved by the resonance among the resisting electromagnetic deflection capacitor, the capacitor of the simple auxiliary network and the leakage inductor of transformer. There are no dissipation devices of the saturation inductor and the auxiliary switch in the converter, meantime the capacitor of the auxiliary circuit is also used to clamp the voltage of the rectifier, and there is no additional clamped circuit. There is no big circulating current in the converter, all the active and passive devices work on the condition of the low current and voltage stress, and the proposed converter has wide load range and small duty loss.

  3. A study of Schwarz converters for nuclear powered spacecraft

    Science.gov (United States)

    Stuart, Thomas A.; Schwarze, Gene E.

    1987-01-01

    High power space systems which use low dc voltage, high current sources such as thermoelectric generators, will most likely require high voltage conversion for transmission purposes. This study considers the use of the Schwarz resonant converter for use as the basic building block to accomplish this low-to-high voltage conversion for either a dc or an ac spacecraft bus. The Schwarz converter has the important assets of both inherent fault tolerance and resonant operation; parallel operation in modular form is possible. A regulated dc spacecraft bus requires only a single stage converter while a constant frequency ac bus requires a cascaded Schwarz converter configuration. If the power system requires constant output power from the dc generator, then a second converter is required to route unneeded power to a ballast load.

  4. High-feedback Operation of Power Electronic Converters

    DEFF Research Database (Denmark)

    Zhusubaliyev, Zhanybai T.; Mosekilde, Erik; Andriyanov, Alexey I.;

    2013-01-01

    The purpose of this review is to provide a survey of some of the most important bifurcation phenomena that one can observe in pulse-modulated converter systems when operating with high corrector gain factors. Like other systems with switching control, electronic converter systems belong to the cl......The purpose of this review is to provide a survey of some of the most important bifurcation phenomena that one can observe in pulse-modulated converter systems when operating with high corrector gain factors. Like other systems with switching control, electronic converter systems belong...... or resonant periodic dynamics on the surface of a two-dimensional torus. This transition occurs when the feedback gain is increased beyond a certain threshold, for instance in order to improve the speed and accuracy of the output voltage regulation. For each of the three converter types, we discuss a number...

  5. Dividends Sharing Convertible Bonds Pricing and Numerical Evaluation

    Directory of Open Access Journals (Sweden)

    Xu Guo

    2013-01-01

    Full Text Available The convertible bond is becoming one of the most important financial instruments for the company to raise capital fund since it was first issued by American New York Erie Company in 1843. In this paper, it is the first time to study the pricing problem for convertible bond whose underlying stocks pay dividends via the reflected backward stochastic differential equations. Associating the solutions of reflected BSDEs with the obstacle problems for nonlinear parabolic PDEs, we establish the pricing formulas for convertible bonds with continuous and discrete dividends by means of the viscosity solutions for some PDEs. Besides, we also derive the price of convertible bonds with higher borrowing rate which is realistic in the financial market. Then the numerical evaluations are provided by the radial basis functions method. Moreover, we discuss the influence of dividends paying as well as higher borrowing rate on the convertible bond price at last.

  6. The New Modular Control System for Power Converters at CERN

    CERN Document Server

    Di Cosmo, Matteo

    2015-01-01

    The CERN accelerator complex consists of several generations of particle accelerators, with around 5000 power converters supplying regulated current and voltage to normal and superconducting magnet circuits. Today around 12 generations of converter control platforms can be found in the accelerator complex, ranging in age and technology. The diversity of these platforms has a significant impact on operability, maintenance and support of power converters. Over the past few years a new generation of modular controls called RegFGC3 has been developed by CERN’s power conversion group, with a goal to provide a standardised control platform, supporting a wide variety of converter topologies. The aim of this project is to reduce maintenance costs by decreasing the variety and diversity of control systems whilst simultaneously improving the operability and reliability of power converters and their controls. This paper describes the state of the on-going design and realization of the RegFGC3 platform, focusing on fun...

  7. CAS CERN Accelerator School: Power converters for particle accelerators

    International Nuclear Information System (INIS)

    This volume presents the proceedings of the fifth specialized course organized by the CERN Accelerator School, the subject on this occasion being power converters for particle accelerators. The course started with lectures on the classification and topologies of converters and on the guidelines for achieving high performance. It then went on to cover the more detailed aspects of feedback theory, simulation, measurements, components, remote control, fault diagnosis and equipment protection as well as systems and grid-related problems. The important topics of converter specification, procurement contract management and the likely future developments in semiconductor components were also covered. Although the course was principally directed towards DC and slow-pulsed supplies, lectures were added on fast converters and resonant excitation. Finally the programme was rounded off with three seminars on the related fields of Tokamak converters, battery energy storage for electric vehicles, and the control of shaft generators in ships. (orig.)

  8. Design of Monolithic Integrator for Strain-to-Frequency Converter

    Directory of Open Access Journals (Sweden)

    Tuan Mohd. Khairi Tuan Mat

    2012-01-01

    Full Text Available Strain-to-Frequency converter (SFC is a one of the analog conditioner tools that converts any strain signal to the frequency signal. The basic concept of SFC is by detecting any changing of strains, then converting the strain to the voltage signal and converting the voltage signal to the frequency signal. This tool consists of 3 main  components which are strain gauge, differential integrator and comparator. This paper presents the designing and analysis of monolithic integrator that to be used in the Strain-toFrequency converter. The primary goal is to design and simulate the performance of monolithic integrator for SFC using GATEWAY Silvaco Electronic Design Automation (S EDA tools and EXPERT software. The performances of SFC using the designed monolithic integrator are also investigated.

  9. High Speed Level Converters With Short Circuit Current Reduction

    Directory of Open Access Journals (Sweden)

    Avireni Srinivasulu

    2014-08-01

    Full Text Available The level converter is used as interface between low voltages to high voltage boundary. The efficient level converter has less power consumption and less delay are the design considerations of the level shifter. In this paper two new CMOS level converters are presented with high driving capability with low propagation delay. The proposed level converters are simulated using Cadence software with 0.18 µm CMOS technology. The simulation result shows that the proposed circuits have less propagation delay than the existing ones. The circuits are simulated for different load capacitor values and different voltages. The proposed level converters operate for different input pulse signal amplitude values are +0.8 V, +1 V, +1.2 V and VDDH values of +1.8 V and +3.3 V.

  10. Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase.

    Directory of Open Access Journals (Sweden)

    Mohini S Ghatge

    Full Text Available Pyridoxal 5'-phosphate (PLP is a cofactor for dozens of B(6 requiring enzymes. PLP reacts with apo-B(6 enzymes by forming an aldimine linkage with the ε-amino group of an active site lysine residue, thus yielding the catalytically active holo-B(6 enzyme. During protein turnover, the PLP is salvaged by first converting it to pyridoxal by a phosphatase and then back to PLP by pyridoxal kinase. Nonetheless, PLP poses a potential toxicity problem for the cell since its reactive 4'-aldehyde moiety forms covalent adducts with other compounds and non-B(6 proteins containing thiol or amino groups. The regulation of PLP homeostasis in the cell is thus an important, yet unresolved issue. In this report, using site-directed mutagenesis, kinetic, spectroscopic and chromatographic studies we show that pyridoxal kinase from E. coli forms a complex with the product PLP to form an inactive enzyme complex. Evidence is presented that, in the inhibited complex, PLP has formed an aldimine bond with an active site lysine residue during catalytic turnover. The rate of dissociation of PLP from the complex is very slow, being only partially released after a 2-hour incubation with PLP phosphatase. Interestingly, the inactive pyridoxal kinase•PLP complex can be partially reactivated by transferring the tightly bound PLP to an apo-B(6 enzyme. These results open new perspectives on the mechanism of regulation and role of pyridoxal kinase in the Escherichia coli cell.

  11. Protein Kinases and Parkinson’s Disease

    Science.gov (United States)

    Mehdi, Syed Jafar; Rosas-Hernandez, Hector; Cuevas, Elvis; Lantz, Susan M.; Barger, Steven W.; Sarkar, Sumit; Paule, Merle G.; Ali, Syed F.; Imam, Syed Z.

    2016-01-01

    Currently, the lack of new drug candidates for the treatment of major neurological disorders such as Parkinson’s disease has intensified the search for drugs that can be repurposed or repositioned for such treatment. Typically, the search focuses on drugs that have been approved and are used clinically for other indications. Kinase inhibitors represent a family of popular molecules for the treatment and prevention of various cancers, and have emerged as strong candidates for such repurposing because numerous serine/threonine and tyrosine kinases have been implicated in the pathobiology of Parkinson’s disease. This review focuses on various kinase-dependent pathways associated with the expression of Parkinson’s disease pathology, and evaluates how inhibitors of these pathways might play a major role as effective therapeutic molecules. PMID:27657053

  12. Kinase signaling in the spindle checkpoint.

    Science.gov (United States)

    Kang, Jungseog; Yu, Hongtao

    2009-06-01

    The spindle checkpoint is a cell cycle surveillance system that ensures the fidelity of chromosome segregation. In mitosis, it elicits the "wait anaphase" signal to inhibit the anaphase-promoting complex or cyclosome until all chromosomes achieve bipolar microtubule attachment and align at the metaphase plate. Because a single kinetochore unattached to microtubules activates the checkpoint, the wait anaphase signal is thought to be generated by this kinetochore and is then amplified and distributed throughout the cell to inhibit the anaphase-promoting complex/cyclosome. Several spindle checkpoint kinases participate in the generation and amplification of this signal. Recent studies have begun to reveal the activation mechanisms of these checkpoint kinases. Increasing evidence also indicates that the checkpoint kinases not only help to generate the wait anaphase signal but also actively correct kinetochore-microtubule attachment defects. PMID:19228686

  13. The Role of PAS Kinase in PASsing the Glucose Signal

    Directory of Open Access Journals (Sweden)

    Julianne H. Grose

    2010-06-01

    Full Text Available PAS kinase is an evolutionarily conserved nutrient responsive protein kinase that regulates glucose homeostasis. Mammalian PAS kinase is activated by glucose in pancreatic beta cells, and knockout mice are protected from obesity, liver triglyceride accumulation, and insulin resistance when fed a high-fat diet. Yeast PAS kinase is regulated by both carbon source and cell integrity stress and stimulates the partitioning of glucose toward structural carbohydrate biosynthesis. In our current model for PAS kinase regulation, a small molecule metabolite binds the sensory PAS domain and activates the enzyme. Although bona fide PAS kinase substrates are scarce, in vitro substrate searches provide putative targets for exploration.

  14. Measuring MAP kinase activity in immune complex assays.

    Science.gov (United States)

    Cherkasova, Vera A

    2006-11-01

    I present an overview of published methods for measuring mitogen activated protein (MAP) kinase activity on endogenous associated substrates, exogenously added substrates as well as determination of activation loop phosphorylation as a read-out of kinase activity in vivo. Detailed procedures for these assays are given for two MAP kinases (MAPKs) Fus3 and Kss1 and compared with other published protocols, including the protocols for Hog1 and Mpk1 MAPKs. Measuring kinase activity in immune complex assays can serve as an approach for identification of potential substrates of protein kinases as well as for detecting other kinase-associated proteins. PMID:16890454

  15. Novel family of quasi-Z-source DC/DC converters derived from current-fed push-pull converters

    DEFF Research Database (Denmark)

    Chub, Andrii; Husev, Oleksandr; Vinnikov, Dmitri;

    2014-01-01

    This paper is devoted to the step-up quasi-Z-source dc/dc push-pull converter family. The topologies in the family are derived from the isolated boost converter family by replacing input inductors with the quasi-Z-source network. Two new topologies are proposed, analyzed and compared. Theoretical...

  16. X-Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase

    Energy Technology Data Exchange (ETDEWEB)

    Muckelbauer, Jodi; Sack, John S.; Ahmed, Nazia; Burke, James; Chang, ChiehYing Y.; Gao, Mian; Tino, Joseph; Xie, Dianlin; Tebben, Andrew J. (BMS)

    2012-06-27

    Bone marrow kinase in the X chromosome, a member of the Tec family of tyrosine kinases, plays a role in both monocyte/macrophage trafficking as well as cytokine secretion. Although the structures of Tec family kinases Bruton's tyrosine kinase and IL-2-inducible T-cell kinase are known, the crystal structures of other Tec family kinases have remained elusive. We report the X-ray crystal structures of bone marrow kinase in the X chromosome in complex with dasatinib at 2.4 {angstrom} resolution and PP2 at 1.9 {angstrom} resolution. The bone marrow kinase in the X chromosome structures reveal a typical kinase protein fold; with well-ordered protein conformation that includes an open/extended activation loop and a stabilized DFG-motif rendering the kinase in an inactive conformation. Dasatinib and PP2 bind to bone marrow kinase in the X chromosome in the ATP binding pocket and display similar binding modes to that observed in other Tec and Src protein kinases. The bone marrow kinase in the X chromosome structures identify conformational elements of the DFG-motif that could potentially be utilized to design potent and/or selective bone marrow kinase in the X chromosome inhibitors.

  17. Cloning and expression of the heterodimeric deoxyguanosine kinase/deoxyadenosine kinase of Lactobacillus acidophilus R-26.

    Science.gov (United States)

    Ma, G T; Hong, Y S; Ives, D H

    1995-03-24

    Two uniquely paired deoxynucleoside kinases, deoxycytidine kinase/deoxyadenosine kinase (dCK/dAK) and deoxyguanosine kinase/deoxyadenosine kinase (dGK/dAK) are required, together with thymidine kinase (TK), for deoxynucleotide synthesis in Lactobacillus acidophilus R-26. Using polymerase chain reaction-generated probes based on N-terminal amino acid sequences, we have cloned tandem genes for 25- and 26-kDa polypeptides, whose derived amino acid sequences and size correspond to wild-type Lactobacillus enzyme subunits. Expression in Escherichia coli uses a single endogenous promoter and yields active dGK/dAK (approximately 3% of extracted protein) closely resembling wild-type dGK/dAK in specificity, kinetics, heterotropic activation, and end product inhibition. Alignment of cloned genes reveals 65% identity in their DNA sequences and 61% identity in derived amino acid sequences. Comparison with herpes-viral TKs reveals three conserved regions: glycine- and arginine-rich ATP-binding motifs and a D/E-R-S/H motif at the putative TK deoxynucleoside site. Greater homology, however, is seen upon multiple alignment of dGK with mammalian deoxycytidine kinases, yielding the consensus sequence-D/E-R-S-I/V-Y-x-D-.dGK also shares a sequence (-Y-D-P-T-I/L-E-D-S/Y-Y-) required for GTP hydrolysis by p21ras.

  18. Rational design of protein kinase inhibitors

    Directory of Open Access Journals (Sweden)

    Yarmoluk S. M.

    2013-07-01

    Full Text Available Modern methodological approaches to rational design of low molecular weight compounds with specific activity in relation to predetermined biomolecular targets are considered by example of development of high effective protein kinase inhibitors. The application of new computational methods that allow to significantly improve the quality of computational experiments (in, particular, accuracy of low molecular weight compounds activity prediction without increase of computational and time costs are highlighted. The effectiveness of strategy of rational design is demonstrated by examples of several own investigations devoted to development of new inhibitors that are high effective and selective towards protein kinases CK2, FGFR1 and ASK1.

  19. Purification and characterization of a casein kinase 2-type protein kinase from pea nuclei

    Science.gov (United States)

    Li, H.; Roux, S. J.

    1992-01-01

    Almost all the polyamine-stimulated protein kinase activity associated with the chromatin fraction of nuclei purified from etiolated pea (Pisum sativum L.) plumules is present in a single enzyme that can be extracted from chromatin by 0.35 molar NaCl. This protein kinase can be further purified over 2000-fold by salt fractionation and anion-exchange and casein-agarose column chromatography, after which it is more than 90% pure. The purified kinase has a specific activity of about 650 nanomoles per minute per milligram protein in the absence of polyamines, with either ATP or GTP as phosphoryl donor. Spermidine can stimulate its activity fourfold, with half-maximal activation at about 2 millimolar. Spermine and putrescine also stimulate activity, although somewhat less effectively. This kinase has a tetrameric alpha 2 beta 2 structure with a native molecular weight of 130,000, and subunit molecular weights of 36,000 for the catalytic subunit (alpha) and 29,000 for the regulatory subunit (beta). In western blot analyses, only the alpha subunit reacts strongly with polyclonal antibodies to a Drosophila casein kinase II. The pea kinase can use casein and phosvitin as artificial substrates, phosphorylating both the serine and threonine residues of casein. It has a pH optimum near 8.0, a Vmax of 1.5 micromoles per minute per milligram protein, and a Km for ATP of approximately 75 micromolar. Its activity can be almost completely inhibited by heparin at 5 micrograms per milliliter, but is relatively insensitive to concentrations of staurosporine, K252a, and chlorpromazine that strongly antagonize Ca(2+) -regulated protein kinases. These results are discussed in relation to recent findings that casein kinase 2-type kinases may phosphorylate trans-acting factors that bind to light-regulated promoters in plants.

  20. Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity.

    Science.gov (United States)

    Luz, Simão; Kongsuphol, Patthara; Mendes, Ana Isabel; Romeiras, Francisco; Sousa, Marisa; Schreiber, Rainer; Matos, Paulo; Jordan, Peter; Mehta, Anil; Amaral, Margarida D; Kunzelmann, Karl; Farinha, Carlos M

    2011-11-01

    Previously, the pleiotropic "master kinase" casein kinase 2 (CK2) was shown to interact with CFTR, the protein responsible for cystic fibrosis (CF). Moreover, CK2 inhibition abolished CFTR conductance in cell-attached membrane patches, native epithelial ducts, and Xenopus oocytes. CFTR possesses two CK2 phosphorylation sites (S422 and T1471), with unclear impact on its processing and trafficking. Here, we investigated the effects of mutating these CK2 sites on CFTR abundance, maturation, and degradation coupled to effects on ion channel activity and surface expression. We report that CK2 inhibition significantly decreased processing of wild-type (wt) CFTR, with no effect on F508del CFTR. Eliminating phosphorylation at S422 and T1471 revealed antagonistic roles in CFTR trafficking: S422 activation versus T1471 inhibition, as evidenced by a severe trafficking defect for the T1471D mutant. Notably, mutation of Y512, a consensus sequence for the spleen tyrosine kinase (SYK) possibly acting in a CK2 context adjacent to the common CF-causing defect F508del, had a strong effect on both maturation and CFTR currents, allowing the identification of this kinase as a novel regulator of CFTR. These results reinforce the importance of CK2 and the S422 and T1471 residues for regulation of CFTR and uncover a novel regulation of CFTR by SYK, a recognized controller of inflammation.

  1. Analysis of series resonant converter with series-parallel connection

    Science.gov (United States)

    Lin, Bor-Ren; Huang, Chien-Lan

    2011-02-01

    In this study, a parallel inductor-inductor-capacitor (LLC) resonant converter series-connected on the primary side and parallel-connected on the secondary side is presented for server power supply systems. Based on series resonant behaviour, the power metal-oxide-semiconductor field-effect transistors are turned on at zero voltage switching and the rectifier diodes are turned off at zero current switching. Thus, the switching losses on the power semiconductors are reduced. In the proposed converter, the primary windings of the two LLC converters are connected in series. Thus, the two converters have the same primary currents to ensure that they can supply the balance load current. On the output side, two LLC converters are connected in parallel to share the load current and to reduce the current stress on the secondary windings and the rectifier diodes. In this article, the principle of operation, steady-state analysis and design considerations of the proposed converter are provided and discussed. Experiments with a laboratory prototype with a 24 V/21 A output for server power supply were performed to verify the effectiveness of the proposed converter.

  2. Nonlinear wide-range measuring gamma radiation converter

    International Nuclear Information System (INIS)

    Described is a measuring gamma radiation converter with a continuous law of convertion of the initial parameter into an electric signal. The converter is intended for measuring the gamma radiation dose rate in a wide range. The operating principle of the converter is based on utilization of the nonlinear dependence of the thermomultiplier gain on the feed voltage. The detection block (DB) convert the gamma quanta flux into a sequence of current pulses of the photoelectron multiplier anode (PEM) which are fed into the direct-current amplifier (DCA) input. At the DCA output the voltage modulus decreases by the value proportional to the constant component of the current pulses of the PEM anode. The DCA output signal is represented by two voltage levels: the high level - for employees for the PEM feed, and the low one fed into the voltage-frequency converter (VFC) input. The greater the gamma radiation dose rate, the less is the output pulse recurrence frequency. The structural and principal conversion schemes are presented. The given device can serve as a wide-range measuring converters of luminous radiation of the optical range, infrared and ionizing radiations lead to the luminous radiation with the help of scintillators

  3. Structural evolution of the protein kinase-like superfamily.

    Directory of Open Access Journals (Sweden)

    Eric D Scheeff

    2005-10-01

    Full Text Available The protein kinase family is large and important, but it is only one family in a larger superfamily of homologous kinases that phosphorylate a variety of substrates and play important roles in all three superkingdoms of life. We used a carefully constructed structural alignment of selected kinases as the basis for a study of the structural evolution of the protein kinase-like superfamily. The comparison of structures revealed a "universal core" domain consisting only of regions required for ATP binding and the phosphotransfer reaction. Remarkably, even within the universal core some kinase structures display notable changes, while still retaining essential activity. Hence, the protein kinase-like superfamily has undergone substantial structural and sequence revision over long evolutionary timescales. We constructed a phylogenetic tree for the superfamily using a novel approach that allowed for the combination of sequence and structure information into a unified quantitative analysis. When considered against the backdrop of species distribution and other metrics, our tree provides a compelling scenario for the development of the various kinase families from a shared common ancestor. We propose that most of the so-called "atypical kinases" are not intermittently derived from protein kinases, but rather diverged early in evolution to form a distinct phyletic group. Within the atypical kinases, the aminoglycoside and choline kinase families appear to share the closest relationship. These two families in turn appear to be the most closely related to the protein kinase family. In addition, our analysis suggests that the actin-fragmin kinase, an atypical protein kinase, is more closely related to the phosphoinositide-3 kinase family than to the protein kinase family. The two most divergent families, alpha-kinases and phosphatidylinositol phosphate kinases (PIPKs, appear to have distinct evolutionary histories. While the PIPKs probably have an

  4. Structural Evolution of the Protein Kinase-Like Superfamily.

    Directory of Open Access Journals (Sweden)

    2005-10-01

    Full Text Available The protein kinase family is large and important, but it is only one family in a larger superfamily of homologous kinases that phosphorylate a variety of substrates and play important roles in all three superkingdoms of life. We used a carefully constructed structural alignment of selected kinases as the basis for a study of the structural evolution of the protein kinase-like superfamily. The comparison of structures revealed a "universal core" domain consisting only of regions required for ATP binding and the phosphotransfer reaction. Remarkably, even within the universal core some kinase structures display notable changes, while still retaining essential activity. Hence, the protein kinase-like superfamily has undergone substantial structural and sequence revision over long evolutionary timescales. We constructed a phylogenetic tree for the superfamily using a novel approach that allowed for the combination of sequence and structure information into a unified quantitative analysis. When considered against the backdrop of species distribution and other metrics, our tree provides a compelling scenario for the development of the various kinase families from a shared common ancestor. We propose that most of the so-called "atypical kinases" are not intermittently derived from protein kinases, but rather diverged early in evolution to form a distinct phyletic group. Within the atypical kinases, the aminoglycoside and choline kinase families appear to share the closest relationship. These two families in turn appear to be the most closely related to the protein kinase family. In addition, our analysis suggests that the actin-fragmin kinase, an atypical protein kinase, is more closely related to the phosphoinositide-3 kinase family than to the protein kinase family. The two most divergent families, alpha-kinases and phosphatidylinositol phosphate kinases (PIPKs, appear to have distinct evolutionary histories. While the PIPKs probably have an

  5. Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights

    DEFF Research Database (Denmark)

    Niefind, K; Raaf, J; Issinger, Olaf-Georg

    2009-01-01

    Within the last decade, 40 crystal structures corresponding to protein kinase CK2 (former name 'casein kinase 2'), to its catalytic subunit CK2alpha and to its regulatory subunit CK2beta were published. Together they provide a valuable, yet by far not complete basis to rationalize the biochemical...... critical region of CK2alpha recruitment is pre-formed in the unbound state. In CK2alpha the activation segment - a key element of protein kinase regulation - adapts invariably the typical conformation of the active enzymes. Recent structures of human CK2alpha revealed a surprising plasticity in the ATP...

  6. Architecture for a High-to-Medium-Voltage Power Converter

    Science.gov (United States)

    Vorpenian, Vatche

    2008-01-01

    A power converter now undergoing development is required to operate at a DC input potential ranging between 5.5 and 10 kV and a DC output potential of 400 V at a current up to 25 A. This power converter is also required to be sufficiently compact and reliable to fit and operate within the confines of a high-pressure case to be lowered to several miles (approx.5 km) below the surface of the ocean. The architecture chosen to satisfy these requirements calls for a series/ parallel arrangement of 48 high-frequency, pulse-width-modulation (PWM), transformer-isolation DC-to-DC power converter blocks. The input sides of the converter blocks would be connected in series so that the input potential would be divided among them, each of them being exposed to an input potential of no more than 10 kV/48 . 210 V. The series connection of inputs would also enforce a requirement that all the converter blocks operate at the same input current. The outputs of the converter blocks would be connected in a matrix comprising 6 parallel legs, each leg being a cascade of eight outputs wired in series (see figure). All the converter blocks would be identical within the tolerances of the values of their components. A single voltage feedback loop would regulate the output potential. All the converter blocks would be driven by the same PWM waveform generated by this feedback loop. The power transformer of each converter block would have a unity turns ratio and would be capable of withstanding as much as 10 kVDC between its primary and secondary windings. (Although, in general, the turns ratio could be different from unity, the simplest construction for minimizing leakage and maximizing breakdown voltage is attained at a turns ratio of unity.)

  7. Glycerol hypersensitivity in a Drosophila model for glycerol kinase deficiency is affected by mutations in eye pigmentation genes.

    Directory of Open Access Journals (Sweden)

    Patrick J Wightman

    Full Text Available Glycerol kinase plays a critical role in metabolism by converting glycerol to glycerol 3-phosphate in an ATP dependent reaction. In humans, glycerol kinase deficiency results in a wide range of phenotypic variability; patients can have severe metabolic and CNS abnormalities, while others possess hyperglycerolemia and glyceroluria with no other apparent phenotype. In an effort to help understand the pathogenic mechanisms underlying the phenotypic variation, we have created a Drosophila model for glycerol kinase deficiency by RNAi targeting of dGyk (CG18374 and dGK (CG7995. As expected, RNAi flies have reduced glycerol kinase RNA expression, reduced phosphorylation activity and elevated glycerol levels. Further investigation revealed these flies to be hypersensitive to fly food supplemented with glycerol. Due to the hygroscopic nature of glycerol, we predict glycerol hypersensitivity is a result of greater susceptibility to desiccation, suggesting glycerol kinase to play an important role in desiccation resistance in insects. To evaluate a role for genetic modifier loci in determining severity of the glycerol hypersensitivity observed in knockdown flies, we performed a preliminary screen of lethal transposon insertion mutant flies using a glycerol hypersensitive survivorship assay. We demonstrate that this type of screen can identify both enhancer and suppressor genetic loci of glycerol hypersensitivity. Furthermore, we found that the glycerol hypersensitivity phenotype can be enhanced or suppressed by null mutations in eye pigmentation genes. Taken together, our data suggest proteins encoded by eye pigmentation genes play an important role in desiccation resistance and that eye pigmentation genes are strong modifiers of the glycerol hypersensitive phenotype identified in our Drosophila model for glycerol kinase deficiency.

  8. SINGLE PHASE HIGH FREQUENCY AC CONVERTER FOR INDUCTION HEATING APPLICATION

    Directory of Open Access Journals (Sweden)

    M.A INAYATHULLAAH,

    2010-12-01

    Full Text Available The proposed topology reduces the total harmonic distortion (THD of a high frequency AC/AC Converter well below the acceptable limit. This paper deals with a novel single phase AC/DC/AC soft switching utility frequency AC to high frequency AC converter. In this paper a single phase full bridge inverter with Vienna rectifier as front end is used instead of conventional diode bridge rectifier to provide continuous sinusoidal input current with nearly unity power factor at the source side with extremely low distortion.. This power converter is more suitable and acceptable for cost effective high frequency (HF consumer induction heating applications.

  9. Closed Loop Analysis of Bridgeless SEPIC Converter for Drive Application

    Directory of Open Access Journals (Sweden)

    Gopinath Mani

    2015-06-01

    Full Text Available In this paper closed loop analysis of Single phase AC-DC Bridgeless Single Ended Primary Inductance Converter (SEPIC for Power Factor Correction (PFC rectifier is analyzed. In this topology the absence of an input diode bridge and the due to presence of two semiconductor switches in the current flowing path during each switching cycle which will results in lesser conduction losses and improved thermal management compared to the conventional converters. In this paper the operational principles, Frequency analysis, and design equations of the proposed converter are described in detail. Performance of the proposed SEPIC PFC rectifier are carried out using Matlab Simulink software and results are presented.

  10. Polarization converters based on axially symmetric twisted nematic liquid crystal.

    Science.gov (United States)

    Ko, Shih-Wei; Ting, Chi-Lun; Fuh, Andy Y-G; Lin, Tsung-Hsien

    2010-02-15

    An axially symmetric twisted nematic liquid crystal (ASTNLC) device, based on axially symmetric photoalignment, was demonstrated. Such an ASTNLC device can convert axial (azimuthal) to azimuthal (axial) polarization. The optical properties of the ASTNLC device are analyzed and found to agree with simulation results. The ASTNLC device with a specific device can be adopted as an arbitrary axial symmetric polarization converter or waveplate for axially, azimuthally or vertically polarized light. A design for converting linear polarized light to axially symmetric circular polarized light is also demonstrated. PMID:20389369

  11. Real-time incoherent-to-coherent optical converter

    Science.gov (United States)

    Vohl, P.; Nisenson, P.; Oliver, D. S.

    1973-01-01

    Description of a real-time incoherent-to-coherent optical converter designed for application in image processing systems. The converter utilizes the photoconductivity effect of the compound Bi(12)SiO(20) for spatial modulation of electrical polarization in the compound. An optically absorbed write-in image is stored as an image polarization pattern in the device. Readout is effectuated electrooptically by using phase retardation in a polarized coherent light beam during the passage through the crystal. The operating mode required for achieving continuous image conversion with a high-speed recyclability is discussed. The performance characteristics of the converter are given and the fabrication technology is described.

  12. Parallel Stirling Converters Being Developed for Spacecraft Onboard Power

    Science.gov (United States)

    Thieme, Lanny G.

    1999-01-01

    Stirling Technology Co., as part of a NASA Lewis Research Center Phase II Small Business Innovation Research contract, has successfully demonstrated paralleling two thermodynamically independent Stirling converters. A system of four Stirling converters is being developed by NASA and the Department of Energy as an alternative high-efficiency radioisotope power source for spacecraft onboard electric power for NASA deep space missions. The high Stirling efficiency, exceeding 20 percent for this application, will greatly reduce the necessary isotope inventory in comparison to the current radioisotope thermoelectric generators (RTG s), significantly reducing mission cost and risk. Stirling is the most developed converter option of the advanced power technologies under consideration.

  13. Primary Parallel Isolated Boost Converter with Bidirectional Operation

    DEFF Research Database (Denmark)

    Hernandez Botella, Juan Carlos; Mira Albert, Maria del Carmen; Sen, Gökhan;

    2012-01-01

    This paper presents a bidirectional dc/dc converter operated with batteries both in the input and output. Primary parallel isolated boost converter (PPIBC) with transformer series connection on the high voltage side is preferred due to its ability to handle high currents in the low voltage side....... The converter has been modeled using non-ideal components and operated without any additional circuitry for startup using a digital soft-start procedure. Simulated and measured loop gains have been compared for the validity of the model. On-the-fly current direction change has been achieved between input...... and output battery banks with a defined ramp....

  14. Pulsewidth Modulation of Neutral-Point-Clamped Indirect Matrix Converter

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Poh Chiang, Loh; Gao, Feng;

    2008-01-01

    , an indirect matrix converter is constructed by connecting a front-end bidirectional rectification stage to a conventional two-level inversion stage with no bulky capacitive or inductive energy storage connected to their intermediate dc link. Through the proper modulation and compensation of the resulting...... converter, sinusoidal input current and output voltage can be achieved with minimized rectification switching loss, rendering the indirect matrix converter as a competitive choice for interfacing the utility grid to, e.g., defense facilities that require a different frequency supply. As an improvement...

  15. On and off controlled resonant dc-dc power converter

    DEFF Research Database (Denmark)

    2015-01-01

    output voltage and connection to a converter load. The resonant DC-DC power converter further comprises a rectification circuit connected between an output of a resonant network and the output side circuit. The resonant network is configured for alternatingly being charged from the input voltage...... or current and discharged through the rectification circuit by a first controllable switch arrangement in accordance with a first switch control signal. A second controllable switch arrangement of the resonant DC-DC power converter is configured to select a first impedance characteristic of the resonant...

  16. Step-Up DC-DC Power Converter

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a step-up DC-DC power converter which comprises a primary side circuit and a secondary side circuit coupled through a galvanic isolation barrier. The primary side circuit comprises a positive and a negative input terminal for receipt of an input voltage and an input...... being charged from the input voltage and discharged to the output capacitor through the galvanic isolation barrier in accordance with a switch control signal to produce the converter output voltage. The step-up DC-DC power converter comprises an electrical short-circuit connection across the galvanic...

  17. Radiated electromagnetic emissions of DC-DC converters

    Energy Technology Data Exchange (ETDEWEB)

    Feld, L; Jussen, R; Karpinski, W; Klein, K; Sammet, J; Wlochal, M, E-mail: sammet@cern.ch [Physikalisches Institut IB, RWTH Aachen University, Aachen (Germany)

    2010-12-15

    For the CMS tracker at SLHC a new powering scheme is considered to be mandatory to allow the detector to provide at least the same performance as today at the LHC. The baseline solution of CMS foresees the use of DC-DC converters to provide larger currents with smaller losses. An important component of most converters are inductors which, however, tend to radiate the switching noise generated by the converter. The emissions of different inductors have been measured and simulated, the coil design has been optimized and noise susceptibility measurements, with present CMS hardware, have been performed. This article summarizes the results.

  18. A nonlinearity compensation method for a matrix converter drive

    DEFF Research Database (Denmark)

    Lee, Kyo-Beum; Blaabjerg, Frede

    2005-01-01

    This paper presents a new method to compensate the nonlinearities for matrix converter drives. The nonlinearities of matrix converter drives such as commutation delay, turn-on and turn-off time of the switching devices, and on-state switching device voltage drop is corrected by a new matrix...... converter model using the direction of current. The proposed method does not need any additional hardware or complicated software and it is easy to realize by applying the algorithm to the conventional vector control. The proposed compensation method is applied for high-performance induction motor drives...

  19. Conducted EMI Evaluation and Reduction in a Forward Switching Converter

    Directory of Open Access Journals (Sweden)

    Mohammad Rouhollah Yazdani

    2012-04-01

    Full Text Available In switching power converters, electromagnetic interference (EMI is produced due to the fast changes of the voltage and current. Among switching topologies used in low and medium powers, forward converter is vastly employed which needs resetting transformer core. In this paper, a forward converter with reset winding is modeled to predict conducted EMI. To evaluate the EMI model, EMI measurement results are presented. To select an optimum reset scheme from EMI viewpoint, three reset techniques are compared using experimental results. After selecting the proper reset scheme, two EMI mitigation methods are proposed and the practical EMI reduction is presented.

  20. Choosing to convert to critical access hospital status.

    Science.gov (United States)

    Dalton, Kathleen; Slifkin, Rebecca; Poley, Stephanie; Fruhbeis, Melissa

    2003-01-01

    The authors profile facilities converting to critical access hospitals (CAHs) from 1998-2000, comparing characteristics of their communities, operations, and finances to those of other small rural providers. Counties where CAHs are located are more sparsely populated, but do not have substantially different sociodemographic profiles than other rural counties. Converting hospitals' acute daily census averaged well below the statutory limit of 15, but over one-half reduced unused bed capacity to meet CAH size limitations. The average case-mix adjusted Medicare cost per case was 16-percent higher for CAH converters than for other small hospitals and their financial ratios were substantially worse, although many other operating characteristics were similar.

  1. Thyristor voltage converter in induction electric drives with microprocessor control

    Energy Technology Data Exchange (ETDEWEB)

    Braslavsky, I.; Zuzev, A.; Shilin, S. [Electric Drive Department, Urals State Technical University, Ekaterinburg (Russian Federation)

    1997-12-31

    The paper consists of some results on developed pulse model of thyristor voltage converter which is one of the most mathematically complicated unit of electric drive. The model structure and model parameter calculating method are represented. The application of the model allows to analyse stability in `locally` by the linear pulse system theory methods with talking into consideration quantise processes within the converter. Such application provides the obtaining higher accurate results comparing with the non-linear system theory approximate methods. Logarithmic frequency characteristics are used to analyse converter dynamic features and they are represented too. (orig.) 4 refs.

  2. A DSP controlled one-to-three phase matrix converter

    Energy Technology Data Exchange (ETDEWEB)

    Dubovsky, J.; Dobrucly, B; Tabacek, R.; Havrila, R. [Department of Electric Traction and Energetics Faculty of Electrical Engineering, University of Zilina (Slovakia)

    1997-12-31

    This paper deals with the theoretical analysis computer simulation and experimental results of IM fed by a one-to-three phase matrix converter which offers a unique solution for single phase electric traction applications. The proposed drive in comparison with currently used conventional drives reduces the number of power switching elements of the converter, which increases drives dependability and brings lower investment in power electronics used in drive. Further advantage is that the converter is controlled with nearly unity power factor which cuts down the operational expenses and offers higher overall performance of the drive. (orig.) 6 refs.

  3. Pulse-width modulated DC-DC power converters

    CERN Document Server

    Kazimierczuk, Marian K

    2008-01-01

    This book studies switch-mode power supplies (SMPS) in great detail. This type of converter changes an unregulated DC voltage into a high-frequency pulse-width modulated (PWM) voltage controlled by varying the duty cycle, then changes the PWM AC voltage to a regulated DC voltage at a high efficiency by rectification and filtering. Used to supply electronic circuits, this converter saves energy and space in the overall system. With concept-orientated explanations, this book offers state-of-the-art SMPS technology and promotes an understanding of the principle operations of PWM converters,

  4. Designing A Mode Converter For Use With A Gyrotron

    Science.gov (United States)

    Hoppe, Daniel J.

    1995-01-01

    Report describes process of designing corrugated, circular-cross-section length of waveguide converting input electromagnetic radiation at frequency of 34.5 GHz in TM(11) mode to output radiation in HE(11) mode. TM(11)-mode input radiation supplied by gyrotron generating continuous-wave power of 200 kW at 34.5 GHz in TE(01) mode followed by TE(01)-to-TM(11) mode converter. Together, gyrotron and mode converters constitute prototype high-power transmitter for long-distance free-space communication.

  5. New active load voltage clamp for HF-link converters

    Energy Technology Data Exchange (ETDEWEB)

    Ljusev, P.; Andersen, M.A.E.

    2005-07-01

    This paper proposes a new active clamp for HF-link converters, which features very high efficiency by returning the clamped energy back to the primary side through a small auxiliary converter. It also increases the reliability of HF-link converters by providing an alternative load current path during malfunctions of the secondary bidirectional bridge. The feasibility of the approach is shown on audio power amplifier prototype. New integrated magnetics design is presented that incorporates both the main power and auxiliary transformer on the same magnetic core. (au)

  6. Nonlinear Phenomena in Buck-Boost Power Factor Correction Converter

    Directory of Open Access Journals (Sweden)

    Mehrnoosh Vatani

    2013-01-01

    Full Text Available Buck-Boost Power-Factor-Correction (PFC converter with Average-Current-Model (ACM control is a nonlinear circuit because of the multiplier using and large change in the duty cycle, so its stability analysis must be studied by nonlinear model. In this paper double averaging method is used for describing the model of this converter. By this model we would be able to explain the low frequency dynamics of the system and identify stability boundaries according to circuit parameters and also nonlinear phenomena of this converter are detected.

  7. Improving EMI Attenuation in Frequency Modulated Power Converters

    OpenAIRE

    Stepins, D.

    2009-01-01

    The effect of frequency modulation on a power switching converter electromagnetic interference (EMI) attenuation is examined in this paper. A method known as “modified sawtooth” is applied for EMI attenuation in a boost converter and it is optimized in such a way to reduce EMI more effectively. The method is also verified experimentally by the use of a low power boost converter controlled via an arbitrary waveform generator. EMI attenuation up to 15 dB is achieved after using modified sawtoot...

  8. Atomic Electronic Contract Protocol Based on Convertible Signature

    Institute of Scientific and Technical Information of China (English)

    LIU Yi-chun; WANG Li-na; ZHANG Huan-guo

    2005-01-01

    A new class of atomicity, namely contract atomicity is presented. A new technical strategy based on convertible signature and two-phase commitment is proposed for implementing atomicity of electronic contract protocol. A new atomic contract signing protocol is given out by using ElGamal-like convertible undeniable signature and commitment of conversion key, and another new atomic contract signing protocol is brought forward by using RSA-based convertible undeniable signature scheme and commitment of conversion key.These two new protocols are proved to be of atomicity, fairness, privacy, non-repudiation.

  9. Ultrathin flexible terahertz polarization converter based on metasurfaces.

    Science.gov (United States)

    Mo, Weicheng; Wei, Xuli; Wang, Kejia; Li, Yao; Liu, Jinsong

    2016-06-13

    We present a method to design and fabricate a kind of converters based on flexible metasurfaces which can change the polarization state of an incident terahertz beam. The metasurface consists of a two-dimensional array of rectangular metallic antennas that can abruptly change the phase of the incoming terahertz beam. Experimentally demonstrated half-wave plates generate 0.1 THz beam with a π/2 polarization rotation. By slightly changing the structure of the converter, an elliptically or circularly polarized beam is expected to be obtained. These flexible terahertz converters may have many potential applications in terahertz technology. PMID:27410377

  10. Design and operation of a thermionic converter in air

    International Nuclear Information System (INIS)

    An electrically heated thermionic converter has been designed, built and successfully tested in air. Several unique features were incorporated in this converter: an integral cesium reservoir, innovative ceramic-to-metal seals, a heat rejection system coupling the collector to a low temperature heat sink and an innovative cylindrical heater filament. The converter was operated for extended periods of time with the emitter at about 1900 K. the collector at about 700 K, and a power density of over 2 w(e)/sq. cm. Input power transients were run between 50% and 100% thermal power, at up to 1% per second, without instabilities in performance

  11. High Voltage Power Converter for Large Wind Turbine

    DEFF Research Database (Denmark)

    Sztykiel, Michal

    application. System B consists of the generator-side 2-level converter, DC/DC boost unit and a grid-side NPC-3L converter. System C is made of a seriesconnected full-bridge cells on the generator-side, and a grid-side NPC-5L converter. The performance of the proposed topologies is analyzed both under...... also for different grounding schemes, which impact is the result of the removed step-up transformer. Finally, the ground fault detection scheme for feeder cable system is proposed - with the usage of current differential relay. Due to lack of the galvanic separation between the wind turbines...

  12. Sliding mode control of switching power converters techniques and implementation

    CERN Document Server

    Tan, Siew-Chong; Tse, Chi-Kong

    2011-01-01

    Sliding Mode Control of Switching Power Converters: Techniques and Implementation is perhaps the first in-depth account of how sliding mode controllers can be practically engineered to optimize control of power converters. A complete understanding of this process is timely and necessary, as the electronics industry moves toward the use of renewable energy sources and widely varying loads that can be adequately supported only by power converters using nonlinear controllers.Of the various advanced control methods used to handle the complex requirements of power conversion systems, sliding mode c

  13. Creatine kinase activity is associated with blood pressure

    NARCIS (Netherlands)

    L.M. Brewster; G. Mairuhu; N.R. Bindraban; R.P. Koopmans; J.F. Clark; G.A. van Montfrans

    2006-01-01

    Background - We previously hypothesized that high activity of creatine kinase, the central regulatory enzyme of energy metabolism, facilitates the development of high blood pressure. Creatine kinase rapidly provides adenosine triphosphate to highly energy-demanding processes, including cardiovascula

  14. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1

    DEFF Research Database (Denmark)

    Jensen, Claus Antonio Juel; Buch, M B; Krag, T O;

    1999-01-01

    90-kDa ribosomal S6 kinase-2 (RSK2) belongs to a family of growth factor-activated serine/threonine kinases composed of two kinase domains connected by a regulatory linker region. The N-terminal kinase of RSK2 is involved in substrate phosphorylation. Its activation requires phosphorylation of th...... of Ser(227), Ser(369), and Ser(386). Our study extend recent findings which implicate PDK1 in the activation of protein kinases B and C and p70(S6K), suggesting that PDK1 controls several major growth factor-activated signal transduction pathways.......90-kDa ribosomal S6 kinase-2 (RSK2) belongs to a family of growth factor-activated serine/threonine kinases composed of two kinase domains connected by a regulatory linker region. The N-terminal kinase of RSK2 is involved in substrate phosphorylation. Its activation requires phosphorylation...... of the linker region at Ser(369), catalyzed by extracellular signal-regulated kinase (ERK), and at Ser(386), catalyzed by the C-terminal kinase, after its activation by ERK. In addition, the N-terminal kinase must be phosphorylated at Ser(227) in the activation loop by an as yet unidentified kinase. Here, we...

  15. Pink1, the first ubiquitin kinase

    OpenAIRE

    Zheng, Xinde; Hunter, Tony

    2014-01-01

    Pink1 and Parkin, identified through studies of hereditary early onset Parkinson's disease, are involved in mitochondria quality control. Parkin E3 ubiquitin ligase activity is activated by Pink1 kinase activity, although the mechanism is still elusive. Three recent reports uncover a surprising mechanism in which Pink1 directly phosphorylates ubiquitin to boost Parkin activity.

  16. The IKK Kinases: Operators of Antiviral Signaling

    Directory of Open Access Journals (Sweden)

    Alissa M. Pham

    2010-01-01

    Full Text Available The ability of a cell to combat an intracellular pathogen requires a mechanism to recognize the threat and elicit a transcriptional response against it. In the context of virus infection, the cell must take measures to inhibit viral replication, meanwhile, convey warning signals to neighboring cells of the imminent threat. This immune response is predominantly mediated by the production of cytokines, notably, interferon beta (IFNβ. IFNβ signaling results in the transcriptional induction of over one hundred antiviral gene products whose timely expression renders infected cells more capable of inhibiting virus replication, while providing the uninfected cells with the reinforcements to generate a less permissive cellular environment. Induction of IFNβ and many aspects of the antiviral response pivot on the function of the IKK and IKK-related kinases. Despite sharing high levels of homology and some degree of functional redundancy, the classic IKK kinases: IKKα and IKKβ, and the IKK-related kinases: TBK1 and IKKε, perform distinct roles in regulating the host antiviral defense. These kinases serve as molecular operators in their cooperative ability to integrate incoming cellular cues and act on a range of essential antiviral transcription factors to reshape the cellular transcriptome during infection.

  17. Periodic fever and mevalonate kinase deficiency

    NARCIS (Netherlands)

    Frenkel, Joost

    2002-01-01

    Mevalonate kinase (MK) deficiency is an autosomal recessive disorder, caused by mutations in the MVK-gene on chromosome 12q24. The affected enzyme catalyzes an early step in isoprenoid biosynthesis, the pathway that produces cholesterol and several non-sterol isoprenoids. The clinical spectrum inclu

  18. Discovery of inhibitors of bacterial histidine kinases

    NARCIS (Netherlands)

    Velikova, N.R.

    2014-01-01

    Discovery of Inhibitors of Bacterial Histidine Kinases

    Summary

    The thesis is on novel antibacterial drug discovery (http://youtu.be/NRMWOGgeysM). Using structure-based and fragment-based dru

  19. Soft switching buck-boost converter for photovoltaic power generation; Taiyoko hatsuden no tame no soft switching shokoatsu converter

    Energy Technology Data Exchange (ETDEWEB)

    Lee, H. [Kyungnam University (Korea, Republic of)

    1996-10-27

    A soft switching method with small switching loss was proposed for the purpose of increasing the efficiency of a DC-DC boost converter which converted a DC current generated by solar cells to a variable DC current. Existing current converters are supplemented by using a snubber circuit around the switch so as to protect the switch by a hard switching action. However, with an increase of the output current, snubber loss is increased, reducing the efficiency. In order to solve this problem, the partial resonant switch method was applied to the converter; with this method of partially forming a resonant circuit only at the time of turning on/off of the switch, the switching loss was reduced through the soft switching, thereby making the proposed converter operate with high efficiency. Moreover, the resonant element of the partial resonant circuit using a snubber condenser, the energy accumulated in the condenser was regenerated on the power supply side without loss of snubber. With the regenerated energy, the proposed converter was provided with a smaller ratio of switching to use than the conventional converter. 4 refs., 7 figs., 1 tab.

  20. p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo.

    Science.gov (United States)

    Canault, Matthias; Duerschmied, Daniel; Brill, Alexander; Stefanini, Lucia; Schatzberg, Daphne; Cifuni, Stephen M; Bergmeier, Wolfgang; Wagner, Denisa D

    2010-03-01

    Platelets undergo several modifications during storage that reduce their posttransfusion survival and functionality. One important feature of these changes, which are known as platelet storage lesion, is the shedding of the surface glycoproteins GPIb-alpha and GPV. We recently demonstrated that tumor necrosis factor-alpha converting enzyme (TACE/ADAM17) mediates mitochondrial injury-induced shedding of adhesion receptors and that TACE activity correlates with reduced posttransfusion survival of these cells. We now confirm that TACE mediates receptor shedding and clearance of platelets stored for 16 hours at 37 degrees C or 22 degrees C. We further demonstrate that both storage and mitochondrial injury lead to the phosphorylation of p38 mitogen-activated kinase (MAPK) in platelets and that TACE-mediated receptor shedding from mouse and human platelets requires p38 MAP kinase signaling. Protein kinase C, extracellular regulated-signal kinase MAPK, and caspases were not involved in TACE activation. Both inhibition of p38 MAPK and inactivation of TACE during platelet storage led to a markedly improved posttransfusion recovery and hemostatic function of platelets in mice. p38 MAPK inhibitors had only minor effects on the aggregation of fresh platelets under static or flow conditions in vitro. In summary, our data suggest that inhibition of p38 MAPK or TACE during storage may significantly improve the quality of stored platelets.

  1. Kinase detection with gallium nitride based high electron mobility transistors.

    Science.gov (United States)

    Makowski, Matthew S; Bryan, Isaac; Sitar, Zlatko; Arellano, Consuelo; Xie, Jinqiao; Collazo, Ramon; Ivanisevic, Albena

    2013-07-01

    A label-free kinase detection system was fabricated by the adsorption of gold nanoparticles functionalized with kinase inhibitor onto AlGaN/GaN high electron mobility transistors (HEMTs). The HEMTs were operated near threshold voltage due to the greatest sensitivity in this operational region. The Au NP/HEMT biosensor system electrically detected 1 pM SRC kinase in ionic solutions. These results are pertinent to drug development applications associated with kinase sensing.

  2. CK2: a protein kinase in need of control

    DEFF Research Database (Denmark)

    Guerra, B; Boldyreff, B; Sarno, S;

    1999-01-01

    Protein kinase CK2 is a heterotetrameric alpha2beta2 Ser/Thr protein kinase with some features unusual among the eukaryotic protein kinases: (1) CK2 recognizes phosphoacceptor sites specified by several acidic determinants; (2) CK2 can use both ATP and GTP as phosphoryl donors; and (3...... response to nucleotide analogs. The increasing knowledge of CK2 structure-function relationships will allow the design of highly selective inhibitors of this pleiotropic kinase with oncogenic potential....

  3. New Class of Competitive Inhibitor of Bacterial Histidine Kinases

    OpenAIRE

    Gilmour, Raymond; Foster, J. Estelle; Sheng, Qin; McClain, Jonathan R.; Riley, Anna; Sun, Pei-Ming; Ng, Wai-Leung; Yan, Dalai; Nicas, Thalia I.; Henry, Kenneth; Winkler, Malcolm E.

    2005-01-01

    Bacterial histidine kinases have been proposed as targets for the discovery of new antibiotics, yet few specific inhibitors of bacterial histidine kinases have been reported. We report here a novel thienopyridine (TEP) compound that inhibits bacterial histidine kinases competitively with respect to ATP but does not comparably inhibit mammalian serine/threonine kinases. Although it partitions into membranes and does not inhibit the growth of bacterial or mammalian cells, TEP could serve as a s...

  4. Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

    Science.gov (United States)

    Anderson, David R; Meyers, Marvin J; Vernier, William F; Mahoney, Matthew W; Kurumbail, Ravi G; Caspers, Nicole; Poda, Gennadiy I; Schindler, John F; Reitz, David B; Mourey, Robert J

    2007-05-31

    A new class of potent kinase inhibitors selective for mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) for the treatment of rheumatoid arthritis has been prepared and evaluated. These inhibitors have IC50 values as low as 10 nM against the target and have good selectivity profiles against a number of kinases including CDK2, ERK, JNK, and p38. These MK-2 inhibitors have been shown to suppress TNFalpha production in U397 cells and to be efficacious in an acute inflammation model. The structure-activity relationships of this series, the selectivity for MK-2 and their activity in both in vitro and in vivo models are discussed. The observed selectivity is discussed with the aid of an MK-2/inhibitor crystal structure.

  5. Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies.

    Directory of Open Access Journals (Sweden)

    Westa Domanova

    Full Text Available In response to stimuli, biological processes are tightly controlled by dynamic cellular signaling mechanisms. Reversible protein phosphorylation occurs on rapid time-scales (milliseconds to seconds, making it an ideal carrier of these signals. Advances in mass spectrometry-based proteomics have led to the identification of many tens of thousands of phosphorylation sites, yet for the majority of these the kinase is unknown and the underlying network topology of signaling networks therefore remains obscured. Identifying kinase substrate relationships (KSRs is therefore an important goal in cell signaling research. Existing consensus sequence motif based prediction algorithms do not consider the biological context of KSRs, and are therefore insensitive to many other mechanisms guiding kinase-substrate recognition in cellular contexts. Here, we use temporal information to identify biologically relevant KSRs from Large-scale In Vivo Experiments (KSR-LIVE in a data-dependent and automated fashion. First, we used available phosphorylation databases to construct a repository of existing experimentally-predicted KSRs. For each kinase in this database, we used time-resolved phosphoproteomics data to examine how its substrates changed in phosphorylation over time. Although substrates for a particular kinase clustered together, they often exhibited a different temporal pattern to the phosphorylation of the kinase. Therefore, although phosphorylation regulates kinase activity, our findings imply that substrate phosphorylation likely serve as a better proxy for kinase activity than kinase phosphorylation. KSR-LIVE can thereby infer which kinases are regulated within a biological context. Moreover, KSR-LIVE can also be used to automatically generate positive training sets for the subsequent prediction of novel KSRs using machine learning approaches. We demonstrate that this approach can distinguish between Akt and Rps6kb1, two kinases that share the same

  6. Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies

    Science.gov (United States)

    Chaudhuri, Rima; Yang, Pengyi; Vafaee, Fatemeh; Fazakerley, Daniel; Humphrey, Sean; James, David; Kuncic, Zdenka

    2016-01-01

    In response to stimuli, biological processes are tightly controlled by dynamic cellular signaling mechanisms. Reversible protein phosphorylation occurs on rapid time-scales (milliseconds to seconds), making it an ideal carrier of these signals. Advances in mass spectrometry-based proteomics have led to the identification of many tens of thousands of phosphorylation sites, yet for the majority of these the kinase is unknown and the underlying network topology of signaling networks therefore remains obscured. Identifying kinase substrate relationships (KSRs) is therefore an important goal in cell signaling research. Existing consensus sequence motif based prediction algorithms do not consider the biological context of KSRs, and are therefore insensitive to many other mechanisms guiding kinase-substrate recognition in cellular contexts. Here, we use temporal information to identify biologically relevant KSRs from Large-scale In Vivo Experiments (KSR-LIVE) in a data-dependent and automated fashion. First, we used available phosphorylation databases to construct a repository of existing experimentally-predicted KSRs. For each kinase in this database, we used time-resolved phosphoproteomics data to examine how its substrates changed in phosphorylation over time. Although substrates for a particular kinase clustered together, they often exhibited a different temporal pattern to the phosphorylation of the kinase. Therefore, although phosphorylation regulates kinase activity, our findings imply that substrate phosphorylation likely serve as a better proxy for kinase activity than kinase phosphorylation. KSR-LIVE can thereby infer which kinases are regulated within a biological context. Moreover, KSR-LIVE can also be used to automatically generate positive training sets for the subsequent prediction of novel KSRs using machine learning approaches. We demonstrate that this approach can distinguish between Akt and Rps6kb1, two kinases that share the same linear consensus motif

  7. Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies.

    Science.gov (United States)

    Domanova, Westa; Krycer, James; Chaudhuri, Rima; Yang, Pengyi; Vafaee, Fatemeh; Fazakerley, Daniel; Humphrey, Sean; James, David; Kuncic, Zdenka

    2016-01-01

    In response to stimuli, biological processes are tightly controlled by dynamic cellular signaling mechanisms. Reversible protein phosphorylation occurs on rapid time-scales (milliseconds to seconds), making it an ideal carrier of these signals. Advances in mass spectrometry-based proteomics have led to the identification of many tens of thousands of phosphorylation sites, yet for the majority of these the kinase is unknown and the underlying network topology of signaling networks therefore remains obscured. Identifying kinase substrate relationships (KSRs) is therefore an important goal in cell signaling research. Existing consensus sequence motif based prediction algorithms do not consider the biological context of KSRs, and are therefore insensitive to many other mechanisms guiding kinase-substrate recognition in cellular contexts. Here, we use temporal information to identify biologically relevant KSRs from Large-scale In Vivo Experiments (KSR-LIVE) in a data-dependent and automated fashion. First, we used available phosphorylation databases to construct a repository of existing experimentally-predicted KSRs. For each kinase in this database, we used time-resolved phosphoproteomics data to examine how its substrates changed in phosphorylation over time. Although substrates for a particular kinase clustered together, they often exhibited a different temporal pattern to the phosphorylation of the kinase. Therefore, although phosphorylation regulates kinase activity, our findings imply that substrate phosphorylation likely serve as a better proxy for kinase activity than kinase phosphorylation. KSR-LIVE can thereby infer which kinases are regulated within a biological context. Moreover, KSR-LIVE can also be used to automatically generate positive training sets for the subsequent prediction of novel KSRs using machine learning approaches. We demonstrate that this approach can distinguish between Akt and Rps6kb1, two kinases that share the same linear consensus motif

  8. A NEW DESIGN of SIX- PHASE ROTARY CONVERTER ELECTRIC MACHINE

    Directory of Open Access Journals (Sweden)

    K. G. Mohammed

    2012-12-01

    Full Text Available The aim of this research is to design a new ac rotary converter machine to convert the ac single phase voltage to six-phase voltages by using multi stages energy conversion machine. The rotary converter is composed from two main stages and is combined into one frame. These two stages are formed from three main electromagnetic components. The first component represents the input stage that enables the energy from single phase to enter and transformed by the second and third components electro-magnetically to produce six-phase voltages which at the output stage. The programs are created using MATLAB in order to calculate the required dimensions of the converter machine and its parameters for magnetic and electrical circuits.

  9. Polarization converters on double hetero structures containing strained quantum wells

    Science.gov (United States)

    Khalique, U.; van der Tol, J. J. G. M.; Nötzel, R.; Smit, M. K.

    2009-02-01

    The importance of polarization manipulation is increased as optical fiber systems evolve to higher data rates. Photonic integrated circuits should be insensitive to the state of polarization of the light emanating from fibers if they are to be used as detectors, add-drop mutiplexers or cross connects. Either all the integrated components have to be polarization independent or only one polarization direction should be used. For either method, a compact polarization converter is useful. A model is developed for the mode propagation in the waveguide of the slanted side polarization converter based on double hetero structures. The model is extended to include polarization dependent absorption and mismatch. Polarization converters on different double heterostructures (with and without quantum wells) have been designed and are realized by contact optical lithography. The performance of the realized converters is well described with the model.

  10. A New Asymmetrical Current-fed Converter with Voltage Lifting

    Directory of Open Access Journals (Sweden)

    DELSHAD, M.

    2011-05-01

    Full Text Available This paper presents a new zero voltage switching current-fed DC-DC converter with high voltage gain. In this converter all switches (main and auxiliary turn on under zero voltage switching and turn off under almost zero voltage switching due to snubber capacitor. Furthermore, the voltage spike across the main switch due to leakage inductance of forward transformer is absorbed. The flyback transformer which is connected to the output in series causes to high voltage gain and less voltage stress on the power devices. Considering high efficiency and voltage gain of this converter, it is suitable for green generated systems such as fuel cells or photovoltaic systems. The presented experimental results verify the integrity of the proposed converter.

  11. Effects of cavitation on performance of automotive torque converter

    Directory of Open Access Journals (Sweden)

    Jaewon Ju

    2016-06-01

    Full Text Available Cavitation is a phenomenon whereby vapor bubbles of a flowing liquid are formed in a local region where the pressure of the liquid is below its vapor pressure. It is well known that cavitation in torque converters occurs frequently when a car with an automatic transmission makes an abrupt start. Cavitation is closely related to a performance drop and noise generation at a specific operating condition in a car and a torque converter itself. This study addressed the relation between cavitation and performance in an automotive torque converter in a quantitative and qualitative manner using numerical simulations. The cavitation was calculated at various operating conditions using a commercial flow solver with the homogeneous cavitation model, and the torque converter performance was compared with the experimental data. Numerical results well match to the data and indicate that the cavitation causes significant performance drop, as the pump speed increases or both speed ratio and reference pressure decrease.

  12. Single Phase Bidirectional PWM Converter for Microgrid System

    Directory of Open Access Journals (Sweden)

    C.Kalavalli

    2013-06-01

    Full Text Available Smart grid is a newly flourishing research area because of its viable applications and expected to address the drawback of existing grid. Microgrids are the part of the Smart grid and they are designed to supply electricity for a small community such as residential areas, universities or industrial sites. Power electronics plays a vital role for connecting the renewable energy sources to Microgrid system. This paper deals the Microgrid connected single phase Bidirectional PWM converter which operates in Rectification and Inverting mode. This converter helps to connect renewable energy sources to loads as well as excess power are given to power grid. Double Loop PID control technique is used for controlling the converter for both modes. The designed Converter is simulated in MATLAB/Simulink software and results are verified using the Hardware.

  13. Power electronic converters and systems frontiers and applications

    CERN Document Server

    Trzynadlowski, Andrzej M

    2016-01-01

    Power electronics is a branch of electrical engineering dealing with conversion and control of electric power using semiconductor power switches. This book provides an overview of modern power electronic converters and systems, and their applications.

  14. Research on optical biosensor with up-converting phosphor marker

    Institute of Scientific and Technical Information of China (English)

    Yongkai Zhao; Xiangzhao Wang; Lei Zhou; Jing Wang; Lihua Huang; Zhongqiang Yan; Huijie Huang; Ruifu Yang; Lei Liu; Bingqiang Ren

    2006-01-01

    @@ An optical biosensor with up-converting phosphor (UCP) marker is developed for the sensitive rapid immunoassay to the specific biomolecule. UCP can emit visible light when excited by infrared light.

  15. Three Phase Resonant DC Power Converter for Ion Thrusters Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Our phase 1 study has revealed many significant benefits of a new class of DC-to-DC power converters with performance that cannot be matched by current flight power...

  16. Systematic risk variations (beta convertible debenture brazilian companies

    Directory of Open Access Journals (Sweden)

    Renata Drumond Pinto Coelho Antonino

    2010-01-01

    Full Text Available purpose of this article is to analyze the impact of issuing convertible debentures on the systematic risk of Brazilian companies. Some applied researches in the U.S. capital market (STEIN, 1992; LEWIS et al, 2002; RAI, 2005 indicate that convertible debentures may be used as an alternative financing source when adverse selection problem makes stock issuing unattractive financing source. The analysis of Brazilian companies that issued convertible debentures recorded in the period from 1998 to 2006 and that presented liquidity on the market indicated that variation in beta, on average, is positive. These results are coherent with the signaling hypothesis and with the absence of convertible debenture issuing in 2005 and 2006 on the Brazilian market. They also may be related to the precarious financial situation of issuing companies, observed by the analysis of some financial indicators in year of issue and in two pre- e post-issuing years.

  17. A Proficient AC/DC Converter with Power Factor Correction

    Directory of Open Access Journals (Sweden)

    Shakh Md. Alimuzjaman Alim

    2016-08-01

    Full Text Available Dc power supplies are extensively used inside most of electrical and electronic appliances such as in computers, televisions, audio sets and others. Power supplies make the load compatible with its power source. The presence of nonlinear loads results into low power factor operation of the power system. Several techniques for power factor correction and harmonic reduction have been reported and a few of them have gained greater acceptance over the others. In this paper a bridgeless power factor correction boost converter is proposed which results in improved power factor and reduced harmonics content in input line currents as compared to conventional boost converter topology. Bridgeless power factor correction boost converter eliminates the linevoltage bridge rectifier in conventional boost power factor correction converter, so that the conduction loss is reduced.

  18. Visceral Angioedema Induced by Angiotensin Converting Enzyme Inhibitor: Case Report

    Directory of Open Access Journals (Sweden)

    Beatriz Frutuoso

    2016-05-01

    Conclusion: The diagnosis of intestinal angioedema induced by angiotensin converting enzyme inhibitor can be challenging and time consuming due to its rarity and nonspecific symptoms, which may lead to underdiagnosis of this entity.

  19. Translator program converts computer printout into braille language

    Science.gov (United States)

    Powell, R. A.

    1967-01-01

    Computer program converts print image tape files into six dot Braille cells, enabling a blind computer programmer to monitor and evaluate data generated by his own programs. The Braille output is printed 8 lines per inch.

  20. High Input Voltage Hall Thruster Discharge Converter Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The overall scope of this Phase I/II effort is the development of a high efficiency 15kW (nominal) Hall thruster discharge converter. In Phase I, Busek Co. Inc....