WorldWideScience

Sample records for cexternal beam radiation

  1. cExternal beam radiation results in minimal changes in post void residual urine volumes during the treatment of clinically localized prostate cancer

    Directory of Open Access Journals (Sweden)

    Wallner Kent E

    2009-07-01

    Full Text Available Abstract Background To evaluate the impact of external beam radiation therapy (XRT on weekly ultrasound determined post-void residual (PVR urine volumes in patients with prostate cancer. Methods 125 patients received XRT for clinically localized prostate cancer. XRT was delivered to the prostate only (n = 66 or if the risk of lymph node involvement was greater than 10% to the whole pelvis followed by a prostate boost (n = 59. All patients were irradiated in the prone position in a custom hip-fix mobilization device with an empty bladder and rectum. PVR was obtained at baseline and weekly. Multiple clinical and treatment parameters were evaluated as predictors for weekly PVR changes. Results The mean patient age was 73.9 years with a mean pre-treatment prostate volume of 53.3 cc, a mean IPSS of 11.3 and a mean baseline PVR of 57.6 cc. During treatment, PVR decreased from baseline in both cohorts with the absolute difference within the limits of accuracy of the bladder scanner. Alpha-blockers did not predict for a lower PVR during treatment. There was no significant difference in mean PVR urine volumes or differences from baseline in either the prostate only or pelvic radiation groups (p = 0.664 and p = 0.458, respectively. Patients with a larger baseline PVR (>40 cc had a greater reduction in PVR, although the greatest reduction was seen between weeks one and three. Patients with a small PVR ( Conclusion Prostate XRT results in clinically insignificant changes in weekly PVR volumes, suggesting that radiation induced bladder irritation does not substantially influence bladder residual urine volumes.

  2. cExternal beam radiation results in minimal changes in post void residual urine volumes during the treatment of clinically localized prostate cancer

    International Nuclear Information System (INIS)

    To evaluate the impact of external beam radiation therapy (XRT) on weekly ultrasound determined post-void residual (PVR) urine volumes in patients with prostate cancer. 125 patients received XRT for clinically localized prostate cancer. XRT was delivered to the prostate only (n = 66) or if the risk of lymph node involvement was greater than 10% to the whole pelvis followed by a prostate boost (n = 59). All patients were irradiated in the prone position in a custom hip-fix mobilization device with an empty bladder and rectum. PVR was obtained at baseline and weekly. Multiple clinical and treatment parameters were evaluated as predictors for weekly PVR changes. The mean patient age was 73.9 years with a mean pre-treatment prostate volume of 53.3 cc, a mean IPSS of 11.3 and a mean baseline PVR of 57.6 cc. During treatment, PVR decreased from baseline in both cohorts with the absolute difference within the limits of accuracy of the bladder scanner. Alpha-blockers did not predict for a lower PVR during treatment. There was no significant difference in mean PVR urine volumes or differences from baseline in either the prostate only or pelvic radiation groups (p = 0.664 and p = 0.458, respectively). Patients with a larger baseline PVR (>40 cc) had a greater reduction in PVR, although the greatest reduction was seen between weeks one and three. Patients with a small PVR (<40 cc) had no demonstrable change throughout treatment. Prostate XRT results in clinically insignificant changes in weekly PVR volumes, suggesting that radiation induced bladder irritation does not substantially influence bladder residual urine volumes

  3. Cyclotron radiation beam control

    International Nuclear Information System (INIS)

    This patent application describes an apparatus for attenuating a beam of particulate radiation comprising a series of modules, each module being constituted by a sphere having a passage, a cupola covering said sphere and a base supporting said sphere, and means for causing movement of the spheres for aligning said passages with an axis of a beam line and arranging said passages out of alignment so as to attenuate the beam. (author)

  4. Beam diagnostics with synchrotron radiation

    International Nuclear Information System (INIS)

    Synchrotron radiation is often used to measure the dimensions of an electron beam. The transverse size is obtained from an image of the beam cross section formed by means of the emitted synchrotron radiation. Because of the small natural opening angle the resolution is limited by diffraction. The angular spread of the particles in the beam can be measured by observing the radiation directly. Here, the resolution is limited by the natural opening angle of the emitted light. Measuring both beam cross section and angular spread gives the emittance of the beam. However, in most cases only one of these two parameters is observed and the other deduced from the known particle beam optics at the source of the radiation. Usually one observes radiation emitted in long bending magnets. However, short magnets and undulators are also useful sources for these measurements. For practical reasons the beam diagnostics is carried out using visible or ultraviolet light. This part of the spectrum is usually far below the critical frequency, and corresponding approximations can be applied. Synchrotron radiation is an extremely useful tool for diagnostics in electron (or positron) rings. In some cases it has also served in proton rings using special magnets. (author)

  5. Emittance in particle and radiation beam techniques

    International Nuclear Information System (INIS)

    The author discusses the important and diverse role of the phase space area - the emittance - in the advanced techniques involving interaction of particle and radiation beams. For undulator radiation from unbunched beams, the radiation phase space is diluted from the coherent phase space of the single electron radiation. When the undulator radiation is used as a light source, it is important to minimize the dilution by decreasing the beam emittance and matching the phase space distributions of the particle and the radiation beams. For optical stochastic cooling, on the other hand, the phase space should be maximally mismatched for efficient cooling. In the case particles are bunched to a length much shorter than the radiation wavelength, the emittance appears as an intensity enhancement factor. In the operation of free electron lasers, the phase space matching becomes doubly important, once as the dilution factor in the initial stage of energy modulation and then as the radiation efficiency factor at the end where the beam is density modulated. The author then discusses some of the beam cooling techniques producing smaller emittances, especially the recent suggestions for relativistic heavy ions in storage rings or electron beams in linacs. These are based on the radiative cooling that occurs when particle beams backscatter powerful laser beams

  6. Radiation therapy apparatus having retractable beam stopper

    International Nuclear Information System (INIS)

    This invention relates to a radiation therapy apparatus which utilized a linear translation mechanism for positioning a beam stopper. An apparatus is described wherein the beam stopper is pivotally attached to the therapy machine with an associated drive motor in such a way that the beam stopper retracts linearly

  7. Radiation dermatitis following electron beam therapy

    International Nuclear Information System (INIS)

    Ten patients, who had been treated for mycosis fungoides with electron beam radiation ten or more years previously, were examined for signs of radiation dermatitis. Although most patients had had acute radiation dermatitis, only a few manifested signs of mild chronic changes after having received between 1,000 and 2,800 rads

  8. Electron beams in radiation therapy

    International Nuclear Information System (INIS)

    Clinical electron beams in interaction with beam flattening and collimating devices are studied, in order to obtain the means for adequate electron therapy. A treatment planning method for arbitrary field shapes is developed that takes the properties of the collimated electron beams into account. An electron multiple-scattering model is extended to incorporate a model for the loss of electrons with depth, in order to improve electron beam dose planning. A study of ionisation measurements in two different phantom materials yields correction factors for electron beam dosimetry. (Auth.)

  9. Electron beam instrumentation techniques using coherent radiation

    International Nuclear Information System (INIS)

    Much progress has been made on coherent radiation research since coherent synchrotron radiation was first observed in 1989. The use of coherent radiation as a bunch length diagnostic tool has been studied by several groups. In this paper, brief introductions to coherent radiation and far-infrared measurement are given, the progress and status of their beam diagnostic application are reviewed, different techniques are described, and their advantages and limitations are discussed

  10. ALICE Transition Radiation Detector (TRD), test beam.

    CERN Multimedia

    2003-01-01

    Electrons and positrons can be discriminated from other charged particles using the emission of transition radiation - X-rays emitted when the particles cross many layers of thin materials. To develop such a Transition Radiation Detector(TRD) for ALICE many detector prototypes were tested in mixed beams of pions and electrons, as in the example shown here.

  11. Coherent radiation by short bunch electron beam

    International Nuclear Information System (INIS)

    The electron beam which is accelerated with a linear accelerator forms the bunch of which the length in advancing direction is several millimeter. The radiation in far infrared region and transition radiation emitted from it are the coherent radiation, in which the phase of the radiation components from many electrons are uniform. Consequently, the intensity increases remarkably. By using this, the research on the properties of transition radiation of long wavelength and Cherenkov radiation which were unknown so far because those are weak was carried out. The radiation like this is not only powerful light source, but also it can be utilized to measure the shape of the bunch of accelerated particles. The coherent effect and the intensity of coherent radiation are explained. The spectra and the intensity distribution, the interference of coherent light, the properties of transition radiation, the formation layer of Cherenkov radiation from finite tracks and so on are reported. The measurement of the shape of bunch was carried out, and line-shaped beam and laterally extended beam are explained. The application as light source is reported. (K.I.)

  12. Radiative trapping in intense laser beams

    Science.gov (United States)

    Kirk, J. G.

    2016-08-01

    The dynamics of electrons in counter-propagating, circularly polarized laser beams are shown to exhibit attractors whose ability to trap particles depends on the ratio of the beam intensities and a single parameter describing radiation reaction. Analytical expressions are found for the underlying limit cycles and the parameter range in which they are stable. In high-intensity optical pulses, where radiation reaction strongly modifies the trajectories, the production of collimated gamma-rays and the initiation of non-linear cascades of electron–positron pairs can be optimized by a suitable choice of the intensity ratio.

  13. Radiative trapping in intense laser beams

    CERN Document Server

    Kirk, J G

    2016-01-01

    The dynamics of electrons in counter-propagating, circularly polarized laser beams are shown to exhibit attractors whose ability to trap particles depends on the ratio of the beam intensities and a single parameter describing radiation reaction. Analytical expressions are found for the underlying limit cycles and the parameter range in which they are stable. In high-intensity optical pulses, where radiation reaction strongly modifies the trajectories, the production of collimated gamma-rays and the initiation of non-linear cascades of electron-positron pairs can be optimized by a suitable choice of the intensity ratio.

  14. Radiative cooling of relativistic electron beams

    International Nuclear Information System (INIS)

    Modern high-energy particle accelerators and synchrotron light sources demand smaller and smaller beam emittances in order to achieve higher luminosity or better brightness. For light particles such as electrons and positrons, radiation damping is a natural and effective way to obtain low emittance beams. However, the quantum aspect of radiation introduces random noise into the damped beams, yielding equilibrium emittances which depend upon the design of a specific machine. In this dissertation, the author attempts to make a complete analysis of the process of radiation damping and quantum excitation in various accelerator systems, such as bending magnets, focusing channels and laser fields. Because radiation is formed over a finite time and emitted in quanta of discrete energies, he invokes the quantum mechanical approach whenever the quasiclassical picture of radiation is insufficient. He shows that radiation damping in a focusing system is fundamentally different from that in a bending system. Quantum excitation to the transverse dimensions is absent in a straight, continuous focusing channel, and is exponentially suppressed in a focusing-dominated ring. Thus, the transverse normalized emittances in such systems can in principle be damped to the Compton wavelength of the electron, limited only by the Heisenberg uncertainty principle. In addition, he investigates methods of rapid damping such as radiative laser cooling. He proposes a laser-electron storage ring (LESR) where the electron beam in a compact storage ring repetitively interacts with an intense laser pulse stored in an optical resonator. The laser-electron interaction gives rise to rapid cooling of electron beams and can be used to overcome the space charge effects encountered in a medium energy circular machine. Applications to the designs of low emittance damping rings and compact x-ray sources are also explored

  15. Development of 'Beam Color' radiation indicators

    International Nuclear Information System (INIS)

    In recent years, the industrial application of radiation has expanded from the cross-linking of polymers for electric wires and thermal contraction tubes to food irradiation and the sterilization of medical products and instruments. Although the dosimeters used for these radiation applications consist mostly of cellulose triacetate films, as they measure radiation dose by the change of light absorbance, they are not simple and easy to use. Sumitomo Electric Industries Ltd. has developed a simple dosimeter which utilizes the generation of hydrogen chloride occurring when polyvinyl chloride is irradiated. Radiation dose is determined by the change of color due to the change of pH using pH-indicating dyes. As the results of examining various combinations of pH-indicating dyes, it was able to develop the combination which changes color continuously with radiation dose, and which changes color at a specific radiation dose. In addition, by combining these pH-indicating dyes with a PVC stabilizer, it was able to develop the method for causing the change of dye color at a designated radiation dose. Based on these findings, 'Beam Color' radiation indicating labels and radiation color-changing ink are marketed. Thus radiation dose can be determined quickly and easily. (Kako, I.)

  16. Laser synchrotron radiation and beam cooling

    Energy Technology Data Exchange (ETDEWEB)

    Esarey, E.; Sprangle, P.; Ting, A. [Naval Research Lab., Washington, DC (United States)] [and others

    1995-12-31

    The interaction of intense {approx_gt} 10{sup 18} W/cm{sup 2}, short pulse ({approx_lt} 1 ps) lasers with electron beams and plasmas can lead to the generation of harmonic radiation by several mechanisms. Laser synchrotron radiation may provide a practical method for generating tunable, near monochromatic, well collimated, short pulse x-rays in compact, relatively inexpensive source. The mechanism for the generation of laser synchrotron radiation is nonlinear Thomson scattering. Short wavelengths can be generated via Thomson scattering by two methods, (i) backscattering from relativistic electron beams, in which the radiation frequency is upshifted by the relativistic factor 4{gamma}{sup 2}, and (ii) harmonic scattering, in which a multitude of harmonics are generated with harmonic numbers extending out to the critical harmonic number nc{approx_equal}a{sub 0}{sup 3} {much_gt} 1, where a{sub 0} {approx_equal}10{sup -9}{lambda}I{sup 1/2}, {lambda} is the laser wavelength in {mu}m and I is the laser intensity in W/cm{sup 2}. Laser synchrotron sources are capable of generating short ({approx_lt} ps) x-ray pulses with high peak flux ({approx_gt} 10{sup 21} photons/s) and brightness ({approx_gt}{sup 19} photons/s-mm{sup 2}-mrad{sup 2} 0.1%BW. As the electron beam radiates via Thomson scattering, it can subsequently be cooled, i.e., the beam emittance and energy spread can be reduced. This cooling can occur on rapid ({approximately} ps) time scales. In addition, electron distributions with sufficiently small axial energy spreads can be used to generate coherent XUV radiation via a laser-pumped FEL mechanism.

  17. Radiation damping in pulsed Gaussian beams

    CERN Document Server

    Harvey, Chris

    2011-01-01

    We consider the effects of radiation damping on the electron dynamics in a Gaussian beam model of a laser field. For high intensities, i.e. with dimensionless intensity a0 \\gg 1, it is found that the dynamics divide into three regimes. For low energy electrons (low initial {\\gamma}-factor, {\\gamma}0) the radiation damping effects are negligible. At higher energies, but still at 2{\\gamma}0 a0 one is in a regime of radiation reaction induced electron capture. This capture is found to be stable with respect to the spatial properties of the electron beam and results in a significant energy loss of the electrons. In this regime the plane wave model of the laser field provides a good description of the dynamics, whereas for lower energies the Gaussian beam and plane wave models differ significantly. Finally the dynamics are considered for the case of an XFEL field. It is found that the significantly lower intensities of such fields inhibits the damping effects.

  18. A beam radiation monitoring and protection system for AGS secondary beams

    International Nuclear Information System (INIS)

    A commercially available radiation monitor using a scintillation detector was modified for charged particle beam monitoring. The device controls access to secondary beams of the AGS and limits beam intensity

  19. Radiative transfer simulations of magnetar flare beaming

    CERN Document Server

    van Putten, T; Baring, M G; Wijers, R A M J

    2016-01-01

    Magnetar giant flares show oscillatory modulations in the tails of their light curves, which can only be explained via some form of beaming. The fireball model for magnetar bursts has been used successfully to fit the phase-averaged light curves of the tails of giant flares, but so far no attempts have been made to fit the pulsations. We present a relatively simple numerical model to simulate beaming of magnetar flare emission. In our simulations, radiation escapes from the base of a fireball trapped in a dipolar magnetic field, and is scattered through the optically thick magnetosphere of the magnetar until it escapes. Beaming is provided by the presence of a relativistic outflow, as well as by the geometry of the system. We find that a simple picture for the relativistic outflow is enough to create the pulse fraction and sharp peaks observed in pulse profiles of magnetar flares, while without a relativistic outflow the beaming is insufficient to explain giant flare rotational modulations.

  20. Helical relativistic electron beam and THz radiation

    CERN Document Server

    Son, S

    2011-01-01

    A THz laser generation utilizing a helical relativistic electron beam propagating through a strong magnetic field is discussed. The initial amplification rate in this scheme is much stronger than that in the conventional free electron laser. A magnetic field of the order of Tesla can yield a radiation in the range of 0.5 to 3 THz, corresponding to the total energy of mJ and the duration of tens of pico-second, or the temporal power of the order of GW.

  1. Summary of session 3 on synchrotron radiation and beam dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Shiltsev, V.; /Fermilab; Metral, E.; /CERN

    2010-12-01

    We summarize presentations, discussions and general conclusions of the Workshop session on 'Beam Dynamics Issues'. Major subjects include effects due to synchrotron radiation (SR), cryogenic loads, electron cloud, impedances, intra-beam scattering (IBS) and beam-beam interactions.

  2. Design and development of radiation absorber for sighting beam line

    International Nuclear Information System (INIS)

    During the commissioning of Indus-2 , it is necessary to view the synchrotron radiation that will be emanating from the dipole exit ports. The 100 beam line from dipole 11 was earmarked for sighting beam line. The synchrotron radiation power density would be around 340 watts on the photon absorber inside the radiation absorber module, at the specified beam power of Indus-2. The beam striking on this photon absorber produces x-rays and Bremsstrahlung radiation. These are to be stopped and absorbed by radiation absorber. The photon absorber and the radiation absorber are integrated in a single vacuum chamber and actuated by a pneumatic cylinder connected using a bellow. Radiation absorber was needed to isolate the diagnostic components and to protect them from radiation a well as heat when they were not in use. The paper describes the design, calculation and development of the dynamic photon cum radiation absorber. The ultimate vacuum performance is also described. (author)

  3. Coherent Radiation from Relativistic Electron Beams.

    Science.gov (United States)

    Chen, Kuan-Ren

    Two new laser concepts, the Ion-Ripple Laser (IRL) and the Ion-Channel Laser (ICL), are proposed. A unified theory for coherent radiation from relativistic electron beams devices is developed; the theory not only links the physics of Cyclotron Masers (CMs) and Free Electron Lasers (FELs) but covers the physics of the IRLs and the ICLs. We have also invented a new numerical method, the Neo-Finite -Difference (NFD) method, for electromagnetic plasma simulations and applied it to studies of these lasers. The unified amplification theory compares the growth mechanisms. Two bunching mechanisms (both axial and azimuthal) exist, not only for the noncollective single electron resonance regime, but also in the collective gain regime. Competition or reinforcement between the two bunching mechanisms is determined by the q value (a parameter that determines how the electron oscillation frequency depends on energy), the electron axial velocity, and the wave phase velocity. The unified theory concludes that, for wave amplification, the sign of the electron mismatch frequency is required to be the same as the sign of a bunching parameter that is determined by the total bunching. In an IRL, a relativistic electron beam propagates obliquely through an ion ripple in a plasma. The radiation frequency depends on the beam energy, the ripple wave number, and the angle: omega ~ 2gamma ^{2}k_{ir}ccos theta. By proper choice of device parameters, sources of microwaves, optical, and perhaps even X-rays can be made. The dispersion relation for wave coupling is derived and used to calculate the radiation frequency and linear growth rate. The nonlinear saturation mechanism is explored. Computer simulation is used to verify the ideas, scaling laws and nonlinear mechanisms. In an ICL, the ion focusing force causes the electrons to oscillate about the channel axis and plays a similar role to the magnetic field in a CM. This electron motion is nonlinear and is studied. Simulations were performed

  4. External beam radiation therapy for prostate cancer

    International Nuclear Information System (INIS)

    Purpose/Objectives: The intent of this course is to review the issues involved in the management of non-metastatic adenocarcinoma of the prostate. -- The value of pre-treatment prognostic factors including stage, grade and PSA value will be presented, and their value in determining therapeutic strategies will be discussed. -- Controversies involving the simulation process and treatment design will be presented. The value of CT scanning, Beams-Eye View, 3-D planning, intravesicle, intraurethral and rectal contrast will be presented. The significance of prostate and patient movement and strategies for dealing with them will be presented. -- The management of low stage, low to intermediate grade prostate cancer will be discussed. The dose, volume and timing of irradiation will be discussed as will the role of neo-adjuvant hormonal therapy, neutron irradiation and brachytherapy. The current status of radical prostatectomy and cryotherapy will be summarized. Treatment of locally advanced, poorly differentiated prostate cancer will be presented including a discussion of neo-adjuvant and adjuvant hormones, dose-escalation and neutron irradiation. -- Strategies for post-radiation failures will be presented including data on cryotherapy, salvage prostatectomy and hormonal therapy (immediate, delayed and/or intermittent). New areas for investigation will be reviewed. -- The management of patients post prostatectomy will be reviewed. Data on adjuvant radiation and therapeutic radiation for biochemical or clinically relapsed patients will be presented. This course hopes to present a realistic and pragmatic overview for treating patients with non-metastatic prostatic cancer

  5. The dynamics of radiation damage by focused ion beams in the ion beam synthesis

    International Nuclear Information System (INIS)

    The following topics were covered: direct ion implantation, focused ion beams, cobalt silicides (CoSi2), RBS, ion beam synthesis, CoSi2 ion beam synthesis by focused ion beams in Si(111), germanium FIB implantation in Si(111), radiation damage at FIB implantation, models and simulation. (WL)

  6. Radiation shielding of the beam absorber in the MI 8-GeV beam line

    Energy Technology Data Exchange (ETDEWEB)

    Rakhno, I.; /Fermilab

    2006-01-01

    Results of Monte Carlo radiation shielding calculations performed for the beam absorber of the MI 8 GeV beam line are presented and discussed. The possibility to reach the level of 10{sup 19} protons per year is investigated.

  7. Radiation sterilization of gelatin with electron beam

    International Nuclear Information System (INIS)

    The radiation sterilization of gelatin contaminated with 4 x 103 to 4 x 106 bacteria per gram was investigated with electron beam from a JJ-2 accelerator. After treatment with the doses of 3-4 kGy, the initial microbial counts in the gelatin could be approximately reduced by two orders of magnitude and the coliforms were substantively killed at the same time. The viscosities, transparencies and major gelatin compositions of the irradiated gelatin (with doses of 1.5-10 kGy) and the control sample were determined. The results show that the viscosity of the gelatin solution decreases gradually with the increase of the irradiation doses, the irradiation degradation of the gelatin molecules can not be decreased under the condition of nitrogen atomosphere of lower irradiation temperature, and the amino acid contents of the gelatin irradiated do not undergo any marked changes in comparison with the control sample except for cystine

  8. Transverse beam shape measurements of intense proton beams using optical transition radiation

    Energy Technology Data Exchange (ETDEWEB)

    Scarpine, Victor E.; /Fermilab

    2012-03-01

    A number of particle physics experiments are being proposed as part of the Department of Energy HEP Intensity Frontier. Many of these experiments will utilize megawatt level proton beams onto targets to form secondary beams of muons, kaons and neutrinos. These experiments require transverse size measurements of the incident proton beam onto target for each beam spill. Because of the high power levels, most beam intercepting profiling techniques will not work at full beam intensity. The possibility of utilizing optical transition radiation (OTR) for high intensity proton beam profiling is discussed. In addition, previous measurements of OTR beam profiles from the NuMI beamline are presented.

  9. EXAFS-spectroscopy on synchrotron radiation beam

    CERN Document Server

    Aksenov, V L; Kuzmin, A Y; Purans, Y

    2001-01-01

    In the review the basis theoretical principles of EXAFS spectroscopy are given, as one of principal directions of an absorption spectroscopy permitting with a high accuracy to gain parameters of the short-range order in multicomponent amorphous and quasi-crystal mediums. The methods of the analysis of EXAFS spectra with allowance of effects of multiply scattering are featured. The exposition of the experimental set-ups, which realize the method of EXAFS spectroscopy on beams of SR, requirement of the monochromatization of radiation beams are given. For investigation of phase transition and external effects the energy-dispersive EXAFS spectrometer is creating at the National center of SR Kurchatov Institute which can measure the EXAFS spectrum with a time resolution 3-5 ms. The experimental results on investigation (by the EXAFS spectroscopy method) of oxides of tungsten and molybdenum are given, which have unique property: the variable valence of an ion of metal is depending on external action. The most inter...

  10. Anomalous x-ray radiation of beam plasma

    International Nuclear Information System (INIS)

    The properties of non-equilibrium stationary plasma under the conditions of the planned plasma-chemical reactors based on beam-plasma discharge were investigated. The x-ray spectrum of the beam-plasma was measured and anomalous spectral properties were analyzed. Starting with some critical pressure the anomalous radiation was added to the classical bremsstrahlung spectrum. The occurrence of anomalous radiation can be used to diagnose the condition of beam transportation in such systems. (D.Gy.)

  11. Cellular effects after exposure to mixed beams of ionizing radiation

    OpenAIRE

    Staaf, Elina

    2012-01-01

    Mixed beams of ionizing radiation in our environment originate from space, the bedrock and our own houses. Radiotherapy patients treated with boron neutron capture therapy or with high energy photons are also exposed to mixed beams of gamma radiation and neutrons. Earlier investigations have reported additivity as well as synergism (a greater than additive response) when combining radiations of different linear energy transfer. However, the outcome seemed to be dependent on the experimental s...

  12. Two Effective Heuristics for Beam Angle Optimization in Radiation Therapy

    CERN Document Server

    Yarmand, Hamed

    2013-01-01

    In radiation therapy, mathematical methods have been used for optimizing treatment planning for delivery of sufficient dose to the cancerous cells while keeping the dose to critical surrounding structures minimal. This optimization problem can be modeled using mixed integer programming (MIP) whose solution gives the optimal beam orientation as well as optimal beam intensity. The challenge, however, is the computation time for this large scale MIP. We propose and investigate two novel heuristic approaches to reduce the computation time considerably while attaining high-quality solutions. We introduce a family of heuristic cuts based on the concept of 'adjacent beams' and a beam elimination scheme based on the contribution of each beam to deliver the dose to the tumor in the ideal plan in which all potential beams can be used simultaneously. We show the effectiveness of these heuristics for intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) on a clinical liver case.

  13. Power Beaming Leakage Radiation as a SETI Observable

    CERN Document Server

    Benford, James N

    2016-01-01

    The most observable leakage radiation from an advanced civilization may well be from the use of power beaming to transfer energy and accelerate spacecraft. Applications suggested for power beaming involve Earth-to-space applications such as launching spacecraft to orbit, raising satellites to a higher orbit, and interplanetary concepts involving space-to-space transfers of cargo or passengers. We also quantify beam-driven launch to the outer solar system, interstellar precursors and ultimately starships. We estimate the principal observable parameters of power beaming leakage. Extraterrestrial civilizations would know their power beams could be observed, and so could put a message on the power beam and broadcast it for our receipt at little additional energy or cost. By observing leakage from power beams we may find a message embedded on the beam. Recent observations of the anomalous star KIC 8462852 by the Allen Telescope Array (ATA) set some limits on extraterrestrial power beaming in that system. We show t...

  14. Radiation signatures from an external relativist electron beam

    OpenAIRE

    Wee, Kyoum Bok

    1988-01-01

    X-band radiation has been observed which occurs when an electron beam travelling in air traverses an aluminum plate. The radiation pattern is more complicated than can be explained with a simplified model of Cerenkov radiation from air and transition radiation from the aluminum-air interface. The empirical observation is that the peak angle decreases with energy until about 70 MeV, then increases with energy. The angular width of the peak distribution shows a similar behavior with energy. The...

  15. Synchrotron radiation based beam diagnostics at the Fermilab Tevatron

    CERN Document Server

    Thurman-Keup, R; Hahn, A; Hurh, P; Lorman, E; Lundberg, C; Meyer, T; Miller, D; Pordes, S; Valishev, A

    2011-01-01

    Synchrotron radiation has been used for many years as a beam diagnostic at electron accelerators. It is not normally associated with proton accelerators as the intensity of the radiation is too weak to make detection practical. However, if one utilizes the radiation originating near the edge of a bending magnet, or from a short magnet, the rapidly changing magnetic field serves to enhance the wavelengths shorter than the cutoff wavelength, which for more recent high energy proton accelerators such as Fermilab's Tevatron, tends to be visible light. This paper discusses the implementation at the Tevatron of two devices. A transverse beam profile monitor images the synchrotron radiation coming from the proton and antiproton beams separately and provides profile data for each bunch. A second monitor measures the low-level intensity of beam in the abort gaps which poses a danger to both the accelerator's superconducting magnets and the silicon detectors of the high energy physics experiments. Comparisons of measur...

  16. Open Cell Conducting Foams for High Synchrotron Radiation Beam Liners

    OpenAIRE

    Petracca, Stefania; Stabile, Arturo

    2014-01-01

    The possible use of open-cell conductive foams in high synchrotron radiation particle accelerator beam liners is considered. Available materials and modeling tools are reviewed, potential pros and cons are discussed, and preliminary conclusions are drawn.

  17. Method for separating FEL output beams from long wavelength radiation

    Energy Technology Data Exchange (ETDEWEB)

    Neil, George; Shinn, Michelle D.; Gubeli, Joseph

    2016-04-26

    A method for improving the output beam quality of a free electron laser (FEL) by reducing the amount of emission at wavelengths longer than the electron pulse length and reducing the amount of edge radiation. A mirror constructed of thermally conductive material and having an aperture therein is placed at an oblique angle with respect to the beam downstream of the bending magnet but before any sensitive use of the FEL beam. The aperture in the mirror is sized to deflect emission longer than the wavelength of the FEL output while having a minor impact on the FEL output beam. A properly sized aperture will enable the FEL radiation, which is coherent and generally at a much shorter wavelength than the bending radiations, to pass through the aperture mirror. The much higher divergence bending radiations will subsequently strike the aperture mirror and be reflected safely out of the way.

  18. Beaming of particles and synchrotron radiation in relativistic magnetic reconnection

    CERN Document Server

    Kagan, Daniel; Piran, Tsvi

    2016-01-01

    Relativistic reconnection has been invoked as a mechanism for particle acceleration in numerous astrophysical systems. According to idealised analytical models reconnection produces a bulk relativistic outflow emerging from the reconnection sites (X-points). The resulting radiation is therefore highly beamed. Using two-dimensional particle-in-cell (PIC) simulations, we investigate particle and radiation beaming, finding a very different picture. Instead of having a relativistic average bulk motion with isotropic electron velocity distribution in its rest frame, we find that the bulk motion of particles in X-points is similar to their Lorentz factor gamma, and the particles are beamed within about 5/gamma. On the way from the X-point to the magnetic islands, particles turn in the magnetic field, forming a fan confined to the current sheet. Once they reach the islands they isotropise after completing a full Larmor gyration and their radiation is not strongly beamed anymore. The radiation pattern at a given freq...

  19. Beam focusing limitation from synchrotron radiation in two dimensions

    Science.gov (United States)

    Blanco, O. R.; Tomás, R.; Bambade, P.

    2016-02-01

    The Oide effect considers the synchrotron radiation in the final focusing quadrupole, and it sets a lower limit on the vertical beam size at the interaction point, particularly relevant for high-energy linear colliders. The theory of the Oide effect was derived considering only the second moment of the radiation in the focusing plane of the magnet. This article addresses the theoretical calculation of the radiation effect on the beam size considering the first and second moments of the radiation and both focusing and defocusing planes of the quadrupole. The effect for a Gaussian beam is referred to as 2D-Oide; however, an alternative beam size figure is given that could represent better the effect on the minimum achievable βy* . The CLIC 3 TeV final quadrupole (QD0) and beam parameters are used to compare the theoretical results from the Oide effect and the 2D-Oide effect with particle tracking in placet. The 2D-Oide effect is demonstrated to be important, as it increases by 17% the contribution to the beam size. Further insight into the aberrations induced by the synchrotron radiation opens the possibility to partially correct the 2D-Oide effect with octupole magnets. A beam size reduction of 4% is achieved in the simplest configuration, using a single octupole.

  20. Anesthesia for pediatric external beam radiation therapy

    International Nuclear Information System (INIS)

    Background: For very young patients, anesthesia is often required for radiotherapy. This results in multiple exposures to anesthetic agents over a short period of time. We report a consecutive series of children anesthetized for external beam radiation therapy (EBRT). Methods: Five hundred twelve children ≤ 16 years old received EBRT from January 1983 to February 1996. Patient demographics, diagnosis, anesthesia techniques, monitoring, airway management, complications, and outcome were recorded for the patients requiring anesthesia. Results: One hundred twenty-three of the 512 children (24%) required 141 courses of EBRT with anesthesia. Anesthetized patients ranged in age from 20 days to 11 years (mean 2.6 ± 1.8 ). The frequency of a child receiving EBRT and requiring anesthesia by age cohort was: ≤ 1 year (96%), 1-2 years (93%), 2-3 years (80%), 3-4 years (51%), 4-5 years (36%), 5-6 years (13%), 6-7 years (11%), and 7-16 years (0.7%). Diagnoses included: primary CNS tumor (28%), retinoblastoma (27%), neuroblastoma (20%), acute leukemia (9%), rhabdomyosarcoma (6%), and Wilms' tumor (4%). Sixty-three percent of the patients had been exposed to chemotherapy prior to EBRT. The mean number of anesthesia sessions per patient was 22 ± 16. Seventy-eight percent of the treatment courses were once daily and 22% were twice daily. Anesthesia techniques included: short-acting barbiturate induction + inhalation maintenance (21%), inhalation only (20%), ketamine (19%), propofol only (12%), propofol induction + inhalation maintenance (7%), ketamine induction + inhalation maintenance (6%), ketamine or short-acting barbiturate induction + inhalation maintenance (6%). Monitoring techniques included: EKG (95%), O2 saturation (93%), fraction of inspired O2 (57%), and end-tidal CO2 (55%). Sixty-four percent of patients had central venous access. Eleven of the 74 children with a central line developed sepsis (15%): 6 of the 11 were anesthetized with propofol (55%), 4 with a short

  1. Beaming of Particles and Synchrotron Radiation in Relativistic Magnetic Reconnection

    Science.gov (United States)

    Kagan, Daniel; Nakar, Ehud; Piran, Tsvi

    2016-08-01

    Relativistic reconnection has been invoked as a mechanism for particle acceleration in numerous astrophysical systems. According to idealized analytical models, reconnection produces a bulk relativistic outflow emerging from the reconnection sites (X-points). The resulting radiation is therefore highly beamed. Using two-dimensional particle-in-cell simulations, we investigate particle and radiation beaming, finding a very different picture. Instead of having a relativistic average bulk motion with an isotropic electron velocity distribution in its rest frame, we find that the bulk motion of the particles in X-points is similar to their Lorentz factor γ, and the particles are beamed within ˜ 5/γ . On the way from the X-point to the magnetic islands, particles turn in the magnetic field, forming a fan confined to the current sheet. Once they reach the islands they isotropize after completing a full Larmor gyration and their radiation is no longer strongly beamed. The radiation pattern at a given frequency depends on where the corresponding emitting electrons radiate their energy. Lower-energy particles that cool slowly spend most of their time in the islands and their radiation is not highly beamed. Only particles that quickly cool at the edge of the X-points generate a highly beamed fan-like radiation pattern. The radiation emerging from these fast cooling particles is above the burn-off limit (˜100 MeV in the overall rest frame of the reconnecting plasma). This has significant implications for models of gamma-ray bursts and active galactic nuclei that invoke beaming in that frame at much lower energies.

  2. Apparatus for defining a beam of ionizing radiation

    International Nuclear Information System (INIS)

    Novel apparatus for defining a beam of ionizing radiation in the course of radiotherapy treatment is described in detail. The particular case of electron irradiation of the patient is discussed. The apparatus consists of an adjustable primary collimator which produces a cone of ionizing radiation, an attachment holder adjacent to the primary collimator and a detachable radiation applicator. The attachment holder may be removed when irradiation with X-rays is desired. (U.K.)

  3. Device for limiting a beam of high-energy radiation

    International Nuclear Information System (INIS)

    In order to account for the varying scattered radiation and to optimize the image quality of the radiograph to be produced by the X-radiation, the radiation exit opening can be altered by means of trapezoidal shutter elements. For this purpose the shutter elements are designed swinging and, at their edges, gear tooth-like, thus forming a pyramidal shutter mechanism whose inclinitation with respect to the beam axis is adjustable (collimator). (RW)

  4. Beam diagnostics using transition radiation produced by a 100 Mev electron beam

    International Nuclear Information System (INIS)

    We report on several experiments using the optical transition radiation (OTR) produced by a 100 MeV electron beam. In using a sensitive video camera coupled with a digital image processing system an accurate and simple beam profile monitor has been devised. In measuring with a photo-multiplier the radiation emitted in a small solid angle around the direction of the OTR emission, a signal very sensitive to beam energy variations has been obtained. These experiments have been carried out on the Saclay ALS linac

  5. Study on external beam radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Mi Sook; Yoo, Seoung Yul; Yoo, Hyung Jun; Ji, Young Hoon; Lee, Dong Han; Lee, Dong Hoon; Choi, Mun Sik; Yoo, Dae Heon; Lee, Hyo Nam; Kim, Kyeoung Jung

    1999-04-01

    To develop the therapy technique which promote accuracy and convenience in external radiation therapy, to obtain the development of clinical treatment methods for the global competition. The contents of the R and D were 1. structure, process and outcome analysis in radiation therapy department. 2. Development of multimodality treatment in radiation therapy 3. Development of computation using networking techniques 4. Development of quality assurance (QA) system in radiation therapy 5. Development of radiotherapy tools 6. Development of intraoperative radiation therapy (IORT) tools. The results of the R and D were 1. completion of survey and analysis about Korea radiation therapy status 2. Performing QA analysis about ICR on cervix cancer 3. Trial of multicenter randomized study on lung cancers 4. Setting up inter-departmental LAN using MS NT server and Notes program 5. Development of ionization chamber and dose-rate meter for QA in linear accelerator 6. Development on optimized radiation distribution algorithm for multiple slice 7. Implementation on 3 dimensional volume surface algorithm and 8. Implementation on adaptor and cone for IORT.

  6. Study on external beam radiation therapy

    International Nuclear Information System (INIS)

    To develop the therapy technique which promote accuracy and convenience in external radiation therapy, to obtain the development of clinical treatment methods for the global competition. The contents of the R and D were 1. structure, process and outcome analysis in radiation therapy department. 2. Development of multimodality treatment in radiation therapy 3. Development of computation using networking techniques 4. Development of quality assurance (QA) system in radiation therapy 5. Development of radiotherapy tools 6. Development of intraoperative radiation therapy (IORT) tools. The results of the R and D were 1. completion of survey and analysis about Korea radiation therapy status 2. Performing QA analysis about ICR on cervix cancer 3. Trial of multicenter randomized study on lung cancers 4. Setting up inter-departmental LAN using MS NT server and Notes program 5. Development of ionization chamber and dose-rate meter for QA in linear accelerator 6. Development on optimized radiation distribution algorithm for multiple slice 7. Implementation on 3 dimensional volume surface algorithm and 8. Implementation on adaptor and cone for IORT

  7. Collisionless Beam-radiation Processes In The Laboratory And Astrophysics

    CERN Document Server

    Schmekel, B S

    2005-01-01

    Plasma instabilities can be encountered in many branches of physics. This work focuses on relativistic plasmas with applications in theoretical astrophysics and particle accelerator physics. Even though these fields seem to be unrelated the underlying plasma physics processes are often very similar. Two plasma instabilities - the beam-beam instability and the coherent synchrotron radiation instability - are analyzed. The former severely limits the achievable luminosity in storage rings and is related to the two- stream instability which has been proposed as a candidate for the radiation mechanism of radio pulsars. The main emphasis is on coherent synchrotron radiation which can lead to prohibitive energy losses in bunch compressors. Coherent synchrotron radiation also makes up the intense emission of radio waves by pulsars. Simple models based on the linearized Vlasov equation and relativistic magnetohydrodynamics which allow to compute detailed spectra of the emitted radiation are developed.

  8. Collisionless Beam-Radiation Processes in the Laboratory and Astrophysics

    CERN Document Server

    Schmekel, Bjoern S

    2009-01-01

    Plasma instabilities can be encountered in many branches of physics. This work focuses on relativistic plasmas with applications in theoretical astrophysics and particle accelerator physics. Even though these fields seem to be unrelated the underlying plasma physics processes are often very similar. Two plasma instabilities - the beam-beam instability and the coherent synchrotron radiation instability - are analyzed. The former severely limits the achievable luminosity in storage rings and is related to the two-stream instability which has been proposed as a candidate for the radiation mechanism of radio pulsars. The main emphasis is on coherent synchrotron radiation which can lead to prohibitive energy losses in bunch compressors. Coherent synchrotron radiation also makes up the intense emission of radio waves by pulsars. Simple models based on the linearized Vlasov equation and relativistic magnetohydrodynamics which allow to compute detailed spectra of the emitted radiation are developed.

  9. Power Beaming Leakage Radiation as a SETI Observable

    Science.gov (United States)

    Benford, James N.; Benford, Dominic J.

    2016-07-01

    The most observable leakage radiation from an advanced civilization may well be from the use of power beaming to transfer energy and accelerate spacecraft. Applications suggested for power beaming involve launching spacecraft to orbit, raising satellites to a higher orbit, and interplanetary concepts involving space-to-space transfers of cargo or passengers. We also quantify beam-driven launch to the outer solar system, interstellar precursors, and ultimately starships. We estimate the principal observable parameters of power beaming leakage. Extraterrestrial civilizations would know their power beams could be observed, and so could put a message on the power beam and broadcast it for our receipt at little additional energy or cost. By observing leakage from power beams we may find a message embedded on the beam. Recent observations of the anomalous star KIC 8462852 by the Allen Telescope Array (ATA) set some limits on extraterrestrial power beaming in that system. We show that most power beaming applications commensurate with those suggested for our solar system would be detectable if using the frequency range monitored by the ATA, and so the lack of detection is a meaningful, if modest, constraint on extraterrestrial power beaming in that system. Until more extensive observations are made, the limited observation time and frequency coverage are not sufficiently broad in frequency and duration to produce firm conclusions. Such beams would be visible over large interstellar distances. This implies a new approach to the SETI search: instead of focusing on narrowband beacon transmissions generated by another civilization, look for more powerful beams with much wider bandwidth. This requires a new approach for their discovery by telescopes on Earth. Further studies of power beaming applications should be performed, potentially broadening the parameter space of the observable features that we have discussed here.

  10. Synchrotron radiation damping, intrabeam scattering and beam-beam simulations for HE-LHC

    CERN Document Server

    Valishev, A

    2011-01-01

    The proposed High-Energy LHC project presents an unusual combination of strong synchrotron radiation (SR) damping and intrabeam scattering (IBS), which is not seen in present-day hadron colliders. The subject of investigation reported in this paper was the simulation of beam-beam effect for the HE-LHC parameters. Parameters of SR and IBS are calculated, and the luminosity evolution is simulated in the absence of beambeam interaction. Then, a weak-strong numerical simulation is used to predict the effect of beam-beam interaction on particle losses and emittance evolution.

  11. Coherent X-ray Cherenkov radiation produced by microbunched beams

    International Nuclear Information System (INIS)

    Analytical and numerical results on the coherent X-ray Cherenkov radiation (CXCR) produced by microbunched beams in the region near the K-, L-edges of materials are obtained. The results show that CXCR can serve as a suitable mechanism for production intense beams of photons in the 'water window' region as well as for studying the important microbunching process at FLASH TESLA, LCLS and other FELs.

  12. Responses of diode detectors to radiation beams from teletherapy machines

    International Nuclear Information System (INIS)

    Responses of diode detectors to radiation beams from teletherapy machines. It has been carried out responses to two sets of diode detector by using the beams of teletherapy Co-60 and medical linear accelerator. Each set of consist of 8 diode detectors was irradiated by using gamma beams from teletherapy Co-60 machines and 6 MV and 10 MV foron beams from medical linear accelerator and 6.9.12.16. and 20 MeV electron beams from medical linear accelerator. The detectors were positioned on the phantom circularly and radially and electronic equilibrium condition for all type and energy beams. It was found that every detectors had own individual response and it is not to be uniformity, since the fluctuation in between 16.6 % to 30.9 %. All detectors responses are linear to gamma and foron beams, and also for energy above 6 MeV for electron beams. Nonlinearity response occurs for 6 MeV electron beam, it is probably from the assumption of electronic equilibrium

  13. Radiation degradation of marine polysaccharides by low energy electron beam

    International Nuclear Information System (INIS)

    The radiation degradations of marine polysaccharides by both gamma Co-60 and electron beam irradiations are investigated. Polysaccharides and oligosaccharides can be produced by degradation of corresponding polysaccharides including marine polysaccharides such as alginates, chitin chitosan and carrageenan. The viscosity of alginate, chitosan and carrageenan solution decreases markedly with increase of the low energy electron beam irradiation time and the beam current. Furthermore, the viscosity is reduced sharply in short time for polysaccharide solution with low concentration, for instance carrageenan solution of 1%. (author)

  14. Spectral properties of Compton inverse radiation: Application of Compton beams

    CERN Document Server

    Bulyak, Eugene

    2013-01-01

    Compton inverse radiation emitted due to backscattering of laser pulses off the relativistic electrons possesses high spectral density and high energy of photons - in hard x-ray up to gamma-ray energies - because of short wavelength of laser radiation as compared with the classical electromagnetic devices such as undulators. In this report, the possibility of such radiation to monochromatization by means of collimation is studied. Two approaches have been considered for the description of the spectral-angular density of Compton radiation based on the classical field theory and on the quantum electrodynamics. As is shown, both descriptions produce similar total spectra. On the contrary, angular distribution of the radiation is different: the classical approach predicted a more narrow radiation cone. Also proposed and estimated is a method of the `electronic' monochromatization based on the electronic subtraction of the two images produced by the electron beams with slightly different energies. A `proof-of-prin...

  15. Radiation sterilization by 10 MeV electron beams

    International Nuclear Information System (INIS)

    Gamma-ray sterilization by 60Co source has been already popular in Japan. Many Kinds of medical plastic devices such as catheters, disposable syringes, dializers etc, has been irradiated at 60Co irradiation facilities instead of the conventional ethylene oxide fumigation method. On the other hand, improvement of the quality of electron accelerators has made it easier to take advantage of relatively high energy electrons which are profitable for radiation sterilization because of their high dose rate saving process hours and easiness of source handling and radiation control. So electron-beam sterilization is now under investigation in Japan and, partly, it will be practiced in the near future. Yet few data are available in the present situation. Especially for high energy electron beams near 10 MeV, more data are necessary for practical application of electron-beam sterilization. Therefore, in this study, sensitivity of Bacillus pumilus E601, the biological standard of radiation sterilization, was examined using 10 MeV electron beams from linear accelerator and sterility of the beams was also checked at each depth of plastic boards in order to get basic information for determination of sterility dose. Endospores from B. pumilus were dried on filter papers (Toyo No.1) and irradiated by 10 MeV electron beams of 60Co gamma-rays. The survival curves were shown in Fig. 1. The D values were obtained as 1.9 kGy ± 0.2 for electron beams and 1.7 kGy ± 0.1 for 60Co gamma-rays, both of which were similar. Electron beams could sterilize the endospores nearly uniformly till 3 cm depth of plastic boards at 10 MeV (Fig. 2,3). This indicates a possibility to sterilize relatively bulky products such as dializers etc. (author)

  16. Online external beam radiation treatment simulator

    International Nuclear Information System (INIS)

    Radiation therapy is an effective and widely accepted form of treatment for many types of cancer that requires extensive computerized planning. Unfortunately, current treatment planning systems have limited or no visual aid that combines patient volumetric models extracted from patient-specific CT data with the treatment device geometry in a 3D interactive simulation. We illustrate the potential of 3D simulation in radiation therapy with a web-based interactive system that combines novel standards and technologies. We discuss related research efforts in this area and present in detail several components of the simulator. An objective assessment of the accuracy of the simulator and a usability study prove the potential of such a system for simulation and training. (orig.)

  17. Calculating the background radiation in the vicinity of the beam catchers of the ELBE radiation source

    International Nuclear Information System (INIS)

    The ELBE radiation sources comprises beam catchers in the experimenting sites which absorb the primary electron beam as well as the generated secondary radiation. The beam catcher consists of an ultrapure graphite absorber enclosed in a water-cooled stainless steel shell. Background radiation is shielded by iron, lead and heavy concrete. The beam parameters and the position of the beam catchers differ between experimenting sites. In order to determine the dose dependence of photon and neutron fluence and the dose equivalent at the cooling shell of the beam catcher, simulations were carried out using the FLUKA code. Radiation energies of 20 MeV and 50 MeV and electron fluxes of 1 mA were considered. The spatial and energetic distributions of the dose rate equivalent provide a basis for dimensioning of the radiation shields. The calculated distributions of the energy dose rate in the beam catcher serve as a basis for assessing thermal loads on materials and for designing the cooling system. (orig.)

  18. Electron Beam Instrumentation Techniques Using Coherent Radiation

    Science.gov (United States)

    Wang, D. X.

    1997-05-01

    In recent years, there has been increasing interest in short electron bunches for different applications such as short wavelength FELs, linear colliders, advanced accelerators such as laser or plasma wakefield accelerators, and Compton backscattering X-ray sources. A short bunch length is needed to meet various requirements such as high peak current, low momentum spread, high luminosity, small ratio of bunch length to plasma wavelength, or accurate timing. Meanwhile, much progress has been made on photoinjectors and different magnetic and RF bunching schemes to produce very short bunches. Measurement of those short bunches becomes essential to develop, characterize, and operate such demanding machines. Conventionally, bunch duration of short electron bunches is measured by transverse RF deflecting cavities or streak camera. With such devices it becomes very challenging to measure bunch length down to a few hundred femtoseconds. Many frequency domain techniques have been recently developed, based on a relation between bunch profile and coherent radiation spectrum. These techniques provide excellent performance for short bunches. In this paper, coherent radiation and its applications to bunch length measurement will be discussed. A strategy for bunch length control at Jefferson Lab will be presented, which includes a noninvasive coherent synchrotron radiation (CSR) monitor, a zero-phasing technique used to calibrate the CSR detector, and phase transfer measurement used to correct RF phase drifts.

  19. Electron beam radiation of resin luting agents - a cytotoxic evaluation

    International Nuclear Information System (INIS)

    The aim of this study was to evaluate and compare the cytotoxicity of three resin luting agents rely x luting cement, rely x luting 2 cement, and clearfil SA luting agent on human dental pulp cells before and after electron beam irradiation. Growth and maintenance of cell cultures of human pulp cells was done in Dulbecco's modified Eagle's Medium (DMEM). The test samples were divided into two categories based on radiation exposure, irradiated category and non-radiated category. Samples in Irradiated category were exposed to electron beam radiation after dose standardisation (Microtron, Electron Beam Accelerator, Microtron Centre, Mangalore University). The dose of radiation used was 200 Gy. Two subgroups of radiated category were made. In 1st sub-group (containing 18 samples), all the 3 luting cements will be placed in sterile packets and irradiated without mixing the two components. In 2nd sub-group (containing 18 samples), all the 3 luting cements will be mixed separately, placed in sterile packets and exposed to electron-beam radiations. Samples in non radiated category were also made 2 groups. In 1st sub-group (containing 18 samples), all the 3 luting cements will be placed in sterile teflon moulds and kept in a humid chamber at 37℃ without mixing the two components. In 2nd sub-group (containing 18 samples), all the 3 the luting cements will be mixed separately, placed in sterile teflon moulds and kept in a humid chamber at 37℃. All the samples were subjected to MTT assay and spectrophotometric analysis and their cytotoxicity was assessed. (author)

  20. Short Electron Beam Bunch Characterization Through Measurement of Terahertz Radiation

    CERN Document Server

    Zhang, Shukui; Douglas, David; Shinn, Michelle D; Williams, Gwyn

    2004-01-01

    Characterization of the electron beam bunch length of the upgrade FEL at Jefferson Lab was performed by analyzing the FTIR spectra of the coherent terahertz pulses. The results are compared with autocorrelation from a scanning polarization autocorrelator that measures the optical transition radiation. The limitations of the different methods to such a characterization are presented in this paper.

  1. Prospects for radiation-beam treatment of materials for atomics

    International Nuclear Information System (INIS)

    A consideration is given to various types of radiation-beam technology (ion, plasma, ion-plasma treatments, irradiation with concentrated fluxes of energy) as well as to prospects of their use for optimization of structural and phase states of reactor materials and for surface finishing. The results of corrosion tests and structural studies are presented for fuel tubes of Eh110 and Eh635 zirconium alloys and steels ChS-68, EhJ847, EhP172, EhP450, EhP753 before and after radiation-beam treatments. It is revealed that corrosion resistance and wear resistance are enhanced due to structural changes in a subsurface layer. The advantages of radiation-beam technology are noted to be ecological safety, low power consumption, high controllability and predictability of the results of action, a possibility to vary essentially the element composition and the phase state of a surface layer, as well as to form a specified surface relief. The radiation-beam technology is shown to be promising for treatment of nuclear reactor core components operating under severe conditions

  2. A phase-space beam position monitor for synchrotron radiation

    Energy Technology Data Exchange (ETDEWEB)

    Samadi, Nazanin, E-mail: nazanin.samadi@usask.ca [University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK (Canada); Bassey, Bassey; Martinson, Mercedes [University of Saskatchewan, 116 Science Place, Saskatoon, SK (Canada); Belev, George; Dallin, Les; Jong, Mark de [Canadian Light Source, 44 Innovation Boulevard, Saskatoon, SK (Canada); Chapman, Dean [University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK (Canada)

    2015-06-25

    A system has been developed to measure the vertical position and angle of the electron beam at a single location from a synchrotron source. The system uses a monochromator tuned to the absorption edge of a contrast material and has a sensitivity comparable with other beam position monitors. The stability of the photon beam position on synchrotron beamlines is critical for most if not all synchrotron radiation experiments. The position of the beam at the experiment or optical element location is set by the position and angle of the electron beam source as it traverses the magnetic field of the bend-magnet or insertion device. Thus an ideal photon beam monitor would be able to simultaneously measure the photon beam’s position and angle, and thus infer the electron beam’s position in phase space. X-ray diffraction is commonly used to prepare monochromatic beams on X-ray beamlines usually in the form of a double-crystal monochromator. Diffraction couples the photon wavelength or energy to the incident angle on the lattice planes within the crystal. The beam from such a monochromator will contain a spread of energies due to the vertical divergence of the photon beam from the source. This range of energies can easily cover the absorption edge of a filter element such as iodine at 33.17 keV. A vertical profile measurement of the photon beam footprint with and without the filter can be used to determine the vertical centroid position and angle of the photon beam. In the measurements described here an imaging detector is used to measure these vertical profiles with an iodine filter that horizontally covers part of the monochromatic beam. The goal was to investigate the use of a combined monochromator, filter and detector as a phase-space beam position monitor. The system was tested for sensitivity to position and angle under a number of synchrotron operating conditions, such as normal operations and special operating modes where the photon beam is intentionally altered

  3. Patient radiation doses for electron beam CT

    International Nuclear Information System (INIS)

    A Monte Carlo based computer model has been developed for electron beam computed tomography (EBCT) to calculate organ and effective doses in a humanoid hermaphrodite phantom. The program has been validated by comparison with experimental measurements of the CT dose index in standard head and body CT dose phantoms; agreement to better than 8% has been found. The robustness of the model has been established by varying the input parameters. The amount of energy deposited at the 12:00 position of the standard body CT dose phantom is most susceptible to rotation angle, whereas that in the central region is strongly influenced by the beam quality. The program has been used to investigate the changes in organ absorbed doses arising from partial and full rotation about supine and prone subjects. Superficial organs experience the largest changes in absorbed dose with a change in subject orientation and for partial rotation. Effective doses for typical clinical scan protocols have been calculated and compared with values obtained using existing dosimetry techniques based on full rotation. Calculations which make use of Monte Carlo conversion factors for the scanner that best matches the EBCT dosimetric characteristics consistently overestimate the effective dose in supine subjects by typically 20%, and underestimate the effective dose in prone subjects by typically 13%. These factors can therefore be used to correct values obtained in this way. Empirical dosimetric techniques based on the dose-length product yield errors as great as 77%. This is due to the sensitivity of the dose length product to individual scan lengths. The magnitude of these errors is reduced if empirical dosimetric techniques based on the average absorbed dose in the irradiated volume (CTDIvol) are used. Therefore conversion factors specific to EBCT have been calculated to convert the CTDIvol to an effective dose

  4. A study of radiation-hard detectors using proton beam

    International Nuclear Information System (INIS)

    We studied radiation damage effect of inorganic and organic scintillators developed in Korea by proton beam irradiation using the MC-50 Cyclotron facility in Atomic Cancer Hospital. After developing radiation hard detectors, it can be used for the proton beam flux and energy monitoring in a real time. We also perform a research on electronics and DAQ for such a device. The following is our major study : a development of liquid scintillator, a development of plastic scintillator, a study on liquid scintillator response, simulation study of liquid scintillator by proton beam interaction, detector irradiation at MC-50 Cyclotron facility and a study of response change, a development of electronics for proton flux monitoring and a feasibility study of low proton flux monitoring, initial study of inorganic scintillator by the proton beamtest

  5. Measurement of microwave radiation from electron beam in the atmosphere

    Science.gov (United States)

    Ohta, I. S.; Akimune, H.; Fukushima, M.; Ikeda, D.; Inome, Y.; Matthews, J. N.; Ogio, S.; Sagawa, H.; Sako, T.; Shibata, T.; Yamamoto, T.

    2016-02-01

    We report the use of an electron light source (ELS) located at the Telescope Array Observatory in Utah, USA, to measure the isotropic microwave radiation from air showers. To simulate extensive air showers, the ELS emits an electron beam into the atmosphere and a parabola antenna system for the satellite communication is used to measure the microwave radiation from the electron beam. Based on this measurement, an upper limit on the intensity of a 12.5 GHz microwave radiation at 0.5 m from a 1018 eV air shower was estimated to be 3.96×10-16 W m-2 Hz-1 with a 95% confidence level.

  6. External Beam Radiation in Differentiated Thyroid Carcinoma

    Directory of Open Access Journals (Sweden)

    Salem Billan

    2016-01-01

    Full Text Available The treatment of differentiated thyroid carcinoma (DTC is surgery followed in some cases by adjuvant treatment, mostly with radioactive iodine (RAI. External beam radiotherapy (EBRT is less common and not a well-established treatment modality in DTC. The risk of recurrence depends on three major prognostic factors: extra-thyroid extension, patient’s age, and tumor with reduced iodine uptake. Increased risk for recurrence is a major factor in the decision whether to treat the patient with EBRT. Data about the use of EBRT in DTC are limited to small retrospective studies. Most series have demonstrated an increase in loco-regional control. The risk/benefit from giving EBRT requires careful patient selection. Different scoring systems have been proposed by different investigators and centers. The authors encourage clinicians treating DTC to become familiarized with those scoring systems and to use them in the management of different cases. The irradiated volume should include areas of risk for microscopic disease. Determining those areas in each case can be difficult and requires detailed knowledge of the surgery and pathological results, and also understanding of the disease-spreading pattern. Treatment with EBRT in DTC can be beneficial, and data support the use of EBRT in high-risk patients. Randomized controlled trials are needed for better confirmation of the role of EBRT.

  7. Beam loss and radiation effects in the SSC lattice elements

    International Nuclear Information System (INIS)

    The Superconducting Super Collider (SSC) is designed to be an advanced machine with relatively low beam loss-induced radiation levels. However, a fraction of the beam lost in the lattice due to pp-collisions at the interaction points, beam-gas scattering, bearn-halo scraping, various instabilities and errors will result in the irradiation of conventional and superconducting components of the accelerator and experimental apparatus. The level of the beam loss and its distribution along the machine structure has impact on all of the three crucial radiation effects at the SSC: quenching of the superconducting magnets, survivability of the accelerator and detectors components in the near-beam regions, and influence to the environment. This paper, based on the full-scale Monte Carlo simulation, will explore all major sources of beam loss in the Collider and measures to reduce the irradiation of the accelerator components. Basic parameters of the Super Collider accepted throughout this report are as follows: Proton energy E0 = 20 TeV, injection energy is 2 TeV, number of protons circulating in each of the collider rings is N = 1.3 x 1014, circumference is 87.12 km, the transverse normalized emittance var-epsilon N(σ) = 1 π mm-mrad, for the regular lattice (β = 305 m) the beam R.M.S. sizes are σ = 0.12 mm at 20 TEV and σ = 0.38 mm at the injection energy. The dipole length is 15.815 m with the effective field length of 15.165 m. The magnetic field map for B0 = 6.5999 T has been calculated with the POISSON program by Greg Snitchler. The turn angle of each dipole is α = 1.50027 mrad. The dipole aperture is 50 mm. The two beam pipe diameters are studied 33 and 40 mm. The operating temperature is T0 = 4.35 K

  8. Radiation Tolerance of Cryogenic Beam Loss Monitor Detectors

    CERN Document Server

    Kurfuerst, C; Bartosik, M; Dehning, B; Eisel, T; Sapinski, M; Eremin, V; Verbitskaya, E; Fabjan, C; Griesmayer, E

    2013-01-01

    At the triplet magnets, close to the interaction regions of the LHC, the current Beam Loss Monitoring system is sensitive to the particle showers resulting from the collision of the two beams. For the future, with beams of higher energy and intensity resulting in higher luminosity, distinguishing between these interaction products and possible quench-provoking beam losses from the primary proton beams will be challenging. Investigations are therefore underway to optimise the system by locating the beam loss detectors as close as possible to the superconducting coils of the triplet magnets. This means putting detectors inside the cold mass in superfluid helium at 1.9 K. Previous tests have shown that solid state diamond and silicon detectors as well as liquid helium ionisation chambers are promising candidates. This paper will address the final open question of their radiation resistance for 20 years of nominal LHC operation, by reporting on the results from high irradiation beam tests carried out at CERN in a...

  9. Study of radiation detectors response in standard X, gamma and beta radiation standard beams

    International Nuclear Information System (INIS)

    The response of 76 Geiger-Mueller detectors, 4 semiconductor detectors and 34 ionization chambers were studied. Many of them were calibrated with gamma radiation beams (37Cs and 60Co), and some of them were tested in beta radiation (90Sr+9'0Y e 204Tl) and X radiation (N-60, N-80, N-100, N-150) beams. For all three types of radiation, the calibration factors of the instruments were obtained, and the energy and angular dependences were studied. For beta and gamma radiation, the angular dependence was studied for incident radiation angles of 0 deg and +- 45 deg. The curves of the response of the instruments were obtained over an angle interval of 0 deg to +- 90 deg, for gamma, beta and X radiations. The calibration factors obtained for beta radiation were compared to those obtained for gamma radiation. For gamma radiation, 24 of the 66 tested Geiger-Mueller detectors presented results for the energy dependence according to international recommendation of ISO 4037-2 and 56 were in accordance with the Brazilian ABNT 10011 recommendation. The ionization chambers and semiconductors were in accordance to national and international recommendations. All instruments showed angular dependence less than 40%. For beta radiation, the instruments showed unsatisfactory results for the energy dependence and angular dependence. For X radiation, the ionization chambers presented results for energy dependence according to the national recommendation, and the angular dependence was less than 40%. (author)

  10. Radiation effects of electron-beam metal depositions on IGFET's

    International Nuclear Information System (INIS)

    Electron-beam radiation effects on n-channel IGFET parameters were studied. This paper summarizes the resulting surface- and dielectric-radiation effects obtained with a series of experiments incorporating e-gun metal deposition on MOS, MNOS, and SNOS structures. The results are compared with those using resistance-heated metal deposition for various thin-film compositions between the metal and silicon surfaces. A comparison is also made with the effects of controlled direct e-beam irradiation of the structures. The efficiency of quartz and aluminum thin films over MNOS structures, in reducing e-gun radiation effects, is evaluated for double-level metallurgy structures. The effect of different thermal-annealing conditions for offsetting the radiation effects is determined. It is concluded that e-gun metallization causes large negative voltage shifts in MOS, MNOS, and SNOS devices. While MOS threshold shifts are fully ''annealable'', residual MNOS and SNOS V/sub T/ shifts are observed after an anneal of 3500/4500C. Thin films of quartz and aluminum over MOS and MNOS structures effectively reduce radiation effects. Other IGFET parameters are not substantially affected by e-gun radiation

  11. Thin silicon strip detectors for beam monitoring in Micro-beam Radiation Therapy

    CERN Document Server

    Povoli, Marco; Bravin, Alberto; Cornelius, Iwan; Bräuer-Krisch, Elke; Fournier, Pauline; Hansen, Thor-Erik; Kok, Angela; Lerch, Michael; Monakhov, Edouard; Morse, John; Petasecca, Marco; Requardt, Herwig; Rosenfeld, Anatoly; Röhrich, Dieter; Sandaker, Heidi; Salomé, Murielle; Stugu, Bjarne

    2015-01-01

    Microbeam Radiation Therapy (MRT) is an emerging cancer treatment that is currently being developed at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France. This technique uses a highly collimated and fractionated X-ray beam array with extremely high dose rate and very small divergence, to benefit from the dose-volume effect, thus sparing healthy tissue. In case of any beam anomalies and system malfunctions, special safety measures must be installed, such as an emergency safety shutter that requires continuous monitoring of the beam intensity profile. Within the 3DMiMic project, a novel silicon strip detector that can tackle the special features of MRT, such as the extremely high spatial resolution and dose rate, has been developed to be part of the safety shutter system. The first prototypes have been successfully fabricated, and experiments aimed to demonstrate their suitability for this unique application have been performed. Design, fabrication and the experimental results as well as any...

  12. The potential of proton beam radiation therapy in breast cancer

    International Nuclear Information System (INIS)

    A group of Swedish oncologists and hospital physicists have estimated the number of patients in Sweden suitable for proton beam therapy. The estimations have been based on current statistics of tumour incidence, number of patients potentially eligible for radiation treatment, scientific support from clinical trials and model dose planning studies and knowledge of the dose-response relations of different tumours and normal tissues. In primary breast cancer, it is estimated that about 300 of the annually 3,425 irradiated patients can potentially be candidates for proton beam therapy to reduce late toxicity, mainly from the heart and lungs

  13. Terahertz plasmonic laser radiating in an ultra-narrow beam

    CERN Document Server

    Wu, Chongzhao; Reno, John L; Kumar, Sushil

    2016-01-01

    Plasmonic lasers (spasers) generate coherent surface-plasmon-polaritons (SPPs) and could be realized at subwavelength dimensions in metallic cavities for applications in nanoscale optics. Plasmonic cavities are also utilized for terahertz quantum-cascade lasers (QCLs), which are the brightest available solid-state sources of terahertz radiation. A long standing challenge for spasers is their poor coupling to the far-field radiation. Unlike conventional lasers that could produce directional beams, spasers have highly divergent radiation patterns due to their subwavelength apertures. Here, we theoretically and experimentally demonstrate a new technique for implementing distributed-feedback (DFB) that is distinct from any other previously utilized DFB schemes for semiconductor lasers. The so-termed antenna-feedback scheme leads to single-mode operation in plasmonic lasers, couples the resonant SPP mode to a highly directional far-field radiation pattern, and integrates hybrid SPPs in surrounding medium into the ...

  14. Study on radiation sterilization of electron beam accelerator

    International Nuclear Information System (INIS)

    To study the effects of radiation sterilization of the electron beam, the three species of microorganisms, Escherichia. coli, Staphylococcus aureus and Proteus vulgaris were irradiated with the electron beam, delivered by the electron accelerator independently developed by the Institute of Modern Physics, Chinese Academy of Sciences, and the changes of superoxide dismutase (SOD) activity of these irradiated microorganisms were also tested. The results indicated that the Staphylococcus aureus were fully radio-sterilized with the radiation dosage of 2.0 kGy, but 2.2 kGy to the Escherichia. coli and Proteus vulgaris. Moreover, the data also demonstrated that the irradiation had noticeable effects on the SOD activity of the three microorganisms. (authors)

  15. Development of resistant materials to beam impact and radiation damage

    Science.gov (United States)

    Kawai, Masayoshi; Kokawa, Hiroyuki; Okamura, Hiroshi; Kawasaki, Akira; Yamamura, Tsutomu; Hara, Nobuyoshi; Akao, Noboru; Futakawa, Masatoshi; Kikuchi, Kenji

    2006-09-01

    Materials that have strong resistance to both beam impact (or shock-wave) and radiation damage are required for the beam target of an intense accelerator and space applications. Recently, Futakawa et al. found in their experiments that Kolsterising specimens have a stronger resistance to pitting than SS316 CW. A similar effect can be expected for other hardening treatments, and new material development is hopeful. Accordingly, we have started the development of high-performance materials by organizing the project team from KEK, JAEA and universities. In this paper, the scope of the project is introduced. Recent topics involve the development of intergranular crack (IGC)-resistant austenitic stainless-steel, AlN-TiN ceramics and cladding techniques of thin tantalum or CrN film on a tungsten target by means of a molten-salt method and ion-beam-enhanced deposition. New observations on corrosion resistance are presented.

  16. Beam Loss Position Monitor Using Cerenkov Radiation in Optical Fibers

    CERN Document Server

    Körfer, M

    2005-01-01

    Single pass Free Electron Lasers SASE-FELs are developed for high brightness and short wavelength applications. The VUV-FEL at DESY will reach an average beam power of about 72 kW. To avoid particle losses in the radiation sensitive undulators a collimator system is installed. However, the proper operation of the collimator system needs to be measured with a beam loss monitor. Conventional radiation sensor systems are not suited for the VUV-FEL undulators, because the free space in the undulator gap is less than 1 mm. A Beam Loss Position Monitor (BLPM) based on Cerenkov light in optical fibers allows the monitoring of losses inside the undulator. Electrons with energies above 175 keV generate Cerenkov light during their penetration of the optical fiber. The fast response of the Cerenkov signal is detected with photomultipliers at the end of the irradiated fibers. The beam loss position along the section of interest can be determinate by exploiting the system trigger (bunch clock) of the accelerator system. T...

  17. Radiation Shielding Analysis of Electron Beam Accelerator Facility

    International Nuclear Information System (INIS)

    The objective of this technical report are to establish the radiation shielding technology of a high-energy electron accelerator to the facilities which utilize with electron beam. The technologies of electron beam irradiation(300 KeV -10 MeV) demand on the diverse areas of material processing, surface treatment, treatments on foods or food processing, improvement of metal properties, semiconductors, and ceramics, sterilization of medical goods and equipment, treatment and control of contamination and pollution, and so on. In order to acquire safety design for the protection of personnel from the radiations produced by electron beam accelerators, it is important to develop the radiation shielding analysis technology. The shielding analysis are carried out by which define source term, calculation modelling and computer calculations for 2 MeV and 10 MeV accelerators. And the shielding analysis for irradiation dump shield with 10 MeV accelerators are also performed by solving the complex 3-D geometry and long computer run time problem. The technology development of shielding analysis will be contributed to extend the further high energy accelerator development

  18. Spectral properties of Compton inverse radiation: Application of Compton beams

    Science.gov (United States)

    Bulyak, Eugene; Urakawa, Junji

    2014-05-01

    Compton inverse radiation emitted due to backscattering of laser pulses off the relativistic electrons possesses high spectral density and high energy of photons - in hard x-ray up to gamma-ray energies - because of short wavelength of laser radiation as compared with the classical electromagnetic devices such as undulators. In this report, the possibility of such radiation to monochromatization by means of collimation is studied. Two approaches have been considered for the description of the spectral-angular density of Compton radiation based on the classical field theory and on the quantum electrodynamics. As is shown, both descriptions produce similar total spectra. On the contrary, angular distribution of the radiation is different: the classical approach predicted a more narrow radiation cone. Also proposed and estimated is a method of the 'electronic' monochromatization based on the electronic subtraction of the two images produced by the electron beams with slightly different energies. A 'proof-of-principle' experiment of this method is proposed for the LUXC facility of KEK (Japan).

  19. Radiation processing of natural polymers using low energy electron beam

    International Nuclear Information System (INIS)

    Radiation processing is widely used in Japan and the economic scale of radiation application amounted to about 71 b$ (ratio relative to GDP: 1.7%) in total. It consisted of 60 b$ (85%) in industry, 10 b$ (14%) in medicine and 1 b$ (1%) in agriculture. Irradiation using gamma-ray from 60Co and electron beam is commercially used for the sterilization and modification of materials. Utilization of natural polymers by radiation has been investigated for recycling the natural resources and reducing the environmental pollution. Polysaccharides such as chitosan, sodium alginate, carrageenan, cellulose, pectin were easily degraded by irradiation and induced various kinds of biological activities, i.e. anti-bacterial activity, elicitor activity, plant growth promotion, suppression of environmental stress on plants. Radiation degraded chitosan was effective to enhance the growth of plants in tissue culture. Low energy electron beam (EB) irradiation has a variety of applications and good safety. A self-shielded low energy electron accelerator system needs an initial investment much lower than a 60Co facility. It was demonstrated that the liquid sample irradiation system using low energy EB was effective not only for the preparation of degraded polysaccharides but also for radiation vulcanization of natural rubber latex (RVNRL). Some carbohydrate derivatives, carboxymethylcellulose (CMC), carboxymethyl-starch and carboxymethyl-chitin/chitosan, can be crosslinked under certain radiation condition and produced the biodegradable hydrogel for medical and agricultural use. Treatment of soybean seeds by low energy EB enhanced the growth and the number of rhizobia on the root. (author)

  20. Response of TL materials in diagnostic radiology X radiation beams

    International Nuclear Information System (INIS)

    Full text: In diagnostic radiology, TL materials are widely used for dosimetric purposes in clinical beams. Even though the general characteristic of most materials are well documented in literature, the parameters cannot easily be compared, because they derive from different studies, each one with its particularities. Therefore, the main purpose of this study was to compare the performance of different types of TLDs in diagnostic radiology energy range, using standard beams. Seven types of TL materials were used in this study: three types of CaSO4:Dy pellets (conventional CaSO4:Dy pellets, thin CaSO4:Dy pellets, and thin CaSO4:Dy+10%C pellets), sintered Al2O3 pellets (also called Alumina), LiF:Mg,Ti (Harshaw TLD-100), CaF2:Dy (Harshaw TLD-200) and CaF2:Mn (Harshaw TLD-400). For the tests, the materials were irradiated in IEC diagnostic radiology standard beams. Several dosimetric characteristics were evaluated, such as reproducibility, sensitivity, calibration curves, lower dose limits and energy dependence. The results show that the sintered Al2O3 pellets do not have the adequate sensitivity to be used in this dose range. All other materials presented a sensitivity higher than the TLD-100 dosemeters. However, none of the materials, except TLD-100, presented flat energy dependence of response, which is in accordance with literature data. The utilization of those materials for dosimetric purposes should be associated to devices for the determination of the beam effective energy, as, for example, a TLD tandem system. It is also essential to obtain precise calibration curves, in radiation beams really similar to the clinical beams

  1. Successful beam tests for ALICE Transition Radiation Detector

    CERN Multimedia

    2002-01-01

    Another round of beam tests of prototypes for the Transition Radiation Detector (TRD) for ALICE has been completed and there are already some good results. Mass production of the components of the detector will start early next year.   Top view of the setup for the Transition Radiation Detector prototype tests at CERN.On the left, can be seen the full-scale TRD prototype together with four smaller versions. These are busy days for the TRD (Transition Radiation Detector) team of ALICE. Twenty people - mainly from Germany, but also from Russia and Japan - were working hard during the beam tests this autumn at CERN to assess the performance of their detector prototypes. Analysis of the data shows that the TRD can achieve the desired physics goal even for the highest conceivable multiplicities in lead-lead collisions at the LHC. In its final configuration in the ALICE experiment, the TRD will greatly help in identifying high-momentum electrons, which are 'needles in a haystack' that consists mostly of...

  2. Electron beam radiation effects on recycled polyamide-6

    International Nuclear Information System (INIS)

    Applications of electron beam processing in the treatment of polymers are commonly used. The interaction of high energy radiation with polymers may cause permanent modifications in the polymer's physicochemical structure. The induced modifications may result in degradation of the polymer or in improvement of its properties (crosslinking), which are simultaneous and competing processes, depending on the radiation dose utilized. Crosslinking occurs more readily in the polymer's amorphous content and this process makes the glass transition temperature (Tg) of the polymers to increase. Successive recycling cycles promote changes in polymers properties, such as breaking of structure, molecular weight reduction, melt index increase and mechanical resistance reduction. The polyamide-6 resin was recycled for three successive recycling cycles and thi polyamide-6 specimens were molded by the process of injection molding. These specimens were irradiated at the Nuclear Energetic Research Institute (IPEN) radiation facility, on a JOB 188 model accelerator, with a 1.5 MeV electron beam, doses of 200, 300, 400, 500 and 600 kGy, and dose rate of 22.61 kGy/s. The DMA tests were performed using DMA-983 equipment from TA Instruments and two heatings were adopted in order to eliminate the moisture absorption. The X-ray diffraction analysis wa carried out at the Philips PW 1830 model equipment

  3. Theory for beam-plasma millimeter-wave radiation source experiments

    International Nuclear Information System (INIS)

    This paper reports on theoretical studies for millimeter-wave plasma source experiments. In the device, millimeter-wave radiation is generated in a plasma-filled waveguide driven by counter-streaming electron beams. The beams excite electron plasma waves which couple to produce radiation at twice the plasma frequency. Physics topics relevant to the high electron beam current regime are discussed

  4. Electron beam radiation effects on recycled polyamide-6

    International Nuclear Information System (INIS)

    The aim of this work was to study the ionizing radiation effects on recycled polyamide-6. This polymer was irradiated with a 1.5 MeV electron beam at different doses. The glass transition of the samples was determined by dynamic mechanical analyses (DMA) measurements and the crystallinity was observed through the X-ray diffraction diagrams. It was observed that crosslinking may have occurred in the irradiated samples of virgin and recycled polyamide-6 and the crystallinity has not changed. (author)

  5. Radiation produced by the modulated electron beam of a free electron laser

    OpenAIRE

    Neighbours, John Robert; Maruyama, Xavier K.; Buskirk, Fred Ramon

    1986-01-01

    The electron beam in a free electron laser (FEL) becomes axially modulated at the optical wave length of the FEL radiation. This electron beam passed through a gas may produce intense Cerenkov radiation. The effects of the radial and axial dimension of the electron bunches on the radiation are explored

  6. Thin silicon strip detectors for beam monitoring in Micro-beam Radiation Therapy

    International Nuclear Information System (INIS)

    Microbeam Radiation Therapy (MRT) is an emerging cancer treatment that is currently being developed at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France. This technique uses a highly collimated and fractionated X-ray beam array with extremely high dose rate and very small divergence, to benefit from the dose-volume effect, thus sparing healthy tissue. In case of any beam anomalies and system malfunctions, special safety measures must be installed, such as an emergency safety shutter that requires continuous monitoring of the beam intensity profile. Within the 3DMiMic project, a novel silicon strip detector that can tackle the special features of MRT, such as the extremely high spatial resolution and dose rate, has been developed to be part of the safety shutter system. The first prototypes have been successfully fabricated, and experiments aimed to demonstrate their suitability for this unique application have been performed. Design, fabrication and the experimental results as well as any identified inadequacies for future optimisation are reported and discussed in this paper

  7. Thin silicon strip detectors for beam monitoring in Micro-beam Radiation Therapy

    Science.gov (United States)

    Povoli, M.; Alagoz, E.; Bravin, A.; Cornelius, I.; Bräuer-Krisch, E.; Fournier, P.; Hansen, T. E.; Kok, A.; Lerch, M.; Monakhov, E.; Morse, J.; Petasecca, M.; Requardt, H.; Rosenfeld, A. B.; Röhrich, D.; Sandaker, H.; Salomé, M.; Stugu, B.

    2015-11-01

    Microbeam Radiation Therapy (MRT) is an emerging cancer treatment that is currently being developed at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France. This technique uses a highly collimated and fractionated X-ray beam array with extremely high dose rate and very small divergence, to benefit from the dose-volume effect, thus sparing healthy tissue. In case of any beam anomalies and system malfunctions, special safety measures must be installed, such as an emergency safety shutter that requires continuous monitoring of the beam intensity profile. Within the 3DMiMic project, a novel silicon strip detector that can tackle the special features of MRT, such as the extremely high spatial resolution and dose rate, has been developed to be part of the safety shutter system. The first prototypes have been successfully fabricated, and experiments aimed to demonstrate their suitability for this unique application have been performed. Design, fabrication and the experimental results as well as any identified inadequacies for future optimisation are reported and discussed in this paper.

  8. PIC code KARAT simulation of different types of polarization radiation generated by relativistic electron beam

    Science.gov (United States)

    Artyomov, K. P.; Ryzhov, V. V.; Naumenko, G. A.; Shevelev, M. V.

    2012-05-01

    Different types of polarization radiation generated by a relativistic electron beam are simulated using fully electromagnetic particle-in-cell (PIC) code KARAT. The simulation results for diffraction radiation, transition radiation, Smith-Purcell radiation and Vavilov-Cherenkov radiation are in a good agreement with experimental data and analytical models. Modern PIC simulation is a good tool to check and predict experimental results.

  9. PIC code KARAT simulation of different types of polarization radiation generated by relativistic electron beam

    International Nuclear Information System (INIS)

    Different types of polarization radiation generated by a relativistic electron beam are simulated using fully electromagnetic particle-in-cell (PIC) code KARAT. The simulation results for diffraction radiation, transition radiation, Smith-Purcell radiation and Vavilov-Cherenkov radiation are in a good agreement with experimental data and analytical models. Modern PIC simulation is a good tool to check and predict experimental results.

  10. Radiation Exposure of Abdominal Cone Beam Computed Tomography

    International Nuclear Information System (INIS)

    PurposeTo evaluate patients radiation exposure of abdominal C-arm cone beam computed tomography (CBCT).MethodsThis prospective study was approved by the institutional review board; written, informed consent was waived. Radiation exposure of abdominal CBCT was evaluated in 40 patients who underwent CBCT during endovascular interventions. Dose area product (DAP) of CBCT was documented and effective dose (ED) was estimated based on organ doses using dedicated Monte Carlo simulation software with consideration of X-ray field location and patients’ individual body weight and height. Weight-dependent ED per DAP conversion factors were calculated. CBCT radiation dose was compared to radiation dose of procedural fluoroscopy. CBCT dose-related risk for cancer was assessed.ResultsMean ED of abdominal CBCT was 4.3 mSv (95 % confidence interval [CI] 3.9; 4.8 mSv, range 1.1–7.4 mSv). ED was significantly higher in the upper than in the lower abdomen (p = 0.003) and increased with patients’ weight (r = 0.55, slope = 0.045 mSv/kg, p < 0.001). Radiation exposure of CBCT corresponded to the radiation exposure of on average 7.2 fluoroscopy minutes (95 % CI 5.5; 8.8 min) in the same region of interest. Lifetime risk of exposure related cancer death was 0.033 % or less depending on age and weight.ConclusionsMean ED of abdominal CBCT was 4.3 mSv depending on X-ray field location and body weight

  11. Radiation Exposure of Abdominal Cone Beam Computed Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Sailer, Anna M., E-mail: anni.sailer@mumc.nl [Maastricht University Medical Centre (MUMC), Department of Radiology (Netherlands); Schurink, Geert Willem H., E-mail: gwh.schurink@mumc.nl [Maastricht University Medical Centre, Department of Surgery (Netherlands); Wildberger, Joachim E., E-mail: j.wildberger@mumc.nl; Graaf, Rick de, E-mail: r.de.graaf@mumc.nl; Zwam, Willem H. van, E-mail: w.van.zwam@mumc.nl; Haan, Michiel W. de, E-mail: m.de.haan@mumc.nl; Kemerink, Gerrit J., E-mail: gerrit.kemerink@mumc.nl; Jeukens, Cécile R. L. P. N., E-mail: cecile.jeukens@mumc.nl [Maastricht University Medical Centre (MUMC), Department of Radiology (Netherlands)

    2015-02-15

    PurposeTo evaluate patients radiation exposure of abdominal C-arm cone beam computed tomography (CBCT).MethodsThis prospective study was approved by the institutional review board; written, informed consent was waived. Radiation exposure of abdominal CBCT was evaluated in 40 patients who underwent CBCT during endovascular interventions. Dose area product (DAP) of CBCT was documented and effective dose (ED) was estimated based on organ doses using dedicated Monte Carlo simulation software with consideration of X-ray field location and patients’ individual body weight and height. Weight-dependent ED per DAP conversion factors were calculated. CBCT radiation dose was compared to radiation dose of procedural fluoroscopy. CBCT dose-related risk for cancer was assessed.ResultsMean ED of abdominal CBCT was 4.3 mSv (95 % confidence interval [CI] 3.9; 4.8 mSv, range 1.1–7.4 mSv). ED was significantly higher in the upper than in the lower abdomen (p = 0.003) and increased with patients’ weight (r = 0.55, slope = 0.045 mSv/kg, p < 0.001). Radiation exposure of CBCT corresponded to the radiation exposure of on average 7.2 fluoroscopy minutes (95 % CI 5.5; 8.8 min) in the same region of interest. Lifetime risk of exposure related cancer death was 0.033 % or less depending on age and weight.ConclusionsMean ED of abdominal CBCT was 4.3 mSv depending on X-ray field location and body weight.

  12. Radiation Safety System for SPIDER Neutral Beam Accelerator

    Science.gov (United States)

    Sandri, S.; Coniglio, A.; D'Arienzo, M.; Poggi, C.

    2011-12-01

    SPIDER (Source for Production of Ion of Deuterium Extracted from RF Plasma only) and MITICA (Megavolt ITER Injector Concept Advanced) are the ITER neutral beam injector (NBI) testing facilities of the PRIMA (Padova Research Injector Megavolt Accelerated) Center. Both injectors accelerate negative deuterium ions with a maximum energy of 1 MeV for MITICA and 100 keV for SPIDER with a maximum beam current of 40 A for both experiments. The SPIDER facility is classified in Italy as a particle accelerator. At present, the design of the radiation safety system for the facility has been completed and the relevant reports have been presented to the Italian regulatory authorities. Before SPIDER can operate, approval must be obtained from the Italian Regulatory Authority Board (IRAB) following a detailed licensing process. In the present work, the main project information and criteria for the SPIDER injector source are reported together with the analysis of hypothetical accidental situations and safety issues considerations. Neutron and photon nuclear analysis is presented, along with special shielding solutions designed to meet Italian regulatory dose limits. The contribution of activated corrosion products (ACP) to external exposure of workers has also been assessed. Nuclear analysis indicates that the photon contribution to worker external exposure is negligible, and the neutron dose can be considered by far the main radiation protection issue. Our results confirm that the injector has no important radiological impact on the population living around the facility.

  13. Radiation Safety System for SPIDER Neutral Beam Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Sandri, S.; Poggi, C. [ENEA, Radiation Protection Institute, IRP-FUAC, Frascati (Italy); Coniglio, A. [Medical Physics Department, S. Giovanni Calibita Hospital, Fatebenefratelli, Isola Tiberina, Roma (Italy); D' Arienzo, M. [ENEA, Ionizing Radiation Metrology National Institute, METR, Casaccia, Rome (Italy)

    2011-12-13

    SPIDER (Source for Production of Ion of Deuterium Extracted from RF Plasma only) and MITICA (Megavolt ITER Injector Concept Advanced) are the ITER neutral beam injector (NBI) testing facilities of the PRIMA (Padova Research Injector Megavolt Accelerated) Center. Both injectors accelerate negative deuterium ions with a maximum energy of 1 MeV for MITICA and 100 keV for SPIDER with a maximum beam current of 40 A for both experiments. The SPIDER facility is classified in Italy as a particle accelerator. At present, the design of the radiation safety system for the facility has been completed and the relevant reports have been presented to the Italian regulatory authorities. Before SPIDER can operate, approval must be obtained from the Italian Regulatory Authority Board (IRAB) following a detailed licensing process. In the present work, the main project information and criteria for the SPIDER injector source are reported together with the analysis of hypothetical accidental situations and safety issues considerations. Neutron and photon nuclear analysis is presented, along with special shielding solutions designed to meet Italian regulatory dose limits. The contribution of activated corrosion products (ACP) to external exposure of workers has also been assessed. Nuclear analysis indicates that the photon contribution to worker external exposure is negligible, and the neutron dose can be considered by far the main radiation protection issue. Our results confirm that the injector has no important radiological impact on the population living around the facility.

  14. Cone Beam CT: radiation protection aspects and quality control

    International Nuclear Information System (INIS)

    The technology related to Cone Beam Computed Tomography (CBCT) give three-dimensional (3D) diagnostic results. It allows to give to the patient doses much lower than traditional TC technique. This type of equipment, introduced relatively recently, is rapidly spreading in the field of Radiology and in particular dental and maxillofacial and is meant to be used more and more frequently in clinical practice and in the coming years there will be an increase of radiological examinations performed with this technique. In January 2012 the ANPEQ formed, within the Permanent Commission's technical aspects of radiation protection-health ' the Working Party ' Cone Beam CT ' with the intention to draw up an operating report that provide guidelines for radiological protection of the operators and of the population, in full respect of the relevant operating areas by other operators, such as physicists, doctors etc. In the course of work it is proved the opportunity to share what worked with other associations dealing with radiation protection, AIFM (Associazione Italiana di Fisica Medica), AIRP (Associazione Italiana di Radioprotezione), AIRM (Associazione Italiana di Radioprotezione Medica), organising a joint Conference on CBCT which was held at pisa on March 1, 2013. This report collects most of the contributions presented by individual speakers who participated in the Conference, by then state of the art in this innovative method.

  15. Normal tissue tolerance to external beam radiation therapy: The vagina

    International Nuclear Information System (INIS)

    The vagina is a virtual cavity involved in sexual reproduction field. Due to its anatomical location, it may be exposed in whole or in part to ionizing radiation in external radiotherapy and/or brachytherapy of the pelvic region. This review aims to describe the vaginal acute and late side effects due to radiation, probably inadequately reported in the literature. Medline and PubMed literature searches were performed using the keywords -vaginal - radiotherapy - toxicity. The acute and late functional changes after external beam radiation consist mainly of drought. Their incidences are poorly described in the literature and the delivered doses even less. Recommendations are non-existent as the normal tissue complication probability (NTCP). Brachytherapy delivers high and heterogeneous doses, making it difficult to estimate the dose. The concomitant administration of chemotherapy appears to be a factor increasing the risk of toxicity. Modern techniques of conformal radiotherapy with modulated intensity appear to have little impact on this body. Only a maximum dose on each third of the vagina appears to be currently proposed to avoid the risk of side effects. (authors)

  16. The Beaming Pattern of Doppler Boosted Thermal Annihilation Radiation: Application to MeV Blazars

    OpenAIRE

    Skibo, J. G.; Dermer, C. D.; Schlickeiser, R.

    1997-01-01

    The beaming pattern of thermal annihilation radiation is broader than the beaming pattern produced by isotropic nonthermal electrons and positrons in the jets of radio-emitting active galactic nuclei which Compton scatter photons from an external isotropic radiation field. Thus blueshifted thermal annihilation radiation can provide the dominant contribution to the high-energy radiation spectrum at observing angles theta > 1/Gamma, where Gamma is the bulk Lorentz factor of the outflowing plasm...

  17. Easy graphical display of beam directions in three-dimensional converging radiation therapy. Proposal for a radiation map

    International Nuclear Information System (INIS)

    In stereotactic radiosurgery, non-coplanar isocentric beams are employed to concentrate the dose distribution on the planning target volume (PTV). However, the directions of incident beams must be determined with great care by using a digitally reconstructed beam's eye view (BEV) to prevent the irradiation of organs at risk. We present a new method of 2-dimensional graphical representation (radiation map) to facilitate the understanding of 3-dimensional relationships between incident beams and critical organs. After determining the isocenter and beam diameter, beam directions and critical organs are projected onto the imaginary sphere centered on the isocenter. The coordinate of the beam directions and the organs at risk can be expressed by latitude and longitude on the sphere. The contours of the organs at risk are displayed with a margin of the radius of the radiation beam. Mirror images of the critical organs are also displayed to prevent irradiation by the opposing beams. The radiation map could be produced within 5 minutes using a workstation. Radiation maps, like DVH, will be very useful in the evaluation of radiation treatment planning. (author)

  18. Performance of ionization chambers in X radiation beams, radioprotection level

    International Nuclear Information System (INIS)

    Narrow beams, radioprotection level, were implanted in an X ray system, based on ISO 4037-1, as recommended by IAEA (SRS 16). Energy dependency tests were carried out and short-term stability in ionization chambers for use in radiation protection of trademark Physikalisch-Technische Werkstaetten (PTW), 32002 and 23361 models. The ionization chambers were studied with regard to short-term stability within the program of quality control of the laboratory, with a 90Sr + 90Y. The results of the short-term stability test were compared with the recommendations of IEC 60731, respect to dosemeters used in radiotherapy, since this standard presents the more restrictive limits with regard to the behaviour of ionization chambers. All cameras showed results within the limits recommended by this standard. With respect to the energy dependency of the response, the model Chamber 32002 presented a maximum dependence of only 2.7%, and the model Chamber 23361, 4.5%

  19. The dynamical dipole radiation in dissipative collisions with exotic beams

    International Nuclear Information System (INIS)

    Heavy Ion Collisions (HIC) represent a unique tool to probe the in-medium nuclear interaction in regions away from saturation. In this work we present a selection of reaction observables in dissipative collisions particularly sensitive to the isovector part of the interaction, i.e. to the symmetry term of the nuclear Equation of State (EoS). At low energies the behavior of the symmetry energy around saturation influences dissipation and fragment production mechanisms. We will first discuss the recently observed Dynamical Dipole Radiation, due to a collective neutron-proton oscillation during the charge equilibration in fusion and deep-inelastic collisions. We will review in detail all the main properties, yield, spectrum, damping and angular distributions, revealing important isospin effects. Reactions induced by unstable 132Sn beams appear to be very promising tools to test the sub-saturation Isovector EoS. Predictions are also presented for deep-inelastic and fragmentation collisions induced by neutron rich projectiles. The importance of studying violent collisions with radioactive beams at low and Fermi energies is finally stressed. (author)

  20. Radiation sterilization of fluoroquinolones in solid state: Investigation of effect of gamma radiation and electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Babita K., E-mail: singhbab2001@rediffmail.co [Department of Chemistry, RTM Nagpur University Campus, Amravati Road, Nagpur 440033 (India); Central Forensic Science Laboratory, Ramanthapur, Hyderabad 500013 (India); Parwate, Dilip V. [Department of Chemistry, RTM Nagpur University Campus, Amravati Road, Nagpur 440033 (India); Dassarma, Indrani B. [Jhulelal Institute of Technology, Nagpur (India); Shukla, Sudhir K. [Central Forensic Science Laboratory, Ramanthapur, Hyderabad 500013 (India)

    2010-09-15

    The effect of gamma radiation from {sup 60}Co source and 2 MeV electron beam was studied on two fluoroquinolone antibiotics viz norfloxacin and gatifloxacin in the solid state. The changes in reflectance spectrum, yellowness index, vibrational characteristics, thermal behavior, UV spectrum, chemical potency (HPLC) and microbiological potency were investigated. ESR measurement gave the number of free radical species formed and their population. The nature of final radiolytic impurities was assessed by studying the HPLC impurity profile. Both norfloxacin and gatifloxacin were observed to be radiation resistant, and did not show significant changes in their physico-chemical properties. They could be radiation sterilized at a dose of 25 kGy.

  1. Normal tissue tolerance to external beam radiation therapy: Small bowel

    International Nuclear Information System (INIS)

    The small bowel is a hollow organ involved in the transit and absorption of food. In relation to its anatomical location, a significant amount of this organ is exposed in whole or in part to ionizing radiation in external radiotherapy during abdominal or pelvic irradiation either for primary cancers or metastasis. The acute functional changes during external beam radiation are mainly leading to diarrhea, abdominal pain and bloating. The main late side effects of irradiation of the small intestine are chronic diarrhea, malabsorption with steatorrhoea, abdominal spasms, intestinal obstruction, bleeding and fistulas. The architecture of the small intestine may be considered as parallel with a significant correlation between the irradiated volume of small bowel and the likelihood of acute toxicity, whatever the dose. The literature analysis recommends to consider the volume of small bowel receiving 15 Gy (threshold of 100 to 200 cm3) but also 30 and 50 Gy (thresholds of 35 to 300 cm3, depending on the level of dose considered). Modern techniques of conformal radiotherapy with modulated intensity will probably have beneficial impact on small bowel toxicity. (authors)

  2. Study of Synchrotron Radiation for the Electron Beam Polarimeter for the MEIC

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, M. [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-08-06

    This is a look at the synchrotron radiation coming from the chicane in the electron beam line for the MEIC design. The power density on the beam pipe as well as transmission through the beam pipe is studied. The optics design is version 12.

  3. Design, construction and characterization of special ionization chambers for X radiation beams monitoring

    International Nuclear Information System (INIS)

    X radiation equipment may show fluctuations in the radiation beam intensity, as they are connected to the power net. These intensity variations can, in turn, modify the air kerma rate produced by this radiation beam. In a calibration laboratory, where radiation detectors (from clinics and hospital services) are calibrated, variations in the radiation beam intensity may cause an error in the absorbed dose determination. The monitor ionization chambers are used to verify the radiation beam intensity constancy, and to provide a correction for possible fluctuations. In this work, monitor ionization chambers for X radiation beams were designed, assembled and characterized. The developed ionization chambers have an innovative design, ring-shaped, with aluminium or graphite electrodes. These ring-shaped ionization chambers have the advantage of not interfering in the direct radiation beams. A double-volume ionization chamber with graphite electrodes was also developed. This ionization chamber is similar to the commercial monitor ionization chamber used in the Calibration Laboratory of the Instituto de Pesquisas Energeticas e Nucleares. All developed ionization chambers were tested in several standardized radiation beams and their performances were compared with those of commercial ionization chambers. The results show that two of the four ionization chambers developed showed performance comparable to that of the commercial ionization chambers tested. Besides presenting good results, the ionization chambers were designed and manufactured using low cost materials, which are easily found on the Brazilian market. (author)

  4. Spontaneous short-wave radiation of high-current electron beam

    International Nuclear Information System (INIS)

    Angular and spectral characteristics of spontaneous radiation of high-current electron beam in a proper magnetic field are theoretically investigated. The model of a cylindrically- symmetric non rotating stationary beam the space charge of which is completely compensated by a motionless ion background has been used. It is shown that the radiation considerably depends on the beam current, its directivity with current increase drops, total intensity grows, but the spectrum widens

  5. Imaging and characterization of primary and secondary radiation in ion beam therapy

    Science.gov (United States)

    Granja, Carlos; Martisikova, Maria; Jakubek, Jan; Opalka, Lukas; Gwosch, Klaus

    2016-07-01

    Imaging in ion beam therapy is an essential and increasingly significant tool for treatment planning and radiation and dose deposition verification. Efforts aim at providing precise radiation field characterization and online monitoring of radiation dose distribution. A review is given of the research and methodology of quantum-imaging, composition, spectral and directional characterization of the mixed-radiation fields in proton and light ion beam therapy developed by the IEAP CTU Prague and HIT Heidelberg group. Results include non-invasive imaging of dose deposition and primary beam online monitoring.

  6. Design Specifications for a Radiation Tolerant Beam Loss Measurement ASIC

    CERN Document Server

    Venturini, G G; Effinger, E; Zamantzas, C

    2009-01-01

    A novel radiation-hardened current digitizer ASIC is in planning stage, aimed at the acquisition of the current signals from the ionization chambers employed in the Beam Loss Monitoring system at CERN. The purpose is to match and exceed the performance of the existing discrete component design, currently in operation in the Large Hadron Collider (LHC). The specifications include: a dynamic range of nine decades, defaulting to the 1 pA-1mA range but adjustable by the user, ability to withstand a total integrated dose of 10 kGy at least in 20 years of operation and user selectable integrating windows, as low as 500 ns. Moreover, the integrated circuit should be able to digitize currents of both polarity with a minimum number of external components and without needing any configuration. The target technology is the IBM 130nm CMOS process. The specifications, the architecture choices and the reasons on which they are based upon are discussed in this paper.

  7. Guiding of Laser Beams in Plasmas by Radiation Cascade Compression

    International Nuclear Information System (INIS)

    The near-resonant heatwave excitation of an electron plasma wave (EPW) can be employed for generating trains of few-fs electromagnetic pulses in rarefied plasmas. The EPW produces a co-moving index grating that induces a laser phase modulation at the beat frequency. Consequently, the cascade of sidebands red- and blue-shifted from the fundamental by integer multiples of the beat frequency is generated in the laser spectrum. When the beat frequency is lower than the electron plasma frequency, the phase chirp enables laser beatnote compression by the group velocity dispersion [S. Kalmykov and G. Shvets, Phys. Rev. E 73, 046403 (2006)]. In the 3D cylindrical geometry, the frequency-downshifted EPW not only modulates the laser frequency, but also causes the pulse to self-focus [P. Gibbon, Phys. Fluids B 2, 2196 (1990)]. After self-focusing, the multi-frequency laser beam inevitably diverges. Remarkably, the longitudinal beatnote compression can compensate the intensity drop due to diffraction. A train of high-intensity radiation spikes with continually evolving longitudinal profile can be self-guided over several Rayleigh lengths in homogeneous plasmas. High amplitude of the EPW is maintained over the entire propagation length. Numerical experiments on the electron acceleration in the cascade-driven (cascade-guided) EPW [using the code WAKE by P. Mora and T. M. Antonsen Jr., Phys. Plasmas 4, 217 (1997)] show that achieving GeV electron energy is possible under realistic experimental parameters

  8. Characterization of scatter radiation in cone beam CT mammography

    Science.gov (United States)

    Liu, Bob; Glick, Stephen J.; Groiselle, Corinne

    2005-04-01

    Cone beam CT mammography (CBCTM) is an emerging breast imaging technology and is currently under intensive investigation [1-3]. One of the major challenges in CBCTM is to understand the characteristics of scatter radiation and to find ways to reduce or correct its degrading effects. Since the breast shape, geometry and image formation process are significantly different from conventional mammography, all system components and parameters such as target/filter combination, kVp range, source to image distance, detector design etc. should be examined and optimized. In optimizing CBCTM systems, it is important to have knowledge of how different imaging parameters affect the recorded scatter within the image. In this study, a GEANT4 based Monte Carlo simulation package (GATE) was used to investigate the scatter magnitude and its" distribution in CBCTM. The influences of different air gaps, kVp settings, breast sizes and breast composition on the scatter primary ratio (SPR) and scatter profiles were examined. In general, the scatter to primary ratio (SPR) is strongly dependent on the breast size and air gap, and is only moderately dependent on the kVp setting and breast composition. These results may be used for optimization of CBCTM systems, as well as for developing scatter correction methods.

  9. Assessment of the environment using synchrotron radiation micro-beams

    International Nuclear Information System (INIS)

    The pollution from heavy metals such as lead and mercury has been a matter of great concern for decades as they may cause adverse health to human. In this study, we analyzed major and trace elements in modern and prehistoric teeth by X-ray fluorescence (XRF) analysis using synchrotron radiation micro-beams, in order to assess the changes of the environment through the civilization and the industrialization and their effects on human. Teeth from various periods of time including teeth from the human remains of the Jomon period were collected for the analysis as teeth are suggested to be indicators of the environmental changes. The main elements analyzed were Pb, Hg, Cu, and Zinc. Levels of Pb in modern teeth were higher than those in the Jomon teeth which indicate that the pollution from Pb is now greater than it was in the remote past. However, as there are small numbers of teeth collected in this study, there is a need to analyze more samples from various periods of time in order to assess the change of the environment in details

  10. Off-axial acoustic radiation force of repulsor and tractor bessel beams on a sphere.

    Science.gov (United States)

    Silva, Glauber T; Lopes, J Henrique; Mitri, Farid G

    2013-06-01

    Acoustic Bessel beams are known to produce an axial radiation force on a sphere centered on the beam axis (on-axial configuration) that exhibits both repulsor and tractor behaviors. The repulsor and the tractor forces are oriented along the beam's direction of propagation and opposite to it, respectively. The behavior of the acoustic radiation force generated by Bessel beams when the sphere lies outside the beam's axis (off-axial configuration) is unknown. Using the 3-D radiation force formulas given in terms of the partial wave expansion coefficients for the incident and scattered waves, both axial and transverse components of the force exerted on a silicone- oil sphere are obtained for a zero- and a first-order Bessel vortex beam. As the sphere departs from the beam's axis, the tractor force becomes weaker. Moreover, the behavior of the transverse radiation force field may vary with the sphere's size factor ka (where k is the wavenumber and a is the sphere radius). Both stable and unstable equilibrium regions around the beam's axis are found, depending on ka values. These results are particularly important for the design of acoustical tractor beam devices operating with Bessel beams. PMID:25004483

  11. Aspects on the optimal photon beam energy for radiation therapy

    International Nuclear Information System (INIS)

    The selection of optimal photon beam energy is investigated both for realistic clinical bremsstrahlung beams and for monoenergetic photon beams. The photon energies covered in this investigation range from 60Co to bremsstrahlung and monoenergetic beams with maximum energies up to 50 MeV. One head and neck tumor and an advanced cervix tumor are investigated and the influence of beam direction is considered. It is shown that the use of optimized intensity modulated photon beams significantly reduces the need of beam energy selection. The most suitable single accelerator potential will generally be in the range 6-15 MV for both superficially located and deep-seated targets, provided intensity-modulated dose delivery is employed. It is also shown that a narrow penumbra region of a photon beam ideally should contain low-energy photons (≤4 MV), whereas the gross tumor volume, particularly when deep-seated targets are concerned, should be irradiated by high-energy photons. The regions where low photon energies are most beneficial are where organs at risk are laterally close to the target volume. The situation is completely changed when uniform or wedged beams are used. The selection of optimal beam energy then becomes a very important task in line with the experience from traditional treatment techniques. However, even with a large number of uniform beam portals, the treatment outcome is substantially lower than with a few optimized intensity-modulated beams. (orig.)

  12. Development of modulated electron beam for intensity modulated radiation therapy (IMRT) on a photocathode electron gun

    International Nuclear Information System (INIS)

    Radiation therapy of cancer is developing to un-uniform irradiation, for concentrating dose to a cancer tumor and reducing dose to normal tissue. As a step toward the Intensity modulated radiation therapy, we examined dynamic optical modulation of electron beam produced by a photocathode electron gun. Images on photo-masks were transferred onto a photocathode by relay imaging. Electron beam could be controlled by a remote mirror. Modulated electron beam maintained its shape on acceleration, had a fine spatial resolution, and could be moved dynamically by optical methods. As a second step, optical modulation of electron beam and dynamic control succeeded by a digital micro mirror device (DMD). (author)

  13. EFFECT OF ELECTRON BEAM RADIATIONS ON ANXIETY IN EXPERIMENTAL ANIMAL MODELS

    OpenAIRE

    Deepa B; Shyamjith Manikkoth

    2015-01-01

    Objectives: The aim of the study was to test the effect of whole body electron beam radiation on anxiety statein Swiss albino mice. Methods: Mice were irradiated with three different doses (2Gy,4Gy,6Gy)of electron beam radiations.After 24hours of radiation exposure animals were taken for testing level of anxiety using elevated plus maze and light dark arena apparatus. Results: Whole body electron beam irradiation at doses of 2, 4 and 6Gy lead to significant (p

  14. Experimental study of acoustic radiation force of an ultrasound beam on absorbing and scattering objects

    Energy Technology Data Exchange (ETDEWEB)

    Nikolaeva, Anastasiia V., E-mail: niko200707@mail.ru; Kryzhanovsky, Maxim A.; Tsysar, Sergey A. [Department of Acoustics, Physics Faculty, Moscow State University, Leninskie Gory, Moscow 119991 (Russian Federation); Kreider, Wayne [Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th St. Seattle WA 98105 (United States); Sapozhnikov, Oleg A. [Department of Acoustics, Physics Faculty, Moscow State University, Leninskie Gory, Moscow 119991 (Russian Federation); Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th St. Seattle WA 98105 (United States)

    2015-10-28

    Acoustic radiation force is a nonlinear acoustic effect caused by the transfer of wave momentum to absorbing or scattering objects. This phenomenon is exploited in modern ultrasound metrology for measurement of the acoustic power radiated by a source and is used for both therapeutic and diagnostic sources in medical applications. To calculate radiation force an acoustic hologram can be used in conjunction with analytical expressions based on the angular spectrum of the measured field. The results of an experimental investigation of radiation forces in two different cases are presented in this paper. In one case, the radiation force of an obliquely incident ultrasound beam on a large absorber (which completely absorbs the beam) is considered. The second case concerns measurement of the radiation force on a spherical target that is small compared to the beam diameter.

  15. Experimental study of acoustic radiation force of an ultrasound beam on absorbing and scattering objects

    International Nuclear Information System (INIS)

    Acoustic radiation force is a nonlinear acoustic effect caused by the transfer of wave momentum to absorbing or scattering objects. This phenomenon is exploited in modern ultrasound metrology for measurement of the acoustic power radiated by a source and is used for both therapeutic and diagnostic sources in medical applications. To calculate radiation force an acoustic hologram can be used in conjunction with analytical expressions based on the angular spectrum of the measured field. The results of an experimental investigation of radiation forces in two different cases are presented in this paper. In one case, the radiation force of an obliquely incident ultrasound beam on a large absorber (which completely absorbs the beam) is considered. The second case concerns measurement of the radiation force on a spherical target that is small compared to the beam diameter

  16. Radiation safety aspects of the operation of first three synchrotron beam lines of Indus-2.

    Science.gov (United States)

    Nayak, M K; Nair, Haridas G; Bakshi, A K; Sahani, P K; Singh, Sunil; Khan, Saleem; Verma, Dimple; Dev, Vipin; Sahu, T K; Khare, Mukesh; Kumar, Vijay; Bandyopadhyay, Tapas; Tripathi, R M; Sharma, D N

    2015-04-01

    Five synchrotron radiation beam lines are commissioned and now under regular operation at the Synchrotron Radiation Source, Indus-2 at Raja Ramanna Centre For Advanced Technology (RRCAT), Indore, India. Nine beam lines are under trial operation, and six beam lines are in the installation stage. In the early phase of installation of beam lines on Indus-2, three bending magnet beam lines, Extended X-ray Absorption Fine Structure (EXAFS, BL-8), Energy Dispersive X-ray Diffraction (EDXRD, BL-11) and Angle Dispersive X-ray Diffraction (ADXRD, BL-12), were installed and commissioned, after approval from Atomic Energy Regulatory Board (AERB), India. These beam lines are pink (BL-8), white (BL-11) and monochromatic (BL-12), which are housed in specially designed shielded hutches. In order to ensure safety of users and other working personnel from ionizing radiations present in these beam lines, several safety systems are incorporated and safety procedures are followed. The paper describes the radiological safety aspects of the three beam lines during its initial commissioning trials and also the measurements on radiation levels carried out in and around the beam line hutches. PMID:25209995

  17. Cone beam computed tomography radiation dose and image quality assessments.

    Science.gov (United States)

    Lofthag-Hansen, Sara

    2010-01-01

    Diagnostic radiology has undergone profound changes in the last 30 years. New technologies are available to the dental field, cone beam computed tomography (CBCT) as one of the most important. CBCT is a catch-all term for a technology comprising a variety of machines differing in many respects: patient positioning, volume size (FOV), radiation quality, image capturing and reconstruction, image resolution and radiation dose. When new technology is introduced one must make sure that diagnostic accuracy is better or at least as good as the one it can be expected to replace. The CBCT brand tested was two versions of Accuitomo (Morita, Japan): 3D Accuitomo with an image intensifier as detector, FOV 3 cm x 4 cm and 3D Accuitomo FPD with a flat panel detector, FOVs 4 cm x 4 cm and 6 cm x 6 cm. The 3D Accuitomo was compared with intra-oral radiography for endodontic diagnosis in 35 patients with 46 teeth analyzed, of which 41 were endodontically treated. Three observers assessed the images by consensus. The result showed that CBCT imaging was superior with a higher number of teeth diagnosed with periapical lesions (42 vs 32 teeth). When evaluating 3D Accuitomo examinations in the posterior mandible in 30 patients, visibility of marginal bone crest and mandibular canal, important anatomic structures for implant planning, was high with good observer agreement among seven observers. Radiographic techniques have to be evaluated concerning radiation dose, which requires well-defined and easy-to-use methods. Two methods: CT dose index (CTDI), prevailing method for CT units, and dose-area product (DAP) were evaluated for calculating effective dose (E) for both units. An asymmetric dose distribution was revealed when a clinical situation was simulated. Hence, the CTDI method was not applicable for these units with small FOVs. Based on DAP values from 90 patient examinations effective dose was estimated for three diagnostic tasks: implant planning in posterior mandible and

  18. Electron beam characterizations with optical diffraction radiation from circular aperture and rectangular slit

    International Nuclear Information System (INIS)

    Diffraction radiation (DR) is one of the most promising candidates for electron beam diagnostics for the high-energy accelerator facilities due to non-intercepting, multi-parameter and real-time capabilities. In this paper we investigated the possibility of using DR from circular aperture target to characterize electron beam parameters. The method to separate beam's divergence and beam size with two wavelengths components is discussed. A new method suitable for small beam size determination with DR from rectangular slit by scanning the slit in transverse direction is proposed

  19. Beam characteristics of mixed gamma-neutron radiation from IBR 30 reactor

    International Nuclear Information System (INIS)

    Measurements were carried out in the pulsed fast reactor IBR-30 experimental channels aimed at verifying the properties of different types of detectors in the mixed gamma-neutron field and obtaining information on neutron beam, such as the neutron beam homogeneity, thermal neutron fluence, neutron beam dosimetric characteristic and the relative proportion of gamma rays in the mixed gamma and neutron radiation. The information on gamma radiation and thermal neutron fluence were obtained using different thermoluminescent materials. Several solid state track detectors were used as fast neutron dosemeters. The results show that the properties of the detectors described permit their application in finding the characteristics of the individual components of mixed neutron and gamma radiation fields. It was found that the neutron component prevailed in the IBR-30 reactor neutron beam and that the beam was homogeneous along the entire channel cross section. (J.B.)

  20. Radiation processing of Nylon 6 by e-beam for improved properties and performance

    International Nuclear Information System (INIS)

    Percent water absorption of Nylon 6 was reduced substantially when irradiated by e-beam radiation in presence of triallyl isocyanurate. Hardness, tensile strength, flexural strength, and impact resistance of Nylon 6 were also improved with the dose of e-beam radiation. Improvement of mechanical properties and reduction of water absorption were due to the cross-linking of polyamide molecules in the presence of high-energy radiation. Increase of cross-linking with increasing radiation dose was verified by the increase of gel content at higher doses

  1. LCLS Spontaneous Radiation with Reflection along the Beam Line in the Undulator Pipes

    Energy Technology Data Exchange (ETDEWEB)

    2010-12-07

    Monte Carlo simulations of the spontaneous radiation at low and high energies up to the Near Experimental Hall entrance yield beam widths for use in the design of transport and diagnostic instruments in the Front End Enclosure.

  2. Theoretical and experimental study of an energy-reinforced braking radiation photon beam

    International Nuclear Information System (INIS)

    This research thesis reports the theoretical study of a photon beam raised towards high energies, its experimental implementation, the definition of a gamma spectrometry method which aimed at checking various hypotheses used in the beam theoretical study. After a presentation of the theory of phenomena of electron braking radiation, of materialisation of photons into positon-negaton pair, and of issues related to multiple Coulomb diffusion, the author reports the study of the different solutions which allow a photon beam to be obtained. A braking radiation of mono-kinetic electron has been used. This braking radiation is reinforced by absorption of low energy protons in a column of lithium hydride. The author describes how the beam is built up, and the experimental approach. He describes how raw data are processed to get rid of the influence of the multiple Coulomb diffusion and of the braking radiation. Experimental results are compared with those obtained by convolution of photon spectra and differential cross section

  3. Optical Transition Radiation Measurement of Electron Beam for Beijing Free Electron Laser

    Institute of Scientific and Technical Information of China (English)

    ZHAO Qiang; XIE Jia-Lin; LI Yong-Gui; ZHUANG Jie-Jia

    2001-01-01

    We used transition radiation techniques instead of the original phosphor targets to improve the electronic beam diagnostic system at Beijing Free Electron Laser. The beam profile, size (3.3 × 2.4 mm), position and divergence angle (σrms = 2.5 mrad) in transverse have been obtained from optical transition radiation. We also present the experimental set-up and some preliminary results.

  4. Electron beam radiation induced oxidative stress on alteration of enzymatic antioxidant status of Swiss albino mice

    International Nuclear Information System (INIS)

    Ionizing radiation causes damage to living tissues through a series of molecular events, such as photoelectric, Compton and Auger effects, depending on the radiation energy. Because human tissues contain 80% water, the major radiation damage is due to the aqueous free radicals, generated by the action of radiation on water. It was found to be 10 Gy was the lethal dose for mice. Different dosages (4 Gy, 6 Gy and 8 Gy) of electron beam radiation were used to study the level of lipid peroxidation and enzymatic antioxidant status of irradiated mice. The results showed higher the radiation dosage, increased lipid peroxidation and decreased antioxidant level. (author)

  5. Possibilities of optical transition radiation using for the U-70 and the UNR proton beam diagnostics

    International Nuclear Information System (INIS)

    Experimental results for optical transition radiation (OTR) of 70 GeV protons have been obtained. A possibility of the proton beam diagnostics using this raiation and the digital television method is illustrated. It is shown that thin aluminium fail doesn't perturb the proton beam and the conditions for using OTR for beam monitoring improve with proton energy. 15 refs.; 14 figs.; 1 tab

  6. Control of the beam-internal target interaction at the Nuclotron by means of light radiation

    International Nuclear Information System (INIS)

    The light radiation from various internal targets at the Nuclotron can be utilized for the operative control and time optimization of the interaction intensity of the beam. The examples presented in the paper illustrate the information about space characteristics of the circulating beam during one cycle of the accelerator run at the stages of injection, acceleration and during the physical experiments. (author)

  7. Coherent undulator radiation of electron beam, microbunched for the FEL power outcoupling

    Energy Technology Data Exchange (ETDEWEB)

    Kulipanov, G.N.; Sokolov, A.S.; Vinokurov, N.A. [Budker Institute of Nuclear Physics, Novosibirsk (Russian Federation)

    1995-12-31

    The spectral intensity of the coherent undulator radiation of electron beam, preliminarily microbunched by the FEL oscillator for the FEL power outcoupling, is approximately calculated by simple analytic considerations, taking into account the transverse emittances and the energy spread of the microbunched electron beams.

  8. Microdosimetric measurements of radiation quality variations in homogeneous phantoms irradiated by fast neutron beams

    International Nuclear Information System (INIS)

    The Dual Radiation Action Theory of Kellerer and Rossi (DRA), along with presently available microdosimetric techniques, is applied to the detrmination of radiation quality variation within tissue equivalent phantoms irradiated by collimated fast neutron beams. The neutron beams investigated were produced by the bombardment of 22.5 and 16 MeV d+ on beryllium and by the T(d,n)4He reaction (15-MeV neutrons). Microdosimetric spectra were obtained at points of varying depth and lateral distance from the central axis within a tissue equivalent phantom, including points within the penumbra. From the microdosimetric spectra the parameter RQ, a first approximation to RBE derived from DRA theory, is calculated for each point. All RQ values are calculated for the same level of effect. For these three different beams the results show that the RQ values for the total radiation spectrum of neutron and gamma radiation remain fairly constant with depth and with lateral distance from the beam axis at 2 and 10 cm depths. The largest central axis variation in RQ is 8% for the d(16)+Be beam. The largest variation between a penumbra and an on-axis RQ value is 4% at 2 cm depth in the d(22.5)+Be beam. The results for the d(22.5)+Be beam disagree with previously reported radiobiological results while the 15 MeV beam results are in good agreement

  9. Microdosimetric measurements of radiation quality variations in homogeneous phantoms irradiated by fast neutron beams

    International Nuclear Information System (INIS)

    The Dual Radiation Action Theory of Kellerer and Rossi (DRA), along with presently available microdosimetric techniques, is applied to the determination of radiation quality variation within tissue equivalent phantoms irradiated by collimated fast neutron beams. The neutron beams investigated were produced by the bombardment of 22.5 and 16 MeV d + on beryllium and by the T(d,n)4He reaction (15-MeV neutrons). Microdosimetric spectra were obtained at points of varying depth and lateral distance from the central axis within a tissue equivalent phantom, including points within the penumbra. From the microdosimetric spectra the parameter RQ, a first approximation to RBE derived from DRA theory, is calculated for each point. All RQ values are calculated for the same level of effect. For these three different beams the results show that the RQ values for the total radiation spectrum of neutron and gamma radiation remain fairly constant with depth and with lateral distance from the beam axis at 2 and 10 cm depths. The largest central axis variation in RQ is 8% for the d(16) + Be beam. The largest variation between a penumbra and an on-axis RQ value is 4% at 2 cm depth in the d(22.5) + Be beam. The results for the d (22.5) + Be beam disagree with previously reported radiological results while the 15 McV beam results are in good agreement

  10. Characterization and application of two extrapolation chambers in standard X radiation beams

    International Nuclear Information System (INIS)

    The extrapolation chambers are ionization chambers with variable volume, and they are mainly utilized as beta radiation detectors. In this work two extrapolation chambers were characterized, a commercial PTW extrapolation chamber and another extrapolation chamber developed at the Calibration Laboratory of IPEN, for application as reference systems in mammography, conventional diagnostic radiology and radiotherapy beams. The results obtained from the characterization tests of the chamber response: leakage current, short- and medium terms stability, determination of the saturation currents and the ion collection efficiencies, angular and energy dependence, show that these extrapolation chambers may be utilized for low-energy X radiation beam dosimetry. The transmission factors in tissue and the calibration factors were also determined for all cited radiation qualities. Finally, a procedure was established for calibration of radiation detectors in standard X radiation beams, using the extrapolation chambers. (author)

  11. The impact of MLC transmitted radiation on EPID dosimetry for dynamic MLC beams

    International Nuclear Information System (INIS)

    The purpose of this study was to experimentally quantify the change in response of an amorphous silicon (a-Si) electronic portal imaging device (EPID) to dynamic multileaf collimator (dMLC) beams with varying MLC-transmitted dose components and incorporate the response into a commercial treatment planning system (TPS) EPID prediction model. A combination of uniform intensity dMLC beams and static beams were designed to quantify the effect of MLC transmission on EPID response at the central axis of 10x10 cm2 beams, at off-axis positions using wide dMLC beam profiles, and at different field sizes. The EPID response to MLC transmitted radiation was 0.79±0.02 of the response to open beam radiation at the central axis of a 10x10 cm2 field. The EPID response to MLC transmitted radiation was further reduced relative to the open beam response with off-axis distance. The EPID response was more sensitive to field size changes for MLC transmitted radiation compared to open beam radiation by a factor of up to 1.17 at large field sizes. The results were used to create EPID response correction factors as a function of the fraction of MLC transmitted radiation, off-axis distance, and field size. Software was developed to apply the correction factors to each pixel in the TPS predicted EPID image. The corrected images agreed more closely with the measured EPID images in areas of intensity modulated fields with a large fraction of MLC transmission and, as a result the accuracy of portal dosimetry with a-Si EPIDs can be improved. Further investigation into the detector response function and the radiation source model are required to achieve improvements in accuracy for the general case

  12. Radiation pressure cross section exerted on homogenous dielectric spherical particle by zeroth order Mathieu beams

    Science.gov (United States)

    Chafiq, A.; Belafhal, A.

    2016-08-01

    In this paper, we present a full calculation of radiation pressure cross section and optical forces exerted by linearly polarized zeroth order Mathieu beams on homogenous dielectric spherical particle in the framework of generalized Lorenz-Mie theory (GLMT). In this theory, the scattered fields are dependent upon the Mie scattering coefficients and the beam shape coefficients. So a new optical property such as force and torque appears by changing the beam profile and the nature of particle. In this way, this work is devoted to the analysis of both transverse and longitudinal optical forces exerted on a simple dielectric spherical particle by zeroth order Mathieu beams and zeroth order Bessel (which is a particular case of the first beam). Thus, through numerical simulations, we show that zeroth order Mathieu beams can't trap this particle but Bessel beam presents some dimensional stable equilibrium points.

  13. Summary report of working group 5: Beam and radiation generation, monitoring, and control

    CERN Document Server

    Church, Mike; 10.1063/1.3520295

    2012-01-01

    This paper summarizes the activities and presentations of Working Group 5 of the Advanced Accelerator Concepts Workshop held at Annapolis, Maryland in June 2010. Working Group 5 touched on a broad range of topics in the fields of beam and radiation generation and their monitoring and control. These topics were not comprehensively covered in this Workshop, but rather the Working Group concentrated on specific new developments and recent investigations. The Working Group divided its sessions into four broad categories: cathodes and electron guns, radiation generation, beam diagnostics, and beam control and dynamics. This summary is divided into the same structure.

  14. A Monitor and Control System for the Synchrotron Radiation Beam Lines at DAΦNE

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Three synchrotron radiation beam lines have been built on DAΦNE,the Frascati electron-positron accelerator.It is Possible to monitor and control all the elements on the beam lines using a modular network distributed I/O system by National Instrunments (FieldPoint) with Bridge VIEW/Lab VIEW programs,Two of these beam lines have radiation safety problems solved by two independent and redundant systems,using mechanical switches ,and S7-200 PLC's by Siemens.In this article our solution will be described in details.

  15. Summary report of working group 5: Beam and radiation generation, monitoring, and control

    International Nuclear Information System (INIS)

    This paper summarizes the activities and presentations of Working Group 5 of the Advanced Accelerator Concepts Workshop held at Annapolis, Maryland in June 2010. Working Group 5 touched on a broad range of topics in the fields of beam and radiation generation and their monitoring and control. These topics were not comprehensively covered in this Workshop, but rather the Working Group concentrated on specific new developments and recent investigations. The Working Group divided its sessions into four broad categories: cathodes and electron guns, radiation generation, beam diagnostics, and beam control and dynamics. This summary is divided into the same structure.

  16. Summary Report of Working Group 5: Beam and Radiation Generation, Monitoring, and Control

    International Nuclear Information System (INIS)

    This paper summarizes the activities and presentations of Working Group 5 of the Advanced Accelerator Concepts Workshop held at Annapolis, Maryland in June 2010. Working Group 5 touched on a broad range of topics in the fields of beam and radiation generation and their monitoring and control. These topics were not comprehensively covered in this Workshop, but rather the Working Group concentrated on specific new developments and recent investigations. The Working Group divided its sessions into four broad categories: cathodes and electron guns, radiation generation, beam diagnostics, and beam control and dynamics. This summary is divided into the same structure.

  17. 21 CFR 892.5710 - Radiation therapy beam-shaping block.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Radiation therapy beam-shaping block. 892.5710 Section 892.5710 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Therapeutic Devices § 892.5710 Radiation therapy...

  18. Coherent and Tunable Terahertz Radiation from Graphene Surface Plasmon Polarirons Excited by Cyclotron Electron Beam

    Science.gov (United States)

    Zhao, Tao; Gong, Sen; Hu, Min; Zhong, Renbin; Liu, Diwei; Chen, Xiaoxing; Zhang, Ping; Wang, Xinran; Zhang, Chao; Wu, Peiheng; Liu, Shenggang

    2015-11-01

    Terahertz (THz) radiation can revolutionize modern science and technology. To this date, it remains big challenges to develop intense, coherent and tunable THz radiation sources that can cover the whole THz frequency region either by means of only electronics (both vacuum electronics and semiconductor electronics) or of only photonics (lasers, for example, quantum cascade laser). Here we present a mechanism which can overcome these difficulties in THz radiation generation. Due to the natural periodicity of 2π of both the circular cylindrical graphene structure and cyclotron electron beam (CEB), the surface plasmon polaritions (SPPs) dispersion can cross the light line of dielectric, making transformation of SPPs into radiation immediately possible. The dual natural periodicity also brings significant excellences to the excitation and the transformation. The fundamental and hybrid SPPs modes can be excited and transformed into radiation. The excited SPPs propagate along the cyclotron trajectory together with the beam and gain energy from the beam continuously. The radiation density is enhanced over 300 times, up to 105 W/cm2. The radiation frequency can be widely tuned by adjusting the beam energy or chemical potential. This mechanism opens a way for developing desired THz radiation sources to cover the whole THz frequency regime.

  19. Absolute and secondary dosimetry at the cyclotron ion beam radiation experiments

    International Nuclear Information System (INIS)

    One of the characteristic features of ion beam radiation experiments is that the absolute methods of dosimetry are more convenient than secondary ones. In this paper the absolute method used in the course of the radiation experiments performed on the U-400 Dubna cyclotron is presented in detail. Some remarks dealing with the secondary methods are also given. (author)

  20. Off-axial acoustic radiation force of pressor and tractor Bessel beams on a sphere

    CERN Document Server

    Silva, Glauber T; Lobo, Tiago P; Mitri, Farid G

    2012-01-01

    Acoustic Bessel beams are known to produce an axial radiation force on a sphere centered on the beam axis (on-axial configuration) that exhibits both "pressor" and "tractor" behaviors. The pressor and the tractor forces are oriented along the beam's direction of propagation and opposite to it, respectively. The behavior of the acoustic radiation force generated by Bessel beams when the sphere lies outside the beam's axis (off-axial configuration) is unknown. Using the 3D radiation force formulas given in terms of the partial wave expansion coefficients for the incident and scattered waves, both axial and transverse components of the force exerted on a silicone-oil sphere are obtained for a zero- and a first-order Bessel vortex beam. As the sphere departs from the beam's axis, the tractor force becomes weaker. Moreover, the behavior of the transverse radiation force field may vary with the sphere's size factor $ka$ (where $k$ is the wavenumber and $a$ is the sphere radius). Both stable and unstable equilibrium...

  1. Feasibility of optical diffraction radiation for a non-invasive low-emittance beam diagnostics

    CERN Document Server

    Urakawa, J; Kubo, K; Kuroda, S; Terunuma, N; Kuriki, M; Okugi, T; Naito, T; Araki, S; Potylitsin, A P; Naumenko, G A; Karataev, P; Potylitsyna, N A; Vnukov, I; Hirose, T; Hamatsu, R; Muto, T; Ikezawa, M; Shibata, Y

    2001-01-01

    A 'proof-of-principle' experiment on the optical diffraction radiation (ODR) as a single-pulse beam profile monitor is planned using an electron beam extracted from the KEK-ATF damping ring. The main goals of this experiment are the following: (i) To measure the yield and the angular distributions of the optical diffraction radiation from a large-size target at different wavelengths, impact parameters and beam characteristics for a comparison with analogous characteristics of optical transition radiation from a foil with identical optical parameters and for a verification of the model assumption (perfectly conducting semi-infinite target). (ii) To investigate the ODR angular distributions from a tilted target with a slit for observing the interference effects. (iii) To compare the results obtained by simulations based on classical approaches, taking into account the optical characteristics of the equipment and the beam parameters. (iv) To estimate the prospects of using ODR as a new non-invasive tool for ultr...

  2. Measured Radiation and Background Levels During Transmission of Megawatt Electron Beams Through Millimeter Apertures

    International Nuclear Information System (INIS)

    We report measurements of photon and neutron radiation levels observed while transmitting a 0.43 MW electron beam through millimeter-sized apertures and during beam-off, but accelerating gradient RF-on, operation. These measurements were conducted at the Free-Electron Laser (FEL) facility of the Jefferson National Accelerator Laboratory (JLab) using a 100 MeV electron beam from an energy-recovery linear accelerator. The beam was directed successively through 6 mm, 4 mm, and 2 mm diameter apertures of length 127 mm in aluminum at a maximum current of 4.3 mA (430 kW beam power). This study was conducted to characterize radiation levels for experiments that need to operate in this environment, such as the proposed DarkLight Experiment. We find that sustained transmission of a 430 kW continuous-wave (CW) beam through a 2 mm aperture is feasible with manageable beam-related backgrounds. We also find that during beam-off, RF-on operation, multipactoring inside the niobium cavities of the accelerator cryomodules is the primary source of ambient radiation when the machine is tuned for 130 MeV operation

  3. Measured radiation and background levels during transmission of megawatt electron beams through millimeter apertures

    International Nuclear Information System (INIS)

    We report measurements of photon and neutron radiation levels observed while transmitting a 0.43 MW electron beam through millimeter-sized apertures and during beam-off, but accelerating gradient RF-on, operation. These measurements were conducted at the Free-Electron Laser (FEL) facility of the Jefferson National Accelerator Laboratory (JLab) using a 100 mev electron beam from an energy-recovery linear accelerator. The beam was directed successively through 6 mm, 4 mm, and 2 mm diameter apertures of length 127 mm in aluminum at a maximum current of 4.3 mA (430 kW beam power). This study was conducted to characterize radiation levels for experiments that need to operate in this environment, such as the proposed DarkLight Experiment. We find that sustained transmission of a 430 kW continuous-wave (CW) beam through a 2 mm aperture is feasible with manageable beam-related backgrounds. We also find that during beam-off, RF-on operation, multipactoring inside the niobium cavities of the accelerator cryomodules is the primary source of ambient radiation when the machine is tuned for 130 mev operation

  4. Measured Radiation and Background Levels During Transmission of Megawatt Electron Beams Through Millimeter Apertures

    Energy Technology Data Exchange (ETDEWEB)

    Alarcon, Ricardo [Arizona State University, Glendale, AZ (United States); Balascuta, S. [Arizona State University, Glendale, AZ (United States); Benson, Stephen V. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Bertozzi, William [Massachusetts Institute of Technology, Cambridge, MA (United States); Boyce, James R. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Cowan, Ray [Massachusetts Institute of Technology, Cambridge, MA (United States); Douglas, David R. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Evtushenko, Pavel [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Fisher, P. [Massachusetts Institute of Technology, Cambridge, MA (United States); Ihloff, Ernest E. [Hampton University, Hampton, VA (United States); Kalantarians, Narbe [Hampton University, Hampton, VA (United States); Kelleher, Aidan Michael [Massachusetts Institute of Technology, Cambridge, MA (United States); Krossler, W. J. [William and Mary College, Williamsburg, VA (United States); Legg, Robert A. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Long, Elena [University of New Hampshire, Durham, NH (United States); Milner, Richard [Massachusetts Institute of Technology, Cambridge, MA (United States); Neil, George R. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Ou, Longwu [Massachusetts Institute of Technology, Cambridge, MA (United States); Schmookler, Barack Abraham [Massachusetts Institute of Technology, Cambridge, MA (United States); Tennant, Christopher D. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Tschalar, C. [Massachusetts Institute of Technology, Cambridge, MA (United States); Williams, Gwyn P. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Zhang, Shukui [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)

    2013-11-01

    We report measurements of photon and neutron radiation levels observed while transmitting a 0.43 MW electron beam through millimeter-sized apertures and during beam-off, but accelerating gradient RF-on, operation. These measurements were conducted at the Free-Electron Laser (FEL) facility of the Jefferson National Accelerator Laboratory (JLab) using a 100 MeV electron beam from an energy-recovery linear accelerator. The beam was directed successively through 6 mm, 4 mm, and 2 mm diameter apertures of length 127 mm in aluminum at a maximum current of 4.3 mA (430 kW beam power). This study was conducted to characterize radiation levels for experiments that need to operate in this environment, such as the proposed DarkLight Experiment. We find that sustained transmission of a 430 kW continuous-wave (CW) beam through a 2 mm aperture is feasible with manageable beam-related backgrounds. We also find that during beam-off, RF-on operation, multipactoring inside the niobium cavities of the accelerator cryomodules is the primary source of ambient radiation when the machine is tuned for 130 MeV operation.

  5. Beam lifetime calculation in an electron storage ring for synchrotron radiation

    International Nuclear Information System (INIS)

    In an electron storage ring dedicated for synchrotron radiation, the beam lifetime should be of a few hours, so that the radiation is available to the users for sufficient time. The beam lifetime in an electron storage ring is the average of the finite lifetimes arising due to betatron and energy oscillations, Coulomb scattering and elastic and inelastic scattering of electrons due to residual gases present in the beam tube. A computer program has been written to study the variation of beam lifetime with various machine parameters such as lattice functions, rf voltage, tube aperture etc. The program has been developed to take input data from AGS computer program output. The lifetime of electron beam at lower energies has been studied for a weak focussing electron storage ring and is found to be governed mainly by Coulomb scattering. (author). 3 figs

  6. Optical transition radiation from a thin carbon foil: a beam profile monitor for the SLC

    International Nuclear Information System (INIS)

    This memo considers placement of an ultra thin carbon foil into the SLC beam. Transition radiation light would be emitted from the surface of the foil. The optical spot from the foil could be viewed with a microscope objective lens and registered with an image detector. Multiple scattering for the foil thicknesses necessary will not affect the beam emittance. Calculations show that a thin carbon foil can withstand the electron beam if the electron beam is larger than 10 μm in size. There are many possible radiation mechanisms from a foil - bremsstrahlung, black body temperature radiation, Cerenkov light, scintillation light, and transition radiation. Transition radiation is apparently dominant. It is proposed to use thin carbon foils, 75 to 150 A thick. Calculations indicate that 5 x 1010 beam electrons will radiate a useable number of optical photons. Specifically with 150 A foils the fractional yield of useful optical photons is 10-3 photons per incident electron 5 x 10+7 optical photons imaged upon an image plane. Spread these photons over a 32 x 32 pixel CCD and one has the readout system of a monitor

  7. Calculation of the dose to lymphocytes in external beam radiation therapy

    International Nuclear Information System (INIS)

    Lymphopenia is known to occur in patients undergoing external beam radiation therapy when the radiation fields encompass major blood vessels and lymphatic tissue. The dose received by the lymphocytes has up to now not been determined. We present here a general formalism for the calculation of the lymphocyte dose for a patient undergoing fractionated radiation therapy at any irradiation site. The calculation procedure is demonstrated for a typical case of pelvic irradiation

  8. Calculation of the dose to lymphocytes in external beam radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Ekstrand, K.E.; Dixon, R.L.; Plunkett, S.; Raben, M.

    1981-02-01

    Lymphopenia is known to occur in patients undergoing external beam radiation therapy when the radiation fields encompass major blood vessels and lymphatic tissue. The dose received by the lymphocytes has up to now not been determined. We present here a general formalism for the calculation of the lymphocyte dose for a patient undergoing fractionated radiation therapy at any irradiation site. The calculation procedure is demonstrated for a typical case of pelvic irradiation.

  9. Radiation losses in PLT during neutral beam and ICRF heating experiments

    International Nuclear Information System (INIS)

    Radiation and charge exchange losses in the PLT tokamak are compared for discharges with ohmic heating only (OH), and with additional heating by neutral beams (NB) or RF in the ion cyclotron frequency range (ICRF). Spectroscopic, bolometric and soft x-ray diagnostics were used. The effects of discharge cleaning, vacuum wall gettering, and rate of gas inlet on radiation losses from OH plasmas and the correlation between radiation from plasma core and edge temperatures are discussed

  10. Evaluation of ozone concentration for a white beam line hutch at Indus-2 synchrotron radiation source

    International Nuclear Information System (INIS)

    In the synchrotron radiation source Indus-2, 26 synchrotron radiation beam lines are planned, out of which 7 beam lines are operational and several are in installation stage. For carrying out experiments, SR beam is brought out to air through the beam lines (which are housed in shielded hutches). Due to the interaction of SR with air, ozone is produced, which is a noxious gas and is hazardous, if inhaled in excess. The production of ozone is high in white beam lines in comparison with pink and monochromatic beam lines. In the present paper ozone generation for a white beam line of Indus-2 is estimated. The ozone production rate, saturation concentration, ventilation rate and delay time are also estimated. The saturation concentration of ozone for the white beam line (energy dispersive X-ray diffraction beam line) BL-11 was found to be 0.965 ppm for 100 cm interaction path length and 51.45 m3 hutch volume without any ventilation. The paper presents the details of the calculation and the results. (author)

  11. Effect of electron beam radiations on anxiety in experimental animal models

    International Nuclear Information System (INIS)

    Exposures to ionizing radiation have been an inevitable part of the environment. This type of radiation can disrupt atoms, creating positive and negative charged particles, and cause biological harm. Ionizing radiation includes X-rays, gamma rays, alpha particles, beta particles and neutrons. They have the potential to cause both beneficial and harmful effects. There are concerns about these radiations as they are widely used in hospitals for treatment and diagnosis of various diseases. The present work was designed to test the effect of whole body electron beam radiation on anxiety in mice using the Elevated plus maze and Light dark arena, the commonly used models for assessing anxiety in rodents. Mice were irradiated with three different doses (2 Gy, 4 Gy and 6 Gy) of electron beam radiations. Statistical analysis revealed that whole body irradiation of the moderate dose range (2-6 Gy) of electron beam leads to a significant (p<0.001) anxiogenic activity in irradiated mice. Electron beam induced anxiety can be due to radiation induced reactive oxygen species in brain. (author)

  12. Beam Size Measurement by Optical Diffraction Radiation and Laser System for Compton Polarimeter

    International Nuclear Information System (INIS)

    Beam diagnostics is an essential constituent of any accelerator, so that it is named as 'organs of sense' or 'eyes of the accelerator.' Beam diagnostics is a rich field. A great variety of physical effects or physical principles are made use of in this field. Some devices are based on electro-magnetic influence by moving charges, such as faraday cups, beam transformers, pick-ups; Some are related to Coulomb interaction of charged particles with matter, such as scintillators, viewing screens, ionization chambers; Nuclear or elementary particle physics interactions happen in some other devices, like beam loss monitors, polarimeters, luminosity monitors; Some measure photons emitted by moving charges, such as transition radiation, synchrotron radiation monitors and diffraction radiation-which is the topic of the first part of this thesis; Also, some make use of interaction of particles with photons, such as laser wire and Compton polarimeters-which is the second part of my thesis. Diagnostics let us perceive what properties a beam has and how it behaves in a machine, give us guideline for commissioning, controlling the machine and indispensable parameters vital to physics experiments. In the next two decades, the research highlight will be colliders (TESLA, CLIC, JLC) and fourth-generation light sources (TESLA FEL, LCLS, Spring 8 FEL) based on linear accelerator. These machines require a new generation of accelerator with smaller beam, better stability and greater efficiency. Compared with those existing linear accelerators, the performance of next generation linear accelerator will be doubled in all aspects, such as 10 times smaller horizontal beam size, more than 10 times smaller vertical beam size and a few or more times higher peak power. Furthermore, some special positions in the accelerator have even more stringent requirements, such as the interaction point of colliders and wigglor of free electron lasers. Higher performance of these accelerators increases the

  13. Beam Size Measurement by Optical Diffraction Radiation and Laser System for Compton Polarimeter

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Chuyu [Peking Univ., Beijing (China)

    2012-12-31

    Beam diagnostics is an essential constituent of any accelerator, so that it is named as "organs of sense" or "eyes of the accelerator." Beam diagnostics is a rich field. A great variety of physical effects or physical principles are made use of in this field. Some devices are based on electro-magnetic influence by moving charges, such as faraday cups, beam transformers, pick-ups; Some are related to Coulomb interaction of charged particles with matter, such as scintillators, viewing screens, ionization chambers; Nuclear or elementary particle physics interactions happen in some other devices, like beam loss monitors, polarimeters, luminosity monitors; Some measure photons emitted by moving charges, such as transition radiation, synchrotron radiation monitors and diffraction radiation-which is the topic of the first part of this thesis; Also, some make use of interaction of particles with photons, such as laser wire and Compton polarimeters-which is the second part of my thesis. Diagnostics let us perceive what properties a beam has and how it behaves in a machine, give us guideline for commissioning, controlling the machine and indispensable parameters vital to physics experiments. In the next two decades, the research highlight will be colliders (TESLA, CLIC, JLC) and fourth-generation light sources (TESLA FEL, LCLS, Spring 8 FEL) based on linear accelerator. These machines require a new generation of accelerator with smaller beam, better stability and greater efficiency. Compared with those existing linear accelerators, the performance of next generation linear accelerator will be doubled in all aspects, such as 10 times smaller horizontal beam size, more than 10 times smaller vertical beam size and a few or more times higher peak power. Furthermore, some special positions in the accelerator have even more stringent requirements, such as the interaction point of colliders and wigglor of free electron lasers. Higher performance of these accelerators increases the

  14. Efficacy of electron beams in radiation disinfestation of jute bags

    International Nuclear Information System (INIS)

    An irradiator generating electron radiation may be employed for radiation disinfestation of jute bags infested with larvae and adults of the confused flour beetle, Tribolium confusum DuV., if they are created as separate units or small batches, containing up to 40 bags, and are irradiated with a 2 kGy dose. (author)

  15. Radiation shielding for the ITER neutral beam test facility

    International Nuclear Information System (INIS)

    The NB system for the International Thermonuclear Experimental Reactor (ITER) consists of two heating and current drive (H and CD) NB injectors and a diagnostic neutral beam (DNB) injector. The NB accelerates negative deuterium ions with maximum energy of 1 MeV and maximum beam current of 40 A. The ITER (H and CD) NB will be tested in the Neutral Beam Test Facility (NBTF) that will be located in Italy, near Padua. The performance test will be based on different operation phases starting with low energy hydrogen beam. In the initial testing phase for many months the machine will operate with hydrogen only and with deuteron at a reduced intensity suggesting the possibility of hosting the device in a light shielding room/area. In the paper the study performed to evaluate the minimum shielding needed in connection with the different operation phases is shown. The source terms were calculated starting from neutron source characterisation and then assessing article transport in the ITER NB structure with a mathematical model of the components geometry that was implemented into MCNP computer code. The neutron source definition was outlined considering both D-D and D-T neutron production. Shielding was assessed for hydrogen operation only and for 20, 60, 100 and 1000 kV (full energy) deuteron acceleration, accounting for the associated beam current intensity. Related results are presented and discussed in the paper. (author)

  16. INFLUENCE OF INCUBATION TIME, GAMMA RAYS AND ELECTRON BEAM ON RADIATION RESISTANCE OF SOME SELECTED PATHOGENS

    International Nuclear Information System (INIS)

    The effect of different growth phases on the radiation resistance, antibiotic susceptibility and pathogenicity of certain selected pathogens (Escherichia coli, Candida albicans and Staphylococcus aureus) was studied in mice. The obtained results showed that Escherichia coli was slightly more resistant to gamma radiation in 18 h than 24 h or 48 h but it was relatively more resistant to electron beam in 24 h and 48 h than 18 h. Candida albicans showed radiation resistance nearly the same in all incubation times in the case of gamma radiation while for electron beam, its radiation resistance was slightly more in 24 h and 48 h than in 18 h. On the other hand, Staphylococcus aureus recorded much more resistance to gamma radiation in the 48 h than in 24 h or 18 h whereas in the case of electron beam, it was slightly more resistant in 18 h than in 24 h and 48 h.The antibiotic susceptibility of Escherichia coli reported that the exposure to gamma radiation at 3 kGy and electron beam at 6 kGy increase the susceptibility to the nalidixic acid and nitrofurantoin. When Candida albicans was exposed to 3 kGy gamma radiation and 6 kGy electron beam, the same sensitivity to nystatin was observed in comparison with the unexposed one while the sensitivity of Staphylococcus aureus to some antibiotics (amoxicillin, nitrofurantoin and tetracycline) was decreased after exposure to gamma radiation at 0.75 and 2 kGy and electron beam at 6 kGy, but for other antibiotics (trimethoprim/ sulfamethoxazole), the sensitivity was increased at 6 kGy electron beam.The lethality percent recorded after the oral ingestion of the mice with the unexposed Escherichia coli and Candida albicans were 25% and 100%, respectively, and for 6 kGy exposure to electron beam was 0% . The cotaneous disease and abscesses caused by the intradermal injection of the mice with unexposed Staphylococcus aureus was 75% and for 6 kGy exposure to electron beam was 25%.

  17. A surrogate-based metaheuristic global search method for beam angle selection in radiation treatment planning

    International Nuclear Information System (INIS)

    An important element of radiation treatment planning for cancer therapy is the selection of beam angles (out of all possible coplanar and non-coplanar angles in relation to the patient) in order to maximize the delivery of radiation to the tumor site and minimize radiation damage to nearby organs-at-risk. This category of combinatorial optimization problem is particularly difficult because direct evaluation of the quality of treatment corresponding to any proposed selection of beams requires the solution of a large-scale dose optimization problem involving many thousands of variables that represent doses delivered to volume elements (voxels) in the patient. However, if the quality of angle sets can be accurately estimated without expensive computation, a large number of angle sets can be considered, increasing the likelihood of identifying a very high quality set. Using a computationally efficient surrogate beam set evaluation procedure based on single-beam data extracted from plans employing equally-spaced beams (eplans), we have developed a global search metaheuristic process based on the nested partitions framework for this combinatorial optimization problem. The surrogate scoring mechanism allows us to assess thousands of beam set samples within a clinically acceptable time frame. Tests on difficult clinical cases demonstrate that the beam sets obtained via our method are of superior quality. (paper)

  18. Fracture analysis of HFIR beam tube caused by radiation embrittlement

    Energy Technology Data Exchange (ETDEWEB)

    Chang, S.J. [Oak Ridge National Lab., TN (United States). Research Reactors Div.

    1994-12-31

    With an attempt to estimate the neutron beam tube embrittlement condition for the Oak Ridge High Flux Isotope Reactor (HFIR), fracture mechanics calculations are carried out in this paper. The analysis provides some numerical result on how the tube has been structurally weakened. In this calculation, a lateral impact force is assumed. Numerical result is obtained on how much the critical crack size should be reduced if the beam tube has been subjected to an extended period of irradiation. It is also calculated that buckling strength of the tube is increased, not decreased, with irradiation.

  19. TH-C-17A-09: Direct Visualization and Monitoring of Medical Radiation Beams in Air

    Energy Technology Data Exchange (ETDEWEB)

    Fahimian, B; Ceballos, A; Turkcan, S; Kapp, D; Pratx, G [Stanford University, Stanford, CA (United States)

    2014-06-15

    Purpose: Radiation therapy errors are rare but potentially catastrophic. Recent fatal incidents could have been avoided by utilizing real-time methods of monitoring delivery of radiation during treatment. However, few existing methods are practical enough to be used routinely. The study presents the first experimental demonstration of a novel non-perturbing method of monitoring radiation therapy through the phenomena of air scintillation. Methods: Monitoring of radiation delivery was devised by leveraging the phenomena of nitrogen excitation in air by ionizing radiation. The excitation induced weak luminescence in the 300–400 nm range, a process called air scintillation. An electron-multiplication charge-coupled device camera (f/0.95 lens; 440 nm shortpass) was set-up in a clinical treatment vault and was used to capture air scintillation images of kilovoltage and megavoltage beams. Monte Carlo simulations were performed to determine the correlation of radiation dose to air scintillation. Results: Megavoltage beams from a Varian Clinac 21EX and kilovoltage beams from an orthovoltage unit (50 kVp, 30 mA) were visualized with a relatively short exposure time (10 s). Cherenkov luminescence produced in a plastic transparent phantom did not interfere with detection of air scintillation. The image intensity displayed an inverse intensity falloff (r{sup 2} = 0.89) along the central axis and was proportional to dose rate (r{sup 2} = 0.9998). As beam energy increased, the divergence of the imaged beam decreased. Last, air scintillation was visualized during a simulated total skin irradiation electron treatment. Conclusion: Air scintillation can be clinically detected to monitor a radiation beam in an inexpensive and non-perturbing manner. This new method is advantageous in monitoring for gross delivery and uniquely capable of wide area in a single acquisition, such as the case for online verification of total body / skin / lymphoid irradiation treatments.

  20. Acoustical radiation torque and force for spheres and Bessel beam extinction efficiency

    Science.gov (United States)

    Marston, Philip L.; Zhang, Likun

    2014-11-01

    The scattering of optical and acoustical beams is relevant to the levitation and manipulation of drops. Here we examine theoretical developments in the acoustical case. We previously showed how the optical theorem for extinction can be extended to invariant beams. The example of a sphere in a Bessel beam facilitates the direct comparison with a circular disc computed using Babinet's principle and the Kirchhoff approximation. In related work, by considering traveling or standing wave first-order vortex beams we previously showed that the radiation torque is the ratio of the absorbed power and the radian acoustic frequency. By modifying the scattering to account for the viscosity of the surrounding fluid in the analysis of the absorbed power, approximations for radiation torque and force are obtained at long wavelengths in special cases and these can be compared with results published elsewhere.

  1. Resonant terahertz radiation from warm collisional inhomogeneous plasma irradiated by two Gaussian laser beams

    Science.gov (United States)

    Niknam, A. R.; Banjafar, M. R.; Jahangiri, F.; Barzegar, S.; Massudi, R.

    2016-05-01

    Terahertz (THz) radiation generation by the interaction of two co-propagating high intensity laser beams with a warm collisional inhomogeneous plasma is analytically investigated. By presenting the dielectric permittivity of plasma and taking into account the ponderomotive force, the nonlinear current at THz frequency is obtained. A secondary resonant enhancement of THz radiation is observed, in addition to that occurs at the plasma frequency, which can be tuned by plasma density and temperature. Moreover, we show that for each beat frequency, there exists an optimum temperature at which THz radiation is maximized. It is also shown that the power and efficiency of THz radiation decrease by increasing the collision frequency.

  2. Radiation tolerant programmable power supply for the LHC beam screen heaters

    International Nuclear Information System (INIS)

    For the next LHC run, it is required to install 200 W of heating capacity per LHC beam screen heater to regenerate the beam screen by desorption of gas trapped on its walls. In the LHC, there are 272 beam screen heaters and the associated electronics limit presently the heating capacity to 25 W. Those electronics are, for the most part, installed inside the LHC tunnel and exposed to its radiation environment. This paper describes the development of a new programmable power supply card that will be integrated into the existing LHC radiation tolerant electronic infrastructure used by the cryogenic system. Radiation tests were undertaken to qualify a power switch capable of coping with the 230 Vrms grid voltage and an analog signal multiplexer; these components are required respectively for satisfying the higher power requirements and for reducing the overall cost by using a single analog to digital converter to sample all the signals

  3. Radiation tolerant programmable power supply for the LHC beam screen heaters

    Science.gov (United States)

    Casas, J.; Trikoupis, N.

    2014-03-01

    For the next LHC run, it is required to install 200 W of heating capacity per LHC beam screen heater to regenerate the beam screen by desorption of gas trapped on its walls. In the LHC, there are 272 beam screen heaters and the associated electronics limit presently the heating capacity to 25 W. Those electronics are, for the most part, installed inside the LHC tunnel and exposed to its radiation environment. This paper describes the development of a new programmable power supply card that will be integrated into the existing LHC radiation tolerant electronic infrastructure used by the cryogenic system. Radiation tests were undertaken to qualify a power switch capable of coping with the 230 Vrms grid voltage and an analog signal multiplexer; these components are required respectively for satisfying the higher power requirements and for reducing the overall cost by using a single analog to digital converter to sample all the signals.

  4. Betatron radiation based diagnostics for plasma wakefield accelerated electron beams at the SPARC_LAB test facility

    Science.gov (United States)

    Shpakov, V.; Anania, M. P.; Biagioni, A.; Chiadroni, E.; Cianchi, A.; Curcio, A.; Dabagov, S.; Ferrario, M.; Filippi, F.; Marocchino, A.; Paroli, B.; Pompili, R.; Rossi, A. R.; Zigler, A.

    2016-09-01

    Recent progress with wake-field acceleration has shown a great potential in providing high gradient acceleration fields, while the quality of the beams remains relatively poor. Precise knowledge of the beam size at the exit from the plasma and matching conditions for the externally injected beams are the key for improvement of beam quality. Betatron radiation emitted by the beam during acceleration in the plasma is a powerful tool for the transverse beam size measurement, being also non-intercepting. In this work we report on the technical solutions chosen at SPARC_LAB for such diagnostics tool, along with expected parameters of betatron radiation.

  5. Seeing the invisible: Direct visualization of therapeutic radiation beams using air scintillation

    Energy Technology Data Exchange (ETDEWEB)

    Fahimian, Benjamin; Türkcan, Silvan; Kapp, Daniel S.; Pratx, Guillem, E-mail: pratx@stanford.edu [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 (United States); Ceballos, Andrew [Department of Electrical Engineering, Stanford University, Stanford, California 94305 (United States)

    2014-01-15

    Purpose: To assess whether air scintillation produced during standard radiation treatments can be visualized and used to monitor a beam in a nonperturbing manner. Methods: Air scintillation is caused by the excitation of nitrogen gas by ionizing radiation. This weak emission occurs predominantly in the 300–430 nm range. An electron-multiplication charge-coupled device camera, outfitted with an f/0.95 lens, was used to capture air scintillation produced by kilovoltage photon beams and megavoltage electron beams used in radiation therapy. The treatment rooms were prepared to block background light and a short-pass filter was utilized to block light above 440 nm. Results: Air scintillation from an orthovoltage unit (50 kVp, 30 mA) was visualized with a relatively short exposure time (10 s) and showed an inverse falloff (r{sup 2} = 0.89). Electron beams were also imaged. For a fixed exposure time (100 s), air scintillation was proportional to dose rate (r{sup 2} = 0.9998). As energy increased, the divergence of the electron beam decreased and the penumbra improved. By irradiating a transparent phantom, the authors also showed that Cherenkov luminescence did not interfere with the detection of air scintillation. In a final illustration of the capabilities of this new technique, the authors visualized air scintillation produced during a total skin irradiation treatment. Conclusions: Air scintillation can be measured to monitor a radiation beam in an inexpensive and nonperturbing manner. This physical phenomenon could be useful for dosimetry of therapeutic radiation beams or for online detection of gross errors during fractionated treatments.

  6. Beam-centric algorithm for pretreatment patient position correction in external beam radiation therapy

    International Nuclear Information System (INIS)

    Purpose: In current image guided pretreatment patient position adjustment methods, image registration is used to determine alignment parameters. Since most positioning hardware lacks the full six degrees of freedom (DOF), accuracy is compromised. The authors show that such compromises are often unnecessary when one models the planned treatment beams as part of the adjustment calculation process. The authors present a flexible algorithm for determining optimal realizable adjustments for both step-and-shoot and arc delivery methods. Methods: The beam shape model is based on the polygonal intersection of each beam segment with the plane in pretreatment image volume that passes through machine isocenter perpendicular to the central axis of the beam. Under a virtual six-DOF correction, ideal positions of these polygon vertices are computed. The proposed method determines the couch, gantry, and collimator adjustments that minimize the total mismatch of all vertices over all segments with respect to their ideal positions. Using this geometric error metric as a function of the number of available DOF, the user may select the most desirable correction regime. Results: For a simulated treatment plan consisting of three equally weighted coplanar fixed beams, the authors achieve a 7% residual geometric error (with respect to the ideal correction, considered 0% error) by applying gantry rotation as well as translation and isocentric rotation of the couch. For a clinical head-and-neck intensity modulated radiotherapy plan with seven beams and five segments per beam, the corresponding error is 6%. Correction involving only couch translation (typical clinical practice) leads to a much larger 18% mismatch. Clinically significant consequences of more accurate adjustment are apparent in the dose volume histograms of target and critical structures. Conclusions: The algorithm achieves improvements in delivery accuracy using standard delivery hardware without significantly increasing

  7. Automatic beam position control at Los Alamos Spallation Radiation Effects Facility (LASREF)

    International Nuclear Information System (INIS)

    Historically the Los Alamos Spallation Radiation Effects Facility (LASREF) has used manual methods to control the position of the 800 kW, 800 MeV proton beam on targets. New experiments, however, require more stringent position control more frequently than can be done manually for long periods of time. Data from an existing harp is used to automatically adjust steering magnets to maintain beam position to required tolerances

  8. Radiation Exposure of Patients by Cone Beam CT during Endobronchial Navigation - A Phantom Study

    OpenAIRE

    Hohenforst-Schmidt, Wolfgang; Banckwitz, Rosemarie; Zarogoulidis, Paul; Vogl, Thomas; Darwiche, Kaid; Goldberg, Eugene; Huang, Haidong; Simoff, Michael; Li, Qiang; Browning, Robert; Freitag, Lutz; Turner, J. Francis; Pivert, Patrick Le; Yarmus, Lonny; Zarogoulidis, Konstantinos

    2014-01-01

    Rationale: Cone Beam Computed Tomography imaging has become increasingly important in many fields of interventional therapies. Objective: Lung navigation study which is an uncommon soft tissue approach. Methods: As no effective organ radiation dose levels were available for this kind of Cone Beam Computed Tomography application we simulated in our DynaCT (Siemens AG, Forchheim, Germany) suite 2 measurements including 3D acquisition and again for 3D acquisition and 4 endobronchial navigation m...

  9. Image-guided small animal radiation research platform: calibration of treatment beam alignment

    International Nuclear Information System (INIS)

    Small animal research allows detailed study of biological processes, disease progression and response to therapy with the potential to provide a natural bridge to the clinical environment. The small animal radiation research platform (SARRP) is a portable system for precision irradiation with beam sizes down to approximately 0.5 mm and optimally planned radiation with on-board cone-beam CT (CBCT) guidance. This paper focuses on the geometric calibration of the system for high-precision irradiation. A novel technique for the calibration of the treatment beam is presented, which employs an x-ray camera whose precise positioning need not be known. Using the camera system we acquired a digitally reconstructed 3D 'star shot' for gantry calibration and then developed a technique to align each beam to a common isocenter with the robotic animal positioning stages. The calibration incorporates localization by cone-beam CT guidance. Uncorrected offsets of the beams with respect to the calibration origin ranged from 0.4 mm to 5.2 mm. With corrections, these alignment errors can be reduced to the sub-millimeter range. The calibration technique was used to deliver a stereotactic-like arc treatment to a phantom constructed with EBT Gafchromic films. All beams were shown to intersect at a common isocenter with a measured beam (FWHM) of approximately 1.07 mm using the 0.5 mm collimated beam. The desired positioning accuracy of the SARRP is 0.25 mm and the results indicate an accuracy of 0.2 mm. To fully realize the radiation localization capabilities of the SARRP, precise geometric calibration is required, as with any such system. The x-ray camera-based technique presented here provides a straightforward and semi-automatic method for system calibration.

  10. Radiation protection commissioning of neutron beam instruments at the OPAL research reactor

    International Nuclear Information System (INIS)

    The neutron beam facilities at the 20 MW OPAL Research Reactor were commissioned in 2007 and 2008. The initial suite of eight neutron beam instruments on two thermal neutron guides, two cold neutron guides and one thermal beam port located at the reactor face, together with their associated shielding were progressively installed and commissioned according to their individual project plans. Radiation surveys were systematically conducted as reactor power was raised in a step-wise manner to 20 MW in order to validate instrument shielding design and performance. The performance of each neutron guide was assessed by neutron energy spectrum and flux measurements. The activation of beam line components, decay times assessments and access procedures for Bragg Institute beam instrument scientists were established. The multiple configurations for each instrument and the influence of operating more than one instrument or beamline simultaneously were also tested. Areas of interest were the shielding around the secondary shutters, guide shield and bunker shield interfaces and monochromator doors. The shielding performance, safety interlock checks, improvements, radiation exposures and related radiation protection challenges are discussed. This paper discusses the health physics experience of commissioning the OPAL Research Reactor neutron beam facilities and describes health physics results, actions taken and lessons learned during commissioning. (author)

  11. Radiation protection commissioning of neutron beam instruments at the OPAL Research Reactor

    International Nuclear Information System (INIS)

    The neutron beam facilities at the 20 MW OPAL Research Reactor were commissioned in 2007 and 2008. The initial suite of eight neutron beam instruments on two thermal neutron guides, two cold neutron guides and one thermal beam port located at the reactor face, together with their associated shielding were progressively installed and commissioned according to their individual project plans. Radiation surveys were systematically conducted as reactor power was raised in a step-wise manner to 20MW in order to validate instrument shielding design and performance. The performance of each neutron guide was assessed by neutron energy spectrum and flux measurements. The activation of beam line components, decay times assessments and access procedures for Bragg Institute beam instrument scientists were established. The multiple configurations for each instrument and the influence of operating more than one instrument or beamline simultaneously were also tested. Areas of interest were the shielding around the secondary shutters, guide shield and bunker shield interfaces and monochromator doors. The shielding performance, safety interlock checks, improvements, radiation exposures and related radiation protection challenges are discussed. This paper discusses the health physics experience of commissioning the OPAL Research Reactor neutron beam facilities and describes health physics results, actions taken and lessons learned during commissioning. (author)

  12. Beam standardization of X radiation in computed tomography

    International Nuclear Information System (INIS)

    The ionization chamber used in dosimetric procedures in computed tomography beams (CT), is a cylindrical chamber, unsealed, with the sensitive length between 10 and 15 cm, named pencil ionization chamber. Because the doses involved in CT procedures are higher s than those in the procedures in radiology, it is very important to ensure the appropriate calibration of pencil ionization chambers and thus the accuracy of Dosimetric procedures. Recently, only the Calibration Laboratory, from Institute de Pesquisas Energeticas e Nucleares, had standards fields of conventional radiodiagnostic, but not arrived to include the energy range used in CT. In this work, will be shown the results obtained in standard field of radiodiagnostic - all qualities of radiodiagnostic of series RQR (direct beam) and RQA (attenuated beam) described in IEC 61267 norm - in an industrial X-ray equipment of the Calibration Laboratory. The recommended qualities for the calibration of TC chambers are the qualities RQA9 and RQR9. The other qualities will be used for calibration of other radiodiagnostic dosimeters and also for a larger study of the energy dependence of the pencil ionization chambers

  13. Economical aspects of radiation sterilization with electron beam

    International Nuclear Information System (INIS)

    Radiation sterilization has been introduced in Poland in the early seventies. Since then continuous progress is observed in quantity of sterilized products. The commercial irradiation facility was built in 1993 to fulfill growing demands for radiation service. The real costs of running this plant were shown. The share of the cost of investment and the cost of maintenance and spare parts in accelerator exploitation, as well as the cost of one hour accelerator exploitation against time of one year accelerator exploitation were taken into account

  14. Radiative and collisional processes of highly charged heavy ions studied with electron beam ion traps

    International Nuclear Information System (INIS)

    We have been studying radiative and collisional processes of highly charged heavy ions using two electron beam ion traps (EBITs) at the University of Electro-Communications (UEC/Tokyo); one is the Tokyo-EBIT constructed in 1995 for the operation with a high energy (up to 200 keV) electron beam, and another is “CoBIT” constructed recently for the operation with a low energy (< 1 keV) electron beam. Recent activities using the two EBITs are presented. (author)

  15. Electron Beam Spectrum Diagnostics with Optical Transition Radiation on the Beijing Free-Electron Laser

    Institute of Scientific and Technical Information of China (English)

    李泉凤; 吴频; 高建江; 吴刚

    2004-01-01

    A measurement system was developed to measure the electron beam spectrum of the Beijing free-electron laser based on the optical transition radiation (OTR). This paper describes the system, which consists of a 32-channel high resolution of 0.02% OTR detector, especially the spectrometer. The OTR angular-distribution pattern at the focal plane has two apexes, but the two apexes are smoothed out due to the electron beam energy distribution. The energy spectrum can be measured if the magnet energy resolution is higher than 0.7% to distinguish the electron beam energy distribution.

  16. Audit of high energy therapy beams in hospital oncology departments by the National Radiation Laboratory

    International Nuclear Information System (INIS)

    In 1993 the output of every high energy radiotherapy beam used clinically in New Zealand was measured by National Radiation Laboratory (NRL) staff using independent dosimetry equipment. The purpose of this was to audit the dosimetry that is used by hospital physicists for the basis of patient treatments, and to uncover any errors that may be clinically significant. This report analyses the uncertainties involved in comparing the NRL and hospital measurements, and presents the results of the 1993 audit. The overall uncertainty turns out to be about 1.5%. The results for linear accelerator photon beams are consistent with a purely random variation within this uncertainty. Electron beams show some small errors beyond the expected uncertainty. Gamma beams have the potential to be the most accurately measured, but in practice are less accurately measured than linear accelerator beams. None of the disagreements indicated an error of clinical significance. 8 refs., 3 figs., 2 tabs

  17. Time-Resolved Emittance Characterization of an Induction Linac Beam using Optical Transition Radiation

    International Nuclear Information System (INIS)

    An induction linac is used by Lawrence Livermore National Laboratory to perform radiographic testing at the Flash X-ray Radiography facility. Emittance characterization is important since x-ray spot size impacts the resolution of shadow-graphs. Due to the long pulse length, high current, and beam energy, emittance measurement using Optical Transition Radiation is an attractive alternative for reasons that will be described in the text. The utility of OTR-based emittance measurement has been well demonstrated for both RF and induction linacs. We describe the time-resolved emittance characterization of an induction linac electron beam. We have refined the optical collection system for the induction linac application, and have demonstrated a new technique for probing the divergence of a subset of the beam profile. The experimental apparatus, data reduction, and conclusions will be presented. Additionally, a new scheme for characterizing the correlation between beam divergence and spatial coordinates within the beam profile will be described

  18. Synchrotron Radiation and beam tube vacuum in a Very Large Hadron Collider; Stage 1 VLHC

    International Nuclear Information System (INIS)

    Synchrotron radiation induced photodesorption in particle accelerators may lead to pressure rise and to beam-gas scattering losses, finally affecting the beam lifetime. We discuss the beam tube vacuum in the low field Stage 1 Very Large Hadron Collider VLHC. Since VLHC Stage 1 has a room temperature beam tube, a non-evaporable getter (NEG St101 strip) pumping system located inside a pumping antechamber, supplemented by lumped ion pumps for pumping methane is considered. A possible beam conditioning scenario is presented for reaching design intensity. The most important results are summarized in this paper. More detailed reports of the calculations will be presented at the PAC2001 Conference, Chicago, IL to be held in June 2001, and at the Snowmass Conference, CO, to be held on July 2001

  19. Use of high-power electron beam radiation for the treatment of municipal and industrial wastes

    International Nuclear Information System (INIS)

    One of the factors impeding the use of ionizing radiation for waste treatment has been the relatively high cost of large radiation sources. This obstacle has been reduced by the recent development of powerful electron beam accelerators that are now being used by many manufacturers to crosslink plastic and rubber compounds, and to sterilize ethical products. The industrial demand for radiation processing equipment has produced a new technology which can be applied to the irradiation of waste materials. Electron accelerators can now provide 150 kW of useful beam power for continuous service. Such machines could process 3.1 MGD(million US gallons daily) of water to an average dose of 0.1 Mrad. The unit cost for the radiation process would be about $0.22 per 1000 gallons. Larger systems delivering up to a megawatt of power could be developed within a few years if needed for large-scale applications. Such equipment would bring the radiation processing cost down still further and would increase the capacity to about 22 MGD. This throughput would be comparable with the waste water effluent of large sewage treatment plants in the New York City area. High-power electron beams may be particularly useful in the treatment of gaseous wastes. The irradiation of stack gases from large electric power stations, a process that is now being investigated in Japan, is a possible application that could justify the development of multi-megawatt electron beam systems. (Author)

  20. Mo/Si multilayer-coated amplitude-division beam splitters for XUV radiation sources

    International Nuclear Information System (INIS)

    Short-wavelength XUV beam splitters consisting of multilayer reflective and transmissive coatings on 3 × 3 mm and 10 × 10 mm SiN membranes have been developed and fully characterized. Amplitude-division beam splitters for XUV radiation sources have been developed and extensively characterized. Mo/Si multilayer coatings were deposited on 50 nm-thick SiN membranes. By changing the multilayer structure (periodicity, number of bilayers, etc.) the intensity of the reflected and transmitted beams were optimized for selected incident radiation parameters (wavelength, incident angle). The developed optical elements were characterized by means of XUV reflectometry and transmission measurements, atomic force microscopy and optical interferometry. Special attention was paid to the spatial homogeneity of the optical response and reflected beam wavefront distortions. Here the results of the characterization are presented and improvements required for advanced applications at XUV free-electron lasers are identified. A flatness as low as 4 nm r.m.s. on 3 × 3 mm beam splitters and 22 nm r.m.s. on 10 × 10 mm beam splitters has been obtained. The high-spatial-frequency surface roughness was about 0.7–1 nm r.m.s. The middle-spatial-frequency roughness was in the range 0.2–0.8 nm r.m.s. The reflection and transmission of the beam splitters were found to be very homogeneous, with a deviation of less than 2% across the full optical element

  1. Optimal beam arrangement for stereotactic body radiation therapy delivery in lung tumors

    International Nuclear Information System (INIS)

    Purpose. To compare the different beam arrangement and delivery techniques for stereotactic body radiation therapy (SBRT) of lung lesions using the criteria of Radiation Therapy Oncology Group (RTOG) 0236 protocol. Material and methods. Thirty-seven medically inoperable lung cancers were evaluated with various planning techniques including multiple coplanar multiple static beams, multiple non-coplanar static beams and arc delivery. Twelve plans were evaluated for each case, including five plans using coplanar fixed beams, six plans using non-coplanar fixed beams and one plan using arc therapy. These plans were compared using the target prescription isodose coverage, high and low dose volumes, and critical organ dose-volume limits. Results. The prescription isodose coverage, high dose evaluation criteria and dose to critical organs were similar among treatment delivery techniques. However, there were differences in low dose criteria, especially in the ratio of the volume of 50% isodose of the prescription dose to the volume of planning treatment volume (R50%). The R50% in plans using non-coplanar static beams was lower than other plans in 30 of 37 cases (81%). Conclusion. Based on the dosimetric criteria outlined in RTOG 0236, the treatment technique using non-coplanar static beams showed the most preferable results for SBRT of lung lesions

  2. Enhancement of FEM radiation by prebunching of the e-beam (stimulated super-radiance)

    CERN Document Server

    Arbel, M; Kleinman, H; Yakover, I M; Abramovich, A; Pinhasi, Y; Luria, Y; Tecimer, M; Gover, A

    2001-01-01

    An electron beam (e-beam) prebunched at the synchronous FEM frequency and traversing through a waveguide, located coaxially with a magnetic undulator, emits coherent radiation at the bunching frequency. Introduction of both a premodulated e-beam and a radio-frequency (r.f.) signal at the same frequency at the input of the waveguide can lead to more efficient interaction, and thus more power can be extracted from the electron beam. In order to achieve this, the density modulation of the electron beam should be at an appropriate phase with respect to the r.f. signal. We report a first experimental demonstration of the influence of the phase difference between the r.f. input signal and the fundamental component of the density modulation of the e-beam on the radiated power in a Free-Electron Maser (FEM). Our experimental system allows control of the current density modulation, of the r.f. input power level, in the undulator region and of the phase between that r.f. input and the modulation of the e-beam. A compar...

  3. Generation of Shaped beam Radiation patterns from a Line source using Iterative sampling method

    Directory of Open Access Journals (Sweden)

    G.R.L.V.N.Srinivasa Raju

    2013-08-01

    Full Text Available For the generation of cosecant and trapezoidal radiation patterns an iterative sampling method is introduced by Stutzman. In this paper, an original radiation pattern which is some approximation to the desired radiation pattern is generated by a standard synthesis method and a series of correction patterns are applied to it by addinga correction pattern. This process is continued until the desired performance is achieved. In the present work, ramp, sector, cosecant, trapezoidal and stair stepped radiation patterns are generated using iterative procedure. The current distribution is found after corrections are applied. Studies are made with good number of examples, which showed that patterns with low side lobe level or low main beam ripple or sharp cut off from the main beam can be obtained. An iterative procedure is simple and converges rapidly.

  4. Prescription dose analysis and evaluation of carcinoma of breast on 60Co radiation beam

    International Nuclear Information System (INIS)

    To report the outcome of breast cancer patients treated radically by External Beam Radiotherapy (EBRT) and Chemotherapy. Radiation therapy along with chemotherapy plays an important role in the treatment of breast cancer. In breast tumour management the role of post mastectomy chest wall irradiation in improving the local control is well known. It is important to practice optimal radiation therapy in order to achieve high loco-regional control with minimal morbidity

  5. Generation of Longitudinally Polarised Terahertz Radiation for the Energy Manipulation of Relativistic Electron Beams

    OpenAIRE

    Cliffe, Matthew

    2016-01-01

    The University of Manchester Matthew J. Cliffe Doctor of Philosophy Generation of Longitudinally Polarised Terahertz Radiation for the Energy Manipulation of Relativistic Electron BeamsSeptember 2015The acceleration of charged particles with ultrafast terahertz electromagnetic radiation could enable new, and improve many of aspects of, accelerator applications. These include providing shorter electron bunches for ultrafast time-resolved pump-probe spectroscopy, enabling complex longitudinal p...

  6. Dosimetric Audits of Photon Beams in Radiation Therapy Centres

    International Nuclear Information System (INIS)

    Data related to eleven years of high-energy photon radiotherapy beams dosimetry are presented and analyzed. Dosimetric evaluations were carried out using water phantoms and thimble ionization chambers. Measurements were done at reference conditions for a standard absorbed dose of 100 cGy. The first dosimetry surveys from 1996 to 1998 showed deviations of 22% and 18.7%, although small deviations were also obtained. After 1998 the improvement of dosimetry quality control by the radiotherapy centers became clear, with most of the deviations situated within the ±3% range. (author)

  7. Particle beams in ultrastrong laser fields: direct laser acceleration and radiation reaction effects

    Science.gov (United States)

    Salamin, Yousef I.; Li, Jian-Xing; Hatsagortsyan, Karen Z.; Tamburini, Matteo; Di Piazza, Antonino; Keitel, Christoph H.

    2015-03-01

    Several aspects of the interaction of particle beams with ultrastrong laser fields are discussed. Firstly, we consider regimes when radiation reaction is not essential and it is demonstrated that employing chirped laser pulses, significant improvement of the direct acceleration of particles can be achieved. Results from single- and many-particle calculations of the particle acceleration, in vacuum, by plane-wave fields, as well as in tightly-focused laser beams, show that the mean energies and their spreads qualify them for important applications. Secondly, we investigate the effect of radiation reaction in electron-laser-beam interactions. Signatures of the quantum radiation reaction during the interaction of an electron bunch with a focused superstrong ultrashort laser pulse can be observed in a characteristic behavior of the spectral bandwidth, and the angular spread of the nonlinear Compton radiation on the laser pulse duration. Furthermore, it is shown that the radiation reaction effects can be employed to control the electron dynamics via the nonlinear interplay between the Lorentz and radiation reaction forces. In particular, it is shown that an ultrarelativistic electron bunch colliding head- on with a strong bichromatic laser pulse can be deflected in a controllable way, by changing either the relative phase or the relative amplitude between the two frequency components of the bichromatic field.

  8. Study of performance of electronic dosemeters in continuous and pulsed X-radiation beams

    International Nuclear Information System (INIS)

    Personal radiation monitoring is a basic procedure to verify the compliance to regulatory requirements for radiological protection. Electronic personal dosimeters (EPD) based on solid state detectors have largely been used for personnel monitoring; including for pulsed radiation beams where their responses are not well known and deficiencies have been reported. In this work, irradiation conditions for testing the response of EPDs in both continuous and pulsed X-ray beams were studied to be established in a constant potential Seifert-Pantak and in a medical Pulsar 800 Plus VMI X-ray machines. Characterization of X-ray beams was done in terms of tube voltage, half-value layer, mean energy and air kerma rate. A Xi R/F Unfors solid state dosimeter used as reference for air kerma measurements was verified against a RC-6 and 10X6-6 Radical ionization chambers as far its metrological coherence. Rad-60 RADOS, PDM- 11 Aloka and EPD MK2 Thermo electron EPDs were selected to be tested in terms of relative intrinsic error and energy response in similar to IEC RQR, IEC RQA and ISO N reference radiations. Results demonstrated the reliability of the solid state Xi R/F Unfors dosimeter to be as reference dosimeter although its response was affected by heavily filtered beams. Results also showed that relative intrinsic errors in the response of the EPDs in terms of personal dose equivalent, Hp(10), were higher than the requirement established for continuous beams. In pulsed beams, some EPDs showed inadequate response and high relative intrinsic errors. This work stressed the need of performing additional checks for EPDs, besides the limited 137Cs beam calibration, before using them in pulsed X-ray beams. (author)

  9. Normal tissue tolerance to external beam radiation therapy: Skin

    International Nuclear Information System (INIS)

    Acute skin toxicity is frequent during radiation therapy and can lead to temporary arrest of the treatment. Chronic toxicity can occur and conduct to cosmetic problems. Alopecia is the most frequent toxicity concerning hair and is most of the time reversible. Several factors linked to patients influence skin toxicity, such as under-nutrition, old age, obesity, smoking, skin diseases, autoimmune diseases, failure of DNA reparation. Skin, hair and nail toxicities depend also on radiation schedule. Acute toxicity is greater when dose per fraction increases. Chronic and acute toxicities are more often when total dose increases. Under 45 Gy, the risk of severe skin toxicity is low, and begins above 50 Gy. Skin toxicity depends also on the duration of radiotherapy and split course schedules are associated with less toxicities. Irradiation surface seems to influence skin toxicity but interaction is more complex. Reirradiation is often feasible in case of cancer recurrence but with a risk of grade 3-4 toxicity above all in head and neck cancer. The benefit/risk ratio has to be always precisely evaluated. Permanent alopecia is correlated with the follicle dose. Modern techniques of radiation therapy allow to spare skin. (authors)

  10. Electron beam excitation of a CSRR loaded waveguide for Cherenkov radiation

    Science.gov (United States)

    Sharples, Emmy; Letizia, Rosa

    2015-09-01

    A novel metamaterial structure is presented for applications as a backward propagating Cherenkov source or Cherenkov detector. The structure comprises of a complementary split ring resonator (CSRR) metasurface loaded waveguide, which exhibits left handed behaviour between 5-6 GHz. When the left handed, TM-like mode couples with an incident electron beam, backward propagating Cherenkov radiation is observed. The structure is suitable for beam-based applications, exhibiting strong beam coupling parameters and significant excitation of longitudinal wakefields. Three dimensional particle in cell simulations are performed to identify a suitable beam for operation. High and low energy beams, with different bunch dimensions from the literature, are considered and compared to investigate the nature of the beam-wave interaction this structure can support, and to identify any required modification before beam tests can be performed. This structure can lead to new solutions for non-destructive beam diagnostics, wakefield acceleration and backward wave oscillators which can potentially be scaled to higher frequency ranges.

  11. Smith-Purcell radiation from a 50 MeV beam

    International Nuclear Information System (INIS)

    A 50 MeV electron beam and a 1 mm period, 5 degree blaze, echelle grating have been used to produce radiation in the mid-infrared spectral region. The emission is highly collimated and forward-directed. The intensity level in the few ps pulse (2 nJ/sr) indicates a degree of coherent enhancement

  12. Reflection of parametric X-ray radiation at the right angle to the particle beam

    International Nuclear Information System (INIS)

    The angular distribution (AD) of the yield in the reflection of parametric X-ray radiation (PXR), generated by relativistic particles in a crystal at the right angle to the particle beam, is considered theoretically. It is shown that the AD should have five singular points. 23 refs., 2 figs

  13. Cherenkov imaging during volumetric modulated arc therapy for real-time radiation beam tracking and treatment response monitoring

    Science.gov (United States)

    Andreozzi, Jacqueline M.; Zhang, Rongxiao; Glaser, Adam K.; Gladstone, David J.; Jarvis, Lesley A.; Pogue, Brian W.

    2016-03-01

    External beam radiotherapy utilizes high energy radiation to target cancer with dynamic, patient-specific treatment plans. The otherwise invisible radiation beam can be observed via the optical Cherenkov photons emitted from interaction between the high energy beam and tissue. Using a specialized camera-system, the Cherenkov emission can thus be used to track the radiation beam on the surface of the patient in real-time, even for complex cases such as volumetric modulated arc therapy (VMAT). Two patients undergoing VMAT of the head and neck were imaged and analyzed, and the viability of the system to provide clinical feedback was established.

  14. Transmissivities of radiation beams and particle beams in multicomponent mixed materials. 2. Finite Markov chain model

    International Nuclear Information System (INIS)

    This paper is a complement to an earlier paper on the transmissivity of beams in multi-component mixed materials of identical grain size and presents an analytical expression of transmissivity based on the finite Markov chain in the case of mixed materials of different grain sizes. The expression is represented by the flux vector and the response matrix obtained from the transition matrix. (author)

  15. Alanine Radiation Detectors in Therapeutic Carbon Ion Beams

    DEFF Research Database (Denmark)

    Herrmann, Rochus; Jäkel, Oliver; Palmans, Hugo;

        Radiotherapy with particles is getting more attention in Europe. New facilities for protons and heavier ions are finished, or near to the final status, some more are planed. Particle therapy with heavy ions is a challenge to dosimetry, since mixed particle fields occur in the peak region...... of the depth dose curves. Solid state detectors, such as diamond detectors, radiochromic films, TLDs and the amino acid alanine are used due to there good spatial resolution. If used in particle beams their response often exhibits a dependence on particle energy and type, so the acquired signal is not always...... proportional to absorbed dose. A model by Hansen and Olsen, based on the Track Structure Theory is available, which can predict the relative efficiency of some detectors, when the particle spectrum is known. For alanine detectors the model was successfully validated by Hansen and Olsen for several ion species...

  16. Electron beam radiation of unsaturated polyester-styrene systems

    International Nuclear Information System (INIS)

    Polyester resins prepared by mixing the unsaturated polyester and styrene with the weight ratio is 70 : 30 was irradiated using low energy electron beam. The influence of irradiation dose, composition and molecular-weight to the film properties were studied. Physical and mechanical such as hardness, abrasion resistence, tensile strength and elongation at break were evaluated. It was found that polyester film prepared from backbone base on isophthalic acid, fumaric acid, propylene glycol, diethyl glycol and glycerol, gave the best properties compared with others. At the dose of 100 kGy and dose rate of 26 kGy/sec., the gel-fraction was 93.1% tensile strength was about 440 Kg/cm2 and a hardeness of 4 H. (authors). 8 refs, 5 figs, 2 tabs

  17. Characteristics of the programme of dose calculation in the area of irregular entry fields of cobalt radiation beams

    International Nuclear Information System (INIS)

    The programme of calculating the doses in the areas of irregular entry fields of cobalt radiation beam is described. The calculations were carried out in a plane perpendicular to the axis of the beam (one or two opposite beams). The programme is written in the FORTRAN language and used in conversation mode in a set of Informatek minicomputer. (author)

  18. A novel method involving Matlab coding to determine the distribution of a collimated ionizing radiation beam

    Science.gov (United States)

    Ioan, M.-R.

    2016-08-01

    In ionizing radiation related experiments, precisely knowing of the involved parameters it is a very important task. Some of these experiments are involving the use of electromagnetic ionizing radiation such are gamma rays and X rays, others make use of energetic charged or not charged small dimensions particles such are protons, electrons, neutrons and even, in other cases, larger accelerated particles such are helium or deuterium nuclei are used. In all these cases the beam used to hit an exposed target must be previously collimated and precisely characterized. In this paper, a novel method to determine the distribution of the collimated beam involving Matlab coding is proposed. The method was implemented by using of some Pyrex glass test samples placed in the beam where its distribution and dimension must be determined, followed by taking high quality pictures of them and then by digital processing the resulted images. By this method, information regarding the doses absorbed in the exposed samples volume are obtained too.

  19. Calculation of synchrotron radiation from high intensity electron beam at eRHIC

    Energy Technology Data Exchange (ETDEWEB)

    Jing Y.; Chubar, O.; Litvinenko, V.

    2012-05-20

    The Electron-Relativistic Heavy Ion Collider (eRHIC) at Brookhaven National Lab is an upgrade project for the existing RHIC. A 30 GeV energy recovery linac (ERL) will provide a high charge and high quality electron beam to collide with proton and ion beams. This will improve the luminosity by at least 2 orders of magnitude. The synchrotron radiation (SR) from the bending magnets and strong quadrupoles for such an intense beam could be penetrating the vacuum chamber and producing hazards to electronic devices and undesired background for detectors. In this paper, we calculate the SR spectral intensity, power density distributions and heat load on the chamber wall. We suggest the wall thickness required to stop the SR and estimate spectral characteristics of the residual and scattered background radiation outside the chamber.

  20. Photon beam audits for radiation therapy clinics: A pilot mailed dosemeter study in Turkey

    International Nuclear Information System (INIS)

    A thermoluminescent dosemeter (TLD) mailed dose audit programme was performed at five radiotherapy clinics in Turkey. The intercomparison was organised by the Univ. of Wisconsin Radiation Calibration Laboratory (UWRCL), which was responsible for the technical aspects of the study including reference irradiations, distribution, collection and evaluation. The purpose of these audits was to perform an independent dosimetry check of the radiation beams using TLDs sent by mail. Acrylic holders, each with five TLD chips inside and instructions for their irradiation to specified absorbed dose to water of 2 Gy, were mailed to all participating clinics. TLD irradiations were performed with a 6 MV linear accelerator and 60Co photon beams. The deviations from the TL readings of UWRCL were calculated. Discrepancies inside the limits of ±5 % between the participant-stated dose, and the TLD-measured dose were considered acceptable. One out of 10 beams checked was outside this limit, with a difference of 5.8 %. (authors)

  1. Ion beam induced charge and cathodoluminescence imaging of response uniformity of CVD diamond radiation detectors

    CERN Document Server

    Sellin, P J; Galbiati, A; Maghrabi, M; Townsend, P D

    2002-01-01

    The uniformity of response of CVD diamond radiation detectors produced from high quality diamond film, with crystallite dimensions of >100 mu m, has been studied using ion beam induced charge imaging. A micron-resolution scanning alpha particle beam was used to produce maps of pulse height response across the device. The detectors were fabricated with a single-sided coplanar electrode geometry to maximise their sensitivity to the surface region of the diamond film where the diamond crystallites are highly ordered. High resolution ion beam induced charge images of single crystallites were acquired that demonstrate variations in intra-crystallite charge transport and the termination of charge transport at the crystallite boundaries. Cathodoluminescence imaging of the same crystallites shows an inverse correlation between the density of radiative centres and regions of good charge transport.

  2. Development and application of a dosimetric methodology of therapeutic X radiation beams using a tandem system

    International Nuclear Information System (INIS)

    In radiotherapy the use of orthovoltage X radiation beams is still recommended; to obtain satisfactory results, a periodic control is necessary to check the performance of the ionization chambers and the radiation beams characteristics. This control is performed by using standard dosimetric procedures, as for example the determination of half-value layers and the absorbed dose rates. A Tandem system was established in this work using a pair of ionization chambers (a thimble type and a superficial type) used for measures in a medical institution, in substitution to the routine conventional procedure of determination of half-value layers using absorbers. The results obtained show the application of this method in dosimetric procedures of orthovoltage beams (radiotherapy) as a complement for a quality control program. (author)

  3. Study of filamentation dynamics of ultrashort laser radiation in air: beam diameter effect

    International Nuclear Information System (INIS)

    A single filamentation of femtosecond gigawatt laser radiation with a millimeter-size aperture upon collimated and sharply focused propagation in atmospheric air at 800 nm and 400 nm wavelengths is studied both theoretically and experimentally. The influence of beam initial radius on the parameters of the forming filament is analyzed. Three filament parameters, namely, start coordinate, filament length, and longitudinal continuity are considered. We report that unlike Marburger’s formula the single filamentation onset reveals marked nonquadratic dependence on the laser beam radius providing the same initial pulse power. Additionally, for sharply focused radiation the minor dependence of the filament length on the laser beam diameter at the constant initial pulse intensity was experimentally revealed. (paper)

  4. Observation of Spontaneous Emitted X-ray Betatron Radiation in Beam-Plasma Interactions

    International Nuclear Information System (INIS)

    An experiment is being carried out at the Stanford Linear Accelerator Center (SLAC) to see if an ion channel can wiggle a beam of ultra-relativistic electrons to produce x-ray radiation. The goal is to create an intense source of undulator radiation using a plasma wiggler in the 1-10 KeV range and also to determine the suitability of such an electrostatic wiggler to create a coherent beam of x-rays via the ion channel laser mechanism [1]. Here we give some of the scaling laws for the power and frequency distribution of the spontaneous emission from sending an electron beam through such an ion channel. Some initial experimental observations are also presented

  5. The NASA Space Radiation Laboratory at Brookhaven National Laboratory: Preparation and delivery of ion beams for space radiation research

    International Nuclear Information System (INIS)

    The NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL) was commissioned in October 2002 and became operational in July 2003. The NSRL was constructed in collaboration with NASA for the purpose of performing space radiation research as part of the NASA space program. The NSRL can accept a wide variety of ions from BNL's Collider Accelerator Department (CAD) Booster accelerator. These ion beams are extracted from the accelerator with kinetic energies ranging from 0.05 to 3 GeV/nucleon. Many different beam conditions have been produced for experiments at NSRL. The facilities at BNL and the design of the NSRL facility permit a wide variety of beams to be produced with a great degree of flexibility in the delivery of ion beams to experiments. In this report we will describe the facility and its performance over the eight experimental run periods that have taken place since it became operational. We will also describe the current and future capabilities of the NSRL.

  6. Spatial resolution in optical transition radiation (OTR) beam diagnostics

    International Nuclear Information System (INIS)

    An evaluation of the OTR single particle image dimension is obtained using diffraction theory based on a realistic description of the radiation source. This approach allows the analysis of the effect of the finite size of the emitting screen and of the imaging system. The role of practical experimental conditions in treating the intensity tail problem is estimated. It is shown that by exploiting the polarization properties of OTR, a considerable enhancement in the spatial resolution can be achieved, which becomes very similar to that of a standard point source

  7. External beam radiation for retinoblastoma: Results, patterns of failure, and a proposal for treatment guidelines

    International Nuclear Information System (INIS)

    Purpose: To analyze treatment results and patterns of failure following external beam radiation for retinoblastoma and propose treatment guidelines according to specific clinical variables. Methods and Materials: We analyzed 27 patients (34 eyes) with retinoblastoma who received external beam radiation as initial treatment at Hahnemann University Hospital from October 1980 to December 1991 and have been followed for at least 1 year. Of the 34 eyes, 14 were Groups I-II (Reese-Ellsworth classification), 7 were Group III, and 13 were Groups IV-V. Doses ranged from 34.5-49.5 Gy (mean 44.3 Gy, median 45 Gy) in 1.5-2.0 Gy fractions generally delivered through anterior and lateral wedged pair fields. Results: At a mean follow up of 35.2 months (range 12-93 months), local tumor control was obtained in 44% (15 out of 34) of eyes with external beam radiation alone. Salvage therapy (plaque brachytherapy, cryotherapy, and/or photocoagulation) controlled an additional 10 eyes (29.5%), so that overall ocular survival has been 73.5%. Local tumor control with external beam radiotherapy alone was obtained in 78.5% (11 out of 14) of eyes in Groups I-II, but in only 20% (4 out of 20) of eyes in Groups III-V. A total of 67 existing tumors were identified prior to treatment in the 34 treated eyes and local control with external beam radiation alone was obtained in 87% (46 out of 53) of tumors measuring 15 mm or less and in 50% (7 out of 14) of tumors measuring more than 15 mm. When analyzing patterns of failure in the 19 eyes that relapsed, a total of 28 failure sites were identified and consisted of progression of vitreous seeds in seven instances (25% of failure sites) recurrences from previously existing tumors in 10 instances (36% of failure sites) and development of new tumors in previously uninvolved retina in 11 instances (39% of failure sites). Conclusions: 1) We find that external beam radiation to a dose of 45 Gy in fractions of 1.5 to 2.0 Gy provides adequate tumor control

  8. Dynamic optical modulation of an electron beam on a photocathode RF gun: Toward intensity-modulated radiation therapy (IMRT)

    International Nuclear Information System (INIS)

    In intensity-modulated radiation therapy (IMRT), the aim is to deliver reduced doses of radiation to normal tissue. As a step toward IMRT, we examined dynamic optical modulation of an electron beam produced by a photocathode RF gun. Images on photomasks were transferred onto a photocathode by relay imaging. The resulting beam was controlled by a remote mirror. The modulated electron beam maintained its shape on acceleration, had a fine spatial resolution, and could be moved dynamically by optical methods

  9. Dynamic optical modulation of an electron beam on a photocathode RF gun: Toward intensity-modulated radiation therapy (IMRT)

    Science.gov (United States)

    Kondoh, Takafumi; Kashima, Hiroaki; Yang, Jinfeng; Yoshida, Yoichi; Tagawa, Seiichi

    2008-10-01

    In intensity-modulated radiation therapy (IMRT), the aim is to deliver reduced doses of radiation to normal tissue. As a step toward IMRT, we examined dynamic optical modulation of an electron beam produced by a photocathode RF gun. Images on photomasks were transferred onto a photocathode by relay imaging. The resulting beam was controlled by a remote mirror. The modulated electron beam maintained its shape on acceleration, had a fine spatial resolution, and could be moved dynamically by optical methods.

  10. Metrology and quality of radiation therapy dosimetry of electron, photon and epithermal neutron beams

    International Nuclear Information System (INIS)

    In radiation therapy using electron and photon beams the dosimetry chain consists of several sequential phases starting by the realisation of the dose quantity in the Primary Standard Dosimetry Laboratory and ending to the calculation of the dose to a patient. A similar procedure can be described for the dosimetry of epithermal neutron beams in boron neutron capture therapy (BNCT). To achieve the required accuracy of the dose delivered to a patient the quality of all steps in the dosimetry procedure has to be considered. This work is focused on two items in the dosimetry chains: the determination of the dose in the reference conditions and the evaluation of the accuracy of dose calculation methods. The issues investigated and discussed in detail are: a)the calibration methods of plane parallel ionisation chambers used in electron beam dosimetry, (b) the specification of the critical dosimetric parameter i.e. the ratio of stopping powers for water to air, (S I ?)waterair, in photon beams, (c) the feasibility of the twin ionization chamber technique for dosimetry in epithermal neutron beams applied to BNCT and (d) the determination accuracy of the calculated dose distributions in phantoms in electron, photon, and epithermal neutron beams. The results demonstrate that up to a 3% improvement in the consistency of dose determinations in electron beams is achieved by the calibration of plane parallel ionisation chambers in high energy electron beams instead of calibrations in 60Co gamma beams. In photon beam dosimetry (S I ?)waterair can be determined with an accuracy of 0.2% using the percentage dose at the 10 cm depth, %dd(10), as a beam specifier. The use of %odd(10) requires the elimination of the electron contamination in the photon beam. By a twin ionisation chamber technique the gamma dose can be determined with uncertainty of 6% (1 standard deviation) and the total neutron dose with an uncertainty of 15 to 20% (1 standard deviation). To improve the accuracy of

  11. Metrology and quality of radiation therapy dosimetry of electron, photon and epithermal neutron beams

    Energy Technology Data Exchange (ETDEWEB)

    Kosunen, A

    1999-08-01

    In radiation therapy using electron and photon beams the dosimetry chain consists of several sequential phases starting by the realisation of the dose quantity in the Primary Standard Dosimetry Laboratory and ending to the calculation of the dose to a patient. A similar procedure can be described for the dosimetry of epithermal neutron beams in boron neutron capture therapy (BNCT). To achieve the required accuracy of the dose delivered to a patient the quality of all steps in the dosimetry procedure has to be considered. This work is focused on two items in the dosimetry chains: the determination of the dose in the reference conditions and the evaluation of the accuracy of dose calculation methods. The issues investigated and discussed in detail are: a)the calibration methods of plane parallel ionisation chambers used in electron beam dosimetry, (b) the specification of the critical dosimetric parameter i.e. the ratio of stopping powers for water to air, (S I ?){sup water} {sub air}, in photon beams, (c) the feasibility of the twin ionization chamber technique for dosimetry in epithermal neutron beams applied to BNCT and (d) the determination accuracy of the calculated dose distributions in phantoms in electron, photon, and epithermal neutron beams. The results demonstrate that up to a 3% improvement in the consistency of dose determinations in electron beams is achieved by the calibration of plane parallel ionisation chambers in high energy electron beams instead of calibrations in {sup 60}Co gamma beams. In photon beam dosimetry (S I ?){sup water} {sub air} can be determined with an accuracy of 0.2% using the percentage dose at the 10 cm depth, %dd(10), as a beam specifier. The use of %odd(10) requires the elimination of the electron contamination in the photon beam. By a twin ionisation chamber technique the gamma dose can be determined with uncertainty of 6% (1 standard deviation) and the total neutron dose with an uncertainty of 15 to 20% (1 standard deviation

  12. Efficient, radiation-hardened, 800-keV neutral beam injection system

    International Nuclear Information System (INIS)

    Recent advances and new concepts in negative ion generation, transport, acceleration, and neutrailzation make it appear likely that an efficient, radiation-hardened neutral beam injection system could be developed in time for the proposed FED-A tokamak. These new developments include the operation of steady-state H- ion sources at over 5 A per meter of source length, the concept of using strong-focussing electrostatic structures for low-gradient dc acceleration of high-current sheet beams of negative ions and the transport of these beams around corners, and the development of powerful oxygen-iodine chemical lasers which will make possible the efficient conversion of the negative ions to neutrals using a photodetachment scheme in which the ion beam passes through the laser cavity

  13. Time-Resolved Emittance Characterization of an Induction Linac Beam using Optical Transition Radiation

    CERN Document Server

    Le Sage, G P

    2002-01-01

    An induction linac is used by Lawrence Livermore National Laboratory to perform radiographic testing at the Flash X-ray Radiography facility. Emittance characterization is important since x-ray spot size impacts the resolution of shadow-graphs. Due to the long pulse length, high current, and beam energy, emittance measurement using Optical Transition Radiation is an attractive alternative for reasons that will be described in the text. The utility of OTR-based emittance measurement has been well demonstrated for both RF and induction linacs. We describe the time-resolved emittance characterization of an induction linac electron beam. We have refined the optical collection system for the induction linac application, and have demonstrated a new technique for probing the divergence of a subset of the beam profile. The experimental apparatus, data reduction, and conclusions will be presented. Additionally, a new scheme for characterizing the correlation between beam divergence and spatial coordinates within the b...

  14. A high rate transition radiation detector for particle identification in a hadron beam

    International Nuclear Information System (INIS)

    A Transition Radiation Detector (TRD) was built for the purpose of tagging beam particles in a high rate (∼2 MHz) 250 GeV/c hadron beam during data taking for Experiment 769 at Fermilab. The availability of a good ''tool kit'', including a Monte Carlo program which could reliably predict the detector performance, made it possible to design and build the TRD in approximately one year. Pion or proton samples, each with a small contamination due to the other, could be selected with high efficiency by making cuts on the number of planes of the TRD registering hits for each incident beam particle. The detector is expected to work well to separate kaons from pions in the 500 GeV/c negative beam for E791. 15 refs., 8 figs., 1 tab

  15. Electromagnetic Coupling Between High Intensity LHC Beams and the Synchrotron Radiation Monitor Light Extraction System

    CERN Document Server

    Andreazza, W; Bravin, E; Caspers, F; Garlasch`e, M; Gras, J; Goldblatt, A; Lefevre, T; Jones, R; Metral, E; Nosych, A; Roncarolo_, F; Salvant, B; Trad, G; Veness, R; Vollinger, C; Wendt, M

    2013-01-01

    The CERN LHC is equipped with two Synchrotron Radiation Monitor (BSRT) systems used to characterise transverse and longitudinal beam distributions. Since the end of the 2011 LHC run the light extraction system, based on a retractable mirror, has suffered deformation and mechanical failure that is correlated to the increase in beam intensity. Temperature probes have associated these observations to a strong heating of the mirror support with a dependence on the longitudinal bunch length and shape, indicating the origin as electromagnetic coupling between the beam and the structure. This paper combines all this information with the aim of characterising and improving the system in view of its upgrade during the current LHC shutdown. Beam-based observations are presented along with electromagnetic and thermomechanical simulations and complemented by laboratory measurements, including the study of the RF properties of different mirror bulk and coating materials.

  16. Quantum radiation reaction in head-on laser-electron beam interaction

    CERN Document Server

    Vranic, Marija; Fonseca, Ricardo A; Silva, Luis O

    2015-01-01

    In this paper, we investigate the evolution of the energy spread and the divergence of electron beams while they interact with different laser pulses at intensities where quantum effects and radiation reaction are of relevance. The interaction is modeled with a QED-PIC code and the results are compared with those obtained with a standard PIC code with the addition of a classical radiation reaction module and with theoretical predictions. While classical radiation reaction is a continuous process, in QED, radiation emission is stochastic. The two pictures reconcile in the limit when the emitted photons energy is small compared to the energy of the emitting electrons. The energy spread of the electron distribution function always tends to decrease with classical radiation reaction, whereas the stochastic QED emission can also enlarge it. These two tendencies compete in the QED-dominated regime. Our analysis, supported by the QED module, reveals an upper limit to the maximal attainable energy spread due to stoch...

  17. Detector Response and Beam Line Transmission Measurements with Far-Infrared Radiation

    CERN Document Server

    Grimm, O; Fröhlich, L

    2005-01-01

    Various activities at the TTF linear accelerator at DESY, Hamburg, that drives the VUV-FEL are geared towards measuring the longitudinal charge distribution of electron bunches with coherent far-infrared radiation. Examples are beam lines transporting synchrotron or transition radiation to interferometers mounted inside or outside the tunnel, and studies of single-shot grating spectrometers. All such approaches require a good understanding of the radiation generation and transport mechanism and of the detector characteristics to extract useful information on the charge distribution. Simulations and measurements of the expected transverse intensity distribution and polarization of synchrotron radiation emitted at the first bunch compressor of TTF have been performed. The transverse intensity scanning provided for the first time at DESY a visual image of the footprint of terahertz radiation. Detector response measurements have been performed at the FELIX facility, Netherlands, for wavelengths between 100-160 mi...

  18. Effect of electron-beam radiation on graphite epoxy composites

    International Nuclear Information System (INIS)

    Specimens of unidirectional graphite/epoxy laminates were irradiated by 10-MeV electrons up to a total dose of 5000 Mrads at 50, 150, and 250 C and then tested mechanically to determine their flexural and interlaminar shear strengths. The radiation-generated volatile products and the components extracted by a solvent from the irradiated specimens were analyzed by gas-chromatographic and mass spectrometric techniques; the degradation of the matrix resin (bisphenol based epoxy) was characterized by FT-IR spectroscopy. It is found that the flexural strength of the specimens irradiated in air decreases with increasing dose. The flexural strength of the irradiated specimens, however, can be almost completely restored through a thermal cycling treatment. It is also shown that the degradation of the matrix increases with the irradiation dose. 9 references

  19. Normal tissue tolerance to external beam radiation therapy: Peripheral nerves

    International Nuclear Information System (INIS)

    Plexopathies and peripheral neuropathies appear progressively and with several years delay after radiotherapy. These lesions are observed principally after three clinical situations: supraclavicular and axillar irradiations for breast cancer, pelvic irradiations for various pathologies and limb irradiations for soft tissue sarcomas. Peripheral nerves and plexus (brachial and lumbosacral) are described as serial structures and are supposed to receive less than a given maximum dose linked to the occurrence of late injury. Literature data, mostly ancient, define the maximum tolerable dose to a threshold of 60 Gy and highlight also a great influence of fractionation and high fraction doses. For peripheral nerves, most frequent late effects are pain with significant differences of occurrence between 50 and 60 Gy. At last, associated pathologies (diabetes, vascular pathology, neuropathy) and associated treatments have probably to be taken into account as additional factors, which may increase the risk of these late radiation complications. (authors)

  20. Beam orientation optimization for intensity modulated radiation therapy using adaptive l2,1-minimization

    Science.gov (United States)

    Jia, Xun; Men, Chunhua; Lou, Yifei; Jiang, Steve B.

    2011-10-01

    Beam orientation optimization (BOO) is a key component in the process of intensity modulated radiation therapy treatment planning. It determines to what degree one can achieve a good treatment plan in the subsequent plan optimization process. In this paper, we have developed a BOO algorithm via adaptive l2, 1-minimization. Specifically, we introduce a sparsity objective function term into our model which contains weighting factors for each beam angle adaptively adjusted during the optimization process. Such an objective function favors a small number of beam angles. By optimizing a total objective function consisting of a dosimetric term and the sparsity term, we are able to identify unimportant beam angles and gradually remove them without largely sacrificing the dosimetric objective. In one typical prostate case, the convergence property of our algorithm, as well as how beam angles are selected during the optimization process, is demonstrated. Fluence map optimization (FMO) is then performed based on the optimized beam angles. The resulting plan quality is presented and is found to be better than that of equiangular beam orientations. We have further systematically validated our algorithm in the contexts of 5-9 coplanar beams for five prostate cases and one head and neck case. For each case, the final FMO objective function value is used to compare the optimized beam orientations with the equiangular ones. It is found that, in the majority of cases tested, our BOO algorithm leads to beam configurations which attain lower FMO objective function values than those of corresponding equiangular cases, indicating the effectiveness of our BOO algorithm. Superior plan qualities are also demonstrated by comparing DVH curves between BOO plans and equiangular plans.

  1. Pertinence analysis of intensity-modulated radiation therapy dosimetry error and parameters of beams

    International Nuclear Information System (INIS)

    Objective: To study the relationship between parameter settings in the intensity-modulated radiation therapy (IMRT) planning in order to explore the effect of parameters on absolute dose verification. Methods: Forty-three esophageal carcinoma cases were optimized with Pinnacle 7.6c by experienced physicist using appropriate optimization parameters and dose constraints with a number of iterations to meet the clinical acceptance criteria. The plans were copied to water-phantom, 0.13 cc ion Farmer chamber and DOSE1 dosimeter was used to measure the absolute dose. The statistical data of the parameters of beams for the 43 cases were collected, and the relationships among them were analyzed. The statistical data of the dosimetry error were collected, and comparative analysis was made for the relation between the parameters of beams and ion chamber absolute dose verification results. Results: The parameters of beams were correlated among each other. Obvious affiliation existed between the dose accuracy and parameter settings. When the beam segment number of IMRT plan was more than 80, the dose deviation would be greater than 3%; however, if the beam segment number was less than 80, the dose deviation was smaller than 3%. When the beam segment number was more than 100, part of the dose deviation of this plan was greater than 4%. On the contrary, if the beam segment number was less than 100, the dose deviation was smaller than 4% definitely. Conclusions: In order to decrease the absolute dose verification error, less beam angles and less beam segments are needed and the beam segment number should be controlled within the range of 80. (authors)

  2. Integrating and automating the software environment for the Beam and Radiation Monitoring for CMS

    CERN Document Server

    Filyushkina, Olga; Juslin, J

    2010-01-01

    The real-time online visualization framework used by the Beam and Radiation Monitoring group at the Compact Muon Solenoid at Large Hadron Collider, CERN. The purpose of the visualization framework is to provide real-time diagnostic of beam conditions, which defines the set of the requirements to be met by the framework. Those requirements include data quality assurance, vital safety issues, low latency, data caching, etc. The real-time visualization framework is written in the Java programming language and based on JDataViewer--a plotting package developed at CERN. At the current time the framework is run by the Beam and Radiation Monitoring, Pixel, Tracker groups, Run Field Manager and others. It contributed to real-time data analysis during 2009-2010 runs as a stable monitoring tool. The displays reflect the beam conditions in a real-time with the low latency level, thus it is the first place at the CMS detector where the beam collisions are observed.

  3. Use of XR-QA2 radiochromic films for quantitative imaging of a synchrotron radiation beam

    International Nuclear Information System (INIS)

    In the framework of an ongoing project, promoted by INFN, at the SYRMEP beamline of the ELETTRA synchrotron radiation facility (Trieste, Italy) for phase-contrast breast X-ray computed tomography, the assessment of the dose to the breast is one of the issues, requiring the determination of the distribution of X-ray incident photon fluence. This work investigates the use of XR-QA2 radiochromic films for quantitative imaging of the synchrotron radiation (SR) beam. XR-QA2 films were irradiated in a plane transverse to the beam axis, with a monochromatic beam of energy of 28, 35, 38 or 40 keV. The response of the radiochromic film was calibrated in terms of average air kerma measured with an ionization chamber. The net reflectance of the exposed film was then converted to photon fluence per unit air kerma (mm−2mGy−1). The SR beam profile was acquired also with a scintillator (GOS) based, fiber optic coupled CCD camera as well as with a scintillator based flat panel detector. Horizontal and vertical line profiles acquired with the radiochromic films show the 2D distribution of the beam intensity, with variations in the order of 15–20% in the horizontal direction. The response of the radiochromic film is comparable to that of the other imaging detectors, within less than 5% variation

  4. Comprehensive MRI simulation methodology using a dedicated MRI scanner in radiation oncology for external beam radiation treatment planning

    Energy Technology Data Exchange (ETDEWEB)

    Paulson, Eric S., E-mail: epaulson@mcw.edu [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 and Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States); Erickson, Beth; Schultz, Chris; Allen Li, X. [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States)

    2015-01-15

    Purpose: The use of magnetic resonance imaging (MRI) in radiation oncology is expanding rapidly, and more clinics are integrating MRI into their radiation therapy workflows. However, radiation therapy presents a new set of challenges and places additional constraints on MRI compared to diagnostic radiology that, if not properly addressed, can undermine the advantages MRI offers for radiation treatment planning (RTP). The authors introduce here strategies to manage several challenges of using MRI for virtual simulation in external beam RTP. Methods: A total of 810 clinical MRI simulation exams were performed using a dedicated MRI scanner for external beam RTP of brain, breast, cervix, head and neck, liver, pancreas, prostate, and sarcoma cancers. Patients were imaged in treatment position using MRI-optimal immobilization devices. Radiofrequency (RF) coil configurations and scan protocols were optimized based on RTP constraints. Off-resonance and gradient nonlinearity-induced geometric distortions were minimized or corrected prior to using images for RTP. A multidisciplinary MRI simulation guide, along with window width and level presets, was created to standardize use of MR images during RTP. A quality assurance program was implemented to maintain accuracy and repeatability of MRI simulation exams. Results: The combination of a large bore scanner, high field strength, and circumferentially wrapped, flexible phased array RF receive coils permitted acquisition of thin slice images with high contrast-to-noise ratio (CNR) and image intensity uniformity, while simultaneously accommodating patient setup and immobilization devices. Postprocessing corrections and alternative acquisition methods were required to reduce or correct off-resonance and gradient nonlinearity induced geometric distortions. Conclusions: The methodology described herein contains practical strategies the authors have implemented through lessons learned performing clinical MRI simulation exams. In

  5. Comprehensive MRI simulation methodology using a dedicated MRI scanner in radiation oncology for external beam radiation treatment planning

    International Nuclear Information System (INIS)

    Purpose: The use of magnetic resonance imaging (MRI) in radiation oncology is expanding rapidly, and more clinics are integrating MRI into their radiation therapy workflows. However, radiation therapy presents a new set of challenges and places additional constraints on MRI compared to diagnostic radiology that, if not properly addressed, can undermine the advantages MRI offers for radiation treatment planning (RTP). The authors introduce here strategies to manage several challenges of using MRI for virtual simulation in external beam RTP. Methods: A total of 810 clinical MRI simulation exams were performed using a dedicated MRI scanner for external beam RTP of brain, breast, cervix, head and neck, liver, pancreas, prostate, and sarcoma cancers. Patients were imaged in treatment position using MRI-optimal immobilization devices. Radiofrequency (RF) coil configurations and scan protocols were optimized based on RTP constraints. Off-resonance and gradient nonlinearity-induced geometric distortions were minimized or corrected prior to using images for RTP. A multidisciplinary MRI simulation guide, along with window width and level presets, was created to standardize use of MR images during RTP. A quality assurance program was implemented to maintain accuracy and repeatability of MRI simulation exams. Results: The combination of a large bore scanner, high field strength, and circumferentially wrapped, flexible phased array RF receive coils permitted acquisition of thin slice images with high contrast-to-noise ratio (CNR) and image intensity uniformity, while simultaneously accommodating patient setup and immobilization devices. Postprocessing corrections and alternative acquisition methods were required to reduce or correct off-resonance and gradient nonlinearity induced geometric distortions. Conclusions: The methodology described herein contains practical strategies the authors have implemented through lessons learned performing clinical MRI simulation exams. In

  6. Radiation quality and ion-beam therapy: understanding the users' needs

    International Nuclear Information System (INIS)

    Ion-beam therapy faces a growing demand of tools able to map radiation quality within the irradiated volume. Although analytical computations and simulations provide useful estimations of dose and radiation quality, the direct measure of those parameters would improve ion-beam therapy in particular when deep-seated tumours are irradiated, tissue composition and density are variable or organs at risk are near the tumour. Several ion-beam therapy facilities are studying detectors and procedures for measuring the radiation quality on a microdosimetric as well as a nanodosimetric scale. Simplicity and miniaturisation of the devices are essential for measurements first in phantoms and thereafter during therapy, particularly for intra-cavity detectors. MedAustron is studying solid-state detectors based on a single crystal chemical vapour deposition diamond. In collaboration with Italian National Institute for Nuclear Physics (INFN), Tor Vergata and Legnaro; INFN-microdosimetry and track structure project; Austrian Institute of Technology, Vienna; and Italian National agency for new technologies, energy and sustainable economic development, Rome, prototypes have been developed to characterise radiation quality in sizes equivalent to one micrometre of biological tissue. (authors)

  7. Role of the rise rate of beam current in the microwave radiation of vircator

    Science.gov (United States)

    Li, Limin; Cheng, Guoxin; Zhang, Le; Ji, Xiang; Chang, Lei; Xu, Qifu; Liu, Lie; Wen, Jianchun; Li, Chuanlu; Wan, Hong

    2011-04-01

    In this paper, the effect of the rise rate of beam current on the microwave radiation of a virtual cathode oscillator (vircator) is presented. Interestingly, it was observed that the rise rate of the beam current increased as the pulse shot proceeded, which is accompanied by the decrease in microwave power. By comparing the experimental results of two cathode materials (carbon fiber and stainless steel), it was found that the above behavior is independent of the cathode materials. The ion flow, induced by the repetitive action of beam electrons with the anode grid, directly affects the development of beam current. A twice-increased process of ion flow was observed, and there are two factors involved in this process, namely, the reflection of electrons between the cathode and virtual cathode and the effect of one-time bombardment of electron beam. After the irradiation of pulsed electron beam, some microprotrusions toward the cathode appeared on the anode surface, with a quasiperiodic structure. The appearance of ion flow, as the anode plasma forms, increases the beam current and enhances the beam current density. The anode plasma is generated relatively easily as the shot test proceeds, due to the aging of anode grid, which allows the possibility of the decrease in the microwave power. As the pulse shot proceeds, the changes in the rise rate of beam current are closely related to the aging process of anode surface. Therefore, the further enhancement of vircator efficiency needs to lengthen the lifetime of anode, besides the optimization of explosive emission cathodes.

  8. Irradiation of 135 MeV/u carbon and neon beams for studies of radiation biology

    International Nuclear Information System (INIS)

    A heavy ion irradiation system was designed and constructed at RIKEN ring cyclotron facility for studies of radiation physics and radiation biology. Carbon and neon beams of 135 MeV/u were firstly used for the experiments. A pair of wobbler magnets and a scatterer were used for obtaining the uniform radiation field of about 10 cm in diameter. A parallel plate ionization chamber was used for dose monitoring. A range shifter was used for degrading the initial energy of the heavy ions. Precise depth dose distributions were measured by a small parallel plate ionization chamber and a variable length water column. LET (linear energy transfer) of the heavy ion radiation fields were measured by a parallel plate proportional chamber. From these basic measurements, biological experiments using these heavy ions are now carried out at this facility. (author)

  9. An examination of human factors in external beam radiation therapy: Findings and implications

    International Nuclear Information System (INIS)

    To better understand the contributing factors to human error in external beam radiation therapy, the US Nuclear Regulatory Commission has undertaken a series of human factors evaluations. A team of human factors specialists, assisted by a panel of radiation oncologists, medical physicists, and radiation technologists, conducted visits to 24 radiation oncology departments at community hospitals, university centers, and free-standing clinics. A function and task analysis was initially performed to guide subsequent evaluations in the areas of human-system interfaces, procedures, training and qualifications, and organizational policies and practices. Representative findings and implications for improvement are discussed within the context of a dynamic model which holds that misadministration likely results from the unanticipated interaction of several necessary but singly insufficient conditions

  10. CMS Run-2 Instrumentation for beam radiation and luminosity measurement using novel detector technologies

    Science.gov (United States)

    Gomez Espinosa, Alejandro; CMS Collaboration Collaboration

    2016-03-01

    The higher energy and luminosity for Run 2 at the LHC initiated the development of dedicated technologies for beam radiation monitoring and luminosity measurement. A dedicated pixel luminosity detector measures coincidences in several three layer telescopes of silicon pixel detectors to arrive at a luminosity for each colliding LHC bunch pair. The full pixel data is also read out at a lower rate to reconstruct charged particle tracks for monitoring and beam spot determination. The upgraded fast beam conditions monitor measures the particle flux using 24 two pad single crystalline diamond sensors, equipped with a fast front-end ASIC, produced in 130 nm CMOS technology, for excellent time resolution. A new beam-halo monitor exploits Cerenkov light production in fused quartz crystals to provide direction sensitivity and excellent time resolution to separate incoming and outgoing particles. The back-end electronics of the beam monitoring systems include dedicated modules with high bandwidth digitizers developed in both VME and microTCA standards for per bunch beam measurements and gain monitoring. All sub-detectors have been taking data from the first day of LHC operation in April 2015. Detector performance results from the 2015 LHC Run II will be presented.

  11. Synchrotron radiation and beam tube vacuum in a Very Large Hadron Collider, Stage 1 and Stage 2 VLHC

    International Nuclear Information System (INIS)

    Synchrotron radiation induced photodesorption in particle accelerators may lead to pressure rise and to beam-gas scattering losses, finally affecting the beam lifetime [1]. We discuss the beam tube vacuum in the low field Stage 1 and Stage 2 Very Large Hadron Collider VLHC. Since VLHC Stage 1 has a room temperature beam tube, a non-evaporable getter (NEG St101 strip) pumping system located inside a pumping antechamber, supplemented by lumped ion pumps for pumping methane is considered. In Stage 2, the ∼100 K beam screen, or liner, illuminated by the synchrotron radiation, is inserted into the magnet cold bore. Cryo-pumping is provided by the cold bore kept at 4.2 K, through slots covering the beam screen surface. Possible beam conditioning scenarios are presented for reaching design intensity, both for Stage 1 and 2. The most important results are summarized in this paper

  12. A Novel Approach to Beam Steering Using Arrays Composed of Multiple Unique Radiating Modes

    Science.gov (United States)

    Labadie, Nathan Richard

    Phased array antennas have found wide application in both radar and wireless communications systems particularly as implementation costs continue to decrease. The primary advantages of electronically scanned arrays are speed of beam scan and versatility of beamforming compared to mechanically scanned fixed beam antennas. These benefits come at the cost of a few well known design issues including element pattern rolloff and mutual coupling between elements. Our primary contribution to the field of research is the demonstration of significant improvement in phased array scan performance using multiple unique radiating modes. In short, orthogonal radiating modes have minimal coupling by definition and can also be generated with reduced rolloff at wide scan angles. In this dissertation, we present a combination of analysis, full-wave electromagnetic simulation and measured data to support our claims. The novel folded ring resonator (FRR) antenna is introduced as a wideband and multi-band element embedded in a grounded dielectric substrate. Multiple radiating modes of a small ground plane excited by a four element FRR array were also investigated. A novel hemispherical null steering antenna composed of two collocated radiating elements, each supporting a unique radiating mode, is presented in the context of an anti-jam GPS receiver application. Both the antenna aperture and active feed network were fabricated and measured showing excellent agreement with analytical and simulated data. The concept of using an antenna supporting multiple radiating modes for beam steering is also explored. A 16 element hybrid linear phased array was fabricated and measured demonstrating significantly improved scan range and scanned gain compared to a conventional phased array. This idea is expanded to 2 dimensional scanning arrays by analysis and simulation of a hybrid phased array composed of novel multiple mode monopole on patch antenna sub-arrays. Finally, we fabricated and

  13. External-beam radiation therapy after surgical resection and intraoperative electron-beam radiation therapy for oligorecurrent gynecological cancer. Long-term outcome

    Energy Technology Data Exchange (ETDEWEB)

    Sole, C.V. [Hospital General Universitario Gregorio Maranon, Department of Oncology, Madrid (Spain); Complutense University, School of Medicine, Madrid (Spain); Instituto de Radiomedicina, Service of Radiation Oncology, Santiago (Chile); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Calvo, F.A. [Hospital General Universitario Gregorio Maranon, Department of Oncology, Madrid (Spain); Complutense University, School of Medicine, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Lozano, M.A.; Gonzalez-Sansegundo, C. [Hospital General Universitario Gregorio Maranon, Department of Oncology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Service of Radiation Oncology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Gonzalez-Bayon, L. [Hospital General Universitario Gregorio Maranon, Service of General Surgery, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Alvarez, A. [Hospital General Universitario Gregorio Maranon, Service of Radiation Oncology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Lizarraga, S. [Hospital General Universitario Gregorio Maranon, Department of Gynecology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute of Research Investigation, Madrid (Spain); Garcia-Sabrido, J.L. [Complutense University, School of Medicine, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Service of General Surgery, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Department of Gynecology, Madrid (Spain)

    2014-02-15

    The goal of the present study was to analyze prognostic factors in patients treated with external-beam radiation therapy (EBRT), surgical resection and intraoperative electron-beam radiotherapy (IOERT) for oligorecurrent gynecological cancer (ORGC). From January 1995 to December 2012, 61 patients with ORGC [uterine cervix (52 %), endometrial (30 %), ovarian (15 %), vagina (3 %)] underwent IOERT (12.5 Gy, range 10-15 Gy), and surgical resection to the pelvic (57 %) and paraaortic (43 %) recurrence tumor bed. In addition, 29 patients (48 %) also received EBRT (range 30.6-50.4 Gy). Survival outcomes were estimated using the Kaplan-Meier method, and risk factors were identified by univariate and multivariate analyses. Median follow-up time for the entire cohort of patients was 42 months (range 2-169 months). The 10-year rates for overall survival (OS) and locoregional control (LRC) were 17 and 65 %, respectively. On multivariate analysis, no tumor fragmentation (HR 0.22; p = 0.03), time interval from primary tumor diagnosis to locoregional recurrence (LRR) < 24 months (HR 4.02; p = 0.02) and no EBRT at the time of pelvic recurrence (HR 3.95; p = 0.02) retained significance with regard to LRR. Time interval from primary tumor to LRR < 24 months (HR 2.32; p = 0.02) and no EBRT at the time of pelvic recurrence (HR 3.77; p = 0.04) showed a significant association with OS after adjustment for other covariates. External-beam radiation therapy at the time of pelvic recurrence, time interval for relapse ≥24 months and not multi-involved fragmented resection specimens are associated with improved LRC in patients with ORGC. As suggested from the present analysis a significant group of ORGC patients could potentially benefit from multimodality rescue treatment. (orig.)

  14. External-beam radiation therapy after surgical resection and intraoperative electron-beam radiation therapy for oligorecurrent gynecological cancer. Long-term outcome

    International Nuclear Information System (INIS)

    The goal of the present study was to analyze prognostic factors in patients treated with external-beam radiation therapy (EBRT), surgical resection and intraoperative electron-beam radiotherapy (IOERT) for oligorecurrent gynecological cancer (ORGC). From January 1995 to December 2012, 61 patients with ORGC [uterine cervix (52 %), endometrial (30 %), ovarian (15 %), vagina (3 %)] underwent IOERT (12.5 Gy, range 10-15 Gy), and surgical resection to the pelvic (57 %) and paraaortic (43 %) recurrence tumor bed. In addition, 29 patients (48 %) also received EBRT (range 30.6-50.4 Gy). Survival outcomes were estimated using the Kaplan-Meier method, and risk factors were identified by univariate and multivariate analyses. Median follow-up time for the entire cohort of patients was 42 months (range 2-169 months). The 10-year rates for overall survival (OS) and locoregional control (LRC) were 17 and 65 %, respectively. On multivariate analysis, no tumor fragmentation (HR 0.22; p = 0.03), time interval from primary tumor diagnosis to locoregional recurrence (LRR) < 24 months (HR 4.02; p = 0.02) and no EBRT at the time of pelvic recurrence (HR 3.95; p = 0.02) retained significance with regard to LRR. Time interval from primary tumor to LRR < 24 months (HR 2.32; p = 0.02) and no EBRT at the time of pelvic recurrence (HR 3.77; p = 0.04) showed a significant association with OS after adjustment for other covariates. External-beam radiation therapy at the time of pelvic recurrence, time interval for relapse ≥24 months and not multi-involved fragmented resection specimens are associated with improved LRC in patients with ORGC. As suggested from the present analysis a significant group of ORGC patients could potentially benefit from multimodality rescue treatment. (orig.)

  15. Radiation Therapy of Large Intact Breasts Using a Beam Spoiler or Photons with Mixed Energies

    International Nuclear Information System (INIS)

    Radiation treatment of large intact breasts with separations of more than 24 cm is typically performed using x-rays with energies of 10 MV and higher, to eliminate high-dose regions in tissue. The disadvantage of the higher energy beams is the reduced dose to superficial tissue in the buildup region. We evaluated 2 methods of avoiding this underdosage: (1) a beam spoiler: 1.7-cm-thick Lucite plate positioned in the blocking tray 35 cm from the isocenter, with 15-MV x-rays; and (2) combining 6- and 15-MV x-rays through the same portal. For the beam with the spoiler, we measured the dose distribution for normal and oblique incidence using a film and ion chamber in polystyrene, as well as a scanning diode in a water tank. In the mixed-energy approach, we calculated the dose distributions in the buildup region for different proportions of 6- and 15-MV beams. The dose enhancement due to the beam spoiler exhibited significant dependence upon the source-to-skin distance (SSD), field size, and the angle of incidence. In the center of a 20 x 20-cm2 field at 90-cm SSD, the beam spoiler raises the dose at 5-mm depth from 77% to 87% of the prescription, while maintaining the skin dose below 57%. Comparison of calculated dose with measurements suggested a practical way of treatment planning with the spoiler-usage of 2-mm 'beam' bolus-a special option offered by in-house treatment planning system. A second method of increasing buildup doses is to mix 6- and 15-MV beams. For example, in the case of a parallel-opposed irradiation of a 27-cm-thick phantom, dose to Dmax for each energy, with respect to midplane, is 114% for pure 6-, 107% for 15-MV beam with the spoiler, and 108% for a 3:1 mixture of 15- and 6-MV beams. Both methods are practical for radiation therapy of large intact breasts

  16. Control of Coherent Synchrotron Radiation and Micro-Bunching Effects During Transport of High Brightness Electron Beams

    CERN Document Server

    Douglas, D R; Hutton, A; Krafft, G A; Li, R; Neil, G R; Roblin, Y; Tennant, C D; Tsai, C -Y

    2014-01-01

    Beam quality preservation during transport of high-brightness electron beams is of general concern in the design of modern accelerators. Methods to manage incoherent synchrotron radiation (ISR) have been in place for decades; as beam brightness has improved coherent synchrotron radiation (CSR) and the microbunching instability (uBI) have emerged as performance limitations. We apply the compensation analysis of diMitri, Cornacchia, and Spampinati - as previously used by Borland - to the design of transport systems for use with low-emittance beams, and find that appropriately configured second order achromats will suppress transverse emittance growth due to CSR and appear to limit uBI gain.

  17. Beam-induced radiation in the compact muon solenoid tracker at the Large Hadron Collider

    Indian Academy of Sciences (India)

    A P Singh; P C Bhat; N V Mokhov; S Beri

    2010-05-01

    The intense radiation environment at the Large Hadron Collider, CERN at a design energy of $\\sqrt{s} = 14$ TeV and a luminosity of 1034 cm−2S−1 poses unprecedented challenges for safe operation and performance quality of the silicon tracker detectors in the CMS and ATLAS experiments. The silicon trackers are crucial for the physics at the LHC experiments, and the inner layers, being situated only a few centimeters from the interaction point, are most vulnerable to beam-induced radiation. We have recently carried out extensive Monte Carlo simulation studies using MARS program to estimate particle fluxes and radiation dose in the CMS silicon pixel and strip trackers from proton–proton collisions at $\\sqrt{s} = 14$ TeV and from machine-induced background such as beam–gas interactions and beam halo. We will present results on radiation dose, particle fluxes and spectra from these studies and discuss implications for radiation damage and performance of the CMS silicon tracker detectors.

  18. Palliative treatment of advanced cancer using multiple nonconfluent pencil beam radiation. A pilot study

    International Nuclear Information System (INIS)

    In the era of orthovoltage radiation, multiple nonconfluent pencil beam radiation (GRID) therapy was utilized to minimize superficial normal tissue damage while delivering tumorcidal doses at specified depths in tissues. The success of GRID therapy was based on the fact that small volumes of tissues could tolerate high doses of radiation. Since the development of megavoltage radiation and skin sparing, GRID therapy has been abandoned. In a pilot study, the authors adapted the principles of GRID therapy to megavoltage photon beams to treat patients with massive tumors or recurrent tumors after tolerance doses of radiation. Twenty-two patients have been entered in the study. All patients were symptomatic and had exhaustive conventional surgery, chemotherapy, and radiotherapy approaches to treatment. A 50:50 GRID (open to closed areas) was utilized, and a prescribed dose of 1000 to 1500 cGy to the open areas was given using a single photon field. In four patients, a second GRID treated was delivered at a split course interval of 4 weeks. The follow-up in these patients ranges from 1 month to 18 months. The results of treatment have been remarkable with 20 of 22 patients achieving dramatic relief of severe symptoms, and several patients showing significant objective regression. No acute effects have been observed, including those patients having large volumes of the abdomen irradiated. No unusual skin or subcutaneous early or late damage has been observed in follow-up

  19. Protective effect of allium sativum ethanol extract on cultured human lymphocytes against electron beam radiation

    International Nuclear Information System (INIS)

    The development of radioprotective agent has been the subject of intense research because exposure to ionizing radiation causes DNA damage which may cause mutation and ultimately leads to cancer, on the other hand radiotherapy has become an integral part in treatment of cancer which uses ionizing radiations like X rays, gamma rays to kill the cancer cells. Amifostine is a well-known radioprotector which is clinically approved. There are many other radioprotectors like cysteine, cystamine, serotine but they are not used because of its normal tissue toxicity. Allium sativum is commonly known as garlic which has already been reported for its medicinal properties. In this study we evaluated radioprotection property of Allium sativum on DNA damage caused by electron beam radiation in cultured human lymphocytes. Allium sativum ethanol extract was used for this study. Cell viability was performed by MTT assay. DNA damage was assessed by comet assay parameters. The cultured lymphocytes were incubated with different concentrations 10, 50 and 100 μg/mL of Allium sativum extracts for 2, 4, 6 and 24 hour time intervals. Treatment of lymphocytes with various concentration of Allium sativum extract resulted in significant decrease in the level of DNA damage (Percentage tail DNA 6%) and increase in cell viability 93% (p>0.05) compare to the radiation control group. Results of this study revealed that Allium sativum protects cultured lymphocytes when exposed to electron beam radiation at its sub lethal dose. (author)

  20. Ion-beam simulation of radiation damage produced by fast neutrons in heterophase structures

    Energy Technology Data Exchange (ETDEWEB)

    Tetelbaum, D.I., E-mail: tetelbaum@phys.unn.ru [Lobachevsky State University of Nizhny Novgorod, 23/3 Gagarin prospect, Nizhny Novgorod, 603950 (Russian Federation); Guseinov, D.V.; Vasiliev, V.K.; Mikhaylov, A.N.; Belov, A.I.; Korolev, D.S.; Obolensky, S.V. [Lobachevsky State University of Nizhny Novgorod, 23/3 Gagarin prospect, Nizhny Novgorod, 603950 (Russian Federation); Kachemtsev, A.N. [Sedakov Scientific-Research Institute, GSP-486, Nizhny Novgorod 603950 (Russian Federation)

    2014-05-01

    3D Monte-Carlo algorithm and computer code have been developed that allows choosing and optimizing the conditions of ion irradiation needed for the adequate ion-beam simulation of radiation damage under fast neutron irradiation. It is established that, by the proper selection of energy and dose of Si{sup +} ions, it is possible to reproduce well the effect of irradiation with fission neutrons of subsurface and buried layers of silicon or Si-based 2D and 3D-heterostructures. The results can be used for testing the radiation hardness of silicon-based electronic and optoelectronic device structures.

  1. Modelling radiation fields of ion beams in tissue-like materials

    International Nuclear Information System (INIS)

    Fast nuclei are ionizing radiation which can cause deleterious effects to irradiated cells. The modelling of the interactions of such ions with matter and the related effects are very important to physics, radiobiology, medicine and space science and technology. A powerful method to study the interactions of ionizing radiation with biological systems was developed in the field of microdosimetry. Microdosimetry spectra characterize the energy deposition to objects of cellular size, i.e., a few micrometers. In the present thesis the interaction of ions with tissue-like media was investigated using the Monte Carlo model for Heavy-Ion Therapy (MCHIT) developed at the Frankfurt Institute for Advanced Studies. MCHIT is a Geant4-based application intended to benchmark the physical models of Geant4 and investigate the physical properties of therapeutic ion beams. We have implemented new features in MCHIT in order to calculate microdosimetric quantities characterizing the radiation fields of accelerated nucleons and nuclei. The results of our Monte Carlo simulations were compared with recent experimental microdosimetry data. In addition to microdosimetry calculations with MCHIT, we also investigated the biological properties of ion beams, e.g. their relative biological effectiveness (RBE), by means of the modified Microdosimetric-Kinetic model (MKM). The MKM uses microdosimetry spectra in describing cell response to radiation. MCHIT+MKM allowed us to study the physical and biological properties of ion beams. The main results of the thesis are as follows: MCHIT is able to describe the spatial distribution of the physical dose in tissue-like media and microdosimetry spectra for ions with energies relevant to space research and ion-beam cancer therapy; MCHIT+MKM predicts a reduction of the biological effectiveness of ions propagating in extended medium due to nuclear fragmentation reactions; We predicted favourable biological dose-depth profiles for monoenergetic helium and

  2. Small Radiation Beam Dosimetry for Radiosurgery of Trigeminal Neuralgia: One Case Analysis

    Science.gov (United States)

    García-Garduño, O. A.; Lárraga-Gutiérrez, J. M.; Rodríguez-Villafuerte, M.; Martínez-Dávalos, A.; Moreno-Jiménez, S.; Suárez-Campos, J. J.; Celis, M. A.

    2008-08-01

    The use of small radiation beams for trigeminal neuralgia (TN) treatment requires high precision and accuracy in dose distribution calculations and delivery. Special attention must be kept on the type of detector to be used. In this work, the use of GafChromic EBT® radiochromic and X-OMAT V2 radiographic films for small radiation beam characterization is reported. The dosimetric information provided by the films (total output factors, tissue maximum ratios and off axis ratios) is compared against measurements with a shielded solid state (diode) reference detector. The film dosimetry was used for dose distribution calculations for the treatment of trigeminal neuralgia radiosurgery. Comparison of the isodose curves shows that the dosimetry produced with the X-OMAT radiographic film overestimates the dose distributions in the penumbra region.

  3. Small Radiation Beam Dosimetry for Radiosurgery of Trigeminal Neuralgia: One Case Analysis

    International Nuclear Information System (INIS)

    The use of small radiation beams for trigeminal neuralgia (TN) treatment requires high precision and accuracy in dose distribution calculations and delivery. Special attention must be kept on the type of detector to be used. In this work, the use of GafChromic EBT registered radiochromic and X-OMAT V2 radiographic films for small radiation beam characterization is reported. The dosimetric information provided by the films (total output factors, tissue maximum ratios and off axis ratios) is compared against measurements with a shielded solid state (diode) reference detector. The film dosimetry was used for dose distribution calculations for the treatment of trigeminal neuralgia radiosurgery. Comparison of the isodose curves shows that the dosimetry produced with the X-OMAT radiographic film overestimates the dose distributions in the penumbra region

  4. In vivo pink-beam imaging and fast alignment procedure for rat brain tumor radiation therapy.

    Science.gov (United States)

    Nemoz, Christian; Kibleur, Astrid; Hyacinthe, Jean Noël; Berruyer, Gilles; Brochard, Thierry; Bräuer-Krisch, Elke; Le Duc, Géraldine; Brun, Emmanuel; Elleaume, Hélène; Serduc, Raphaël

    2016-01-01

    A fast positioning method for brain tumor microbeam irradiations for preclinical studies at third-generation X-ray sources is described. The three-dimensional alignment of the animals relative to the X-ray beam was based on the X-ray tomography multi-slices after iodine infusion. This method used pink-beam imaging produced by the ID17 wiggler. A graphical user interface has been developed in order to define the irradiation parameters: field width, height, number of angles and X-ray dose. This study is the first reporting an image guided method for soft tissue synchrotron radiotherapy. It allowed microbeam radiation therapy irradiation fields to be reduced by a factor of ∼20 compared with previous studies. It permitted more targeted, more efficient brain tumor microbeam treatments and reduces normal brain toxicity of the radiation treatment. PMID:26698083

  5. Coherent transition radiation-based diagnosis of electron beam pulse shape

    International Nuclear Information System (INIS)

    The bunch shapes of an electron beams is increasingly difficult to measure, as the time-scales of interest are now sub-picosecond. We discuss here the use of coherent transition radiation CTR for such measurements. Two types of measurements are presented: the deduction of macroscopic (0.3 psec resolution) pulse profile using interferometry, and the examination of microbunch (50 fsec) structure from an FEL-bunched beam using spectral characteristics of the CTR. For the macrobunch measurement we discuss the problem of missing low frequency radiation and one solution for extracting meaningful data with this problem present. For microbunch CTR, we examing initial spectrally resolved measurements, and some interesting deviations in the CTR spectrum from the standard theoretical predictions. copyright 1999 American Institute of Physics

  6. Synergy effect of radiation damage on 12Cr-ODS steel by multi-ion-beams

    International Nuclear Information System (INIS)

    In this work, 12Cr-ODS steel samples were irradiated by different combinations of Si, He and H ion beams at room temperature. Mechanical property measurements of the irradiated samples showed that all the samples exhibited irradiation swelling and hardening,but the sample co-irradiated by three ion beams had the biggest swelling and smallest hardening. Combining on the TEM imaging,analyses of irradiation changes of 12Cr-ODS steel samples were carried out. Raman spectra of the irradiated samples revealed carbon precipitated inside the samples, and carbon peak distribution could reflect the radiation damage distribution. The results, which accumulated experimental data and clarified the radiation damage to nuclear materials by synergy effect, are of help for application of 12Cr-ODS steel in an advanced reactor. (authors)

  7. Processing researches on radiation vulcanization of natural rubber latex with low energy electron beam machine

    International Nuclear Information System (INIS)

    Processing researches on radiation vulcanization of natural rubber latex (RVNRL) was carried out with low energy electron beam machine, and explored the impact of RVNRL in a variety of factors. The results showed: It was beneficial to manufacture with increasing the dry rubber content of latex and increasing beam current. It was important to increase strength of RVNRL film using natural latex with higher green strength. Added to 0.5-1.5 phr (parts per hundreds of rubber) of PVA (polyvinyl alcohol) in radiation vulcanized latex, then the centrifugal method can greatly remove the water-soluble proteins, so that the residual water-soluble proteins in films or products can be reduced to acceptable levels. (authors)

  8. Radiation exposure in a modern, circularly scanned-beam laminographic X-ray inspection system.

    Science.gov (United States)

    Fazzio, R S

    1998-01-01

    Circularly scanned-beam laminography is currently the predominant technique used for the nondestructive examination of printed circuit solder assemblies via cross-sectional X-ray imaging. Given industry trends towards double-sided assemblies and limited access components, cross-sectional X-ray inspection is furthermore becoming increasingly important. Use of X-rays for inspection of solder joints on loaded printed circuit boards nonetheless often leads to concern surrounding possible undesirable radiation effects on the circuitry mounted on the board. In this paper we develop a simple analytical model useful for predicting the radiation exposure rates in a scanned-beam laminography system. We demonstrate the validity of the model through a series of dosimetry experiments. PMID:22388470

  9. External beam radiation therapy and retinoblastoma: Long-term results in the comparison of two techniques

    International Nuclear Information System (INIS)

    Purpose: This study compares the long-term actuarial local control, eye conservation rate, survival, and ocular complications in children with retinoblastoma treated with two different external beam treatment techniques. Methods and Materials: From 1979-1991, 182 eyes in 123 children (104 bilateral) received primary external beam radiation therapy. An anterior lens-sparing electron beam technique delivering 38 to 50 Gy in 2.5 Gy fractions was used in 67 eyes from 1979-1984 and a modified lateral beam technique, delivering 42 to 46 Gy in 2 Gy fractions, was used in 113 eyes from 1984-1991. These groups were balanced with respect to known prognostic variables. Results: For Group I-III eyes, the 5- and 8-year local control was significantly improved using the modified lateral beam technique (84%) compared to (38%) using the anterior lens sparing technique (p p ≤ 0.0001). For Group IV-V eyes, the 5- and 8-year local control rates were not statistically different, despite a trend favoring the modified lateral beam technique. Survival endpoints including eye survival (no enucleation), cause-specific survival, and overall survival comparing the two treatment techniques were not significantly different. Overall, 22% of eyes developed cataracts. There was no difference between the two treatment groups in terms of cataract development. No eyes required enucleation for ocular complications. Conclusion: There is a significant improvement in local control using the modified lateral beam technique compared to an anterior lens-sparing approach for Group I-III eyes. However, there was no difference in survival end points between the two treatment techniques. The incidence of ocular complications using these two external beam techniques is acceptable.

  10. Radiation hygienization of cattle and swine slurry with high energy electron beam

    International Nuclear Information System (INIS)

    The research was carried out to assess the efficiency of radiation hygienization of cattle and swine slurry of different density using the high energy electron beam based on the inactivation rate of Salmonella ssp, Escherichia coli, Enterococcus spp and Ascaris suum eggs. The experiment was conducted with use of the linear electron accelerator Elektronika 10/10 in Institute of Nuclear Chemistry and Technology in Warsaw. The inoculated slurry samples underwent hygienization with high energy electron beam of 1, 3, 5, 7 and 10 kGy. Numbers of reisolated bacteria were determined according to the MPN method, using typical microbiological media. Theoretical lethal doses, D90 doses and hygienization efficiency of high energy electron beam were determined. The theoretical lethal doses for all tested bacteria ranged from 3.63 to 8.84 kGy and for A. suum eggs from 4.07 to 5.83 kGy. Salmonella rods turned out to be the most sensitive and Enterococcus spp were the most resistant to electron beam hygienization. The effectiveness or radiation hygienization was lower in cattle than in swine slurry and in thick than in thin one. Also the species or even the serotype of bacteria determined the dose needed to inactivation of microorganisms. - Highlights: ► The hygienic efficiency of electron beam against slurry was researched. ► The hygienization efficiency depended on the slurry characteristics and microorganism species. ► In most of the cases 7 kGy dose was sufficient for slurry hygienization. ► Dose below 1 kGy allowed for 90% elimination of microorganism population. ► The radiation hygienization is a good alternative for typical slurry treatment methods

  11. System for detecting neutrons in the harsh radiation environment of a relativistic electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Kruse, L.W.

    1978-06-01

    Newly developed detectors and procedures allow measurement of neutron yield and energy in the harsh radiation environment of a relativistic electron beam source. A new photomultiplier tube design and special gating methods provide the basis for novel time-of-flight and total-yield detectors. The technique of activation analysis is expanded to provide a neutron energy spectrometer. There is a demonstrated potential in the use of the integrated system as a valuable diagnostic tool to study particle-beam fusion, intense ion-beam interactions, and pulsed neutron sources for simulating weapons effects. A physical lower limit of 10/sup 8/ neutrons into 4..pi.. is established for accurate and meaningful measurements in the REB environment.

  12. System for detecting neutrons in the harsh radiation environment of a relativistic electron beam

    International Nuclear Information System (INIS)

    Newly developed detectors and procedures allow measurement of neutron yield and energy in the harsh radiation environment of a relativistic electron beam source. A new photomultiplier tube design and special gating methods provide the basis for novel time-of-flight and total-yield detectors. The technique of activation analysis is expanded to provide a neutron energy spectrometer. There is a demonstrated potential in the use of the integrated system as a valuable diagnostic tool to study particle-beam fusion, intense ion-beam interactions, and pulsed neutron sources for simulating weapons effects. A physical lower limit of 108 neutrons into 4π is established for accurate and meaningful measurements in the REB environment

  13. Cerenkov light spectrum in an optical fiber exposed to a photon or electron radiation therapy beam

    International Nuclear Information System (INIS)

    A Cerenkov signal is generated when energetic charged particles enter the core of an optical fiber. The Cerenkov intensity can be large enough to interfere with signals transmitted through the fiber. We determine the spectrum of the Cerenkov background signal generated in a poly(methyl methacrylate) optical fiber exposed to photon and electron therapeutic beams from a linear accelerator. This spectral measurement is relevant to discrimination of the signal from the background, as in scintillation dosimetry using optical fiber readouts. We find that the spectrum is approximated by the theoretical curve after correction for the wavelength dependent attenuation of the fiber. The spectrum does not depend significantly on the angle between the radiation beam and the axis of the fiber optic but is dependent on the depth in water at which the fiber is exposed to the beam.

  14. Instrumentation for beam radiation and luminosity measurement in the CMS experiment using novel detector technologies

    CERN Document Server

    Guthoff, Moritz

    2016-01-01

    The higher energy and luminosity of the LHC initiated the development of dedicated technologies for radiation monitoring and luminosity measurement. A pixelated luminosity detector counts coincidences in several three layer telescopes of silicon pixel detectors to measure the luminosity for each colliding LHC bunch pair. In addition, charged particle tracking allows to monitor the location of the collision point.The upgraded fast beam conditions monitor measures the particle flux using 24 two pad single crystalline diamond sensors, equipped with a fast front-end ASIC produced in 130 nm CMOS technology. The excellent time resolution is used to separate collision products from machine induced background.A new beam-halo monitor at larger radius exploits Cerenkov light produced by relativistic charged particles in fused quartz crystals to provide direction sensitivity and time resolution to separate incoming and outgoing particles. The back-end electronics of the beam monitoring systems includes dedicated modules...

  15. T2-weighted endorectal magnetic resonance imaging of prostate cancer after external beam radiation therapy

    Directory of Open Access Journals (Sweden)

    Antonio C. Westphalen

    2009-04-01

    Full Text Available PURPOSE: To retrospectively determine the accuracy of T2-weighted endorectal MR imaging in the detection of prostate cancer after external beam radiation therapy and to investigate the relationship between imaging accuracy and time since therapy. MATERIAL AND METHODS: Institutional review board approval was obtained and the study was HIPPA compliant. We identified 59 patients who underwent 1.5 Tesla endorectal MR imaging of the prostate between 1999 and 2006 after definitive external beam radiation therapy for biopsy-proven prostate cancer. Two readers recorded the presence or absence of tumor on T2-weighted images. Logistic regression and Fisher’s exact tests for 2x2 tables were used to determine the accuracy of imaging and investigate if accuracy differed between those imaged within 3 years of therapy (n = 25 and those imaged more than 3 years after therapy (n = 34. Transrectal biopsy was used as the standard of reference for the presence or absence of recurrent cancer. RESULTS: Thirty-four of 59 patients (58% had recurrent prostate cancer detected on biopsy. The overall accuracy of T2-weighted MR imaging in the detection cancer after external beam radiation therapy was 63% (37/59 for reader 1 and 71% for reader 2 (42/59. For both readers, logistic regression showed no difference in accuracy between those imaged within 3 years of therapy and those imaged more than 3 years after therapy (p = 0.86 for reader 1 and 0.44 for reader 2. CONCLUSION: T2-weighted endorectal MR imaging has low accuracy in the detection of prostate cancer after external beam radiation therapy, irrespective of the time since therapy.

  16. Radiation effects in LiB3O5 nonlinear crystals under eletron beam irradiation

    International Nuclear Information System (INIS)

    Investigation results on defect accumulation in LiB3O5 crystals under electron beam irradiation are presented. A conclusion has been made about the role of radiation-induced defects in the accumulation of electric charges in LBO crystals under destructive electron irradiation due to electric breakdown. The processes considered can simulate defect formation in a crystaltransformer based on LBO affected by powerful laser pulses

  17. Exercise for laboratory comparison of calibration coefficient in 137Cs beam, radiation protection - 2013/2014

    International Nuclear Information System (INIS)

    This work deals with the preliminary results of the second exercise of comparing the radiation monitors calibration laboratories in Brazil. The exercise involved eight laboratories and the measured quantity is the air kerma in a beam of 137Cs for radioprotection. The exercise was conducted by the LNMRI/IRD, in a star shaped arrangement from October 2013 to July 2015. The largest deviation was 2% of the calibration coefficient that is acceptable for applications in radioprotection. (author)

  18. A novel method for sub-micrometer transverse electron beam size measurements using optical transition radiation

    OpenAIRE

    Aryshev, A.; Boogert, S. T.; Howell, D.; Karataev, P.; Terunuma, N.; Urakawa, J.

    2010-01-01

    Optical Transition Radiation (OTR) appearing when a charged particle crosses a boundary between two media with different dielectric properties has widely been used as a tool for transverse profile measurements of charged particle beams in various facilities worldwide. The resolution of the monitor is defined by so-called Point Spread Function (PSF), source distribution generated by a single electron and projected by an optical system onto a screen. In this paper we represent the development o...

  19. Beam plug replacement and alignment under high radiation conditions for cold neutron facilities at Hanaro

    International Nuclear Information System (INIS)

    Full text : The HANARO, an open-tank-in-pool type research reactor of a 30 MWth power in Korea, has been operating for 15 years since its initial criticality in February 1995. The beam port assigned for the cold neutron at HANARO had been used for an 8-m SANS without neutron guides until it was replaced by a cold neutron guide system in 2008. It was developed a cold neutron guide system for the delivery of cold neutrons from the cold neutron source in the reactor to the neutron scattering instruments in the guide hall. Since the HANARO has been operated from 1995, it was a big challenge to replace the existing plug and shutter with the new facilities under high radiation conditions. When the old plug was removed from the beam port in 2008, the radiation level was 230 mSv/hr at the end of beam port. In addition to that, there were more difficult situations such as the poor as-built dimensions of the beam port, limited work space and time constraint due to other constructions in parallel in the reactor hall. Before the removal of the old plug the level of the radiation was measured coming out through a small hole of the plug to estimate the radiation level during the removal of the old plug and installation of a new plug. Based on the measurement and analysis results, special tools and various shielding facilities were developed for the removal of old in-pile plug and the installation of the new in-pile plug assembly safely. In 2008, the old plug and shutter were successfully replaced by the new plug and shutter as shown in this article with a minimum exposure to the workers. A laser tracker system was also one of the main factors in our successful installation and alignment under high radiation conditions and limited work space. The laser tracker was used to measure and align all the mechanical facilities and the neutron guides with a minimum radiation exposure to workers. The alignment of all the guides and accessories were possible during reactor operation because

  20. Laser-Driven Very High Energy Electron/Photon Beam Radiation Therapy in Conjunction with a Robotic System

    Directory of Open Access Journals (Sweden)

    Kazuhisa Nakajima

    2014-12-01

    Full Text Available We present a new external-beam radiation therapy system using very-high-energy (VHE electron/photon beams generated by a centimeter-scale laser plasma accelerator built in a robotic system. Most types of external-beam radiation therapy are delivered using a machine called a medical linear accelerator driven by radio frequency (RF power amplifiers, producing electron beams with an energy range of 6–20 MeV, in conjunction with modern radiation therapy technologies for effective shaping of three-dimensional dose distributions and spatially accurate dose delivery with imaging verification. However, the limited penetration depth and low quality of the transverse penumbra at such electron beams delivered from the present RF linear accelerators prevent the implementation of advanced modalities in current cancer treatments. These drawbacks can be overcome if the electron energy is increased to above 50 MeV. To overcome the disadvantages of the present RF-based medical accelerators, harnessing recent advancement of laser-driven plasma accelerators capable of producing 1-GeV electron beams in a 1-cm gas cell, we propose a new embodiment of the external-beam radiation therapy robotic system delivering very high-energy electron/photon beams with an energy of 50–250 MeV; it is more compact, less expensive, and has a simpler operation and higher performance in comparison with the current radiation therapy system.

  1. Radiation therapy for retinoblastoma: comparison of results with lens-sparing versus lateral beam techniques

    International Nuclear Information System (INIS)

    From 1979 through 1986, 170 children were seen at our institution diagnosed with retinoblastoma. Sixty-six of the children with involvement of 121 eyes, were referred for definitive external beam radiation to one or both eyes. During the study period, two distinct radiation techniques were used. From 1980 through mid-1984, a lens-sparing technique included an anterior electron beam with a contact lens mounted lead shield, combined with a lateral field, was used. Since mid-1984, a modified lateral beam technique has been used, mixing lateral electrons and superior and inferior lateral oblique split beam wedged photons. Doses prescribed were similar for both techniques, ranging from 3,850 to 5,000 cGy in 4 to 5 weeks. The lens-sparing and the modified lateral techniques are compared for local control. For eyes with Group I through III disease, the lens-sparing technique resulted in local control in 33% of the eyes treated, where the modified lateral technique controlled 83% of the eyes treated (p = .006). Mean time to relapse was identical in both groups, that is 24 and 26 months respectively. Most relapses were successfully treated with further local therapy, including laser or cryosurgery, or 60Co plaques. Five eyes required enucleation following initial treatment with the lens-sparing technique, but none thus far with the lateral beam technique. For eyes with Group IV and V disease, no significant differences were found between the two techniques in terms of local control or eventual need for enucleation. With a mean follow-up time of 33 months for the entire group, the 4-year survival is 93%. Two of the 4 deaths are due to second primary tumor, and all 4 have occurred in the lens-sparing group. Because follow-up time is more limited in the lateral beam group, this is not statistically significant and direct survival comparisons are premature

  2. When and how should we teach the basic concepts of radiation beam dosage

    International Nuclear Information System (INIS)

    The difficulty that many trainees, including those medically qualified, have in achieving a sound working grasp of certain basic principles of radiation beam dosage is often underestimated. Since any failure of understanding may seriously impair the efficiency of the team treating the patient, the discussion of these problems (and especially the monitoring of the results of such discussion by means of oral and written tests) deserves a high priority. Contrary to traditional practice, there would seem to be no good reason why teaching of radiation beam dosage, and the effect on dose-rate of changes in the treatment distance or in the amount of scattered radiation, should not begin in the very first week of training and be immediately integrated with discussion of the dose-rate information available at every radiotherapy unit when the patient is treated. A preliminary course of physics lectures does not usually make the understanding of these principles any easier and can be done either concurrently or later. For many radiotherapy trainees and for many doctors in other fields, comparison with drug dosage and with the brightness and scatter of ordinary light beams, avoiding technical terms so far as possible, may achieve a better initial understanding of basic principles than is achieved by mathematical equations and theoretical physics. (author)

  3. Treatment of Head and Neck Paragangliomas With External Beam Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: To retrospectively assess the outcomes of radiation therapy in patients with head and neck paragangliomas. Methods and Materials: From 1990 to 2009, 66 patients with 81 head and neck paragangliomas were treated by conventional external beam radiation therapy in 25 fractions at a median dose of 45 Gy (range, 41.4-68 Gy). One case was malignant. The median gross target volume and planning target volume were 30 cm3 (range, 0.9-243 cm3) and 116 cm3 (range, 24-731 cm3), respectively. Median age was 57.4 years (range, 15-84 years). Eleven patients had multicentric lesions, and 8 had family histories of paraganglioma. Paragangliomas were located in the temporal bone, the carotid body, and the glomus vagal in 51, 18, and 10 patients, respectively. Forty-six patients had exclusive radiation therapy, and 20 had salvage radiation therapy. The median follow-up was 4.1 years (range, 0.1-21.2 years). Results: One patient had a recurrence of temporal bone paraganglioma 8 years after treatment. The actuarial local control rates were 100% at 5 years and 98.7% at 10 years. Patients with multifocal tumors and family histories were significantly younger (42 years vs 58 years [P=.002] and 37 years vs 58 years [P=.0003], respectively). The association between family predisposition and multifocality was significant (P<.001). Two patients had cause-specific death within the 6 months after irradiation. During radiation therapy, 9 patients required hospitalization for weight loss, nausea, mucositis, or ophthalmic zoster. Two late vascular complications occurred (middle cerebral artery and carotid stenosis), and 2 late radiation-related meningiomas appeared 15 and 18 years after treatment. Conclusion: Conventional external beam radiation therapy is an effective and safe treatment option that achieves excellent local control; it should be considered as a first-line treatment of choice for head and neck paragangliomas

  4. Treatment of Head and Neck Paragangliomas With External Beam Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Dupin, Charles, E-mail: c.dupin@bordeaux.unicancer.fr [Department of Radiotherapy, Comprehensive Cancer Center, Institut Bergonié, Bordeaux (France); Lang, Philippe [Department of Radiotherapy, Pitié Salpétrière, Paris (France); Dessard-Diana, Bernadette [Department of Radiotherapy, Hopital Européen Georges Pompidou, Paris (France); Simon, Jean-Marc; Cuenca, Xavier; Mazeron, Jean-Jacques; Feuvret, Loïc [Department of Radiotherapy, Pitié Salpétrière, Paris (France)

    2014-06-01

    Purpose: To retrospectively assess the outcomes of radiation therapy in patients with head and neck paragangliomas. Methods and Materials: From 1990 to 2009, 66 patients with 81 head and neck paragangliomas were treated by conventional external beam radiation therapy in 25 fractions at a median dose of 45 Gy (range, 41.4-68 Gy). One case was malignant. The median gross target volume and planning target volume were 30 cm{sup 3} (range, 0.9-243 cm{sup 3}) and 116 cm{sup 3} (range, 24-731 cm{sup 3}), respectively. Median age was 57.4 years (range, 15-84 years). Eleven patients had multicentric lesions, and 8 had family histories of paraganglioma. Paragangliomas were located in the temporal bone, the carotid body, and the glomus vagal in 51, 18, and 10 patients, respectively. Forty-six patients had exclusive radiation therapy, and 20 had salvage radiation therapy. The median follow-up was 4.1 years (range, 0.1-21.2 years). Results: One patient had a recurrence of temporal bone paraganglioma 8 years after treatment. The actuarial local control rates were 100% at 5 years and 98.7% at 10 years. Patients with multifocal tumors and family histories were significantly younger (42 years vs 58 years [P=.002] and 37 years vs 58 years [P=.0003], respectively). The association between family predisposition and multifocality was significant (P<.001). Two patients had cause-specific death within the 6 months after irradiation. During radiation therapy, 9 patients required hospitalization for weight loss, nausea, mucositis, or ophthalmic zoster. Two late vascular complications occurred (middle cerebral artery and carotid stenosis), and 2 late radiation-related meningiomas appeared 15 and 18 years after treatment. Conclusion: Conventional external beam radiation therapy is an effective and safe treatment option that achieves excellent local control; it should be considered as a first-line treatment of choice for head and neck paragangliomas.

  5. Development and optimization of the LHC and the SPS beam diagnostics based on synchrotron radiation monitoring

    International Nuclear Information System (INIS)

    Measuring the beam transverse emittance is fundamental in every accelerator, in particular for colliders, where its precise determination is essential to maximize the luminosity and thus the performance of the colliding beams. Synchrotron Radiation (SR) is a versatile tool for non-destructive beam diagnostics, since its characteristics are closely related to those of the source beam. At CERN, being the only available diagnostics at high beam intensity and energy, SR monitors are exploited as the proton beam size monitor of the two higher energy machines, the Super Proton Synchrotron (SPS) and the Large Hadron Collider (LHC). The thesis work documented in this report focused on the design, development, characterization and optimization of these beam size monitors. Such studies were based on a comprehensive set of theoretical calculations, numerical simulations and experiments. A powerful simulation tool has been developed combining conventional softwares for SR simulation and optics design, thus allowing the description of an SR monitor from its source up to the detector. The simulations were confirmed by direct observations, and a detailed performance studies of the operational SR imaging monitor in the LHC, where different techniques for experimentally validating the system were applied, such as cross-calibrations with the wire scanners at low intensity (that are considered as a reference) and direct comparison with beam sizes de-convoluted from the LHC luminosity measurements. In 2015, the beam sizes to be measured with the further increase of the LHC beam energy to 7 TeV will decrease down to ∼190 μm. In these conditions, the SR imaging technique was found at its limits of applicability since the error on the beam size determination is proportional to the ratio of the system resolution and the measured beam size. Therefore, various solutions were probed to improve the system's performance such as the choice of one light polarization, the reduction of

  6. High-brightness electron beams for production of high intensity, coherent radiation for scientific and industrial applications

    International Nuclear Information System (INIS)

    Relativistic electron beams with high six-dimensional phase space densities, i.e., high-brightness beams, are the basis for efficient generation of intense and coherent radiation beams for advanced scientific and industrial applications. The remarkable progress in synchrotrons radiation facilities from the first generation to the current, third-generation capability illustrates this point. With the recent development of the high-brightness electron gun based on laser-driven rf photocathodes, linacs have become another important option for high-brightness electron beams. With linacs of about 100 MeV, megawatt-class infrared free-electron lasers can be designed for industrial applications such as power beaming. With linacs of about 10 GeV, 1- angstrom x-ray beams with brightness and time resolution exceeding by several orders of magnitude the current synchrotrons radiation sources can be generated based on self-amplified spontaneous emission. Scattering of a high-brightness electron beam by high power laser beams is emerging as a compact method of generating short-pulse, bright x-rays. In the high-energy frontier, photons of TeV quantum energy could be generated by scattering laser beams with TeV electron beams in future linear colliders

  7. Radiation-induced myocardial perfusion abnormalities in breast cancer patients following external beam radiation therapy

    Directory of Open Access Journals (Sweden)

    Mohammad Eftekhari

    2015-01-01

    Full Text Available Objective(s: Radiation therapy for breast cancer can induce myocardial capillary injury and increase cardiovascular morbidity and mortality. A prospective cohort was conducted to study the prevalence of myocardial perfusion abnormalities following radiation therapy of left-sided breast cancer patients as compared to those with right–sided cancer. Methods: To minimize potential confounding factors, only those patients with low 10-year risk of coronary artery disease (based on Framingham risk scoring were included. All patients were initially treated by modified radical mastectomy and then were managed by postoperative 3D Conformal Radiation Therapy (CRT to the surgical bed with an additional 1-cm margin, delivered by 46-50 Gy (in 2 Gy daily fractions over a 5-week course. The same dose-adjusted chemotherapy regimen (including anthracyclines, cyclophosphamide and taxol was given to all patients. Six months after radiation therapy, all patients underwent cardiac SPECT for the evaluation of myocardial perfusion. Results: A total of 71 patients with a mean age of 45.3±7.2 years [35 patients with leftsided breast cancer (exposed and 36 patients with right-sided cancer (controls] were enrolled. Dose-volume histogram (DVH [showing the percentage of the heart exposed to >50% of radiation] was significantly higher in patients with left-sided breast cancer. Visual interpretation detected perfusion abnormalities in 42.9% of cases and 16.7% of controls (P=0.02, Odds ratio=1.46. In semiquantitative segmental analysis, only apical (28.6% versus 8.3%, P=0.03 and anterolateral (17.1% versus 2.8%, P=0.049 walls showed significantly reduced myocardial perfusion in the exposed group. Summed Stress Score (SSS of>3 was observed in twelve cases (34.3%, while in five of the controls (13.9%,(Odds ratio=1.3. There was no significant difference between the groups regarding left ventricular ejection fraction. Conclusion: The risk of radiation induced myocardial

  8. Effect of incident beam and diffuse radiation on par absorption, photosynthesis and transpiration of sitka spruce - a simulation study

    International Nuclear Information System (INIS)

    A simulation model, Maestro, is used to study the influence of beam fraction in the incident radiation and the radiance distribution of the sky diffuse radiation on PAR absorption, photosynthesis and transpiration of a Sitka spruce (Picea sitchensis (Bong.) Carr) tree crown. It is concluded that inaccurate separation of beam and diffuse radiation leads to significant errors in estimating the amounts of PAR absorbed, photosynthesis and transpiration by a tree in the stand. Much more attention should be paid to adequate descriptions of the radiance distribution of the sky diffuse radiation under different sky conditions. A useful approach is proposed for simulating the incident global radiaiton in a physiological, process-based model

  9. Intense microwave radiation from a repetitive backward-wave oscillator driven by a relativistic electron beam

    International Nuclear Information System (INIS)

    High-power microwaves (20--50 MW, 8.8 GHz) have been produced in repetitive pulses at a rate of 10 Hz in a joint experiment by Harry Diamond Laboratories and Sandia National Laboratories. These microwaves were produced with Harry Diamond Laboratories' backward-wave oscillator (BWO), driven by a 600 to 800-kV, 2-kA electron beam, which was guided by a magnetic field of variable strength from 0.75 to 1.05 T. The beam was produced with Sandia National Laboratories' repetitive high-voltage pulser, RAVEN. Microwave diagnostic instrumentation included a directional coupler, heterodyne receiver, dispersive waveguide delay line, and calorimeter. In a train of 10 pulses, the shape, duration, and amplitude of the injection voltage and beam current remained unchanged for each individual pulse. The intensity of the final microwave pulse was 40% of the first pulse, and the final pulse was 80% as long as the first. The basic pulse shape remained unchanged. More intense microwave radiation should be obtained with a higher magnetic field. Computer simulations using the code magic predicted the characteristic dip in the magnetic field strength versus microwave power output curve. Code predictions of microwave power output with a warm beam agree very well with experimental results. Finally, cyclotron resonance is presented in a descriptive fashion to account for the power output dip. This is the first experiment with a repetitively pulsed high-power BWO driven by a relativistic electron beam performed outside the USSR

  10. Evaluation of parotid function using dynamic parotid scintigraphy in nasopharyngeal carcinoma patients treated with external beam radiation therapy

    International Nuclear Information System (INIS)

    Objective: To evaluation of the parotid function using dynamic parotid scintigraphy in nasopharyngeal carcinoma patients treated with external beam radiation therapy. Methods: Twenty-one nasopharyngeal carcinoma patients were included into this study. Dynamic parotid scintigraphy was performed before and after external beam radiation therapy. Semi-quantitative parameters of parotid (uptake index, excretion rate and excretion index) was used to evaluate the changes of parotid function. Results: UI, ER and EI of parotid were decreased markedly after external beam radiation therapy, t is 56.65, 41.34, 30.69 respectively, P<0.001. The uptake and excretion function of the parotid were all impaired, which correlated with the dray mouth symptom of the patients. Conclusion: Dynamic parotid scintigraphy can play a key role in the evaluation of parotid function in nasopharyngeal carcinoma patients treated with external beam radiation therapy. (authors)

  11. Beam and radiation tests of a fast, warm liquid open-quotes swimming poolclose quotes calorimeter

    International Nuclear Information System (INIS)

    A fast, warm liquid calorimeter module with lead absorber immersed in tetramethyl pentane (TMP) as the liquid medium (i.e. a open-quotes swimming poolclose quotes configuration) has been built and tested in a high energy beam at FNAL, and exposed to intense radiation from a strong Co60 source. A two-tower prototype, incorporating the concept of the electrostatic transformer for fast readout, exhibited very good uniformity and small cross-talk in the beam test. This same calorimeter was exposed to over 10 Mrad of radiation from the Co60 source, and the electron drift lifetime was measured as a function of accumulated dose. The lifetime improved significantly with small doses of radiation, up to a few hundred krad, then decreased gradually at higher doses, and extrapolated to a minimum useful lifetime of 0.1 μs at over 150 Mrad. This result was confirmed by measurements on a small single-electrode test cell which was irradiated to more than 25 Mrad. In this case, the lifetime decreased from 10μs to 0.1 μs when extrapolated to a dose of over 600 Mrad. This cell was also used to measure the effect of positive ion open-quotes space chargeclose quotes buildup under intense radiation. The results suggest that such effects are small even at the highest intensity available, about 1.3 Mrad/day, for applied fields ≥25 kV/cm

  12. A white-beam fast-shutter for microbeam radiation therapy at the ESRF

    CERN Document Server

    Renier, M; Nemoz, C; Thomlinson, W

    2002-01-01

    The ID17 Medical Beamline port at the European Synchrotron Radiation Facility (ESRF) delivers white beam generated by a 1.4 T wiggler. It is devoted to medical applications of synchrotron radiation. One major program of the beamline is called Microbeam Radiation Therapy (MRT). In this radiotherapy technique, still under development, the white beam fan is divided into several microbeams before reaching the target which is a tumoral brain. The maximum skin-entrance absorbed dose can reach extremely high values (over 1000 Gy) before causing tissue necrosis, while causing tumor necrosis. One of the key parameters for the success of the MRT is the accurate control of the radiation dose delivered to the target, as well as its location with respect to the tumor, to prevent unnecessary damage to normal tissues. Therefore, the opening and closing positions of the shutter while the target is moving vertically at a constant speed reaching 150 mm/s must be carefully controlled. Shutter opening times as short as 5+-0.5 ms...

  13. Verification of the alignment of a therapeutic radiation beam relative to its patient positioner.

    Science.gov (United States)

    Barkhof, J; Schut, G; Flanz, J B; Goitein, M; Schippers, J M

    1999-11-01

    An easily-used system has been developed for routine measurements of the alignment of beams used for radiation therapy. The position of a beam of circular cross section is measured with respect to a steel sphere fixed to the patient positioning table and which should coincide with the isocenter. Since measurements can be done at all gantry angles (if one is available) and with all possible orientations of the patient table, the system is particularly suited for rapid and accurate measurements of gantry and/or couch isocentricity. Because it directly measures beam-to-positioner offset, the system provides an inclusive alignment verification of the total treatment system. The system has been developed for use with proton beams, but it could equally be used for alignment checks of an x-ray beam from a linear accelerator or other source. The measuring instrument consists of a scintillation screen viewed by a CCD camera, mounted on the gantry downstream of the sphere. The steel sphere is not large enough to stop protons of all energies of interest; however, it will always modify the energy and direction of protons which intersect it, creating a region of lower intensity (a "shadow") in the light spot created by the proton beam hitting the screen. The position of the shadow with respect to the light spot is a measure of the alignment of the system. An image-analysis algorithm has been developed for an automatic determination of the position of the shadow with respect to the light spot. The specifications and theoretical analysis of the system have been derived from Monte Carlo simulations, which are validated by measurements. We have demonstrated that the device detects beam misalignments with an accuracy (1 s.d.) of 0.05 mm, which is in agreement with the expected performance. This accuracy is more than sufficient to detect the maximum allowed misalignment of +/-0.5 mm. PMID:10587228

  14. Installation And Test Of Electron Beam Generation System To Produce Far-Infrared Radiation And X-Ray Pulses

    International Nuclear Information System (INIS)

    SURIYA project at the Fast Neutron Research Facility, Chiang Mai University, aims to establish a facility to generate femtosecond electron beams. This electron beam can be used to generate high intensity far-infrared radiation and ultra-short X-ray pulses. The main components of the system are a 3 MeV RF electron gun with a thermionic cathode, an a-magnet as a bunch compressor, and post acceleration 15-20 MeV by a linear accelerator (linac). Between the main components, there are focusing quadrupole magnets and steering magnets to maintain the electron beam within a high vacuum tube. At the end of the beam transport line, a dipole magnet has been installed to function as a beam dump and an energy spectrometer. After the installation and testing of individual major components were completed, we have been investigating the generation of the electron beam, intense far- infrared radiation and ultra short X-ray pulses

  15. Radiation grafting of styrene onto polypropylene fibres by a 10 MeV electron beam

    International Nuclear Information System (INIS)

    The radiation-induced graft copolymerization is an effective method for modification of the chemical and physical properties of polypropylene. Graft copolymerization of styrene onto polypropylene fibers has been studied by simultaneous irradiation method, using a 10 MeV electron beam. Samples were irradiated in an environment of nitrogen gas. The effects of radiation dose and styrene concentration in methanol, on the grafting yield were investigated. The effects of polyfunctional monomer, i.e., trimethylopropane trimethacrylate (TMPTMA) and acid (sulfuric acid) on the grafting yield were also examined. The grafted samples were then sulfonated and allowed to react with solution of a basic dye. The samples were characterized by mechanical properties and thermal stability. The mechanical properties of the radiated samples were reduced and the grafted samples had lower mechanical properties

  16. Signatures of quantum radiation reaction in laser-electron-beam collisions

    International Nuclear Information System (INIS)

    Electron dynamics in the collision of an electron beam with a high-intensity focused ultrashort laser pulse are investigated using three-dimensional QED particle-in-cell (PIC) simulations, and the results are compared with those calculated by classical Landau and Lifshitz PIC simulations. Significant differences are observed from the angular dependence of the electron energy distribution patterns for the two different approaches, because photon emission is no longer well approximated by a continuous process in the quantum radiation-dominated regime. The stochastic nature of photon emission results in strong signatures of quantum radiation-reaction effects under certain conditions. We show that the laser spot size and duration greatly influence these signatures due to the competition of QED effects and the ponderomotive force, which is well described in the classical approximation. The clearest signatures of quantum radiation reaction are found in the limit of large laser spots and few cycle pulse durations

  17. Acoustic radiation force on a double-layer microsphere by a Gaussian focused beam

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Rongrong; Cheng, Kaixuan; Liu, Jiehui; Mao, Yiwei; Gong, Xiufen [Key Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing 210093 (China); Liu, Xiaozhou, E-mail: xzliu@nju.edu.cn [Key Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing 210093 (China); State Key Laboratory of Acoustics, Institute of Acoustics, Chinese Academy of Sciences, Beijing 100190 (China)

    2014-10-14

    A new model for calculating the radiation force on double-layer microsphere is proposed based on the ray acoustics approach. The axial acoustic radiation force resulting from a focused Gaussian beam incident on spherical shells immersed in water is examined theoretically in relation to its thickness and the contents of its double-layer. The attenuation both in the water and inside the sphere is considered in this method, which cannot be ignored while the high frequency ultrasonic is used. Results of numerical calculations are presented for fat and low density polyethylene materials, with the hollow region filled with animal oil, water, or air. These results show how the acoustic impedance and the sound velocity of both layers, together with the thickness of the shell, affect the acoustic radiation force.

  18. The use of different type of electron beam radiation equipment for biotechnological materials

    International Nuclear Information System (INIS)

    The potential of using electron beam radiation and bremsstrahlung for some biotechnological materials treatment is presented based on the results of the R and D programme established in 1993 at the Institute of Lasers, Plasma and Radiation Physics Bucharest, Electron Accelerator Laboratory. The main parameters of different electron accelerator types used to process biotechnological materials are presented as these machines were designed, developed and improved. In order to fulfil the radiation processing requirements for biotechnology and environmental protection, betatron, linear and microtron-type electron accelerators are considered and there is an interest to develop a dedicated one as well. The results of irradiation of different biotechnological items as cell cultures, microbial strains, enzymes and biopreparates and cellulose-based wastes are presented

  19. Belle-II VXD radiation monitoring and beam abort with sCVD diamond sensors

    Science.gov (United States)

    Adamczyk, K.; Aihara, H.; Angelini, C.; Aziz, T.; Babu, V.; Bacher, S.; Bahinipati, S.; Barberio, E.; Baroncelli, T.; Basith, A. K.; Batignani, G.; Bauer, A.; Behera, P. K.; Bergauer, T.; Bettarini, S.; Bhuyan, B.; Bilka, T.; Bosi, F.; Bosisio, L.; Bozek, A.; Buchsteiner, F.; Casarosa, G.; Ceccanti, M.; Červenkov, D.; Chendvankar, S. R.; Dash, N.; Divekar, S. T.; Doležal, Z.; Dutta, D.; Forti, F.; Friedl, M.; Hara, K.; Higuchi, T.; Horiguchi, T.; Irmler, C.; Ishikawa, A.; Jeon, H. B.; Joo, C.; Kandra, J.; Kang, K. H.; Kato, E.; Kawasaki, T.; Kodyš, P.; Kohriki, T.; Koike, S.; Kolwalkar, M. M.; Kvasnička, P.; Lanceri, L.; Lettenbicher, J.; Mammini, P.; Mayekar, S. N.; Mohanty, G. B.; Mohanty, S.; Morii, T.; Nakamura, K. R.; Natkaniec, Z.; Negishi, K.; Nisar, N. K.; Onuki, Y.; Ostrowicz, W.; Paladino, A.; Paoloni, E.; Park, H.; Pilo, F.; Profeti, A.; Rashevskaya, I.; Rao, K. K.; Rizzo, G.; Rozanska, M.; Sandilya, S.; Sasaki, J.; Sato, N.; Schultschik, S.; Schwanda, C.; Seino, Y.; Shimizu, N.; Stypula, J.; Tanaka, S.; Tanida, K.; Taylor, G. N.; Thalmeier, R.; Thomas, R.; Tsuboyama, T.; Uozumi, S.; Urquijo, P.; Vitale, Lorenzo; Volpi, M.; Watanuki, S.; Watson, I. J.; Webb, J.; Wiechczynski, J.; Williams, S.; Würkner, B.; Yamamoto, H.; Yin, H.; Yoshinobu, T.

    2016-07-01

    The Belle-II VerteX Detector (VXD) has been designed to improve the performances with respect to Belle and to cope with an unprecedented luminosity of 8 ×1035cm-2s-1 achievable by the SuperKEKB. Special care is needed to monitor both the radiation dose accumulated throughout the life of the experiment and the instantaneous radiation rate, in order to be able to promptly react to sudden spikes for the purpose of protecting the detectors. A radiation monitoring and beam abort system based on single-crystal diamond sensors is now under an active development for the VXD. The sensors will be placed in several key positions in the vicinity of the interaction region. The severe space limitations require a challenging remote readout of the sensors.

  20. Signatures of quantum radiation reaction in laser-electron-beam collisions

    Energy Technology Data Exchange (ETDEWEB)

    Wang, H. Y. [Helmholtz Institute Jena, Fröbelstieg 3, 07743 Jena (Germany); Yan, X. Q. [State Key Laboratory of Nuclear Physics and Technology, and Key Lab of High Energy Density Physics Simulation, CAPT, Peking University, Beijing 100871 (China); Zepf, M., E-mail: m.zepf@uni-jena.de [Helmholtz Institute Jena, Fröbelstieg 3, 07743 Jena (Germany); School of Mathematics and Physics, Queen' s University Belfast, Belfast BT7 1NN (United Kingdom)

    2015-09-15

    Electron dynamics in the collision of an electron beam with a high-intensity focused ultrashort laser pulse are investigated using three-dimensional QED particle-in-cell (PIC) simulations, and the results are compared with those calculated by classical Landau and Lifshitz PIC simulations. Significant differences are observed from the angular dependence of the electron energy distribution patterns for the two different approaches, because photon emission is no longer well approximated by a continuous process in the quantum radiation-dominated regime. The stochastic nature of photon emission results in strong signatures of quantum radiation-reaction effects under certain conditions. We show that the laser spot size and duration greatly influence these signatures due to the competition of QED effects and the ponderomotive force, which is well described in the classical approximation. The clearest signatures of quantum radiation reaction are found in the limit of large laser spots and few cycle pulse durations.

  1. Disinfestation of agricultural products with electron beams and their radiation tolerance

    International Nuclear Information System (INIS)

    Some agricultural products contaminated with insect pests are fumigated with methyl bromide for quarantine purposes. However, the use of methyl bromide is preferably restricted because of its ozone depleting effect. Therefore, establishing alternative quarantine techniques is highly desirable; one such technique is exposure to ionizing radiation. Few data are available on the effects of radiation on insect pests other than fruit flies and stored-product insects and on the radiation tolerance of host commodities. Radiation technology as an alternative to methyl bromide fumigation will be used to inactivate not only insects but also mites, spider mites, thrips, nematodes, scales, mealybugs and thrips contaminating fruits, grains, cut flowers, vegetables, timbers, seedlings and seeds. In order to collect data on the effects of irradiation on pests and host commodities, IAEA and FAO have conducted an international project, 'FAO/IAEA Coordinated Research Programme on Irradiation as a Quarantine Treatment of Mites, Nematodes and Insects other than Fruit Fly' since 1992. The project determines the minimum doses necessary to inactivate pests and the maximum doses host commodities tolerate. All pests except nematodes can be inactivated at doses 400Gy or lower. Various varieties of cut flowers and herbs are tolerant to 400Gy of radiation, although some flowers and herbs such as chrysanthemum, rose, lily, calla, anthurium, sweet pea, iris, dill, basil and arugula are intolerant to 200Gy of radiation. Japanese research project on treatment of cut flowers with electron beams carried out mainly by Yokohama Plant Protection Station greatly contributes to these conclusions. Aqueous solution (2%) of sucrose, glucose, fructose or maltose prevents radiation-induced detrimental effects of radiation on chrysanthemums. Sugars reduce radiation-induced physiological deterioration of chrysanthemums. (author)

  2. Effect on the insulation material of a MOSFET device submitted to a standard diagnostic radiation beam

    International Nuclear Information System (INIS)

    MOSFET electronic devices have been used for dosimetry in radiology and radiotherapy. Several communications show that due to the radiation exposure defects appear on the semiconductor crystal lattice. Actually, the structure of a MOSFET consists of three materials: a semiconductor, a metal and an insulator between them. The MOSFET is a quadripolar device with a common terminal: gate-source is the input; drain-source is the output. The gate controls the electrical current passing through semiconductor medium by the field effect because the silicon oxide acts as insulating material. The proposal of this work is to show some radiation effects on the insulator of a MOSFET device. A 6430 Keithley sub-femtoamp SourceMeter was used to verify how the insulating material layer in the structure of the device varies with the radiation exposure. We have used the IEC 61267 standard radiation X-ray beams generated from a Pantak industrial unit in the radiation energy range of computed tomography. This range was chosen because we are using the MOSFET device as radiation detector for dosimetry in computed tomography. The results showed that the behaviour of the electrical current of the device is different in the insulator and semiconductor structures.

  3. Dynamic mechanical studies on epoxy resins cured by electron beam radiation

    International Nuclear Information System (INIS)

    Dynamic mechanical analyses on electron beam (EB)-cured epoxy resins were made in the paper. Through the studies on variation rules of gel fraction, tan δ and storage modulus for varied samples, the important effects of EB radiation dosage, initiator dosage, chemical structure, molecular weight and distribution, and heat treatment on curing reaction and properties of epoxy resin systems have been obtained. Under low radiation doses, the gel fraction, glass transition temperature (Tg) and high temperature modulus of cured epoxy resin increase with increasing radiation dose and initiator dosage. The crosslinking density of epoxy resin decreases slightly with increasing molecular weight. When radiation doses increase, the molecular weight has a little influence on the increasing of curing level and an optimal dosage of initiator appears. The experimental results indicate that the radiation reactivity of epoxy resins is directly associated with their chemical structures. Under the same radiation dose, the reaction extent in sample with high polydispersity is higher than that in low polydispersity sample, but the degree of homogeneity in crosslinking structure is lower. When the EB-cured epoxy resin is heated, the crosslinking density is enhanced. If the temperature of heating treatment exceeds the thermal-initiating temperature of initiator, the local thermal-crosslinking network can be formed in resin system

  4. Effect on the insulation material of a MOSFET device submitted to a standard diagnostic radiation beam

    Energy Technology Data Exchange (ETDEWEB)

    De Magalhaes, C M S; Dos Santos, L A P; Souza, D do N; Maia, A F, E-mail: cinthiamsm@yahoo.com.b

    2010-11-01

    MOSFET electronic devices have been used for dosimetry in radiology and radiotherapy. Several communications show that due to the radiation exposure defects appear on the semiconductor crystal lattice. Actually, the structure of a MOSFET consists of three materials: a semiconductor, a metal and an insulator between them. The MOSFET is a quadripolar device with a common terminal: gate-source is the input; drain-source is the output. The gate controls the electrical current passing through semiconductor medium by the field effect because the silicon oxide acts as insulating material. The proposal of this work is to show some radiation effects on the insulator of a MOSFET device. A 6430 Keithley sub-femtoamp SourceMeter was used to verify how the insulating material layer in the structure of the device varies with the radiation exposure. We have used the IEC 61267 standard radiation X-ray beams generated from a Pantak industrial unit in the radiation energy range of computed tomography. This range was chosen because we are using the MOSFET device as radiation detector for dosimetry in computed tomography. The results showed that the behaviour of the electrical current of the device is different in the insulator and semiconductor structures.

  5. Enacting laws concerning radiation safety management for students using X-rays and electron beams under 1 MeV

    International Nuclear Information System (INIS)

    Laws concerning radiation safety management were analyzed from the point of view of defining precisely what is meant by radiation and what is meant by the subject. There are no laws to protect students from radiation hazards when using X-rays and electron beams under 1 MeV for research and/or education. The Law concerning Technical Standards for Preventing Radiation Hazards gives the authorities the power to enact new rules and regulations that will protect the students. The Radiation Council must take charge for enactment of all laws regarding radiation safety management. (author)

  6. eBooking of beam-time over internet for beamlines of Indus synchrotron radiation sources

    International Nuclear Information System (INIS)

    Users from various research labs and academic institutes carry out experiments on beamlines of two Synchrotron Radiation Sources Indus-1 and Indus-2 available at RRCAT, Indore. To carry out experimental work on beamlines of both synchrotron radiation sources, beam-time is booked over Internet by the users of beamlines using user portal designed, developed and deployed over Internet. This portal has made the process of beamtime booking fast, hassle free and paperless as manual booking of beam-time for carrying out experiment on a particular beamline is cumbersome. The portal facilitates in-charge of Indus-1 and Indus-2 beamlines to keep track of users' records, work progress and other activities linked to experiments carried on beamlines. It is important to keep record and provide statistics about the usage of the beam lines from time-to-time. The user portal for e-booking of beam-time has been developed in-house using open source software development tools. Multi-step activities of users and beamline administrators are workflow based with seamless flow of information across various modules and fully authenticated using role based mechanism for different roles of software usage. The software is in regular use since November 2013 and has helped beamline in- charges in efficiently managing various activities related to user registration, booking of beam-time, booking of Guest House, Generation of Security permits, User feedback etc. Design concept, role based authentication mechanism and features provided by the web portal are discussed in detail in this paper. (author)

  7. Beam transport radiation shielding for branch lines 2-ID-B and 2-ID-C

    International Nuclear Information System (INIS)

    The x-ray radiation shielding requirements beyond the first optics enclosure have been considered for the beam transport of the 2-ID-B and 2-ID-C branch lines of Sector 2 (SRI-CAT) of the APS. The first three optical components (mirrors) of the 2-ID-B branch are contained within the shielded first optics enclosure. Calculations indicate that scattering of the primary synchrotron beam by beamline components outside the enclosure, such as apertures and monochromators, or by gas particles in case of vacuum failure is within safe limits for this branch. A standard 2.5-inch-diameter stainless steel pipe with 1/16-inch-thick walls provides adequate shielding to reduce the radiation dose equivalent rate to human tissue to below the maximum permissible limit of 0.25 mrem/hr. The 2-ID-C branch requires, between the first optics enclosure where only two mirrors are used and the housing for the third mirror, additional lead shielding (0.75 mm) and a minimum approach distance of 2.6 cm. A direct beam stop consisting of at least 4.5 mm of lead is also required immediately downstream of the third mirror for 2-ID-C. Finally, to stop the direct beam from escaping the experimental station, a beam stop consisting of at least 4-mm or 2.5-mm steel is required for the 2-ID-B or 2-ID-C branches, respectively. This final requirement can be met by the vacuum chambers used to house the experiments for both branch lines

  8. Beam angle optimization for intensity-modulated radiation therapy using a guided pattern search method

    Science.gov (United States)

    Rocha, Humberto; Dias, Joana M.; Ferreira, Brígida C.; Lopes, Maria C.

    2013-05-01

    Generally, the inverse planning of radiation therapy consists mainly of the fluence optimization. The beam angle optimization (BAO) in intensity-modulated radiation therapy (IMRT) consists of selecting appropriate radiation incidence directions and may influence the quality of the IMRT plans, both to enhance better organ sparing and to improve tumor coverage. However, in clinical practice, most of the time, beam directions continue to be manually selected by the treatment planner without objective and rigorous criteria. The goal of this paper is to introduce a novel approach that uses beam’s-eye-view dose ray tracing metrics within a pattern search method framework in the optimization of the highly non-convex BAO problem. Pattern search methods are derivative-free optimization methods that require a few function evaluations to progress and converge and have the ability to better avoid local entrapment. The pattern search method framework is composed of a search step and a poll step at each iteration. The poll step performs a local search in a mesh neighborhood and ensures the convergence to a local minimizer or stationary point. The search step provides the flexibility for a global search since it allows searches away from the neighborhood of the current iterate. Beam’s-eye-view dose metrics assign a score to each radiation beam direction and can be used within the pattern search framework furnishing a priori knowledge of the problem so that directions with larger dosimetric scores are tested first. A set of clinical cases of head-and-neck tumors treated at the Portuguese Institute of Oncology of Coimbra is used to discuss the potential of this approach in the optimization of the BAO problem.

  9. Beam angle optimization for intensity-modulated radiation therapy using a guided pattern search method

    International Nuclear Information System (INIS)

    Generally, the inverse planning of radiation therapy consists mainly of the fluence optimization. The beam angle optimization (BAO) in intensity-modulated radiation therapy (IMRT) consists of selecting appropriate radiation incidence directions and may influence the quality of the IMRT plans, both to enhance better organ sparing and to improve tumor coverage. However, in clinical practice, most of the time, beam directions continue to be manually selected by the treatment planner without objective and rigorous criteria. The goal of this paper is to introduce a novel approach that uses beam’s-eye-view dose ray tracing metrics within a pattern search method framework in the optimization of the highly non-convex BAO problem. Pattern search methods are derivative-free optimization methods that require a few function evaluations to progress and converge and have the ability to better avoid local entrapment. The pattern search method framework is composed of a search step and a poll step at each iteration. The poll step performs a local search in a mesh neighborhood and ensures the convergence to a local minimizer or stationary point. The search step provides the flexibility for a global search since it allows searches away from the neighborhood of the current iterate. Beam’s-eye-view dose metrics assign a score to each radiation beam direction and can be used within the pattern search framework furnishing a priori knowledge of the problem so that directions with larger dosimetric scores are tested first. A set of clinical cases of head-and-neck tumors treated at the Portuguese Institute of Oncology of Coimbra is used to discuss the potential of this approach in the optimization of the BAO problem. (paper)

  10. Imaging Changes in Pediatric Intracranial Ependymoma Patients Treated With Proton Beam Radiation Therapy Compared to Intensity Modulated Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Gunther, Jillian R. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Sato, Mariko; Chintagumpala, Murali [Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Texas Children' s Cancer Center, Houston, Texas (United States); Ketonen, Leena [Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Jones, Jeremy Y. [Department of Pediatric Radiology, Texas Children' s Hospital, Houston, Texas (United States); Allen, Pamela K. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Paulino, Arnold C. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Texas Children' s Cancer Center, Houston, Texas (United States); Okcu, M. Fatih; Su, Jack M. [Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Texas Children' s Cancer Center, Houston, Texas (United States); Weinberg, Jeffrey [Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Boehling, Nicholas S. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Khatua, Soumen [Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Adesina, Adekunle [Department of Pathology, Baylor College of Medicine, Texas Children' s Hospital, Houston, Texas (United States); Dauser, Robert; Whitehead, William E. [Department of Neurosurgery, Texas Children' s Hospital, Houston, Texas (United States); Mahajan, Anita, E-mail: amahajan@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2015-09-01

    Purpose: The clinical significance of magnetic resonance imaging (MRI) changes after radiation therapy (RT) in children with ependymoma is not well defined. We compared imaging changes following proton beam radiation therapy (PBRT) to those after photon-based intensity modulated RT (IMRT). Methods and Materials: Seventy-two patients with nonmetastatic intracranial ependymoma who received postoperative RT (37 PBRT, 35 IMRT) were analyzed retrospectively. MRI images were reviewed by 2 neuroradiologists. Results: Sixteen PBRT patients (43%) developed postradiation MRI changes at 3.8 months (median) with resolution by 6.1 months. Six IMRT patients (17%) developed changes at 5.3 months (median) with 8.3 months to resolution. Mean age at radiation was 4.4 and 6.9 years for PBRT and IMRT, respectively (P=.06). Age at diagnosis (>3 years) and time of radiation (≥3 years) was associated with fewer imaging changes on univariate analysis (odds ratio [OR]: 0.35, P=.048; OR: 0.36, P=.05). PBRT (compared to IMRT) was associated with more frequent imaging changes, both on univariate (OR: 3.68, P=.019) and multivariate (OR: 3.89, P=.024) analyses. Seven (3 IMRT, 4 PBRT) of 22 patients with changes had symptoms requiring intervention. Most patients were treated with steroids; some PBRT patients also received bevacizumab and hyperbaric oxygen therapy. None of the IMRT patients had lasting deficits, but 2 patients died from recurrent disease. Three PBRT patients had persistent neurological deficits, and 1 child died secondarily to complications from radiation necrosis. Conclusions: Postradiation MRI changes are more common with PBRT and in patients less than 3 years of age at diagnosis and treatment. It is difficult to predict causes for development of imaging changes that progress to clinical significance. These changes are usually self-limiting, but some require medical intervention, especially those involving the brainstem.

  11. Imaging Changes in Pediatric Intracranial Ependymoma Patients Treated With Proton Beam Radiation Therapy Compared to Intensity Modulated Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: The clinical significance of magnetic resonance imaging (MRI) changes after radiation therapy (RT) in children with ependymoma is not well defined. We compared imaging changes following proton beam radiation therapy (PBRT) to those after photon-based intensity modulated RT (IMRT). Methods and Materials: Seventy-two patients with nonmetastatic intracranial ependymoma who received postoperative RT (37 PBRT, 35 IMRT) were analyzed retrospectively. MRI images were reviewed by 2 neuroradiologists. Results: Sixteen PBRT patients (43%) developed postradiation MRI changes at 3.8 months (median) with resolution by 6.1 months. Six IMRT patients (17%) developed changes at 5.3 months (median) with 8.3 months to resolution. Mean age at radiation was 4.4 and 6.9 years for PBRT and IMRT, respectively (P=.06). Age at diagnosis (>3 years) and time of radiation (≥3 years) was associated with fewer imaging changes on univariate analysis (odds ratio [OR]: 0.35, P=.048; OR: 0.36, P=.05). PBRT (compared to IMRT) was associated with more frequent imaging changes, both on univariate (OR: 3.68, P=.019) and multivariate (OR: 3.89, P=.024) analyses. Seven (3 IMRT, 4 PBRT) of 22 patients with changes had symptoms requiring intervention. Most patients were treated with steroids; some PBRT patients also received bevacizumab and hyperbaric oxygen therapy. None of the IMRT patients had lasting deficits, but 2 patients died from recurrent disease. Three PBRT patients had persistent neurological deficits, and 1 child died secondarily to complications from radiation necrosis. Conclusions: Postradiation MRI changes are more common with PBRT and in patients less than 3 years of age at diagnosis and treatment. It is difficult to predict causes for development of imaging changes that progress to clinical significance. These changes are usually self-limiting, but some require medical intervention, especially those involving the brainstem

  12. Radiative lifetimes in MoI using a novel atomic beam source

    International Nuclear Information System (INIS)

    Radiative lifetimes of the 4d5(a6S)5pz7P0 levels and the 4d5(a6S)5pz5P0 levels in MoI are reported as follows: tau(z7P04) = 15.9 ns, tau(z7P03) = 17.0 ns, tau(z7P02) = 17.1 ns, tau(z5P03) = 22.3 ns, tau(z5P02) = 22.1 ns, and tau(z5P01) = 21.7 ns (+-5%). The lifetimes are measured using time resolved laser induced fluorescence and a novel atomic beam source. This novel hollow cathode effusive beam source produces an intense beam of ground state Mo atoms and metastable Mo atoms. Our measurements on the z7P0 levels are in agreement with earlier lifetime measurements. Our measurements on the z5P0 levels are the first direct radiative lifetime measurements of these levels; the z5P0 measurements are of particular interest because the a5S → z5P0 multiplet is used to determine the solar abundance of Mo. (orig.)

  13. Improving the Fermilab Booster Notching Efficiency, Beam Losses and Radiation Levels

    Energy Technology Data Exchange (ETDEWEB)

    Rakhno, I.L.; Drozhdin, A.I.; Mokhov, N.V.; Sidorov, V.I.; Tropin, I.S.; /Fermilab

    2012-05-14

    A fast vertical 1.08-m long kicker (notcher) located in the Fermilab Booster Long-05 straight section is currently used to remove 3 out of 84 circulating bunches after injection to generate an abort gap. With the maximum magnetic field of 72.5 Gauss, it removes only 87% of the 3-bunch intensity at 400 MeV, with 75% loss on pole tips of the focusing Booster magnets, 11% on the Long-06 collimators, and 1% in the rest of the ring. We propose to improve the notching efficiency and reduce beam loss in the Booster by using three horizontal kickers in the Long-12 section. STRUCT calculations show that using horizontal notchers, one can remove up to 96% of the 3-bunch intensity at 400-700 MeV, directing 95% of it to a new beam dump at the Long-13 section. This fully decouples notching and collimation. The beam dump absorbs most of the impinging proton energy in its jaws. The latter are encapsulated into an appropriate radiation shielding that reduces impact on the machine components, personnel and environment to the tolerable levels. MARS simulations show that corresponding prompt and residual radiation levels can be reduced ten times compared to the current ones.

  14. Experimental Investigation on a Radiation Beam Steering Function of a Plate Waveguide Sensor

    International Nuclear Information System (INIS)

    Liquid sodium is used as the coolant in a Sodium Fast Reactor (SFR). As the liquid sodium is opaque to light, a conventional visual inspection can not be used for performing an inservice inspection of the internal structures under a sodium level. An ultrasonic wave should be applied for an under-sodium visual inspection of the reactor internals. Under-sodium ultrasonic sensors have been widely developed for a visual inspection of the reactor core and the internal components of SFR. Immersion sensors and waveguide sensors have been applied to the under-sodium visualization. The immersion sensor has a precise imaging capability, but may have high temperature restrictions and an uncertain life. The waveguide sensor has the advantages of a long lifetime and stable application. Recently a new plate-type waveguide sensor has been developed for an under-sodium visual inspection. And a new technique is presented which is capable of steering an ultrasonic beam of a waveguide sensor without a mechanical movement of the sensor assembly. The steering function of the ultrasonic radiation beam can be achieved by a frequency tuning method of the excitation pulse in the dispersive low frequency range of the A0 plate wave. In this study, experimental verifications of an ultrasonic radiation beam propagation of a plate waveguide sensor are performed

  15. Generation and modelling of megavoltage photon beams for contrast-enhanced radiation therapy

    Science.gov (United States)

    Robar, J. L.

    2006-11-01

    Contrast-enhanced radiation therapy (CERT) is a treatment approach involving the irradiation of tumours containing high atomic number (Z) contrast media, using low-quality x-ray beams. This work describes the experimental generation of x-ray beams using a linear accelerator with low-Z target materials (beryllium and aluminium), in order to produce photon energy spectra appropriate for CERT. Measurements were made to compare the experimental beams to conventional linear accelerator photon beams in terms of per cent depth dose. Monte Carlo simulation was used to model the generation of each beam, and models were validated against experimental measurement. Validated models were used to demonstrate changes in photon spectra as well as to quantify the variation of tumour dose enhancement with iodinated contrast medium concentration in a simulated tumour volume. Finally, the ratio of the linear attenuation coefficient for iodinated contrast medium relative to water was determined experimentally as a function of iodine concentration. Beams created with low-Z targets show significant changes in energy spectra compared to conventional beams. For the 4 MeV/Be beam, for example, 33% of photons have energies below 60 keV. Measurements and calculation show that both the linear attenuation coefficient ratio and dose enhancement factor (DEF) increase most rapidly at concentrations below 46 mg I ml-1. There is a significant dependence of DEF on electron energy and a lesser dependence on target material. The 4 MeV/Be beam is the most promising in terms of magnitude of DEF—for example, DEF values of 1.16 and 1.29 are obtained for concentrations of 20 mg I ml-1 and 50 mg I ml-1, respectively. DEF will increase or decrease, respectively, for shallower or deeper tumours at a rate of approximately 1.1% cm-1. In summary, we show that significant dose enhancement is possible by altering the linear accelerator target and filtration, but the magnitude is highly dependent on contrast

  16. Two-parametric model of electron beam in computational dosimetry for radiation processing

    Science.gov (United States)

    Lazurik, V. M.; Lazurik, V. T.; Popov, G.; Zimek, Z.

    2016-07-01

    Computer simulation of irradiation process of various materials with electron beam (EB) can be applied to correct and control the performances of radiation processing installations. Electron beam energy measurements methods are described in the international standards. The obtained results of measurements can be extended by implementation computational dosimetry. Authors have developed the computational method for determination of EB energy on the base of two-parametric fitting of semi-empirical model for the depth dose distribution initiated by mono-energetic electron beam. The analysis of number experiments show that described method can effectively consider random displacements arising from the use of aluminum wedge with a continuous strip of dosimetric film and minimize the magnitude uncertainty value of the electron energy evaluation, calculated from the experimental data. Two-parametric fitting method is proposed for determination of the electron beam model parameters. These model parameters are as follow: E0 - energy mono-energetic and mono-directional electron source, X0 - the thickness of the aluminum layer, located in front of irradiated object. That allows obtain baseline data related to the characteristic of the electron beam, which can be later on applied for computer modeling of the irradiation process. Model parameters which are defined in the international standards (like Ep- the most probably energy and Rp - practical range) can be linked with characteristics of two-parametric model (E0, X0), which allows to simulate the electron irradiation process. The obtained data from semi-empirical model were checked together with the set of experimental results. The proposed two-parametric model for electron beam energy evaluation and estimation of accuracy for computational dosimetry methods on the base of developed model are discussed.

  17. A nested partitions framework for beam angle optimization in intensity-modulated radiation therapy

    International Nuclear Information System (INIS)

    Coupling beam angle optimization with dose optimization in intensity-modulated radiation therapy (IMRT) increases the size and complexity of an already large-scale combinatorial optimization problem. We have developed a novel algorithm, nested partitions (NP), that is capable of finding suitable beam angle sets by guiding the dose optimization process. NP is a metaheuristic that is flexible enough to guide the search of a heuristic or deterministic dose optimization algorithm. The NP method adaptively samples from the entire feasible region, or search space, and coordinates the sampling effort with a systematic partitioning of the feasible region at successive iterations, concentrating the search in promising subsets. We used a 'warm-start' approach by initiating NP with beam angle samples derived from an integer programming (IP) model. In this study, we describe our implementation of the NP framework with a commercial optimization algorithm. We compared the NP framework with equi-spaced beam angle selection, the IP method, greedy heuristic and random sampling heuristic methods. The results of the NP approach were evaluated using two clinical cases (head and neck and whole pelvis) involving the primary tumor and nodal volumes. Our results show that NP produces better quality solutions than the alternative considered methods

  18. Chromium Waste Treatment from Leather Manufacture Using Electron Beam Radiation Technic

    International Nuclear Information System (INIS)

    Leather manufacture chromium waste treatment using chemical methods have an essential disadvantage, because of the production of the secondary contamination of wastes and separated sediments used by reagents. Therefore, a new technique is needed to solve this problem. The aim of the research to learn the advantages of electron beam radiation for chromium waste treatment. Water radiolysis can be produced by the interaction between electron beam and water or liquid substances. This phenomenon produces many reducing agents and ions that could reduce chromium concentrations in the liquid waste. Ethyl alcohol as a scavenger was added in the waste samples, then the pH of varied from 1, 4, 8 to 12, then were irradiated. Irradiation were done by Electron Beam Machine with dose 15, 25, and 35 kGy. After irradiation, chromium concentration in the samples were analyzed by AAS and UV-vis spectrophotometer. The results had shown that chromium could be reduced by high dose electron beam. The optimum reduction of chromium was achieved at liquid waste pH 8 and irradiation dose 35 kGy. (author)

  19. Implementation of a system for external audits beam radiation therapy in terms of reference no

    International Nuclear Information System (INIS)

    This paper presents our experience in implementing a external audit system for radiotherapy beam in no reference conditions with the use of CIRS and a summary of the measurements with him made.This paper presents our experience in implementing a external audit system for radiotherapy beam in no reference conditions with the use of CIRS and a summary of the measurements with him made. Centers were audited with external beam high-energy Co-60, 6 MV and 15 MV and were considered 4 treatment planning systems (TPS): AMEPLAN, Theraplan Plus, Precise Plan and MIRS to calculate doses prescribed in each test case. All measurements were acquired by the audit team using the anthropomorphic phantom CIRS, Semiflex chamber PTW 31010 and PTW electrometer STATES. The implementation and development of the external audits of beams radiotherapy in terms of 'no reference' has brought an improvement in both clinical aspects of treatment and the radiation safety and the quality control, has given us greater confidence and for this reason we believe has become essential. (Author)

  20. Direct-aperture optimization applied to selection of beam orientations in intensity-modulated radiation therapy

    International Nuclear Information System (INIS)

    Direct-aperture optimization (DAO) was applied to iterative beam-orientation selection in intensity-modulated radiation therapy (IMRT), so as to ensure a realistic segmental treatment plan at each iteration. Nested optimization engines dealt separately with gantry angles, couch angles, collimator angles, segment shapes, segment weights and wedge angles. Each optimization engine performed a random search with successively narrowing step sizes. For optimization of segment shapes, the filtered backprojection (FBP) method was first used to determine desired fluence, the fluence map was segmented, and then constrained direct-aperture optimization was used thereafter. Segment shapes were fully optimized when a beam angle was perturbed, and minimally re-optimized otherwise. The algorithm was compared with a previously reported method using FBP alone at each orientation iteration. An example case consisting of a cylindrical phantom with a hemi-annular planning target volume (PTV) showed that for three-field plans, the method performed better than when using FBP alone, but for five or more fields, neither method provided much benefit over equally spaced beams. For a prostate case, improved bladder sparing was achieved through the use of the new algorithm. A plan for partial scalp treatment showed slightly improved PTV coverage and lower irradiated volume of brain with the new method compared to FBP alone. It is concluded that, although the method is computationally intensive and not suitable for searching large unconstrained regions of beam space, it can be used effectively in conjunction with prior class solutions to provide individually optimized IMRT treatment plans

  1. A nested partitions framework for beam angle optimization in intensity-modulated radiation therapy

    Science.gov (United States)

    D'Souza, Warren D.; Zhang, Hao H.; Nazareth, Daryl P.; Shi, Leyuan; Meyer, Robert R.

    2008-06-01

    Coupling beam angle optimization with dose optimization in intensity-modulated radiation therapy (IMRT) increases the size and complexity of an already large-scale combinatorial optimization problem. We have developed a novel algorithm, nested partitions (NP), that is capable of finding suitable beam angle sets by guiding the dose optimization process. NP is a metaheuristic that is flexible enough to guide the search of a heuristic or deterministic dose optimization algorithm. The NP method adaptively samples from the entire feasible region, or search space, and coordinates the sampling effort with a systematic partitioning of the feasible region at successive iterations, concentrating the search in promising subsets. We used a 'warm-start' approach by initiating NP with beam angle samples derived from an integer programming (IP) model. In this study, we describe our implementation of the NP framework with a commercial optimization algorithm. We compared the NP framework with equi-spaced beam angle selection, the IP method, greedy heuristic and random sampling heuristic methods. The results of the NP approach were evaluated using two clinical cases (head and neck and whole pelvis) involving the primary tumor and nodal volumes. Our results show that NP produces better quality solutions than the alternative considered methods.

  2. Improving precision and safety in the use of beam modifying devices in radiation therapy

    International Nuclear Information System (INIS)

    Reliable and safe implementation of beam modifying devices such as wedges and block trays requires careful design and construction. Inappropriate design may pose problems ranging from user-hostile operation to hard-to-track, but significant variations in actual position in a beam. This may cause variation in actual wedge output factors, or variation in the position of a block tray. In case of simple mechanical failure or personnel mistake, design related mechanical conditions may result in injury to either a patient or a staff member. This paper is based on experience with linear accelerators from one manufacturer, but similar conditions are likely to exist with other radiation machines. A simple technical modification is offered which improves both accuracy and reproducibility in the placement of wedge-type filters. For our machines the solution also provides improved safety in the use of both wedge trays and block trays

  3. Inclined-incidence quasi-Fresnel lens for prefocusing of synchrotron radiation x-ray beams

    International Nuclear Information System (INIS)

    An inclined-incidence quasi-Fresnel lens made of acrylic resin has been developed for prefocusing in synchrotron radiation x-ray beamlines. By inclining the lens, the grating aspect ratio is large enough for x-ray use. As it operates in transmission mode with negligible beam deflection and offset, little additional equipment is needed to introduce it into existing beamlines. It is fabricated by sheet-press forming, enabling inexpensive mass production. The prototype was able to focus a 730-μm-wide beam to a width of 80 μm with a photon flux density gain of 5.6 at an x-ray energy of 10 keV.

  4. Calculation and measurement of build-up factors in divergent gamma radiation beams

    International Nuclear Information System (INIS)

    The methods and the results are presented of the calculation and experimental determination of build-up factors in a broad divergent gamma radiation beam passing through a planar layer of material. A computer program based on the Monte Carlo method is described as is the experimental configuration used. The dependence was determined of the build-up factor on the beam collimation angle, the distance of the source and the distance of the detector from the layer to be radiographed. No dependence was confirmed on the detector diameter. The measurements conducted confirmed agreement with the calculated results within the maximum error limit of +-10%. The results of calculation and measurements are shown in graphs

  5. Particle in cell simulation of laser-accelerated proton beams for radiation therapy

    International Nuclear Information System (INIS)

    In this article we present the results of particle in cell (PIC) simulations of laser plasma interaction for proton acceleration for radiation therapy treatments. We show that under optimal interaction conditions protons can be accelerated up to relativistic energies of 300 MeV by a petawatt laser field. The proton acceleration is due to the dragging Coulomb force arising from charge separation induced by the ponderomotive pressure (light pressure) of high-intensity laser. The proton energy and phase space distribution functions obtained from the PIC simulations are used in the calculations of dose distributions using the GEANT Monte Carlo simulation code. Because of the broad energy and angular spectra of the protons, a compact particle selection and beam collimation system will be needed to generate small beams of polyenergetic protons for intensity modulated proton therapy

  6. Hydrogel wound dressing preparation at the laboratory scale by using electron beam and gamma radiation

    International Nuclear Information System (INIS)

    The present work describes the preparation of hydrogel based on cross-linked networks of poly (N-vinylpirrolidone), PVP, with polyethyleneglicol and agar with 90% water and PVP nancomposites with a synthetic nanoclay, Laponite XLG, for use as burn dressings. These systems were obtained in two ways: using gamma Co-60 and electron beam radiation. The gelation obtained dose was Dg= 1.72 kGy. The elastic modulus of hydrogel was independent of the method of irradiation. It was 0.39 MPa for the hydrogel irradiated with gamma Co-60 and 0.38 MPa for electron beam irradiation. The elastic modulus of the nanocomposite membrane was 1.25 MPa, three times higher. These results indicate that the PVP/Laponite XLG nanocomposite hydrogel membrane is the best choice for wound dressing applications due to its high water sorption capacity and its superior mechanical properties.

  7. Inclined-incidence quasi-Fresnel lens for prefocusing of synchrotron radiation x-ray beams

    Science.gov (United States)

    Kagoshima, Yasushi; Takano, Hidekazu; Takeda, Shingo

    2012-10-01

    An inclined-incidence quasi-Fresnel lens made of acrylic resin has been developed for prefocusing in synchrotron radiation x-ray beamlines. By inclining the lens, the grating aspect ratio is large enough for x-ray use. As it operates in transmission mode with negligible beam deflection and offset, little additional equipment is needed to introduce it into existing beamlines. It is fabricated by sheet-press forming, enabling inexpensive mass production. The prototype was able to focus a 730-μm-wide beam to a width of 80 μm with a photon flux density gain of 5.6 at an x-ray energy of 10 keV.

  8. Mission critical operation archiving system using a database for synchrotron radiation beam lines at the Photon Factory

    International Nuclear Information System (INIS)

    The mission critical operation archiving system has been designed and built using the Oracle database for the twenty-two synchrotron radiation beam lines at the 2.5 GeV positron storage ring at the Photon Factory, where X-ray/VUV synchrotron radiation experiments are simultaneously carried out. When any one of beam lines is malfunctioning, neither injecting the 2.5 GeV beam into the storage ring nor operation of the ring is allowed due to the radiation safety reason. The system is designed for critical operation of the synchrotron radiation beam lines to provide a quick recovery from a failure, allowing a long term operation. The system has real-time capability to automatically store the database with all possible operational events of all vacuum valves/shutters and safety interlock signals, and all static operational data, including the pressures of the beam lines and the storage ring, and related operational data which represent the physical behaviors of the beam lines. By retrieving any combination of operational data, the system allows to reproduce the physical behaviors that have occurred in the beam lines. The total number of items to be inspected by the system is over 40 million in order to obtain a correlation between the faulty component and other physical components that suggests the cause of the failure. With the aid of the system, the operator at the control room can easily determine the faulty component, and recover the accelerator component. (author)

  9. Study of the properties of inverted liquid sugar processed with gamma radiation and electron beam

    International Nuclear Information System (INIS)

    Brazil occupies position of prominence in the sugar market and high consumption of this ingredient in the liquid form, in special for the beverages and food industries. The liquid sugar presents advantages in relation to the bulk granulated system such as easiness of the handling and dosage, reduced space for the storage, reduction of the losses, costs and hand of workmanship, improvement of the sanitizing and great possible variation in the ratios of different mixtures of sugars. The inverted liquid sugar is a solution of sucrose, glucose and fructose in water. This ingredient receives this name because during its production it has an inversion of the optic power of rotation of the solution. In the productive process of the inverted sugar some points occur that can generate contamination by microorganisms, so its become important the development of techniques that propitiate the efficient sanitizing of this raw material. This work aims at to consider two alternative techniques of microbiologic control: gamma radiation with source of cobalto-60 and radiation with electron beam. The study was lead in the doses of 5, 10, 20, 30 and 50 kGy. Concentration of sucrose presented in syrup decreased with the radiation indicating the scission of glycosidic linkage in addition with the glucose and fructose formation, generating the increase in solids soluble. The acid compounds formation occurred, confirmed by the reduction of pH, that it was proportional with the increase of the radiation dose. The biggest doses had provoked change of color in the syrup by the long molecular chain polymers formation. Viscosity in the samples processed by gamma radiation increased in relation to the control, indicating the prevalence of polymerization of molecules, whereas in the radiation with electron beam the polymerization was only observed in the sample that received the dose of 50 kGy, In the sensorial analysis, the judges had pointed significant difference (5%) in the flavor among

  10. A method of determining narrow energy spread electron beams from a laser plasma wakefield accelerator using undulator radiation

    International Nuclear Information System (INIS)

    In this paper a new method of determining the energy spread of a relativistic electron beam from a laser-driven plasma wakefield accelerator by measuring radiation from an undulator is presented. This could be used to determine the beam characteristics of multi-GeV accelerators where conventional spectrometers are very large and cumbersome. Simultaneous measurement of the energy spectra of electrons from the wakefield accelerator in the 55-70 MeV range and the radiation spectra in the wavelength range of 700-900 nm of synchrotron radiation emitted from a 50 period undulator confirm a narrow energy spread for electrons accelerated over the dephasing distance where beam loading leads to energy compression. Measured energy spreads of less than 1% indicates the potential of using a wakefield accelerator as a driver of future compact and brilliant ultrashort pulse synchrotron sources and free-electron lasers that require high peak brightness beams.

  11. Measurement of therapeutic photon beams-induced Cerenkov radiation generated in PMMA- and PS-based plastic optical fibers

    Science.gov (United States)

    Lee, Bongsoo; Shin, Sang Hun; Yoo, Wook Jae; Jang, Kyoung Won

    2016-07-01

    In this study, we characterized Cerenkov radiation generated in polystyrene (PS)- and polymethyl methacrylate (PMMA)-based plastic optical fibers (POFs) to select an adequate optical fiber for producing Cerenkov radiation. To determine the relationship between the absorbed dose and the intensity of Cerenkov radiation, we calculated the energy depositions of photon beams and fluxes of electrons inducing Cerenkov radiation using the Monte Carlo N-Particle eXtended code. Also, intensities of Cerenkov radiation generated in PS- and PMMA-based POFs were measured as functions of dose rate and monitor unit. At last, therapeutic photon beams-induced Cerenkov radiation in PS- and PMMA-based POFs was measured according to depths of solid water phantom.

  12. Effect of Photon Beam Energy, Gold Nanoparticle Size and Concentration on the Dose Enhancement in Radiation Therapy

    Directory of Open Access Journals (Sweden)

    Nahideh Gharehaghaji

    2013-02-01

    Full Text Available Introduction: Gold nanoparticles have been used as radiation dose enhancing materials in recent investigations. In the current study, dose enhancement effect of gold nanoparticles on tumor cells was evaluated using Monte Carlo (MC simulation. Methods: We used MCNPX code for MC modeling in the current study. A water phantom and a tumor region with a size of 1×1×1 cm3 loaded with gold nanoparticles were simulated. The macroscopic dose enhancement factor was calculated for gold nanoparticles with sizes of 30, 50, and 100 nm. Also, we simulated different photon beams including mono-energetic beams (50-120 keV, a Cobalt-60 beam, 6 & 18 MV photon beams of a conventional linear accelerator. Results: We found a dose enhancement factor (DEF of from 1.4 to 3.7 for monoenergetic kilovoltage beams, while the DEFs for megavoltage beams were negligible and less than 3% for all GNP sizes and concentrations. The optimum energy for higher DEF was found to be the 90 keV monoenergetic beam. The effect of GNP size was not considerable, but the GNP concentration had a substantial impact on achieved DEF in GNP-based radiation therapy. Conclusion: The results were in close agreement with some previous studies considering the effect of photon energy and GNP concentration on observed DEF. Application of GNP-based radiation therapy using kilovoltage beams is recommended.

  13. Enhancement of terahertz radiation power from a prebunched electron beam using helical wiggler and ion-channel guiding

    Science.gov (United States)

    Hasanbeigi, A.; Mehdian, H.; Gomar, P.

    2015-12-01

    The generation of coherent Terahertz (THz) radiation from the interaction of a bunched relativistic electron beam with helical wiggler pumped is studied on a basis of fluid model. The relativistic electron beam, modulated by two laser beams, propagates through a helical wiggler with ion-channel guiding. Numerical results show that the Terahertz power increases monotonically with the increasing ion-channel frequency up to a critical point corresponding to the increase in the transverse velocity as the resonance (at ω i ≅ β | | ) is approached. The maximum THz power increases with the increasing ion-channel density, the axial velocity, and the radius of the injected beam.

  14. Noncoplanar Beam Angle Class Solutions to Replace Time-Consuming Patient-Specific Beam Angle Optimization in Robotic Prostate Stereotactic Body Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: To investigate development of a recipe for the creation of a beam angle class solution (CS) for noncoplanar prostate stereotactic body radiation therapy to replace time-consuming individualized beam angle selection (iBAS) without significant loss in plan quality, using the in-house “Erasmus-iCycle” optimizer for fully automated beam profile optimization and iBAS. Methods and Materials: For 30 patients, Erasmus-iCycle was first used to generate 15-, 20-, and 25-beam iBAS plans for a CyberKnife equipped with a multileaf collimator. With these plans, 6 recipes for creation of beam angle CSs were investigated. Plans of 10 patients were used to create CSs based on the recipes, and the other 20 to independently test them. For these tests, Erasmus-iCycle was also used to generate intensity modulated radiation therapy plans for the fixed CS beam setups. Results: Of the tested recipes for CS creation, only 1 resulted in 15-, 20-, and 25-beam noncoplanar CSs without plan deterioration compared with iBAS. For the patient group, mean differences in rectum D1cc, V60GyEq, V40GyEq, and Dmean between 25-beam CS plans and 25-beam plans generated with iBAS were 0.2 ± 0.4 Gy, 0.1% ± 0.2%, 0.2% ± 0.3%, and 0.1 ± 0.2 Gy, respectively. Differences between 15- and 20-beam CS and iBAS plans were also negligible. Plan quality for CS plans relative to iBAS plans was also preserved when narrower planning target volume margins were arranged and when planning target volume dose inhomogeneity was decreased. Using a CS instead of iBAS reduced the computation time by a factor of 14 to 25, mainly depending on beam number, without loss in plan quality. Conclusions: A recipe for creation of robust beam angle CSs for robotic prostate stereotactic body radiation therapy has been developed. Compared with iBAS, computation times decreased by a factor 14 to 25. The use of a CS may avoid long planning times without losses in plan quality

  15. Noncoplanar Beam Angle Class Solutions to Replace Time-Consuming Patient-Specific Beam Angle Optimization in Robotic Prostate Stereotactic Body Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, Linda, E-mail: l.rossi@erasmusmc.nl; Breedveld, Sebastiaan; Aluwini, Shafak; Heijmen, Ben

    2015-07-15

    Purpose: To investigate development of a recipe for the creation of a beam angle class solution (CS) for noncoplanar prostate stereotactic body radiation therapy to replace time-consuming individualized beam angle selection (iBAS) without significant loss in plan quality, using the in-house “Erasmus-iCycle” optimizer for fully automated beam profile optimization and iBAS. Methods and Materials: For 30 patients, Erasmus-iCycle was first used to generate 15-, 20-, and 25-beam iBAS plans for a CyberKnife equipped with a multileaf collimator. With these plans, 6 recipes for creation of beam angle CSs were investigated. Plans of 10 patients were used to create CSs based on the recipes, and the other 20 to independently test them. For these tests, Erasmus-iCycle was also used to generate intensity modulated radiation therapy plans for the fixed CS beam setups. Results: Of the tested recipes for CS creation, only 1 resulted in 15-, 20-, and 25-beam noncoplanar CSs without plan deterioration compared with iBAS. For the patient group, mean differences in rectum D{sub 1cc}, V{sub 60GyEq}, V{sub 40GyEq}, and D{sub mean} between 25-beam CS plans and 25-beam plans generated with iBAS were 0.2 ± 0.4 Gy, 0.1% ± 0.2%, 0.2% ± 0.3%, and 0.1 ± 0.2 Gy, respectively. Differences between 15- and 20-beam CS and iBAS plans were also negligible. Plan quality for CS plans relative to iBAS plans was also preserved when narrower planning target volume margins were arranged and when planning target volume dose inhomogeneity was decreased. Using a CS instead of iBAS reduced the computation time by a factor of 14 to 25, mainly depending on beam number, without loss in plan quality. Conclusions: A recipe for creation of robust beam angle CSs for robotic prostate stereotactic body radiation therapy has been developed. Compared with iBAS, computation times decreased by a factor 14 to 25. The use of a CS may avoid long planning times without losses in plan quality.

  16. Tailoring of Highly Intense THz Radiation Through High Brightness Electron Beams Longitudinal Manipulation

    Directory of Open Access Journals (Sweden)

    Flavio Giorgianni

    2016-02-01

    Full Text Available The ultra-short electron beams, produced through the velocity bunching compression technique at the SPARC_LAB test Facility (Frascati, Italy, are used to produce Coherent Transition Radiation in the terahertz (THz range. This paper reports on the main features of this THz source, which have a spectral coverage up to 5 THz, a pulse duration down to 100 fs, and an energy per pulse on the order of tens of μJ. These figures of merits open the possibility to apply this source for nonlinear and THz pump-probe experiments in Solid-State Physics and material science.

  17. Quality control beam of radiation through imaging system using a flat panel (ILD)

    International Nuclear Information System (INIS)

    The daily quality checks of the accelerator include, among others, checks of the daily calibration, symmetry and uniformity of the radiation beam. Usually verification systems daily are used for this purpose, which employ arrays of detectors of solid-state or ionization chambers. This paper intends to carry out the control of quality through the irradiation of a number of fields in the portal imaging system and its subsequent analysis in software's own creation, as well as the comparison of results with the daily verification system. (Author)

  18. Microwave radiation power of relativistic electron beam with virtual cathode in the external magnetic field

    Science.gov (United States)

    Kurkin, S. A.; Hramov, A. E.; Koronovskii, A. A.

    2013-07-01

    The study of the output power of the electromagnetic radiation of the relativistic electron beam (REB) with virtual cathode in the presence of external magnetic field has been found out. The typical dependencies of the output microwave power of the vircator versus external magnetic field have been analyzed by means of 3D electromagnetic simulation. It has been shown that the power of vircator demonstrates several maxima with external magnetic field growth. The characteristic features of the power behavior are determined by the conditions of the virtual cathode formation in the presence of the external transversal magnetic field and the REB self-magnetic fields.

  19. Microwave radiation power of relativistic electron beam with virtual cathode in the external magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Kurkin, S. A.; Hramov, A. E.; Koronovskii, A. A. [Saratov State University, Astrakhanskaja 83, Saratov 410012 (Russian Federation); Saratov State Technical University, Politechnicheskaja 77, Saratov 410028 (Russian Federation)

    2013-07-22

    The study of the output power of the electromagnetic radiation of the relativistic electron beam (REB) with virtual cathode in the presence of external magnetic field has been found out. The typical dependencies of the output microwave power of the vircator versus external magnetic field have been analyzed by means of 3D electromagnetic simulation. It has been shown that the power of vircator demonstrates several maxima with external magnetic field growth. The characteristic features of the power behavior are determined by the conditions of the virtual cathode formation in the presence of the external transversal magnetic field and the REB self-magnetic fields.

  20. Detection of Cherenkov radiation: the inverse problem to generation of nondiffracting beams

    Czech Academy of Sciences Publication Activity Database

    Miler, Miroslav; Pala, Jan

    2003-01-01

    Roč. 33, 2-3 (2003), s. 307-313. ISSN 0078-5466. [Polish-Czech-Slovak Optica l Conference on Wave and Quantum Aspects of Contemporary Optics PCS /13./. Krzyzowa, 09.09.2002-13.09.2002] R&D Projects: GA ČR GA102/01/0429 Institutional research plan: CEZ:AV0Z2067918 Keywords : Cherenkov radiation * holographic optica l elements * laser beams * diffraction Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 0.221, year: 2003

  1. Multicomponent measurements of the Jefferson Lab energy recovery linac electron beam using optical transition and diffraction radiation

    Science.gov (United States)

    Holloway, M. A.; Fiorito, R. B.; Shkvarunets, A. G.; O'Shea, P. G.; Benson, S. V.; Douglas, D.; Evtushenko, P.; Jordan, K.

    2008-08-01

    High brightness electron accelerators, such as energy recovery linacs (ERL), often have complex particle distributions that can create difficulties in beam transport as well as matching to devices such as wigglers used to generate radiation from the beam. Optical transition radiation (OTR), OTR interferometry (OTRI), and optical diffraction-transition radiation interferometry (ODTRI) have proven to be effective tools for diagnosing both the spatial and angular distributions of charged particle beams. OTRI and ODTRI have been used to measure rms divergences, and optical transverse phase space mapping has been demonstrated using OTRI. In this work we present the results of diagnostic experiments using OTR and optical diffraction radiation conducted at the Jefferson Laboratory’s 115 MeV ERL which show the presence of two separate components within the beam’s spatial and angular distributions. By assuming a correlation between the spatial and angular features, we estimate an rms emittance value for each of the two components.

  2. Influence of nuclear radiation and laser beams on optical fibers and components

    Directory of Open Access Journals (Sweden)

    Pantelić Slađana N.

    2011-01-01

    Full Text Available The influence of nuclear radiation and particles has been the object of investigation for a long time. For new materials and systems the research should be continued. Human activities in various environments, including space, call for more detailed research. The role of fibers in contemporary communications, medicine, and industry increases. Fibers, their connections and fused optics components have one type of tasks - the transmission of information and power. The other type of tasks is reserved for fiber lasers: quantum generators and amplifiers. The third type of tasks is for fiber sensors, including high energy nuclear physics. In this paper we present some chosen topics in the mentioned areas as well as our experiments with nuclear radiation and laser beams to fiber and bulk materials of various nature (glass, polymer, metallic, etc..

  3. Present status of study on development of materials resistant to radiation and beam impact

    International Nuclear Information System (INIS)

    Pulsed spallation neutron sources for the materials structure science are severely influenced by beam impact and radiation damage. We have developed the materials strong to these influence since 2004. In this paper, recent topics are described concerning the development of intergranular corrosion (IGC)-resistant austenitic stainless steel for target vessel and window, radiation-resistant ultra-fine grained tungsten materials (W-TiC) for a solid target, CrN film on a tungsten target by means of a molten-salt method, surface treatment of stainless steel for pitting damage in mercury target. Bubble behavior at the interface of mercury and window glass was also observed to clarify the phenomenon of the pitting damage

  4. Preparation and characterization of polyethylene glycol diacrylate microgels using electron beam radiation

    Energy Technology Data Exchange (ETDEWEB)

    Hamzah, Mohd Yusof [Makmal Nanoteknologi, Bahagian Teknologi Sinaran (Malaysia); Isa, Naurah Mat; Napia, Liyana M. Ali [ALURTRON, Bahagian Kemudahan Iradiasi, Malaysian Nuclear Agency, 43000, Kajang, Selangor (Malaysia)

    2014-02-12

    The use of microemulsion in the development of nanosized gels based on polyethylene glycol diacrylate (PEGDA) is demonstrated. PEGDA was solubilized in n-heptane with use of sodium docusate (AOT) at 0.15M concentration to form reverse micelles. These micelles were than irradiated at 5, 10, 15, 20 and 25 kGy using electron beam (EB) to crosslink the entrapped polymer in the micelles. Ionizing radiation was imparted to the emulsions to generate crosslinking reaction in the micelles formed. The nanosized gels were evaluated in terms of particle diameter using dynamic light scattering (DLS) and the images of the nanosized gels were studied using transmission electron microscopy (TEM). Results show that the size and shape of the particles are influenced by concentration of PEGDA and radiation dose. This study showed that this method can be utilized to produce nanosized gels.

  5. Stereotactic body radiation therapy for liver tumours using flattening filter free beam: dosimetric and technical considerations

    International Nuclear Information System (INIS)

    To report the initial institute experience in terms of dosimetric and technical aspects in stereotactic body radiation therapy (SBRT) delivered using flattening filter free (FFF) beam in patients with liver lesions. From October 2010 to September 2011, 55 consecutive patients with 73 primary or metastatic hepatic lesions were treated with SBRT on TrueBeam using FFF beam and RapidArc technique. Clinical target volume (CTV) was defined on multi-phase CT scans, PET/CT, MRI, and 4D-CT. Dose prescription was 75 Gy in 3 fractions to planning target volume (PTV). Constraints for organs at risk were: 700 cc of liver free from the 15 Gy isodose, Dmax < 21 Gy for stomach and duodenum, Dmax < 30 Gy for heart, D0.1 cc < 18 Gy for spinal cord, V15 Gy < 35% for kidneys. The dose was downscaled in cases of not full achievement of dose constraints. Daily cone beam CT (CBCT) was performed. Forty-three patients with a single lesion, nine with two lesions and three with three lesions were treated with this protocol. Target and organs at risk objectives were met for all patients. Mean delivery time was 2.8 ± 1.0 min. Pre-treatment plan verification resulted in a Gamma Agreement Index of 98.6 ± 0.8%. Mean on-line co-registration shift of the daily CBCT to the simulation CT were: -0.08, 0.05 and -0.02 cm with standard deviations of 0.33, 0.39 and 0.55 cm in, vertical, longitudinal and lateral directions respectively. SBRT for liver targets delivered by means of FFF resulted to be feasible with short beam on time

  6. Absolute power scaling measurements of Electromagnetic radiation at 2ω /sub uh/ generated by steady state colliding electron beams

    International Nuclear Information System (INIS)

    Space physics data indicate Electromagnetic (EM) emission correlated with the existence of electron beams in solar and planetary sources. The EM power is too large to be produced by linear plasma production mechanisms, suggesting that non-linear beam processes can coherently, enhance the generation of EM radiation. Steady state counterstreaming electron beams are produced in a triple plasma device, where they collide in a filament discharge target plasma. Neutral pressure is low (5 x 10-5 Torr), with background target density, n /sub e/ less than or equal to 1010 cm-3 and electron temperature T /sub e/ less than or equal to 4 eV . Beams are grid extracted from sources and collimated with a small axial magnetic field (B /sub o/ less than or equal to 10 Gauss). Beam density is n /sub b/ less than or equal to 108 cm-3 and beam energy is E /sub b/ < 150 eV. Plasma ions with varying masses such as He+, Ar+, Xe+ are used. Diagnostics are carried out with electrostatic probes and absolutely calibrated single turn Faraday shielded loop antennae. When counterstreaming electron beams are allowed to collide in the target, steady state electrostatic and electromagnetic disturbances are observed respectively at the upper hybrid frequency and the first harmonic. The colliding beam EM radiation power is seen to be greatly enhanced over that of the single beam case

  7. Angular dependence of OSL commercial detectors in standard beta radiation beams

    International Nuclear Information System (INIS)

    Full text: Optical stimulated luminescence (OSL) is a very successful dosimetry technique, in particular using the Al2O3:C crystals as dosimeter. This detector has become the main OSL material as a personal dosimeter. Commercial dosimeters of Al2O3:C have been developed and tested; however, most of the tests have been performed with gamma beams. Beta radiation dosimetry might be performed with Al2O3:C detectors, if the crystals are sufficient thin to avoid the radiation attenuation. The dosimeter thickness is also important to allow a satisfactory accuracy of the measured dose, despite the incidence radiation angle or the beta energy. Previous studies show that the Al2O3:C dosimeters present a very high energy dependence that can be minimized by using filters. This work aims to compare the angular dependence of commercial Al2O3:C dosimeters with and without the filters used to minimize the beta energy dependence of Al2O3:C, when the detectors were exposed to standard beta beams. The beta irradiations of the OSL detectors were performed using the beta secondary standard system of the Calibration Laboratory at IPEN, with 90Sr + 90Y, 85Kr and 147Pm sources, manufactured by Buchler GmbH and Co, Germany, calibrated by the primary standard laboratory Physikalisch-Technische Bundesanstalt (PTB), Germany. The OSL measurements were evaluated using a microStar reader and software of Landauer. The angular dependence was determined by using a goniometer. The incident radiation angle was varied from 0 deg to 180 deg. The results show that that the angular dependence curves present similar behavior, despite the use of filters

  8. Evaluation of toxicity reduction of sodium dodecyl sulfate submitted to electron beam radiation

    International Nuclear Information System (INIS)

    Surfactants, as detergent active substances, are an important source of pollution causing biological adverse effects to aquatic organisms. Several data have been showing ecological disturbance due to the high concentration of surfactants on receiving waters and on wastewater treatment plants. Ionizing radiation has been proved as an effective technology to decompose organic substances and few papers have included ecotoxicological aspects. This paper shows the reduction of acute toxicity of a specific surfactant, sodium dodecyl sulfate (SDS), when diluted in distilled water and submitted to electron beam radiation. The study included two test-organisms, the marine bacteria Vibrio fischeri and the crustacean Daphnia similis. Radiation processing resulted in an important acute toxicity removal for both assays, which can be summarized between 70% and 96%, using 3.0, 6.0, 9.0 and 12.0 kGy as radiation doses. Nevertheless, lower doses demonstrated better effect than 9.0 and 12.0 kGy and the bacterium assay was more sensitive to SDS than crustacean assay

  9. Evaluation of kinetic parameters of PAN fibre modified by electron beam radiation

    International Nuclear Information System (INIS)

    Carbon fibers used for structural application are about 90% based on polyacrylonitrile (PAN) precursors due to their physical and mechanical properties. The thermal process is the conventional way to obtain a carbon fiber from PAN precursors. However, the use of ionizing radiation is given as an alternative technology to improve the physical and mechanical properties of the resulting carbon fiber. The aim of this paper was to obtain kinetic parameters (activation energy, conversion and isoconversion data) from DSC curves of PAN fibers irradiated with electron beam (EB) at different doses using the software Model Free Kinetics. The EB irradiation doses applied were: 0.2; 0.4; 0.6; 0.8; 1.0 and 1.2 MGy. The effect of ionizing radiation was evaluated by the thermal behavior of PAN precursors studied by Differential Scanning Calorimetry (DSC), which presents an exothermic peak in the range of 200 deg C to 400 deg C, depending on the experimental conditions of the DSC measurements. The obtained results showed that non-irradiated PAN fiber needs higher temperatures or longer reaction times to reach the same conversion degrees of the irradiated PAN fibers. Among the irradiated fibers, the reaction times decrease as a function of the radiation dose applied. However, the most important changes were observed for doses up to 0.4 MGy. The experimental results indicate that the EB radiation induces modification in the PAN fibers, which became them more liable in the oxidation process. (author)

  10. Ion beam characterization of advanced luminescent materials for application in radiation effects microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Branson, J.V., E-mail: jvbrans@sandia.gov [Sandia National Laboratories, P.O. Box 5800 MS 1056, Albuquerque, NM 87185-1056 (United States); Hattar, K. [Sandia National Laboratories, P.O. Box 5800 MS 1056, Albuquerque, NM 87185-1056 (United States); Rossi, P. [Sandia National Laboratories, P.O. Box 5800 MS 1056, Albuquerque, NM 87185-1056 (United States); Department of Physics of the University of Padua and INFN, via Marzolo 8, 35131 Padua (Italy); Vizkelethy, G.; Powell, C.J. [Sandia National Laboratories, P.O. Box 5800 MS 1056, Albuquerque, NM 87185-1056 (United States); Hernandez-Sanchez, B. [Sandia National Laboratories, P.O. Box 5800 MS 1349, Albuquerque, NM 87185-1349 (United States); Doyle, B.L. [Sandia National Laboratories, P.O. Box 5800 MS 1056, Albuquerque, NM 87185-1056 (United States)

    2011-10-15

    The ion photon emission microscope (IPEM) is a technique developed at Sandia National Laboratories (SNL) to study radiation effects in integrated circuits with high energy, heavy ions, such as those produced by the 88' cyclotron at Lawrence Berkeley National Laboratory (LBNL). In this method, an ion-luminescent film is used to produce photons from the point of ion impact. The photons emitted due to an ion impact are imaged on a position-sensitive detector to determine the location of a single event effect (SEE). Due to stringent resolution, intensity, wavelength, decay time, and radiation tolerance demands, an engineered material with very specific properties is required to act as the luminescent film. The requirements for this material are extensive. It must produce a high enough induced luminescent intensity so at least one photon is detected per ion hit. The emission wavelength must match the sensitivity of the detector used, and the luminescent decay time must be short enough to limit accidental coincidences. In addition, the material must be easy to handle and its luminescent properties must be tolerant to radiation damage. Materials studied for this application include plastic scintillators, GaN and GaN/InGaN quantum well structures, and lanthanide-activated ceramic phosphors. Results from characterization studies on these materials will be presented; including photoluminescence, cathodoluminescence, ion beam induced luminescence, luminescent decay times, and radiation damage. Results indicate that the ceramic phosphors are currently proving to be the ideal material for IPEM investigations.

  11. One-dimensional carbon nanostructures for terahertz electron-beam radiation

    Science.gov (United States)

    Tantiwanichapan, Khwanchai; Swan, Anna K.; Paiella, Roberto

    2016-06-01

    One-dimensional carbon nanostructures such as nanotubes and nanoribbons can feature near-ballistic electronic transport over micron-scale distances even at room temperature. As a result, these materials provide a uniquely suited solid-state platform for radiation mechanisms that so far have been the exclusive domain of electron beams in vacuum. Here we consider the generation of terahertz light based on two such mechanisms, namely, the emission of cyclotronlike radiation in a sinusoidally corrugated nanowire (where periodic angular motion is produced by the mechanical corrugation rather than an externally applied magnetic field), and the Smith-Purcell effect in a rectilinear nanowire over a dielectric grating. In both cases, the radiation properties of the individual charge carriers are investigated via full-wave electrodynamic simulations, including dephasing effects caused by carrier collisions. The overall light output is then computed with a standard model of charge transport for two particularly suitable types of carbon nanostructures, i.e., zigzag graphene nanoribbons and armchair single-wall nanotubes. Relatively sharp emission peaks at geometrically tunable terahertz frequencies are obtained in each case. The corresponding output powers are experimentally accessible even with individual nanowires, and can be scaled to technologically significant levels using array configurations. These radiation mechanisms therefore represent a promising paradigm for light emission in condensed matter, which may find important applications in nanoelectronics and terahertz photonics.

  12. Evaluation of toxicity reduction of sodium dodecyl sulfate submitted to electron beam radiation

    Science.gov (United States)

    Romanelli, M. F.; Moraes, M. C. F.; Villavicencio, A. L. C. H.; Borrely, S. I.

    2004-09-01

    Surfactants, as detergent active substances, are an important source of pollution causing biological adverse effects to aquatic organisms. Several data have been showing ecological disturbance due to the high concentration of surfactants on receiving waters and on wastewater treatment plants. Ionizing radiation has been proved as an effective technology to decompose organic substances and few papers have included ecotoxicological aspects. This paper shows the reduction of acute toxicity of a specific surfactant, sodium dodecyl sulfate (SDS), when diluted in distilled water and submitted to electron beam radiation. The study included two test-organisms, the marine bacteria Vibrio fischeri and the crustacean Daphnia similis. Radiation processing resulted in an important acute toxicity removal for both assays, which can be summarized between 70% and 96%, using 3.0, 6.0, 9.0 and 12.0 kGy as radiation doses. Nevertheless, lower doses demonstrated better effect than 9.0 and 12.0 kGy and the bacterium assay was more sensitive to SDS than crustacean assay.

  13. Evaluation of toxicity reduction of sodium dodecyl sulfate submitted to electron beam radiation

    Energy Technology Data Exchange (ETDEWEB)

    Romanelli, M.F. E-mail: mfromane@ipen.br; Moraes, M.C.F.; Villavicencio, A.L.C.H.; Borrely, S.I

    2004-10-01

    Surfactants, as detergent active substances, are an important source of pollution causing biological adverse effects to aquatic organisms. Several data have been showing ecological disturbance due to the high concentration of surfactants on receiving waters and on wastewater treatment plants. Ionizing radiation has been proved as an effective technology to decompose organic substances and few papers have included ecotoxicological aspects. This paper shows the reduction of acute toxicity of a specific surfactant, sodium dodecyl sulfate (SDS), when diluted in distilled water and submitted to electron beam radiation. The study included two test-organisms, the marine bacteria Vibrio fischeri and the crustacean Daphnia similis. Radiation processing resulted in an important acute toxicity removal for both assays, which can be summarized between 70% and 96%, using 3.0, 6.0, 9.0 and 12.0 kGy as radiation doses. Nevertheless, lower doses demonstrated better effect than 9.0 and 12.0 kGy and the bacterium assay was more sensitive to SDS than crustacean assay.

  14. Design of a synchrotron radiation detector for the test beam lines at the Superconducting Super Collider Laboratory

    International Nuclear Information System (INIS)

    As part of the particle- and momentum-tagging instrumentation required for the test beam lines of the Superconducting Super Collider (SSC), the synchrotron radiation detector (SRD) was designed to provide electron tagging at momentum above 75 GeV. In a parallel effort to the three test beam lines at the SSC, schedule demands required testing and calibration operations to be initiated at Fermilab. Synchrotron radiation detectors also were to be installed in the NM and MW beam lines at Femilab before the test beam lines at the SSC would become operational. The SRD is the last instrument in a series of three used in the SSC test beam fines. It follows a 20-m drift section of beam tube downstream of the last silicon strip detector. A bending dipole just in of the last silicon strip detector produces the synchrotron radiation that is detected in a 50-mm-square cross section NaI crystal. A secondary scintillator made of Bicron BC-400 plastic is used to discriminate whether it is synchrotron radiation or a stray particle that causes the triggering of the NaI crystal's photo multiplier tube (PMT)

  15. Physiologically gated micro-beam radiation therapy using electronically controlled field emission x-ray source array

    Science.gov (United States)

    Chtcheprov, Pavel; Hadsell, Michael; Burk, Laurel; Ger, Rachel; Zhang, Lei; Yuan, Hong; Lee, Yueh Z.; Chang, Sha; Lu, Jianping; Zhou, Otto

    2013-03-01

    Micro-beam radiation therapy (MRT) uses parallel planes of high dose narrow (10-100 um in width) radiation beams separated by a fraction of a millimeter to treat cancerous tumors. This experimental therapy method based on synchrotron radiation has been shown to spare normal tissue at up to 1000Gy of entrance dose while still being effective in tumor eradication and extending the lifetime of tumor-bearing small animal models. Motion during the treatment can result in significant movement of micro beam positions resulting in broader beam width and lower peak to valley dose ratio (PVDR), and thus can reduce the effectiveness of the MRT. Recently we have developed the first bench-top image guided MRT system for small animal treatment using a high powered carbon nanotube (CNT) x-ray source array. The CNT field emission x-ray source can be electronically synchronized to an external triggering signal to enable physiologically gated firing of x-ray radiation to minimize motion blurring. Here we report the results of phantom study of respiratory gated MRT. A simulation of mouse breathing was performed using a servo motor. Preliminary results show that without gating the micro beam full width at tenth maximum (FWTM) can increase by 70% and PVDR can decrease up to 50%. But with proper gating, both the beam width and PVDR changes can be negligible. Future experiments will involve irradiation of mouse models and comparing histology stains between the controls and the gated irradiation.

  16. Measurement of transverse beam parameters at X-ray diagnostic beamlines in Indus-2 synchrotron radiation source

    International Nuclear Information System (INIS)

    Indus-2 is a 3rd generation synchrotron radiation source at RRCAT, Indore with 2.5 GeV energy and 200 mA beam current. The average beam sizes of electron beam are a few hundred micrometers (∼ 250 μn) in the transverse plane. In Indus-2, various types of diagnostic devices have been installed in the storage ring for the measurement of beam orbit, beam profile, beam current, tune etc. To further enhance the performance of the beam diagnostic system, two diagnostic beamlines have been designed and developed viz. X-ray diagnostic beamline (X-DBL) and visible diagnostic beamline (V- DBL). Beamline BL-24 at 10° port of bending magnet (DP-10) of Indus-2 storage ring has been developed as X-DBL. X-DBL is based on x-ray imaging (8-18 keV) with a pinhole array system. It is primarily used for beam size, beam emittance and beam position measurement. In X-ray diagnostic beamline a LabVIEW based graphical user interface (Gill) has been developed for online image processing and measurement of various beam parameters. Beamline is used routinely for the online measurements of beam sizes, beam emittance and beam stability. Measured data is analyzed to find changes in SR source point parameters under different conditions of the beam operation. In the present optics setting, typical measured beam size (RMS) is 440 ± 20 μnm horizontal and 55 ± 5 μm vertical, and correspondingly typical measured emittance is 155 ± 20 nm rad horizontal and 0.4 ± 0.05 nm rad vertical during the natural decay of beam current from 120 mA to 40 mA. Beam position remains stable within ± 20 μm horizontal and ± 15 μm vertical during the natural decay of beam current in Indus-2. Photon beam position (at 8 m from source point) remains stable within ± 20 μm during this natural decay of beam current. In this paper various measurement results of the beamline are described. (author)

  17. Analysis of X-ray beam parameters used to implement reference radiations for calibrating dosimetric systems for diagnostic radiology

    International Nuclear Information System (INIS)

    Ionizing radiation metrology is the base to achieve reliable dose measurements in all areas; it is also part of the framework of a radiological protection program that requires the use of reliable instruments that comply with standard performance criteria worldwide accepted. The International Electrotechnical Commission (IEC) established the X-ray reference radiations that are recommended to be used for calibrating dosimetric systems for diagnostic dosimetry. In this work, X-ray beam qualities were implemented in the Dosimeter Calibration Laboratory of the Development Centre of Nuclear Technology; the characteristics of the beams were analyzed through the measurement of parameters like inherent tube filtration, beam uniformity; beam field size, energy spectra and peak voltage. The influence of using 99.425% and 99.999% purity filters was also investigated. The first half-value layers and the homogeneity coefficients were measured for the three RQR2, RQR6 and RQR10 IEC beam qualities. An ionization chamber was also calibrated against a standard chamber in all implemented reference radiations and the relevant sources of uncertainties were estimated. Beam parameters were adjusted to comply with IEC standard; the main source of uncertainty during the calibration process was due to the ionization chamber positioning set-up and the purity of the filters did not cause relevant influence on the beam energy spectra. (author)

  18. Intraoperative Electron-Beam Radiation Therapy for Pediatric Ewing Sarcomas and Rhabdomyosarcomas: Long-Term Outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Sole, Claudio V., E-mail: csole@iram.cl [Department of Radiation Oncology, Instituto de Radiomedicina, Santiago (Chile); School of Medicine, Complutense University, Madrid (Spain); Calvo, Felipe A. [School of Medicine, Complutense University, Madrid (Spain); Department of Oncology, Hospital General Universitario Gregorio Marañón, Madrid (Spain); Polo, Alfredo [Service of Radiation Oncology, Hospital Universitario Ramón y Cajal, Madrid (Spain); Cambeiro, Mauricio [Service of Radiation Oncology, Clínica Universidad de Navarra, Pamplona (Spain); Gonzalez, Carmen [School of Medicine, Complutense University, Madrid (Spain); Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid (Spain); Desco, Manuel [School of Medicine, Complutense University, Madrid (Spain); Department of Experimental Surgery and Medicine, Hospital General Universitario Gregorio Marañón, Madrid (Spain); Martinez-Monge, Rafael [Service of Radiation Oncology, Clínica Universidad de Navarra, Pamplona (Spain)

    2015-08-01

    Purpose: To assess long-term outcomes and toxicity of intraoperative electron-beam radiation therapy (IOERT) in the management of pediatric patients with Ewing sarcomas (EWS) and rhabdomyosarcomas (RMS). Methods and Materials: Seventy-one sarcoma (EWS n=37, 52%; RMS n=34, 48%) patients underwent IOERT for primary (n=46, 65%) or locally recurrent sarcomas (n=25, 35%) from May 1983 to November 2012. Local control (LC), overall survival (OS), and disease-free survival were estimated using Kaplan-Meier methods. For survival outcomes, potential associations were assessed in univariate and multivariate analyses using the Cox proportional hazards model. Results: After a median follow-up of 72 months (range, 4-310 months), 10-year LC, disease-free survival, and OS was 74%, 57%, and 68%, respectively. In multivariate analysis after adjustment for other covariates, disease status (P=.04 and P=.05) and R1 margin status (P<.01 and P=.04) remained significantly associated with LC and OS. Nine patients (13%) reported severe chronic toxicity events (all grade 3). Conclusions: A multimodal IOERT-containing approach is a well-tolerated component of treatment for pediatric EWS and RMS patients, allowing reduction or substitution of external beam radiation exposure while maintaining high local control rates.

  19. Radiation therapy with laser-driven accelerated particle beams: physical dosimetry and spatial dose distribution

    International Nuclear Information System (INIS)

    One of the main goals of the Munich Centre for Advanced Photonics (MAP) is the application of laser driven accelerated (LDA) particle beams for radiation therapy. Due to the unique acceleration process ultrashort particle pulses of high intensity (> 107 particles /cm2/ns) are generated, which makes online detection an ambitious task. So far, state of the art detection of laser accelerated ion pulses are non-electronic detectors like radiochromic films (RCF), imaging plates (IP) or nuclear track detectors (e.g. CR39). All these kind of detectors are offline detectors requiring several hours of processing time. For this reason they are not qualified for an application in radiation therapy where quantitative real time detection of the beam is an essential prerequisite. Therefore we are investigating pixel detectors for real time monitoring of LDA particle pulses. First tests of commercially available systems with 8-20 MeV protons are presented. For radiobiological experiments second generation Gafchromic films (EBT2) have been calibrated with protons of 12 and 20 MeV for a dose range of 0.3-10 Gy. Dose verification in proton irradiation of subcutaneous tumours in mice was successfully accomplished using these films.

  20. Multichannel Data Acquisition System comparison for Quality Assurance in external beam radiation therapy

    International Nuclear Information System (INIS)

    Megavoltage photon radiation therapies are widely used in modern cancer treatment. The improvement of the treatment has lead to the need of Quality Assurance (QA) devices to detect malfunctioning or human mistakes during the planning phase and treatment verification. Active electronic devices for 2D or 3D QA in external beam radiotherapy are typically based on analogue/digital mixed signal Data Acquisition Systems (DAS) which are required to have high spatial resolution, large dynamic range, high sensitivity, large numbers of channels and fast real-time capabilities. The Centre of Medical Radiation Physics (CMRP) has developed several multichannel DAS architectures based on different analogue front-ends to suit a wide range of radiotherapy applications. For the purpose of this study, two DAS, with different front-ends, have been equipped with 128 channels and tested in a clinical environment. Data show a good agreement within 1% between the two systems and the ionising chamber currently used for daily QA. - Highlights: • Two multichannels Data Acquisition Systems (DAS A and B) have been designed by the CMRP for Quality Assurance purposes. • The DAS have been tested and compared to ion chamber showing agreement of the results within 1%. • DAS have been used to characterise megavoltage LINAC beam profile and timing performances

  1. Intraoperative Electron-Beam Radiation Therapy for Pediatric Ewing Sarcomas and Rhabdomyosarcomas: Long-Term Outcomes

    International Nuclear Information System (INIS)

    Purpose: To assess long-term outcomes and toxicity of intraoperative electron-beam radiation therapy (IOERT) in the management of pediatric patients with Ewing sarcomas (EWS) and rhabdomyosarcomas (RMS). Methods and Materials: Seventy-one sarcoma (EWS n=37, 52%; RMS n=34, 48%) patients underwent IOERT for primary (n=46, 65%) or locally recurrent sarcomas (n=25, 35%) from May 1983 to November 2012. Local control (LC), overall survival (OS), and disease-free survival were estimated using Kaplan-Meier methods. For survival outcomes, potential associations were assessed in univariate and multivariate analyses using the Cox proportional hazards model. Results: After a median follow-up of 72 months (range, 4-310 months), 10-year LC, disease-free survival, and OS was 74%, 57%, and 68%, respectively. In multivariate analysis after adjustment for other covariates, disease status (P=.04 and P=.05) and R1 margin status (P<.01 and P=.04) remained significantly associated with LC and OS. Nine patients (13%) reported severe chronic toxicity events (all grade 3). Conclusions: A multimodal IOERT-containing approach is a well-tolerated component of treatment for pediatric EWS and RMS patients, allowing reduction or substitution of external beam radiation exposure while maintaining high local control rates

  2. Radiation therapy with laser-driven accelerated particle beams: physical dosimetry and spatial dose distribution

    Energy Technology Data Exchange (ETDEWEB)

    Reinhardt, Sabine; Assmann, Walter [Ludwig-Maximilians Universitaet Muenchen (Germany); Kneschaurek, Peter; Wilkens, Jan [MRI, Technische Universitaet Muenchen (Germany)

    2011-07-01

    One of the main goals of the Munich Centre for Advanced Photonics (MAP) is the application of laser driven accelerated (LDA) particle beams for radiation therapy. Due to the unique acceleration process ultrashort particle pulses of high intensity (> 10{sup 7} particles /cm{sup 2}/ns) are generated, which makes online detection an ambitious task. So far, state of the art detection of laser accelerated ion pulses are non-electronic detectors like radiochromic films (RCF), imaging plates (IP) or nuclear track detectors (e.g. CR39). All these kind of detectors are offline detectors requiring several hours of processing time. For this reason they are not qualified for an application in radiation therapy where quantitative real time detection of the beam is an essential prerequisite. Therefore we are investigating pixel detectors for real time monitoring of LDA particle pulses. First tests of commercially available systems with 8-20 MeV protons are presented. For radiobiological experiments second generation Gafchromic films (EBT2) have been calibrated with protons of 12 and 20 MeV for a dose range of 0.3-10 Gy. Dose verification in proton irradiation of subcutaneous tumours in mice was successfully accomplished using these films.

  3. Ultrasonic Beam Radiation of an A0 Leaky Lamb Wave in a Plate Waveguide Sensor

    International Nuclear Information System (INIS)

    As the sodium coolant of a sodium-cooled fast reactor (SFR) is opaque to light, a conventional visual inspection cannot be used for carrying out an in-service inspection of the internal structures under a sodium level. An ultrasonic wave should be applied for an under-sodium viewing of the internal structures in a reactor vessel. Immersion sensors and waveguide sensors have been applied to the under-sodium visualization. The immersion sensor has a precise imaging capability, but may have high temperature restrictions and an uncertain life. The waveguide sensor has the advantages of a long lifetime and stable application. Recently, a new plate waveguide sensor has been developed for the versatile applications in the under-sodium viewing application. In the plate waveguide sensor, the A0 leaky Lamb wave is utilized for the long distance propagation and the effective radiation capability in a fluid. And a new technique is presented which is capable of steering an ultrasonic beam of a waveguide sensor without a mechanical movement of the sensor assembly. In this paper, the experimental study of the radiation beam profile of the A0 leaky Lamb wave in a plate waveguide sensor is carried out

  4. Optical dosimetry of radiotherapy beams using Cherenkov radiation: the relationship between light emission and dose

    International Nuclear Information System (INIS)

    Recent studies have proposed that light emitted by the Cherenkov effect may be used for a number of radiation therapy dosimetry applications. There is a correlation between the captured light and expected dose under certain conditions, yet discrepancies have also been observed and a complete examination of the theoretical differences has not been done. In this study, a fundamental comparison between the Cherenkov emission and absorbed dose was explored for x-ray photons, electrons, and protons using both a theoretical and Monte Carlo-based analysis. Based on the findings of where dose correlates with Cherenkov emission, it was concluded that for x-ray photons the light emission would be optimally suited for narrow beam stereotactic radiation therapy and surgery validation studies, for verification of dynamic intensity-modulated and volumetric modulated arc therapy treatment plans in water tanks, near monoenergetic sources (e.g., Co-60 and brachy therapy sources) and also for entrance and exit surface imaging dosimetry of both narrow and broad beams. For electron use, Cherenkov emission was found to be only suitable for surface dosimetry applications. Finally, for proton dosimetry, there exists a fundamental lack of Cherenkov emission at the Bragg peak, making the technique of little use, although post-irradiation detection of light emission from radioisotopes could prove to be useful. (paper)

  5. External beam radiation therapy for the treatment of subretinal neovascularization: experience with 140 patients

    International Nuclear Information System (INIS)

    Purpose/Objectives: Several clinical series with relatively small numbers of patients and short durations of follow-up have demonstrated that external beam radiation may be effective in treating subretinal neovascularization, a major cause of blindness in the U.S. This prospective study evaluates the efficacy of this treatment in a larger cohort of patients with a longer duration of follow-up than any previously reported series. Materials and Methods: One hundred forty patients between the ages of 50 and 96 were enrolled in this study between March 1994 and March 1996. Forty patients had previously undergone laser photocoagulation for subretinal neovascularization at other sites. Pretreatment visual acuity in the irradiated eyes was at least (20(400)). Prior to the initiation of external beam radiation therapy all patients underwent fluorocein angiography and indirect ophthalmoscopy to document the extent of neovascularization. Treatments were administered via single lateral photon beams of 4 - 6 MV energy, angled 5 degree sign - 10 degree sign posteriorly to avoid the anterior segment of the contralateral eye. Seventy-five patients received 1400 - 1500 cGy in 7-8 fractions while the remaining 65 patients received 1800 cGy in 9-10 fractions. Results: Transient epiphora and conjunctival irritation appeared to be more common in patients receiving 1800 cGy as opposed to 1400 - 1500 cGy. All patients underwent repeat ophthalmoscopy and angiography at three month intervals following treatment. Within three months of treatment, we noted regression or stabilization of retinal hemorrhages and exudates in over 85% of patients. Approximately 75% of patients followed for at least six months have maintained within two lines of their pre-treatment visual acuity. There was no significant difference in response to treatment between the 1400 - 1500 cGy and 1800 cGy arms. Conclusion: This study includes more patients with longer follow-up than any previously reported series. It

  6. Partial Breast Radiation Therapy With Proton Beam: 5-Year Results With Cosmetic Outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Bush, David A., E-mail: dbush@llu.edu [Department of Radiation Oncology, Loma Linda University Medical Center, Loma Linda, California (United States); Do, Sharon [Department of Radiation Oncology, Loma Linda University Medical Center, Loma Linda, California (United States); Lum, Sharon; Garberoglio, Carlos [Department of Surgical Oncology, Loma Linda University Medical Center, Loma Linda, California (United States); Mirshahidi, Hamid [Department of Medical Oncology, Loma Linda University Medical Center, Loma Linda, California (United States); Patyal, Baldev; Grove, Roger; Slater, Jerry D. [Department of Radiation Oncology, Loma Linda University Medical Center, Loma Linda, California (United States)

    2014-11-01

    Purpose: We updated our previous report of a phase 2 trial using proton beam radiation therapy to deliver partial breast irradiation (PBI) in patients with early stage breast cancer. Methods and Materials: Eligible subjects had invasive nonlobular carcinoma with a maximal dimension of 3 cm. Patients underwent partial mastectomy with negative margins; axillary lymph nodes were negative on sampling. Subjects received postoperative proton beam radiation therapy to the surgical bed. The dose delivered was 40 Gy in 10 fractions, once daily over 2 weeks. Multiple fields were treated daily, and skin-sparing techniques were used. Following treatment, patients were evaluated with clinical assessments and annual mammograms to monitor toxicity, tumor recurrence, and cosmesis. Results: One hundred subjects were enrolled and treated. All patients completed the assigned treatment and were available for post-treatment analysis. The median follow-up was 60 months. Patients had a mean age of 63 years; 90% had ductal histology; the average tumor size was 1.3 cm. Actuarial data at 5 years included ipsilateral breast tumor recurrence-free survival of 97% (95% confidence interval: 100%-93%); disease-free survival of 94%; and overall survival of 95%. There were no cases of grade 3 or higher acute skin reactions, and late skin reactions included 7 cases of grade 1 telangiectasia. Patient- and physician-reported cosmesis was good to excellent in 90% of responses, was not changed from baseline measurements, and was well maintained throughout the entire 5-year follow-up period. Conclusions: Proton beam radiation therapy for PBI produced excellent ipsilateral breast recurrence-free survival with minimal toxicity. The treatment proved to be adaptable to all breast sizes and lumpectomy cavity configurations. Cosmetic results appear to be excellent and unchanged from baseline out to 5 years following treatment. Cosmetic results may be improved over those reported with photon

  7. Partial Breast Radiation Therapy With Proton Beam: 5-Year Results With Cosmetic Outcomes

    International Nuclear Information System (INIS)

    Purpose: We updated our previous report of a phase 2 trial using proton beam radiation therapy to deliver partial breast irradiation (PBI) in patients with early stage breast cancer. Methods and Materials: Eligible subjects had invasive nonlobular carcinoma with a maximal dimension of 3 cm. Patients underwent partial mastectomy with negative margins; axillary lymph nodes were negative on sampling. Subjects received postoperative proton beam radiation therapy to the surgical bed. The dose delivered was 40 Gy in 10 fractions, once daily over 2 weeks. Multiple fields were treated daily, and skin-sparing techniques were used. Following treatment, patients were evaluated with clinical assessments and annual mammograms to monitor toxicity, tumor recurrence, and cosmesis. Results: One hundred subjects were enrolled and treated. All patients completed the assigned treatment and were available for post-treatment analysis. The median follow-up was 60 months. Patients had a mean age of 63 years; 90% had ductal histology; the average tumor size was 1.3 cm. Actuarial data at 5 years included ipsilateral breast tumor recurrence-free survival of 97% (95% confidence interval: 100%-93%); disease-free survival of 94%; and overall survival of 95%. There were no cases of grade 3 or higher acute skin reactions, and late skin reactions included 7 cases of grade 1 telangiectasia. Patient- and physician-reported cosmesis was good to excellent in 90% of responses, was not changed from baseline measurements, and was well maintained throughout the entire 5-year follow-up period. Conclusions: Proton beam radiation therapy for PBI produced excellent ipsilateral breast recurrence-free survival with minimal toxicity. The treatment proved to be adaptable to all breast sizes and lumpectomy cavity configurations. Cosmetic results appear to be excellent and unchanged from baseline out to 5 years following treatment. Cosmetic results may be improved over those reported with photon

  8. Beam test of novel n-in-p strip sensors for high radiation environment

    International Nuclear Information System (INIS)

    Highly radiation tolerant n-in-p strip sensors have been developed for the high-luminosity LHC (HL-LHC). This paper reports the results of measurements with 392 MeV kinetic energy proton beam at RCNP in December 2011. The data was taken with a new DAQ system consisting of an universal read-out board ‘SEABAS’ and beam tracking telescopes whose spacial resolution is better than 5μm. The aim of this beam test is to evaluate the new 1 cm×1 cm n-in-p miniature sensors before and after 1015 neq cm−2 irradiation. The median charge of un-irradiated sensor is 6.2 fC at full depletion voltage, while the median charge after 1015 neq cm−2 irradiation of the sensor is 4.2 fC. The novel Punch-Through-Protection (PTP) has been implemented in these sensors. The length of active region of the sensor around PTP is observed to be decreased by 12μm in the irradiated sensors at 1015 neq cm−2

  9. Radiation damage of semi-conductor device using micro ion-beam

    Energy Technology Data Exchange (ETDEWEB)

    Nishijima, Toshiji [Electrotechnical Lab., Tsukuba, Ibaraki (Japan)

    2001-02-01

    Ion beam induced charge collection (IBIC) analyzing method using fast micro ion-beam is a very useful technique for observation of interaction of fine solid materials for electronics with incident ions. This method is applied for development of semiconductor devices and investigation of single event upset phenomena (SEU) in an integrated circuit. To study on a basic process of the SEU, high energy ions are irradiated to the following three micro diode devices; silicon junction diode, silicon-on-insulator device (SOI), and SiC Schottky barrier diode. Transient currents induced in the micro diode devices by He{sup +} ion incidence of 2 MeV are measured through a charge sensitive preamplifier and a linear amplifier. The current signals are digitized by an analog to digital converter and measured by using a pulse height analyzer. The micro ion-beam are irradiated within the area of 10 {mu} m{sup 2} on the diode devices with 1-2 particles/ {mu} m{sup 2} by using the IBIC technique. Radiation damage of the diodes can be measured with the IBIC current pulse height. SiC Schottky barrier diode is unstable on the ion irradiation in comparison with Si junction diode and SOI junction diode. The SOI junction diode is stable within the range of irradiation rate, 3.7E+10 - 3.7E+12 ions/cm{sup 2}. (M. Suetake)

  10. Improving the Fermilab Booster Notching Efficiency, Beam Losses and Radiation Levels

    CERN Document Server

    Rakhno, I L; Mokhov, N V; Sidorov, V I; Tropin, I S

    2012-01-01

    Currently a fast vertical 1.08-m long kicker (notcher) located in the Fermilab Booster Long-5 straight section is used to remove 3 out of 84 circulating bunches after injection to generate an abort gap. With magnetic field of 72.5 Gauss it removes only 87% of the 3-bunch intensity at 400 MeV, with 75% loss on pole tips of the focusing Booster magnets, 11% on the Long-6 collimators, and 1% in the rest of the ring. We propose to improve the notching efficiency and reduce beam loss in the Booster by using two horizontal kickers in the Long-12 section. The STRUCT calculations show that using such horizontal notchers, one can remove up to 99% of the 3-bunch intensity at 400-700 MeV, directing 96% of it to a new beam dump at the Long-13 section. This fully decouples notching and collimation. The beam dump absorbs most of the impinging proton energy in its jaws. The latter are encapsulated into an appropriate radiation shielding that reduces impact on the machine components, personnel and environment to the tolerabl...

  11. External beam radiation therapy followed by high-dose-rate brachytherapy for inoperable superficial esophageal carcinoma

    International Nuclear Information System (INIS)

    Purpose: The aim of this study was to retrospectively evaluate the feasibility, efficacy, and tolerance of external beam radiotherapy followed by high-dose-rate brachytherapy in inoperable patients with superficial esophageal cancer. Patients and Methods: From November 1992 to May 1999, 66 patients with superficial esophageal cancer were treated with exclusive radiotherapy. The median age was 60 years (range, 41-85). Fifty-three percent of them were ineligible for surgery owing to synchronous or previously treated head-and-neck cancer. Most of the patients (n = 49) were evaluated with endoscopic ultrasonography (EUS) or computed tomography (CT). The mean doses of external beam radiotherapy and high-dose rate brachytherapy were 57.1 Gy (±4.83) and 8.82 Gy (±3.98), respectively. The most frequently used regimen was 60 Gy followed by 7 Gy at 5 mm depth in two applications. Results: Among patients evaluated with EUS or CT, the complete response rate was 98%. The 3-, 5-, and 7-year survival rates were 57.9%, 35.6%, and 26.6%, respectively. Median overall survival was 3.8 years. The 5-year relapse-free survival and cause-specific survival were 54.6% and 76.9%. The 5-year overall, relapse-free, and cause-specific survival of the whole population of 66 patients was 33%, 53%, and 77%, respectively. Local failure occurred in 15 of 66 patients; 6 were treated with brachytherapy. Severe late toxicity (mostly esophageal stenosis) rated according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer scale occurred in 6 of 66 patients (9%). Conclusion: This well tolerated regimen may be a therapeutic alternative for inoperable patients with superficial esophageal cancer. Only a randomized study could be able to check the potential benefit of brachytherapy after external beam radiation in superficial esophageal cancer

  12. Radiation environment simulations at the Tevatron, studies of the beam profile and measurement of the Bc meson mass

    Energy Technology Data Exchange (ETDEWEB)

    Nicolas, Ludovic Y.

    2005-09-01

    The description of a computer simulation of the CDF detector at Fermilab and the adjacent accelerator parts is detailed, with MARS calculations of the radiation background in various elements of the model due to the collision of beams and machine-related losses. Three components of beam halo formation are simulated for the determination of the principal source of radiation background in CDF due to beam losses. The effect of a collimator as a protection for the detector is studied. The simulation results are compared with data taken by a CDF group. Studies of a 150 GeV Tevatron proton beam are performed to investigate the transverse diffusion growth and distribution. A technique of collimator scan is used to scrape the beam under various experimental conditions, and computer programs are written for the beam reconstruction. An average beam halo growth speed is given and the potential of beam tail reconstruction using the collimator scan is evaluated. A particle physics analysis is conducted in order to detect the B{sub c} {yields} J/{psi}{pi} decay signal with the CDF Run II detector in 360 pb{sup -1} of data. The cut variables and an optimization method to determine their values are presented along with a criterion for the detection threshold of the signal. The mass of the B{sub c} meson is measured with an evaluation of the significance of the signal.

  13. A Novel Approach to Postmastectomy Radiation Therapy Using Scanned Proton Beams

    International Nuclear Information System (INIS)

    Purpose: Postmastectomy radiation therapy (PMRT), currently offered at Massachusetts General Hospital, uses proton pencil beam scanning (PBS) with intensity modulation, achieving complete target coverage of the chest wall and all nodal regions and reduced dose to the cardiac structures. This work presents the current methodology for such treatment and the ongoing effort for its improvements. Methods and Materials: A single PBS field is optimized to ensure appropriate target coverage and heart/lung sparing, using an in–house-developed proton planning system with the capability of multicriteria optimization. The dose to the chest wall skin is controlled as a separate objective in the optimization. Surface imaging is used for setup because it is a suitable surrogate for superficial target volumes. In order to minimize the effect of beam range uncertainties, the relative proton stopping power ratio of the material in breast implants was determined through separate measurements. Phantom measurements were also made to validate the accuracy of skin dose calculation in the treatment planning system. Additionally, the treatment planning robustness was evaluated relative to setup perturbations and patient breathing motion. Results: PBS PMRT planning resulted in appropriate target coverage and organ sparing, comparable to treatments by passive scattering (PS) beams but much improved in nodal coverage and cardiac sparing compared to conventional treatments by photon/electron beams. The overall treatment time was much shorter than PS and also shorter than conventional photon/electron treatment. The accuracy of the skin dose calculation by the planning system was within ±2%. The treatment was shown to be adequately robust relative to both setup uncertainties and patient breathing motion, resulting in clinically satisfying dose distributions. Conclusions: More than 25 PMRT patients have been successfully treated at Massachusetts General Hospital by using single-PBS fields

  14. Stereotactic body radiation therapy for liver tumours using flattening filter free beam: dosimetric and technical considerations

    Directory of Open Access Journals (Sweden)

    Mancosu Pietro

    2012-02-01

    Full Text Available Abstract Purpose To report the initial institute experience in terms of dosimetric and technical aspects in stereotactic body radiation therapy (SBRT delivered using flattening filter free (FFF beam in patients with liver lesions. Methods and Materials From October 2010 to September 2011, 55 consecutive patients with 73 primary or metastatic hepatic lesions were treated with SBRT on TrueBeam using FFF beam and RapidArc technique. Clinical target volume (CTV was defined on multi-phase CT scans, PET/CT, MRI, and 4D-CT. Dose prescription was 75 Gy in 3 fractions to planning target volume (PTV. Constraints for organs at risk were: 700 cc of liver free from the 15 Gy isodose, Dmax max 0.1 cc 15 Gy Results Forty-three patients with a single lesion, nine with two lesions and three with three lesions were treated with this protocol. Target and organs at risk objectives were met for all patients. Mean delivery time was 2.8 ± 1.0 min. Pre-treatment plan verification resulted in a Gamma Agreement Index of 98.6 ± 0.8%. Mean on-line co-registration shift of the daily CBCT to the simulation CT were: -0.08, 0.05 and -0.02 cm with standard deviations of 0.33, 0.39 and 0.55 cm in, vertical, longitudinal and lateral directions respectively. Conclusions SBRT for liver targets delivered by means of FFF resulted to be feasible with short beam on time.

  15. A Novel Approach to Postmastectomy Radiation Therapy Using Scanned Proton Beams

    Energy Technology Data Exchange (ETDEWEB)

    Depauw, Nicolas, E-mail: ndepauw@partners.org [Francis H. Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Centre for Medical Radiation Physics, University of Wollongong, New South Wales (Australia); Batin, Estelle; Daartz, Julianne [Francis H. Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Rosenfeld, Anatoly [Centre for Medical Radiation Physics, University of Wollongong, New South Wales (Australia); Adams, Judith; Kooy, Hanne; MacDonald, Shannon; Lu, Hsiao-Ming [Francis H. Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)

    2015-02-01

    Purpose: Postmastectomy radiation therapy (PMRT), currently offered at Massachusetts General Hospital, uses proton pencil beam scanning (PBS) with intensity modulation, achieving complete target coverage of the chest wall and all nodal regions and reduced dose to the cardiac structures. This work presents the current methodology for such treatment and the ongoing effort for its improvements. Methods and Materials: A single PBS field is optimized to ensure appropriate target coverage and heart/lung sparing, using an in–house-developed proton planning system with the capability of multicriteria optimization. The dose to the chest wall skin is controlled as a separate objective in the optimization. Surface imaging is used for setup because it is a suitable surrogate for superficial target volumes. In order to minimize the effect of beam range uncertainties, the relative proton stopping power ratio of the material in breast implants was determined through separate measurements. Phantom measurements were also made to validate the accuracy of skin dose calculation in the treatment planning system. Additionally, the treatment planning robustness was evaluated relative to setup perturbations and patient breathing motion. Results: PBS PMRT planning resulted in appropriate target coverage and organ sparing, comparable to treatments by passive scattering (PS) beams but much improved in nodal coverage and cardiac sparing compared to conventional treatments by photon/electron beams. The overall treatment time was much shorter than PS and also shorter than conventional photon/electron treatment. The accuracy of the skin dose calculation by the planning system was within ±2%. The treatment was shown to be adequately robust relative to both setup uncertainties and patient breathing motion, resulting in clinically satisfying dose distributions. Conclusions: More than 25 PMRT patients have been successfully treated at Massachusetts General Hospital by using single-PBS fields

  16. Radiation retinopathy after external-beam irradiation: Analysis of time-dose factors

    International Nuclear Information System (INIS)

    To investigate the risk of radiation-induced retinopathy according to total radiation dose and fraction size, based on both retorspective and prospectively collected data. Between October 1964 and May 1989, 68 retinae in 64 patients received fractionated external-beam irradiation during the treatment of primary extracranial head and neck tumors. All patients had a minimum of 3 years of ophthalmologic follow-up (range, 3 to 26 years; mean, 9 years; median, 8 years). Twenty-seven eyes in 26 patients developed radiation retinopathy resulting in visual acuity of 20/200 or worse. The mean and median times to the onset of symptoms attributable to retinal ischemia were 2.8 and 2.5 years, respectively. Fourteen of the injured eyes developed rubeosis iridis and/or neovascular glaucoma. Radiation retinopathy was not observed at doses below 45 Gy, but increased steadily in incidence at doses ≥45Gy. In the range of doses between 45 and 55 Gy, there was an increased risk of injury among patients who received doses per fraction of ≥1.9Gy (p - .09). There was also a trend toward increased risk of injury among patients who received chemotherapy (two of two vs. four of ten in the 45-51 Gy range; p - .23). The lowest dose associated with retinopathy was 45 Gy delivered to a diabetic patient by twice-a-day fractionation. The data did not suggest an increased risk of radiation retinopathy with increasing age. The current study suggests the importance of total dose as well as dose per fraction, and adds support to a small body of literature suggesting that patients with diabetes mellitus or who receive chemotherapy are at increased risk of injury. A sigmoid dose-response curve is constructed from our current data and data from the literature. 36 refs., 5 figs., 4 tabs

  17. Design concept for a direct water-cooled silicon crystal for use in a high-power synchrotron radiation beam

    International Nuclear Information System (INIS)

    The onset of high-power Synchrotron Radiation beams, now available at several of the Synchrotron Radiation facilities, has resulted in a search for new ways on how to handle the increased thermal load on optical components that are directly exposed to these beams. This report examines one possible way of the direct water-cooling of a silicon crystal as used in monochromators and how to get the water to the crystal with the least possible strain on the crystal. Suggestions are made on how to mount the crystal assembly in an experimental setup, so that physical properties of the crystal can be measured during direct exposure to a suitable high-power Synchrotron Radiation beam. Ways of making small correction movements to the crystal in two directions are outlined. (author)

  18. Whole acute toxicity removal from industrial and domestic effluents treated by electron beam radiation: emphasis on anionic surfactants

    International Nuclear Information System (INIS)

    Electron beam radiation has been applied to improve real industrial and domestic effluents received by Suzano wastewater treatment plant. Radiation efficacy has been evaluated as toxicity reduction, using two biological assays. Three sites were sampled and submitted for toxicity assays, anionic surfactant determination and electron beam irradiation. This paper shows the reduction of acute toxicity for both test-organisms, the marine bacteria Vibrio fischeri and the crustacean Daphnia similis. The raw toxic effluents exibitted from 0.6 ppm up to 11.67 ppm for anionic surfactant before being treated by the electron beam. Radiation processing resulted in reduction of the acute toxicity as well as surfactant removal. The final biological effluent was in general less toxic than other sites but the presence of anionic surfactants was evidenced

  19. Whole acute toxicity removal from industrial and domestic effluents treated by electron beam radiation: emphasis on anionic surfactants

    Energy Technology Data Exchange (ETDEWEB)

    Moraes, M.C.F. E-mail: mariacristinafm@uol.com.br; Romanelli, M.F; Sena, H.C.; Pasqualini da Silva, G.; Sampa, M.H.O.; Borrely, S.I

    2004-10-01

    Electron beam radiation has been applied to improve real industrial and domestic effluents received by Suzano wastewater treatment plant. Radiation efficacy has been evaluated as toxicity reduction, using two biological assays. Three sites were sampled and submitted for toxicity assays, anionic surfactant determination and electron beam irradiation. This paper shows the reduction of acute toxicity for both test-organisms, the marine bacteria Vibrio fischeri and the crustacean Daphnia similis. The raw toxic effluents exibitted from 0.6 ppm up to 11.67 ppm for anionic surfactant before being treated by the electron beam. Radiation processing resulted in reduction of the acute toxicity as well as surfactant removal. The final biological effluent was in general less toxic than other sites but the presence of anionic surfactants was evidenced.

  20. Whole acute toxicity removal from industrial and domestic effluents treated by electron beam radiation: emphasis on anionic surfactants

    Science.gov (United States)

    Moraes, M. C. F.; Romanelli, M. F.; Sena, H. C.; Pasqualini da Silva, G.; Sampa, M. H. O.; Borrely, S. I.

    2004-09-01

    Electron beam radiation has been applied to improve real industrial and domestic effluents received by Suzano wastewater treatment plant. Radiation efficacy has been evaluated as toxicity reduction, using two biological assays. Three sites were sampled and submitted for toxicity assays, anionic surfactant determination and electron beam irradiation. This paper shows the reduction of acute toxicity for both test-organisms, the marine bacteria Vibrio fischeri and the crustacean Daphnia similis. The raw toxic effluents exibitted from 0.6 ppm up to 11.67 ppm for anionic surfactant before being treated by the electron beam. Radiation processing resulted in reduction of the acute toxicity as well as surfactant removal. The final biological effluent was in general less toxic than other sites but the presence of anionic surfactants was evidenced.

  1. The use of intensity-modulated radiation therapy photon beams for improving the dose uniformity of electron beams shaped with MLC

    International Nuclear Information System (INIS)

    Electrons are ideal for treating shallow tumors and sparing adjacent normal tissue. Conventionally, electron beams are collimated by cut-outs that are time-consuming to make and difficult to adapt to tumor shape throughout the course of treatment. We propose that electron cut-outs can be replaced using photon multileaf collimator (MLC). Two major problems of this approach are that the scattering of electrons causes penumbra widening because of a large air gap, and available commercial treatment planning systems (TPSs) do not support MLC-collimated electron beams. In this study, these difficulties were overcome by (1) modeling electron beams collimated by photon MLC for a commercial TPS, and (2) developing a technique to reduce electron beam penumbra by adding low-energy intensity-modulated radiation therapy (IMRT) photons (4 MV). We used blocks to simulate MLC shielding in the TPS. Inverse planning was used to optimize boost photon beams. This technique was applied to a parotid and a central nervous system (CNS) clinical case. Combined photon and electron plans were compared with conventional plans and verified using ion chamber, film, and a 2D diode array. Our studies showed that the beam penumbra for mixed beams with 90 cm source to surface distance (SSD) is comparable with electron applicators and cut-outs at 100 cm SSD. Our mixed-beam technique yielded more uniform dose to the planning target volume and lower doses to various organs at risk for both parotid and CNS clinical cases. The plans were verified with measurements, with more than 95% points passing the gamma criteria of 5% in dose difference and 5 mm for distance to agreement. In conclusion, the study has demonstrated the feasibility and potential advantage of using photon MLC to collimate electron beams with boost photon IMRT fields.

  2. Multiscale registration of planning CT and daily cone beam CT images for adaptive radiation therapy

    International Nuclear Information System (INIS)

    Adaptive radiation therapy (ART) is the incorporation of daily images in the radiotherapy treatment process so that the treatment plan can be evaluated and modified to maximize the amount of radiation dose to the tumor while minimizing the amount of radiation delivered to healthy tissue. Registration of planning images with daily images is thus an important component of ART. In this article, the authors report their research on multiscale registration of planning computed tomography (CT) images with daily cone beam CT (CBCT) images. The multiscale algorithm is based on the hierarchical multiscale image decomposition of E. Tadmor, S. Nezzar, and L. Vese [Multiscale Model. Simul. 2(4), pp. 554-579 (2004)]. Registration is achieved by decomposing the images to be registered into a series of scales using the (BV, L2) decomposition and initially registering the coarsest scales of the image using a landmark-based registration algorithm. The resulting transformation is then used as a starting point to deformably register the next coarse scales with one another. This procedure is iterated at each stage using the transformation computed by the previous scale registration as the starting point for the current registration. The authors present the results of studies of rectum, head-neck, and prostate CT-CBCT registration, and validate their registration method quantitatively using synthetic results in which the exact transformations our known, and qualitatively using clinical deformations in which the exact results are not known.

  3. A study on size effect of carboxymethyl starch nanogel crosslinked by electron beam radiation

    Science.gov (United States)

    Binh, Doan; Pham Thi Thu Hong; Nguyen Ngoc Duy; Nguyen Thanh Duoc; Nguyen Nguyet Dieu

    2012-07-01

    The formation of carboxymethyl starch (CMS) nanogel with 50 nm less particle size was carried out through a radiation crosslinked process on the electron beam (EB) linear accelerator. Changes of intrinsic viscosities and weight averaged molecular weight in the CMS concentration, which ranged from 3 to 10 mg ml-1 in absorbed doses were investigated. There were some new peaks in the 1H NMR spectra of CMS nanogel compared with those of CMS polymer. These results were anticipated that the predominant intramolecular crosslinking of dilute CMS aqueous solution occurred while being exposed to a short intense pulse of ionizing radiation. Hydrodynamic radius (often called particle size, Rh) and distribution of particle size were measured by a dynamic light scattering technique. The radiation yield of intermolecular crosslinking of CMS solution was calculated from the expression of Gx (Charlesby, 1960; Jung-Chul, 2010). The influence of the "size effect" was demonstrated by testing culture of Lactobacillus bacteria on MRS agar culture medium containing CMS nanogel and polymer. Results showed that the number of Lactobacillus bacteria growing on nanogel containing culture medium is about 170 cfu/ml and on polymer containing culture medium is only 6 cfu/ml.

  4. Influence of radiation temperature on the crosslinking of nitrile rubber by electron beam irradiation

    International Nuclear Information System (INIS)

    Nitrile rubber with 18% acrylonitrile content in presence and absence of polyfunctional monomers like trimethylolpropane triacrylate (TMPTA), tripropyleneglycol diacrylate (TPGDA), tetramethylolmethane tetraacrylate (TMMT) and m-phenylene bismaleimide was subjected to electron beam irradiations at different temperatures. The structural changes with different doses of radiations were investigated with the help of FTIR spectroscopy (in the ATR mode), dynamic mechanical thermal analysis and sol-gel analysis. There was a decrease in the concentration of olefinic groups for this elastomer on radiation at high temperature as compared to the room temperature. The increase in crosslinking at elevated temperature was also revealed by the increase in % gel content and dynamic storage moduli with radiation dose. The lifetime of spurs, an important criterion for overlapping of spurs, was determined for both grafted and ungrafted nitrile rubber using a mathematical model. The ratio of scissioning to crosslinking for nitrile rubber was determined using Charlesby-Pinner equation. The mechanical properties were studied and the tensile strength was found to increase with grafting of polyfunctional monomers on irradiation at high temperature

  5. Comparison of γ-radiation and electron beam irradiation effects on gelatin

    International Nuclear Information System (INIS)

    Gelatin is a heterogeneous mixture of water-soluble proteins of high average molecular weight derived by hydrolytic action from collagen, a protein of mammal external protective tissues. There are many characteristics of a material that can indicate its quality or performance in its intended use. The knowledge of a material's rheological characteristics is valuable to predict its pourability, its performance in a dipping or coating operation or the ease with which it may be handled, processed or used. In this work bovine powder gelatin was submitted to γ-radiation from a 60Co source, dose rate about 7 kGy/h and to electron beam irradiation, dose rate about 11 kGy/s. The doses applied were 5, 10, 20 and 50 kGy. The radiation effects were measured following viscosity changes at 40 deg. C of gelatin powder 10% aqueous solutions. The relationship between the decrease in viscosity of gelatin solutions and radiation dose presented close comparable values for both irradiation processes

  6. Disinfection and reduction of organic load of sewage water by electron beam radiation

    Science.gov (United States)

    Maruthi, Y. Avasn; Das, N. Lakshmana; Hossain, Kaizar; Sarma, K. S. S.; Rawat, K. P.; Sabharwal, S.

    2011-09-01

    The efficacy of electron beam radiation for the disinfection and reduction of organic load of sewage water was assessed with ILU-6 Accelerator at Radiation Technology Development Division of the Bhabha Atomic Research Centre, Mumbai India. The current problem on environmental health in relation to water pollution insists for the safe disposal of sewage water. In general, sewage water comprises heterogeneous organic based chemicals as well as pathogens. EB treatment of the wastewater has found to be very effective in reducing the pathogens as well as organic load. EB dose of 1.5 kGy was sufficient for complete elimination of total coli forms. The experimental results elucidated the reduction of biological oxygen demand—BOD (35 and 51.7%) in both inlet and outlet sewage samples. Similarly reduction of chemical oxygen demand—COD was observed (37.54 and 52.32%) in both sewage samples with respect to increase in irradiation doses (0.45-6 kGy). The present study demonstrated the potential of ionizing radiation for disinfection of sewage and to increase the water quality of the wastewater by decreasing BOD and COD. So, the irradiation sewage water can find its application either in agriculture for irrigation, in industry for cooling purpose and some selected domestic purposes.

  7. Effect of radiation by electron beam on the mechanical properties of high density polyethylene

    International Nuclear Information System (INIS)

    In this work, the high density polyethylene (HDPE) was submitted to radiation doses ranging from 150 to 250 kGy in a 1.5 MeV electron accelerator, with purpose to evaluate the radiation dose effects on his mechanical properties. The irradiations were accomplished at 14 kGy/s dose, room temperature and presence of air. The material mechanical properties changes due to the irradiation were evaluated by means of traction and flexure resistance tests. The results presented a gain up to 150 % in the original rupture traction of the HDPE (not irradiated samples, gain up to 10 % in the percentage of maximum elongation in rupture for the irradiated samples, except for the 250 kGy, where no significant changes were observed (p < 0.05). The results also presented gains up to 20 % in the flexure resistance and losses of the order of 3 to 4 % in the traction resistance in the HDPE drainage related to the original, for the studied radiation dose interval (p <0.05). These results indicate that the irradiation by electron beam, at the conditions studied in this work, is a adequate d process for the modification of the HDPE mechanical properties, mainly for those applications requiring a high resistance to the traction solicitations

  8. A novel diamond-based beam position monitoring system for the High Radiation to Materials facility at CERN SPS

    CERN Document Server

    AUTHOR|(CDS)2092886; Höglund, Carina

    The High Radiation to Materials facility employs a high intensity pulsed beam imposing several challenges on the beam position monitors. Diamond has been shown to be a resilient material with its radiation hardness and mechanical strength, while it is also simple due to its wide bandgap removing the need for doping. A new type of diamond based beam position monitor has been constructed, which includes a hole in the center of the diamond where the majority of the beam is intended to pass through. This increases the longevity of the detectors as well as allowing them to be used for high intensity beams. The purpose of this thesis is to evaluate the performance of the detectors in the High Radiation to Materials facility for various beam parameters, involving differences in position, size, bunch intensity and bunch number. A prestudy consisting of calibration of the detectors using single incident particles is also presented. The detectors are shown to work as intended after a recalibration of the algorithm, alb...

  9. Construction and performance test of radiation shielding for 300 keV/20 mA electron beam machine

    International Nuclear Information System (INIS)

    The construction and performance test of radiation shielding for 300 keV/20 mA electron beam machine (EBM) has been done. Radiation shielding is used for reduce X-ray radiation which is generated by operation of the EBM, so it is not harmful for people who work in that environment. Radiation shielding plates made of bars of lead (Pb) with a length of 135 cm, 10 cm of width, 2.5 cm of thick and composed a EBM radiation shielding. The plates are made of lead by way of casting and finished mechanically by machine, then installed manually on a frame to form a EBM radiation shielding. In the calculation of thick radiation shield already qualified dose rate limit is set by BAPETEN ≤ 2.5 mrem/hr. The results of the initial test radiation shielding is functioning, it is shown by the results of measurements of the maximum dose rate 0.26 mrem/hr at the operating conditions of EBM with voltage 209 kV and 50 mA of electron beam current. Based on the results test of the construction of radiation shielding are qualified dose rate limit set by BAPETEN. (author)

  10. Optical modulation of electron beam using the opto-semiconductor device on the photocathode RF gun for the radiation therapy

    International Nuclear Information System (INIS)

    The radiation therapy of cancer is developing to un-uniform irradiation, for concentrating dose to a tumor and reducing dose to normal tissue. For the un-uniform irradiation, optical modulation of electron beam using the Digital Micro Mirror Device was studied on a photocathode RF gun. The optical modulation of electron beam and dynamic control succeeded by a digital micro mirror device. Fundamental data such as the spatial resolution and the contrast of the optical modulated electron beam was measured. It will be reported that the relations between the intensity distribution and the emittance. (author)

  11. Time resolved energy measurement of the Tesla test facility beam through the analysis of optical transition radiation angular distribution

    International Nuclear Information System (INIS)

    This study of the energy stability along the macropulse of the Tesla test facility Linac (TTFL) (1) was obtained by the measurement of the angular distribution of the optical transition radiation (OTR). This technique does not require a dispersive section and can be performed at any point of the beam line. Measurements have been performed with different settings of the RF low level control and at different values of the beam current. An energy variation along the macropulse was spread of the whole macrobunch. The analysis of the OTR angular distribution pattern allows also, to some extent, to evaluate the beam angular spread

  12. On the generation of supershort avalanche electron beams and x radiation during nanosecond discharges in dense gases (results and discussion)

    Science.gov (United States)

    Tarasenko, V. F.; Rybka, D. B.; Baksht, E. H.; Kostyrya, I. D.; Lomaev, M. I.

    2007-09-01

    Results of investigations of the generation of subnanosecond runaway electron beams and x radiation in gas diodes at elevated pressures are presented. The energy distributions of runaway electron beams generated in air at atmospheric pressure and the amplitude and duration of beam current pulses downstream of the foil have been measured, and also the mechanism of generation of a runaway electron beam has been analyzed. To record the beam current pulses, a collector which provided ˜50-ps time resolution and a Tektronix TDS6604 real-time oscilloscope were used in the experiment. It has been shown that the new experimental data and model predictions confirm in the main the results earlier obtained at the Institute of High Current Electronics of the Russian Academy of Sciences Siberian Division. Evidence is cited that the key statements of L. P. Babich are erroneous.

  13. Quality control methodology and implementation of X-radiation standards beams, mammography level, following the standard IEC 61267

    International Nuclear Information System (INIS)

    In this work it was developed and applied a quality control program of the X radiation system (160 kV, constant potential, target of tungsten) of the Calibration Laboratory of IPEN(LCI) in the energy range relative to mammography beams (from 25 kV to 35 kV). The X radiation standards beams, level mammography, using molybdenum and aluminum as additional filtration, were established after the application of this quality control program following national and international recommendations. The reference ionization chamber has traceability to PTB and was regularly submitted to quality control tests for evaluation and analysis of its performance. The radiation qualities emerging from the X-radiation assembly (RQR-M), based on a phantom made up of an aluminum added filter (RQA-M), narrow beam condition (RQN-M) and broad beam condition (RQB-M), following the recommendations of the international standard IEC 61267 (2005) and the IAEA code of practice, TRS 457 (2007) were established. For the implantation of RQN-M and RQB-M radiation qualities, two mammography phantoms were developed. The half-value layers found are those presented by the German primary laboratory PTB, and varied from 0.35 to 1.21 mm Al. The air kerma rates were obtained for all the 15 implanted qualities. (author)

  14. Adaptive Radiation Therapy for Postprostatectomy Patients Using Real-Time Electromagnetic Target Motion Tracking During External Beam Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: Using real-time electromagnetic (EM) transponder tracking data recorded by the Calypso 4D Localization System, we report inter- and intrafractional target motion of the prostate bed, describe a strategy to evaluate treatment adequacy in postprostatectomy patients receiving intensity modulated radiation therapy (IMRT), and propose an adaptive workflow. Methods and Materials: Tracking data recorded by Calypso EM transponders was analyzed for postprostatectomy patients that underwent step-and-shoot IMRT. Rigid target motion parameters during beam delivery were calculated from recorded transponder positions in 16 patients with rigid transponder geometry. The delivered doses to the clinical target volume (CTV) were estimated from the planned dose matrix and the target motion for the first 3, 5, 10, and all fractions. Treatment adequacy was determined by comparing the delivered minimum dose (Dmin) with the planned Dmin to the CTV. Treatments were considered adequate if the delivered CTV Dmin is at least 95% of the planned CTV Dmin. Results: Translational target motion was minimal for all 16 patients (mean: 0.02 cm; range: −0.12 cm to 0.07 cm). Rotational motion was patient-specific, and maximum pitch, yaw, and roll were 12.2, 4.1, and 10.5°, respectively. We observed inadequate treatments in 5 patients. In these treatments, we observed greater target rotations along with large distances between the CTV centroid and transponder centroid. The treatment adequacy from the initial 10 fractions successfully predicted the overall adequacy in 4 of 5 inadequate treatments and 10 of 11 adequate treatments. Conclusion: Target rotational motion could cause underdosage to partial volume of the postprostatectomy targets. Our adaptive treatment strategy is applicable to post-prostatectomy patients receiving IMRT to evaluate and improve radiation therapy delivery

  15. Optimal beam design on intensity-modulated radiation therapy with simultaneous integrated boost in nasopharyngeal cancer

    International Nuclear Information System (INIS)

    This study aims to determine the optimal beam design among various combinations of field numbers and beam trajectories for intensity-modulated radiation therapy (IMRT) with simultaneous integrated boost (SIB) technique for the treatment of nasopharyngeal cancer (NPC). We used 10 fields with gantry angles of 155°, 130°, 75°, 25°, 0° L, 0° R, 335°, 285°, 230°, and 205° denoted as F10. To decrease doses in the spinal cord, the F10 technique was designed by featuring 2 pairs of split-opposed beam fields at 155° to 335° and 205° to 25°, as well as one pair of manually split beam fields at 0°. The F10 technique was compared with 4 other common field arrangements: F7E, 7 fields with 50° equally spaced gantry angles; F7, the basis of F10 with 155°, 130°, 75°, 0°, 285°, 230°, and 205°; F9E, 9 fields with 40° equally spaced gantry angles; and FP, 7 posterior fields with 180°, 150°, 120°, 90°, 270°, 240°, and 210°. For each individual case of 10 patients, the customized constraints derived after optimization with the standard F10 technique were applied to 4 other field arrangements. The 4 new optimized plans of each individual case were normalized to achieve the same coverage of planning target volume (PTV)63 Gy as that of the standard F10 technique. The F10 field arrangement exhibited the best coverage in PTV70 Gy and the least mean dose in the trachea-esophagus region. Furthermore, the F10 field arrangement demonstrated the highest level of conformity in the low-dose region and the least monitor unit. The F10 field arrangement performed more outstandingly than the other field arrangements in PTV70 Gy coverage and spared the central organ. This arrangement also exhibited the highest conformity and delivery efficiency. The F10 technique is recommended as the standard beam geometry for the SIB-IMRT of NPC

  16. Increasing Use of Dose-Escalated External Beam Radiation Therapy for Men With Nonmetastatic Prostate Cancer

    International Nuclear Information System (INIS)

    Purpose: To examine recent practice patterns, using a large national cancer registry, to understand the extent to which dose-escalated external beam radiation therapy (EBRT) has been incorporated into routine clinical practice for men with prostate cancer. Methods and Materials: We conducted a retrospective observational cohort study using the National Cancer Data Base, a nationwide oncology outcomes database in the United States. We identified 98,755 men diagnosed with nonmetastatic prostate cancer between 2006 and 2011 who received definitive EBRT and classified patients into National Comprehensive Cancer Network (NCCN) risk groups. We defined dose-escalated EBRT as total prescribed dose of ≥75.6 Gy. Using multivariable logistic regression, we examined the association of patient, clinical, and demographic characteristics with the use of dose-escalated EBRT. Results: Overall, 81.6% of men received dose-escalated EBRT during the study period. The use of dose-escalated EBRT did not vary substantially by NCCN risk group. Use of dose-escalated EBRT increased from 70.7% of patients receiving treatment in 2006 to 89.8% of patients receiving treatment in 2011. On multivariable analysis, year of diagnosis and use of intensity modulated radiation therapy were significantly associated with receipt of dose-escalated EBRT. Conclusions: Our study results indicate that dose-escalated EBRT has been widely adopted by radiation oncologists treating prostate cancer in the United States. The proportion of patients receiving dose-escalated EBRT increased nearly 20% between 2006 and 2011. We observed high utilization rates of dose-escalated EBRT within all disease risk groups. Adoption of intensity modulated radiation therapy was strongly associated with use of dose-escalated treatment

  17. High flux and high resolution VUV beam line for synchrotron radiation

    International Nuclear Information System (INIS)

    A beam line has been optimized for high flux and high resolution in the wavelength range from 30 nm to 300 nm. Sample chambers for luminescence spectroscopy on gaseous, liquid and solid samples and for photoelectron spectroscopy have been integrated. The synchrotron radiation from the storage ring DORIS (at DESY, Hamburg) emitted into 50 mrad in horizontal and into 2.2 mrad in vertical direction is focused by a cylindrical and a plane elliptical mirror into the entrance slit of a 2m normal incidence monochromator. The light flux from the exit slit is focused by a rotational elliptic mirror onto the sample yielding a size of the light spot of 4 x 0.15 mm2. The light flux at the sample reaches 7 x 1012 photons nm-1s-1 at 8 eV photon energy for a current of 100 mA in DORIS. A resolution of 0.007 nm has been obtained. (orig.)

  18. Retina Pathology of a Failed External Beam-Radiated Group Vb Retinoblastoma

    Directory of Open Access Journals (Sweden)

    Hsin-Yuan Tan

    2002-08-01

    Full Text Available We report on a 7-month-old boy who suffered from retinoblastoma with presentation ofa white pupillary reflex in his right eye. Initial examination showed a large subretinal andintraretinal mass nasally with extensive vitreous seeding of tumor cells (Group Vb in theReese-Ellsworth classification. External beam radiation therapy (EBRT was applied inhopes of preserving the eye, and significant regression with disappearance of vitreous seedingsand a prominently decreased tumor mass with localized calcification were documented.Unfortunately total retinal detachment was subsequently identified 3 months after irradiation.The patient ultimately underwent enucleation, and histopathology revealed significantcalcification within the residual tumor without marked necrosis; a preretinal fibrous membranewith focal vascular thickening was noted, which implied a partial but incompleteeffect of EBRT for this group Vb retinoblastoma. We describe the histopathological findingsof the failure of irradiation for a group Vb retinoblastoma, and emphasize the importance ofearly application of EBRT treatment for a retinoblastoma.

  19. Development of photon beam diagnostics for VUV radiation from a SASE FEL

    CERN Document Server

    Treusch, R; Xu, W; Jastrow, U; Hahn, U; Bittner, L; Feldhaus, J

    2000-01-01

    For the proof-of-principle experiment of self-amplified spontaneous emission (SASE) at short wavelengths on the VUV FEL at DESY a multi-facetted photon beam diagnostics experiment has been developed employing new detection concepts to measure all SASE specific properties on a single pulse basis. The present setup includes instrumentation for the measurement of the energy and the angular and spectral distribution of individual photon pulses. Different types of photon detectors such as PtSi-photodiodes and fast thermoelectric detectors based on YBaCuO-films are used to cover some five orders of magnitude of intensity from the level of spontaneous emission to FEL radiation at saturation. A 1 m normal incidence monochromator in combination with a fast intensified CCD camera allows to select single photon pulses and to record the full spectrum at high resolution to resolve the fine structure due to the start-up from noise.

  20. Radiation vulcanization of natural rubber latex with 3 MeV electron beams, 1

    International Nuclear Information System (INIS)

    The sensitized radiation vulcanization of natural rubber latex has been carried out with a 3 MeV, 25 mA Dynamitron electron accelerator. Latex was irradiated over a range of dose rate from 0.3 to 60 kGy/sec in the presence of sensitizers such as n-butyl acrylate, 2-ethylhexyl acrylate, and 1,6-hexanediol diacrylate. The sensitized vulcanization of NR latex with electron beams is greatly affected by dose rate. The vulcanization dose increases with increasing dose rate. The maximum tensile strength of rubber films from the irradiated latex decreases slightly with increasing dose rate. There is negligible effect of dose rate on the viscosity of the irradiated latex. (author)

  1. Radiation chemical investigations of Fricke solution using 30 MeV alpha beam from cyclotron

    International Nuclear Information System (INIS)

    Systematic investigations on the radiolysis of liquid systems using 30 MeV alpha beam from cyclotron at the Variable Energy Cyclotron Centre (VECC) have been initiated. A liquid target assembly incorporating current measurement devices in solution as well as on the target assembly window has been designed. Suitable aluminium absorbers of different thickness have been used to extract different energies of alpha ranging from 24.82 MeV to 6.41 MeV corresponding to the LET range of 2.77 eV/A0 to 7.98 eV/A0. A fricke solution using 10 mM Fe2+ in 0.8 NH2SO4 in presence of 5mM NaCl under continuous oxygen bubbling has been radiolysed with radiation of different LET. The effect of LET on the G(Fe3+) has been investigated and the results are discussed. (author)

  2. The effect of a metal hip prosthesis on the radiation dose in therapeutic photon beam irradiations

    International Nuclear Information System (INIS)

    Prostate and cervical cancer patients are often treated with external X-ray beams of bi-lateral incidence. Such treatment may incur some dose effect that cannot be predicted precisely in commercial treatment planning systems (TPS) for patients having undergone total hip replacement. This study performs a Monte Carlo (MC) simulation and an analytical calculation (convolution superposition algorithm which is implemented in ADAC TPS) of a 6 MV, 5x5 cm2 X-ray beam incident into water with the existence of hip prosthesis, e.g. Ti6Al4V and CoCrMo alloy. The results indicate that ADAC TPS cannot precisely account for the scatter and backscatter radiation that a metal hip prosthesis causes. For percent depth dose (PDD) curves, the maximum underdosage of ADAC TPS up to 5 mm above the interface between dense material and water is 5%, 20% and 27% for PDDBone, PDDTi and PDDCo, respectively. The dose re-buildup, which occurs behind the hip region, becomes more and more obvious for denser medium existed in water. Increasing inhomogeneity also enhances the underdosage of ADAC for greater depth (>10 cm), as the figures of nearly 2% in PDDBone, PDDTi and 4-5% in PDDCo reveal. Overestimating the attenuated power of high-density non-water material in ADAC TPS causes this underdosage. For dose profiles, no significant differences were found in ProfileBone at any depth. ProfileTi reveals that MC slightly exceeds ADAC at off-axis position 1.0-2.0 cm. ProfileCo reveals this more obviously. This finding means that scatter radiation from these denser materials is significant and cannot be predicted precisely in ADAC

  3. Radiation Dose From Kilovoltage Cone Beam Computed Tomography in an Image-Guided Radiotherapy Procedure

    International Nuclear Information System (INIS)

    Purpose: Image-guided radiation therapy has emerged as the new paradigm in radiotherapy. This work is to provide detailed information concerning the additional imaging doses to patients' radiosensitive organs from a kilovoltage cone beam computed tomography (kV CBCT) scan procedure. Methods and Materials: The Vanderbilt-Monte-Carlo-Beam-Calibration (VMCBC; Vanderbilt University, Nashville, TN) algorithm was used to calculate radiation dose to organs resulting from a kV CBCT imaging guidance procedure. Eight patients, including 3 pediatric and 5 adult patients, were investigated. The CBCT scans in both full- and half-fan modes were studied. Results: For a head-and-neck scan in half-fan mode, dose-volume histogram analyses show mean doses of 7 and 8 cGy to the eyes, 5 and 6 cGy to the spinal cord, 5 and 6 cGy to the brain, and 18 and 23 cGy to the cervical vertebrae for an adult and a 29-month-old child, respectively. The dose from a scan in full-fan mode is 10-20% lower than that in half-fan mode. For an abdominal scan, mean doses are 3 and 7 cGy to prostate and 7 and 17 cGy to femoral heads for a large adult patient and a 31-month-old pediatric patient, respectively. Conclusions: Doses to radiosensitive organs can total 300 cGy accrued over an entire treatment course if kV CBCT scans are acquired daily. These findings provide needed data for clinicians to make informed decisions concerning additional imaging doses. The dose to bone is two to four times greater than dose to soft tissue for kV x-rays, which should be considered, especially for pediatric patients

  4. Hypofractionated electron-beam radiation therapy for keloids. Retrospective study of 568 cases with 834 lesions

    International Nuclear Information System (INIS)

    We aimed to analyze the outcomes of hypofractionated high-energy electron beam radiotherapy for the treatment of keloids. From February 1998 to January 2012, 568 patients with a total of 834 keloids underwent radiotherapy: 826 lesions with postoperative radiotherapy, and 36 with skin-grafting. Lesion size was >5 cm in 335 keloids. An electron-beam of 6 or 7 MeV was used, with a total dose of 18 Gy (two fractions with a 1-week interval) covering the lesion with a 1-cm margin. The time between surgery and radiotherapy was 24–48 h. Skin-grafted patients underwent radiotherapy 10–15 days after the operation. The median follow-up was 40 months (range: 12–160 months). The local control rate was 88.25% (736/834). The relapse rate was 9.59% (80/834), and the time to relapse was 6–28 months (median: 12 months). Univariate analyses showed that gender, age, keloid size, keloid site, skin grafting, and operation-to-irradiation interval influenced the local control rate. Multivariate analysis showed that the relapse rate was correlated with gender (P = 0.048), age (P < 0.01), operation-to-irradiation interval (P < 0.01), keloid site (P < 0.01), surgical method (P = 0.04) and keloid size (P < 0.02). Adverse effects were observed in 9.83% (82/834). No radiation-induced cancers were observed. Hypofractionated high-energy electron beam radiotherapy for keloids yielded excellent outcomes, especially in cases without skin grafting. Early postoperative radiotherapy with limited hypofractionation could be a good choice for keloid treatment. (author)

  5. Optical tomographic in-air scanner for external radiation beam 3D gel dosimetry

    International Nuclear Information System (INIS)

    Full text: Optical CT scanners are used to measure 3D radiation dose distributions in radiosensitive gels. For radiotherapy dose verification, 3D dose measurements are useful for verification of complex linear accelerator treatment planning and delivery techniques. Presently optical CTs require the use of a liquid bath to match the refractive index of the gel to minimise refraction of the light rays leading to distortion and artifacts. This work aims to develop a technique for scanning gel samples in free-air, without the requirement for a matching liquid bath. The scanner uses a He-Ne laser beam, fanned across the acrylic cylindrical gel container by a rotating mirror. The gel container was designed to produce parallel light ray paths through the gel. A pin phantom was used to quantify geometrical distortion of the reconstructed image, while uniform field exposures were used to consider noise, uniformity and artifacts. Small diameter wires provided an indication of the spatial resolution of the scanner. Pin phantom scans show geometrical distortion comparable to scanners using matching fluid baths. Noise, uniformity and artifacts were not found to be major limitations for this scanner approach. Spatial resolution was limited by laser beam spot size, typically 0.4 mm full width half maximum. A free-air optical CT scanner has been developed with the advantage of scanning without a matching fluid bath. Test results show it has potential to provide suitable quality 3D dosimetry measurements for external beam dose verification, while offering significant advantages in convenience and efficiency for routine use.

  6. Improvement of the fracture toughness matrix cured by electron beam radiation, by incorporation of thermoplastic

    International Nuclear Information System (INIS)

    The aim of the present study is to improve the fracture toughness of a vinyl-ester matrix cured by electron beam radiation, by incorporation of a thermoplastic polymer. The ultimate plan is to improve the fracture toughness of the composite material made of this reinforced matrix and carbon fibres. The first step deals with the study of an epoxy matrix reinforced by a polyether-sulfone. This well-known material, as it is used in industrial formulation, allowed us to characterize all the parameters needed to obtain a good reinforcement as for instance the morphology, and also to compare two kinds of processes: thermal and electron beam curing. In fact, we are really interested in increasing fracture toughness of a vinyl-ester matrix that is not miscible with polyether-sulfone. So a copolymer which has a similar structure as polyether-sulfone is synthesized in order to obtain a miscible blend. The corresponding material has good fracture toughness, with an increase of 80 % for 15 % addition of thermoplastic. (author)

  7. Investigation on metal corrosion phenomena by using synchrotron radiation and neutron beams

    International Nuclear Information System (INIS)

    Synchrotron radiation beam, which can be used as diffraction, X-ray absorption fine structure, imaging, photoelectron spectroscopy, etc., has an advantage of ultra-bright, highly-directional, and so forth in comparison with conventional X-ray equipment. Therefore, its application has been expanded to various metal corrosion phenomena such as atmospheric corrosion of steels, the influence of alloying elements on the formation and structure of rusts of weathering steels, the underpotential deposition behavior of Pb on Ni electrode, the non-destructive in-depth analysis of the passive film of stainless steel, etc. In contrast, neutron beam, which can be used as neutron diffraction, small angle neutron scattering, neutron imaging, etc., has unique properties such as high transmittance and high sensitivity to hydrogen and water. From these features, it has been applied to metal corrosion researches such as the change of average size and volume fraction of weathering steel rusts during wet/dry cycles, the direct observation of water motion under blister of under-film corroded steels, etc. (author)

  8. Radiation synthesis of chitosan stabilized gold nanoparticles comparison between e− beam and γ irradiation

    International Nuclear Information System (INIS)

    Gold nanoparticles were synthesized via radiolytic reduction of Au(III) salts induced by e− beam or γ-irradiation, using chitosan as a stabilizer. The effect of irradiation dose, chitosan concentration and the conditioning of HAuCl4–chitosan solutions were studied. UV–visible absorption measurements reveal that the size of Au clusters formed immediately after irradiation is correlated with the extent of chitosan scission chain of chitosan and fall with the increase of dose absorbed. This effect is more pronounced with solution conditioned under Argon (Ar). Au clusters coalesce to form stable nanoparticles after two weeks. - Highlights: • This paper underlines the potential of ionizing radiations in the synthesis of AuNps. • The size of the nanoparticles, and their stability are controlled by the ratio [GLA]/[Au(III)] • This paper compares results obtained with e− beam and γ irradiation for the AuNps synthesis. • This paper points the influence of dose rate on the size of preformed Au clusters

  9. Radiative transport produced by oblique illumination of turbid media with collimated beams

    Science.gov (United States)

    Gardner, Adam R.; Kim, Arnold D.; Venugopalan, Vasan

    2013-06-01

    We examine the general problem of light transport initiated by oblique illumination of a turbid medium with a collimated beam. This situation has direct relevance to the analysis of cloudy atmospheres, terrestrial surfaces, soft condensed matter, and biological tissues. We introduce a solution approach to the equation of radiative transfer that governs this problem, and develop a comprehensive spherical harmonics expansion method utilizing Fourier decomposition (SHEFN). The SHEFN approach enables the solution of problems lacking azimuthal symmetry and provides both the spatial and directional dependence of the radiance. We also introduce the method of sequential-order smoothing that enables the calculation of accurate solutions from the results of two sequential low-order approximations. We apply the SHEFN approach to determine the spatial and angular dependence of both internal and boundary radiances from strongly and weakly scattering turbid media. These solutions are validated using more costly Monte Carlo simulations and reveal important insights regarding the evolution of the radiant field generated by oblique collimated beams spanning ballistic and diffusely scattering regimes.

  10. Study of the behavior of radiation detectors for mammography in standard beams using a clinical system

    International Nuclear Information System (INIS)

    A mammogram is the x-ray of the breast that allows early detection of cancer, by being able to show lesions in very small early stage. But to get an early and reliable diagnosis is necessary that the mammography unit is calibrated and working properly, otherwise there may be a loss in image produced, may lead to a false diagnosis, and possible harm to the patient. So it is important to control these devices, especially in relation to the radiation produced by them. In this project, we propose a study of the behavior of ionization chambers for mammography calibrated beam patterns in a clinical system (Philips-VMI mammography, Graph Mammo AF, which operates a range of 20 to 35 kV) from Instruments Calibration Laboratory at IPEN-CNEN/SP, with the aim of determining parameters correction approaching conditions calibration conditions for clinical use. Measurements of the parameters of the beams set in mammography using simulators acrylic specially developed for these measurements were performed in order to establish a new protocol for calibration of the ionization chambers in a clinical system rather than the industrial system, or as a complement to this. (author)

  11. Dose Rate Effects on The Radiation Oxidation of Polyethylene: Electron Beam vs Gamma Irradiation

    International Nuclear Information System (INIS)

    The yields and spatial distribution of the oxidation products stemming from the oxidation of LLPE films induced by 60-Co gamma and by irradiation with 300 kev, 0.3 mA electrons in the dose range 0.04 kGy/h - 0.6 kGy/h (gamma) and at 1.5 kGy/hr ( e-beam) have been determined by applying a methodology involving FTIR microscopy (carbonyl products, resolution 10 μ), iodometric analysis (peroxides). The FTIR and EPR spectroscopies coupled with the multilayer technique (resolution 25 μ) were also employed for carrying on measurements of the film depth profiles of peroxyl radicals and their alky radicals precursors, radical decay kinetics, 'free' and ' bound' hydroperoxides and alcools. With gamma radiations the products yields are enhanced following the decrease of the dose rate from 0.7 to 0.04 kGy/h without substantial effect on the film depth distributions which appear rather uniform. Using e-beam (dose rate 1.5 kGy/h) a low level concentration limit is attained confined within the first 50 μ which is about 1 order of magnitude smaller as compared to gamma. The mechanistic implications inherent to the experimental results as well as the practical consequences related to the use of radiooxidation as a tool for inducing graft copolymerization reactions are discussed

  12. Brain tumors and synchrotron radiation: new methods for mini-beams radiation therapy and treatment follow-up by functional imaging

    International Nuclear Information System (INIS)

    An innovative method of synchrotron radiation therapy, called mini-beams, was proposed by A. Dilmanian et al. in 2006. Mini-beams consists in tumor irradiation with monochromatic sub-millimetric x-ray beams spatially fractionated produced by a synchrotron source. To obtain a homogeneous dose in the target volume, an interleaving is realized using two orthogonal incidences. Adjacent healthy tissue is only partially irradiated by mini-beams, the areas between the beams only receive scattered radiation and therefore the energy deposited is 10 to 15 times lower than on one mini-beam axis, leading to a sparing effect of healthy tissue even when a high dose is deposited in the target volume. The thesis project is the development of this experimental method of monochromatic mini-beams, which involves the control of the irradiation geometry, the control of dosimetry and its modeling by Monte Carlo simulations. To evaluate the method, preclinical experiments on models of brain tumors implanted in rats (F98) are performed. Follow-up by anatomical and functional imaging is carried out to evaluate the effectiveness of the treatment. Functional imaging of cerebral perfusion (volume and cerebral blood flow, mean transit time of heavy elements) appears to be associated in the literature as a relevant method for monitoring prognostic. The key parameters of the cerebral vasculature are mainly studied in magnetic resonance imaging (MRI), because of the harmlessness of this imaging modality. The relation between MRI signal and contrast agent concentration is very complex and no quantitative relationship is well known. Synchrotron Radiation Computed Tomography (SRCT) is an imaging modality with performances to measure absolute contrast agent concentration very close to the theoretical limits and can be used as gold-standard. The used pharmacokinetic models need as input parameters a contrast agent concentration versus time. A comparison of perfusion measurements between MRI and SRCT

  13. The WebCam vs. the Particle Beam: A CRaTER Visualization of the Effects of Radiation

    Science.gov (United States)

    Case, A. W.; Gross, N. A.; Spence, H. E.

    2008-12-01

    The term "radiation" can cause significant anxiety to a general audience in part because of the associated health risks, but also because of lack of a conceptual framework about the nature of radiation. A visual depiction of radiation may go a long way towards providing just such a framework. The CRaTER Team had an opportunity to create just such a video. The Cosmic Ray Telescope for the Effects of Radiation (CRaTER) is a radiation instrument that will fly on the Lunar Reconnaissance Orbiter (LRO) and is designed to determine the effects of energetic particles on living tissue. In order to calibrate CRaTER and characterize its reaction to various radiation environments, the CRaTER team has used particle beam facilities include the Proton Radiation Therapy Facility at Massachusetts General Hospital (MGH). During one of the sessions at MGH, the team placed an off the shelf web camera into the beam and recorded the visual effects. This video recording was used as the basis for an edited video describing what was done and the results. The hope is that this video will provide a general audience with a visual framework for the nature and effects of radiation

  14. Incidence of primary hypothyroidism in patients exposed to therapeutic external beam radiation, where radiation portals include a part or whole of the thyroid gland

    Directory of Open Access Journals (Sweden)

    B A Laway

    2012-01-01

    Full Text Available Introduction: Hypothyroidism is a known consequence of external-beam radiotherapy to the neck encompassing a part or whole of the thyroid gland. In this non-randomized prospective study, we have tried to evaluate the response of the thyroid gland to radiation by assessing thyroid function before irradiation and at regular intervals after irradiation. Aims and Objectives: The aim of this study were to assess in the cancer patients, who were exposed to the therapeutic external beam radiation, where radiation portals include a part or whole of the thyroid gland: the incidence of primary hypothyroidism, the time required to become hypothyroid, any relation between the total dose for the development of hypothyroidism, and whether there are any patient or treatment-related factors that are predictive for the development of hypothyroidism, including the use of concurrent chemotherapy. Materials and Methods: This non-randomized, prospective study was conducted for a period of 2 years in which thyroid function was assessed in 59 patients (cases of head and neck cancer, breast cancer, lymphoma patients and other malignancies, who had received radiotherapy to the neck region. 59 euthyroid healthy patients (controls were also taken, who had not received the neck irradiation. These patients/controls were assessed periodically for 2 years. Results: The incidence of hypothyroidism after external beam radiation therapy (EBRT to neck where radiation portals include part or whole of the thyroid gland was 16.94%, seven cases had subclinical hypothyroidism (11.86% and three cases had clinical hypothyroidism (5.08%. Mean time for development of hypothyroidism was 4.5 months. There was no effect of age, gender, primary tumor site, radiation dose and chemotherapy, whether neoadjuvant or concurrent with the development of hypothyroidism. Conclusion: In summary, we found that thyroid dysfunction is a prevalent, yet easily treatable source of morbidity in patients

  15. Production of pure quasi-monochromatic {sup 11}C beams for accurate radiation therapy and dose delivery verification

    Energy Technology Data Exchange (ETDEWEB)

    Lazzeroni, Marta, E-mail: Marta.Lazzeroni@ki.se; Brahme, Anders

    2015-09-15

    In the present study we develop a new technique for the production of clean quasi-monochromatic {sup 11}C positron emitter beams for accurate radiation therapy and PET–CT dose delivery imaging and treatment verification. The {sup 11}C ion beam is produced by projectile fragmentation using a primary {sup 12}C ion beam. The practical elimination of the energy spread of the secondary {sup 11}C fragments and other beam contaminating fragments is described. Monte Carlo calculation with the SHIELD-HIT10+ code and analytical methods for the transport of the ions in matter are used in the analysis. Production yields, as well as energy, velocity and magnetic rigidity distributions of the fragments generated in a cylindrical target are scored as a function of the depth within 1 cm thick slices for an optimal target consisting of a fixed 20 cm section of liquid hydrogen followed by a variable thickness section of polyethylene. The wide energy and magnetic rigidity spread of the {sup 11}C ion beam can be reduced to values around 1% by using a variable monochromatizing wedge-shaped degrader in the beam line. Finally, magnetic rigidity and particle species selection, as well as discrimination of the particle velocity through a combined Time of Flight and Radio Frequency-driven Velocity filter purify the beam from similar magnetic rigidity contaminating fragments (mainly {sup 7}Be and {sup 3}He fragments). A beam purity of about 99% is expected by the combined method.

  16. Production of pure quasi-monochromatic 11C beams for accurate radiation therapy and dose delivery verification

    International Nuclear Information System (INIS)

    In the present study we develop a new technique for the production of clean quasi-monochromatic 11C positron emitter beams for accurate radiation therapy and PET–CT dose delivery imaging and treatment verification. The 11C ion beam is produced by projectile fragmentation using a primary 12C ion beam. The practical elimination of the energy spread of the secondary 11C fragments and other beam contaminating fragments is described. Monte Carlo calculation with the SHIELD-HIT10+ code and analytical methods for the transport of the ions in matter are used in the analysis. Production yields, as well as energy, velocity and magnetic rigidity distributions of the fragments generated in a cylindrical target are scored as a function of the depth within 1 cm thick slices for an optimal target consisting of a fixed 20 cm section of liquid hydrogen followed by a variable thickness section of polyethylene. The wide energy and magnetic rigidity spread of the 11C ion beam can be reduced to values around 1% by using a variable monochromatizing wedge-shaped degrader in the beam line. Finally, magnetic rigidity and particle species selection, as well as discrimination of the particle velocity through a combined Time of Flight and Radio Frequency-driven Velocity filter purify the beam from similar magnetic rigidity contaminating fragments (mainly 7Be and 3He fragments). A beam purity of about 99% is expected by the combined method

  17. Production of pure quasi-monochromatic 11C beams for accurate radiation therapy and dose delivery verification

    Science.gov (United States)

    Lazzeroni, Marta; Brahme, Anders

    2015-09-01

    In the present study we develop a new technique for the production of clean quasi-monochromatic 11C positron emitter beams for accurate radiation therapy and PET-CT dose delivery imaging and treatment verification. The 11C ion beam is produced by projectile fragmentation using a primary 12C ion beam. The practical elimination of the energy spread of the secondary 11C fragments and other beam contaminating fragments is described. Monte Carlo calculation with the SHIELD-HIT10+ code and analytical methods for the transport of the ions in matter are used in the analysis. Production yields, as well as energy, velocity and magnetic rigidity distributions of the fragments generated in a cylindrical target are scored as a function of the depth within 1 cm thick slices for an optimal target consisting of a fixed 20 cm section of liquid hydrogen followed by a variable thickness section of polyethylene. The wide energy and magnetic rigidity spread of the 11C ion beam can be reduced to values around 1% by using a variable monochromatizing wedge-shaped degrader in the beam line. Finally, magnetic rigidity and particle species selection, as well as discrimination of the particle velocity through a combined Time of Flight and Radio Frequency-driven Velocity filter purify the beam from similar magnetic rigidity contaminating fragments (mainly 7Be and 3He fragments). A beam purity of about 99% is expected by the combined method.

  18. A laser beam welding facility for sealing of miniature radiation sources

    International Nuclear Information System (INIS)

    Full text: A Nd : YAG laser welding facility was installed in a radioactive laboratory of the Radiopharmaceuticals Division, BARC to obtain high quality welds of the titanium encased radiation sources. Radiation sources based on 125I for the treatment of ocular tumors were developed and titanium capsules as specified by IS0 standards were fabricated. The inner core of the tiny sources were prepared and were sealed in titanium capsules of dimensions O.8mm (φ) x 4.5mm (1) by laser welding. The laser beam parameters such as energy, frequency, pulse duration and welding speed were optimized to obtain leak proof welds. Laser welds were also characterized by optical and scanning electron microscopy for assessing its quality. The welded sources showed a total release 125I, which is well below the permissible levels. In this paper we describe the laser welding set up and results of initial development work. We also share our experience to obtain radioactive leak proof laser welding of the 125I sources in titanium capsules

  19. The profile of the electron beam in the PTB synchrotron, and its influence on radiometric measurements with synchrotron radiation

    International Nuclear Information System (INIS)

    A simple method is described to determine the beam profile in an electron synchrotron; the measured results are compared with calculated values. Moreover, the influence of synchrotron- and betatron-oscillations on synchrotron radiation measurements is discussed, and a method is given to correct this. (orig.)

  20. Hounsfield unit recovery in clinical cone beam CT images of the thorax acquired for image guided radiation therapy

    DEFF Research Database (Denmark)

    Slot Thing, Rune; Bernchou, Uffe; Mainegra-Hing, Ernesto;

    2016-01-01

    A comprehensive artefact correction method for clinical cone beam CT (CBCT) images acquired for image guided radiation therapy (IGRT) on a commercial system is presented. The method is demonstrated to reduce artefacts and recover CT-like Hounsfield units (HU) in reconstructed CBCT images of five ...

  1. Bone and mucosal dosimetry in skin radiation therapy: a Monte Carlo study using kilovoltage photon and megavoltage electron beams

    Science.gov (United States)

    Chow, James C. L.; Jiang, Runqing

    2012-06-01

    This study examines variations of bone and mucosal doses with variable soft tissue and bone thicknesses, mimicking the oral or nasal cavity in skin radiation therapy. Monte Carlo simulations (EGSnrc-based codes) using the clinical kilovoltage (kVp) photon and megavoltage (MeV) electron beams, and the pencil-beam algorithm (Pinnacle3 treatment planning system) using the MeV electron beams were performed in dose calculations. Phase-space files for the 105 and 220 kVp beams (Gulmay D3225 x-ray machine), and the 4 and 6 MeV electron beams (Varian 21 EX linear accelerator) with a field size of 5 cm diameter were generated using the BEAMnrc code, and verified using measurements. Inhomogeneous phantoms containing uniform water, bone and air layers were irradiated by the kVp photon and MeV electron beams. Relative depth, bone and mucosal doses were calculated for the uniform water and bone layers which were varied in thickness in the ranges of 0.5-2 cm and 0.2-1 cm. A uniform water layer of bolus with thickness equal to the depth of maximum dose (dmax) of the electron beams (0.7 cm for 4 MeV and 1.5 cm for 6 MeV) was added on top of the phantom to ensure that the maximum dose was at the phantom surface. From our Monte Carlo results, the 4 and 6 MeV electron beams were found to produce insignificant bone and mucosal dose (<1%), when the uniform water layer at the phantom surface was thicker than 1.5 cm. When considering the 0.5 cm thin uniform water and bone layers, the 4 MeV electron beam deposited less bone and mucosal dose than the 6 MeV beam. Moreover, it was found that the 105 kVp beam produced more than twice the dose to bone than the 220 kVp beam when the uniform water thickness at the phantom surface was small (0.5 cm). However, the difference in bone dose enhancement between the 105 and 220 kVp beams became smaller when the thicknesses of the uniform water and bone layers in the phantom increased. Dose in the second bone layer interfacing with air was found to be

  2. Measurement of longitudinal electron beam parameters using indigenously developed streak camera system at Indus-1 synchrotron radiation source

    International Nuclear Information System (INIS)

    Indus-1 is a 450 MeV synchrotron radiation source (SRS) operational at RRCAT, Indore. A diagnostic beamline utilizing visible portion of wide synchrotron radiation spectrum is used for the measurement of electron beam parameters. Its RF frequency and harmonic number are 31.6 MHz and 2 respectively. Among the five operational user beamlines at Indus-1 SRS visible diagnostic beamline (V-DBL, BL-5) is used for the measurement and study of electron beam parameters at dipole magnet DP-3 in Indus-1 .The bunch length represents the extent of longitudinal distribution of electrons inside the bunch, and bunch centroid position is the temporal position or phase of bunch with respect to accelerating voltage inside RF cavity which are important beam dynamics parameters in an accelerator. For measuring the longitudinal beam profile, bunch length, bunch centroid position (of the order of few tens of picoseconds) etc. of the electron beam, a very high temporal resolution device such as streak camera is required to capture the images of the beam in the time domain. For this purpose, an indigenously developed single shot S-20 streak camera has been developed to capture longitudinal profile of electrons bunches in Indus-1 and installed at V-DBL (BL-5). In this paper various measurements carried out using this indigenously developed streak camera system at Indus-1 SRS are discussed

  3. A beaming model of the Io-independent Jovian decameter radiation based on multipole models of the Jovian magnetic field

    International Nuclear Information System (INIS)

    A geometrical model is presented in which the apparent source locations of the Io-independent decameter radiation are computed. The calculations assume that the radiation is produced by stably trapped electrons radiating near the electron gyrofrequency and that the emission is then beamed onto a conical surface. The maximum occurrence probability of noise storms is associated with regions in the Jovian magnetosphere where the axis of the emission cone is most inclined toward the Jovian equatorial plane. The calculations utilize and compare two of the octupole spherical harmonic expansions of the Jovian magnetic field constructed from data accumulated by the fluxgate and vector helium magnetometers on board Pioneer 11

  4. Beaming model of the Io-independent jovian decameter radiation based on multipole models of the jovian magnetic field

    International Nuclear Information System (INIS)

    A geometrical model is presented in which the apparent source locations of the Io-independent decameter radiation are computed. The calculations assume that the radiation is produced by stably trapped electrons radiating near the local electron gyrofrequency and that the emission is then beamed onto a conical surface. The maximum occurrence probability of noise storms is a associated with regions in the Jovian magnetosphere where the axis of the emission cone is most inclined toward the Jovian equatorial plane. The calculations utilize and compare two of the octopole spherical harmonic expansions of the Jovian magnetic field constructed from data accumulated by the fluxgate and vector helium magnetometers on board Pioneer 11

  5. Radioprotective Properties of Allium sativum (Garlic Extract on Cultured Human Lymphocytes against Electron Beam Radiation

    Directory of Open Access Journals (Sweden)

    Shama N Rao

    2015-03-01

    Full Text Available The radioprotective effects of naturally occurring compounds from herbs have been investigated in vitro and in vivo considering their ethnopharmacological role in prevention and treatment of cancer. Allium sativum supplementation in diet has been shown to be beneficial to cancer patients. The present study was designed to detect the radioprotective effect of garlic extract (GE on cultured human peripheral blood lymphocytes. Garlic bulbs were extracted using ethanol and water separately followed by assays on antioxidant activities to assess the efficiency of radical scavenging capacity of various extracts. Lymphocytes were treated with different concentrations of GE for 2, 4, 6 and 24 hr periods. Cell survival was determined by tryphan blue dye exclusion assay, single strand DNA damage by alkaline comet assay and in vitro cytogenetic damages were evaluated by micronucleus assays. Ethanol boiled GE showed highest radical scavenging capacity and reducing property. Treatment of GE to lymphocytes before and after exposure to 4Gy of electron beam radiation (EBR the percentage of tail DNA was reduced from 24.06±3.92 to 2.87±0.18. The elevated micronucleus formation in radiation control group (13.15±0.75 was significantly reduced in various concentrations of GE treated groups (10.35±0.44, 7.05±1.17, 6.42±0.47 respectively. Cells treated with GE at 10µg/mL showed maximum viability after exposure to EBR. Present investigations indicate that ethanol boiled GE shows good radiation protection at 10µg/mL concentration. However, increase in concentration above this dose though resulted in higher protection, increased cell toxicity was also noticed.

  6. Impact of cradle immobilization on setup reproducibility during external beam radiation therapy for lung cancer

    International Nuclear Information System (INIS)

    Purpose: To compare the setup accuracy during fractionated radiation therapy for two patient groups with lung cancer treated with and without an immobilization cradle. Methods: Three hundred ninety-seven port films from 30 patients immobilized in the Alpha CradleTM1 were compared with 329 port films from 30 patients who were not immobilized with the cradle. All patients were treated with curative intent for nonmetastatic lung cancer. The frequency of physician-requested isocenter shifts were compared in the two groups using a two-tailed chi-square test. Initial port films taken on the first day of treatment, routine films taken usually weekly during radiation therapy, and requested films taken after a requested shift were considered separately. The immobilization device consisted of a custom-made foam cradle that extended from above the head to the knees. Patients were generally treated with their arms above their heads, and treatment setup marks in the immobilized patients were placed on both the patients' skin and the immobilization cradle. For the noncradle patients, setup marks were placed only on the patients' skin. Results: For the routine films, the frequency of physician-requested isocenter shifts was lower in immobilized patients than in the nonimmobilized group (p = 0.139). Most of this reduction was seen on oblique fields (p = 0.038). No benefits were seen among initial or requested films. The two groups were well balanced with regard to stage, age, field size, and total dose. Conclusions: The use of aggressive immobilization improves the setup reproducibility in patients receiving external beam radiation therapy for lung cancer, especially during treatment with oblique fields. This improvement in treatment accuracy might improve the therapeutic ratio

  7. Shielding for radiation scattered dose distribution to the outside fields in patients treated with high energy radiotherapy beams

    International Nuclear Information System (INIS)

    Scattered dose of therapeutic high energy radiation beams contributed significant unwanted dose to the patient. Measurement of radiation scattered dose outside fields and critical organs, like fetus position and testicle region, from chest or pelvic irradiation by large field of high energy radiation beam, was performed using an ionization chamber and film dosimetry. The scattered doses outside field were measured 5-10% of maximum doses in fields and exponentially decrease from field margins. The scattered photon dose received the uterus from thorax field irradiation and was measured about 1mGy/Gy of photon treatment dose. Shielding construction to reduce this scattered dose was investigated using lead sheet and blocks About 6 cm lead block shield reduced the scatter photon dose under 10mGy for 60Gy on abdomen field and almost reduced electron contamination. (author)

  8. Design of a distributed radiator target for inertial fusion driven from two sides with heavy ion beams

    International Nuclear Information System (INIS)

    We describe the status of a distributed radiator heavy ion target design. In integrated calculations this target ignited and produced 390-430 MJ of yieldwhen driven with 5.8-6.5 MJ of 3-4 GeV Pb ions. The target has cylindrical symmetry with disk endplates. The ions uniformly illuminate these endplates in a 5mm radius spot. We discuss the considerations which led to this design together with some previously unused design features: low density hohlraum walls in approximate pressure balance with internal low-Z fill materials, radiationsymmetry determined by the position of the radiator materials and particle ranges, and early time pressure symmetry possibly influenced by radiation shims. We discuss how this target scales to lower input energy or to lower beam power. Variant designs with more realistic beam focusing strategies are also discussed. We show the tradeoffs required for targets which accept higher particle energies

  9. Radiation induced currents in parallel plate ionization chambers: Measurement and Monte Carlo simulation for megavoltage photon and electron beams

    International Nuclear Information System (INIS)

    Polarity effects in ionization chambers are caused by a radiation induced current, also known as Compton current, which arises as a charge imbalance due to charge deposition in electrodes of ionization chambers. We used a phantom-embedded extrapolation chamber (PEEC) for measurements of Compton current in megavoltage photon and electron beams. Electron contamination of photon beams and photon contamination of electron beams have a negligible effect on the measured Compton current. To allow for a theoretical understanding of the Compton current produced in the PEEC effect we carried out Monte Carlo calculations with a modified user code, the COMPTON/EGSnrc. The Monte Carlo calculated COMPTON currents agree well with measured data for both photon and electron beams; the calculated polarity correction factors, on the other hand, do not agree with measurement results. The conclusions reached for the PEEC can be extended to parallel-plate ionization chambers in general

  10. Axial and transverse acoustic radiation forces on a fluid sphere placed arbitrarily in Bessel beam standing wave tweezers

    Energy Technology Data Exchange (ETDEWEB)

    Mitri, F.G., E-mail: mitri@chevron.com

    2014-03-15

    The axial and transverse radiation forces on a fluid sphere placed arbitrarily in the acoustical field of Bessel beams of standing waves are evaluated. The three-dimensional components of the time-averaged force are expressed in terms of the beam-shape coefficients of the incident field and the scattering coefficients of the fluid sphere using a partial-wave expansion (PWE) method. Examples are chosen for which the standing wave field is composed of either a zero-order (non-vortex) Bessel beam, or a first-order Bessel vortex beam. It is shown here, that both transverse and axial forces can push or pull the fluid sphere to an equilibrium position depending on the chosen size parameter ka (where k is the wave-number and a the sphere’s radius). The corresponding results are of particular importance in biophysical applications for the design of lab-on-chip devices operating with Bessel beams standing wave tweezers. Moreover, potential investigations in acoustic levitation and related applications in particle rotation in a vortex beam may benefit from the results of this study. -- Highlights: •The axial and transverse forces on a fluid sphere in acoustical Bessel beams tweezers are evaluated. •The attraction or repulsion to an equilibrium position in the standing wave field is examined. •Potential applications are in particle manipulation using standing waves.

  11. Comparison of the Calculated and Measured Dose under Lead Blocks in Radiation Therapy Photon Beams

    International Nuclear Information System (INIS)

    Depth dose data for irregularly shaped fields cannot be previously prepared as they usually are for circular and square fields in photon beams of linacs and Cobalt-60 units. Thus we apply a computer program for that purpose, each time inserting the specific field shape into the computer by a digitizer. The program is based on the implementation of the well known Clarkson's method, exactly as described by Khan(1). The method also allows to calculate the dose under blocks in various depths. In order to verify the validity of the program we compared the calculated dose with that one measured in a waterlike phantom made of white polystyrene (PTW's raw water). The calculation also allows to evaluate the contribution of the scatter radiation to the total dose under the blocks. The dose under two lead blocks was measured within a field of 25x25cm2 as measured on the level of isocenter. The size of blocks as compared to the open field is shown in fig.2. The depths of measurements were dmax, 5cm, 10cm and 20 cm (point B in fig2.). The results are expressed in % with respect to the reference point in dmax (point A in fig.2) and are shown in table 1 (Cobalt gamma rays), in table 2 (6MV X rays) and in table 3 (18MV X rays). The fractions shown in brackets represent the contribution of the scattered radiation to the dose under blocks. The results show that the calculation is in excellent agreement with the measurement for small blocks, it somewhat underestimates the dose for large blocks and small depths, but it is satisfactory for the depths greater than 5 cm. The results also show that the contribution of the scattered radiation is essentially higher under small blocks and that it generally increases with the depth. The maximum difference in no case exceeded 2.5 % of the dose in the reference point. From the point of view of radiation protection, this difference can be considered as negligible. On the other hand, from the point of view of radiotherapy the obtained accuracy is

  12. Radiation safety assessment of cobalt 60 external beam radiotherapy using the risk-matrix method

    International Nuclear Information System (INIS)

    External beam radiotherapy is the only practice in which humans are placed directly in a radiation beam with the intention to deliver a very high dose. This is why safety in radiotherapy is very critical, and is a matter of interest to both radiotherapy departments and regulatory bodies. Accidental exposures have occurred throughout the world, thus showing the need for systematic safety assessments, capable to identify preventive measures and to minimize consequences of accidental exposure. Risk-matrix is a systematic approach which combines the relevant event features to assess the overall risk of each particular event. Once an event sequence is identified, questions such as how frequent the event, how severe the potential consequences and how reliable the existing safety measures are answered in a risk-matrix table. The ultimate goal is to achieve that the overall risk for events with severe consequences should always be low o very low. In the present study, the risk-matrix method has been applied to an hypothetical radiotherapy department, which could be equivalent to an upper level hospital of the Ibero American region, in terms of safety checks and preventive measures. The application of the method has identified 76 event sequences and revealed that the hypothetical radiotherapy department is sufficiently protected (low risk) against them, including 23 event sequences with severe consequences. The method has revealed that the risk of these sequences could grow to high level if certain specific preventive measures were degraded with time. This study has identified these preventive measures, thus facilitating a rational allocation of resources in regular controls to detect any loss of reliability. The method has proven to have an important practical value and is affordable at hospital level. The elaborated risk-matrix can be easily adapted to local circumstances, in terms of existing controls and safety measures. This approach can help hospitals to identify

  13. Beam energy considerations for gold nano-particle enhanced radiation treatment

    Energy Technology Data Exchange (ETDEWEB)

    Van den Heuvel, F; Nuyts, S [Department of Experimental Radiotherapy, University of Leuven, Leuven (Belgium); Locquet, Jean-Pierre, E-mail: frank.vandenheuvel@med.kuleuven.b [Solid State Physics and Magnetism Section, University of Leuven, Leuven (Belgium)

    2010-08-21

    A novel approach using nano-technology enhanced radiation modalities is investigated. The proposed methodology uses antibodies labeled with organically inert metals with a high atomic number. Irradiation using photons with energies in the kilo-electron volt (keV) range shows an increase in dose due to a combination of an increase in photo-electric interactions and a pronounced generation of Auger and/or Coster-Kroenig (A-CK) electrons. The dependence of the dose deposition on various factors is investigated using Monte Carlo simulation models. The factors investigated include agent concentration, spectral dependence looking at mono-energetic sources as well as classical bremsstrahlung sources. The optimization of the energy spectrum is performed in terms of physical dose enhancement as well as the dose deposited by Auger and/or Coster-Kroenig electrons and their biological effectiveness. A quasi-linear dependence on concentration and an exponential decrease within the target medium is observed. The maximal dose enhancement is dependent on the position of the target in the beam. Apart from irradiation with low-photon energies (10-20 keV) there is no added benefit from the increase in generation of Auger electrons. Interestingly, a regular 110 kVp bremsstrahlung spectrum shows a comparable enhancement in comparison with the optimized mono-energetic sources. In conclusion we find that the use of enhanced nano-particles shows promise to be implemented quite easily in regular clinics on a physical level due to the advantageous properties in classical beams.

  14. Beam energy considerations for gold nano-particle enhanced radiation treatment

    Science.gov (United States)

    Van den Heuvel, F.; Locquet, Jean-Pierre; Nuyts, S.

    2010-08-01

    A novel approach using nano-technology enhanced radiation modalities is investigated. The proposed methodology uses antibodies labeled with organically inert metals with a high atomic number. Irradiation using photons with energies in the kilo-electron volt (keV) range shows an increase in dose due to a combination of an increase in photo-electric interactions and a pronounced generation of Auger and/or Coster-Krönig (A-CK) electrons. The dependence of the dose deposition on various factors is investigated using Monte Carlo simulation models. The factors investigated include agent concentration, spectral dependence looking at mono-energetic sources as well as classical bremsstrahlung sources. The optimization of the energy spectrum is performed in terms of physical dose enhancement as well as the dose deposited by Auger and/or Coster-Krönig electrons and their biological effectiveness. A quasi-linear dependence on concentration and an exponential decrease within the target medium is observed. The maximal dose enhancement is dependent on the position of the target in the beam. Apart from irradiation with low-photon energies (10-20 keV) there is no added benefit from the increase in generation of Auger electrons. Interestingly, a regular 110 kVp bremsstrahlung spectrum shows a comparable enhancement in comparison with the optimized mono-energetic sources. In conclusion we find that the use of enhanced nano-particles shows promise to be implemented quite easily in regular clinics on a physical level due to the advantageous properties in classical beams.

  15. Contribution to the beam plasma material interactions during material processing with TEA CO2 laser radiation

    Science.gov (United States)

    Jaschek, Rainer; Konrad, Peter E.; Mayerhofer, Roland; Bergmann, Hans W.; Bickel, Peter G.; Kowalewicz, Roland; Kuttenberger, Alfred; Christiansen, Jens

    1995-03-01

    The TEA-CO2-laser (transversely excited atmospheric pressure) is a tool for the pulsed processing of materials with peak power densities up to 1010 W/cm2 and a FWHM of 70 ns. The interaction between the laser beam, the surface of the work piece and the surrounding atmosphere as well as gas pressure and the formation of an induced plasma influences the response of the target. It was found that depending on the power density and the atmosphere the response can take two forms. (1) No target modification due to optical break through of the atmosphere and therefore shielding of the target (air pressure above 10 mbar, depending on the material). (2) Processing of materials (air pressure below 10 mbar, depending on the material) with melting of metallic surfaces (power density above 0.5 109 W/cm2), hole formation (power density of 5 109 W/cm2) and shock hardening (power density of 3.5 1010 W/cm2). All those phenomena are usually linked with the occurrence of laser supported combustion waves and laser supported detonation waves, respectively for which the mechanism is still not completely understood. The present paper shows how short time photography and spatial and temporal resolved spectroscopy can be used to better understand the various processes that occur during laser beam interaction. The spectra of titanium and aluminum are observed and correlated with the modification of the target. If the power density is high enough and the gas pressure above a material and gas composition specific threshold, the plasma radiation shows only spectral lines of the background atmosphere. If the gas pressure is below this threshold, a modification of the target surface (melting, evaporation and solid state transformation) with TEA-CO2- laser pulses is possible and the material specific spectra is observed. In some cases spatial and temporal resolved spectroscopy of a plasma allows the calculation of electron temperatures by comparison of two spectral lines.

  16. Intensity Modulated Proton Beam Radiation for Brachytherapy in Patients With Cervical Carcinoma

    International Nuclear Information System (INIS)

    Purpose: To evaluate intensity modulated proton therapy (IMPT) in patients with cervical cancer in terms of coverage, conformity, and dose–volume histogram (DVH) parameters correlated with recommendations from magnetic resonance imaging (MRI)-guided brachytherapy. Methods and Materials: Eleven patients with histologically proven cervical cancer underwent primary chemoradiation for the pelvic lymph nodes, the uterus, the cervix, and the parametric region, with a symmetric margin of 1 cm. The prescription was for 50.4 Gy, with 1.8 Gy per fraction. The prescribed dose to the parametria was 2.12 Gy up to 59.36 Gy in 28 fractions as a simultaneous boost. For several reasons, the patients were unable to undergo brachytherapy. As an alternative, IMPT was planned with 5 fractions of 6 Gy to the cervix, including the macroscopic tumor with an MRI-guided target definition, with an isotropic margin of 5 mm for planning target volume (PTV) definition. Groupe-Europeen de Curietherapie and European society for Radiotherapy and Oncology (GEC-ESTRO) criteria were used for DVH evaluation. Reference comparison plans were optimized for volumetric modulated rapid arc (VMAT) therapy with the RapidArc (RA). Results: The dose to the high-risk volume was calculated with α/β = 10 with 89.6 Gy. For IMPT, the clinical target volume showed a mean dose of 38.2 ± 5.0 Gy (35.0 ±1.8 Gy for RA). The D98% was 31.9 ± 2.6 Gy (RA: 30.8 ± 1.0 Gy). With regard to the organs at risk, the 2Gy Equivalent Dose (EQD2) (α/β = 3) to 2 cm3 of the rectal wall, sigmoid wall, and bladder wall was 62.2 ± 6.4 Gy, 57.8 ± 6.1 Gy, and 80.6 ± 8.7 Gy (for RA: 75.3 ± 6.1 Gy, 66.9 ± 6.9 Gy, and 89.0 ± 7.2 Gy, respectively). For the IMPT boost plans in combination with external beam radiation therapy, all DVH parameters correlated with <5% risk for grades 2 to 4 late gastrointestinal and genitourinary toxicity. Conclusion: In patients who are not eligible for brachytherapy, IMPT as a boost technique

  17. Intensity Modulated Proton Beam Radiation for Brachytherapy in Patients With Cervical Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Clivio, Alessandro [Oncology Institute of Southern Switzerland, Bellinzona (Switzerland); Kluge, Anne [Department of Radiation Oncology, Charité University Hospital, Berlin (Germany); Cozzi, Luca, E-mail: lucozzi@iosi.ch [Oncology Institute of Southern Switzerland, Bellinzona (Switzerland); Köhler, Christhardt [Department of Gynecology, Charité University Hospital, Berlin (Germany); Neumann, Oliver [Department of Radiation Oncology, Charité University Hospital, Berlin (Germany); Vanetti, Eugenio [Oncology Institute of Southern Switzerland, Bellinzona (Switzerland); Wlodarczyk, Waldemar; Marnitz, Simone [Department of Radiation Oncology, Charité University Hospital, Berlin (Germany)

    2013-12-01

    Purpose: To evaluate intensity modulated proton therapy (IMPT) in patients with cervical cancer in terms of coverage, conformity, and dose–volume histogram (DVH) parameters correlated with recommendations from magnetic resonance imaging (MRI)-guided brachytherapy. Methods and Materials: Eleven patients with histologically proven cervical cancer underwent primary chemoradiation for the pelvic lymph nodes, the uterus, the cervix, and the parametric region, with a symmetric margin of 1 cm. The prescription was for 50.4 Gy, with 1.8 Gy per fraction. The prescribed dose to the parametria was 2.12 Gy up to 59.36 Gy in 28 fractions as a simultaneous boost. For several reasons, the patients were unable to undergo brachytherapy. As an alternative, IMPT was planned with 5 fractions of 6 Gy to the cervix, including the macroscopic tumor with an MRI-guided target definition, with an isotropic margin of 5 mm for planning target volume (PTV) definition. Groupe-Europeen de Curietherapie and European society for Radiotherapy and Oncology (GEC-ESTRO) criteria were used for DVH evaluation. Reference comparison plans were optimized for volumetric modulated rapid arc (VMAT) therapy with the RapidArc (RA). Results: The dose to the high-risk volume was calculated with α/β = 10 with 89.6 Gy. For IMPT, the clinical target volume showed a mean dose of 38.2 ± 5.0 Gy (35.0 ±1.8 Gy for RA). The D{sub 98%} was 31.9 ± 2.6 Gy (RA: 30.8 ± 1.0 Gy). With regard to the organs at risk, the 2Gy Equivalent Dose (EQD2) (α/β = 3) to 2 cm{sup 3} of the rectal wall, sigmoid wall, and bladder wall was 62.2 ± 6.4 Gy, 57.8 ± 6.1 Gy, and 80.6 ± 8.7 Gy (for RA: 75.3 ± 6.1 Gy, 66.9 ± 6.9 Gy, and 89.0 ± 7.2 Gy, respectively). For the IMPT boost plans in combination with external beam radiation therapy, all DVH parameters correlated with <5% risk for grades 2 to 4 late gastrointestinal and genitourinary toxicity. Conclusion: In patients who are not eligible for brachytherapy, IMPT as a boost

  18. Gamma, electron beam and ultraviolet radiation on control of storage rots and quality of Walla Walla onions

    International Nuclear Information System (INIS)

    Walla Walla onions were irradiated with doses of 0.1, 0.3, 1.0, 2.0 and 3.0 kGy of gamma rays; 0.1, 1.0, 2.0, 3.0 and 5.0 kGy of electron beams; or 0.44 × 104 1.32 × 104, 3.52 × 104, 7.33 × 104 and 19.1 × 104 erg/mm± of UV. The onions were stored up to four weeks at 20–25 C. UV irradiated onions exhibited the greatest percentage of marketable onions and reduction in postharvest rots. Sprouting was obsened with control, UV and electron beam irradiated onions but not with gamma irradiated onions. Effect of gamma, electron beams and UV on pH, moisture, ascorbic acid and color were not significant. Onions became soft with the high dose of gamma radiation (3.0 kGy). Total sugar content was not affected by UV and electron beam but tended to be greatest at the 1.0 kGy gamma radiation. The effect of the radiation on the onion sensory scores was not clearly indicated except that 3.0 kGy gamma ray irradiated onions had the lowest firmness score

  19. Microdosimetric assessment of the radiation quality of a therapeutic proton beam: Comparison between numerical simulation and experimental measurements

    International Nuclear Information System (INIS)

    Using protons for the treatment of ocular melanoma (especially of posterior pole tumours), the radiation quality of the beam must be precisely assessed to preserve the vision and to minimise the damage to healthy tissue. The radiation quality of a therapeutic proton beam at the Centre Antoine Lacassagne in Nice (France) was measured using microdosimetric techniques, i.e. a miniaturised version of a tissue-equivalent proportional counter. Measurements were performed in a 1-μm site at different depths in a Lucite phantom. Experimental data showed a significant increase in the beam quality at the distal edge of the spread-out Bragg peak (SOBP). In this paper, the numerical simulation of the experimental setup is done with the FLUKA Monte Carlo radiation transport code. The calculated microdosimetric spectra are compared with the measured ones at different depths in tissue for a monoenergetic proton beam (E=62 MeV) and for a modulated SOBP. Numerically and experimentally predicted relative biological effectiveness values are in good agreement. The calculated frequency-averaged and dose-averaged lineal energy mean values are consistent with measured data. (authors)

  20. Beam-excited whistler waves at oblique propagation with relation to STEREO radiation belt observations

    Directory of Open Access Journals (Sweden)

    K. Sauer

    2010-06-01

    Full Text Available Isotropic electron beams are considered to explain the excitation of whistler waves which have been observed by the STEREO satellite in the Earth's radiation belt. Aside from their large amplitudes (~240 mV/m, another main signature is the strongly inclined propagation direction relative to the ambient magnetic field. Electron temperature anisotropy with Te⊥>Te||, which preferentially generates parallel propagating whistler waves, can be excluded as a free energy source. The instability arises due to the interaction of the Doppler-shifted cyclotron mode ω=−Ωe+kVbcosθ with the whistler mode in the wave number range of kce≤1 (θ is the propagation angle with respect to the background magnetic field direction, ωe is the electron plasma frequency and Ωe the electron cyclotron frequency. Fluid and kinetic dispersion analysis have been used to calculate the growth rate of the beam-excited whistlers including the most important parameter dependencies. One is the beam velocity (Vb which, for instability, has to be larger than about 2VAe, where VAe is the electron Alfvén speed. With increasing VAe the propagation angle (θ of the fastest growing whistler waves shifts from θ~20° for Vb=2VAe to θ~80° for Vb=5VAe. The growth rate is reduced by finite electron temperatures and disappears if the electron plasma beta (βe exceeds βe~0.2. In addition, Gendrin modes (kce≈1 are analyzed to determine the conditions under which stationary nonlinear waves (whistler oscillitons can exist. The corresponding spatial wave profiles are calculated using the full nonlinear fluid approach. The results are compared with the STEREO satellite observations.

  1. An investigation of the adjoint method for external beam radiation therapy treatment planning using Monte Carlo transport

    International Nuclear Information System (INIS)

    A relatively new technique for achieving the right dose to the right tissue, is intensity modulated radiation therapy (IMRT). In this technique, a megavoltage x-ray beam is rotated around a patient, and the intensity and shape of the beam is modulated as a function of source position and patient anatomy. The relationship between beam-let intensity and patient dose can be expressed under a matrix form where the matrix Dij represents the dose delivered to voxel i by beam-let j per unit fluence. The Dij influence matrix is the key element that enables this approach. In this regard, sensitivity theory lends itself in a natural way to the process of computing beam weights for treatment planning. The solution of the adjoint form of the Boltzmann equation is an adjoint function that describes the importance of particles throughout the system in contributing to the detector response. In this case, adjoint methods can provide the sensitivity of the dose at a single point in the patient with respect to all points in the source field. The purpose of this study is to investigate the feasibility of using the adjoint method and Monte Carlo transport for radiation therapy treatment planning

  2. Targeted Intraoperative Radiotherapy for Breast Cancer in Patients in Whom External Beam Radiation Is Not Possible

    International Nuclear Information System (INIS)

    Purpose: External beam radiation therapy (EBRT) following wide local excision of the primary tumor is the standard treatment in early breast cancer. In some circumstances this procedure is not possible or is contraindicated or difficult. The purpose of this study was to determine the safety and efficacy of targeted intraoperative radiotherapy (TARGIT) when EBRT is not feasible. Methods and Materials: We report our experience with TARGIT in three centers (Australia, Germany, and the United Kingdom) between 1999 and 2008. Patients at these centers received a single radiation dose of 20 Gy to the breast tissue in contact with the applicator (or 6 Gy at 1-cm distance), as they could not be given EBRT and were keen to avoid mastectomy. Results: Eighty patients were treated with TARGIT. Reasons for using TARGIT were 21 patients had previously received EBRT, and 31 patients had clinical reasons such as systemic lupus erythematosus, motor neuron disease, Parkinson's disease, ankylosing spondylitis, morbid obesity, and cardiovascular or severe respiratory disease. Three of these patients received percutaneous radiotherapy without surgery; 28 patients were included for compelling personal reasons, usually on compassionate grounds. After a median follow-up of 38 months, only two local recurrences were observed, an annual local recurrence rate of 0.75% (95% confidence interval, 0.09%-2.70%). Conclusions: While we await the results of the randomized trial (over 2,000 patients have already been recruited), TARGIT is an acceptable option but only in highly selected cases that cannot be recruited in the trial and in whom EBRT is not feasible/possible.

  3. Ionizing radiation effect study by electron beam on acrylonitrile butadiene styrene - ABS terpolymer

    International Nuclear Information System (INIS)

    The great advantage in the researches involving development has as objective to increase significantly the quality of the products. The ABS (acrylonitrile, butadiene, styrene) resins are terpolymers formed by an elastomer and two thermoplastics amorphous components. The three different monomeric units from the terpolymer ABS contribute separately to the material characteristics exhibited. The molecular stiffness originating from polystyrene and the benzene ring hanging on the chain is responsible for the flexion module ABS. The acrylonitrile and the styrene incorporated butadiene exercises strong influence in the resistance to the impact because it reduces the bonding among them. The engineering use of this terpolymer became important due their mechanical properties and mainly, for the responses of this to tensions or deformations applied. The polymeric materials, when submitted to the ionizing radiation are modified by the transference of energy to these materials, introducing excitation and ionization of the molecules, generating chemical reactions that can produce permanent modifications in the polymeric physicochemical structure. The induced modifications can result in the polymeric material degradation or crosslinking, which can result in the improvement of some properties. This work has, as objective, to study the electron beam ionizing radiation effect, at different doses, in the properties of the polymer ABS. The studied properties were: tensile strength at break, elongation at break, Izod impact strength, flexural strength, melt flow index, Vicat softening temperature and the thermic distortion temperature. Also researches on Differential Scanning Calorimetry (DSC) and Thermogravimetric Analyses (TGA) were accomplished. From the experimental results, it was showed that for doses until 500 kGy, at 22.6 kGy/s dose rate, in the presence of air, the crosslinking process of ABS prevails. (author)

  4. Adaptive planning using megavoltage fan-beam CT for radiation therapy with testicular shielding

    Energy Technology Data Exchange (ETDEWEB)

    Yadav, Poonam [Department of Human Oncology, University of Wisconsin, Madison, Madison, WI (United States); Department of Medical Physics, University of Wisconsin, Madison, Madison, WI (United States); School of Advance Sciences, Vellore Institue of Technology University, Vellore, Tamil Nadu (India); Kozak, Kevin [Department of Human Oncology, University of Wisconsin, Madison, Madison, WI (United States); Tolakanahalli, Ranjini [Department of Human Oncology, University of Wisconsin, Madison, Madison, WI (United States); Department of Medical Physics, University of Wisconsin, Madison, Madison, WI (United States); Ramasubramanian, V. [School of Advance Sciences, Vellore Institue of Technology University, Vellore, Tamil Nadu (India); Paliwal, Bhudatt R. [Department of Human Oncology, University of Wisconsin, Madison, Madison, WI (United States); Department of Medical Physics, University of Wisconsin, Madison, Madison, WI (United States); University of Wisconsin, Riverview Cancer Centre, Wisconsin Rapids, WI (United States); Welsh, James S. [Department of Human Oncology, University of Wisconsin, Madison, Madison, WI (United States); Department of Medical Physics, University of Wisconsin, Madison, Madison, WI (United States); Rong, Yi, E-mail: rong@humonc.wisc.edu [Department of Human Oncology, University of Wisconsin, Madison, Madison, WI (United States); University of Wisconsin, Riverview Cancer Centre, Wisconsin Rapids, WI (United States)

    2012-07-01

    This study highlights the use of adaptive planning to accommodate testicular shielding in helical tomotherapy for malignancies of the proximal thigh. Two cases of young men with large soft tissue sarcomas of the proximal thigh are presented. After multidisciplinary evaluation, preoperative radiation therapy was recommended. Both patients were referred for sperm banking and lead shields were used to minimize testicular dose during radiation therapy. To minimize imaging artifacts, kilovoltage CT (kVCT) treatment planning was conducted without shielding. Generous hypothetical contours were generated on each 'planning scan' to estimate the location of the lead shield and generate a directionally blocked helical tomotherapy plan. To ensure the accuracy of each plan, megavoltage fan-beam CT (MVCT) scans were obtained at the first treatment and adaptive planning was performed to account for lead shield placement. Two important regions of interest in these cases were femurs and femoral heads. During adaptive planning for the first patient, it was observed that the virtual lead shield contour on kVCT planning images was significantly larger than the actual lead shield used for treatment. However, for the second patient, it was noted that the size of the virtual lead shield contoured on the kVCT image was significantly smaller than the actual shield size. Thus, new adaptive plans based on MVCT images were generated and used for treatment. The planning target volume was underdosed up to 2% and had higher maximum doses without adaptive planning. In conclusion, the treatment of the upper thigh, particularly in young men, presents several clinical challenges, including preservation of gonadal function. In such circumstances, adaptive planning using MVCT can ensure accurate dose delivery even in the presence of high-density testicular shields.

  5. Radiation dose evaluation of dental cone beam computed tomography using an anthropomorphic adult head phantom

    International Nuclear Information System (INIS)

    Dental cone beam computed tomography (CBCT) provides high-resolution tomographic images and has been gradually used in clinical practice. Thus, it is important to examine the amount of radiation dose resulting from dental CBCT examinations. In this study, we developed an in-house anthropomorphic adult head phantom to evaluate the level of effective dose. The anthropomorphic phantom was made of acrylic and filled with plaster to replace the bony tissue. The contour of the head was extracted from a set of adult computed tomography (CT) images. Different combinations of the scanning parameters of CBCT were applied. Thermoluminescent dosimeters (TLDs) were used to measure the absorbed doses at 19 locations in the head and neck regions. The effective doses measured using the proposed phantom at 65, 75, and 85 kVp in the D-mode were 72.23, 100.31, and 134.29 µSv, respectively. In the I-mode, the effective doses were 108.24, 190.99, and 246.48 µSv, respectively. The maximum percent error between the doses measured by the proposed phantom and the Rando phantom was l4.90%. Therefore, the proposed anthropomorphic adult head phantom is applicable for assessing the radiation dose resulting from clinical dental CBCT. - Highlights: • A home-made anthropomorphic adult head phantom was proposed. • The proposed phantom can be easily built with lower price than the standard Rando phantom. • The proposed phantom can be used for evaluating the effective dose during dental CBCT scanning

  6. External beam radiation attenuates venous neointimal hyperplasia in a pig model of arteriovenous polytetrafluoroethylene (PTFE) graft stenosis

    International Nuclear Information System (INIS)

    Purpose: Hemodialysis vascular access dysfunction is an enormous clinical problem that causes great morbidity and costs well over one billion dollars per annum. The vast majority of hemodialysis vascular access dysfunction occurs as a result of venous stenosis and thrombosis at the graft-vein anastomosis. At a cellular level, this venous stenosis is the result of venous neointimal hyperplasia (VNH). There are, unfortunately, no effective therapies for VNH. The purpose of this study was to assess the role of external radiation therapy in preventing VNH and venous stenosis. Methods and Materials: Seven-centimeter polytetrafluoroethylene loop grafts were placed bilaterally between the femoral artery and vein of 12 Yorkshire Cross pigs. One side was treated with a single 16-Gy dose of external beam radiation with a linear accelerator, while the contralateral side served as an internal control. Swine were killed after 28 days, and the grafts were carefully dissected out and removed. Neointimal hyperplasia and luminal stenosis were then assessed morphometrically at the graft-vessel anastomoses. Results: External beam radiation therapy significantly reduced the amount of luminal stenosis at the graft-vein anastomosis, with minimal local and systemic toxicity. Conclusions: External beam radiation therapy could be a useful and clinically relevant local treatment for venous stenosis in polytetrafluoroethylene dialysis grafts

  7. Study of the measurement of critical parameters in an electron beam radiation facility. Application to the case of the first accelerator dedicated to radiation in Tunisia

    International Nuclear Information System (INIS)

    The Tunisian National Center for Nuclear Sciences and Technologies will acquire the first North African Radio Frequency linear accelerator of electrons in 2009. The facility will be designed primarily for sterilization of medical devices and preservation of foodstuff. The first part of this paper is dedicated to a description of the facility. In order to adjust the treatment conditions and to control the good operation of the accelerator, it is necessary to find out several electron beam parameters. The second part of the paper is devoted to the presentation of the system dedicated to determining several key parameters of the electron beam. The performances and advantages of the diagnostic system cited in this report make it quite suitable for process control application at an electron beam radiation processing facility.

  8. Study of the measurement of critical parameters in an electron beam radiation facility. Application to the case of the first accelerator dedicated to radiation in Tunisia

    Energy Technology Data Exchange (ETDEWEB)

    M' Garrech, S. [Laboratoire de Radio-traitement, Centre National des Sciences et Technologies Nucleaires, 2020 Sidi-Thabet (Tunisia)], E-mail: mgslah@yahoo.fr; Ezzouch, A. [Institut National des Sciences Appliquees et de Technologie, 1080 Tunis (Tunisia)

    2009-02-15

    The Tunisian National Center for Nuclear Sciences and Technologies will acquire the first North African Radio Frequency linear accelerator of electrons in 2009. The facility will be designed primarily for sterilization of medical devices and preservation of foodstuff. The first part of this paper is dedicated to a description of the facility. In order to adjust the treatment conditions and to control the good operation of the accelerator, it is necessary to find out several electron beam parameters. The second part of the paper is devoted to the presentation of the system dedicated to determining several key parameters of the electron beam. The performances and advantages of the diagnostic system cited in this report make it quite suitable for process control application at an electron beam radiation processing facility.

  9. Measuring radiation damage dynamics by pulsed ion beam irradiation. 2015 Annual Progress Report for DOE/NE/NEET

    International Nuclear Information System (INIS)

    The major goal of this project is to develop and demonstrate a novel experimental approach to access the dynamic regime of radiation damage formation processes in nuclear materials. In particular, the project exploits a pulsed-ion-beam method in order to gain insight into defect interaction dynamics by measuring effective defect interaction time constants and defect diffusion lengths. For Year 2, this project had the following two major milestones: (i) measurement of the temperature dependence of defect dynamics in SiC and (ii) the evaluation of the robustness of the pulsed beam method from studies of the defect generation rate. As we describe below, both of these milestones have been met.

  10. Measuring radiation damage dynamics by pulsed ion beam irradiation. 2015 Annual Progress Report for DOE/NE/NEET

    Energy Technology Data Exchange (ETDEWEB)

    Kucheyev, S. O. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-03-07

    The major goal of this project is to develop and demonstrate a novel experimental approach to access the dynamic regime of radiation damage formation processes in nuclear materials. In particular, the project exploits a pulsed-ion-beam method in order to gain insight into defect interaction dynamics by measuring effective defect interaction time constants and defect diffusion lengths. For Year 2, this project had the following two major milestones: (i) measurement of the temperature dependence of defect dynamics in SiC and (ii) the evaluation of the robustness of the pulsed beam method from studies of the defect generation rate. As we describe below, both of these milestones have been met.

  11. Self-consistent simulation of radiation and space-charge in high-brightness relativistic electron beams

    Science.gov (United States)

    Gillingham, David R.

    2007-12-01

    The ability to preserve the quality of relativistic electron beams through transport bend elements such as a bunch compressor chicane is increasingly difficult as the current increases because of effects such as coherent synchrotron radiation (CSR) and space-charge. Theoretical CSR models and simulations, in their current state, often make unrealistic assumptions about the beam dynamics and/or structures. Therefore, we have developed a model and simulation that contains as many of these elements as possible for the purpose of making high-fidelity end-to-end simulations. Specifically, we are able to model, in a completely self-consistent, three-dimensional manner, the sustained interaction of radiation and space-charge from a relativistic electron beam in a toroidal waveguide with rectangular cross-section. We have accomplished this by combining a time-domain field solver that integrates a paraxial wave equation valid in a waveguide when the dimensions are small compared to the bending radius with a particle-in-cell dynamics code. The result is shown to agree with theory under a set of constraints, namely thin rigid beams, showing the stimulation resonant modes and including comparisons for waveguides approximating vacuum, and parallel plate shielding. Using a rigid beam, we also develop a scaling for the effect of beam width, comparing both our simulation and numerical integration of the retarded potentials. We further demonstrate the simulation calculates the correct longitudinal space-charge forces to produce the appropriate potential depression for a converging beam in a straight waveguide with constant dimensions. We then run fully three-dimensional, self-consistent end-to-end simulations of two types of bunch compressor designs, illustrating some of the basic scaling properties and perform a detailed analysis of the output phase-space distribution. Lastly, we show the unique ability of our simulation to model the evolution of charge/energy perturbations on a

  12. PSA bounces after neoadjuvant androgen deprivation and external beam radiation: Impact on definitions of failure

    International Nuclear Information System (INIS)

    Purpose: To determine the characteristics of prostate specific antigen (PSA) bounces after external beam radiation therapy (EBRT) with neoadjuvant androgen deprivation and their impact on definitions of biochemical failure. Methods and Materials: Characteristics of bounce were calculated for all patients treated by EBRT with neoadjuvant androgen deprivation at our institution between 1992 and 1998 (preexclusion analysis). Calculations were repeated for the subgroup that satisfied additional inclusion/exclusion criteria (postexclusion analysis). The percentage of bounces scoring as false positives according to the ASTRO definition of biochemical failure was compared with those for three alternative definitions (Vancouver, Nadir-plus-two, and Nadir-plus-three) using McNemar's tests. Results: Thirty-nine percent (preexclusion cohort) and 56% (postexclusion cohort) of patients demonstrated a PSA bounce. Twenty percent (preexclusion analysis) and 25% (postexclusion analysis) of these bounces scored as biochemical failure according to the ASTRO definition. The Nadir-plus-three definition scored the smallest percentage of bounces as failure, but the difference between this definition and the ASTRO definition reached statistical significance in neither preexclusion nor postexclusion analyses (p ≥ 0.070). Conclusions: A substantial proportion of patients treated by EBRT with neoadjuvant deprivation experienced a PSA bounce. A large percentage of these bounces scored as biochemical failure according to the ASTRO definition. The Nadir-plus-three definition is less vulnerable to this bias

  13. Wettability modification of human tooth surface by water and UV and electron-beam radiation

    Energy Technology Data Exchange (ETDEWEB)

    Tiznado-Orozco, Gaby E., E-mail: gab0409@gmail.com [UMET, Bâtiment C6, Université de Lille 1, Sciences et Technologies, 59650 Villeneuve d' Ascq (France); Unidad Académica de Odontología, Universidad Autónoma de Nayarit, Edificio E7, Ciudad de la Cultura “Amado Nervo”, C.P. 63190 Tepic, Nayarit (Mexico); Reyes-Gasga, José, E-mail: jreyes@fisica.unam.mx [UMET, Bâtiment C6, Université de Lille 1, Sciences et Technologies, 59650 Villeneuve d' Ascq (France); Instituto de Física, UNAM, Circuito de la Investigación s/n, Ciudad Universitaria, 04510 Coyoacan, México, D.F. (Mexico); Elefterie, Florina, E-mail: elefterie_florina@yahoo.com [UMET, Bâtiment C6, Université de Lille 1, Sciences et Technologies, 59650 Villeneuve d' Ascq (France); Beyens, Christophe, E-mail: christophe.beyens@ed.univ-lille1.fr [UMET, Bâtiment C6, Université de Lille 1, Sciences et Technologies, 59650 Villeneuve d' Ascq (France); Maschke, Ulrich, E-mail: Ulrich.Maschke@univ-lille1.fr [UMET, Bâtiment C6, Université de Lille 1, Sciences et Technologies, 59650 Villeneuve d' Ascq (France); Brès, Etienne F., E-mail: etienne.bres@univ-lille1.fr [UMET, Bâtiment C6, Université de Lille 1, Sciences et Technologies, 59650 Villeneuve d' Ascq (France)

    2015-12-01

    The wettability of the human tooth enamel and dentin was analyzed by measuring the contact angles of a drop of distilled water deposited on the surface. The samples were cut along the transverse and longitudinal directions, and their surfaces were subjected to metallographic mirror-finish polishing. Some samples were also acid etched until their microstructure became exposed. Wettability measurements of the samples were done in dry and wet conditions and after ultraviolet (UV) and electron beam (EB) irradiations. The results indicate that water by itself was able to increase the hydrophobicity of these materials. The UV irradiation momentarily reduced the contact angle values, but they recovered after a short time. EB irradiation raised the contact angle and maintained it for a long time. Both enamel and dentin surfaces showed a wide range of contact angles, from approximately 10° (hydrophilic) to 90° (hydrophobic), although the contact angle showed more variability on enamel than on dentin surfaces. Whether the sample's surface had been polished or etched did not influence the contact angle value in wet conditions. - Highlights: • Human tooth surface wettability changes in dry/wet and UV/EB radiation conditions. • More variability in contact angle is observed on enamel than on dentin surfaces. • Water by itself increases the hydrophobicity of the human tooth surface. • UV irradiation reduces momentarily the human tooth surface hydrophobicity. • EB irradiation increases and maintains the hydrophobicity for a long time.

  14. Carboxymethyl starch cross-linked by electron beam radiation in presence of acrylic acid sensitizer

    International Nuclear Information System (INIS)

    Carboxymethyl starch (CMS) can be cross-linked by electron beam radiation to form a biocompatible and environment-friendly hydrogel at a high absorbed dose and a condensed CMS concentration. Acrylic acid (AAc) can be used as a sensitizer in order to reduce the absorbed doses to an acceptable certain level. At an absorbed dose of 3-4 kGy, the gel content of crosslinked CMS can be obtained about 50% with 5% (w/w) AAc concentration used. The compressive strength of CMS samples increased with increasing their cross-linked densities due to raising absorbed doses. The swelling ratio of cross-linked CMS was also attainable at a maximum of 50 times in the distilled water. The enzymatic degradation of cross-linked CMS was carried out in acetate buffer pH 4.6 with 0.1% α-amylase enzymatic solution incubated at 40℃ for 6 h. The crosslinked CMS samples were degraded slower than uncrosslinked CMS ones. The results indicated that the highly cross-linked CMS was almost fully degradable when the enzymatic hydrolysis was performed during 6 h. The FT IR spectra of cross-linked CMS in the presence of AAc were examined to observe the carboxyl group of AAc in the structure of cross-linked CMS. The hydrophilic of cross-linked CMS surface was determined by a contact-angle analysis. (authors)

  15. Applications of pixellated GaAs X-ray detectors in a synchrotron radiation beam

    CERN Document Server

    Watt, J; Campbell, M; Mathieson, K; Mikulec, B; O'Shea, V; Passmore, M S; Schwarz, C; Smith, K M; Whitehill, C

    2001-01-01

    Hybrid semiconductor pixel detectors are being investigated as imaging devices for radiography and synchrotron radiation beam applications. Based on previous work in the CERN RD19 and the UK IMPACT collaborations, a photon counting GaAs pixel detector (PCD) has been used in an X-ray powder diffraction experiment. The device consists of a 200 mu m thick SI-LEC GaAs detector patterned in a 64*64 array of 170 mu m pitch square pixels, bump-bonded to readout electronics operating in single photon counting mode. Intensity peaks in the powder diffraction pattern of KNbO/sub 3/ have been resolved and compared with results using the standard scintillator, and a PCD predecessor (the Omega 3). The PCD shows improved speed, dynamic range, 2-D information and comparable spatial resolution to the standard scintillator based systems. It also overcomes the severe dead time limitations of the Omega 3 by using a shutter based acquisition mode. A brief demonstration of the possibilities of the system for dental radiography and...

  16. Applications of pixellated GaAs X-ray detectors in a synchrotron radiation beam

    Science.gov (United States)

    Watt, J.; Bates, R.; Campbell, M.; Mathieson, K.; Mikulec, B.; O'Shea, V.; Passmore, M.-S.; Schwarz, C.; Smith, K. M.; Whitehill, C.; XIMAGE Project

    2001-03-01

    Hybrid semiconductor pixel detectors are being investigated as imaging devices for radiography and synchrotron radiation beam applications. Based on previous work in the CERN RD19 and the UK IMPACT collaborations, a photon counting GaAs pixel detector (PCD) has been used in an X-ray powder diffraction experiment. The device consists of a 200 μm thick SI-LEC GaAs detector patterned in a 64×64 array of 170 μm pitch square pixels, bump-bonded to readout electronics operating in single photon counting mode. Intensity peaks in the powder diffraction pattern of KNbO 3 have been resolved and compared with results using the standard scintillator, and a PCD predecessor (the Ω3). The PCD shows improved speed, dynamic range, 2-D information and comparable spatial resolution to the standard scintillator based systems. It also overcomes the severe dead time limitations of the Ω3 by using a shutter based acquisition mode. A brief demonstration of the possibilities of the system for dental radiography and image processing are given, showing a marked reduction in patient dose and dead time compared with film.

  17. Coupled electron beam radiation and MBR treatment of textile wastewater containing polyvinyl alcohol.

    Science.gov (United States)

    Sun, Weihua; Chen, Jun; Chen, Lujun; Wang, Jianlong; Zhang, Yongming

    2016-07-01

    Advanced oxidation processes (AOP) can be combined with biological treatments for recalcitrant organic pollutant decomposition. However, there has been no thorough investigation on the coupling of AOPs and membrane bioreactors (MBR) to treat polymer organic pollutants. This study proposes a new AOP that couples electron beam (EB) radiation and MBR treatment. This method was applied to treat real textile effluents containing polyvinyl alcohol (PVA). During the stable operation stage, 31 ± 7% (n = 28) COD was removed by the EB-MBR process. COD removal was enhanced to 45% at the end of the research period without process optimization. In addition, both the membrane flux and activated sludge system exhibited good stability. Only a 2% membrane flux decreased was observed after a 46 d operation period. PVA radiolysis and biofacies analysis mechanisms are also discussed. By contrast, PVA degradation using only the MBR treatment was ineffective in this study. This ineffectiveness was caused by membrane interception and floccule formation by PVA and activated sludge. PMID:27107385

  18. Radiation response of multi-quantum well solar cells: Electron-beam-induced current analysis

    Energy Technology Data Exchange (ETDEWEB)

    Maximenko, S. I., E-mail: sergey.maximenko@nrl.navy.mil; Scheiman, D. A.; Jenkins, P. P.; Walters, R. J. [Naval Research Laboratory, Washington, DC 20375 (United States); Lumb, M. P.; Hoheisel, R. [The George Washington University, Washington, DC 20052 (United States); Gonzalez, M. [Sotera Defense Solutions, Herndon, Virginia 20171 (United States); Messenger, S. R. [University of Maryland Baltimore County, Baltimore, Maryland 21250 (United States); Tibbits, T. N. D. [QuantaSol Ltd, Kingston-upon-Thames KT1 3GZ (United Kingdom); Imaizumi, M. [Japan Aerospace Exploration Agency (JAXA), Tsukuba, Ibaraki 305-8505 (Japan); Ohshima, T.; Sato, S. I. [Japan Atomic Energy Agency (JAEA), Takasaki, Gunma 370-1292 (Japan)

    2015-12-28

    Solar cells utilizing multi-quantum well (MQW) structures are considered promising candidate materials for space applications. An open question is how well these structures can resist the impact of particle irradiation. The aim of this work is to provide feedback about the radiation response of In{sub 0.01}Ga{sub 0.99}As solar cells grown on Ge with MQWs incorporated within the i-region of the device. In particular, the local electronic transport properties of the MQW i-regions of solar cells subjected to electron and proton irradiation were evaluated experimentally using the electron beam induced current (EBIC) technique. The change in carrier collection distribution across the MQW i-region was analyzed using a 2D EBIC diffusion model in conjunction with numerical modeling of the electrical field distribution. Both experimental and simulated findings show carrier removal and type conversion from n- to p-type in MQW i-region at a displacement damage dose as low as ∼6.06–9.88 × 10{sup 9} MeV/g. This leads to a redistribution of the electric field and significant degradation in charge carrier collection.

  19. Ferrimagnetic oxides: syntheses and radiation effects with GANIL heavy ions beams

    International Nuclear Information System (INIS)

    Radiation effects with G.A.N.I.L. heavy ions beams in magnetic oxides (BaFe12O19, Y3Fe5O12), well known for their industrial applications, have been investigated by magnetization measurements, Moessbauer spectrometry, and high resolution electron microscopy. Structural and magnetic order modifications induced by heavy ion bombardment can lead to amorphous material. Our experimental results have been explained on the basis of different amorphization processes, depending on incident ions (mass, energy) and the nature of the target. With 1.8 GeV argon ions, the evolution of the relative magnetization versus the number of displacements per atoms is the same for BaFe12-O19 and Y3Fe5O12. Amorphization process is closely related to atomic collisions. With 2.9 GeV krypton ions, nuclear stopping power can still explained the amorphization of BaFe12O19. On the other hand, electronic stopping power become great enough to create tracks in Y3Fe5O12. With 3 GeV xenon ions, amorphization process is related to nuclear tracks created in BeFe12O19 and Y3Fe5O12. Structural and magnetic order modifications induced by energetic heavy ions have been investigated in new antiferromagnetic oxides Ba2Sb2M3-Fe8O22 (M=Ni, Co, Mg, Zn) which we have prepared and studied

  20. The geometric calibration of cone-beam imaging and delivery systems in radiation therapy

    CERN Document Server

    Matsinos, E; Kaissl, Wolfgang; Matsinos, Evangelos

    2006-01-01

    We propose a method to achieve the geometric calibration of cone-beam imaging and delivery systems in radiation therapy; our approach applies to devices where an X-ray source and a flat-panel detector, facing each other, move in circular orbits around the irradiated object. In order to extract the parameters of the geometry from the data, we use a light needle phantom which is easy to manufacture. A model with ten free parameters (spatial lengths and distortion angles) has been put forth to describe the geometry and the mechanical imperfections of the units being calibrated; a few additional parameters are introduced to account for residual effects (small effects which lie beyond our model). The values of the model parameters are determined from one complete scan of the needle phantom via a robust optimisation scheme. The application of this method to two sets of five counterclockwise (ccw) and five clockwise (cw) scans yielded consistent and reproducible results. A number of differences have been observed be...

  1. Development of a calorimetric system for electron beam dosimetry in radiation processing

    International Nuclear Information System (INIS)

    A calorimetric system for electron beam dosimetry in radiation processing was developed. The system is composed of a graphite core calorimeter, the temperature measuring and electrical calibrating instrumentation, a microcomputer and the software for the system automation. The research aimed at the optimization of the project parameters, the development of advanced methodologies for calibrating the temperature sensor, the determination of the thermal capacity as a function of the temperature, the measurement of the absorbed dose, and the development of the software needed for the system operation. The operating range extends from 0.1 kGy to 30 kGy. The uncertainty in the measurement of the absorbed dose was estimated to be ± 1.8% at the 95% confidence level. Comparative tests of the absorbed dose measurements were made using the IPEN electron accelerator. The results obtained showed an excellent agreement between the absorbed dose determined by the calorimeter and the absorbed dose calculated from the nominal power delivered by the accelerator. (author). 67 refs, 63 figs, 2 tabs

  2. A Study On A Preparation Of Nanogel Using The Electron Beam Radiation Technique For Agricultural Applications

    International Nuclear Information System (INIS)

    Polyvinylpyrrolidone (N-PVP) and carboxymethyl starch (N-CMS) nanogels were studied and prepared by the intramolecular crosslinking technique under the exposure to electron beams at a suitable absorbed dose of 11.6 kGy for a 0.5% PVP solution and at a suitable absorbed dose of 15.6 kGy for a 0.7% CMS solution. The following characteristic properties of N-PVP and N-CMS were determined: intrinsic viscosity, weight average molecular weight, coil size, coil size distribution, stability, etc. In addition, N-CMS and N-PVP systems were also evaluated on their age as exposed to gamma radiation and sunlight. The field test of leaf-spray fertilizer solution based on two following formulations: N-PVP, KNO3 and micro-elements (GEF-K); and N-CMS, kali humate and micro-elements (GEF-Humat) on Chinese cabbages, peanut trees, rice and dragon trees has been carried out. The field trial results are promising for large scale applications of the products in the near future. (author)

  3. Radiation chemistry in alanine irradiated with γ-rays and ion beams

    International Nuclear Information System (INIS)

    In order to extend the application of alanine dosimetry, the behavior of free radicals in solid α-alanine irradiated with γ-rays and with ion beams was studied by electron spin resonance. Stable neutral radicals are produced through the decomposition of originally generated ion radicals in alanine irradiated at 300 K, while at 77 K the ion radicals are stable, and also do not decompose. The rate of the combination reaction of the neutral radicals and of the ion radicals was studied by measuring the saturation behavior of the radical concentration in γ-radiolysis at 300 and at 77 K. The yield of the neutral radicals was compared between 0.5, 1,2 and 3 MeV H+, 0.5, 1, and 3 MeV He+, 175 MeV Ar8+ and 460 MeV Ar13+ ion irradiations. Dependence of the radical yield on the radiation quality is understood more in terms of the rate of the combination reaction between the ion radicals than with that between the neutral radicals, and has to do with high local dose within the ion tracks. (Author)

  4. Radiation chemistry in alanine irradiated with {gamma}-rays and ion beams

    Energy Technology Data Exchange (ETDEWEB)

    Koizumi, Hitoshi; Ichikawa, Tsuneki; Yoshida, Hiroshi [Hokkaido Univ., Sapporo (Japan). Faculty of Engineering

    1997-01-01

    In order to extend the application of alanine dosimetry, the behavior of free radicals in solid {alpha}-alanine irradiated with {gamma}-rays and with ion beams was studied by electron spin resonance. Stable neutral radicals are produced through the decomposition of originally generated ion radicals in alanine irradiated at 300 K, while at 77 K the ion radicals are stable, and also do not decompose. The rate of the combination reaction of the neutral radicals and of the ion radicals was studied by measuring the saturation behavior of the radical concentration in {gamma}-radiolysis at 300 and at 77 K. The yield of the neutral radicals was compared between 0.5, 1,2 and 3 MeV H{sup +}, 0.5, 1, and 3 MeV He{sup +}, 175 MeV Ar{sup 8+} and 460 MeV Ar{sup 13+} ion irradiations. Dependence of the radical yield on the radiation quality is understood more in terms of the rate of the combination reaction between the ion radicals than with that between the neutral radicals, and has to do with high local dose within the ion tracks. (Author).

  5. Applications of pixellated GaAs X-ray detectors in a synchrotron radiation beam

    Energy Technology Data Exchange (ETDEWEB)

    Watt, J. E-mail: j.watt@physics.gla.ac.uk; Bates, R.; Campbell, M.; Mathieson, K.; Mikulec, B.; O' Shea, V.; Passmore, M-S.; Schwarz, C.; Smith, K.M.; Whitehill, C

    2001-03-11

    Hybrid semiconductor pixel detectors are being investigated as imaging devices for radiography and synchrotron radiation beam applications. Based on previous work in the CERN RD19 and the UK IMPACT collaborations, a photon counting GaAs pixel detector (PCD) has been used in an X-ray powder diffraction experiment. The device consists of a 200 {mu}m thick SI-LEC GaAs detector patterned in a 64x64 array of 170 {mu}m pitch square pixels, bump-bonded to readout electronics operating in single photon counting mode. Intensity peaks in the powder diffraction pattern of KNbO{sub 3} have been resolved and compared with results using the standard scintillator, and a PCD predecessor (the {omega}3). The PCD shows improved speed, dynamic range, 2-D information and comparable spatial resolution to the standard scintillator based systems. It also overcomes the severe dead time limitations of the {omega}3 by using a shutter based acquisition mode. A brief demonstration of the possibilities of the system for dental radiography and image processing are given, showing a marked reduction in patient dose and dead time compared with film.

  6. Radiation response of multi-quantum well solar cells: Electron-beam-induced current analysis

    International Nuclear Information System (INIS)

    Solar cells utilizing multi-quantum well (MQW) structures are considered promising candidate materials for space applications. An open question is how well these structures can resist the impact of particle irradiation. The aim of this work is to provide feedback about the radiation response of In0.01Ga0.99As solar cells grown on Ge with MQWs incorporated within the i-region of the device. In particular, the local electronic transport properties of the MQW i-regions of solar cells subjected to electron and proton irradiation were evaluated experimentally using the electron beam induced current (EBIC) technique. The change in carrier collection distribution across the MQW i-region was analyzed using a 2D EBIC diffusion model in conjunction with numerical modeling of the electrical field distribution. Both experimental and simulated findings show carrier removal and type conversion from n- to p-type in MQW i-region at a displacement damage dose as low as ∼6.06–9.88 × 109 MeV/g. This leads to a redistribution of the electric field and significant degradation in charge carrier collection

  7. Development of a CT based radiation treatment planning system for high energy photon beams

    International Nuclear Information System (INIS)

    An external beam radiation treatment planning system based on CT images has been developed. The main functions built in this system are as follows: (1) Three dimensional dose calculations based on the tissue-air ratio (TAR) and off-center axis ratio (OCR) method for rectangular fields and on the scatter-air ratio (SAR) method for irregularly shaped fields, (2) Inhomogeneity corrections by pixel-by-pixel and inhomogeneity region methods utilizing the CT numbers, (3) Display of isodose distributions superimposed on the CT images, (4) Measurement of point-to-point vertical and horizontal distances on the CT images using a light pen, (5) Automatic calculation and drawing of an irradiation field shape from target volumes delineated on the CT images, (6) Dose distribution analysis program such as calculation of statistical values of dose in a target volume, and of integral dose and dose spectrum in any region(s) of interest. Examples of plans and initial verification results are discussed. (author)

  8. Degradation of catechol by ionizing radiation, ozone and the combined process ozone-electron-beam

    International Nuclear Information System (INIS)

    The influence of oxygen on the radiation-induced degradation of catechol (5x10-4 mol dm-3, 55 mg dm-3) in distilled water was studied by gamma-radiolysis in the presence of air (A) and using air saturation (AS) during irradiation. Under AS conditions a complete decomposition of catechol as well as of the trihydroxybenzene products was obtained by a dose of 6 kGy, without air saturation all phenolic compounds were still present at 10 kGy. Using AS, at 12 kGy the total organic carbon (TOC) was reduced by 63%, without air saturation by 17.5%. Detoxification was only obtained in AS solutions. In the presence of the natural matrix of the local tap water no trihydroxybenzene products were formed and for total decomposition of catechol in AS solutions 9 kGy were required. The comparison of the effectiveness of an electron beam (EB), an ozone (O3) and a combined EB/O3 process showed, that by EB/O3 the extent of catechol degradation corresponded to the sum of the decay with EB and with ozone, whereas for the chemical oxygen demand and TOC reduction a synergistic effect was evident

  9. Electron beam radiation damage to organic inclusions in vitreous, cubic, and hexagonal ice

    International Nuclear Information System (INIS)

    Frozen hydrated specimens of various latex spheres were used as well-defined systems for the study of electron beam radiation damage to organic inclusions in vitreous, cubic and hexagonal ice. It was found that radiolysis of organi material is modified by the presence of ice and that radiolysis in vitreous ice is different from that in crystalline ice. The pattern of damage depends also on the nature of the irradiated polymer, e.g., damage to poly(vinylchloride) is quite different from damage to polyacrylates, although in both polymers the main radiolytic process is chain scission. Some polymers such as polyacrylates were found to be much more stable in vitreous ice than in crystalline ice. The experimental results indicate that free radicals formed at the ice-organic matter interface play an important role in the radiolysis process which affects both the ice and embedded organic particles. Ice may play also a physical role in the process by limiting the diffusion of free radicals away from the interface. Although net mass loss is not much affected by ice, massive structural changes including repolymerization take place in its presence. (author)

  10. Phase II Radiation therapy oncology group trial of weekly paclitaxel and conventional external beam radiation therapy for supratentorial glioblastoma multiforme

    International Nuclear Information System (INIS)

    Purpose: Fractionated external beam radiotherapy (EBRT) ± carmustine (BCNU) is the standard of care for patients with glioblastoma multiforme (GBM), but survival results remain poor. Preclinical studies indicate synergy between RT and paclitaxel (TAX) in astrocytoma cell lines. Phase I studies in GBM have demonstrated a maximum tolerated dose for TAX of 225 mg/m2/3 h/week x 6, during EBRT, with no exacerbation of typical RT-induced toxicities. The Radiation Therapy Oncology Group (RTOG) therefore mounted a Phase II study to determine the feasibility and efficacy of conventional EBRT and concurrent weekly TAX at its MTD. Patients and Methods: Sixty-two patients with histologic diagnosis of GBM were enrolled from 8/16/96 through 3/21/97 in a multi-institutional Phase II trial of EBRT and TAX 225 mg/m2/3 h (1-3 h before EBRT), administered the first treatment day of each RT week. Total EBRT dose was 60 Gy (200 cGy/fraction), 5 days per week. A smaller treatment field, to include gross disease plus a margin only, was used after 46 Gy. Results: Sixty-one patients (98%) were evaluable. Median age was 55 years (range, 28-78). Seventy-four percent were ≥50 years. Recursive partitioning analysis (RPA) Classes III, IV, V, VI included 10 (17%), 21 (34%), 25 (41%), and 5 (8%) patients, respectively. Gross total resection was performed in only 16%. There was no Grade 3 or 4 neutropenia or thrombocytopenia. Hypersensitivity reactions precluding further use of TAX occurred in 4 patients. There were 2 instances of late neurotoxicity (4% Grade 3 or 4). Ninety-one percent of patients received treatment per protocol. Seventy-seven percent completed prescribed treatment (6 weeks). Of 35 patients with measurable disease, CR/PR was observed in 23%, MR in 17%, and SD in 43%. Seventeen percent demonstrated progression at first follow-up. Median potential follow-up time is 20 months. Median survival is 9.7 months, with median survivals for RPA classes III, IV, V, and VI of 16.3, 10.2, 9

  11. Axial and transverse acoustic radiation forces on a fluid sphere placed arbitrarily in Bessel beam standing wave tweezers

    Science.gov (United States)

    Mitri, F. G.

    2014-03-01

    The axial and transverse radiation forces on a fluid sphere placed arbitrarily in the acoustical field of Bessel beams of standing waves are evaluated. The three-dimensional components of the time-averaged force are expressed in terms of the beam-shape coefficients of the incident field and the scattering coefficients of the fluid sphere using a partial-wave expansion (PWE) method. Examples are chosen for which the standing wave field is composed of either a zero-order (non-vortex) Bessel beam, or a first-order Bessel vortex beam. It is shown here, that both transverse and axial forces can push or pull the fluid sphere to an equilibrium position depending on the chosen size parameter ka (where k is the wave-number and a the sphere's radius). The corresponding results are of particular importance in biophysical applications for the design of lab-on-chip devices operating with Bessel beams standing wave tweezers. Moreover, potential investigations in acoustic levitation and related applications in particle rotation in a vortex beam may benefit from the results of this study.

  12. Diamonds are not forever - scCVD radiation damage study with high intensity Au beam in HADES

    International Nuclear Information System (INIS)

    Since more than 10 years the HADES group has been involved in the development of diamond detectors based on pcCVD material. These detectors showed very good performance (time resolution below 100 ps sigma) and stable long term operation (over several weeks) at moderate beam (12C) intensities about 105 particles/s/cm2. With the recently finished upgrade of the HADES spectrometer, aimed at preparing for experiments at SIS-100 at the future FAIR facility, the DAQ performance was significantly increased allowing for high intensity beams. The upcoming Au+Au experiment, scheduled for 2012, will utilize an Au beam at intensities between 2-5.106 Au ions/s. Due to the requested very small target diameter, 2.2 mm, the HADES beam focus system has to provide a beam spot below 2 mm2 in the HADES focal point. During a recently conducted five day long test experiment at this beam intensity we have reached a total particle dose close to 2.37.1013 Au ions/cm2 on our diamond start detector which was never archived before. By analysing the surface of the detector and properties like signal amplitude and time resolution we have identified significant radiation damage. In this talk the observed effects are discussed.

  13. Protective role of Carica papaya (Linn.) in electron beam radiation induced hematological and cytogenetic damages in Swiss albino mice

    International Nuclear Information System (INIS)

    Carica papaya (Linn.) is known to possess various biomedical applications. It has remarkable antioxidant properties. The main objective of the study was to evaluate the leaf extracts of Carica papaya (Linn.) on hematologic and cytogenetic changes occurring due to irradiation of mice to sub-lethal doses of Electron Beam Radiation (EBR). Analysis of hematological changes occurring due to irradiation of mice to sub-lethal doses of EBR, and the effects of Carica papaya (Linn.) extract on the same. The Assessment of hematopoietic stress by spleen colony forming unit and spleen body weight index. The analysis of cell proliferation and immunomodulation with response to the effects of Carica papaya (Linn.) extract by estimation of IL-6. The estimation of serum total antioxidants, lipid peroxidation and analyzing the activities of enzymes like SOD, ALP, and AST. Male Swiss albino mice were fed orally with papaya aqueous leaf extract for 15 days. They were irradiated with a whole body dose of 6 Gy Electron Beam radiation. The mice were dissected for liver, kidney, bone marrow, spleen and brain. The hematological studies were done using blood cell count in an automated cell counter. The biochemical estimations like urea, creatinine, SGOT, SGPT, Total Protein, Albumin, Bilirubin were done using the serum and homogenates. The total antioxidant capacity, the antioxidant enzymes were estimated. The Interleukin-6 levels were estimated in serum to assess immune modulation. The results show a decrease in the hematological parameters in radiated animals. The papaya treated groups have shown modulation in the hematological parameters. The extract has also reduced the suppression of the bone marrow induced by radiation. The radiation induced liver damage is also reduced in papaya treated groups. The aqueous extract of Carica papaya (Linn.) has shown protective effects in electron beam radiation induced tissue damages in Swiss Albino mice (author)

  14. Effects of ion beams pretreatment on damage of UV-B radiation on seedlings of winter wheat (Triticum aestivum L.).

    Science.gov (United States)

    Zhao, Shuaipeng; Huang, Qunce; Yang, Pengming; Zhang, Jiajia; Jia, Hongru; Jiao, Zhen

    2012-12-01

    The seeds of winter wheat were pretreated with three different doses of low-energy N(+) beams, and its seedlings were subjected to UV-B irradiation (10.08 kJ m(-2) day(-1)) at three-leaves stage. The growth characteristic of seeds, the oxidative damage to membrane system induced by UV-B radiation, and the alleviating effects of N(+) beams pretreatment to radiation damage were investigated. The results showed that the germination rate and seedling rate, respectively, increased 14.09 ± 1.03 and 13.91 ± 1.21 % compared with control (CK) at the dose of 4.0 × 10(16) ions/cm(2). When seedlings were exposed to UV-B radiation, the pretreatment method under the dose of 4.0 × 10(16) ions/cm(2) made the activity of peroxidase and superoxide dismutase increasing, the content of chlorophyll enhancing, but the content of malondialdehyde reducing significantly compared with that of the single UV-B radiation. Whereas, the activity of catalase irradiated by UV-B improved notably under the pretreatment dose of 8.0 × 10(16) ions/cm(2). In addition, after being irradiated with UV-B, the content of soluble protein and glutathione whose seeds were pretreated by the dose of 6.0 × 10(16) ions/cm(2) were higher than that of the single UV-B radiation. It was suggested that the suitable dose of low-energy ion beams pretreatment to wheat seeds could change its physiological characteristics at seedlings stage to alleviate the damage effects from UV-B radiation. PMID:23054823

  15. Definition of parameters for quality assurance of flattening filter free (FFF) photon beams in radiation therapy

    International Nuclear Information System (INIS)

    Purpose: Flattening filter free (FFF) beams generated by medical linear accelerators have recently started to be used in radiotherapy clinical practice. Such beams present fundamental differences with respect to the standard filter flattened (FF) beams, making the generally used dosimetric parameters and definitions not always viable. The present study will propose possible definitions and suggestions for some dosimetric parameters for use in quality assurance of FFF beams generated by medical linacs in radiotherapy. Methods: The main characteristics of the photon beams have been analyzed using specific data generated by a Varian TrueBeam linac having both FFF and FF beams of 6 and 10 MV energy, respectively. Results: Definitions for dose profile parameters are suggested starting from the renormalization of the FFF with respect to the corresponding FF beam. From this point the flatness concept has been translated into one of “unflatness” and other definitions have been proposed, maintaining a strict parallelism between FFF and FF parameter concepts. Conclusions: Ideas for quality controls used in establishing a quality assurance program when introducing FFF beams into the clinical environment are given here, keeping them similar to those used for standard FF beams. By following the suggestions in this report, the authors foresee that the introduction of FFF beams into a clinical radiotherapy environment will be as safe and well controlled as standard beam modalities using the existing guidelines.

  16. Measurement of electron-beam bunch length and emittance using shot-noise-driven fluctuations in incoherent radiation

    International Nuclear Information System (INIS)

    Longitudinal and transverse phase space information has been obtained from a statistical analysis of fluctuations in the radiation spectrum of an electron bunch. Uncorrelated shot noise fluctuations in longitudinal beam density result in incoherent radiation with a spectrum that consists of spikes, with width inversely proportional to the bunch length. Measurements were performed at λ=620 nm on a 1--5 ps long, 44 MeV bunch propagating through a wiggler. Bunch length and emittance obtained with this single shot technique agree with independent measurements

  17. Metal micro-detector TimePix imaging synchrotron radiation beams at the ESRF Bio-Medical Beamline ID17

    International Nuclear Information System (INIS)

    Characterization studies of the metal micro-detector TimePix measuring dose distribution at the Minibeam Radiation Therapy setup (Bio-Medical Beamline ID17, ESRF) were performed. The results obtained for high intensity synchrotron radiation minibeams illustrate an excellent performance of the TimePix providing in real time 2D image of the dose distribution over many beams in a 14×14 mm2 area. Peak-to-Valley–Dose–Ratios measured by TimePix and gafhromic films agree well.

  18. Metal micro-detector TimePix imaging synchrotron radiation beams at the ESRF Bio-Medical Beamline ID17

    Energy Technology Data Exchange (ETDEWEB)

    Pugatch, V., E-mail: pugatch@kinr.kiev.ua [Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kiev (Ukraine); Campbell, M. [CERN, Geneva (Switzerland); Chaus, A.; Kovalchuk, O. [Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kiev (Ukraine); Llopart, X. [CERN, Geneva (Switzerland); Okhrimenko, O. [Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kiev (Ukraine); Pospisil, S. [Institute of Experimental and Applied Physics, Prague (Czech Republic); Prezado, Y.; Renier, M. [ESRF, Grenoble (France); Tlustos, L. [CERN, Geneva (Switzerland)

    2012-08-01

    Characterization studies of the metal micro-detector TimePix measuring dose distribution at the Minibeam Radiation Therapy setup (Bio-Medical Beamline ID17, ESRF) were performed. The results obtained for high intensity synchrotron radiation minibeams illustrate an excellent performance of the TimePix providing in real time 2D image of the dose distribution over many beams in a 14 Multiplication-Sign 14 mm{sup 2} area. Peak-to-Valley-Dose-Ratios measured by TimePix and gafhromic films agree well.

  19. Performance studies of an optical fiber OSL/RL dosimetry system in pulsed high-intensity radiation beams

    CERN Document Server

    Ravotti, F; Dusseau, Laurent; Mukherjee, Bhaskar; Glaser, Maurice; Ravotti, Federico

    2010-01-01

    The SrS:Ce,Sm phosphor is suitable for operation in harsh radiation environments where real-time dosimetry measurements are needed to survey the Total Ionizing Dose (TID) damage in electronic components. For these applications, the OSL and RL emissions from this phosphor can be exploited by mounting the SrS crystal at the edge of a single, radiation-hard, optical fiber. In this work we present an exhaustive characterization of this real-time OSL/RL probe including stability, repeatability of the measured signals, dosimetry performance and measurements of the temporal behavior of the RI signal in pulsed particle beams. (C) 2009 Elsevier Ltd. All rights reserved.

  20. X-ray diffraction using synchrotron radiation on the G.I.L.D.A. beam line at the E.S.R.F

    Energy Technology Data Exchange (ETDEWEB)

    Balerna, A. [INFN, Laboratori Nazionali di Frascati, Rome (Italy); Meneghini, C. [INFN, Laboratori Nazionali di Frascati, Rome (Italy)]|[INFM, Genoa (Italy); Bordoni, S. [Rome Univ. `Tor Vergata` (Italy). Dip. di Fisica; Mobilio, S. [Rome Univ. III (Italy). Dip. di Fisica `E. Amaldi`

    1996-09-01

    The aim of this lecture is to make a short introduction on Synchrotron radiation, its history and main properties. The main components of a synchrotron radiation beam line will be described. The Italian beam line, General purpose Italian beam line Line for Diffraction and Absorption (G.I.L.D.A.) at the European Synchrotron Radiation Facility (E.S.R.F.) in Grenoble will be used as an example. The G.I.L.D.A. diffractometer will be described in detail reporting also some experimental results.

  1. Calculation And Design Of A New Configuration For Radiation Shielding At Neutron Beam No.3 For Fundamental And Applied Researches

    International Nuclear Information System (INIS)

    The tangential horizontal channel of No. 3 of the Dalat Research Reactor has been opened and used during the 1990s. The utilizations of the thermal neutron beam at this channel were the Neutron Radiography and the Prompt Gamma Neutron Activation Analysis method (PGNAA). At present, the neutron beam used for nuclear structure data researches based on the Summing of Amplitude Coincident Pulses system (SACP). Beside, several related research equipments have been set up and operated for the research purposes. A renovation of the neutron channel, therefore, will play an important role in safe and effective utilizations of the neutron beam in fields of nuclear physic training and researches. A new configuration for radiation shielding has been simulated by MCNP code. The calculated results of dose rates for neutron and gamma at working positions are in range of dose rate limit. (author)

  2. Determination Of Some Specific Parameters In Energy Spectrum Of Electron Beams From The Radiation Therapy Linear Accelerator Siemens PRIMUS

    International Nuclear Information System (INIS)

    Mean energy E0 and maximum probability energy Ep,0 of electron beams on the patient skin are important parameters using in radiotherapy. This report presents the experimental method assessing quality of 12 MeV electron beam from Radiation therapy Linac-SIEMENS Primus at the National Cancer Hospital (K Hospital). Absorbed dose distribution and absorbed curve of a certain field size at the depths in medium have been defined by absorbed measurement technique in water phantom. The determination of Ep,0 and E0 is based on the use of semi- empirical relationships between electron energy and range parameters, which are determined in percentage depth dose curve for electron beam in water phantom. (author)

  3. Analysis of the power system from an electron beam accelerator and the correlation with the theoretical dosimetry for radiation processing

    Energy Technology Data Exchange (ETDEWEB)

    Somessari, Samir Luiz; Somessari, Elizabeth S. Ribeiro; Silveira, Carlos Gaia da; Calvo, Wilson Aparecido Parejo, E-mail: somessar@ipen.br, E-mail: esomessa@ipen.br, E-mail: cgsilvei@ipen.br, E-mail: wapcalvo@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    Dynamitron DC1500/25/04 type electron beam accelerator (EBA), model JOB 188, was manufactured by IBA Industrial (Radiation Dynamics, Inc.) and installed at IPEN/CNEN-SP in 1978. The technical specifications of the EBA are: energy 0.5 to 1.5 MeV; beam current: 0.3 to 25.0 mA; beam scanning: 60 to 120 cm; beam width: 25.4 mm and frequency: 100 Hz. Nowadays, this accelerator has been used for innumerable applications, such as: for sterilization of medical, pharmaceutical and biological products; treatment of industrial and domestic effluents and sludge; preservation and disinfestation of foods and agricultural products; lignocellulosic material irradiation as a pre-treatment to produce ethanol bio-fuel; decontamination of pesticide packing; solid residues remediation; organic compounds removal from wastewater; treatment of effluent from petroleum production units; crosslinking of foams, wires and electric cables; composite and nanocomposite materials and carbon fibers irradiation; irradiated grafting ion-exchange membranes for fuel cells application; natural polymers and multilayer packages irradiation, and biodegradable blends production. The energy of the electron beam is calculated as a function of the current in the accelerator high-voltage divisor, taking into account the thickness and density of the material to be irradiated. This energy is calculated considering the electron through the entire material and the distance from the titanium foil window, so that the absorbed doses at the point of entrance and exit are equivalent on the material. The dose is directly proportional to the beam current and the exposure time of the material under the electron beam and inversely proportional to the scan width. The aim of this paper is to analyze the power system parameters of the EBA Dynamitron DC1500/25/04 accelerator, such as, voltage and root-mean-square (RMS) current in the oscillator system, high voltage generator and waveform, using software developed in the

  4. Analysis of the power system from an electron beam accelerator and the correlation with the theoretical dosimetry for radiation processing

    International Nuclear Information System (INIS)

    Dynamitron DC1500/25/04 type electron beam accelerator (EBA), model JOB 188, was manufactured by IBA Industrial (Radiation Dynamics, Inc.) and installed at IPEN/CNEN-SP in 1978. The technical specifications of the EBA are: energy 0.5 to 1.5 MeV; beam current: 0.3 to 25.0 mA; beam scanning: 60 to 120 cm; beam width: 25.4 mm and frequency: 100 Hz. Nowadays, this accelerator has been used for innumerable applications, such as: for sterilization of medical, pharmaceutical and biological products; treatment of industrial and domestic effluents and sludge; preservation and disinfestation of foods and agricultural products; lignocellulosic material irradiation as a pre-treatment to produce ethanol bio-fuel; decontamination of pesticide packing; solid residues remediation; organic compounds removal from wastewater; treatment of effluent from petroleum production units; crosslinking of foams, wires and electric cables; composite and nanocomposite materials and carbon fibers irradiation; irradiated grafting ion-exchange membranes for fuel cells application; natural polymers and multilayer packages irradiation, and biodegradable blends production. The energy of the electron beam is calculated as a function of the current in the accelerator high-voltage divisor, taking into account the thickness and density of the material to be irradiated. This energy is calculated considering the electron through the entire material and the distance from the titanium foil window, so that the absorbed doses at the point of entrance and exit are equivalent on the material. The dose is directly proportional to the beam current and the exposure time of the material under the electron beam and inversely proportional to the scan width. The aim of this paper is to analyze the power system parameters of the EBA Dynamitron DC1500/25/04 accelerator, such as, voltage and root-mean-square (RMS) current in the oscillator system, high voltage generator and waveform, using software developed in the

  5. New ICRU quantities for the environmental and individual monitoring. Standardization of individual dosemeters by using external beams of photon radiation

    International Nuclear Information System (INIS)

    The quantities introduced by ICRU for the radiological monitoring are commented, specially those implied in individual protection against external photons. A procedure is proposed in order to standardize the individual dosemeters by using the kerma in air references of CIEMAT-JEN. The reference radiation beams are described in connection with ISO standards. Provisional values are selected for the appropriate conversion and correction factors. (Author) 23 refs

  6. Collisional and Radiative Processes in Adiabatic Deceleration, Deflection, and Off-Axis Trapping of a Rydberg Atom Beam

    International Nuclear Information System (INIS)

    A supersonic beam of Rydberg hydrogen atoms has been adiabatically deflected by 90 deg., decelerated to zero velocity in less than 25 μs, and loaded into an electric trap. The deflection has allowed the suppression of collisions with atoms in the trailing part of the gas pulse. The processes leading to trap losses, i.e., fluorescence to the ground state, and transitions and ionization induced by blackbody radiation have been monitored over several milliseconds and quantitatively analyzed.

  7. Study of radiation damage and substrate resistivity effects from beam test of silicon microstrip detectors using LHC readout electronics

    International Nuclear Information System (INIS)

    We present the beam test results of single-sided silicon microstrip detectors, with different substrate resistivities. The effects of radiation damage are studied for a detector irradiated to a fluence of 2.4x1014 n/cm2. The detectors are read out with the APV6 chip, which is compatible with the 40 MHz LHC clock. The performance of different detectors and readout modes are studied in terms of signal-to-noise ratio and efficiency

  8. Verification of intensity modulated radiation therapy beams using a tissue equivalent plastic scintillator dosimetry system

    Science.gov (United States)

    Petric, Martin Peter

    This thesis describes the development and implementation of a novel method for the dosimetric verification of intensity modulated radiation therapy (IMRT) fields with several advantages over current techniques. Through the use of a tissue equivalent plastic scintillator sheet viewed by a charge-coupled device (CCD) camera, this method provides a truly tissue equivalent dosimetry system capable of efficiently and accurately performing field-by-field verification of IMRT plans. This work was motivated by an initial study comparing two IMRT treatment planning systems. The clinical functionality of BrainLAB's BrainSCAN and Varian's Helios IMRT treatment planning systems were compared in terms of implementation and commissioning, dose optimization, and plan assessment. Implementation and commissioning revealed differences in the beam data required to characterize the beam prior to use with the BrainSCAN system requiring higher resolution data compared to Helios. This difference was found to impact on the ability of the systems to accurately calculate dose for highly modulated fields, with BrainSCAN being more successful than Helios. The dose optimization and plan assessment comparisons revealed that while both systems use considerably different optimization algorithms and user-control interfaces, they are both capable of producing substantially equivalent dose plans. The extensive use of dosimetric verification techniques in the IMRT treatment planning comparison study motivated the development and implementation of a novel IMRT dosimetric verification system. The system consists of a water-filled phantom with a tissue equivalent plastic scintillator sheet built into the top surface. Scintillation light is reflected by a plastic mirror within the phantom towards a viewing window where it is captured using a CCD camera. Optical photon spread is removed using a micro-louvre optical collimator and by deconvolving a glare kernel from the raw images. Characterization of this

  9. Clinical Implementation of Intrafraction Cone Beam Computed Tomography Imaging During Lung Tumor Stereotactic Ablative Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: To develop and clinically evaluate a volumetric imaging technique for assessing intrafraction geometric and dosimetric accuracy of stereotactic ablative radiation therapy (SABR). Methods and Materials: Twenty patients received SABR for lung tumors using volumetric modulated arc therapy (VMAT). At the beginning of each fraction, pretreatment cone beam computed tomography (CBCT) was used to align the soft-tissue tumor position with that in the planning CT. Concurrent with dose delivery, we acquired fluoroscopic radiograph projections during VMAT using the Varian on-board imaging system. Those kilovolt projections acquired during millivolt beam-on were automatically extracted, and intrafraction CBCT images were reconstructed using the filtered backprojection technique. We determined the time-averaged target shift during VMAT by calculating the center of mass of the tumor target in the intrafraction CBCT relative to the planning CT. To estimate the dosimetric impact of the target shift during treatment, we recalculated the dose to the GTV after shifting the entire patient anatomy according to the time-averaged target shift determined earlier. Results: The mean target shift from intrafraction CBCT to planning CT was 1.6, 1.0, and 1.5 mm; the 95th percentile shift was 5.2, 3.1, 3.6 mm; and the maximum shift was 5.7, 3.6, and 4.9 mm along the anterior-posterior, left-right, and superior-inferior directions. Thus, the time-averaged intrafraction gross tumor volume (GTV) position was always within the planning target volume. We observed some degree of target blurring in the intrafraction CBCT, indicating imperfect breath-hold reproducibility or residual motion of the GTV during treatment. By our estimated dose recalculation, the GTV was consistently covered by the prescription dose (PD), that is, V100% above 0.97 for all patients, and minimum dose to GTV >100% PD for 18 patients and >95% PD for all patients. Conclusions: Intrafraction CBCT during VMAT can provide

  10. Clinical Implementation of Intrafraction Cone Beam Computed Tomography Imaging During Lung Tumor Stereotactic Ablative Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Li, Ruijiang; Han, Bin; Meng, Bowen [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California (United States); Maxim, Peter G.; Xing, Lei; Koong, Albert C. [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California (United States); Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California (United States); Diehn, Maximilian, E-mail: Diehn@Stanford.edu [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California (United States); Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California (United States); Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California (United States); Loo, Billy W., E-mail: BWLoo@Stanford.edu [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California (United States); Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California (United States)

    2013-12-01

    Purpose: To develop and clinically evaluate a volumetric imaging technique for assessing intrafraction geometric and dosimetric accuracy of stereotactic ablative radiation therapy (SABR). Methods and Materials: Twenty patients received SABR for lung tumors using volumetric modulated arc therapy (VMAT). At the beginning of each fraction, pretreatment cone beam computed tomography (CBCT) was used to align the soft-tissue tumor position with that in the planning CT. Concurrent with dose delivery, we acquired fluoroscopic radiograph projections during VMAT using the Varian on-board imaging system. Those kilovolt projections acquired during millivolt beam-on were automatically extracted, and intrafraction CBCT images were reconstructed using the filtered backprojection technique. We determined the time-averaged target shift during VMAT by calculating the center of mass of the tumor target in the intrafraction CBCT relative to the planning CT. To estimate the dosimetric impact of the target shift during treatment, we recalculated the dose to the GTV after shifting the entire patient anatomy according to the time-averaged target shift determined earlier. Results: The mean target shift from intrafraction CBCT to planning CT was 1.6, 1.0, and 1.5 mm; the 95th percentile shift was 5.2, 3.1, 3.6 mm; and the maximum shift was 5.7, 3.6, and 4.9 mm along the anterior-posterior, left-right, and superior-inferior directions. Thus, the time-averaged intrafraction gross tumor volume (GTV) position was always within the planning target volume. We observed some degree of target blurring in the intrafraction CBCT, indicating imperfect breath-hold reproducibility or residual motion of the GTV during treatment. By our estimated dose recalculation, the GTV was consistently covered by the prescription dose (PD), that is, V100% above 0.97 for all patients, and minimum dose to GTV >100% PD for 18 patients and >95% PD for all patients. Conclusions: Intrafraction CBCT during VMAT can provide

  11. Polymer gels impregnated with gold nanoparticles implemented for measurements of radiation dose enhancement in synchrotron and conventional radiotherapy type beams

    International Nuclear Information System (INIS)

    Normoxic type polyacrylamide gel (nPAG) dosimeters are established for dose quantification in three-dimensions for radiotherapy and hence represent an adequate dosimeter for quantification of the dose variation due to the existence of the gold nanoparticles (AuNPs) in the target during irradiation. This work compared the degree of polymerisation in gel doped with nanoparticles (nPAG–AuNP) with control gel samples when irradiated by various sources. Samples were irradiated with a synchrotron radiation source of mean energy 125 keV, 80 kV X-ray beams from superficial therapy machine (SXRT), 6 MV X-rays and 6 MeV electron beams from linear accelerator. Analysis of the dose–response relation was used to determine a dose enhancement factor (DEF) of 1.76 ± 0.34 and 1.64 ± 0.44 obtained for samples irradiated with kilovoltage X-rays energy from synchrotron source and SXRT respectively. Similarly, including AuNPs in gel results in a DEF of approximately 1.37 ± 0.35 when irradiated by an electron beam and 1.14 ± 0.28 for high energy X-ray beams. The results demonstrate the use of AuNPs embedded in polymer gels for measuring the enhancement of radiation caused by metallic nanoparticles.

  12. Studies on high γ-aminobutyric acid-producing monascus purpureus which breeding with heavy ion beam radiation

    International Nuclear Information System (INIS)

    γ-Aminobutyric Acid (GABA) is a kind of nonprotein amino acid, which is reported to antihypertension, tranquilization, improve liver function, prevent obesity and avoid senile dementia, etc., and is an important effective component in health products. In this study, Monascus Purpureus spores were radiated with 96 MeV/u, LET=28.12 keV/μm 12C6+ ion beams. Doses were set as 20, 50 and 80 Gy, respectively. The experiments were run as follows: preparation of monospore suspension → irradiated with heavy ion beam → diluted and spread on dish → screening and stored in inclined plane → shaking culture → GABA extraction → GABA concentration determined by paper chromatography. One stable high productive strain HQ06 was obtained in this study. The content of GABA in HQ06 was 2.50±0.04 mg/ml, 3.7±1.7% higher than that in control (which was 2.41±0.03 mg/ml). Results showed that it is feasible for breeding high GABA producing strains with heavy ion beam radiation, and the heavy ion beam is a kind of effective mutation source. Further studies should be done for breeding much higher productive strains to satisfy the demands of industry. (authors)

  13. Sugarcane bagasse ash reinforced HDPE composites: effects of electron-beam radiation crosslinking on tensile and morphological properties

    Energy Technology Data Exchange (ETDEWEB)

    Teixeira, Jaciele G.; Gomes, Michelle G.; Oliveira, Rene R.; Silva, Valquiria A.; Sartori, Mariana M.; Ortiz, Angel V.; Moura, Esperidiana A.B., E-mail: jacielegteixeira@yahoo.com [Instituto de Pesquisas Energeticas e Nucleares (IPEN-CNEN/SP), Sao Paulo, SP (Brazil)

    2013-07-01

    Environmental issues have led to the development of polymeric materials reinforced with fibers originated from renewable agricultural sources such as pineapple leaf, sisal, jute, piassava, coir, and sugarcane bagasse. Although sugarcane bagasse fiber residues has been extensively studied and used as a source of reinforcement of polymers, the major portion of these residues is currently burnt for energy supply in the sugar and alcohol industries and as a result of its burning, tons of ashes are produced. Due to the inorganic composition, ashes can be used as reinforcement in polymeric materials. This study presents the preparation and characterization of a composite based on HDPE matrix and sugarcane bagasse ashes as reinforcement cross-linked by electron-beam radiation. The HDPE /Ash composite (95:5 wt %) was obtained by using a twin-screw extruder machine followed by injection molding. After extrusion and injection molding process, the composites were subjected to electron-beam radiation, at radiation doses of 150 kGy and 250 kGy using a Dynamitron electron beam accelerator, at room temperature in the presence of air. The irradiated and non-irradiated composite specimens were characterization by tensile and MFI tests, scanning electron microscopy (SEM), X-ray diffraction (XRD) and sol-gel analysis. In addition, ash from bagasse fiber was characterized by WDXRF. (author)

  14. Application of electron beam radiation for peat sterilization and suppression of microbe contaminants

    International Nuclear Information System (INIS)

    Inoculation of root nodule bacteria into legume seeds such as soybean [Glycine max. (L.)], common bean (Phaseolus vulgaris L.) and forage pasture has been effective and convenient as this simple procedure may introduce effective strains of Bradyrhizobium/Rhizobium into agricultural soils without a past history of successful cropping systems with the legume hosts. Peat-based substrates previously sterilized have been used for decades as bacteria carrier, protecting them from the prevailing harsh conditions in tropical soils and ensuring their survival with nutrient and protection against the soil antagonists. The Brazilian Government requires that all peat-based substrates must be gamma-sterilized from a cobalt-60 (60Co) source, prior the introduction of the root nodule bacteria into the package. The recommendation is for a dose up to 50 kGy for an effective suppression of pathogens and saprophytes, in order to avoid competition among the substrate microbiota. Recently, the use of the electron beam (EB) accelerator has shown to be a new alternative for peat pre-sterilization, as this technique may promote reactive free-radicals which are efficient to suppress microbial contaminants. This fast technology is considered more environment and ecology friendly-sound than gamma radiation (γ). The disadvantage of not reaching higher depth than gamma rays from 60Co must be considered, and attempts of optimizing the technique are crucial. This study compared both methods by using increasing rates of radiation by 60Co by the EB method - O, 10, 20, 30, 40 e 50 kGy in a commercial peat used for inoculants. Experimental data from days 7, 14, 21 and 28 days (growth period) and 150, 180 and 210 days (storage period) indicated high numbers of the strain Rhizobium tropici CM-01, labelled with gusA+ (Study 1) and celB+ (Study 2) from both eat-sterilizing techniques, reaching values above the minimum of 1x108 cells g-1 peat. At high rates, above 40 kGy, and after long incubation

  15. Kinetics of serum prostate-specific antigen after external beam radiation for clinically localized prostate cancer

    International Nuclear Information System (INIS)

    Background and purpose: To determine the kinetics of serum prostate-specific antigen (PSA) after radiation therapy of localized prostate cancer and to evaluate whether such kinetics provide prognostic information. Materials and methods: Eight hundred forty-one men with serial PSA determinations who underwent external beam radiation without androgen ablation were analyzed to determine postradiation PSA kinetic parameters (half-life and doubling time) and to correlate these parameters with disease outcome. Non-linear regression techniques were used to determine half-lives and doubling times. Results: The postradiation serum PSA data fitted well to first order kinetic models. The median PSA half-life was 1.6 months (range 0.5-9.2 months). There was no correlation between half-life and T-stage or Gleason grade. A significant but quantitatively weak correlation was present between the pretreatment PSA level and half-life; lower pretreatment levels were associated with longer half-lives. Half-life did not correlate with disease outcome whether the endpoint was local recurrence, distant metastasis or rising PSA. In 263 men with a rising postradiation PSA profile the median PSA doubling time was 12.2 months (range 0.8-80.2 months). Faster doubling times were significantly associated with higher T-stage, higher Gleason grade and higher pretreatment PSA levels. Thus, patients with initially adverse disease developed faster rising PSA values after treatment than patients with less adverse disease. The most striking correlation was between rapid doubling time and the likelihood of metastatic relapse. Patients who developed metastases had a median PSA doubling time of 4.2 months compared to a median doubling time of 11.7 months in patients who developed local recurrence. Overall, patients with a PSA doubling time of less than 8 months had a 7-year actuarial metastatic rate of 54%, while patients with a PSA doubling time exceeding 8 months had only a 7% metastatic rate

  16. Particle beam radiation therapy using carbon ions and protons for oligometastatic lung tumors

    International Nuclear Information System (INIS)

    A study was undertaken to analyze the efficacy and feasibility of particle beam radiation therapy (PBRT) using carbon ions and protons for the treatment of patients with oligometastatic lung tumors. A total of 47 patients with 59 lesions who underwent PBRT for oligometastatic lung tumors between 2003 and 2011 were included in this study. Patient median age was 66 (range, 39–84) years. The primary tumor site was the colorectum in 11 patients (23.4%), lung in 10 patients (21.3%) and a variety of other sites in 26 patients (55.3%). Thirty-one patients (66%) received chemotherapy prior to PBRT. Thirty-three lesions were treated with 320-MeV carbon ions and 26 were treated with 150- or 210-Mev protons in 1–4 portals. A median total dose of 60 (range, 52.8–70.2) GyE was delivered at the isocenter in 8 (range, 4–26) fractions. The median follow-up time was 17 months. The local control, overall survival and progression-free survival rates at 2 years were 79%, 54 and 27% respectively. PBRT-related toxicities were observed; six patients (13%) had grade 2 toxicity (including grade 2 radiation pneumonitis in 2) and six patients (13%) had grade 3 toxicity. Univariate analysis indicated that patients treated with a biologically equivalent dose of 10 (BED10) <110 GyE10, had a significantly higher local recurrence rate. Local control rates were relatively lower in the subsets of patients with the colorectum as the primary tumor site. No local progression was observed in metastases from colorectal cancer irradiated with a BED10 ≥ 110 GyE10. There was no difference in treatment results between proton and carbon ion therapy. PRBT is well tolerated and effective in the treatment of oligometastatic lung tumors. To further improve local control, high-dose PBRT with a BED10 ≥ 110 GyE10 may be promising. Further investigation of PBRT for lung oligometastases is warranted

  17. The results of radiotherapy for T1 glottic cancers; influence of radiation beam energy

    International Nuclear Information System (INIS)

    Purpose; To report our results of radiotherapy for T1 glottic cancers and to analyze the influence of various parameters. Materials and Methods; Reviewed were the outcome of 57 patients with T1 glottic cancers who received definitive radiotherapy between 1985 and 1993. Of 57 patients, 46 had T1a lesions and 11 T1b. Of 57 lesions, 29 were well differentiated carcinoma, 12 moderately, one poorly and 15 unknown. Seven patients were treated with cobalt-60 unit, 26 with 3-MV linear accelerator, 7 with 6-MV and 17 with 10-MV. Of 17 patients treated with 10-MV, 4 also received part of their treatment with a cobalt-60 unit. Right and left lateral parallel opposed fields was used with all patients. The average field size was 30cm2, with typical field sizes ranging from 5x5 cm to 6x6 cm. Doses reported in this study refer to the central absorbed dose calculated at the central axis. The total radiation doses was 6000 cGy for 49 patients (86%) and the mean total radiation doses was 6100 cGy (range, 5600-7000 cGy). A daily fraction dose was 200 cGy for all patients. All courses of radiotherapy were delivered by using once-a-day fractionation 5 days per week without interruption. Chemotherapy was concurrently used with radiotherapy for 32 patients. Median follow-up was 53 months (range, 3-102 months). The local control and survival curves were adjusted and expressed by Kaplan-Meier method and comparison of the curves were calculated using the log-rank test. Results; Of 54 patients, 13 (24%) had local recurrence. Various parameters including substage; histologic grade; treatment machine; use of chemotherapy were analyzed. The only factor that influenced local control was treatment machine. The local control rate at five years was 93% for cases treated with cobalt-60 unit or a 3-MV linear accelerator and 53% for cases treated with a 6- or 10-MV linear accelerator. The local control rate for cases treated with cobalt-60 unit or a 3-MV linear accelerator was significantly better (p

  18. Structural stability of PAN fiber under high electron beam radiation doses

    International Nuclear Information System (INIS)

    Fiber-reinforced composite are an important class of engineering material. A relevant task of composite technology in order to produce materials for structures of high mechanical performance is to obtain the best carbon fiber. One of the main ways to produce carbon fibers of high Young's modulus and tensile strength is to use as starting material polyacrylonitrile (PAN) fibers which after a rigorous and carefully thermal process become carbon fibers. Since some chemical modifications produced in the thermal treatment can be induced by ionizing radiation, the aim of this paper is to evaluate the effect of high electron beam (EB) doses on a commercial PAN fiber in order to evaluate the use of this technology as an alternative treatment to improve the properties and characteristics of the produced carbon fiber. The doses applied were: 0.2, 0.4, 0.6, 0.8, 1.0 and 1.2 MGy. The irradiation effects induced on the PAN fiber were evaluated by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and thermogravimetry (TG). FTIR obtained data have shown that the main functional groups remain practically unchanged in the non-irradiated and irradiated samples. The single DSC exothermic peak obtained for non-irradiated sample, becomes a double peak after the irradiation, presenting lower initial and higher final temperatures for exothermic DSC curves. The enthalpy involved in the chemical reaction decreases for irradiated samples as compared with the non-irradiated PAN fiber. TG data have shown that irradiated samples start a decomposition process at lower temperatures compared to the non-irradiated sample. (author)

  19. Results of a 5-Week Schedule of Modern Total Skin Electron Beam Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Morris, Stephen Lloyd, E-mail: stephen.morris@gstt.nhs.uk [St Johns Institute of Dermatology, Guys and St Thomas Hospital, London (United Kingdom); McGovern, Mark; Bayne, Sally; Wain, Mary; Child, Fiona; Whittaker, Sean [St Johns Institute of Dermatology, Guys and St Thomas Hospital, London (United Kingdom)

    2013-08-01

    Purpose: To report the outcomes of a 5-week schedule of total skin electron beam radiation therapy (TSEB) for mycosis fungoides (MF). Methods: Over 5 years, 41 patients with confirmed MF were treated with a modern TSEB technique delivering 30 Gy in 20 fractions over 5 weeks to the whole skin surface. Data were collected prospectively and entered into the skin tumor unit research database. Skin modified skin weighted assessment tool score data were collected to determine response, duration of response, survival, and toxicity. The outcomes were analyzed according to the patient's stage before TSEB, prognostic factors, and adjuvant treatments. Results: Seventeen patients were stage 1B, 19 were stage IIB, 3 were stage III, and 2 were stage IV. The overall response rate was 95%, with a complete response rate of 51%. Seventy-six percent of patients had relapsed at median follow-up of 18 months. The median time to relapse was 12 months, to systemic therapy was 15 months, and to modified skin weighted assessment tool progression above baseline was 44 months. The complete response rate was 59% in stage IB and 47% in stage IIB patients. The median time to skin relapse was longer in stage IB compared with stage IIB, 18 months versus 9 months. The median time to systemic therapy was longer in stage IB compared with stage IIB, >56 months versus 8 months. The median overall survival was 35 months: >56 months for stage IB, 25 months for stage IIB, 46 months for stage III, and 23.5 months for stage IV. Fifteen patients received adjuvant psoralen + ultraviolet A treatment with no difference seen in the time to relapse. Conclusions: This 5-week schedule of TSEB for MF has a high response rate with comparable duration of response to other regimens. Future studies are needed to find adjuvant and combination treatments to improve the duration of response.

  20. Cone-Beam Computed Tomographic Image Guidance for Lung Cancer Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: To determine the geometric accuracy of lung cancer radiotherapy using daily volumetric, cone-beam CT (CBCT) image guidance and online couch position adjustment. Methods and Materials: Initial setup accuracy using localization CBCT was analyzed in three lung cancer patient cohorts. The first (n = 19) involved patients with early-stage non-small-cell lung cancer (NSCLC) treated using stereotactic body radiotherapy (SBRT). The second (n = 48) and third groups (n = 20) involved patients with locally advanced NSCLC adjusted with manual and remote-controlled couch adjustment, respectively. For each group, the couch position was adjusted when positional discrepancies exceeded ±3 mm in any direction, with the remote-controlled couch correcting all three directions simultaneously. Adjustment accuracy was verified with a second CBCT. Population-based setup margins were derived from systematic (Σ) and random (σ) positional errors for each group. Results: Localization imaging demonstrates that 3D positioning errors exceeding 5 mm occur in 54.5% of all delivered fractions. CBCT reduces these errors; post-correction Σ and σ ranged from 1.2 to 1.9 mm for Group 1, with 82% of all fractions within ±3 mm. For Group 2, Σ and σ ranged between 0.8 and 1.8 mm, with 76% of all treatment fractions within ±3 mm. For Group 3, the remote-controlled couch raised this to 84%, and Σ and σ were reduced to 0.4 to 1.7 mm. For each group, the postcorrection setup margins were 4 to 6 mm, 3 to 4 mm, and 2 to 3 mm, respectively. Conclusions: Using IGRT, high geometric accuracy is achievable for NSCLC patients, potentially leading to reduced PTV margins, improved outcomes and empowering adaptive radiation therapy for lung cancer

  1. Experimental assessment of gold nanoparticle-mediated dose enhancement in radiation therapy beams using electron spin resonance dosimetry

    International Nuclear Information System (INIS)

    In this work, we aim to experimentally assess increments of dose due to nanoparticle-radiation interactions via electron spin resonance (ESR) dosimetry performed with a biological-equivalent sensitive material.We employed 2-Methyl-Alanine (2MA) in powder form to compose the radiation sensitive medium embedding gold nanoparticles (AuNPs) 5 nm in diameter. Dosimeters manufactured with 0.1% w/w of AuNPs or no nanoparticles were irradiated with clinically utilized 250 kVp orthovoltage or 6 MV linac x-rays in dosimetric conditions. Amplitude peak-to-peak (App) at the central ESR spectral line was used for dosimetry. Dose-response curves were obtained for samples with or without nanoparticles and each energy beam. Dose increments due to nanoparticles were analyzed in terms of absolute dose enhancements (DEs), calculated as App ratios for each dose/beam condition, or relative dose enhancement factors (DEFs) calculated as the slopes of the dose-response curves.Dose enhancements were observed to present an amplified behavior for small doses (between 0.1–0.5 Gy), with this effect being more prominent with the kV beam. For doses between 0.5–5 Gy, dose-independent trends were observed for both beams, stable around (2.1   ±   0.7) and (1.3   ±   0.4) for kV and MV beams, respectively. We found DEFs of (1.62   ±   0.04) or (1.27   ±   0.03) for the same beams. Additionally, we measured no interference between AuNPs and the ESR apparatus, including the excitation microwaves, the magnetic fields and the paramagnetic radicals.2MA was demonstrated to be a feasible paramagnetic radiation-sensitive material for dosimetry in the presence of AuNPs, and ESR dosimetry a powerful experimental method for further verifications of increments in nanoparticle-mediated doses of biological interest. Ultimately, gold nanoparticles can cause significant and detectable dose enhancements in biological-like samples irradiated at both

  2. TH-C-17A-05: Cherenkov Excited Phosphorescence Oxygen (CEPhOx) Imaging During Multi-Beam Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: Cherenkov radiation is created during external beam radiation therapy that can excite phosphorescence in tissue from oxygen-sensitive, bio-compatible probes. Utilizing the known spatial information of the treatment plan with directed multiple beam angles, Cherenkov Excited Phosphorescence Oxygen (CEPhOx) imaging was realized from the reconstructions of Cherenkov excited phosphorescence lifetime. Methods: Platinum(II)-G4 (PtG4) was used as the oxygen-sensitive phosphorescent probe and added to a oxygenated cylindrical liquid phantom with a oxygenated/deoxygenated cylindrical anomaly. Cherenkov excited phosphorescence was imaged using a time-gated ICCD camera temporallysynchronized to the LINAC pulse output. Lifetime reconstruction was carried out in NIRFAST software. Multiple angles of the incident radiation beam was combined with the location of the prescribed treatment volume (PTV) to improve the tomographic recovery as a function of location. The tissue partial pressure of oxygen (pO2) in the background and PTV was calculated based on the recovered lifetime distribution and Stern-Volmer equation. Additionally a simulation study was performed to examine the accuracy of this technique in the setting of a human brain tumor. Results: Region-based pO2 values in the oxygenated background and oxygenated/deoxygenated PTV were correctly recovered, with the deoxygenated anomaly (15.4 mmHg) easily distinguished from the oxygenated background (143 mmHg). The data acquisition time could be achieved within the normal irradiation time for a human fractionated plan. The simulations indicated that CEPhOx would be a sufficient to sample tumor pO2 sensing from tumors which are larger than 2cm in diameter or within 23mm depth from the surface. Conclusion: CEPhOx could be a novel imaging tool for pO2 assessment during external radiation beam therapy. It is minimally invasive and should work within the established treatment plan of radiation therapy with multiple beams in

  3. TH-C-17A-05: Cherenkov Excited Phosphorescence Oxygen (CEPhOx) Imaging During Multi-Beam Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, R; Pogue, B [Dartmouth College, Hanover, NH (United States); Holt, R [Dartmouth College, Hanover, NH - New Hampshire (United States); Esipova, T; Vinogradov, S [University of Pennsylvania, Philadelphia, PA (United States); Gladstone, D [Dartmouth-Hitchcock Medical Center, Hanover, City of Lebanon (Lebanon)

    2014-06-15

    Purpose: Cherenkov radiation is created during external beam radiation therapy that can excite phosphorescence in tissue from oxygen-sensitive, bio-compatible probes. Utilizing the known spatial information of the treatment plan with directed multiple beam angles, Cherenkov Excited Phosphorescence Oxygen (CEPhOx) imaging was realized from the reconstructions of Cherenkov excited phosphorescence lifetime. Methods: Platinum(II)-G4 (PtG4) was used as the oxygen-sensitive phosphorescent probe and added to a oxygenated cylindrical liquid phantom with a oxygenated/deoxygenated cylindrical anomaly. Cherenkov excited phosphorescence was imaged using a time-gated ICCD camera temporallysynchronized to the LINAC pulse output. Lifetime reconstruction was carried out in NIRFAST software. Multiple angles of the incident radiation beam was combined with the location of the prescribed treatment volume (PTV) to improve the tomographic recovery as a function of location. The tissue partial pressure of oxygen (pO2) in the background and PTV was calculated based on the recovered lifetime distribution and Stern-Volmer equation. Additionally a simulation study was performed to examine the accuracy of this technique in the setting of a human brain tumor. Results: Region-based pO2 values in the oxygenated background and oxygenated/deoxygenated PTV were correctly recovered, with the deoxygenated anomaly (15.4 mmHg) easily distinguished from the oxygenated background (143 mmHg). The data acquisition time could be achieved within the normal irradiation time for a human fractionated plan. The simulations indicated that CEPhOx would be a sufficient to sample tumor pO2 sensing from tumors which are larger than 2cm in diameter or within 23mm depth from the surface. Conclusion: CEPhOx could be a novel imaging tool for pO2 assessment during external radiation beam therapy. It is minimally invasive and should work within the established treatment plan of radiation therapy with multiple beams in

  4. Radiosensitivity and Induction of Apoptosis by High LET Carbon Ion Beam and Low LET Gamma Radiation: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Atanu Ghorai

    2014-01-01

    Full Text Available Cancer treatment with high LET heavy ion beam, especially, carbon ion beam (12C, is becoming very popular over conventional radiotherapy like low LET gamma or X-ray. Combination of Poly(ADP-ribose polymerase (PARP inhibitor with xenotoxic drugs or conventional radiation (gamma or X-ray is the newer approach for cancer therapy. The aim of our study was to compare the radiosensitivity and induction of apoptosis by high LET 12C and low LET gamma radiation in HeLa and PARP-1 knocked down cells. We did comet assay to detect DNA breaks, clonogenic survival assay, and cell cycle analysis to measure recovery after DNA damage. We measured apoptotic parameters like nuclear fragmentation and caspase-3 activation. DNA damage, cell killing, and induction of apoptosis were significantly higher for 12C than gamma radiation in HeLa. Cell killing and apoptosis were further elevated upon knocking down of PARP-1. Both 12C and gamma induced G2/M arrest although the 12C had greater effect. Unlike the gamma, 12C irradiation affects DNA replication as detected by S-phase delay in cell cycle analysis. So, we conclude that high LET 12C has greater potential over low LET gamma radiation in killing cells and radiosensitization upon PARP-1 inhibition was several folds greater for 12C than gamma.

  5. Evaluation of the sealing properties and TMA study of multilayer PA/PE film treated with e-beam radiation

    International Nuclear Information System (INIS)

    Multilayer films are widely used in the food industry as thermoforming as well as non thermoforming vacuum packaging. In this study a PA6/LDPE multilayer film underwent E-beam radiation and its sealing properties were evaluated over 3 years after the film was irradiated. Packaging materials have been widely processed by ionizing radiation in order to improve their chemical and physical properties and also for sterilization purposes. Basically, flexible packaging manufacturers apply specific radiation doses to promote cross-linking and scission of the polymeric chains and thus obtain alterations in certain properties. While enhancing a specific property, significant losses may result in others. We examined the effects of E-beam radiation on the sealing properties of the multilayer film irradiated with doses up to 127 kGy. Results showed that as doses go up, the sealing strength goes down. The TMA study shows that the softening/melting temperatures of the LDPE layer (sealing layer) varies according to the irradiation doses and helps explain the results of the sealing strength tests. (author)

  6. E-beam sustained plasma as a medium for the amplification of electromagnetic radiation in the subterahertz frequency band

    International Nuclear Information System (INIS)

    It is demonstrated that low-temperature weakly-ionized nonequilibrium plasma created by a high-energy electron beam in gases (gas mixtures) with the Ramsauer minimum in a transport cross section and the effective attachment of slow electrons can be used as a medium for the amplification of electromagnetic radiation in the subterahertz frequency band. An analysis of the electron energy distribution function (EEDF) in a Xe : F2 mixture is performed. An energy interval with a growing EEDF is found to exist in such a mixture. Such an interval provides the existence of the population inversion of the electron spectrum in the continuum and is responsible for the positive value of a gain factor for microwave radiation. A gain factor depending on amplified radiation frequency and plasma parameters is analysed. (paper)

  7. A Novel Diagnostics of Ultrashort Electron Bunches Based on Detection of Coherent Radiation from Bunched Electron Beam in an Undulator

    CERN Document Server

    Saldin, Evgeny L; Yurkov, Mikhail V

    2004-01-01

    We propose a new method for measurements of the longitudinal profile of 100 femtosecond electron bunches for X-ray Free Electron Lasers (XFELs). The method is based on detection of coherent undulator radiation produced by modulated electron beam. Seed optical quantum laser is used to produce exact optical replica of ultrashort electron bunches. The replica is generated in apparatus which consists of an input undulator (energy modulator), and output undulator (radiator) separated by a dispersion section. The radiation in the output undulator is excited by the electron bunch modulated at the optical wavelength and rapidly reaches a hundred-MW-level power. We then use the now-standard method of ultrashort laser pulse-shape measurement, a tandem combination of autocorrelator and spectrum (FROG -- frequency resolved optical gating) providing real-time single-shot measurements of the electron bunch structure. The big advantage of proposed technique is that it can be used to determine the slice energy spread and emi...

  8. Effect of ocular implants of different materials on the dosimetry of external beam radiation therapy

    International Nuclear Information System (INIS)

    Purpose: To study the attenuation and scattering effects of ocular implants, made from different materials, on the dose distributions of a 6 MV photon beam, and 6, 9, and 12 MeV electron beams used in orbital radiotherapy. Methods and Materials: Central axis depth-dose measurements were performed in a polystyrene phantom with embedded spherical ocular implants using film dosimetry of a 6 MV photon beam and electron beams of 6, 9, and 12 MeV energy. The isodose distributions were also calculated by a computerized treatment planning system using computerized tomography (CT) scans of a polystyrene phantom that had silicone, acrylic, and hydroxyapatite ocular implants placed into it. Results: Electron beam dose distributions display distortions both on the measured and calculated data. This effect is most accentuated for the hydroxyapatite implants, for which the transmissions through ocular implants are on the order of 93% for the 6 MV photon beam, and range from 60% for 6 MeV electrons to 90% for 12 MeV electrons. Conclusion: We studied the effect of ocular implants of various materials, embedded in a polystyrene phantom, on the dose distributions of a 6 MV photon beam, and 6, 9, and 12 MeV electron beams. Our investigations show that while 6 MV photons experience only a few percent attenuation, lower energy electron beam with 60% transmission is not a suitable choice of treating tumors behind the ocular implants

  9. A new ultra radiation hard cryogenic silicon tracker for heavy ion beams

    Energy Technology Data Exchange (ETDEWEB)

    Casagrande, L. E-mail: luca.casagrande@cern.ch; Abreu, M.C.; Borer, K.; De Falco, A.; Dezillie, B.; Granata, V.; Heijne, E.; Hess, M.; Li, Z.; Lourenco, C.; Neves, A.; Niinikoski, T.O.; Palmieri, V.G.; Pes, B.; Ramalhete, P.; Rato Mendes, P.; Rosinsky, P.; Ruggiero, G.; Seixas, J.; Sonderegger, P.; Sousa, P.; Usai, G.; Vandoni, G

    2002-02-01

    We have designed and built a new hodoscope for heavy ion beams consisting of two tracking stations equipped with silicon microstrip detectors operated at 130 K. Preliminary results from tests performed in the high intensity CERN-SPS Pb ion beam show that we were able to detect and identify each incoming ion up to a beam intensity of {approx}10{sup 7} ions/s. The beam profile could be monitored on-line with 50 {mu}m resolution. The detector performed satisfactory even after a dose of 90{+-}40 Grad.

  10. Current External Beam Radiation Therapy Quality Assurance Guidance: Does It Meet the Challenges of Emerging Image-Guided Technologies?

    International Nuclear Information System (INIS)

    The traditional prescriptive quality assurance (QA) programs that attempt to ensure the safety and reliability of traditional external beam radiation therapy are limited in their applicability to such advanced radiation therapy techniques as three-dimensional conformal radiation therapy, intensity-modulated radiation therapy, inverse treatment planning, stereotactic radiosurgery/radiotherapy, and image-guided radiation therapy. The conventional QA paradigm, illustrated by the American Association of Physicists in Medicine Radiation Therapy Committee Task Group 40 (TG-40) report, consists of developing a consensus menu of tests and device performance specifications from a generic process model that is assumed to apply to all clinical applications of the device. The complexity, variation in practice patterns, and level of automation of high-technology radiotherapy renders this 'one-size-fits-all' prescriptive QA paradigm ineffective or cost prohibitive if the high-probability error pathways of all possible clinical applications of the device are to be covered. The current approaches to developing comprehensive prescriptive QA protocols can be prohibitively time consuming and cost ineffective and may sometimes fail to adequately safeguard patients. It therefore is important to evaluate more formal error mitigation and process analysis methods of industrial engineering to more optimally focus available QA resources on process components that have a significant likelihood of compromising patient safety or treatment outcomes

  11. Current external beam radiation therapy quality assurance guidance: does it meet the challenges of emerging image-guided technologies?

    Science.gov (United States)

    Palta, Jatinder R; Liu, Chihray; Li, Jonathan G

    2008-01-01

    The traditional prescriptive quality assurance (QA) programs that attempt to ensure the safety and reliability of traditional external beam radiation therapy are limited in their applicability to such advanced radiation therapy techniques as three-dimensional conformal radiation therapy, intensity-modulated radiation therapy, inverse treatment planning, stereotactic radiosurgery/radiotherapy, and image-guided radiation therapy. The conventional QA paradigm, illustrated by the American Association of Physicists in Medicine Radiation Therapy Committee Task Group 40 (TG-40) report, consists of developing a consensus menu of tests and device performance specifications from a generic process model that is assumed to apply to all clinical applications of the device. The complexity, variation in practice patterns, and level of automation of high-technology radiotherapy renders this "one-size-fits-all" prescriptive QA paradigm ineffective or cost prohibitive if the high-probability error pathways of all possible clinical applications of the device are to be covered. The current approaches to developing comprehensive prescriptive QA protocols can be prohibitively time consuming and cost ineffective and may sometimes fail to adequately safeguard patients. It therefore is important to evaluate more formal error mitigation and process analysis methods of industrial engineering to more optimally focus available QA resources on process components that have a significant likelihood of compromising patient safety or treatment outcomes. PMID:18406911

  12. Development of beam halo monitors for the European XFEL using radiation hard sensors and demonstration of the technology at FLASH

    Energy Technology Data Exchange (ETDEWEB)

    Ignatenko, Alexandr

    2015-05-15

    The European X-Ray Free-Electron Laser (E-XFEL), currently under construction in Hamburg, Germany, is intended to be an international linear accelerator (linac) based user facility. Its electron beam can carry maximal average power of 600 kW. A beam with such a high power needs to be carefully transmitted through the machine and safely dumped after utilization. This is supported by various diagnostics tools. A Beam Halo Monitor (BHM) based on synthetic diamond and sapphire sensors has been designed. Diamond sensors are developed by the company element6 for the detection of ionizing radiation and used previously elsewhere. Sapphire sensors are in this thesis applied for the first time. The BHM concept has been applied already at the Free-electron Laser in Hamburg (FLASH). A module with four diamond and four sapphire sensors was designed, installed inside the beam pipe, commissioned, calibrated and has been successfully operated for 4 years. The system contributed significantly to safe and efficient operation of FLASH. Both types of the sensors for the BHM were characterized. Measurements of radiation tolerance are done in a 10 MeV electron beam for polycrystalline CVD (pCVD) diamond sensors for the first time up to a dose of 10 MGy and for sapphire sensors up to 5 MGy. The charge collection efficiency (CCE) drops as a function of the absorbed dose, is however still sufficient for application as a BHM. To improve a main sensor characteristic, the charge collection efficiency, for sapphire sensors the impurity concentration was reduced and different growth techniques were compared. Finally, charge collection efficiency of about 5 % for a bias voltage of 500 V was reached. The BHM concept for the XFEL is designed and in the construction phase.

  13. On The Deign And Construction Of A Radiation Shielding System For Development Of Neutron Beams Based On The Horizontal Channel No.2 Of Dalat Reactor

    International Nuclear Information System (INIS)

    An optimal structural system of filtered neutron beam and radiation shielding has been designed and calculated using the Monte-Carlo code MCNP5. The system was constructed and installed into the horizontal channel No. 2 of the Dalat reactor. The neutron beam is applied for experimental studies on nuclear physics, nuclear data measurements, and personal training. (author)

  14. Generation of broadband terahertz radiation using a backward wave oscillator and pseudospark-sourced electron beam

    Energy Technology Data Exchange (ETDEWEB)

    He, W.; Zhang, L.; Bowes, D.; Yin, H.; Ronald, K.; Phelps, A. D. R.; Cross, A. W. [Department of Physics, SUPA, University of Strathclyde, Glasgow, G4 0NG Scotland (United Kingdom)

    2015-09-28

    This paper presents for the generation of a small size high current density pseudospark (PS) electron beam for a high frequency (0.2 THz) Backward Wave Oscillator (BWO) through a Doppler up-shift of the plasma frequency. An electron beam ∼1 mm diameter carrying a current of up to 10 A and current density of 10{sup 8} A m{sup −2}, with a sweeping voltage of 42 to 25 kV and pulse duration of 25 ns, was generated from the PS discharge. This beam propagated through the rippled-wall slow wave structure of a BWO beam-wave interaction region in a plasma environment without the need for a guiding magnetic field. Plasma wave assisted beam-wave interaction resulted in broadband output over a frequency range of 186–202 GHz with a maximum power of 20 W.

  15. In vivo pink-beam imaging and fast alignment procedure for rat brain lesion microbeam radiation therapy

    International Nuclear Information System (INIS)

    A fast 50 µm-accuracy alignment procedure has been developed for the radiosurgery of brain lesions in rats, using microbeam radiation therapy. A fast 50 µm-accuracy alignment procedure has been developed for the radiosurgery of brain lesions in rats, using microbeam radiation therapy. In vivo imaging was performed using the pink beam (35–60 keV) produced by the ID17 wiggler at the ESRF opened at 120 mm and filtered. A graphical user interface has been developed in order to define the irradiation field size and to position the target with respect to the skull structures observed in X-ray images. The method proposed here allows tremendous time saving by skipping the swap from white beam to monochromatic beam and vice versa. To validate the concept, the somatosensory cortex or thalamus of GAERS rats were irradiated under several ports using this alignment procedure. The magnetic resonance images acquired after contrast agent injection showed that the irradiations were selectively performed in these two expected brain regions. Image-guided microbeam irradiations have therefore been realised for the first time ever, and, thanks to this new development, the ID17 biomedical beamline provides a major tool allowing brain radiosurgery trials on animal patients

  16. Guaranteed epsilon-optimal treatment plans with the minimum number of beams for stereotactic body radiation therapy

    International Nuclear Information System (INIS)

    Stereotactic body radiation therapy (SBRT) is characterized by delivering a high amount of dose in a short period of time. In SBRT the dose is delivered using open fields (e.g., beam’s-eye-view) known as ‘apertures’. Mathematical methods can be used for optimizing treatment planning for delivery of sufficient dose to the cancerous cells while keeping the dose to surrounding organs at risk (OARs) minimal. Two important elements of a treatment plan are quality and delivery time. Quality of a plan is measured based on the target coverage and dose to OARs. Delivery time heavily depends on the number of beams used in the plan as the setup times for different beam directions constitute a large portion of the delivery time. Therefore the ideal plan, in which all potential beams can be used, will be associated with a long impractical delivery time. We use the dose to OARs in the ideal plan to find the plan with the minimum number of beams which is guaranteed to be epsilon-optimal (i.e., a predetermined maximum deviation from the ideal plan is guaranteed). Since the treatment plan optimization is inherently a multi-criteria-optimization problem, the planner can navigate the ideal dose distribution Pareto surface and select a plan of desired target coverage versus OARs sparing, and then use the proposed technique to reduce the number of beams while guaranteeing epsilon-optimality. We use mixed integer programming (MIP) for optimization. To reduce the computation time for the resultant MIP, we use two heuristics: a beam elimination scheme and a family of heuristic cuts, known as ‘neighbor cuts’, based on the concept of ‘adjacent beams’. We show the effectiveness of the proposed technique on two clinical cases, a liver and a lung case. Based on our technique we propose an algorithm for fast generation of epsilon-optimal plans. (paper)

  17. Correction for patient table-induced scattered radiation in cone-beam computed tomography (CBCT)

    Energy Technology Data Exchange (ETDEWEB)

    Sun Mingshan; Nagy, Tamas; Virshup, Gary; Partain, Larry; Oelhafen, Markus; Star-Lack, Josh [Ginzton Technology Center, Varian Medical Systems, 3120 Hansen Way, Palo Alto, California 94304 (United States); Imaging Laboratory, Varian Medical Systems, Tafernstrasse 7, CH-5405 Baden-Dattwil (Switzerland); Ginzton Technology Center, Varian Medical Systems, 3120 Hansen Way, Palo Alto, California 94304 (United States); Imaging Laboratory, Varian Medical Systems, Tafernstrasse 7, CH-5405 Baden-Dattwil (Switzerland); Ginzton Technology Center, Varian Medical Systems, 3120 Hansen Way, Palo Alto, California 94304 (United States)

    2011-04-15

    Purpose: In image-guided radiotherapy, an artifact typically seen in axial slices of x-ray cone-beam computed tomography (CBCT) reconstructions is a dark region or ''black hole'' situated below the scan isocenter. The authors trace the cause of the artifact to scattered radiation produced by radiotherapy patient tabletops and show it is linked to the use of the offset-detector acquisition mode to enlarge the imaging field-of-view. The authors present a hybrid scatter kernel superposition (SKS) algorithm to correct for scatter from both the object-of-interest and the tabletop. Methods: Monte Carlo simulations and phantom experiments were first performed to identify the source of the black hole artifact. For correction, a SKS algorithm was developed that uses separate kernels to estimate scatter from the patient tabletop and the object-of-interest. Each projection is divided into two regions, one defined by the shadow cast by the tabletop on the imager and one defined by the unshadowed region. The region not shadowed by the tabletop is processed using the recently developed fast adaptive scatter kernel superposition (fASKS) method which employs asymmetric kernels that best model scatter transport through bodylike objects. The shadowed region is convolved with a combination of slab-derived symmetric SKS kernels and asymmetric fASKS kernels. The composition of the hybrid kernels is projection-angle-dependent. To test the algorithm, pelvis phantom and in vivo data were acquired using a CBCT test stand, a Varian Acuity simulator, and a Varian On-Board Imager, all of which have similar geometries and components. Artifact intensities and Hounsfield unit (HU) accuracies in the reconstructions were assessed before and after the correction. Results: The hybrid kernel algorithm provided effective correction and produced substantially better scatter estimates than the symmetric SKS or asymmetric fASKS methods alone. HU nonuniformities in the reconstructed

  18. Electro-Optical Radiation of a Charged Particle in a Single Laser Beam Field

    CERN Document Server

    Anokhin, M V; Kalegaev, V V; Nagorsky, G A; Panasiuk, M I; Chabanov, V M

    2016-01-01

    A peculiar radiation arising as a result of radiation interference of nonlinear oscillators excited by a monochromatic plane wave field of the incident particle is described. The radiation properties are determined by the fact that a phase of each oscillator radiation fields is synchronized by a wave field, while the radiation itself occurs due to the particle field influence on the oscillators. The consideration is performed for a thin film with negligible density effect. It is supposed that the contribution is given only by a long-wave part of the Weizsacker spectrum for which nonlinear polarization coefficients of medium are large.

  19. An EPID response calculation algorithm using spatial beam characteristics of primary, head scattered and MLC transmitted radiation

    International Nuclear Information System (INIS)

    We have developed an independent algorithm for the prediction of electronic portal imaging device (EPID) response. The algorithm uses a set of images [open beam, closed multileaf collimator (MLC), various fence and modified sweeping gap patterns] to separately characterize the primary and head-scatter contributions to EPID response. It also characterizes the relevant dosimetric properties of the MLC: Transmission, dosimetric gap, MLC scatter [P. Zygmansky et al., J. Appl. Clin. Med. Phys. 8(4) (2007)], inter-leaf leakage, and tongue and groove [F. Lorenz et al., Phys. Med. Biol. 52, 5985-5999 (2007)]. The primary radiation is modeled with a single Gaussian distribution defined at the target position, while the head-scatter radiation is modeled with a triple Gaussian distribution defined downstream of the target. The distances between the target and the head-scatter source, jaws, and MLC are model parameters. The scatter associated with the EPID is implicit in the model. Open beam images are predicted to within 1% of the maximum value across the image. Other MLC test patterns and intensity-modulated radiation therapy fluences are predicted to within 1.5% of the maximum value. The presented method was applied to the Varian aS500 EPID but is designed to work with any planar detector with sufficient spatial resolution

  20. Molecular beam studies of unimolecular and bimolecular chemical reaction dynamics using VUV synchrotron radiation as a product probe

    Energy Technology Data Exchange (ETDEWEB)

    Blank, D.A.

    1997-08-01

    This dissertation describes the use of a new molecular beam apparatus designed to use tunable VUV synchrotron radiation for photoionization of the products from scattering experiments. The apparatus was built at the recently constructed Advanced Light Source at Lawrence Berkeley National Laboratory, a third generation 1-2 GeV synchrotron radiation source. The new apparatus is applied to investigations of the dynamics of unimolecular reactions, photodissociation experiments, and bimolecular reactions, crossed molecular beam experiments. The first chapter describes the new apparatus and the VUV radiation used for photoionization. This is followed by a number of examples of the many advantages provided by using VUV photoionization in comparison with the traditional technique of electron bombardment ionization. At the end of the chapter there is a discussion of the data analysis employed in these scattering experiments. The remaining four chapters are complete investigations of the dynamics of four chemical systems using the new apparatus and provide numerous additional examples of the advantages provided by VUV photoionizaiton of the products. Chapters 2-4 are photofragment translational spectroscopy studies of the photodissociation dynamics of dimethyl sulfoxide, acrylonitrile, and vinyl chloride following absorption at 193 mn. All of these systems have multiple dissociation channels and provide good examples of the ability of the new apparatus to unravel the complex UV photodissociation dynamics that can arise in small polyatomic molecules.