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Sample records for cervical abrasion lesions

  1. An easy classification for dental cervical abrasions

    OpenAIRE

    Madhuri Alankar Sawai

    2014-01-01

    Introduction: Tooth wear - attrition, abrasion, or erosion - are modern day problems for dentistry. It usually leads to discomfort and sensitivity especially during eating, drinking, or tooth brushing. If left untreated for a long time, it may lead to loss of vitality of tooth. Various qualitative and quantitative methods have been used in the past to describe tooth wear. However, each method has certain shortfalls. There is no ideal index that is simple and clear in its scoring criteria. The...

  2. Cervical premalignant lesions and their management

    OpenAIRE

    Köse, Faruk M.; Naki, Murat M.

    2014-01-01

    Cervical cancer is the tenth most common cancer in women in developed countries that have national screening programs, while it is in the second line in underdeveloped countries. According to Ministry of Health registry data, cervical cancer is the eighth most common cancer among female cancers in Turkey. Today, the most effective screening for cervical cancer is to obtain smears from the cervix. Therefore, periodic screening programs are of great importance in identifying preinvasive lesions...

  3. 两种排龈方法在楔状缺损修复中的应用研究%Study of two gingival retraction techniques used in restoring cervical abrasion lesions

    Institute of Scientific and Technical Information of China (English)

    王聪

    2012-01-01

    Objective To investigate the influence of two gingival retraction techniques on the periodontium and clinical performance before the restoration of cervical lesion. Methods 150 teeth with cervical lesion of 50 patients were selected. The teeth were divided into 3 groups randomly. In the experiment group, a conventional retraction cord ( Ultrapaks) and a paste-like material (Expasyls) were applied on the buccal aspects of each subject. In the control group, no gingival retraction techniques was applied before restoration and filled directly. Bleeding on probing and the pain were assessed after application. The retention, marginal adaptation, the presence of secondary caries and the GI after one year were evaluated . Data were analysed using Chi-Square and Kruskal - Wallis tests (a = 0. 05). Results There were significant difference between the rates of subjective feeling of the Ultrapaks and Expasyls. Bleeding was only induced by Ultrapaks in five subjects. After one year, the differences between the experimental and control groups in GI and marginal adaptation were of statistical significance ( P < 0.05 ). While there were no significant difference between the two control groups. The retention of the restoration and the presence of secondary caries were not statistically significant among the 3 groups. Conclusion Utilization of gingival retraction techniques before the restoration of cervical lesions can efficiently improve the quality of the restoration and the two gingival retraction methods were not statistically significant. The cordless gingival retraction technique is more easy, feasible, rapid than the retraction cord.%目的 研究在楔状缺损修复前使用两种排龈方法对其牙周组织及充填效果的影响.方法 选择50例全口至少有3个楔状缺损位于龈缘或龈下的患者(150颗患牙),每例患者的患牙随机分为3组,对照组直接树脂修复,实验组分别用ULTRA排龈线,Expusyl排龈膏排龈后再充填.分别

  4. Os Odontoideum: Rare Cervical Lesion

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    Kristie A Robson

    2011-05-01

    Full Text Available We report the case of a 22-year-old Marine who presented to the emergency department, after a martial arts exercise, with transient weakness and numbness in all extremities. Computed tomography cervical spine radiographs revealed os odontoideum. Lateral flexion–extension radiographs identified atlanto-axillary instability. This abnormality is rare and can be career ending for military members who do not undergo surgical fusion. [West J Emerg Med. 2011;12(4:520–522.

  5. Photodynamic therapy for cervical lesions

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    E. V. Grebenkina

    2014-01-01

    Full Text Available The experience of treatment for precancer and early cervical cancer by photodynamic therapy in 12 patients with primary diagnosis H-SIL (CIN II–III and cancer in situ is described. Chlo-rine photosensitizer Photolon was given intravenously at a dose of 0.75–1.15 mg/kg body weight. 2.5 h later the treatment with polyposition laser exposure (light dose – 150 J/cm2, light power density – 400–500 mW/cm2 was made. Thirty days later conization of the cervix with endocervical curettage assessing therapeutic response of cervical tumor tissue was per-formed. According to histological data complete response was in 4 patients, minute foci of CIN I were determined in 7 patients, 1 patient had foci of CIN II. 8 of 10 HPV-positive patients had complete eradication of HPV after treatment. There were no serious adverse events after light exposure. Marked therapeutic response, high anti-viral activity and good feasibility allow to consider photodynamic therapy as alternative organ-sparing treatment of early cancer and pre-cancer of cervix. 

  6. TTV and HPV co-infection in cervical smears of patients with cervical lesions

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    Tachezy Ruth

    2009-07-01

    Full Text Available Abstract Background The female lower genital tract is a gateway for pathogens entering the host through the mucous membrane. One of the prevalent human viruses is Torque teno virus (TTV. The major reported routes of TTV transmission are fecal-oral and parenteral. Furthermore, other modes of transmission, e.g. sexual contact, are suggested. To investigate the sexual route of TTV transmission, cervical smears of healthy women and those with cervical lesions were screened for the presence of TTV DNA. Methods TTV DNA was studied in cervical smears of 95 patients with cervical lesions and 55 healthy women. Paired serum samples were available from 55 and 42 women, respectively. All healthy women had normal cytology while 44 patients had histologically confirmed low-grade lesion (LGL and 51 high-grade lesion (HGL. TTV DNA was detected with primers specific for the non-coding region. In 40 paired cervical smears and serum samples, the phylogenetic group of TTV isolates was determined. The presence of HPV DNA in cervical smears was detected by means of PCR with MY09/11 primers. Results The prevalence of TTV DNA in cervical smears of healthy women was 52.7% and was comparable with that in paired serum samples (50%. Symptomatic women had significantly higher prevalence of TTV DNA in cervical smears (74.7% than healthy controls. The TTV DNA prevalence in patient serum samples was 51%. The phylogenetic groups of TTV serum isolates were concordant with those of TTV from cervical smears of the same subjects. In cervical smears, a wider variety of TTV isolates was found. The viral loads in cervical smears were 10 to 1000 times as high as in sera. The HPV-positive study subjects had significantly higher TTV DNA prevalence than HPV negatives. The prevalence of TTV was not associated with disease severity. Conclusion High prevalence of TTV in cervical smears suggests that sexual transmission is another mode of expansion of TTV infection among the population. The

  7. Sialyl Lewis x expression in cervical scrapes of premalignant lesions

    Indian Academy of Sciences (India)

    Noé Velázquez-Márquez; Gerardo Santos López; Lucio Jiménez Aranda; Julio Reyes Leyva; Verónica Vallejo Ruiz

    2012-12-01

    Sialylated oligosaccharides of glycoproteins and glycolipids have been implicated in tumour progression and metastases. Altered expression of glycosidic antigens has been reported in cervical cancer. In cervix premalignant lesions, an increased expression of sialic acid has been reported. In the present study we determined the expression profiles of the glycosidic antigens Tn, sialyl Tn (sTn), Lewis a (Lea), sialyl Lewis a (sLea), Lewis x (Lex) and sialyl Lewis x (sLex) in cervical scrapes with cytological diagnoses of normal, low-grade squamous intraepithelial lesions (LGSIL) and high-grade squamous intraepithelial lesions (HGSIL). Cervical scrapings were collected to detect tumour antigens expressions by flow cytometry using monoclonal antibodies. Cytometry analysis of Tn, sTn, Lea and Lex did not reveal differences at the expression level among groups. The number of positive cells to sLea antigen increased in the HGSIL group with respect to the normal group (=0.0495). The number of positive cells to sLex antigen in the samples increased with respect to the grade of squamous intraepithelial lesion (SIL) ( < 0.001, Mann–Whitney U test). The intensity of expression of this antigen increased in the HGSIL samples with respect to normal samples ( < 0.0068). sLex antigen could be a candidate to be used as biomarker for the early diagnosis of cervical cancer.

  8. ASSESSING PROGRESSION OF CERVICAL PRE-CANCER LESIONS

    OpenAIRE

    Dragos Crauciuc; Ovidiu Toma; Eduard Crauciuc

    2016-01-01

    The purpose of this study was to accomplish a comparative assessment between the immune histochemical and the immunocytochemical expression of p16 protein and L1 major capsid protein of HPV respectively, in cervical squamous intraepithelial lesions with low and high grade, in order to determine, through morphological and clinical correlations, their applicability into practice when diagnosing and further monitoring the patients. There were 119 patients included in the study, havin...

  9. Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells

    International Nuclear Information System (INIS)

    Abnormal expression of Rho-GTPases has been reported in several human cancers. However, the expression of these proteins in cervical cancer has been poorly investigated. In this study we analyzed the expression of the GTPases Rac1, RhoA, Cdc42, and the Rho-GEFs, Tiam1 and beta-Pix, in cervical pre-malignant lesions and cervical cancer cell lines. Protein expression was analyzed by immunochemistry on 102 cervical paraffin-embedded biopsies: 20 without Squamous Intraepithelial Lesions (SIL), 51 Low- grade SIL, and 31 High-grade SIL; and in cervical cancer cell lines C33A and SiHa, and non-tumorigenic HaCat cells. Nuclear localization of Rac1 in HaCat, C33A and SiHa cells was assessed by cellular fractionation and Western blotting, in the presence or not of a chemical Rac1 inhibitor (NSC23766). Immunoreacivity for Rac1, RhoA, Tiam1 and beta-Pix was stronger in L-SIL and H-SIL, compared to samples without SIL, and it was significantly associated with the histological diagnosis. Nuclear expression of Rac1 was observed in 52.9% L-SIL and 48.4% H-SIL, but not in samples without SIL. Rac1 was found in the nucleus of C33A and SiHa cells but not in HaCat cells. Chemical inhibition of Rac1 resulted in reduced cell proliferation in HaCat, C33A and SiHa cells. Rac1 is expressed in the nucleus of epithelial cells in SILs and cervical cancer cell lines, and chemical inhibition of Rac1 reduces cellular proliferation. Further studies are needed to better understand the role of Rho-GTPases in cervical cancer progression

  10. Percutaneous vertebroplasty for metastatic lesions of the cervical spine

    International Nuclear Information System (INIS)

    Objective: To assess the safety and effectiveness of percutaneous vertebroplasty (PVP) performed via three different routes for the treatment of osteolytic metastatic lesions of the cervical spine. Methods: A total of 36 patients with osteolytic cervical metastases (57 cervical vertebrae involved) received the treatment of the PVP. The clinical data were retrospectively analyzed. The WHO standards and visual analogue scale (VAS) were assessed before and after the operation, and the application of three operative accesses (anterolateral approach, lateral approach and anterolateral approach through disc space) was discussed. Results: The puncturing accesses used in three groups were anterolateral approach, lateral approach and anterolateral approach through disc space. The whole procedure, including puncturing and injection of bone cement, was successfully accomplished for all diseased cervical vertebral bodies. All patients were followed up for three months. Of 32 patients who had complete clinical data, complete remission (CR) was obtained in 11, partial remission (PR) in 20, mild remission (MR) in one and no remission (NR) in zero. The clinical effectiveness (CR + PR) was 97%. The VAS scores before operation as well as 24 hours, one week and 3 months after the operation were separately determined, and four groups of data were obtained. Statistically significant difference in VAS scores existed between each other of the above four data groups (P<0.05). A little bone cement leakage was observed in 17 vertebral bodies (29.82%), however, no serious clinical complications occurred. Conclusion: Percutaneous vertebroplasty via anterolateral approach is a safe and effective technique for the treatment of osteolytic metastases located at lower cervical vertebrae (C4-C7). While in treating metastatic lesions invaded the vertebra of C1, PVP via lateral approach should be employed. For C2 and C3 vertebral involvement, PVP via anterolateral approach through disc space should

  11. Vertebral locking lesion following cervical spine fracture in ankylosing spondylitis.

    Science.gov (United States)

    Kuroiwa, Tomoyuki; Yoshii, Toshitaka; Sakaki, Kyohei; Inose, Hiroyuki; Tomizawa, Shoji; Kato, Tsuyoshi; Kawabata, Shigenori; Shinomiya, Kenichi; Okawa, Atsushi

    2012-06-01

    Spine fractures in patients with ankylosing spondylitis frequently extend to all 3 columns, which can lead to displacement and deformity with severe instability. Cervical spine fractures occasionally cause severe kyphotic deformities, such as chin-on-chest deformities. In such cases, the patients typically exhibit a chronic progression of hyperkyphosis after the traumatic event. This article describes a unique case of ankylosing spondylitis associated with an acute chin-on-chest deformity following a spine fracture due to a vertebral locking lesion.A 60-year-old man fell while walking and sustained a compression fracture of the C6 vertebra. Two weeks later, the patient acutely developed an inability to raise his head, difficulties with chewing and swallowing, and a horizontal gaze. Radiographs demonstrated a severe kyphosis in the cervical spine with a locking lesion between the anterior wall of the C5 and C6 vertebrae. The patient also presented with neurological impairment in his hands. Because the anterior approach to the spine was anatomically impossible, halo traction was initially applied under a close observation of neurological symptoms. Three days after halo traction, release of the vertebral locking lesion and realignment of the spine were seen. The patient subsequently underwent spinal fusion using a combined anterior-posterior approach.Postoperatively, neurological dysfunction improved, and solid fusion was confirmed at 6 months. In cases of acute kyphotic deformity following cervical spine fracture in ankylosing spondylitis patients, halo traction followed by circumferential spine fusion is a safe and effective approach for improving the alignment and stability of the spine. PMID:22691645

  12. Studies of cervical caps: I. Vaginal lesions associated with use of the Vimule cap.

    Science.gov (United States)

    Bernstein, G S; Kilzer, L H; Coulson, A H; Nakamura, R M; Smith, G C; Bernstein, R; Frezieres, R; Clark, V A; Coan, C

    1982-11-01

    Prior to investigating the contraceptive efficacy of cervical caps, we undertook a preliminary study to evaluate potential side effects of these devices. Women who had not previously used a cap were randomly assigned to wear either a Vimule or Cavity Rim Cap (CRC) for as long as seven days. The Vimule cap caused lesions of the portio vaginalis ranging from erythematous impressions to abrasions and frank lacerations. There was variation in the degree of trauma depending, in part, on the size of the cap and duration of wear. Disruption of the epithelium occurred in eight of twelve Vimule users, but the lesions were sometimes difficult to see owing to their location. CRCs were worn by 20 women. This device sometimes left a "suction ring" on the cervix but did not disrupt the epithelium. Two of three long-term users of the Vimule cap who were also studied had unusual formations of the vaginal mucosa suggesting a proliferative reaction to chronic irritation. It is recommended that all women using a Vimule Cap be carefully re-examined and counseled about further use of the device according to the findings of the examination. PMID:7160179

  13. Colour improvement and stability of white spot lesions following infiltration, micro-abrasion, or fluoride treatments in vitro

    OpenAIRE

    Yetkiner, Enver; Wegehaupt, Florian; Wiegand, Annette; Attin, Rengin; Attin, Thomas

    2014-01-01

    SUMMARY BACKGROUND/OBJECTIVES White spot lesions (WSLs) are unwelcome side effects of fixed appliances that compromise the treatment outcome. Recently, infiltration of WSLs has been introduced as a viable treatment alternative. The objective was to evaluate the colour improvement of WSLs and their stability against discolouration following infiltration, fluoride, or micro-abrasion treatments in vitro. MATERIALS/METHODS Artificial WSLs were created in bovine enamel (N = 96) using acidic buf...

  14. REPRODUCTIVE ASPECTS ASSOCIATED WITH PRECURSOR LESIONS FOR CERVICAL CANCER

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    Rogério Ferrari

    2013-05-01

    Full Text Available To investigate the relationship between reproductive variables and theprecursor lesions for cervical cancer in women attended the clinic of the lower genitaltract pathology and colposcopy (PTGIC, packed in the complex regional healthCaceres city, southwest of Mato Grosso, in the year 2009.Methods:We conducted across sectional study with data collection from medical records of 142 women withabnormal cytology, colposcopy and positive underwent directed biopsy, taking intoaccount the reproductive variables.Results:indicate that the minimum age at menarchewas 9 years and maximum age was 17 years, mean 12.6 years; on the average paritywas 3.4 children, the use of hormonal contraceptive method corresponds to 34 5% and38.1% female sterilization research, 46.5% are or have use of contraception for a periodgreater than five years, with a mean of 4.7 years and 67.2% of women surveyed do notuse condoms. The variables were not significantly associated to cervical cancer.Conclusion:the characteristics of the women studied may serve as a basis for workdirected to this population in order to seek to minimize this problem.Although the dataobtained were satisfactory, it was possible to trace the profile of the reproductiveaspects of women in the Clinic ofPTGIC, there is a lack of association betweenreproductive aspects and findings of the cervical biopsy, it may be associated with somelimiting factors of the study that need to be balanced

  15. [P16NIK4a expression in premalignant cervical lesions].

    Science.gov (United States)

    Bolanca, Ines Krivak; Simon, Suzana Katalenić; Sentija, Karmela; Duić, Zeljko; Kukura, Vlastimir; Zovko, Gojko; Valetić, Josip; Vranes, Jasmina

    2011-09-01

    Increased expression of viral E6 and E7 oncoproteins within the host cells results in an increase in cellular protein p16INK4a expression. That increase may serve as a marker for dysplastic and neoplastic cells of the uterine cervical epithelium. The aim of this study is to assess the p16INK4a protein expression in different stages of cytological abnormality in correlation with the proven high oncogenic risk human papillomavirus infection in order to demonstrate its value as the diagnostic marker. The study included cervical smear samples of 371 patient in whom the viral typization was done. In 171 patient, during their regular gynaecological examination, along with conventional Pap smear sampling an additional smear was taken. Two hundred cervix brush (Rovers Medical DevicesOss, the Netherlands) samples were obtained and analyzed by the LBC method and the ThinPrep2000 machine. All samples were analyzed cytologically, classified according to the Bethesda system, and immunostained with the p16INK4a-specific monoclonal antibody E6H4 (MTM Laboratories, Heidelberg, Germany). A significant difference is seen in p16 positivity between the cytological diagnosis of a high grade cervical squamous intraepithelial lesion and the group with mild dysplasia (chi2=146,48; D.F.=4; ptechnique renders it suitable for follow-up monitoring as well as for comparison of the cytological results. PMID:23126030

  16. Cervical Lesions in Women Younger than 25 Years

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    Yoleisi Alonso Fleites

    2011-12-01

    Full Text Available Fundamento: el cáncer cervical es esencialmente una enfermedad de transmisión sexual relacionada con la infección por el virus del papiloma humano. Este fenómeno ha aumentado globalmente, en especial en mujeres cada vez más jóvenes. Objetivo: determinar las lesiones de cuello uterino en mujeres menores de 25 años. Métodos: estudio observacional, descriptivo y correlacional que incluyó 248 pacientes registradas en el Servicio de Anatomía Patológica del Hospital General Universitario Dr. Gustavo Aldereguía Lima de Cienfuegos, en el periodo de enero a diciembre de 2007 y primer trimestre del 2008. Se analizaron: edad, edad de primera relación sexual, número de parejas sexuales, tipo de lesión, grado de la lesión y motivo de consulta. Resultados: predominaron las mujeres de más de 21 años y las que tuvieron 2 y 3 parejas sexuales; el principal motivo de consulta fue la cervicitis (84, 7 %; en el 22,6 % de las mujeres se detectó neoplasia intraepitelial grado I, en el 41, 9 % de grado II y en el 33, 1 % de grado III. En el 90 % de las pacientes más jóvenes la lesión fue  maligna. Conclusiones: la presencia de lesiones de cuello uterino en mujeres menores de 25 años no es baja, como tampoco la frecuencia de lesiones malignas.

  17. Detecting uterine glandular lesions: Role of cervical cytology

    Science.gov (United States)

    Bansal, Baneet; Gupta, Parikshaa; Gupta, Nalini; Rajwanshi, Arvind; Suri, Vanita

    2016-01-01

    Background: The sensitivity of cervical cytology for detection of glandular lesions is reported to be low. We conducted this study to assess the diagnostic accuracy of cervical Papanicolaou (Pap) smears for uterine glandular lesions and to compare the diagnostic utility of conventional and liquid-based cytology (LBC) smears for glandular lesions. Materials and Methods: Archived histopathology records of all cases reported as endocervical and endometrial adenocarcinoma in the study period were identified and the available corresponding Pap smears (in preceding 1 year) were retrieved. In addition, the Pap smears reported as glandular cell abnormalities (GCA) during the same study period were retrieved. The overall prevalence of GCA, sensitivity, and specificity of Pap smears for the detection of GCA was calculated. The diagnostic accuracy of conventional and LBC smears for the diagnosis of GCA was also compared. Results: The prevalence of GCA in our study was 0.32%. The overall specificity of Pap smears for the diagnosis of GCA was 60.8%, this was not significantly different between conventional and LBC smears (P = 0.4). The overall sensitivity of Pap smears for the detection of GCA was 41.8%; LBC smears had significantly better sensitivity as compared to conventional smears for the detection of endometrial as compared to endocervical adenocarcinoma (P Pap smears is low. The specificity of Pap smears, for diagnosis of GCA, was found to be moderate. However, the overall sensitivity of Pap smears for the detection of GCA was low, though better for LBC as compared to conventional smears. PMID:27014363

  18. Prevalence and risk factors for cervical cancer and pre-cancerous lesions in Rwanda

    OpenAIRE

    Makuza, Jean Damascène; Nsanzimana, Sabin; Muhimpundu, Marie Aimee; Pace, Lydia Eleanor; Ntaganira, Joseph; Riedel, David James

    2015-01-01

    Introduction Cervical cancer prevalence in Rwanda has not been well-described. Visual inspection with acetic acid or Lugol solution has been shown to be effective for cervical cancer screening in low resource settings. The aim of the study is to understand the prevalence and risk factors for cervical cancer and pre- cancerous lesions among Rwandan women between 30 and 50 old undergoing screening. Methods This cross-sectional analytical study was done in 3 districts of Rwanda from October 2010...

  19. A Correlative Analysis of Cervical Lesions in Patients with Vulva Condyloma Acuminatum

    Institute of Scientific and Technical Information of China (English)

    Qing Li; Weihong Li; Huanzi Li; Zhihua Liu

    2006-01-01

    OBJECTIVE To analyze the relation ship among vulva condyloma acuminatum, high-risk human papillomavirus (HPV) infections and cervical epithelium lesions.METHODS From May 2002 to April 2004 patients with vulva condyloma acuminatum were examined employing vulva biospy, colposcopy, highrisk HPV-DNA test and cervical bioscopy.RESUTS In 418 cases of vulva condyloma acuminatum, verified by pathologic analysis, high-risk HPV (+) infections were detected in 68.7% (287/418) of the cases. Among those patients, 20.6% (59/287) had concurrent subclinical cervical intraepithelial neoplastic (CIN) lesions. Among the high-risk HPV(-) 31.3 % (131), patients 7.6% (10/131) had concurrent subclinical CIN lesions. Pathological examination results: cervicitis,167 (40.0%); cervical HPV infection, 182 (43.5%); CIN-Ⅰ, 51(12.2%); CIN-Ⅱ, 16 (3.83%); CIN-Ⅲ, 2 (0.5%); cervical cancer, none. Another patient had vulva condyloma acuminatum with valva intraepithelial neoplasia (VIN) Ⅱ~Ⅲ.CONCLUSION It was concluded that simultaneous cervical HPV infection of many types was rather common in patients with vulva condyloma acuminatum. Vulva condyloma acuminatum is the chief clinical symptom which hints at a high possibility of infection with high-risk HPV. The patients are at high-risk for CIN and cervical cancer. We must pay more attention to the cervix in cases with vulva condyloma acuminatum.

  20. Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women

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    Vidal Adriana C

    2011-11-01

    Full Text Available Abstract Background Infection with human papillomavirus (HPV is associated with uterine cervical intraepithelial neoplasia (CIN and invasive cancers (ICC. Approximately 80% of ICC cases are diagnosed in under-developed countries. Vaccine development relies on knowledge of HPV genotypes characteristic of LSIL, HSIL and cancer; however, these genotypes remain poorly characterized in many African countries. To contribute to the characterization of HPV genotypes in Northeastern Tanzania, we recruited 215 women from the Reproductive Health Clinic at Kilimanjaro Christian Medical Centre. Cervical scrapes and biopsies were obtained for cytology and HPV DNA detection. Results 79 out of 215 (36.7% enrolled participants tested positive for HPV DNA, with a large proportion being multiple infections (74%. The prevalence of HPV infection increased with lesion grade (14% in controls, 67% in CIN1 cases and 88% in CIN2-3. Among ICC cases, 89% had detectable HPV. Overall, 31 HPV genotypes were detected; the three most common HPV genotypes among ICC were HPV16, 35 and 45. In addition to these genotypes, co-infection with HPV18, 31, 33, 52, 58, 68 and 82 was found in 91% of ICC. Among women with CIN2-3, HPV53, 58 and 84/83 were the most common. HPV35, 45, 53/58/59 were the most common among CIN1 cases. Conclusions In women with no evidence of cytological abnormalities, the most prevalent genotypes were HPV58 with HPV16, 35, 52, 66 and 73 occurring equally. Although numerical constraints limit inference, findings that 91% of ICC harbor only a small number of HPV genotypes suggests that prevention efforts including vaccine development or adjuvant screening should focus on these genotypes.

  1. APPLICATION OF THE 2014 BETHESDA SYSTEM FOR REPORTING OF CERVICAL/VAGINAL CYTOLOGICAL LESIONS

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    Pratima

    2015-12-01

    Full Text Available Pap smear (Conventional smear is the most widely used cervical cancer screening test in the world. Negative intraepithelial lesion for malignancy, squamous intraepithelial lesion and cervical cancer remain important health problems for women worldwide. In developing countries like India, there is a great need for mass screening program for cervical lesion. AIMS AND OBJECTIVES To assess the clinician utility of The 2014 Bethesda System Reporting of cervical and vaginal epithelial abnormalities. MATERIAL AND METHODS All the cervical/vaginal cytology smears reported were retrieved and reviewed in the duration from 2007, 2008, 2009 and 2014. RESULTS A total number of 1700 cases of Pap smears were retrieved during period of study, out of which 90.0% were satisfactory for evaluation; 35.5% were within normal limit and 55.6% were NILM. A few (8.14% of the cases were reported as squamous intraepithelial lesion; 0.5% as atypical squamous cells and 0.19% were reported as atypical glandular cells. CONCLUSION Pap smear is a proven tested tool for making an early diagnosis and treating cervical cancer in early stage. Thus, Pap smear is simple, less expensive diagnostics tool suitable for implementation in India.

  2. Computed tomography in the foramen magnum and high cervical cord lesion

    Energy Technology Data Exchange (ETDEWEB)

    Isu, T.; Ito, T.; Iwasaki, Y.; Tsuru, M. (Hokkaido Univ., Sapporo (Japan). School of Medicine); Kitaoka, K.

    1981-10-01

    The value of computed tomography in the spine and spinal cord disease recently has been well documented. However, little attention is made to the role of computed tomography in foramen magnum and high cervical cord lesion. We report 16 cases of the foramen magnum and high cervical cord lesion. Method: Either EMI Head Scanner, CT 1010 (slice thickness 10 mm) or EMI Whole Body Scanner, CT 5005 (slice thickness 13 mm) was used. In 9 cases enhanced CT with intravenous injection of contrast medium was performed. Eleven cases received intrathecal injection of metrizamide. Materials: 1) control group without cervical pathology 70 cases, 2) spinal cord tumor 6 cases, 3) atlanto-axial dislocation 6 cases, 4) Chiari malformation (type 1) 3 cases, 5) spinal foreign body (acupuncture needle) 1 case. Results: 1. plain CT. 1) In control group without cervical pathology the cervical cord at C/sub 1/ level was seen as area surrounded by ring of subarachnoid space. 2) In 14 cases except for 1 case of atlanto-axial dislocation and 1 case of spinal foreign body identification of the cervical cord at C/sub 1/ level was impossible. 3) CT was of diagnostic value in detecting altanto-axial dislocation and spinal foreign body. 2. enhanded CT. Meningioma and neurinoma showed positive contrast enhancement. However, astrocytoma and herniated cerebellar tonsils were not detectable. 3. CT metrizamide myelography visualized the subarachnoid space and made it possible to localize the lesion in the spinal canal in relation to the spinal cord. Conclusion: Attention should be given to plain CT finding at C/sub 1/ level in diagnosis of foramen magnum and high cervical cord lesion. If identification of cervical cord at C/sub 1/ level is impossible, it is suspected that subarachnoid space is blocked by the lesion, and enhanced CT and CT metrizamide myelography must be performed.

  3. Cervical intraepithelial lesions in females attending Women's Health Clinics in Alexandria, Egypt

    OpenAIRE

    Mona Abdel-Hadi; Adel Khalaf; Hanaa Aboulkassem; Noha Naeem; Mohamed Abdel Baqy; Hassan Sallam

    2015-01-01

    Background: Data from Egyptian studies provide widely varying estimates on the prevalence of preinvasive cervical lesions. The aim of this study was to estimate the rate of cervical intraepithelial neoplasia (CIN)   in Egyptian women living in Alexandria to clarify the need for implementing a national organized screening program and a vaccination program in our community. Materials and Methods: The study was conducted over a 6 years period and covered the different socioeconomic levels to hav...

  4. Human papillomavirus infection in couples with female low-grade intraepithelial cervical lesion.

    Science.gov (United States)

    Simon, Philippe; Roumeguere, Thierry; Christophe Noël, Jean

    2010-11-01

    Low-grade squamous intraepithelial lesions (LSIL) are frequently found during cervical cancer screening. Usually they are associated with a human papillomavirus (HPV) infection. Does the high-transmission rate of HPV infection to the male partner represent a clinical risk for him? Are preventive measures to be taken to prevent the occurrence of male diseases? More than 80% of all LSIL are associated with HPV infections. The prevalence of HPV infection in males can range up to 40%, with 60% of the male partners of LSIL female patients presenting with penile flat lesions. The spontaneous cure rate for male infections is very high (90% at 5 years) but negative consequences in females (cervical high-grade lesion and cervical cancer) are frequent. Their male counterparts are far rarer but in some patients can require deleterious treatment. Transmission prevention by the use of condoms and circumcision is discussed. The effectiveness of HPV vaccination in this situation has not been validated. PMID:20646823

  5. CADM1 and MAL methylation status in cervical scrapes is representative of the most severe underlying lesion in women with multiple cervical biopsies.

    Science.gov (United States)

    van Baars, Romy; van der Marel, Jacolien; Snijders, Peter J F; Rodriquez-Manfredi, Agata; ter Harmsel, Bram; van den Munckhof, Henk A M; Ordi, Jaume; del Pino, Marta; van de Sandt, Miekel M; Wentzensen, N; Meijer, Chris J L M; Quint, Wim G V

    2016-01-15

    Recent studies have shown that CADM1/MAL methylation levels in cervical scrapes increase with severity and duration of the underlying cervical intraepithelial neoplasia (CIN) lesion. Multiple lesions of different histological grades and duration are frequently present on the cervix. To gain more insight into the possible epigenetic heterogeneity and its consequences for the methylation status in cervical scrapes, we performed an exploratory study of CADM1/MAL methylation in different grades of CIN lesions present in women with multiple cervical biopsies. CADM1-M18 and MAL-M1 methylation was assessed using a standardised, multiplex, quantitative methylation specific PCR on 178 biopsies with various grades of CIN in 65 women, and in their corresponding cervical scrapes. CADM1/MAL methylation positivity increased with disease severity, from 5.5% in normal biopsies to 63.3% and 100% in biopsies with CIN3 and cervical cancer, respectively. In the majority (8/9) of women where besides a CIN2/3 lesion a biopsy from normal cervical tissue was present, the CIN2/3 biopsy was CADM1/MAL methylation positive and the normal biopsy was CADM1/MAL methylation negative. A good concordance (78%) was found between CADM1/MAL methylation results on the scrapes and the biopsy with the worst diagnosis, particularly between samples of women with CIN3 and cervical cancer (92% and 100% concordance, respectively). Thus, in women with multiple cervical biopsies, CADM1/MAL methylation increases with severity of the lesion and is lesion-specific. CADM1/MAL methylation status in cervical scrapes appears to be representative of the worst underlying lesion, particularly for CIN3 and cervical cancer. PMID:26219541

  6. Dinamics of HPV Infection among Women with Cervical Lesions

    OpenAIRE

    E. Nikitina; Urazova, L.; Churuksaeva, O.

    2011-01-01

    A total of 293 women treated at Tomsk Cancer Research Institute were examined. HPV type 16 had the highest incidence rate (45.0%) followed by HPV 31-17,0%, HPV 56/33-15,0%, HPV 51/18/52-13,0%, HPV 58/35/39/45-7,0%, HPV 59-5,0%. Persistent infection was detected in 35.7% of primarily HPV-positive cases (10 out of 28 patients), mainly in cervical cancer patients. Total number of primarily HPV-positive and HPV-negative patients with cervical cancer was 95.0% and 5.0%, respectively. The correspon...

  7. Prevalence of cervical neoplastic lesions and Human Papilloma Virus infection in Egypt: National Cervical Cancer Screening Project

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    Dandash Khadiga

    2007-07-01

    Full Text Available Abstract Background Data from Egyptian studies provide widely varying estimates on the prevalence of pre-malignant and malignant cervical abnormalities and human papilloma virus (HPVs infection. To define the prevalence and risk factors of pre-invasive and invasive cervical cancer (cacx, a community based full-scale cross sectional, household survey including 5453 women aged between 35 and 60 years was conducted. Methods The study period was between February 2000 and December 2002. Initially, conventional Papanicolaou (Pap smears were evaluated using the Bethesda system (TBS, followed by colposcopic guided biopsy (CGB for all epithelial abnormalities (EA. In a third step, HPV was tested on all EA by in-situ hybridization (ISH using first the broad spectrum HPV probe recognizing HPVs 6, 11, 16, 18, 30, 31, 35, 45, 51 and 52 followed by subtyping with probes 6/11, 16/18 and 31/33. Lastly, unequivocal cases were immunostained for herpes simplex type-2 (HSV-2, cytomegalovirus (CMV, and human immunodeficiency virus (HIV. Results EA representing 7.8% (424/5453, were categorized into atypical squamous cell of undetermined significance (ASCUS (34.4%, atypical glandular cell of undetermined significance (AGCUS (15.3%, combined ASCUS and AGCUS (3.1%, low grade squamous intraepithelial lesions (SIL (41.0%, high grade SIL (5.2% and invasive lesions (1%. CGB of EA (n = 281 showed non neoplastic lesions (12.8%, atypical squamous metaplasia (ASM (19.2%, cervical intraepithelial neoplasia I (CIN (44.4%, CIN II (4.4%, CINIII (2.8%, endocervical lesions (5.2%, combined squamous and endocervical lesions (10.0%, invasive squamous cell carcinoma (SCC (0.02% and extranodal marginal zone B cell lymphoma (MZBCL (0.02%. The overall predictive value of cytology was 87% while the predictive value for high grade lesions was 80%. On histological basis, HPVs were present in 94.3% of squamous lesions while it was difficult to be identified in endocervical ones. ISH revealed

  8. Quantitative Detection of Screening for Cervical Lesions with ThinPrep Cytology Test

    Institute of Scientific and Technical Information of China (English)

    Hong-xin ZHANG; Yi-min SONG; Su-hong LI; Yu-hui YIN; Dong-ling GAO; Kui-sheng CHEN

    2010-01-01

    OBJECTIVE To investigate the available parameters in gynecological screening for cervical lesions by liquid-based cytology technology (ThinPrep Cytology Test, TCT) and The Bethesda System (TBS), also with computer image analysis. METHODS With application of the image analysis system, all grades of cervical lesion cells were detected quantitatively and sorted in atypical squamous cells of undetermined significance (ASCUS), atypical squamous cells-cannot exclude HSIL (ASC-H), low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL) and cervical squamous cell carcinoma (SCC) with the mean optical density (MOD), average grey (AG), positive units (PU), and nucleus to cytoplasmic ratio (N:C). Differences between each group of cells were compared and analyzed statistically.RESULTS Apart from four stereologic parameters in LSIL and HSIL groups there were no differences among them, in the other groups, there was statistically significant in differences between MOD, AG and PU values. Differences between them in the ratio of nucleus to cytoplasm were highly statistically signifi cant. CONCLUSION Stereological indexes may serve as a screening tool for cervical lesions. The image analysis system is expected to become a new means of cytological assisted diagnosis.

  9. 5-year clinical performance of resin composite versus resin modified glass ionomer restorative system in non-carious cervical lesions

    DEFF Research Database (Denmark)

    Franco, Eduardo Batista; Benetti, Ana Raquel; Ishikiriama, Sérgio Kiyoshi;

    2006-01-01

    To comparatively assess the 5-year clinical performance of a 1-bottle adhesive and resin composite system with a resin-modified glass ionomer restorative in non-carious cervical lesions.......To comparatively assess the 5-year clinical performance of a 1-bottle adhesive and resin composite system with a resin-modified glass ionomer restorative in non-carious cervical lesions....

  10. Performance Evolution of Various Wavelets in Cervical Lesion Detection

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    P S RAMAPRABA

    2014-01-01

    Full Text Available Cervical cancer is one of most common cancers among women in the world caused by human papilloma virus infection. It develops in the tissue of cervix which connects upper body of the uterus to the vagina. The types of cancer are squamous cell carcinoma, adeno carcinoma and adeno squamous carcinoma based on location of cervix where cancer develops. In this paper, an automatic detection of squamous cell carcinoma in cervical images based on Discrete Wavelet Transform (DWT and K-Nearest Neighbor (KNN classifier is described. The energy features are extracted from DWT decomposed image of small area of cervical images. Then the features are fed into KNN classifier to classify whether the given area is normal or cancer affected region. The performance of the proposed system is evaluated by using three wavelets namely bi-orthogonal (bior3.7, Daubechies-8(db8 and Symlet (sym8. Experimental results show the performance of db8 with other wavelets that produces 97.22% average accuracy.

  11. Relationship between hTERC gene and precancerous lesion as well as occurrence and development of cervical cancer

    Institute of Scientific and Technical Information of China (English)

    Li-Hong Yi

    2016-01-01

    Objective:To study the relationship betweenhTERC gene and precancerous lesion as well as occurrence and development of cervical cancer.Methods:A total of 120 cases receiving cervical biopsy in our hospital from May 2012 to December 2014 were selected for study, 45 cases of normal cervical tissue and inflammatory cervical tissue, 37 cases of cervical intraepithelial neoplasia tissue and 38 cases of cervical cancer tissue were included.hTERC gene expression, oncogene expression and invasive molecule contents in cervical tissue were detected.Results:Green signal copy number and red signal copy number ofhTERC in cervical cancer tissue were significantly higher than those in cervical intraepithelial neoplasia tissue and normal cervical tissue, and the contents of hTERTand hTP were not different from those in cervical intraepithelial neoplasia tissue and normal cervical tissue; the contents of proteins encoded by p63, TNFAIP8, SRX, P459arom and Piwil2 as well as the contents of RbAp48, Furin, MT1-MMP, TGF-β1, FoxM1, uPA and tPA in cervical cancer tissue were significantly higher than those in cervical intraepithelial neoplasia tissue and normal cervical tissue; the contents of proteins encoded by p63, TNFAIP8, SRX, P459arom and Piwil2 as well as the contents of RbAp48, Furin, MT1-MMP, TGF-β1, FoxM1, uPA and tPA in cervical cancer tissue with high expression of hTERC were significantly higher than those in cervical cancer tissue with low expression of hTERC.Conclusions:Activation of telomerase and increase of hTERC expression are involved in the precancerous lesion as well as the occurrence and development of cervical cancer, and hTERC can activate the expression of oncogenes and.

  12. Clinical application of a high-resolution positron emission tomography for cervical spinal cord lesions

    International Nuclear Information System (INIS)

    A high-resolution 18F-2-fluoro-deoxyglucose (FDG)-PET is possible in order for qualitative and quantitative estimation of impaired glucose metabolic activity of cervical spinal cord lesions. The imaging may be expected to offer some information on disturbed neuronal function in addition to the conventional MR imaging. (author)

  13. Prevalence of human papillomavirus DNA in female cervical lesions from Rio de Janeiro, Brazil

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    S. M. B. Cavalcanti

    1994-12-01

    Full Text Available A hundred-sixty paraffin-embedded specimens from female cervical lesions were examined for human papillomavirus (HPV types 6, 11, 16 and 18 infections by non-isotopic in situ hybridization. The data were compared with histologic diagnosis. Eighty-eight (55 biopsies contained HPV DNA sequences. In low grade cervical intraepithelial neoplasias (CIN I, HPV infection was detected in 78.7 of the cases, the benign HPV 6 was the most prevalent type. HPV DNA was detected in 58 of CIN II and CIN III cases and in 41.8 of squamous cell carcinomas (SCC. Histologically normal women presented 20 of HPV infection. Oncogenic HPV was found in 10 of these cases, what may indicate a higher risk of developing CINs and cancer. Twenty-five percent of the infected tissues contained mixed infections. HPV 16 was the most common type infecting the cervix and its prevalence raised significantly with the severity of the lesions, pointing its role in cancer pathogenesis. White women presented twice the cervical lesions of mulatto and African origin women, although HPV infection rates were nearly the same for the three groups (approximately 50. Our results showed that HPV typing by in situ hybridization is a useful tool for distinguishing between low and high risk cervical lesions. Further studies are required to elucidate risk factors associated with HPV infection and progression to malignancy in Brazilian population.

  14. One-year clinical evaluation of tooth-coloured materials in non-carious cervical lesions

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    Stojanac Igor

    2011-01-01

    Full Text Available Introduction. The restoration of non-carious cervical lesions is specific, mostly because of the location of their margins, especially the cervical margin, which is determined in cement and/or dentine. This feature makes the cervical margin more susceptible to micro-leak­age, causing marginal discoloration, postoperative sensitivity, development of the secondary caries and loss of the restoration. Material and methods. One of the criteria for inclusion of a patient in this study was the presence of at least two non-carious cervical lesions to be restored with the minimum depth of 1mm, independently of their location in the dental arch. A total of 60 restorations were placed in 30 patients, and every patient received both tested materials (composite resins and compomer on their non-carious cervical lesions. The clinical evaluation of the therapeutic success was performed six months and then one year after the day of the placement of restorations using the modified-United States Public Health Service criteria. The following was evaluated: retention, marginal integrity, marginal discoloration, wear, postoperative sensitivity and secondary caries. Results. A statistically significant high percent of restorations/teeth with postoperative sensitivity was found in the group of resin composite restorations after six months. At the end of the evaluation period, that is after one year, there were no statistically significant differences between materials for all evaluated criteria. Conclusion. The results of this study show the identical quality of both examined materials one year after the readjustment of non-carious cervical lesions.

  15. Distribution of Uterin Cervical Lesions and Relation Between Age and Parity Rates in the Mardin Province

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    Gülay AYDOĞDU

    2013-01-01

    Full Text Available Objective: The aim of this study is to evaluate the incidence and distribution of cervical lesions and compare characteristics such as parity and age of the women in Mardin province.Material and Method: Pap smears were drawn from the women screened at Mardin Gynecology and Pediatric Diseases Hospital from 2008 to 2011. All cervicovaginal smears were conventional Pap smear samples evaluated according to the 2001 Bethesda system.Results: There were 3.332 patients in total, whose smears showed no lesions in 3.125 patients. The mean age and number of parities of those patients were 37.34±11.25 and 4.78±3.28. There were 207 smears showing any lesions in cervix; ASC-US, ASC-H, LSIL, HSIL, AGC, squamous cell carcinoma and endocervical adenocarcinoma in 151 (72.94%; 16 (7.72%; 20 (9.66%; 8 (3.86%; 10 (4.83%; 1 (0.48% and 1 (0.48% patient, respectively. The mean age and the parities of the patients were 37.63±10.77 years and 4,74±2,92. Although there was no difference between the control and lesion groups, the parity and the age of patients who had ≥4 births in both the control and lesion groups were significantly higher than the patients with parities <4 births (p=0.000. There was no difference within the cervical lesion group comparing the ASC-US group with the total of the other lesions.Conclusion: High parity was one of the risk factor for having a lesion in uterine cervix in this population. This study represents an initial attempt to reflect the prevalence and the distribution of cervical lesions and their relation with the parity rates in the eastern regions in Turkey.

  16. Comparison of MRI pulse sequences for investigation of lesions of the cervical spinal cord

    International Nuclear Information System (INIS)

    Small spinal cord lesions, even if clinically significant, can be due to the low sensitivity of some pulse sequences. We compared T2-weighted fast (FSE), and conventional (CSE) spin-echo and short-tau inversion-recovery (STIR)-FSE overlooked on MRI sequences to evaluate their sensitivity to and specificity for lesions of different types. We compared the three sequences in MRI of 57 patients with cervical spinal symptoms. The image sets were assessed by two of us individually for final diagnosis, lesion detectability and image quality. Both readers arrived at the same final diagnoses with all sequences, differentiating four groups of patients. Group 1 (30 patients, 53 %), with a final diagnosis of multiple sclerosis (MS). Demyelinating lesions were better seen on STIR-FSE images, on which the number of lesions was significantly higher than on FSE, while the FSE and CSE images showed approximately equal numbers of lesions; additional lesions were found in 9 patients. The contrast-to-noise ratio (CNR) of 17 demyelinating lesions was significantly higher on STIR-FSE images than with the other sequences. Group 2, 19 patients (33 %) with cervical pain, 15 of whom had disc protrusion or herniation: herniated discs were equally well delineated with all sequences, with better myelographic effect on FSE. In five patients with intrinsic spinal cord abnormalities, the conspicuity and demarcation of the lesions were similar with STIR-FSE and FSE. Group 3, 4 patients (7 %) with acute myelopathy of unknown aetiology. In two patients, STIR-FSE gave better demarcation of lesions and in one a questionable additional lesions. Group 4, 4 patients (7 %) with miscellaneous final diagnoses. STIR-FSE had high sensitivity to demyelinating lesions, can be considered quite specific and should be included in spinal MRI for assessment of suspected demyelinating disease. (orig.)

  17. Comparison of MRI pulse sequences for investigation of lesions of the cervical spinal cord

    Energy Technology Data Exchange (ETDEWEB)

    Campi, A.; Pontesilli, S.; Gerevini, S.; Scotti, G. [San Raffaele Hospital, Milan (Italy). Dept. of Neuroradiology

    2000-09-01

    Small spinal cord lesions, even if clinically significant, can be due to the low sensitivity of some pulse sequences. We compared T2-weighted fast (FSE), and conventional (CSE) spin-echo and short-tau inversion-recovery (STIR)-FSE overlooked on MRI sequences to evaluate their sensitivity to and specificity for lesions of different types. We compared the three sequences in MRI of 57 patients with cervical spinal symptoms. The image sets were assessed by two of us individually for final diagnosis, lesion detectability and image quality. Both readers arrived at the same final diagnoses with all sequences, differentiating four groups of patients. Group 1 (30 patients, 53 %), with a final diagnosis of multiple sclerosis (MS). Demyelinating lesions were better seen on STIR-FSE images, on which the number of lesions was significantly higher than on FSE, while the FSE and CSE images showed approximately equal numbers of lesions; additional lesions were found in 9 patients. The contrast-to-noise ratio (CNR) of 17 demyelinating lesions was significantly higher on STIR-FSE images than with the other sequences. Group 2, 19 patients (33 %) with cervical pain, 15 of whom had disc protrusion or herniation: herniated discs were equally well delineated with all sequences, with better myelographic effect on FSE. In five patients with intrinsic spinal cord abnormalities, the conspicuity and demarcation of the lesions were similar with STIR-FSE and FSE. Group 3, 4 patients (7 %) with acute myelopathy of unknown aetiology. In two patients, STIR-FSE gave better demarcation of lesions and in one a questionable additional lesions. Group 4, 4 patients (7 %) with miscellaneous final diagnoses. STIR-FSE had high sensitivity to demyelinating lesions, can be considered quite specific and should be included in spinal MRI for assessment of suspected demyelinating disease. (orig.)

  18. Air Abrasion

    Science.gov (United States)

    ... delivered directly to your desktop! more... What Is Air Abrasion? Article Chapters What Is Air Abrasion? What Happens? The Pros and Cons Will I Feel Anything? Is Air Abrasion for Everyone? print full article print this ...

  19. The DNA load of six high-risk human papillomavirus types and its association with cervical lesions

    OpenAIRE

    Río Ospina, Luisa del; Soto de León, Sara; Camargo, Milena; Moreno Pérez, Darwin Andrés; Sánchez, Ricardo; Pérez Prados, Antonio; Patarroyo, Manuel Elkin; Patarroyo, Manuel Alfonso

    2015-01-01

    Background: Analysing human papillomavirus (HPV) viral load is important in determining the risk of developing cervical cancer (CC); most knowledge to date regarding HPV viral load and cervical lesions has been related to HPV-16. This study evaluated the association between the viral load of the six most prevalent high-risk viral types in Colombia and cervical intraepithelial neoplasia (CIN) frequency. Methods: 114 women without CIN and 59 women having CIN confirmed by colposcopy, all of them...

  20. Characterization of High Grade Intraepithelial Cervical Lesion among Adolescents and Young Women

    Directory of Open Access Journals (Sweden)

    Carlos Eric Daudinot Cos

    2011-11-01

    Full Text Available Introduction: considering the relationship between human papilomavirus and cervical cancer, the current increase in sexually transmitted diseases constitutes the biggest threaten to adolescents’ health. Objective: to characterize high-degree intraepithelial cervical lesion in adolescents and young women. Method: a descriptive and observational study was conducted. It included 52 patients, all of them younger than 24 years old, who had been diagnosed with high-degree cervical pathology and were treated in the cervix pathology consultation of the "Ramón González Coro" Teaching Gynecologic and Obstetric Hospital from January 2007 to December 2008. Risk factors and diagnosis variables were studied and processed using the SPSS 11.5 system for Windows, through the determination of absolute and relative frequencies. Results: 78,8 % of patients had from 20 to 24 years old, 65,3 % of them began having sexual relationships between 15 and 17 years old, 62,2 % had had 3 or more sexual partners and 67,3 % used no contraceptive method. Cyto- histological correlation was of 100 % for intraepithelial cervical lesion II and III. Conclusion: the results of the present study compromise us to highlight the need of extended sexual education among young people.

  1. Telomerase activity in high-grade cervical lesions is associated with allelic imbalance at 6Q14-22.

    NARCIS (Netherlands)

    Duin, van M.; Steenbergen, R.D.M.; Wilde, de J.; Helmerhorst, TJ; Verheijen, R.H.M.; Risse, E.K.J.; Meijer, C.J.L.M.; Snijders, P.J.F.

    2003-01-01

    Our study attempts to establish the relationship between telomerase activity and allelic imbalance (AI) on chromosomes 3p and 6 in high-risk HPV-containing cervical lesions. These chromosomes were implicated previously in telomerase regulation in HPV containing immortalized cells and cervical cancer

  2. Chondrocutaneous Branchial Remnants or Cartilaginous Choristoma: Terminology, Biological Behavior and Salience of Bilateral Cervical Lesions

    OpenAIRE

    Chander, Bal; Dogra, Sunder Singh; Raina, Rashmi; Sharma, Chanderdeep; Sharma, Renu

    2014-01-01

    Objective: To present and critically examine the spectrum of chondrocutaneous branchial remnants or accessory pinna, including rare case of bilateral cervical lesions, and to explain the basis of the biological behavior. Material and Method: Five cases of pediatric chondrocutaneous branchial remnants or accessory pinna were included. The ratios of the longest dimensions of the external ear to that of the accessory tragus/chondrocutaneous branchial remnants were calculated. Results: The...

  3. Osteosíntesis cervical posterior con placa en lesiones cervicales

    OpenAIRE

    Sánchez Martín, Miguel María

    2002-01-01

    El propósito del presente estudio es analizar retrospectivamente los resultados a largo plazo de las lesiones de la columna cervical baja tratadas mediante estabilización posterior con placas atornilladas de Roy-Cmille a las masas laterales. Pacientes y métodos: Se estudian 15 pacientes, de los cuales sólo 14 completos con lesiones traumáticas (13) y 1 no traumática (1 paciente con inestabilidad sobre artrosis por doble Cloward) durante un periodo postoperatorio medio de 8 años (6-12). Salvo ...

  4. Chondrocutaneous Branchial Remnants or Cartilaginous Choristoma: Terminology, Biological Behavior and Salience of Bilateral Cervical Lesions

    Directory of Open Access Journals (Sweden)

    Bal CHANDER

    2014-09-01

    Full Text Available Objective: To present and critically examine the spectrum of chondrocutaneous branchial remnants or accessory pinna, including rare case of bilateral cervical lesions, and to explain the basis of the biological behavior. Material and Method: Five cases of pediatric chondrocutaneous branchial remnants or accessory pinna were included. The ratios of the longest dimensions of the external ear to that of the accessory tragus/chondrocutaneous branchial remnants were calculated. Results: The size and rate of growth of chondrocutaneous branchial remnants or accessory pinna were found to be inversely proportional to the distance between the lesions and the normal pinna. Conclusion: The current literature and norms of terminology dictate that two different terminologies for lesions that are essentially histologically identical should be avoided. Chondrocutaneous branchial remnants, accessory pinna/tragus and chondroid/ cartilaginous choristomas are identical lesions with similar pathogeneses and should be referred to as choristomas.

  5. Genotype distribution of cervical human papillomavirus DNA in women with cervical lesions in Bioko, Equatorial Guinea

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    Carro-Campos Patricia

    2009-09-01

    Full Text Available Abstract Background The HVP vaccine is a useful tool for preventing cervical cancer. The purpose of this study is to determine the most frequent HPV genotypes in Equatorial Guinea in order to develop future vaccination strategies to apply in this country. Methods A campaign against cervical cancer was carried out in the area on a total of 1,680 women. 26 of the women, following cytological screening, were treated surgically with a loop electrosurgical excision procedure (LEEP. Cases were studied histologically and were genotyped from paraffin blocks by applying a commercial kit that recognized 35 HPV types. Results Cytological diagnoses included 17 HSIL, 1 LSIL, 5 ASC-H and 3 AGUS. Histological diagnosis resulted in 3 cases of microinvasive squamous cell carcinoma stage IA of FIGO, 9 CIN-3, 8 CIN-2, 2 CIN-1, 3 flat condylomas and mild dysplasia of the endocervical epithelium. Fifteen of twenty-five cases genotyped were positive for HPV (60%. HPV 16 and 33 were identified in four cases each, HPV 58 in two other cases, and HPV 18, 31, 52, and 82 in one case, with one HPV 16 and 58 coinfection. Conclusion The frequency of HPV types in the African area varies in comparison to other regions, particularly in Europe and USA. Vaccination against the five most common HPV types (16, 33, 58, 18, and 31 should be considered in the geographic region of West Africa and specifically in Equatorial Guinea.

  6. Ways of improving three-dimensional CT angiography images of cervical and cerebral vascular lesions

    International Nuclear Information System (INIS)

    We evaluated various ways of improving the image clarity of three-dimensional CT angiography (3D-CTA) for the diagnosis of cervical and cerebral vascular disease in sixty-seven patients (36 males and 31 females). The mean age was 61.4 years, with a rang of 17 to 89 years. The patients were examined with a helical CT scanner (TCT-X vision GX) after intravenous bolus injection of 90 ml nonionic contrast medium (300 mgI/ml) at the rate of 3 ml/sec. Intracranial and cervical 3D-CTA were performed 60 and 12 times, respectively. Our findings were as follows: Reduction of the pre-scanning delay time from 18 to 10 sec after the injection of the contrast medium eliminates much of the cavernous sinus from the image and makes it easier to distinguish the intracavernous internal carotid artery in intracranial 3D-CTA. In cervical 3D-CTA, reduction of the pre-scanning delay time from 15 to 9 sec delays imaging of the jugular vein and makes it easy to distinguish the bifurcation of the common carotid artery. A subtraction image on 3D-CTA is useful for detecting of vascular lesions adjacent to bone, such as lesions on the internal carotid artery. By producing a stereo picture, a closer three-dimensional relationship between the vascular lesion and the vessel circumference organization can be recognized. Vascular lesions can be clearly visualized from inside the artery using a 3D-CT endoscopic image. We were able to obtain a great deal of detailed information from 3D-CTA images with these modifications and we believe they enhance diagnostic accuracy of the technique. (author)

  7. One-year clinical evaluation of compomer restorations in cervical lesions of different aetiology

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    Premović Milica

    2012-01-01

    Full Text Available Introduction. The aim of this one-year prospective clinical study was to evaluate the treatment results of compomer restorations (Dyract® eXtra/ Dentsply/De Trey, Konstanz, Germany with a single step self-etching dental adhesive (Xeno® III Dentsply/De Trey, Konstanz, Germany used for restoring class V lesions (non-carious and primary carious cervical lesions. Material and Methods. A total number of 62 class V restorations (n = 62 were placed by one dentist in 30 patients on incisors, canines and premolars. The fillings were placed due to different indications: non-carious cervical defects (n = 32 and primary carious lesions (n = 30. The restorations were evaluated by a single-blind design, according to the Modified United States Public Health Service system 6 and 12 months following the placement. The following were evaluated: retention, marginal integrity, marginal discoloration, wear, postoperative sensitivity and secondary caries. The statistical analysis compared the ratings of each criteria between materials using the Pearson chi-square or Fisher’s exact test at a level of significance of 5% (p<0.05. Results. Two restorations of the non-carious lesion group were lost after 6 months, and after 12 months one restoration was lost in the group of primary carious lesions. There were no statistically significant differences between restorations for all evaluated criteria in both groups. Conclusion. The compomer restorations in combination with a single step self-etching dental adhesive showed acceptable clinical performance in Class V lesions after one year of clinical service.

  8. Prevalence of human papillomavirus types in cervical cancerous and precancerous lesions of Ecuadorian women.

    Science.gov (United States)

    Mejía, Lorena; Muñoz, Diana; Trueba, Gabriel; Tinoco, Leopoldo; Zapata, Sonia

    2016-01-01

    Human Papillomavirus (HPV) is the most common sexually transmitted infection worldwide and it is responsible for most cases of uterine cancer. In Ecuador there is limited information about HPV types (and variants) in cancerous lesions; however, identifying the type-specific HPV prevalence in cervical lesions of women living in Ecuador is important to better predict the impact of HPV prophylactic vaccination in this country. We studied the prevalence of HPV types in cervical cancerous or precancerous lesions from 164 Ecuadorian women and found that 86.0% were HPV positive. The most common types were HPV16 (41.8%) and HPV58 (30.5%). Interestingly, HPV18 was detected only in 2.8% of the HPV-positive samples. Fifteen DNA sequences (genes E6 and L1) from 16 samples positive for HPV16 belonged to the European lineage, considered one of the least carcinogenic lineages, and 1 (6.25%) to the Asian-American lineage. Similar analysis in 12 HPV58 positive samples showed that 10 (83.3%) sequences grouped in sublineage A2, which belongs to the oldest HPV58 lineage, 1 belonged to A3 and 1 to lineage C. This study suggests that the currently used HPV vaccines (bivalent and tetravalent) may have lower effectiveness in Ecuador than in other geographic locations where HPV18 is more prevalent. PMID:26113443

  9. Cervical intraepithelial lesions in females attending Women′s Health Clinics in Alexandria, Egypt

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    Mona Abdel-Hadi

    2015-01-01

    Full Text Available Background: Data from Egyptian studies provide widely varying estimates on the prevalence of preinvasive cervical lesions. The aim of this study was to estimate the rate of cervical intraepithelial neoplasia (CIN   in Egyptian women living in Alexandria to clarify the need for implementing a national organized screening program and a vaccination program in our community. Materials and Methods: The study was conducted over a 6 years period and covered the different socioeconomic levels to have a representative sample for women living in Alexandria. All women included did not have any cervical disorder related complaints. Conventional Pap smears were obtained and diagnosed using the Bethesda system. Women with abnormal Pap smears were managed according to the 2006 consensus guidelines within the available facilities. Persistent abnormal cytological results were referred for colposcopic biopsy. Histological results were grouped into: Reactive changes, CIN 1, CIN 2/CIN 3 and adenocarcinoma in-situ (AIS. Results: Out of the 6173 smears included in the study 6072 (98.36% were normal and only 101 (1.63% were abnormal. After colposcopic biopsies, 0.08% had CIN 1, 0.03% had CIN 2, 3 and 0.01% had AIS. Conclusion: We concluded that cervical cancer screening programs, although life-saving for a number of women, are not a sufficiently high priority in our community. Money for national health screening programs should preferably be directed more towards recruiting women for breast cancer screening, since breast cancer accounts for about 33% of all female cancers in Egypt ranking number one, while cervical cancer ranks number 13.

  10. EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR AND HUMAN PAPILLOMAVIRUS (HPV L1 CAPSID PROTEIN IN CERVICAL SQUAMOUS INTRAEPITHELIAL LESIONS

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    Balan Raluca

    2010-09-01

    Full Text Available We analyzed the immunohistochemical pattern of epidermal growth factor receptor (EGFR in cervical squamous intraepithelial lesions (SILs in correlation with L1 HPV capsid protein, in order to determine the relationship between EGFR expression and the infection status of human papillomavirus (HPV. The study included 40 cases, 24 LSIL (low grade SIL (CIN1, cervical intraepithelial neoplasia and 16 HSIL (high grade SIL (6 cases of CIN2 and 10 cases of CIN3. The immunoexpression of L1 HPV protein was assessed on conventional cervico-vaginal smears and EGFR was immunohistochemically evaluated on the corresponding cervical biopsies. The HPV L1 capsid protein was expressed in 45.83% of LSIL and 25% of HSIL. EGFR was overexpressed in 62,4% of HSIL (58,4% CIN2 and 41,6% CIN3 and 37,6% LSIL. The immunoexpression of L1 HPV has clinical application in the progression assessment of the cervical precancerous lesions without a correlation to the grade of the cervical SIL. EGFR is expressed by all proliferating squamous epithelial cells, thus corresponding with the grade of SIL. The evaluation of EGFR status, correlated with L1 HPV protein expression, can provide useful data of progression risk of cervical squamous intraepithelial lesions

  11. Space-occupying, inflammatory and dyplastic lesions of the cranio-cervical junction seen in nuclear magnetic resonance imaging (MRI)

    International Nuclear Information System (INIS)

    Lesions of the cranio-cervical junction have acquired a special place amongst lesions of the posterior cranial fossa and the upper cervical region. This is due to the unusually long period between the appearance of the first symptoms and reaching a conclusive diagnosis. Frequently such lesions cannot be detected by either normal X-rays or conventional tomographic techniques. The introduction, however, of computer tomography (CT) and, in particular, magnetic resonance imaging (MRI) has made the examination of the critical zone of the cranio-cervical junction much easier and the diagnosis of thee lesions has now become largely dependent upon those techniques. Because soft tissue contrast is intrinsic to MRI this technique, in particular, has made possible substantial improvements in the quality of images of ligaments and soft tissue than those provided by standard CT. In this paper, the advantages which are provided by MRI in the context of the diagnosis of non-bony lesions in the cranio-cervical region are presented and discussed

  12. Human Papillomavirus Genotyping and p16INK4a Expression in Cervical Lesions: A Combined Test to Avoid Cervical Cancer Progression

    Science.gov (United States)

    Zouheir, Yassine; Fechtali, Taoufiq; Elgnaoui, Nadia

    2016-01-01

    Cervical cancer is a major public health problem in Morocco. The cervical cancer has a long precancerous period that provides an opportunity for the screening and treatment. Improving screening tests is a priority goal for the early diagnosis of cervical cancer. This study was conducted to evaluate the combination of p16INK4a protein expression, human papillomavirus (HPV) typing, and histopathology for the identification of cervical lesions with high risk to progress to cervical cancer among Moroccan women. A total of 96 cervical biopsies were included in this study. Signal amplification in situ hybridization with biotinylated probes was used to detect HPV. Immunohistochemistry was used to evaluate the expression of p16INK4a protein. HPV DNA was detected in 74.0% of the biopsies (71/96). Of the seventy-one positive HPV cases, we detected 67.6% (48/71) of high risk (HR)-HPV (HPV 16 and 18), 24% of low risk-HPV (HPV 6 and 11), 1.4% intermediate risk-HPV (HPV 31, 33, and 35), and 7% coinfections (HPV 6/11 and 16/18). Overexpression of p16INK4a protein was observed in 72.9% (70/96) of the biopsies. In addition, p16INK4a protein detection was closely correlated with recovery of HR HPV. Our result showed that p16INK4a expression level is correlated with HR-HPV status. PMID:27390742

  13. Utility of Papanicolaou test in diagnosis of cervical lesions: a study in a tertiary care centre of western Uttar Pradesh

    Directory of Open Access Journals (Sweden)

    Mithila Bisht

    2015-05-01

    Full Text Available Background: Cervical cancer is the most common cancer among females in India. It is also one of the major causes of deaths among them. Papanicolaou (Pap cytological test helps in detecting the early epithelial abnormalities in cervical cells. The morbidity and mortality due to cervical cancer has come down in countries with well-established screening programmes at national level. This study was conducted to emphasize the value of cervical screening as a tool for early detection of non-neoplastic and neoplastic lesions of cervix. Slide positivity rate was computed and clinico-pathological correlation was done. Methods: This cross-sectional study was conducted from January 2012 to December 2014 (3 years, on 2202 women aged between 20-70 years coming for a Pap smear examination in a tertiary care hospital in Bareilly, India. After staining with conventional Papanicolaou technique, all cases were classified as per Bethesda nomenclature (2001. Results: Out of 2202 cases, 85.16% slides were found to be negative for intraepithelial abnormalities and 14.84% slides were labelled as positive for epithelial lesions. 97.67% of high grade lesions were found in women more than 40 years. Smears with epithelial cell abnormality were found more common in older age groups whereas smears negative for epithelial cell abnormality were found more common in young age groups. Conclusion: Pap test is a cost effective cancer screening and is a simple method to detect various lesions of cervix, non-neoplastic as well as neoplastic. High risk screening programmes should be directed to all women >40 years. Pap test is especially useful to diagnose precancerous lesions of cervix, thereby early detection of these lesions and subsequent proper treatment can be helpful in prevention of cervical cancer. [Int J Res Med Sci 2015; 3(5.000: 1070-1076

  14. Persistence of human papillomavirus DNA in cervical lesions after treatment with diathermic large loop excision.

    Science.gov (United States)

    Distéfano, A L; Picconi, M A; Alonio, L V; Dalbert, D; Mural, J; Bartt, O; Bazán, G; Cervantes, G; Lizano, M; Carrancá, A G; Teyssié, A

    1998-01-01

    OBJECTIVE: The aim of this study was to identify human papillomavirus (HPV) in cervical intraepithelial neoplasia (CIN) lesions and to evaluate the persistence of viral DNA after diathermic large loop excision (DLLE) treatment. STUDY DESIGN: Biopsies from 36 patients with low- and high-grade CIN lesions were studied before and after DLLE treatment looking for HPV sequences. DNA was extracted to perform a radioactive polymerase chain reaction (PCR) using GP 5,6 generic primers. PCR products were analyzed by the single-stranded conformational polymorphism (SSCP) which is a simultaneous detection and typing method. Dot-blot hybridization with generic and type-specific biotinylated oligonucleotide probes was applied in some cases. RESULTS: HPV DNA was found in all pretreatment samples, and the viral type was identified in 80% of them, HPV 16 being the most prevalent. The viral type coincided with that detected in the first biopsy in all except one case. Seventy five percent of the patients (27 cases) were negative for CIN at follow up, but 50% of them remained HPV DNA positive. CONCLUSION: DLLE treatment was effective in removing the CIN lesion but not the HPV. This fact points out the need to asses the presence of HPV in DNA during the follow-up, since viral persistence has been considered a high risk factor for recurrence and/or malignant transformation. PMID:9894176

  15. CT-diagnosis for mass lesions in the parotid gland and cervical region

    International Nuclear Information System (INIS)

    Thirty patients suffering from mass lesion in the parotid gland or cervical region were examined by computed tomography (CT). The photographed images were compared with the findings and pathological diagnoses obtained by surgical procedures. The conclusions were as follows: 1) Plain CT demonstrated the location of the parotid tumor. Contrast enhancement seemed to delineate the margin of the tumor more clearly. 2) By contrast enhancement, the branchiogenic cyst was differentiated from the parotid tumor, as a low density mass with an enhanced cyst wall. 3) Parotid tumors enhanced by contrast material did not always appear as solid tumors. 4) In some cases, CT numbers indicated the contents of the tumor. 5) The extension of the tumor to the parapharyngeal space was clearly depicted on CT. 6) It seemed to be difficult to evaluate the relationship of the parotid tumor to the facial nerve on plain CT. (author)

  16. Motor Deficit After Cervical Surgery, Parsonage-Turner Syndrome or Root Lesion

    Directory of Open Access Journals (Sweden)

    Ayse Sarifakioglu

    2013-06-01

    Full Text Available A 60 years old male patient was admitted to our outpatient clinic with the complaint of severe pain in right arm after cervical stenosis surgery which had been decreased with the formation of progressive motor weakness. Although clinical and physical evaluation was compatable with Parsonage-Turner syndrome (PTS, C5 root involvement has been detected. The patient was given exercise therapy with TENS for analgesia. The patient%u2019s motor weakness progressed and he had difficulties with daily living activities. With the review of literature, we are presenting a case, whose diagnosis was difficult in terms of differentiating both PTS and root lesion which could only be diagnosed by electroneuromyography.

  17. Urgent stenting for patients with acute stroke due to atherosclerotic occlusive lesions of the cervical internal carotid artery

    International Nuclear Information System (INIS)

    Acute symptomatic occlusion of the cervical internal carotid artery (ICA) can be treated by intravenous administration of tissue plasminogen activator, percutaneous transluminal angioplasty, and carotid endarterectomy. Carotid artery stenting (CAS) is now indicated for cervical ICA stenosis, but the safety and the efficacy of urgent CAS have not been established. We retrospectively reviewed 10 patients treated by urgent CAS for atherosclerotic occlusive lesions of cervical ICA with acute stroke. Five patients had complete occlusions and five had near total occlusions. Five of the 10 patients had intracranial tandem occlusions. Indication for urgent CAS was determined by mismatch of diffusion-weighted and perfusion-weighted magnetic resonance imaging findings. Stents were successfully deployed in all lesions. Three of five patients with concomitant intracranial tandem occlusions were treated by additional intraarterial fibrinolysis after the CAS. Intracranial artery occlusions were completely recanalized in one patient, and partially recanalized in two by fibrinolysis. Hyperperfusion syndrome did not occur in any of the patients. A favorable outcome (modified Rankin Scale ≤1) was obtained in all of the five patients with isolated cervical ICA occlusion and one of the five patients with intracranial tandem occlusions. Urgent CAS is a safe and effective treatment in patients with isolated cervical ICA occlusion. Treatment of intracranial tandem occlusions is an issue that must be resolved. (author)

  18. Pattern of cervical lesions, with emphasis on precancer and cancer in a tertiary care hospital of Southern India

    Directory of Open Access Journals (Sweden)

    Nagamani Gumpeny

    2015-05-01

    Full Text Available Background: Carcinoma cervix is the most common form of cancer in India. Screening is cost-effective but compliance is an issue. Most women present to hospitals at first visit. We studied the pattern of women with carcinoma cervix who presented to the gynecology outpatient department of a large hospital in southern India. Methods: Women attending the gynecology outpatient department of King George hospital were evaluated for the presence of cervical lesions. A complete history was obtained. Biopsies from the cervix were obtained from the aceto-white areas, fixed in 10% buffered neutral formalin. Results: 860 cervical biopsy specimens were received. By routine hematoxylin eosin stains, 180 had precancerous lesions and cancerous lesions with more than two risk factors; in the study period, a total of 253 cervical neoplasms were recorded: 103 were in the pre-cancerous stage (CINU1: 74; 71.84%, CIN II 20/103; 19.41%, CIN III 9/103; 8.73%. Of the 150 cancerous lesions, maximum were SCC non-keratinising (130; 92%. A subset (viz 45/180; 25% were tested for HPV DNA using Polymerase Cycle Reaction (PCR. The commonest presenting symptom was leucorrhea (40%. Most women reported age of first intercourse below 30 years. On visual examination of cervix, most (25; 55.55% had exophytic growth and erosion (14; 31.11%. More than 80% (n: 24 presented in stage II and III cancer (n:27. Conclusion: In this hospital based study from a large institution from Southern India, out of 860 cervical biopsy specimens studied, 180 (32.14% had precancerous lesions and cancerous lesions with more than two risk factors. [Int J Res Med Sci 2015; 3(5.000: 1122-1124

  19. Increase of Integration Events and Infection Loads of Human Papillomavirus Type 52 with Lesion Severity from Low-Grade Cervical Lesion to Invasive Cancer▿

    OpenAIRE

    Cheung, Jo L. K.; Cheung, T. H.; Tang, Julian W. T.; Chan, Paul K. S.

    2008-01-01

    Infection load and the integration of human papillomaviruses (HPV) have been implicated as determinants for oncogenesis, but whether variation among different HPV types exists remains unclear. We investigated 91 women infected with HPV type 52 (HPV-52), a type that is rare worldwide but common in East Asia. The median viral load increased with the severity of the lesion (248 copies/cell equivalent for normal/cervical intraepithelial neoplasia [CIN] grade 1, 402 copies/cell equivalent for CIN ...

  20. Corneal Abrasions

    Science.gov (United States)

    ... eye under a light that is filtered cobalt blue. The fluorescein causes the abrasion to glow bright ... putting in or removing your contacts. Around the house, be extra careful when you use cleaning products, ...

  1. Associated factors with cervical pre-malignant lesions among the married fisher women community at Sadras, Tamil Nadu

    Directory of Open Access Journals (Sweden)

    Sornam Ganesan

    2015-01-01

    Full Text Available Objective: To identify the associated factors of cervical pre-malignant lesions among the married fisher women residing in the coastal areas of Sadras, Tamil Nadu. Methods: The study was conducted in five fishermen communities under Sadras, a coastal area in Tamil Nadu, India. Two hundred and fifty married fisher women residing in the area. Quantitative descriptive approach with a cross-sectional study design was used. Data were collected using a structured interview schedule for identifying the associated factors and Pap smear test was performed for identifying the pre-malignant cervical lesions among the married fisher women. Data were analyzed using descriptive and inferential statistics. Results: Among 250 women, about six (2.4% of them presented with pre-cancerous lesions such as atypical squamous cell of undifferentiated significance (ASCUS - five (2% and mild dysplasia one (0.4%. Majority of the women, about 178 (71.2% women, had abnormal cervical findings. Statistical analysis showed a significant association of risk factors such as advanced age, lack of education, low socioeconomic status, using tobacco, multiparity, premarital sex, extramarital relationship, using cloth as sanitary napkin, etc. Conclusion: The study findings clearly show the increased vulnerable state of the fisher women for acquiring cervical cancer as they had many risk factors contributing to the same.

  2. Incidence of cervical lesions in Danish women before and after implementation of a national HPV vaccination program

    DEFF Research Database (Denmark)

    Baldur-Felskov, Birgitte; Dehlendorff, Christian; Junge, Jette;

    2014-01-01

    PURPOSE: Approximately 7% of cervical cancers and about 50% of high-grade cervical precursor lesions are caused by human papillomavirus (HPV) types 16 and 18. Denmark introduced the quadrivalent HPV vaccine into the vaccination program for 12-year-old girls in 2009 supplemented by a first catch......+) and cervical intraepithelial neoplasia grade 2 or worse (CIN2+) increased in all age groups in 2000-2010. After introduction of the quadrivalent HPV vaccine into the vaccination program, the incidence of atypia+ decreased significantly in women younger than 18 years (EAPC -33.4%; 95% CI -49.6; -12.0) and in 18...... in age groups with high HPV vaccine coverage, indicating an early effect of HPV vaccination....

  3. Characterization of High Grade Intraepithelial Cervical Lesion among Adolescents and Young Women Caracterización de las lesiones intra-epiteliales cervicales de alto grado en adolescentes y mujeres jóvenes

    OpenAIRE

    Carlos Eric Daudinot Cos; Albania Rodríguez Spinola; Viviana de la Caridad Sáez Cantero; Ana Isabel de la Torre Jiménez

    2011-01-01

    Introduction: considering the relationship between human papilomavirus and cervical cancer, the current increase in sexually transmitted diseases constitutes the biggest threaten to adolescents’ health. Objective: to characterize high-degree intraepithelial cervical lesion in adolescents and young women. Method: a descriptive and observational study was conducted. It included 52 patients, all of them younge...

  4. A pooled analysis of continued prophylactic efficacy of quadrivalent human papillomavirus (Types 6/11/16/18) vaccine against high-grade cervical and external genital lesions

    DEFF Research Database (Denmark)

    Kjaer, Susanne K; Sigurdsson, Kristján; Iversen, Ole-Erik;

    2009-01-01

    Quadrivalent human papillomavirus (HPV) vaccine has been shown to provide protection from HPV 6/11/16/18-related cervical, vaginal, and vulvar disease through 3 years. We provide an update on the efficacy of the quadrivalent HPV vaccine against high-grade cervical, vaginal, and vulvar lesions bas...

  5. Prevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania.

    Science.gov (United States)

    Liu, Enju; McCree, Renicha; Mtisi, Expeditho; Fawzi, Wafaie W; Aris, Eric; Lema, Irene A; Hertzmark, Ellen; Chalamilla, Guerino; Li, Nan; Vermund, Sten H; Spiegelman, Donna

    2016-03-01

    To determine the prevalence and predictors of cervical squamous intraepithelial lesions (SIL) among HIV-infected women in Tanzania, a cross-sectional study was conducted among HIV-infected women at HIV care and treatment clinics. A Papanicolaou (Pap) smear was used as a screening tool for detection of cervical SIL. From December 2006 to August 2009, 1365 HIV-infected women received cervical screening. The median age was 35 (interquartile range [IQR]: 30-42) years, and the median CD4 + cell count was 164 (IQR: 80-257) cells/mm(3). The prevalence of cervical SIL was 8.7% (119/1365). In multivariate analysis, older age (≥50 versus 30-<40 years: prevalence ratio [PR], 2.36; 95% confidence interval [CI], 1.45-3.84, p for trend = 0.001), lower CD4 + cell counts (<100 versus ≥200 cells/mm(3): PR, 1.55; 95% CI, 1.01-2.36, p for trend = 0.03) and cervical inflammation (PR, 1.73; 95% CI, 1.16-2.60, p = 0.008) were associated with an increased risk of cervical SIL. Women with advanced WHO HIV disease stage (IV versus I/II: PR, 3.45; 95% CI, 1.35-8.85, p for trend = 0.01) had an increased risk for high-grade SIL. In resource-limited settings where it is not feasible to provide cervical cancer prevention services to all HIV-infected women, greater efforts should focus on scaling-up services among those who are older than 50 years, with lower CD4 cell counts and advanced HIV disease stage. PMID:25957324

  6. Restoration of non-carious cervical lesions with ceramic inlays: A possible model for clinical testing of adhesive cements

    OpenAIRE

    Michal Staninec; Tsuji, Grant H.

    2012-01-01

    Introduction: There are many luting cements coming to market which claim to be adhesive, but there is no clinical protocol currently for testing these claims. There is a standardized protocol for testing direct restorations bonded to dentin and it is used extensively. Case Report: We describe a clinical procedure for restoring a non-carious cervical lesion (NCCL) with a ceramic inlay using Computer-Aided Design and Computer-Aided Manufacturing (CAD-CAM) technology and an adhesive resin cement...

  7. CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study

    Science.gov (United States)

    dos Santos, Erinaldo Ubirajara Damasceno; de Lima, Géssica Dayane Cordeiro; Oliveira, Micheline de Lucena; Heráclio, Sandra de Andrade; da Silva, Hildson Dornelas Angelo; Crovella, Sergio; Maia, Maria de Mascena Diniz; de Souza/, Paulo Roberto Eleutério

    2016-01-01

    Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) andCCR5-Δ32 (rs333) polymorphisms with susceptibility to develop cervical lesion (CIN and CC) in a Brazilian population. The genotyping of 139 women with cervical lesions and 151 women without cervical lesions for the CCR2-64I and CCR5-Δ32 polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism. The individuals carrying heterozygous or homozygous genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk for cervical lesion [odds ratio (OR) = 0.37, p = 0.0008)]. The same was observed for the A allele (OR = 0.39, p = 0.0002), while no association was detected (p > 0.05) with CCR5-Δ32 polymorphism. Regarding the human papillomavirus (HPV) type, patients carrying the CCR2-64Ipolymorphism were protected against infection by HPV type 16 (OR = 0.35, p = 0.0184). In summary, our study showed a protective effect ofCCR2-64I rs1799864 polymorphism against the development of cervical lesions (CIN and CC) and in the susceptibility of HPV 16 infection. PMID:26982176

  8. Immunohistochemical Expression of VEGF and Podoplanin in Uterine Cervical Squamous Intraepithelial Lesions

    Science.gov (United States)

    Belfort-Mattos, Patrícia Napoli; Focchi, Gustavo Rubino de Azevedo; Ribalta, Julisa Chamorro Lascasas; Megale De Lima, Tatiana; Nogueira Carvalho, Carmen Regina; Kesselring Tso, Fernanda; De Góis Speck, Neila Maria

    2016-01-01

    VEGF and podoplanin (PDPN) have been identified as angiogenesis and/or lymphangiogenesis regulators and might be essential to restrict tumor growth, progression, and metastasis. In the present study, we evaluate the association between the expression of these markers and CIN grade. Immunohistochemistry was performed in 234 uterine cervical samples using conventional histologic sections or TMA with the monoclonal antibodies to VEGF (C-1 clone) and podoplanin (D2-40 clone). Positive-staining rates of VEGF in 191 CIN specimens were significantly associated with histological grade (P < 0.001). Negative and/or focal immunostaining for PDPN were more frequent in CIN 3 (P = 0.016). We found that patients with CIN 3 more frequently had strong and more diffuse staining for VEGF and diminished staining for PDPN (P = 0.018). Strong and more diffuse VEGF immunoexpressions in CIN 2 and CIN 3 were detected when compared to CIN 1. Negative and/or focal PDPN immunoexpression appear to be more frequent in CIN 3. Moderate to strong VEGF expression may be a tendency among patients with high-grade lesions and diminished PDPN expression. PMID:27313335

  9. Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients.

    Science.gov (United States)

    Kim, Tae Jin; Jin, Hyun-Tak; Hur, Soo-Young; Yang, Hyun Gul; Seo, Yong Bok; Hong, Sung Ran; Lee, Chang-Woo; Kim, Suhyeon; Woo, Jung-Won; Park, Ki Seok; Hwang, Youn-Young; Park, Jaehan; Lee, In-Ho; Lim, Kyung-Taek; Lee, Ki-Heon; Jeong, Mi Seon; Surh, Charles D; Suh, You Suk; Park, Jong Sup; Sung, Young Chul

    2014-01-01

    Here, we demonstrate that electroporation-enhanced immunization with a rationally designed HPV DNA vaccine (GX-188E), preferentially targeting HPV antigens to dendritic cells, elicits a significant E6/E7-specific IFN-γ-producing T-cell response in all nine cervical intraepithelial neoplasia 3 (CIN3) patients. Importantly, eight out of nine patients exhibit an enhanced polyfunctional HPV-specific CD8 T-cell response as shown by an increase in cytolytic activity, proliferative capacity and secretion of effector molecules. Notably, seven out of nine patients display complete regression of their lesions and viral clearance within 36 weeks of follow up. GX-188E administration does not elicit serious vaccine-associated adverse events at all administered doses. These findings indicate that the magnitude of systemic polyfunctional CD8 T-cell response is the main contributing factor for histological, cytological and virological responses, providing valuable insights into the design of therapeutic vaccines for effectively treating persistent infections and cancers in humans. PMID:25354725

  10. Cervical Lesions in Women Younger than 25 Years Lesiones de cuello uterino en mujeres menores de 25 años

    Directory of Open Access Journals (Sweden)

    Yoleisi Alonso Fleites

    2011-12-01

    Full Text Available

    Background: Cervical cancer is essentially a sexually transmitted disease related to human papillomavirus infection. This disease’s incidence has been globally enhanced, particularly in increasingly younger women. Objective: To determine cervical lesions in women younger than 25 years. Methods: An observational, descriptive and correlational study including 248 patients registered at the Pathological Anatomy Service of the General University Hospital Dr. Gustavo Aldereguía Lima of Cienfuegos was conducted from January to December 2007. It also included the first quarter of 2008. The following variables were analyzed: patient’s age, age at first intercourse, number of sexual partners, type and degree of injury, and reason for attending consultation. Results: Women over 21 years old and those who had had 2 and 3 sexual partners predominated. The main reason for attending consultation was cervicitis (84, 7%. In 22.6% of women grade I intraepithelial neoplasia was detected, while grade II and III were detected in 41, 9% and 33, 1%, respectively. In 90% of younger patients the lesion was malignant. Conclusions: The presence of cervical lesions in women under 25 years is not low and neither is the frequency of malignant lesions.

    Fundamento: el cáncer cervical es esencialmente una enfermedad de transmisión sexual relacionada con la infección por el virus del papiloma humano. Este fenómeno ha aumentado globalmente, en especial en mujeres cada vez más jóvenes. Objetivo: determinar las lesiones de cuello uterino en mujeres menores de 25 años. Métodos: estudio observacional, descriptivo y correlacional que incluyó 248 pacientes registradas en el Servicio de Anatomía Patológica del Hospital General Universitario Dr. Gustavo Aldereguía Lima de Cienfuegos, en el periodo de enero a

  11. TCT联合HPV检测在宫颈病变筛查中的意义%Cervical Liquid-Based Cytology Combined Human Papillomavirus Testing in Cervical Lesion

    Institute of Scientific and Technical Information of China (English)

    戴一菲; 田荣华

    2012-01-01

    Objective To study the significance of combination of cervical liquid-based cytology and human papillomavirus detection in cervical lesion screening. Methods From March 2010 to December 2011,3,028 patients were detected with nipple shaped tumor virus ( HPV) and cervical liquid base cytology (TCT) ,TCT was used by 2001 International Cancer Association TBS diagnosis system report way,to the patients with positive results of TCT check for ASCIIS and the above lesions and (or) HPV detection, cervical organization biopsy under electronic vaginal mirror were performed. Results The sensitivity of TCT check was 56.72% ,with the specificity of 28. 19% ;the sensitivity of HPV check was 86.03% ,with specific for 46.38% ;among 408 cases of CIN and cervical cancer pathology ,28 cases were single TCT positive (6. 86% ) ;with TCT and HPV positive 203 ca-ses(49. 75% ) ,there was significant difference in diagnosis of cervical squamous intraepithelial neoplasm ( CIN) and cervical cancer(x2 = 184.926,P=0.000) between single TCT check and combination of TCT and HPV examination. Conclusion TCT combined with HPV check can improve the detection rate of cervical cancer and precancerous lesions, improve the sensitivity and specificity of screening,effectively reduce the TCT in detection of false-negative rates,and avoid excessive colposcopy and biopsy in low-risk populations and over-treatment.%目的 探讨宫颈液基细胞学检查与人乳头状瘤病毒检测联合应用在宫颈病变筛查中的意义.方法 选取2010年3月-2011年12月孝感市中心医院病理科同时进行了宫颈液基细胞学(TCT)检查及人乳头状瘤病毒(HPV)检测的患者3028人,TCT采用2001年国际癌症协会TBS诊断系统报告方式,对TCT检查结果为ASCUS及以上病变和(或)HPV检测结果为阳性的患者在电子阴道镜下取宫颈组织活检.结果 TCT检查敏感度为56.72%,特异度为28.19%;HPV检查敏感度为86.03%,特异度为46.38%;病

  12. DAPK1, MGMT and RARB promoter methylation as biomarkers for high-grade cervical lesions

    OpenAIRE

    Sun, Yin; Li, Shu; Shen, Keng; Ye, Shuang; Cao, Dongyan; Yang, Jiaxin

    2015-01-01

    Gene promoter methylation may be used a potential biomarker for detecting solid tumor including cervical cancer. Here, we used methylation sensitive-high resolution melting (MS-HRM) analysis to detecting promoter methylation ratios of DAPK1, MGMT and RARB gene in patients with different cervical disease grade. The detection of gene promoter methylation was conducted in two hundred fifty patients’ samples including normal cytology (n=48), cervical intraepithelial neoplasia grade 1 (CIN1, n=54)...

  13. DAPK1, MGMT and RARB promoter methylation as biomarkers for high-grade cervical lesions

    Science.gov (United States)

    Sun, Yin; Li, Shu; Shen, Keng; Ye, Shuang; Cao, Dongyan; Yang, Jiaxin

    2015-01-01

    Gene promoter methylation may be used a potential biomarker for detecting solid tumor including cervical cancer. Here, we used methylation sensitive-high resolution melting (MS-HRM) analysis to detecting promoter methylation ratios of DAPK1, MGMT and RARB gene in patients with different cervical disease grade. The detection of gene promoter methylation was conducted in two hundred fifty patients’ samples including normal cytology (n=48), cervical intraepithelial neoplasia grade 1 (CIN1, n=54), cervical intraepithelial neoplasia grade 2 (CIN2, n=47), cervical intraepithelial neoplasia grade 3 (CIN3, n=56) and cervical squamous cell carcinomas (SCS, n=45). We found there were a significant positive correlation between the promoter methylation status of DAPK1 and cervical disease grade (P=0.022). In addition, the methylated promoters of DAPK1 combined with MGMT, MGMT combined with RARB, DAPK1 combined with RARB were positive correlated with cervical disease grade (P < 0.05). All three genes promoters methylated were positive correlated with cervical disease grade (P < 0.001). Receiver operating characteristic (ROC) curves was conducted to evaluate whether the three genes methylation could be used to be a potential marker for diagnosing high grade cervical disease (HSIL and SCC). The cutoff values for the methylation rates of all these genes were 0-5%. Regrettably, only the methylation of MGMT combined with DAPK1 gave 43.4% sensitivity and 68.6% specificity. The current results indicated that MS-HRM-based testing for DNA methylations of MGMT plus DAPK1 genes holds some promise for high grade cervical disease screening. PMID:26823825

  14. Randomized clinical trial of four adhesion strategies in cervical lesions: 12-month results.

    Science.gov (United States)

    de Paula, Eloisa Andrade; Tay, Lidia Yileng; Kose, Carlos; Mena-Serrano, Alexandra; Reis, Alessandra; Perdigão, Jorge; Loguercio, Alessandro D

    2015-01-01

    The aim of this study was to evaluate the 6- and 12-month clinical performance of four adhesion strategies from the same manufacturer (Kerr) in non-carious cervical lesions (NCCLs) using two evaluation criteria. Thirty-five patients, with at least four NCCLs each, participated in this study. After samplesize calculation, 180 restorations were assigned to one of the following groups: OFL (Optibond FL), OSP (Optibond Solo Plus), XTR (Optibond XTR), and AIO (Optibond All-In-One). The composite resin Filtek Supreme Ultra (3M ESPE) was placed incrementally. The restorations were evaluated at baseline, after 6 months, and after 12 months, using both the FDI and the USPHS-modified criteria. Statistical analyses were performed with Friedman repeated measures, ANOVA by rank, and the McNemar test for significance in each pair (α=0.05). Six restorations (2 for OFL, 1 for OSP, 2 for XTR, and 1 for AIO) were lost at 12 months (P>0.05 for both evaluation criteria). Marginal staining was observed in seven restorations using the FDI criteria (P>0.05) and three restorations using the USPHSmodified criteria (P>0.05). Eight restorations (2 for OSP, 3 for XTR, and 3 for AIO) were classified as Bravo for marginal adaptation using the USPHSmodified criteria (P>0.05). However, 62 restorations (14 for OFL, 12 for OSP, 15 for XTR, and 21 for AIO) were classified as Bravo using the FDI criteria (P>0.05). The four adhesion strategies showed similar clinical retention at 6 and 12 months. The FDI evaluation criteria tend to be more sensitive than the USPHS-modified criteria. PMID:25625130

  15. Clinical and epidemiological correlations between the infection with HPV 16 and HPV 18 and female cervical lesions.

    Science.gov (United States)

    Stoian, M; Repanovici, R; Corniţescu, F

    1995-01-01

    A number of 66 specimens from female cervical lesions were examined for infection with human papillomavirus (HPV) types 6, 11, 16, and 18 by nucleic acid hybridization in dot-blot techniques and 35 sera were tested by the immunodot-blot technique, in order to detect the presence of anti E4 and E7 HPV protein antibodies. The findings were compared with the histologic diagnosis. Fifty-six per cent of specimens contained HPV DNA sequences. In 47% of specimens from cervical carcinoma, HPV 11 was detected in 4 cases, HPV 16 in 21 cases, and HPV 18 in 7 cases. Serum antibodies against HPV 16 E4 and HPV 16 E7 occurred in all the cases of uterine carcinoma, in 4 of 10 cases of CIN I-II, and in 3 of 5 sera obtained from apparently healthy women. The analysis of risk factors disclosed the early onset of sexual activity, a relatively high number of births and abortions before the age of 22 years, the use of oral oestroprogestative contraceptive agents, the presence in anamnesis of genital infections with bacterial flora--Candida albicans, Trichomonas vaginalis, Chlamydia trachomatis, Mycoplasma, etc. Our results showed that HPV typing by nucleic acid hybridization was useful for differentiating low- from high-risk cervical lesions and also tried to elucidate the risk factors associated with HPV infections and progression to malignancy. PMID:9179967

  16. Methylation and expression of miRNAs in precancerous lesions and cervical cancer with HPV16 infection.

    Science.gov (United States)

    Jiménez-Wences, Hilda; Martínez-Carrillo, Dinorah Nashely; Peralta-Zaragoza, Oscar; Campos-Viguri, Gabriela Elizabeth; Hernández-Sotelo, Daniel; Jiménez-López, Marco Antonio; Muñoz-Camacho, José Guadalupe; Garzón-Barrientos, Víctor Hugo; Illades-Aguiar, Berenice; Fernández-Tilapa, Gloria

    2016-04-01

    Abnormal expression and promoter methylation of microRNAs (miRNAs) are common events during cervical carcinogenesis. Worldwide, infection by types 18 and 16 of human papillomaviruses (HPVs) is considered the major risk factor for cervical cancer development. It has been reported that expression of the miRNAs can be deregulated by specific HPV genotypes. In this study we analyzed the promoter methylation of 22 miRNAs and the expression of three miRNAs in 10 non-squamous intraepithelial lesions (Non-SIL) without HPV16 infection, and 7 Non-SIL, 16 low-grade SIL (LSIL) and 16 cervical cancer samples, all with HPV16 infection. The methylation status was determined using Human Cancer miRNA EpiTect Methyl II Signature PCR Array® and the expression of miR-124, miR-218 and miR-193b was determined by qRT-PCR using individual TaqMan assays. Comparisons of groups defined were performed using the Fisher exact test for categorical variables and Mann-Whitney test for continuous variables. A p-value of <0.05 was considered statistically significant. The methylation levels of miR-124-2, miR-218-1, miR-218-2 and miR-34b/c promoters were significantly higher in cervical cancer than in LSIL samples. The methylation levels of miR-193b promoter were significantly lower in cervical cancer than in LSIL samples. The expression of miR-124 and miR-218 was significantly lower in cervical cancer than in LSIL samples. The expression of miR-193b was significantly higher in cervical cancer than in LSIL and Non-SIL samples. Our results suggest that the abnormal promoter methylation and expression of miR-124, miR-218 and miR-193b are common events during cervical carcinogenesis. PMID:26797462

  17. Quadrivalent HPV vaccine effectiveness against high-grade cervical lesions by age at vaccination: A population-based study.

    Science.gov (United States)

    Herweijer, Eva; Sundström, Karin; Ploner, Alexander; Uhnoo, Ingrid; Sparén, Pär; Arnheim-Dahlström, Lisen

    2016-06-15

    Human papillomavirus (HPV) types 16/18, included in HPV vaccines, contribute to the majority of cervical cancer, and a substantial proportion of cervical intraepithelial neoplasia (CIN) grades 2/3 or worse (CIN2+/CIN3+) including adenocarcinoma in situ or worse. The aim of this study was to quantify the effect of quadrivalent HPV (qHPV) vaccination on incidence of CIN2+ and CIN3+. A nationwide cohort of girls and young women resident in Sweden 2006-2013 and aged 13-29 (n = 1,333,691) was followed for vaccination and histologically confirmed high-grade cervical lesions. Data were collected using the Swedish nationwide healthcare registers. Poisson regression was used to calculate incidence rate ratios (IRRs) and vaccine effectiveness [(1-IRR)x100%] comparing fully vaccinated with unvaccinated individuals. IRRs were adjusted for attained age and parental education, and stratified on vaccination initiation age. Effectiveness against CIN2+ was 75% (IRR = 0.25, 95%CI = 0.18-0.35) for those initiating vaccination before age 17, and 46% (IRR = 0.54, 95%CI = 0.46-0.64) and 22% (IRR = 0.78, 95%CI = 0.65-0.93) for those initiating vaccination at ages 17-19, and at ages 20-29, respectively. Vaccine effectiveness against CIN3+ was similar to vaccine effectiveness against CIN2+. Results were robust for both women participating to the organized screening program and for women at prescreening ages. We show high effectiveness of qHPV vaccination on CIN2+ and CIN3+ lesions, with greater effectiveness observed in girls younger at vaccination initiation. Continued monitoring of impact of HPV vaccination in the population is needed in order to evaluate both long-term vaccine effectiveness and to evaluate whether the vaccination program achieves anticipated effects in prevention of invasive cervical cancer. PMID:26856527

  18. Expression of bcl-2 marker in premalignant lesions of cervical cancer

    OpenAIRE

    Shreedevi Kamaraddi; Ashwini Nayak U.; Shridhar Honnappa; Asha Swarup

    2016-01-01

    Background: Cervical cancer is one of the most common gynecological cancers in women of developing countries. HPV DNA testing is preferred cervical screening method for woman 30-65 years old as HPV is the proved causative agent of cervical carcinoma. Due to the high costs involved in doing HPV DNA test there is a need for a biomarker such as Bcl-2 which can indicate the initiation of carcinogenic process of HPV infection and thus can be used to identify those woman who will need more surveill...

  19. Cervical myelopathy due to single level disc herniation presenting as intramedullary mass lesion: What to do first?

    Directory of Open Access Journals (Sweden)

    Murat Sakir Eksi

    2015-01-01

    Full Text Available Cervical myelopathy (CM is mostly a degenerative process ending in myelopathic and/or radiculopathic syndromes. On T2-weighted magnetic resonance imaging (MRI, CM appears as a hyperintense area near the spondylotic spine. This high intensity signal depends on the impact of outer forces and their duration. It also determines the prognosis of the surgical candidate. A 40-year-old male patient admitted to our clinic with right upper extremity weakness and hypoesthesia that had started 2 months earlier. On neurological examination there was 2/5 motor weakness of right biceps brachii, and hypoesthesia over right C6 dermatome. Right upper extremity deep tendon reflexes were hypoactive, but lower ones were hyperactive. After clinical and radiological work-up, preliminary diagnosis was directed to a spinal intramedullary tumor. Total resection of the herniated cervical disc fragment and the mass lesion was managed. Pathology of the mass lesion was compatible with subacute infarct tissue and inflammatory response. Final diagnosis was CM under effect of cervical disc herniation. Contrast-enhanced spinal cord myelopathic lesions are very rare and resemble much more tumors and inflammatory processes. However, the principal treatment approach totally differs depending on pathology. When there are both a disc herniation and a high clinical suspicion; biopsy should be delayed. The most probable solution will be surgery for the disc disease with thorough preoperative scanning of vascular malformations; clinical and radiological close follow-up after surgery. Biopsy or surgical resection can be performed if patient deteriorates despite the primary surgery.

  20. Metabonomic signature analysis of cervical carcinoma and precancerous lesions in women by 1H NMR spectroscopy

    OpenAIRE

    Hasim, Ayshamgul; ALI, MAYINUER; MAMTIMIN, BATUR; Ma, Jun-Qi; Li, Qiao-Zhi; ABUDULA, ABULIZI

    2012-01-01

    1H nuclear magnetic resonance (NMR)-based metabonomics has been used to characterize the metabolic profiles of cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma (CSCC). Principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) were used to model the systematic variation related to patients with CIN or CSCC with healthy controls. Potential metabolic biomarkers were identified using database comparisons, and the one-way a...

  1. Prevalence and risk factors for non-carious cervical lesions in children attending special needs schools in India.

    Science.gov (United States)

    Kumar, Sandeep; Kumar, Arunoday; Debnath, Nitai; Kumar, Amit; K Badiyani, Bhumika; Basak, Debashish; S A Ali, Mohamed; B Ismail, Mohammed

    2015-03-01

    We assessed the prevalence and risk factors for development of non-carious cervical lesions (NCCLs) in children attending special needs schools in India. The participants were 395 children aged 12-15 years with disabilities in learning, communication, physical function, and/or development. A questionnaire was designed in order to collect information on sociodemographic characteristics, oral hygiene practices, dietary habits, and risk factors for NCCLs. The chi-square test, bivariate analysis, and logistic regression analysis were used to analyze the data. Presence of NCCLs was associated with use of toothpowder or other materials for teeth cleaning, use of harder toothbrushes, use of a horizontal scrub technique for toothbrushing, consumption of a vegetarian diet, and greater consumption of lemon. The overall prevalence of NCCLs was 22.7%. Most lesions involved minimal loss of contour or defects health care among children attending special needs schools. PMID:25807907

  2. Oncogenic Human Papillomavirus DNA Loads in Human Immunodeficiency Virus-Positive Women with High-Grade Cervical Lesions Are Strongly Elevated

    OpenAIRE

    Weissenborn, S. J.; Funke, A. M.; Hellmich, M; Mallmann, P.; Fuchs, P G; Pfister, H. J.; Wieland, U

    2003-01-01

    Human papillomavirus (HPV) DNA loads of six oncogenic HPV types were measured by real-time PCR in cervical scrapes of human immunodeficiency virus (HIV)-infected and uninfected women. In both groups, HPV loads increased with the grade of cervical disease. HIV infection did not affect HPV loads in low-grade lesions but was associated with significantly higher HPV loads in severe dysplasia; highest loads were found in advanced HIV disease. Our data reflect the aggressive course of HPV infection...

  3. Quality of life in women with cervical precursor lesions and cancer:a prospective, 6-month, hospital-based study in China

    Institute of Scientific and Technical Information of China (English)

    Zhi-Mei Zhao; Xiong-Fei Pan; Si-Han Lv; Yao Xie; Shao-Kai Zhang; You-Lin Qiao; Xiao-Rong Qi; Chun-Xia Yang; Fang-Hui Zhao

    2014-01-01

    The overal survival of patients with cervical cancer has improved due to detection at an early stage and availability of comprehensive treatments in China. As patients’ lives prolonged, it is important to understand their health-related quality of life (QoL) during and after treatment. We used the EQ-5D questionnaire to assess QoL of 194 patients with cervical lesions at Sichuan University West China Second Hospital between May 2010 and January 2011. Patients were surveyed before primary treatment and at 1, 3, and 6 months after primary treatment. Results showed a consistent decline in EQ-5D scores in the spectrum of cervical lesions at each time point after treatment (alP < 0.05). For patients with precursor lesions, there was an increasing trend along the timeline of treatment (P < 0.01). For patients with early-stage cervical cancer, EQ-5D scores declined in the first month (P = 0.01) and gradualy increased to higher levels at 6 months post-treatment than those before treatment (P < 0.01). EQ-5D scores followed a similar trend in patients with advanced cervical cancer (P = 0.04), though they did not statisticaly rebound after 6 months (0.84± 0.19 vs. 0.86± 0.11,P = 0.62). Regarding advanced cervical cancer, EQ-5D scores for women above 40 years of age appeared to recover more rapidly and reached higher levels than those for women below 40 years (P = 0.03). Caution and extra care are recommended in the early period of cervical cancer treatment given the slight deterioration in the QoL, and in particular, for younger cervical cancer patients. Our study implies that health care providers may need to improve the health-related QoL of cervical cancer patients.

  4. Cervical Cancer

    Centers for Disease Control (CDC) Podcasts

    2007-03-06

    Did you know that cervical cancer rates differ by race/ethnicity and region? Or that cervical cancer can usually be prevented if precancerous cervical lesions are found by a Pap test and treated? Find out how getting regular Pap tests can save a woman's life.  Created: 3/6/2007 by National Breast and Cervical Cancer Early Detection Program.   Date Released: 4/25/2007.

  5. Analysis of Human Papillomavirus Type 18 Load and Integration Status from Low-Grade Cervical Lesion to Invasive Cervical Cancer▿

    OpenAIRE

    Cheung, Jo L. K.; Cheung, Tak-Hong; Ng, Candy W. Y.; Yu, Mei Y.; Wong, Martin C. S.; Siu, Shing-Shun N.; Yim, So-Fan; Chan, Paul K. S.

    2008-01-01

    The clinical value of viral load and integration testing for human papillomavirus (HPV) remains unclear. Data on HPV type 18 (HPV18) is limited. We examined the HPV18 viral load and integration status of 78 women with normal cervix or neoplasia. While the crude viral load appeared to increase with lesion severity, the association was not significant after normalization with sample cellularity. Unlike reports for HPV16, the amino-terminal 1 region of HPV18 E2 was most frequently (71.0%) disrup...

  6. Trends in the incidence of cervical cancer and severe precancerous lesions in Denmark, 1997-2012

    DEFF Research Database (Denmark)

    Baldur-Felskov, Birgitte; Munk, Christian; Nielsen, Thor Schütt Svane;

    2015-01-01

    PURPOSE: The incidence of cervical cancer, including squamous cell carcinoma (SCC), has been decreasing in several developed countries since the onset of organized screening programs; in some countries, however, the incidence of adenocarcinoma has increased among young women. We investigated......, importantly, they decreased significantly during 2009-2012 in women aged ≤20 years. CONCLUSIONS: The Danish screening program has successfully reduced the incidence of cervical cancer, especially of SCC in older women; however, the program has not significantly reduced the incidence in young women...... or the incidence of adenocarcinoma, which is increasing. Decreases in the incidences of CIN3 and AIS in age groups with high HPV vaccine coverage may herald a future decrease in cervical cancer incidence in young Danish women....

  7. Mapping of HPV transcripts in four human cervical lesions using RNAseq suggests quantitative rearrangements during carcinogenic progression.

    Science.gov (United States)

    Chen, Jinmiao; Xue, Yuezhen; Poidinger, Michael; Lim, Thimothy; Chew, Sung Hock; Pang, Chai Ling; Abastado, Jean-Pierre; Thierry, Françoise

    2014-08-01

    Two classes of Human papillomaviruses (HPV) infect the anogenital track: high risk viruses that are associated with risk of cervical cancer and low risk types that drive development of benign lesions, such as condylomas. In the present study, we established quantitative transcriptional maps of the viral genome in clinical lesions associated with high risk HPV16 or low risk HPV6b. Marked qualitative and quantitative changes in the HPV16 transcriptome were associated with progression from low to high grade lesions. Specific transcripts encoding essential regulatory proteins such as E7, E2, E1^E4 and E5 were identified. We also identified intrinsic differences between the HPV6b-associated condyloma transcript map and that of the HPV16-associated low grade CIN specifically regarding promoter usage. Characterization and quantification of HPV transcripts in patient samples thus establish the impact of viral transcriptional regulation on the status of HPV-associated lesions and may therefore help in defining new biologically-relevant prognosis markers. PMID:25092457

  8. Low NKp30, NKp46 and NKG2D expression and reduced cytotoxic activity on NK cells in cervical cancer and precursor lesions

    Directory of Open Access Journals (Sweden)

    Bravo-Cuellar Alejandro

    2009-06-01

    Full Text Available Abstract Background Persistent high risk HPV infection can lead to cervical cancer, the second most common malignant tumor in women worldwide. NK cells play a crucial role against tumors and virus-infected cells through a fine balance between activating and inhibitory receptors. Expression of triggering receptors NKp30, NKp44, NKp46 and NKG2D on NK cells correlates with cytolytic activity against tumor cells, but these receptors have not been studied in cervical cancer and precursor lesions. The aim of the present work was to study NKp30, NKp46, NKG2D, NKp80 and 2B4 expression in NK cells from patients with cervical cancer and precursor lesions, in the context of HPV infection. Methods NKp30, NKp46, NKG2D, NKp80 and 2B4 expression was analyzed by flow cytometry on NK cells from 59 patients with cervical cancer and squamous intraepithelial lesions. NK cell cytotoxicity was evaluated in a 4 hour CFSE/7-AAD flow cytometry assay. HPV types were identified by PCR assays. Results We report here for the first time that NK cell-activating receptors NKp30 and NKp46 are significantly down-regulated in cervical cancer and high grade squamous intraepithelial lesion (HGSIL patients. NCRs down-regulation correlated with low cytolytic activity, HPV-16 infection and clinical stage. NKG2D was also down-regulated in cervical cancer patients. Conclusion Our results suggest that NKp30, NKp46 and NKG2D down-regulation represent an evasion mechanism associated to low NK cell activity, HPV-16 infection and cervical cancer progression.

  9. Low NKp30, NKp46 and NKG2D expression and reduced cytotoxic activity on NK cells in cervical cancer and precursor lesions

    International Nuclear Information System (INIS)

    Persistent high risk HPV infection can lead to cervical cancer, the second most common malignant tumor in women worldwide. NK cells play a crucial role against tumors and virus-infected cells through a fine balance between activating and inhibitory receptors. Expression of triggering receptors NKp30, NKp44, NKp46 and NKG2D on NK cells correlates with cytolytic activity against tumor cells, but these receptors have not been studied in cervical cancer and precursor lesions. The aim of the present work was to study NKp30, NKp46, NKG2D, NKp80 and 2B4 expression in NK cells from patients with cervical cancer and precursor lesions, in the context of HPV infection. NKp30, NKp46, NKG2D, NKp80 and 2B4 expression was analyzed by flow cytometry on NK cells from 59 patients with cervical cancer and squamous intraepithelial lesions. NK cell cytotoxicity was evaluated in a 4 hour CFSE/7-AAD flow cytometry assay. HPV types were identified by PCR assays. We report here for the first time that NK cell-activating receptors NKp30 and NKp46 are significantly down-regulated in cervical cancer and high grade squamous intraepithelial lesion (HGSIL) patients. NCRs down-regulation correlated with low cytolytic activity, HPV-16 infection and clinical stage. NKG2D was also down-regulated in cervical cancer patients. Our results suggest that NKp30, NKp46 and NKG2D down-regulation represent an evasion mechanism associated to low NK cell activity, HPV-16 infection and cervical cancer progression

  10. Cervical Cytology Smear Combined Colposcopy in the Diagnosis of Cervical Lesions in Clinical Observa-tion%宫颈细胞学涂片联合阴道镜诊断宫颈病变的临床观察

    Institute of Scientific and Technical Information of China (English)

    许盛芳

    2015-01-01

    Objective To explore the cervical cytological smear the clinical effect of combined colposcopy in the di-agnosis of cervical lesions.Methods Between January 2013 and December 2013 in our hospital to accept the cervical cytological smear combined colposcope examination of 880 cases of married women as the research object, on the cervical lesions of inspection, analysis of the clinical condition.Results Of cervical smear cytologic examination and vaginoscope diagnosis coincidence rate in RCI score photogenic compared with significant difference ( P<0.05) , after statistics treat-ment, under colposcopy in the diagnosis of CIN sensitivity was 94.84%, specificity is 88.81%, both the positive pre-dictive value was 72.31% and negative predictive value was 95.63%.Conclusions Cervical cytological smear com-bined colposcope examination before screening of cervical lesions can ensure cerical cancer lesions and early diagnosis of cervical cancer, can also become local screening test for cervical cancer lesion before effective policies.%目的:探讨宫颈细胞学涂片联合阴道镜诊断宫颈病变的临床效果。方法选取2013年1月~2013年12月在我院接受宫颈细胞学涂片联合阴道镜检查的880例已婚妇女作为研究对象,对其进行宫颈病变的检查,分析其临床情况。结果宫颈涂片细胞学检查与阴道镜下RCI评分诊断在符合率上相比较差异具有显著性( P<0.05),经统计学处理后,阴道镜下诊断CIN的敏感性是94.84%,特异性是88.81%,两者联合的阳性预测值是72.31%,阴性预测值是95.63%。结论宫颈细胞学涂片联合阴道镜检查筛选子宫颈病变可以保证宫颈癌前病变和前期宫颈癌的确诊,还可以成为当地筛选检查宫颈癌前病变的有效政策。

  11. Performance of visual inspection with acetic acid and human papillomavirus testing for detection of high-grade cervical lesions in HIV positive and HIV negative Tanzanian women

    DEFF Research Database (Denmark)

    Dartell, Myassa Arkam; Rasch, Vibeke; Iftner, Thomas;

    2014-01-01

    , and HPV-testing to detect cytologically diagnosed high grade lesions or cancer (HSIL+). Women from different areas in Tanzania were invited by public announcement to cervical cancer screening organized by Ocean Road Cancer Institute (Dar-es-Salaam). A total of 3,767 women were enrolled. Women...

  12. Restoration of non-carious cervical lesions with ceramic inlays: A possible model for clinical testing of adhesive cements

    Directory of Open Access Journals (Sweden)

    Michal Staninec

    2012-01-01

    Full Text Available Introduction: There are many luting cements coming to market which claim to be adhesive, but there is no clinical protocol currently for testing these claims. There is a standardized protocol for testing direct restorations bonded to dentin and it is used extensively. Case Report: We describe a clinical procedure for restoring a non-carious cervical lesion (NCCL with a ceramic inlay using Computer-Aided Design and Computer-Aided Manufacturing (CAD-CAM technology and an adhesive resin cement.The procedure was straightforward and the result was good at one month. Discussion: NCCL′s can be restored with CAD-CAM technology in one appointment. This technique can be used to clinically test adhesion of luting cements to dentin, similarly to the current standard for direct restorations.

  13. The significance of HPV genotyping in cervical lesions%宫颈组织病变与检测HPV基因分型的意义

    Institute of Scientific and Technical Information of China (English)

    张达衡; 陈红玲; 杨春媚; 陈瑞林

    2013-01-01

    目的 了解宫颈病变患者人乳头瘤病毒HPV感染率及基因型分布情况.探讨人乳头瘤病毒基因分型与宫颈组织病变的相关性,为临床宫颈癌的筛查、防治提供参考.方法 收集在本院诊治2 000例疑似宫颈病变女性,应用基因芯片技术检测23种HPV基因型,统计HPV各基因型的感染率,分析HPV及基因型分布与子宫病变的关系.结果 2000例宫颈疑似宫颈病变女性中,基因芯片检测出的HPV阳性标本662例,HPV感染率为33.1%(662/2 000).354例宫颈不同程度病变组织中HPV阳性295例,其中LSIL,HSIL及宫颈癌样本中HPV的检出率分别为76.6%(157/205)、91.9%(125/136)、100%(13/13).共检出12种HPV基因型,检出率最高的5种基因型分别为HPV16,18,58,31,52.宫颈病变级别越高,HPV多重感染率越高.结论 HPV亚型感染与宫颈组织不同程度病变密切相关,HPV基因分型检测及诊断在宫颈病变及宫颈癌筛查及防治过程中具有重要意义.%Objective To investigate the infection rate of human papillomavirus (HPV) and distribution of HPV genotypes in cervical lesions,and discuss the correlationbetween HPV genotypes and cervical lesions to provide a reference for cervical cancer screening,prevention and treatment.Methods 2 000 cases of women with suspected cervical lesions were detected by 23 cases of HPV genotyping based on gene chip technology,and infection rates of HPV genotypes and the correlation between HPV genotypes and cervical lesions were analyzed.Results 662 cases were HPV positive in 2 000 cases of women with suspected cervical lesions,with the HPV infection rate of 33.1 % (662/2 000),and 295 cases were HPV positive in 354 cases of women with cervical lesions.For LSIL,HSIL and cervical cancer,HPV detection rates were 76.6% (157/205),91.9% (125/136),100% (13 / 13),respectively.12 kinds of HPV genotypes were detected,and the top five genotypes of the highest detection rate were HPV16,18,58,31,52.The higher

  14. Screening Methods for Cervical Lesion and its New Development%宫颈病变筛查方法及其新进展综述

    Institute of Scientific and Technical Information of China (English)

    邓晓红

    2016-01-01

    综述宫颈病变的筛查技术及新进展,早期发现宫颈癌和提高治愈率。宫颈癌是最常见的妇科恶性肿瘤之一,严重威胁着妇女的健康,且近几年趋向年轻化。人乳头瘤病毒(HPV DNA)感染是引起宫颈病变尤其是宫颈癌的主要原因,TCT是宫颈细胞学筛查的一种新的全自动细胞学检测技术,阴道镜是宫颈早期浸润癌筛查的重要应用。三者联合筛查宫颈病变,早期发现、早期诊断和早期干预宫颈的癌前病变,能够有效预防宫颈癌发生,降低宫颈癌的发病率和死亡率。%This paper reviews screening technologies and new developments for cervical lesions, early detection of cervical cancer, so as to improve in cure rate. Cervical cancer is one of the most common gynecologic malignant tumor, it is a serious threat to women's health, and in recent years it trends to target the younger ages. Human papilloma virus (HPV DNA) infection is the primary cause of cervical lesions, especially for cervical cancer. TCT is a new automatic cytology detection technology for cervical cytology screening. Colposcopy is an important application in early invasive cervical cancer screening. Combining the above mentioned three screening technologies could achieve the purposes of early detection, early diagnosis and early intervention of cervical precancerous lesions, so as to effectively prevent the occurrence of cervical cancer, reduce the morbidity and mortality of cervical cancer.

  15. Metabonomic signature analysis of cervical carcinoma and precancerous lesions in women by (1)H NMR spectroscopy.

    Science.gov (United States)

    Hasim, Ayshamgul; Ali, Mayinuer; Mamtimin, Batur; Ma, Jun-Qi; Li, Qiao-Zhi; Abudula, Abulizi

    2012-06-01

    (1)H nuclear magnetic resonance (NMR)-based metabonomics has been used to characterize the metabolic profiles of cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma (CSCC). Principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) were used to model the systematic variation related to patients with CIN or CSCC with healthy controls. Potential metabolic biomarkers were identified using database comparisons, and the one-way analysis of variance (ANOVA) test was used to examine the significance of the metabolites. Compared with plasma obtained from the healthy controls, plasma from patients with CIN had higher levels of very-low density lipoprotein (VLDL), acetone, unsaturated lipid and carnitine, together with lower levels of creatine, lactate, isoleucine, leucine, valine, alanine, glutamine, histidine, glycine, acetylcysteine, myo-inositol, choline and glycoprotein. Plasma from patients with CSCC had higher levels of acetate and formate, together with lower levels of creatine, lactate, isoleucine, leucine, valine, alanine, glutamine, histidine and tyrosine compared with the plasma of the healthy controls. In addition, compared with the plasma of patients with CIN, the plasma of CSCC patients had higher levels of acetate, formate, lactate, isoleucine, leucine, valine, alanine, glutamine, histidine, tyrosine, acetylcysteine, myo-inositol, glycoprotein, α-glucose and β-glucose, together with lower levels of acetone, unsaturated lipid and carnitine. Moreover, the profiles showed high feasibility and specificity by statistical analysis with OPLS-DA compared to the Thinprep cytology test (TCT) by setting the histopathological outcome as standard. The metabolic profile obtained for cervical cancer is significant, even for the precancerous disease. This suggests a systemic metabolic response to cancer, which may be used to identify potential early diagnostic biomarkers of the cancer and to establish

  16. Association between cervical lesion grade and micronucleus frequency in the Papanicolaou test

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    Caroline Tanski Bueno

    2014-09-01

    Full Text Available The aim of this study was to evaluate the association between the frequency of micronuclei (MN and the cellular changes detected in the conventional Papanicolaou test. One hundred and seventy-four Papanicolaou test smears with cellular changes were examined. MN screening was done in cytopathological smears by counting 1,000 cervical cells in a light microscope. MN frequencies were significantly higher in the group with cellular changes compared to the control group (p < 0.001. The mean MN frequencies were 0.95 ± 1.12 (mean ± SD in the control group (n = 223, 2.98 ± 1.20 in individuals with atypical squamous cells of undetermined significance (ASC-US (n = 50, 4.04 ± 1.45 in cervical intraepithelial neoplasia (CIN I (n = 52, 5.97 ± 1.83 in CIN II (n = 30, 7.29 ± 1.55 in CIN III (n = 17 and 8.64 ± 1.55 in invasive cancer (n = 25. These findings suggest that MN monitoring should be included as an additional criterion for the early detection of cytogenetic damage in routine examinations. This monitoring should be done in the same smear as used for cytopathological examination. More specific and systematic studies are necessary to confirm this proposal.

  17. Risk assessment on liquid based cytology test and human papilloma virus L1 Nuclecapsid protein detection in the diagnosis of cervical lesions and its progress

    Institute of Scientific and Technical Information of China (English)

    Ling-Zhi Chen

    2016-01-01

    Objective: To discuss the clinical value of liquid based cytology test in the diagnosis of cervical lesions and to evaluate the expression difference and significance of human papilloma virus L1(HPV L1) protein in exfoliative cells of different cervical lesions. Methods: A total of 1 400 cases of patients in gynaecological clinics of our hospital from January 2009 to August 2013 were selected and were given liquid based cytology test(LCT) examination and HPV L1 protein expression detection in exfoliative cells. Meanwhile, cervical biopsy pathology results were taken as baseline for make a comparison. Results: (1) In such1400 cases of women: LCT(+)-30 cases, accounting for 2.1%, HPV L1 protein detection(+)-18 cases, accounting for 1.29%; LCT and HPV L1 protein detection(+)-8 cases, LCT and HPV L1 protein detection(-)- 1360 cases. (2)Pathological tissue biopsy was performed on 30 cases of patients with LCT(+), results showed that(+)were 23 cases; pathological tissue biopsy was performed on 18 cases of patients with HPV L1 protein(+),results showed that (+)were 14 cases. Among 1 360 cases with LCT and HPV L1 protein detection(-), 497 cases were willing to accept the pathological biopsy, and the results showed that 1 case presented(+), accounting for 0.2%. Total 545 cases were willing to accept the pathological biopsy, among whom, 38 cases presented(+), accounting for 6.97%;(3)Sensitivity and specificity of LCT combined with HPV L1 protein detection were higher than single-method detection, and difference had statistical significance. Conclusion: liquid based cytology test combined with HPV L1 protein detection could improve the diagnostic rate of cervical lesions, and were expected as the effective method in the early clinical screening of cervical neoplasia lesions.

  18. Cytohistological correlation and accuracy of the pap smear test in diagnosis of cervical lesions: a hospital based cross-sectional study from Odisha, India

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    Reena Naik

    2015-09-01

    Full Text Available Background Cervical carcinoma is one of the most common causes of mortality among women.Early detection can be done by Papanicolaou (Papsmear test - a simplest, safe, cost effective and non invasive procedure. The main objective of this study was to categorize Pap smears for cytohistologicalexamination as well as clinically correlate to analyze sensitivity, specificity and positive predictive value of Pap smear. Methods In this prospective study 417 Pap smears performed, cytohistological correlation was done in 104 cases because patients had undergone both Pap smear and cervical biopsy.Detailed history was taken and clinical examination was done. Pap smear sample was collected from cervix and reporting was made according to Bethesda 2001 classification.Cytological findings were correlated with histopathology. Results Overall concordance rate was 60.7%. Concordance rate for malignancy was 100%, for inflammatory lesions 70.8% and for cervical intraepithelial neoplasia (CIN 33.3%. Common age group presented for screening was40-50 years.Commonest clinical presentationwas bleeding per vaginum. Conclusion The study provides good cyto-histopathology correlation in detecting high grade lesions and malignancy. Although Pap smear sensitivity was low but can be increased by adequate sampling and avoiding technical errors.Bethesda system is strongly recommended for adequacy of sampling to minimize inconsistency.Regular screening should be advised to the patients for the early detection of cervical carcinoma.

  19. Resolución endovascular de lesiones por arma de fuego en la región cervical

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    Sebastián Rizzone

    2016-01-01

    Full Text Available Introducción: Las heridas producidas por armas de fuego que comprometen la región cervical son materia de controversia en cuanto a cuál es el mejor método para tratarlas. La resolución endovascular de este tipo de patología ha cobrado gran relevancia en los últimos años debido al desarrollo de nuevos dispositivos y, consecuentemente, a la menor incidencia de complicaciones inherentes al procedimiento. Objetivo: Determinar el rol del tratamiento endovascular en la resolución de las lesiones cervicales por arma de fuego. Material y métodos: Se incluyeron 76 pacientes que sufrieron lesiones cervicales por arma de fuego, a los cuales se les realizó angiografía de los vasos supraaórticos para decidir la conducta a seguir. Resultados: Del total de 76 pacientes, 47 (61,8% presentaron una angiografía patológica; de estos, en 26 se decidió la resolución endovascular de la lesión, implantándose 1,1 stents por paciente. La estadía intrahospitalaria fue en promedio de 10,4 días. A los 30 días de seguimiento, 2 pacientes presentaron secuela neurológica y uno evolucionó con sepsis. En el seguimiento alejado con un promedio de 4 años se registró una muerte a los 117 días de realizado el procedimiento. Conclusiones: La intervención endovascular ha ganado mayor protagonismo con el desarrollo de nuevos dispositivos que permiten el tratamiento de patologías cada vez más complejas y reducir el tiempo de internación intrahospitalaria, como también las complicaciones relacionadas con el procedimiento.

  20. Papanicolaou Test in the Detection of High-Grade Cervical Lesions: A Re-evaluation Based on Cytohistologic Non-correlation Rates in 356 Concurrently Obtained Samples

    OpenAIRE

    Carns, Bhavini; Fadare, Oluwole

    2008-01-01

    Studies evaluating the routine Papanicolaou (Pap) test have traditionally used as the reference gold standard, the diagnoses on the follow-up histologic samples. Since the latter are typically obtained days to weeks after the Pap test, the accuracy of the resultant comparison may be affected by interim factors, such as regression of human papillomavirus, new lesion acquisitions or colposcopy-associated variability. A subset of our clinicians have routinely obtained cervical cytology samples i...

  1. Abfraction lesions: etiology, diagnosis, and treatment options

    Science.gov (United States)

    Nascimento, Marcelle M; Dilbone, Deborah A; Pereira, Patricia NR; Duarte, Wagner R; Geraldeli, Saulo; Delgado, Alex J

    2016-01-01

    Abfraction is a type of noncarious cervical lesion (NCCL) characterized by loss of tooth tissues with different clinical appearances. Evidence supports that abfraction lesions, as any NCCLs, have a multifactorial etiology. Particularly, the cervical wear of abfraction can occur as a result of normal and abnormal tooth function and may also be accompanied by pathological wear, such as abrasion and erosion. The interaction between chemical, biological, and behavioral factors is critical and helps to explain why some individuals exhibit more than one type of cervical wear mechanism than others. In an era of personalized dentistry, patient risk factors for NCCLs must be identified and addressed before any treatment is performed. Marked variations exist in dental practice concerning the diagnosis and management of these lesions. The lack of understanding about the prognosis of these lesions with or without intervention may be a major contributor to variations in dentists’ management decisions. This review focuses on the current knowledge and available treatment strategies for abfraction lesions. By recognizing that progressive changes in the cervical area of the tooth are part of a physiologically dynamic process that occurs with aging, premature and unnecessary intervention can be avoided. In cases of asymptomatic teeth, where tooth vitality and function are not compromised, abfraction lesions should be monitored for at least 6 months before any invasive procedure is planned. In cases of abfraction associated with gingival recession, a combined restorative-surgical approach may be performed. Restorative intervention and occlusal adjustment are not indicated as treatment options to prevent further tooth loss or progression of abfraction. The clinical decision to restore abfraction lesions may be based on the need to replace form and function or to relieve hypersensitivity of severely compromised teeth or for esthetic reasons. PMID:27217799

  2. Co-infections associated with human immunodeficiency virus type 1 in pregnant women from southern Brazil: high rate of intraepithelial cervical lesions

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    Michele Tornatore

    2012-03-01

    Full Text Available Human immunodeficiency virus type 1 (HIV-positive pregnant women require specific prophylactic and therapeutic approaches. The efficacy of established approaches is further challenged by co-infection with other sexually transmitted diseases (STDs. The objective of this study was to determine the prevalence of co-infections in pregnant women infected with different HIV-1 subtypes and to relate these findings, together with additional demographic and clinical parameters, to maternal and infant outcomes. Blood samples from pregnant women were collected and tested for syphilis, hepatitis B virus (HBV and hepatitis C virus (HCV. Human papillomavirus (HPV diagnosis was evaluated by the presence of alterations in the cervical epithelium detected through a cytopathological exam. Medical charts provided patient data for the mothers and children. Statistical analyses were conducted with STATA 9.0. We found a prevalence of 10.8% for HCV, 2.3% for chronic HBV, 3.1% for syphilis and 40.8% for HPV. Of those co-infected with HPV, 52.9% presented high-grade intraepithelial lesions or in situ carcinoma. Prematurity, birth weight, Apgar 1' and 5' and Capurro scores were similar between co-infected and non-co-infected women. The presence of other STDs did not impact maternal and concept outcomes. More than half of the patients presenting cervical cytology abnormalities suggestive of HPV had high-grade squamous intraepithelial lesions or cervical cancer, evidencing an alarming rate of these lesions.

  3. Risk factors for cervical carotid and intracranial cerebrovascular lesions in patients undergoing coronary artery bypass grafting. Preoperative evaluation using magnetic resonance imaging and angiography

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    Makino, Masahiro [Kyoto Prefectural Univ. of Medicine (Japan). Research Inst. for Neurological Diseases and Geriatrics

    2001-12-01

    Recently neurologic complications after coronary artery bypass grafting (CABG) have received increasing attention. There is no detailed report about the risk factors for these complications, although stenosis in the cervical and intracranial arteries, especially in Japanese patients, latent ischemic brain lesions and preoperative neurological conditions are related to these events. In this prospective study, we evaluated occlusive lesions in the cervical carotid and intracranial arteries, silent brain infarction and cerebral deep white matter lesion with MRA and MRI in patients scheduled to undergo CABG to determine the prevalence of occlusive diseases in cervical carotid and intracranial arteries, latent ischemic change in the brain in this population and to identify preoperative risk factors for these patients. The subjects were 144 consecutive patients (103 men and 41 women, mean age 65.9{+-}9.2 years old) who were scheduled for CABG under elective conditions and who were examined by the same MRI apparatus using the same protocol between November 1998 and March 2001. After routine neurological examination and Mini-Mental State Examination (MMSE) were completed, MRI and MRA were obtained, then the prevalence of abnormalities on MRI and MRA studies and risk factors were evaluated. Cervical carotid artery stenosis with {>=}50% luminal narrowing was detected in 29.2% of the subjects, and that with {>=}75% luminal narrowing was detected in 16.0% of the subjects. Intracranial arterial stenosis showing {>=}50% luminal narrowing was detected in 38.2% of subjects, and that showing {>=}75% luminal narrowing was detected in 19.4% of subjects. Brain infarction was observed in 74.3% of subjects, cerebral deep white matter lesion showing grade 2 or higher on Fazekas classification was observed in 17.4% of the subjects. The characteristics, including possible risk factors of subjects with and without these abnormal findings, were compared. Patients with cervical carotid

  4. Risk factors for cervical carotid and intracranial cerebrovascular lesions in patients undergoing coronary artery bypass grafting. Preoperative evaluation using magnetic resonance imaging and angiography

    International Nuclear Information System (INIS)

    Recently neurologic complications after coronary artery bypass grafting (CABG) have received increasing attention. There is no detailed report about the risk factors for these complications, although stenosis in the cervical and intracranial arteries, especially in Japanese patients, latent ischemic brain lesions and preoperative neurological conditions are related to these events. In this prospective study, we evaluated occlusive lesions in the cervical carotid and intracranial arteries, silent brain infarction and cerebral deep white matter lesion with MRA and MRI in patients scheduled to undergo CABG to determine the prevalence of occlusive diseases in cervical carotid and intracranial arteries, latent ischemic change in the brain in this population and to identify preoperative risk factors for these patients. The subjects were 144 consecutive patients (103 men and 41 women, mean age 65.9±9.2 years old) who were scheduled for CABG under elective conditions and who were examined by the same MRI apparatus using the same protocol between November 1998 and March 2001. After routine neurological examination and Mini-Mental State Examination (MMSE) were completed, MRI and MRA were obtained, then the prevalence of abnormalities on MRI and MRA studies and risk factors were evaluated. Cervical carotid artery stenosis with ≥50% luminal narrowing was detected in 29.2% of the subjects, and that with ≥75% luminal narrowing was detected in 16.0% of the subjects. Intracranial arterial stenosis showing ≥50% luminal narrowing was detected in 38.2% of subjects, and that showing ≥75% luminal narrowing was detected in 19.4% of subjects. Brain infarction was observed in 74.3% of subjects, cerebral deep white matter lesion showing grade 2 or higher on Fazekas classification was observed in 17.4% of the subjects. The characteristics, including possible risk factors of subjects with and without these abnormal findings, were compared. Patients with cervical carotid lesions were

  5. P16INK4a: a potential diagnostic adjunct for prediction of high-grade cervical lesions in liquid-based cytology: with HPV testing and histological correlation.

    Science.gov (United States)

    Wong, Y P; Abdul Raub, S H; Mohd Dali, A Z H; Kassim, F; Visvalingam, V; Zakaria, Z; Kamaluddin, M A; Noor Akmal, S

    2016-08-01

    Human papillomavirus (HPV) is a necessary cause of cervical cancer and its precursors. Increased expression of high-risk hrHPV viral oncogenes in abnormal cells might increase the expression of p16INK4a. We aimed to determine the role of p16INK4a in detecting hrHPV-transformed epithelial cells in liquid-based cervical cytology, and compared the results with hrHPV DNA testing by realtime polymerase chain reaction (RT-PCR). Fifty-seven cytological samples were tested for p16INK4a immunomarker and hrHPV DNA. Test performance of both tests was determined by comparing sensitivity, specificity and predictive values using available histological follow-up data as gold standard. Of 57 samples, 36 (63.2%) showed immunoreactivity for p16INK4a and 43 (75.4%) were hrHPV-infected. A fairly low concordance rate (k = 0.504) between p16INK4a immunolabelling and hrHPV DNA status was noted. For prediction of cervical intraepithelial neoplasia (CIN) II and worse lesions, p16INK4a had a sensitivity and specificity of 93.5% and 60%; whereas hrHPV DNA testing had a sensitivity and specificity of 100% and 20%. Dual testing by combining p16INK4a and hrHPV showed sensitivity and specificity of 100% and 33.3%. In conclusion, p16INK4a is useful in predicting severity of the cytological abnormalities. Although p16INK4a is more specific but less sensitive than hrHPV in detecting high-grade cervical lesions, a combination of both tests failed to demonstrate significant improvement in diagnostic sensitivity, specificity and predictive value. Larger-scale prospective studies are required to assess further whether this biomarker should be routinely used as primary screening tool independently or in combination with hrHPV testing to improve diagnostic accuracy in cervical cytology. PMID:27568665

  6. RARβ在宫颈癌及癌前病变中的表达调控和意义%The association of altered RARβ gene expression with the cervical lesion pathogenesis

    Institute of Scientific and Technical Information of China (English)

    Nafeisha Kadeer; Hui He; Abida Abudoukadeer; Anaguli Ababaikeli; Abulizi Abudula

    2011-01-01

    Objective:Previous reports have shown that the gene promoter region of retinoic acid receptor β (RARβ) was hypermethylated in cervical carcinoma,implying the inhibition of gene transcription.The aim of this study was to investigate the association of cervical cancer development with the RARβ gene expression at the mRNA and protein level to assess the impact of RARβ as a marker for early detection of the cancer.Methods:We collected 126 cases of formalin fixed and paraffin embedded cervical tissue specimens as well as 37 cases of fresh tissue samples from women with cervicitis,cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma (CSCC).The RARβ mRNA and protein expression was detected by quantitative RT-PCR and immunohistochemistry,respectively.Results:(1) The mRNA expression of RARβ in CIN and cervical cancer was markedly decreased compared to cervicitis with a statistically very significant difference,but no difference was found between CIN and cervical cancer.(2) RARβ protein was normally expressed in the epithelial cells of cervicitis and partially lost in a few cases,but with the development of cervical lesion pathogenesis and cancer,a significant loss of protein expression was detected in CIN (38%) and CSCC (57%) compared to cervicitis (P < 0.01).Conclusion:The downregulation of RARβ transcription or loss of protein expression is an important indicator of cervical cancer and its precursur lesions.The detection of RARβ expression coupled with aberrant methylation of the gene may become a biomarker for the early prognosis or diagnosis of the cancer.

  7. AN UPWARD TREND IN DNA P16INK4A METHYLATION PATTERN AND HIGH RISK HPV INFECTION ACCORDING TO THE SEVERITY OF THE CERVICAL LESION

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    Fernanda Nahoum Carestiato

    2013-09-01

    Full Text Available SUMMARY High-risk human papillomavirus (hr-HPV infection is necessary but not sufficient for cervical cancer development. Recently, P16INK4A gene silencing through hypermethylation has been proposed as an important cofactor in cervical carcinogenesis due to its tumor suppressor function. We aimed to investigate P16INK4A methylation status in normal and neoplastic epithelia and evaluate an association with HPV infection and genotype. This cross-sectional study was performed with 141 cervical samples from patients attending Hospital Moncorvo Filho, Rio de Janeiro. HPV detection and genotyping were performed through PCR and P16INK4A methylation by nested-methylation specific PCR (MSP. HPV frequency was 62.4% (88/141. The most common HPV were HPV16 (37%, HPV18 (16.3% and HPV33/45(15.2%. An upward trend was observed concerning P16INK4A methylation and lesion degree: normal epithelia (10.7%, low grade lesions (22.9%, high grade (57.1% and carcinoma (93.1% (p < 0.0001. A multivariate analysis was performed to evaluate an association between methylation, age, tobacco exposure, HPV infection and genotyping. A correlation was found concerning methylation with HPV infection (p < 0.0001, hr-HPV (p = 0.01, HSIL (p < 0.0007 and malignant lesions (p < 0.0001. Since viral infection and epigenetic alterations are related to cervical carcinoma, we suggest that P16INK4A methylation profile maybe thoroughly investigated as a biomarker to identify patients at risk of cancer.

  8. SPECTRUM OF CERVICAL LESIONS IN CIMS, BILASPUR: A 5 YEAR RETROSPECTIVE STUDY OF 215 CASES IN A TERTIARY HOSPITAL OF CENTRAL INDIA

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    Sadhna

    2015-10-01

    Full Text Available BACKGROUND AND OBJEC TIVE: Cancer of the cervix is a leading cause of morbidity and mortality among women W orld W ide. Therefore to curb the disease there is need of awareness of this disease. This study is aimed to categorize the premalignant and malignant lesions at the earliest, to reduce the mortality and morbidity. It also aimed to know the incidence of malignancies at our set up and to calculate distribution of patient in relation to parity and symptoms. DESIGN AND SETTING: Study included 215 patients with complain of white dis charge per vagina, per vaginal bleeding and backache attending the gynecology OPD over a period of 05 years. PATIENT AND METHODS: Patients were subjected to cervical biopsy and biopsies were sent to pathology department. Detailed clinical history, age, age at marriage, parity and socio - economic status was obtained. RESULT: Result were classified histopathological l y as inflammatory lesions 70 cases, polypoidal lesion were 30, LSIL accounted for 32 cases and HSIL were 20 cases and 30 were malignant lesions. U nder malignant category moderately differentiated squamous cell carcinoma was the commonest. Maximum numbers of patients were subjected to cervical biopsies in 3 rd decade of life. Malignancies were common in 3 rd & 4 th decade of life. Most of the cases were of parity 4. CONCLUSION : Tissue biopsy is a valuable diagnostic procedure on which surgeons and radiologists still rely.

  9. Clinical study on colposcopy combined with cervical smear in detection of cervical lesions%阴道镜联合宫颈涂片检测宫颈病变的临床研究

    Institute of Scientific and Technical Information of China (English)

    周鸿; 朱瑾

    2012-01-01

    目的:探讨阴道镜联合宫颈涂片检测宫颈病变的临床应用价值.方法:对已婚妇女行宫颈细胞学涂片联合阴道镜检查对宫颈病变进行筛查,以组织病理学诊断为金标准,对结果进行分析.结果:接受宫颈涂片检查的1 030例已婚妇女中有156例行阴道镜下活检病理诊断,其中慢性宫颈炎91例,HPV感染15例,CIN Ⅰ 22例,CINⅡ8例,CINⅢ2例,宫颈癌6例.经阴道镜下RCI评分诊断CIN36例,其中CIN Ⅰ 21例、CINⅡ9例、CINⅢ6例;与阴道镜下活检病理诊断的符合率为94.74%(36/38).宫颈涂片细胞学检查巴氏Ⅲ级以上可疑CIN24例,其中阴道镜下活检病理证实14例,宫颈涂片细胞学检查诊断符合率为58.33% (14/24).阴道镜下RCI评分诊断CIN符合率与宫颈涂片细胞学检查诊断符合率相比差异有统计学意义(P<0.05).统计学处理得出阴道镜诊断CIN的敏感性为95.50%,特异性为89.26%,两者联合的阳性预测值为72.21%,阴性预测值为95.85%.结论:宫颈细胞学涂片联合阴道镜检查筛查子宫颈病变能提高宫颈癌前病变及早期宫颈癌的诊断率,可作为该地区筛查宫颈癌前病变的可行方法.%Objective: To explore the clinical application value of colposcopy combined with cervical smear in detection of cervical lesions. Methods- The married women underwent cervical cytological smear combined with colposcopy to screen cervical lesions, histopatho-logical diagnosis was designed as gold standard, the results were analyzed. Results: Among 1 030 married women undergoing cervical smear, 156 women underwent biopsy under colposcope and pathological examination; 91 cases with chronic cervinitis, 15 cases with human papillo-mavirus (HPV) infection, 22 cases with cervical intraepithelial neoplasia (CIN) 1,8 cases with CIN Q , 2 cases with CIN 1, and 6 cases with cervical cancer were found. Thirty - six cases were diagnosed as CIN by colposcopic RCI score, including 21 cases with

  10. HPV16-E2 induces prophase arrest and activates the cellular DNA damage response in vitro and in precursor lesions of cervical carcinoma.

    Science.gov (United States)

    Xue, Yuezhen; Toh, Shen Yon; He, Pingping; Lim, Thimothy; Lim, Diana; Pang, Chai Ling; Abastado, Jean-Pierre; Thierry, Françoise

    2015-10-27

    Cervical intraepithelial neoplasia (CIN) is caused by human papillomavirus (HPV) infection and is the precursor to cervical carcinoma. The completion of the HPV productive life cycle depends on the expression of viral proteins which further determines the severity of the cervical neoplasia. Initiation of the viral productive replication requires expression of the E2 viral protein that cooperates with the E1 viral DNA helicase. A decrease in the viral DNA replication ability and increase in the severity of cervical neoplasia is accompanied by simultaneous elevated expression of E6 and E7 oncoproteins. Here we reveal a novel and important role for the HPV16-E2 protein in controlling host cell cycle during malignant transformation. We showed that cells expressing HPV16-E2 in vitro are arrested in prophase alongside activation of a sustained DDR signal. We uncovered evidence that HPV16-E2 protein is present in vivo in cells that express both mitotic and DDR signals specifically in CIN3 lesions, immediate precursors of cancer, suggesting that E2 may be one of the drivers of genomic instability and carcinogenesis in vivo. PMID:26474276

  11. Analysis of Sensitivity, Specificity, and Positive and Negative Predictive Values of Smear and Colposcopy in Diagnosis of Premalignant and Malignant Cervical Lesions.

    Science.gov (United States)

    Barut, Mert Ulaş; Kale, Ahmet; Kuyumcuoğlu, Umur; Bozkurt, Murat; Ağaçayak, Elif; Özekinci, Server; Gül, Talip

    2015-01-01

    BACKGROUND This study aimed to examine the positive and negative predictive value in the diagnosis of premalignant and malignant lesions of cervical colposcopy, the sensitivity and specificity of smear, and to evaluate the correlation with histopathology of abnormal cytology and colposcopy. MATERIAL AND METHODS The criteria for inclusion of patients with unhealthy cervix in the study were: Erosion, Chronic cervicitis, and Healed lacerations, Hypertrophied cervix, bleeding on touch, suspicious growth/ulcer/polyp on the cervix, and abnormal discharges from the cervix. Women with frank carcinoma cervix, pregnant females, patients with bleeding per vaginum at the time of examination, and those who had used vaginal medications, vaginal contraceptives or douches in the last 48 h of examination were excluded from the study. Demographic analysis was performed for 450 patients who were admitted to the clinic. Sensitivity, specificity, positive predictive value and negative predictive values of patients to identify cervical pathologies of smear and colposcopy were histopathologically calculated. The statistical software package SPSS 15.0 (SPSS Inc., Chicago, IL, USA) and Spearman's and Chi-Square tests were used for statistical analysis. RESULTS Sensitivity, specificity, PPD and NDP of smear were 0.57%, 0.76%, 0.26%, 0.92% respectively. Sensitivity, specificity, PPD and NDP of colposcopy were 0.92%, 0.67%, 0.52%, 0.96% respectively. A statistically significant correlation was found between abnormal cytology and histopathology, and abnormal colposcopy finding and histopathology. CONCLUSIONS Women with clinical diagnosis of unhealthy cervix should be evaluated by cytology to detect any premalignant or malignant lesions. It was concluded that Pap smear, colposcopy and histopathology should be collectively evaluated to evaluate cervical findings in low socio-economic regions. PMID:26655816

  12. Clinical Effect of Percutaneous Nucleoplasty with Radiofrequency Abrasion for Treatment of Cervical Spondylotic Radiculopathy%经皮射频消融术治疗神经根型颈椎病的疗效分析

    Institute of Scientific and Technical Information of China (English)

    张顺聪; 杨志东; 梁德; 江晓兵; 晋大祥; 庄洪; 姚珍松

    2012-01-01

    [目的]探讨经皮射频消融髓核成形术治疗神经根型颈椎病的疗效及安全性.[方法]2008年1月至2010年8月应用经皮射频消融髓核成形术治疗神经根型颈椎病患者27例,比较术前、术后2周及末次随访时的疼痛视觉模拟评分(VAS)和颈部功能障碍指数(NDI),评估临床结果,以及影像学检查颈椎间盘突出、椎体间不稳定等情况,并记录手术并发症.[结果]27例患者总共手术椎间隙37个,其中单节段19例,双节段6例,三个节段2例.随访时间1年~28个月,平均19.8个月.未发现手术节段出现不稳定,未发现手术节段椎间隙出现塌陷.27例患者平均VAS评分为术前(7.84±1.47)分,术后2周减少到(2.44±1.61)分,末次随访为(3.16±1.17)分.平均NDI术前为(61.15±15.71)%,术后2周减少到(16.48±13.29)%,末次随访为(14.42±11.55)%.术后2周及末次随访VAS评分及NDI评分均较术前有显著改善,差异均有统计学意义(P<0.05).无1例患者出现脊髓、神经、大血管损伤及术后感染等并发症;无患者出现脊膜破裂脑脊液漏;无患者出现术中刀头断裂.[结论]经皮射频消融髓核成形术是一种安全的微创手术,如果适应症选择正确,能够有效治疗神经根型颈椎病.%Objective To analyze the clinical outcome and safety of percutaneous nucleoplasty with radiofrenquency abrasion for treatment of cervical spondylotic radiculopathy. Methods From January of 2008 to December of 2010, 27 patients with cervical spondylotic radiculopathy received percutaneous nucleoplasty. The scores of visual ( Continued on page 253)analog scale (VAS) and neck disability questionnaires (NDI) were evaluated before the operation, 2 weeks after the operation, and at the final follow-up. Furthermore, the herniation of intervertebral disk and intervertebral instability were monitored by imageological examination, and all of the intraoperative and postoperative complications were recorded. Results

  13. Comparison of Onclarity Human Papillomavirus (HPV) Assay with Hybrid Capture II HPV DNA Assay for Detection of Cervical Intraepithelial Neoplasia Grade 2 and 3 Lesions

    OpenAIRE

    Bottari, F.; Sideri, M; Gulmini, C.; Igidbashian, S.; Tricca, A.; Casadio, C.; Carinelli, S; Boveri, S; Ejegod, D.; Bonde, J; Sandri, M. T.

    2015-01-01

    Analytical and clinical performance validation is essential before introduction of a new human papillomavirus (HPV) assay into clinical practice. This study compares the new BD Onclarity HPV assay, which detects E6/E7 DNA from 14 high-risk HPV types, to the Hybrid Capture II (HC2) HPV DNA test, to concurrent cytology and histology results, in order to evaluate its performance in detecting high-grade cervical lesions. A population of 567 women, including 325 with ≥ASCUS (where ASCUS stands for...

  14. Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis

    OpenAIRE

    Matsuda, Katsuya; Miura, Shiro; Kurashige, Tomomi; Suzuki, Keiji; Kondo, Hisayoshi; Ihara, Makoto; Nakajima, Hisayoshi; Masuzaki, Hideaki; Nakashima, Masahiro

    2011-01-01

    Aims A defective DNA damage response can result in genomic instability (GIN) and lead to transformation to cancer. As p53-binding protein 1 (53BP1) localizes at the sites of DNA double strand breaks (DSBs) and rapidly forms nuclear foci (NF), the presence of 53BP1 NF can be considered to be an indicator of endogenous DSBs reflecting GIN. Our aim was to analyse the presence of DSBs by immunofluorescence for 53BP1 expression in a series of cervical lesions, to evaluate the significance of GIN d...

  15. [Unstable traumatic lesions of the lower cervical spine without neurologic deficiency. Our experience at the Fondation Jeanne Ebori in Libreville (Gabon)].

    Science.gov (United States)

    Loembe, P M; Chouteau, Y; Bouger, D

    1991-04-01

    23 cases of unstable traumatic lesions of the lower cervical spine, without neurologic complication, were treated over a period of eight years. These cases consisted of eight dislocations, five subluxations, nine fracture-dislocations and one "tear drop" or fracture of the vertebral body. Six cases were treated conservatively and fifteen operatively. Two patients died in skeletal traction while awaiting surgical intervention. The surgical approaches were anterior (6 cases), posterior (8 cases) and combined (1 case). There was one case of transitory neurologic deficit immediately after surgery. One case required re-intervention. Overall they obtained satisfactory osteoligamentary consolidation. PMID:2055985

  16. Human papillomavirus (HPV detected in restored plasma DNA from women diagnosed with pre-invasive lesions and invasive cervical cancer

    Directory of Open Access Journals (Sweden)

    Edward Fabián Carrillo

    2010-06-01

    Full Text Available Objective: To improve the sensitivity of Human Papillomavirus (HPV detection in plasma from high-grade cervical neoplasia patients (CIN III and cervical cancer (CC evaluating any likely correlation with disease stage.Method: We subjected plasma DNA isolates from 112 patients (CIN and ICC to a pre-PCR restoration treatment to improve detection sensitivity. HPV-specific sequences were detected by conventional PCR both in cervical scrapes and plasma DNA obtained from each patient. For every single DNA sample, both non-restored and restored isolates were PCR analyzed.Results: We detected HPV in plasma DNA isolates with significantly higher efficiency on restored plasma-DNA as compared to each non-restored equivalent, still maintaining close correlation with the clinical stage of the cases. By analyzing plasma-DNA isolates we could classify as HPV positive >50.0% of the cases that were previously known to be positive from the cervical scrape based assay. Interestingly, 100% of the cases in which subtype HPV18 was detected in cervical scrapes were also positive in plasma DNA.Conclusions: Restoration of plasma DNA from cervical cancer patients allows a more sensitive PCR-based HPV detection, maintaining the correlation to disease stage traditionally observed.

  17. Sustainability of abrasive processes

    DEFF Research Database (Denmark)

    Aurich, J.C.; Linke, B.; Hauschild, Michael Zwicky;

    2013-01-01

    This paper presents an overview of research on sustainability of abrasive processes. It incorporates results from a round robin study on ‘‘energy-efficiency of abrasive processes’’ which has been carried out within the scientific technical committee ‘‘abrasive processes’’ (STC G) of CIRP, the...... content of technical presentations in STC G, and the results of a comprehensive literature study. The approach to sustainability includes environmental, social, and economic sustainability in accordance with the definition proposed in the Brundtland Report of the United Nations [156]. The main focus is on...... environmental and social sustainability. Economic sustainability will be considered as manufacturing productivity. © 2013 CIRP....

  18. Research of cervical cytology screening in diagnosis of 370,000 cases with cervical lesion in Guangdong%广东地区37万例妇女子宫颈细胞学筛查子宫颈病变的研究

    Institute of Scientific and Technical Information of China (English)

    Baowen Zheng; Congde Chen; Anxiang Wei; Han Ran; Dong Liu; Wenling Yue; Huirong Zhou; Qingyi Zhu; Juming Su

    2009-01-01

    Objective:Analysis of the results of 37 million cases by using cervical liquid-based cytology screening.discussion the situation of cervical cancer and precancerous lesions in Guangdong province.Methods:From 2002 to 2006.using liquid-based thin-layer cytology (TCT)method screening cervical lesions within 371.929 women in Guangdong.Cytological diagnosis adopt TBS(the Bethesda system)Standard(TBS improved 2001 version of the diagnostic criteria),staastic positive rate by age and region respectively.Results:371,929 cases of gynecology cervical samples in Guangdong.331,251 cases were negative,accounted for 91.23%:cytology positive cases:32,548 cases were squamous intreepithelial lesions(8.96%),486 cases were glandular epithelial lesions(0.13%):grouped according to age:30 to 40-year-old positive rate was 9.13%,40 to 50-year-old positive rate was 9.60%.the latter had higher cytology positive rate;grouped according to region:the total samples in PRD areas were 304.951 cases,accounted for 81.99%,in which 24301 cases were positive(8.14%),in 66978 cases(18.01%)of NON-PRD regions,7645 cases were positive(11.87%),there were 1858 cases had biopsy/follow-up results from 2004t02005.and the rate was 2.88%.Conclusion:The cytological positive rate of cervical cancer and its pre-cancerous lesions was 9.09%in Guangdong(of which the rate of cytological diagnosis as precancerous lesions was 3.40%),30 to 50 age group had the high incidence of cervical cancer and its precursor lesions.and also the main stage of prevention for cervical cancer.Cytology positive rate was 11.87% in economic underdevelopment Non-Pead River Delta regions.much higher than the Pearl River Delta region.

  19. Age trends in the prevalence of cervical squamous intraepithelial lesions among HIV-positive women in Cameroon: a cross-sectional study

    LENUS (Irish Health Repository)

    Atashili, Julius

    2012-10-29

    AbstractBackgroundCervical squamous intra-epithelial lesions (SIL) are more frequent in HIV-positive women overall. However the appropriate age at which to begin and end cervical cancer screening for early detection of lesions in HIV-positive women is not clear. We assessed the age-specific prevalence of any SIL and SIL requiring colposcopy in HIV-positive women in Cameroon.MethodsWe enrolled, interviewed and conducted conventional cervical cytology in 282 women, aged 19--68 years, initiating antiretroviral therapy in three clinics in Cameroon. In bivariable analyses, the crude relationship between age and the presence of lesions was assessed using locally weighted regression (LOWESS) methods. In multivariate analyses, generalized linear models with prevalence as the outcome, an identity link and a binomial distribution, were used to estimate prevalence differences. Bias analyses were conducted to assess the potential effect of inaccuracies in cytology.ResultsSIL were detected in 43.5% of the 276 women with satisfactory samples, 17.8% of whom had ASC-H\\/HSIL. On average, women aged 26 to 59 tended to have a slightly higher prevalence of any SIL than other women (Prevalence difference PD: 6.5%; 95%CI: -11.4, 24.4%). This PD was a function of CD4 count (heterogeneity test p-value =0.09): amongst patients with CD4 counts less than 200cells\\/uL, the prevalence was higher in patients aged 26--59, while there was essentially no difference amongst women with CD4 counts greater than 200 cells\\/uL. ASC-H\\/HSIL were present in women as young as 19 and as old as 62. Overall the prevalence of ASC-H\\/HSIL increased by 0.7% (95%CI: -3.8%, 5.1%) per decade increase in age.ConclusionBoth severe and less severe lesions were prevalent at all ages suggesting little utility of age-targeted screening among HIV-positive women. Nevertheless, the long-term evolution of these lesions needs to be assessed in prospective studies.

  20. The Application Value of Colposcopy Combined with Cervical Cytology in Cervical Lesions%阴道镜检查结合宫颈细胞学在宫颈病变中的应用价值

    Institute of Scientific and Technical Information of China (English)

    王少华

    2014-01-01

    目的:探讨阴道镜检查结合宫颈细胞学在宫颈病变诊治中的临床应用价值。方法随机选在该院接收的656例行阴道镜检查结合宫颈细胞学的妇女作为研究对象,对所有对象的资料进行回顾性分析,总结患者的治疗效果。结果单纯行阴道镜检查筛查3例,无漏诊,癌前期可疑1例。单纯行新柏氏液基细胞学检测检查筛选宫颈癌4例,漏诊1例。行阴道镜检查结合新柏氏液基细胞学检测符合宫颈癌病例5例,无漏诊。结论单纯性阴道镜检查或者新柏氏液基细胞学检测宫颈癌存在漏诊情况,而结合两种方法进行检查后无漏诊现象,即结合两种方法诊断早期宫颈癌有助于提高疾病检出率,值得在临床上推广和使用。%Objective To investigate the clinical application value of colposcopy combined with cervical cytology in the diagnosis and treatment of cervical lesions. Methods 656 cases of women underwent colposcopy combined with cervical cytology in our hos-pital from March, 2012 to March, 2013 were randomly selected as the subjects, and the data of them were analyzed retrospectively, the treatment effect was summarized. Results A simple colposcopy screening 3 cases, no missed diagnosis, pre-cancerous suspi-cious 1 case. Simple ThinPrep liquid-based cervical cytology screening examination in 4 cases, missed 1 case. Colposcopy com-bined with ThinPrep liquid-based cervical cytology in line 5 cases, no missed case. Conclusion Missed diagnosis exists in simple colposcopy or ThinPrep liquid-based cervical cytology for detecting cervical cancer, but that does not exist if combining the two methods for detecting cervical cancer, and the diagnosis of early cervical cancer by combining the two methods is conducive to im-proving the detection rate of the disease, which is worthy of clinical popularization and application.

  1. 人乳头瘤病毒衣壳蛋白与宫颈病变%Human Papillomavirus′ Capsid Proteins and Cervical Lesions

    Institute of Scientific and Technical Information of China (English)

    黄成琳; 张淑兰

    2014-01-01

    Cervical cancer seriously endangers women′s health,and human papillomavirus (HPV) is considered to be the primary cause. Doctors have been striving to find an effective diagnostic method for judging cervical lesions level and predicting its prognosis. HPV capsid proteins comprise the major capsid protein (L1 capsid protein) and the minor capsid protein (L2 capsid protein),and these two proteins play an important role in assembling into virus particles,trafficking HPV to the cell,and causing the host′s immune reactions. In recent years,studies have shown that the L1 capsid protein can be used to predict the progress and subsidence of cervical lesions. HPV prophylactic vaccines ,which are exploited on the basis of the L1 and L2 capsid protein,are proved to get a good preventive effect in clinical trials. This paper reviews the biological characteristics of HPV and researches progress on HPV capsid protein in cervical lesions in recent years.%宫颈癌严重危害妇女健康,人乳头瘤病毒(HPV)感染是其首要病因。临床医师一直致力于寻找一种能有效判断宫颈病变级别及预测预后的诊断方法。 HPV衣壳蛋白包括主要衣壳蛋白(L1壳蛋白)和次要衣壳蛋白(L2壳蛋白),这两种蛋白在组装成病毒颗粒、协助病毒入胞及引起机体免疫反应等多个方面发挥重要作用。近年研究表明, L1壳蛋白可用于预测宫颈病变的进展与消退。以L1及L2壳蛋白为基础研发的HPV预防性疫苗在临床试验中得到了很好的预防效果。综述HPV生物学特点及近年来有关HPV衣壳蛋白在宫颈病变的研究进展。

  2. 人乳头瘤病毒衣壳蛋白与宫颈病变%Human Papillomavirus′ Capsid Proteins and Cervical Lesions

    Institute of Scientific and Technical Information of China (English)

    黄成琳; 张淑兰

    2014-01-01

    宫颈癌严重危害妇女健康,人乳头瘤病毒(HPV)感染是其首要病因。临床医师一直致力于寻找一种能有效判断宫颈病变级别及预测预后的诊断方法。 HPV衣壳蛋白包括主要衣壳蛋白(L1壳蛋白)和次要衣壳蛋白(L2壳蛋白),这两种蛋白在组装成病毒颗粒、协助病毒入胞及引起机体免疫反应等多个方面发挥重要作用。近年研究表明, L1壳蛋白可用于预测宫颈病变的进展与消退。以L1及L2壳蛋白为基础研发的HPV预防性疫苗在临床试验中得到了很好的预防效果。综述HPV生物学特点及近年来有关HPV衣壳蛋白在宫颈病变的研究进展。%Cervical cancer seriously endangers women′s health,and human papillomavirus (HPV) is considered to be the primary cause. Doctors have been striving to find an effective diagnostic method for judging cervical lesions level and predicting its prognosis. HPV capsid proteins comprise the major capsid protein (L1 capsid protein) and the minor capsid protein (L2 capsid protein),and these two proteins play an important role in assembling into virus particles,trafficking HPV to the cell,and causing the host′s immune reactions. In recent years,studies have shown that the L1 capsid protein can be used to predict the progress and subsidence of cervical lesions. HPV prophylactic vaccines ,which are exploited on the basis of the L1 and L2 capsid protein,are proved to get a good preventive effect in clinical trials. This paper reviews the biological characteristics of HPV and researches progress on HPV capsid protein in cervical lesions in recent years.

  3. Detection of Human Papilloma Virus (HPV in oral mucosa of women with cervical lesions and their relation to oral sex practices

    Directory of Open Access Journals (Sweden)

    Martinez-Martinez Alejandro

    2010-12-01

    Full Text Available Abstract Background Previous studies have either investigated the relationship of HPV with oral cancer or the prevalence of HPV on the oral cavity. The purpose of this investigation was to study the prevalence of HPV in oral cavity of women with oral sex practices and cervical lesions. Methods Forty six (46 non-smokers and non-alcoholic patients attended the "Clínica de Displasias" of "Ciudad Juarez" were sampled. This population had a CIN diagnosis sometime between the previous six months. On previous consent they filled out a questionnaire related to their oral sex practices. Afterwards one swab from cheeks and another from palate/gum were taken; PCR was used to determine generic HPV, HPV16 and HPV18. Results Seventy two percent (72% of the patients stated to have oral sex practices regularly which all of them were positive to HPV either in oral mucus, palate/gum or both. The total of the given results showed that 35% had HPV16; among those distributed in 26% with regular oral sex practices and 9% stated as never practiced oral sex. An association was found between oral HPV16 positivity and progression to cervical CIN advanced lesions. On the other hand HPV18 was not detected. The frequency of HPV16 was higher in buccal mucosa (23% versus palate/gum (16%. Conclusions This study suggests that buccal HPV16 infection is associated with CIN progression.

  4. Association of human papillomavirus, Neisseria gonorrhoeae and Chlamydia trachomatis co-infections on the risk of high-grade squamous intraepithelial cervical lesion.

    Science.gov (United States)

    de Abreu, André Lp; Malaguti, Natália; Souza, Raquel P; Uchimura, Nelson S; Ferreira, Érika C; Pereira, Monalisa W; Carvalho, Maria Db; Pelloso, Sandra M; Bonini, Marcelo G; Gimenes, Fabrícia; Consolaro, Marcia El

    2016-01-01

    The link between high-risk human Papillomavirus (HR-HPV) and other sexually transmitted diseases (STDs) in the risk of developing cervical cancer still unclear. Thus, in this report we investigated the rates of co-infections between HPV and other important non-HPV STDs in different cervical findings using a multiplex polymerase chain reaction (M-PCR) to simultaneously detect Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis, HSV-1 and -2, and Treponema pallidum. A total of 838 women aged 18 to 68 years were screened using Papanicolaou smears for cervical abnormalities, HPV and non-HPV STDs using PCR and M-PCR methods. A total of 614 (73.3%) of the women had normal cytology (NILM) and 224 (26.7%) women exhibited abnormal cytology (≥ ASC-US). HPV-DNA prevalence was 33.9%, and HPV-16 was the most prevalent genotype in women with NILM and ≥ ASC-US cytology. Non-HPV STDs were detected in 30.4% women and T. vaginalis was the most prevalent one (11.6%). A higher increased risk of ≥ ASC-US and HSIL occurred in co-infections of HR-HPV with C. trachomatis and N. gonorrhoeae. Co-infections of HPV-DNA and HR-HPV with HSV-2 exhibited a similar increased risk but only with ≥ ASC-US. Co-infections of HPV-DNA and HR-HPV with T. vaginalis demonstrated a similar increased risk of ≥ ASC-US and HSIL. We found that C. trachomatis and N. gonorrhoeae were the primary pathogens associated with HR-HPV for the increased risk for all grades of cervical abnormalities but mainly for HSIL, suggesting a possible synergistic action in cervical lesions progression. Our results reinforce the hypothesis that some non-HPV STDs might play a role as co-factors in HPV-mediated cervical carcinogenesis. These data improve our understanding of the etiology of SCC and may also be useful for disease prevention. PMID:27429850

  5. The SNP at −592 of human IL-10 gene is associated with serum IL-10 levels and increased risk for human papillomavirus cervical lesion development

    Directory of Open Access Journals (Sweden)

    Torres-Poveda Kirvis

    2012-11-01

    Full Text Available Abstract Background Women with Human Papilloma Virus (HPV persistence are characterized by high levels of IL-10 at cervix. We have determined whether polymorphisms of IL-10 gene promoter might be associated with increased risk of squamous intraepithelial cervical lesions (SICL and whether exist significative differences of IL-10 mRNA expression at cervix and systemic and serum IL-10 protein between SICL cases and non-Cervical Lesions (NCL. Methods Peripheral blood samples from SICL (n = 204 and NCL (n = 166 were used to detect IL-10 promoter polymorphisms at loci -592A/C (rs1800872, -819C/T (rs1800871, -1082A/G (rs1800896, -1352A/G (rs1800893, by allelic discrimination and to evaluate serum IL-10 protein. Cervical epithelial scrapings from NCL and biopsies from SICLs were used for HPV-typing and to evaluate IL-10 mRNA expression level. The systemic and local IL-10 mRNA expression levels were measured by real time-PCR. Genotypic and allelic frequencies of the selected polymorphisms were analyzed by logistic regression, adjusting by age and HPV-genotype, to determine the association with SICL. Results No significant differences were found between genotype frequencies at loci −819, -1082, and −1352. Individuals carrying at least one copy of risk allele A of polymorphism −592 had a two-fold increased risk of developing SICL [adjusted odds ratio (OR, 2.02 (95% CI, 1.26-3.25, p = 0.003], compared to NCL. The IL-10 mRNA expression and serum IL-10 protein, were significantly higher in SICL cases (p  Conclusions The −592 polymorphism is associated with increased risk of SICL and can serve as a marker of genetic susceptibility to SICL among Mexican women. According to IL-10 levels found in SICL, IL-10 can be relevant factor for viral persistence and progression disease.

  6. High risk human papillomavirus type 16 and 18 infection in the cervical lesions of women with epithelial cell abnormality in Pap smear: A cytohistomorphologic association in Bangladeshi women

    Directory of Open Access Journals (Sweden)

    Urmila Banik

    2013-01-01

    Full Text Available Background: The aim of this study was to find out the extent of high-risk human papillomavirus (hrHPV type 16/18 infection in the cervical tissue of women with epithelial cell abnormality in Pap smear and to establish an association between hrHPV type 16/18 infection and cytohistomorphology. Materials and Methods: A cross-sectional descriptive study was carried out in 1699 patients who went through Pap smear examination. Prevalence of epithelial cell abnormality was calculated. Forty eight of these women underwent routine histopathology and 47 were evaluated for human papillomavirus (HPV type 16/18 by polymerase chain reaction assay. Results: Total 139 women revealed epithelial cell abnormality. Histopathology showed simple inflammation to malignancy. HPV type 16/18 infection was detected in 40.42% (19/47 of the patients. Individually type 16 and 18 were positive in 7 (14.9% cases each and dual infection with type 16 and 18 were seen in 5 (10.6% cases. While cervical intraepithelial neoplasia grade 1 (CIN 1 and < CIN 1 lesions showed 18.75% (3 out of 16 and 35% (7 out of 20 positivity respectively, ≥CIN 2 lesions revealed positivity of 81.82% (9 out of 11. Eighty percent HPV 16/18 positivity was seen in women of < 30 years of age. Conclusion: The findings of this study will contribute to HPV 16/18 knowledge in Bangladesh that will be useful in assessing the success of current vaccines with limited type spectra and augmenting cervical cancer screening strategies.

  7. Risk of progression of early cervical lesions is associated with integration and persistence of HPV-16 and expression of E6, Ki-67, and telomerase

    Directory of Open Access Journals (Sweden)

    Arianna Vega-Peña

    2013-01-01

    Full Text Available Background: Low-grade squamous intraepithelial lesions (LSIL are the earliest lesions of the uterine cervix, the persistence and integration of high-risk human papillomavirus (HR-HPV as type 16, which promotes the development of more aggressive lesions. Aim: To select more aggressive lesions with tendency to progress to invasive cervical cancer. Materials and Methods: A total of 75 cytological specimens in liquid base (Liqui-PREP were analyzed: 25 specimens were with no signs of SIL (NSIL and without HPV; 25 NSIL with HPV-16, and 25 with both LSIL and HPV-16. The expression of Ki-67, telomerase, and viral E6 was evaluated by immunocytochemistry; and the detection of viral DNA was done by polymerase chain reaction (PCR and restriction fragment length polymorphism (RFLPs for genotyping or sequencing of HPV-16. The physical state of HPV-16 was evaluated by in situ hybridization with amplification with tyramide. Results: Of the total group, 58.6% had LSIL associated with persistence and of these 59.3% was associated with integrated state of HPV as intense expression of E6, Ki-67 (P = 0.013, P = 0.055 has except for the expression of telomerase present a non-significant association (P<0.341. Conclusions: Overexpression of E6 and Ki-67 is associated with the integration of HPV-16, favoring viral persistence, and increasing the risk of progression in women with NSIL and LSIL.

  8. Characterization of High Grade Intraepithelial Cervical Lesion among Adolescents and Young Women Caracterización de las lesiones intra-epiteliales cervicales de alto grado en adolescentes y mujeres jóvenes

    Directory of Open Access Journals (Sweden)

    Carlos Eric Daudinot Cos

    2011-11-01

    Full Text Available Introduction: considering the relationship between human papilomavirus and cervical cancer, the current increase in sexually transmitted diseases constitutes the biggest threaten to adolescents’ health. Objective: to characterize high-degree intraepithelial cervical lesion in adolescents and young women. Method: a descriptive and observational study was conducted. It included 52 patients, all of them younger than 24 years old, who had been diagnosed with high-degree cervical pathology and were treated in the cervix pathology consultation of the "Ramón González Coro" Teaching Gynecologic and Obstetric Hospital from January 2007 to December 2008. Risk factors and diagnosis variables were studied and processed using the SPSS 11.5 system for Windows, through the determination of absolute and relative frequencies. Results: 78,8 % of patients had from 20 to 24 years old, 65,3 % of them began having sexual relationships between 15 and 17 years old, 62,2 % had had 3 or more sexual partners and 67,3 % used no contraceptive method. Cyto- histological correlation was of 100 % for intraepithelial cervical lesion II and III. Conclusion: the results of the present study compromise us to highlight the need of extended sexual education among young people.Introducción: el actual incremento de las Infecciones de Transmisión Sexual constituye la mayor amenaza para la salud de los adolescentes, si se conoce la asociación del Virus del Papiloma Humano con el cáncer cervical. Objetivo: caracterizar las lesiones intra-epiteliales cervicales de alto grado en adolescentes y mujeres jóvenes. Método: estudio observacional, descriptivo, en 52 pacientes menores de 24 años con diagnostico de lesión cervical de alto grado, atendidas en la consulta de patología de cuello del Hospital Ginecobstétrico ¨Ramón González Coro¨, de

  9. 薄层液基细胞学在宫颈癌及其癌前病变筛查中的价值%The value of Thin prep cytology test in cervical precancerous lesions and cervical cancer screening

    Institute of Scientific and Technical Information of China (English)

    雷静; 万霖; 李惠新; 蒋瑛; 李瑞萍

    2011-01-01

    Objective: To evaluate the detecting technology of thin layers of liquid base cytology (TCT) on the diagnosis of precancerous lesions of uterine cervix and the clinical value, accuracy of the cervical cancer screening. Methods: To collect and analysis 7340 patients who were did examine of TCT in gynecological clinic line of our hospital from May, 2009 ~ November, 2010. Take cytology diagnosed ASC - US and higher as positive results, and the positive results do pathohistological. Take histological diagnosis as gold standard. Results: Thin prep cytology test specimens of SCC, and satisfaction LSIL accuracy HSIL, respectively, 76.8% 97.3%, 100%. Conclusion: TCT combination diagnostic systems of TBS are ideal method of current diagnosis precancerous lesions of uterine cervix (CIN) and cervical cancer screening. Also it can be used as an indicator for cervical cancer detecting. There is some risk of precancerous lesions of young In ASC-US patients.%目的:评价薄层液基细胞学(Thin prep cytology test,TCT)检测技术对宫颈癌前病变的诊断和宫颈癌筛查的准确性及临床价值.方法:收集分析2009年5月~2010年11月在我院妇科门诊行TCT检查的受检者7340例,以细胞学诊断为未明确意义的不典型鳞状上皮细胞(ASC-US)及以上者为阳性结果,并对阳性结果行病理组织学诊断,以组织学诊断作为金标准.结果:液基细胞学标本满意度高,对SCC、HSIL、LSIL的准确率分别为76.8%、97.3%、100%.结论:TCT结合TBS诊断系统是目前诊断宫颈癌前病变和筛查宫颈癌的理想方法 [1],同时也可以作为一项宫颈癌术后随访的检测指标 [2].ASC-US患者中存在部分年轻的高危癌前病变者.

  10. Dermoscopy and Onychomycosis: guided nail abrasion for mycological samples*

    Science.gov (United States)

    Bet, Diego Leonardo; dos Reis, Ana Lucia; Chiacchio, Nilton Di; Belda Junior, Walter

    2015-01-01

    Mycological examination is still the cornerstone for the diagnosis of onychomycosis for many dermatologists, but sampling technique interferes on its sensitivity and specificity. Nail abrasion may be used to reach the most proximal part of the lesion and can be easily accomplished with an electric abrasor. We suggest nail plate dermoscopy to identify the best location for localized abrasion to obtain adequate samples for mycological examination. PMID:26734877

  11. Investigation of non-carious cervical lesions of populations in Guangzhou area%广州市中高收入人群楔状缺损调查分析

    Institute of Scientific and Technical Information of China (English)

    闫文娟

    2012-01-01

    Objective To survey the prevalence, characteristics of non-carious cervical lesion and analyze its relationship with life style. Methods Eight hundred and eighty-five subjects including 490 males and 395 females who underwent oral health assessment in Nanfang hospital were surveyed. The shape, size, location of non-carious cervical lesion , tooth brushing habits, hand preference and bruxism were recorded for analysis. Results Non-carious cervical lesions were found in 76. 61% of subjects without gender difference. 70.17% affected teeth demonstrated v-shape lesion. Non-carious cervical lesions were mostly on posterior maxillary teeth and first premolars (34.29% ) were mostly affected. Non-carious cervical lesions were more common in right-hand tooth brusher. Senior patients were more likely to have non carious cervical lesions. Conclusion The prevalence of non-carious cervical lesions in Guangzhou area was high and the knowledge on this disease need to be improved.%目的 调查广州市部分中高收入人群的牙颈部楔状缺损患病率、病变特征及病因,为制定楔状缺损防治措施提供依据.方法 对885名中高收入人员楔状缺损状况进行调查,以楔状缺损牙数、缺损形状、好发牙位、刷牙方式等情况作为统计指标,对所得数据进行统计学分析.结果 该人群楔状缺损患病率为76.61%,男女差异无统计学意义(P>0.05);70.17%的楔状缺损为V形,主要发生在上颌后牙,以上颌第一前磨牙最常见,患病率为34.29%.年龄越大、习惯横向刷牙及爱吃硬食的人,楔状缺损患病率更高.调查人群中楔状缺损的就诊率为20.64%.结论 广州市部分中高收入人群的楔状缺损患病率较高,有喜欢吃硬食、横向刷牙等不良习惯的人群患病率更高.

  12. Cervical Liquid-based Cytology in Cervical Lesions the Pathological Diagnosis of Significance%宫颈液基薄层细胞学在宫颈病变病理诊断中的意义

    Institute of Scientific and Technical Information of China (English)

    郑国文

    2013-01-01

      Objective To investigate the liquid-based cytology (TCT) value in pathological diagnosis of cervical lesions. Methods Retrospective analysis of 2009 January to 2012 June, 5795 patients with TCT cervical cytology, colposcopy biopsy positive cases, compared the two results. Results In 5499 cases of TCT were negative, 296 cases were positive, the positive rate was 5.11%, false negative in 15 cases, no false positive cases. 17 cases of biopsy tissue inflammation, 224 cases of CIN Ⅰ, 20 cases of CINⅡ, 30 cases of CINⅢ, CA 5 cases, LSIL and CIN Ⅰcoincidence rate was 80% (36/45), HSIL and CINⅡ/Ⅲcoincidence rate was 88.9% (24/27). Conclusion TCT examination has a little injury, high positive rate, strong repeatability, for married women can be used as the main method of screening for cervical cancer and precancerous lesions.%  目的探讨液基薄层细胞学(TCT)检查在宫颈病变病理诊断中的意义。方法回顾分析我院2009年1月至2012年6月5795例患者运用 TCT 进行宫颈脱落细胞学检查,阳性病例在阴道镜下活检,二者结果相比较分析。结果 TCT 检查阴性5499例,阳性296例,阳性率5.11%,假阴性15例,无假阳性病例。组织活检炎症17例,CIN Ⅰ224例,CIN Ⅱ20例,CIN Ⅲ30例,CA 5例,LSIL 与 CIN Ⅰ符合率80.0%(36/45),HSIL 与 CIN Ⅱ/Ⅲ符合率88.9%(24/27)。结论 TCT 检查具有损伤小,阳性检出率高,重复性强,对已婚妇女可作为宫颈癌及癌前病变筛查的主要方法。

  13. Prevalence of human papillomavirus types in women with pre-neoplastic and neoplastic cervical lesions in the Federal District of Brazil

    Directory of Open Access Journals (Sweden)

    Geni NL Camara

    2003-10-01

    Full Text Available As a contribution to the public health authorities in planning prophylactic and therapeutic vaccine strategies, we describe the prevalence of human papillomavirus (HPV types in women presenting abnormal cytological results in Pap smear screening tests in the Federal District, Central Brazil. We studied 129 cervical scraping samples from women whose cytological tests showed either pre-neoplastic or neoplastic lesions. Amplification of HPV DNA was performed by polymerase chain reaction using consensus primers MY09 and MY11 followed by identification of isolates by restriction fragment length polymorphism. We detected HPV DNA in 62% of the samples, including HPV-16 in 43.8%, HPV-58 in 12.5%, HPV-31 in 10%, HPV-53 in 6.3%, each of HPV-18 and HPV-33 in 3.8% of the isolates. Other types (HPV-35, -52, -66, -CP8304, -6, -11, and -CP8061 were less frequent (= or < 2.5% each. The prevalence of HPV-58 was relatively higher in this population than in data in South America, but similar to results obtained in other studies in Latin America, Europe, and Eastern Asia. Case-control studies need to be carried out to establish the association between the prevalence of HPV types specially the less frequent high-risk types and cervical cancer.

  14. Study to assess the acceptability and feasibility of cervical cancer screening using visual inspection with acetic acid and treatment of precancerous lesions using cryotherapy in low resource settings

    Directory of Open Access Journals (Sweden)

    Tosha M. Sheth

    2014-06-01

    Full Text Available Background: Objective of current study was to assess the acceptability and feasibility of cervical cancer screening using VIA, and treatment of precancerous lesions using cryotherapy in low resource settings Methods: 526 women from three primary health centers of Shinor taluka (population based approach and 250 women of Medical College, Vadodara (facility based approach were sensitized and screened for cervical cancer. Visual Inspection with Acetic acid (VIA was performed as the screening test. In the population based approach, VIA positive women were referred to a Community Health Centre (CHC for colposcopy and biopsy. Ablative treatment in the form of cryotherapy was offered. Patients requiring higher forms of treatment were referred to medical college, Vadodara. In the facility based approach, VIA positive women underwent colposcopy. Guided biopsy was performed in those with positive lesions on colposcopy. Cryotherapy was offered in the same sitting. Those not suitable for cryotherapy were offered loop electrosurgical excision procedure. Women found to have invasive cancer were offered definitive management. Results: VIA positivity rate was 18.8% in the population based approach and 27.2% in the facility based approach.58.8% women in the population based approach and 77.77% women in the facility based approach were treated with cryotherapy on the same day as screening and none reported any severe side effects. Dropout rate in the community approach was 32.32% whereas in the facility it was 0.4%. Conclusions: VIA and cryotherapy procedures were well tolerated by all screened women. This project has shown that the and ldquo;screen and treat and rdquo; approach can be successfully implemented in the existing health setup. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 615-621

  15. Primary (recurrent) and metastatic lesions detection in cervical cancer: A comparison of positron emission tomography, CT and/or MRI image and pathological study

    International Nuclear Information System (INIS)

    Aim: This prospective study is to compare the results of primary (recurrence) and metastatic lesions detection, based on pathologic results, with computed tomography (CT) and/or magnetic resonance imaging (MRI) and positron emission tomography (PET) with [18F]-fluoro-2-deoxy-D-glucose (FDG) in invasive cervical cancer (ICC). Materials and Methods: An FDG PET scan was performed in 136 patients with ICC (107 squamous cell carcinoma [SCC], 18 adenocarcinoma [AdenoCa], 5 adeosquamous cell carcinoma, 4 small cell carcinoma, and 2 poorly differentiated carcinoma; from FIGO staging IB to IVB prior to operation). CT and/or MRI image were performed within one week before or after FDG PET scan was done. The accuracy of lymph node status was based on histological result or a second FDG PET combined with a CT and/or MRI image images. Results: Totally, 68 main tumor and 147 metastatic lesions were recognized by either histopathology or a follow up study. On a lesion basis, CT and/or MRI image images demonstrated 63 (92.6 %) main tumor and 103 (70.1 %) metastatic lesions. For lymph node metastatic lesions detection, there were 6(75 %) enlarged inguinal lymph nodes, 38(76 %) enlarged pelvic lymph nodes (PLN), 28(73.7 %) enlarged para-aortic lymph nodes (PAN), 8(50 %) enlarged supraclavicular lymph nodes (SLNs), and 5(62.5 %) enlarged mediastinal lymph nodes (MLNs). Liver metastases were found in 4(100 %), in lung in 7(70 %) and in bone in 5(83.3 %). Peritoneal metastases were found in 2(28.6 %). FDG PET demonstrated 63 (92.6 %) and 135 (91.8 %) metastatic lesions. For lymph node metastases, FDG PET found 8(100 %) enlarged inguinal lymph nodes, 44(88 %) enlarged PLNs, 36(94.7 %) enlarged PANs, 15(93.8 %) enlarged SLNs, and 8(100 %) enlarged MLNs. Liver metastases were found in 4(100 %), in lung in 9(90 %) and in bone in 6(100 %). Peritoneal metastases were found in 5(71.4 %). On a patient basis, with FDG PET scan, 31(22.8%) were upstaging while 4(2.9%) were down staging. 35

  16. Loss of Dependence on Continued Expression of the Human Papillomavirus 16 E7 Oncogene in Cervical Cancers and Precancerous Lesions Arising in Fanconi Anemia Pathway-Deficient Mice.

    Science.gov (United States)

    Park, Soyeong; Park, Jung Wook; Pitot, Henry C; Lambert, Paul F

    2016-01-01

    Fanconi anemia (FA) is a rare genetic disorder caused by defects in DNA damage repair. FA patients often develop squamous cell carcinoma (SCC) at sites where high-risk human papillomaviruses (HPVs) are known to cause cancer, including the cervix. However, SCCs found in human FA patients are often HPV negative, even though the majority of female FA patients with anogenital cancers had preexisting HPV-positive dysplasia. We hypothesize that HPVs contribute to the development of SCCs in FA patients but that the continued expression of HPV oncogenes is not required for the maintenance of the cancer state because FA deficiency leads to an accumulation of mutations in cellular genes that render the cancer no longer dependent upon viral oncogenes. We tested this hypothesis, making use of Bi-L E7 transgenic mice in which we temporally controlled expression of HPV16 E7, the dominant viral oncogene in HPV-associated cancers. As seen before, the persistence of cervical neoplastic disease was highly dependent upon the continued expression of HPV16 E7 in FA-sufficient mice. However, in mice with FA deficiency, cervical cancers persisted in a large fraction of the mice after HPV16 E7 expression was turned off, indicating that these cancers had escaped from their dependency on E7. Furthermore, the severity of precancerous lesions also failed to be reduced significantly in the mice with FA deficiency upon turning off expression of E7. These findings confirm our hypothesis and may explain the fact that, while FA patients have a high frequency of infections by HPVs and HPV-induced precancerous lesions, the cancers are frequently HPV negative. IMPORTANCE  : Fanconi anemia (FA) patients are at high risk for developing squamous cell carcinoma (SCC) at sites where high-risk human papillomaviruses (HPVs) frequently cause cancer. Yet these SCCs are often HPV negative. FA patients have a genetic defect in their capacity to repair damaged DNA. HPV oncogenes cause an accumulation of DNA

  17. Application research of HPV test in screening of cervical lesions%HPV检测在宫颈病变筛查中的应用价值研究

    Institute of Scientific and Technical Information of China (English)

    揭艳频

    2014-01-01

    目的:探讨HPV检测在宫颈病变筛查中的应用价值。方法选择2011年2月-2013年6月本院门诊及体检的500例女性HPV检测的患者,分别给予HPV的TCT和DNA检测,并于病理组织检查结果进行比较。结果随着病变等级的升高, HPV DNA感染率逐渐升高。 TCT检测的阳性率为15.4%,HPV DNA检测的阳性率为35.2%,病理检测的阳性率为19.6%;TCT检测的灵敏度为44.90%,HPV DNA检测的灵敏度为83.67%,两组间差异有统计学意义(P<0.05)。结论 HPV DNA检测的灵敏度高于TCT检测,但两者各有优势,在宫颈病变筛查中的应用价值较高。%Objective To explore the application of HPV test in screening of cervical lesions. Methods 500 cases of female pa-tients with HPV tested in our hospital outpatient service and the physical examination from February 2011 to June 2013were se-lected, they were given the HPV TCT and DNA tested respectively, the examination results was compared with histopathologic. Results With the increase of level of lesion, the HPV DNA infection rate increased. TCT detection positive rate was 15.4%, HPV DNA detection positive rate was 35.2%, the pathological d detection positive rate was 19.6%;TCT detection sensitivity of 44.90%, the HPV DNA sensitivity of 83.67%, the differences between the two groups was statistically significant (P<0.05). Conclusion HPV DNA detection sensitivity is higher than the TCT detection, but they have their own advantages and high application value in screening of cervical lesions.

  18. Research progress in relationship between HPV testing and diagnosis and treatment of cervical lesions%HPV检测在宫颈疾病诊治中的研究进展

    Institute of Scientific and Technical Information of China (English)

    景笑笑; 杨雪峰

    2012-01-01

    Cervical cancer is the most common malignant tumor in female reproductive system, and its etiology is not entirely clear. Currently it is accepted that cervical cancer is related with human papilloma virus ( HPV ) infection. The persistent high - risk HPV infection is the main cause of cervical lesions. The detecting and therapy of high-risk HPV has become an important means in screening precancerous cervical diseases and preventing cervical cancer. This article summarized the relationship between HPV infection and cervical lesions, relationship between HPV viral load and classification and severity of cervical disease, the clinical value of HPV in evaluating therapeutic efficacy, judging prognosis and guiding cytology positive patients in shunt aspects and HPV vaccine.%宫颈癌是女性生殖系统最常见的恶性肿瘤,其发病原因尚未完全清楚,目前公认宫颈癌的发病与人乳头瘤病毒(HPV)感染有关,持续的高危型HPV感染是引起宫颈病变的主要病因,对高危型HPV的检测和治疗已成为筛查宫颈癌前病变、预防宫颈癌的重要手段.该文围绕HPV感染与宫颈病变的关系,HPV病毒载量、分型与宫颈病变严重程度的关系以及其在评估治疗效果、判断预后、指导细胞学阳性患者分流等方面的临床价值,HPV疫苗等的研究进展作以综述.

  19. Comparison of Onclarity Human Papillomavirus (HPV) Assay with Hybrid Capture II HPV DNA Assay for Detection of Cervical Intraepithelial Neoplasia Grade 2 and 3 Lesions.

    Science.gov (United States)

    Bottari, F; Sideri, M; Gulmini, C; Igidbashian, S; Tricca, A; Casadio, C; Carinelli, S; Boveri, S; Ejegod, D; Bonde, J; Sandri, M T

    2015-07-01

    Analytical and clinical performance validation is essential before introduction of a new human papillomavirus (HPV) assay into clinical practice. This study compares the new BD Onclarity HPV assay, which detects E6/E7 DNA from 14 high-risk HPV types, to the Hybrid Capture II (HC2) HPV DNA test, to concurrent cytology and histology results, in order to evaluate its performance in detecting high-grade cervical lesions. A population of 567 women, including 325 with ≥ASCUS (where ASCUS stands for atypical cells of undetermined significance) and any HC2 result and 242 with both negative cytology and negative HC2 results, were prospectively enrolled for the study. The overall agreement between Onclarity and HC2 was 94.6% (95% confidence intervals [CI], 92.3% to 96.2%). In this population with a high prevalence of disease, the relative sensitivities (versus adjudicated cervical intraepithelial neoplasia grades 2 and 3 [CIN2+] histology endpoints) of the Onclarity and HC2 tests were 95.2% (95% CI, 90.7% to 97.5%) and 96.9% (95% CI, 92.9% to 98.7%), respectively, and the relative specificities were 50.3% (95% CI, 43.2% to 57.4%) for BD and 40.8% (95% CI, 33.9%, 48.1%) for HC2. These results indicate that the BD Onclarity HPV assay has sensitivity comparable to that of the HC2 assay, with a trend to an increased specificity. Moreover, as Onclarity gives the chance to discriminate between the different genotypes, we calculated the genotype prevalence and the absolute risk of CIN2+: HPV 16 was the most prevalent genotype (19.8%) with an absolute risk of CIN2+ of 77.1%. PMID:25903574

  20. Clinical significance of Thinprep cytology test in screening of cervical lesions%液基薄层细胞学在筛查宫颈病变中的临床意义

    Institute of Scientific and Technical Information of China (English)

    张江菊; 黄寅虎; 郭建新; 李力; 郑秀惠

    2013-01-01

    Objective:To explore the clinical significance of Thinprep cytology test (TCT) in screening of cervical lesions.Methods:TCT screening was conducted among 18 904 patients from outpatient department of Daping Hospital Affiliated to the Third Military Medical University from January to December in 2012,and 688 patients were found with cytological abnormalities (diagnosis of TBS system ≥ ASC-US),then 416 patients underwent colposcopy and biopsy ; the clinical significance of TCT in screening of cervical lesions was evaluated with pathological examination as gold standard.Results:A total of 416 patients were found with cytological abnormalities,including 195 patients with ASC,65 patients with LSIL,138 patients with HSIL,and 52 patients with cervical cancer; 128 patients with cervicitis,106 patients with cervical intraepithelial neoplasia (CIN) Ⅰ,78 patients with CIN Ⅱ,52 patients with CIN Ⅲ,and 52 patients with cervical invasive carcinoma (including one patient with cervical adenocarcinoma) were found by pathological examination; the coincidence rates of diagnosis between pathological examination and TCT were 48.21% (ASC),81.54% (LSIL),89.13% (HSIL),and 100.00% (cervical cancer),respectively; the sensitivity and specificity of TCT for cervical lesions (≥ CIN Ⅱ) were 90.66% and 76.07%,respectively.Conclusion:TCT can improve the detection rate of cervical lesions and it has a high concordance with the histopathological results with high sensitivity,TCT is an effective method for screening cervical lesions and missed diagnosis can be reduced.%目的:探讨液基薄层细胞学在筛查子宫颈病变中的临床意义.方法:对2012年1月~12月第三军医大学大坪医院18 904例门诊患者进行TCT筛查,发现细胞学异常(TBS系统诊断≥ASC-US)的患者688例,其中416例进行了阴道镜检查并取活检,以病理学为标准,评价TCT筛查子宫颈病变的临床意义.结果:细胞学异常的416例患者中,ASC 195例,LSIL65

  1. Human Papillomavirus and Cervical Cancer

    OpenAIRE

    D. Jenkins(University of York, UK)

    2003-01-01

    Of the many types of human papillomavirus (HPV), more than 30 infect the genital tract. The association between certain oncogenic (high-risk) strains of HPV and cervical cancer is well established. Although HPV is essential to the transformation of cervical epithelial cells, it is not sufficient, and a variety of cofactors and molecular events influence whether cervical cancer will develop. Early detection and treatment of precancerous lesions can prevent progression to cervical cancer. Ident...

  2. Three-year clinical performance of a HEMA-free one-step self-etch adhesive in non-carious cervical lesions.

    Science.gov (United States)

    Van Landuyt, Kirsten L; Peumans, Marleen; De Munck, Jan; Cardoso, Marcio V; Ermis, Banu; Van Meerbeek, Bart

    2011-12-01

    Despite the fact that one-step adhesives are currently used routinely in clinical practice, long-term studies on their clinical performance are scarce. The objective of this randomized controlled clinical trial was to test the hypothesis that a 2-hydroxyethyl methacrylate (HEMA)-free one-step self-etch adhesive performs worse than a conventional multistep etch-and-rinse adhesive. Two-hundred and seventy-six non-carious cervical lesions in 52 patients were restored with a micro-hybrid composite (Gradia Direct; GC). These restorations were bonded in random order either with the HEMA-free one-step adhesive G-Bond (GC) or with the 'gold-standard' (control) three-step adhesive Optibond FL (Kerr). The restorations were evaluated after 6, 12, 24, and 36 months of clinical service regarding retention, marginal adaptation, microleakage, caries occurrence, and sensitivity. After a medium-long period of 3 yr, similar success in clinical performance was observed for the simplified all-in-one adhesive and the conventional three-step adhesive. However, the one-step adhesive exhibited significantly more incisal marginal defects and discolorations. Whereas marginal degradation appeared to arrest for the multistep etch-and-rinse adhesive after 12 months, the enamel margins of the restorations bonded with the one-step self-etch adhesive continued to deteriorate. These incisal marginal defects were, however, small and could easily be removed by polishing. For both adhesives, large and sclerosed lesions appeared to be at higher risk of retention loss. PMID:22112039

  3. Application of liquid -based cytology with colposcopy in diagnosis of cervical lesions%液基细胞学结合阴道镜检查在诊断宫颈病变中的应用

    Institute of Scientific and Technical Information of China (English)

    周晓花

    2011-01-01

    Objective To explore and evaluate the liquid -based cytology(TCT) and colposcopy for cervical lesions.Methods The diagnostic criteria for pathological results in our hospital colposcopy, biopsy and the cervical lesions TCT test results were analyzed.Results TCT compared with the biopsy tissue, benign coincidence rate was 98.4% , LSIL, HSIL, cancer diagnosis rate was 85.4% ,97% and 100%; Colposcopy compared with histologica findings, CIN or more colposcopy cervical lesions was 97.8% compliance.Conclusions TCT consistent with colposcopy was no significant difference( P > 0.05 ), application of TCT assisted colposcopy can improve cervical lesions and cancer detection rate.%目的 探讨和评价液基细胞学(TCT)结合阴道镜对宫颈病变的诊断价值.方法 以病理学结果为诊断标准,对在永城市人民医院进行阴道镜、活检及TCT的宫颈病变患者的检查结果进行分析.结果 TCT与活检病理组织学相比,良性符合率为98.4%,LSIL、HSIL、癌的诊断符合率分别为85.4%、97%和100%;阴道镜检查结果与组织学相比,CIN以上的宫颈病变阴道镜符合率为97.8%.结论 TCT与阴道镜检查符合率无统计学意义(P>0.05),应用TCT辅助阴道镜检查可提高宫颈癌前病变和癌变的检出率.

  4. 多种HPV亚型检测在宫颈病变诊治中的意义%Significances of detections of multiple human papillomavirus subtypes in diagnosis and treatment of cervical lesions

    Institute of Scientific and Technical Information of China (English)

    李娟; 尹格平; 陈铭; 朱彤宇; 崔晓宁; 提松梅

    2012-01-01

    目的:通过研究不同HPV亚型与宫颈病变之间的关系,为宫颈病变的筛查和防治提供理论基础.方法:采用导流杂交基因芯片技术对1 430例宫颈病变患者进行21种HPV亚型检测,包括16种高危亚型(HR - HPV)和5种低危亚型(LR- HPV),对阳性患者行宫颈多点活体组织检查(活检),以组织病理学诊断作为宫颈病变确诊的金标准.结果:①1 430例宫颈病变患者中检测到HPV阳性患者210例,阳性率为14.68%,其中,感染HR - HPV 174例(82.86%),感染LR - HPV 36例(17.14%);居前6位的感染亚型是:HPV 16 (43.81%)、52 (15.71%)、11 (10.00%)、58 (8.57%)、31 (7.62%)、33(7.14%).其中单一感染176例(83.81%),多重感染34例(16.19%).②HR - HPV感染致CIN和宫颈癌的发病率明显高于LR - HPV; HR - HPV的感染率随宫颈病变程度的加重而逐渐增高,其中,宫颈癌组HR - HPV感染率与对照组比较差异有统计学意义(P<0.05).③宫颈癌组HPV多重感染率与对照组比较差异有统计学意义(P<0.05).结论:不同HPV亚型感染可导致不同的宫颈病变,并且与宫颈病变的不同程度密切相关.HPV多重感染与宫颈癌的发病密切相关.多种HPV亚型检测在宫颈病变筛查和防治过程中具有重要意义.%Objective: To provide theoretical basis for screening, prevention, and treatment of cervical lesions by investigating the relationship between different human papillomavirus ( HPV) subtypes and cervical lesions. Methods; Flow - through hybridization gene chip technique was used to detect 21 kinds of HPV subtypes among 1 430 patients with cervical lesions, 16 kinds of high risk HPV subtypes and 5 kinds of low risk HPV subtypes were included, the positive patients received multiple punch cervical biopsy, histopathological diagnosis was used as gold standard of cervical lesions. Results; Among 1 430 patients with cervical lesions, 210 patients were found with HPV, the positive rate was 14. 68

  5. Abrasion resistant tubular member

    International Nuclear Information System (INIS)

    A surface of a tubular member made of an austenite stainless steel having a molybdenum content of from 2 to 3% is subjected to a low temperature ionization nitriding treatment in a gas atmosphere of N2: from 5 to 15% by volume, H2: from 95 to 85% by volume, at a temperature of from 400 to 470degC to form a nitride layer. Since the low temperature ion nitriding treatment is thus applied, generation of ε phase which lowers corrosion resistance can be suppressed. That is, the hardened layer (nitride layer) is provided with abrasion resistance, while the inside can keep the inherent characteristic of the austenite stainless steel having high toughness. In addition, this can avoid the tendency of lowering corrosion resistance due to the formation of a ε phase caused by exposure to high temperature for a long time in order to increase the thickness of the nitrided layer. When the thickness of the tube is 1.3mm, the less than 130μm is enough for the nitride layer. Abrasion resistance can be improved by thus applying ion nitriding treatment to the austenite stainless steel containing molybdenum under controlled temperature and atmosphere. (N.H.)

  6. Clinical effectiveness of a one-step self-etch adhesive in non-carious cervical lesions at 2 years.

    Science.gov (United States)

    Ermis, R Banu; Van Landuyt, Kirsten L; Cardoso, Marcio Vivan; De Munck, Jan; Van Meerbeek, Bart; Peumans, Marleen

    2012-06-01

    A 2-year randomized, controlled prospective study evaluated the clinical effectiveness of a one-step self-etch adhesive and a "gold-standard" three-step etch-and-rinse adhesive in non-carious Class-V lesions. The null hypothesis tested was that the one-step self-etch adhesive does perform clinically equally well as the three-step etch-and-rinse adhesive. A total of 161 lesions in 26 patients were restored with Clearfil AP-X (Kuraray). The restorations were bonded either with the "all-in-one" adhesive Clearfil S3 Bond (Kuraray) or with the three-step etch-and-rinse adhesive Optibond FL (Kerr). The restorations were evaluated at baseline and after 6 months, 1 and 2 years, regarding their retention, marginal adapation, marginal discoloration, caries occurrence, preservation of tooth vitality and post-operative sensivity. Retention loss, severe marginal defects and/or discoloration that needed intervention (repair or replacement) and the occurrence of caries were considered as clinical failures. The recall rate at 2 years was 93.8%. Only one Clearfil S3 Bond restoration was lost at the 2-year recall. All other restorations were clinically acceptable. The number of restorations with defect-free margins decreased severely during the 2-year study period (to 6.7% and 25.3% for Clearfil S3 Bond and Optibond FL, respectively). The Clearfil S3 Bond restorations presented significantly more small marginal defects at the enamel side than the Optibond FL restorations (Clearfil S3 Bond: 93.3%; Optibond FL: 73.3%; p = 0.000). Superficial marginal discoloration increased in both groups (to 53.3% and 36% for Clearfil S3 Bond and Optibond FL, respectively) and was also more pronounced in the Clearfil S3 Bond group (p = 0.007). After 2 years, the simplified one-step self-etch adhesive Clearfil S3 Bond and the three-step etch-and-rinse adhesive Optibond FL were clinically equally successful, even though both adhesives were characterized by progressive degradation in marginal

  7. Serial type-specific human papillomavirus (HPV) load measurement allows differentiation between regressing cervical lesions and serial virion productive transient infections

    International Nuclear Information System (INIS)

    Persistent high-risk human papillomavirus (HPV) infection is strongly associated with the development of high-grade cervical intraepithelial neoplasia (CIN) or cancer. Not all persistent infections lead to cancer. Viral load measured at a single time-point is a poor predictor of the natural history of HPV infections. However the profile of viral load evolution over time could distinguish nonprogressive from progressive (carcinogenic) infections. A retrospective natural history study was set up using a Belgian laboratory database including more than 800,000 liquid cytology specimens. All samples were submitted to qPCR identifying E6/E7 genes of 18 HPV types. Viral load changes over time were assessed by the linear regression slope. Database search identified 261 untreated women with persistent type-specific HPV DNA detected (270 infections) in at least three of the last smears for a average period of 3.2 years. Using the coefficient of determination (R²) infections could be subdivided in a latency group (n = 143; R² < 0.85) and a regressing group (n = 127; R² ≥ 0.85). In (≥3) serial viral load measurements, serial transient infections with latency is characterized by a nonlinear limited difference in decrease or increase of type-specific viral load (R² < 0.85 and slopes between 2 measurements 0.0010 and −0.0010 HPV copies/cell per day) over a longer period of time (1553 days), whereas regression of a clonal cell population is characterized by a linear (R² ≥ 0.85) decrease (−0.0033 HPV copies/cell per day) over a shorter period of time (708 days; P < 0.001). Using serial HPV type-specific viral load measurements we could for the first time identify regressing CIN2 and CIN3 lesions. Evolution of the viral load is an objective measurable indicator of the natural history of HPV infections and could be used for future triage in HPV-based cervical screening programs

  8. 孕期雌激素水平在宫颈癌早期病变中的影响%The Influence of Estrogen Level during Pregnancy in Cervical Cancer Early Lesion

    Institute of Scientific and Technical Information of China (English)

    陆建军

    2015-01-01

    Objective:To analyze the effect of estrogen level during pregnancy in cervical cancer early lesion.Method:220 cases of postpartum outpatients with cervical liquid-based cytology technology (LCT) and 250 cases of cervical cancer screening in our hospital from March 2012 to December 2014 were randomly selected,and then analyzed the pathlogy reports.Result:The positive rate of postpartum outpatients group was 10.0%,the cervical cancer screening group was 5.2%.The difference was statistically significant(P<0.05).Conclusion:Elevated level of estrogen has promoting effect in the diagnosis of cervical cancer early lesion.%目的:分析孕期妇女雌激素变化在宫颈癌早期病变中的影响。方法:随机选择2012年3月-2014年12月笔者所在医院220例产后门诊与同期250例两癌筛查项目中宫颈癌筛查的液基细胞学检查,并分析病理报告。结果:产后门诊组阳性率为10.0%,同期宫颈癌筛查组阳性率为5.2%,差异有统计学意义(P<0.05)。结论:孕期雌激素的剧烈变化对宫颈癌早期病变诊断有促进作用。

  9. HPV16-E2 induces prophase arrest and activates the cellular DNA damage response in vitro and in precursor lesions of cervical carcinoma

    OpenAIRE

    Xue, Yuezhen; Toh, Shen Yon; He, Pingping; Lim, Thimothy; Lim, Diana; Pang, Chai Ling; Abastado, Jean-Pierre; Thierry, Françoise

    2015-01-01

    Cervical intraepithelial neoplasia (CIN) is caused by human papillomavirus (HPV) infection and is the precursor to cervical carcinoma. The completion of the HPV productive life cycle depends on the expression of viral proteins which further determines the severity of the cervical neoplasia. Initiation of the viral productive replication requires expression of the E2 viral protein that cooperates with the E1 viral DNA helicase. A decrease in the viral DNA replication ability and increase in th...

  10. Age-specific prevalence of HPV genotypes in cervical cytology samples with equivocal or low-grade lesions

    Science.gov (United States)

    Brismar-Wendel, S; Froberg, M; Hjerpe, A; Andersson, S; Johansson, B

    2009-01-01

    Background: To define the spectrum of human papillomavirus (HPV) types and establish an age limit for triage HPV testing in atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesion (LSIL). Materials and methods: 343 liquid-based cytological samples from the population-based screening programme with minor abnormalities were subjected to HPV genotyping (Linear Array, Roche, Basel, Switzerland). Results: High-risk human papillomavirus (HR-HPV) was found in 71% of LSIL and 49% of ASCUS cases (P<0.001). High-risk human papillomavirus prevalence was age-dependent in LSIL (P=0.01), with decreasing prevalence until the age of 50 years, followed by a slight increase. Human papillomavirus type 16 was the most common HR-HPV, found in 23% of HPV-positive women. Human papillomavirus type 18 was the sixth most common, found in 9.9% (P<0.001). An age-dependent quadratic trend was observed for multiple infections (P=0.01) with a trough at about 42 years. The most common HR-HPV types to show a coinfection with HPV16 (clade 9) were HPV39 (28%), 45 (38%), and 59 (46%), belonging to HPV18 clade 7. The frequency of low-risk (LR) vs probable HR and HR-HPV also followed an age-dependent quadratic trend. Conclusions: After the age of 25 years, HR-HPV prevalence is similar in LSIL and ASCUS cases, motivating a low age limit for triage HPV testing. Multiple infections and LR/HR-HPV dominance are age-dependent. Genotyping in longitudinal design is needed to elucidate the importance of multiple infections in cancer progression and in cross-protection from vaccination. PMID:19623178

  11. Testing of abrasion materials

    International Nuclear Information System (INIS)

    A method of abrasion testing according to ASTM C 704-76 a is presented for steel fibre concrete mortar, fusion-cast basalt and a surface coating material and results of practical interest are mentioned. Due to the high technical demands on these materials and their specific fields of application, the very first test already supplied interesting findings. From the user's point of view, the method is an interesting alternative to the common test methods, e.g. according to DIN 52 108 (wheel test according to Boehme). In English-speaking countries, testing according to ASTM is often mandatory in the refractory industry in order to assure constant quality of refractory materials after setting. The method is characterized by good comparability and high accuracy of measurement. Only the test piece is exchanged while the test conditions remain constant, so that accurate information on the material studied is obtained. (orig.)

  12. The effect of human papillomavirus DNA testing and cervical cytology for screening of cervical precancerous lesions%人乳头瘤病毒DNA检测和宫颈细胞学检查对宫颈癌前病变筛查的效果

    Institute of Scientific and Technical Information of China (English)

    梁瑜; 彭华丽

    2015-01-01

    Objective To investigate the effect of human papillomavirus (HPV) DNA testing and cervical cytology screening of cervical precancerous lesions. Methods 1100 patients admitted to our hospital who were carried out screening cervical precancerous lesions from January 2013 to June 2014 were selected,all were carried out HPV DNA testing,cervical cytology,colposcopy and cervical biopsy,pathological diagnosis was as the standard,the test results were analyzed. Results Positive rate of HPV DNA testing was 23.00% in 1100 patients,in which,positive rate of cervical cancer was 83.33%,positive rate of cervical intraepithelial neoplasia (CIN) Ⅰ was 44.44%,CIN II testing was 86.67%, CINⅢ positive rate was 94.12%.Cervical cytology results showed that there were 851 cases (77.36%) with no CIN,139 cases (12.64%) were atypical squamous cells,78 cases (7.09%) were low-grade squamous intraepithelial lesion,29 cases (2.64%) of high-grade squamous intraepithelial cells lesions,3 cases (0.27%) of squamous cell carcinoma.The compli-ance rate of colposcopy examination and pathological diagnosis was 62.79% (54/86). Conclusion The suitable cervical lesions screening method for patients can help to improve the detection rate,reduce the incidence rate of cervical cancer.%目的:探讨人乳头瘤病毒(HPV)DNA检测和宫颈细胞学检查对宫颈癌前病变筛查的效果。方法选取2013年1月~2014年6月来本院就诊并进行宫颈癌前病变筛查的1100例患者,均进行HPV DNA检测、宫颈细胞学检查、阴道镜检查与宫颈活检,以病理诊断为标准,对检测结果进行分析。结果1100例患者中,HPV DNA阳性率为23.00豫,其中宫颈癌阳性率为83.33豫,宫颈上皮内瘤变(CIN)Ⅰ阳性率为44.44豫,CINⅡ阳性率为86.67豫,CINⅢ阳性率为94.12豫。宫颈细胞学检查无CIN 851例(77.36豫),非典型鳞状上皮细胞139例(12.64豫),低度鳞状上皮细胞内病变78例(7.09豫),高度鳞状上皮细胞内病变29

  13. Cervical dysplasia

    Science.gov (United States)

    ... by your provider. Make sure to get the HPV vaccine when it is offered to you. This vaccine prevents many cervical cancers. ... Early diagnosis and prompt treatment cures most cases of cervical ... severe cervical dysplasia may change into cervical cancer.

  14. Associação entre o polimorfismo no códon 72 da p53 e as lesões pré-malignas e malignas cervicais Association of codon 72 polymorphism with premalignant and malignant cervical lesions

    Directory of Open Access Journals (Sweden)

    Fernando Anschau

    2005-10-01

    Full Text Available OBJETIVOS: testar a hipótese de que o polimorfismo no códon 72 do gene TP53 é fator de risco para as lesões pré-malignas e malignas cervicais associadas ou não ao papilomavírus humano (HPV. MÉTODOS: foram incluídas amostras de cérvice uterina, para pesquisa de DNA de HPV e do polimorfismo no códon 72 da p53 com o uso da reação em cadeia da polimerase (PCR, de 155 pacientes que se submeteram à biópsia cervical. Foram formados três grupos de acordo com o diagnóstico histológico: lesão escamosa intra-epitelial de baixo grau (LSIL, lesão escamosa intra-epitelial de alto grau (HSIL e carcinoma cervical. Aquelas pacientes sem alterações displásicas, citológicas e histológicas, foram consideradas controles. Para testar a associação entre o polimorfismo no códon 72 do gene TP53 e os grupos, foi utilizado o teste de chi2. Considerou-se como significativo o intervalo de confiança no nível de 95% (alfa=0,05. RESULTADOS: quarenta pacientes tiveram o diagnóstico histológico de carcinoma cervical, 18 tinham HSIL, 24 tinham LSIL e 73 foram consideradas controles. O genótipo Arg/Arg p53 foi encontrado em 60,0% das pacientes com câncer, 50,0% dos casos com HSIL, 45,8% dos casos com LSIL e em 45,2% dos controles. Não houve diferença significativa entre as proporções de cada genótipo da p53 nos diferentes grupos independente da presença do HPV (chi2: 3,7; p=0,716. CONCLUSÕES: nossos dados não suportam a hipótese de que o polimorfismo no códon 72 do gene TP53 é importante no desenvolvimento de lesões cervicais pré-malignas e malignas associadas ou não ao HPV.PURPOSE: to test the hypothesis that gene TP53 codon 72 polymorphism is a risk factor for premalignant and malignant cervical lesions associated or not with human papillomavirus (HPV. METHODS: uterine cervical samples were collected for HPV DNA and TP53 codon 72 polymorphism tests from 155 patients who underwent cervical biopsy. Three groups were formed according

  15. AgNOR polymorphism association with squamous intraepithelial lesions and invasive carcinoma with HPV infection Asociación de los polimorfismos AgNORs con lesiones intraepiteliales escamosas, carcinoma cervical e infección por VPH

    Directory of Open Access Journals (Sweden)

    Luz del Carmen Alarcón-Romero

    2009-04-01

    Full Text Available OBJECTIVE: Evaluate the relationships between AgNORs polymorphisms and squamous intraepithelial lesions (SIL and squamous cell carcinoma (SCC with HPV infection. MATERIALS AND METHODS: A study was carried out on sixty women from the state of Guerrero, Mexico. HPV detection was performed by PCR. AgNORs were identified by argentic impregnation. One hundred cells per slide were counted and classified according to the polymorphism of AgNORs dots; typical (spherical and atypical (large, kidney-shaped and clustered. RESULTS: A total of 100% of the cases were positive for HPV infection. Nine different high-risk HPV genotypes were found, type16 was the most common (48.6%. The AgNORs showed a significant decrease in spherical shape according to neoplastic development. The three atypical shapes showed a significant increase in SIL and SCC (p-trendOBJETIVO: Evaluar la relación entre los polimorfismos de AgNORs con las lesiones intraepiteliales escamosas (LIE y carcinoma de células escamosas (CCE. MATERIAL Y MÉTODOS: Se estudiaron sesenta mujeres del estado de Guerrero, México. La detección del VPH fue por PCR y los AgNORs por impregnación argéntica; se contaron 100 células y se clasificaron por tipo de polimorfismo de AgNORs: típico (esférico y atípicos (largo, forma de riñón o de racimo. RESULTADOS: El 100% de los casos presentaron infección por VPH, se encontraron nueve genotipos diferentes de VPH de alto riesgo, el 16 fue el más común (48.6%. La forma esférica de los polimorfismos de AgNORs mostró una disminución con el desarrollo neoplásico y las atípicas incrementaron progresivamente con SIL y SCC (p-tendencia<0.001. CONCLUSIONES: Los polimorfismos AgNORs se incrementan progresivamente con el grado de lesión histológica, y pueden ser útiles en el pronóstico de progresión del carcinoma cervical.

  16. Study of the relevance of HPV 16 physical states and the degree of Cervical Lesions%人乳头瘤病毒HPV16整合与宫颈病变程度的研究

    Institute of Scientific and Technical Information of China (English)

    朱义保; 谢彤; 杨亮亮; 万磊

    2015-01-01

    目的:研究HPV 16整合与宫颈病变程度的关系,探讨反应宫颈病变的指标。方法收集感染HPV16的标本,慢性宫颈炎/CINⅠ25例(慢性宫颈炎21例,CINⅠ4例),CINⅡ22例,CIN Ⅲ23例,宫颈癌28例,对不同HPV16质粒浓度的E2和E7基因进行定量PCR分析,制作标准曲线,得出游离型和混合型HPV16 E2/E7的临界值,并对样本进行扩增,根据临界值,分析HPV16整合在不同宫颈病变的分布情况。结果标准曲线制作良好,相关系数均在0.97以上;不同HPV16质粒浓度的E2/E7比值显示,0.77为游离型和混合型HPV16的临界值;根据该临界值,发现慢性宫颈炎/CINⅠ、CINⅡ、CINⅢ、宫颈癌的HPV16的整合率分别为4.00%、9.09%、13.04%、10.71%,统计显示HPV16整合率在不同宫颈病变中没有统计学差异(P>0.05),因混合型HPV16也存在病毒整合,把整合型和混合型HPV16合并,得出HPV16总整合率在慢性宫颈炎/CINⅠ、CINⅡ、CINⅢ、宫颈癌分别为48.00%、59.09%、65.22%、75.00%,分析显示HPV16总整合率在各宫颈病变程度间亦不显著(P>0.05),HPV16总整合率在宫颈病变的分布亦无差异。结论 HPV16整合与宫颈病变程度的关系不明显,病毒整合是宫颈病变的早期事件,不能反应宫颈病变程度的变化。%Objective To study the connection of HPV 16 integration and the degree of Cervical Lesions, and investigate the in-dex of Cervical Lesions. Methods HPV16 infected samples were collected, including 21 chronic cervicitis, 4 CINⅠ, 22 CINⅡ, 23 CINⅢand 28 cervical carcinoma. Standard curves were made by amplifing E2 and E7 gene of HPV16 plasmid with different con-certration by Quantitative PCR, and the cut-off value was obtained. Then samples were detected and the distribution of HPV 16 in-tegration was analyzed in different Cervical Lesions according the cut-off value. Results The standard curves were well made, corre-lation coefficients

  17. 宫颈薄层液基细胞学检查联合高危型HPV检测在宫颈病变筛查中的临床应用%CLINICAL APPLICATION OF CERVICAL THIN PREP CYTOLOGIC-TEST AND HIGH-RISK HPV TYPE TESTING IN SCREENING OF CERVICAL LESIONS

    Institute of Scientific and Technical Information of China (English)

    朱华洁

    2012-01-01

    目的 研究宫颈薄层液基细胞学检查(thin prep cytologic test,TCT)联合高危型人乳头瘤病毒(human papilloma virus,HPV)检测在子宫颈病变筛查中的诊断价值.方法对2010年1-12月行宫颈病变筛查的患者680例,进行TCT和高危型HPV检测,同时行阴道镜下组织活检.结果 680例患者中宫颈TCT检查结果异常180例,对宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)诊断的敏感性为85.57%,特异性为97.12%,漏诊率为4.12%.TCT与HPV联合检查,诊断敏感性为89.69%,特异性为85.80%,漏诊率1.62%.HPV感染率为26.91%,随着细胞学和组织学诊断级别的升高,HPV感染率不断上升.结论 TCT与高危型HPV联合检测是筛查宫颈癌及癌前病变的有效方法,可防止漏诊,有利于提高宫颈上皮内瘤变的诊断率.%Objective To explore the diagnostic value of cervical thin prep cytologic test ( TCT ) combined with high - risk human papilloma virus ( HPV ) detection in the screening of cervical lesions. Methods A total of 680 patients for cervical lesions screeing underwent TCT and high - risk HPV type detection in gynecology outpatient from January 2010 to December 2010, meanwhile, biopsy was performed under colposcopy. Results Among 680 cases,the result of cervical TCT was abnormal in 180 cases. The sensitivity, specificity and the rate of missed diagnosis of TCT for the diagnosis of cervical intraepithelial neoplasia ( CIN ) was 85.57% , 97. 12% and 4. 12% , respectively, while thoses of combination of TCT and HPV was 89. 69% ,85. 80% and 1. 62%. The infection rate of HPV was 26. 91%. With the increase of cytological and histological grading, the infection rate of HPV increased. Conclusion TCT combined with high risk HPV detection is an effective method in screening cervical cancer and precancerous lesions. It helps to prevent missed diagnosis and improve the diagnosis rate of CIN.

  18. Invasive Stratified Mucin-producing Carcinoma and Stratified Mucin-producing Intraepithelial Lesion (SMILE): 15 Cases Presenting a Spectrum of Cervical Neoplasia With Description of a Distinctive Variant of Invasive Adenocarcinoma.

    Science.gov (United States)

    Lastra, Ricardo R; Park, Kay J; Schoolmeester, J Kenneth

    2016-02-01

    Stratified mucin-producing intraepithelial lesion (SMILE) is a cervical intraepithelial lesion, distinct from conventional squamous or glandular counterparts, believed to arise from embryonic cells at the transformation zone by transdifferentiation during high-risk HPV-associated carcinogenesis. It is characterized by stratified, immature epithelial cells displaying varying quantities of intracytoplasmic mucin throughout the majority of the lesional epithelium. We identified a distinct form of invasive cervical carcinoma with morphologic features identical to those in SMILE, which we have termed "invasive stratified mucin-producing carcinoma." Fifteen cases from 15 patients (mean 36 y; range, 22 to 64 y) were retrieved from the pathology archives of multiple institutions with a diagnosis of either SMILE or invasive cervical carcinoma with a description or comment about the invasive tumor's resemblance to SMILE. Seven cases had solely intraepithelial disease with a component of SMILE (mean 29 y; range, 22 to 40 y). The 8 other cases had invasive stratified mucin-producing carcinoma (mean 44; range, 34 to 64 y) in which SMILE was identified in 7. All cases of invasive stratified mucin-producing carcinoma demonstrated stratified, immature nuclei with intracytoplasmic mucin, which morphologically varied between cases from "mucin-rich" to "mucin-poor" in a similar manner to SMILE. All cases had mitotic figures and apoptotic debris, and an intralesional neutrophilic infiltrate was seen in the majority of cases. In cases of invasive carcinoma, the depth of invasion ranged from growth patterns. Given that SMILE is well rooted as a distinct intraepithelial lesion, we propose "invasive stratified mucin-producing carcinoma" to describe its corresponding form of invasive carcinoma. PMID:26523540

  19. Complete Genome Sequences of Eight Human Papillomavirus Type 16 Asian American and European Variant Isolates from Cervical Biopsies and Lesions in Indian Women

    OpenAIRE

    Mandal, Paramita; Bhattacharjee, Bornali; Sen, Shrinka; Bhattacharya, Amrapali; Roy Chowdhury, Rahul; Mondal, Nidhu Ranjan; Sengupta, Sharmila

    2016-01-01

    Human papillomavirus type 16 (HPV16), a member of the Papillomaviridae family, is the primary etiological agent of cervical cancer. Here, we report the complete genome sequences of four HPV16 Asian American variants and four European variants, isolated from cervical biopsies and scrapings in India.

  20. Complete Genome Sequences of Eight Human Papillomavirus Type 16 Asian American and European Variant Isolates from Cervical Biopsies and Lesions in Indian Women.

    Science.gov (United States)

    Mandal, Paramita; Bhattacharjee, Bornali; Sen, Shrinka; Bhattacharya, Amrapali; Roy Chowdhury, Rahul; Mondal, Nidhu Ranjan; Sengupta, Sharmila

    2016-01-01

    Human papillomavirus type 16 (HPV16), a member of the Papillomaviridae family, is the primary etiological agent of cervical cancer. Here, we report the complete genome sequences of four HPV16 Asian American variants and four European variants, isolated from cervical biopsies and scrapings in India. PMID:27198009

  1. Abrasion-resistant antireflective coating for polycarbonate

    Science.gov (United States)

    Wydeven, T. J.

    1978-01-01

    Following plasma-polymerization technique, treatment in oxygen glow discharge further enhances abrasion resistance and transmission. Improvement in abrasion resistance was shown by measuring percentage of haze resulting from abrasion. Coating samples were analyzed for abrasion using standard fresh rubber eraser. Other tests included spectra measurements and elemental analysis with spectrometers and spectrophotometers.

  2. Clinical report in treating cervical disc herniation by nucleoplasty of percutaneous radiofrequency abrasion%多靶点射频消融术治疗颈椎间盘突出症临床疗效分析

    Institute of Scientific and Technical Information of China (English)

    卫秀洋; 陈勇忠; 周清碧; 王金星; 陈庆泉

    2013-01-01

    目的 探讨射频消融髓核成形术治疗颈椎间盘突出症的临床疗效.方法 回顾2009 年10月~2010年10月福州总医院476医院应用经皮穿刺多靶点射频消融髓核成形术治疗颈椎间盘突出症168 例.按Macnab 疗效评定标准和视觉模拟评分法(VAS),对比患者手术前后及随访时进行疗效评定.结果 按Macnab 疗效评分标准,术后即刻优76例,良64例,可22例,差6例,优良率为83.33%.本组术前VAS评分为(6.76±0.52)分,术后即刻为(2.15±0.58)分,术后3个月为(2.68±0.56)分,术后1年为(2.95±0.63)分,术后即刻、术后3个月、术后1年评分与术前比较差异有高度统计学意义(P < 0.01).结论 射频消融髓核成形术治疗颈椎病具有操作简单、安全微创、并发症少、起效快及近、中期疗效满意等特点,是治疗轻度颈椎间盘突出症较好的方法.%Objective To observe therapeutic effect of radiofrequency ablation nucleoplasty on cervical disc herniation. Methods From October 2009 to October 2010, 168 patient with cervical disc herniation were analyzed NO.476 Hospital of PLA, who were treated by percutaneous multi-target radiofrequency ablation nucleoplasty treatment. Therapeutic effects were evaluated before and after surgery, 3 month and 12 month by using the average scores of VAS and Mac-nab evaluation standard. Results All cases were followed-up from immediate postoperative to 12 months after operation. According to Macnab efficacy score, the immediate postoperative period were excellent in 76 cases, good in 64 cases, maybe 22 cases and poor in 6 cases, the total good rate of 83.33%. The preoperative VAS score was (6.76±0.52) scores, immediately after was (2.15 ±0.58) scores, 3 months after surgery was (2.68 ±0.56) scores, after an annual was (2.95±0.63) scores. There were significant difference between preoperative surgery and intraoperative immediately after surgery, 3 months after surgery, 1 year after surgery (P < 0

  3. Sandstone Turning by Abrasive Waterjet

    Czech Academy of Sciences Publication Activity Database

    Hlaváček, Petr; Cárach, J.; Hloch, Sergej; Vasilko, K.; Klichová, Dagmar; Klich, Jiří; Lehocká, D.

    2015-01-01

    Roč. 48, č. 6 (2015), s. 2489-2493. ISSN 0723-2632 R&D Projects: GA MŠk ED2.1.00/03.0082; GA MŠk(CZ) LO1406 Institutional support: RVO:68145535 Keywords : turning away from the jet * conventional turning towards the jet * sandstone * abrasive water jet Subject RIV: JQ - Machines ; Tools Impact factor: 2.420, year: 2014 http://www.springerprofessional.de/sandstone-turning-by-abrasive-waterjet/6038028.html

  4. Clinical Value of Liquid-based Cytology in the Diagnosis of Cervical Lesions%液基细胞学检查在诊断宫颈病变中的临床价值

    Institute of Scientific and Technical Information of China (English)

    姜丽红; 杨滨

    2011-01-01

    [目的]探讨宫颈液基细胞学检查(TCT)对宫颈病变的诊断价值及意义.[方法]回顾性分析中国医科大学附属盛京医院门诊57 784例TCT筛查结果.细胞学诊断采用TBS(2001)分级报告系统,阳性诊断包括意义不明确的不典型鳞状细胞(ASC-US)及以上病变,其中阳性者554例行阴道镜下宫颈活组织检查,其中317例同时又进行了宫颈高危型人乳头瘤病毒DNA(HPV-DNA)检测,对三者进行了对比分析.另外对经宫颈活检证实为宫颈癌并同时有TCT检测结果的103例患者结果也进行了对比分析.[结果]①TCT检查阳性结果与宫颈活检诊断符合率:鳞状细胞癌(SCC)3例及腺癌4例均符合组织病理学诊断;高级别鳞状上皮内病变(HSIL)符合率为86.67%(91/105),低级别鳞状上皮内瘤变(LSIL)符合率为33.93% (38/112);②经宫颈活检证实为原位癌和SCC患者TCT与宫颈活检诊断的符合率为28.57%(26/91),假阴性率38.46%(35/91),经宫颈活检证实为腺癌患者TCT与宫颈活检诊断的符合率为50.00%(6/12),假阴性率41.67%(5/12);③TCT提示HPV感染与宫颈HPV-DNA检测的符合率为79.00%(173/219);④宫颈高危型HPV-DNA 阳性检出率与组织病理学分级正相关.[结论]TCT用于宫颈病变筛查,能够及时发现大量的宫颈病变,TCT结果为HSIL及宫颈癌的患者与宫颈活检诊断的符合率较高.TCT提示HPV感染有较高的准确性,但TCT对宫颈癌筛查有较高的假阴性率.对于TCT检查阴性、而临床高度可疑恶性病变、年龄较大的患者应予以重视,进一步做阴道镜检查及高危型HPV-DNA检测和宫颈活组织检查,尤其是宫颈管诊刮,以降低宫颈癌的漏诊率.高危型HPV-DNA检测可以作为TCT诊断的客观控制指标,还可作为ASC-US及LSIL患者分流无病与患病人群的检查.%[Objective] To explore the value of liquid-based cervical cytology(TCT) for the diagnosis of cervical lesions and its significance. [Methods] The TCT

  5. 液基细胞学及HPV分型检测在宫颈病变筛查中的应用%Thinprep Cytology Test and HPV Genotyping in Screening of Cervical Lesions

    Institute of Scientific and Technical Information of China (English)

    焦凤娟; 韩洁

    2013-01-01

    Objective: To investigate the clinical significance of thinprep cytology test (TCT) and HPV genotyping in cervical le-sions. Methods: TCT and HPV genotyping were done for 390 cases of cervical lesions, and did the biopsy for who was ≥ASCUS. Results: In the 390 cases, the positive rates of TCT and HPV were 26.41% and 28.72%; the rate of high-risk type of HPV in 103 cas-es of TCT-positive patients was 63.11%, and the biopsy showed that there were inflammation 46 cases, CIN I 24 cases, CIN II 12 cases, CIN III 18 cases and cervical cancer 3 cases. Conclusion: TCT and HPV genotyping can improve the detection rate of cervical cancer and precancerous lesions, it has important significance in early diagnosis and prevention for cervical cancer.%  目的:探讨液基细胞学(TCT)联合HPV 分型检测在宫颈病变筛查中的临床意义.方法:对390例宫颈病变患者行TCT 检查和 HPV 检测,对≥ASCUS 患者行组织活检.结果:390例患者中 TCT 和 HPV 阳性率分别为26.41%、28.72%;103例TCT阳性患者中高危型HPV阳性率为63.11%,组织活检结果为炎症46例、CIN I 24例、CIN II 12例、CIN III 18例和宫颈癌3例.结论:TCT联合HPV检测可提高对宫颈癌及癌前病变的检出率,对宫颈癌的早期诊断和防治有重要临床意义.

  6. Avaliação da conduta conservadora na lesão intraepitelial cervical de alto grau Evaluación de la conducta conservadora en la lesión intraepitelial cervical de alto grado Evaluation of conservative management of high-grade cervical squamous intraepithelial lesion

    Directory of Open Access Journals (Sweden)

    Nelson Shozo Uchimura

    2012-06-01

    transversal y retrospectivo realizado con 509 mujeres (15-76 años atendidas en el período de 1996 a 2006, con colpocitología oncótica alterada, en un servicio público de referencia en Maringá, Sur de Brasil. Los datos fueron colectados de los prontuarios médicos y se estudiaron las variables diagnóstico definitivo, tipos de tratamiento, ocurrencia de la lesión y reincidencias y se analizaron por medio de pruebas de asociación de chi-cuadrado de Pearson y exacto de Fisher. RESULTADOS: La lesión intraepitelial cervical de alto grado ocurrió en 168 casos; de estos, 31 mujeres se sometieron a la amputación cónica, 104 a cirugías de alta frecuencia, nueve a histerectomías y 24 recibieron conducta conservadora. Entre las mujeres con lesión de alto grado y tratadas de forma conservadora, ocho (33,3% reincidieron, mientras que de las sometidas a la conducta no conservadora, diez (6,9% reincidieron, siendo esta diferencia estadísticamente significativa (p=0,0009, RP=4,8 (IC95% 2,11;10,93. En aquellas que hicieron seguimiento clínico-citológico, tres (30,0% y, entre las cauterizadas, cinco (35,7% reincidieron en el plazo de tres años, sin diferencia significativa (p=0,5611. La reincidencia por debajo y por encima de los 30 años ocurrió, respectivamente, en siete (13,8% y 11 (12,2% mujeres (p=0,9955. CONCLUSIONES: La edad de la mujer no influencia el pronóstico de la reincidencia. El tratamiento conservador debe ser indicado como conducta de excepción, dada la alta tasa de reincidencia, y el seguimiento debe ser riguroso, con acompañamiento citológico y colposcópico por inclusive tres años, período en el que ocurre la mayoría de las reincidencias.OBJECTIVE: To assess the association between conservative management of high-grade cervical squamous intraepithelial lesions and recurrence rates and age groups. METHODS: Cross-sectional, retrospective, analytical observational study of 509 women (aged 15 to 76 with abnormal Pap smears attending a public reference

  7. CD28-, CD45RAnull/dim and natural killer-like CD8+ T cells are increased in peripheral blood of women with low-grade cervical lesions

    OpenAIRE

    Pita-Lopez, Maria Luisa; Ortiz-Lazareno, Pablo Cesar; Navarro-Meza, Monica; Santoyo-Telles, Felipe; Peralta-Zaragoza, Oscar

    2014-01-01

    Background In response to antigen naive CD8+, T cells differentiate into effector cells, which express Natural killer (NK) receptors, lose CD28 expression, and die by apoptosis. However, in smaller quantities, the cells are retained for subsequent exposure to the same antigen. Knowledge is limited regarding whether the percentages of CD28-, Effector memory (EMRAnull/dim), and the CD16+/CD56 + CD8+ T cells of women with low-grade cervical lesions are altered at a systemic level. Methods We enr...

  8. Augmented serum level of major histocompatibility complex class I-related chain A (MICA) protein and reduced NKG2D expression on NK and T cells in patients with cervical cancer and precursor lesions

    International Nuclear Information System (INIS)

    Cervical cancer is the second most common cancer in women worldwide. NK and cytotoxic T cells play an important role in the elimination of virus-infected and tumor cells through NKG2D activating receptors, which can promote the lysis of target cells by binding to the major histocompatibility complex class I-related chain A (MICA) proteins. Increased serum levels of MICA have been found in patients with epithelial tumors. The aim of this study was to compare the levels of soluble MICA (sMICA) and NKG2D-expressing NK and T cells in blood samples from patients with cervical cancer or precursor lesions with those from healthy donors. Peripheral blood with or without heparin was collected to obtain mononuclear cells or sera, respectively. Serum sMICA levels were measured by ELISA and NKG2D-expressing immune cells were analyzed by flow cytometry. Also, a correlation analysis was performed to associate sMICA levels with either NKG2D expression or with the stage of the lesion. Significant amounts of sMICA were detected in sera from nearly all patients. We found a decrease in the number of NKG2D-expressing NK and T cells in both cervical cancer and lesion groups when compared to healthy donors. Pearson analysis showed a negative correlation between sMICA and NKG2D-expressing T cells; however, we did not find a significant correlation when the analysis was applied to sMICA and NKG2D expression on NK cells. Our results show for the first time that high sMICA levels are found in sera from patients with both cervical cancer and precursor lesions when compared with healthy donors. We also observed a diminution in the number of NKG2D-expressing NK and T cells in the patient samples; however, a significant negative correlation between sMICA and NKG2D expression was only seen in T cells

  9. CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women

    International Nuclear Information System (INIS)

    Cervical cancer, caused by specific oncogenic types of human papillomavirus (HPV), is the second most common cancer in women worldwide. A large number of young sexually active women get infected by HPV but only a small fraction of them have persistent infection and develop cervical cancer pointing to co- factors including host genetics that might play a role in outcome of the HPV infection. This study investigated the role of CCR2-V64I polymorphism in cervical cancer, pre-cancers and HPV infection in South African women resident in Western Cape. CCR2-V64I polymorphism has been previously reported to influence the progression to cervical cancer in some populations and has also been associated with decreased progression from HIV infection to AIDS. Genotyping for CCR2-V64I was done by PCR-SSP in a case-control study of 446 women (106 black African and 340 mixed-ancestry) with histologically confirmed invasive cervical cancer and 1432 controls (322 black African and 1110 mixed-ancestry) group-matched (1:3) by age, ethnicity and domicile status. In the control women HPV was detected using the Digene Hybrid Capture II test and cervical disease was detected by cervical cytology. The CCR2-64I variant was significantly associated with cervical cancer when cases were compared to the control group (P = 0.001). Further analysis comparing selected groups within the controls showed that individuals with abnormal cytology and high grade squamous intraepitleial neoplasia (HSIL) did not have this association when compared to women with normal cytology. HPV infection also showed no association with CCR2-64I variant. Comparing SIL positive controls with the cases showed a significant association of CCR2-64I variant (P = 0.001) with cervical cancer. This is the first study of the role of CCR2-V64I polymorphism in cervical cancer in an African population. Our results show that CCR2-64I variant is associated with the risk of cervical cancer but does not affect the susceptibility to HPV

  10. Conduit Coating Abrasion Testing

    Science.gov (United States)

    Sullivan, Mary K.

    2013-01-01

    During my summer internship at NASA I have been working alongside the team members of the RESTORE project. Engineers working on the RESTORE project are creating ·a device that can go into space and service satellites that no longer work due to gas shortage or other technical difficulties. In order to complete the task of refueling the satellite a hose needs to be used and covered with a material that can withstand effects of space. The conduit coating abrasion test will help the researchers figure out what type of thermal coating to use on the hose that will be refueling the satellites. The objective of the project is to determine whether or not the conduit coating will withstand the effects of space. For the RESTORE project I will help with various aspects of the testing that needed to be done in order to determine which type of conduit should be used for refueling the satellite. During my time on the project I will be assisting with wiring a relay board that connected to the test set up by soldering, configuring wires and testing for continuity. Prior to the testing I will work on creating the testing site and help write the procedure for the test. The testing will take place over a span of two weeks and lead to an informative conclusion. Working alongside various RESTORE team members I will assist with the project's documentation and records. All in all, throughout my internship at NASA I hope to learn a number of valuable skills and be a part of a hard working team of engineers.

  11. Triage of women with minor cervical lesions: data suggesting a "test and treat" approach for HPV E6/E7 mRNA testing.

    Directory of Open Access Journals (Sweden)

    Sveinung Wergeland Sørbye

    Full Text Available BACKGROUND: Human papillomavirus (HPV testing is included in the cervical cancer screening program in the triage of women with equivocal (ASC-US or low-grade (LSIL cytological lesions. These women have an increased risk for developing high grade dysplasia and cancer (CIN2+ compared to women with normal cytology. However, in order to avoid unnecessary follow-up, as well as overtreatment, a high positive predictive value (PPV of the triage test is important. METHODOLOGY/PRINCIPAL FINDINGS: The HPV test PreTect HPV-Proofer, detecting E6/E7 mRNA from the HPV types 16, 18, 31, 33 and 45, is used as triage test together with repeat cytology. PPV data for HPV E6/E7 mRNA testing during the period from January 2006 up to June 2009 are reported. In total, 406 of 2099 women (19.3% had a positive HPV test result. Of the women with a positive test result and with a histological diagnosis (n = 347, 243 women had histological high-grade dysplasia or cancer (CIN2+, giving a PPV of 70.0% (95% confidence interval [CI], 65.2%-74.8%. For HPV 16 or HPV 33 positive women above 40 years of age, the PPV was 83.7% (95% CI, 73.3%-94.0% and 84.6% (95% CI, 65.0%-100.0% respectively. The PPV of test positive women with HSIL cytology was 94.2% (95% CI, 88.7%-99.7%. CONCLUSIONS: When the result in triage is HPV mRNA positive, our data suggest direct treatment for women above 40 years of age or for women with a concurrent cytological HSIL diagnosis, contributing to better clinical safety for these women. In addition, by decreasing the time to treatment, thereby reducing the number of recalls, the patient management algorithm will be considerably improved, in turn reducing follow-up costs as well as unnecessary psychological stress among patients.

  12. HC2-HPV-DNA 检测在宫颈癌病变中的临床分析%Clinical Analysis of HC2-HPV-DNA Testing in Cervical Lesions

    Institute of Scientific and Technical Information of China (English)

    季冰; 何浪驰; 郭芝亮; 施全; 黄子健; 黄峥; 黄柳

    2015-01-01

    Objective To observe hybrid capture 2 high-risk human papilloma virus DNA(HC2-HPV-DNA) in cervical lesion screening and accuracy .Methods 110 cases of patients with suspected symptoms of cervical lesion were selected as the research object,and respectively received liquid-based thinlayer cytology test(LCT)inspection,HC2-HPV-DNA testing and cervi-cal tissues pathology biopsy .Positive rate,sensitivity,specificity,and predictive value of LCT,HC2-HPV-DNA testing and the joint inspection were analyzed.Results HC2-HPV-DNA positive rate increased with the increase of cervical lesion severity ,there had statistical difference(P <0.05),sensitivity,specificity,and positive predictive value of HC2-HPV-DNA with LCT joint detection were 78.1%,40% and 95.3%,respectively,the sensitivity significantly increased than single detection (P <0.05).Conclusion HC2-HPV-DNA is a good reference indicator in cervical lesion screening ,the accuracy increases with the increase of the degree of pathological changes,HC2-HPV-DNA and LCT joint detection can improve the accuracy of the diagnosis of cervical cancer and precancerous lesions.%目的:观察分析采用2代杂交捕获法检测高危人乳头状瘤病毒 DNA(HC2-HPV-DNA)对宫颈癌病变筛查中的应用及准确性。方法选取110例疑似宫颈癌患者为研究对象,分别进行宫颈液基薄层细胞学(LCT)检查、HC2-HPV-DNA 检测及宫颈组织病理活检,观察分析 LCT 检查、HC2-HPV-DNA 检测和二者联合检查阳性率、敏感性、特异性及预测值情况。结果随着宫颈病变严重程度的增加,HC2-HPV-DNA 的阳性率升高,差异有统计学义意(P <0.05), HC2-HPV-DNA 与 LCT 联合检测敏感性、特异性、阳性预测值分别为78.1%、40.0%、95.3%,敏感性较单独检测显著提高(P <0.05)。结论HC2-HPV-DNA 是宫颈癌病变筛选的良好参照指标,随病变程度的增加,

  13. Abrasives and possibilities of increase in efficiency of abrasive waterjets

    Czech Academy of Sciences Publication Activity Database

    Martinec, Petr; Sitek, Libor

    Ostrava: Ústav geoniky AV ČR, v.v.i, 2015 - (Sitek, L.; Klichová, D.), s. 157-163 ISBN 978-80-86407-56-2. [Vodní paprsek 2015 - výzkum, vývoj, aplikace. Velké Losiny (CZ), 06.10.2015-08.10.2015] R&D Projects: GA MŠk ED2.1.00/03.0082; GA MŠk(CZ) LO1406 Institutional support: RVO:68145535 Keywords : abrasive waterjets * abrasives * garnet * zirconia Subject RIV: JQ - Machines ; Tools

  14. Combined effect of end-rounded versus tapered bristles and a dentifrice on plaque removal and gingival abrasion.

    Science.gov (United States)

    Caporossi, Leonardo Stephan; Dutra, Danilo Antonio Milbradt; Martins, Maritieli Righi; Prochnow, Emilia Pithan; Moreira, Carlos Heitor Cunha; Kantorski, Karla Zanini

    2016-01-01

    Two previous clinical studies evaluated the effect of end-rounded versus tapered bristles of soft manual brushes on the removal of plaque and gingival abrasion. However, the combined effect of an abrasive dentifrice on these outcomes has yet to be understood. The purpose of the present study was to compare the incidence of gingival abrasion and the degree of plaque removal obtained after the use of toothbrushes with tapered or end-rounded bristles in the presence or absence of an abrasive dentifrice. The study involved a randomized, single-blind, crossover model (n = 39) with a split-mouth design. Subjects were instructed to refrain from performing oral hygiene procedures for 72 hours. Quadrants were randomized and subjects brushed with both types of toothbrushes using a dentifrice (relative dentin abrasion = ± 160). Plaque and gingival abrasion were assessed before and after brushing. After 7 days, the experiment was repeated without the dentifrice. The average reduction in plaque scores and the average increase in the number of abrasion sites were assessed by repeated-measures ANOVA and Bonferroni's post-hoc tests. End-rounded bristles removed significantly more plaque than tapered bristles, regardless of the use of a dentifrice. The dentifrice did not improve plaque removal. In the marginal area (cervical free gingiva), no difference in the incidence of gingival abrasion was detected between toothbrush types when used with a dentifrice (p ≥ 0.05). However, the dentifrice increased the incidence of abrasion (p causing a higher incidence of gingival abrasion when compared with tapered bristles. An abrasive dentifrice can increase the incidence of abrasion, and should be used with caution by individuals who are at risk of developing gingival recession. PMID:26981758

  15. Conversion of a one-step self-etch adhesive into a two-step self-etch adhesive: six-months clinical results in non-carious cervical lesions

    Directory of Open Access Journals (Sweden)

    Neimar Sartori

    2013-04-01

    Full Text Available PURPOSE: The purpose of this randomized controlled clinical trial was to evaluate the clinical performance of a one-step self-etch adhesive system in non-carious cervical lesions with and without the application of an additional hydrophobic resin coat. MATERIALS AND METHODS: Sixty-four non-carious cervical lesions were selected and randomly assigned to one of the two bonding technique: 1 a one-step self-etch adhesive (Adper Easy Bond, 3M ESPE was applied following manufacturer´s instructions; 2 a hydrophobic resin coat (Scotchbond Multipurpose Bonding Agent, 3M ESPE was applied over the uncured Adper Easy Bond adhesive. All lessons were restored using a microhybrid composite resin (Filtek Z250, 3M ESPE. Clinical effectiveness was recorded at baseline and after 6-months of clinical service. RESULTS: Two restorations of each group debonded after a 6-months period. The overall clinical success was 93.8%, and no statistical significant differences could be detected for all evaluated criteria within this period. CONCLUSION: The applications of a hydrophobic resin coat over Easy Bond did not increase bonding effectiveness over a 6-months period.

  16. Application of thinprep cytology test and cervical smear combined with colposcope in screening of cervical lesions%液基细胞学、宫颈刮片联合阴道镜在宫颈病变筛查中的应用

    Institute of Scientific and Technical Information of China (English)

    江明珠

    2015-01-01

    目的 探讨液基细胞学(TCT)、宫颈刮片联合阴道镜在宫颈病变筛查中的应用价值. 方法 选取2014年1月~2015年4月来我所妇科门诊行TCT筛查的1726例妇女(门诊组)和在乡镇行宫颈刮片细胞学筛查的26 021例妇女(乡镇组)作为研究对象,两组均行TBS分级诊断,将细胞学阳性者进一步行阴道镜及镜下活组织病理学检查,分析两组不同取材方法的细胞学筛查结果,并观察细胞学阳性者的阴道镜和病理组织学检查结果. 结果 两组细胞学检出阳性率差异有统计学意义(X2=86.56,P0.05). 以病理组织学诊断为金标准,宫颈癌前病变和宫颈癌(CIN+SCC)两者合计,阴道镜诊断符合率为90.14%(128/142), 细胞学诊断符合率为70.73%(87/123). 结论 TCT筛查法优于传统刮片细胞学筛查法,联合应用阴道镜及镜下活检组织病理学检查,可明显提高宫颈癌前病变及宫颈癌的检出.%Objective To discuss the application value of thinprep cytology test(TCT) and cervical smear combined with colposcope in screening of cervical lesions. Methods 1726 cases of female patients (outpatient group) visited outpatient clinic in our hospital from January 2014 to April 2015 and 26 021 cases of rural women (rural group) receiving cervical cancer screening were selected as research object.Two groups were diagnosed by TBS classification,and those with pos-itive cytologic results were further examined by colposcope and histopathological examination.The cytologic screening results in two groups were analyzed by different methods, the colposcope and histopathologic results of patients with positive cytologic results were observed. Results There was significant difference in positive rate of cytologic results be-tween two groups (X2=86.56,P0.05).The gold standard was diagnosed by histopathology.The total of cervical precancerous lesions and cervical cancer (CIN+SCC),colposcope diagnosis coincidence rate was 90.14%(128/142),and cytology

  17. Diagnostic value of cervical cytological examination, HPV-DNA test combined with colposcopy examination in cervical lesions diagnosis%宫颈细胞学检查、HPV-DNA检测配合阴道镜检查对子宫颈病变的诊断价值

    Institute of Scientific and Technical Information of China (English)

    李玉欢

    2013-01-01

    目的 分析与探讨宫颈细胞学检查、HPV-DNA(人乳头瘤病毒基因检测)检测配合阴道镜检查对于子宫颈病变的诊断价值.方法 选取本院2010年8月至2012年8月期间收治的接受子宫颈病变筛查的妇女共1020例,对其实施宫颈细胞学检查和HPV-DNA配合阴道镜检查,检查结果与组织学金标准进行比对,以对比两种方法的准确性与诊断价值.结果 采取HPV-DNA配合阴道镜检查为异常结果的检出率较宫颈细胞学检查更高,差异具有统计学意义(P<0.05),前者检出异常共64例,后者检出异常共34例.结论 宫颈细胞学检查、HPV-DNA检测以及阴道镜检查对于子宫颈病变均有一定的诊断价值,而采用HPV-DNA检测配合阴道镜检查能够帮助医生较早地发现患者的宫颈癌前病变,为患者的治疗方案的选择提供科学依据.%Objective To analyze and discuss the diagnostic value of cervical cytological examination,HPV-DNA test combined with colposcopy examination in diagnosis of cervical lesions.Methods From August 2010 to August 2012 in our hospital a total of 1020 cases of women who underwent cervical diseases screening,were implemented with cervical cytological examination and HPV-DNA combined with colposcopy examination,the correlated pathological results were compared with the gold standard in accuracy and diagnostic value of two methods.Results The HPV-DNA abnormal results detection rate was higher than that of cervical cytological examination combined with colposcopy examination,with statistically significant difference,former found 64 abnormal cases,the latter examination found 34 cases of abnormal.Conclusion Cervical cytological examination,HPV-DNA testing combined with colposcopy examination for cervical lesions has certain diagnostic value,and the combined use of HPV-DNA testing and colposcopy examination could help doctors find early precancerous lesion of cervical cancer,and provide scientific basis for the

  18. Checking Out Cuts, Scratches, and Abrasions

    Science.gov (United States)

    ... Skating Crushes What's a Booger? Checking Out Cuts, Scratches, and Abrasions KidsHealth > For Kids > Checking Out Cuts, ... weren't wearing kneepads. How Do Cuts and Scratches Heal? After getting a cut, scratch, or abrasion, ...

  19. The research progress of vagina lactobacillus is associated with cervical lesions%阴道乳杆菌与宫颈病变相关的研究进展

    Institute of Scientific and Technical Information of China (English)

    辛秀团

    2015-01-01

    The cervical lesion is one of the major diseases threatening the health of women, in the context of its incidence, second only to breast cancer in female malignant tumor in the whole world, in some countries even than the breast cancer incidence of a disease. Mainly concentrated in cervical lesions in patients with age between 30 to 45 years old, and as the patient age incidence is obviously rising trend. At home and abroad at present, many scholars believe that the cervical lesions have direct links to the fall in the number of lactobacillus in the vagina, aimed at this situation, this study from the antitumor mechanism and original microbial antagonism disease-resistant two aspects of lactobacillus in the vagina and cervix lesion of correlation analysis, the peers to play the role of reference and reference.%宫颈病变是威胁妇女健康的主要疾病之一,就其发病率来看,在全球女性恶性肿瘤中仅次于乳腺癌,在部分国家中发病率甚至超过了乳腺癌。宫颈病变患者年龄主要集中在30-45岁之间,而且随着患者年龄的增长发病率呈明显上升趋势。目前,国内外诸多学者认为宫颈病变与阴道乳杆菌数量下降有着直接的联系,针对这一现状,本研究从抗肿瘤机制以及拮抗病原微生物两个方面对阴道乳杆菌与宫颈病变的相关性进行分析,希望能够对广大同行起到借鉴与参考的作用。

  20. PROGRESS IN THERMO-ABRASIVE BLASTING SYSTEMS

    OpenAIRE

    I.A. Gorlach

    2012-01-01

    ENGLISH ABSTRACT: Quality of surface preparation of components and structures for further painting and/or coating is important in many fields of engineering. One of the most widely used methods of surface preparation is abrasive blasting. In the last few years, a new method for surface preparation has evolved, namely thermo-abrasive blasting. This technique utilises a high enthalpy thermal jet, generated by the thermo-abrasive blasting gun, to propel abrasive particles. Thermo-abrasi...

  1. Lung scintigraphy evaluation in workers exposed to abrasive dusts

    International Nuclear Information System (INIS)

    The production process of abrasives use aluminium, or silicon carbide a synthetic material with a hardness only slightly less than that of a diamond. It is popularly known as carborundum since it was first manufactured as an abrasive in 1891, produced by the fusion of high grade silica and petroleum coke with sawdust. For many years silicon carbide was thought not to give rise to pulmonary lesions. Recently several researchers suggested the existence of a carborundum pneumoconiosis. The aim of this study was to evaluate the role of the pulmonary clearance of 99m Technetium chelated to diethylene-triamine penta-acetate (99m Tc DTPA), and 67 Gallium lung scanning in workers exposed to abrasive dusts. Thirty seven subjects, 13 smokers and 24 nonsmokers and ex smokers were studied. In 32 (86,48%) 67 Gallium lung scanning was positive including 13 (40,62%) retired workers. We conclude that non smoking workers of abrasives plants have a pulmonary alveolar epithelial permeability disturbance similar as observed in smoking workers and smoking controls. Most workers, ex-workers of these industries and in patients with carborundum pneumoconiosis there is an evidence of pulmonary inflammation measured with abnormal 67 Gallium lung scan. (author)

  2. 30 CFR 72.610 - Abrasive blasting.

    Science.gov (United States)

    2010-07-01

    ... respirators approved for abrasive blasting by NIOSH under 42 CFR part 84, or the operation shall be performed... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Abrasive blasting. 72.610 Section 72.610... HEALTH STANDARDS FOR COAL MINES Miscellaneous § 72.610 Abrasive blasting. (a) Surface and...

  3. Asociación entre la presencia de anticuerpos anti-Ras y anti-VPH16 E4/E7 y lesiones intraepiteliales del cérvix Association between anti-Ras and anti-HPV16 E4/E7 antibodies with cervical intraepithelial lesions

    Directory of Open Access Journals (Sweden)

    Sara Vázquez-Corzo

    2003-10-01

    Full Text Available OBJETIVO: Determinar si anticuerpos séricos contra E4, E7 y Ras pueden ser utilizados como marcadores de lesiones tempranas del cérvix uterino asociadas al virus del papiloma humano. MATERIAL Y MÉTODOS: Entre marzo de 1999 y abril de 2000 se realizó un estudio sero-epidemiológico de casos y controles en la clínica de displasias del Hospital General Doctor Gea González, en la Ciudad de México, en 116 muestras de suero para evaluar la presencia de anticuerpos anti-E4, E7 y Ras utilizando un ELISA de captura. Se estimaron razones de momios e intervalos de confianza de 95% RESULTADOS: Anticuerpos anti-E7 se asociaron a mujeres con lesiones NIC III, mientras que anticuerpos anti-E4 y anti-Ras fueron más frecuentes en lesiones NIC I-II. Al evaluar el perfil de anticuerpos que presentaron las mujeres, encontramos que a anticuerpos contra dos proteínas predicen la existencia de una lesión NIC I-II, y b la presencia de tres anticuerpos predicen una lesión NIC III. CONCLUSIONES: La detección de anticuerpos séricos contra E4, E7 y Ras en combinación con otras técnicas de diagnóstico, podrían ser de utilidad para detectar oportunamente a mujeres con lesiones tempranas asociadas al Virus del Papiloma Humano y en riesgo de desarrollar cáncer.OBJECTIVE: To evaluate whether serum antibodies anti-E4, E7 and Ras could be used as markers for early cervical lesions associated with HPV (human papillomavirus. MATERIAL AND METHODS: A seroepidemiological case-control study was conducted between March 1999 and April 2000 at the dysplasia clinic of Hospital General Doctor Gea Gonzalez, in Mexico City, to evaluate the presence of antibodies anti-E4, E7, and Ras through a sandwich ELISA. Analysis was done using odds ratios and 95% confidence intervals. RESULTS: Anti-E7 antibodies were associated to women with CIN III lesions, while anti-E4 and Ras antibodies were strongly associated with CIN I-II lesions. The antibody profile of women with different

  4. p16INK4a在宫颈病变中的研究进展%Progress of P16INK4a in Cervical Lesions

    Institute of Scientific and Technical Information of China (English)

    刘莹; 周瑾

    2011-01-01

    宫颈癌严重威胁女性健康和安全,是导致女性死亡的主要恶性肿瘤之一.近年来我国宫颈癌的发病率正以每年2%~3%的速度增长,因此早期诊断对于预防和治疗宫颈癌具有决定性的意义.p16INK4a是近年来发现的肿瘤抑制基因,是一种细胞周期蛋白D依赖性激酶的抑制剂,研究表明p16INK4a的表达与宫颈癌的发生发展密切相关.目前宫颈癌筛查中的细胞学检查及hr-HPV检测方法 都具有一定的局限性,寻求新的筛查方法 已成为研究热点.p16INK4a的检测技术易于普及、操作简便,不仅能提高宫颈癌的早期诊断率、预测宫颈癌的发生发展,且较HC-Ⅱ检测更能区分是否存在病变,从而降低传统宫颈癌筛查的假阳性率及假阴性率,提高筛查的灵敏度和特异度,为宫颈癌的筛查开辟了新途径,值得进一步深入研究.%Cervical cancer was a serious threat to women's health and safety , which was the leading cause of cancer death for women. In recent years,the incidence of cervical cancer increased 2% -3% per year in China,so an early diagnosis to prevent cervical cancer and the treatment was of decisive importance. As a tumor suppressor gene,pl6INK4a was a recently discovered inhibitor of cyclin D-dependent kinase; studies had shown that the expression of pl6INK4a was closely linked to the development of cervical cancer. Current screening of cervical cytology and detection methods hr-HPV had certain limitations,to seek new screening method had become a research hotspot.pl6INK4a detection technology was easy to spread,easy to use,which can not only improve the early diagnosis of cervical cancer to predict the impact of the development of cervical cancer, and was better than the HC- II test to distinguish the existence of the disease,thus reducing false positives traditional cancer screening cervical rate and false negative rates,and improving the sensitivity and specificity of screening for cervical

  5. Study of the interaction of the risk factors in cervical cancer risk degree and the relationship between HPV genotype and cervical cancer and precancerous lesions%危险因素与宫颈癌发生危险度的交互作用及HPV基因型与宫颈癌及其癌前病变关系的研究

    Institute of Scientific and Technical Information of China (English)

    杨丽霞; 董剑梅

    2015-01-01

    目的:研究危险因素与宫颈癌发生危险度的交互作用及HPV基因型与宫颈癌及其癌前病变关系.方法:宫颈癌患者以及对照组共645例,对其相关资料给予回顾性分析.结果:性传播疾病史、性伴侣数、孕次是引发宫颈癌的危险因素,可是交互作用差异不具有统计学意义(P>0.05);感染以后 CIN Ⅰ危险性较高的 HPV 基因型为HPV-16,HPV-18,HPV-31,HPV-33,HPV-45,HPV-53,HPV-58,HPV-59.结论:宫颈癌行为危险因素与HPV 感染有联合作用.性传播疾病史以及性伴侣数的联合作用增加宫颈癌的发生风险.另外,HPV 感染当中, HPV-52是最为流行的亚型,其次为HPV-16,HPV-18,HPV-33,HPV-53.%Objective:To study the interaction of the risk factors in cervical cancer risk degree and the relationship between HPV genotype and cervical cancer and precancerous lesions.Methods:The patients with cervical cancer and the control group were 645 cases.The related data were given retrospective analysis.Results:The sexually transmitted diseases history,sexual partners number and gravidity were the risk factors for cervical cancer,but the difference of interaction was not statistically significant(P>0.05). The HPV genotypes with higher CIN Ⅰrisk degree after infection were HPV-16,HPV-18,HPV-31,HPV-33,HPV-45,HPV-53, HPV-58,HPV-59.Conclusion:The behavior risk factors of cervical cancer and HPV infection have a combined effect.The combined effect of sexually transmitted diseases history and sexual partners number can increase the occurrence risk of cervical cancer.In addition,in the HPV infection,HPV-52 is the most popular subtype,followed by HPV-16,HPV-18,HPV-33,HPV-53.

  6. [Analysis of the reasons for abandoning the follow-up and treatment process in women with pre-cancerous cervical lesions in the province of Jujuy: implications for health management].

    Science.gov (United States)

    Paolino, Melisa; Arrossi, Silvina

    2012-12-01

    Adequate follow-up and treatment of women with high-grade squamous intraepithelial lesion (HSIL) and cancer is key in reducing cervical cancer mortality. This research study aims to analyze the magnitude of abandonment in the follow-up and treatment process, as well as the reasons for this abandonment, in women with HSIL who received care in public health services in the province of Jujuy in 2010. Secondary sources were analyzed and women were interviewed in their homes. The abandonment rate within the study population was 23.5%. Among these women, 40.5% mentioned organizational problems in the health care system as a reason for abandoning and 30.9% mentioned subjective reasons. Our results have been used in the reorganization of the follow-up and treatment process being carried out in the province. PMID:23681458

  7. A 7-year randomized prospective study of a one-step self-etching adhesive in non-carious cervical lesions. The effect of curing modes and restorative material

    DEFF Research Database (Denmark)

    van Dijken, Jan W V; Pallesen, Ulla

    2012-01-01

    Class V restorations were placed with the self-etching primer Xeno III and a resin composite (Tetric Ceram) or a poly-acid modified resin composite (Dyract AP) in non-carious cervical lesions without intentional enamel involvement. The materials were cured with a conventional continuous light, a soft...... fulfilled at 18 months the full acceptance ADA criteria. Tetric Ceram showed at 7 years a 20.9% loss of retention and Dyract AP a 25.0% loss rate (Log rank p=0.48). The loss rates for the 3 curing techniques: continuous, soft start and pulse delay were 17%, 27.9% and 24.4%, respectively (Log rank p=0...

  8. TCT联合DNA定量细胞学检查对宫颈病变临床诊断价值研究%The study of TCT and DNA quantitive cytology in the diagnosis of cervical lesions.

    Institute of Scientific and Technical Information of China (English)

    刘桂依; 黄艳美

    2011-01-01

    目的 评价宫颈细胞学配合DNA定量细胞学检查对子宫颈病变的诊断价值.方法 2006年2月至2007年12月间在我们中心对2 800例患者行液基薄层细胞学检查(TCT)及DNA定量细胞学检查.TCT或DNA定量细胞学检查异常者,3个月后复查.TCT未明确诊断意义的不典型鳞状上皮细胞(ASCUS)异常者行阴道镜下多点活组织病理检查.结果 TCT异常者302例,占10.79%(302/2 800).ASCUS 194例,占6.93%;低度鳞状上皮内病变(LSIL)34例,占1.21%;高度鳞状上皮(HSIL)内病变18例,占0.64%(18/2 800);鳞癌(SCC)3例,占0.10%.经阴道镜下多点活组织病理检查,诊断符合率较高.结论 采用TCT配合细胞DNA定量分析,因取材方便无创伤,是进行阴道镜下活检前筛查宫颈癌和癌前病变的好方法,可以帮助早发现宫颈癌和宫颈病变.%Objective To evaluate the diagnostic value of cervical cytology combined with DNA quantitive cytology for cervical lesions.Methods From February 2006 to December 2007, 2,800 patients were examined with liquid - based ThinPrep cytologic test ( TCT ) and DNA quantitative cytology. The patients with abnormal TCT or DNA quantitative cytology results were re - examined after three months. The patients with abnormal TCT results and atypical squamous cells of uncertain significance ( ASCUS ) were further examined by colposcopy and multi - site biopsy examinations. Results Abnormal TCT results were found in 302 patients ( 10.79% ), ASCUS, low - grade squamous intraepithelial lesions ( LSIL ), high - grade squamous intraepithelial lesion ( HSIL ) and squamous cell carcinoma ( SCC ) were found in 194 ( 6.93% ), 34 ( 1.21% ),18 ( 0.64% ) and 3 patients ( 0. 10% ), respectively. Pathological examination confirmed inflammation in 198 cases, accounting for 65.56%( 198/302 ) of abnormal TCT. The difference in TCT and human papillomavirus ( HPV ) infection diagnosis was significant ( P < 0.01 ). Conclusion The combined examinations of

  9. 女性不同人群宫颈病变发病状况调查及危险因素分析%Incidence and Risk Factors of Cervical Lesions among Different Famale People

    Institute of Scientific and Technical Information of China (English)

    徐又先; 袁林; 陈广莉

    2012-01-01

    Objective To investigate the incidence of cervical lesions in urban,non-resident and rural population of Liuzhou area and to analyze its relationship with living and sanitation habits. Methods Living and sanitation habit were examined using questionnaire and investigation of the high risk factor of the general condition, the result of gynecology physical examination,analysis of the risk factors and the pathological types of cervical lesions. Results Education level,using tubbing,number of sex partner,smoking, drinking,vaginal douching, washing vulva during menstruation, frequency of vitamin food consumption, were statistically different among three populations. The incidence of CIN was 6. 11%, 11.60% and 10. 37% .respectively. Nonresident and rural females were more popular in urban women, and HPV infection was highest in rural female (29. 0%). The difference of the incidences of HPV and CIN were found among three populations (P<0. 05). After multiple factor non-conditional Logistic regression analysis, early age of first intercourse,multiple sexual partner were the risk factors of cervical lesions. Smoking and drinking showed no correlation with cervical lesions. Conclusion Different living and sanitation habit of urban,rural and non-resident populations may contribute to the difference in incidence of CIN. Individual behavior intervene, especially douching forbidden should be done to reduce the prevalence of CIN.%目的 了解城市人群、流动人群、农村人群宫颈病变发病状况及不同生活、卫生行为对宫颈病变发病的影响.方法 对三组人群行宫颈病变调查和妇检,并行高危因素分析.结果 三组教育程度、盆浴、性伴侣数、吸烟、饮酒、阴道冲洗、经期清洗外阴和食维生素类食物情况差异有统计学意义;宫颈病变检出率分别为6.11%、11.60%、10.37%,流动和农村组高于城市组;HPV感染农村人群(29.0%)和流动人群(21.7%)明显高于城市人群(11.0

  10. Cervical Pap smear study and detection of abnormal epithelial lesions and determination of its accuracy by cytohistological correlation in patients of tertiary care teaching hospital in central India

    Directory of Open Access Journals (Sweden)

    Garima Malpani

    2016-07-01

    Conclusions: Pap smear is a cost effective and sensitive screening method for detection of cancerous, pre-cancerous and non-cancerous lesions of cervix. [Int J Reprod Contracept Obstet Gynecol 2016; 5(7.000: 2312-2316

  11. Common and Rare Causes of Spinal Dumbbell-Shaped Lesions Including a Chondrosarcoma That Primarily Developed in the Cervical Spine: A Case Report

    Directory of Open Access Journals (Sweden)

    Amirhossein Ghazavi

    2009-01-01

    Full Text Available Various neoplastic, vascular and developmental causes may lead to spinal neural foraminal widening. Schwanomas and neurofibromas are the most common causes of spinal dumbbell-shaped lesions. Occasionally, some other slow-growing tumors may cause neural foraminal widening."nWe report an exceptional case of a spinal chondrosarcoma of the neural arcus of C5. The lesion passed through the C4-C5 foramen, producing a dumbbell mass.

  12. Clinical Application of Colposcopy Cervical Biopsy and Liquid-based Cytology Test in the Screening of Cervical Lesions%阴道镜宫颈活检与 TCT 联合检测在宫颈病变中的应用

    Institute of Scientific and Technical Information of China (English)

    冷海娜; 孙名芳

    2013-01-01

    Objective To explore the clinical application value of colposcopy cervical biopsy and liquid -based cytology test in the screening of cervical lesions .Methods Four hundred and eighty-three patients who udergone the TCT examination from January to December in gynecological clinic were chosen for pathological colposcopy cervical biopsy To select 483 gynecological clinic patients who had the TCT examination and were inspected to be abnormal in Care Hospital from January to December ,2012 ,have pathological colposcopy cervical biopsy for them and retrospective a-nalysis fwas carried out .or their entire clinical datum .Among which the TBS diagnostic system wasis used in the TCT in-spection report ,which contributed to the diagnosis ,as well as combined with the pathological examination report to make the diagnosis.Results Among the patients with the TCT result being ASC-US351,CINⅠ~CINⅢ223 patients(63. 53%) were detected with the pathological colposcopy cervical biopsy;CINⅠ~CINⅢ75 patients(91.46%) were de-tected with the pathological colposcopy cervical biopsy;CINⅠ~CIMⅢ41 patients were detected with the pathological colposcopy cervical biopsy and among the 6 SCC patients ,SCC 6 patients were detected with the colposcopy cervical bi-opsy .Conclusion The diagnose accordance rate of TCT examination and cervical biopsy diagnosis is high ;the diagnose accordance rate of cervical cancer with CIN of higher level is high .Precancerous lesions of uterine cervix can be found at an earlier age with the adoption of colposcopic cervical biopsy combined with TCT examination and stopped or slowed down ,which is the safe ,reliable and accurate examination method for the screening of cervical cancer .%目的:探讨阴道镜宫颈活检与宫颈薄层液基细胞学( TCT )在宫颈病变筛查中的临床应用价值。方法选取2012年1月~12月在妇科门诊行宫颈薄层液基细胞学( TCT)检查异常的483例患者,并同时行阴道镜宫颈活检

  13. Cervical Cancer

    Science.gov (United States)

    ... the place where a baby grows during pregnancy. Cervical cancer is caused by a virus called HPV. The ... for a long time, or have HIV infection. Cervical cancer may not cause any symptoms at first. Later, ...

  14. Screening results on cervical lesions with DNA quantitative cytology and liquid-based cytology%DNA定量细胞学配合液基细胞学对宫颈病变筛查的价值

    Institute of Scientific and Technical Information of China (English)

    曹红英; 武卫华; 许振; 许艳梅

    2011-01-01

    OBJECTIVE: To evaluate the value of the DNA quantitative cytology with liquid-based cytology in cervical cancer prevention and treatment. METHODS: 4 352 cases of patients in our hospital outpatient gynecologic from 01-01-2009 to 10-31-2010 were involved in this study. All the 504 cases which were recommended biopsy were conducted colposcopy and biopsy. The pathological changes were observed after the routine HE staining. Then the positive coincidence rate of the liquid-based cytology was calculated with routine HE staining and DNA Feulgen staining with routine HE staining respectively. RESULTS: The positive rate was 52. 18% (263/504) with the diagnosis of the TBS biopsy criteria. The positive rate was 66.67%(336/504) with the diagnosis of the DNA Feulgen staining biopsy criteria, While the positive rate was 81.75 % (412/504) with the diagnosis of the two combined cytological method biopsy criteria. There was significant difference among the three methods (P<0. 05). CONCLUSIONS: DNA Feulgen staining compared with the single liquid-based cytology, the rate of early detection of cervical lesions is improved significantly. The false negative rate of thc liquid-based cytology can be reduced by the combination of the two, but also the detection rate of cervical lesions of early can be improved. It plays a posive role in order to prevent further development of lesions of early cervical cancer.%目的:评价DNA定量细胞学配合液基细胞学检查在宫颈癌防治中的价值.方法:收集2009-01-01-2010-10-31在我院妇科门诊行液基细胞学及DNA定量检查的患者4 352例,对检查结果建议为活检的病例504例行阴道镜检查及活体组织检查,常规HE染色后观察病变程度,分别计算其与液基细胞学和DNA Feulgen染色后的阳性率.结果:以TBS活检标准行活检病例的阳性检出率为52.18%(263/504),以DNA定量分析结果活检标准行活检的病例阳性检出率为66.67%(336/504),经2种细胞学方法联

  15. Management of squamous cell carcinoma in cervical lymph nodes in the clinical absence of primary lesion by combined surgery and irradiation

    International Nuclear Information System (INIS)

    Sixty-three patients who had either previously treated primary tumors or unknown primary tumors and developed metastatic cervical adenopathy in their previously untreated necks received the combination of surgery and megavoltage irradiation. Within two years, 12 patients died of intercurrent disease, nine patients died with distant metastastases only, and five patients had disease recur at a primary site. The remaining 37 patients were evaluable for control of neck disease; 26 patients had previous treatment to a primary head and neck cancer that was under control at the time cervical adenopathy was treated; and 11 patients had an unknown primary tumor that was believed to be in the head and neck area. The combination of pre- or postoperative irradiation and surgery controlled neck disease in 86% of the evaluable patients. Because of the extent of neck disease, these patients would have been at a high risk of failure in the treated area if only a single modality of treatment were uognostic variables, in addition to treatment, were pretreatment performance status and pretreatment CEA level. The toxic reactions related to the treatment are discussed

  16. The management of squamous cell carcinoma in cervical lymph nodes in the clinical absence of a primary lesion by combined surgery and irradiation

    International Nuclear Information System (INIS)

    Sixty-three patients who had either previously treated primary tumors or unknown primary tumors and developed metastatic cervical adenopathy in their previously untreated necks received the combination of surgery and megavoltage irradiation. Within two years, 12 patients died of intercurrent disease, nine patients died with distant metastases only, and five patients had disease recur at a primary site. The remaining 37 patients were evaluable for control of neck disease; 26 patients had previous treatment to a primary head and neck cancer that was under control at the time cervical adenopathy was treated; and 11 patients had an unknown primary tumor that was believed to be in the head and neck area. The combination of pre- or postoperative irradiation and surgery controlled neck disease in 86% of the evaluable patients. Because of the extent of neck disease, these patients would have been at a high risk of failure in the treated area if only a single modality of treatment were used. Analysis of the data shows an association of extranodal connective tissue involvement with both a decreased rate of control within the treated area and distant metastases

  17. Progression of HPV infection to detectable cervical lesions or clearance in adult women: Analysis of the control arm of the VIVIANE study

    Science.gov (United States)

    Wheeler, Cosette M.; Romanowski, Barbara; Castellsagué, Xavier; Lazcano‐Ponce, Eduardo; Rowena Del Rosario‐Raymundo, M.; Vallejos, Carlos; Minkina, Galina; Pereira Da Silva, Daniel; McNeil, Shelly; Prilepskaya, Vera; Gogotadze, Irina; Money, Deborah; Garland, Suzanne M.; Romanenko, Viktor; Harper, Diane M.; Levin, Myron J.; Chatterjee, Archana; Geeraerts, Brecht; Struyf, Frank; Dubin, Gary; Bozonnat, Marie‐Cécile; Rosillon, Dominique; Baril, Laurence

    2016-01-01

    The control arm of the phase III VIVIANE (Human PapillomaVIrus: Vaccine Immunogenicity ANd Efficacy; NCT00294047) study in women >25 years was studied to assess risk of progression from cervical HPV infection to detectable cervical intraepithelial neoplasia (CIN). The risk of detecting CIN associated with the same HPV type as the reference infection was analysed using Kaplan–Meier and multivariable Cox models. Infections were categorised depending upon persistence as 6‐month persistent infection (6MPI) or infection of any duration. The 4‐year interim analysis included 2,838 women, of whom 1,073 (37.8%) experienced 2,615 infections of any duration and 708 (24.9%) experienced 1,130 6MPIs. Infection with oncogenic HPV types significantly increased the risk of detecting CIN grade 2 or greater (CIN2+) versus non‐oncogenic types. For 6MPI, the highest risk was associated with HPV‐33 (hazard ratio [HR]: 31.9 [8.3–122.2, p 25 years in this study was similar to that in women 15–25 years in PATRICIA. PMID:26685704

  18. Progress in abrasive and grinding technology

    CERN Document Server

    Xu, Xipeng

    2009-01-01

    The grinding and abrasive processing of materials are machining techniques which use bonded or loose abrasives to remove material from workpieces. Due to the well-known advantages of grinding and abrasive processes, advances in abrasive and grinding technology are always of great import in enhancing both productivity and component quality. In order to highlight the recent progress made in this field, the editor invited 21 world-wide contributions with the aim of gathering together all of the achievements of leading researchers into a single publication. The authors of the 21 invited papers, of

  19. Abrasion of flat rotating shapes

    OpenAIRE

    Roth, A.E.; Marques, C. M.; Durian, D. J.

    2010-01-01

    We report on the erosion of flat linoleum "pebbles" under steady rotation in a slurry of abrasive grit. To quantify shape as a function of time, we develop a general method in which the pebble is photographed from multiple angles with respect to the grid of pixels in a digital camera. This reduces digitization noise, and allows the local curvature of the contour to be computed with a controllable degree of uncertainty. Several shape descriptors are then employed to follow the evolution of dif...

  20. HPV vaccination and allocative efficiency: regional analysis of the costs and benefits with the bivalent AS04-adjuvanted vaccine, from the perspective of public health, for the prevention of cervical cancer and its pre-cancerous lesions

    Directory of Open Access Journals (Sweden)

    Paolo Bonanni

    2012-11-01

    Full Text Available Introduction: by means of the decisions on whether to introduce the HPV vaccination, Public Health has already established the importance of associating the vaccination strategy to the policy of secondary prevention. The screening + vaccination strategy is more effective than the two methods taken individually. In support of this combined strategy and in order to make available per each region concrete elements for their regional planning, an assessment has been made, which also takes into account the effect of cross-protection regarding high-risk strains not contained in both vaccines, bivalent and quadrivalent, and more frequently responsible for pre-cancerous lesions and cervical cancer (CCU. This analysis evaluates the costs and benefits of screening + vaccination strategy in a 12-year-old female cohort. Furthermore, the paper provides results that may be useful to assess the opportunity to extend the vaccination to a second cohort of 24-25-year-old women. The analysis is preceded by a brief summary of CCU epidemiology available data, public health policies that give precise guidelines for vaccination strategies and analytical tools suitable to support public policy makers to efficiently allocate resources. Methods: two different models were used for two regional analyses.The vaccines may have different sustained- and cross-protection levels against non-vaccine oncogenic HPV-types. In the first analysis, a prevalence-based model estimated the potential net difference in HPV-related lesions (abnormal pap smear, cervical intraepithelial neoplasia (CIN, cervical cancer (CC and genital warts (GW and associated costs generated by the two vaccines. Vaccine efficacy rates were based on published data for each vaccine. Lifetime vaccine efficacy was assumed. Results are reported over one year after reaching a steady state. Incidence and treatment costs were obtained from Italian and European sources. We also performed a cost-effectiveness analysis

  1. Lesões precursoras do câncer cervicouterino: evolução histórica e subsídios para consulta de enfermagem ginecológica Lesiones precursoras del cáncer cervical-útero: evolución histórica consolidando la consulta de enfermería ginecológica Cervical-uterine cancer precursor lesions: historical evolution supporting the gynecological nursing consultation

    Directory of Open Access Journals (Sweden)

    Maria Cristina de Melo Pessanha Carvalho

    2010-09-01

    Full Text Available Estudo emergido de recorte de dissertação de mestrado, ilustrando a evolução histórica das lesões precursoras do câncer cervicouterino (LPCCU. Trata-se da história das LPCCU, delineando a relevância do conhecimento para prática do enfermeiro na área da saúde da mulher. O conceito de LPCCU inicia-se a partir do século XIX, dando início aos estudos das células alteradas. Objetivo: descrever as diversas fases da evolução histórica das alterações cervicais. Estudo qualitativo, descritivo-analítico, recorte temporal no período de 1940 a 2008. Dados levantados mediante bibliografia de fonte primária e recurso BIREME. Pontuaram-se as classificações que já existiram, destacando a Nomenclatura Brasileira, importante para corresponder às necessidades e o perfil da saúde das mulheres do Brasil. Este estudo é o ponto de partida para respaldar as práticas de consulta de enfermagem ginecológica com abordagens educativas, contemplando a população feminina em ações preventivas e incentivo ao tratamento.Estudio emergido de recorte de disertación de máster, ilustrando la evolución histórica de las lesiones precursoras del cáncer cervical-uterino (LPCCU. Se trata de la historia de las LPCCU, delineando la relevancia del conocimiento para la práctica del enfermero en cuidados en la salud de la mujer. El concepto de LPCCU se inicia a partir del siglo XIX, empezando los estudios de las células alteradas. Como objetivo: describir las diversas fases históricas de las alteraciones cervicales. Estudio cualitativo, descriptivo-analítico, recorte temporal en el período de 1940 hasta 2008. Datos acrecentados mediante bibliografía de fuente primaria y recurso BIREME. Se puntuó las diferentes clasificaciones que ya existieron, conde destaque para la nomenclatura brasileña, importante para corresponder a las necesidades y el perfil de la salud de las mujeres del Brasil. Esto estudio es el ponto de partida para respaldar las pr

  2. Utilidad en la combinación de oligonucleótidos universales para la detección del virus del papiloma humano en cáncer cervicouterino y lesiones premalignas Usefulness of combining universal oligonucleotides in detecting human papillomavirus in cervical cancer and premalignant lesions

    Directory of Open Access Journals (Sweden)

    Adela Carrillo

    2004-02-01

    Full Text Available OBJETIVO: Determinar la frecuencia y distribución del virus del papiloma humano en los diferentes estadios que conforman la historia natural del cáncer cérvico uterino, y optimizar la detección mediante el uso de diferentes oligonucleótidos universales. MATERIAL Y MÉTODOS: Se trata de un estudio transversal, descriptivo, en el que las muestras fueron colectadas durante enero a diciembre de 1999. El procesamiento de las muestras y el análisis de los datos se realizaron en el Instituto Nacional de Cancerología en la Ciudad de México. Se hizo análisis comparativo con t de Student para valores continuos y con ji cuadrada para proporciones, y análisis de concordancia entre biopsia y exudado cervical con la prueba estadística de Kappa. Para la detección del virus se utilizó la técnica de la reacción en cadena de la polimerasa (PCR con oligonucleótidos universales los cuales reconocen diferentes regiones del gen L1 (MY09/11; GP5/6; L1C1/2, y oligonucleótidos específicos para el VPH 16 y el VPH 18, así como secuenciación directa de los productos de la PCR. RESULTADOS: Se analizaron 154 muestras: 65 (42.2% citologías normales, 45 (29.2% lesiones de alto y bajo grado, y 44 (28.6% de cáncer invasor. El VPH fue detectado en 95.5% de los casos de cáncer invasor, en 91.6% de lesiones de alto grado, en 66.7% de lesiones de bajo grado y en 23.1% de citologías normales, por la PCR con al menos uno de los juegos de oligonucleótidos utilizados. La detección fue más eficiente en las muestras obtenidas por biopsia que en los exudados cervicovaginales. El porcentaje total de detección del VPH con un juego de oligonucleótidos universales (37.6% aumentó sustancialmente (60.4% al combinarlo con otros dos juegos de oligonucleótidos universales. CONCLUSIONES: La presencia del VPH de alto riesgo es elevada inclusive en mujeres con epitelios cervicales con diagnóstico citológico normal. La detección del VPH mejora al utilizar distintos

  3. HPV prevalence and type-distribution in cervical cancer and premalignant lesions of the cervix: A population-based study from Northern Ireland.

    Science.gov (United States)

    Anderson, Lesley A; O'Rorke, Michael A; Wilson, Robbie; Jamison, Jackie; Gavin, Anna T

    2016-07-01

    Assessment of Human papillomavirus (HPV) prevalence and genotype distribution is important for monitoring the impact of prophylactic HPV vaccination. This study aimed to demonstrate the HPV genotypes predominating in pre-malignant and cervical cancers in Northern Ireland (NI) before the vaccination campaign has effect. Formalin fixed paraffin embedded tissue blocks from 2,303 women aged 16-93 years throughout NI were collated between April 2011 and February 2013. HPV DNA was amplified by PCR and HPV genotyping undertaken using the Roche(®) linear array detection kit. In total, 1,241 out of 1,830 eligible samples (68.0%) tested positive for HPV, with the majority of these [1,181/1,830 (64.5%)] having high-risk (HR) HPV infection; 37.4% were positive for HPV-16 (n = 684) and 5.1% for HPV-18 (n = 93). HPV type-specific prevalence was 48.1%, 65.9%, 81.3%, 92.2%, and 64.3% among cervical intraepithelial neoplasias (CIN) Grades I-III, squamous cell carcinomas (SCC) and adenocarcinoma (AC) cases, respectively. Most SCC cases (81.3%) had only one HPV genotype detected and almost a third (32.0%) of all cervical pathologies were HPV negative including 51.9% of CIN I (n = 283), 34.1% CIN II (n = 145), 18.7% of CIN III (n = 146), 7.8% of SCC (n = 5), and 35.7% of AC (n = 5) cases. This study provides important baseline data for monitoring the effect of HPV vaccination in NI and for comparison with other UK regions. The coverage of other HR-HPV genotypes apart from 16 and 18, including HPV-45, 31, 39, and 52, and the potential for cross protection, should be considered when considering future polyvalent vaccines. J. Med. Virol. 88:1262-1270, 2016. © 2015 Wiley Periodicals, Inc. PMID:26680281

  4. Transition metal carbide and boride abrasive particles

    International Nuclear Information System (INIS)

    Abrasive particles and their preparation are discussed. The particles consist essentially of a matrix of titanium carbide and zirconium carbide, at least partially in solid solution form, and grains of crystalline titanium diboride dispersed throughout the carbide matrix. These abrasive particles are particularly useful as components of grinding wheels for abrading steel. 1 figure, 6 tables

  5. 30 CFR 58.610 - Abrasive blasting.

    Science.gov (United States)

    2010-07-01

    ... miners shall use in accordance with 30 CFR 56.5005 or 57.5005 respirators approved for abrasive blasting by NIOSH under 42 CFR part 84, or the operation shall be performed in a totally enclosed device with... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Abrasive blasting. 58.610 Section...

  6. Ultrasonic Abrasive Removal Of EDM Recast

    Science.gov (United States)

    Mandel, Johnny L.; Jacobson, Marlowe S.

    1990-01-01

    Ultrasonic abrasive process removes layer of recast material generated during electrical-discharge machining (EDM) of damper pocket on turbine blade. Form-fitted tool vibrated ultrasonically in damper pocket from which material removed. Vibrations activate abrasive in pocket. Amount of material removed controlled precisely.

  7. The Distribution and Infection of HPV in Cervical Biopsy Lesions among 450 Women%450例宫颈活检组织中人乳头瘤病毒的分布特征

    Institute of Scientific and Technical Information of China (English)

    王翔; 钱福初; 顾栋桦; 秦基取; 陈瑜; 李雄峰

    2011-01-01

    [Objective] To determine the distribution and infection of HPV in cervical cancer and precancerous lesions. [Methods]Four hundred patients with abnormal cytology were examined by colposcopy. HPV diagnosis was done by polymerase chain reaction using MY09/MY11 primers, for genotyping blot hybridization was used. The pathological results confirmed standards. [Result]A total of 294 women were HPV-DNA positive. HPV-16 was found in 36.7% of all women with positive HPV-DNA,HPV58 in 22. 1%, HPV-18 in 18.7% and HPV-52 in 16. 0%. The infection of HPV in lesions with cervicitis, CIN Ⅰ , CIN Ⅱ and CIN Ⅲ were 55.6 %, 69 %, 82.7 % and 88.9%, respectively. HPV-16,-58,-18 and -52 were found in different cervical lesions. [Conclusions] The finding of HPV-58 and -52 expects HPV-16 and -18 among Huzhou women with CIN Ⅱ and CIN Ⅲ , and has important implications for the development of type-common HPV vaccines.%[目的]了解阴道镜检查患者的宫颈活检组织中HPV的感染率和亚型分布.[方法]对宫颈脱落细胞学异常的患者450例进行阴道镜下定位活检.活检组织同时行HPV基因分型和病理诊断,HPV基因分型采用斑点杂交方法进行.[结果]在450例宫颈活检患者中,其HPV感染率为65.3%.在HPV-DNA阳性患者中,检出率最高的HPV-16占36.7%,依次HPV-58为22.1%,HPV-18为18.7%,HPV-52为16.0%.在宫颈炎、CIN Ⅰ、CIN 、Ⅱ、D,CIN Ⅲ中HPV-DNA阳性率分别为55.6%、69%、82.7%和88.9%.在宫颈炎、CIN Ⅰ、CIN Ⅱ、CIN Ⅲ组织中均检测到HPV-16、-58、-18和-52.[结论]本研究中的宫颈活检组织中不仅检测到HPV-16和-18,还检测到HPV-58和-52感染,后者的发现为开发宫颈癌多价复合型疫苗提供了事实依据.

  8. Corneal abrasions associated with pepper spray exposure.

    Science.gov (United States)

    Brown, L; Takeuchi, D; Challoner, K

    2000-05-01

    Pepper spray containing oleoresin capsicum is used by law enforcement and the public as a form of nonlethal deterrent. Stimulated by the identification of a case of a corneal abrasion associated with pepper spray exposure, a descriptive retrospective review of a physician-maintained log of patients presenting to a jail ward emergency area over a 3-year period was performed. The objective was to give some quantification to the frequency with which an emergency physician could expect to see corneal abrasions associated with pepper spray exposure. Of 100 cases of pepper spray exposure identified, seven patients had sustained corneal abrasions. We conclude that corneal abrasions are not rare events when patients are exposed to pepper spray and that fluorescein staining and slit lamp or Wood's lamp examination should be performed on all exposed patients in whom corneal abrasions cannot be excluded on clinical grounds. PMID:10830682

  9. A evaluation on cervical intraepithelial lesion and cervical cancer screening by DNA quantitative analysis and liquid-based monolayer cytology%液基薄层细胞学联合DNA定量方法对宫颈病变诊断试验的评价

    Institute of Scientific and Technical Information of China (English)

    侯安丽; 张玉娟; 李秀芬; 邵雪斋; 王杏茶

    2012-01-01

    mistake diagnostic rate,omission diagnostic rate and negative likelihood ratio arc lower than liquid-based monolaycr cytology. The combining sensitivity and the combining specificity of parallel tests between DNA quantitative analysis and liquid-based monolaycr cytology were 99. 56%、44. 52% respectively. The combining sensitivity and the combining specificity of serial tests between the two methods were 83. 78% \\89. 61 %, respectively. The sensitivity of parallel tests is the highest, The specificity of serial tests is the highest. Conclusion Liquid-based monolaycr cytology combined with quantitative DNA analysis may increase the sensitivity and specificity of cervical prccanccrous lesions and early cervical carcinoma.

  10. Genetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China

    International Nuclear Information System (INIS)

    High-risk human papillomavirus type 16 (HPV16) is a risk factor for cervical cancer. Previous studies suggest that polymorphisms in the E6 gene or the long control region(LCR)of HPV16 may alter the oncogenic potential of the virus. The aims of this study were to investigate the genetic variations of HPV16 E6 gene and LCR in isolates from Chinese population and correlation of the E6 and LCR polymorphisms with disease status of infected patients. HPV16 positive endocervical specimens were collected from 304 women living in Northeast of China. Sequences of E6 gene and LCR were analyzed by PCR-sequencing. Two lineages were found in the populations, including EUR lineage and As lineage. Based on the HPV16 prototype, the most frequent variation in the E6 gene was T178A/G (48.7%), followed by mutations of G94A (12.2%) and T350G (9.9%). The rank orders of incidence of E6 variations in amino acid were as follows: D25E (46.3%), L83V (9.9%) and H78Y (4.3%). Nucleotide variations in LCR were found in all the 304 isolates from HPV16 positive cervical samples. The most commonly observed LCR variations were the transition replacement G7193T, 7434CIns, G7521A and 7863ADel (100%). The As lineage was associated with HPV persistent infections and with disease status of ≥CIN2,3. The EUR lineage variants showed a negative trend of association with the severity of ≥CIN2,3. Among 41 variations found in LCR, 25 (61.0%) were located at the binding sites for transcription factors. Occurrence of ≥CIN2,3 was significantly associated with the mutations of R10G/L83V in E6 and the C7294T co-variation in LCR, after adjusting for ages of infected patients. Associations between As lineage and HPV persistent infections, and with disease status of ≥CIN2,3, and an association between the EUR lineage and negative trend of association with the severity of ≥CIN2,3 were found in this study. An association between a co-variation of R10G/L83V in E6 and C7294T in LCR and an increased risk for

  11. Cervical myositis ossificans traumatica: a rare location

    Energy Technology Data Exchange (ETDEWEB)

    Baysal, T.; Sarac, K.; Kutlu, R. [Dept. of Radiology, Inonu University, Malatya (Turkey); Baysal, O.; Ersoy, Y. [Dept. of Physical Therapy and Rehabilitation, Inonu Univ., Malatya (Turkey); Elmali, N. [Dept. of Orthopedics and Traumatology, Inonu Univ., Malatya (Turkey)

    1999-05-01

    An unusual case of myositis ossificans traumatica lesion located in the paraspinal region is reported. Despite the contiguity of the lesion with the cervical vertebrae and ominous appearance of the biopsy material, the history of antecedent trauma and computed tomography findings allowed preoperative accurate diagnosis. To our knowledge, myositis ossificans traumatica located in the cervical paraspinal region is very rare. (orig.) With 4 figs., 16 refs.

  12. Diagnosis of cervical disc disease

    International Nuclear Information System (INIS)

    High resolution CT easily localized lesions including soft tissues of the bone such as disc protrusion and thickening of the yellow ligament. In all cases, myelography demonstrated compression of the nerve roots of the spinal cord which corresponded to CT findings at the level where plain CT revealed a lesion. However, CT metrizamide myelography demonstrated the lesion more clearly than did conventional myelography. CT metrizamide myelography also outlined compression of the nerve roots satisfactorily and demonstrated compressed findings of the spinal cord in the dynamic study. Thus, high resolution CT was useful for screening of cervical disc disease, and CT metrizamide myelography, for identification of lesions of the nerve roots. (Chiba, N.)

  13. Cervical radiculopathy.

    Science.gov (United States)

    Iyer, Sravisht; Kim, Han Jo

    2016-09-01

    Cervical radiculopathy is a common clinical scenario. Patients with radiculopathy typically present with neck pain, arm pain, or both. We review the epidemiology of cervical radiculopathy and discuss the diagnosis of this condition. This includes an overview of the pertinent findings on the patient history and physical examination. We also discuss relevant clinical syndromes that must be considered in the differential diagnosis including peripheral nerve entrapment syndromes and shoulder pathology. The natural history of cervical radiculopathy is reviewed and options for management are discussed. These options include conservative management, non-operative modalities such as physical therapy, steroid injections, and operative intervention. While the exact indications for surgical intervention have not yet been elucidated, we provide an overview of the available literature regarding indications and discuss the timing of intervention. The surgical outcomes of anterior cervical decompression and fusion (ACDF), cervical disc arthroplasty (CDA), and posterior cervical foraminotomy (PCF) are discussed. PMID:27250042

  14. 5-type HPV mRNA versus 14-type HPV DNA test: test performance, over-diagnosis and overtreatment in triage of women with minor cervical lesions

    OpenAIRE

    Westre, Bjørn; Giske, Anita; Guttormsen, Hilde; Sørbye, Sveinung Wergeland; Skjeldestad, Finn Egil

    2016-01-01

    Background Repeat cytology and HPV testing is used in triage of women with minor cytological lesions. The objective of this study was to evaluate 14-type HPV DNA and 5-type HPV mRNA testing in delayed triage of women with ASC-US/LSIL. Methods We compared a DNA test (Roche Cobas 4800) and an 5-type mRNA test (PreTect HPV-Proofer). In total 564 women were included in the study. Results The sensitivity among solved cases for CIN3+ were 100 % (15/15) for both tests. The sensitivity for CIN2+ of t...

  15. Expresi??n de ant??genos HLA clase I e infecci??n por papilomavirus humano tipo 16 en la neoplasia cervical uterina y lesiones precursoras

    OpenAIRE

    Torres Garc??a, Luis Manuel

    1992-01-01

    Sobre una casu??stica de 109 diagn??sticos de diferentes entidades nosologicas de cervix uterino, se determina la presencia de ant??genos hla clase i mediante la t??cnica de la inmunoperoxidasa, encontrando que tanto el epitelio normal como los condilomas y las lesiones intraepiteliales conservan la expresi??n de estos ant??genos, mientras que los tumores invasores pierden esta capacidad en el 15% de los casos, correlacion??ndose con la invasi??n del estroma y un aumento de su malignidad. Se ...

  16. The role of HPV genotyping test and liquid-based cytology in diagnosis of cervical pre-cancerous lesions%人乳头瘤病毒分型基因检测和液基细胞学检查在宫颈癌前病变中的诊断作用

    Institute of Scientific and Technical Information of China (English)

    谢芳; 黎云; 彭秀红; 李洁明

    2011-01-01

    Objective To evaluate the role and significance of HPV genotyping detection and Thinprep cytology test (TCT ) in the diagnosis of cervical precancerous lesions ( mild to moderate epithelial neoplasia ). Methods The findings of HPV genotyping and TCT were analyzed in 401 patients with cervical precancerous lesions ( CIN1-CIN2 ) who had been hospitalized between November 2008 to November 2010. Results The sensitivity of HPV genotyping was significantly higher than that of TCT ( P<0.01 ).TCT combined with HPV genotyping enhanced the detection rate of cervical lesions. Subtypes 16, 52, 58, and 18 of HPV were common in high-risk HPV infection with cervical precancerous lesions. Subtype 16 had a markedly higher rate of occurrence of cervical lesions than subtypes 52 and 58 ( P < 0.01 ). Conclusions High-risk HPV infection is the major pathogenic factor for cervical cancer and precancerous lesions. HPV 16 infection easily leads to cervical lesion. HPV genotyping test combined with Thinprep cytology test can increase the detection rate of cervical precancerous lesions.%目的 评估人乳头瘤病毒(HPV)基因分型检测和液基细胞学检查(TCT)在宫颈轻、中度上皮细胞内瘤变(CIN1-CIN2)中的诊断作用及意义.方法 对我院2008年11月-2010年11月期间401例因宫颈癌前病变(CIN1-CIN2)要求官颈环切的患者的HPV分型基因检测情况与液基细胞学检查结果进行总结分析.结果 HPV的灵敏性较TCT明显增高(P<0.01),TCT和HPV基因分型检测结合能提高宫颈病变的检出率;宫颈癌前病变中HPV感染以高危基因组的16、52、58、18亚型感染多见,HPV16犁感染引起高度病变的几率较HPV52型和HPV58型明显增高(P<0.01).结论 高危HPV感染是宫颈癌及癌前病变发病的主要致病因子,HPV16型感染易导致宫颈高度病变;HPV基因分型检测和液基细胞学检查结合,可以提高宫颈癌前病变的检出率.

  17. Study of human papillomavirus infection and cervical intraepithelial lesion in HIV/AIDS%HIV/AIDS与人乳头瘤病毒感染及宫颈病变的相关性研究

    Institute of Scientific and Technical Information of China (English)

    郭晓峰; 李晶; 戴卫东

    2013-01-01

    Objective:To determine the characteristics of high-risk type of human papillomavirus (HR-HPV)infection and cervical lesion in HIV/AIDS patients.To provide clues and evidence for the prevention and treatment of cervical cancer in HIV/AIDS patients.Methods:166 HIV/AIDS patients and 476 non-HIV patients from Apr.2009 to Jul.2012 were analyzed to compare the results of HR-HPV and TCT test.Results:The infection ratio of HIV (+) group was significant higher than HIV (-) group.20 cases of HIV (+) group received cervical biopsy,in which 13 cases (65.00%) were diagnosed above CIN Ⅰ level.21 cases of HIV(-) received cervical biopsy,in which 19 cases (90.48%) were proven above CIN Ⅰ level.Among HIV patients,there were significant differences in the number of patients with CD4+ less than 200cell/ul between HR-HVP (+) and HR-HPV (-) patients (P=0.030).Conclusions:The risk of HR-HPV infection in HIV/AIDS patients is much higher than that of non-HIV infected patients.Continuous observation should be conducted on HIV-HPV co-infected patients.The existence of HR-HPV infection may depends on functions of immune svstem.%目的:探讨艾滋病病毒感染者/艾滋病患者(HIV/AIDS)生殖道高危型人乳头瘤病毒(HR-HPV)感染及宫颈病变的特点,为HIV/AIDS患者宫颈癌的防治研究提供线索和依据.方法:选取2009年4月至2012年7月就诊于我院的166例HIV/AIDS患者[HIV(+)组]与476例非HIV感染患者[HIV(-)组],比较两组患者的HR-HPV感染率及液基细胞学检测(TCT)检测结果.结果:HIV(+)组的HR-HPV感染率(38.55%,64/166)显著高于HIV(-)组(10.50%,50/476)(P<0.001).HIV(+)组中20例行宫颈活检,其中13例(65.00%)发生CIN Ⅰ以上病变;HIV(-)组中21例行宫颈活检,19例(90.48%)发生CIN Ⅰ以上病变.HIV(+)组中HR-HPV(+)与HR-HPV(-)者的CD4<200cell/μl的比率分别为29.29%和17.48%,差异显著(P=0.03).结论:HIV/AIDS患者感染HR-HPV的风险显著高于非HIV感染者,对HIV-HPV联合感染

  18. HPV-DNA和TCT检测在宫颈癌前病变筛查中的诊断价值%Diagnostic Value of HPV-DNA and TCT Test in Screening of Cervical Lesions

    Institute of Scientific and Technical Information of China (English)

    张汉园; 沈丽萍; 曹风华; 施瑜; 盈丽霞

    2012-01-01

    目的:探讨乳头瘤病毒定性检测( HPV- DNA)与液基薄层细胞学检查技术(TCT)在宫颈癌前病变中的诊断价值.方法:分别采用HPV- DNA及TCT法检测1536例患者,对TCT阳性、HPV- DNA阳性病例者进行阴道镜下活检.结果:随着病理诊断级别的升高,高危型HPV感染率上升,而低危型HPV感染多见于轻度不典型增生(CINⅠ)及其以下病变,HPV混合感染在各组间未见明显趋势.HPV-DNA检测与宫颈活检的符合率为66.78%.随着病理级别的升高,不典型鳞状细胞(ASCUS)组的感染率呈降低趋势,鳞状上皮内低度病变(LSIL)组感染率亦呈下降趋势,而鳞状上皮内高度病变(HSIL)组和鳞癌(SCC)组感染率均呈上升趋势,TCT检测与组织学诊断的符合率为66.67%,与HPV-DNA检查比较,差异无统计学意义(x=0.001,P>0.05).结论:HPV-DNA、TCT及宫颈活检三者检测相结合,能明显提高诊断的正确性.%Objective: To study the clinical application value of the qualitative detection of human papillomavirus (HPV-DNA) and ThinPrep cytology technique (TCT) in prevention of cervical lesions and cervical cancer. Methods: Totally 1536 cases were screened by HPV-DNA test or TCT test. Directed biopsies under colposcopy were taken either in both positive test. Results: The pathological diagnosis level rose when high-risk HPV infection increased, while low-risk HPV infection was appeared more commonly in CIN I lesions, but HPV co-infection had no significant trend in each group. The compliance rate of HPV-DNA testing with the histological diagnosis was 66.78%. With the increased pathological grade, ASCUS group infection rate was decreasing, and LSIL group infection rate was also found a downward trend, while the prevalence of HSIL group and SCC group were rising. The compliance rate of TCT test with the histological diagnosis was 66.67 %, and there was no significantly difference between HPV-DNA test and TCT test (X2 = 0.001, P> 0.05). Conclusion: The

  19. Life cycle and sustainability of abrasive tools

    CERN Document Server

    Linke, Barbara

    2016-01-01

    This monograph focuses on abrasive tools for grinding, polishing, honing, and lapping operations. The book describes the life cycle of abrasive tools from raw material processing of abrasive grits and bonding, manufacturing of monolithic or multi-layered tools, tool use to tool end-of-life. Moreover, this work highlights sustainability challenges including economic, environmental, social and technological aspects. The target audience primarily comprises research and industry experts in the field of manufacturing, but the book may also be beneficial for graduate students.

  20. Clinical value of high-risk human papillomavirus DNA test,liquid-based cytology test in diagnosis of cervical cancer and precancerous lesion%高危型人乳头状瘤病毒DNA、液基薄层细胞检测在宫颈癌及前期病变诊断中的临床价值

    Institute of Scientific and Technical Information of China (English)

    杨秀珍

    2014-01-01

    Objective To investigate the clinical significance of high-risk human papillomavirus (HPV) DNA test com-bined with cytology inspection in the screening of cervical precancerous lesions. Methods 5080 women were selected from February 2013 to January 2014 in our hospital,they were given screen of cervical precancerous lesions.Cervical cytology,high-risk HPV DNA testing,colposcopy and cervical biopsy were done in them,and the results were analyzed with statistical methods. Results ASC-US (atypical squamous meaning is not clear epithelial cells) group of 318 cases, LSIL (low-grade squamous intraepithelial lesions) 26 cases of group,HSIL (high-grade squamous intraepithelial lesion) group of 52 cases,6 cases of invasive group confirmed by histopathological examination. Sensitivity and negative predic-tive value of HPV +TCT (liquid-based cytology test) to detect cervical lesions were higher than those high-risk HPV DNA and TCT,the specificity of TCT detection of cervical lesions was higher than high-risk HPV DNA and HPV DNA+ TCT,the difference was significant (P<0.05). Conclusion The sensitivity and negative predictive value of high-risk HPV DNA testing combined with cytology testing in the cervical cancer screening are higher,and has positive im-plications for screening for cervical lesions.%目的:探讨高危型人乳头状瘤病毒(HPV)DNA检测联合宫颈细胞学检查对宫颈癌前病变筛查的临床意义。方法5080名女性均在2013年2月~2014年1月选择在本院就诊并进行宫颈癌前病变筛查,对其进行宫颈细胞学检查、高危型HPV DNA检测、阴道镜下行宫颈活检,使用统计学方法分析检测结果。结果经组织病理检查确诊ASC-US(不能明确意义的非典型鳞状上皮细胞)组318例,LSIL(低度鳞状上皮内病变)组26例,HSIL(高度鳞状上皮内病变)组52例,浸润癌组6例,HPV DNA+液基薄层细胞检测(TCT)检测宫颈病变的灵敏度及阴性预测值高于高危型HPV DNA检测及TCT,TCT

  1. Cervical cancer screening at crossroads

    DEFF Research Database (Denmark)

    Lynge, Elsebeth; Rygaard, Carsten; Baillet, Miguel Vazquez-Prada;

    2014-01-01

    Cervical screening has been one of the most successful public health prevention programmes. For 50 years, cytology formed the basis for screening, and detected cervical intraepithelial lesions (CIN) were treated surgically to prevent progression to cancer. In a high-risk country as Denmark......, screening decreased the incidence of cervical cancer from 34 to 11 per 100,000, age-standardized rate (World Standard Population). Screening is, however, also expensive; Denmark (population: 5.6 million) undertakes close to half a million tests per year, and has 6-8 CIN-treated women for each prevented...... cancer case. The discovery of human papillomavirus (HPV) as the cause of cervical cancer dramatically changed perspectives for disease control. Screening with HPV testing was launched around 1990, and preventive HPV vaccination was licensed in 2006. Long-term randomized controlled trials (RCT...

  2. Cervical Cancer

    Science.gov (United States)

    ... to see your doctor. www.cdc.gov/cancer/knowledge 1-800-CDC-INFO Are there tests that can prevent cervical cancer or find it early? There are two tests that can either help prevent cervical cancer or find it early: • The Pap test (or Pap smear)looks for precancers, cell changes, on the cervix ...

  3. Influência da adequabilidade da amostra sobre a detecção das lesões precursoras do câncer cervical Influence of adequacy of the sample on detection of the precursor lesions of the cervical cancer

    Directory of Open Access Journals (Sweden)

    Rita Goreti Amaral

    2008-11-01

    Full Text Available OBJETIVO: avaliar se a adequabilidade da amostra influencia na detecção das lesões precursoras do câncer do colo do útero. MÉTODOS: este foi um estudo de corte transversal, realizado no período de Janeiro de 2004 a Dezembro de 2005. Foram incluídos 10.951 resultados de exames citopatológicos cervicais, tendo como base usuárias do Sistema Único de Saúde de Goiânia, Goiás. Essas mulheres procuraram, espontaneamente, os serviços do Programa Saúde da Família ou Unidades Básicas de Saúde. A coleta foi feita por médicos e enfermeiros por meio da técnica convencional para rastreamento de câncer do colo do útero. Os esfregaços analisados foram classificados de acordo com o Sistema Bethesda, sendo a adequabilidade da amostra definida durante o escrutínio de rotina e categorizada como: satisfatória; satisfatória, porém apresentando fatores que prejudicam parcialmente a análise; e insatisfatória. Os resultados obtidos foram armazenados no programa Epi-Info 3.3.2. Para a comparação entre os resultados alterados e a adequabilidade da amostra dos esfregaços citopatológicos utilizou-se o teste do χ2. Foram consideradas significantes as diferenças em que a probabilidade de rejeição da hipótese de nulidade foi menor que 5% (pPURPOSE: to evaluate whether the sample adequacy influences the detection of precursor cervical cancer lesions. METHODS: a transversal study from January 2004 to December 2005. A number of 10,951 results of cervical cytotopathological exams from users of the National Health System (Sistema Único de Saúde, SUS in Goiânia, Goiás , Brazil, was studied. These women had spontaneously looked for the services from the Family Health Program or from the Basic Units of Health. Samples were collected by medical doctors and nurses, through the conventional technique to detect cervical cancer. The analyzed smears were classified by the Bethesda System, the sample adequacy being defined along the routine

  4. 宫颈 LCT结合阴道镜及宫颈活检对宫颈上皮内瘤变和宫颈癌患者的早期诊断价值研究%Application Value of the LCT Combined with Tissue Biopsy in Early Screening for Cervical Epithelial Lesions and Cervical Cancer

    Institute of Scientific and Technical Information of China (English)

    洪恩

    2014-01-01

    目的:探讨宫颈液基细胞学检查( liquid-based cytological test ,LCT)结合阴道镜及宫颈活检对宫颈上皮内瘤变和宫颈癌患者的早期诊断价值。方法回顾性分析250例宫颈LCT阳性的病例,对其进行宫颈活检。比较细胞学与组织学结果,并研究发病率与年龄的关系。结果在所有LCT阳性病例中,ASC-US 142例(在阳性病例中占56.8%), AGC 为3例(1.2%),ASC-H 24例(9.6%),LSIL 82例(54.4%),HSIL为26例(10.4%),SCC 1例(0.4%);宫颈活检结果中,炎性反应66例(26.4%),挖空细胞25例(10.0%),CINⅠ级54例(21.6%),CINⅡ级59例(23.6%),CIN Ⅲ级28例(11.2%),鳞癌16例(6.4%),腺癌2例(0.8%),以组织学结果验证细胞学结果,符合率分别为 ASC-US (100.0%),ASC-H(92.3%),LSIL(63.2%),HSIL(72.9%),SCC(100.0%);并且宫颈病变多见于30~50岁年龄段。结论宫颈LCT 具有较高的准确性,是筛查宫颈上皮性病变的重要手段,结合阴道镜及宫颈活检可使宫颈上皮内瘤变和宫颈癌患者得到早期诊断和早期治疗。%Objective To explore the application value of the LCT combined with tissue biopsy in early screening for cervical epithelial lesions and cervical cancer .Methods 50 cases of abnormal cytology received cervical LCT inspection were retrospectively analyzed and were treated with biopsy inspection .The cytology and histology results were compared ,and the rela-tionship of lesion and age was analyzed .Results Among those abnormal cytology,the ASC-US was 142 cases (56.8%),AGC was 3 cases(1.2%),ASC-H was 24 cases (9.6%),LSIL was 82 cases (54.4%),HSIL was 26 cases (10.4%),and SCC was 1 cases (0.4%).Among the 250 cases of biopsy,inflammation reaction were 66 cases (26.4%),koilocyte 25 cases (10.0%), CINⅠ54 cases (21.6%),CINⅡ59 cases (23.6%),CINⅢ28 cases

  5. Performance of recycling abrasives in rock cutting by abrasive water jet

    Institute of Scientific and Technical Information of China (English)

    Gokhan Aydin

    2015-01-01

    Rock cutting performance of recycling abrasives was investigated in terms of cutting depth, kerf width, kerf taper angle and surface roughness. Gravity separation technique was employed to separate the abrasives and the rock particles. The recycling abrasive particles were then dried and sieved for determination of their disintegration behaviors. Before each cutting with recycling abrasives, the abrasive particles less than 106mm were screened out. It is revealed that a considerable amount of used abrasives can be effectively reused in the rock cutting. The reusabilities of abrasives are determined as 81.77%, 57.50%, 34.37%and 17.72%after the first, second, third and fourth cuttings, respectively. Additionally, it is determined that recycling must be restricted three times due to the excessive disintegration of abrasives with further recycling. Moreover, it is concluded that cutting depth, kerf width and surface roughness decreases with recycling. No clear trend is found between the kerf taper angle and recycling. Particle size distribution is determined as an important parameter for improving the cutting performance of recycling abrasives.

  6. The measurement of abrasive particles velocities in the process of abrasive water jet generation

    Science.gov (United States)

    Zeleňák, Michal; Foldyna, Josef; Říha, Zdeněk

    2014-08-01

    An optimization of the design of the abrasive cutting head using the numerical simulation requires gathering as much information about processes occurring in the cutting head as possible. Detailed knowledge of velocities of abrasive particles in the process of abrasive water jet generation is vital for the verification of the numerical model. A method of measurement of abrasive particles at the exit of focusing tube using the FPIV technique was proposed and preliminary tests are described in the paper. Results of analysis of measured velocity fields are presented in the paper.

  7. Impact-abrasion and abrasion of WC-Co: wear mechanisms in severe environments

    Energy Technology Data Exchange (ETDEWEB)

    Hawk, Jeffrey A.; Wilson, Rick D.; Osara, K. (Outokumpu Research Oy)

    2003-10-01

    Hard and super-hard materials have very good abrasive wear resistance. However, in many severe wear environments that make use of these materials, impact is a significant component of that environment. Consequently, the behavior of many of these hard materials in impact-wear conditions need to be understood with respect to the mechanisms of material removal such small scale fracture and subsequent crack growth in the carbide. This study details the behavior of several ?hard? materials in abrasion and impact-abrasion focusing on the mechanisms of material removal due to impact and abrasion.

  8. The clinical significance of TCT joint the high-risk HPV-DNA detection in cervical lesions screening%液基细胞学与高危型HPV-DNA联合检测在宫颈病变筛查中的意义

    Institute of Scientific and Technical Information of China (English)

    喻垚; 郭变琴; 罗光丽; 赖年钰

    2015-01-01

    Objective To study the clinical significance of TCT and the high-risk HPV-DNA detection in cer-vical lesions screening .Methods There were 386 cases of cervical cancer ,555 cases of clinical cervicitis ,269 cases of CINⅠ ,133 cases of CINⅡ /Ⅲ ,all have been confirmed by histopathological diagnosis .We detected the cytology le-sions through Thinprep cytology test (TCT ) ,and detected the expression of high-risk HPV-DNA through second-generation hybrid capture Ⅱ(hybrid captme ,HC Ⅱ) .Results The positive expression rates of high-risk HPV-DNA in cervicitis ,CINⅠ ,CINⅡ /Ⅲ ,cervical cancer w ere 26 .5% ,48 .7% ,54 .9% ,72 .0% ,and there w ere statistically sig-nificance in the four groups (P<0 .01) .In screening CINⅠ or above ,sensitivity ,specificity ,PPV and NPV of HR-HPV detection combined with cytology were 80 .2% ,88 .5% ,86 .7% ,81 .3% ,and higher than the separate detec-tion .Conclusion Infection rate of HR-HPV is ascending with serious degree of cervical lesion .HR-HPV detection by HC-Ⅱ is an important method in screening cervical lesion .Combined TCT and HR-HPV test will improve the detec-tion rate of cervical lesions;it is an ideal method to screening cervical cancer and prevention .%目的 探讨薄层液基细胞学(TCT)与高危型人乳头状瘤病毒(HR-HPV) DNA检测在宫颈病变筛查中的临床意义.方法 2012年1月至2014年1月该院就诊的宫颈病变患者1 343例 ,其中临床已病理确诊的宫颈癌386例 ,宫颈炎555例 ,CINⅠ269例 ,CINⅡ /Ⅲ 133例 ,对所有患者均采用 TCT 法检测细胞病变 ,同时使用第2代杂交捕获法(HC2)检测高危型 HPV-DNA的阳性表达率 ,并比较2种方法的敏感性、特异性、阳性预测值和阴性预测值.结果 高危型 HPV-DNA 在宫颈炎、CIN Ⅰ 、CIN Ⅱ /Ⅲ 和宫颈癌中的阳性率分别为 26 .5% 、48 .7% 、54 .9% 、72 .0% ,4组患者之间比较 ,差异有统计学意义(P<0 .01);TCT与高危型HPV-DNA联合检测其敏感性为80 .2

  9. Third abrasive wear mode: is it possible?

    Directory of Open Access Journals (Sweden)

    Ronaldo Câmara Cozza

    2014-04-01

    Full Text Available The objective of this paper is to propose an initial discussion on the characterization of a third abrasive wear mode. The results obtained in a previous work [1] under different test conditions revealed the occurrence of the superposition of the “rolling” and “grooving” abrasive wear modes. This phenomenon was denoted “micro-rolling abrasion” due to the observation that “rolling abrasion” was found to act on “grooving abrasion”.

  10. Abrasive water jet: a complementary tool

    OpenAIRE

    Duarte, J. P.; Peças, P.; E NUNES; H. Gouveia

    1998-01-01

    The abrasive water jet is a powerful cutting tool, whose main advantages lie in the absence of thermal effects and the capability of cutting highly thick materials. Compared with Laser, the abrasive water jet allows the cutting of a larger range of thicknesses and a wider variety of materials such as: ornamental stones, metals, polymers, composites, wood, glass and ceramics. The application of this technology has suffered an extensive growth, with successful applications in varied industrial ...

  11. Are all left supraclavicular lymphadenopathies Virchow's? A retrospective study of 320 left cervical lymphadenopathy

    OpenAIRE

    Veena Raja; Chinnaiya Subramaniam; Babu Rajendra Prasad; Mari Lingiah Harendra Kumar; Balluru Vasudeva Swaroop Raj

    2016-01-01

    Background: Cervical Lymphadenopathy is one of the commonest and sometimes only clinical finding for a benign and malignant lesion. Fine needle aspiration cytology (FNAC) is a simple, safe, rapid and inexpensive method for establishing the diagnosis of lesions. Metastasis is more common in cervical lymph node and enlarged cervical nodes in an elderly patient must be considered as metastatic until proved otherwise. Methods: Retrospectively, 320 cases of left cervical lymph node FNAC were colle...

  12. Abrasive Blasting Unit (ABU) - 16270

    International Nuclear Information System (INIS)

    NUKEM Technologies was contracted to supply a dry, automated drum belt (tumbling) Abrasive Blasting Unit (ABU) to the Joint Research Centre of the European Commission in Ispra, Italy. The ABU was installed in the centralised radioactive waste management area of the JRC-Ispra site in Italy. The unit is to be employed for the decontamination to clearance levels of slightly contaminated metal components and, where practical, concrete or heavy concrete (density ∼3200 kg/m3) blocks arising from the dismantling of nuclear facilities. The presentation is based on the successful construction and installation of the ABU at the JRC Ispra site. Among the several possibilities of adapting conventional abrasive units to nuclear applications, an automatic tumbling machine was preferred, due to the larger output and (mainly) for the ease of operation, with minimum direct handling of contaminated material by operators, thus satisfying the ALARA principle. Consideration was also given to Belgoprocess' successful experience with a predecessor, similar unit. After adequate size reduction batches of up to about 800 kg of material to be decontaminated are automatically introduced into the blasting chamber. Pieces between 100 mm and 800 mm long, between 100 mm and 500 mm wide and between 5 mm and 300 mm high can be effectively treated in the unit, the maximum weight of a single piece being limited to 100 kg. Short lengths of pipe may be included; the final dimensions of pipe to be decontaminated will be established during the nuclear commissioning tests. Other components with hard-to-reach surfaces may also be included. The content of the chamber is tumbled by two bladed drums, while sharp steel grit is sprayed onto the contaminated components, thus removing the surface layer including any contamination. From experience, 30 minutes of treatment is sufficient to remove contamination to levels below expected clearance levels for most materials. The decontaminated components are removed

  13. Cervical spondylolysis in child with four levels of simultaneous involvement: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Gang Deuk; Kim, Hye Won; Jang, Sung Jo; Oh, Jung Taek [Wonkwang University School of Medicine, Gunsan (Korea, Republic of)

    2006-12-15

    Cervical spondylolysis is a rare condition, and less than 100 cases have been reported in the world literature. Cervical spondylolysis is defined as a well corticated defect in the posterior element of a cervical vertebra. Although the etiology of cervical spondylolysis is unknown, its association with dysplastic changes and spina bifida occulta suggest that the lesion is congenital. Here, we describe the radiographs and CT images of cervical spondylolysis involving four levels in a 9 year old boy.

  14. Cervical spondylolysis in child with four levels of simultaneous involvement: a case report

    International Nuclear Information System (INIS)

    Cervical spondylolysis is a rare condition, and less than 100 cases have been reported in the world literature. Cervical spondylolysis is defined as a well corticated defect in the posterior element of a cervical vertebra. Although the etiology of cervical spondylolysis is unknown, its association with dysplastic changes and spina bifida occulta suggest that the lesion is congenital. Here, we describe the radiographs and CT images of cervical spondylolysis involving four levels in a 9 year old boy

  15. Determination of vibration frequency depending on abrasive mass flow rate during abrasive water jet cutting

    Czech Academy of Sciences Publication Activity Database

    Hreha, P.; Radvanská, A.; Hloch, Sergej; Peržel, V.; Krolczyk, G.; Monková, K.

    2014-01-01

    Roč. 77, 1-4 (2014), s. 763-774. ISSN 0268-3768 Institutional support: RVO:68145535 Keywords : Abrasive water jet * Abrasive mass flow rate * Vibration Subject RIV: JQ - Machines ; Tools Impact factor: 1.458, year: 2014 http://link.springer.com/article/10.1007%2Fs00170-014-6497-9#page-1

  16. Cervical spondylosis

    Science.gov (United States)

    ... Past neck injury (often several years before) Past spine surgery Ruptured or slipped disk Severe arthritis Small fractures ... Kshettry VR. Cervical spondylosis. In: Benzel EC, ed. Spine Surgery . 3rd ed. Philadelphia, PA: Elsevier Saunders; 2012:chap ...

  17. Cervical Cancer

    Science.gov (United States)

    ... 162 KB) This information in Spanish (en español) Female reproductive system Select image to view larger Related ... D., FACS, Captain, U.S. Public Health Service Medical Director, National Breast and Cervical Cancer Early Detection Program, ...

  18. Cervical Stenosis

    Science.gov (United States)

    ... Accumulation of pus in the uterus is called pyometra. Symptoms Before menopause, cervical stenosis may cause menstrual ... present but not cause symptoms. A hematometra or pyometra can cause pain or cause the uterus to ...

  19. Cervical metastatic glioblastoma multiforme

    International Nuclear Information System (INIS)

    Glioblastoma multiforme (GBM) is the most common and most malignant primary brain tumour in adults. In spite of the hostile nature of glioblastoma multiforme (GBM), extracranial spread is not a common event. With improving management choices and survival times, reports of extracranial occurrence of GBM have increased. Most commonly these metastases are to the lungs, lymph nodes, neck, skull, scalp, liver, and bones; may be evident on routine follow-up images of the original lesion. Head and neck metastasis of GBM can be debilitating. We present a case of cervical metastasis of GBM and discuss possible mechanisms of extraneural spread of this tumour. (author)

  20. General Information about Cervical Cancer

    Science.gov (United States)

    ... Research Cervical Cancer Treatment (PDQ®)–Patient Version General Information About Cervical Cancer Key Points Cervical cancer is ... the NCI website . Cervical Cancer During Pregnancy General Information About Cervical Cancer During Pregnancy Treatment of cervical ...

  1. An investigation into magnetic electrolytic abrasive turning

    International Nuclear Information System (INIS)

    The magnetic electrolytic abrasive turning (MEAT) process as a non-traditional machining is used to obtain surface finishing like mirror. MEAT provides one of the best alternatives for producing complex shapes with good finish in advanced materials used in aircraft and aerospace industries. The improvement of machining accuracy of MEAT continues to be a major challenge for modern industry. MEAT is a hybrid machining which combines two or more processes to remove material. The present research focuses on the development of precision electrochemical turning (ECT) under the effects of magnetic field and abrasives. The effect of magnetic flux density, electrochemical conditions and abrasive parameters on finishing efficiency and surface roughness are investigated. An empirical relationship is deduced

  2. An investigation into magnetic electrolytic abrasive turning

    Science.gov (United States)

    Mahdy, M. A. M.; Ismaeial, A. L.; Aly, F. F.

    2013-07-01

    The magnetic electrolytic abrasive turning (MEAT) process as a non-traditional machining is used to obtain surface finishing like mirror. MEAT provides one of the best alternatives for producing complex shapes with good finish in advanced materials used in aircraft and aerospace industries. The improvement of machining accuracy of MEAT continues to be a major challenge for modern industry. MEAT is a hybrid machining which combines two or more processes to remove material. The present research focuses on the development of precision electrochemical turning (ECT) under the effects of magnetic field and abrasives. The effect of magnetic flux density, electrochemical conditions and abrasive parameters on finishing efficiency and surface roughness are investigated. An empirical relationship is deduced.

  3. Geometrical and physical models of abrasion

    CERN Document Server

    Domokos, G

    2013-01-01

    We extend the geometrical theory presented in [5] for collisional and frictional particle abrasion to include an independent physical equation for the evolution of mass and volume. We introduce volume weight functions as multipliers of the geometric equations and use these mutipliers to enforce physical volume evolution in the unified equations. The latter predict, in accordance with Sternberg's Law, exponential decay for volume evolution. We describe both the PDE versions, which are generalisations of Bloore's equations and their heuristic ODE approximations, called the box equations. The latter are suitable for tracking the collective abrasion of large particle populations. The mutual abrasion of identical particles, called the self-dual ows, play a key role in explaining geological scenarios. We give stability criteria for the self-dual ows in terms of the parameters of the physical volume evolution models and show that under reasonable assumptions these criteria can be met by physical systems. We also stu...

  4. Basics of cutting and abrasive processes

    CERN Document Server

    Toenshoff, Hans Kurt

    2013-01-01

    Manufacturing is the basic industrial activity generating real value. Cutting and abrasive technologies are the backbone of precision production in machine, automotive and aircraft building as well as of production of consumer goods. We present the knowledge of modern manufacturing in these technologies on the basis of scientific research. The theory of cutting and abrasive processes and the knowledge about their application in industrial practice are a prerequisite for the studies of manufacturing science and an important part of the curriculum of the master study in German mechanical engineering. The basis of this book is our lecture “Basics of cutting and abrasive processes” (4 semester hours/3 credit hours) at the Leibniz University Hannover, which we offer to the diploma and master students specializing in manufacturing science.

  5. Abrasive water jet: a complementary tool

    International Nuclear Information System (INIS)

    The abrasive water jet is a powerful cutting tool, whose main advantages lie in the absence of thermal effects and the capability of cutting highly thick materials. Compared with Laser, the abrasive water jet allows the cutting of a larger range of thicknesses and a wider variety of materials such as: ornamental stones, metals, polymers, composites, wood, glass ceramics. The application of this technology has suffered and extensive growth, with successful applications in varied industrial sectors like the automotive, aerospace, textile, metalworking, ornamental stones, etc. The present communication aims at introducing the abrasive water jet as a complementary tool to laser cutting, presenting its advantages by showing some documented examples of pieces cut for different industries. (Author) 5 refs

  6. Telomerase activity as a biomarker for (pre)neoplastic cervical disease in scrapings and frozen sections from patients with abnormal cervical smear

    NARCIS (Netherlands)

    Wisman, GBA; Hollema, H; de Jong, S; ter Schegget, J; Tjong-A-Hung, SP; Ruiters, MHJ; Krans, M; de Vries, EGE; van der Zee, AGJ

    1998-01-01

    Purpose: To evaluate the diagnostic value of semiquantitative telomerase activity assessment in cervical scrapings together with human papillomavirus (HPV) typing for detection of (pre)neoplastic cervical lesions and to compare telomerase activity in cervical scrapings and frozen specimens from the

  7. Abrasion test of flexible protective materials on hydraulic structures

    Directory of Open Access Journals (Sweden)

    Xin WANG

    2014-01-01

    Full Text Available In this study, several kinds of flexible protective materials sprayed with polyurea elastomers (hereinafter referred to as polyurea elastomer protective material were adopted to meet the abrasion resistance requirement of hydraulic structures, and their abrasion resistances against the water flow with suspended load or bed load were studied systematically through tests. Natural basalt stones were adopted as the abrasive for simulation of the abrasion effect of the water flow with bed load, and test results indicate that the basalt stone is suitable for use in the abrasion resistance test of the flexible protective material. The wear process of the polyurea elastomer protective material is stable, and the wear loss is linear with the time of abrasion. If the wear thickness is regarded as the abrasion resistance evaluation factor, the abrasion resistance of the 351 pure polyurea is about twice those of pure polyurea with a high level of hardness and aliphatic polyurea, and over five times that of high-performance abrasion-resistant concrete under the abrasion of the water flow with suspended load. It is also about 50 times that of high-performance abrasion-resistant concrete under the abrasion of the water flow with bed load. Overall, the abrasion resistance of pure polyurea presented a decreasing trend with increasing hardness. Pure polyurea with a Shore hardness of D30 has the best abrasion resistance, which is 60 to 70 times that of high-performance abrasion-resistant concrete under the abrasion of the water flow with bed load, and has been recommended, among the five kinds of pure polyurea materials with different hardness, in anti-abrasion protection of hydraulic structures.

  8. Abrasion test of flexible protective materials on hydraulic structures

    Institute of Scientific and Technical Information of China (English)

    Xin WANG; Shao-ze LUO; Guang-sheng LIU; Lu-chen ZHANG; Yong WANG

    2014-01-01

    In this study, several kinds of flexible protective materials sprayed with polyurea elastomers (hereinafter referred to as polyurea elastomer protective material) were adopted to meet the abrasion resistance requirement of hydraulic structures, and their abrasion resistances against the water flow with suspended load or bed load were studied systematically through tests. Natural basalt stones were adopted as the abrasive for simulation of the abrasion effect of the water flow with bed load, and test results indicate that the basalt stone is suitable for use in the abrasion resistance test of the flexible protective material. The wear process of the polyurea elastomer protective material is stable, and the wear loss is linear with the time of abrasion. If the wear thickness is regarded as the abrasion resistance evaluation factor, the abrasion resistance of the 351 pure polyurea is about twice those of pure polyurea with a high level of hardness and aliphatic polyurea, and over five times that of high-performance abrasion-resistant concrete under the abrasion of the water flow with suspended load. It is also about 50 times that of high-performance abrasion-resistant concrete under the abrasion of the water flow with bed load. Overall, the abrasion resistance of pure polyurea presented a decreasing trend with increasing hardness. Pure polyurea with a Shore hardness of D30 has the best abrasion resistance, which is 60 to 70 times that of high-performance abrasion-resistant concrete under the abrasion of the water flow with bed load, and has been recommended, among the five kinds of pure polyurea materials with different hardness, in anti-abrasion protection of hydraulic structures.

  9. Effect of Cervical Lessions on the Tooth FEM Study

    Directory of Open Access Journals (Sweden)

    Gabriela Bereşescu

    2010-12-01

    Full Text Available The approach used until recently concerning the phenomena of dental abfraction points to the conclusion that the cervical area of the tooth, were this type of lesion usually occur, concentrates the stress resulted from the action of the forces applied on various areas on the crown. Moreover, any lesion in the cervical area facilitates the possibility of its advance into the tooth, ultimately fracturing it. Our paper presents a FEM (finite element method study on the results of a mechanical analysis of the phenomena involving the tooth damaged by cervical lesions.

  10. Mycobacterium ulcerans fails to infect through skin abrasions in a guinea pig infection model: implications for transmission.

    Science.gov (United States)

    Williamson, Heather R; Mosi, Lydia; Donnell, Robert; Aqqad, Maha; Merritt, Richard W; Small, Pamela L C

    2014-04-01

    Transmission of M. ulcerans, the etiological agent of Buruli ulcer, from the environment to humans remains an enigma despite decades of research. Major transmission hypotheses propose 1) that M. ulcerans is acquired through an insect bite or 2) that bacteria enter an existing wound through exposure to a contaminated environment. In studies reported here, a guinea pig infection model was developed to determine whether Buruli ulcer could be produced through passive inoculation of M. ulcerans onto a superficial abrasion. The choice of an abrasion model was based on the fact that most bacterial pathogens infecting the skin are able to infect an open lesion, and that abrasions are extremely common in children. Our studies show that after a 90d infection period, an ulcer was present at intra-dermal injection sites of all seven animals infected, whereas topical application of M. ulcerans failed to establish an infection. Mycobacterium ulcerans was cultured from all injection sites whereas infected abrasion sites healed and were culture negative. A 14d experiment was conducted to determine how long organisms persisted after inoculation. Mycobacterium ulcerans was isolated from abrasions at one hour and 24 hours post infection, but cultures from later time points were negative. Abrasion sites were qPCR positive up to seven days post infection, but negative at later timepoints. In contrast, M. ulcerans DNA was detected at intra-dermal injection sites throughout the study. M. ulcerans was cultured from injection sites at each time point. These results suggest that injection of M. ulcerans into the skin greatly facilitates infection and lends support for the role of an invertebrate vector or other route of entry such as a puncture wound or deep laceration where bacteria would be contained within the lesion. Infection through passive inoculation into an existing abrasion appears a less likely route of entry. PMID:24722416

  11. Cervical thoracic duct cyst: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sang Hyun; Han, Jong Kyu; Lee, Chi Kyu; Jo, Sung Sik; Kim, Hyung Hwan; Bae, Won Kyung; Kim, Il Yung [Chunan Hospital Soonchunhyang University, Chunan (Korea, Republic of)

    2007-06-15

    Thoracic duct cysts are uncommon lesions that most commonly occur in the abdominal and thoracic portion of the thoracic duct: the cervical portion is the rarest location. The main causes of thoracic duct cyst are surgical injuries such as neck dissection and blunt trauma. We report here on a rare case of spontaneous cervical thoracic duct cyst that was noted on ultrasonography and CT. The thoracic duct cyst was confirmed by fine needle aspiration and it was treated by sclerotherapy.

  12. Immunosuppression and risk of cervical cancer

    DEFF Research Database (Denmark)

    Dugué, Pierre-Antoine; Rebolj, Matejka; Garred, Peter;

    2013-01-01

    A markedly increased risk of cervical cancer is known in women immunosuppressed due to AIDS or therapy following organ transplantation. The aim of this review is to determine the association between other conditions affecting the immune system and the risk of cervical cancer. Patients with end......-stage renal disease seem to be at an increased risk of cervical cancer. A higher risk of cervical precancerous lesions was found in patients with some autoimmune diseases; particularly if treated with immunosuppressants. Among behavioral factors weakening the immune system, smoking appeared to strongly...... increase the risk of cervical cancer, while poor diet only moderately increased the risk. It is difficult to determine whether sexually transmitted infections other than human papillomavirus infection are independent risk factors. Identifying those groups of women likely to fail in clearing persistent...

  13. Recent progress of abrasion-resistant materials: learning from nature.

    Science.gov (United States)

    Meng, Jingxin; Zhang, Pengchao; Wang, Shutao

    2016-01-21

    Abrasion-resistant materials have attracted great attention for their broad applications in industry, biomedicine and military. However, the development of abrasion-resistant materials that have with unique features such as being lightweight and flexible remains a great challenge in order to satisfy unmet demands. The outstanding performance of natural abrasion-resistant materials motivates the development of new bio-inspired abrasion-resistant materials. This review summarizes the recent progress in the investigation of natural abrasion-resistant materials to explore their general design principles (i.e., the correlation between chemical components and structural features). Following natural design principles, several artificial abrasion-resistant materials have shown unique abrasion-resistant properties. The potential challenges in the future and possible solutions for designing bio-inspired abrasion-resistant materials are also briefly discussed. PMID:26335377

  14. The investigation on the cervical lesions in the combined use of cytology and the significance of hu-man papilloma virus detection%探讨子宫颈病变中联合应用细胞学及人类乳头状瘤病毒检测的意义

    Institute of Scientific and Technical Information of China (English)

    刘禄; 杨娜; 杨槐; 蒲泽宴; 刘方久; 张薇珊; 崔丽娟; 罗启翅

    2016-01-01

    目的:研究子宫颈病变诊断中联合细胞学和人类乳头状瘤病毒检测对病理诊断的作用。方法:收集遂宁市中心医院病理科子宫颈活组织检查标本876例,分别进行细胞学检查及人类乳头状瘤病毒检测,采用统计学软件进行数据分析。结果:31~50岁为高危型 HPV 感染高发年龄,分别占26.7%和45.7%。子宫颈鳞状细胞癌在41~50岁年龄组占43.7%。结论:子宫颈脱落细胞学及高危型 HPV 检测在子宫颈癌筛查及诊断中具有重要作用,随着我国经济社会的发展,国家应加大筛查的宣传力度,子宫颈脱落细胞学及高危型 HPV 检测可以明显降低子宫颈癌的发病率。%Objective:To research joint cytological diagnosis of cervical lesions and human papilloma virus detection of pathological diagnosis. Methods:Collection of suining city central hospital,876 cases of cervical biopsy specimens,respectively for cytologic examination and detection of human papilloma virus using statistical software for data analysis. Results:31 to 50 years old in high - risk type HPV infection high - risk age,respectively,26. 7% ,45. 7% . Cervical squamous cell carcinoma (43. 7% )as the highest in group C. Conclusion:Type cervical exfoliated cytology and high - risk HPV detection in cervical cancer screening and diagnosis plays an important role,along with the development of China's economic and social,countries should step up the propaganda screening,cervical exfoliated cytology and high - risk type HPV testing can significantly reduce the incidence of cervical cancer.

  15. Histomorphological Pattern of Cervical Lymphadenopathy

    Directory of Open Access Journals (Sweden)

    Abdul Mannan Sikder

    2013-01-01

    Full Text Available Background: Enlarged palpable cervical lymph nodes as a primary presenting sign are very common and may be due to inflammatory lesions and tumors. Correlation between clinical findings and laboratory data is essential in arriving at a diagnosis. In patients presenting with cervical lymphadenopathy, excision biopsy provides material to establish an early diagnosis. We designed this study in our population for histological evaluation of cervical lymph node biopsies that might be important in the management of these patients. Objective: Histopathological evaluation of different diseases involving the cervical lymph nodes in relation to age and sex of the study population. Materials and Methods: It was a cross sectional study conducted in the department of Pathology, Enam Medical College & Hospital, Savar, Dhaka during the period from January 2006 to December 2010. A total of 107 patients were evaluated for specific cause of cervical lymphadenopathy in relation to age and sex. Lymph node biopsies of all patients of both sexes and all age groups were included in the study. Results: Among the 107 subjects 58 (54.2% were males and 49 (45.8% were females with a male to female ratio of 1.2:1. The age of the patients ranged from 2 to 85 years with a mean age of 32.68 ± 18.01 years. Of the 107 lymph node biopsies, 34 cases (31.8% were reactive lymphadenitis, 41 cases (38.3% were tuberculosis, 2 cases (1.9% were non-caseous granuloma, 6 cases (5.6% were Hodgkin lymphoma, 8 cases (7.5% were non-Hodgkin lymphoma, 12 cases (11.2% were metastatic neoplasm and 4 cases (3.7% were other specific lesions. Conclusion: The commonest cause of cervical lymphadenopathy was tuberculosis, followed by reactive lymphadenitis, lymphoma and metastatic neoplasm.

  16. 21 CFR 872.6030 - Oral cavity abrasive polishing agent.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Oral cavity abrasive polishing agent. 872.6030... (CONTINUED) MEDICAL DEVICES DENTAL DEVICES Miscellaneous Devices § 872.6030 Oral cavity abrasive polishing agent. (a) Identification. An oral cavity abrasive polishing agent is a device in paste or powder...

  17. 9 CFR 311.14 - Abrasions, bruises, abscesses, pus, etc.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Abrasions, bruises, abscesses, pus, etc. 311.14 Section 311.14 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT... PARTS § 311.14 Abrasions, bruises, abscesses, pus, etc. All slight, well-limited abrasions on the...

  18. PHAEOHYPHOMYCOSIS: CUTANEOUS, SUBCUTANEOUS, NASOPHARYNGEAL LESIONS

    Directory of Open Access Journals (Sweden)

    M. Rasoolinejad

    1999-06-01

    Full Text Available Phaeohyphomycosis is an amalgam of clinical diseases caused by a wide variety of dematiaceous fungi. We are reporting on a 16 year-old patient from Amol with subcutaneous cervical nodes and nasopharyngeal lesions of phaeohypho"nmycosis that were confirmed by pathological examination, direct smear, and culture. After treatment with an oral triazole (Itraconazole for 4 months, all nodes and lesions disappeared and treatment was stopped A new lesion appeared on his chest wall 8 months, therapy with itraconazole was restarted and commuted for a long time.

  19. Pediatric Upper Cervical Spine Giant Cell Tumor: Case Report

    OpenAIRE

    Alfawareh, Mohammad D.; Shah, Irfanullah D.; Orief, Tamer I.; Halawani, Mohammad M.; Attia, Walid I.; Almusrea, Khaled N.

    2014-01-01

    Study Design Case report. Objective The purpose of this work is to report the case of a giant cell tumor involving the second cervical vertebra in a pediatric patient. Surgical management included a combined posterior and anterior cervical approach. There has been no recurrence in 2 years of follow-up. Case Report A 13-year-old girl presented with scoliosis with incidentally lytic lesion involving the second cervical vertebra. The radiologic investigations and biopsy result indicated a giant ...

  20. One-year clinical evaluation of tooth-colored materials in non-carious cervical lesions Avaliação clínica de restaurações de lesões cervicais não cariosas

    Directory of Open Access Journals (Sweden)

    Sérgio Lima Santiago

    2003-09-01

    Full Text Available The purpose of this study was to assess the clinical performance of bonded composite (Excite/Tetric Ceram - Vivadent versus a resin-modified glass ionomer cement (Vitremer - 3M for restoring non-carious cervical lesions. A total of 70 restorations (thirty-five per material were placed in 30 patients, 18-50 aged, by one operator. Rubber dam was employed in all cases, lesions were pumiced, enamel margins were not beveled, and no mechanical retention was placed. The restorations were directly assessed by two independent evaluators using modified-USPHS criteria for six clinical categories. The ratings for clinical acceptability restorations (alfa plus bravo were as follows (Tetric Ceram/Vitremer: retention (86%/100%, marginal integrity (100%/100%, marginal discoloration (100%/100%, wear (97%/100%, postoperative sensitivity (100%/100% and recurrent caries (100%/100%. Statistical analysis was completed with Fisher's exact or Pearson Chi-square tests at a significance level of 5% (PAvaliou-se o desempenho clínico de um sistema restaurador adesivo (Excite - Tetric Ceram/ Vivadent e do cimento de ionômero de vidro modificado por resina (Vitremer/ 3M na restauração de lesões cervicais não cariosas por meio do sistema de avaliação do USPHS modificado. Um total de setenta restaurações, trinta e cinco por material, foi realizado por um único operador em trinta pacientes voluntários com idades de 18 a 50 anos. Previamente à execução das restaurações, foi realizada uma profilaxia com pedra-pomes e água a fim de remover quaisquer resíduos. As lesões cervicais não foram submetidas a qualquer tipo de preparo cavitário, sendo restauradas sob isolamento absoluto e de acordo com as instruções do fabricante. Todas as restaurações foram avaliadas pelo método direto por dois examinadores usando os critérios de retenção (R, integridade marginal (IM, descoloração marginal (DM, desgaste (D, sensibilidade pós-operatória (S e incidência de

  1. Langerhans cell histiocytosis of the cervical spine: case report of an unusual location

    International Nuclear Information System (INIS)

    An unusual location for Langerhans cell histiocytosis of the cervical spine is presented. The osteolytic lesion, instead of being located in the vertebral body, was visualised in the left lateral mass of the fifth cervical vertebra, extending into the vertebral body and through the interapophyseal joint into the lateral mass of the fourth cervical vertebra. (orig.)

  2. Langerhans cell histiocytosis of the cervical spine: case report of an unusual location

    Energy Technology Data Exchange (ETDEWEB)

    Geusens, E.; Brys, P.; Ghekiere, J.; Baert, A.L. [Department of Radiology, University Hospital Gasthuisberg KU Leuven (Belgium); Samson, I. [Department of Orthopedic Surgery, University Hospitals, Leuven (Belgium); Sciot, R. [Department of Pathology II, University Hospitals, Leuven (Belgium); Brock, P. [Department of Pediatrics, University Hospitals, Leuven (Belgium)

    1998-09-01

    An unusual location for Langerhans cell histiocytosis of the cervical spine is presented. The osteolytic lesion, instead of being located in the vertebral body, was visualised in the left lateral mass of the fifth cervical vertebra, extending into the vertebral body and through the interapophyseal joint into the lateral mass of the fourth cervical vertebra. (orig.) With 3 figs., 7 refs.

  3. Langerhans cell histiocytosis of the cervical spine: case report of an unusual location.

    Science.gov (United States)

    Geusens, E; Brys, P; Ghekiere, J; Samson, I; Sciot, R; Brock, P; Baert, A L

    1998-01-01

    An unusual location for Langerhans cell histiocytosis of the cervical spine is presented. The osteolytic lesion, instead of being located in the vertebral body, was visualised in the left lateral mass of the fifth cervical vertebra, extending into the vertebral body and through the interapophyseal joint into the lateral mass of the fourth cervical vertebra. PMID:9724427

  4. Evalution of gene expression of the human telomerase gene in the screating of cervical lesions%hTERC基因表达在宫颈病变筛查中的意义

    Institute of Scientific and Technical Information of China (English)

    周波; 李婷; 周晨; 陈忠东; 谢宛玉

    2011-01-01

    Objective: To investigate the human telomerase RNA (hTERC) gene in the screating of cervical lesions. Methods; Hie expression of hTERC gene of cervix cytologic samples were detectded by using fluorescence in situ hybridization ( FISH) . According to histology biopsy 115 Pap smears were divided into cervinl intraepithelial neoplasin ( CIN, n =69), squamous carcinomal of the cervix (SCC, n=26) . Normnl (n =20) . Results: The positive rate of hTERC gene in CIN I , CIN Ⅱ, CIN Ⅲand SCC were respectively 22. 00% , 75. 00% , 100.00%and 100. 00% (P <0.05) . hTERC gene copy numbers in CINIⅡ/CINⅢ/SCC were significantly higher than that in CIN I. The number of abnormal cells were increased in gene amplification for hTERC , CIN I was 6.50% , CINⅡ was 25. 50% , CIN Ⅲ was 30. 60% , SCC was 50. 80% (P <0.05) . The abnormal hTERC signal types of 2:3 founded in CIN I was 60.00% , in CIN Ⅱ, CIN Ⅲ and SCC were 47.10% , 45.18% and 36.44% respectively. In SCC, the abnormal hTERC signal types were 4:4 and 5 : 5 mainly. Conclusion: The increase of hTERC expression in the invasive CIN and SCC, the copy numbers are associated with the severity of cytologic and histologic findings. Therefore can as a screening detection index of biometrical genetics for progress of cervical anterior lesions.%目的:探讨人端粒酶RNA (hTERC)基因在宫颈病变筛查中的临床意义.方法:收集2008年1月~11月南华大学第一附属医院115例妇女宫颈脱落细胞标本,病理学检查确诊CIN患者69例,宫颈鳞癌(SCC)患者26例,正常细胞学妇女20例.用荧光原位杂交(FISH)方法检测脱落细胞hTERC基因的表达.结果:①hTERC基因在CIN Ⅰ、CINⅡ、CINⅢ及SCC患者宫颈脱落细胞中的阳性表达率分别是22.00%、75.00%、100.00%和100.00%.CIN Ⅰ、CINⅡ、CINⅢ和SCC组与正常组比较,hTERC基因阳性率差异有统计学意义(P<0.05).其中CIN Ⅰ与CINⅡ、CINⅢ比较,CIN Ⅰ与SCC比较差异有统计学意义(P<0

  5. Gene promoter methylation patterns throughout the process of cervical carcinogenesis

    NARCIS (Netherlands)

    Yang, Nan; Nijhuis, Esther R.; Volders, Haukeline H.; Eijsink, Jasper J. H.; Lendvai, Agnes; Zhang, Bo; Hollema, Harry; Schuuring, Ed; Wisman, G. Bea A.; van der Zee, Ate G. J.

    2010-01-01

    Objectives: To determine methylation status of nine genes, previously described to be frequently methylated in cervical cancer, in squamous intraepithelial lesions (SIL). Methods: QMSP was performed in normal cervix, low-grade ( L) SIL, high-grade (H) SIL, adenocarcinomas and squamous cell cervical

  6. Generalized cervical root resorption associated with periodontal disease

    NARCIS (Netherlands)

    Beertsen, W; Piscaer, M; Van Winkelhoff, AJ; Everts, P. A. M.

    2001-01-01

    Background and description of case: The etiology and pathogenesis of generalized cervical root resorptions is not well understood. In the present report, a case of severe cervical root resorption involving 24 anterior and posterior teeth is presented. The lesions developed within a period of 2 years

  7. Usage of abrasion-resistant materials in agriculture

    Directory of Open Access Journals (Sweden)

    J Votava

    2014-06-01

    Full Text Available Agricultural soil-processing machines are subject to an extensive abrasive wear. This paper analyses technical materials and their fitness to exchangeable parts of plough bottoms, such as edge-tools and whole plough cutting edges. There were tested abrasion-resistant steels with different microstructures: austenite, martensite-bainite, and carbide. Steel with the pearlite-ferrite structure was used as an etalon. Abrasion resistance tests were processed in compliance with the norm CSN 01 5084, which is a test of abrasion wear on abrasive cloth.

  8. Gingival abrasion and plaque removal with manual versus electric toothbrushing.

    Science.gov (United States)

    Niemi, M L; Ainamo, J; Etemadzadeh, H

    1986-08-01

    A clinical trial was designed to test the relative numbers of gingival lesions caused during standardized brushing of the teeth of 22 volunteer dental nurse students with a manual soft multitufted, a manual soft V-shaped, and an electric toothbrush. First, the left or the right side of the jaws of each subject was brushed by a dental hygienist using the manual V-shaped or the electric brush, and the other side using the manual multitufted brush. At the 2nd brushing 1 week later, the same hygienist used the multitufted brush for brushing the side contralateral to the one in which it was used the 1st week and the V-shaped manual brush instead of the electric and vice versa. After each brushing, the number of new gingival lesions was recorded and the cleansing effect evaluated by assessment of the amount of remaining plaque. This examiner was unaware of the type of brush used. The V-shaped manual toothbrush was found to have caused more gingival abrasion than the electric toothbrush (P less than 0.005) and a similar difference was found between the multitufted manual and the electric toothbrush (P less than 0.05). There was no clinically significant difference between the plaque removing effects of the 3 brushes tested. PMID:3463575

  9. Implications of tyrosine phosphoproteomics in cervical carcinogenesis

    Directory of Open Access Journals (Sweden)

    DeFord James

    2008-01-01

    Full Text Available Abstract Background Worldwide cervical cancer remains a leading cause of mortality from gynecologic malignancies. The link between cervical cancer and persistent infection with HPV has been established. At a molecular level little is known about the transition from the precancerous state to invasive cancer. To elucidate this process, cervical biopsies from human specimens were obtained from precancerous state to stage III disease. Methods Cervical biopsies were obtained from patients with a diagnosis of cervical cancer undergoing definitive surgery or staging operation. Biopsies were obtained from patients with precancerous lesions at the time of their excisional procedure. Control samples were obtained from patients undergoing hysterectomy for benign conditions such as fibroids. Samples were subjected to proteomic profiling using two dimensional gel electrophoresis with subsequent trypsin digestion followed by MALDI-TOF protein identification. Candidate proteins were then further studied using western blotting, immunoprecipitation and immunohistochemistry. Results Annexin A1 and DNA-PKcs were found to be differentially expressed. Phosphorylated annexin A1 was up regulated in diseased states in comparison to control and its level was strongly detected in the serum of cervical cancer patients compared to controls. DNA-PKcs was noted to be hyperphosphorylated and fragmented in cancer when compared to controls. By immunohistochemistry annexin A1 was noted in the vascular environment in cancer and certain precancerous samples. Conclusion This study suggests a probable role for protein tyrosine phosphorylation in cervical carcinogenesis. Annexin A1 and DNA-PK cs may have synergistic effects with HPV infection. Precancerous lesions that may progress to cervical cancer may be differentiated from lesions that will not base on similar immunohistochemical profile to invasive squamous cell carcinoma.

  10. Properties, structure and machnining capabilities sintered corundum abrasives

    Directory of Open Access Journals (Sweden)

    Cz.J. Niżankowski

    2010-07-01

    Full Text Available The diversity of sintered corundum abrasives used in both bonded and in the embankment of abrasive tools currently poses substantialproblems for their choice of technology to specific tasks. Therefore performed a comparative study of ownership structures and capacitiesof elected representatives machnining sintered corundum abrasives of different generations, and this is normal sintered alumina,submicrocrystalline alumina sintered and nanocrystalline alumina sintered. Were studied some properties of a set of abrasive particles,physicochemical properties and structural and mechanical and technological properties. The studies used the method of microscopicmeasurement to determine the shape of abrasive particles, the pycnometer to determine the density of abrasive, a spectrometer todetermine the chemical composition of the magnetic analyzer for determining the magnetic fraction, scanning electron microscope toanalysis of abrasive grains and a special position to designate the machining capacity abrasive grains. The results showed a significantincrease in machining capacity sintered corundum abrasives with increasing degree of fragmentation of the crystallites sintered corundum abrasives and distinctive bands in the emerging microchip. The originality of the development provides a comparative summary ofproperties of sintered corundum abrasives of different generations and functions obtained by the author making the change in value indexof machininhcapacity grit from cutting speeds for different generations of sintered corundum.

  11. Liquid Based Cytology and Colposcopy in the Screening of Cervical Cancer and Precancerous Lesions%宫颈液基细胞学及阴道镜在宫颈癌及癌前病变中的筛查作用

    Institute of Scientific and Technical Information of China (English)

    王清; 胡霞

    2015-01-01

    目的:分析液基细胞学和阴道镜在宫颈癌及癌前病变中的筛查作用,评估液基细胞学和阴道镜在宫颈癌及癌前病变筛查中的临床应用价值。方法回顾性分析2013年5月-2014年8月接受宫颈癌筛查的500例女性的临床资料,所有体检者都接受阴道镜检查和液基细胞学检查。结果阴道镜检测假阳性患者有11例,阴道镜检测的特异性为97.39%(412/423),漏诊率为1.00%(5/500);液基细胞学诊断的假阳性患者有15例,由检测结果可知液基细胞学检测宫颈癌的检测特异性为96.45%(408/423),漏诊率为6.40%(32/500)。结论液基细胞学和阴道镜在宫颈癌及癌前病变筛查中具有临床应用价值,阴道镜对宫颈癌及癌前病变的检出率较液基细胞学高。%Objective To study the application value of liquid based cytology and colposcopy in the screening of cervical cancer and precancerous lesions .Methods Retrospective analysis of clinical data of 500 female patients who underwent cervical cancer screening were conducted .All subjects received colposcopy and liquid based cytology .Results Colposcopy results showed that false positive were 11 cases,the specificity of colposcopy was 97.39%(412 /423),the rate of missed diagnosis was 1.00%(5 /500);liquid based cytology diagnosis showed that false positive were 15 cases,specificity was 96.45%(408/423),the rate of missed diagnosis was 6.40%(32 /500).Conclusion Liquid based cytology and colposcopy has clinical application value in the screening of cervical cancer and precancerous lesions ,Colposcopy for cervical cancer and precancerous lesions has higher detec -tion rate compared with liquid based cytology .

  12. Distracted cervical spinal fusion for management of caudal cervical spondylomyelopathy in large-breed dogs

    International Nuclear Information System (INIS)

    Using an autogenous bone graft (obtained from the iliac crest), 4-mm cancellous bone screws, and polymethylmethacrylate, a distracted cervical spinal fusion technique was performed on 10 dogs with myelographic evidence of caudal cervical spondylomyelopathy. All dogs had evidence of dynamic soft tissue spinal cord compression, as indicated by flexion, extension, and traction myelographic views. Of the 10 dogs, 4 previously had undergone surgery by use of ventral slot or cervical disk fenestration techniques, and their neurologic status had deteriorated after the original surgery. Preoperative neurologic status of the 10 dogs included nonambulatory tetraparesis (n = 5), severe ataxia with conscious proprioceptive deficits (n = 2), and mild ambulatory ataxia with conscious proprioceptive deficits (n = 3). Five dogs had signs of various degrees of cervical pain. Clinical improvement was observed in 8 of 10 dogs--either improved neurologic status or elimination of cervical pain. Implant loosening developed in 3 dogs; 2 of them were euthanatized because of lack of neurologic improvement. Radiographic evidence of bony cervical fusion was observed during a 9- to 24-week period in 6 of the 8 surviving dogs. The distracted cervical fusion technique appears to be a valid surgical procedure to manage cervical spondylomyelopathy in those dogs in which the lesions are limited to one cervical intervertebral disk space

  13. Risks of Cervical Cancer Screening

    Science.gov (United States)

    ... Treatment Cervical Cancer Prevention Cervical Cancer Screening Research Cervical Cancer Screening (PDQ®)–Patient Version What is screening? Screening ... These are called diagnostic tests . General Information About Cervical Cancer Key Points Cervical cancer is a disease in ...

  14. Cervical spine CT scan

    Science.gov (United States)

    ... cervical spine; Computed tomography scan of cervical spine; CT scan of cervical spine; Neck CT scan ... Risks of CT scans include: Being exposed to radiation Allergic reaction to contrast dye CT scans expose you to more radiation than ...

  15. Endometrial cancer with cervical extension mimicking dual concordant endometrial and cervical malignancy by F18 FDG PET and MRI

    International Nuclear Information System (INIS)

    A 35 year old woman with endometrial cancer and cervical extension underwent F18 FDG PET CT and MRI studies after resection of a cervical mass presumed to be cervical myoma. The patient underwent cervical myomectomy and the histopathologic report revealed poorly differentiated invasive carcinoma. Cervical cancer was ruled out because the patient had no history of sexual intercourse and was negative for human papilloma virus infection. The patient underwent radical hysterectomy, bilateral salpingo oophorectomy, pelvic and para aortic lymph node dissection, and multiple biopsies. F18 FDG PET CT showed intense FDG uptake along the cervix wall. T2 weighted MRI also revealed a mass lesion with high SI involving the anterior and posterior lips of the uterine cervix. Another area of focal increased uptake above the endometrial lesion in the left pelvic cavity was observed on PET CT and MRI, possibly due to a functioning ovary. PET CT and MRI were interpreted as showing a dual concordant malignant lesion due to separated FDG uptakes and high SI without any connection between the cervical and endometrial lesions. F18 FDG PET CT showed intense FDG uptake along the endometrium. Given the patient's history and the fact that she was not menstruating at the time of imaging, this intense uptake was interpreted as another pathologic lesion, suggesting dual primary lesions. A suspected heterogeneous mass lesion along the endometrium suggesting concordant endometrial cancer was found on MRI. Endometrial cancer with cervical extension is sometimes difficult to differentiate from primary cervical cancer. The final histopathologic report showed poorly differentiated endometrial adenocarcinoma with cervical extension, although the FDG PET CT and MRI findings were suggestive of concordant cervical and endometrial cancer. Although histopathologic confirmation is necessary for final diagnosis, MRI and FDG PET CT studies may aid in the differential diagnosis. A metastatic cervical mass from

  16. Endometrial cancer with cervical extension mimicking dual concordant endometrial and cervical malignancy by F18 FDG PET and MRI

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Seok Nam [Kwandong Univ. College of Medicine, Seoul (Korea, Republic of)

    2012-09-15

    A 35 year old woman with endometrial cancer and cervical extension underwent F18 FDG PET CT and MRI studies after resection of a cervical mass presumed to be cervical myoma. The patient underwent cervical myomectomy and the histopathologic report revealed poorly differentiated invasive carcinoma. Cervical cancer was ruled out because the patient had no history of sexual intercourse and was negative for human papilloma virus infection. The patient underwent radical hysterectomy, bilateral salpingo oophorectomy, pelvic and para aortic lymph node dissection, and multiple biopsies. F18 FDG PET CT showed intense FDG uptake along the cervix wall. T2 weighted MRI also revealed a mass lesion with high SI involving the anterior and posterior lips of the uterine cervix. Another area of focal increased uptake above the endometrial lesion in the left pelvic cavity was observed on PET CT and MRI, possibly due to a functioning ovary. PET CT and MRI were interpreted as showing a dual concordant malignant lesion due to separated FDG uptakes and high SI without any connection between the cervical and endometrial lesions. F18 FDG PET CT showed intense FDG uptake along the endometrium. Given the patient's history and the fact that she was not menstruating at the time of imaging, this intense uptake was interpreted as another pathologic lesion, suggesting dual primary lesions. A suspected heterogeneous mass lesion along the endometrium suggesting concordant endometrial cancer was found on MRI. Endometrial cancer with cervical extension is sometimes difficult to differentiate from primary cervical cancer. The final histopathologic report showed poorly differentiated endometrial adenocarcinoma with cervical extension, although the FDG PET CT and MRI findings were suggestive of concordant cervical and endometrial cancer. Although histopathologic confirmation is necessary for final diagnosis, MRI and FDG PET CT studies may aid in the differential diagnosis. A metastatic cervical mass

  17. Laminoplasty for Cervical Myelopathy

    OpenAIRE

    Ito, Manabu; Nagahama, Ken

    2012-01-01

    This article reviews cervical laminoplasty. The origin of cervical laminoplasty dates back to cervical laminectomy performed in Japan ~50 years ago. To overcome poor surgical outcomes of cervical laminectomy, many Japanese orthopedic spine surgeons devoted their lives to developing better posterior decompression procedures for the cervical spine. Thanks to the development of a high-speed surgical burr, posterior decompression procedures for the cervical spine showed vast improvement from the ...

  18. Liquid abrasive pressure pot scoping tests report

    International Nuclear Information System (INIS)

    The primary initiatives of the LITCO Decontamination Development group at the Idaho Chemical Process Plant (ICPP) are the development of methods to eliminate the use of sodium bearing decontamination chemicals and minimization of the amount of secondary waste generated during decontamination activities. In July of 1994, a Commerce Business Daily (CBD) announcement was issued by the INEL to determine commercial interest in the development of an in-situ liquid abrasive grit blasting system. As a result of the CBD announcement, Klieber ampersand Schulz issued an Expression of Interest letter which stated they would be interested in testing a prototype Liquid Abrasive Pressure Pot (LAPP). LITCO's Decontamination group and Kleiber ampersand Schulz entered into a Cooperative Research and Development Agreement (CRADA) in which the Decontamination Development group tested the prototype LAPP in a non-radioactive hot cell mockup. Test results are provided

  19. Cryogenically assisted abrasive jet micromachining of polymers

    International Nuclear Information System (INIS)

    The abrasive jet micromachining (AJM) of elastomers and polymers such as polydimethylsiloxane (PDMS), acrylonitrile butadiene styrene (ABS) and polytetrafluoroethylene (PTFE) for use in micro-fluidic devices was found to be very slow or impossible at room temperature. To enhance the material removal rate in such materials, a stream of liquid nitrogen (LN2) was injected into the abrasive jet, cooling the target to cryogenic temperatures. Erosion rate measurements on the three polymeric materials (PDMS, ABS and PTFE) with and without the use of LN2 were compared along with the profiles of micromachined channels and holes. It was found that the use of LN2 cooling caused brittle erosion in PDMS, allowing it to be micromachined successfully. An erosion rate increase was also observed in PTFE and ABS at high and intermediate impact angles. The use of LN2 also was found to reduce particle embedding

  20. Diagnosis of cervical cancer with transvaginal color Doppler sonography

    Directory of Open Access Journals (Sweden)

    Li-bo DENG

    2011-09-01

    Full Text Available Objective To investigate the imaging features of cervical cancer by transvaginal color Doppler sonography(TVCS,and evaluate the diagnostic value of TVCS.Methods A hundred and thirty cases of cervical intraepithelial neoplasia(CIN grade Ⅰ-Ⅱ and cervical cancer,diagnosed by Thinprep cytologic test(TCT,cervical biopsy and pathological examination,received TVCS examination.The image characters and color Doppler flow imaging(CDFI were collected and analyzed.Another 41 cases with normal cervices as determined by inspection and cytological examination were involved as control.Results In order of normal cervix,CIN,cancer in situ and cervical cancer,the cervical diameter showed a tendency of increase,also with an increase incidence of low-level echo focus in cervix.As a specific image of cervical cancer,the low level echo focus occurred only in cervical cancer with a specificity of 100%.The absence of mucosal line in cervical canal was a specific character of stage Ⅱ cervical cancer with a specificity of 100%.CDFI and resistance index(RI revealed that the local blood flow was more abundant in invasive cancer than in CIN and cancer in situ,and significant difference was found between stage Ⅰ and stage Ⅱ cervical cancer(P < 0.05.The sensitivity and specificity of enlarged cervical diameters in diagnosis of cervical cancer were 89.1% and 82.8%.The specificity of cervical low level echo focus in diagnosis of cervical cancer and invasive cervical cancer were 100% and 94.8%,respectively.The specificity of abundant blood flow in dendritic form in diagnosis of invasive cervical cancer was 100%.Conclusions Invasive cervical cancer may present several specific features in TVCS images.TVCS examination is of high reliability in diagnosis of invasive cervical cancer,but is not so reliable in diagnosing precancerous lesion and preinvasive cancer.Combined with other auxiliary examinations,TVCS could be considered as one of the methods to diagnose cervical

  1. Automated image analysis of uterine cervical images

    Science.gov (United States)

    Li, Wenjing; Gu, Jia; Ferris, Daron; Poirson, Allen

    2007-03-01

    Cervical Cancer is the second most common cancer among women worldwide and the leading cause of cancer mortality of women in developing countries. If detected early and treated adequately, cervical cancer can be virtually prevented. Cervical precursor lesions and invasive cancer exhibit certain morphologic features that can be identified during a visual inspection exam. Digital imaging technologies allow us to assist the physician with a Computer-Aided Diagnosis (CAD) system. In colposcopy, epithelium that turns white after application of acetic acid is called acetowhite epithelium. Acetowhite epithelium is one of the major diagnostic features observed in detecting cancer and pre-cancerous regions. Automatic extraction of acetowhite regions from cervical images has been a challenging task due to specular reflection, various illumination conditions, and most importantly, large intra-patient variation. This paper presents a multi-step acetowhite region detection system to analyze the acetowhite lesions in cervical images automatically. First, the system calibrates the color of the cervical images to be independent of screening devices. Second, the anatomy of the uterine cervix is analyzed in terms of cervix region, external os region, columnar region, and squamous region. Third, the squamous region is further analyzed and subregions based on three levels of acetowhite are identified. The extracted acetowhite regions are accompanied by color scores to indicate the different levels of acetowhite. The system has been evaluated by 40 human subjects' data and demonstrates high correlation with experts' annotations.

  2. An interdisciplinary approach for the management of noncarious lesions

    Science.gov (United States)

    Purushotham, Sahana; Manjunath, Nandini; D’Souza, Melba Lisa; Shetty, Roshan

    2016-01-01

    Miller's class III gingival recession is a common entity observed in individuals, posing a difficult situation for the clinicians to treat. Large fenestration defects with cervical abrasion compromise the esthetics resulting in poor prognosis. Obtaining predictable and esthetic root coverage has become an integral part of periodontal therapy. The present case report describes a situation where class III gingival recession with cervical abrasion was seen in the lower central incisors. The patient was successfully treated with a combination of restorations (Filtek Z350® composite resin) to fill the defect, followed by fenestration procedure to increase the vestibular depth and subsequently with grafting procedure (soft tissue autograft with bovine-derived xenograft collagen [Bio-oss]). Though the results were not tangible esthetically, it was functionally successful as evidenced during the follow-up period. PMID:27143838

  3. The measurement of abrasive particles velocities in the process of abrasive water jet generation

    Czech Academy of Sciences Publication Activity Database

    Zeleňák, Michal; Foldyna, Josef; Říha, Zdeněk

    Melville : American Institute of Physics Inc, 2014 - (Lenhard, R.; Kaduchova, K.), s. 276-280 ISBN 978-0-7354-1244-6. ISSN 0094-243X. - (AIP Conference Proceedings. 1608). [The Application of experimental and numerical method s in fluid mechanics and energetics 2014 /19./. Liptovský Ján (SK), 09.04.2014-11.04.2014] R&D Projects: GA MŠk ED2.1.00/03.0082; GA MPO FR-TI3/733 Institutional support: RVO:68145535 Keywords : abrasive cutting head * velocities of abrasive particles * abrasive water jet generation Subject RIV: JQ - Machines ; Tools http://scitation.aip.org/content/aip/proceeding/aipcp/10.1063/1.4892749

  4. [Cervical Spondylotic Amyotrophy].

    Science.gov (United States)

    Sonoo, Masahiro

    2016-05-01

    Keegan (1965) reported a patient who presented with "dissociated motor loss," an acute paralysis of the upper extremity with minimal sensory signs and no long tract signs, and documented an anterior root lesion following autopsy. Sobue et al. (1975) reported similar cases using the term "cervical spondylotic amyotrophy (CSA)," but postulated pathology of the anterior horn. Although Keegan's "dissociated motor loss" surely referred to isolated motor paresis with no or minimal sensory signs, contrary to existing criticism, a more general term, CSA, should be preferred. CSA is divided into proximal and distal types. Distal CSA often presents with a drop finger, and thus may be misdiagnosed as posterior interosseous nerve palsy. Documentation of the involvement of ulnar muscles by clinical signs and EMG would lead to the diagnosis of distal CSA. Proximal CSA may be confused with neuralgic amyotrophy (NA), although the sparing of the serratus anterior and the stereotypic involvement of deltoid, infraspinatus, biceps brachii, and brachioradialis suggest CSA. Cervical MRI is not diagnostic in around half of CSA cases, and denervation in paraspinal EMG is a more sensitive test that can exclude NA. Amyotrophic lateral sclerosis is another important differential diagnosis for CSA. PMID:27156504

  5. Aberrant DNA methylation in cervical carcinogenesis

    Institute of Scientific and Technical Information of China (English)

    Hui-Juan Yang

    2013-01-01

    Persistent infection with high-risk types of human papillomavirus(HPV) is known to cause cervical cancer; however,additional genetic and epigenetic alterations are required for progression from precancerous disease to invasive cancer.DNA methylation is an early and frequent molecular alteration in cervical carcinogenesis.In this review,we summarize DNA methylation within the HPV genome and human genome and identify its clinical implications.Methylation of the HPV long control region (LCR) and L1 gene is common during cervical carcinogenesis and increases with the severity of the cervical neoplasm.The L1 gene of HPV16 and HPV18 is consistently hypermethylated in invasive cervical cancers and can potentially be used as a clinical marker of cancer progression.Moreover,promoters of tumor suppressor genes (TSGs) involved in many cellular pathways are methylated in cervical precursors and invasive cancers.Some are associated with squamous cell carcinomas,and others are associated with adenocarcinomas.Identification of methylated TSGs in Pap smear could be an adjuvant test in cervical cancer screening for triage of women with high-risk HPV,atypical squamous cells of undetermined significance,or low grade squamous intraepithelial lesion (LSIL).However,consistent panels must be validated for this approach to be translated to the clinic.Furthermore,reversion of methylated TSGs using demethylating drugs may be an alternative anticancer treatment,but demethylating drugs without toxic carcinogenic and mutagenic properties must be identified and validated.

  6. Therapeutic Vaccination for HPV Induced Cervical Cancers

    Directory of Open Access Journals (Sweden)

    Joeli A. Brinkman

    2007-01-01

    Full Text Available Cervical Cancer is the second leading cause of cancer–related deaths in women worldwide and is associated with Human Papillomavirus (HPV infection, creating a unique opportunity to treat cervical cancer through anti-viral vaccination. Although a prophylactic vaccine may be available within a year, millions of women, already infected, will continue to suffer from HPV-related disease, emphasizing the need to develop therapeutic vaccination strategies. A majority of clinical trials examining therapeutic vaccination have shown limited efficacy due to examining patients with more advanced-stage cancer who tend to have decreased immune function. Current trends in clinical trials with therapeutic agents examine patients with pre-invasive lesions in order to prevent invasive cervical cancer. However, longer follow-up is necessary to correlate immune responses to lesion regression. Meanwhile, preclinical studies in this field include further exploration of peptide or protein vaccination, and the delivery of HPV antigens in DNA-based vaccines or in viral vectors. As long as pre-clinical studies continue to advance, the prospect of therapeutic vaccination to treat existing lesions seem good in the near future. Positive consequences of therapeutic vaccination would include less disfiguring treatment options and fewer instances of recurrent or progressive lesions leading to a reduction in cervical cancer incidence.

  7. Telomerase in (pre)neoplastic cervical disease

    NARCIS (Netherlands)

    Wisman, GBA; De Jong, S; Meersma, GJ; Helder, MN; Hollema, H; de Vries, EGE; Keith, WN; van der Zee, AGJ

    2000-01-01

    This study was performed to determine upregulation of the human telomerase RNA component (hTR) and mRNA of the catalytic subunit of telomerase (hTERT) in (pre)malignant cervical lesions, to analyze possible intralesional heterogeneity of hTR expression, and to relate hTR and hTERT mRNA levels to tel

  8. Epidemiology and biology of cervical cancer.

    Science.gov (United States)

    Schoell, W M; Janicek, M F; Mirhashemi, R

    1999-01-01

    Worldwide, cancer of the cervix is the second leading cause of cancer death in women: each year, an estimated 500,000 cases are newly diagnosed. Among populations, there are large differences in incidence rates of invasive cervical cancer: these reflect the influence of environmental factors, screening Papanicolaou (Pap) tests, and treatment of pre-invasive lesions. The high-risk human papillomavirus (HPV) subtypes 16, 18, 31, 33, and 51 have been recovered from more than 95% of cervical cancers. We have made great strides in understanding the molecular mechanism of oncogenesis of this virus, focusing on the action of the E6 and E7 viral oncoproteins. These oncoproteins function by inactivating cell cycle regulators p53 and retinoblastoma (Rb), thus providing the initial event in progression to malignancy. Cervical cancers develop from precursor lesions, which are termed squamous intraepithelial lesions (SIL) and are graded as high or low, depending on the degree of disruption of epithelial differentiation. Viral production occurs in low-grade lesions and is restricted to basal cells. In carcinomas, viral DNA is found integrated into the host genome, but no viral production is seen. The well-defined pre-invasive stages, as well as the viral factors involved at the molecular level, make cervical carcinoma a good model for investigating immune therapeutic alternatives or adjuvants to standard treatments. PMID:10225296

  9. Analysis of the Functional Independence Measure Value of Cervical Spine Injury Patients with Conservative Management

    Directory of Open Access Journals (Sweden)

    M. Zafrullah Arifin

    2012-06-01

    Full Text Available Analysis of the Functional Independence Measure Value of Cervical Spine Injury Patients with Conservative Management. Cervical spine injury is one of the most common spinal cord injuries in trauma patients. From 100,000 spinal cord injury cases reported in the United States of America (2008, sixty seven percent involve cervical spine injury. American Spinal Cord Injury Association (ASIA impairment score is used as an initial assessment but not enough attention prognostic outcome of these patients was paid to. The objective of this study is to analyze the value of functional independence measure (FIM cervical spine injury patients with conservative management and its correlation with age, sex, type of trauma, onset of trauma, cervical abnormalities, type of cervical spine lesion and ASIA impairment score. A prospective cohort study was performed to all patients with cervical spine injury treated inNeurosurgery Department of Dr. Hasan Sadikin Hospital Bandung that fullfiled the inclusion criteria. The subjects were classified based on age, sex, single/multiple trauma, acute /chronic, cervical abnormalities, complete/incomplete lesion and ASIA impairment score. The FIM examination was performed in Outpatient clinic of Neurosurgery. T-test and chi-square test was done to analyze the data. There were 17 cervical spine injury patients treated in Neurosurgery Department of Dr. Hasan Sadikin Hospital during April 2009–April 2010. The average FIM value of cervical spine injury in those patients is 4+ 1.63 by cohort prospective study. There were no correlation between FIM value with age, sex, type of trauma, onset of trauma and cervical abnormalities. Significant correlations were found between FIM value with type of cervical spine lesion and ASIA impairment score in cervical spine patients. Type of cervical spine lesion and ASIA impairment score have significant correlation with FIM value of patients in 6 months after cervical injury.

  10. Abrasion Resistance Comparison between Rotor and Ring Spun Yarn

    Institute of Scientific and Technical Information of China (English)

    YANG Jian-ping; YU Chong-wen

    2002-01-01

    On the base of literature review and the analysis of yarn properties, yarn structure and some other facts, the abrasion resistance of both rotor spun yarn and ring spun yarns are discussed. The results show that with the same raw material and twist, the rotor spun yarn has lower abrasion resistance than that of ring spun yarn, because of the higher twist employed, the abrasion resistance of rotor spun yarn is higher than that of ring spun yarn.

  11. Tangental Turning of Incoloy Alloy 925 Using Abrasive Water Jet

    OpenAIRE

    Cárach, J.; S. Hloch; Hlaváček, P.; K. Vasilko; Lehocká, D.

    2015-01-01

    The paper deals with tangential turning of Incoloy alloy 925 with the diameter 50mm using the abrasive water jet. Experiment was done using the abrasive water jet of pressure p=400MPa and traverse speed at levels of v=1,5;3;4,5;6;7,5;9mm min-1. the abrasive particles were feeded to the water jet in the amount of 400 g min-1. Revolution of Incoloy workpiece during turning was n=34rpm.

  12. The Abrasion-resistance Investigation of Rubberized Concrete

    Institute of Scientific and Technical Information of China (English)

    KANG Jingfu; ZHANG Bo; LI Guangyu

    2012-01-01

    The abrasion resistance properties of rubberized concrete were comparatively studied by taking silica fume and crumb tire rubber as the additives.The abrasion tests were conducted in accordance with the Chinese standard test method DL/T 5150-2001,two recommended test methods:under water method and ring method,were used.The crumb tire rubbers with the sieve size of 8-mesh and 16-mesh were incorporated into the concrete by replacing same volume of sand and as an additive.The abrasion resistance of concrete was evaluated according to the abrasion resistance strength and the mass loss.Test results show that the addition of silica fume enhanced both compressive strength and abrasion resistance of concrete,and the addition of crumb rubber reduced the compressive strength but increased notably the abrasion resistance of the concrete.Silica fume concrete performed a better abrasion resistance than control concrete,and the rubberized concrete performed a much better abrasion resistance than silica fume concrete.The abrasion resistance of rubberized concrete increased with the increase of rubber content.

  13. Machining human dentin by abrasive water jet drilling.

    Science.gov (United States)

    Kohorst, Philipp; Tegtmeyer, Sven; Biskup, Christian; Bach, Friedrich-Wilhelm; Stiesch, Meike

    2014-01-01

    The aim of this experimental in-vitro study was to investigate the machining of human dentin using an abrasive water jet and to evaluate the influence of different abrasives and water pressures on the removal rate. Seventy-two human teeth had been collected after extraction and randomly divided into six homogeneous groups (n=12). The teeth were processed in the area of root dentin with an industrial water jet device. Different abrasives (saccharose, sorbitol, xylitol) and water pressures (15 or 25 MPa) were used in each group. Dimensions of dentin removal were analysed using a stripe projection microscope and both drilling depth as well as volume of abrasion were recorded. Morphological analyses of the dentin cavities were performed using scanning electron microscopy (SEM). Both drilling depth and volume of abrasion were significantly influenced by the abrasive and the water pressure. Depending on these parameters, the drilling depth averaged between 142 and 378 μm; the volume of abrasion averaged between 0.07 and 0.15 mm3. Microscopic images revealed that all cavities are spherical and with clearly defined margins. Slight differences between the abrasives were found with respect to the microroughness of the surface of the cavities. The results indicate that abrasive water jet machining is a promising technique for processing human dentin. PMID:24642975

  14. Incidence of lameness and abrasions in piglets in identical farrowing pens with four different types of floor

    Directory of Open Access Journals (Sweden)

    Nilsson Ebba

    2009-05-01

    Full Text Available Abstract Background Lameness in piglets is a major animal welfare issue. Floor abrasiveness is a common cause of superficial injury in piglets in farrowing pens. The abrasion achieved may act as a gate for infections, which in turn may induce development of infectious arthritis. In this study, the influence of improvements of the floor quality and of increased ratios of straw in identical farrowing pens was measured. Methods The study was carried out at a herd with four identical farrowing units with solid concrete floor bedded with 1 kg chopped straw per sow and 1 hg per piglet and day. Nothing was changed in the management of the four identical farrowing units, but four experimental groups were created: Group I – control, Group II – the amount of bedding was doubled. The surface of the floor was repaired in two units, Group III – Piglet Floor®, Flowcrete Sweden AB, Perstorp, Sweden and Group IV – Thorocrete SL®, Växa Halland, Sweden. Three farrowing batches were studies in each unit. In total, 93 litters (1,073 piglets were examined for foot and skin lesions until the age of 3 weeks. The occurrence of lameness was registered until weaning at an average age of 4.5 weeks. Twenty seven lame piglets were culled instead of medicinally treated and subjected to necropsy including histopathological and microbiological examinations. Isolates of streptococci, staphylococci and E. coli were tested with respect to antimicrobial resistance. Results Piglet born on the repaired floors had the lowest prevalences of abrasions at carpus. Also the doubled straw ration decreased the abrasions. Skin lesions at carpus decreased significantly in magnitude in all four systems from day 10. At day 3, the sole bruising scores of the control unit were greater than the other three units (p Streptococcus dysgalactiae subsp. equisimilis (60%, Staphylococcus hyicus subsp. hyicus (35% and Escherichia coli (5%. These isolates were sensitive to all antibiotics

  15. Abrasive water jet: a complementary tool

    Directory of Open Access Journals (Sweden)

    Duarte, J. P.

    1998-04-01

    Full Text Available The abrasive water jet is a powerful cutting tool, whose main advantages lie in the absence of thermal effects and the capability of cutting highly thick materials. Compared with Laser, the abrasive water jet allows the cutting of a larger range of thicknesses and a wider variety of materials such as: ornamental stones, metals, polymers, composites, wood, glass and ceramics. The application of this technology has suffered an extensive growth, with successful applications in varied industrial sectors like the automotive, aerospace, textile, metalworking, ornamental stones, etc. The present communication aims at introducing the abrasive water jet as a complementary tool to laser cutting, presenting its advantages by showing some documented examples of pieces cut for different industries.

    O jacto de água abrasivo é uma poderosa ferramenta de corte, tendo como principais vantagens a ausência de processo térmico e permitir o corte de elevadas espessuras. Comparativamente com o laser o jacto de água abrasivo permite cortar uma maior gama de espessuras, e uma maior diversidade de materiais: rochas ornamentais, metais, polimeros, compósitos, madeiras, vidro e cerâmicos. A aplicação desta tecnologia tem sofrido um crescimento acentuado, existindo aplicações de sucesso nos mais variados sectores industriáis como a indústria automóvel, aeroespacial, têxtil, metalomecânica e rochas ornamentáis. Esta comunição pretende apresentar o corte por jacto de agua abrasivo como uma ferramenta de corte complementar ao corte por laser, apresentando as suas vantagens documentadas através de alguns exemplos de peças executadas para as diferentes indústrias.

  16. Research on Premixed Abrasive Jet Derusting Machine

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The structure, working principles, and main technological parameters of the premajet derusting machineare introduced. Experiments were made to test the relationship among such jet parameters as working pressure,rate of water flow, abrasive weight consistency and derusting efficiency. Reasonable parameters were decided. Re-su lts prove that the derusting machine is characterized by its high derusting efficiency (as high as 20 m2/h), goodderusting quality (as good as ISO8501-1 Sa 2.5), and low specific power consumption (about 0.3 kW · h/m2).Therefore it is a new type of high efficiency derusting machine.

  17. Testing of Mineral types of abrasives for abrasive water jet cutting

    Czech Academy of Sciences Publication Activity Database

    Foldyna, Josef; Martinec, Petr; Sitek, Libor

    Vol. 1. St. Louis : WJTA, 2001 - (Hashish, M.), s. 291-303 [2001 WJTA American Water jet Conference. Minneapolis (US), 18.08.2001-21.08.2001] R&D Projects: GA AV ČR KSK3012103 Keywords : water jet * cutting * abrasive Subject RIV: DB - Geology ; Mineral ogy

  18. Impact of toothpaste slurry abrasivity and toothbrush filament stiffness on abrasion of eroded enamel - an in vitro study

    OpenAIRE

    Wiegand, Annette; Schwerzmann, Martina; Sener, Beatrice; Magalhães, Ana C.; Roos, Malgorzata; Ziebolz, Dirk; Imfeld, Thomas; Attin, Thomas

    2008-01-01

    OBJECTIVE: Toothbrush abrasion is significant in the development of tooth wear, particularly when combined with erosion. This in vitro study aimed to evaluate the impact of toothpaste slurry abrasivity and toothbrush filament stiffness on abrasion of eroded enamel. MATERIAL AND METHODS: Eroded enamel samples (hydrochloric acid, pH: 2.6, 15 s) were brushed with 40 strokes in an automatic brushing machine using manual toothbrushes with different filament stiffness (filament diameter: 0.15, 0.20...

  19. Using Intervention Mapping as a Participatory Strategy: Development of a Cervical Cancer Screening Intervention for Hispanic Women

    Science.gov (United States)

    Byrd, Theresa L.; Wilson, Katherine M.; Smith, Judith Lee; Heckert, Andrea; Orians, Carlyn E.; Vernon, Sally W.; Fernandez-Esquer, Maria E.; Fernandez, Maria E.

    2012-01-01

    Cervical cancer is preventable with treatment of precancerous lesions and treatable at early stages. Hispanics have higher rates of cervical cancer and lower rates of screening. "Ayndando a las Mujeres con Informaccion, Guia, y Amor para su Salud" (AMIGAS) is an intervention to increase cervical cancer screening in U.S. women of Mexican origin.…

  20. Ultrasonic Abrasion: An Alternative for Cavity Preparation

    Directory of Open Access Journals (Sweden)

    Áurea Simone Barrôso VIEIRA

    2007-05-01

    Full Text Available Introduction: Restorative dentistry aims to repair damages caused by caries disease. Along the years, researchers have developed effective and less invasive methods with the goal of preserving the teeth from caries destruction. Therefore, the improvement of scientific knowledge, auxiliary diagnostic systems, dental materials, and new instruments has changed the approaches and treatments in this field. In addition to conservative removal of carious tissue, patient’s comfort has also become a concern in modern dentistry.Purpose: Considering that ultrasonic abrasion has attracted great interest of dental professionals, this article discusses an alternative technique for cavity preparation by literature review, addressing its indications, contra-indications, advantages and limitations compared to the conventional high-speed method.Conclusion: There are not many studies on this subject. The available studies have demonstrated several qualities of the ultrasonic abrasion system, but some aspects remain unclear. Therefore, it is important to highlight that laboratorial and clinical studies in primary/permanent teeth should be conducted to elucidate questionable issues, such as time of cavity preparation, topography, presence of smear layer and microleakage, in order to offer safety to the extensive use of this new technology for both the professional and the patient. In this context, the dentist should always be attentive to innovations referring to minimally invasive techniques.

  1. Research on the Clinical Value of Vaginal Ultrasound in the Diagnosis of Early Cervical Cancer and Precancerous Lesions%阴道超声在早期宫颈癌及癌前病变诊断中的临床价值研究

    Institute of Scientific and Technical Information of China (English)

    张利; 赵华巍; 郭丽娟

    2016-01-01

    目的:探讨阴道超声对早期宫颈癌及癌前病变的诊断价值。方法以43例宫颈癌患者作为研究对象,其中早期宫颈癌27例,癌前病变16例。所有患者均于术前确诊并行手术治疗。另选取体检无妇科病史的30例妇女作为对照组,对三组的阴道超声声像特征进行对比分析。结果阴道超声诊断为宫颈癌前病变者16例,准确率为81.3%;超声诊断为早期宫颈癌者25例,诊断准确率为92.6%。三组的宫颈厚径与宫颈内膜厚度比较存在显著性差异( P<0.05),三组间关系为:正常对照组<癌前病变组<早期宫颈癌组。正常对照组中均未见宫颈线中断与宫颈内出现强回声或低回声团,15例测到丰富血流;癌前病变组宫颈线中断2例,3例可见宫颈内出现强回声或低回声团,血流丰富8例;早期宫颈癌组中宫颈线中断10例,宫颈内出现强回声或低回声团8例,血流丰富22例;三组间存在显著性差异( P<0.05)。3组PSV与RI比较存在显著性差异(P<0.05);PSV:正常对照组<病前病变组<早期宫颈癌组;RI:正常对照组>病前病变组>早期宫颈癌组。结论阴道超声对早期宫颈癌及癌前病变具有较高的敏感度,可为临床提供有价值的信息,可作为细胞学检查与妇科检查的有效补充,减少漏诊或误诊病例的发生。%Objective To study the clinical value of vagianl ultrasound in the diagnosis of early cervical cancer and pre -cancerous lesions .Methods 43 cases of patients with cervical cancer were selected ,in which,27 cases were early cervical cancer and 16 cases were precancerous lesions .All patients were diagnosed before operation .30 cases of women without history of gynae-cology and symptoms were selected as the control group .The characteristics of vaginal ultrasound acoustic images were compared and analyzed.Results Among these cases,16 cases were

  2. Abrasion of 6 dentifrices measured by vertical scanning interference microscopy

    Directory of Open Access Journals (Sweden)

    Florence Pascaretti-Grizon

    2013-09-01

    Full Text Available OBJECTIVES: The abrasion of dentifrices is well recognized to eliminate the dental plaque. The aims of this study were to characterize the abrasive powders of 6 dentifrices (3 toothpastes and 3 toothpowders and to measure the abrasion on a test surface by Vertical Scanning Interference microscopy (VSI. MATERIAL AND METHODS: Bright field and polarization microscopy were used to identify the abrasive particles on the crude dentifrices and after prolonged washes. Scanning electron microscopy and microanalysis characterized the shape and nature of the particles. Standardized and polished blocks of poly(methylmethacrylate were brushed with a commercial electric toothbrush with the dentifrices. VSI quantified the mean roughness (Ra and illustrated in 3D the abraded areas. RESULTS: Toothpastes induced a limited abrasion. Toothpowders induced a significantly higher roughness linked to the size of the abrasive particles. One powder (Gencix® produced a high abrasion when used with a standard testing weight. However, the powder is based on pumice particles covered by a plant homogenate that readily dissolves in water. When used in the same volume, or after dispersion in water, Ra was markedly reduced. CONCLUSION: Light and electron microscopy characterize the abrasive particles and VSI is a new tool allowing the analysis of large surface of abraded materials.

  3. 29 CFR 1910.215 - Abrasive wheel machinery.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Abrasive wheel machinery. 1910.215 Section 1910.215 Labor... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Machinery and Machine Guarding § 1910.215 Abrasive wheel machinery. (a... wheel in motion. (5) Excluded machinery. Natural sandstone wheels and metal, wooden, cloth, or...

  4. Testing of Commercial Cutting Heads for Abrasive Water Jet Technology

    OpenAIRE

    Klich, J. (Jiří); Hlaváček, P.; M. Zeleňák; Sitek, L. (Libor); Foldyna, J.

    2013-01-01

    Five different cutting heads designed for cutting by high-speed abrasive water jet technology were tested from cutting ability point of view. Straight kerfs were cut in several metal materials by abrasive water jet. Material removal volume was determined as a measure of performance of specific cutting head. Quality of cutting surface was observed, too. Results are compared and discussed.

  5. Abrasion Resistant Refractory Materials GB/T 23294-2009

    Institute of Scientific and Technical Information of China (English)

    Yu Lingyuan

    2009-01-01

    @@ 1 Scope This standard specifies the definition, classification, technical requirements, test methods, quality appraisal procedure, packing, marking, transportation, storage, and quality certificate of abrasion resistant refractory materials. This standard is applicable to abrasion resistant refractory materials for circulating fluidized bed boilers, daily waste incinerator, industrial waste incinerator, medical waste incinerator, ordinary solid waste incinerator, hazardous waste incinerator, etc.

  6. Two cases of high cervical cord tumor

    International Nuclear Information System (INIS)

    Two cases of high cervical cord tumor are presented. Case 1 is an intradural extramedullary meningioma located at the foramen magnum. Case 2 is an extradural neurinoma originated from left C2 spinal nerve root. In each case high resolution computed tomography and myelography, especially that of axial view, visualized extramedullary mass lesion.FIn recent years it has been stressed that high resolution computed tomography is useful in the diagnosis of high cervical cord lesion, and this idea is quite reasonable from our experiences. On the other hand, it has been mentioned that myelography often gives false negative results as far as high cervical cord lesion is concerned, which is mainly because relative width of the subarachnoid space in the region of the foramen magnum.FOur experience indicated that in myelographic examination of foramen magnum tumor it is advisable to add axial view to ordinary P-A and lateral views. Bacause axial high cervical myelography gives an image similar to computed tomogram of this region, this technique not only increases the diagnostic value of myelography but also, in some cases, substitutes for computed tomography which costs very much. (author)

  7. 高危型 HPV 结合液基细胞学技术在宫颈癌前病变诊断中的应用%Application of High-risk HPV Combined with Liquid-based Cytology Technology in the Diagnosis of Cervical Lesions

    Institute of Scientific and Technical Information of China (English)

    颜萍; 龚旭华

    2014-01-01

    Objective To investigate the application of high-risk HPV genotyping assay combined with liquid-based cy-tology for cervical lesions .Methods Liquid-based cytology samples of 204 cases of cervical cancer were detected by high-risk HPV genotyping assay ,and were compared with cervical biopsy results .Results 138 patients were TCT-positive combined with HPV infection,LSIL showed that HPV-positive was 40 cases (29.0%),HSIL showed that HPV-positive was 10 cases (7.2%), ASCUS showed that HPV-positive was 80 cases(58.0%),SCC showed that HPV-positive was 8 cases (5.8%).High-risk HPV was 42 cases,and positive rate was 30.4%.Samples of different types of high-risk HPV infection had significant difference ( P<0.05).When TCT and HPV were both ( -),there had no high grade lesion .When HPV-positive and TCT abnormal both oc-curred,detection rate of ≥CINⅠwas 34.8%.When TCT was abnormal HPV (-),the detection rate was 47.8%.Conclusion High-risk HPV genotyping assay combined with liquid-based cervical cytology is a valuable method for early screening of cervical cancer,the result is more reliable than single inspection .%目的:探讨高危型HPV基因分型检测结合液基细胞学检查在宫颈癌前病变诊断中的应用。方法纳入204例宫颈癌患者,采集液基细胞标本后,进行高危型HPV基因分型检测,并与宫颈活检结果进行比较分析。结果138例患者显示TCT阳性合并HPV感染,其中LSIL显示HPV阳性40例(29.0%),HSIL显示HPV阳性10例(7.2%),AS-CUS显示HPV阳性80例(58.0%),SCC显示HPV阳性8例(5.8%)。42例HPV高危型,阳性率为30.4%。不同类型标本HPV高危型感染率具有显著性差异( P<0.05)。 TCT和HPV均为(-)时,则未发生高度病变。 HPV阳性和TCT异常同时存在时,≥CINⅠ的检出率为34.8%。仅TCT异常而HPV(-)时,检出率为47.8%。结论高危型HPV基因分型检测结合液基细胞学检查是极具价

  8. Lung scintigraphy evaluation in workers exposed to abrasive dusts; Avaliacao cintilografica pulmonar em trabalhadores de industria de abrasivos

    Energy Technology Data Exchange (ETDEWEB)

    Terra Filho, Mario

    1995-12-31

    The production process of abrasives use aluminium, or silicon carbide a synthetic material with a hardness only slightly less than that of a diamond. It is popularly known as carborundum since it was first manufactured as an abrasive in 1891, produced by the fusion of high grade silica and petroleum coke with sawdust. For many years silicon carbide was thought not to give rise to pulmonary lesions. Recently several researchers suggested the existence of a carborundum pneumoconiosis. The aim of this study was to evaluate the role of the pulmonary clearance of {sup 99m} Technetium chelated to diethylene-triamine penta-acetate ({sup 99m} Tc DTPA), and {sup 67} Gallium lung scanning in workers exposed to abrasive dusts. Thirty seven subjects, 13 smokers and 24 nonsmokers and ex smokers were studied. In 32 (86,48%) {sup 67} Gallium lung scanning was positive including 13 (40,62%) retired workers. We conclude that non smoking workers of abrasives plants have a pulmonary alveolar epithelial permeability disturbance similar as observed in smoking workers and smoking controls. Most workers, ex-workers of these industries and in patients with carborundum pneumoconiosis there is an evidence of pulmonary inflammation measured with abnormal {sup 67} Gallium lung scan. (author) 101 refs., 2 figs., 11 tabs.

  9. Marijuana Use is Not Associated with Cervical Human Papillomavirus Natural History or Cervical Neoplasia in HIV-seropositive or HIV-seronegative Women

    OpenAIRE

    D’Souza, G; Palefsky, J.M.; Zhong, Y; Minkoff, H; Massad, L.S.; Anastos, K; Levine, AM; Moxley, M; Xue, X.; Burk, R; Strickler, HD

    2010-01-01

    Marijuana use was recently reported to have a positive cross-sectional association with human papillomavirus (HPV)-related head and neck cancer. Laboratory data suggest that marijuana could have an immunomodulatory effect. Little is known, however, regarding the effects of marijuana use on cervical HPV or neoplasia. Therefore, we studied the natural history (ie, prevalence, incident detection, clearance/persistence) of cervical HPV and cervical neoplasia (ie, squamous intraepithelial lesions ...

  10. Risk for cervical intraepithelial neoplasia grade 3 or worse in relation to smoking among women with persistent human papillomavirus infection

    DEFF Research Database (Denmark)

    Jensen, Kirsten Egebjerg; Schmiedel, Sven; Frederiksen, Kirsten;

    2012-01-01

    were also conducted. Hazard ratios (HRs) for a diagnosis of cervical intraepithelial neoplasia grade 3 or worse/high-grade squamous intraepithelial lesions or worse (CIN3+) and the corresponding 95% confidence intervals (CIs) were calculated in the 2 groups. RESULTS: Among high-risk HPV positive women......-grade cervical lesions in women with persistent high-risk HPV infection. Impact: Our study adds to the understanding of the role of smoking in the natural history of HPV and cervical carcinogenesis....

  11. Hydro-abrasive erosion: Problems and solutions

    International Nuclear Information System (INIS)

    The number of hydro power plants with hydro-abrasive erosion is increasing worldwide. An overall approach is needed to minimize the impact of this phenomenon. Already at the start of the planning phase an evaluation should be done to quantify the erosion and the impact on the operation. For this, the influencing parameters and their impact on the erosion have to be known. The necessary information for the evaluation comprises among others the future design, the particle parameters of the water, which will pass the turbine, and the power plant owner's framework for the future operation like availability or maximum allowable efficiency loss, before an overhaul needs to be done. Based on this evaluation of the erosion, an optimised solution can then be found, by analysing all measures in relation to investments, energy production and maintenance costs as decision parameters. Often a more erosion-resistant design, instead of choosing the turbine design with the highest efficiency, will lead to higher revenue. The paper will discuss the influencing parameters on hydro-abrasive erosion and the problems to acquire this information. There are different optimisation possibilities, which will be shown in different case studies. One key aspect to reduce the erosion and prolong the operation time of the components is to coat all relevant parts. But it is very important that this decision is taken early in the design stage, as the design has to be adapted to the requirements of the coating process. The quality of coatings and their impact on the operation will be discussed in detail in the paper as due to the non-availability of standards many questions arise in projects

  12. Cervical Cancer Screening

    Science.gov (United States)

    ... Cancer found early may be easier to treat. Cervical cancer screening is usually part of a woman's health ... may do more tests, such as a biopsy. Cervical cancer screening has risks. The results can sometimes be ...

  13. Cervical Cancer Stage IVB

    Science.gov (United States)

    ... of the body, such as the lymph nodes, lung, liver, intestine, or bone. Stage IVB cervical cancer. Topics/Categories: Anatomy -- Gynecologic Cancer Types -- Cervical Cancer Staging Type: Color, Medical Illustration Source: National Cancer Institute ...

  14. Comparison of abrasion resistance of selected constructional materials

    Directory of Open Access Journals (Sweden)

    M. Adamiak

    2009-12-01

    Full Text Available Purpose: The aim of this work was to define and compare abrasion resistance of selected constructional materials widely used in the industry. Chromium cast iron wear resistant plates were compared with typically used wear resistant plates made from Hardox 400 steel and two different, wear resistant, materials cladded by welding technologies.Design/methodology/approach: The tests of abrasive wear were conducted in accordance to procedure “A” of standard ASTM G 65 - Standard Test Method for Measuring Abrasion Using the Dry Sand/Rubber Wheel Apparatus.Findings: Abrasion resistance tests shows that the best properties among investigated samples has chromium cast iron plate. Abrasion wear resistance of this plate is two times higher than wear resistance of layer made by welding technologies and nine times higher than typical Hardox 400 steel plate.Practical implications: Application, of abrasion resistant materials, results in significant material and economy savings, due to wear and costs reduction (decreasing stop times needed to change worn parts for a new one.Originality/value: Wear plates are modern solution in regeneration of worn machines parts and also for producing a new parts which connect high wear and abrasion resistance with costs reduction.

  15. Cervical Cancer Stage IA

    Science.gov (United States)

    ... historical Searches are case-insensitive Cervical Cancer Stage IA Add to My Pictures View /Download : Small: 720x576 ... Large: 3000x2400 View Download Title: Cervical Cancer Stage IA Description: Stage IA1 and IA2 cervical cancer; drawing ...

  16. CLINICOPATHOLOGICAL STUDY OF CERVICAL LYMPHADENOPATHY

    Directory of Open Access Journals (Sweden)

    Pradeep Kulal

    2015-07-01

    Full Text Available BACKGROUND AND OBJECTIVE : The analysis of lymph node enlargement in the neck is not a n easy task. It is challenge for surgeon to assess its clinical behaviour and come to a final diagnosis. These diseases which can be neoplastic also demands correct diagnosis for further management. The study intends to find out systematically the various p athological conditions presenting with enlarged lymph nodes in the neck, also various modes of clinical presentation and behaviour of these conditions. Relevant investigations have also been studied. METHODS AND MATERIALS : The study population consisted of patients above 12 years presenting with cervical lymph node enlargement. The material consists of patients during the period of January 2011 to J uly 2012. This study consists of 100 consecutive cases. Diagnosis is made on the basis of histopathological fi ndings. Patient was examined systemically giving utmost importance to local examination. After making a clinical diagnosis, further relevant investigations were done to confirm the diagnosis. Treatment was instituted appropriately and followed up the patie nts. RESULTS : Majority of the cases in this study had non - neoplastic causes for cervical lymphadenopathy in which tuberculosis is most common. Male and female ratio of 1.38:1 is noted with most cases between 12 and 30 years. Posterior triangle group of lym ph nodes was most commonly affected in tuberculosis. In lymphomas level 2 group of among the groups of lesions, with regard to local characteristics like number, laterality , mobility and involvement of other group of lymph nodes etc .FNAC by virtue of it being inexpensive, quick in getting results and easy to perform , is one of the important and essential diagnostic procedures. INTERPRETATION AND CONCLUSION : Clinical symptoms in cervical lymphadenopathy is of limited significance because clinical behaviour can be highly variable As cervical lymphadenopathy is an important disease, it always

  17. Papilomavírus humano e neoplasia cervical Human papillomavirus and cervical neoplasia

    Directory of Open Access Journals (Sweden)

    Maria Inês da Rosa

    2009-05-01

    Full Text Available O papilomavírus humano (HPV é um fator etiológico bem estabelecido para o câncer cervical. Esse vírus de DNA infecta primariamente o epitélio e pode induzir lesões benignas ou malignas na pele e na mucosa. Alguns HPVs são considerados de alto risco, responsáveis pela progressão das lesões precursoras até câncer cervical. A infecção genital pelo HPV é comum em mulheres jovens e geralmente é transitória. Uma pequena proporção de mulheres infectadas desenvolve câncer cervical, implicando o envolvimento de fatores ambientais e fatores genéticos na carcinogênese. Essa revisão aborda a estrutura viral, classificação e patologia do HPV, história natural e fatores de risco para neoplasia cervical e perspectivas futuras com a vacina anti-HPV.Human papillomavirus (HPV has been established as an important etiological factor for the development of cervical cancer. This DNA virus primarily infects the epithelium and can induce benign and malignant lesions of the mucous membranes and skin. Some HPVs are considered high risk due to their role in malignant progression of cervical tumors. Genital HPV infections are common and usually transient among young sexually active women. Only a small fraction of infected women develop cervical cancer, implying the involvement of environmental and genetic cofactors in cervical carcinogenesis. Classification, virology, pathology, natural history, epidemiological features of genital HPV infection, and future prospects for cervical cancer prevention with HPV vaccines will be reviewed here.

  18. Schwanomma From Cervical Sympathetic Chain Ganglion - A Rare Presentation.

    Science.gov (United States)

    Asma, A Affee; Kannah, E

    2015-10-01

    Schwanommas arising from cervical sympathetic chain are tumours that are rare in occurrence. These lesions are usually difficult to differentiate from a vagal schwanomma and a carotid body tumour during the initial workup. In this report, a rarely seen huge cervical sympathetic chain schwanomma case with partial Horner's syndrome is being presented in detail, which to our known knowledge, is one of the few cases reported in literature. PMID:26557566

  19. Some results of tangential turning with an abrasive water jet

    OpenAIRE

    Cárach, J.; Hlaváček, P.; K. Vasilko; Klich, J. (Jiří); S. Hloch

    2013-01-01

    This article deals with the visual comparison of the finished surface of sandstone using the tangential abrasive water jet. The continual abrasive water jet with turning was used with the constant pressure of 400 MPa for all sections of turning and with a depth of cut of 2mm. The abrasive particles were added to the water jet in the amount of 400 g.min-1. The traverse speed (vf = 60, 30, 10 mm.min-1) was gradually changing at a constant speed of rotation of workpiece n = 30min-1. Th...

  20. An Investigation of Different Material on Abrasive Water jet Machine

    OpenAIRE

    Vaibhav.j.limbachiya; Prof Dhaval.M.Patel

    2011-01-01

    Abrasive water jet machine (AWJM) is a nontraditional machining process. Abrasive water jet machining is a process of removal of material by impact erosion of high pressure (1500-4000 bar), high velocity of water and entrained high velocity of grit abrasives on a work piece. It’s a non-conventional machining process. At herefirst works on theoretical work after it make some experimental work and then analyses both results. Theoretical MRR found equal to the experimental MRR. In this paper inv...

  1. Effect of abrasive grit size on wear of manganese-zinc ferrite under three-body abrasion

    Science.gov (United States)

    Miyoshi, Kazuhisa

    1987-01-01

    Wear experiments were conducted using replication electron microscopy and reflection electron diffraction to study abrasion and deformed layers produced in single-crystal Mn-Zn ferrites under three-body abrasion. The abrasion mechanism of Mn-Zn ferrite changes drastically with the size of abrasive grits. With 15-micron (1000-mesh) SiC grits, abrasion of Mn-Zn ferrite is due principally to brittle fracture; while with 4- and 2-micron (4000- and 6000-mesh) SiC grits, abrasion is due to plastic deformation and fracture. Both microcracking and plastic flow produce polycrystalline states on the wear surfaces of single-crystal Mn-Zn ferrites. Coefficient of wear, total thickness of the deformed layers, and surface roughness of the wear surfaces increase markedly with an increase in abrasive grit size. The total thicknesses of the deformed layers are 3 microns for the ferrite abraded by 15-micron SiC, 0.9 microns for the ferrite abraded by 4-micron SiC, and 0.8 microns for the ferrite abraded by 1-micron SiC.

  2. New Rock Abrasivity Test Method for Tool Life Assessments on Hard Rock Tunnel Boring: The Rolling Indentation Abrasion Test (RIAT)

    Science.gov (United States)

    Macias, F. J.; Dahl, F.; Bruland, A.

    2016-05-01

    The tunnel boring machine (TBM) method has become widely used and is currently an important presence within the tunnelling industry. Large investments and high geological risk are involved using TBMs, and disc cutter consumption has a great influence on performance and cost, especially in hard rock conditions. Furthermore, reliable cutter life assessments facilitate the control of risk as well as avoiding delays and budget overruns. Since abrasive wear is the most common process affecting cutter consumption, good laboratory tests for rock abrasivity assessments are needed. A new abrasivity test method by rolling disc named Rolling Indentation Abrasion Test (RIAT) has been developed. The goal of the new test design and procedure is to reproduce wear behaviour on hard rock tunnel boring in a more realistic way than the traditionally used methods. Wear by rolling contact on intact rock samples is introduced and several rock types, covering a wide rock abrasiveness range, have been tested by RIAT. The RIAT procedure indicates a great ability of the testing method to assess abrasive wear on rolling discs. In addition and to evaluate the newly developed RIAT test method, a comprehensive laboratory testing programme including the most commonly used abrasivity test methods and the mineral composition were carried out. Relationships between the achieved results from conventional testing and RIAT results have been analysed.

  3. New Molecular Tools for Efficient Screening of Cervical Cancer

    Directory of Open Access Journals (Sweden)

    Magnus von Knebel Doeberitz

    2001-01-01

    Full Text Available Cytological screening using the Pap-smear led to a remarkable reduction of the mortality of cervical cancer. However, due to subjective test criteria it is hampered by poor inter- and intra-observer agreement. More reproducible assays are expected to improve the current screening and avoid unnecessary medical intervention and psychological distress for the affected women. Cervical cancer arises as consequence of persistent high risk papillomavirus (HR-HPV infections. Expression of two viral oncogenes, E6 and E7, in epithelial stem cells is required to initiate and maintain cervical carcinogenesis and results in significant overexpression of the cellular p16INK4a protein. Since this protein is not expressed in normal cervical squamous epithelia, screening for p16INK4a over-expressing cells allows to specifically identify dysplastic lesions, and significantly reduces the inter-observer disagreement of the conventional cytological or histological tests. Progression of preneoplastic lesions to invasive cancers is associated with extensive recombination of viral and cellular genomes which can be monitored by detection of papillomavirus oncogene transcripts (APOT assay derived from integrated viral genome copies. Detection of integrated type oncogene transcripts points to far advanced dysplasia or invasive cancers and thus represents a progression marker for cervical lesions. These new assays discussed here will help to improve current limitations in cervical cancer screening, diagnosis, and therapy control.

  4. Cervical computed tomography

    International Nuclear Information System (INIS)

    This book describes the possibilities of cervical computed tomography with the apparatus available at present. The normal anatomy of the cervical region as it appears in computed tomography is described with special regard to its compartimental structure and functional aspects; this is supplemented by anatomically normal measures obtained from cervical computed tomograms of 60 healthy individuals of different age and both sexes. The morphology of cervical anomalies obtained via CT and of the various acquired cervical disease processes is discussed and illustrated by means of the authors' own observations; the diagnostic value of the findings obtained by CT is discussed, a diagnosis is set up. (orig./MG)

  5. Abrasion Properties of Steel Fiber Reinforced Silica Fume Concrete According to Los Angeles and Water Abrasion Tests

    Directory of Open Access Journals (Sweden)

    Tsan-Ching CHENG

    2014-12-01

    Full Text Available The current study mainly investigated the influence of different tests on the abrasion resistance of concrete mixed with steel fibers and silica fume. The abrasion resistance was assessed at 28, 56 and 91 days on concretes with water-binder ratios of 0.35 and 0.55 where in some mixes silica fume was substituted by 5 % of cement by weight. Steel fibers of 0.5 % and 1.0 % of concrete volume were also added into the test concrete by replacement of coarse and fine aggregates. The results showed that concrete with higher compressive strength in Los Angeles abrasion tests also had better abrasion resistance. The inclusion of steel fibers into test concrete with a water-binder ratio of 0.35 resulted in a significant increase in compressive strength. This concrete also displayed better abrasion resistance and splitting tensile strength than reference concrete; in the test sample with a water-binder ratio of 0.55, the added steel fibers was unable to effectively produce cementation with the concrete. The inclusion of silica fume improved the abrasion resistance of concretes. In water abrasion testing, the abrasion resistance of concrete containing steel fiber was worse than that of concrete without steel fibers. In the water abrasion testing, the surface of steel fiber reinforced concrete was eroded by water and steel balls, and the impact caused the steel fibers to separate from the concrete and led to higher wear loss. DOI: http://dx.doi.org/10.5755/j01.ms.20.4.6460

  6. Relationships between radiography of cervical vertebrae and histopathology of the cervical cord in wobbling 19 foals

    International Nuclear Information System (INIS)

    Nineteen wobbling foals (17 males and 2 females) showing lameness of hindlimbs at 6 to 21 months of age were investigated radiographically and histopathologically. Minimum sagittal diameter (MSD), minimum flexion diameter (MFD) and minimum dural sagittal diameter (MDD) were measured on plain radiograms or myelograms taken at neutral and flexed positions as indicators of narrowed vertebral canal. After necropsy, the cervical spines and the spinal cord were examined macroscopically and respectively the relationships between radiographic findings and the corresponding morphological lesions were evaluated. Radiographically, lower values than each minimum reference limits were recorded in 14 foals in MSD, 5 foals in MFD and 6 foals in MDD, respectively. According to the histopathologic examination, the disappearance of axons and myelin sheaths, vacuolated spongy degeneration and appearance of macrophages were recognized symmetrically in the white matter of the cervical cord. These lesions were centrally located at the spinal cord radiographically demonstrated as compressed sites in 12 out of 17 foals examined. Macroscopically, asymmetrical overgrowth of one side of the process, encroachment of articular processes into the intervertebral foramina and proliferation of bone around articular facets were observed in the articular processes of bone specimens in the caudal neck of 6 foals. In conclusion, the equine incoordination might mainly be caused by the cervical stenotic myelopathy resulting from cervical vertebral malformation, and therefore the cervical vertebral radiography, especiallymyelography, is quite very important and effective for the diagnosis of wobbling foals

  7. Abrasions and lameness in piglets born in different farrowing systems with different types of floor

    Directory of Open Access Journals (Sweden)

    Mattsson Sigbrit

    2008-09-01

    Full Text Available Abstract Background The quality of the floor is essential to the welfare of piglets as abrasions often are recorded in newborn piglets, and such lesions may lead to lameness. Apart from animal suffering, lameness contributes to losses in form of dead piglets, decreased growth, and increased use of antibiotics and manual labour. Methods In a herd with three different farrowing systems, 37 litters (390 piglets were studied until the age of 3 weeks with respect to presence of skin wounds and abrasions. Lameness was registered until the age of 7 weeks. Eight lame piglets were sacrificed before medical treatment and subjected to necropsy including histopathological and microbiological examinations. Isolates of streptococci, staphylococci and E. coli were tested with respect to antimicrobial resistance. Mastitis was observed in ten sows. Results The most severe abrasions at carpus and soles were seen in the system with a new solid concrete floor with a slatted floor over the dunging area. The lowest magnitude was observed in the deep litter system with peat. Sole bruising was more common in the systems with concrete floor compared to the deep litter system with peat, and the differce in prevalence was significant at all examination days. The lesions decreased with time and about 75% of the treatments for lameness were performed during the first three weeks of life. The overall prevalence of lameness was highest in the system with new solid concrete floor with a slatted floor over the dunging area (9.4% followed by the old solid concrete floor (7.5%. A lower (p Conclusion There were large differences in the prevalence of abrasions and lameness between the floor types. The deep litter system with peat provided a soft and good floor for piglets. The overall prevalence of lameness was only diagnosed in every fourth litter in that system compared to in every second litter in the systems with concrete floor. In contrast, the incidence of mastitis in the

  8. Effect of the abrasive size and transformability degree on the two body abrasive wear of polycrystalline zirconia

    International Nuclear Information System (INIS)

    It was analyzed the two-body abrasive wear behavior of tetragonal zirconia polycrystals with different transformability degrees. The analyze was carried out in pin-on disk tests, by using different abrasive sizes and was complemented by monitoring the friction coefficient. The wear rate increased with the increasing of the abrasive size. The lowest transformability degree underwent the worst behavior on wear, probably associated with its low fracture toughness and the intermediate transformability presented the best behavior. The correlation between wear rate and friction coefficient characterized the presence of two distinct behaviors. (author). 14 refs., 3 figs

  9. Anterior cervical plating

    Directory of Open Access Journals (Sweden)

    Gonugunta V

    2005-01-01

    Full Text Available Although anterior cervical instrumentation was initially used in cervical trauma, because of obvious benefits, indications for its use have been expanded over time to degenerative cases as well as tumor and infection of the cervical spine. Along with a threefold increase in incidence of cervical fusion surgery, implant designs have evolved over the last three decades. Observation of graft subsidence and phenomenon of stress shielding led to the development of the new generation dynamic anterior cervical plating systems. Anterior cervical plating does not conclusively improve clinical outcome of the patients, but certainly enhances the efficacy of autograft and allograft fusion and lessens the rate of pseudoarthrosis and kyphosis after multilevel discectomy and fusions. A review of biomechanics, surgical technique, indications, complications and results of various anterior cervical plating systems is presented here to enable clinicians to select the appropriate construct design.

  10. A CAD System for Lesion Detection in Cervigram Based on Laws Textural Feature

    Directory of Open Access Journals (Sweden)

    RamaPraba P.S

    2014-01-01

    Full Text Available Cervical cancer is the second most common cancer among the women worldwide. A computer aided diagnosis system can help colposcopist to analyze cervical images more accurately. This work aims to detect lesion in cervical images based on Laws textural feature and nearest neighbor classifier and it can be used as a diagnostic tool. The images used for the detection of cervical cancer are taken by using colposcope which magnifies the cells of cervix. The Laws textural features are extracted from the cervical images and input to nearest neighbor classifier. A totally 240 images are used for the evaluation and an overall accuracy of 96% is obtained.

  11. Fractal Analysis of Cervical Intraepithelial Neoplasia

    Science.gov (United States)

    Fabrizii, Markus; Moinfar, Farid; Jelinek, Herbert F.; Karperien, Audrey; Ahammer, Helmut

    2014-01-01

    Introduction Cervical intraepithelial neoplasias (CIN) represent precursor lesions of cervical cancer. These neoplastic lesions are traditionally subdivided into three categories CIN 1, CIN 2, and CIN 3, using microscopical criteria. The relation between grades of cervical intraepithelial neoplasia (CIN) and its fractal dimension was investigated to establish a basis for an objective diagnosis using the method proposed. Methods Classical evaluation of the tissue samples was performed by an experienced gynecologic pathologist. Tissue samples were scanned and saved as digital images using Aperio scanner and software. After image segmentation the box counting method as well as multifractal methods were applied to determine the relation between fractal dimension and grades of CIN. A total of 46 images were used to compare the pathologist's neoplasia grades with the predicted groups obtained by fractal methods. Results Significant or highly significant differences between all grades of CIN could be found. The confusion matrix, comparing between pathologist's grading and predicted group by fractal methods showed a match of 87.1%. Multifractal spectra were able to differentiate between normal epithelium and low grade as well as high grade neoplasia. Conclusion Fractal dimension can be considered to be an objective parameter to grade cervical intraepithelial neoplasia. PMID:25302712

  12. Percutaneous vertebroplasty for eosinophilic granuloma of the cervical spine in a child

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Hua-Qiao; Li, Ming-Hua; Wu, Chun-Gen; Gu, Yi-Feng; Zhang, He; Fang, Chun [Shanghai Sixth People' s Hospital affiliated to Shanghai Jiao Tong University, Department of Radiology, Shanghai (China)

    2007-10-15

    We report a case of eosinophilic granuloma at the fourth cervical vertebra in a 10-year-old girl presenting with a 1-month history of cervical pain and stiffness. This lesion was histologically diagnosed by needle biopsy and then treated by percutaneous vertebroplasty. After the procedure, the cervical pain and stiffness resolved rapidly. The height of the vertebral body remained stable without further collapse over a 6-month follow-up period. (orig.)

  13. Cytological diagnosis of tuberculous cervicitis: A case report with review of literature

    OpenAIRE

    Kalyani, R; S R Sheela; M Rajini

    2012-01-01

    Tuberculosis of cervix is a rare disease. Tuberculosis usually affects women of childbearing age, indicating hormone dependence of infection. The patient presents with menstrual irregularities, infertility or vaginal discharge. Cervical lesions presents as papillary/vegetative growth or ulceration mimicking cervical cancer. Cervical Papanicolaou (Pap) smear plays an important role in diagnosing the disease by non-invasive technique in which the presence of epithelioid cells and Langhan′s type...

  14. The cytological diagnosis and prognosis of malignization of cervical epithelium of uterus in pregnant women.

    OpenAIRE

    Sumenko V.V.

    2007-01-01

    The investigation is dedicated to the study of the pathological alterations of cervical epithelium of uterus, proliferative activity in the lesion focuses and the improvement of cytological diagnosis of the state of cervical epithelium of uterus. The correlation between the proliferative processes in abnormal epithelium of uterine cervix and some pathological factors of the pregnant women organism was studied. The criteria for prognosis of the cervical epithelial dysplasia in pregnant women w...

  15. Horner´s Syndrome Post-Excision of a Huge Cervical Sympathetic Chain Schwannoma

    OpenAIRE

    Aydin, Sedat

    2007-01-01

    Schwannoma of the cervical sympathetic chain is a rare nerve tumor. These lesions typically present as an asymptomatic neck mass and are easily mistaken for a carotid body tumor during the initial work-up. In this report, a rarely seen huge cervical sympathetic chain schwannoma case, who experienced partial Horner´s syndrome postoperatively, is presented. We report a case of schwannoma on the cervical sympathetic chain, which to our knowledge is the largest reported in the current literature.

  16. Cervical degenerative intraspinal cyst: a case report and literature review involving 132 cases

    OpenAIRE

    Machino, Masaaki; YUKAWA, YASUTSUGU; ITO, KEIGO; KATO, FUMIHIKO

    2012-01-01

    Intraspinal and extradural cysts in the cervical spine are rare disorders that may cause myelopathy or radiculopathy. A synovial cyst or ganglion derived from the facet joint and that from a ligamentum flavum have been reported. We report a surgical case of degenerative intraspinal cyst, causing cervical myelopathy. MRI of a case revealed cystic lesion at C4–5. Spinal cord was compressed by cyst and symptoms of myelopathy were also observed. The patient with cervical spinal canal stenosis und...

  17. Anti-abrasive nanocoatings current and future applications

    CERN Document Server

    2015-01-01

    This book provides an overview of the fabrication methods for anti-abrasive nanocoatings. The connections among fabrication parameters, the characteristics of nanocoatings and the resulting properties (i.e. nanohardness, toughness, wear rate, load-bearing ability, friction coefficient, and scratch resistance) are discussed. Size-affected mechanical properties of nanocoatings are examined, including their uses. Anti-abrasive nanocoatings, including metallic-, ceramic-, and polymeric-based layers, as well as different kinds of nanostructures, such as multi-layered nanocomposites and thin films, are reviewed. * Provides a comprehensive overview of the fabrication methods for anti-abrasive nanocoatings* Discusses the connections among fabrication parameters, the characteristics of nanocoatings and the resulting properties* Reviews advantages and drawbacks of fabrication methods for anti-abrasive nanocoatings and clarifies the place of these nanocoatings in the world of nanotechnology

  18. An Investigation of Different Material on Abrasive Water jet Machine

    Directory of Open Access Journals (Sweden)

    Vaibhav.j.limbachiya

    2011-07-01

    Full Text Available Abrasive water jet machine (AWJM is a nontraditional machining process. Abrasive water jet machining is a process of removal of material by impact erosion of high pressure (1500-4000 bar, high velocity of water and entrained high velocity of grit abrasives on a work piece. It’s a non-conventional machining process. At herefirst works on theoretical work after it make some experimental work and then analyses both results. Theoretical MRR found equal to the experimental MRR. In this paper investigation for three different materials like en8,acrylic and aluminum is carried out using Taguchi design of experiment method. Experiments are carried out using L25 Orthogonal array by varying Material traverse speed and abrasive mass flow rate for each material respectively. Anova carried out for identifies significant parameters.

  19. Refractory, Abrasive, and Other Industrial Minerals Operations - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This map layer includes refractory, abrasive, and other industrial minerals operations in the United States. The data represent commodities covered by the Minerals...

  20. Hardness and elasticity of abrasive particles measured by instrumented indentation

    OpenAIRE

    Hvizdoš, P.

    2015-01-01

    Basic mechanical properties of seven types (from seven different sites) of abrasive garnet particles used for water jet cutting were measured using the technique of instrumented indentation (also called depth sensing indentation or nanoindentation). Hardness and modulus of elasticity were evaluated and compared. All the abrasives had similar measured mechanical properties (hardness 20 – 24.16 GPa), the highest values were found for the Czech garnet.

  1. A review of micro-scale abrasion testing

    International Nuclear Information System (INIS)

    Micro-scale abrasion (commonly referred to as 'ball cratering') is a small-scale tribological test method which can be operated on a desktop. It offers the possibility of providing a quick, cheap, localized abrasion test that can be used with small samples. In principle its operation is simple, but in practice there are issues with wear scar measurement, wear mode and its applicability to a wide variety of monolithic materials and coatings. (topical review)

  2. Computed tomography to quantify tooth abrasion

    Science.gov (United States)

    Kofmehl, Lukas; Schulz, Georg; Deyhle, Hans; Filippi, Andreas; Hotz, Gerhard; Berndt-Dagassan, Dorothea; Kramis, Simon; Beckmann, Felix; Müller, Bert

    2010-09-01

    Cone-beam computed tomography, also termed digital volume tomography, has become a standard technique in dentistry, allowing for fast 3D jaw imaging including denture at moderate spatial resolution. More detailed X-ray images of restricted volumes for post-mortem studies in dental anthropology are obtained by means of micro computed tomography. The present study evaluates the impact of the pipe smoking wear on teeth morphology comparing the abraded tooth with its contra-lateral counterpart. A set of 60 teeth, loose or anchored in the jaw, from 12 dentitions have been analyzed. After the two contra-lateral teeth were scanned, one dataset has been mirrored before the two datasets were registered using affine and rigid registration algorithms. Rigid registration provides three translational and three rotational parameters to maximize the overlap of two rigid bodies. For the affine registration, three scaling factors are incorporated. Within the present investigation, affine and rigid registrations yield comparable values. The restriction to the six parameters of the rigid registration is not a limitation. The differences in size and shape between the tooth and its contra-lateral counterpart generally exhibit only a few percent in the non-abraded volume, validating that the contralateral tooth is a reasonable approximation to quantify, for example, the volume loss as the result of long-term clay pipe smoking. Therefore, this approach allows quantifying the impact of the pipe abrasion on the internal tooth morphology including root canal, dentin, and enamel volumes.

  3. Cervical sympathetic chain schwannoma: a case report

    OpenAIRE

    Inès Nacef; Skander Kedous; Zied Attia; Slim Touati; Said Gritli

    2012-01-01

    Nerve tumors arising from the sympathetic chain are uncommon slow-growing tumors and represent a diagnosis challenge. Their malignant degeneration is rare. Definitive pre-operative diagnosis may be difficult as investigations are not usually helpful. We report the case of a 23-year old woman who presented with an asymptomatic solitary left cervical swelling. She was evaluated with sonography and computed tomography. Complete surgical excision of the lesion was carried out and histologic exami...

  4. Cervical cancer: Can it be prevented?

    OpenAIRE

    Aggarwal, Pakhee

    2014-01-01

    Cervical cancer prevention requires a multipronged approach involving primary, secondary and tertiary prevention. The key element under primary prevention is human papilloma virus (HPV) vaccination. So far, only prophylactic HPV vaccines which prevent HPV infection by one or more subtypes are commercially available. Therapeutic HPV vaccines which aid in clearing established infection are still under trial. Secondary prevention entails early detection of precancerous lesions and its success is...

  5. Frequencies and role of regulatory T cells in patients with (pre)malignant cervical neoplasia

    NARCIS (Netherlands)

    Visser, J.; Nijman, H. W.; Hoogenboom, B.-N.; Jager, P.; van Baarle, D.; Schuuring, E.; Abdulahad, W.; Miedema, F.; van der Zee, A. G.; Daemen, T.

    2007-01-01

    Oncogenic human papillomavirus (HPV)-infection is crucial for developing cervical cancer and its precursor lesions [cervical intraepithelial neoplasia (CIN)]. Regulatory T cells (T-regs) might be involved in the failure of the immune system to control the development of HPV-induced cancer. We invest

  6. Automated identification of diploid reference cells in cervical smears using image analysis.

    NARCIS (Netherlands)

    Laak, J.A.W.M. van der; Siebers, A.G.; Cuijpers, V.M.J.I.; Pahlplatz, M.M.M.; Wilde, P.C.M. de; Hanselaar, A.G.J.M.

    2002-01-01

    BACKGROUND: Acquisition of DNA ploidy histograms by image analysis may yield important information regarding the behavior of premalignant cervical lesions. Accurate selection of nuclei for DNA measurement is an important prerequisite for obtaining reliable data. Traditionally, manual selection of nu

  7. Cervical Microbiome and Cytokine Profile at Various Stages of Cervical Cancer: A Pilot Study

    Science.gov (United States)

    Bahena-Román, Margarita; Téllez-Sosa, Juan; Martínez-Barnetche, Jesús; Cortina-Ceballos, Bernardo; López-Estrada, Guillermina; Delgado-Romero, Karina; Burguete-García, Ana I.; Cantú, David; García-Carrancá, Alejandro; Madrid-Marina, Vicente

    2016-01-01

    Cervical cancer (CC) is caused by high-risk human papillomavirus persistence due to the immunosuppressive tumor microenvironment mediated by cytokines. Vaginal microbiota determines the presence of certain cytokines locally. We assessed the association between cervical microbiota diversity and the histopathological diagnosis of each stage of CC, and we evaluated mRNA cervical expression levels of IL-4, IL-6, IL-10, TGF-β1, TNF-α and IFN-γ across the histopathological diagnosis and specific bacterial clusters. We determined the cervical microbiota by high throughput sequencing of 16S rDNA amplicons and classified it in community state types (CST). Mean difference analyses between alpha-diversity and histopathological diagnosis were carried out, as well as a β-diversity analysis within the histological diagnosis. Cervical cytokine mRNA expression was analyzed across the CSTs and the histopathological diagnoses. We found a significant difference in microbiota's diversity in NCL-HPV negative women vs those with squamous intraepithelial lesions (SIL) and CC(p = 0.006, p = 0.036).When β-diversity was evaluated, the CC samples showed the highest variation within groups (p<0.0006) and the largest distance compared to NCL-HPV negative ones (p<0.00001). The predominant bacteria in women with normal cytology were L. crispatus and L. iners, whereas for SIL, it was Sneathia spp. and for CC, Fusobacterium spp. We found higher median cervical levels of IL-4 and TGF-β1 mRNA in the CST dominated by Fusobacterium spp. These results suggest that the cervical microbiota may be implicated in cervical cancer pathology. Further cohort studies are needed to validate these findings. PMID:27115350

  8. Get Tested for Cervical Cancer

    Science.gov (United States)

    ... Cervical Cancer Print This Topic En español Get Tested for Cervical Cancer Browse Sections The Basics Overview ... be cured. How often should I get screened (tested)? How often you should get screened for cervical ...

  9. Cervical cancer - screening and prevention

    Science.gov (United States)

    Cancer cervix - screening; HPV - cervical cancer screening; Dysplasia - cervical cancer screening ... Almost all cervical cancers are caused by HPV (human papilloma virus). HPV is a common virus that spreads through sexual contact. Certain ...

  10. Treatment Option Overview (Cervical Cancer)

    Science.gov (United States)

    ... Cancer Prevention Cervical Cancer Screening Research Cervical Cancer Treatment (PDQ®)–Patient Version General Information About Cervical Cancer ... Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery) depends on ...

  11. Acupoints for cervical spondylosis

    OpenAIRE

    Zhu, Jihe; Arsovska, Blagica; Vasileva, Dance; Petkovska, Sofija; Kozovska, Kristina

    2015-01-01

    Cervical spondylosis is a chronic degenerative condition of the cervical spine that affects the vertebral bodies and intervertebral disks of the neck, as well as the contents of the spinal canal. This is one of the most common degenerative disorders of the spine. The disease can be symptomatic and asymptomatic. Symptoms that are distinctive for cervical spondylosis are: tingling, numbness and weakness in the limbs, lack of coordination, stiff neck, shoulder pain, occipital pain, vertigo, poor...

  12. Tuina treatment in cervical spondylosis

    OpenAIRE

    Florin Mihai Hinoveanu

    2010-01-01

    Cervical spondylosis is a common, chronic degenerative condition of the cervical spine that affects the vertebral bodies and intervertebral disks of the neck as well as the contents of the spinal canal. Common clinical syndromes associated with cervical spondylosis include cervical pain, cervical radiculopathy and/or mielopathy. This study show the main principles, indication and side effects of tuina in cervical spondylosis´ treatment; tuina is one of the external methods based on the princ...

  13. Genotype detection analysis of cervical lesions in patients with human papillomavirus in Luliang City%吕梁地区宫颈病变患者人乳头状瘤病毒基因型的检测分析

    Institute of Scientific and Technical Information of China (English)

    常新剑

    2012-01-01

    目的 调查吕梁地区21种人乳头状瘤病毒基因型的检测分析.方法 收集568例女性宫颈病变患者宫颈分泌物中的脱落细胞,应用人乳头状瘤病毒导流杂交快速基因分型技术检测21种人乳头状瘤病毒亚型,包括13种高危亚型(16,18,31,33,35,39,45,51,52,56,58,59和68型)、5种低危亚型(6,11,42,43和44型)和3种中国人群常见亚型(53,66和CP8304型);分析21种基因型的流行病学特征.结果 人乳头状瘤病毒感染率41.9%,单一感染率58.4%,混合性感染率39.9%.21种基因型中,高危型以16,53型为主,其次是52,58型,低危型以6,11型为主;人乳头状瘤病毒16型的感染率居首位.结论 本地区21种人乳头状瘤病毒基因型的检测分析资料对人乳头状瘤病毒疫苗研究、应用及其感染的防治有重要意义.%Objective: To investigate the molecular epidemiologic characteristics of 21 genotypes of human papillomavirus in women with cervical disease in LuLJang. Methods; A total of 568 samples were collected from female patients with cervical disease in Henan. Twenty - one genotypes of human papillomavirus were tested by hybrid Max, and studied the molecular epidemiologic characteristics of human papillomavirus subtypes, including 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 6, 11, 42, 43, 44, 53, 66, and CP8304. Results; The total positive rate of 21 genotypes of human papillomaviruswas 41. 9% . The positiverate was 58. 4% of single human papillomavirus genotypes, and 39. 9% of mixed infection. Among 21 genotypes of human papillomavirus, the main high - risk genotypes were human papillomavirus 16 and 53, and low - risk genotypes were 6 and 11. The infectious rate of human papillomavirus 16 ranked first. Conclusion; The information on the molecular epidemiology of human papillomavirus would play an important role in the study and application of vaccine, and in the prevention and therapy of human papillomavirus infection.

  14. Short-term risk of cervical intraepithelial neoplasia grades 2 and 3 for women with normal cytology and human papillomavirus infection Riesgo a corto plazo de lesiones intraepiteliales cervicales grados 2 y 3 en mujeres con citología vaginal normal e infección por el virus del papiloma humano

    Directory of Open Access Journals (Sweden)

    Gustavo Hernández-Suárez

    2010-12-01

    Full Text Available OBJECTIVE. To assess the risk of cervical intraepithelial neoplasia grades 2, 3 or higher (CIN 2/3+ for women with normal cytology and concurrent high-risk human papillomavirus infection (HR-HPV. MATERIAL AND METHODS. We examined 2 200 women every 6 months for an average of 9 years. Cervical smears and samples for HPV DNA were obtained at each visit. Absolute risk of subsequent CIN2/CIN3+ was estimated using the Kaplan-Meier method. RESULTS. The absolute risk of CIN2/CIN3+ among HR-HPV-positive women with normal Pap smear results was 1.06% (95%CI, 0.57-2.20, 5 times higher the risk among all women with normal Pap smears (0.20%; 95%CI, 0.12-0.32 but 7 times lower than that for women with HR-HPV infection and LSIL (7.24%; 95%CI, 3.78-15.2. CONCLUSION. Short-term absolute risk of CIN2/3+ after a normal Pap smear with concurrent HR-HPV infection is low (~1%, suggesting that the HR-HPV test has limited utility in short-term clinical decision-making for women with normal cytology.OBJETIVO. Evaluar el riesgo a corto plazo de neoplasia intraepitelial cervical de alto grado (CIN2/CIN3+ en mujeres con citologí-a cervicouterina normal e infección por virus del papiloma humano de alto riesgo (HR-HPV. MATERIAL Y MÉTODOS. Cohorte prospectiva de 2200 mujeres evaluadas cada seis meses durante 9 años en promedio. En cada visita se tomó muestra cervical para extendido y detección de HPV DNA. El riesgo absoluto de CIN2/CIN3+ a la siguiente visita fue calculado utilizando el método de Kaplan-Meier. RESULTADOS. En mujeres con citologí-a normal e infección concomitante por HR-HPV el riesgo absoluto de presentar CIN2/CIN3+ fue de 1.06% (95%CI, 0.57-2.20. Este riesgo fue cinco veces mayor al observado en todas las mujeres con citologí-a normal (0.20%; 95%CI, 0.12-0.32 pero siete veces menor que el observado en mujeres con lesiones intraepiteliales escamosas de bajo grado con infección concomitante (7.24%; 95%CI, 3.78-15.2. CONCLUSIÓN. El riesgo absoluto de

  15. Methods of diagnosis in cervical neoplasia

    Directory of Open Access Journals (Sweden)

    Mariana Bratu

    2010-06-01

    Full Text Available The early screening of a precancerous lesion that can develop spontaneously into a cancerous lesion thatis first non-invasive and then invasive. Materials and methods. The study group was made of 1485 patients who were hospitalized between 2001 and 2009 in the Section of Obstetrics and Gynecology of ?Sf. Apostol Andrei? Emergency Hospital in Gala?i. The patients filled in a questionnaire on a sheet of paper in a freely consented way and they were diagnosed with cervical cancer by a cytologic and colposcopic examination, biopsy and other complementary examinations. Results and discussions. It is obvious that, even if cervical carcinoma benefits now from a remarkable methodology of detecting the early forms and even the precursor lesions, in our country this lesion has an importantfrequency and even represents a public health issue with important social-economic implications; in most cases it affects people in full physical and procreative activity; it implies a laborious therapy, long time hospitalization and high costs. The risk of getting infected with HPV(human papilloma virus is at least 50% for the sexually active people for the rest of their lives. Although most infections eliminate with the help of our own immunity, the people who are infected are not aware of HPV presence and they can spread the virus. When our own immune system cannot eliminate the infection, thepersistence of the viral oncogenic strains from the cervical mucosa can lead to the appearance of precancerous lesions.The cytological examination is a simple and fast method that is also cheap and reliable being considered the mosteffective technique for preventing and detecting the precancerous conditions of the cervix, which, treated correctly, canoffer a primary prevention of cervical cancer. The diagnostic certainty was accomplished exclusively by histopathologyof the material obtained during biopsy. Conclusions. We consider that the patients with cervical cancer, no matter

  16. Cervical cancer: Can it be prevented?

    Science.gov (United States)

    Aggarwal, Pakhee

    2014-10-10

    Cervical cancer prevention requires a multipronged approach involving primary, secondary and tertiary prevention. The key element under primary prevention is human papilloma virus (HPV) vaccination. So far, only prophylactic HPV vaccines which prevent HPV infection by one or more subtypes are commercially available. Therapeutic HPV vaccines which aid in clearing established infection are still under trial. Secondary prevention entails early detection of precancerous lesions and its success is determined by the population coverage and the efficacy of the screening technique. A number of techniques are in use, including cytology, visual inspection (using the naked eye, magnivisualizer, acetic acid and Lugol's iodine), HPV testing and a combination of these methods. Updated screening guidelines have been advocated by the American Cancer Society in light of the role of HPV on cervical carcinogenesis. Recent research has also focussed on novel biomarkers that can predict progression to cancer in screen positive women and help to differentiate those who need treatment from those who can be left for follow-up. Last but not the least, effective treatment of precancerous lesions can help to reduce the incidence of invasive cervical cancer and this constitutes tertiary prevention. A combination of these approaches can help to prevent the burden of cervical cancer and its antecedent morbidity and mortality, but all of these are not feasible in all settings due to resource and allocation constraints. Thus, all countries, especially low and middle income ones, have to determine their own cocktail of approaches that work before we can say with certainty that yes, cervical cancer can be prevented. PMID:25302177

  17. Association of traffic-related hazardous air pollutants and cervical dysplasia in an urban multiethnic population: a cross-sectional study

    OpenAIRE

    Scheurer, Michael E.; Danysh, Heather E.; Follen, Michele; Philip J Lupo

    2014-01-01

    Background Human papillomavirus (HPV) infection is a necessary cause in the development of cervical cancer; however, not all women infected with HPV develop cervical cancer indicating that other risk factors are involved. Our objective was to determine the association between exposure to ambient levels of common traffic-related air toxics and cervical dysplasia, a precursor lesion for cervical cancer. Methods The study sample consisted of women enrolled in a Phase II clinical trial to evaluat...

  18. Comparative pulmonary toxicity of 6 abrasive blasting agents

    Energy Technology Data Exchange (ETDEWEB)

    Hubbs, A.F.; Minhas, N.S.; Jones, W.; Greskevitch, M.; Battelli, L.A.; Porter, D.W.; Goldsmith, W.T.; Frazer, D.; Landsittel, D.P.; Ma, J.Y.C.; Barger, M.; Hill, K.; Schwegler-Berry, D.; Robinson, V.A.; Castranova, V. [Center for Disease Control and Prevention, Morgantown, WV (USA). Health Effects Laboratory Division

    2001-05-01

    Inhalation of silica dust is associated with pulmonary fibrosis, Therefore, substitute abrasive materials have been suggested for use in abrasive blasting operations. To date, toxicological evaluation of most substitute abrasives has been incomplete. Therefore, the objective of this study was to compare the pulmonary toxicity of a set of substitute abrasives (garnet, staurolite, coal slag, specular hematite, and treated sand) to that of blasting sand. Rats were exposed to blasting sand or an abrasive substitute by intratracheal instillation and pulmonary responses to exposure were monitored 4 weeks postexposure. Pulmonary damage was monitored as lactate dehydrogenase (LDH) in the acellular lavage fluid. Pulmonary inflammation was evaluated from the yield of polymorphonuclear leukocytes (PMN) obtained by bronchoalveolar lavage. The activity of alveolar macrophages was determined by measuring: zymosan-stimulated chemiluminescence. Blasting sand caused lung damage and showed histologic evidence for inflammation and fibrosis, Garnet, staurolite, and treated sand exhibited toxicity and inflammation that were similar to blasting sand. while coal slag caused greater pulmonary damage and inflammation than blasting sand, In contrast, specular hematite did not significantly elevate LDH or PMN levels and did not stimulate macrophage activity 4 weeks postexposure.

  19. Abrasive supply for ancient Egypt revealed

    International Nuclear Information System (INIS)

    In the framework of the major research scheme 'Synchronization of Civilizations in the Eastern Mediterranean Region in the 2nd Millennium B.C' instrumental neutron activation analysis (INAA) was used to determine 30 elements in pumice from archaeological excavations to reveal their specific volcanic origin. In ancient time, the widespread pumiceous products of several eruptions in the Aegean region have been used as abrasive tools and were therefore popular trade objects. The correlation of such archaeological findings to a specific eruption of known age would therefore allow to certify a maximum age of the respective stratum ('dating by first appearance'). Pumices from the Aegean region can easily be distinguished by their trace element distribution patterns. This has been shown by previous studies of the group. The elements Al, Ba, Ca, Ce, Co, Cr, Cs, Dy, Eu, Fe, Hf, K, La, Lu, Mn, Na, Nd, Rb, Sb, Sc, Sm, Ta, Tb, Th, Ti, U, V, Yb, Zr and Zn were determined in 16 samples of pumice lumps from excavations in Tell-el-Dab'a and Tell-el-Herr (Egypt). Two irradiation cycles and five measurement runs were applied. To show the accuracy of the results obtained, typical samples of the most important pumice sources in the Aegean region, particularly from Milos, Nisyros, Kos and Thera were analyzed together with the Egyptian samples of unknown origin. A reliable identification of the samples is achieved by comparing these results to the database compiled in previous studies. The geographical positions of these islands are shown. Within the error range, most of the elements determined in typical representatives of Milos, Nisyros, Kos and Santorini were in perfect agreement with values from the literature. On the basis of the Cluster graphics presented, it is possible to relate unknown pumice to its primary source, just by comparing the relation of a few elements, like Ta-Eu and Th-Hf. One concludes that all samples except one can be related to the Minoan eruption of Thera

  20. Detention of HPV L1 Capsid Protein and hTERC Gene in Screening of Cervical Cancer

    Directory of Open Access Journals (Sweden)

    Huang Bin

    2013-06-01

    Full Text Available   Objective(s: To investigate the expression of human papilloma virus (HPV L1 capsid protein, and human telomerase RNA component (hTERC in cervical cancer and the role of detection of both genes in screening of cervical cancer.   Materials and Methods: A total of 309 patients were recruited and cervical exfoliated cells were collected. Immunocytochemistry was employed to detect HPV L1 capsid protein, and fluorescent in situ hybridization (FISH was performed to detect the hTERC. Results: The expression of HPV L1 capsid protein reduced with the increase of the histological grade of cervical cells and was negatively related to the grade of cervical lesions. However, the expression of hTERC increased with the increase of the histological grade and positively associated with the grade of cervical lesions. The proportion of patients with L1(-/hTERC(+ was higher in patients with histological grade of CIN2 or higher than that in those with histological grade of CIN1. The L1(+/hTERC(- and L1(-/hTERC(- were negatively related to the grade of cervical lesions. L1(-/hTERC(+ was positively associated with the grade of cervical lesions. The L1/hTERC ratio increased. The negative predictive value of both HPV L1 and hTERC was higher than that of HPV L1 or hTERC, but there was no marked difference in the screening efficacy of cervical cancer among HPV L1, hTERC and HPV L1+hTERC. Conclusion: HPV L1 capsid protein and hTERC gene may serve as markers for the early diagnosis and prediction of cervical lesions. The increase in L1/hTERC ratio reflects the progression of cervical lesions to a certain extent.

  1. The diameters of the cervical spinal cord shown by Amipaque-myelography

    International Nuclear Information System (INIS)

    The sagittal and cross diameters of the cervical spinal cord were measured in 53 patients with cervical nerve root compression and with no evidence of spinal cord involvement, as well as in 45 patients with spastic tetraparesis and no localised space occupying lesion, and 29 patients with myelographically proven cervical myelography. The true diameters were calculated by the known magnification factor (1:1,4). Patients with spastic tetraparesis showed diameters in normal ranges, as well as widened or diminished sizes of the cord. Some of the patients with cervical myelopathy showed diminished diameters in the caudal parts. This may be a hint for a poor outcome after decompression operation. (orig.)

  2. Radiologic Findings of Cervical Varix Developed in Late Pregnancy: Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Young Chan; Kim, Ho Kyun [Catholic University of Daegu College of Medicine, Daegu (Korea, Republic of)

    2006-12-15

    Cervical varix is a rare cause of obstetric hemorrhage which needs accurate diagnosis and prompt management because the lesion may be associated with preterm delivery and maternal complications. Our patient was diagnosed with cervical varix and vaginal bleeding at 32 weeks' gestation, using trans vaginal ultrasound and MRI. Persistent vaginal bleeding and preterm labor led to an emergency cesarean section at 33 weeks' gestation. After delivery, cervical varix was spontaneously resolved in the follow-up trans vaginal ultrasound and CT. We report various radiologic features of cervical varix combined with vaginal bleeding in late pregnancy

  3. Study of abrasive resistance of composites for dental restoration by ball-cratering

    OpenAIRE

    Antunes, P. Vale; Ramalho, A

    2003-01-01

    Two-body abrasion occurs in the mouth whenever there is tooth-to-tooth contact. This is what most dentists call attrition. Abrasive wear may also occur when there is an abrasive slurry interposed between two surfaces, such that the two solid surfaces are not actually in contact, this is called three-body abrasion, with food acting as the abrasive agent, and occurs in the mouth during mastication. Abrasion is the key physiological wear mechanism that is present in dental materials during norma...

  4. Contribuição ao estudo da microinfiltração in vitro de lesões cervicais não cariosas restauradas com diferentes materiais adesivos e técnicas In vitro evaluation of microleakage of noncarious cervical lesions restored with different adhesive materials and techniques

    Directory of Open Access Journals (Sweden)

    Adriana Bona MATOS

    1997-01-01

    Full Text Available A restauração de lesões cervicais não cariosas é um procedimento comum na clínica diária, havendo uma alta incidência de casos de perda da restauração, descoloração marginal e recidiva de cárie. A etiologia desse tipo de lesão é considerada multifatorial. Neste trabalho, avaliou-se a microinfiltração diante das seguintes variáveis: tipo de material utilizado (dois adesivos de quarta geração utilizados em conjunto com duas resinas compostas de tipos diferentes, ©microfillª e híbrida, dois métodos de polimerização dos sistemas adesivos (foto e dual e duas técnicas restauradoras (incremental e do incremento único. Na metodologia deste trabalho, utilizaram-se ciclagem térmica e mecânica, técnica de infiltração com nitrato de prata, cortes seriados e leitura dos resultados através de escala de escores. A microinfiltração foi menor quando se utilizou uma resina composta híbrida comparada à resina ©microfillª. Ao se utilizar o método de polimerização dual do sistema adesivo, a microinfiltração foi menor do que com o método somente fotopolimerizável. A técnica restauradora não exerceu influência sobre o padrão de microinfiltração encontrado nas restaurações de lesões cervicais não cariosasRestoration of noncarious cervical lesions is a usual clinical procedure, and there is a high incidence of restoration loss, marginal discoloration, and recurrent caries. All the factors that play an important role in this process have to be considered when studying this kind of lesion of complex multifactorial etiology. Microleakage was evaluated related to the type of material used (two fourth generation bonding systems used with two types of composite resins: hybrid and microfill, two polymerization methods for bonding systems (photo and dual cure and two restorative techniques (incremental and bulk. This study used thermal and mechanical cycling procedures, infiltration tests with silver nitrate solution

  5. Cervical celullitis in broiler chickens for Escherichia coli/
    Celulite cervical em frangos de corte causada por Escherichia coli

    OpenAIRE

    Ivens Gomes Guimarães; Milene Martins Berbel; Marcia Marinho Luzardo; Werner Okano; Claudia Yurika Tamehiro; Benito Guimarães de Brito

    2002-01-01

    In this paper was report the isolation of Escherichia coli in broiler chickens with cellulitis in the cervical region. It was carried through the isolation of E. coli of the lesion of cellulitis from broilers and carried through histopathological examination of skin that had characterized the lesion. Focal ulcerations of epidermis, fibrin in dermis and difuse infiltrated by lymphocytes and heterophils on subcutaneous tissues.Neste trabalho, relata-se o isolamento de Escherichia coli em frango...

  6. A radiological study on the cervical spine in rheumatoid arthritis

    Energy Technology Data Exchange (ETDEWEB)

    Taketomi, Eiji; Sakoh, Takashi; Sunahara, Nobuhiko [Kagoshima Univ. (Japan). Faculty of Medicine

    1995-03-01

    The cervical spine was examined with the magnetic resonance imaging (MRI) and the conventional roentgenograms in 95 patients with rheumatoid arthritis. The MRI findings of upper cervical disorders were compared with various values determined in roentgenograms: the atlanto-dental interval (ADI), the space available for the spinal cord (SAC), and the Ranawat and Redlund-Johnell values. In patients with vertical setting (VS), MRI showed medullary compression in all those with abnormal Redlund-Johnell values and Ranawat values of 7 mm or less. In patients with anterior atlanto-axial subluxation, compression of the upper cervical cord was observed in all patients with SAC of 13 mm or less. In subaxial lesion of the cervical spine, MRI was found to be as good as roentgenograms in evaluating plate erosion and disc space narrowing and MRI showed extradural pannus. (author).

  7. CDC's Cervical Cancer Study

    Science.gov (United States)

    ... in Cancer Moonshot Stay Informed CDC’s Cervical Cancer Study Language: English Español (Spanish) Recommend on Facebook Tweet ... year. As part of CDC’s Cervical Cancer (Cx3) Study, we surveyed a sample of both health care ...

  8. Prepolishing on a CNC platform with bound abrasive contour tools

    Science.gov (United States)

    Schoeffler, Adrienne E.; Gregg, Leslie L.; Schoen, John M.; Fess, Edward M.; Hakiel, Michael; Jacobs, Stephen D.

    2003-05-01

    Deterministic microgrinding (DMG) of optical glasses and ceramics is the commercial manufacturing process of choice to shape glass surfaces prior to final finishing. This process employs rigid bound matrix diamond tooling resulting in surface roughness values of 3-5μm peak to valley and 100-400nm rms, as well as mid-spatial frequency tool marks that require subsequent removal in secondary finishing steps. The ability to pre-polish optical surfaces within the grinding platform would reduce final finishing process times. Bound abrasive contour wheels containing cerium oxide, alumina or zirconia abrasives were constructed with an epoxy matrix. The effects of abrasive type, composition, and erosion promoters were examined for tool hardness (Shore D), and tested with commercial optical glasses in an Optipro CNC grinding platform. Metrology protocols were developed to examine tool wear and subsequent surface roughness. Work is directed to demonstrating effective material removal, improved surface roughness and cutter mark removal.

  9. Comminution of Mica by Cavitation Abrasive Water Jet

    Institute of Scientific and Technical Information of China (English)

    GUO Chu-wen; LIU Lin-sheng; HAN Dong-tai; LI Ai-min; ZHANG Dong-hai

    2003-01-01

    The comminution of mica with an abrasive water jet is mainly based on three knids of effects, that is, high-speed collision, cavitating effect and shearing effect. Cavitation abrasive water jet was applied for the comminution of mica because cavitation abrasive water jet can make full use of the three effects mentioned above. Besides high speed impacting among particles,cavitation and shearing were also enhanced due to the divergent angle at the outlet of the cavitation nozzle.A JME-200CX transmission electron microscope was used for observing the size distribution of particles.Variance analysis on the experimental results indicates that the effect of cavitation is much more significant than that of collision.The effect of pressure on comminution results becomes less with the decrease of the particle size.

  10. Molecular Mechanism and Potential Targets for Blocking HPV-Induced Lesion Development

    OpenAIRE

    Madrid-Marina, V.; K. Torres-Poveda; Peralta-Zaragoza, O.; V. H. Bermúdez-Morales; E. Guzmán-Olea

    2011-01-01

    Persistent infection with high-risk HPV is the etiologic agent associated with the development of cervical cancer (CC) development. However, environmental, social, epidemiological, genetic, and host factors may have a joint influence on the risk of disease progression. Cervical lesions caused by HPV infection can be removed naturally by the host immune response and only a small percentage may progress to cancer; thus, the immune response is essential for the control of precursor lesions and C...

  11. European guidelines for quality assurance in cervical histopathology

    NARCIS (Netherlands)

    Bulten, J.; Horvat, R.; Jordan, J.; Herbert, A.; Wiener, H.; Arbyn, M.

    2011-01-01

    The current paper presents Chapter 5 of the second edition of the European Guidelines for Quality Assurance in Cervical Cancer Screening, which deals with the histopathological diagnosis of lesions of the uterine cervix. It completes a series of publications in journals containing the contents of ot

  12. Cytological patterns of cervical pap smears with histopathological correlation

    Directory of Open Access Journals (Sweden)

    Bhagya Lakshmi Atla

    2015-08-01

    Conclusion: Pap smear is simple, inexpensive and can be performed in the outpatient department. Hence, it should be recommended routinely as a method of improving reproductive health, early detection of premalignant and malignant cervical lesions. [Int J Res Med Sci 2015; 3(8.000: 1911-1916

  13. Decontamination of Steam Generator tube using Abrasive Blasting Technology

    International Nuclear Information System (INIS)

    As a part of a technology development of volume reduction and self disposal for large metal waste project, We at KAERI and our Sunkwang Atomic Energy Safety (KAES) subcontractor colleagues are demonstrating radioactively contaminated steam generator tube by abrasive blasting technology at Kori-1 NPP. A steam generator is a crucial component in a PWR (pressurized Water Reactor). It is the crossing between the primary, contaminated, circuit and the secondary waste-steam circuit. The heat from the primary reactor coolant loop is transferred to the secondary side in thousands of small tubes. Due to several problems in the material of those tube, like SCC (Stress Corrosion Cracking), insufficient control in water chemistry, which can be cause of tube leakage, more and more steam generators are replaced today. Only in Korea, already 2 of them are replaced and will be replaced in the near future. The retired 300 ton heavy Steam generator was stored at the storage waste building of Kori NPP site. The steam generator waste has a large volume, so that it is necessary to reduce its volume by decontamination. A waste reduction effect can be obtained through decontamination of the inner surface of a steam generator. Therefore, it is necessary to develop an optimum method for decontamination of the inner surface of bundle tubes. The dry abrasive blasting is a very interesting technology for the realization of three-dimensional microstructures in brittle materials like glass or silicon. Dry abrasive blasting is applicable to most surface materials except those that might be shattered by the abrasive. It is most effective on flat surface and because the abrasive is sprayed and can also applicable on 'hard to reach' areas such as inner tube ceilings or behind equipment. Abrasive decontamination techniques have been applied in several countries, including Belgium, the CIS, France, Germany, Japan, the UK and the USA

  14. Preoperative Arterial Interventional Chemotherapy on Cervical Cancer

    Institute of Scientific and Technical Information of China (English)

    WANG Hui; LING HU-Hua; TANG Liang-dan; ZHANG Xing-hua

    2008-01-01

    Objective:To discuss the therapeutic effect of preoperative interventional chemotherapy on cervical cancer.Methods:Preoperative interventional chemotherapy by femoral intubation was performed in 25 patients with bulky cervical cancer.The patients received bleomycin 45 mg and cisplatin or oxaliplatin 80 mg/m2.Results:25 cases(including 8 cases with stage Ⅰ and 17 cases with stage Ⅱ)received one or two courses of preoperative interventional chemotherapy.The size of the focal lesions was decreased greatly and radical hysterectomy and lymphadenectomy were performed successfully in all the patients.All of the specimens were sent for pathological examination.Lymphocyte infiltration was found more obvious in the cancer tissues as compared with their counterpart before treatment.As a result,relevant vaginal bleeding was stopped completely shortly after the treatment.Conclusion:Arterial interventional chemotherapy was proved to reduce the local size of cervical cancer and thus control the hemorrhage efficiently.The patients with cervical cancer can receive radical hysterectomy therapy after the interventional chemotherapy.

  15. Human papillomavirus types and recurrent cervical warts

    Energy Technology Data Exchange (ETDEWEB)

    Nuovo, G.J. (Columbia Presbyterian Medical Center, New York, NY (USA)); Pedemonte, B.M. (Harlem Hospital Medical Center, New York, NY (USA))

    1990-03-02

    The authors analyzed cervical intraepithelial neoplasias (CINs) detected after cryotherapy to determine if recurrence is associated with the same human papillomavirus (HPV) type found in the original lesion. Eight women had detectable HPV DNA in CINs that occurred after ablation of another CIN, and for each patient the HPV type in the pretreatment lesion was different from that in the CIN that appeared after cryotherapy. This compares with 12 women who had HPV detected in two or more CINs present at the same time, 11 of whom had the same HPv type noted. they concluded that although multiple, simultaneous CINs in a woman often contain the same HPV type, recurrent CINs that occur after cryotherapy contain an HPV type different from that present in the pretreatment lesion.

  16. Human papillomavirus types and recurrent cervical warts

    International Nuclear Information System (INIS)

    The authors analyzed cervical intraepithelial neoplasias (CINs) detected after cryotherapy to determine if recurrence is associated with the same human papillomavirus (HPV) type found in the original lesion. Eight women had detectable HPV DNA in CINs that occurred after ablation of another CIN, and for each patient the HPV type in the pretreatment lesion was different from that in the CIN that appeared after cryotherapy. This compares with 12 women who had HPV detected in two or more CINs present at the same time, 11 of whom had the same HPv type noted. they concluded that although multiple, simultaneous CINs in a woman often contain the same HPV type, recurrent CINs that occur after cryotherapy contain an HPV type different from that present in the pretreatment lesion

  17. Evaluation of dentifrice abrasion on human dentin and teeth enamel

    International Nuclear Information System (INIS)

    Radiometric method is applied to the dentifrice abrasion indicators evaluation: radioactive dentin (RDA) and radioactive enamel abrasion (REA). The dentifrices analysed presented RDA values varying from 95 to 13 and REA values from 7.1 to 0.7, showing a good precision, generally with relative standard deviations lower than 15.4%. Also, the dentifrices were classified as having low and medium cleaning potential. A correlation between RDA and REA values was obtained, i.e. dentifrices with high RDA values presented high REA ones. (author). 6 refs., 3 tabs

  18. An instrument for measuring abrasive water jet diameter

    OpenAIRE

    Junkar, Mihael; Lebar, Andrej; Orbanić, Henri

    2015-01-01

    In order to improve the accuracy of abrasive water jet (AW) machining the precise value of the jet diameter has to be known. Because of an aggressive environment caused by high velocity abrasive grains, the diameter is not easily measured. That is why a measuring device consisting of a load cell and a wear resistant probe was developed. The device measures the force of the jet while it passes over the edge of the probe. If the feed rate of the jet is constant and the time needed for jet to pa...

  19. Design and manufacturing of abrasive jet machine for drilling operation

    Directory of Open Access Journals (Sweden)

    Mittal Divyansh

    2016-01-01

    Full Text Available Wide application of Abrasive Jet Machine (AJM is found in machining hard and brittle materials. Machining of brittle materials by AJM is due to brittle fracture and removal of micro chips from the work piece. Embedment of the abrasive particles in the brittle materials results in decrease of machining efficiency. In this paper design and manufacturing of AJM has been presented. Various parts of AJM have been designed using ANSYS 16.2 software. The parts are then manufactured indigenously as per designed parameters. The machine fabricated in this work will be used further for process optimization of AJM parameters for machining of glass and ceramics.

  20. Avaliação da sensibilidade e especificidade dos exames citopatológico e colposcópico em relação ao exame histológico na identificação de lesões intra-epiteliais cervicais Sensibility and specificity of cytology and colposcopy exams with the histological evaluation of cervical intraepithelial lesions

    Directory of Open Access Journals (Sweden)

    FELIPE FRANCISCO BONDAN TUON

    2002-06-01

    Maternidade Santa Brígida de Curitiba, PR, were selected. Those patients were sent to colposcopy under the following criteria: 1 previous abnormal cytopathological exams, 2 Indicative clinical data or, 3 Suspected lesions on gynecological exam. The statistical significance analysis of the results was done using the chi-square test. Sensibility, specificity, positive predictive value (PPV and negative predictive value (NPV were also determined.RESULTS: The patients' mean age was 30.2 (±10.9. Cytopathological capability of identifying lesions was 50% when compared to histology. Its specificity was 77%, the sensibility 41%, the PPV 74%, and the NPV 45%. Colposcopy capability of identifying lesions was 50%. Its sensibility, specificity, PPV and NPV were 96%, 19%, 65% and 75% respectively. The two methods associated were capable of identifying 63% of the lesions.CONCLUSIONS: Cytopathology was a high specificity exam, while colposcopy from those selected patients had a high sensibility. Colposcopy association with cytopathological screening, on those selected patients, significantly raises the diagnostic accuracy of cervical cancer precursor lesions.

  1. INVERTED CONDYLOMA OF UTERINE CERVIX: A RARE CONDYLOMATOUS LESION

    Directory of Open Access Journals (Sweden)

    Prem Charles

    2014-10-01

    Full Text Available Human papillomavirus (HPV is an epitheliotropic virus that can infect and cause disease of skin or mucosa at any site. HPV associated lesions can be broadly divided into cutaneous and mucous membrane lesions. Cutaneous lesions include: warts, Butcher’s wart and epidermodysplasia verruciformis. The anogenital diseases, include warts (condyloma, dysplasia (cervical, vaginal, vulvar, anal, and squamous cell carcinoma. Here we are presenting a case report of a 27 year old female who was histologically diagnosed as inverted condyloma a rare condylomatous lesion involving the uterine cervix.

  2. HPVL1壳蛋白联合HPV分型检测在诊断子宫颈病变中的作用%HPV L1 protein unites HPV typing examination to diagnose cervical lesions

    Institute of Scientific and Technical Information of China (English)

    张露丹

    2011-01-01

    Objective To understind the HPV LI protein unites HPV typinge examination to diagnose the cervix pathological change. Methods The review from July, 2010 to January, 2011 carries on HPV in the second affiliated hospital of Zhengzhou University gynecoiogy department outpatient service the LI protein to unite HPV examination 403 patients were summarised the analyzed. Results When HPV LI protein and HPV typing examination ( - ) does not the found CIN 5 cases account for 0. 052% ; HPV LI protein and HPV typing examination( + ) in group CIN I 3 cases, CIN II 2 cases altogether account for 0. 086% ; In HPV LI protein( - ) , but HPVminute examination( + ) in group CIN I 59 cases, CIN II 37 cases, CIN Ⅲ 26 cases and the SCC 1 cases, the distinction accounts for 42.75% respectively, 26.81%, 18.84% and 0.007%. The fourth group has statistics significance with the first three group. Conclusions HPV LI protein and HPV typing examination in cervioal lesions has an important guiding funition, HPVLI protein deotction can be used as biological markers to forecast cevvical lesions progress.%目的 了解HPV L1壳蛋白联合HPV分型检测在诊断子宫颈病变中的作用.方法 回顾性的对在郑州大学第二附属医院妇科门诊2010年7月-2011年1月进行HPV L1壳蛋白联合HPV分型检测的403例患者进行总结和分析.结果 在HPV L1壳蛋白及HPV分型检测均(-)时没有CIN的出现;在HPV L1壳蛋白(+)而HPV分型检测(-)组中CIN Ⅰ有5例占0.052%;HPV L1壳蛋白及HPV分型检测均(+)组中CIN Ⅰ 3例、CINⅡ2例共占0.086;在HPV L1壳蛋白(-)而HPV分型检测(+)组CIN Ⅰ 59例Ⅱ37例、CINⅢ26例及SCC 1例,分别各占42.75%、26.81%、18.84%及0.007%.HpV L1壳蛋白(-)而HPV分型检测(+)组与前3组比较差异有统计学意义(P<0.05).结论 宫颈癌筛查十分必要,HPV L1壳蛋白联合HPV分型检测在诊断宫颈癌前病变中具有重要的指导作用,HPV L1壳蛋白检测可以作为预测官颈癌

  3. Abnormal Cervical Cancer Screening Test Results

    Science.gov (United States)

    ... AQ FREQUENTLY ASKED QUESTIONS FAQ187 GYNECOLOGIC PROBLEMS Abnormal Cervical Cancer Screening Test Results • What is cervical cancer screening? • What causes abnormal cervical cancer screening test ...

  4. Abrasion Properties of Steel Fiber Reinforced Silica Fume Concrete According to Los Angeles and Water Abrasion Tests

    OpenAIRE

    Tsan-Ching CHENG; Cheng, An; Huang, Ran; Lin, Wei-Ting

    2014-01-01

    The current study mainly investigated the influence of different tests on the abrasion resistance of concrete mixed with steel fibers and silica fume. The abrasion resistance was assessed at 28, 56 and 91 days on concretes with water-binder ratios of 0.35 and 0.55 where in some mixes silica fume was substituted by 5 % of cement by weight. Steel fibers of 0.5 % and 1.0 % of concrete volume were also added into the test concrete by replacement of coarse and fine aggregates. The results showed t...

  5. Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia

    OpenAIRE

    Torres-Poveda, Kirvis; Bahena-Román, Margarita; Madrid-González, Claudia; Ana I Burguete-García; Bermúdez-Morales, Víctor Hugo; Peralta-Zaragoza, Oscar; Madrid-Marina, Vicente

    2014-01-01

    Cervical cancer is a worldwide disease that constitutes a significant public health problem, especially in developing countries, not only due to its high incidence but also because the most affected population comprises women who belong to marginalized socio-economic classes. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients. Human Papillomavirus (HPV) has several mechanisms for avoiding the immune...

  6. Potential pitfall in the microfracturing technique during the arthroscopic treatment of an osteochondral lesion

    NARCIS (Netherlands)

    C.J.A. van Bergen; P.A.J. de Leeuw; C.N. van Dijk

    2009-01-01

    Debridement and bone marrow stimulation of the subchondral bone is currently considered to be the primary surgical treatment of most osteochondral lesions of the talus. Different methods of bone marrow stimulation are used, including drilling, abrasion, and microfracturing. The latter has gained rec

  7. Shore plartform abrasion in a para-periglacial environment, Galicia, northwestern Spain

    OpenAIRE

    Blanco Chao, Ramón; Pérez Alberti, Augusto; Trenhaile, A. S.; Costa-Casais, Manuela; Valcarcel-Díaz, Marcos

    2007-01-01

    [EN] The Schmidt Rock Test Hammer was used to study the effect of abrasion on shore platforms in Galicia, northwestern Spain. On platforms where tidally-induced weathering (salt, wetting and drying, etc.) is dominant, rock strength is significantly lower than in areas where abrasion is, or has been active in the recent past. This suggests that abrasion removes weathered surface material, exposing the stronger, less weathered rock below. Abrasion downwearing, measured with a transverse micro-e...

  8. MRI and PET Imaging in Predicting Treatment Response in Patients With Stage IB-IVA Cervical Cancer

    Science.gov (United States)

    2016-06-24

    Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Squamous Cell Carcinoma; Cervical Undifferentiated Carcinoma; Recurrent Cervical Carcinoma; Stage IB2 Cervical Cancer; Stage IIA Cervical Cancer; Stage IIB Cervical Cancer; Stage IIIA Cervical Cancer; Stage IIIB Cervical Cancer; Stage IVA Cervical Cancer

  9. Comparison of two commercial assays for detection of human papillomavirus (HPV) in cervical scrape specimens: validation of the Roche AMPLICOR HPV test as a means to screen for HPV genotypes associated with a higher risk of cervical disorders.

    NARCIS (Netherlands)

    Ham, M.A. van; Bakkers, J.M.J.E.; Harbers, G.; Quint, W.G.V.; Massuger, L.F.A.G.; Melchers, W.J.G.

    2005-01-01

    Certain high-risk (HR) human papillomavirus (HPV) types are a necessary cause for the development of cervical disorders. Women with persistent HR HPV infections have an increased risk of developing high-grade cervical lesions, compared with those who have no or low-risk HPV infections. Therefore, im

  10. CT rim effects in various head and neck lesions

    International Nuclear Information System (INIS)

    The authors evaluated various head and neck lesions seen from April 1988 through March 1990 both by plain and enhanced CT, examined the incidence of rim effect (or rim enhancement), classified these effects, and discussed underlying mechanisms. The subjects were 177 patients with primary tumors (28 benign and 49 malignant tumors), lymphadenopathy associated with malignancy (9), inflammatory lesions (20), cystic lesions (12), other lesions (7), and 22 without abnormal findings. Among these 177, rim effects were observed in 22 cases (12%). These effects were analyzed and classified. The incidences of rim effect according lesion type are as follows; cervical lymphadenopathy associated with malignancy 5/9 (56%), primary tumors 8/77 (10%), inflammatory lesions none, cystic lesions 7/12 (58%), and others 3/7 (43%). The highest incidence was seen with cystic lesions including mucoceles of the paranasal sinuses and cervical cysts. Rim effects were classified as follows; Type 1: cystic pattern, Type 2: parenchymatous pattern, Type 3: vascular pattern and Type 4: others. Type 1 was seen in 15 cases (68%), Type 2 in 3 cases (14%), Type 3 in 3 cases (14%), and Type 4 in 1 case (5%). Type 1 included 6 cystic lesions, 3 malignant lymphadenopathies, 3 benign tumors and others. Type 2 included 2 malignant lymphadenopathies and 1 benign tumor, and Type 3, 2 jugular thromboses and 1 carotid atheroma. There was only one Type 4, a cystic lesion. Of interest is the mode of incidences among cervical lymphadenopathies associated with malignancy. Accessory chains showed rim effects in 3/7, all Type 1, and jugular chains in 2/13, all Type 2. The mechanism underlying the rim effects was discussed and the vascularity of the peripheral rims of the lesions appeared to be the most important factor in addition to technical artifacts inherent in CT. (author)

  11. Cervical involvement in SAPHO syndrome: imaging findings with a 10-year follow-up

    Energy Technology Data Exchange (ETDEWEB)

    Tohme-Noun, C.; Krainik, A.; Menu, Y. [Department of Radiology, Hopital Beaujon, AP HP, Universite Paris 7, Faculte de medecine Bichat-Beaujon, Paris (France); Feydy, A. [Department of Radiology, Hopital Beaujon, AP HP, Universite Paris 7, Faculte de medecine Bichat-Beaujon, Paris (France); Department of Radiology, Hopital Beaujon, 100 avenue du General Leclerc, 92118, Clichy (France); Belmatoug, N.; Fantin, B. [Department of Internal Medicine, Hopital Beaujon, AP HP, Universite Paris 7, Faculte de medecine Bichat-Beaujon, Paris (France)

    2003-02-01

    Osteoarticular manifestations of SAPHO syndrome include vertebral lesions, typically in the thoracic segment. Chronic inflammatory changes are well depicted by MRI. We report the imaging findings with a 10-year follow-up in a case of SAPHO syndrome with marked cervical lesions. (orig.)

  12. Cervical involvement in SAPHO syndrome: imaging findings with a 10-year follow-up

    International Nuclear Information System (INIS)

    Osteoarticular manifestations of SAPHO syndrome include vertebral lesions, typically in the thoracic segment. Chronic inflammatory changes are well depicted by MRI. We report the imaging findings with a 10-year follow-up in a case of SAPHO syndrome with marked cervical lesions. (orig.)

  13. Application of combined detection of HR-HPV and TCT in screening for cervical cancer and precancerous lesions%高危型人乳头瘤病毒检测联合薄层液基细胞学检查在宫颈疾病筛查中的应用

    Institute of Scientific and Technical Information of China (English)

    叶波; 宋晓玉

    2015-01-01

    目的:进行高危型人乳头瘤病毒(HR-HPV)检测,分析液基薄层细胞学(TCT)检测与组织病理学诊断结果的符合情况,探讨二者联合检测对宫颈癌及癌前病变的筛查价值和意义。方法对1374例妇瘤科就诊患者,进行 HR-HPV、TCT 联合检测,对结果进行对比分析。结果684例意义不明的不典型鳞状细胞(ASCUS)患者病理学诊断结果中,炎症占51.3%,不典型增生轻度(CINⅠ)占47.4%;375例低度鳞状上皮内病变(LSIL)患者病理学诊断结果中,CINⅠ占48.5%,CINⅡ~Ⅲ占21.3%;294例高度鳞状上皮内病变(HSIL)患者病理学诊断结果中,CINⅠ占24.5%,CINⅡ~Ⅲ占62.9%;20例 SCC 患者病理学诊断结果中,CINⅡ~Ⅲ占20%,宫颈癌占80%。统计学分析显示,TCT 诊断与组织病理学诊断构成比差异有统计学意义(P <0.05)。HR-HPV 阳性率为74.3%,阴性率为25.7%。HR-HPV 阳性率随病理级别的升高而显著升高。HR-HPV 阳性组与阴性组病理诊断级别构成比差异有统计学意义(P <0.05)。TCT 与高危型 HPV 联合检测时,其灵敏度为76.5%,特异度为80.3%,联合检测的灵敏度和 TCT 差异有统计学意义(P <0.05),联合检测的特异度和 HR-HPV 差异有统计学意义(P <0.05)。结论 HR-HPV 检测与 TCT 联合能够提高宫颈病变的检出率,是一种较为理想的宫颈癌筛查方法。%Objective To study the status of coincidence of high-risk human papillomavirus(HR-HPV)test and thinprep cytolo-gy test with biopsy histopathologic diagnosis.And to investigate the value of combined detection in the diagnosis of the cervical cancer and precancerous lesions.Methods High-risk HPV test and thinprep cytology test were taken simultaneously in 1374 pa-tients visiting department of gynecological oncology.The diagnostic value of combination assay of these indices was evaluated.Re-sults In 684 patients with ASCUS pathology diagnosis,inflammation accounted for 5 1.3% and CINⅠ accounted for 47.4%.A-mong the

  14. 人乳头瘤病毒E6/E7mRNA检测在宫颈病变筛查中的应用价值%The application value of human papillomavirus E6/E7 mRNA detection in cervical lesions screening

    Institute of Scientific and Technical Information of China (English)

    张生枝; 邵华江; 马建婷

    2014-01-01

    目的:探讨人乳头瘤病毒(HPV)E6/E7 mRNA 检测在宫颈病变筛查中的应用价值。方法2012年6月至2013年4月在余姚市人民医院因宫颈炎症、阴道异常出血或排液的720例门诊患者行宫颈 TCT 和 HPV DNA 检测,对 TCT 结果≥ASC-US 或(和)高危 HPV DNA 阳性者行宫颈 HPV E6/E7mRNA 检测和组织病理学检查。以病理学结果为标准,与 HPV DNA 检测相比较,评价 HPV E6/E7 mRNA 检测对 CIN2+诊断价值,并用受试者工作特征(ROC)曲线评价其准确性。结果在 CIN 和宫颈浸润癌中,HPV E6/E7 mRNA 总体阳性率为78.7%,低于 HPV DNA 总体阳性率(92.6%),差异有统计学意义(P <0.001)。HPV E6/E7 mRNA 检测诊断 CIN2+的灵敏度为83.0%,低于 HPV DNA(94.5%),差异有统计学意义(P <0.01);特异度为51.1%,高于 HPV DNA(22.8%),差异有统计学意义(P <0.001)。 HPV E6/E7 mRNA、HPV DNA 对诊断 CIN2+的 ROC 曲线下面积分别为0.670、0.587, HPV E6/E7 mRNA 检测对 CIN2+的诊断的准确性高于 HPV DNA,差异有统计学意义(P <0.01)。结论 HPV E6/E7 mRNA 检测诊断 CIN2+特异度和准确性高于 HPV DNA,对宫颈病变的筛查有一定应用价值。%Objective To investigate the application value of detecting human papillomavirus(HPV)E6/E7 mRNA as a diagnose test for cervical lesions screening.Methods From June 2012 to April 2013,a total of 720 gynecological outpatients in Yangming Hospital affiliated to Medical School of Ningbo University,who had cervical inflammation,ab-normal vaginal bleeding or discharge ,received TCT and HPV DNA tests,and for those whose TCT≥ASC-US or/and high-risk HPV DNA-positive had HPV E6/E7 mRNA detection and histopathological examination.With the pathology results as the standard,the value of HPV E6/E7 mRNA detection for the diagnosis of CIN2+ was evaluated by com-parison with the HPV DNA test,and its

  15. Priority Setting for Improvement of Cervical Cancer Prevention in Iran

    Science.gov (United States)

    Majidi, Azam; Ghiasvand, Reza; Hadji, Maryam; Nahvijou, Azin; Mousavi, Azam-Sadat; Pakgohar, Minoo; Khodakarami, Nahid; Abedini, Mehrandokht; Amouzegar Hashemi, Farnaz; Rahnamaye Farzami, Marjan; Shahsiah, Reza; Sajedinejhad, Sima; Mohagheghi, Mohammad Ali; Nadali, Fatemeh; Rashidian, Arash; Weiderpass, Elisabete; Mogensen, Ole; Zendehdel, Kazem

    2016-01-01

    Background: Cervical cancer is the fourth most common cancer among women worldwide. Organized cervical screening and vaccination against human papilloma virus (HPV) have been successful interventions for prevention of invasive cervical cancer (ICC). Because of cultural and religious considerations, ICC has low incidence in Iran and many other Muslim countries. There is no organized cervical screening in these countries. Therefore, ICC is usually diagnosed in advanced stages with poor prognosis in these countries. We performed a priority setting exercise and suggested priorities for prevention of ICC in this setting. Methods: We invited experts and researchers to a workshop and asked them to list important suggestions for ICC prevention in Iran. After merging similar items and removing the duplicates, we asked the experts to rank the list of suggested items. We used a strategy grid and Go-zone analysis to determine final list of priorities for ICC prevention in Iran. Results: From 26 final items suggested as priorities for prevention of ICC, the most important priorities were developing national guidelines for cervical screening and quality control protocol for patient follow-up and management of precancerous lesions. In addition, we emphasized considering insurance coverage for cervical screening, public awareness, and research priorities, and establishment of a cervical screening registry. Conclusion: A comprehensive approach and implementation of organized cervical screening program is necessary for prevention of ICC in Iran and other low incidence Muslim countries. Because of high cost for vaccination and low incidence of cervical cancer, we do not recommend HPV vaccination for the time being in Iran.

  16. Priority Setting for Improvement of Cervical Cancer Prevention in Iran

    Directory of Open Access Journals (Sweden)

    Azam Majidi

    2016-04-01

    Full Text Available Background Cervical cancer is the fourth most common cancer among women worldwide. Organized cervical screening and vaccination against human papilloma virus (HPV have been successful interventions for prevention of invasive cervical cancer (ICC. Because of cultural and religious considerations, ICC has low incidence in Iran and many other Muslim countries. There is no organized cervical screening in these countries. Therefore, ICC is usually diagnosed in advanced stages with poor prognosis in these countries. We performed a priority setting exercise and suggested priorities for prevention of ICC in this setting. Methods We invited experts and researchers to a workshop and asked them to list important suggestions for ICC prevention in Iran. After merging similar items and removing the duplicates, we asked the experts to rank the list of suggested items. We used a strategy grid and Go-zone analysis to determine final list of priorities for ICC prevention in Iran. Results From 26 final items suggested as priorities for prevention of ICC, the most important priorities were developing national guidelines for cervical screening and quality control protocol for patient follow-up and management of precancerous lesions. In addition, we emphasized considering insurance coverage for cervical screening, public awareness, and research priorities, and establishment of a cervical screening registry. Conclusion A comprehensive approach and implementation of organized cervical screening program is necessary for prevention of ICC in Iran and other low incidence Muslim countries. Because of high cost for vaccination and low incidence of cervical cancer, we do not recommend HPV vaccination for the time being in Iran.

  17. Thermal annealing and ionic abrasion in ZnTe

    International Nuclear Information System (INIS)

    Thermal annealing of the ZnTe crystal is studied first in order to obtain information on the aspect of the penetration profile. Ionic abrasion is then investigated to find out whether it produces the same effects as ionic implantation, especially for luminescence

  18. Review of Artificial Abrasion Test Methods for PV Module Technology

    Energy Technology Data Exchange (ETDEWEB)

    Miller, David C. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Muller, Matt T. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Simpson, Lin J. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-08-01

    This review is intended to identify the method or methods--and the basic details of those methods--that might be used to develop an artificial abrasion test. Methods used in the PV literature were compared with their closest implementation in existing standards. Also, meetings of the International PV Quality Assurance Task Force Task Group 12-3 (TG12-3, which is concerned with coated glass) were used to identify established test methods. Feedback from the group, which included many of the authors from the PV literature, included insights not explored within the literature itself. The combined experience and examples from the literature are intended to provide an assessment of the present industry practices and an informed path forward. Recommendations toward artificial abrasion test methods are then identified based on the experiences in the literature and feedback from the PV community. The review here is strictly focused on abrasion. Assessment methods, including optical performance (e.g., transmittance or reflectance), surface energy, and verification of chemical composition were not examined. Methods of artificially soiling PV modules or other specimens were not examined. The weathering of artificial or naturally soiled specimens (which may ultimately include combined temperature and humidity, thermal cycling and ultraviolet light) were also not examined. A sense of the purpose or application of an abrasion test method within the PV industry should, however, be evident from the literature.

  19. Electrical resistivity measurements to predict abrasion resistance of rock aggregates

    Indian Academy of Sciences (India)

    Sair Kahraman; Mustafa Fener

    2008-04-01

    The prediction of Los Angeles (LA) abrasion loss from some indirect tests is useful for practical applications. For this purpose, LA abrasion, electrical resistivity, density and porosity tests were carried out on 27 different rock types. LA abrasion loss values were correlated with electrical resistivity and a good correlation between the two parameters was found. To see the effect of rock class on the correlation, regression analysis was repeated for igneous rocks, metamorphic rocks and sedimentary rocks, respectively. It was seen that correlation coefficients were increased for the rock classes. In addition, the data were divided into two groups according to porosity and density, respectively. After repeating regression analysis for these porosity and density groups, stronger correlations were obtained compared to the equation derived for all rocks. The validity of the derived equations was statistically tested and it was shown that all derived equations were significant. Finally, it can be said that all derived equations can alternatively be used for the estimation of LA abrasion loss from electrical resistivity.

  20. Cutting efficiency of partners abrasives according to UGN methodology

    Czech Academy of Sciences Publication Activity Database

    Vašek, Jaroslav

    Kraków : Institute of Metal Cutting , 2001 - (Wantuch, E.), s. 61-70 ISBN 83-912887-4-9. [International Conference on Water Jet Machining WJM 2001/2./. Kraków (PL), 15.11.2001-16.11.2001] Institutional research plan: CEZ:AV0Z3086906 Keywords : water jet * abrasives * cutting Subject RIV: BK - Fluid Dynamics

  1. Topographical anomaly on surfaces created by abrasive waterjet

    Czech Academy of Sciences Publication Activity Database

    Hloch, S.; Valíček, Jan

    2012-01-01

    Roč. 59, 5-8 (2012), s. 593-604. ISSN 0268-3768 Institutional research plan: CEZ:AV0Z30860518 Keywords : abrasive waterjet * initial zone * surface topography Subject RIV: JQ - Machines ; Tools Impact factor: 1.205, year: 2012 http://www.springerlink.com/content/5701144k76v02372

  2. Exaggerated abrasion/erosion of human dental enamel surfaces

    DEFF Research Database (Denmark)

    Westergaard, J; Moe, D; Pallesen, Ulla;

    1993-01-01

    An atypical, rapidly proceeding abrasion/erosion of the labial enamel surfaces of the maxillary and mandibular incisors and canines in a 27-yr-old man is reported. Ultrastructural examination of a replica of the teeth showed a practically structureless enamel surface both at the initial examinati...

  3. Innovative decontamination technology by abrasion in vibratory vessels

    International Nuclear Information System (INIS)

    Available in abstract form only. Full text of publication follows: The possibility of using conventional vibratory vessel technology as a decontamination technique is the motivation for the development of this project. The objective is to explore the feasibility of applying the vibratory vessel technology for decontamination of radioactively-contaminated materials such as pipes and metal structures. The research and development of this technology was granted by the U.S. Department of Energy (DOE). Abrasion processes in vibratory vessels are widely used in the manufacture of metals, ceramics, and plastics. Samples to be treated, solid abrasive media and liquid media are set up into a vessel. Erosion results from the repeated impact of the abrasive particles on the surface of the body being treated. A liquid media, generally detergents or surfactants aid the abrasive action. The amount of material removed increases with the time of treatment. The design and construction of the machine were provided by Vibro, Argentina private company. Tests with radioactively-contaminated aluminum tubes and a stainless steel bar, were performed at laboratory level. Tests showed that it is possible to clean both the external and the internal surface of contaminated tubes. Results show a decontamination factor around 10 after the first 30 minutes of the cleaning time. (authors)

  4. INDIVIDUALIZED TREATMENT OF PREINVASIVE LESIONS OF THE CERVIX

    Directory of Open Access Journals (Sweden)

    Neacsu Dorin

    2010-09-01

    Full Text Available The management of cervical preinvasive lesions in primary medical practice is characterized by a wide variety of attitudes, objectives and therapeutic decisions. The purpose of the study. To supply new landmarks referring to the preinvasive lesions of cervical cancer from the perspective of the clinician. Materials and methods. The study was made on a number of 16732 patients who were monitored comparatively in the Family Planning offices in the counties of Ia�i and Buz�u, between 2007 and 2011. Results and discussions. The treatment was applied according to the type of the lesion. Conclusions. The individualized treatment of the preinvasive lesions of the cervix targeted the destruction of the pathogenic agent and the infected tissues and caused a fibroblast proliferation and re-epithelisation

  5. HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia.

    Science.gov (United States)

    Peralta-Zaragoza, Oscar; Deas, Jessica; Gómez-Cerón, Claudia; García-Suastegui, Wendy Argelia; Fierros-Zárate, Geny Del Socorro; Jacobo-Herrera, Nadia Judith

    2013-01-01

    Cervical cancer is the second most common cause of death from cancer in women worldwide, and the development of new diagnostic, prognostic, and treatment strategies merits special attention. Many efforts have been made to design new drugs and develop immunotherapy and gene therapy strategies to treat cervical cancer. HPV genotyping has potentially valuable applications in triage of low-grade abnormal cervical cytology, assessment of prognosis and followup of cervical intraepithelial neoplasia, and in treatment strategies for invasive cervical cancer. It is known that during the development of cervical cancer associated with HPV infection, a cascade of abnormal events is induced, including disruption of cellular cycle control, alteration of gene expression, and deregulation of microRNA expression. Thus, the identification and subsequent functional evaluation of host proteins associated with HPV E6 and E7 oncoproteins may provide useful information in understanding cervical carcinogenesis, identifying cervical cancer molecular markers, and developing specific targeting strategies against tumor cells. Therefore, in this paper, we discuss the main diagnostic methods, management strategies, and followup of HPV-associated cervical lesions and review clinical trials applying gene therapy strategies against the development of cervical cancer. PMID:23690785

  6. HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia

    Directory of Open Access Journals (Sweden)

    Oscar Peralta-Zaragoza

    2013-01-01

    Full Text Available Cervical cancer is the second most common cause of death from cancer in women worldwide, and the development of new diagnostic, prognostic, and treatment strategies merits special attention. Many efforts have been made to design new drugs and develop immunotherapy and gene therapy strategies to treat cervical cancer. HPV genotyping has potentially valuable applications in triage of low-grade abnormal cervical cytology, assessment of prognosis and followup of cervical intraepithelial neoplasia, and in treatment strategies for invasive cervical cancer. It is known that during the development of cervical cancer associated with HPV infection, a cascade of abnormal events is induced, including disruption of cellular cycle control, alteration of gene expression, and deregulation of microRNA expression. Thus, the identification and subsequent functional evaluation of host proteins associated with HPV E6 and E7 oncoproteins may provide useful information in understanding cervical carcinogenesis, identifying cervical cancer molecular markers, and developing specific targeting strategies against tumor cells. Therefore, in this paper, we discuss the main diagnostic methods, management strategies, and followup of HPV-associated cervical lesions and review clinical trials applying gene therapy strategies against the development of cervical cancer.

  7. The Involvement of p53-miR-34a-CDK4 Signaling During the Development of Cervical Cancer

    Directory of Open Access Journals (Sweden)

    Huijun Zuo

    2015-01-01

    Conclusion: With the progression of cervical cancer lesions, the positive rate of p53 was greatly increased which may indicate its mutation, while miR-34a was down-regulated and CDK4 was up-regulated, which suggested that all these factors might be involved in the process of cervical oncogenesis.

  8. MRI in the assessment of a newborn with cervical teratoma

    Energy Technology Data Exchange (ETDEWEB)

    Green, J.S.; Dickinson, F.L.; Rickett, A. [Department of Radiology, Leicester Royal Infirmary, Leicester (United Kingdom); Moir, A. [Department of ENT Surgery, Leicester Royal Infirmary, Leicester (United Kingdom)

    1998-09-01

    Teratoma of the head and neck is a rare lesion comprising 6 % of all teratomas, with only 3 % occurring in the cervical region [1]. Most are non-malignant lesions consisting of a variety of tissues of variable maturity, commonly with neuroepithelial and thyroid elements. They often present as a large cystic mass in the neck of a neonate or infant and frequently cause respiratory embarrassment due to local mass effect necessitating urgent surgical intervention. They may be difficult to distinguish from cystic hygromas, both clinically and radiologically. Imaging plays an important role in the assessment of these lesions, especially in preparation for surgery. We present a case of cervical teratoma and emphasise the role of MRI. (orig.) With 2 figs., 6 refs.

  9. Inspeção visual do colo uterino após aplicação de ácido acético no rastreamento das neoplasias intra-epiteliais e lesões induzidas por HPV Cervical visual inspection after application of acetic acid in screening intraepithelial neoplasia and HPV-induced lesions

    Directory of Open Access Journals (Sweden)

    Maria Rachel Aguiar Cordeiro

    2005-02-01

    Full Text Available OBJETIVO: estimar a validade da inspeção visual após aplicação de ácido acético (IVA no rastreamento das neoplasias intra-epiteliais cervicais (NIC e lesões induzidas por HPV, comparando seu desempenho com o da colpocitologia e da colposcopia. MÉTODOS: estudo de validação de teste diagnóstico realizado em 893 mulheres de 18 a 65 anos, rastreadas simultaneamente com colpocitologia, IVA e colposcopia, em unidade de saúde pública de Recife, PE. A IVA foi realizada por embrocação do colo com ácido acético a 5% e observação a olho nu, com auxílio de foco clínico comum. Considerou-se como positividade o achado de qualquer lesão aceto-branca no colo. O padrão-ouro foi o histopatológico de biópsia cervical, realizado sempre que qualquer um dos três testes resultasse anormal. Foram estimados e comparados os indicadores de validade de cada teste, com os respectivos intervalos de confiança a 95%. A concordância entre os resultados dos testes foi avaliada pelo coeficiente kappa (k. RESULTADOS: das 303 mulheres biopsiadas, o estudo histopatológico foi anormal em 24. Deste total, a IVA foi positiva em 22, conferindo-lhe sensibilidade estimada de 91,7%, especificidade de 68,9%, valor preditivo positivo de 7,5% e valor preditivo negativo de 99,7%. Comparando-se os intervalos de confiança a 95%, a IVA mostrou maior sensibilidade que a colpocitologia, mas com menores especificidade e valor preditivo positivo. Houve fraca concordância entre os resultados da IVA e da colpocitologia (k=0,02 e excelente concordância com os da colposcopia (k=0,93. CONCLUSÃO: a IVA foi muito mais sensível que a colpocitologia no rastreamento das NIC e lesões HPV-induzidas e teve o mesmo desempenho da colposcopia. Sua baixa especificidade foi responsável por um elevado número de resultados falso-positivos.PURPOSE: to estimate the validity of visual inspection of cervical intraepithelial neoplasia (CIN and HPV-induced lesion screening, after acetic

  10. TREATMENT OF ABFRACTION LESION WITH TYPE II GLASS IONOMER CEMENT

    OpenAIRE

    Widya Wijayanti; Endang Suprastiwi

    2015-01-01

    Abfraction is a loss of tooth structure at the cervical area, which is caused by tensile and compressive strength. The loss of enamel may expose the dentin and will result in hypersensitivity of dentin and affects pulp vitality. The diagnosis could be identified in the presence of wedge shaped lesion, facet on the occlusal surface, usually affected one tooth only, and the presence of heavy occlusal loads. This lesion could be restored by a conventional glass-ionomer cement which has similar e...

  11. Congenital cervical bronchogenic cyst: A case report

    Directory of Open Access Journals (Sweden)

    Kiralj Aleksandar

    2015-01-01

    Full Text Available Introduction. Bronchogenic cysts are rare congenital anomalies of the embryonic foregut. They are caused by abnormal budding of diverticulum of the embryonic foregut between the 26th and 40th day of gestation. Bronchogenic cysts can appear in the mediastinum and pulmonary parenchyma, or at ectopic sites (neck, subcutaneous tissue or abdomen. So far, 70 cases of cervical localization of bronchogenic cysts have been reported. Majority of bronchogenic cysts have been diagnosed in the pediatric population. Bronchogenic cysts of the cervical area are generally asymptomatic and symptoms may occur if cysts become large or in case of infection of the cyst. The diagnosis is made based on clinical findings, radiological examination, but histopathologic findings are essential for establishing the final diagnosis. Treatment of cervical bronchogenic cyst involves surgical excision. Case Outline. Authors present a case of a 6-year-old female patient sent by a pediatrician to a maxillofacial surgeon due to asymptomatic lump on the left side of the neck. The patient had frequent respiratory infections and respiratory obstructions. Magnetic resonance imaging (MRI of the neck was performed and a well-circumscribed cystic formation on the left side of the neck was observed, with paratracheal location. The complete excision of the cyst was made transcervically. Histopathological findings pointed to bronchogenic cyst. Conclusion. Cervical bronchogenic cysts are rare congenital malformations. Considering the location, clinical findings and the radiological features, these cysts resemble other cervical lesions. Surgical treatment is important because it is both therapeutic and diagnostic. Reliable diagnosis of bronchogenic cysts is based on histopathological examination.

  12. The Epidemiology of Human Papillomavirus Infection and Cervical Cancer

    Directory of Open Access Journals (Sweden)

    F. Xavier Bosch

    2007-01-01

    Full Text Available Cervical cancer has been recognized as a rare outcome of a common Sexually Transmitted Infection (STI. The etiologic association is restricted to a limited number of viral types of the family of the Human Papillomaviruses (HPVs. The association is causal in nature and under optimal testing systems, HPV DNA can be identified in all specimens of invasive cervical cancer. As a consequence, it has been claimed that HPV infection is a necessary cause of cervical cancer. The evidence is consistent worldwide and implies both the Squamous Cell Carcinomas (SCC, the adenocarcinomas and the vast majority (i.e. > 95% of the immediate precursors, namely High Grade Squamous Intraepithelial Lesions (HSIL/Cervical Intraepithelial Neoplasia 3 (CIN3/Carcinoma in situ. Co-factors that modify the risk among HPV DNA positive women include the use of oral contraceptives (OC for five or more years, smoking, high parity (five or more full term pregnancies and previous exposure to other sexually transmitted diseases such as Chlamydia Trachomatis (CT and Herpes Simplex Virus type 2 (HSV-2. Women exposed to the Human Immunodeficiency Virus (HIV are at high risk for HPV infection, HPV DNA persistency and progression of HPV lesions to cervical cancer.

  13. Immunotherapy for Cervical Cancer

    Science.gov (United States)

    In an early phase NCI clinical trial, two patients with metastatic cervical cancer had a complete disappearance of their tumors after receiving treatment with a form of immunotherapy called adoptive cell transfer.

  14. Screening for Cervical Cancer

    Science.gov (United States)

    ... cervical cancer: • Cytology: This test, also called a Pap test or Pap smear, looks for abnormal changes in cells in ... women ages 21 to 65, screening with a Pap test every 3 years has the highest benefits ...

  15. Cervical motion segment replacement

    OpenAIRE

    Bryan, Vincent E.

    2002-01-01

    When symptoms bring to light a cervical spine degenerative disc process that requires surgical intervention, a symptom relieving procedure such as decompression, followed by functional restoration, arthroplasty, offers the benefit of prophylaxis of accelerated spondylosis at the operated level. In addition, by altering the biomechanical stress factors at adjacent levels, theoretically it should offer prophylactic benefit at these levels as well. The design requirements for a cervical disc pro...

  16. Cyclin A1 promoter hypermethylation in human papillomavirus-associated cervical cancer

    International Nuclear Information System (INIS)

    The aim of this study was to evaluate epigenetic status of cyclin A1 in human papillomavirus-associated cervical cancer. Y. Tokumaru et al., Cancer Res 64, 5982-7 (Sep 1, 2004)demonstrated in head and neck squamous-cell cancer an inverse correlation between cyclin A1 promoter hypermethylation and TP53 mutation. Human papillomavirus-associated cervical cancer, however, is deprived of TP53 function by a different mechanism. Therefore, it was of interest to investigate the epigenetic alterations during multistep cervical cancer development. In this study, we performed duplex methylation-specific PCR and reverse transcriptase PCR on several cervical cancer cell lines and microdissected cervical cancers. Furthermore, the incidence of cyclin A1 methylation was studied in 43 samples of white blood cells, 25 normal cervices, and 24, 5 and 30 human papillomavirus-associated premalignant, microinvasive and invasive cervical lesions, respectively. We demonstrated cyclin A1 methylation to be commonly found in cervical cancer, both in vitro and in vivo, with its physiological role being to decrease gene expression. More important, this study demonstrated that not only is cyclin A1 promoter hypermethylation strikingly common in cervical cancer, but is also specific to the invasive phenotype in comparison with other histopathological stages during multistep carcinogenesis. None of the normal cells and low-grade squamous intraepithelial lesions exhibited methylation. In contrast, 36.6%, 60% and 93.3% of high-grade squamous intraepithelial lesions, microinvasive and invasive cancers, respectively, showed methylation. This methylation study indicated that cyclin A1 is a potential tumor marker for early diagnosis of invasive cervical cancer

  17. MicroRNA expression variability in human cervical tissues.

    Directory of Open Access Journals (Sweden)

    Patrícia M Pereira

    Full Text Available MicroRNAs (miRNAs are short (approximately 22 nt non-coding regulatory RNAs that control gene expression at the post-transcriptional level. Deregulation of miRNA expression has been discovered in a wide variety of tumours and it is now clear that they contribute to cancer development and progression. Cervical cancer is one of the most common cancers in women worldwide and there is a strong need for a non-invasive, fast and efficient method to diagnose the disease. We investigated miRNA expression profiles in cervical cancer using a microarray platform containing probes for mature miRNAs. We have evaluated miRNA expression profiles of a heterogeneous set of cervical tissues from 25 different patients. This set included 19 normal cervical tissues, 4 squamous cell carcinoma, 5 high-grade squamous intraepithelial lesion (HSIL and 9 low-grade squamous intraepithelial lesion (LSIL samples. We observed high variability in miRNA expression especially among normal cervical samples, which prevented us from obtaining a unique miRNA expression signature for this tumour type. However, deregulated miRNAs were identified in malignant and pre-malignant cervical tissues after tackling the high expression variability observed. We were also able to identify putative target genes of relevant candidate miRNAs. Our results show that miRNA expression shows natural variability among human samples, which complicates miRNA data profiling analysis. However, such expression noise can be filtered and does not prevent the identification of deregulated miRNAs that play a role in the malignant transformation of cervical squamous cells. Deregulated miRNAs highlight new candidate gene targets allowing for a better understanding of the molecular mechanism underlying the development of this tumour type.

  18. MRI of anterior spinal artery syndrome of the cervical spinal cord

    International Nuclear Information System (INIS)

    Cervical spinal cord lesions in the anterior spinal artery syndrome were delineated on magnetic resonance images (MRI) in four patients. The lesion was always seen anteriorly in the cervical cord. On T2-weighted images, the lesions appeared hyperintense relative to the normal spinal cord, while on T1-weighted images, two chronic lesions appeared hypointense, with local atrophy of the cord. In one case, repeated T1-weighted images showed no signal abnormality 4 days after the ictus, but the lesion became hypointense 18 days later, when contrast enhancement was also recognized after injection of Gd-DTPA; this sequence of intensity changes was similar to that of cerebral infarction. The extent of the lesion seen MRI correlated closely with neurological findings in all cases. Although the findings may not be specific, MRI is now the modality of choice for confirming the diagnosis in patients suspected of having an anterior spinal artery syndrome. (orig.)

  19. MECHANISM AND PREDICTION OF MATERIAL ABRASION IN HIGH-VELOCITY SEDIMENT-LADEN FLOW

    Institute of Scientific and Technical Information of China (English)

    HUANG Xi-bin; YUAN Yin-zhong

    2006-01-01

    The wall surface of material is prone to silt abrasion by high-velocity sediment-laden flow. The silt abrasion is different form cavitation erosion. In this article, the characteristics of silt abrasion were discussed. The mechanism of silt abrasion was analyzed and the formation and development of ripple shape on wall surface of material were explained thereafter. Based on turbulence theory and test data, some formulas were derived for predicting the abrasion rate of concrete wall surface in high-velocity sediment-laden flow. The calculated results show good agreement with the experimental data.

  20. Study on abrasive mixing chamber of pre-mixed water jet

    OpenAIRE

    Junqing, Meng; Baisheng, Nie; Yechao, Ma; Bi, Zhao

    2015-01-01

    In order to reveal the flow law of isothermal, incompressible, steady, liquid-solid turbulent flow in mixing chamber of premixed abrasive water jet, the FLUENT software is used. The flow law of liquid-solid two phase flow is obtained. Abrasive mixing chamber models with four different sizes are used in this simulation, key design parameters of mine abrasive mixing chamber are determined. The flow laws of liquid-solid two phase flow in abrasive mixing chamber model with 7 different abrasive vo...

  1. Evaluation of the precision in the dentifrice abrasivity measurements obtained by a radiotracer method

    International Nuclear Information System (INIS)

    The radiotracer method was applied to evaluate the precision of the measurements of abrasivity data obtained for dentifrice samples and for abrasive agents (silica and calcium carbonate). This method consists of measuring 32P transferred to a dentifrice or abrasive slurry when an irradiated dentin is submitted to a brushing simulation. Results obtained for abrasivity indices had good precision with relative standard deviations lower than 11.8%. Comparisons made between our abrasivity index data with those obtained at the Oral Health Research Institute of Indiana University also showed a good agreement. (author)

  2. Cervical sympathetic chain schwannoma: A case report

    Directory of Open Access Journals (Sweden)

    Inès Nacef

    2014-07-01

    Full Text Available Nerve tumors arising from the sympathetic chain are uncommon slow-growing tumors and represent a diagnosis challenge. Their malignant degeneration is rare. Definitive pre-operative diagnosis may be difficult as investigations are not usually helpful. We report the case of a 23-year old woman who presented with an asymptomatic solitary left cervical swelling. She was evaluated with sonography and computed tomography. Complete surgical excision of the lesion was carried out and histologic examination revealed a schwannoma. Post-operatively, the patient showed clinical findings of Horner’s syndrome. Pathologic and radiological evaluation, differential diagnosis of this neoplasm and its management are discussed.

  3. Cervical cancer screening in Belgium and overscreening of adolescents.

    Science.gov (United States)

    Van Kerrebroeck, Helena; Makar, Amin

    2016-03-01

    There has been a marked decrease in the incidence of cervical cancer thanks to cytological screening with the Pap smear test. In Belgium, this screening is rather opportunistic. Over 39% of Belgian women between 25 and 64 years of age are never or only rarely screened by cytological tests. Moreover, there is an excess use of Pap smears because of women who rely on their yearly cervical smear and because many Pap smears are obtained from women beyond the target age range of 25 to 64 years. Sexually active adolescents are increasingly being recognized as a population distinct from adult women. They are at a high risk of acquiring the human papillomavirus (HPV), but most infections and cervical intraepithelial lesions caused by HPV are efficiently cleared by the immune system. We present a description of cervical cancer screening in Belgium using the database of the National Health Insurance Institute (RIZIV/INAMI) and the Belgian Health Care Knowledge Centre (KCE). We describe why elimination of Pap testing in the adolescent population reduces costs and harms without increasing cervical cancer rates. Expectant management, education on the risk factors for cervical cancer and HPV persistence, and HPV vaccination are very important in adolescents and young adults. PMID:25812038

  4. Giant cystic schwannoma of the middle mediastinum with cervical extension

    Directory of Open Access Journals (Sweden)

    Majdi Gueldich

    2015-04-01

    Full Text Available Schwannomas (neurilemmomas are benign tumors arising from the Schwann cells of the neural sheath. They are typically, well-encapsulated lesions which rarely adhere to the adjacent structures. In the chest, schwannomas are often seen within the posterior mediastinum and commonly originating along intercostal nerves. Several operative approaches have previously been described for the resection of these tumors, including thoracoscopic techniques and posterolateral thoracotomy. We report in this case a giant cystic mediastinal schwannoma of the left recurrent laryngeal nerve with cervical extension, unresectable by the usual described approaches, which was completely removed through a cervical approach.

  5. Intradural tumor and concomitant disc herniation of cervical spine

    Directory of Open Access Journals (Sweden)

    Mihir R Bapat

    2011-01-01

    Full Text Available We report a rare patient of a simultaneous extradural and intradural compression of the cervical spinal cord due to co-existent intervertebral disc herniation and an intradural schwannoma at the same level. The intradural lesion was missed resulting in recurrence of myelopathy after a surprisingly complete functional recovery following anterior cervical discectomy. Retrospectively, it was noted that the initial cord swelling noticed was tumor being masked by the compression produced by the herniated disc. A contrast magnetic resonance imaging scan is important in differentiating intradural tumors of the spinal cord. A high index of suspicion is often successful in unmasking both the pathologies.

  6. Can radical parametrectomy be omitted inoccult cervical cancer afterextrafascial hysterectomy?

    Institute of Scientific and Technical Information of China (English)

    Huai-WuLu,; JingLi,; Yun-YunLiu,; Chang-HaoLiu,; Guo-CaiXu,; Ling-LingXie,; Miao-FangWu; Zhong-QiuLin

    2015-01-01

    Background:Occult invasive cervical cancer discovered after simple hysterectomy is not common, radical parame‑trectomy (RP) is a preferred option for young women. However, the morbidity of RP was high. The aim of our study is to assess the incidence of parametrial involvement in patients who underwent radical parametrectomy for occult cervical cancer or radical hysterectomy for early‑stage cervical cancer and to suggest an algorithm for the triage of patients with occult cervical cancer to avoid RP. Methods:A total of 13 patients with occult cervical cancer who had undergone RP with an upper vaginectomy and pelvic lymphadenectomy were included in this retrospective study. Data on the clinicopathologic characteristics of the cases were collected. The published literature was also reviewed, and low risk factors for parametrial involvement in early‑stage cervical cancer were analyzed. Results:Of the 13 patients, 9 had a stage IB1 lesion, and 4 had a stage IA2 lesion. There were four patients with grade 1 disease, seven with grade 2 disease, and two with grade 3 disease. The median age of the entire patients was 41years. The most common indication for extrafascial hysterectomy was cervical intraepithelial neoplasia 3. Three patients had visible lesions measuring 10–30mm, in diameter and ten patients had cervical stromal invasions with depths ranging from 4 to 9mm; only one patient had more than 50% stromal invasion, and four patients had lymph‑vascular space invasion (LVSI). Perioperative complications included intraoperative bowel injury, blood transfusion, vesico‑vaginal ifstula, and ileus (1 case for each). Postoperative pathologic examination results did not show residual disease or parametrial involvement. One patient with positive lymph nodes received concurrent radiation therapy. Only one patient experienced recurrence. Conclusions:Perioperative complications following RP were common, whereas the incidence of parametrial involve‑ment was very low

  7. A clinical analysis of the incidences of non-carious cervical lesions and occlusal wear in the middle-aged and elderly%中老年人群牙颈部非龋性缺损与(牙合)面磨损的临床分析

    Institute of Scientific and Technical Information of China (English)

    杨焰; 金铁虎; 王芬芬; 但娇阳; 李明

    2013-01-01

    Objective: To investigate and analyze the incidences of non-carious cervical lesions and occlusal wear in the middle-aged and elderly, their correlations, and the possible risk factors associated with the formation of each. Method: A total of 568 office staff aged 45 years and above were involved. All the patients were examined for the presence and severity of NCCL and occlusal wear using the Tooth Wear Index (TWI). Result: The prevalence rates of NCCL and occlusal wear were observed 73.24 % and 87.50 % respectively in this population. Both the occurrence rates and tooth wear degrees were significantly related to the gender and the age. The prevalence of teeth with NCCL was significantly higher when the occlusal wear presented, and teeth with occlusal wear were more frequently observed the presence of NCCL (P <0.05). This study did not find significant associations between these two lesions and bruxism, dietary habits, and toothbrushing methods. Conclusion: NCCL and occlusal wear were common phenomena in the middle-aged and elderly. A relationship between the the incidences of each lesion was found. Occlusal force, mechanical friction and age were the common risk factors for NCCL and occlusal wear, but aggravating factors were different.%目的:调查中老年人群牙颈部非龋性缺损(NCCL)与(牙合)面磨损发生情况,并对两者的发病因素和相互关系进行探讨.方法:对568名45岁及以上机关干部,使用Smith和Knight牙齿磨损指数(TWI)进行牙颈部非龋性缺损与(牙合)面磨损的患病情况调查.结果:该研究人群NCCL的患病率为73.24%,(牙合)面磨损患病率为87.50%.NCCL和(牙合)面磨损的患病率和严重程度与性别和年龄相关,发生(牙合)面磨损的患牙更易发生NCCL,反之亦然(P<0.05).该人群的磨牙症史、饮食习惯及刷牙方法与NCCL和(牙合)面磨损的发生没有明显相关性.结论:牙颈部非龋性缺损与(牙合)面磨损在中老年人中较

  8. Anterior Cervical Spinal Surgery for Multilevel Cervical Myelopathy.

    OpenAIRE

    Jung-Ju Huang; Lih-Huei Chen; Chi-Chien Niu; Tsai-Sheng Fu; Po-Liang Lai; Wen-Jer Chen

    2004-01-01

    Background: In multilevel spinal cord compression caused by cervical spondylosis, surgeonsface the choice of performing a posterior route as a laminectomy orlaminoplasty, or an anterior route as multiple adjacent interbody decompressionsor corpectomies. The anterior cervical operation is not considered bysome clinicians because of concerns about complications and the complexityof multilevel anterior cervical surgery.Methods: In this retrospective study, 14 patients with multilevel cervical sp...

  9. Genotype distribution of human papillomavirus (HPV) in histological sections of cervical intraepithelial neoplasia and invasive cervical carcinoma in Madrid, Spain

    International Nuclear Information System (INIS)

    Human Papillomavirus (HPV) genotype distribution and co-infection occurrence was studied in cervical specimens from the city of Madrid (Spain), as a contribution to the knowledge of Human Papillomavirus genotype distribution and prevalence of carcinogenic HPV types in cervical lesions in Spain. A total of 533 abnormal specimens, from the Hospital General Universitario “Gregorio Marañón” of Madrid, were studied. These included 19 benign lesions, 349 cervical intraepithelial neoplasias 1 (CIN1), 158 CIN2-3 and 7 invasive cervical carcinomas (ICC). HPV genotyping was performed using PCR and tube array hybridization. We detected 20 different HPV types: 13 carcinogenic high-risk HPV types (HR-HPVs), 2 probably carcinogenic high-risk HPV types (PHR-HPVs) and 5 carcinogenic low-risk HPV types (LR-HPVs). The most frequent HPV genotypes found in all specimens were HPV16 (26.0%), 31 (10.7%) and 58 (8.0%). HPV 18 was only detected in 5.0%. Co-infections were found in 30.7% of CIN 1 and 18.4% cases of CIN2-3. The highest percentage of HR HPVs was found in those specimens with a CIN2-3 lesion (93.7%). As our study shows the current tetravalent vaccine could be effective in our geographical area for preventing all the invasive cervical carcinomas. In addition, upon the estimates of the important presence of other HR-HPV types – such as 31, 58, 33 and 52 – in different preneoplasic lesions the effectiveness of HPV vaccination in our geographical area, and others with similar genotype distribution, should be limited

  10. Optimization of Abrasive Water Jet Cutting of Ductile Materials

    Institute of Scientific and Technical Information of China (English)

    Asif IQBAL; Naeem U DAR; Ghulam HUSSAIN

    2011-01-01

    Full factorial design of experiments was developed in order to investigate the effects of jet pressure, abrasive mixing rate, cutting feed, and plate thickness upon three response variables, surface finish of cutting wear zone, percentage proportion of striation free area, and maximum width of cut. The set of sixteen experiments was performed on each of the following two ductile materials: AISI 4340 (high strength low alloy steel, hardened to 49HRc) and Aluminum 2219. Analysis of Variance (ANOVA) was performed on experimental data in order to determine the significance of effects of different parameters on the performance measures. It was found that cutting feed and thickness were highly influential parameters, while abrasive mixing rate is influential upon surface roughness only. Strong interaction was found between jet pressure and workpiece material.Multi-criteria numerical optimization was performed in order to simultaneously maximize/minimize different combinations of performance measures.

  11. Analysis of polymerization time on abrasive wear of dental resins

    Directory of Open Access Journals (Sweden)

    Eduardo Carlos Bianchi

    2010-03-01

    Full Text Available An evaluation was made of the abrasive wear of six composite thermofixed dental resins subjected to different polymerization times. The method of evaluation was based on sharpness measurements to quantify the abrasive wear resistance of the resins. To this end, a test bench was built, consisting of a rotating porcelain cylinder that wears out a resin-coated cylinder placed above it, thus causing vertical displacement of the contact as the wear progresses. The values of vertical displacement, i.e., the input variables, were read and recorded by means of a computer program to obtain the sharpness values. These data indicated that the resins displayed different behaviors as a function of the polymerization times applied, reinforcing the importance of using a practical and rapid method of analysis in order to ensure that the behavior of new materials is fully understood before they are launched on the market.

  12. Abrasion Testing of Critical Components of Hydrokinetic Devices

    Energy Technology Data Exchange (ETDEWEB)

    Worthington, Monty [ORPC Alaska; Ali, Muhammad [Ohio University; Ravens, Tom [University of Alaska Anchorage

    2013-12-06

    The objective of the Abrasion Testing of Critical Components of Hydrokinetic Devices (Project) was to test critical components of hydrokinetic devices in waters with high levels of suspended sediment – information that is widely applicable to the hydrokinetic industry. Tidal and river sites in Alaska typically have high suspended sediment concentrations. High suspended sediment also occurs in major rivers and estuaries throughout the world and throughout high latitude locations where glacial inputs introduce silt into water bodies. In assessing the vulnerability of technology components to sediment induced abrasion, one of the greatest concerns is the impact that the sediment may have on device components such as bearings and seals, failures of which could lead to both efficiency loss and catastrophic system failures.

  13. Superficial characterization of titanium league when submitted to abrasive blasting

    International Nuclear Information System (INIS)

    Commercially pure titanium and some of its alloys exhibit a good biocompatibility. These characteristics are frequently used in the manufacture of orthopedic and dental implants. It is possible to modify its surface making it the bioactive using various methods, such as deposition of hydroxyapatite by plasma spray and increasing the roughness of the surface by abrasive blasting. This work is to modify the surface of titanium alloy Ti6Al4V ELI (ASTM F136: 02a) for abrasive blasting and study the morphology, crystallographic phases and the mechanical characteristics of the surface obtained. For such purpose, SEM images, diffraction of X-rays and tests of risk produced by nanoindenter. The sandblasting was done using alumina powder and blasting time of 6s. The morphology of the surfaces of Ti6Al4V ELI changed after sandblasting with increased roughness. It is possible to conclude that after sandblasting the titanium surface do not have a ductile behavior. (author)

  14. UV/EB cured nanocomposites with scratch and abrasion properties

    International Nuclear Information System (INIS)

    The aim of this study was compare the effect of ultraviolet (UV) and electron beam (EB) on the properties of cured nanocomposites. Surface hardness of the cured materials was increased with the increased number of exposure (radiation doses) until optimum dose was achieved. This was due to the crosslinking during free radical polymerization process. Pendulum hardness, gel content (by soxhlet extraction) and thumb twist results were used to monitor the curing process and to characterize all the coating materials. Optimum dose was derived from the experiment and then was used to cure the coating materials for scratch and abrasion resistance study. It was found that the UV cured products showed excellent abrasion property than EB cured products. For scratch resistance property, EB curing process could provide the solution. (Author)

  15. Cervical cancer - screening and prevention

    Science.gov (United States)

    Cervical cancer is cancer that starts in the cervix. The cervix is the lower part of the uterus ( ... can do to decrease your chance of having cervical cancer. Also, tests done by your health care provider ...

  16. Is bovine dentine an appropriate substitute in abrasion studies

    OpenAIRE

    Wegehaupt, F J; Widmer, R.; Attin, T.

    2010-01-01

    The study aimed to compare the wear behaviour of human and bovine dentine due to toothbrushing with different relative dentin abrasivity (RDA) toothpastes. Forty human and 40 bovine dentine samples were prepared from bovine lower incisors or human premolars roots, and baseline surface profiles were recorded. The samples were distributed to four groups (each group n = 10 human and 10 bovine samples) and brushed with fluoridated experimental toothpastes with different RDAs (group A: RDA 10, B: ...

  17. Analysis of striation formation mechanism in abrasive water jet cutting

    OpenAIRE

    Junkar, Mihael; Orbanić, Henri

    2015-01-01

    In this paper the macro-mechanism of abrasive water jet (AWJ) cutting is studied from the point of cutting front and striation formation analysis. The striation on the surface cut with AWJ is a characteristic phenomena which is strongly present when cutting with high traverse velocities for particular material type and thickness of workpiece. The connection between the cutting front step formation and striation formation is explained through series of experiments, which include visual observa...

  18. Simulation of abrasive water jet cutting process - Part 1

    OpenAIRE

    Lebar, Andrej; Junkar, Mihael

    2015-01-01

    Abrasive water jet (AWJ) machined surfaces exhibit the texture typical of machining with high energy density beam processing technologies. It has a superior surface quality in the upper region and rough surface in the lower zone with pronounced texture marks called striations. The nature of the mechanisms involved in the domain of AWJ machining is still not well understood but is essential for AWJ control improvement. In this paper, the development of an AWJ machining simulation is reported o...

  19. Abrasive water-jet: controlled depth milling of titanium alloys

    OpenAIRE

    Fowler, Gary

    2003-01-01

    Abrasive waterjet (AWJ) technology is used in a routine manner in manufacturing industry to cut materials that are difficult to cut by other methods. Whilst the technology for through cutting of materials is mature, the process is also being developed for controlled depth milling (CDM) of materials. The aerospace industry have a requirement to remove redundant material from components manufactured from difficult to machine Ti6Al4V and titanium aluminide alloys and thus reduce component w...

  20. Abrasion of abutment screw coated with TiN

    OpenAIRE

    Jung, Seok-Won; Son, Mee-Kyoung; Chung, Chae-Heon; Kim, Hee-Jung

    2009-01-01

    STATEMENT OF PROBLEM Screw loosening has been a common complication and still reported frequently. PURPOSE The purpose of this study was to evaluate abrasion of the implant fixture and TiN coated abutment screw after repeated delivery and removal with universal measuring microscope. MATERIAL AND METHODS Implant systems used for this study were Osstem and 3i. Seven pairs of implant fixtures, abutments and abutment screws for each system were selected and all the fixtures were perpendicularly m...

  1. Polyurethanes from the crystalline prepolymers resistant to abrasive wear

    OpenAIRE

    Domańska Agata; Boczkowska Anna; Izydorzak-Woźniak Marta; Jaegermann Zbigniew; Grądzka-Dahlke Małgorzata

    2014-01-01

    The research aimed at the selection of polyurethanes synthesized from poly(tetramethylene ether) glycol (PTMEG), as well as from two different isocyanates 4,4′-methylenebis(cyclohexyl)isocyanate (HMDI) and 4.4′-methylenebis(phenyl isocyanate) (MDI) in order to obtain polyurethane with increased resistance to abrasive wear and degradation for bio-medical application. Polyurethanes were fabricated from crystalline prepolymers extended by water. The paper presents preliminary results on polyuret...

  2. Tangental Turning of Incoloy Alloy 925 Using Abrasive Water Jet

    Czech Academy of Sciences Publication Activity Database

    Cárach, J.; Hloch, Sergej; Hlaváček, Petr; Vasilko, K.; Lehocká, D.

    Zagreb: Croatian Association of Production Engineering, 2015 - (Abele, E.; Udiljak, T.; Ciglar, D.), s. 77-80 ISBN 978-953-7689-03-2. [CIM 2015 - International Scientific Conference on Production Engineering. Vodice (HR), 10.06.2015-13.06.2015] R&D Projects: GA MŠk(CZ) LO1406; GA MŠk ED2.1.00/03.0082 Institutional support: RVO:68145535 Keywords : incoloy alloy 925 * abrasive water jet turning * traverse speed Subject RIV: JQ - Machines ; Tools

  3. Wear and abrasion resistance selection maps of biological materials.

    Science.gov (United States)

    Amini, Shahrouz; Miserez, Ali

    2013-08-01

    The mechanical design of biological materials has generated widespread interest in recent years, providing many insights into their intriguing structure-property relationships. A critical characteristic of load-bearing materials, which is central to the survival of many species, is their wear and abrasion tolerance. In order to be fully functional, protective armors, dentitious structures and dynamic appendages must be able to tolerate repetitive contact loads without significant loss of materials or internal damage. However, very little is known about this tribological performance. Using a contact mechanics framework, we have constructed materials selection charts that provide general predictions about the wear performance of biological materials as a function of their fundamental mechanical properties. One key assumption in constructing these selection charts is that abrasion tolerance is governed by the first irreversible damage at the contact point. The maps were generated using comprehensive data from the literature and encompass a wide range of materials, from heavily mineralized to fully organic materials. Our analysis shows that the tolerance of biological materials against abrasion depends on contact geometry, which is ultimately correlated to environmental and selective pressures. Comparisons with experimental data from nanoindentation experiments are also drawn in order to verify our predictions. With the increasing amount of data available for biological materials also comes the challenge of selecting relevant model systems for bioinspired materials engineering. We suggest that these maps will be able to guide this selection by providing an overview of biological materials that are predicted to exhibit the best abrasion tolerance, which is of fundamental interest for a wide range of applications, for instance in restorative implants and protective devices. PMID:23643608

  4. Relationship between the Expression of Telomerase and Human Papillomavirus Infection in Invasive Uterine Cervical Carcinoma

    Institute of Scientific and Technical Information of China (English)

    SIMA Ni; CAI Liping; ZHU Yuanfang; WANG Wei; WANG Shixuan; MA Ding

    2007-01-01

    Telomerase activity was examined in invasive cervical carcinoma to assess whether it is activated during cervical malignant transformation and to look for its possible association with human papillomavirus (HPV) infection. Histologically confirmed invasive cervical carcinomas and benign cervices were assayed for telomerase activity by using a modified telomere repeat amplification protocol (TRAP). The same cases were subjected to polymerase chain reaction (PCR) detection of HPV by using consensus primers and type-specific (HPV types 16 and 18) primers. Telomerase activity was detected in 40 of 45 (88.9%) invasive cervical carcinomas and 2 (all chronic cervicitis) of 50 (4%) benign cervical lesions. HPV was detected in 36 (24 HPV-16 and 4 HPV-18 cases) of 45 (80%) invasive cervical carcinomas and 20 (11 HPV-16 and 1 HPV-18 cases) of 50 (40%) benign cervical changes. There was a significant correlation between the expression of telomerase with histological grade (φ=0.44, P<0.005), but no correlation was found between telomerase expression and HPV-18 (P>0.05). Although larger sample studies are needed, there seems to be a clear association between telomerase upregulation and HPV status, mainly HPV-16 infection.

  5. Expression of the CXCL12/CXCR4 and CXCL16/CXCR6 axes in cervical intraepithelial neoplasia and cervical cancer

    Institute of Scientific and Technical Information of China (English)

    Yu Huang; Jia Zhang; Zhu-Mei Cui; Jing Zhao; Ye Zheng

    2013-01-01

    The chemokine CXCL12 is highly expressed in gynecologic tumors and is widely known to play a biologically relevant role in tumor growth and spread.Recent evidence suggests that CXCL16,a novel chemokine,is overexpressed in inflammation-associated tumors and mediates pro-tumorigenic effects of inflammation in prostate cancer.We therefore analyzed the expression of CXCL12 and CXCL16 and their respective receptors CXCR4 and CXCR6 in cervical intraepithelial neoplasia (CIN) and cervical cancer and further assessed their association with clinicopathologic features and outcomes.Tissue chip technology and immunohistochemistry were used to analyze the expression of CXCL12,CXCR4,CXCL16,and CXCR6 in healthy cervical tissue (21 cases),CIN (65 cases),and cervical carcinoma (60 cases).The association of protein expression with clinicopathologic features and overall survival was analyzed.These four proteins were clearly detected in membrane and cytoplasm of neoplastic epithelial cells,and their distribution and intensity of expression increased as neoplastic lesions progressed through CIN1,CIN2,and CIN3 to invasive cancer.Furthermore,the expression of CXCR4 was associated significantly with the histologic grade of cervical carcinoma,whereas the expression of CXCR6 was associated significantly with lymph node metastasis.In Kaplan-Meier analysis,patients with high CXCR6 expression had significantly shorter overall survival than did those with low CXCR6 expression.The elevated co-expression levels of CXCL12/CXCR4 and CXCL16/CXCR6 in CIN and cervical carcinoma suggest a durative process in cervical carcinoma development.Moreover,CXCR6 may be useful as a biomarker and a valuable prognostic factor for cervical cancer.

  6. Expression of the CXCL12/CXCR4 and CXCL16/CXCR6 axes in cervical intraepithelial neoplasia and cervical cancer

    Directory of Open Access Journals (Sweden)

    Ye Zheng

    2013-05-01

    Full Text Available The chemokine CXCL12 is highly expressed in gynecologic tumors and is widely known to play a biologically relevant role in tumor growth and spread. Recent evidence suggests that CXCL16, a novel chemokine, is overexpressed in inflammation-associated tumors and mediates pro-tumorigenic effects of inflammation in prostate cancer. We therefore analyzed the expression of CXCL12 and CXCL16 and their respective receptors CXCR4 and CXCR6 in cervical intraepithelial neoplasia (CIN and cervical cancer and further assessed their association with clinicopathologic features and outcomes. Tissue chip technology and immunohistochemistry were used to analyze the expression of CXCL12, CXCR4, CXCL16, and CXCR6 in healthy cervical tissue (21 cases, CIN (65 cases, and cervical carcinoma (60 cases. The association of protein expression with clinicopathologic features and overall survival was analyzed. These four proteins were clearly detected in membrane and cytoplasm of neoplastic epithelial cells, and their distribution and intensity of expression increased as neoplastic lesions progressed through CIN1, CIN2, and CIN3 to invasive cancer. Furthermore, the expression of CXCR4 was associated significantly with the histologic grade of cervical carcinoma, whereas the expression of CXCR6 was associated significantly with lymph node metastasis. In Kaplan-Meier analysis, patients with high CXCR6 expression had significantly shorter overall survival than did those with low CXCR6 expression. The elevated co-expression levels of CXCL12/CXCR4 and CXCL16/CXCR6 in CIN and cervical carcinoma suggest a durative process in cervical carcinoma development. Moreover, CXCR6 may be useful as a biomarker and a valuable prognostic factor for cervical cancer.

  7. Effects of gill abrasion and experimental infection with Tenacibaculum maritimum on the respiratory physiology of Atlantic salmon Salmo salar affected by amoebic gill disease.

    Science.gov (United States)

    Powell, Mark D; Harris, James O; Carson, Jeremy; Hill, Jonathan V

    2005-02-28

    The effects of gill abrasion and experimental infection with Tenacibaculum maritimum were assessed in Atlantic salmon Salmo salar with underlying amoebic gill disease. The respiratory and acid-base parameters arterial oxygen tension (P(a)O2), arterial whole blood oxygen content (C(a)O2), arterial pH (pHa), haematocrit and haemoglobin concentrations were measured at intervals over a 48 h recovery period following surgical cannulation of the dorsal aorta. Mortality rates over the recovery period were variable, with gill abrasion and inoculation with T. maritimum causing the highest initial mortality rate and unabraded, uninoculated controls showing the lowest overall mortality rate. Fish with abraded gills tended to show reduced P(a)O2 and lower C(a)O2 compared with unabraded fish. Infection with T. maritimum had no effect on P(a)O2 or C(a)O2. All fish showed an initial alkalosis at 24 h post-surgery/inoculation which was more pronounced in fish inoculated with T. maritimum. There were no significant effects of gill abrasion or infection upon the ratio of oxygen specifically bound to haemoglobin or mean cellular haemoglobin concentration. Histologically, 48 h following surgery, abraded gills showed multifocal hyperplastic lesions with pronounced branchial congestion and telangiectasis, and those inoculated with T. maritimum exhibited focal areas of branchial necrosis and erosion associated with filamentous bacterial mats. All fish examined showed signs of amoebic gill disease with multifocal hyperplastic and spongious lesions with parasome-containing amoeba associated with the gill epithelium. The results suggest that respiratory compromise occurred as a consequence of gill abrasion rather than infection with T. maritimum. PMID:15819432

  8. Comparing the Air Abrasion Cutting Efficacy of Dentine Using a Fluoride-Containing Bioactive Glass versus an Alumina Abrasive: An In Vitro Study

    Directory of Open Access Journals (Sweden)

    Melissa H. X. Tan

    2015-01-01

    Full Text Available Air abrasion as a caries removal technique is less aggressive than conventional techniques and is compatible for use with adhesive restorative materials. Alumina, while being currently the most common abrasive used for cutting, has controversial health and safety issues and no remineralisation properties. The alternative, a bioactive glass, 45S5, has the advantage of promoting hard tissue remineralisation. However, 45S5 is slow as a cutting abrasive and lacks fluoride in its formulation. The aim of this study was to compare the cutting efficacy of dentine using a customised fluoride-containing bioactive glass Na0SR (38–80 μm versus the conventional alumina abrasive (29 μm in an air abrasion set-up. Fluoride was incorporated into Na0SR to enhance its remineralisation properties while strontium was included to increase its radiopacity. Powder outflow rate was recorded prior to the cutting tests. Principal air abrasion cutting tests were carried out on pristine ivory dentine. The abrasion depths were quantified and compared using X-ray microtomography. Na0SR was found to create deeper cavities than alumina (p<0.05 despite its lower powder outflow rate and predictably reduced hardness. The sharper edges of the Na0SR glass particles might improve the cutting efficiency. In conclusion, Na0SR was more efficacious than alumina for air abrasion cutting of dentine.

  9. Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma

    OpenAIRE

    Mehta, Akash M.; Jordanova, Ekaterina S.; Kenter, Gemma G; Ferrone, Soldano; Fleuren, Gert- Jan

    2007-01-01

    HLA class I loss is a significant mechanism of immune evasion by cervical carcinoma, interfering with the development of immunotherapies and cancer vaccines. We report the systematic investigation of HLA class I and antigen processing machinery component expression and association with clinical outcome. A tissue microarray containing carcinoma lesions from 109 cervical carcinoma patients was stained for HLA class I heavy chains, β2-microglobulin, LMP2, LMP7, LMP10, TAP1, TAP2, ERAP1, tapasin,...

  10. The SUMO conjugating enzyme UBC9 as a biomarker for cervical HPV infections

    OpenAIRE

    Mattoscio, Domenico; Casadio, Chiara; Fumagalli, Marzia; Sideri, Mario; Chiocca, Susanna

    2015-01-01

    Human papillomaviruses (HPVs) infect stratified epithelium and are the causative agents of cervical cancer, the second most common cause of cancer-related death in women. A critical aspect that still persists in the HPV field is the selection of very sensitive and specific HPV diagnostic assays. Here, we provide evidence that the crucial small ubiquitin-like modifier (SUMO) E2-conjugating enzyme Ubc9 is strongly upregulated in cervical lesions. Ubc9 detection could thus be used in diagnosing ...

  11. Histological Correlation of Glandular Abnormalities in Cervical Liquid-Based Cytology

    OpenAIRE

    Yosuke Kawakami; Tamaki Toda; Toshinao Nishimura; Junichi Sakane; Kazuya Kuraoka; Kazuhiro Takehara; Tomoya Mizunoe; Kiyomi Taniyama

    2011-01-01

    Conventional Papanicolaou smear method is still commonly used for cervical cancer screening in Japan, despite the liquid-based cytology (LBC) that has become a global tendency in the world recently. One of the obstacles in the way of popularization of this method seems to be the confusion as to diagnosis upon cervical glandular lesions. We performed comparison study between LBC and conventional Papanicolaou smear about cytological diagnosis using split-sample method in 4522 patients. In 13 ca...

  12. Reduced expression of multiple gap junction proteins is a feature of cervical dysplasia

    OpenAIRE

    Edward Mike; Graham Sheila V; Aasen Trond; Hodgins Malcolm B

    2005-01-01

    Abstract Cervical dysplasia is a premalignant lesion associated with human papillomavirus (HPV) infection which, over time, can turn cancerous. Previous studies have indicated that loss of gap junctions may be a feature of cervical cancer and premalignant dysplasia. Loss of the gap junction protein connexin43 has been demonstrated in dysplastic cervix, but other connexins have not been investigated. In contrast we previously showed that HPV-associated cutaneous warts – and other hyperprolifer...

  13. Prevalence of human papillomavirus in the cervical epithelium of Mexican women: meta-analysis

    OpenAIRE

    Peralta-Rodríguez Raúl; Romero-Morelos Pablo; Villegas-Ruíz Vanessa; Mendoza-Rodríguez Mónica; Taniguchi-Ponciano Keiko; González-Yebra Beatriz; Marrero-Rodríguez Daniel; Salcedo Mauricio

    2012-01-01

    Abstract Background Human Papillomavirus (HPV) in cervical epithelium has been identified as the main etiological factor in the developing of Cervical Cancer (CC), which has recently become a public health problem in Mexico. This finding has allowed for the development of vaccines that help prevent this infection. In the present study, we aimed to determine the prevalence and HPV type-distribution in Mexican women with CC, high-grade squamous intraepithelial lesion (HSIL), low-grade squamous ...

  14. Anterior spinal artery syndrome of the cervical hemicord.

    Science.gov (United States)

    Baumgartner, R W; Waespe, W

    1992-01-01

    Three patients developed signs of a unilateral cervical cord lesion 6 to 36 h after the acute onset of severe cervico-brachial pain. The neurological deficit progressed over 6 to 18 h. On the painful side a central Horner's syndrome, a hemiparesis with plegia of the hand, and a slight pallhypaesthesia were found. On the opposite side thermhypaesthesia and hypalgesia were noted with a level at the dermatome C5 or C6. T2-weighted MR images revealed in one patient a small area of increased signal intensity restricted to one half of the cervical cord, and electromyography in another patient showed after 6 months evidence of segmental chronic denervation. Both abnormalities were found at the clinically expected level. The findings are consistent with a small infarction of the cervical cord in the perfusion territory of a central (sulco-commissural) artery, a duplicated anterior spinal artery or an anterior spinal branch of the vertebral artery. PMID:1315578

  15. Preprocessing for Automating Early Detection of Cervical Cancer

    CERN Document Server

    Das, Abhishek; Bhattacharyya, Debasis

    2011-01-01

    Uterine Cervical Cancer is one of the most common forms of cancer in women worldwide. Most cases of cervical cancer can be prevented through screening programs aimed at detecting precancerous lesions. During Digital Colposcopy, colposcopic images or cervigrams are acquired in raw form. They contain specular reflections which appear as bright spots heavily saturated with white light and occur due to the presence of moisture on the uneven cervix surface and. The cervix region occupies about half of the raw cervigram image. Other parts of the image contain irrelevant information, such as equipment, frames, text and non-cervix tissues. This irrelevant information can confuse automatic identification of the tissues within the cervix. Therefore we focus on the cervical borders, so that we have a geometric boundary on the relevant image area. Our novel technique eliminates the SR, identifies the region of interest and makes the cervigram ready for segmentation algorithms.

  16. Preprocessing: A Step in Automating Early Detection of Cervical Cancer

    CERN Document Server

    Das, Abhishek; Bhattacharyya, Debasis

    2011-01-01

    Uterine Cervical Cancer is one of the most common forms of cancer in women worldwide. Most cases of cervical cancer can be prevented through screening programs aimed at detecting precancerous lesions. During Digital Colposcopy, colposcopic images or cervigrams are acquired in raw form. They contain specular reflections which appear as bright spots heavily saturated with white light and occur due to the presence of moisture on the uneven cervix surface and. The cervix region occupies about half of the raw cervigram image. Other parts of the image contain irrelevant information, such as equipment, frames, text and non-cervix tissues. This irrelevant information can confuse automatic identification of the tissues within the cervix. Therefore we focus on the cervical borders, so that we have a geometric boundary on the relevant image area. Our novel technique eliminates the SR, identifies the region of interest and makes the cervigram ready for segmentation algorithms.

  17. The degenerative cervical spine.

    Science.gov (United States)

    Llopis, E; Belloch, E; León, J P; Higueras, V; Piquer, J

    2016-04-01

    Imaging techniques provide excellent anatomical images of the cervical spine. The choice to use one technique or another will depend on the clinical scenario and on the treatment options. Plain-film X-rays continue to be fundamental, because they make it possible to evaluate the alignment and bone changes; they are also useful for follow-up after treatment. The better contrast resolution provided by magnetic resonance imaging makes it possible to evaluate the soft tissues, including the intervertebral discs, ligaments, bone marrow, and spinal cord. The role of computed tomography in the study of degenerative disease has changed in recent years owing to its great spatial resolution and its capacity to depict osseous components. In this article, we will review the anatomy and biomechanical characteristics of the cervical spine, and then we provide a more detailed discussion of the degenerative diseases that can affect the cervical spine and their clinical management. PMID:26878769

  18. Significance of micronucleus in cervical intraepithelial lesions and carcinoma

    Directory of Open Access Journals (Sweden)

    B N Gayathri

    2012-01-01

    Conclusions: MN scoring on the epithelial cells of cervix could be used as a biomarker in cancer screening. This is an easy, simple, reliable, reproducible and objective test which can be performed on routinely stained pap smears.

  19. Lateral Pectoral Nerve Injury Mimicking Cervical Radiculopathy.

    Science.gov (United States)

    Aktas, Ilknur; Palamar, Deniz; Akgun, Kenan

    2015-07-01

    The lateral pectoral nerve (LPN) is commonly injured along with the brachial plexus, but its isolated lesions are rare. Here, we present a case of an isolated LPN lesion confused with cervical radiculopathy. A 41-year-old man was admitted to our clinic because of weakness in his right arm. Previous magnetic resonance imaging (MRI) examination revealed right posterolateral protrusion at the C6-7 level. At the initial assessment, atrophy of the right pectoralis major muscle was evident, and mild weakness of the right shoulder adductor, internal rotator, and flexor muscles was observed. Therefore, electrodiagnostic evaluation was performed, and a diagnosis of isolated LPN injury was made. Nerve injury was thought to have been caused by weightlifting exercises and traction injury. Lateral pectoral nerve injury can mimic cervical radiculopathy, and MRI examination alone may lead to misdiagnosis. Repeated physical examinations during the evaluation and treatment phase will identify the muscle atrophy that occurs 1 or more months after the injury. PMID:25290103

  20. Rheumatoid cervical myelopathy

    International Nuclear Information System (INIS)

    Rheumatoid cervical myelopathy was studied in 14 patients, clinically, radiographically and by computerized tomography with multiplanar reconstruction (CT/MPR). CT/MPR demonstrated significant unsuspected areas of compromise in 9 of the 14 patients, and altered the surgical procedure in 7 of these 9 patients. CT/MPR clearly identifies all levels of involvement including rotary subluxation. CT/MPR also allows assessment of the spinal nerve canal/foramen and the alignment of the foramina transversaria. CT/MPR is an essential addition to the evaluation of rheumatoid cervical myelopathy

  1. CERVICAL NECROTIZING FASCIITIS

    Directory of Open Access Journals (Sweden)

    G. Dimofte

    2009-05-01

    Full Text Available Cervical necrotizing fasciitis is an unusual encounter in the general surgical practice, but is a life-threatening condition requiring early recognition and adequate surgical treatment. We present the case of a 65 year old male patient referred to our department from a General Hospital. Large excisions of both superficial and deep cervical fascia were required together with necrotic skin on a very large surface. Rapid recovery with early sterilization allowed adequate skin grafting with good results. We advocate for aggressive debridment with excision in viable healthy tissue, with no concern for the future reconstruction followe by early grafting of the skin defect.

  2. [Muscle-tendon echography in acute cervical sprain traumas. Preliminary results].

    Science.gov (United States)

    Martino, F; Ettorre, G C; Cafaro, E; Macarini, L; Bancale, R; Sion, E

    1992-03-01

    Acute cervical sprain traumas can be divided into simple and severe, depending on the presence of organic lesions which can be documented by conventional radiologic techniques. Persistent painful symptomatology of the nape and the precise localization of pain, led us to suspect the presence of organic lesions due to tearing of the neck muscles in 94 patients who had suffered a simple cervical sprain. To demonstrate these post-traumatic lesions, the patients were subjected to US examinations of both the nape and the muscles at the base of the neck. In 13 cases (13.8%) muscular tearing lesions were demonstrated, which were characterized by hypoechoic lacunae (6 cases), by hyperechoic stripes (5 cases), and by muscular hernia (1 case); in 1 case, partial disconnection of a muscular insertion was demonstrated. Thus, we believe muscle-tendon US to be a valuable technique for both diagnostic and nosologic purposes, for the method allows simple cervical sprain to be discriminated from sprains which are complicated by organic muscular lesions. We suggest that the cervical sprain traumas where a muscular lesion due to tearing can be demonstrated be defined as "complex" traumas. PMID:1579667

  3. THE SPECTRUM OF CERVICAL CYTOLOGICAL ABNORMALITIES IN KUWAIT USING THE REVISED 2001 BETHESDA SYSTEM

    Directory of Open Access Journals (Sweden)

    Thoppil Reba

    2014-08-01

    Full Text Available Cervical carcinoma is one of the most common female malignancies in developing countries. There are few reports describing the profile of abnormal Pap smears from countries in the Middle East. The pattern of cervical intraepithelial lesions and carcinoma detected in Pap smears of women in Kuwait is reported. A total of 12800 cervical smears reported in the department of Pathology, Maternity Hospital, and ministry of Health were studied from January 2010 to December 2012. There were 523(4.12% abnormal Pap smears. They were further classified as Atypical Squamous cells of undetermined significance (ASCUS (118 cases, 0.93%, Atypical Squamous cells cannot exclude a HSIL (ASC-H (24 cases, 0.19%, Low Grade Squamous Intraepithelial Lesion (LSIL (172 cases, 1.35%, High Grade Squamous Intraepithelial Lesion (HSIL (91 cases, 0.72% Squamous cell carcinoma (21cases, 0.17% Atypical Glandular Cells (AGC-NOS (53cases, 0.42% Atypical Glandular Cells - favor neoplastic (23 cases, 0.18% Endocervical adenocarcinoma in situ (01 case, 0.01% Endocervical adenocarcinoma (01 case, 0.01% Endometrial adenocarcinoma (19 cases, 0.15%. This study reveals the wide range of cervical epithelial cell abnormalities present in the population. The information provided in this study emphasizes the need for a national cervical screening program to estimate the actual magnitude of the problem, identify ‘at risk ’women and decrease the mortality from cervical cancer.

  4. MICROARRAY ANALYSIS OF DIFFERENT GENE EXPRESSION OF HUMAN CERVICAL CANCER SUBCLONE CELL LINES

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Cervical cancer is the main cause of death inwomen.The influence of HPV plays an i mportantrole incervial cancer.It has been provedthat humanpapillomavirus(HPV)infectionis ani mportant fac-tor in cervical carcinogenesis.Multiple HPVinfec-tion was associated less frequently with cervical car-cinoma and with precancerous lesions compared withnor mal cytology[1].The activation of oncogene,in-activition of tumor suppressor gene and instabilityof genome are also majority reason.We establisheda cell line of human...

  5. Cervical chondroid chordoma in a standard dachshund: a case report

    Directory of Open Access Journals (Sweden)

    Stigen Øyvind

    2011-10-01

    Full Text Available Abstract A ten-year-old male standard dachshund was presented with a history of neck pain and progressive gait disturbances. Following a neurological examination and diagnostic imaging, including CT, a neoplastic lesion involving the third and fourth cervical vertebrae was suspected. The lesion included an extradural mass on the right side of the spinal canal causing a local compression of the cervical cord. Surgery, using a modified dorsal laminectomy procedure, was performed in order to decompress the cervical spinal cord. Histopathological examination of the extradural mass indicated that the tumour was a chondroid chordoma. Following discharge, the quality of life for the dog was very good for a sustained period, but clinical signs recurred at 22 months. The dog was euthanased 25 months post-surgery. On post-mortem examination, a regrowth of neoplastic tissue was found to have infiltrated the bone and spinal cord at C3-C4. This is the first report to show that palliative surgery can offer successful long-lasting treatment of chondroid chordoma of the cervical spine in the dog.

  6. RESEARCH ON ABRASION OF DEBRIS FLOW TO HIGH-SPEED DRAINAGE STRUCTURE

    Institute of Scientific and Technical Information of China (English)

    陈洪凯; 唐红梅; 吴四飞

    2004-01-01

    As one weak topic in research of debris flow, abrasion of debris flow shortens obviously application life of control structure composed of concrete. High-speed drainage structure, one of the most effective techniques to control giant debris flow disaster, has shortened one-third application life due to abrasion by debris flow. Based on velocity calculation method founded by two-phase theory, research of abrasion mechanism of debris flow to high-speed drainage structure was made. The mechanism includes both abrasion mechanism of homogeneous sizing and shearing mechanism of particle of debris flow to high-speed drainage trough structure. Further abrasion equations of both sizing and particle were established by Newton movement theory of debris flow. And abrasion amount formula of the high-speed drainage trough structure is set up by dimensional analysis. Amount to calculating in the formula is consistent with testing data in-situ, which is valuable in design of high-speed drainage structure.

  7. The effect of hydrogen peroxide on polishing removal rate in CMP with various abrasives

    Science.gov (United States)

    Manivannan, R.; Ramanathan, S.

    2009-01-01

    The effect of hydrogen peroxide in chemical mechanical planarization slurries for shallow trench isolation was investigated. The various abrasives used in this study were ceria, silica, alumina, zirconia, titania, silicon carbide, and silicon nitride. Hydrogen peroxide suppresses the polishing of silicon dioxide and silicon nitride surfaces by ceria abrasives. The polishing performances of other abrasives were either unaffected or enhanced slightly with the addition of hydrogen peroxide. The ceria abrasives were treated with hydrogen peroxide, and the polishing of the work surfaces with the treated abrasive shows that the inhibiting action of hydrogen peroxide is reversible. It was found that the effect of hydrogen peroxide as an additive is a strong function of the nature of the abrasive particle.

  8. Control technology for crystalline silica exposures in construction: wet abrasive blasting.

    Science.gov (United States)

    Golla, Vijay; Heitbrink, William

    2004-03-01

    This study was designed to document the effect that wet abrasive blasting has on reducing worker exposure to crystalline silica, which has been associated with silicosis and premature death. In this study, worker exposure to respirable crystalline silica was monitored during wet abrasive blasting on the exterior walls of a parking garage to remove surface concrete and expose the underlying aggregate. In this process a wet sand mix comprised of 80% dry sand and 20% water was used. Sampling and analysis revealed that the geometric mean respirable quartz concentration was 0.2 mg/m(3) for workers conducting abrasive blasting and 0.06 mg/m(3) for helpers. When abrasive blasting was conducted in areas that apparently had reduced natural ventilation, dust exposures appeared to increase. When compared with other published data, this case study suggests that wet abrasive blasting causes less exposure to crystalline silica than dry abrasive blasting. PMID:15204868

  9. The Effect of Microstructure on the Abrasion Resistance of Low Alloyed Steels

    OpenAIRE

    Xu, X.

    2016-01-01

    The thesis attempts to develop advanced high abrasion resistant steels with low hardness in combination with good toughness, processability and low alloying additions. For this purpose, a novel multi-pass dual-indenter (MPDI) scratch test approach has been developed to approach the real continuous abrasion process and unravel abrasion damage formation in construction steels, i.e. carrying out scratch tests using a large indenter with different pre-loads to generate a wide pre-scratch with sta...

  10. Biologia molecular do câncer cervical Molecular biology of cervical cancer

    Directory of Open Access Journals (Sweden)

    Waldemar Augusto Rivoire

    2006-01-01

    Full Text Available A carcinogênese é um processo de múltiplas etapas. Alterações no equilíbrio citogenético ocorrem na transformação do epitélio normal a câncer cervical. Numerosos estudos apoiam a hipótese de que a infecção por HPV está associada com o desenvolvimento de alterações malignas e pré-malignas do trato genital inferior. Neste trabalho são apresentadas as bases para a compreensão da oncogênese cervical. O ciclo celular é controlado por proto-oncogenes e genes supressores. Quando ocorrem mutações, proto-oncogenes tornam-se oncogenes, que são carcinogênicos e causam multiplicação celular excessiva. A perda da ação de genes supressores funcionais pode levar a célula ao crescimento inadequado. O ciclo celular também pode ser alterado pela ação de vírus, entre eles o HPV (Human Papiloma Virus, de especial interesse na oncogênese cervical. Os tipos de HPV 16 e 18 são os de maior interesse, freqüentemente associados a câncer cervical e anal. O conhecimento das bases moleculares que estão envolvidas na oncogênese cervical tem sido possível devido a utilização de técnicas avançadas de biologia molecular. A associação destas técnicas aos métodos diagnósticos clássicos, poderão levar a uma melhor avaliação das neoplasias cervicais e auxiliar no desenvolvimento de novas terapias, talvez menos invasivas e mais efetivas.Carcinogenesis involves several steps. Disorders of the cytogenetic balance occur during the evolution from normal epithelium to cervical cancer. Several studies support the hypothesis that the Human Papiloma Virus (HPV infection is associated to development of premalignant and malignant lesions of cervical cancer. In this review we show the basis to understand cervical oncogenesis. The cell cycle is controlled by protooncogenes and supressive genes. This orchestrated cell cycle can be affected by virus such as HPV. Of special interest in the cervical carcinogenesis are the HPV subtypes 16 and 18

  11. Comparison of functional recovery of manual dexterity after unilateral spinal cord lesion or motor cortex lesion in adult macaque monkeys

    Directory of Open Access Journals (Sweden)

    Florence eHoogewoud

    2013-07-01

    Full Text Available In relation to mechanisms involved in functional recovery of manual dexterity from cervical cord injury or from motor cortical injury, our goal was to determine whether the movements that characterize post-lesion functional recovery are comparable to original movement patterns or do monkeys adopt distinct strategies to compensate the deficits depending on the type of lesion? To this aim, data derived from earlier studies, using a skilled finger task (the modified Brinkman board from which pellets are retrieved from vertical or horizontal slots, in spinal cord and motor cortex injured monkeys were analyzed and compared. Twelve adult macaque monkeys were subjected to a hemi-section of the cervical cord (n=6 or to a unilateral excitotoxic lesion of the hand representation in the primary motor cortex (n=6. In addition, in each subgroup, one half of monkeys (n=3 were treated for 30 days with a function blocking antibody against the neurite growth inhibitory protein Nogo-A, while the other half (n=3 represented control animals. The motor deficits, and the extent and time course of functional recovery were assessed.For some of the parameters investigated (wrist angle for horizontal slots and movement types distribution for vertical slots after cervical injury; movement types distribution for horizontal slots after motor cortex lesion, post-lesion restoration of the original movement patterns (true recovery led to a quantitatively better functional recovery. In the motor cortex lesion groups, pharmacological reversible inactivation experiments showed that the peri-lesion territory of the primary motor cortex or re-arranged, spared domain of the lesion zone, played a major role in the functional recovery, together with the ipsilesional intact premotor cortex.

  12. Prevent Cervical Cancer

    Science.gov (United States)

    ... Risk? What Are the Symptoms? What Should I Know About Screening? Statistics Related Links Inside Knowledge Campaign What CDC Is Doing Research AMIGAS Fighting Cervical Cancer Worldwide Stay Informed Printable Versions Standard quality PDF [PDF-877KB] High-quality PDF for professional ...

  13. Cervical silicone lymphadenopathy.

    Science.gov (United States)

    Gilbert, Latoni Kaysha; Thiruchelvam, Janavikulam

    2016-07-01

    A patient presented to the department of oral and maxillofacial surgery with a rare case of cervical silicone lymphadenopathy. She had a painless ovoid mass in the left side of her neck and had had cosmetic breast augmentation 10 years before. Radiological imaging and core biopsy examination were consistent with silicone lymphadenopathy. PMID:26830068

  14. Prevent Cervical Cancer!

    Centers for Disease Control (CDC) Podcasts

    2015-01-08

    Cervical cancer can be prevented. Listen as two friends—one a doctor—talk about screening tests and early detection. Learn what test you might need.  Created: 1/8/2015 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 1/8/2015.

  15. Evaluation of MCM-2 expression in TMA cervical specimens.

    Directory of Open Access Journals (Sweden)

    Alcina F Nicol

    Full Text Available BACKGROUND: Minichromosome maintenance proteins (MCM are highly expressed in actively replicating cells. The need for biological markers for cervical carcinoma and its precursor lesions is emerging. Our main aim was to determine the immunohistochemical expression of MCM-2 in HIV-positive and -negative dysplastic cervical specimens. METHODS: Immunohistochemical analysis of MCM-2 was performed in a total of 352 cervical TMA specimens of normal control, low-grade CIN, high-grade CIN and invasive tumor. 38 specimens were from HIV-positive women. A receiver operating characteristic (ROC curve was constructed to determine the best cutoff to diagnose high-grade CIN and invasive cervical cancer. RESULTS: In the progression from normal epithelium to high-grade CIN and invasive tumor we found significant differences in the MCM-2 expression (p<0.05. Based on the ROC curve of 80% with an area under the curve (AUC of 0.78, expression of MCM-2 to diagnose high-grade CIN and invasive tumor resulted in sensitivity of 81%, specificity of 66%, a positive predictive value (PPV of 86% and a negative predictive value (NPV of 57%. HIV-positive cervices revealed a decreasing expression of MCM-2 in both LGCIN and HGCIN compared with HIV-negative specimens (p<0.0001. CONCLUSIONS: The present study suggests that immunohistochemical MCM-2 may not be a promising biomarker for diagnosing high-grade CIN and invasive cancer.

  16. Cervical celullitis in broiler chickens for Escherichia coli/ Celulite cervical em frangos de corte causada por Escherichia coli

    Directory of Open Access Journals (Sweden)

    Ivens Gomes Guimarães

    2002-05-01

    Full Text Available In this paper was report the isolation of Escherichia coli in broiler chickens with cellulitis in the cervical region. It was carried through the isolation of E. coli of the lesion of cellulitis from broilers and carried through histopathological examination of skin that had characterized the lesion. Focal ulcerations of epidermis, fibrin in dermis and difuse infiltrated by lymphocytes and heterophils on subcutaneous tissues.Neste trabalho, relata-se o isolamento de Escherichia coli em frangos de corte apresentando lesão de celulite na região cervical. Foi realizado o isolamento de E. coli da lesão de celulite e realizado exames histopatológicos que caracterizaram a lesão. Na epiderme foram verificadas lesões ulcerativas, presença de fibrina na derme e infiltração difusa de linfócitos e heterófilos no tecido subcutâneo.

  17. Development of spent-control rod cutting equipment by abrasive water jet

    Energy Technology Data Exchange (ETDEWEB)

    Usui, Shinichi; Komiya, Toshihiro [Kawasaki Heavy Industries Ltd., Tokyo (Japan)

    2000-11-01

    Kawasaki Heavy Industries, Ltd. developed the cutting apparatus for spent-control rods and channel boxes, which utilized Abrasive Water Jet, and delivered them to Japan Atomic Power Company, Ltd. An abrasive water jet cutting is cutting method by abrasive ejecting with very high pressurized water (300 Mpa) and has merit not affecting to the objects thermally. The cutting operation carries out remotely in underwater and ejected abrasives are collected and reused in order to decrease secondary wastes. The spent-control rods and channel boxes are divided into two or three pieces and stored in the can in layers. (author)

  18. Radioactive labeling in the study of abrasion of hard tooth tissue

    International Nuclear Information System (INIS)

    Labeling the surface of hard tooth tissue samples by the nuclear recoil effect in radioactive decay was applied to study abrasion caused by abrasive components of tooth-pastes. 222Rn and its short-lived decay products were implanted into the surface in vacuum. For this purpose irradiation was applied to sample placed very close to thin 226Ra source. Measuring the activity before and after abrasion was used to evaluate abrasion in the system toothbrush - various suspensions of the tooth-pastes - hard tooth tissue (enamel or dentine) in a specially designed device, dentoabrasionmeter VUS 2. (author)

  19. HPV 16 E2 binding sites 1 and 2 become more methylated than E2 binding site 4 during cervical carcinogenesis.

    Science.gov (United States)

    Leung, Tsin-Wah; Liu, Stephanie S; Leung, Rebecca C Y; Chu, Mandy M Y; Cheung, Annie N Y; Ngan, Hextan Y S

    2015-06-01

    E2 protein binding to the four E2 binding sites (E2BSs) at the long control region of Human Papillomavirus (HPV) 16/18 genome may exert either transcriptional activation/repression on E6 and E7 oncoproteins. Methylation status at the E2BSs may affect the relative binding of E2 protein to them. In this study, methylation percentage at E2BS 1, 2 (promoter-proximal), and 4 (promoter-distal) were assessed by pyrosequencing and compared among HPV 16/18-positive cervical cancer, high-grade, and low-grade Cervical Intraepithelial Neoplasia, Atypical Squamous Cells of Undetermined Significance, and normal cervical epithelium. HPV 16 E2BS1&2 were more methylated than HPV 16 E2BS4 in cervical cancer whereas in cervical premalignant lesions and normal epithelium, HPV 16 E2BS1&2 were less methylated than HPV 16 E2BS4. HPV 18 E2BS1&2 remained more methylated than E2BS4 in all histological groups. HPV 16 E2BS1&2 methylation increased from high-grade lesions to cervical cancer (P E2 protein to E2BS4. Increasing methylation at HPV 16/18 E2BSs are potentially useful adjunctive molecular markers for predicting progression from low-grade to high-grade cervical premalignant lesions and from high-grade lesions to cervical cancer. PMID:25648229

  20. A mathematical model for electrochemical abrasive magnetic polishing operation

    International Nuclear Information System (INIS)

    In most reactions and metallurgical machining processes, it is essential on economic grounds to conserve energy requirements. The most important part of this energy is by hybrid conservation systems. Recently, for example as Magnetic- Abrasive - Electrolytic turning (MEAT) processes in the production of high surface quality by ultra precision machining. This technology combines many kinds of energy named hybrid processes, which satisfy both the metal removal efficiency and surface finishing for difficult-to-cut materials at the same time. In the present work, three stages of this process are studied and assessed. In the first stage, the metal removal by the electrochemical turning (ECT) is performed based on Faraday's laws. In this particular case, the different parameters that can affect ECT process such as the applied voltage and gap between the tool and the work-piece, the revolution speed, and the used type of electrolyte and flow rate, are studied and assessed. The author deduced a formula interpreting the relation between the electric conductivity and the process efficiency. Moreover, the relation between the above-mentioned parameter is correlated to the process efficiency. Unfortunately, an oxide membrane appears after some time which degrades the process efficiency. Therefore, in the second stage nonwoven abrasive pads can remove the oxide membrane. Two pad types are evaluated in this concern namely Aluminum oxide and Silicon carbide with different mesh cells are investigated in the abrasive-electrochemical process (AECT). In the third stage, applying a magnetic field can contribute in the oxide film destructions, leading to improving the magneto abrasive electrochemical process (MEAT) efficiency. The comparisons between ECM, AECM and MEAT processes show that average specific metal removal (Wm), are 0.5, 1.9, and 2.5 g/min.mm2.Amp, respectively. Meanwhile the process efficiencies are 1.18, 2.19, and 2.74, respectively. Therefore, the results of the present

  1. Simulation of abrasive water jet cutting process - Part 2

    OpenAIRE

    Junkar, Mihael; Orbanić, Henri

    2015-01-01

    A new two-dimensional cellular automata (CA) model for the simulation of the abrasive water jet (AWJ) cutting process is presented. The CA calculates the shape of the cutting front, which can be used as an estimation of the surface quality. The cutting front is formed based on material removal rules and AWJ propagation rules. The material removal rule calculates when a particular partof the material will be removed with regard to the energy of AWJ. The AWJ propagation rule calculates the dist...

  2. Some results of tangential turning with an abrasive water jet

    Czech Academy of Sciences Publication Activity Database

    Cárach, J.; Hlaváček, Petr; Vasilko, K.; Klich, Jiří; Hloch, Sergej

    Prešov: Technická univerzita v Košicích se sídlem v Prešově, 2013 - (Lehocká, D.; Cárach, J.; Knapčíková, L.; Hloch, S.), s. 350-354. (TEAM). ISSN 1847-9065. [International Scientific and Expert Conference of the International TEAM Society (Technique, Education, Agriculture & Management ) /5./. Prešov (SK), 04.11.2013-06.11.2013] R&D Projects: GA MŠk ED2.1.00/03.0082 Institutional support: RVO:68145535 Keywords : turning * abrasive water jet * rotation * workpiece * sandstone Subject RIV: JQ - Machines ; Tools

  3. Testing of Commercial Cutting Heads for Abrasive Water Jet Technology

    Czech Academy of Sciences Publication Activity Database

    Klich, Jiří; Hlaváček, Petr; Zeleňák, Michal; Sitek, Libor; Foldyna, Josef

    Zagreb : Croatian Assossiation of Production Engineering , 2013 - (Abele, E.; Udiljak, T.; Ciglar, D.), s. 149-154 ISBN 978-953-7689-02-5. [CIM 2013 Computer Integrated Manufacturing and High Speed Maching. Biograd (HR), 19.06.2013-22.06.2013] R&D Projects: GA MŠk ED2.1.00/03.0082; GA MPO FR-TI3/733 Institutional support: RVO:68145535 Keywords : high-speed abrasive water jet technology * cutting head * cutting ability Subject RIV: JQ - Machines ; Tools

  4. Metal sealed cone bits reduce costs in abrasive drilling

    International Nuclear Information System (INIS)

    This paper reports on metal sealed rolling cone bits, which have cut drilling cost by increasing the footage drilled per bit and by increasing the penetration rate in several wells in South America. The metal seals double the bearing life compared to conventional elastomer sealed bits, thereby allowing the bit to stay on bottom longer. In Colombia, and operator required that only one bit be used to drill an entire section of hard, abrasive sandstone. In Venezuela, metal sealed bits were used to lower drilling costs in both relatively moderate and aggressive drilling conditions

  5. Monitoring and control of fine abrasive finishing processes

    DEFF Research Database (Denmark)

    Lazarev, Ruslan

    In engineering, surfaces with specified functional properties are of high demand in various applications. Desired surface finish can be obtained using several methods. Abrasive finishing is one of the most important processes in the manufacturing of mould and dies tools. It is a principal method to...... remove unwanted material, obtain desired geometry, surface quality and surface functional properties. The automation and computerization of finishing processes involves utilisation of robots, specialized machines with several degrees of freedom, sensors and data acquisition systems. The focus of this...

  6. Differences in human papillomavirus type distribution in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe

    DEFF Research Database (Denmark)

    Tjalma, Wiebren A; Fiander, Alison; Reich, Olaf;

    2013-01-01

    Knowledge of differences in human papillomavirus (HPV)-type prevalence between high-grade cervical intraepithelial neoplasia (HG-CIN) and invasive cervical cancer (ICC) is crucial for understanding the natural history of HPV-infected cervical lesions and the potential impact of HPV vaccination...... on cervical cancer prevention. More than 6,000 women diagnosed with HG-CIN or ICC from 17 European countries were enrolled in two parallel cross-sectional studies (108288/108290). Centralised histopathology review and standardised HPV-DNA typing were applied to formalin-fixed paraffin-embedded cervical...... common HPV types in women with HG-CIN were HPV16/33/31 (59.9/10.5/9.0%) and in ICC were HPV16/18/45 (63.3/15.2/5.3%). In squamous cell carcinomas, HPV16/18/33 were most frequent (66.2/10.8/5.3%), and in adenocarcinomas, HPV16/18/45 (54.2/40.4/8.3%). The prevalence of HPV16/18/45 was 1.1/3.5/2.5 times...

  7. Cervical pap smear study and its utility in cancer screening to specify the strategy for cervical cancer control

    Directory of Open Access Journals (Sweden)

    Mandakini M Patel, Amrish N Pandya, Jigna Modi

    2011-01-01

    Full Text Available The study was conducted to explore various lesions of Uterine cervix [inflammatory and growth], to find out target age group in which screening efforts can be concentrated for early detection as well as reduction of the incidence of cervical cancer, in our set up. Patients in the age group 15-50 and 50-78 years with various complaints were screened during June 2006 to December 2007. Total 995 patients were studied. Slides were fixed in 95% ethyl alcohol and stained with Pap stain. Slides were reported according to The 2001 Bethesda System, by cytopathologists. Out of 995 patients studied, 940 showed inflammation and other benign lesions. 55 patients showed premalignant and malignant lesions. Premalignant lesions were present in 30-50 year of age group.

  8. Prevalence of human papillomavirus in abnormal cervical smears in Malaysian patients.

    Science.gov (United States)

    Sharifah, Noor Akmal; Seeni, A; Nurismah, M I; Clarence-Ko, C H; Hatta, A Z; Ho, Ng-Paul; Rafaee, T; Adeeb, N; Jamal, R

    2009-01-01

    Cervical cancer is the second most common female malignancy in Malaysia. Despite advances in treatment, the overall survival for this disease has not changed in the last decade. Infection by certain types of HPV is recognized as a causal and necessary factor for its development. This study was carried out to determine the prevalence of HPV infection in abnormal cervical smears in Malaysian patients using archival cervical smears retrieved from the Cytopathology Unit, Universiti Kebangsaan Malaysia Medical Centre (UKMMC) between the years 1992-1995. DNA was extracted from 38 abnormal smears comprising 25 intraepithelial lesions and 13 cervical carcinomas and 10 normal smears. Amplification of HPV genes was carried out using the polymerase chain reaction (PCR) technique. HPV genotypes were determined using direct sequencing and the results were compared to the database from Genebank. DNA was successfully extracted from all 48 cervical smears. High-risk HPV (HR-HPV) genotypes were detected in 95% of the abnormal smears. Eight high-risk oncogenic types were identified: 16, 18, 31, 51, 52, 56, 58 and 66. All (100%) cervical cancer smears showed presence of HR-HPV compared to 92% of the cervical intraepithelial lesions. Among the eight HR-HPV genotypes identified, HPV 16 and 52 were the commonest (23.7% each) HPV genotypes encountered and among the CIN lesions, HPV 16 (28%) was the most frequent. We conclude that HPV 16 is the most prevalent HPV genotype present in abnormal cervical smears in Malaysian patients, and that the use of archival material to assess the presence of HPV is potentially worthwhile, and can be utilized for longitudinal studies of HPV presence and persistence. PMID:19537900

  9. Cervical spinal canal narrowing and cervical neurologi-cal injuries

    OpenAIRE

    Zhang, Ling; Chen, Hai-Bin; Wang, Yi; ZHANG Li-ying; Liu, Jing-cheng; WANG Zheng-guo

    2012-01-01

    【Abstract】Cervical spinal canal narrowing can lead to injury of the spinal cord and neurological symptoms in-cluding neck pain, headache, weakness and parasthesisas. According to previous and recent clinical researches, we investigated the geometric parameters of normal cervical spinal canal including the sagittal and transverse diameters as well as Torg ratio. The mean sagittal diameter of cervical spinal canal at C 1 to C 7 ranges from 15.33 mm to 20.46 mm, ...

  10. Assessment of quality of life for the patients with cervical cancer at different clinical stages

    Directory of Open Access Journals (Sweden)

    Chun-Xia Yang

    2013-05-01

    Full Text Available With improved overall survival of cervical cancer patients, the importance of the quality of life (QOL is increasingly recognized. This study was conducted to compare the QOL of women with different stage cervical cancer before and after treatment to facilitate improved cervical cancer prevention and treatment. We used the generic Medical Outcomes Study Short Form-36 (MOS SF-36 to collect QOL information. Based on SF-36, we interviewed cervical cancer patients at West China Second Affiliated Hospital and Sichuan Cancer Hospital between May 2010 and January 2011. A total of 92 patients with precancerous lesions, 93 with early cancer, and 35 with advanced cancer responded to our survey. Average physical component summary (PCS scores were significantly different between the three groups at every time point (P < 0.05. Average mental component summary (MCS scores were significantly different between the three groups after treatment (P < 0.05. Average PCS and MCS scores increased gradually from the pretreatment to posttreatment period for patients with precancerous lesions. However, they reached the lowest at 1 month after treatment for patients with early and advanced cancers and rebounded between 1 and 6 months after treatment. Our results indicate that patients with precancerous lesions and early cervical cancer show better overall QOL than do those with advanced cervical cancer. Additionally, patients with early cancer recover more quickly than do those with advanced cancer in terms of both physical and mental functions. Thus, early detection and treatment initiatives may improve the QOL for patients with precancerous lesions and cervical cancer.

  11. Assessment of quality of life for the patients with cervical cancer at different clinical stages

    Institute of Scientific and Technical Information of China (English)

    Yao Xie; Fang-Hui Zhao; Si-Han Lu; He Huang; Xiong-Fei Pan; Chun-Xia Yang; You-Lin Qiao

    2013-01-01

    With improved overall survival of cervical cancer patients,the importance of the quality of life (QOL)is increasingly recognized.This study was conducted to compare the QOL of women with different stage cervical cancer before and after treatment to facilitate improved cervical cancer prevention and treatment.We used the generic Medical Outcomes Study Short Form-36 (MOS SF-36) to collect QOL information.Based on SF-36,we interviewed cervical cancer patients at West China Second Affiliated Hospital and Sichuan Cancer Hospital between May 2010 and January 2011.A total of 92 patients with precancerous lesions,93 with early cancer,and 35 with advanced cancer responded to our survey.Average physical component summary (PCS) scores were significantly different between the three groups at every time point (P < 0.05).Average mental component summary (MCS) scores were significantly different between the three groups after treatment (P < 0.05).Average PCS and MCS scores increased gradually from the pretreatment to posttreatment period for patients with precancerous lesions.However,they reached the lowest at 1 month after treatment for patients with early and advanced cancers and rebounded between 1and 6 months after treatment.Our results indicate that patients with precancerous lesions and early cervical cancer show better overall QOL than do those with advanced cervical cancer.Additionally,patients with early cancer recover more quickly than do those with advanced cancer in terms of both physical and mental functions.Thus,early detection and treatment initiatives may improve the QOL for patients with precancerous lesions and cervical cancer.

  12. STUDY OF HIGH RISK CASES FOR EARLY DETECTION OF CERVICAL CANCER BY PAP’S SMEAR AND VISUAL INSPECTION BY LUGOL’S IODINE METHOD.

    OpenAIRE

    Harshad Ladola; Ami Mehta; Kamlesh Kotadiya; Rebecca Edwin; Vibhuti Patel; Vaibhavi Patel

    2013-01-01

    INTRODUCTION:Cervical cancer is the commonest genital tract cancer among Indian women. Screening programmes have claimed to reduce incidence and mortality of cervical carcinoma significantly, for which sensitization of women is required through community based approach.OBJECTIVES: Comparison of VILI and cytology by PAP smear for detection of low grade squamous intraepithelial lesion, high grade squamous intraepithelial lesion, carcinoma of cervix and correlation of results with the reference ...

  13. Three-Body Abrasion Testing Using Lunar Dust Simulants to Evaluate Surface System Materials

    Science.gov (United States)

    Kobrick, Ryan L.; Budinski, Kenneth G.; Street, Kenneth W., Jr.; Klaus, David M.

    2010-01-01

    Numerous unexpected operational issues relating to the abrasive nature of lunar dust, such as scratched visors and spacesuit pressure seal leaks, were encountered during the Apollo missions. To avoid reoccurrence of these unexpected detrimental equipment problems on future missions to the Moon, a series of two- and three-body abrasion tests were developed and conducted in order to begin rigorously characterizing the effect of lunar dust abrasiveness on candidate surface system materials. Two-body scratch tests were initially performed to examine fundamental interactions of a single particle on a flat surface. These simple and robust tests were used to establish standardized measurement techniques for quantifying controlled volumetric wear. Subsequent efforts described in the paper involved three-body abrasion testing designed to be more representative of actual lunar interactions. For these tests, a new tribotester was developed to expose samples to a variety of industrial abrasives and lunar simulants. The work discussed in this paper describes the three-body hardware setup consisting of a rotating rubber wheel that applies a load on a specimen as a loose abrasive is fed into the system. The test methodology is based on ASTM International (ASTM) B611, except it does not mix water with the abrasive. All tests were run under identical conditions. Abraded material specimens included poly(methyl methacrylate) (PMMA), hardened 1045 steel, 6061-T6 aluminum (Al) and 1018 steel. Abrasives included lunar mare simulant JSC- 1A-F (nominal size distribution), sieved JSC-1A-F (materials of aluminum and PMMA. The nominal JSC- 1A-F consistently showed more abrasion wear than the sieved version of the simulant. The lunar dust displayed abrasivity to all of the test materials, which are likely to be used in lunar landing equipment. Based on this test experience and pilot results obtained, recommendations are made for systematic abrasion testing of candidate materials intended for

  14. Treatment Options by Stage (Cervical Cancer)

    Science.gov (United States)

    ... Cancer Prevention Cervical Cancer Screening Research Cervical Cancer Treatment (PDQ®)–Patient Version General Information About Cervical Cancer ... Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery) depends on ...

  15. Cervical Cancer Rates by Race and Ethnicity

    Science.gov (United States)

    ... Associated Lung Ovarian Prostate Skin Uterine Cancer Home Cervical Cancer Rates by Race and Ethnicity Language: English Español ( ... Tweet Share Compartir The rate of women getting cervical cancer or dying from cervical cancer varies by race ...

  16. Separation of Normal and Premalignant Cervical Epithelial Cells Using Confocal Light Absorption and Scattering Spectroscopic Microscopy Ex Vivo

    Directory of Open Access Journals (Sweden)

    Ling Yang

    2011-01-01

    Full Text Available Confocal light absorption and scattering spectroscopic (CLASS microscopy can detect changes in biochemicals and the morphology of cells. It is therefore used to detect high-grade cervical squamous intraepithelial lesion (HSIL cells in the diagnosis of premalignant cervical lesions. Forty cervical samples from women with abnormal Pap smear test results were collected, and twenty cases were diagnosed as HSIL; the rest were normal or low-grade cervical squamous intraepithelial lesion (LSIL. The enlarged and condensed nuclei of HSIL cells as viewed under CLASS microscopy were much brighter and bigger than those of non-HSIL cells. Cytological elastic scattered light data was then collected at wavelengths between 400 and 1000 nm. Between 600 nm to 800 nm, the relative elastic scattered light intensity of HSIL cells was higher than that of the non-HSIL. Relative intensity peaks occurred at 700 nm and 800 nm. CLASS sensitivity and specificity results for HSIL and non-HSIL compared to cytology diagnoses were 80% and 90%, respectively. This study demonstrated that CLASS microscopy could effectively detect cervical precancerous lesions. Further study will verify this conclusion before the method is used in clinic for early detection of cervical cancer.

  17. New decontamination techniques: chemical gels, electropolishing and abrasives

    International Nuclear Information System (INIS)

    The decommissioning of nuclear installations requires decontamination techniques that are efficient, simple to apply and producing a small amount of wastes, which are easy to process. With a view to this, three decontamination methods, which appear to be particularly suited to decommissioning, have been studied. These three methods are: - spraying of gels carrying chemical decontaminating agents, - electropolishing with a swab device, - abrasives blasting. After parametric tests on non-radioactive and active samples, the industrial application of these methods in the dismantling of installations was studied. These industrial applications concern: - decontamination of pieces coming from the German BWR ISAR by immersion and gel spraying, - decontamination, mainly by gel spraying, and dismantling of the BRENNILIS bituminisation plant, - decontamination of part of the cooling circuit of the graphite gas reactor G2 by gel spraying, - decontamination of a component of the FBR SuperPhenix, using dry abrasives blasting. During the first three applications, generated secondary wastes volume and form were determined. 33 tabs., 16 figs., 12 refs

  18. Shrinkage, abrasion, erosion and sorption of clay plasters

    Directory of Open Access Journals (Sweden)

    Minke, G.

    2011-09-01

    Full Text Available At the Buildung Research Institute (FEB, Faculty of Architecture, University of Kassel, Germany, in the last years several hundred tests were made to study the characteristics of different loam mortars in respect of their linear shrinkage, absorption of humidity and their resistance against abrasion and erosion. In order to get data about abrasion and erosion new test methods and special apparatusses were developed. The mortars tested, chosen from the market, showed extremely varying test results.

    En el Laboratorio de Construcciones Experimentales (FEB de la Facultad de Arquitectura, Universidad de Kassel, Alemania, fueron testeados cientos de diferentes pruebas de revoque de barro para estudiar su contracción durante el secado, su absorción de humedad y su resistencia contra abrasión, erosión y absorción. Para recibir datos sobre abrasión y erosión, nuevas aparatos y metodos fueron desarrollados. Los resultados de los revoques comprados en el mercado muestran gran diferencias en los valores.

  19. Study on mineral processing technology for abrasive minerals

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Seong Woong; Yang, Jung Il; Hwang, Seon Kook; Choi, Yeon Ho; Cho, Ken Joon; Shin, Hee Young [Korea Inst. of Geology Mining and Materials, Taejon (Korea, Republic of)

    1995-12-01

    Buyeo Materials in Buyeogun, Choongnam province is a company producing feldspar concentrate, but does not yet utilize the garnet as abrasive material and other useful heavy minerals wasted out from the process of feldspar ore. The purpose of this study is to develop technology and process for the recovery of garnet concentrate. As results, the garnet is defined as ferro manganese garnet. The optimum process for recovery of garnet concentrate is to primarily concentrate heavy minerals from tailings of feldspar processing. And secondly the heavy minerals concentrated is dried and separated garnet concentrate from other heavy minerals. At this time, the garnet concentrate is yield by 0.176%wt from 0.31%wt of heavy minerals in head ore. The garnet concentrate contains 33.35% SiO{sub 2}, 12.20% Al{sub 2}O{sub 3}, 28.47% Fe{sub 2}O{sub 3}, 11.96% MnO. As for utilization of abrasive materials, a fundamental data was established on technology of grinding and classification. (author). 13 refs., 47 figs., 24 tabs.

  20. Polyurethanes from the crystalline prepolymers resistant to abrasive wear

    Directory of Open Access Journals (Sweden)

    Domańska Agata

    2014-12-01

    Full Text Available The research aimed at the selection of polyurethanes synthesized from poly(tetramethylene ether glycol (PTMEG, as well as from two different isocyanates 4,4′-methylenebis(cyclohexylisocyanate (HMDI and 4.4′-methylenebis(phenyl isocyanate (MDI in order to obtain polyurethane with increased resistance to abrasive wear and degradation for bio-medical application. Polyurethanes were fabricated from crystalline prepolymers extended by water. The paper presents preliminary results on polyurethane surface wettability, friction coefficient for different couples of the co-working materials such as polyurethane-polyurethane, polyurethane-titanium alloy, polyurethane-alumina, in comparison to commonly used polyethylene-titanium alloy. Shear strength of polyurethane-alumina joint, as well as viscosity of prepolymers were also measured. The values of friction coefficient were compared to literature data on commercially available polyurethane with the trade name Pellethane. Polyurethanes obtained are characterized by low abrasive wear and low friction coefficient in couple with the titanium alloy, what makes them attractive as possible components of ceramic-polymer endoprosthesis joints.