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Sample records for cerebral infarction

  1. Digital subtraction angiography in cerebral infarction

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    Cho, Sin Young; Kim, Ji Hun; Suh, Hong Kil; Kim, Hyo Heon; Kwack, Eun Young; Lee, Il Seong [College of Medicine Hallym University, Seoul (Korea, Republic of)

    1995-01-15

    The usefulness and radiographic findings of the angiography in cerebral infarction are well known. We attempted to evaluate the angiographic causes, findings, and the usefulness of DSA in cerebral infarction. The authors reviewed retrospectively DSA images of 51 patients who were diagnosed as having cerebral infarction by brain CT and/or MRI and clinical settings. DSA was performed in all 51 patients, and in 3 patients, conventional angiogram was also done. Both carotid DSA images were obtained in AP, lateral, oblique projections, and one or both vertebral DSA images in AP and lateral. The authors reviewed the patient's charts for symptoms, operative findings and final diagnosis, and analysed DSA findings of cerebral atherosclerosis with focus on 6 major cerebral arteries. Among the 51 patients of cerebral infarction 43 patients (84.3%) had cerebral atherosclerosis, 1 dissecting aneurysm, 1 moyamoya disease and 6 negative in angiogram. DSA findings of cerebral atherosclerosis were multiple narrowing in 42 patients (97.7%), tortuosity in 22 (51.2%), dilatation in 14, occlusion in 12, avascular region in 8, collaterals in 7, ulcer in 6, and delayed washout of contrast media in 3. In cerebral atherosclerosis, internal carotid artery was involved in 37 patients (86.0%), middle cerebral artery in 29 (67.4%) posterior cerebral artery in 28, anterior cerebral artery in 26, vertebral artery in 22, and basilar artery in 15. Intracranial involvement of cerebral atherosclerosis (64.9%) was more common than extracranial involvement (16.2%). In cerebral infarction MRA may be the screening test, but for more precise evaluation of vascular abnormality and its extent, DSA should be considered.

  2. Multiorgan with renal infarction following treatment of cerebral infarction.

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    Kim, Ji Hee; Kang, Chung; Moon, Hyo Jeong; Joo, Min Cheol

    2013-08-01

    Acute renal infarction is a rare disease and it is often difficult to make a clinical diagnosis due to the non-specific clinical presentations and lack of the physicians' awarenesses. We experienced a case of a 72-year-old man who was diagnosed as multiorgan with renal infarction during the bridge therapy of cerebral infarction with atrial fibrillation. Computed tomogram (CT) with intravenous contrast of the abdomen and pelvis revealed left renal infarction with renal artery occlusion, multifocal splenic infarction, and ischemic colitis on rectum and sigmoid colon. The patient was treated with low molecular weight heparin for 10 days, his symptoms were improved and laboratory findings were normalized. Follow-up CT was performed on the 43th day, there were persisted left renal infarction with atrophic change shown and the splenic perfusion was improved.

  3. Locations of cerebral infarctions in tuberculous meningitis

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    Hsieh, F.Y.; Chia, L.G. (Section of Neurology, Taichung Veterans General Hospital (Taiwan)); Shen, W.C. (Section of Neuroradiology, Taichung Veterans General Hospital (Taiwan))

    1992-06-01

    The locations of cerebral infarctions were studied in 14 patients with tuberculous meningitis (TBM) and 173 patients with noninflammatory ischemic stroke (IS). In patients with TBM, 75% of infarctions occurred in the 'TB zone' supplied by medial striate and thalamoperforating arteries; only 11% occurred in the 'IS zone' supplied by lateral striate, anterior choroidal and thalamogeniculate arteries. In patients with IS, 29% of infarctions occurred in the IS zone, 29% in the subcortical white matter, and 24% in (or involving) the cerebral cortex. Only 11% occurred in the TB zone. Bilaterally symmetrical infarctions of the TB zone were common with TBM (71%) but rare with IS (5%). (orig.).

  4. Clinical significance of urine ferritin in patients with cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    周慧

    2013-01-01

    Objective To find an indicator in urine to assist diagnosis of cerebral infarction,we investigated the changes of urine ferritin in patients with cerebral infarction.Methods Collected serum from 30 healthy volunteers and 53 patients with cerebral infarction (CI) ,with ratio ofmales to females

  5. Myocardial infarction and cerebral infarction in a Danish suburban community

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    Lyngborg, K; Marquardsen, J; Trautner, F

    1985-01-01

    A comparison was made of 485 cases of cerebral infarction (CI), registered prospectively in Frederiksberg, Copenhagen, with 495 cases of myocardial infarction (AMI), recorded retrospectively in the same population. The overall annual incidence of AMI was 6.5 per 1,000 population for males, 3...... with advancing age; for each sex and diagnosis the relationship can thus be expressed as a simple mathematical formula, which may facilitate comparisons of incidence patterns in different communities. Theories explaining the similarities and differences of the age-incidence curves for AMI and CI are discussed....

  6. Hypereosinophilia with Multiple Thromboembolic Cerebral Infarcts and Focal Intracerebral Hemorrhage

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    Lee, Eun Ju; Lee, Young Jun; Lee, Seung Ro; Park, Dong Woo; Kim, Hyun Young [Hanyang University College of Medicine, Seoul (Korea, Republic of)

    2009-10-15

    We report a case of hypereosinophilia causing multiple areas of cerebral infarcts. A 52-year-old Korean man presented with dysarthria and weakness in both arms. A brain MRI revealed multiple acute infarcts in the distal border zone with focal intracerebral hemorrhage, whereas a cerebral angiogram was not remarkable. The eosinophil count was 5,500/{mu}L and was accompanied by elevated cardiac enzyme levels. The pattern of cerebral infarcts and laboratory results suggest a thromboembolic infarction associated with hypereosinophilia.

  7. Perfusion Pressure Cerebral Infarct (PPCI) trial

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    Vedel, Anne G.; Holmgaard, Frederik; Rasmussen, Lars Simon

    2016-01-01

    to be caused by emboli, but inadequate blood flow caused by other mechanisms may increase ischaemia in the penumbra or cause watershed infarcts. During cardiopulmonary bypass, blood pressure can be below the lower limit of cerebral autoregulation. Although much debated, the constant blood flow provided...... by the cardiopulmonary bypass system is still considered by many as appropriate to avoid cerebral ischaemia despite the low blood pressure. Methods/design: The Perfusion Pressure Cerebral Infarct trial is a single-centre superiority trial with a blinded outcome assessment. The trial is randomising 210 patients...... with coronary vessel and/or valve disease and who are undergoing cardiac surgery with the use of cardiopulmonary bypass. Patients are stratified by age and surgical procedure and are randomised 1:1 to either an increased mean arterial pressure (70–80 mmHg) or ‘usual practice’ (40–50 mmHg) during cardiopulmonary...

  8. Recirculation usually precedes malignant edema in middle cerebral artery infarcts

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    Nielsen, T H; Ståhl, N; Schalén, W;

    2012-01-01

    In patients with large middle cerebral artery (MCA) infarcts, maximum brain swelling leading to cerebral herniation and death usually occurs 2-5 days after onset of stroke. The study aimed at exploring the pattern of compounds related to cerebral energy metabolism in infarcted brain tissue....

  9. Bilateral cerebral hemispheric infarction associated with sildenafil citrate (Viagra) use.

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    Kim, K-K; Kim, D G; Ku, Y H; Lee, Y J; Kim, W-C; Kim, O J; Kim, H S

    2008-03-01

    Sildenafil citrate (Viagra) is one of the frequently prescribed drugs for men with erectile dysfunction. We describe a 52-year-old man with bilateral middle cerebral artery (MCA) territory infarction after sildenafil use. He ingested 100 mg of sildenafil and about 1 h later, he complained of chest discomfort, palpitation and dizziness followed by mental obtundation, global aphasia and left hemiparesis. Brain magnetic resonance imaging documented acute bilateral hemispheric infarction, and cerebral angiography showed occluded bilateral MCA. Despite significant bilateral MCA stenosis and cerebral infarction, systemic hypotension persisted for a day. We presume that cerebral infarction was caused by cardioembolism with sildenafil use.

  10. Cerebral infarction in patient with minimal change nephrotic syndrome.

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    Babu, A; Boddana, P; Robson, S; Ludeman, L

    2013-01-01

    We report a case of 68-year-old Caucasian man who presented with cerebral infarcts secondary to arterial thrombosis associated with nephrotic syndrome. His initial presentation included edema of legs, left hemiparesis, and right-sided cerebellar signs. Investigations with computed tomography and magnetic resonance imaging of brain showed multiple cerebral infarcts in middle cerebral and posterior cerebral artery territory. Blood and urine investigations also showed impaired renal function, hypercholesterolemia, hypoalbuminaemia, and nephrotic range proteinuria. Renal biopsy showed minimal change disease. Cerebral infarcts were treated with antiplatelet agents and nephrotic syndrome was treated with high dose steroids. Patient responded well to the treatment and is all well till date.

  11. Electrocardiogram changes in acute cerebral infarction patients

    Institute of Scientific and Technical Information of China (English)

    Jing Fang; Weihong Yan

    2006-01-01

    BACKGROUND: Comparison of different stroke locations had been focused in past researches in electrocardiogram (ECG) changes of cerebral stroke patients. Some researches neglected the heart disease in the illness history.OBJECTIVE: To discuss ECG changes in different infarction locations and size of acute cerebral infarction and compare with healthy people.DESIGN: Contrast observation.SETrING: Shanghai Ninth People's Hospital.PARTICIPANTS: A total of 57 patients with cerebral infarction were selected from the Neurological Department of Ninth People's Hospital of Shanghai from March 2003 to September 2005. They were diagnosed according to the criteria revised in the 4th National Cerebral Disease Conference and brain images. Patients who had heart disease were excluded. There were 32 males and 25 females, who were 65-84 years old. Among them, 23 cases were involved in right hemisphere, 34 cases in left one, 23 in base ganglion, 11 in brain stem, 9in frontal lobe and 14 in other parts. According to their infarction size (plus size in every different scan), they were divided into three different groups: large-size group (n = 10) with size larger than 3.5 cm3, medium-sizegroup (n = 13) with size between 1.5-3.5 cm3, and small-size group (n = 34) with size smaller than 1.5 cm3.Another 50 healthy subjects were regarded as control group. There were 29 males and 21 females aged 40-82 years. All these cases knew and agreed of the examination.METHODS: Patients received 12-lead ECG examinations within the first 6-24 hours of onset while control group received it at the same time. The HR, PR, QTc, QRS, T wave and ST changes were compared between the two groups.MAIN OUTCOME MEASURES: The ECG changes and differences in two hemispheres, in different infarction lccations and sizes. RESULTS: All 57 patients and 50 healthy subjects were involved in the final analysis. ① ECG changes in infarction group and control group. There were no differences in HR, QRS time and cases with

  12. CORRELATION BETWEEN FIBRINOGEN LEVEL AND CEREBRAL INFARCTION

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    Yi-cheng Zhu; Li-ying Cui; Bao-lai Hua; Jia-qi Pan

    2006-01-01

    Objective To investigate the correlation between plasma fibrinogen level and cerebral infarction (CI) as well as the difference of fibrinogen among subtypes of CI.Methods A case-controlled study was conducted with 131 cases of CI and 148 controls. Plasma fibrinogen levels were detected by the Clauss method.Results High fibrinogen level (3.09±0.94 g/L) was correlated with CI (OR=2.47, 95% CI:1.51-4.04,P<0.005) at the onset stage of the disease. Persistent high fibrinogen level (3.14±0.81 g/L) at 6-month after stroke onset was detected and correlated with CI (OR=4.34, 95% CI: 1.80-10. 51,P=0.001). Higher fibrinogen level was correlated with total anterior circulation infarction (TACI), partial anterior circulation infarction (PACI), and posterior circulation infarction (POCI) (OR = 4.008, P<0.001). Higher fibrinogen level was correlated with extracranial atherosclerosis (OR=3.220, P<0.05), but not with intracranial atherosclerosis.Conclusion Fibrinogen level may be a risk factor of CI and probably correlates with subtypes of CI and distributions of atherosclerosis.

  13. Cerebral infarctions due to CNS infection with Enterobacter sakazakii

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    Gallagher, P.G. (Cincinnati Univ., OH (USA). Dept. of Pediatrics Children' s Hospital Medical Center, Cincinnati, OH (USA)); Ball, W.S. (Cincinnati Univ., OH (USA). Dept. of Radiology Children' s Hospital Medical Center, Cincinnati, OH (USA))

    1991-02-01

    Recent reports have implicated Enterobacter sakazakii, a gram-negative enteric bacillus, in neonatal sepsis and meningitis. Cases of severe central nervous system involvement, including ventriculitis, brain abscess, infarction, and cyst formation, have been described. We present serial head CT findings in a case of neonatal E. sakazakii meningitis complicated by a ring enhancing cerebral infarction which mimicked abscess formation. In meningitis secondary to this agent, a recognized pattern of cerebral hypodensity with or without cystic degeneration late in the course of the infection is likely to represent cerebral infarction rather than an abscess especially if there is a lack of culture evidence of a bacterial infection. (orig.).

  14. [Cerebral infarction and transient ischemic attack].

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    Sahara, Noriyuki; Kuwashiro, Takahiro; Okada, Yasushi

    2016-04-01

    Japanese Guidelines for the Management of Stroke 2015 was published. Here, we describe several points revised from the 2009 edition about "Cerebral infarction and transient ischemic attack (TIA)". The revision points are as follows; 1. Extension of possible time window of intravenous recombinant tissue-plasminogen activator treatment (from within 3 hours to within 4.5 hours); 2. Antiplatelet therapy in acute stage (dual antiplatelet therapy (DAPT) for non-cardioembolic ischemic stroke or TIA); 3. Endovascular recanalization therapy in acute stage; 4. Antiplatelet therapy in chronic stage (Cilostazol is recommended similar to aspirin or clopidogrel); 5. Non-vitamin K antagonist oral anticoagulants (NOACs) for non-valvular atrial fibrillation (NVAF) stroke or TIA patients; 6. Management of TIA. We explain the revised points of the guideline in the text.

  15. A schizophrenic patient with cerebral infarctions after hemorrhagic shock

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    Youichi Yanagawa

    2013-01-01

    Full Text Available We herein report the fourth case of cerebral infarction, concomitant with hemorrhagic shock, in English literature. A 33-year-old male, who had been diagnosed with schizophrenia and given a prescription for Olanzapine, was discovered with multiple self-inflicted bleeding cuts on his wrist. On arrival, he was in hemorrhagic shock without verbal responsiveness, but his vital signs were normalized following infusion of Lactate Ringer′s solution. The neuroradiological studies revealed multiple cerebral ischemic lesions without any vascular abnormality. He was diagnosed with speech apraxia, motor aphasia, and dysgraphia, due to multiple cerebral infarctions. As there was no obvious causative factor with regard to the occurrence of cerebral infarction in the patient, the hypoperfusion due to hemorrhagic shock, and the thromboembolic tendency due to Olanzapine, might have acted together to lead to the patient′s cerebral ischemia.

  16. Enlarged perivascular spaces and lacunar infarction Cerebral magnetic resonance evaluation

    Institute of Scientific and Technical Information of China (English)

    Weihong Yan; Jing Fang; Cuijuan Zhou

    2008-01-01

    BACKGROUND:Previous studies have demonstrated that enlarged perivascular spaces(EPVS)arg a result of microvaseular disease.To date,there age few reports about the relationship between EPVS and lacunar infarction.OBJECTIVE:To investigate whether EPVS is associated with lacunar infarction on the basis of cerebral magnetic resonance(MR)examination,clinical symptoms and signs,and past medical history of patients.DESIGN,TIME AND SETTING:Case contrast analysis was performed at the Department of Neurology,Shanghai Ninth People's Hospital from January 2007 to January 2008.PARTICIPANTS:Sixty-eight patients with lacunar infarction were admired to the Department of Neurology of Shanghai Ninth People's Hospital,including 37 cases with first-ever infarction,and 31 with infarction recurrence.In addition,53 healthy people were selected as controls.METHODS:All participants underwent past medical history investigation,nervous system examination.and cranial MR.The subjects were assessed using the JMW rating scale to identify the EPVS grade.MAIN OUTCOME MEASURES:EPVS scores of patients and controls;risk factors for cerebral vascular disease in patients with first-ever or recurrence of lacunar infarction.RESULTS:The EPVS grade from lacunar infarction patients was significantly higher than of the control group(P<0.05).The EPVS grade in patients with recurring lacunar infarction was significantly higher than in patients with first-ever infarction(P<0.05).In addition,hypertension incidence in patients with recurring lacunar infarction was significantly higher than in patients wim first-ever infarction (P<0.05).CONCLUSION:Results indicate that EPVS is related to the incidence of lacunar infarction.Earlier screening of EPVS.and the evaluation of EPVS severity,is of great importance to control the risk factors for cerebral vascular disease and to prevent lacunar infarction.

  17. Ipsilateral Cerebral and Contralateral Cerebellar Hyperperfusion in Patients with Unilateral Cerebral Infarction; SPM Analysis

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    Hong, Sun Pyo; Yoon, Joon Kee; Choi, Bong Hoi; Joo, In Soo; Yoon, Seok Nam [Ajou University School of Medicine, Suwon (Korea, Republic of)

    2008-10-15

    Cortical reorganization has an important role in the recovery of stroke. We analyzed the compensatory cerebral and cerebellar perfusion change in patients with unilateral cerebral infarction using statistical parametric mapping (SPM). Fifty seven {sup 99m}Tc-Ethylene Cystein Diethylester (ECD) cerebral perfusion SPECT images of 57 patients (male/female=38/19, mean age=56{+-}17 years) with unilateral cerebral infarction were evaluated retrospectively. Patients were divided into subgroups according to the location (left, right) and the onset (acute, chronic) of infarction. Each subgroup was compared with normal controls (male/female=11/1, mean age =36{+-}10 years) in a voxel-by-voxel manner (two sample t-test, p<0.001) using SPM. All 4 subgroups showed hyperperfusion in the ipsilateral cerebral cortex, but not in the contralateral cerebral cortex. Chronic left and right infarction groups revealed hyperperfusion in the ipsilateral primary sensorimotor cortex, meanwhile, acute subgroups did not. Contralateral cerebellar hyperperfusion was also demonstrated in the chronic left infarction group. Using {sup 99m}Tc-ECD SPECT, we observed ipsilateral cerebral and contralateral cerebeller hyperperfusion in patients with cerebral infarction. However, whether these findings are related to the recovery of cerebral functions should be further evaluated.

  18. Watershed Cerebral Infarction in a Patient with Acute Renal Failure

    Directory of Open Access Journals (Sweden)

    Ruya Ozelsancak

    2016-02-01

    Full Text Available Acute renal failure can cause neurologic manifestations such as mood swings, impaired concentration, tremor, stupor, coma, asterixis, dysarthria. Those findings can also be a sign of cerebral infarct. Here, we report a case of watershed cerebral infarction in a 70-year-old female patient with acute renal failure secondary to contrast administration and use of angiotensin converting enzyme inhibitor. Patient was evaluated with magnetic resonance imaging because of dysarthria. Magnetic resonance imaging revealed milimmetric acute ischemic lesion in the frontal and parietal deep white matter region of both cerebral hemisphere which clearly demonstrated watershed cerebral infarction affecting internal border zone. Her renal function returned to normal levels on fifth day of admission (BUN 32 mg/dl, creatinine 1.36 mg/dl and she was discharged. Dysarthria continued for 20 days.

  19. Neuroimaging diagnosis for cerebral infarction An 8-year bibliometric analysis

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    Yan Du; Xiaoxia Yang; Hong Song; Bo Chen; Lin Li; Yue Pan; Qiong Wu; Jia Li

    2012-01-01

    OBJECTIVE:To identify global research trends in neuroimaging diagnosis for cerebral infarction using a bibliometric analysis of the Web of Science.DATA RETRIEVAL:We performed a bibliometric analysis of data retrieval for neuroimaging diagnosis for cerebral infarction containing the key words "CT,magnetic resonance imaging,MRI,transcranial Doppler,transvaginal color Doppler,digital subtraction angiography,and cerebral infarction" using the Web of Science.SELECTION CRITERIA:Inclusion criteria were:(a) peer-reviewed articles on neuroimaging diagnosis for cerebral infarction which were published and indexed in the Web of Science; (b) original research articles and reviews; and (c) publication between 2004-2011.Exclusion criteria were:(a) articles that required manual searching or telephone access; and (b) corrected papers or book chapters.MAIN OUTCOME MEASURES:(1)Annual publication output; (2) distribution according to country;(3) distribution according to institution; (4) top cited publications; (5) distribution according to journals; and (6) comparison of study results on neuroimaging diagnosis for cerebral infarction.RESULTS:Imaging has become the predominant method used in diagnosing cerebral infarction.The most frequently used clinical imaging methods were digital subtraction angiography,CT,MRI,and transcranial color Doppler examination.Digital subtraction angiography is used as the gold standard.However,it is a costly and time-consuming invasive diagnosis that requires some radiation exposure,and is poorly accepted by patients.As such,it is mostly adopted in interventional therapy in the clinic.CT is now accepted as a rapid,simple,and reliable non-invasive method for use in diagnosis of cerebrovascular disease and preoperative appraisal.Ultrasonic Doppler can be used to reflect the hardness of the vascular wall and the nature of the plaque more clearly than CT and MRI.CONCLUSION:At present,there is no unified standard of classification of cerebral infarction

  20. Diastolic myocardial dysfunction by tissue Doppler imaging predicts mortality in patients with cerebral infarction

    DEFF Research Database (Denmark)

    Olsen, Flemming J; Jørgensen, Peter G; Møgelvang, Rasmus;

    2015-01-01

    with cerebral infarction. Two hundred forty-four patients with cerebral infarction and subsequent echocardiographic examination in sinus rhythm were identified. Using TDI in three apical projections, longitudinal mitral annular velocities were obtained in six segments. Cox regression models, C...

  1. Pharmacological effects of Salvia miltiorrhiza (Danshen on cerebral infarction

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    Hsieh Ching-Liang

    2010-06-01

    Full Text Available Abstract Danshen, the dried root of Salvia miltiorrhiza, is a Chinese medicine used to promote blood flow and treat vascular disease. The present article reviews the pharmacological effects of Danshen on cerebral infarction and possible interactions between Danshen and Western drugs. Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggregation effects, which prevent cerebral infarction. Danshen may enhance endogenous anti-oxidative enzyme activities such as the expression of endothelial nitric oxide synthase and may scavenge oxygen free radicals. Prevention and treatment of cerebral infarction by Danshen involves multiple pathways, including anti-atherosclerosis, anti-hypertension, anti-platelet aggregation, anti-inflammatory and anti-oxidative effects.

  2. Involuntary masturbation and hemiballismus after bilateral anterior cerebral artery infarction.

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    Bejot, Yannick; Caillier, Marie; Osseby, Guy-Victor; Didi, Roy; Ben Salem, Douraied; Moreau, Thibault; Giroud, Maurice

    2008-02-01

    Ischemia of the areas supplied by the anterior cerebral artery is relatively uncommon. In addition, combined hemiballismus and masturbation have rarely been reported in patients with cerebrovascular disease. We describe herein a 62-year-old right-handed man simultaneously exhibiting right side hemiballismus and involuntary masturbation with the left hand after bilateral infarction of the anterior cerebral artery territory. Right side hemiballismus was related to the disruption of afferent fibers from the left frontal lobe to the left subthalamic nucleus. Involuntary masturbation using the left hand was exclusively linked to a callosal type of alien hand syndrome secondary to infarction of the right side of the anterior corpus callosum. After 2 weeks, these abnormal behaviours were completely extinguished. This report stresses the wide diversity of clinical manifestations observed after infarction of the anterior cerebral artery territory.

  3. Fulminant cerebral infarction of anterior and posterior cerebral circulation after ascending type of facial necrotizing fasciitis.

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    Lee, Jun Ho; Choi, Hui-Chul; Kim, Chulho; Sohn, Jong Hee; Kim, Heung Cheol

    2014-01-01

    Necrotizing fasciitis is a soft tissue infection that is characterized by extensive necrosis of the subcutaneous fat, neurovascular structures, and fascia. Cerebral infarction after facial necrotizing fasciitis has been rarely reported. A 61-year-old woman with diabetes was admitted with painful swelling of her right cheek. One day later, she was stuporous and quadriplegic. A computed tomographic scan of her face revealed right facial infection in the periorbital soft tissue, parotid, buccal muscle, and maxillary sinusitis. A computed tomographic scan of the brain revealed cerebral infarction in the right hemisphere, left frontal area, and both cerebellum. Four days later, she died from cerebral edema and septic shock. Involvement of the cerebral vasculature, such as the carotid or vertebral artery by necrotizing fasciitis, can cause cerebral infarction. Facial necrotizing fasciitis should be treated early with surgical treatment and the appropriate antibiotic therapy.

  4. Intrauterine extremity gangrene and cerebral infarction at term

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    Tanvig, M; Jørgensen, J S; Nybo, M;

    2011-01-01

    Intrauterine extremity gangrene in combination with cerebral infarction is a serious and rare event. We present a case with a healthy mother who gave birth to a child with this condition. At term, the mother presented at the antenatal clinic with decreased fetal movements. Cardiotocography (CTG......) showed signs of fetal distress and a caesarean section was performed. The left arm of the newborn was found gangrenous. Amputation of the arm was necessary and the child was subsequently treated with anticoagulant therapy due to thrombosis and cerebral infarction in the left hemisphere found by magnetic...

  5. The Clinical analyse of 206 patients of cerebral infarction (Abstract)

    Institute of Scientific and Technical Information of China (English)

    Mai Mai; Ti Yi Ming; Ghen Bo

    2000-01-01

    This thesis make a summary and analyse to 206 patients of cerebral infarction. The morbidity of the age from 51 to 70 is thehighist in 206 patients. It is 75.3 % a mong the patient that hypertension is original. The frequently-occurring cerebral in farction patient are 36.8 % and it is the highist. Because our hospital have purchased CT machinery, we can early diagnose cerebral infarction and do dissolving thrombus in early time, controlling blood pressure, clearing away free radical, dehydrating, di lating cerebral blood vessel, recovering treat early and so on. It reduced the appear ing of conplication and the death rate and viability by oneselfare improved obvious lv.

  6. Cerebral infarction in childhood bacterial meningitis

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    Snyder, R.D.; Stovring, J; Cushing, A H; Davis, L. E.; Hardy, T. L.

    1981-01-01

    Forty-nine children with complicated bacterial meningitis were studied. Thirteen had abnormalities on computed tomography compatible with the diagnosis of brain infarction; one had a brain biopsy with the histological appearance of infarction. Factors exist in childhood bacterial meningitis which are associated with the development of brain infraction.

  7. Cerebral infarction and cerebral salt wasting syndrome in a patient with tuberculous meningoencephalitis.

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    Loo, K L; Ramachandran, R; Abdullah, B J; Chow, S K; Goh, E M L; Yeap, S S

    2003-09-01

    A 38-year old female with underlying systemic lupus erythematosus was admitted with tuberculous meningoencephalitis. After an initial good response to anti-tuberculous treatment, she developed cerebral infarction and profound hyponatremia. This was due to cerebral salt wasting syndrome, which has only previously been described in 2 cases. The difficulties in diagnosis and management of this case are discussed.

  8. Cerebral salt-wasting syndrome due to hemorrhagic brain infarction: a case report

    OpenAIRE

    Tanaka, Tomotaka; Uno, Hisakazu; Miyashita, Kotaro; Nagatsuka, Kazuyuki

    2014-01-01

    Introduction Cerebral salt-wasting syndrome is a condition featuring hyponatremia and dehydration caused by head injury, operation on the brain, subarachnoid hemorrhage, brain tumor and so on. However, there are a few reports of cerebral salt-wasting syndrome caused by cerebral infarction. We describe a patient with cerebral infarction who developed cerebral salt-wasting syndrome in the course of hemorrhagic transformation. Case presentation A 79-year-old Japanese woman with hypertension and ...

  9. SPECT analysis of recent cerebral infarction

    DEFF Research Database (Denmark)

    Raynaud, C; Rancurel, G; Tzourio, N

    1989-01-01

    already differentiated in the subacute period. The central area presented a short phase of luxury perfusion and a longer phase of IMP hyperfixation. The peripheral area showed both a slight regional cerebral blood flow decrease and an early IMP uptake decrease similar to those previously found...

  10. A large left atrial myxoma causing multiple cerebral infarcts.

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    Kebede, Saba; Edmunds, Eiry; Raybould, Adrian

    2013-11-27

    A 52-year-old man presented with a history of sudden onset diplopia. On neurological examination, the only abnormality was a right-sided oculomotor (third nerve) palsy. A brain CT was performed and reported as showing no abnormality. He was discharged to be investigated as an outpatient. He presented 1 month later with a new expressive dysphasia and confusional state. MRI was performed which revealed multiple cerebral infarcts. He was discharged on secondary stroke prevention medication. Six months elapsed, before a transthoracic echocardiogram was performed. This showed a large left atrial myxoma. The patient underwent an emergency resection and made a good postoperative recovery. This case report showed the importance of considering a cardiogenic source of emboli in patients who present with cerebral infarcts. Performing echocardiography early will help to detect treatable conditions such as atrial myxoma, and prevent further complications.

  11. EFFECT OF ACUPUNCTURE ON EXPERIMENTAL CEREBRAL INFARCTION IN RATS

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    YUNG Qing; MA Ruiling; JIN Rui

    2002-01-01

    Objectives: To explore the effect of acupuncture on cerebral infarction in rats and to try providing some experimental parameters for clinical practice. Methods: 27 healthy Wistar rats were randomly divided into pseudo-operation (n = 10), model (n = 8) and acupuncture (n = 9) groups. Neuro-functional defect scoring, apoptosis of single brain slice and the number of bcl-2 immuno-reaction (IR)-positive neurons in CA1 area of the hippocampus were used as the indexes to investigate the possible mechanisms of acupuncture of "Nie San Zhen" (needling three acupoints in the temporal region) and "Si Shen Zhen" (needling four acupoints in the occiput region) in treating rats with cerebral infarction. Results: There existed significant differences between acupuncture group and model group in improving neurologic functional activities, inhibiting apoptosis of the brain cells and increasing bcl-2 IR-positive neurons in the hippocampal CA1 area (P < 0.01 ). Conclusion: Acupuncture therapy can improve cerebral infarction in the rat by suppressing apoptosis and up-regulation of the bcl-2 IR-positive neuron expression.

  12. EFFECT OF ACUPUNCTURE ON EXPERIMENTAL CEREBRAL INFARCTION IN RATS

    Institute of Scientific and Technical Information of China (English)

    袁青; 马瑞玲; 等

    2002-01-01

    Objectives:To explore the effect of acupuncture on cerebral infarction in rats and to try providing some experimental parameters for clinical practice.Methods:27 healthy Wistar rats were randomly divided into pseudo-operation (n=10),model (n=8) and acupuncture (n=9) groups.Neuro-functional defect scoring,apoptosis of single brain slice and the number of bcl-2 immuno-reaction (IR)-positive neurons in CA1 area of the hippocampus were used as the indexes to investigate the possible mechanisms of acupuncture of “Nie San Zhen”(needing three acupoints in the temporal region) and “Si Shen Zhen” (needling four acupoints in the occiput region) in treating rats with cerebral infarction.Results:There existed significant differences between acupuncture group and model group in improving neurologic functional activities,inhibiting apoptosis of the brain cells and increasing bcl-2 IR-positive neurons in the hippocampal CA1 area(P<0.01).Conclusion:Acupuncture therapy can improve cerebral infarction in the rat by suppressing apoptosis and up-regulation of the bcl-2 IR-positive neuron expression.

  13. Evaluation of multislice computed tomographic perfusion imaging and computed tomographic angiography on traumatic cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    XU Fang-hong; CHEN Wei-jian; YANG Yun-jun; DUAN Yu-xia; FU Feng-li

    2008-01-01

    Objective: To evaluate the application value of multislice computed tomographic perfusion imaging (MSCTPI) and multislice computed tomographic angiography (MSCTA) on traumatic cerebral infarction. Methods: MSCTA was performed on 10 patients who were initiailly diagnosed as traumatic cerebral infarction by normal conventional computed tomography (NCCT), among whom, 3 patients were examined by MSCTPI simultaneously. Reconstructed images of the intracranial artery were made with techniques of maximum intensity projection (MIP) and volume rendering (VR) from MSCTA scanning data. Then the graph of function of four parameters, regional cerebral blood flow (Rcbf), regional cerebral blood volume (Rcbv), mean transit time (MTT), and time to peak (TTP), acquired by the perfusing analysis software was obtained. Results: Among the 10 patients with traumatic cerebral infarction, 6 showed complex type on NCCT, which depicted abnormality on MSCTA, and 4 showed simple type on NCCT, which had negative results on MSCTA. Among the 4 patients with abnormal great vessels, 2 suffered from steno sis or occlusion of the middle cerebral artery, 1 from spasm of the anterior cerebral artery, and 1 from spasm of the vertebral-basal artery. The image of MSCTPI of 1 patient with massive cerebral infarction on the right cerebral hemisphere confirmed by CT was smaller than those of the other patients, which showed occlusion of the ipsilateral middle cerebral artery on MSCTA. Among the 6 patients whose MSCTA showed no abnormality, 4 showed simple infarction and 2 showed complex infarction. The infarction focus of 5 patients occurred in the basal ganglia and 1 in the splenium of corpus callosum. Among the 2 cases of small cerebral infarction volume on NCCT, one was normal, the other showed hypoperfusion on MSCTPI and was normal on MSCTA. Conclusion: The combination of MSCTPI and MSCTA is very useful for evaluating the change of intracranial artery in ischemic regions and assessing the cerebral

  14. Expression of Sema4D in patients with cerebral infarction and its clinical significance

    Institute of Scientific and Technical Information of China (English)

    朱琳

    2012-01-01

    Objective To explore the expression and clinical significance of Semaphorin4D (Sema4D) mRNA in peripheral blood lymphocyte,Sema4D on platelet surface, soluble Sema4D (sSema4D) in plasma in patients with cerebral infarction. Methods Taking 299 patients with cerebral infarction

  15. The relationship between lipoprotein lipase-447C/G genepolymorphism and cerebral infarction in the elderly

    Institute of Scientific and Technical Information of China (English)

    胡晓雁

    2013-01-01

    Objective To explore the relationship between the lipoprotein lipase(LPL)-447C/G gene polymorphism and cerebral infarction in the elderly. Methods This was a case-control study,which enrolled 206 cases with cerebral infarction in the elderly and 203 elderly

  16. Acute-phase proteins in stroke: influences of its cause (cerebral hemorrhage or infarction), of the cerebral site of infarction, and of the sex of patients.

    Science.gov (United States)

    Ionescu, D A; Haţegan, D; Jipescu, I; Steinbruch, L; Scu, M G

    1991-01-01

    In most of the 129 patients with a recent stroke by cerebral hemorrhage or infarction a note-worthy acute-phase response was found, as demonstrated by important quantitative alterations of blood levels of several acute-phase proteins (APP). These alterations were different in patients with cerebral hemorrhage as compared to those with cerebral infarction. The alterations due to cerebral infarction were not different according to the site of the infarction in brain, i.e. in the brain territories irrigated by the carotid artery system or by the basilar artery system. The APP alterations do not depend on the sex of patients or on the time elapsed from stroke-onset to blood collection.

  17. Cerebral infarction after mild head trauma in children.

    Science.gov (United States)

    Yang, Feng-Hua; Wang, Hua; Zhang, Jun-Mei; Liang, Hong-Yuan

    2013-09-01

    We conducted this retrospective, case record review to determine the risk factors and clinical features associated with cerebral infarction after mild head trauma in children. The median age of the cohort was 2.18 years (range, 6 mo-8 y). Most (26/29) of the patients developed the neurological symptoms and signs within 72 hours after trauma, 51.7% within 30 minutes. The first symptoms included hemiparesis (20), facial paresis (7), and convulsion (7). 86.21% of the lesions lay in basal ganglia region. Pre-existing basal ganglia calcification was identified in 13 as a risk factor.

  18. A case of Netherton's syndrome with cerebral infarction.

    Science.gov (United States)

    Calikoğlu, E; Anadolu, R; Sanli, H; Erdem, C

    2001-01-01

    Netherton's syndrome, a rare congenital disease of childhood, is characterized by variable cutaneous erythematous eruptions with different manifestations. A five-year-old boy, who presented with ichthyosis linearis circumflexa, atopic manifestations and pili torti, had spastic hemiparesia due to cerebral infarction. Netherton's syndrome can easily be misdiagnosed as Leiner's disease, generalized psoriasis or nonbullous congenital ichthyosiform erythroderma, especially in the neonatal period, because of its nonspecific clinical and histological features. Pediatricians should consider this syndrome in the differential diagnosis of the generalized erythematous skin disorders of childhood associated with various abnormalities.

  19. A new non-human primate model of photochemically induced cerebral infarction.

    Directory of Open Access Journals (Sweden)

    Satoshi Ikeda

    Full Text Available BACKGROUND AND PURPOSE: Rat models of photochemically induced cerebral infarction have been readily studied, but to date there are no reports of transcranial photochemically induced infarctions in the marmoset. In this report, we used this non-human primate as a model of cerebral thrombosis and observed the recovery process. METHODS: Five common marmosets were used. Cerebral ischemia was produced via intravascular thrombosis induced by an intravenous injection of Rose Bengal and irradiation with green light. After inducing cerebral infarction, we observed the behavior of marmosets via a continuous video recording. We evaluated maximum speed, mean speed, and distance traveled in 1 min. In addition, we evaluated scores for feeding behavior, upper limb grip, and lower limb grip. We confirmed the infarct area after cerebral infarction using 2,3,5-triphenyltetrazolium chloride staining in a separate marmoset. RESULTS: We found functional decreases 2 days after creating the cerebral infarction in all measurements. Total distance traveled, average speed, upper limb score, and feeding behavior score did not recover to pre-infarction levels within 28 days. Maximum speed in 1 min and lower limb score recovered 28 days after infarction as compared to pre-infarction levels. We confirmed the infarct area of 11.4 mm × 6.8 mm as stained with 2,3,5-triphenyltetrazolium chloride. CONCLUSION: We were able to create a primate photothrombosis-induced cerebral infarction model using marmosets and observe functional recovery. We suggest that this is a useful model for basic research of cerebral infarction.

  20. Patent Foramen Ovale in Patients with Cerebral Infarction: A Transesophageal Echocradigraphy Study

    Science.gov (United States)

    Petty, George W.; Khandheria, Bijoy K.; Chu, Chu-Pin; Sicks, JoRean D.; Whisnant, Jack P.

    1997-01-01

    Patent foramen ovale was detected in 37 patients (32%). Mean age was similar in those with (60 years) and those without (64 years) PFO. Patent foramen ovale was more frequent among men (39%) than women (20%, P=.03). Patients with PFO had a lower frequency of atrial fibrillation, diabetes me!litus, hypertension, and peripheral vascular disease compared with those without PFO. There was no difference in frequency of the following characteristics in patients with PFO compared with those without PFO: pulmonary embolus, chronic obstructive pulmonary disease, pulmonary hypertension, peripheral embolism, prior cerebral infarction, nosocomial cerebral infarction, Valsalva maneuver at the time of cerebral infarction, recent surgery, or hemorrhagic transformation of cerebral infarction. Patent foramen ovale was found in 22 (40%) of 55 patients with infarcts of uncertain cause and in 15 (25%) of 61 with infarcts of known cause (cardioembolic, 21%; large vessel atherostenosis, 25%; lacune, 40%) (P=.08). When the analysis was restricted to patients who underwent Valsalva maneuver, PFO with right to left or bidirectional shunt was found in 19 (50%) of 38 patients with infarcts of uncertain cause and in 6 (20%) of 30 with infarcts of known cause (P=.Ol). Conclusion: Although PFO was over-represented in patients with infarcts of uncertain cause in our and other studies, it has a high frequency among patients with cerebral infarction of all types. The relation between PFO and stroke requires further study.

  1. Aquaporin-4 gene silencing protects injured neurons after early cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Zhan-ping He; Hong Lu

    2015-01-01

    Aquaporin-4 regulates water molecule channels and is important in tissue regulation and water transportation in the brain. Upregulation of aquaporin-4 expression is closely related to cel-lular edema after early cerebral infarction. Cellular edema and aquaporin-4 expression can be determined by measuring cerebral infarct area and apparent diffusion coefficient using diffu-sion-weighted imaging (DWI). We examined the effects of silencing aquaporin-4 on cerebral infarction. Rat models of cerebral infarction were established by occlusion of the right middle cerebral artery and siRNA-aquaporin-4 was immediately injectedvia the right basal ganglia. In control animals, the area of high signal intensity and relative apparent diffusion coefifcient value on T2-weighted imaging (T2WI) and DWI gradually increased within 0.5–6 hours after cerebral infarction. After aquaporin-4 gene silencing, the area of high signal intensity on T2WI and DWI reduced, relative apparent diffusion coefifcient value was increased, and cellular edema was ob-viously alleviated. At 6 hours after cerebral infarction, the apparent diffusion coefifcient value was similar between treatment and model groups, but angioedema was still obvious in the treat-ment group. These results indicate that aquaporin-4 gene silencing can effectively relieve cellular edema after early cerebral infarction; and when conducted accurately and on time, the diffusion coefifcient value and the area of high signal intensity on T2WI and DWI can relfect therapeutic effects of aquaporin-4 gene silencing on cellular edema.

  2. Neonatal cerebral infarction; Symptoms, CT findings and prognosis

    Energy Technology Data Exchange (ETDEWEB)

    Fujimoto, Shinji; Togari, Hajime; Sobajima, Hisanori; Suzuki, Shigesumi; Wada, Yoshiro (Nagoya City Univ. (Japan). Faculty of Medicine); Yokochi, Kenji; Nishimura, Yutaka; Inukai, Kazuhisa; Futamura, Masahide

    1992-01-01

    In a retrospective multi-center study, we investigated eighteen infants with unilateral cerebral infarctions confirmed by computed tomography (CT) scans. The initial symptoms were observed in all the patients between 0 and 3 days of age. Convulsions or apneic attacks were the initial symptoms in all but one. Only 4 patients had complicated obstetric histories and none showed polycythemia or electrolyte abnormalities. All of the initial CT scans revealed unilaterally localized hypodense areas. In 10, the initial CT scans were performed within 24 hours after the clinical onset. In 16, the lesions were within the territory of the middle cerebral artery, 9 of which also involved the cortico-spinal tract (CST). In the remaining 2 patients, the lesions were located whithin the territory of the posterior cerebral artery. None of the 9 patients without CST involvement developed hemiplegia, whereas 5 (56%) of the 9 with CST involvement had hemiplegia, which is a fairly low incidence compared with that in adult cases. This difference was thought to be related to neonatal brain plasticity. (author).

  3. PROLIFERATION AND DIFFERENTIATION OF NEURAL STEM CELLS IN ADULT RATS AFTER CEREBRAL INFARCTION

    Institute of Scientific and Technical Information of China (English)

    Bo Zhang; Ren-zhi Wang; Yong Yao; Zhi-hai Liu; Zhi-gang Lian; Yu-jie Zou; Yu-kui Wei

    2004-01-01

    Objective To investigate proliferation and differentiation of neural stem cells in adult rats after cerebral infarction.Methods Models of cerebral infarction in rats were made and the time-course expression of bromodeoxyuridine (BrdU), Musashil, glial fibrillary acidic protein (GFAP), and neuronal nuclear antigen (NeuN) were determined by immunohistochemistry and immunofluorescence staining. BrdU and Musashil were used to mark dividing neural stem cells. GFAP and NeuN were used to mark differentiating neural stem cells.Results Compared with controls, the number of BrdU-labeled and BrdU-labeled with Musashil-positive cells increased strikingly 1 day after cerebral infarction; approximately 6 fold with a peak 7 days later; markedly decreased 14 days later, but was still elevated compared with that of controls; decling to the control level 28 days later. The number of BrdU-labeled with GFAP-positive cells nearly remained unchanged in the hippocampus after cerebral infarction. The number of BrdU-labeled with NeuN-positive cells increased strikingly 14 days after cerebral infarction, reached maximum peak in the hippocampus 28 days after cerebral infarction in rats.Conclusion Cerebral infarction stimulate proliferation of inherent neural stem cells and most proliferated neural stem cells differentiate into neurons.

  4. Study on the relationship between serum interleukins, platelet activation indexes and cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Bo Wu

    2015-01-01

    Objective:To study and investigate the relationship between serum interleukins, platelet activation indexes and cerebral infarction.Methods:58 patients with cerebral infarction in our hospital from March 2013 to September 2014 were selected as observation group; meanwhile, 58 healthy persons at the same period were selected as control group, then the serum interleukins and platelet activation indexes of two groups were detected and compared, then the detection results of observation group with different stages and severity of cerebral infarction were compared too, and the relationship between those blood detection indexes and cerebral infarction were analyzed by the Logistic analysis.Results:The serum interleukins and platelet activation indexes of observation group were obviously higher than those of control group, and the detection levels of observation group with cerebral infarction at early and severe stage were obviously higher than those of patients at other stages and light, moderate, and those blood indexes all had close relationship to the cerebral infarction by the Logistic analysis,P<0.05. Conclusion:The serum interleukins and platelet activation indexes all have close relationship to cerebral infarction, and they can be as the important monitoring indexes of the disease.

  5. Bilateral olfactory ensheathing cell transplantation promotes neurological function in a rat model of cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Zhihua Yang; Wenli Sheng; Huiyong Shen; Qinghua Hou; Rui Li; Jinsheng Zeng; Ruxun Huang

    2011-01-01

    In the present study, olfactory ensheathing cells were transplanted into the cortices of infarcted (infarct transplantation group), normal (normal transplantation group), and bilateral hemispheres (bilateral transplantation group). Olfactory ensheathing cells migrated to the infarct focus. The number of growth associated protein 43-positive cells and nerve fibers was slightly increased in the infarct area. These changes were more evident in the bilateral cortical transplantation group. Results demonstrated that transplanted olfactory ensheathing cells can migrate in rats with cerebral infarction. The olfactory ensheathing cells on the normal side can also promote neurological function. Bilateral cortical transplantation exhibited superior effects over unilateral transplantation.

  6. Coffee component 3-caffeoylquinic acid increases antioxidant capacity but not polyphenol content in experimental cerebral infarction.

    Science.gov (United States)

    Ruiz-Crespo, Silvia; Trejo-Gabriel-Galan, Jose M; Cavia-Saiz, Monica; Muñiz, Pilar

    2012-05-01

    Although coffee has antioxidant capacity, it is not known which of its bioactive compounds is responsible for it, nor has it been analyzed in experimental cerebral infarction. We studied the effect one of its compounds, 3-caffeoylquinic acid (3-CQA), at doses of 4, 25 and 100 μg on plasma antioxidant capacity and plasma polyphenol content, measuring the differences before and after inducing a cerebral infarction in an experimental rat model. We compared them with 3-caffeoylquinic-free controls. The increase in total antioxidant capacity was only higher than in controls in 3-CQA treated animals with the highest dose. This increase in antioxidant capacity was not due to an increase in polyphenols. No differences between the experimental and control group were found regarding polyphenol content and cerebral infarction volume. In conclusion, this increase in antioxidant capacity in the group that received the highest dose of 3-CQA was not able to reduce experimental cerebral infarction.

  7. Cerebral hemodynamics and metabolism in patients with moyamoya disease not demonstrating either cerebral infarct or hemorrhage on MRI

    Energy Technology Data Exchange (ETDEWEB)

    Kuwabara, Yasuo; Ichiya, Yuichi; Sasaki, Masayuki; Akashi, Yuko; Yoshida, Tsuyoshi; Fukumura, Toshimitsu; Masuda, Kouji; Matsushima, Toshio; Fukui, Masashi [Kyushu Univ., Fukuoka (Japan). Faculty of Medicine

    1995-12-01

    We evaluated the cerebral hemodynamics and metabolism in moyamoya patients who did not demonstrate either cerebral infarct or hemorrhage on MRI. The subjects consisted of 5 patients with moyamoya disease (4 females and one male, aged from 15 to 40 ears). The CBF, OEF and CMRO{sub 2} of the moyamoya patients did not differ from those of the normal control subjects. The CBV did increase significantly in the cerebral cortices and striatum, but not in the cerebellum. The TT was also significantly prolonged in the frontal and parietal regions. The cerebrovascular CO{sub 2} response was markedly impaired in the frontal, temporal and parietal cortices. However, it was relatively preserved in the occipital cortex, thalamus and cerebellum. Thus, the cerebral hemodynamic reserve capacity decreased even in the moyamoya patients not demonstrating either cerebral infarct or hemorrhage on MRI, and it should be considered in the management of these patients. (author).

  8. Diffusion tensor imaging detects Wallerian degeneration of the corticospinal tract early after cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Ruiman Xie; Min Fang; Linjiang Zhou; Shanghua Fan; Jianying Liu; Hongbo Quan; Man Luo; Dongying Qiu

    2012-01-01

    To investigate the feasibility and time window of early detection of Wallerian degeneration in the corticospinal tract after middle cerebral artery infarction, 23 patients were assessed using magnetic resonance diffusion tensor imaging at 3.0T within 14 days after the infarction. The fractional anisotropy values of the affected corticospinal tract began to decrease at 3 days after onset and decreased in all cases at 7 days. The diffusion coefficient remained unchanged. Experimental findings indicate that diffusion tensor imaging can detect the changes associated with Wallerian degeneration of the corticospinal tract as early as 3 days after cerebral infarction.

  9. Predicting hemorrhagic transformation by microvascular permeability using perfusion CT acute cerebral infarction in elderly patients

    Institute of Scientific and Technical Information of China (English)

    田超

    2014-01-01

    Objective To study the possibility of microvascular permeability(PS)value derived from perfusion CT(PCT)in predicting hemorrhagic transformation(HT)in acute cerebral infarction in elderly patients.Methods 52consecutive patients with middle cerebral artery acute ischemic stroke who received thrombolytic therapy were divided into HT group and control group,and patients in

  10. Correlation of Cerebral Blood Flow with Memory in Patients with Cerebral Infarction%脑梗死病人脑血流与记忆的相关研究

    Institute of Scientific and Technical Information of China (English)

    汪洪; 侯靖边; 梁燕; 刘枢晓; 王文富

    2001-01-01

    Objective:To investigate the relation of cerebral blood flow(CBF) and memory in patients with cerebral infarction. Methods:The cerebral blood flow of 30 patients with cerebral infarction and 20 healthy controls was measured. The WMS was used for memory function assessment. Results: CBF and memory performance in patients group were lower than those of controls. There was a statistically significant correlation between CBF and memory performances. Conclusion: The decreasing of CBF was an important causal factor to the memory dysfunction in cerebral infarction patients.

  11. Decompressive craniectomy in massive cerebral infarction Craniectomia descompressiva no infarto cerebral extenso

    Directory of Open Access Journals (Sweden)

    João Paulo Mattos

    2010-06-01

    Full Text Available Twenty one patients were submitted to decompressive craniectomy for massive cerebral infarct. Ten patients (47.6% presented a good outcome at the 6 months evaluation, eight had a poor outcome (38% and three died (14.2%. There was no outcome statistical difference between surgery before and after 24 hours of ictus, dominant and non-dominant stroke groups. Patients older than 60 years and those who had a Glasgow Coma Scale (GCS8 at pre-surgical exam and decompressive craniectomy before signs of brain herniation represent the main factors related to a better outcome. Dominant hemispheric infarction does not represent exclusion criteria.Vinte e um pacientes foram submetidos a craniectomia descompressiva para o tratamento de infarto cerebral extenso. Dez pacientes (47,6% apresentaram boa evolução em avaliação após 6 meses, 8 apresentaram evolução desfavorável (38% e 3 faleceram (14,2%. Durante o seguimento, não se evidenciou diferença estatística na evolução entre pacientes operados antes e após 24 horas do ictus, nem entre lesões envolvendo o hemisfério dominante versus não dominante. Pacientes com mais de 60 anos e aqueles com Escala de Coma de Glasgow (ECG8 no exame pré-operatório e craniectomia descompressiva antes de sinais de herniação cerebral representam os principais fatores relacionados a uma melhor evolução clínica. Infarto hemisférico envolvendo o hemisfério dominante não representa um critério de exclusão.

  12. Renal Subcapsular Hematoma after Intravenous Thrombolysis in a Patient with Acute Cerebral Infarction.

    Science.gov (United States)

    La, Yun Kyung; Kim, Ji Hwa; Lee, Kyung-Yul

    2016-09-01

    A 74-year-old female with acute cerebral infarction was treated with intravenous recombinant tissue plasminogen activator. Subsequent percutaneous transfemoral angiography and mechanical thrombectomy were performed due to a right middle cerebral artery occlusion, which was successfully recanalized. Two days after treatment, the patient complained of vague right abdominal pain and a laboratory test showed anemia. Abdominal computed tomography showed a right renal subcapsular hematoma. After conservative management, the patient was discharged without complications. We report a rare complication after intravenous thrombolysis in a patient with acute cerebral infarction.

  13. Acute Cerebral Infarction after FK 506 Administration in a Kidney Transplantation Recipient: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Ji Kyung; Byun, Woo Mok; Kim, Jae Woon [Yeungnam University College of Medicine, Daegu (Korea, Republic of)

    2011-02-15

    FK506 is widely used as a potent immunosuppressive agent following organ transplantation. However, the use of FK506 is associated with a wide spectrum of neurotoxicity. FK506-induced cerebral infarctions have rarely been reported. We report here on a case of the acute cerebral infarction caused by vasospasm after FK506 administration in a kidney transplantation recipient. There were areas with increased signal intensity on the diffusion-weighted image. The areas showing increased signal intensity on the diffusion- and T2-weighted images demonstrated decreased signal intensity on the apparent diffusion coefficient mapping. MR angiography showed diffuse stenosis in both the anterior and middle cerebral arteries

  14. Progressive encephalopathy with cerebral oedema and infarctions associated with valproate and diazepam overdose.

    Science.gov (United States)

    Rupasinghe, J; Jasinarachchi, M

    2011-05-01

    Valproic Acid (VPA) in overdose is known to cause encephalopathy with or without cerebral odema, hyperammonaemia, hepatotoxicity, bone marrow suppression and non gap acidosis. Most of these conditions are reversible. We report a 45-year-old man who suffered permanent disability from the non reversible effects of cerebral odema and infarctions associated with Valproate overdose which would have been aggravated by Diazepam. This patient's presentation emphasizes the role of early detection and therapy of cerebral odema in Valproate and Diazepam overdose.

  15. OCULO-ACUPUNCTURE TREATMENT OF CEREBRAL INFARCTION INDUCED HEMIPLEGIA

    Institute of Scientific and Technical Information of China (English)

    FU Wenbin; FAN Li; MENG Changrong; LI Weixiong; MI Jianping

    2002-01-01

    Objective: To observe the therapeutic effect of oculo-acupuncture therapy in the treatment of cerebral infarction induced hemiplegia. Methods: 58 cases of stroke patients were randomly divided into treatment group (n =30) and control group (n = 28). In treatment group, on the basis of medication plus rehabilitation treatment, patients voluntarily accepted oculo-acupuncture therapy (acupuncture of Upper-Jiao Area and Lower-Jiao Area). In control group, patients only accepted medication and rehabilitation treatment. The therapeutic effect was evaluated with Brunstrom's 6-stages Assessing Method. Results: After 24 sessions of treatment, the ratios of the diseased limbs reaching stage Ⅵ and more in functional activity in the patients of treatment group increased from 16.7% (upper-limb) and 20.0% (lower-limb) before treatment to 70.0% and 90.0% respectively; while in control group, those ratios of the upper and lower limbs increased from 10.7% and 28.6% before treatment to 39.2% and 60.7% separately. There was a significant difference between two groups in the therapeutic effect (P < 0.05). Conclusion: Oculo-acupuncture plus medication is superior to simple medication treatment in improving functional activity of the hemiplegic limbs.

  16. Association of apolipoprotein E 4 polymorphism with cerebral infarction in Chinese Han population

    Institute of Scientific and Technical Information of China (English)

    Zhu-qing JIN; Wei-feng JI; Jian-gang ZHANG; Yong-sheng FAN; Jing DING; Mei CHEN; Wei FAN; Guang-ji ZHANG; Bin-hui ZHANG; Suo-jing YU; Yong-sheng ZHANG

    2004-01-01

    AIM: To study the association between APOE polymorphisms and cerebral infarction through a case-control study among the Chinese Han population. METHODS: First-ever cerebral infarction patients (n=226) whose ages ranged from 40 to 60 years old were recruited from Department of Neurology, Zhongshan Hospital, Shanghai, and Zhejiang Chinese Traditional Medicine Hospital, Zhejiang, China. Unrelated healthy controls (n=201) were selected from the general population in the same area with similar age and sex distribution. APOE was amplified by one-stage PCR using the forward primer: 5'-GGC ACG GCT GTC CAA GGA GCT-3' and reverse primer: 5'-GAT GGC GCT GAG GCC GCG CT-3'. The PCR product was digested directly with 5 U of CfoI and separated by a 20 % polyacrylamide (acrylamide: bis-acrylamide=29:1) nondenaturing gel. RESULTS: Both cerebral infarction patient and control groups were in Hardy-Weinberg equilibrium. The allele frequency ofAPOE*2, APOE*3, and APOE*4 was 4.6 %,81.9 %, and 13.5 % respectively in the patients with cerebral infarction; 5.7 %, 87.3 %, and 7.0 % respectively in the healthy control group. Compared with APOE3/3 subjects, APOE4/4 carriers had a 2.1-fold risk of cerebral infarction (odds ratio 2.1, 95 % confidence limits 1.3 to 3.4). The allele frequency of APOE*4 in the cerebral infarction patient group was significantly higher than that in the control group (13.5 % vs 7.0 %; P=0.002).CONCLUSION: APOE 4 is a risk factor for cerebral infarction among the Chinese Han population.

  17. 脑梗死合并糖尿病对患者神经功能的影响%Impact of cerebral infarction complicated by diabetes on neurological function

    Institute of Scientific and Technical Information of China (English)

    江先娣; 冼明健

    2002-01-01

    Background:Diabetes is a factor resulting cerebral infarction.Neurological injury in patients suffered from cerebral infarction complicated with diabetes is more common and severe than that in patients with cerebral infarction alone.From December 1990 to Octomber 2001,144 patients with CT proved cerebral infarction were surveyed including 28 patients suffered from cerebral infarction complicated with diabetes and 116 patients with cerebral infarction alone.Here is the report.

  18. DI-3-butylphthalide-enhanced hematopoietic stem cell transplantation and endogenous stem cell mobilization for the treatment of cerebral infarcts

    Institute of Scientific and Technical Information of China (English)

    Baoquan Lu; Xiaoming Shang; Yongqiu Li; Hongying Ma; Chunqin Liu; Jianmin Li; Yingqi Zhang; Shaoxin Yao

    2011-01-01

    Exogenous stem cell transplantation and endogenous stem cell mobilization are both effective for the treatment of acute cerebral infarction. The compound dl-3-butylphthalide is known to improve microcirculation and help brain cells at the infarct loci. This experiment aimed to investigate the effects of dl-3-butylphthalide intervention based on the transplantation of hematopoietic stem cells and mobilization of endogenous stem cells in a rat model of cerebral infarction, following middle cerebral artery occlusion. Results showed that neurological function was greatly improved and infarct volume was reduced in rats with cerebral infarction. Data also showed that dl-3-butylphthalide can promote hematopoietic stem cells to transform into vascular endothelial cells and neuronal-like cells, and also enhance the therapeutic effect on cerebral infarction by hematopoietic stem cell transplantation and endogenous stem cell mobilization.

  19. Plasma thrombomodulin changes in acute cerebral infarction or hypertension patients An observation for verification

    Institute of Scientific and Technical Information of China (English)

    Pu Feng; Hui Zhang; Bingyi Yang; Yonggang Zheng; Jinhui Xie; Ying Wang; Jinchuan Li

    2008-01-01

    BACKGROUND: Thrombomodulin concentration greatly increases in plasma when vascular endothelial cells are injured, and it is one of the specific molecular markers for endothelial injury.OBJECTIVE: To analyze the plasma levels of thrombomodulin after cerebral infarction or hypertension, and to compare levels with those from healthy control subjects.DESIGN: A case-controlled observation. SETTING: Yuquan Hospital of Tsinghua University.PARTICIPANTS: Patients with hypertension (n = 37) and acute cerebral infarction (n = 26) were selected from the outpatient and inpatient Department of Neurology, Yuquan Hospital of Tsinghua University from February 2003 to February 2006. The cerebral infarction group consisted of 24 males and 2 females, 36–77 years of age, with a mean age of 62 years. All patients fulfilled the diagnosis criteria for cerebral infarction, according to the diagnostic standards revised by the Second National Academic Meeting for Cerebrovascular Disease, and were confirmed by CT or MRI. The hypertension group consisted of 27 males and 10 females, 36–77 years of age, with a mean age of 56 years. These patients fulfilled the diagnostic criteria for hypertension set by WHO. In addition, 43 healthy physical examinees were selected as the control group, consisting of 23 males and 20 females, 35–67 years of age.Informed consent was obtained from all participants.METHODS: In the cerebral infarction group, thrombomodulin plasma levels were determined by enzyme-linked immunoabsorbent assay at days 1, 3, 7, and 14 after attack. Thrombomodulin plasma levels were determined only once in the hypertension group and the control group. The results from the cerebral infarction group were compared with those from the hypertension group and the control group. MAIN OUTCOME MEASURES: Level of thrombomodulin in plasma.RESULTS: All 63 patients and 43 healthy volunteers were included in the final analysis of results. ① At 7 days after the attack, the plasma levels of

  20. The changes and significance of serum inflammatory factors and hemodynamics in patients with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Xiao-Wei Lu

    2016-01-01

    Objective:To investigate the changes of serum inflammatory factors and hemodynamics in patients with acute cerebral infarction and its clinical significance.Methods: A total of 55 cases of acute cerebral infarction (ACI) patients as observation group, and cases of healthy physical examination were selected as the observation group, and 55 healthy persons as control group. ELISA method was used to detect inflammatory cytokines interleukin-6 (IL-6), interleukin-8 (IL-8), C-reactive protein (CRP) and tumor necrosis factor (TNF-α) level, WA-880 heart and brain integrated digital hemodynamic monitor to detect bilateral carotid artery blood flow velocity, blood flow and peripheral resistance.Results:The serum levels of IL-8, CRP, IL-6 and TNF-α were higher in the observation group than in the control group, the difference was statistically significant (P<0.05). The blood flow velocity and blood flow velocity in the observation group were significantly lower than those in the control group. The difference was statistically significant (IL-8). With the increase of infarct size, serum IL-6, CRP,P<0.05 and TNF-α increased significantly (P<0.05).Conclusions:The changes of serum inflammatory factors and hemodynamic indexes can be used to judge the early cerebral infarction and the size of the infarct size of the index, the clinical dynamic monitoring of its changes in patients with acute cerebral infarction and the severity of the prognosis and the prognosis of the important significance of the judgment.

  1. Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia.

    Science.gov (United States)

    Kaplan, B; Brint, S; Tanabe, J; Jacewicz, M; Wang, X J; Pulsinelli, W

    1991-08-01

    We investigated the temporal threshold for focal cerebral infarction in the spontaneously hypertensive rat. The right middle cerebral artery and common carotid artery were occluded for 0, 1, 2, 3, 4, or 24 hours, and all the animals were sacrificed 24 hours after the onset of ischemia. Cortical infarct volumes and edema volumes were quantified in serial frozen sections of hematoxylin and eosin-stained tissue using image analysis. Upon occlusion, blood flow in the core of the ischemic zone, measured with laser-Doppler flowmetry, fell to a mean +/- standard deviation of 21 +/- 7% of the preocclusion baseline value (n = 26). During the first hour of ischemia, blood flow in the densely ischemic zone rose to 27 +/- 8% of baseline (n = 25). Release of the middle cerebral artery and common carotid artery occlusions rapidly restored cortical blood flow to 213 +/- 83% of baseline (n = 21). Focal ischemia of 1 hour's duration caused little or no infarction, while ischemic intervals of 2 and 3 hours produced successively larger volumes of infarcted cortex. Ischemic intervals of 3-4 hours' duration followed by approximately 20 hours of recirculation yielded infarct volumes that were not significantly different from those after 24 hours of permanent focal ischemia. The results indicate that 3-4 hours of focal cerebral ischemia in this rat model is sufficient to attain maximal infarction and suggest that recirculation or pharmacological interventions after this time will provide little benefit.

  2. Correlations of cerebral blood flow with language function in aphasic patients following cerebral infarction

    Energy Technology Data Exchange (ETDEWEB)

    Yokoyama, Eriko; Nagata, Ken; Uemura, Kazuo [Research Inst. for Brain and Blood Vessels, Akita (Japan)

    1997-04-01

    To elucidate the participation of the brain regions in language function, cerebral blood flow (CBF) which were measured with positron emission tomography (PET) were compared with the language scores based on the standard language test for aphasics in 97 right-handed patients with aphasia due to cerebral infarction. PET studies were performed on 71.4{+-}107.3 days after onset. By the linear regression analysis, the aphasic scores were correlated with the regional CBF from 55 brain regions. CBF from the left frontal, left temporal, and left parietal lobes significantly correlated with language scores of auditory comprehension, speaking, reading, writing, calculation, and repetition. Highly significant correlation was obtained from the left posterior inferior frontal, superior temporal, supramarginal and angular gyri. CBF from the right inferior frontal, right superior temporal, right parahippocampal and right anterior cingulate gyri also correlated with the auditory comprehension, speaking and reading. Accordingly, in addition to the classical language areas which play an essential roles in language function, the extensive areas in the left hemisphere and some part of the right hemisphere may be related to the language processing and recovery from aphasia. (author)

  3. Effects of Electroacupuncture plus Intra-carotid Drug Injection on Rheoencephalogram in Patients with Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    李江明; 胡永均; 童利民; 王大军; 张道敬

    2004-01-01

    Purpose: To investigate the mechanism of electroacupuncture (EA) plus intra-carotid drug injection for treating cerebral infarction. Methods: Rheoencephalogram was recorded with a RG-2B type of bridge rheoencephalograph and findings were compared before and after the treatment. Results: After the treatment, the prolonged rising time was shortened, and the decreased amplitude obviously elevated. Conclusion: The therapy can dilate cerebral blood vessels, increase the cerebral blood flow, and improve the elasticity of cerebral blood vessels, leading to sufficient blood and oxygen supply in the ischemic brain tissues and to restoration of their functions.

  4. A Multidisciplinary Health Care Team's Efforts to Improve Educational Attainment in Children with Sickle-Cell Anemia and Cerebral Infarcts

    Science.gov (United States)

    King, Allison; Herron, Sonya; McKinstry, Robert; Bacak, Stephen; Armstrong, Melissa; White, Desiree; DeBaun, Michael

    2006-01-01

    The primary objective of this study was to improve the educational success of children with sickle-cell disease (SCD) and cerebral infarcts. A prospective intervention trial was conducted; a multidisciplinary team was created to maximize educational resources for children with SCD and cerebral infarcts. Students were evaluated systematically…

  5. Effect of acupuncture on hippocampal Ref-1 expression in cerebral multi-infarction rats.

    Science.gov (United States)

    Liu, Cun-Zhi; Li, Zu-Guang; Wang, De-Jin; Shi, Guang-Xia; Liu, Li-Ying; Li, Qian-Qian; Li, Chong

    2013-03-01

    Redox effector factor (Ref-1) is a sensitive marker for oxidative cellular injury. The aim of this study was to investigate the effects of acupuncture on hippocampal Ref-1 expression in cerebral multi-infarction rats. The rats with reference memory impairment were randomly allocated to three groups: impaired group, acupuncture group and placebo acupuncture group. Moreover, normal group and sham-operated group were set as control groups. Morris water maze test showed that cerebral multi-infarction rats did not present significant changes in spatial working memory performance. Further investigation by immunohistochemistry revealed that acupunctural treatment significantly increased the expression of Ref-1 in the hippocampus of the impaired rats. These findings suggested that the spatial working memory was unaffected in the cerebral multi-infarction rats although spatial reference memory deficits were detected in our previous study; in addition, acupuncture could increase the Ref-1 expression, consequently exerting the anti-oxidant effects.

  6. Thrombolytic therapy. From myocardial to cerebral infarction. The MAST-I Group. Multicentre Acute Stroke Trial.

    Science.gov (United States)

    Candelise, L; Roncaglioni, C; Aritzu, E; Ciccone, A; Maggioni, A P

    1996-02-01

    Thrombolysis is proposed for the acute treatment of cerebral infarction as it is able to recanalize occluded arteries and thus potentially restore normal perfusion of the cerebral parenchyma, but the results concerning the efficacy of this treatment are still inconclusive. However, it has been fully demonstrated that thrombolytic treatment, leads to a significant reduction in mortality, in patients with acute myocardial infarction. Data from all of the pilot studies using SK or tPA treatment in acute stroke are described in this review, which underlines the incidence of hemorrhagic transformation (hemorrhagic infart and parenchymal hematoma) and its possible correlation to clinical worsening. Pharmacological, experimental and clinical studies encourage the carrying out of large-scale clinical trials using thrombolytics in patients with acute cerebral infarction. Significant data relating to ongoing controlled clinical trials will be available in the near future; only after the analysis of these results will it be possible to confirm the efficacy of thrombolytics in acute stroke.

  7. Significance of decreased serum interleukin-10 levels in the progression of cerebral infarction.

    Science.gov (United States)

    Diao, Zeng-Yan; Wang, Cui-Lan; Qi, Hong-Shun; Jia, Guo-Yong; Yan, Chuan-Zhu

    2016-05-01

    Anti-inflammatory cytokine and its serological detection may have an important role in the process of cardiovascular and cerebrovascular diseases. We investigated whether serum interleukin-10 (IL-10) is associated with cerebral infarction or not in the general population. Identified comprehensive searching was performed covering PubMed, EMBASE, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine, and China National Knowledge Infrastructure databases. Two reviewers extracted data and assessed studies independently. Information was extracted separately and classed into Asians and Caucasians. Summary standardized mean differences (SMDs) with 95 % confidence intervals (CI) were used with the utilization of Z test. Nine studies ranged from 2003 to 2014 were collected for meta-analysis. Results identified a negative association between serum IL-10 levels and cerebral infarction (SMD = 1.80, 95 % CI 0.79-2.81, P IL-10 level may be the main risk factor for cerebral infarction in India (SMD = 1.44, 95 % CI 1.13-1.75, P IL-10 levels were negatively correlated with cerebral infarction in Asians (SMD = 2.52, 95 % CI 0.47-4.57, P = 0.016), while not in Caucasians (P > 0.05). The lower serum IL-10 concentration was significantly associated with an increased likelihood of cerebral infarction in this meta-analysis. More prospective studies should be conducted to provide stronger evidence justifying the use of IL-10 as new biomarker to identify a predisposition toward cerebral infarction.

  8. Diagnosis of acute cerebral infarction using diffusion-weighted imaging by low field (0.2 T) magnetic resonance image

    Energy Technology Data Exchange (ETDEWEB)

    Okuyama, Tohru; Sasamori, Yumiko; Takahashi, Hachisaburou; Mikami, Juniti; Ishii, Yuuko; Okada, Kinya; Shirafuji, Naoko; Kashiwakura, Takeshi [Takahashi Neurosurgical Hospital, Sapporo (Japan)

    2000-09-01

    The purpose of this study is to confirm the diagnosis of acute cerebral infarction on diffusion-weighted imaging using low field (0.2 T) magnetic resonance image (MRI). Acute cerebral infarctions in 51 patients were examined on diffusion-weighted imaging using low field MRI within 48 hours after clinical symptoms. Diffusion-weighted imaging was examined using line scan method. Twenty-four cases were cortical infarction, and twenty-two cases were perforating infarction. In five cases out of 51 cases, ischemic regions were not detected as abnormal high signal intensity area on diffusion-weighted imaging. Four cases of no abnormal detection were transient ischemic attack, and the other one was a perforating infarction. The earliest detection time in cortical infarction cases was 1 hour and 20 minutes. On the other hand, the earliest detection time in perforating infarction cases was 3 hours. Detective ability for acute cerebral infarction on diffusion-weighted imaging by low field MRI was depending on both size and lesion of infarction. That is to say, either small size or brain stem infarction was hard to detect. Thin slice and vertical slice examination for the infarction may improve to diagnose in low field MRI. Our conclusion is acute cerebral infarction was able to be diagnosed on diffusion-weighted imaging by low field as well as high field MRI. (author)

  9. Morphology of platelet Golgi apparatus and their significance after acute cerebral infarction.

    Science.gov (United States)

    Lu, Wei; Xu, Dong; Tu, Ranran; Hu, Zhiping

    2013-08-15

    Blood samples were harvested from the antecubital vein of 20 fasting patients with acute cerebral infarction at 1, 7 and 15 days after onset to prepare blood platelet suspension. Fasting antecubital vein blood was collected from an additional 20 normal adults as controls. Under transmission tron microscope, platelet Golgi tubules and vesicles became significantly thickened, enlarged, and irregular after acute cerebral infarction. Alpha granules in platelets significantly reduced in number, especially 1 day after cerebral infarction. Under immunoelectron microscopy, a few alpha granules aggregated around Golgi tubules and vesicles after infarction. These results suggested that platelet Golgi apparatus displayed significant morphological changes, which were possibly associated with enhanced synthetic and secretory functions of activated platelets after acute cerebral infarction. This study used Golgi apparatus blocking agent Brefeldin A to block Golgi apparatus in an aim to study the effects of Golgi apparatus on CD40L expression on the surface of activated platelets. Flow cytometry revealed that CD40L expression on activated platelet surfaces decreased significantly when Golgi apparatus was blocked, which indicated that Golgi apparatus participated in the synthesis and transport of CD40L to the platelet surface.

  10. Morphology of platelet Golgi apparatus and their significance after acute cerebral infarction***

    Institute of Scientific and Technical Information of China (English)

    Wei Lu; Dong Xu; Ranran Tu; Zhiping Hu

    2013-01-01

    Blood samples were harvested from the antecubital vein of 20 fasting patients with acute cerebral infarction at 1, 7 and 15 days after onset to prepare blood platelet suspension. Fasting antecubital vein blood was col ected from an additional 20 normal adults as controls. Under transmission tron microscope, platelet Golgi tubules and vesicles became significantly thickened, enlarged, and irregular after acute cerebral infarction. Alpha granules in platelets significantly reduced in number, especial y 1 day after cerebral infarction. Under immunoelectron microscopy, a few alpha granules aggregated around Golgi tubules and vesicles after infarction. These results suggested that platelet Golgi apparatus displayed significant morphological changes, which were possibly associated with enhanced synthetic and secretory functions of activated platelets after acute cerebral infarction. This study used Golgi apparatus blocking agent Brefeldin A to block Golgi apparatus in an aim to study the effects of Golgi apparatus on CD40L expression on the surface of activated platelets. Flow cytometry revealed that CD40L expression on activated platelet surfaces decreased significantly when Golgi apparatus was blocked, which indicated that Golgi apparatus participated in the syn-thesis and transport of CD40L to the platelet surface.

  11. Acupuncture Treatment of Acute Cerebral Infarction by the‘Three-Step Needling’Method

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Objective: To observe the therapeutic effects of acupuncture treatment by the‘Three-Step Needling’Method for acute cerebral infarction. Method: While receiving the routine medical treatment, 68 cases were treated by the acupuncture method of‘Three-Step Needling’. Results: 27 of the 68 cases were basically cured, 23markedly improved, 15 improved, and 3 failed, the total effective rate being 95.59%. Conclusion: The acupuncture method of‘Three-Step Needling’can give quite good therapeutic effects for acute cerebral infarction.

  12. A Case Associated with Comorbidities Among Cerebral Infarction, Idiopathic Thrombocytopenic Purpura, and Triple X Syndrome

    Directory of Open Access Journals (Sweden)

    Hanjun Kim

    2014-06-01

    Full Text Available A 46-year-old female presented to the emergency room due to the chief complaint of left-sided weakness. By imaging study, she was diagnosed with cerebral infarction. Thrombolytic and antiplatelet agents were not considered due to the “golden hour” for treatment having passed and a low platelet count. The peripheral blood smear, bone marrow biopsy, and aspirate findings were consistent with immune thrombocytopenic purpura. The chromosome analysis revealed the 47,XXX karyotype. To the best of our knowledge, this is the first case report associated with the comorbidities of cerebral infarction, idiopathic thrombocytopenic purpura, and triple X syndrome.

  13. Malignant Hemispheric Cerebral Infarction Associated with Idiopathic Systemic Capillary Leak Syndrome

    Directory of Open Access Journals (Sweden)

    Kei Miyata

    2013-10-01

    Full Text Available Idiopathic systemic capillary leak syndrome (ISCLS is a rare condition that is characterized by unexplained episodic capillary hyperpermeability due to a shift of fluid and protein from the intravascular to the interstitial space. This results in diffuse general swelling, fetal hypovolemic shock, hypoalbuminemia, and hemoconcentration. Although ISCLS rarely induces cerebral infarction, we experienced a patient who deteriorated and was comatose as a result of massive cerebral infarction associated with ISCLS. In this case, severe hypotensive shock, general edema, hemiparesis, and aphasia appeared after serious antecedent gastrointestinal symptoms. Progressive life-threatening ischemic cerebral edema required decompressive hemicraniectomy. The patient experienced another episode of severe hypotension and limb edema that resulted in multiple extremity compartment syndrome. Treatment entailed forearm and calf fasciotomies. Cerebral edema in the ischemic brain progresses rapidly in patients suffering from ISCLS. Strict control of fluid volume resuscitation and aggressive diuretic therapy may be needed during the post-leak phase of fluid remobilization.

  14. Protective Effects of Overexpression of bcl-xl Gene on Local Cerebral Infarction in Transgenic Mice Undergoing Permanent Occlusion of Middle Cerebral Artery

    Institute of Scientific and Technical Information of China (English)

    Furong WANG; Yongsheng JIANG; Suming ZHANG; Wenwu XIAO; Suiqiang ZHU

    2008-01-01

    In order to investigate the protective effects of the overexpression of bcl-xl gene on local cerebral infarction in the transgenic mice subject to permanent occlusion of middle cerebral artery, the models of bcl-xl transgenic mice were established and subjected to cerebral infarction by intralu- minal occlusion of the middle cerebral artery. The infarct volume and the neurological scores were observed and comparison between the wild type mice and the transgenic mice was made. It was found that the infarct volume and the neurological scores in the transgenic mice were significantly decreased as compared with those in the wild type mice. It was suggested that the overexpression of bcl-xl gene in transgenic mice could reduce the infarct volume and improve the neurological function of the mice.

  15. A Case of Apoplexy of Rathke’s Cleft Cyst Followed by Cerebral Infarction

    Directory of Open Access Journals (Sweden)

    Yu-ichiro Ohnishi

    2015-01-01

    Full Text Available Rathke’s cleft cyst (RCC apoplexy is a rare clinical entity. We report a case of apoplexy of an RCC followed by cerebral infarction. A 67-year-old woman was found lying on the street unconscious. She had fallen from her motorbike. On referral to our hospital she gradually regained consciousness and presented with no neurological deficits. CT showed a round and slightly hyperdense area in the suprasellar region. However, the attending physician did not find this abnormal finding on CT and the patient was discharged the same day. Thirteen days after the first emergency visit she developed left hemiparesis and dysarthria. CT showed a round hypodense area in the suprasellar region. The change of the density in the suprasellar region on CT suggested the pituitary apoplexy. CT also showed a low density area in the territory of the right middle cerebral artery, which indicated the cerebral infarction. MR angiography revealed poor visibility and stenotic changes of right middle cerebral arteries. Transsphenoidal surgery was performed. Histopathological findings confirmed a hemorrhagic RCC. Postoperative MR angiography showed that the visibility and stenosis of right middle cerebral arteries were recovered. This is the rare case of apoplexy of an RCC followed by cerebral infarction.

  16. Continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischemia.

    Science.gov (United States)

    Jacewicz, M; Brint, S; Tanabe, J; Pulsinelli, W A

    1990-01-01

    Focal cerebral infarction and edema were measured in rats (Wistar, Fisher 344, and spontaneously hypertensive strains) pretreated with nimodipine (2 micrograms/kg/min i.v.) or its vehicle and subjected to the tandem occlusion of the middle cerebral and common carotid arteries. Animals awoke from anesthesia 10-15 min after onset of ischemia and continued to receive treatment over a 24-h survival period. Cortical infarction and edema were quantified by image analysis of frozen brain sections processed for histology. Nimodipine-treated rats developed 20-60% smaller cortical infarct volumes than controls (p less than 0.002). Cortical edema was reduced proportionately to the decrease in infarct volume and constituted approximately 36% of the infarct volume. Nimodipine caused a mild hypotensive response that did not aggravate ischemic brain damage. The results indicate that continuous nimodipine treatment, started before induction of focal cerebral ischemia, can attenuate ischemic brain damage and edema as late as 24 h after the onset of ischemia.

  17. EXPERIMENTAL STUDY ON PLASTICITY OF PROLIFERATED NEURAL STEM CELLS IN ADULT RATS AFTER CEREBRAL INFARCTION

    Institute of Scientific and Technical Information of China (English)

    Bo Zhang; Ren-zhi Wang; Zhi-gang Lian; Yang Song; Yong Yao

    2006-01-01

    Objective To investigate whether there is endogenous neural stem cell proliferation and whether these proliferated neural stem cells represent neural plasticity in the adult rats after cerebral infarction.Methods Cerebral infarction models of rats were established and the dynamic expression of bromodeoxyuridine (BrdU), BrdU/polysialylated neural cell adhesion molecule (PSA-NCAM) were determined by immunohistochemistry and immunofluorescence staining. BrdU was used to mark dividing neural stem cells. PSA-NCAM was used to mark the plasticity of neural stem cells.Results Compared with controls, the number of BrdU-positive cells in the subventricular zone (SVZ) and hippocampus increased significantly at 1st day after cerebral infarction (P<0.05), reached maximum at 7th day, decreased markedly at 14th day, but it was still elevated compared with that of the controls (P<0.05). The number of BrdU-labeled with PSA-NCAM-positive cells increased significantly at 7th day (P<0.05 ), reached maximum at 14th day,markedly decreased at 28th day, but it was still elevated compared with that of the controls (P<0.05). It was equal to 60% of the number of BrdU-positive cells in the same period.Conclusion Cerebral infarction may stimulate the proliferation of endogenous neural stem cells in situ and most proliferated neural stem cells represent neural plasticity.

  18. Circulating cerebral S100B protein is associated with depressive symptoms following myocardial infarction

    NARCIS (Netherlands)

    Tulner, D.M.; Smith, O.R.F.; de Jonge, P.; van Melle, J.P.; Slomp, J.; Storm, H.; Quere, M.; den Boer, J.A.; Honig, A.; Korf, J.

    2009-01-01

    Background: Prevalence of depressive symptoms in the post-myocardial infarction (MI) period varies from 8 to 30%. Cerebral damage after MI, caused by transient ischemia, an inflammatory response or both, may contribute to development of post-MI depression. S100B is an established protein marker of c

  19. Relationship between Helicobacterpylori bearing the cytotoxin associated gene-A and cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Li Yajun; An Eenglian; Zhu Yongqing; MaoXiaolin; Wang Yumei

    2000-01-01

    Objective To explore the relationship between virulent Helicobacter pylori strains infection and cerebral infarction. Method We assessed the prevalence of infection by strains bearing the cytotoxin -associated gene-A(Cag-A),a strong virulence factor ,in 83 patients with cerebral infarction and in 71 age- and sex-matched controls with similar social background. Result Prevalence of Helicobacter pylori infection was significantly higher in patients than in controls(78.3% versus 56.3%,p<0.05),with an odds ratio of 2.8(95%CI,1.46 to 5.36) adjusted for age, sex, main stroke factors. Patients with cerebral infarction also had a higher prevalence of Cag-A-positive strains(45.8% versus 19.7%, P<0.01),with an adjusted odds ratio of 3.43(95%CI 1.5 to 7.24).Conclusion It was suggested that chronic Helicobacter pylori infection, especially Cag-A-positive strains infection is an independent risk factor for cerebral infarction.

  20. Quality of life after surgical decompression for space-occupying middle cerebral artery infarction: systematic review

    NARCIS (Netherlands)

    Middelaar, T. van; Nederkoorn, P.J.; Worp, H.B. van der; Stam, J.; Richard, E.

    2015-01-01

    BACKGROUND AND PURPOSE: In patients with space-occupying middle cerebral artery infarction, surgical decompression strongly reduces risk of death and increases the chance of a favorable outcome. This comes at the expense of an increase in the risk of survival with (moderately) severe disability. We

  1. Fluid Intake Related to Brain Edema in Acute Middle Cerebral Artery Infarction.

    Science.gov (United States)

    Dharmasaroja, Pornpatr A

    2016-02-01

    Evidence of the appropriate amount of fluid intake during the first few days after acute stroke was scarce. Concerns were raised in patients with acute malignant middle cerebral infarction, who tended to have malignant brain edema later. The purpose of the study was to evaluate the effect of fluid intake on the occurrence of malignant brain edema in patients with acute middle cerebral artery infarction. Patients with acute middle cerebral artery infarction who had National Institute of Health Stroke Scale (NIHSS) score of at least 15 were included. Baseline characteristics and amount of fluid intake during the first few days were compared in patients with and without malignant brain edema. One hundred ninety-three patients were studied. Mean NIHSS score was 20. Malignant brain edema occurred in 69 patients (36%). Higher amount of fluid intake (>1650 ml or >28 ml/kg/day or >93% of daily maintenance fluid) showed a significant association with malignant brain edema (OR = 13.86, 95% CI 5.11-37.60, p value edema, 39 patients (39/65, 60%) died and only 11% (7/65 patients) had favorable outcome. High amount of fluid intake in the first few days of acute middle cerebral infarction was related to the occurrence of malignant brain edema.

  2. Imaging Findings Associated with Space-Occupying Edema in Patients with Large Middle Cerebral Artery Infarcts

    NARCIS (Netherlands)

    Horsch, A D; Dankbaar, J W; Stemerdink, T A; Bennink, E; van Seeters, T; Kappelle, L J; Hofmeijer, J; de Jong, H W; van der Graaf, Y; Velthuis, B K

    2016-01-01

    BACKGROUND AND PURPOSE: Prominent space-occupying cerebral edema is a devastating complication occurring in some but not all patients with large MCA infarcts. It is unclear why differences in the extent of edema exist. Better knowledge of factors related to prominent edema formation could aid treatm

  3. Imaging characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)

    Science.gov (United States)

    Stojanov, Dragan; Aracki-Trenkic, Aleksandra; Vojinovic, Slobodan; Ljubisavljevic, Srdjan; Benedeto-Stojanov, Daniela; Tasic, Aleksandar; Vujnovic, Sasa

    2015-01-01

    Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is an autosomal dominant vascular disorder. Diagnosis and follow-up in patients with CADASIL are based mainly on magnetic resonance imaging (MRI). MRI shows white matter hyperintensities (WMHs), lacunar infarcts and cerebral microbleeds (CMBs). WMHs lesions tend to be symmetrical and bilateral, distributed in the periventricular and deep white matter. The anterior temporal lobe and external capsules are predilection sites for WMHs, with higher specificity and sensitivity of anterior temporal lobe involvement compared to an external capsule involvement. Lacunar infarcts are presented by an imaging signal that has intensity of cerebrospinal fluid in all MRI sequences. They are localized within the semioval center, thalamus, basal ganglia and pons. CMBs are depicted as focal areas of signal loss on T2 images which increases in size on the T2*-weighted gradient echo planar images (“blooming effect”). PMID:25725137

  4. Central retinal artery occlusion with concomitant ipsilateral cerebral infarction after cosmetic facial injections.

    Science.gov (United States)

    Hong, Jeong-Ho; Ahn, Seong Joon; Woo, Se Joon; Jung, Cheolkyu; Chang, Jun Young; Chung, Jin-Heon; Han, Moon-Ku

    2014-11-15

    We report 2 cases of central retinal artery occlusion with concomitant ipsilateral cerebral infarction after cosmetic facial injections and a literature review. The 2 patients were two healthy women, in which cosmetic facial injections with autologous fat and filler were performed, respectively. The patients had no light perception at the final visit and their conditions led to memory retrieval disturbance in case 1 and right arm weakness, dysarthria, facial palsy, and ophthalmoplegia in case 2. Neuroimaging showed multifocal small infarctions in the ipsilateral frontal lobe with occlusion of the ophthalmic artery in case 1 and multiple infarctions in the ipsilateral anterior and middle cerebral artery territories with subsequent hemorrhagic transformation in case 2. Poor visual prognosis and neurological complications can occur in healthy adults undergoing cosmetic facial injection, and all patients should be informed of this risk before the procedure.

  5. [A case of central alveolar hypoventilation syndrome associated with cerebral infarction].

    Science.gov (United States)

    Yamada, A; Kamoda, M; Ikezoe, K; Tsukaguchi, M; Katanaka, J; Deguchi, K; Miki, H; Takeuchi, H

    1993-03-01

    Central alveolar hypoventilation syndrome (CAH), or Ondine's curse, is a very rare disease characterized by dysfunction of respiratory center in the brain stem. Here, we report a case of CAH associated with cerebral infarction. A 59-year-old man developed right facial sensory deficit at age 56. Then, the facial sensory deficit spread to the left side and dysarthria and dysphagia also developed. Since age 58, he often developed respiratory failure and consciousness disturbance. Arterial blood gas analysis revealed alveolar hypoventilation and respiratory acidosis. Disorders of peripheral organs such as lung, airway, thorax and neuromuscular diseases were ruled out. Brain MRI showed cerebral infarction in the brain stem. We diagnosed him as CAH associated with brain stem infarction.

  6. Mild focal cerebral ischemia in the rat. The effect of local temperature on infarct size

    DEFF Research Database (Denmark)

    Hildebrandt-Eriksen, Elisabeth S; Christensen, Thomas; Diemer, Nils Henrik

    2002-01-01

    We aimed at investigating a new model of mild focal cerebral ischemia in rats with repeated, noninvasive magnetic resonance scanning combined with histology. Magnetic resonance imaging yielded information about infarct development enabling us to test the putative growth of the infarct over time....... The effect of local temperature at the occlusion site in this model was furthermore tested. Thirty-three Wistar rats were subjected to 30 min of simultaneous common carotid artery and distal middle cerebral artery occlusion or sham treatment. Animals were magnetic resonance-scanned repeatedly between day one...... and day 14 after surgery, then sacrificed, and paraffin brain sections stained. All animals scanned 24 h after reperfusion showed an area of edema in the affected cortex, which later was identified as an infarct. Animals with a temperature of 33.9 +/- 1.5 degrees C at the MCA site (hypothermic) showed...

  7. The Effect of Acupuncture on Plasma Endothelin Content in Cerebral Infarction Patients——A Clinical Study

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective: To observe the effect of acupuncture on content of plasma endothelin in cerebral infarction patients. Methods: The plasma endothelin content in cerebral infarction patients was observed before and after acupuncture, which was compared with that of the medication group and the healthy subjects. Results: Before treatment, the content of plasma endothelin in cerebral infarction patients was significantly higher than that of the healthy subjects (P<0.01); after acupuncture treatment, the content greatly decreased (P<0.01), and there was a statistically significant difference between the acupuncture group and the medication group (P<0.05). Conclusion: Acupuncture may decrease the content of plasma endothelin in the cerebral infarction patients, improve the vascular elasticity, and improve the cerebral circulation of blood.

  8. Moringa Oleifera Lam Mitigates Oxidative Damage and Brain Infarct Volume in Focal Cerebral Ischemia

    Directory of Open Access Journals (Sweden)

    Woranan Kirisattayakul

    2012-01-01

    Full Text Available Problem statement: At present, the therapeutic outcome of cerebral ischemia is still not in the satisfaction level. Therefore, the preventive strategy is considered. Based on the protective effect against oxidative damage of Moringa oleifera Lam. Leaves extract, we hypothesized that this plant extract might protect against cerebral ischemia, one of the challenge problems nowadays. In order to test this hypothesis, we aimed to determine the protective effect of M.oleifera leaves extract in animal model of focal cerebral ischemia induced by permanent occlusion of right middle cerebral artery. Approach: Male Wistar rats, weighing 300-350 g, were orally given the extract once daily at doses of 100, 200 and 400 mg kg-1 BW at a period of 2 weeks, then, they were permanently occluded the right Middle Cerebral Artery (MCAO. The animals were assessed the cerebral infarction volume and oxidative damage markers including MDA level and the activities of SOD, CAT and GSHPx enzymes at 24 h after occlusion. Results: Rats subjected to M.oleifera extract at all doses used in this study significantly decreased brain infarct volume both at cortical and subcortical structures in accompany with the elevation of SOD activity in both hippocampus and striatum while only the rats exposed to the extract at doses of 100 and 400 mg kg-1 BW showed the increased GSHPx activity in hippocampus. No the changes were observed. Therefore, our results demonstrates the potential benefit of M.oleifera leaves to decrease oxidative stress damage and brain infarct volume. Conclusion: This study is the first study to demonstrate the neuroprotective effect against focal cerebral ischemia of M.oleifera leaves. It suggests that M.oleifera may be served as natural resource for developing neuroprotectant against focal cerebral ischemia. However, the precise underlying mechanism and possible active ingredient are still required further study.

  9. Therapeutic imaging window of cerebral infarction revealed by multisequence magnetic resonance imaging An animal and clinical study

    Institute of Scientific and Technical Information of China (English)

    Hong Lu; Hui Hu; Zhanping He; Xiangjun Han; Jing Chen; Rong Tu

    2012-01-01

    In this study, we established a Wistar rat model of right middle cerebral artery occlusion and observed pathological imaging changes (T2-weighted imaging [T2WI], T2FLAIR, and diffusion-weighted imaging [DWI]) following cerebral infarction. The pathological changes were divided into three phases: early cerebral infarction, middle cerebral infarction, and late cerebral infarction. In the early cerebral infarction phase (less than 2 hours post-infarction), there was evidence of intracellular edema, which improved after reperfusion. This improvement was defined as the ischemic penumbra. In this phase, a high DWI signal and a low apparent diffusion coefficient were observed in the right basal ganglia region. By contrast, there were no abnormal T2WI and T2FLAIR signals. For the middle cerebral infarction phase (2–4 hours post-infarction), a mixed edema was observed. After reperfusion, there was a mild improvement in cell edema, while the angioedema became more serious. A high DWI signal and a low apparent diffusion coefficient signal were observed, and some rats showed high T2WI and T2FLAIR signals. For the late cerebral infarction phase (4–6 hours post-infarction), significant angioedema was visible in the infarction site. After reperfusion, there was a significant increase in angioedema, while there was evidence of hemorrhage and necrosis. A mixed signal was observed on DWI, while a high apparent diffusion coefficient signal, a high T2WI signal, and a high T2FLAIR signal were also observed. All 86 cerebral infarction patients were subjected to T2WI, T2FLAIR, and DWI. MRI results of clinic data similar to the early infarction phase of animal experiments were found in 51 patients, for which 10 patients (10/51) had an onset time greater than 6 hours. A total of 35 patients had MRI results similar to the middle and late infarction phase of animal experiments, of which eight patients (8/35) had an onset time less than 6 hours. These data suggest that defining the

  10. Magnetic resonance perfusion imaging evaluation in perfusion abnormalities of the cerebellum after supratentorial unilateral hyperacute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Pan Liang; Yunjun Yang; Weijian Chen; Yuxia Duan; Hongqing Wang; Xiaotong Wang

    2012-01-01

    Magnetic resonance imaging (MRI) data of 10 patients with hyperacute cerebral infarction (≤ 6 hours) were retrospectively analyzed. Six patients exhibited perfusion defects on negative enhancement integral maps, four patients exhibited perfusion differences in pseudo-color on mean time to enhance maps, and three patients exhibited perfusion differences in pseudo-color on time to minimum maps. Dynamic susceptibility contrast-enhanced perfusion weighted imaging revealed a significant increase in region negative enhancement integral in the affected hemisphere of patients with cerebral infarction. The results suggest that dynamic susceptibility contrast-enhanced perfusion weighted imaging can clearly detect perfusion abnormalities in the cerebellum after unilateral hyperacute cerebral infarction.

  11. Meta-analysis of defibrase in treatment of acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Background Fibrinogen-depleting agents are promising in the treatment of cerebral ischemic disease. They were studied by many trials, and the outcomes were different because of different regimens and different doses. In this study, we assessed the efficacy and safety of defibrase on acute cerebral infarction in China.Methods A search using Chinese hospital knowledge database (CHKD) and MEDLINE database for randomized controlled trials was carried out. A CHKD (1994 June 2005) search was performed with the keyword "defibrase", then a second search for the keyword "acute cerebral infarction"; a MEDLINE search (1950 June 2005) was performed with the following keywords: [(cerebral ischemia), OR (acute cerebral infarction), OR (stroke)], AND [defibrase]. Meta-analysis was performed with RevMan software 4.2.Results Included were 14 studies comparing the efficiency and safety of defibrase with other drugs in the treatment of acute cerebral infarction. Patients' records were pooled (total 646 patients; defibrase, n=328, no defibrase n=318). Neurological deficit score (NDS) before treatment showed weighted mean differences (WMD)=0.95, 95% confidence interval (CI)= (-0.60, 2.50), P=0.23; NDS after treatment showed WMD=-2.20, 95% CI= (-4.21, -0.18), P=0.03; Barthel index at 3 months showed WMD=4.45, 95% CI= (-0.13, 9.03), P=0.06; the plasma fibrinogen level before treatment showed WMD=0.02, 95% CI= (-0.16, 0.19), P=0.86; plasma fibrinogen level after treatment showed WMD=-1.51, 95% CI= (-1.88, -1.15), P<0.00 001. Conclusions With the given dose and regimen of defibrase in China, defibrase may play a role of anticoagulation. It might inhibit the progression of stroke and prevent the recurrence of stroke.

  12. Whether chronic bronchitis is an independent risk factor for cerebral infarction in the elderly 1:1 case paired study

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: The inflammatory reaction already becomes an important risk factor of causing acute cerebral infarction; however, the correlation between chronic bronchitis and senile cerebral infarction is still unclear.OBJECTIVE: To study whether the chronic bronchitis is the risk factor for senile cerebral infarction.DESIGN: 1:1 pair, case contrast, and risk factor study.SETTINGS: Department of Respiratory Medicine, Third Hospital of Tangshan; Department of Neurology,Affiliated Hospital of North China Coal Medical College.PARTICIPANTS: A total of 147 patients with acute cerebral infarction who were regarded as case group were selected from Department of Neurology, the Third Hospital of Tangshan from January 2004 to December 2006. All patients met the diagnostic criteria of the Fourth National Cerebrovascular Diseases Meeting. There were 87 males and 60 females, and their ages ranged from 65 to 83 years. Based on 1∶1 pair study, another 147 subjects without cerebrovascular disease were regarded as control group. Except the diseases about infection, there were 73 males and 74 females, and their ages ranged from 62 to 81 years. All subjects provided the confirm consent and agreed with the coordinate experiment.METHODS: ① Questionnaire of risk factor of cerebral infarction was designed to measure the following items: chronic bronchitis, hypertension, diabetes mellitus, hyperlipemia, coronary heart disease, primary cerebral infarction/transient ischemic attack and history of smoking. ② Cerebral infarction was regarded as the dependent variance, while chronic bronchitis, hypertension, diabetes mellitus, hyperiipemia, primary cerebral infarction/transient ischemic attack, coronary heart disease and smoking were regarded as the independent variance for multiple regression analysis.MAIN OUTCOME MEASURES: Risk factors of senile cerebral infarction.RESULTS: All 147 patients with acute cerebral infarction and 147 subjects without cerebrovascular diseases were involved in

  13. The CBF threshold and dynamics for focal cerebral infarction in spontaneously hypertensive rats.

    Science.gov (United States)

    Jacewicz, M; Tanabe, J; Pulsinelli, W A

    1992-05-01

    Two strategies were used to estimate the blood flow threshold for focal cerebral infarction in spontaneously hypertensive rats (SHRs) subjected to permanent middle cerebral artery and common carotid artery occlusion (MCA/CCAO). The first compared the volume of cortical infarction (24 h after ischemia onset) to the volumes of ischemic cortex (image analysis of [14C]iodoantipyrine CBF autoradiographs) perfused below CBF values less than 50 (VIC50) and less than 25 ml 100 g-1 min-1 (VIC25) at serial intervals during the first 3 h of ischemia. The infarct process becomes irreversible within 3 h in this model. In the second, measurements of CBF at the border separating normal from infarcted cortex at 24 h after ischemia onset were used as an index of the threshold. During the first 3 h of ischemia, VIC50 increased slightly to reach a maximum size at 3 h that closely matched the 24 h infarct volume. VIC25, in contrast, consistently underestimated the infarct volume by a factor of 2-3. CBF at the 24 h infarct border averaged 50 ml 100 g-1 min -1. Taken together, the results indicate that the CBF threshold for infarction in SHRs approaches 50 ml 100 g-1 min-1 when ischemia persists for greater than or equal to 3 h. This threshold value is approximately three times higher than in primates. Since cortical neuronal density is also threefold greater in rats than in primates, the higher injury threshold in the rat may reflect a neuronal primacy in determining the brain's susceptibility to partial ischemia.

  14. Relationship between serum S-100 protein level and ischemic damage degree in patients with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    HE Ming-li; XU Bing-chao; HUANG Guo-sheng

    2005-01-01

    Objective: To investigate the time course of serum S-100 concentrations of patients with acute cerebral infarction,and their relation with the clinical data and the prognosis. Methods: Serum S-100 levels were serially determined in 35 patients with acute cerebral infarction within 12 h, at 24 h and day 2, 3, 4, 5,7 and 10 after acute cerebral infarction and in 20 age- and sex-matched control subjects. An S-100 content assay was performed using a two-site radioimmunoassay technique. The clinical status was assessed using NIH Stroke Scale. The functional deficit at 4 weeks after acute cerebral infarction was scored using the modified Rankin scale. A cranial computed tomography was performed initially. Results: Elevated concentrations of S100 (>0.2 μg/L) were observed in 29 of 36 patients with acute cerebral infarction,but none of the control subjects. The S-100 peak levels were at day 2 and 3 after acute cerebral infarction and were significantly high in those patients with severe neurological deficit at admission, with extensive infarction or with space-occupying effect of ischemic edema as compared with the rest of the populations. Conclusion: Serum S-100 level assay can be used as a peripheral marker of ischemic brain damage, and may be helpful for evaluation of therapeutic effects in acute ischemic stroke.

  15. Benzodiazepine receptor imaging with iomazenil SPECT in aphasic patients with cerebral infarction

    Energy Technology Data Exchange (ETDEWEB)

    Koshi, Yasuhiko; Kitamura, Shin; Ohyama, Masashi [Nippon Medical School, Tokyo (Japan)] (and others)

    1999-08-01

    To investigate the relationship between prognosis of aphasia and neuronal damage in the cerebral cortex, we evaluated the distribution of central-type benzodiazepine receptor (BZR) binding in post-stroke aphasics with [{sup 123}I]iomazenil and SPECT. We performed iomazenil SPECT in six aphasic patients (aged from 45 to 75 years; all right-handed) with unilateral left cerebral infarction. Three patients showed signs of Broca's aphasia and the other three Wernicke's aphasia. Cerebral blood flow (CBF) imaging was performed with [{sup 123}I]iodoamphetamine (IMP). The regions of interest (ROIs) on both images were set in the cerebral cortex, cerebellar cortex and language relevant area in both hemispheres. Three patients were classified in the mild prognosis group and the other three in the moderate prognosis group. The left language-relevant area was more closely concerned with the difference in aphasic symptoms than the right one in both BZR and CBF distribution, but the ipsilateral to the contralateral ratio (I/C ratio) in the language-relevant areas in the BZR distribution was significantly lower in the moderate prognosis group than in the mild prognosis group, although no difference was seen for these values between the two groups in the CBF distribution. These results suggest that BZR imaging, which makes possible an increase in neuronal cell viability in the cerebral cortex, is useful not only for clarifying the aphasic symptoms but also for evaluating the prognosis of aphasia in patients with cerebral infarction. (author)

  16. MTHFR homozygous mutation and additional risk factors for cerebral infarction in a large Italian family.

    Science.gov (United States)

    Del Balzo, Francesca; Spalice, Alberto; Perla, Massimo; Properzi, Enrico; Iannetti, Paola

    2009-01-01

    Several cases with cerebral infarctions associated with the C677T mutation in the methylenetetrahydrofolate reductase gene (MTHFR) have been reported. Given the large number of asymptomatic individuals with the MTHFR mutation, additional risk factors for cerebral infarction should be considered. This study describes a large family with the MTHFR mutation and a combination of heterozygous factor V Leiden mutations and different additional exogenous and endogenous thrombogenic risk factors. Psychomotor retardation and a left fronto-insular infarct associated with the MTHFR mutation together with diminished factor VII and low level of protein C was documented in the first patient. In the second patient, generalized epilepsy and a malacic area in the right nucleus lenticularis was associated with the MTHFR mutation and a low level of protein C. In the third patient, right hemiparesis and a left fronto-temporal porencephalic cyst were documented, together with the MTHFR mutation and hyperhomocysteinemia. An extensive search of additional circumstantial and genetic thrombogenic risk factors should be useful for prophylaxis and prognosis of infants with cerebral infarctions associated with the MTHFR mutation and of their related family members.

  17. Cerebral infarction mimicking brain tumor on Tc-99m tetrofosmin brain SPECT imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Soon [College of Medicine, Dongguk Univ., Gyeongju (Korea, Republic of); Zeon, Seok Kil; Won, Kyoung Sook [School of Medicine, Keimyung Univ., Daegu (Korea, Republic of)

    2004-06-01

    A 43-year-old man was presented with persistent headache for two weeks. T2 weighted MR imaging showed high signal intensity with surrounding edema in the left frontal lobe. These findings were considered with intracranial tumor such as glioma or metastasis. Tc-99m tetrofosmin SPECT showed focal radiotracer accumulation in the left frontal lobe. The operative specimen contained cerebral infarction with organizing leptomeningeal hematoma by pathologist. Another 73-year-old man was hospitalized for chronic headache. Initial CT showed ill-defined hypodensity with mass effect in the right parietal lobe. Tc-99m tetrofosmin SPECT showed focal radiotracer uptake in the right parietal lobe. These findings were considered with low-grade glioma or infarction. Follow-up CT after 5 months showed slightly decreased in size of low density in the right parietal lobe, and cerebral infarction is more likely than others. Tc-99m tetrofosmin has been proposed as a cardiotracer of myocardial perfusion imaging and an oncotropic radiotracer. Tc-99 tetrofosmin SPECT image provides a better attractive alternative agent than TI-201 as a tumor-imaging agent, with characteristics such as high-energy flux, short half-life, favorable biodistribution, dosimetry and lower background radioactivity. We have keep in mind on the analysis of Tc-99m tetrofosmin imaging when cerebral infarction is being differentiated from brain tumor.

  18. [Hemiplegia in posterior cerebral artery infarctions: analysis of various responsible mechanisms].

    Science.gov (United States)

    Ortiz, N; Barraquer Bordas, L; Dourado, M; Rey, A; Avila, A

    1993-01-01

    When cerebral infarction determines hemiplegia or hemiparesia which accompany a hemilateral sensitive deficit and hemianopsia and even neuropsychologic symptoms (aphasic alterations in the case of injury to the left hemisphere, heminegligence and anosognosy in the case of injury to the right hemisphere) the involvement of a sylvian artery syndrome is usually considered. Nonetheless, recent contributions have reported that such symptoms may appear in infarctions of the territory of the posterior cerebral artery. Two clinical-radiologic observations in this line are presented. Nuclear magnetic resonance demonstrated injury to the posterior arm of the internal capsule in one case and in the other the lesion developed over three times, in the latter of which injury to the cerebral peduncle was produced causing hemiparesia. The authors emphasize that hemiplegia or hemiparesia in some infarctions of the posterior cerebral artery may be due to 1) mesencephalic infarction in the posterior plane of the retromamillar Foix and Hillemand pediculum (or G. Lazorthes interpedunculum), 2) infarction or "ischemic penumbra" in the internal capsule by involvement of any of the perforating branches of the posterior cerebrum irrigating the thalamus, except for the medial posterior choroid artery or even of the Foix and Hillemand thalamus-tuberian pediculum (or Lazorthes inferior and anterior) which principally initiates at the posterior communicating branch with a fragment of the posterior branch of the internal capsule perhaps not always being under its control. In this case, the thrombus occupying the posterior cerebrum may extend to the cited communicating branch or a hemodynamic deficit may be produced in the territory of the same.(ABSTRACT TRUNCATED AT 250 WORDS)

  19. Spontaneous carotid artery dissection causing a juvenile cerebral infarction

    Energy Technology Data Exchange (ETDEWEB)

    Trattnig, S.; Huebsch, P.; Schindler, E.

    1988-11-01

    The case of a 19-year-old patient is presented who was admitted with aphasia and hemiparesis due to basal ganglia infarction as a result of spontaneous dissection of the internal carotid artery. The difficulties in diagnosing this disease with CT and MRI in the acute stage are demonstrated. Angiography is still imperative in order to ascertain that a carotid dissection has occurred.

  20. Observation on the efficacy of acupuncture at key acupoints combined with rehabilitation therapy for spasmodic hemiplegia after cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    佟帅

    2013-01-01

    Objective To assess the clinical efficacy of acupuncture at key acupoints combined with the routine rehabilitation training of limb function on spasmodic hemiplegia after cerebral infarction.Methods Eighty-six cases were randomized into an acupuncture combined with

  1. Acute myocardial/cerebral infarction as first/relapse manifestation in one acute promyelocytic leukemia patient.

    Science.gov (United States)

    Li, Ying; Suo, Shanshan; Mao, Liping; Wang, Lei; Yang, Chunmei; Xu, Weilai; Lou, Yinjun; Mai, Wenyuan

    2015-01-01

    In the clinical setting, bleeding is a common manifestation of acute promyelocytic leukemia (APL), whereas thrombosis is relatively rare, especially as an initial symptom. Here, we report an unusual case of APL with acute myocardial infarction as the first manifestation and cerebral infarction as the relapse manifestation in a healthy young woman. This unique case emphasizes that a thrombotic event could be the first manifestation of an underlying hematological disorder such as APL and could also be a sign of relapse. Rapid detection of the underlying disorder and the timely use of anticoagulation therapy and ATRA are crucial for preventing further deterioration of the disease and saving the patient's life.

  2. Cerebral infarction presenting pure motor mono-paresis. Diagnosis by diffusion-weighted MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Oda, Masaya; Udaka, Fukashi; Nishinaka, Kazuto; Kubori, Tamotsu; Kameyama, Masakuni [Sumitomo Hospital, Osaka (Japan)

    2001-02-01

    We studied 10 patients with acute ischemic cerebrovascular disorders presenting paralysis confined to one limb, unaccompanied by sensory signs (pure motor monoparesis, PMM) on diffusion-weighted MR imaging (DWI). DWI revealed fresh ischemic lesions in all patients, except for 2 cases of transient ischemic attack. On DWI, acute infarction in multiple lesions was identified, and small superficial lesions were clearly described. Superficial lesions were seen in 4 patients, and deep lesions were also seen in 4 patients. DWI is useful for lesion analysis in cerebral infarction with PMM. (author)

  3. Correlation between synaptic plasticity, associated proteins, and rehabilitation training in a rat model of cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Dan Yang; Qian Yu

    2008-01-01

    All motions provide sensory, motoric, and reflexive input to the central nervous system, as well as playing an important role in cerebral functional plasticity and compensation. Cerebral plasticity has become the theoretical basis of neurorehabilitation. Studies of cerebrovascular disease, in particular, demonstrate that regeneration is accompanied by multiple forms of plasticity, such as functional and structural, in different phases of stroke rehabilitation. This study was designed to measure synaptic plasticity and expression of associated proteins to analyze the effect of rehabilitation training on learning and memory in a rat model of cerebral infarction. Results suggest that rehabilitation training increases expression of nerve growth factor associated protein 43, brain-derived neurotrophic factor, and neural cell adhesion molecules, and also promotes cerebral functional plasticity.

  4. Neuroprotective effect of butylphthalide combined with aspirin and clopidogrel antiplatelet therapy on progressive cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Xing-Bing He

    2016-01-01

    Objective:To analyze the neuroprotective effect of butylphthalide combined with aspirin and clopidogrel antiplatelet therapy on progressive cerebral infarction.Methods:A total of 86 patients with progressive cerebral infarction were randomly divided into observation group and control group (n=43), control group received aspirin and clopidogrel antiplatelet therapy, observation group received butylphthalide combined with aspirin and clopidogrel antiplatelet therapy, and then the differences in platelet function, blood coagulation function, middle cerebral artery blood flow state and nerve function index levels were compared between two groups after treatment.Results: After 1 course of treatment, the relative content of P-selectin and GPIIb/IIIa on platelet surface as well as TXB2, vWF and D-D content in plasma of observation group were significantly lower than those of control group, while 6-Keto-PGF1 content in plasma was significantly higher than that of control group); thrombelastogram indexes R and K value were higher than those of control group while MA, Angle and CI value were lower than those of control group; middle cerebral artery PSV, EDV, Vm and PI were higher than those of control group while RI value was lower than that of control group; nerve function indexes BDNF and H2S content in plasma were higher than those of control group while NSE, MBP, S100B and MMP-9 content were lower than those of control group (P<0.05). Conclusions:Butylphthalide combined with aspirin and clopidogrel antiplatelet therapy can effectively optimize the platelet and blood coagulation function in patients with progressive cerebral infarction, promote the middle cerebral artery blood flow recovery and exert positive neuroprotective effect.

  5. Cranial computerized tomography and cerebral angiography in diagnosis of infarction

    Energy Technology Data Exchange (ETDEWEB)

    Zuelich, K.J.

    1988-08-05

    Discussion of the radiological means to further analysis of the pathogenesis of cerebrovascular alterations up to real stroke with infarction. Today in the first place computer-tomography even with contrast means, moreover in the form of 'angio-CT' are used. Localization, size, form, and the grade of tissue destruction may be analyzed. Furthermore perifocal edema and the stage as also the effect of vascular anastomoses for a collateral circulation may be evaluated. Invasive angiography with puncture of carotid and vertebral arteries is used only in special rare indications. Instead, digital computerized angiography (DSA) can be adopted if particular interest is in the study of intracranial arteries, even with an 'invasive' approach, e.g. by femoral catheter (Seldinger). In summarizing: For the analysis of particular problems radiological methods may assist diagnosis and therapy of cerebrovascular infarct.

  6. Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in early focal cerebral infarction following urokinase thrombolysis in rats

    Institute of Scientific and Technical Information of China (English)

    Yuqiang Song; Hongli Zou; Guofeng Wang; Hongxia Yang; Zhaohong Xie; Jianzhong Bi

    2012-01-01

    Activity of matrix metalloproteinase-9 increases following cerebral ischemia/reperfusion, and is associated with cerebral microvascular permeability, blood-brain barrier destruction, inflammatory cell infiltration and brain edema. Matrix metalloproteinase-9 also likely participates in thrombolysis. A rat model of middle cerebral artery infarction was established by injecting autologous blood clots into the internal carotid artery. At 3 hours following model induction, urokinase was injected into the caudal vein. Decreased neurological severity score, reduced infarct volume, and increased expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 were observed in the cerebral cortex 24 hours after urokinase thrombolysis. These results suggest that urokinase can suppress damage in the acute-early stage of cerebral infarction.

  7. A Case of Skull Base Osteomyelitis with Multiple Cerebral Infarction

    Directory of Open Access Journals (Sweden)

    Haruka Miyabe

    2016-01-01

    Full Text Available Skull base osteomyelitis is classically documented as an extension of malignant otitis externa. Initial presentation commonly includes aural symptoms and cranial nerve dysfunctions. Here we present a case that emerged with multiple infarctions in the right cerebrum. A male in his 70s with diabetes mellitus and chronic renal failure presented with left hemiparesis. Imaging studies showed that blood flow in the carotid artery remained at the day of onset but was totally occluded 7 days later. However, collateral blood supply prevented severe infarction. These findings suggest that artery-to-artery embolization from the petrous and/or cavernous portion of the carotid artery caused the multiple infarctions observed on initial presentation. Osteomyelitis of the central skull base was diagnosed on the basis of the following findings taken together: laboratory results showing high levels of inflammation, presence of Pseudomonas aeruginosa in the otorrhea and blood culture, multiple cranial nerve palsies that appeared later, the bony erosion observed on CT, and the mass lesion on MRI. Osteomyelitis was treated successfully by long-term antibiotic therapy; however, the patient experienced cefepime-induced neurotoxicity during therapy. The potential involvement of the internal carotid artery in this rare and life-threatening disease is of particular interest in this case.

  8. Is decompressive craniectomy for malignant middle cerebral artery infarction of any worth?

    Institute of Scientific and Technical Information of China (English)

    YANG Xiao-feng; YAO Yu; HU Wei-wei; LI Gu; XU Jin-fang; ZHAO Xue-qun; LIU Wei-guo

    2005-01-01

    Objective: Malignant middle cerebral artery (MCA) infarction is characterized by mortality rate of up to 80%. The aim of this study was to determine the value of decompressive craniectomy in patients presenting malignant MCA infarction compared with those receiving medical treatment alone. Methods: Patients with malignant MCA infarction treated in our hospital between January 1996 and March 2004 were included in this retrospective analysis. The National Institute of Health Stroke Scale (NIHSS)was used to assess neurological status on admission and at one week after surgery. All patients were followed up for assessment of functional outcome by the Barthel index (BI) and modified Rankin Scale (RS) at 3 months after infarction. Results: Ten out of 24patients underwent decompressive craniectomy. The mean interval between stroke onset and surgery was 62.10 h. The mortality was 10.0% compared with 64.2% in patients who received medical treatment alone (P<0.001). The mean NIHSS score before surgery was 26.0 and 15.4 after surgery (P<0.001). At follow up, patients who underwent surgery had significantly better outcome with mean BI of 53.3, RS of 3.3 as compared to only 16.0 and 4.60 in medically treated patients. Speech function also improved in patients with dominant hemispherical infarction. Conclusion: Decompressive craniectomy in patients with malignant MCA infarction improves both survival rates and functional outcomes compared with medical treatment alone. A randomized controlled trial is required to substantiate those findings.

  9. Ipsilateral mamillary body atrophy after infarction of the posterior cerebral artery territory: MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Uchino, Akira; Sawada, Akihiro; Takase, Yukinori; Nomiyama, Keita; Egashira, Ryoko; Kudo, Sho [Saga Medical School, Department of Radiology, Saga (Japan)

    2005-11-01

    We describe herein magnetic resonance (MR) features of ipsilateral mamillary body atrophy after infarction of the posterior cerebral artery (PCA) territory. During the period May 2000 through July 2004, 13 patients with infarction of the PCA territory underwent cranial MR imaging in the chronic stage. Two 1.5-T scanners were used to obtain axial T1- and T2-weighted images with conventional spin-echo and fast spin-echo pulse sequences, respectively. The slice thickness was 6 mm, with a 2-mm interslice gap. Five of the 13 patients with PCA territory infarction had ipsilateral mamillary body atrophy. However, this asymmetry of the mamillary bodies was unclear in two of the five patients because of the thickness of the axial image slices. All five patients had a temporo-parieto-occipital infarction. The remaining eight patients had a parieto-occipital or an occipital infarction. Unilateral transneuronal mamillary body degeneration after infarction of the ipsilateral PCA territory including the posteromedial temporal lobe can be detected on conventional thick axial MR images. (orig.)

  10. Decreased cerebral glucose metabolism associated with mental deterioration in multi-infarct dementia

    Energy Technology Data Exchange (ETDEWEB)

    Meguro, K. (Tohoku Univ. School of Medicine (Japan). Dept. of Geriatric Medicine Miyama Hospital (Japan)); Doi, C. (Tohoku Univ. School of Literature (Japan). Dept. of Psychology); Yamaguchi, T.; Sasaki, H. (Tohoku Univ. School of Medicine (Japan). Dept. of Geriatric Medicine); Matsui, H.; Yamada, K. (Tohoku Univ. (Japan). Research Inst. for Tuberculosis and Cancer); Kinomura, S. (Miyama Hospital (Japan) Tohoku Univ. (Japan). Research Inst. for Tuberculosis and Cancer); Itoh, M. (Tohoku Univ. School of Medicine (Japan). Cyclotron Radioisotope Center)

    1991-08-01

    Cerebral glucose metabolism of 18 patients with multi-infarct dementia (MID) and 10 age-matched normal subjects were examined with positron emission tomography and the {sup 18}-F-fluoro-deoxy-glucose technique. MID patients had significantly lower glucose metabolsim in all the grey matter regions measured and were also characterized by more individuality in metabolic pattern. MID patients were also evaluated as to intelligence quotient (IQ). A positive correlation between IQ as shown by the Tanaka-Binet test and glucose metabolism for the entire grey matter was found. The clinical applicability of this test for predicting cerebral metabolism is discussed. (orig.).

  11. [Therapeutic potential of bone marrow stem cells in cerebral infarction].

    Science.gov (United States)

    Sánchez-Cruz, Gilberto; Milián-Rodríguez, Lismary

    2015-05-16

    Introduccion. Las celulas madre constituyen una alternativa terapeutica que se encuentra en fase de experimentacion para el infarto cerebral. Objetivo. Mostrar la evidencia cientifica existente sobre el potencial terapeutico de las celulas madre de la medula osea en esta enfermedad. Desarrollo. El infarto cerebral representa el 80% de las enfermedades cerebrovasculares. La trombolisis constituye la unica terapia aprobada, pero, por su estrecha ventana terapeutica, solo se aplica a un bajo porcentaje de los pacientes. De manera alternativa, los tratamientos neurorrestauradores, como el de celulas madre, pueden aplicarse en periodos mas prolongados. Por esta razon se efectuo una busqueda bibliografica en PubMed con el empleo de las palabras clave 'stem cells', 'bone marrow derived mononuclear cells' y 'stroke'. Se encontraron evidencias de seguridad y eficacia de dichas celulas en diferentes momentos evolutivos del infarto cerebral. Se identificaron estudios que en clinica y preclinica las recolectaron por puncion medular y en sangre periferica, y las trasplantaron directamente en el area infartada o por via intravascular. El efecto terapeutico se relaciona con sus propiedades de plasticidad celular y liberacion de factores troficos. Conclusiones. El concentrado de celulas mononucleares autologas, obtenido en sangre periferica o por puncion de la medula osea, y trasplantado por via intravenosa, es una factible opcion metodologica que permitira rapidamente incrementar el numero de ensayos clinicos en diferentes etapas evolutivas del infarto cerebral. Esta terapia muestra seguridad y eficacia; sin embargo, deben ampliarse las evidencias que avalen su generalizacion en humanos.

  12. Orthogonal design to sift the optimal parameter of Neiguan acupuncture for cerebral infarction.

    Science.gov (United States)

    Zhang, Yanan; Yang, Sha; Fan, Xiaonong; Wang, Shu; He, Nina; Li, Lingxin; Luo, Ding; Shi, Xuemin

    2013-10-05

    The individual difference and non-repeatability in acupuncture have not only restricted the development of acupuncture, but have also affected the specificity of acupoints. The present study used instruments to control needle depth, lifting and thrusting frequency, and the duration of acupuncture. Effects of the quantified acupuncture were observed at Neiguan (PC6) with different stimulation parameters. A frequency of 1, 2, or 3 Hz and duration of 5, 60, or 180 seconds were used to observe cerebral blood flow and ratio of infarct volume recovery. Results showed that stimulation at Neiguan with a frequency of 1 Hz and long duration of 180 seconds or 2/3 Hz and long duration of 5/60 seconds significantly increased cerebral blood flow and decreased the ratio of infarct volume. Interactions between frequency and duration play a critical role in quantified acupuncture therapy.

  13. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy in a Chinese pedigree

    Institute of Scientific and Technical Information of China (English)

    Erhe Xu; Huiqing Dong; Milan Zhang; Min Xu

    2012-01-01

    The present study enrolled a Chinese family that comprised 34 members and spanned three generations. Eight members were diagnosed with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, and disease diagnoses corresponded with autosomal incomplete dominance inheritance. The primary clinical manifestations included paralysis, dysarthria, and mild cognitive deficits. Magnetic resonance imaging revealed diffuse leukoencephalopathy with involvement of bilateral anterior temporal lobes, in particular the pons. In addition, multiple cerebral infarction was identified in the proband. Sural nerve biopsy findings of the proband revealed granular osmophilic material deposits in the extracellular matrix, which were adjacent to smooth muscle cells of dermal arterioles. Screening exons 2-4 for NOTCH 3 mutations by direct sequencing did not reveal any abnormalities.

  14. [Perioperative treatment of a pregnant woman with recent cerebral infarction secondary to noncompaction cardiomyopathy].

    Science.gov (United States)

    Fernández Sánchez, L J; Pérez González, R; Guasch Arévalo, E; Martín Reyes, R; Gilsanz Rodríguez, F

    2006-12-01

    Recent-onset noncompaction of the myocardium is a rare but serious entity with uncertain prognosis. Cerebral infarction is among the forms of presentation, and pregnancy and hypercoagulability increase risk. We report the case of a pregnant woman brought to the emergency department with ischemic cerebral infarction. Investigation demonstrated the cause to be cardiac embolism, and noncompaction of the myocardium was diagnosed. She was stabilized and a few days later underwent elective cesarean section under general anesthesia. Surgery and postoperative recovery were uneventful, and she was transferred for rehabilitation. Myocardial injury and progression to cerebrovascular accident must be prevented in such cases; the patient must be stabilized and antiplatelet and/or anticoagulant therapy initiated before surgery. Hemodynamic stability must be maintained throughout the perioperative period and neonatal depression avoided after delivery. Various approaches are available to be adapted to the patient's situation.

  15. Malignant infarction of the middle cerebral artery in a porcine model. A pilot study

    Science.gov (United States)

    Martínez-Valverde, Tamara; Sánchez-Guerrero, Ángela; Campos, Mireia; Esteves, Marielle; Gandara, Dario; Torné, Ramon; Castro, Lidia; Dalmau, Antoni; Tibau, Joan

    2017-01-01

    Background and purpose Interspecies variability and poor clinical translation from rodent studies indicate that large gyrencephalic animal stroke models are urgently needed. We present a proof-of-principle study describing an alternative animal model of malignant infarction of the middle cerebral artery (MCA) in the common pig and illustrate some of its potential applications. We report on metabolic patterns, ionic profile, brain partial pressure of oxygen (PtiO2), expression of sulfonylurea receptor 1 (SUR1), and the transient receptor potential melastatin 4 (TRPM4). Methods A 5-hour ischemic infarct of the MCA territory was performed in 5 2.5-to-3-month-old female hybrid pigs (Large White x Landrace) using a frontotemporal approach. The core and penumbra areas were intraoperatively monitored to determine the metabolic and ionic profiles. To determine the infarct volume, 2,3,5-triphenyltetrazolium chloride staining and immunohistochemistry analysis was performed to determine SUR1 and TRPM4 expression. Results PtiO2 monitoring showed an abrupt reduction in values close to 0 mmHg after MCA occlusion in the core area. Hourly cerebral microdialysis showed that the infarcted tissue was characterized by reduced concentrations of glucose (0.03 mM) and pyruvate (0.003 mM) and increases in lactate levels (8.87mM), lactate-pyruvate ratio (4202), glycerol levels (588 μM), and potassium concentration (27.9 mmol/L). Immunohistochemical analysis showed increased expression of SUR1-TRPM4 channels. Conclusions The aim of the present proof-of-principle study was to document the feasibility of a large animal model of malignant MCA infarction by performing transcranial occlusion of the MCA in the common pig, as an alternative to lisencephalic animals. This model may be useful for detailed studies of cerebral ischemia mechanisms and the development of neuroprotective strategies. PMID:28235044

  16. MR image features predicting hemorrhagic transformation in acute cerebral infarction: a multimodal study

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Chunming; Xu, Liang; Dong, Longchun; Liu, Zhenxing; Yang, Jun; Liu, Jun [Tianjin Union Medicine Centre, Department of Radiology, Tianjin (China); Dong, Zhengchao [Columbia University, Translational Imaging and MRI Unit, Department of Psychiatry, New York, NY (United States); New York State Psychiatric Institute, New York, NY (United States); Khursheed, Aiman [Tianjin Medical University, International Medical School, Tianjin (China)

    2015-11-15

    The aims of this study were to observe magnetic resonance imaging (MRI) features and the frequency of hemorrhagic transformation (HT) in patients with acute cerebral infarction and to identify the risk factors of HT. We first performed multimodal MRI (anatomical, diffusion weighted, and susceptibility weighted) scans on 87 patients with acute cerebral infarction within 24 hours after symptom onset and documented the image findings. We then performed follow-up examinations 3 days to 2 weeks after the onset or whenever the conditions of the patients worsened within 3 days. We utilized univariate statistics to identify the correlations between HT and image features and used multivariate logistical regression to correct for confounding factors to determine relevant independent image features of HT. HT was observed in 17 out of total 87 patients (19.5 %). The infarct size (p = 0.021), cerebral microbleeds (CMBs) (p = 0.004), relative apparent diffusion (rADC) (p = 0.023), and venous anomalies (p = 0.000) were significantly related with HT in the univariate statistics. Multivariate analysis demonstrated that CMBs (odd ratio (OR) = 0.082; 95 % confidence interval (CI) = 0.011-0.597; p = 0.014), rADC (OR = 0.000; 95 % CI = 0.000-0.692; p = 0.041), and venous anomalies (OR = 0.066; 95 % CI = 0.011-0.403; p = 0.003) were independent risk factors for HT. The frequency of HT is 19.5 % in this study. CMBs, rADC, and venous anomalies are independent risk factors for HT of acute cerebral infarction. (orig.)

  17. Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome.

    Science.gov (United States)

    Yamada, Yoshiji; Kato, Kimihiko; Oguri, Mitsutoshi; Yoshida, Tetsuro; Yokoi, Kiyoshi; Watanabe, Sachiro; Metoki, Norifumi; Yoshida, Hidemi; Satoh, Kei; Ichihara, Sahoko; Aoyagi, Yukitoshi; Yasunaga, Akitomo; Park, Hyuntae; Tanaka, Masashi; Nozawa, Yoshinori

    2008-06-01

    Metabolic syndrome is a risk factor for cardiovascular disease. The aim of the present study was to identify genetic variants that confer susceptibility to atherothrombotic cerebral infarction among individuals with metabolic syndrome in order to allow prediction of genetic risk for this condition. The study population comprised 1284 unrelated Japanese individuals with metabolic syndrome, including 313 subjects with atherothrombotic cerebral infarction and 971 controls. The genotypes for 296 polymorphisms of 202 candidate genes were determined with a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. The Chi-square test, multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of hypertension, hypercholesterolemia, and diabetes mellitus, as well as a stepwise forward selection procedure revealed that the 2445G-->A (Ala54Thr) polymorphism (rs1799883) of FABP2, the -108/3G-->4G polymorphism of IPF1 (S82168), the A-->G (Thr94Ala) polymorphism (rs2241883) of FABP1, the G-->A (Asp2213Asn) polymorphism (rs529038) of ROS1, the -11377C-->G polymorphism (rs266729) of ADIPOQ, the 162A-->C polymorphism (rs4769055) of ALOX5AP, the -786T-->C polymorphism (rs2070744) of NOS3, and the 3279C-->T polymorphism (rs7291467) of LGALS2 were associated (PA (Ala54Thr) polymorphism of FABP2 was most significantly associated with this condition. Our results suggest that FABP2, IPF1, FABP1, ROS1, ADIPOQ, ALOX5AP, NOS3, and LGALS2 are susceptibility loci for atherothrombotic cerebral infarction among Japanese individuals with metabolic syndrome. Genotypes for these polymorphisms, especially for the 2445G-->A (Ala54Thr) polymorphism of FABP2, may prove informative for the prediction of genetic risk for atherothrombotic cerebral infarction among such individuals.

  18. Effect of Transcranial Magnetic Stimulation on the Expression of c-Fos and Brain-derived Neurotrophic Factor of the Cerebral Cortex in Rats with Cerebral Infarct

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xiaoqiao; MEI Yuanwu; LIU Chuanyu; YU Shanchun

    2007-01-01

    The effect of transcranial magnetic stimulation (TMS) on the neurological functional recovery and expression of c-Fos and brain-derived neurotrophic factor (BDNF) of the cerebral cortex in rats with cerebral infarction was investigated. Cerebral infarction models were established by using left middle cerebral artery occlusion (MCAO) and were randomly divided into a model group (n=40) and a TMS group (n=40). TMS treatment (2 times per day, 30 pulses per time) with a frequency of 0.5 Hz and magnetic field intensity of 1.33 Tesla was carried out in TMS group after MCAO. Modified neurological severity score (NSS) were recorded before and 1, 7, 14, 21, and 28 day(s) after MCAO. The expression of c-Fos and BDNF was immunohistochemically detected 1, 7,14, 21, and 28 day(s) after infarction respectively. Our results showed that a significant recovery of NSS (P<0.05) was found in animals treated by TMS on day 7, 14, 21, and 28 as compared with the animals in the model group. The positive expression of c-Fos and BDNF was detected in the cortex surrounding the infarction areas, while the expression of c-Fos and BDNF increased significantly in TMS treatment group in comparison with those in model group 7, 14, 21, and 28 days (P<0.05) and 7,14, 21 days (P<0.01) after infarction, respectively. It is concluded that TMS has therapeutic effect on cerebral infarction and this may have something to do with TMS's ability to promote the expression of c-Fos and BDNF of the cerebral cortex in rats with cerebral infarction.

  19. Liposome-encapsulated hemoglobin reduces the size of cerebral infarction in rats: effect of oxygen affinity.

    Science.gov (United States)

    Fukumoto, Dai; Kawaguchi, Akira T; Haida, Munetaka; Yamano, Mariko; Ogata, Yoshitaka; Tsukada, Hideo

    2009-02-01

    Liposome-encapsulated hemoglobin (LEH) with a low oxygen affinity (l-LEH, P(50) = 45 mm Hg) was found to be protective in the rodent and primate models of ischemic stroke. This study investigated the role of LEH with a high O(2) affinity (h-LEH, P(50) = 10 mm Hg) in its protective effect on brain ischemia. The extent of cerebral infarction was determined 24 h after photochemically induced thrombosis of the middle cerebral artery from the integrated area of infarction detected by triphenyltetrazolium chloride staining in rats receiving various doses of h-LEH as well as l-LEH. Both h-LEH and l-LEH significantly reduced the extent of cortical infarction. h-LEH remained protective at a lower concentration (minimal effective dose [MED]: 0.08 mL/kg) than l-LEH (MED: 2 mL/kg) in the cortex. h-LEH reduced the infarction extent in basal ganglia as well (MED: 0.4 mL/kg), whereas l-LEH provided no significant protection. h-LEH provided better protection than l-LEH. The protective effect of both high- and low-affinity LEH may suggest the importance of its small particle size (230 nm) as compared to red blood cells. The superiority of h-LEH over l-LEH supports an optimal O(2) delivery to the ischemic penumbra as the mechanism of action in protecting against brain ischemia and reperfusion.

  20. S-nitrosylated pegylated hemoglobin reduces the size of cerebral infarction in rats.

    Science.gov (United States)

    Kawaguchi, Akira T; Nakai, Kunihiko; Fukumoto, Dai; Yamano, Mariko; Haida, Munetaka; Tsukada, Hideo

    2009-02-01

    Cell-free hemoglobin-based oxygen carriers have well-documented safety and efficacy problems such as nitric oxide (NO) scavenging and extravasation that preclude clinical use. To counteract these effects, we developed S-nitrosylated pegylated hemoglobin (SNO-PEG-Hb, P(50) = 12 mm Hg) and tested it in a brain ischemia and reperfusion model. Neurological function and extent of cerebral infarction was determined 24 h after photochemically induced thrombosis of the middle cerebral artery in the rat. Infarction extent was determined from the integrated area in the cortex and basal ganglia detected by triphenyltetrazolium chloride staining in rats receiving various doses of SNO-PEG-Hb (2, 0.4, and 0.08 mL/kg) and compared with rats receiving pegylated hemoglobin without S-nitrosylation (PEG-Hb) or saline of the same dosage. Results indicated that successive dilution revealed SNO-PEG-Hb but not PEG-Hb to be effective in reducing the size of cortical infarction but not neurological function at a dose of 0.4 mL/kg. In conclusion, SNO-PEG-Hb in a dose of 0.4 mL/kg (Hb 24 mg/kg) showed to be most effective in reducing the size of cortical infarction, however, without functional improvement.

  1. Motor outcomes of patients with a complete middle cerebral artery territory infarct*

    Institute of Scientific and Technical Information of China (English)

    Sung Ho Jang; Min Cheol Chang

    2013-01-01

    Detailed knowledge of motor outcomes enables to establish proper goals and rehabilitation strate-gies for stroke patients. Several previous studies have reported functional or motor outcomes in patients with a middle cerebral artery territory infarct. However, little is known about motor outcome in patients with a complete middle cerebral artery territory infarct. In this study, we investigated the motor outcomes in 23 patients with a complete middle cerebral artery territory infarct. Al of these patients received comprehensive rehabilitative management, including movement therapy and neuromuscular electrical stimulation of the affected finger extensors and ankle dorsiflexors, for more than 3 months. Motor outcomes were measured at 6 months after stroke onset using the Medical Research Council, Motricity Index, the modified Brunnstrom Classification, and Functional Ambula-tion Category scores. The motor function of the lower extremities was found to be better than that of the upper extremities. After receiving rehabilitation treatments for 3-6 months, about 70%of these patients were able to walk independently (Functional Ambulation Category scores>3), but no pa-tient achieved functional hand recovery.

  2. Effect of alprostadil combined with conventional therapy on serum markers in patients with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Li-Lan Chen; Guo-Qiang Chen; Tao Yang; Mu-Qing Long

    2016-01-01

    Objective:To study the effect of alprostadil combined with conventional therapy on serum markers in patients with acute cerebral infarction.Methods:Patients with acute cerebral infarction treated in our hospital from May 2012 to August 2014 were enrolled and randomly divided into two groups. Observation group received alprostadil combined with conventional therapy and control group received conventional treatment. Then serum markers of both groups were compared.Results:(1) contents of serum nerve function related molecules: serum NSE and S100βcontents of observation group showed a decreasing trend, and BDNF and NGF contents showed an increasing trend; (2) contents of atherosclerosis related enzymes: serum GGT, iNOS and MPO contents of observation group showed a decreasing trend, and PON1 and PON2 contents showed an increasing trend; (3) platelet activation related molecules: serum PPARγ, CD62p, YKL-40, sCD40L and Fibulin-5 contents of observation group all showed a decreasing trend.Conclusions:Alprostadil combined with conventional treatment is helpful to alleviate neuronal damage and inhibit the processes of atherosclerosis and platelet activation;it’s an ideal method for treating acute cerebral infarction.

  3. Polymorphism of Apolipoprotein A5 is a Risk Factor for Cerebral Infarction in Type 2 Diabetes

    Institute of Scientific and Technical Information of China (English)

    Xuefeng LI; Yancheng XU; Yan DING; Chengming QIN; Zhe DAI; Li NIU

    2008-01-01

    This study investigated the association of apolipoprotein A5 (apoAS) gene polymorphism at position -113 ITC with cerebral infarction in patients with type 2 diabetes. A total of 256 type 2 diabetic patients without cerebral infarction (T2DM), 220 type 2 diabetic patients with cerebral infarction (T2DMCI) and 340 healthy subjects were recruited from the same region (Hubei province,China). The genotype of apoA5 -1131TC was analyzed by polymerase chain reaction, followed by restriction fragment length polymorphism (PCR-RFLP). Total cholesterol, HDL cholesterol,LDL-cholesterol and trigiycerides were quantitatively detected by using standard enzymatic techniques. The results showed that the prevalence of the apoA5 -1131C allele was significantly higher in T2DMCI group than that in control group (42.7% versus 31.2%, P<0.01). The carriers of rare C allele had higher TG levels as compared with carders of common allele in the three groups (P<0.01). Logistic regression models, which were adjusted for age, gender, blood pressure, BMI, FBS, smoking,LDL-C and HDL-C, revealed that patients carrying the apoA5 -1131C allele and CC homozygotes were at high risk for T2DMCI. It was concluded that the apoA5 -ll31C allele variant is an independent genetic risk factor for T2DMCI.

  4. Cerebral Infarct due to Fibromuscular Dysplasia: A Case Report

    Directory of Open Access Journals (Sweden)

    Arzu Tay

    2013-04-01

    Full Text Available The course of cervicocephalic fibromuscular dysplasia is mainly asymptomatic. It is often found as an incidental finding on autopsy or angiography mostly in women and is commonly located in extracranial region of carotid artery. In the present article, we reported a 21 year-old man who has been initially accepted to our intensive care with a tentative diagnosis of cerebrovascular infarct after having symptoms of loss of consciousness and right hemiparesis. He later received a certain diagnosis of fibromuscular dysplasia after neuroimaging findings. This disorder should be considered in differential diagnosis of young stroke patients. [Cukurova Med J 2013; 38(2.000: 305-307

  5. Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia.

    Science.gov (United States)

    Yao, Xiaoming; Derugin, Nikita; Manley, Geoffrey T; Verkman, A S

    2015-01-01

    Aquaporin-4 (AQP4) is a water channel expressed in astrocyte end-feet lining the blood-brain barrier. AQP4 deletion in mice is associated with improved outcomes in global cerebral ischemia produced by transient carotid artery occlusion, and focal cerebral ischemia produced by permanent middle cerebral artery occlusion (MCAO). Here, we investigated the consequences of 1-h transient MCAO produced by intraluminal suture blockade followed by 23 h of reperfusion. In nine AQP4(+/+) and nine AQP4(-/-) mice, infarct volume was significantly reduced by an average of 39 ± 4% at 24h in AQP4(-/-) mice, cerebral hemispheric edema was reduced by 23 ± 3%, and Evans Blue extravasation was reduced by 31 ± 2% (mean ± SEM). Diffusion-weighted magnetic resonance imaging showed greatest reduction in apparent diffusion coefficient around the occlusion site after reperfusion, with remarkably lesser reduction in AQP4(-/-) mice. The reduced infarct volume in AQP4(-/-) mice following transient MCAO supports the potential utility of therapeutic AQP4 inhibition in stroke.

  6. Cerebral infarction in an HIV-infected patient with combined protein S and C deficiency and a patent foramen ovale.

    Science.gov (United States)

    Tomomasa, Ran; Yamashiro, Kazuo; Tanaka, Ryota; Hattori, Nobutaka

    2013-11-01

    A 41-year-old male with a history of human immunodeficiency virus (HIV) infection developed motor aphasia, dysarthria, and right hemiparesis. A magnetic resonance imaging scan of the brain revealed a cerebral infarction in the territory of the left middle cerebral artery. The laboratory data showed decreased levels of protein S and protein C. Transesophageal contrast-enhanced echocardiography revealed a patent foramen ovale (PFO). Prothrombotic states, such as protein S and C deficiency, have been reported in HIV-infected patients. In addition, previous studies have reported prothrombotic states to be risk factors for PFO-related cerebral infarction. An association between combined protein S and C deficiency caused by HIV infection and PFO-related cerebral infarction was suggested in our patient.

  7. Xueshuantong improves cerebral blood perfusion in elderly patients with lacunar infarction

    Institute of Scientific and Technical Information of China (English)

    Qifeng Gui; Yunmei Yang; Shihong Ying; Minming Zhang

    2013-01-01

    A total of 64 patients with acute lacunar infarction were enrolled within 24 hours of onset. The patients received conventional therapy (antiplatelet drugs and hypolipidemic drugs) alone or conventional therapy plus 450 mg Xueshuantong once a day. The main ingredient of the Xueshuantong lyophilized powder used for injection was Panax notoginseng saponins. Assessments were made at admission and at discharge using the National Institutes of Health Stroke Scale, the Activity of Daily Living and the Mini-Mental State Examination. Additionally, the relative cerebral blood flow, relative cerebral blood volume and relative mean transit time in the region of interest were calculated within 24 hours after the onset of lacunar infarction, using dynamic susceptibility contrast magnetic resonance perfusion imaging technology. Patients underwent a follow-up MRI scan after 4 weeks of treatment. There was an improvement in the Activity of Daily Living scores and a greater reduction in the scores on the National Institutes of Health Stroke Scale in the treatment group than in the control group. However, the Mini-Mental State Examination scores showed no significant differences after 4 weeks of treatment. Compared with the control group, the relative cerebral blood flow at discharge had increased and showed a greater improvement in the treatment group. Furthermore, there was a reduction in the relative mean transit time at discharge and the value was lower in the treatment group than in the control group. The experimental findings indicate that Xueshuantong treatment improves neurological deficits in elderly patients with lacunar infarction, and the mechanism may be related to increased cerebral perfusion.

  8. Influence of rotating magnetic field on cerebral infarction volume, cerebral edema and free radicals metabolism after cerebral ischemia/reperfusion injury in rats

    Institute of Scientific and Technical Information of China (English)

    Xiaohong Liu; Zhiqiang Zhang; Lixin Zhang

    2006-01-01

    BACKGROUND: It has shown that magnetic field can improve blood circulation, decrease blood viscosity, inhibit free radicals, affect Ca2+ flow in nerve cells, control inflammatory and immunological reaction, and accelerate nerve cell regeneration. In addition, protective effect of magnetic field, which acts as an iatrophysics, on ischemic brain tissues has been understood gradually.OBJECTIVE: To investigate the effects of rotating magnetic field (RMF) on volume of cerebral infarction,cerebral edema and metabolism of free radicals in rats after cerebral ischemia/reperfusion injury.DESIGN: Randomized controlled animal study.SETTING: Rehabilitation Center of disabled children, Liaoniang; Department of Rehabilitation, the Second Affiliated Hospital, China Medical University; Department of Rehabilitation Physiotherapy, the First Affiliated Hospital, China Medical University.MATERIALS: A total of 70 healthy Wistar rats aged 18-20 weeks of both genders were selected and randomly divided into 3 groups: sham operation group with 12 rats, control group with 20 rats and treatment group with 38 rats. The treatment group included 4 time points: immediate reperfusion with 6 ones, 6-hour reperfusion with 20 ones, 12-hour reperfusion with 6 ones and 18-hour reperfusion with 6 rats. Main instruments were detailed as follows: magnetic head of rotating magnetic device was 6 cm in diameter; magnetic induction intensity at the surface of magnetic head was 0.25 T in silence; the maximal magnetic induction intensity was 0.09 T at the phase of rotation; the average rotating speed was 2500 r per minute.METHODS: The experiment was carried out in the China Medical University in March 2003. Focal cerebral ischemic animal models were established with modified Longa's method. Operation was the same in the sham operation, but the thread was inserted as 10 mm. Neurologic impairment was assessed with 5-rating method to screen out cases. Those survivals with grade 1 and grade 2 after ischemia for 2

  9. Alternation of plasma c-type natriuretic peptide in cerebral infarction%脑梗死患者血浆c-型利钠肽变化

    Institute of Scientific and Technical Information of China (English)

    赵文凤; 宋利春

    2003-01-01

    AIM:To investigate the effects of c type natriuretic peptide (CNP) on cerebral infarction.METHODS:Plasma levels of CNP were concomitantly measured by radioimmunoassay in 30 patients with cerebral infarction and in 30 normal controls.RESULTS:Plasma levels of CNP were increased significantly in the acute stage of cerebral infarction than those in the normal controls(P< 0.01) and levels in the moderate and serious cases were lower than those in the slight cases(P< 0.01).CONCLUSION:In cerebral infarction the increase of plasma CNP was in accordance with the severity of the disease .CNP in the pathophysiology of acute cerebral ischemia had a deleterious effect on the evolution of cerebral infarction.

  10. Combined intra-arterial thrombolysis and neuprotectant agents reduce cerebral infarction in rabbits with experimental acute cerebral ischemia

    Institute of Scientific and Technical Information of China (English)

    Pei Shi

    2006-01-01

    BACKGROUND:The intra-arterial thrombolytic therapy is one of main methods for more patients to obtain bene-fits.The percentage of arterial recanalization treated with intre-arterial therapy is higher than with intra-venous therapy.next,the dose of thrombolytic medicines is lower and the therapeutic time window may be possibly longer.Related researches are focus on intra-artedal thrombolysis combining with neuprotectant agents to treat acute ischemic stroke.The results show that combination of them can further prolong the therapeutic time window.improve the percentage of arterial recanalization and reduce cerebral infarction volume.OBJECTIVE:To observe the effect of single thmmbolitic therapy combined with neuroprotectant agents in the treatment of acute ischemic stroke.DESIGN:Randomized block design.SETTING:Xinhua Hospital of Xixiang City.Henan Province.MATERIALS:Thirty-six adult male white rabbits.weighing 1.5-2.0 kg.dean grade.were provided by Expedmental Animal Center of Xinxiang Medical College.All rabbits were randomly divided into three groups:intra-arterial thrombolysis control group.corenalin control group and combination group with 12 in each group.Urekinase was provided by Beijing Saisheng Pharmaceutical Co.,Ltd.(batch number:020923);corenalin by Sanjing Pharmaceutical Co.,Ltd.of Harbin Pharmacautical Group(batch number:021106):nimodipine by Shandong Xihua Pharmaceutical Co.,Ltd.(batch number:020611):contrast medium IOPAMlR0300 by Bracco s.P.a.Milano italian (batch number:0584);2,3,5-triphenyltetrazolium chloride(TTC)by Beijing Mashi Fine ChemicaL Product Co.,Ltd.(batch number:020926).METHODS: The experiment was camed out in the Department of Intervention. Second People's Hospital of Xinxiang from September 2002 to May 2003.①According to techniques of Benes et al and Zhu et al,animal models with acute ischemia were established.Two hours later.the therapy began.Intra-artedal thrombolysis control group:5 000 U/kg urokinase was dripped in Ieft common

  11. Edema and vascular permeability in cerebral ischemia: comparison between ischemic neuronal damage and infarction.

    Science.gov (United States)

    Petito, C K; Pulsinelli, W A; Jacobson, G; Plum, F

    1982-07-01

    The respective influences of ischemic neuronal damage and infarction on the development of abnormal blood-brain barrier (BBB) permeability and cerebral edema were evaluated in a rat model of temporary four-vessel occlusion in which ischemic neuronal damage with only infrequent infarction is produced. Survival times ranged from 40 minutes to 5 days after ischemia. Evans blue and horseradish peroxidase (HRP) were given before sacrifice. The majority of brain showed moderate ischemic neuronal damage inthe striatum. In these areas there was neither leakage of Evans blue nor extravasation of HRP. Astrocytic processes were moderately swollen. Large, grossly-visible unilateral infarcts were present in only 5 animals, and all showed abnormal BBB permeability of HRP which occurred via enchanced pinocytosis, and occasionally via diffuse leakage through necrotic vessels. Astrocytic processes were markedly swollen and their plasma membranes were disrupted. Whole brain and regional water content in a parallel series of animals were measured from 15 minutes (min) to 48 hours (h) postischemia. They showed a transient, 1% increase in whole brain water content from 15 to 60 min postischemia, but no increase in regional water content at any postischemic interval. These studies suggest that ischemia produces BBB permeability to large molecules, and sustained cerebral edema only when the process damages blood vessels and astrocytes; neuronal necrosis alone is insufficient.

  12. The Change of Mobility and Deformability of Red Cell Membrane in the Patients with Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    Wang Hongyu

    2000-01-01

    To study the blood cell hemoyheology,the mobility and deformability of red cell membrane,the activity and assembly of platelets ,the content of cholesterol crvstals and thrombus in circulation in cerebral infarction patientrs. Observing the cell hemorheologi cal condition of the red clee, platelet,cholesterol cryitals, and active thrombus in active blood analysis with Bradford's microscope(15,000 times). The study indicates that in the ceredral infarction patients,the red cell appeared rowleax and its deformbility was poor and its membrane mobility reduvde(P<0.05). In this group blood viscosity was higher, the platelet assembling rate rose and the thrombus in circulation increases more signifi cantly than the nomal group (P<0.01). The change of membrane mobility,the rsising of platelet assemble rate, the in creasing of plasma viscosity and flowing embolism are the important pathological basis of cerebral infarction. It may provide important material and practical meaning for precluding,diagnosing,curing and prognosising ischmia cerebralvas cular diseases.

  13. Medial reorganization of motor function in corona radiata following middle cerebral artery infarction A case report

    Institute of Scientific and Technical Information of China (English)

    Sung Ho Jang

    2009-01-01

    Peri-lesional reorganization is one of the motor recovery mechanisms following stroke. A 23-year-old female who presented with complete paralysis of the right extremities at the onset of infarct in the left middle cerebral artery territory was included. She slowly recovered some function, and could extend the affected knee with resistance after 9 months. Diffusion tensor tractography, functional MRI, and transcranial magnetic stimulation testing were performed at 7 years after onset. Results showed that diffusion tensor tractography of the affected (left) hemisphere passed through the medial corona radiata at, or around, the wall of the lateral ventricle. The contralateral primary sensorimotor cortex was activated during affected knee movements. The motor-evoked potential, which was obtained from the affected leg, exhibited corticospinal tract characteristics. Results indicated that motor function of the affected leg recovered via the corticospinal tract, which descended through the corona radiata medial to the infarct. The motor function of the affected leg was reorganized to the medial corona radiata following infarct to the middle cerebral artery territory.

  14. The relationship between cerebral infarction on MR and angiographic findings in moyamoya disease: significance of the posterior circulation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eun Ja; Song, Soon Young [College of Medicine, Kwangdong Univ., Koyang (Korea, Republic of); Yu, Won Jong; Jung, So Lyung; Chung, Bong Gak; Kag, Si Won [College of Medicine, The Catholic Univ. of Korea, Seoul (Korea, Republic of); Kim, Man Deuk [College of Medicine, Pochon CHA Univ., Pochon (Korea, Republic of)

    2002-06-01

    To investigate the relationship between changes in the posterior and anterior circulation, as seen at angiography, and the frequency and extent of cerebral infarction revealed by MR imaging in moyamoya disease. This study involved 34 patients (22 females and 12 males, aged 2-52 years) in whom cerebral angiography revealed the presence of moyamoya disease (bilateral; unilateral= 24:10; total hemispheres=58) and who also underwent brain MR imaging. To evaluate the angiographic findings, we applied each angiographic staging system to the anterior and posterior circulation. Leptomeningeal collateral circulation from the cortical branches of the posterior cerebral artery (PCA) was also assigned one of four grades. At MR imaging, areas of cerebral cortical or subcortical infarction in the hemisphere were divided into six zones. White matter and basal ganglionic infarction, ventricular dilatation, cortical atrophy, and hemorrhagic lesions were also evaluated. To demonstrate the statistical significance of the relationship between the angiographic and the MR findings, both the Mantel-Haenszel chi-square test for trend and the chi-square test were used. The degree of steno-occlusive PCA change correlated significantly with the internal carotid artery (ICA) stage (p<0.0001). As PCA stages advanced, the degree of leptomeningeal collaterals from the PCA decreased significantly (P<0.0001), but ICA stages were not significant (p>0.05). The prevalence of infarction showed significant correlation with the degree of steno-occlusive change in both the ICA and PCA. The degree of cerebral ischemia in moyamoya patients increased proportionally with the severity of PCA stenosis rather than with that of steno-occlusive lesins of the anterior circulation. Infarctions tended to be distributed in the anterior part of the hemisphere at PCA state I or II, while in more advanced PCA lesions, they were also found posteriorly, especially in the territories of the posterior middle cerebral artery

  15. Hyperbaric oxygen combined with drug therapy in the treatment of acute cerebral infarction clinical analysis

    Institute of Scientific and Technical Information of China (English)

    Wen-Cui Lin; Kang Lin; Jing Wang; Shuai Li

    2015-01-01

    Objective:To explore the effects of hyperbaric oxygen combined with edaravone, salviae miltiorrhizae and ligustrazine and sodium ozagrel in the treatment of acute cerebral infarction clinical analysis.Methods: A total of 200 cases of acute cerebral infraction patients were randomly divided into observation group and control group. The control group was treated with edaravone, salvia miltiorrhizae and ligustrazine and sodium ozagrel; on the basis of treatment in control group, the observation group was combined with hyperbaric oxygen therapy. The neurological deficit scores were observed before and after treatment in patients of two groups, meanwhile the activities of daily living (ADL) and clinical effects were compared.Results: The total effective rate in observation group (92%) was significantly higher than control group (79%), the differences were statistically significant; the score of ADL in observation group after treatment was obviously higher than control group [(79.91±5.16)vs (61.62±5.60)], and the differences were statistically significant. The neurological deficit scores after treatment were obviously lower than the control group [(9.55±4.13)vs (15.46±4.92)], the differences were statistically significant.Conclusion: Hyperbaric oxygen combined with edaravone, salvia miltiorrhizae and ligustrazine and sodium ozagrel in the treatment of acute cerebral infarction can improve the symptoms of microcirculation and neurologic impairment, and improve the patient s quality of life.

  16. Plasma level of neuron specific enolase in patients with acute cerebral infarction: A case-control study

    Institute of Scientific and Technical Information of China (English)

    Guoping Tian; Yang Zhang; Weiping Cheng

    2009-01-01

    BACKGROUND: The plasma level of neuron specific enolase (NSE) can be used to diagnose and evaluate neuronal injury and predict early prognosis.OBJECTIVE: To observe the dynamic changes in plasma levels of NSE in patients with acute cerebral infarction, and to investigate its correlations with disease severity and prognosis.DESIGN, TIME AND SETTING: This non-randomized, concurrent case-control experiment was performed at the Department of Neurology, First Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine between May and July 2007.PARTICIPANTS: Eighteen patients with acute cerebral infarction, who received treatment at the Department of Neurology, First Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine between May and July 2007, were recruited into the patient group. An additional 10 healthy individuals, who received health examinations simultaneously, were included as controls.METHODS: Following admission (within 3 days) and at days 6, 12, and 30 subsequent to acute cerebral infarction attack, 3 mL venous blood was taken from each patient before the morning meal to determine the plasma level of NSE by enzyme-labeled immunosorbent assay. One-time blood extraction was performed in each healthy subject during the health examination for the same purpose as in patients. At 6 and 30 days following acute cerebral infarction attack, CT examination was performed for calculation of cerebral infarction volume according to the Tada formula. Following admission and at 30 days of disease invasion, all patients were scored by the National Institutes of Health Stroke Scale (NIHSS, 13 items).MAIN OUTCOME MEASURES: Comparison of NSE plasma level between acute cerebral infarction patients and healthy individuals; correlations of NSE plasma level in acute cerebral infarction patients with cerebral infarction volume, NIHSS score, and prognosis.RESULTS: Following admission and at days 6 and 12 of disease invasion, the plasma level

  17. Effect of dichloracetate on infarct size in a primate model of focal cerebral ischaemia.

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    Chandy M

    2000-07-01

    Full Text Available Acidosis is a major contributing factor towards spread of the ischaemic focus in the brain. Drugs that increase pyruvate dehydrogenase activity could decrease the formation of lactic acidosis. The sodium salt of dichloracetic acid (DCA has been found to be effective in reducing lactate. This study was undertaken to study the efficacy of DCA in reducing infarct size in experimental focal ischaemia in monkeys. Macaca radiata monkeys in the treatment group were given 35 mg per kilogram of dichloracetate intravenously immediately before occluding and interrupting the middle cerebral artery, and the control group was given saline as placebo under similar conditions. Mean infarct size expressed as a percentage of the size of the hemisphere in all the three brain slices was 35.38 in the control group as against l2.06 in the treated group (p=0. 0008.

  18. Combined Ipsilateral Oculomotor Nerve Palsy and Contralateral Downbeat Nystagmus in a Case of Cerebral Infarction

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    Kosuke Matsuzono

    2014-04-01

    Full Text Available We report a patient with acute cerebral infarction of the left paramedian thalamus, upper mesencephalon and cerebellum who exhibited ipsilateral oculomotor nerve palsy and contralateral downbeat nystagmus. The site of the infarction was considered to be the paramedian thalamopeduncular and cerebellar regions, which are supplied by the superior cerebellar artery containing direct perforating branches or both the superior cerebellar artery and the superior mesencephalic and posterior thalamosubthalamic arteries. Contralateral and monocular downbeat nystagmus is very rare. Our case suggests that the present downbeat nystagmus was due to dysfunction of cerebellar-modulated crossed oculovestibular fibers of the superior cerebellar peduncle or bilateral downbeat nystagmus with one-sided oculomotor nerve palsy.

  19. The use of magnetic resonance and MR angiography in the detection of cerebral infarction: A complication of pediatric bacterial meningitis

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    Stošić-Opinćal Tatjana

    2005-01-01

    Full Text Available Bacground. Association of both cerebral infarction and acute bacterial meningitis is more common in younger patients than in the elderly. The rate of mortality and the frequency of sequel are very high inspite of the use of modern antibiotic therapy. In more than 30% of the cases of childhood bacterial meningitis, both arterial and venous infarctions can occur. The aim of this study was to present the role of the use of magnetic resonance (MRI, and MR angiography (MRA in the detection of bacterial meningitis in children complicated with cerebral infarctions. Method. In the Centre for MR, the Clinical Centre of Serbia, 25 patients with the diagnosis of bacterial meningitis, of which 9 children with cerebral infarction whose clinical conditon deteriorated acutely, despite the antibiotic therapy, underwent MRI and MR angiography examination on a 1T scanner. Examination included the conventional spin-echo techniques with T1-weighted saggital and coronal, and T2- weighted axial and coronal images. Coronal fluid attenuated inversion recovery (FLAIR and the postcontrast T1-weighted images in three orthogonal planes were also used. The use MR angiography was accomplished by the three-dimensional time-of-flight (3D TOF technique. Results. The findings included: multiple hemorrhagic infarction in 4 patients, multiple infarctions in 3 patients, focal infarction in 1 patient and diffuse infarction (1 patient. Common sites of involvement were: the frontal lobes, temporal lobes and basal ganglia. The majority of infarctions were bilateral. In 3 of the patients empyema was found, and in 1 patient bitemporal abscess was detected. In 8 of the patients MR angiography confirmed inflammatory vasculitis. Conclusion. Infarction is the most common sequel of severe meningitis in children. Since the complication of cerebral infarction influences the prognosis of meningitis, repetitive MRI examinations are very significant for the evaluation of the time course of

  20. The GPVI-Fc fusion protein Revacept improves cerebral infarct volume and functional outcome in stroke.

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    Silvia Goebel

    Full Text Available OBJECTIVES: We examined the effect of Revacept, an Fc fusion protein which is specifically linked to the extracellular domain of glycoprotein VI (GPVI, on thrombus formation after vessel wall injury and on experimental stroke in mice. BACKGROUND: Several antiplatelet drugs for the treatment of myocardial infarction or ischemic stroke with potent anti-ischemic effects have been developed, but all incur a significant risk of bleeding. METHODS: Platelet adhesion and thrombus formation after endothelial injury was monitored in the carotid artery by intra-vital fluorescence microscopy. The morphological and clinical consequences of stroke were investigated in a mouse model with a one hour-occlusion of the middle cerebral artery. RESULTS: Thrombus formation was significantly decreased after endothelial injury by 1 mg/kg Revacept i.v., compared to Fc only. 1 mg/kg Revacept i.v. applied in mice with ischemic stroke immediately before reperfusion significantly improved functional outcome, cerebral infarct size and edema compared to Fc only. Also treatment with 10 mg/kg rtPA was effective, and functional outcome was similar in both treatment groups. The combination of Revacept with rtPA leads to increased reperfusion compared to treatment with either agent alone. In contrast to rtPA, however, there were no signs of increased intracranial bleeding with Revacept. Both rtPA and Revacept improved survival after stroke compared to placebo treatment. Revacept and vWF bind to collagen and Revacept competitively prevented the binding of vWF to collagen. CONCLUSIONS: Revacept reduces arterial thrombus formation, reduces cerebral infarct size and edema after ischemic stroke, improves functional and prognostic outcome without intracranial bleeding. Revacept not only prevents GPVI-mediated, but probably also vWF-mediated platelet adhesion and aggregate formation. Therefore Revacept might be a potent and safe tool to treat ischemic complications of stroke.

  1. INTRANASAL DELIVERY OF NERVE GROWTH FACTOR TO PROTECT THE CENTRAL NERVOUS SYSTEM AGAINST ACUTE CEREBRAL INFARCTION

    Institute of Scientific and Technical Information of China (English)

    Hong-mei Zhao; Xin-feng Liu; Xiao-wei Mao; Chun-fu Chen

    2004-01-01

    Objective To confirmed reliability and feasibility of intranasal nerve growth factor (NGF) bypassing the blood-brain barrier and its potential neuroprotective effects on acute cerebral ischemia.Methods (1) To assay NGF concentrations in different brain regions after middle cerebral artery occlusion (MCAO).Rats were randomly divided into intranasal (IN) NGF, intravenous (Ⅳ) NGF, and untreated group (n =4). The concentrations of NGF of different brain regions in the three groups after MCAO were measured by ELISA. (2) To observe neuroprotective action of NGF on focal cerebral ischemic damage. Rats were randomly assigned to 4 groups: IN vehicle, IN NGF,Ⅳ vehicle, Ⅳ NGF (n = 8). Treatment was initiated 30 minutes after onset of MCAO and given again 24 hours later. Three neurologic behavioral tests were performed 24 and 48 hours following onset of MCAO. Corrected infarct volumes were determined 48 hours after onset of MCAO.Results The olfactory bulb in IN NGF group obtained the highest concentration (3252 pg/g) of NGF among all regions, followed by the hippocumpus. The NGF concentrations in the olfactory bulb and hippocampus in IN NGF group were markedly higher than that in Ⅳ NGF and control groups. The infarct volume in IN NGF group was markedly reduced by 38.8% compared with IN vehicle group. IN NGF group vestibulum function markedly improved compared with IN vehicle group at 24 and 48 hours after onset of MCAO (P24h = 0.02 and P48h = 0.04, respectively).Conclusion Intranasal NGF could pass through the blood-brain barrier, reach the central nervous system, reduce infarct volume, and improve neurologic function in rats following MCAO. Intranasal delivery of NGF may be a promising treatment for stroke.

  2. 脑梗死患者脑血管血液动力学变化与功能障碍相关性研究%Correlation of hemodynamic change of cerebral vessels and functional disturbance in cerebral infarction patient

    Institute of Scientific and Technical Information of China (English)

    王伯良; 王俊卿

    2001-01-01

    Objective To observe and investigate the correlation of hemodynamic change of cerebral vessels and functional disturbance in cerebral infarction patient.Methods To investigate hemodynamic characters of cerebral vessels in every type and every group patients via comparing cerebral infarction group(observe group)with control group,comparing stage of recovery with early stage, sever, moderate, mild degree in observe group.Results Apparent hemodynamic change was observed in above 94.10% cerebral infarction patients. The more apparent the hemodynamic change,the severer the functional disturbance.Conclusion The hemodynamic change of cerebral vessels is the predictive index of state of illness and prognosis of cerebral infarction patient.Clinical doctor should pay enough attention to modify it in treatment.

  3. 高压氧治疗脑梗死疗效观察%Observation of therapeutic effect of hyperbaric oxygen on cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    马维艳; 杨丽

    2002-01-01

    Background:Hypoxia and ischemia resulting from cerebral infarction can further cause a series of pathological changes such as hydrocephallus.Drug therapy can improve cerebral blood circulation and enhance flow volume and decrease infarction area.If hyperbaric oxygen is added,pathophysiological changes such as ischemia and hypoxia can be improved and normal metabolism of brain cells be restored.

  4. The study on the relationship between the level of serum CysC and atrial fibrillation in patients with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    刘萍

    2013-01-01

    Objective To investigate the relationship between the level of serum cystatin C(CysC) and atrial fibrillation(AF) in patients with acute cerebral infarction(ACI).Methods Two hundred fifty-three patients with acute cerebral infarction were divided into ACI with AF group

  5. Acute Headache at Emergency Department: Reversible Cerebral Vasoconstriction Syndrome Complicated by Subarachnoid Haemorrhage and Cerebral Infarction

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    M. Yger

    2015-01-01

    Full Text Available Introduction. Reversible cerebral vasoconstriction syndrome is becoming widely accepted as a rare cause of both ischemic and haemorrhagic stroke and should be evocated in case of thunderclap headaches associated with stroke. We present the case of a patient with ischemic stroke associated with cortical subarachnoid haemorrhage (cSAH and reversible diffuse arteries narrowing, leading to the diagnosis of reversible vasoconstriction syndrome. Case Report. A 48-year-old woman came to the emergency department because of an unusual thunderclap headache. The computed tomography of the brain completed by CT-angiography was unremarkable. Eleven days later, she was readmitted because of a left hemianopsia. One day after her admission, she developed a sudden left hemiparesis. The brain MRI showed ischemic lesions in the right frontal and occipital lobe and diffuse cSAH. The angiography showed vasoconstriction of the right anterior cerebral artery and stenosis of both middle cerebral arteries. Nimodipine treatment was initiated and vasoconstriction completely regressed on day 16 after the first headache. Conclusion. Our case shows a severe reversible cerebral vasoconstriction syndrome where both haemorrhagic and ischemic complications were present at the same time. The history we reported shows that reversible cerebral vasoconstriction syndrome is still underrecognized, in particular in general emergency departments.

  6. Delayed cerebral infarction due to stent folding deformation following carotid artery stenting

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Kwon Duk; Lee, Kyung Yul; Suh, Sang Hyun [Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul (Korea, Republic of); Kim, Byung Moon [Dept. of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2014-12-15

    We report a case of delayed cerebral infarction due to stent longitudinal folding deformation following carotid artery stenting using a self-expandable stent with an open-cell design. The stented segment of the left common carotid artery was divided into two different lumens by this folding deformation, and the separated lumens became restricted with in-stent thrombosis. Although no established method of managing this rare complication exists, a conservative approach was taken with administration of anticoagulant and dual antiplatelet therapy. No neurological symptoms were observed during several months of clinical follow-up after discharge.

  7. Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction.

    Science.gov (United States)

    Jensen, Jens H; Falangola, Maria F; Hu, Caixia; Tabesh, Ali; Rapalino, Otto; Lo, Calvin; Helpern, Joseph A

    2011-06-01

    By application of the MRI method of diffusional kurtosis imaging, a substantially increased diffusional kurtosis was observed within the cerebral ischemic lesions of three stroke subjects, 13-26 h following the onset of symptoms. This increase is interpreted as probably reflecting a higher degree of diffusional heterogeneity in the lesions when compared with normal-appearing contralateral tissue. In addition, for two of the subjects with white matter infarcts, the increase had a strong fiber tract orientational dependence. It is proposed that this effect is consistent with a large drop in the intra-axonal diffusivity, possibly related to either axonal varicosities or alterations associated with the endoplasmic reticulum.

  8. No effect of ablation of surfactant protein-D on acute cerebral infarction in mice

    DEFF Research Database (Denmark)

    Lambertsen, Kate Lykke; Østergaard, Kamilla; Clausen, Bettina Hjelm;

    2014-01-01

    -induced increase in TNF mRNA production one day after induction of ischemia; however the TNF response to the ischemic insult was affected at five days. SP-D mRNA was not detected in parenchymal brain cells in either naïve mice or in mice subjected to focal cerebral ischemia. However, SP-D mRNA was detected...... were comparable in SP-D KO and WT mice. CONCLUSIONS: SP-D synthesis in middle cerebral artery cells is consistent with SP-D conceivably leaking into the infarcted area and affecting local cytokine production. However, there was no SP-D synthesis in parenchymal brain cells and ablation of SP-D had...

  9. CT perfusion during delayed cerebral ischemia after subarachnoid hemorrhage: distinction between reversible ischemia and ischemia progressing to infarction

    Energy Technology Data Exchange (ETDEWEB)

    Cremers, Charlotte H.P. [University Medical Center Utrecht, Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, PO Box 85500, Utrecht, Utrecht (Netherlands); University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Vos, Pieter C. [University Medical Center Utrecht, Image Sciences Institute, Utrecht (Netherlands); Schaaf, Irene C. van der; Velthuis, Birgitta K.; Dankbaar, Jan Willem [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Vergouwen, Mervyn D.I.; Rinkel, Gabriel J.E. [University Medical Center Utrecht, Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, PO Box 85500, Utrecht, Utrecht (Netherlands)

    2015-09-15

    Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) can be reversible or progress to cerebral infarction. In patients with a deterioration clinically diagnosed as DCI, we investigated whether CT perfusion (CTP) can distinguish between reversible ischemia and ischemia progressing to cerebral infarction. From a prospectively collected series of aSAH patients, we included those with DCI, CTP on the day of clinical deterioration, and follow-up imaging. In qualitative CTP analyses (visual assessment), we calculated positive and negative predictive value (PPV and NPV) with 95 % confidence intervals (95%CI) of a perfusion deficit for infarction on follow-up imaging. In quantitative analyses, we compared perfusion values of the least perfused brain tissue between patients with and without infarction by using receiver-operator characteristic curves and calculated a threshold value with PPV and NPV for the perfusion parameter with the highest area under the curve. In qualitative analyses of 33 included patients, 15 of 17 patients (88 %) with and 6 of 16 patients (38 %) without infarction on follow-up imaging had a perfusion deficit during clinical deterioration (p = 0.002). Presence of a perfusion deficit had a PPV of 71 % (95%CI: 48-89 %) and NPV of 83 % (95%CI: 52-98 %) for infarction on follow-up. Quantitative analyses showed that an absolute minimal cerebral blood flow (CBF) threshold of 17.7 mL/100 g/min had a PPV of 63 % (95%CI: 41-81 %) and a NPV of 78 % (95%CI: 40-97 %) for infarction. CTP may differ between patients with DCI who develop infarction and those who do not. For this purpose, qualitative evaluation may perform marginally better than quantitative evaluation. (orig.)

  10. 高血糖对急性脑梗死的影响%Effects of hyperglycemia on acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    李静; 张芳芳; 韩玉华

    2012-01-01

      Objective To study the effect of hyperglycemia on acute cerebral infarction. Methods Detection of 93 cases of acute cerebral infarction patients following the onset of impaired fasting glucose. According to the history of diabetes, blood glucose level, divided into diabetic group, stress hyperglycemia group and the normal blood glucose group. Observed three groups of cerebral infarction exacerbation and prognosis. Results The progression incidence of Cerebral infarction diabetes group was higher than that of stress hyperglycemia group and the normal blood glucose group. Three was significantly different (P<0.01 )among three groups .Conclusion Cerebral infarction progression is related with hyperglycemia and with poor prognosis. So we should avoid hyperglycemia factors to reduce cerebral infarction exacerbation.%  目的探讨高血糖对急性脑梗死的影响.方法检测93例急性脑梗死患者发病后空腹血糖,根据糖尿病史、血糖值高低,分为糖尿病组、应激性高血糖组和血糖正常组,观察3组脑梗死进展发生率和预后.结果糖尿病组脑梗死进展发生率高于应激性高血糖组和血糖正常组,且3组预后有显著性差异(P<0.01).结论脑梗死加重与高血糖有明显关系,且预后不良,故应尽量避免引起血糖增高的因素,以减少脑梗死加重.

  11. Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis

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    Min Ho Cha

    2015-01-01

    Full Text Available Blood stasis (BS is characterized as a disorder of blood circulation. In traditional Korean medicine (TKM, it is viewed as a cause factor of diseases such as multiple sclerosis and stroke. This study investigated differences in the plasma metabolites profiles of subjects displaying BS or non-BS patterns. Thirty-one patients with cerebral infarction diagnosed with BS and an equal number of sex- and age-matched non-BS patients were enrolled. Metabolic profiling was performed using UPLC-MS. The ratio of subjects with a rough pulse and purple coloration of the tongue was higher in patients presenting with BS pattern. Through metabolomics analysis, 82 metabolites that differed significantly between the BS and non-BS pattern were identified, and the two groups were significantly separated using an orthogonal partial least square-discriminant analysis model (P<0.001. Of these 82 metabolites, acetyl carnitine, leucine, kynurenine, phosphocholine, hexanoyl carnitine, and decanoyl carnitine were present in significantly higher levels in patients with a BS pattern than those with a non-BS pattern. Our results also demonstrated that seven plasma metabolites, including acyl-carnitines and kynurenine, were associated with a BS pattern, suggesting that variant plasma metabolic profiles may serve as a biomarker for diagnosis of BS in patients with cerebral infarction.

  12. Aortic Valve Papillary Fibroelastoma Associated with Acute Cerebral Infarction: A Case Report

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    Nobuhiro Takeuchi

    2013-01-01

    Full Text Available An 80-year-old woman with a history of congestive heart failure, atrial fibrillation, and hypertension was transferred to our institution with hematemesis. Her drug regimen included 2 mg warfarin potassium/day to prevent thromboembolic events. Transthoracic echocardiography (TTE performed at 78 years of age revealed a mass attached to the noncoronary cusp and a cardiac tumor was suspected. The patient declined surgery and was meticulously followed up with periodic TTE. Upper gastroendoscopy revealed a gastric ulcer with an exposed blood vessel; anticoagulant therapy was ceased. On day 15 of admission, acute cerebral infarction occurred. Heparin sodium and warfarin potassium were administered rapidly, and her symptoms improved. TTE revealed no alteration of the mobile, string-like mass attached to the noncoronary cusp. Cardiac tumor was considered the cause of cerebral infarction, and the patient consented to surgical therapy. Pathological examination of the resected tumor suggested papillary fibroelastoma (PFE. Although no guidelines exist for PFE management, a mobile, cardiac tumor necessitates surgical resection to prevent thromboembolic events, even when small in size.

  13. Akinetic Mutism Following Bilateral Anterior Cerebral Artery Territory Infarction Due to Aneurysm: A Case Report

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    Zeynep Özözen Ayas

    2014-04-01

    Full Text Available BACKGROUND AND PURPOSE: Bilateral anterior cerebral artery (ACA territory infarction is rare localization in stroke which should always prompt a search for an anterior communicating artery (ACoA aneurysm. The common neurological manifestations are contralateral weakness predominate in the lower extremite, behavior disturbance, motor inertia, muteness, incontinence, grasp reflex, diffuse rigidity, akinetic mutism. CASE DESCRIPTION: We describe a 38-year-old woman presented with a left sided hemiparesia and decrease of speech for last days. She was a smoker and morbide obese. She had no any diagnosed disease. Her neurological examination had weakness of left extremites affected leg more than the arm and akinetic mutism like as no spontaneously speech and move and grasp reflex. CT showed bilateral ACA infarction which included cingulate gyrus, the right side more than left and subarachnoid hemorrhage in the interhemispheric fissure. MRI angiography showed the appearance of AcoA aneurysm. CONCLUSION: We report a patient with bilateral infarction in the ACA which a rare localization and clinicians must be alert to exist AcoA aneurysm which may bleed, different symptoms and signs like as akinetic mutism, primitive reflexes.

  14. Large deep infarcts found in proximal middle cerebral artery steno-occlusive disease: MRI and angiographic findings

    Energy Technology Data Exchange (ETDEWEB)

    Yi, Bum Ha; Kim, Eui Jong; Choi, Woo Suk; Jang, Dae Il; Chung, Kyung Cheon; Oh, Joo Hyung; Yoon, Yup; Hong, Hoon Pyo [Kyunghee Univ. Hospital, Seoul (Korea, Republic of)

    1998-11-01

    To determine the nature of large deep-seated infarcts without cortical infarct in patients with steno-occlusive disease of the proximal middle cerebral artery (MCA) using magnetic resonance images (MRI) and angiography. By means of MRI and MR angiography (MRA), we examined 24 patients with large deep cerebral infarctions (>3cm in size) involving the basal ganglia, corona radiata and/or centrum semiovale, as well as steno-occlusive lesion of the proximal MCA. According to location, infarctions were classified into five groups, as follows:Group 1:basal ganlgia and corona radiata; 2:basal ganglia, corona radiata and centrum semiovale;3:corona radiata and centrum semiovale;4:corona radiata;5:basal ganglia only. We evaluated the topography of the lesions and correlated the results with the findings of angiography (all 24 MRA;the 13:conventional angiography). Involvement of the head of the caudate nucleus and the internal capsule were also evaluated. Fifteen of 24 cases (63%) were assigned to group 1 (4 proximal MCA(M1) occlusion and 11 stenosis), and five of 24 (21%) with M1 occlusions to group 2. Group 3 comprised only one case with M1 occlusion. Two cases with both occlusion and stenosis were included in group 4, and only one case-with M1 stenosis-in group 5. Infarctions at the caudate nucleus were seen in five cases, and at the internal capsule in two. On conventional angiography (13 cases) cortical branches of the MCA were delineated through the leptomeningeal collaterals of anterior or posterior cerebral arteries. Most large deep cerebral infarctions found in proximal MCA diseases are thought to extend cephalad to the corona radiata. When large deep-seated infarctions with proximal MCA occlusion is observed more frequently than stenosis.=20.

  15. Efficiency and safety evaluation of Baimaiointment for alleviating hypermyotonia following cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: Baimai ointment has Shujin and Huoluo efficiency. It has been confirmed by basic pharmacodynamic experiments that Baimai ointment has some therapeutic effects on stroke. However, the detailed evaluations of Baimai ointment on clinically treating stroke patients for function recovery are still insufficient with little reports.OBJECTIVE: To observe the efficiency and safety of Baimai ointment on alleviating hyperrnyotonia following cerebral infarction DESIGN: A randomized, parallel and controlled experiment.SETTING: Department of Neurology, Beijing Aerospace General Hospital.PARTICIPANTS: A total of 120 patients with acute front-cycle cerebral infarction were selected from Department of Neurology, Beijing Aerospace General Hospital from July to December 2006 and met the diagnosis criteria modified by Forth National Seminar on Cerebrovascular Disease. The experiment had got confirmed consent from local ethic committee. All 120 patients with cerebral infarction were randomly divided into experimental group (n =80; 32 in the acute phase, 32 in the recovery phase and 16 in the sequela phase) and control group (n =40; 16 in the acute phase, 16 in the recovery phase and 8 in the sequela phase).METHODS: Within 4 weeks after the patients were enrolled in this study, no other traditional Chinese medicines containing similar components were adopted besides routine supporting therapy. The Baimai ointment being consisted of Jianghuang, Roudoukou, Gansong, Yangqishi, Gancao, She, shannai,Zanghuixiang, Zangchangpu, Huajiao and Jianhua was used by trial group (20 g/ampoule, Tibet Lingzhiqizheng Tibetan Drug Factory; batch number: 050403), 2 3 times per day, the ointment was moderately coated traveling parts of Baimai.MAIN OUTCOME MEASURES: The evaluation of National Institutes of Health Stroke Scale (NIHSS),Modified Rankin Scale and Modified Ashworth Scale were performed before administration, 2 and 4 weeks after administration.RESULTS: All 120 patients with acute front

  16. Soluble epoxide hydrolase gene deletion improves blood flow and reduces infarct size after cerebral ischemia in reproductively senescent female mice

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    Kristen L Zuloaga

    2015-01-01

    Full Text Available Soluble epoxide hydrolase (sEH, a key enzyme in the metabolism of vasodilatory epoxyeicosatrienoic acids (EETs, is sexually dimorphic, suppressed by estrogen, and contributes to underlying sex differences in cerebral blood flow and injury after cerebral ischemia. We tested the hypothesis that sEH inhibition or gene deletion in reproductively senescent (RS female mice would increase cerebral perfusion and decrease infarct size following stroke. RS (15-18 month old and young (3-4 month old female sEH knockout (sEHKO mice and wild type (WT mice were subjected to 45 min middle cerebral artery occlusion (MCAO with laser Doppler perfusion monitoring. WT mice were treated with vehicle or a sEH inhibitor t-AUCB at the time of reperfusion and every 24hrs thereafter for 3 days. Differences in regional cerebral blood flow were measured in vivo using optical microangiography. Infarct size was measured 3 days after reperfusion. Infarct size and cerebral perfusion 24h after MCAO were not altered by age. Both sEH gene deletion and sEH inhibition increased cortical perfusion 24h after MCAO. Neither sEH gene deletion nor sEH inhibition reduced infarct size in young mice. However, sEH gene deletion, but not sEH inhibition of the hydrolase domain of the enzyme, decreased infarct size in RS mice. Results of these studies show that sEH gene deletion and sEH inhibition enhance cortical perfusion following MCAO and sEH gene deletion reduces damage after ischemia in RS female mice; however this neuroprotection in absent is young mice.

  17. Effects of transection of cervical sympathetic trunk on cerebral infarct volume and oxygen free radical levels in rats with focal cerebral ischemia/reperfusion injury

    Institute of Scientific and Technical Information of China (English)

    Liangzhi Xiong; Yongxia Shi; Feng Xiao; Qingxiu Wang

    2008-01-01

    BACKGROUND: Stellate ganglion block (SGB) plays a protective role on the brain, but the precise mechanism of action is not clear.OBJECTIVE: To simulate SGB by transection of the cervical sympathetic trunk (TCST) and to investigate the TCST effects on changes in cerebral infarct volume and oxygen free radical levels in rats with focal cerebral ischemia/reperfusion injury.DESIGN, TIME AND SETTING: A complete randomized control animal experiment was performed at the Institute of Neurological Diseases of Taihe Hospital, Yunyang Medical College from February to December 2005.MATERIALS: A total of 101 healthy Wistar rats, weighing 280-320g, of both genders, aged 17-18 weeks, were used in this study. 2,3,5-triphenyltetrazolium chloride (TTC) was purchased from Changsha Hongyuan Biological Company. Superoxide dismutase (SOD), malondialdehyde (MDA) and nitric oxide (NO) assay kits were provided by Nanjing Jiancheng Bioengineering Institute.METHODS: Rats were randomly divided into a TCST group, a model group and a sham operation group. Successful models were included in the final analysis, with at least 20 rats in each group. After TCST, rat models of focal cerebral ischemia/reperfusion injury were established in the TCST group by receiving middle cerebral artery occlusion (MCAO) by the intraluminal suture method for 2 hours, followed by 24 hours of reperfusion. Rat models of focal cerebral ischemia/reperfusion injury were made in the model group. Rats in the sham operation group underwent experimental procedures as for the model group, threading depth of 10mm, and middle cerebral artery was not ligated.MAIN OUTCOME MEASURES: Brain tissue sections of ten rats from each group were used to measure cerebral infarct volume by TTC staining. Brain tissue homogenate of another ten rats from each group was used to detect SOD activities, MDA contents and NO levels. Rat neurological function was assessed by neurobehavioral measures.RESULTS: Cerebral infarct volume was bigger in the

  18. Hyperbaric oxygen therapy for cerebral blood flow and electroencephalogram in patients with acute cerebral infarction Choice for therapeutic occasion

    Institute of Scientific and Technical Information of China (English)

    Lei Chen; Fei Li; Dexiang Gu

    2007-01-01

    BACKGROUND: Hyperbaric oxygen (HBO) therapy increases blood oxygen content, changes cerebral blood flow (CBF) and cerebral metabolism. Its therapeutic effects on cerebrovascular disease have been fully confirmed, but the occasion for HBO therapy is still unclear.OBJECTIVE: To observe the therapeutic effects of HBO therapy at different time on CBF and electroencephalogram (EEG) in patients with acute cerebral infarction (CI).DESIGN: Randomized controlled trial.SETTING: Department of Neurology, Shidong Hospital, Yangpu District of Shanghai.PARTICIPANTS: Ninety-six inpatients with acute CI, admitted to Department of Neurology, Shidong Hospital, Yangpu District of Shanghai from January 2001 to December 2006, were involved in this experiment. The involved participants met the diagnosis criteria of acute CI and confirmed by skull CT or MRI. They all were patients with moderate CI (16- 30 points) according to neurologic deficit score formulated by Chinese Medical Association. Informed consents of detected items and therapeutic regimen were obtained from all the involved participants. They were randomized into two groups with 48 in each:early-stage treatment group and advanced-stage treatment group. Among the 48 patients in the early-stage treatment group, 21 male and 27 female, aged 53 -68 years, 22 patients were found with basal ganglia infarction, 10 with brain lobe infarction, 16 with multiple infarction, 27 accompanied with hypertension and 2 accompanied with diabetes mellitus. Among the 48 patients in the advanced-stage treatment group, 23 male and 25 female, aged 52 - 71 years, 25 patients were found with basal ganglia infarction, 10 with brain lobe infarction, 12 with multiple infarction, 1 with brain stem infarction, 28 accompanied with hypertension and 1 accompanied with diabetes mellitus.METHODS: After admission, patients of two groups received routine drug treatment. ① Patients in the early-stage treatment group and advanced-stage treatment group began to

  19. Decompressive craniectomy for malignant middle cerebral artery infarction: Impact on mortality and functional outcome

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    Mohammed Azman Mohammad Raffiq

    2014-01-01

    Full Text Available Background: Malignant middle cerebral artery (MCA infarction is a devastating clinical entity affecting about 10% of stroke patients. Decompressive craniectomy has been found to reduce mortality rates and improve outcome in patients. Methods: A retrospective case review study was conducted to compare patients treated with medical therapy and decompressive surgery for malignant MCA infarction in Hospital Kuala Lumpur over a period of 5 years (from January 2007 to December 2012. A total of 125 patients were included in this study; 90 (72% patients were treated with surgery, while 35 (28% patients were treated with medical therapy. Outcome was assessed in terms of mortality rate at 30 days, Glasgow Outcome Score (GOS on discharge, and modified Rankin scale (mRS at 3 and 6 months. Results: Decompressive craniectomy resulted in a significant reduction in mortality rate at 30 days (P < 0.05 and favorable GOS outcome at discharge (P < 0.05. Good functional outcome based on mRS was seen in 48.9% of patients at 3 months and in 64.4% of patients at 6 months (P < 0.05. Factors associated with good outcome include infarct volume of less than 250 ml, midline shift of less than 10 mm, absence of additional vascular territory involvement, good preoperative Glasgow Coma Scale (GCS score, and early surgical intervention (within 24 h (P < 0.05. Age and dominant hemisphere infarction had no significant association with functional outcome. Conclusion: Decompressive craniectomy achieves good functional outcome in, young patients with good preoperative GCS score and favorable radiological findings treated with surgery within 24 h of ictus.

  20. Simultaneous occurrence of diabetic ketoacidosis, thyroid storm, and multiple cerebral infarctions due to Moyamoya disease.

    Science.gov (United States)

    Noh, Byoungho H; Cho, Sang-Won; Ahn, Sung Yeon

    2016-02-01

    Diabetic ketoacidosis (DKA) is one of the precipitating factors that can evoke a thyroid storm. Thyroid storm may cause cerebral ischemia in Moyamoya disease, which can coexist in patients with Graves' disease. A 16-year-old girl complaining of dizziness and palpitations visited the emergency department and was diagnosed with DKA combined with hyperthyroidism. A thyroid storm occurred 6 h after the start of DKA management. Her Burch and Wartofsky score was 65 points. Right hemiplegia developed during the thyroid storm, and brain magnetic resonance (MR) diffusion-weighted images revealed multiple acute infarcts in both hemispheres. MR angiography showed stenosis of both distal internal carotid arteries and both M1 portions of the middle cerebral arteries, consistent with Moyamoya disease. After acute management for the thyroid storm with methimazole, Lugol solution and hydrocortisone, the patient's neurological symptoms completely resolved within 1 month, and free T4 level normalized within 2 months. Thyroid storm may trigger cerebral ischemia in Moyamoya disease and lead to rapid progression of cerebrovascular occlusive disease. As a simultaneous occurrence of DKA, thyroid storm and cerebrovascular accident in Moyamoya disease highly elevates morbidity and mortality, prompt recognition and management are critical to save the patient's life.

  1. Serum cortisol level in cerebral infarction patients with infection and its correlation with nerve function, humoral immunity and cellular immunity

    Institute of Scientific and Technical Information of China (English)

    Jie-Min Zhai; Hui-Qi Li; Jian-Bo He; Hai-Guo Wang

    2016-01-01

    Objective:To analyze the serum cortisol level in cerebral infarction patients with infection and its correlation with nerve function, humoral immunity and cellular immunity.Methods:A total of 86 patients with cerebral infarction were divided into observation group (cerebral infarction combined with infection) (n=40) and control group (cerebral infarction alone) (n=46) according to the combination of infection. Serum content of cortisol, nerve function-related indexes and humoral immunity indexes as well as peripheral blood levels of cellular immunity indexes of two groups of patients were determined on admission, and the correlation between serum cortisol level and the above illness-related indexes in cerebral infarction patients with infection was further analyzed.Results: Serum cortisol content of observation group was significantly higher than that of control group; serum nerve function indexes S100β, GFAP, Hcy and HO1 content were significantly higher than those of control group while IGF-1 content was significantly lower than that of control group; humoral immunity indexes IgA, IgM, IgG, C3 and C4 content in serum were significantly lower than those of control group; cellular immunity indexes CD3+, CD4+ and CD54+T lymphocyte content in peripheral blood were significantly lower than those of control group while CD19+T lymphocyte content and CD4+/CD8+ level were significantly higher than those of control group; hemodynamic indexes rCBF and rCBV levels were significantly lower than those of control group while MTT, TTP and DLY levels were significantly higher than those of control group. Serum cortisol level in cerebral infarction patients with infection was directly correlated with the levels of nerve function, humoral immunity, cellular immunity and other illness-related indexes. Conclusions:The high cortisol state in cerebral infarction patients with infection is the visual sign of severe nerve function damage and suppressed immune function, and it can be a

  2. Evaluation of corticospinal tract injury with three-dimensional diffusion tensor tract in patients with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Hui Xiao; Ziqian Chen; Biyun Zhang; Ping Ni

    2006-01-01

    BACKGROUND: Three-dimensional diffusion tensor tract (DTT) is the newest imaging to describe the structure of white matter fiber in three-dimensions, it has great significance in dividing the concrete anatomic site of gray and white matter lesions, displaying the correlation with fibrous band and judging clinical prognosis, which is incomparable by other imagings.OBJECTTVE: To observe the conditions of corticospinal tract (CST) in acute cerebral ischemic stroke patients,and analyze the relationship between motor function and the severity of CST injury.DESIGN: A case-control observation.SETTTNG: Department of Medical Imaging, Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA.PARTTCTPANTS: Fifteen patients with acute cerebral infarction were selected from Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA from February to December in 2005. They all suffered from acute attack and motor disorder of hemiplegic limbs to different extent, and were conformed by CT or MRI.There were 9 males and 6 females, aging 16-87 years old, the median age was 51.7 years, and all were right handed. Fifteen right-handed normal subjects, who were matched by age and sex with the patients in the cerebral infarction group, were selected from the relatives of patients and physicians of the Imaging Department as the control group. All the subjects were informed and agreed with the study.METHODS: The patients with acute cerebral infarction and subjects in the control group received MR diffusion tensor imaging (DTI) with GE 1.5 T nuclear magnetic resonance system, fiber tracking with the software of dTV- Ⅱ. Fractional anisotropy (FA) maps and three-dimensional tractography of bilateral CST of all patients were created. Displacement, continuity and destroy of fibrous bands were observed. At the same time, muscle strength of ipsilateral hand of patients with cerebral infarction was measured with Brunnstrom standard. The correlation between the severity

  3. Fetal-Type Variants of the Posterior Cerebral Artery and Concurrent Infarction in the Major Arterial Territories of the Cerebral Hemisphere

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    Stephen L. Lambert BS

    2016-09-01

    Full Text Available Fetal-type or fetal posterior cerebral artery (FPCA is a variant of cerebrovascular anatomy in which the distal posterior cerebral artery (PCA territory is perfused by a branch of the internal carotid artery (ICA. In the presence of FPCA, thromboembolism in the anterior circulation may result in paradoxical PCA territory infarction with or without concomitant infarction in the territories of the middle (MCA or the anterior (ACA cerebral artery. We describe 2 cases of FPCA and concurrent acute infarction in the PCA and ICA territories—right PCA and MCA in Patient 1 and left PCA, MCA, and ACA in Patient 2. Noninvasive angiography detected a left FPCA in both patients. While FPCA was clearly the mechanism of paradoxical infarction in Patient 2, it turned out to be an incidental finding in Patient 1 when evidence of a classic right PCA was uncovered from an old computed tomography scan image. Differences in anatomical details of the FPCA in each patient suggest that the 2 FPCAs are developmentally different. The FPCA of Patient 1 appeared to be an extension of the embryonic left posterior communicating artery (PcomA. Patient 2 had 2 PCAs on the left (PCA duplication, classic bilateral PCAs, and PcomAs, and absent left anterior choroidal artery (AchoA, suggesting developmental AchoA-to-FPCA transformation on the left. These 2 cases underscore the variable anatomy, clinical significance, and embryological origins of FPCA variants.

  4. EFFECT OF ELECTROACUPUNCTURE ON PLASMA ANGIOTENSIN-ALDOSTERONE AND ATRIAL NATRIURETIC POLYPEPTIDE IN RABBITS WITH ACUTE CEREBRAL INFARCTION

    Institute of Scientific and Technical Information of China (English)

    吴绪平; 王述菊; 刘玲; 周华

    2004-01-01

    Objective: To observe the therapeutic effect of electroacupuncture (EA) on plasma angiotensin (Ang*.Ⅱ), aldosterone (ALD) and atrial natriuretic polypeptide (ANP) contents in experimental cerebral infarction rabbits for analyzing the underlying mechanism of acupuncture in ameliorating blood supply of the brain tissue. Methods: A total of 80 rabbits were randomized into control (n=8), pseudo-operation (n=24), model (n=24) and EA (n=24) groups. Cerebral infarction model was established by infusion of self-thrombus into the carotid artery. EA (1 mA, 2 Hz) was applied to "Baihui"(百会GV 20) and "Shuigou"(水沟GV 26) for 30 min, once every 12 hours. Plasma Ang-II, ALD and ANP contents were detected with radioimmunoassay method. In the later 3 groups, blood samples were taken at 6 h, 24 h and 48 h after cerebral ischemia. Results: Compared with control and pseudo-operation groups, Ang-II and ALD contents of model group at 6 h, 24 h and 48 h after cerebral ischemia increased significantly while plasma ANP of the 3 time-courses of model group decreased considerably (P<0.01). In comparison with model group, results showed that Ang-II and ALD contents of EA group decreased significantly whereas ANP level of EA group increased strikingly (P<0.01). Conclusion: Electroacupuncture has the effects of raising plasma ANP level and lowering plasma Ang-II and ALD in cerebral infarction rabbits.

  5. Validity and reliability of Chinese version of Fatigue Impact Scale in cerebral infarction patients

    Institute of Scientific and Technical Information of China (English)

    Chunwei Wu; Zhandong Liu; Yongbo Zhang; Jimei Li; Dexin Wang

    2008-01-01

    BACKGROUND:Post-stroke fatigue has received much attention recently.Three evaluation scales are available,including the Fatigue Impact Scale(FIS).Yet none of these has been proven to be of use in the evaluation of psychological quality after post-stroke fatigue.OBJECTIVE:To introduce FIS into China,and to evaluate the validity and reliability of the Chinese Version in patients with cerebral infarction. DESIGN:Scale evaluation. SETTING:Department of ehabilitation,Beijing Friendship Hospital,Capital Medical University. PARTICIPANTS:A total of 330 patients with cerebral infarction were selected from the Department of Neurology,Beijing Friendship Hospital,Capital Medical University from June 2005 to December 2006.All patients met diagnostic standards from the Fourth National Cerebrovascular Disease Academic Meeting of China Medical Association and were diagnosed with CT or MRI examination.Patients who were not willing to accept scale evaluation were excluded. METHODS:The English version of FIS was translated into Chinese and subsequently translated back to English again.FIS was given to the discharged patients,and they returned them upon completion,h-patients completed and immediately returned the FIS.Validity and reliability of the retrieved scales were ascertained with descriptive and inference analysis. MAIN OUTCOME MEASURES:Total scores and subscale scores of FIS.RESULTS:Out of 330 questionnaires,214 valid questionnaires were deemed valid in total.Six components were extracted in factor analysis,and the total cumulative contribution was 73.919%,which suggested the questionnaire was valid.After correlation analysis,6 components were divided into 3 subscales,including cognitive,physical,and social,which was the same as the English version.The Cronhach a value for the three subscales was 0.937 7,0.918 8,and 0.940 6,respectively(>0.7).CONCLUSION:The reliability and validity of the Chinese version of FIS met with satisfaction and appeared to be adaptable to cerebral

  6. Surgery-related thrombosis critically affects the brain infarct volume in mice following transient middle cerebral artery occlusion.

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    Xiaojie Lin

    Full Text Available Transient middle cerebral artery occlusion (tMCAO model is widely used to mimic human focal ischemic stroke in order to study ischemia/reperfusion brain injury in rodents. In tMCAO model, intraluminal suture technique is widely used to achieve ischemia and reperfusion. However, variation of infarct volume in this model often requires large sample size, which hinders the progress of preclinical research. Our previous study demonstrated that infarct volume was related to the success of reperfusion although the reason remained unclear. The aim of present study is to explore the relationship between focal thrombus formation and model reproducibility with respect to infarct volume. We hypothesize that suture-induced thrombosis causes infarct volume variability due to insufficient reperfusion after suture withdrawal. Seventy-two adult male CD-1 mice underwent 90 minutes of tMCAO with or without intraperitoneal administration of heparin. Dynamic synchrotron radiation microangiography (SRA and laser speckle contrast imaging (LSCI were performed before and after tMCAO to observe the cerebral vascular morphology and to measure the cerebral blood flow in vivo. Infarct volume and neurological score were examined to evaluate severity of ischemic brain injury. We found that the rate of successful reperfusion was much higher in heparin-treated mice compared to that in heparin-free mice according to the result of SRA and LSCI at 1 and 3 hours after suture withdrawal (p<0.05. Pathological features and SRA revealed that thrombus formed in the internal carotid artery, middle cerebral artery or anterior cerebral artery, which blocked reperfusion following tMCAO. LSCI showed that cortical collateral circulation could be disturbed by thrombi. Our results demonstrated that suture-induced thrombosis was a critical element, which affects the success of reperfusion. Appropriate heparin management provides a useful approach for improving reproducibility of reperfusion

  7. Changes of biochemical indexes in patients with acute cerebral infarction after treatment with simvastatin

    Institute of Scientific and Technical Information of China (English)

    Cheng Yang

    2006-01-01

    BACKGROUND: At present, it is believed that the important causes of cerebral infarction are the disorders of lipid metabolism and endothelial function, and the outcomes of clinical treatment can be improved by regulating serum lipids and antiinflammation, etc.OBJECTIVE: To observe the effect of simvastatin, inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, on the levels of serum lipids, serum enzymic indexes and inflammatory metabolic indexes in patients with cerebral infarction.DESIGN : A comparative observation.SETTING: Department of Geriatrics, Longquanshan Hospital of Liuzhou City.PARTICIPANTS: Forty-eight patients with acute cerebral infarction wera selected from the Department of Geriatrics of Longquanshan Hospital of Liuzhou from March 2004 to February 2006, including 24 males and 24females, the mean age was (54±12) years, average disease course was (10.0±4.5) days. They were all accorded with the diagnostic standard for cerebral infarction set by the Fourth National Academic Meeting for Cerebrovascular Disease in 1999, and cerebral hemorrhage was excluded by cranial CT scanning. The 48patients were randomly divided into control group (n =24) and traatment group (n =24). Informed consents were obtained from all the participants.METHODS: ① All the patients wera treated according to the symptoms, besides those in the traatment group were given simvastatin (Harbin Pharm. Group Sanjing Pharmaceutical Shareholding, Co.,Ltd., No. H20010454;Batch number: 20040218; 5 mg/tablet). The initial dosage was 10 mg per day for 4 weeks, and then increased to 30 mg per day for another 4 weeks. ② Before treatment and within 1 week after treatment, the total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), aspartate aminotransferase (AST), craatine kinase and C raactive protein in serum were determined with Beckman-cx7 automatic biochemical analytical apparatus in both groups. ③ The

  8. Serum uric acid is a risk factor for large-artery atherosclerosis cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Jianjun Guo; Qingyu Shen; Jie Li; Xiaoming Rong; Ying Peng; Yamei Tang

    2011-01-01

    Using the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification for acute ischemic stroke, 371 patients with either acute large-artery atherosclerosis or small-artery occlusion cerebral infarction were recruited to investigate the potential impact of elevated serum uric acid on cerebrovascular disorders. The results showed that patients who have suffered from large-artery atherosclerosis, relative to small-artery occlusion patients, were characterized by elevated serum uric acid but reduced high-density lipoprotein cholesterol and triglyceride levels. Logistic regression showed that elevated uric acid and lower triglyceride levels were the main risk factors for patients with large-artery atherosclerosis. The findings of this study suggest that hyperuricemia may be a risk factor for stroke.

  9. Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    罗本燕; 陈智; 陈峰; 李霞; 潘小平

    2003-01-01

    Objective : To explore the frequency and significance of ApoE gene polymorphisms in Chinese patiems with atherosclerotic cerebral infarction (ACI). Methods: Polymerase chain reaction and gene sequencing, single nucleotide polymorphisms of ApoE gene were used to analyze 33 cases of patients with ACI and 35 controls. Results: The frequencies of ApoE gene single nucleotide polymorphisms 465C/G, 462C/G and 451delC in the ACI group were significantly higher than those in the control group (P <0.05) . The preva-lence of polymorphism 486G/T in the control group was significantly higher than that in the ACI group ( P =0.011 ). Conclusions : 465 C/G, 462C/G and 451 delC polymorphisms might be associated with ACI. 486GT allele might have protective effect on the pathogenesis of ACI.

  10. Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    罗本燕; 陈智; 陈峰; 李霞; 潘小平

    2003-01-01

    Objective: To explore the frequency and significance of ApoE gene polymorphisms in Chinese patients with atherosclerotic cerebral infarction (ACI). Methods: Polymerase chain reaction and gene sequencing, single nucleotide polymorphisms of ApoE gene were used to analyze 33 cases of patients with ACI and 35 controls. Results: The frequencies of ApoE gene single nucleotide polymorphisms 465C/G, 462C/G and 451delC in the ACI group were significantly higher than those in the control group (P<0.05). The prevalence of polymorphism 486G/T in the control group was significantly higher than that in the ACI group (P=0.011). Conclusions: 465C/G,462C/G and 451delC polymorphisms might be associated with ACI.486GT allele might have protective effect on the pathogenesis of ACI.

  11. Serum Resistin Levels May Contribute to an Increased Risk of Acute Cerebral Infarction.

    Science.gov (United States)

    Dong, Xiao-Liu; Xu, Shi-Jun; Zhang, Li; Zhang, Xiu-Qing; Liu, Ting; Gao, Qiu-Yan; Qian, Qing-Qiang; Sun, Bao-Liang; Yang, Ming-Feng

    2017-04-01

    The objective of this study was to investigate the association between serum resistin levels and acute cerebral infarction (ACI). PubMed, SpringerLink, Wiley, EBSCO, Ovid, Web of Science, Wanfang, China National Knowledge Infrastructure, and VIP databases (last updated search in October 2014) were exhaustively searched, and data from the eligible studies were extracted and analyzed to assess the association between serum resistin levels and ACI. STATA software (version 12.0, Stata Corporation, College Station, TX, USA) was utilized for data analysis. Ten studies including 1829 ACI patients and 1557 healthy controls were eligible for inclusion in the meta-analysis. Our major result revealed that ACI patients exhibited higher serum resistin levels compared with healthy controls. Asubgroup analysis based on ethnicity showed a significant association between serum resistin levels and ACI in Asians, but surprisingly not in Caucasians. The results of our meta-analysis suggest that serum resistin levels are associated with an increased risk of ACI.

  12. Atypical unilateral posterior reversible encephalopathy syndrome mimicking a middle cerebral artery infarction

    Energy Technology Data Exchange (ETDEWEB)

    Camidag, Ilkay [Dept. of Radiology, Ondokuz Mayis University, Faculty of Medicine, Samsun (Turkmenistan); Cho, Yang Je; Park, Mina; Lee, Seung Koo [Yonsei University Severance Hospital, Seoul (Korea, Republic of)

    2015-10-15

    Posterior reversible encephalopathy syndrome (PRES) is usually a reversible clinical and radiological entity associated with typical features on brain MR or CT imaging. However, the not-so-uncommon atypical radiological presentations of the condition are also present and they may go unrecognised as they are confused with other conditions. Here, we report a very rare case of atypical, unilateral PRES in a 49-year-old uremic, post-transplant female patient who presented with seizures. Initial MRI showed high-grade occlusion of the left middle cerebral artery (MCA) and lesions suggestive of subacute infarction in the ipsilateral frontotemporoparietal lobe. Patient symptoms had resolved a day after the onset without any specific treatment but early follow-up CT findings suggested hemorrhagic transformation. Follow-up MRI performed 2 years later showed complete disappearence of the lesions and persisting MCA occlusion.

  13. Treatment of Lacunar Cerebral Infarction with Huo Xue Tong Luo Tang

    Institute of Scientific and Technical Information of China (English)

    侯安会; 王亚威; 郑一

    2001-01-01

    @@Based on our clinical experience,we formulated Huo Xue Tong Luo Tang(活血通络汤HXTL Decoction),a prescription for treatment of lacunar cerebral infarction.Most of the ingredients are those in the prescriptions of Di Dang Tang(抵当汤)and Gui Gan Long Mu Tang(桂甘龙牡汤)described in the book Treatise of Febrile Diseases(伤寒论)in accordance with the compatible theory of principal,assistant,adjuvant and guiding drugs for improving blood circulation,removing stasis,dispelling endogenous wind and phlegm,inducing resuscitation,removing obstruction in the channels,and balancing the yin and yang.

  14. Near-infrared diffuse reflectance imaging of infarct core and peri-infarct depolarization in a rat middle cerebral artery occlusion model

    Science.gov (United States)

    Kawauchi, Satoko; Nishidate, Izumi; Nawashiro, Hiroshi; Sato, Shunichi

    2014-03-01

    To understand the pathophysiology of ischemic stroke, in vivo imaging of the brain tissue viability and related spreading depolarization is crucial. In the infarct core, impairment of energy metabolism causes anoxic depolarization (AD), which considerably increases energy consumption, accelerating irreversible neuronal damage. In the peri-infarct penumbra region, where tissue is still reversible despite limited blood flow, peri-infarct depolarization (PID) occurs, exacerbating energy deficit and hence expanding the infarct area. We previously showed that light-scattering signal, which is sensitive to cellular/subcellular structural integrity, was correlated with AD and brain tissue viability in a rat hypoxia-reoxygenation model. In the present study, we performed transcranial NIR diffuse reflectance imaging of the rat brain during middle cerebral artery (MCA) occlusion and examined whether the infarct core and PIDs can be detected. Immediately after occluding the left MCA, light scattering started to increase focally in the occlusion site and a bright region was generated near the occlusion site and spread over the left entire cortex, which was followed by a dark region, showing the occurrence of PID. The PID was generated repetitively and the number of times of occurrence in a rat ranged from four to ten within 1 hour after occlusion (n=4). The scattering increase in the occlusion site was irreversible and the area with increased scattering expanded with increasing the number of PIDs, indicating an expansion of the infarct core. These results suggest the usefulness of NIR diffuse reflectance signal to visualize spatiotemporal changes in the infarct area and PIDs.

  15. Motor recovery by anterior choroidal artery territory in a patient with middle cerebral artery infarct

    Institute of Scientific and Technical Information of China (English)

    Ji Heon Hong; Sung Ho Jang

    2010-01-01

    In this study,the uninjured periventricular area of a female patient who presented with complete paralysis of the left extremities following middle cerebral artery infarction was analyzed using diffusion tensor tractography,transcranial magnetic stimulation,and functional magnetic resonance imaging.Diffusion tensor tractography revealed interrupted corticospinal tract at the infarct lesion in the corona radiata at 2 weeks after onset,which descended through the spared periventricular area at 6 months after onset.Transcranial magnetic stimulation and functional magnetic resonance imaging revealed a motor pathway of the affected hand that was compatible with the lateral corticospinal tract.At 6 months after onset,motor function in the affected extremities recovered to normal levels,which suggested that motor function in the affected hand recovered by the corticospinal tract that passed through the spared periventricular area.The arterial territory of the spared periventricular area corresponded with the anterior choroidal artery.These results suggest that care should be taken in spared periventricular areas in patients with lesions at the corona radiata level.

  16. Predictors of malignant brain edema in middle cerebral artery infarction observed on CT angiography.

    Science.gov (United States)

    Kim, Hoon; Jin, Seon Tak; Kim, Young Woo; Kim, Seong Rim; Park, Ik Seong; Jo, Kwang Wook

    2015-03-01

    Patients with middle cerebral artery (MCA) infarction accompanied by MCA occlusion with or without internal carotid artery (ICA) occlusion have a poor prognosis, as a result of brain cell damage caused by both the infarction and by space-occupying and life-threatening edema formation. Multiple treatments can reduce the likelihood of edema formation, but tend to show limited efficacy. Decompressive hemicraniectomy with duroplasty has been promising for improving functional outcomes and reducing mortality, particularly improved functional outcomes can be achieved with early decompressive surgery. Therefore, identifying patients at risk for developing fatal edema is important and should be performed as early as possible. Sixty-four patients diagnosed with major MCA infarction with MCA occlusion within 8 hours of symptom onset were retrospectively reviewed. Early clinical, laboratory, and computed tomography angiography (CTA) parameters were analyzed for malignant brain edema (MBE). Twenty of the 64 patients (31%) had MBE, and the clinical outcome was poor (3month modified Rankin Scale >2) in 95% of them. The National Institutes of Health Stroke Scale (NIHSS) score, Alberta Stroke Program Early Computed Tomography Score, Clot Burden Score, and Collateral Score (CS) showed statically significant differences in both groups. Multivariable analyses adjusted for age and sex identified the independent predictors of MBE: NIHSS score >18 (odds ratio [OR]: 4.4, 95% confidence interval [CI]: 1.2-16.0, p=0.023) and CS on CTA <2 (OR: 7.28, 95% CI: 1.7-30.3,p=0.006). Our results provide useful information for selecting patients in need of aggressive treatment such as decompressive surgery.

  17. Excess salt increases infarct size produced by photothrombotic distal middle cerebral artery occlusion in spontaneously hypertensive rats.

    Directory of Open Access Journals (Sweden)

    Hiroshi Yao

    Full Text Available Cerebral circulation is known to be vulnerable to high salt loading. However, no study has investigated the effects of excess salt on focal ischemic brain injury. After 14 days of salt loading (0.9% saline or water, spontaneously hypertensive rats (SHR and normotensive Wistar-Kyoto rats (WKY were subjected to photothrombotic middle cerebral artery occlusion (MCAO, and infarct volume was determined at 48 h after MCAO: albumin and hemoglobin contents in discrete brain regions were also determined in SHR. Salt loading did not affect blood pressure levels in SHR and WKY. After MCAO, regional cerebral blood flow (CBF, determined with two ways of laser-Doppler flowmetry (one-point measurement or manual scanning, was more steeply decreased in the salt-loaded group than in the control group. In SHR/Izm, infarct volume in the salt-loaded group was 112±27 mm3, which was significantly larger than 77±12 mm3 in the control group (p = 0.002, while the extents of blood-brain barrier disruption (brain albumin and hemoglobin levels were not affected by excess salt. In WKY, salt loading did not significantly increase infarct size. These results show the detrimental effects of salt loading on intra-ischemic CBF and subsequent brain infarction produced by phototrhombotic MCAO in hypertensive rats.

  18. A dynamic concept of middle cerebral artery occlusion and cerebral infarction in the acute state based on interpreting severe hyperemia as a sign of embolic migration

    DEFF Research Database (Denmark)

    Olsen, T S; Lassen, N A

    1984-01-01

    The present study investigates the pathogenesis of focal cerebral hyperemia, its effect on brain tissue and discusses its pathophysiological and therapeutic importance in the light of interpreting severe hyperemia as a sign of arterial reopening probably due to embolic migration. Cerebral...... as well as in non-infarcted tissue. Apparently, it is the severity of the initial ischemic episode and not the hyperemia that determines whether or not tissue necrosis develops. Interpreting severe hyperemia as a sign of arterial reopening and embolic migration (evidenced by partial reopening affecting...

  19. Effect of long-term low dose of aspirin on severity of disease following onset of acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Jun Xu; Lili Cao; Xiaomei Deng; Enji Han

    2006-01-01

    BACKGROUND: Aspirin can decrease the incidence risk of high-risk crowdgroup of cerebral infarction, but there are still controversy if it might decrease the degree of disease in degree of patients with acute cerebral infarction.OBJECTIVE: To observe the effect of lower dose of aspirin during taking for a long time on disease degree of disease following onset of acute cerebral infarction.DESIGN: Grouping according to the admission time and 1:1 paired observation.SETTING: Department of Neurology, Qilu Hospital of Shandong University.PARTICIPANTS: The participants in present study were 321 patients with acute cerebral infarction who received treatments in the Department of Neurology, Qilu Hospital of Shandong University from January 1999 to June 2000. There were 190 male and 131 female ,with mean (65±11 )years of age. Inclusive criteria: ① A focal neurological disturbance occurred suddenly and had lasted for more than 24 hours, patients were admitted within 3 days after onset of disease; ② A computed tomography of the brain was performed and excluded hemorrhage in all patients; ③ The patients were proved internal carotid occlusions by clinical features and image findings; ④ The functions of limbs were normal (before the first stroke) or almost normal (before the second stroke). Exclusive criteria: ①The patients who had have cardiogenic cerebral embolism; ②The patients who had taken warfarin orally and other platelet agglutination drugs.METHODS: ①All the patients were divided into 2 groups according to whether they had taken aspirin before: aspirin-treated group (n=110) and blank control group (n=211). There were 70 male and 40 female in aspirin-treated group, with average(65±10) years of age.All patients had taken 50-100 mg/d aspirin for 6 months to 10 years before onset. There were 120 male and 91 female in blank control group, with average (65±13)years of age. Patients received a clinical scoring within 3 days and similar therapeutic measures (such

  20. Filtrate of Phellinus linteus Broth Culture Reduces Infarct Size Significantly in a Rat Model of Permanent Focal Cerebral Ischemia

    Directory of Open Access Journals (Sweden)

    Sakiko Suzuki

    2011-01-01

    Full Text Available Phellinus linteus, a natural growing mushroom, has been known to exhibit anti-tumor, anti-inflammatory, anti-allergic and anti-oxidant effects. Aiming to exploit the neuroprotective effects of P. linteus, we evaluated its effects on infarct volume reduction in a rat model of focal cerebral ischemia. Male Sprague-Dawley rats were subjected to right middle cerebral artery occlusion. Filtrate of P. linteus broth culture (various doses, fractionated filtrate (based on molecular weight or control medium was administered intraperitoneally to rats before or after ischemia induction. Rats were killed at 24 h after the stroke surgery. Cortical and caudoputaminal infarct volumes were determined separately using an image analysis program following staining with 2,3,5-triphenyltetrazolium chloride. Significant cortical infarct volume reductions were found in the pre-treatment groups (30 and 60 minutes before onset of cerebral ischemia compared with the control group, showing dose dependence. Posttreatment (30 minutes after ischemic onset also significantly reduced cortical infarct volume. Furthermore, the higher molecular weight (≥12 000 fraction of the culture filtrate was more effective compared with the lower molecular weight fraction. The present findings suggest that P. linteus may be a new promising approach for the treatment of focal cerebral ischemia, with the additional benefit of a wide therapeutic time window since significant infarct volume reduction is obtained by administration even after the ischemic event. Our finding that the higher molecular weight fraction of the P. linteus culture filtrate demonstrated more prominent effect may provide a clue to identify the neuroprotective substances and mechanisms.

  1. Injury of the corticoreticular pathway in patients with proximal weakness following cerebral infarct: diffusion tensor tractography study.

    Science.gov (United States)

    Do, Kyung Hee; Yeo, Sang Seok; Lee, Jun; Jang, Sung Ho

    2013-06-24

    The corticoreticular pathway (CRP) innervates mainly the proximal muscles of extremities. Identification of the CRP by diffusion tensor tractography (DTT) in the human brain has recently become possible. However, little is known about the relation between proximal weakness and injury of the CRP in stroke patients. In this study, we attempted to investigate the usefulness of DTT for elucidation of the relation between proximal motor weakness and injury of the CRP in patients with cerebral infarct. Among 247 consecutive patients with cerebral infarct, four hemiparetic patients who showed more severe weakness in proximal joints (shoulder and hip) than distal joints (finger and ankle) of the affected extremities were recruited for this study. Evaluation of motor function, DTT, and transcranial magnetic stimulation (TMS) for evaluation of the corticospinal tract state by analysis of the characteristics of the motor-evoked potential were performed at the early stage of cerebral infarct (mean: 17.0 days; range: 11-29). The integrity of the CST on DTT findings in the affected hemisphere was preserved in all four patients and TMS findings in terms of latency and amplitude showed within normal range (one patient) and partial injuries (three patients) of the corticospinal tract. By contrast, on DTT of the CRP in the affected hemispheres, we observed Wallerian degeneration in two patients and discontinuations at infarct level in two patients. The injury of the CRP appeared to attribute the proximal weakness of the shoulder and hip observed in these four patients. Therefore, DTT of the CRP would be useful for elucidating the relation between proximal weakness and injury of the CRP in patients with cerebral infarct.

  2. Filtrate of Phellinus linteus Broth Culture Reduces Infarct Size Significantly in a Rat Model of Permanent Focal Cerebral Ischemia.

    Science.gov (United States)

    Suzuki, Sakiko; Kawamata, Takakazu; Okada, Yoshikazu; Kobayashi, Tomonori; Nakamura, Tomoyuki; Hori, Tomokatsu

    2011-01-01

    Phellinus linteus, a natural growing mushroom, has been known to exhibit anti-tumor, anti-inflammatory, anti-allergic and anti-oxidant effects. Aiming to exploit the neuroprotective effects of P. linteus, we evaluated its effects on infarct volume reduction in a rat model of focal cerebral ischemia. Male Sprague-Dawley rats were subjected to right middle cerebral artery occlusion. Filtrate of P. linteus broth culture (various doses), fractionated filtrate (based on molecular weight) or control medium was administered intraperitoneally to rats before or after ischemia induction. Rats were killed at 24 h after the stroke surgery. Cortical and caudoputaminal infarct volumes were determined separately using an image analysis program following staining with 2,3,5-triphenyltetrazolium chloride. Significant cortical infarct volume reductions were found in the pre-treatment groups (30 and 60 minutes before onset of cerebral ischemia) compared with the control group, showing dose dependence. Posttreatment (30 minutes after ischemic onset) also significantly reduced cortical infarct volume. Furthermore, the higher molecular weight (≥12 000) fraction of the culture filtrate was more effective compared with the lower molecular weight fraction. The present findings suggest that P. linteus may be a new promising approach for the treatment of focal cerebral ischemia, with the additional benefit of a wide therapeutic time window since significant infarct volume reduction is obtained by administration even after the ischemic event. Our finding that the higher molecular weight fraction of the P. linteus culture filtrate demonstrated more prominent effect may provide a clue to identify the neuroprotective substances and mechanisms.

  3. Revisiting Hemicraniectomy: Late Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Stroke and the Role of Infarct Growth Rate

    Science.gov (United States)

    Akhtar, Naveed; Salam, Abdul; Alboudi, Ayman; Kamran, Kainat; Ahmed, Arsalan; Khan, Rabia A.; Mirza, Mohsin K.; Inshasi, Jihad

    2017-01-01

    Objective and Methods. The outcome in late decompressive hemicraniectomy in malignant middle cerebral artery stroke and the optimal timings of surgery has not been addressed by the randomized trials and pooled analysis. Retrospective, multicenter, cross-sectional study to measure outcome following DHC under 48 or over 48 hours using the modified Rankin scale [mRS] and dichotomized as favorable ≤4 or unfavorable >4 at three months. Results. In total, 137 patients underwent DHC. Functional outcome analyzed as mRS 0–4 versus mRS 5-6 showed no difference in this split between early and late operated on patients [P = 0.140] and mortality [P = 0.975]. Multivariate analysis showed that age ≥ 55 years, MCA with additional infarction, septum pellucidum deviation ≥1 cm, and uncal herniation were independent predictors of poor functional outcome at three months. In the “best” multivariate model, second infarct growth rate [IGR2] >7.5 ml/hr, MCA with additional infarction, and patients with temporal lobe involvement were independently associated with surgery under 48 hours. Both first infarct growth rate [IGR1] and second infarct growth rate [IGR2] were nearly double [P < 0.001] in patients with early surgery [under 48 hours]. Conclusions. The outcome and mortality in malignant middle cerebral artery stroke patients operated on over 48 hours of stroke onset were comparable to those of patients operated on less than 48 hours after stroke onset. Our data identifies IGR, temporal lobe involvement, and middle cerebral artery with additional infarct as independent predictors for early surgery.

  4. Relative risk factors analysis of type 2 diabetes combined with cerebral infarction%2型糖尿病合并脑梗死相关危险因素

    Institute of Scientific and Technical Information of China (English)

    张如意; 刘芳; 雷晨; 何兰杰; 薛腊梅

    2003-01-01

    @@ INTRODUCTION Incidence of type 2 diabetes combined with cerebral infarction in-crease with increase of age. High blood sugar, hypertension, hyper-cholesterolemia and high LDL are main risk factors to cerebral in-farction. Obesity is also the risk factor to diabetes combined withcerebral infarction.

  5. Effect of adjuvant argatroban therapy on neurological function, endothelial injury and inflammation state in patient with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Nan Che

    2016-01-01

    Objective:To analyze the effect of adjuvant argatroban therapy on neurological function, endothelial injury and inflammation state in patient with acute cerebral infarction.Methods:A total of 118 patients with acute cerebral infarction were divided into observation group and control group according to the random number table, control group received conventional treatment, observation group received argatroban + conventional treatment, and then differences in TCD cerebral blood flow, serum neurological function, endothelial injury and inflammatory marker levels were compared between two groups after treatment.Results:TCD MCA and ACA values of observation group after treatment were higher than those of control group (P<0.05); serum neurological function indexes copeptin, NT-proBNP, PAO and S-100B levels of observation group after treatment were lower than those of control group, endothelial injury index ET-1 level was lower than that of control group, NO and CGRP levels were higher than those of control group, and inflammatory markers hs-CRP, TNF-α, IL-6, MMP-9 and Lp-PLA2 levels were lower than those of control group (P<0.05).Conclusions:Adjuvant argatroban therapy can optimize the overall condition in patients with acute cerebral infarction, and plays a positive role in improving the neurological function, reducing endothelial injury and inflammation state, etc.

  6. Intra-arterial thrombolysis with r-tPA for the treatment of acute cerebral infarction 6 to 9 hours after onset

    Institute of Scientific and Technical Information of China (English)

    毕敏

    2013-01-01

    Objective To determine the safety and efficacy of intra-arterial recombinant tissue plasminogen activator(r-tPA)for the treatment of acute cerebral infarction(ACI)in patients under the guidance of computed

  7. Effects of leukemia inhibitory factor and basic fibroblast growth factor on free radicals and endogenous stem cell proliferation in a mouse model of cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Weihui Huang; Yadan Li; Yufeng Lin; Xue Ye; Dawei Zang

    2012-01-01

    The present study established a mouse model of cerebral infarction by middle cerebral artery occlusion,and monitored the effect of 25 μg/kg leukemia inhibitory factor and (or) basic fibroblast growth factor administration 2 hours after model establishment.Results showed that following administration,the number of endogenous neural stem cells in the infarct area significantly increased,malondialdehyde content in brain tissue homogenates significantly decreased,nitric oxide content,glutathione peroxidase and superoxide dismutase activity significantly elevated,and mouse motor function significantly improved as confirmed by the rotarod and bar grab tests.In particular,the effect of leukemia inhibitory factor in combination with basic fibroblast growth factor was the most significant.Results indicate that leukemia inhibitory factor and basic fibroblast growth factor can improve the microenvironment after cerebral infarction by altering free radical levels,improving the quantity of endogenous neural stem cells,and promoting neurological function of mice with cerebral infarction.

  8. [Associative visual agnosia. The less visible consequences of a cerebral infarction].

    Science.gov (United States)

    Diesfeldt, H F A

    2011-02-01

    After a cerebral infarction, some patients acutely demonstrate contralateral hemiplegia, or aphasia. Those are the obvious symptoms of a cerebral infarction. However, less visible but burdensome consequences may go unnoticed without closer investigation. The importance of a thorough clinical examination is exemplified by a single case study of a 72-year-old, right-handed male. Two years before he had suffered from an ischemic stroke in the territory of the left posterior cerebral artery, with right homonymous hemianopia and global alexia (i.e., impairment in letter recognition and profound impairment of reading) without agraphia. Naming was impaired on visual presentation (20%-39% correct), but improved significantly after tactile presentation (87% correct) or verbal definition (89%). Pre-semantic visual processing was normal (correct matching of different views of the same object), as was his access to structural knowledge from vision (he reliably distinguished real objects from non-objects). On a colour decision task he reliably indicated which of two items was coloured correctly. Though he was unable to mime how visually presented objects were used, he more reliably matched pictures of objects with pictures of a mime artist gesturing the use of the object. He obtained normal scores on word definition (WAIS-III), synonym judgment and word-picture matching tasks with perceptual and semantic distractors. He however failed when he had to match physically dissimilar specimens of the same object or when he had to decide which two of five objects were related associatively (Pyramids and Palm Trees Test). The patient thus showed a striking contrast in his intact ability to access knowledge of object shape or colour from vision and impaired functional and associative knowledge. As a result, he could not access a complete semantic representation, required for activating phonological representations to name visually presented objects. The pattern of impairments and

  9. Effects of meteorological elements on admission rates of cerebral infarction patients with hypertensive nephropathy from nine hospitals in Changchun city, Jilin Province

    Institute of Scientific and Technical Information of China (English)

    YANG Bo-yu; ZHANG Yue; XU Chang-yan; JIA Bo-ting; WANG Chun-jie; JIA Zhan-jun; NI Hui

    2013-01-01

    Background It is well recognized that meteorological factors have important influences on the onset and development of many kinds of diseases.The present study was undertaken to investigate the effects of the meteorological elements on admission rates of cerebral infarction patients with hypertensive nephropathy at Changchun city,Jilin Province,northeast China.Methods A total of 763 medical records of inpatients from nine hospitals at Changchun city,during a period from April 6 to April 17 in 2010,were reviewed.These patients were admitted to hospitals due to the occurrence of cerebral infarction.The hypertensive nephropathy was evidenced with certain diagnosis of essential hypertension and hypertension-related kidney injuries.The cerebral infarction was diagnosed according to the World Health Organization (Stroke) standard.All the meteorological data were from practical monitoring records in Jilin Province Meteorological Observatory.The relationships between the epidemiological prevalence of cerebral infarction and meteorological variables were analyzed using the time series models of statistics.Results Compared with admission rates before the violent change in meteorological status (April 6 to April 17,2010),the number of admission patients suffering from cerebral infarction remarkably peaked on April 12.Such an increase was highly correlated with heavy precipitation,elevation of daily average relative humidity,and reduction of average daily air temperature.With the betterment of the meteorological conditions on April 17,the admission rates of cerebral infarction patients dropped to the same level as the dates before snowing (April 6 to April 11).Conclusions The meteorological changes are highly associated with the occurrence of cerebral infarction in patients with hypertensive renal injury in northeast China.This study also suggested that an intensive medical interference for those patients with hypertension-induced organ injuries is very necessary in preventing

  10. The follow-up research on the value of the plasma homocystine after methionine loading test on the recurrent ischemic vascular event in cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    刘怀翔

    2014-01-01

    Objective To evaluate the effect of the plasma homocystine(Hcy)after methionine loading test(MLT)on the recurrence of ischemic vascular event,including cerebral infarction,transient ischemic attack(TIA),acute coronary syndrome,other vascular embolism in cerebral infarction patients.Methods The fasting plasma homocystine(FHcy)and homocystine after MLT(PHcy)levels were measured by high-performance liquid chromatog-

  11. The therapeutic effect and prognosis of acute cerebral infarction patients with atrial fibrillation treated by intravenous thrombolysis with recombinant tissue plasminogen activator

    Institute of Scientific and Technical Information of China (English)

    尤寿江

    2013-01-01

    Objective To investigate the efficacy and safety of intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) in acute cerebral infarct patients with atrial fibrillation (AF) and the predicting factors of poor prognosis.Methods Totally 162 patients with acute cerebral infarct were treated with rt-PA within 4.5hours from the onset.According to past history and the electrocardiogram,the patients was classified into AF

  12. Stromal cell-derived factor-1α promotes angiogenesis in the peri-infarct region in adults with cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    凌莉

    2014-01-01

    Objective To investigate the possible effects of exogenous stromal cell-derived factor-1α(SDF-1α)on cell proliferation and angiogenesis in the ipsilateral thalamic ventroposterior nucleus(VPN)in adult rats with focal cortical infarction.Methods Thirty-six hypertensive rats with focal cortical infarction were divided randomly into the SDF-1αgroup,vehicle

  13. Characteristic analysis of secondary epileptic attack of senile arteriosclerotic cerebral infarction%老年人动脉硬化性脑梗死继发癫痫发作的特点分析

    Institute of Scientific and Technical Information of China (English)

    曹绪政; 兰杰; 徐建民; 邱朝晖

    2002-01-01

    Senile cerebral apoplexy is mainly caused by arteriosclerosis, which is also an important reason to epileptic attack. We analyzed clinical data of 1 383 in patient cerebral infarction cases from 211th Hospital of PLA from January 1996 to October 2001 in which there were 79 secondary epileptic attack of senile arteriosclerotic cerebral infarction.Results were shown followed.

  14. Does Preinterventional Flat-Panel Computer Tomography Pooled Blood Volume Mapping Predict Final Infarct Volume After Mechanical Thrombectomy in Acute Cerebral Artery Occlusion?

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    Wagner, Marlies, E-mail: marlies.wagner@kgu.de [Hospital of Goethe University, Institute of Neuroradiology (Germany); Kyriakou, Yiannis, E-mail: yiannis.kyriakou@siemens.com [Siemens AG, Health Care Sector (Germany); Mesnil de Rochemont, Richard du, E-mail: mesnil@em.uni-frankfurt.de [Hospital of Goethe University, Institute of Neuroradiology (Germany); Singer, Oliver C., E-mail: o.singer@em.uni-frankfurt.de [Hospital of Goethe University, Department of Neurology (Germany); Berkefeld, Joachim, E-mail: berkefeld@em.uni-frankfurt.de [Hospital of Goethe University, Institute of Neuroradiology (Germany)

    2013-08-01

    PurposeDecreased cerebral blood volume is known to be a predictor for final infarct volume in acute cerebral artery occlusion. To evaluate the predictability of final infarct volume in patients with acute occlusion of the middle cerebral artery (MCA) or the distal internal carotid artery (ICA) and successful endovascular recanalization, pooled blood volume (PBV) was measured using flat-panel detector computed tomography (FPD CT).Materials and MethodsTwenty patients with acute unilateral occlusion of the MCA or distal ACI without demarcated infarction, as proven by CT at admission, and successful Thrombolysis in cerebral infarction score (TICI 2b or 3) endovascular thrombectomy were included. Cerebral PBV maps were acquired from each patient immediately before endovascular thrombectomy. Twenty-four hours after recanalization, each patient underwent multislice CT to visualize final infarct volume. Extent of the areas of decreased PBV was compared with the final infarct volume proven by follow-up CT the next day.ResultsIn 15 of 20 patients, areas of distinct PBV decrease corresponded to final infarct volume. In 5 patients, areas of decreased PBV overestimated final extension of ischemia probably due to inappropriate timing of data acquisition and misery perfusion.ConclusionPBV mapping using FPD CT is a promising tool to predict areas of irrecoverable brain parenchyma in acute thromboembolic stroke. Further validation is necessary before routine use for decision making for interventional thrombectomy.

  15. Clinical effects of Xingnao Kaiqiao acupuncture on neurological impairment following cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Jie Xiong; Lina Ning; Jinling Bian; Jun Li; Junfeng Xu; Zhilong Zhang; Jiakui Guo; Yadong Li; Xuemin Shi

    2008-01-01

    BACKGROUND: Although the curative effects of acupuncture have been confirmed by various treatments of cerebral infarction, few studies have investigated when acupuncture can attain the best clinical effect.OBJECTIVE: Four different time points were selected for acupuncture treatment of cerebral infarction to evaluate the appropriate time course for Xingnao Kaiqiao therapy in terms of improved neurological function. DESIGN: Controlled observation.SETTING: Department of Traditional Chinese Medicine Rehabilitation and Physiotherapy of the Affiliated Hospital of Medical College of Chinese Armed Police Forces.PARTICIPANTS: A total of 120 inpatients with cerebral infarction of different stages, including 75 males and 45 females, aged 41-75 years, were selected from November 2005 to December 2006 at the Department of Traditional Chinese Medicine Rehabilitation and Physiotherapy in Affiliated Hospital of Medical College of Chinese Armed Police Forces. Diagnostic criteria: in accordance with "main points of diagnosis on different cerebrovascular disease" secondly revised in the Second Cerebrovascular Disease Academic Meeting of Chinese Medicine Association in 1986. All accepted subjects provided confirmed consent, and the experiment received ethical permission from the hospital's ethics committee.METHODS: ① Experiment grouping: All inpatients were divided into four groups with non-stochastic concurrent control method according to the disease course: Group I (onset within 7 hours), group Ⅱ (onset from 7 hours to 3 days), group Ⅲ (onset within 4-7 days), and group Ⅳ (onset within 21-180 days). On the basis of symptomatic treatment with western medicine, each group received Xingnao Kaiqiao therapy after onset within 7 hours, 7 hours to 3 days, 4 to 7days, and 21 to 180 days. ② The principal acupoints were Neiguan, Renzhong, and Sanyinjiao. ③ The auxiliary acupoints were Jiquan, Chize, and Weizhong. ④Acupuncture manipulations: initially, Neiguan (PC6, bilateral

  16. Correspondence of CT perfusion imaging to pathological manifestations in rabbit models of hyperacute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Mingwu Lou; Yi Fan; Lizhong Jia; Weidong Hu; Yan Teng; Guangfu Yang

    2007-01-01

    BACKGROUND: Could the infarction be diagnosed quickly and accurately at the acute stage by CT perfusion imaging (CTPI) technology? Whether the images of CTPI will correspond with the pathological changes or not? All the questions need to be solved by experimental and clinical studies.OBJECTIVE: To reveal the rules of perfusion map changes and guide the early diagnosis of hyperacute cerebral infarction by analyzing the correlation of CTPI with pathological manifestations for hyperacute cerebral infarction.DESIGN: A randomized controlled animal experiment.SETTING: Experimental Center of Medical Radiology, Longgang Central Hospital of Shenzhen City.MATERIALS: Forty-two adult New Zealand rabbits of (2.6±0.5) kg, either male or female, were randomly divided into experimental group (n =36) and control group (n =6). Six rabbits in the experimental group were observed after ischemia for 0.5, 1, 2, 3, 4 and 6 hours respectively, and 1 rabbit in the control group was observed at each corresponding time point.METHODS: The experiments were carded out in the Experimental Center of Medical Radiology,Longgang Central Hospital of Shenzhen City from March 2003 to July 2004, Rabbit models of cerebral scanned at 0.5, 1, 2, 3, 4 and 6 hours after ischemia respectively. The dynamic CT scan slice was 13 mm from the anterior edge of the frontal cortex, and six fake color functional images were obtained, including cerebral blood flow map (CBF map), cerebral blood volume map (CBV map), peak to enhancement map (PE map),flow without vessels map, time to peak map (TP map), time to start map (TS map). The manifestations and (ROI) were drawn separately on the CBF map, CBV map, TP map and TS map. The blood flow parameters of focal and contralateral cerebral tissues could be obtained to calculate relative cerebral blood flow (rCBF,rCBF=focal CBF/contralateral CBF), relative cerebral blood volume (rCBV, rCBV= focal CBV/contralateral CBV), a relative time to peak (rTP, rTP= focal TP

  17. Effect of "Phased Whole Acupuncture Therapy" on Ability of Daily Life in 63 Cases of Cerebral Infarction-induced Hemiplegia

    Institute of Scientific and Technical Information of China (English)

    Guo Yuanqi; Chen Liyi; Zhou Luojin; Li Hui; Qu Xuanming; Liu Dongsheng

    2006-01-01

    Objective: To observe the effect of "phased whole acupuncture therapy" on the ability of daily life (ADL)of the patients with cerebral infarction-induced hemiplegia. Methods: 113 patients were randomly divided into a treatment group (n=63) treated with phased whole acupuncture and a control group (n=50) treated with traditional acupuncture. After the treatment, the improvement of ADL was compared between the two groups. Results: Patients in the treatment group obtained satisfactory therapeutic effects in ADL improvement and in lowering of deformed rate, which were superior to those in the control group.Conclusion: The phased whole acupuncture is an effective therapy in treating cerebral infarction-induced hemlplegia, which can better improve the life quality of the patients.

  18. Cerebral infarction following intracranial hemorrhage in pediatric Moyamoya disease - A case report and brief review of literature

    Directory of Open Access Journals (Sweden)

    Soumya Patra

    2012-01-01

    Full Text Available Moyamoya disease is a clinical entity characterized by progressive cerebrovascular occlusion with spontaneous development of a collateral vascular network called Moyamoya vessels. This disease mainly manifests as cerebral ischemia. Intracranial bleeding is another major presentation of patients with Moyamoya disease. We report here a 12-year-old male child who presented with severe headache, vomiting and meningismus. Initial neuroimaging study with noncontrast computed tomography scan revealed fresh intraventricular hemorrhage in right-sided lateral ventricle. Magnetic resonance imaging with angiography of brain was done 5 days later when the child developed right-sided hemiparesis, and the diagnosis of Moyamoya disease was confirmed along with lacunar infarction of right posterior peri and paraventricular area and in the left paraventricular area and centrum semiovale. Simultaneous presence of cerebral infarction along with intraventricular hemorrhage in adult with bleeding-type Moyamoya disease is reported in literature, but it is a rare entity in a child.

  19. Correlating plasma endothelin-1 and beta-endorphin levels to nine risk factors of acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Daoyou Zhou; Jun Liu; Yingrong Lao; Yigang Xing; Yan Huang

    2008-01-01

    BACKGROUND:Several studies have confirmed that endothelin and endorphin are involved in the occurrence of cerebral vasospasm. However, the correlation of these factors to acute cerebral infarction-related risk factors needs to be confirmed.OBJECTIVE:To detect endothelin-1(ET-1)and beta-endorphin(β-EP)levels in plasma of patients with acute cerebral infarction,and to analyze the correlations of these factors to smoking,alcohol abuse, hypertension,diabetes mellitus,diseased region,diseased degree,gender,and other factors related to acute cerebral infarction. DESIGN:A case-control observation. SETTING:First Department of Neurology,Guangdong Hospital of Traditional Chinese Medicine; Department of Neurology,Second Affiliated Hospital of Sun Yat-sen University.PARTICIPANTS:Sixty-nine inpatients with acute cerebral infarction were admitted to the Department of Neurology,Second Affiliated Hospital of Sun Yat-sen University(March 2003-January 2004)and First Department of Neurology,Guangdong Hospital of Traditional Chinese Medicine(March - July 2004)and recruited for this study.All 69 inpatients corresponded to the diagnosis criteria of acute cerebral infarction,formulated in the National Working Conference of Cerebrovascular Disease in 1998,and were confirmed as acute cerebral infarction by CT/MRI.The patient group consisted of 35 males [(64±12)years old] and 34 females[(67±13 )years old].Among them,9 patients were smokers,7 were alcohol users,48 had a history of hypertension,and 16 had a history of diabetes mellitus.CT/MRI examinations revealed that 35 patients presented with left focus sites,11 with right ones and 23 with bilateral ones.Following attack,24 patients had Barthel Index Scale grading<40 points,21 patients 40-60 points,and 24 patients>60 points.An additional 59 healthy individuals,who received health examinations simultaneously,were included as controls.Among the control subjects,there were 37 males [(62±10)years old] and 22 females [(65±11) years old

  20. Anesthesia-Induced Hypothermia Attenuates Early-Phase Blood-Brain Barrier Disruption but Not Infarct Volume following Cerebral Ischemia.

    Science.gov (United States)

    Liu, Yu-Cheng; Lee, Yu-Da; Wang, Hwai-Lee; Liao, Kate Hsiurong; Chen, Kuen-Bao; Poon, Kin-Shing; Pan, Yu-Ling; Lai, Ted Weita

    2017-01-01

    Blood-brain barrier (BBB) disruption is thought to facilitate the development of cerebral infarction after a stroke. In a typical stroke model (such as the one used in this study), the early phase of BBB disruption reaches a peak 6 h post-ischemia and largely recovers after 8-24 h, whereas the late phase of BBB disruption begins 48-58 h post-ischemia. Because cerebral infarct develops within 24 h after the onset of ischemia, and several therapeutic agents have been shown to reduce the infarct volume when administered at 6 h post-ischemia, we hypothesized that attenuating BBB disruption at its peak (6 h post-ischemia) can also decrease the infarct volume measured at 24 h. We used a mouse stroke model obtained by combining 120 min of distal middle cerebral arterial occlusion (dMCAo) with ipsilateral common carotid arterial occlusion (CCAo). This model produced the most reliable BBB disruption and cerebral infarction compared to other models characterized by a shorter duration of ischemia or obtained with dMCAO or CCAo alone. The BBB permeability was measured by quantifying Evans blue dye (EBD) extravasation, as this tracer has been shown to be more sensitive for the detection of early-phase BBB disruption compared to other intravascular tracers that are more appropriate for detecting late-phase BBB disruption. We showed that a 1 h-long treatment with isoflurane-anesthesia induced marked hypothermia and attenuated the peak of BBB disruption when administered 6 h after the onset of dMCAo/CCAo-induced ischemia. We also demonstrated that the inhibitory effect of isoflurane was hypothermia-dependent because the same treatment had no effect on ischemic BBB disruption when the mouse body temperature was maintained at 37°C. Importantly, inhibiting the peak of BBB disruption by hypothermia had no effect on the volume of brain infarct 24 h post-ischemia. In conclusion, inhibiting the peak of BBB disruption is not an effective neuroprotective strategy, especially in comparison

  1. Quantification of infarct size on focal cerebral ischemia model of rats using a simple and economical method.

    Science.gov (United States)

    Yang, Y; Shuaib, A; Li, Q

    1998-10-01

    Quantification of infarct size is a very useful index to assess models of focal cerebral ischemia and effects of new therapies. Currently-used image analysis systems to carry out this task usually involve dedicated and expensive equipment. We present a low-cost and simple method to perform the image acquisition and analysis. Twelve Wistar rats were subject to focal cerebral ischemia and scarified 24 h after the insult. 2,3,5-triphenyl tetrazolium chloride (TTC) stain was used as a conventional method to differentiate ischemic damage from healthy brain tissue. Digital images were captured from the stained coronal sections using a flatbed color scanner and analyzed with a commercial image processing software. To evaluate the accuracy and reproducibility of this method, the data obtained with the current procedure was correlated with those from a dedicated standard image analysis system and intra-observor correlation coefficient was estimated. Also the sensitivity of this method in quantification of infarct volume was tested in two different experimental settings. There was close correlation in the outcome of infarct size measurement between the current method and the standard system (r = 0.93, p < 0.001). A high agreement of measurement of the percentage of infarct volume between two different examiners with the same source of samples (r = 0.98, p < 0.001). We demonstrated that this method was sensitive in detection of difference of infarct sizes when placebo-treated animals (n = 6) were compared to the group treated with a neuroprotective agent (n = 6). Our data demonstrated that ischemic lesion of focal cerebral ischemia in rat can be accurately and reproducibly quantified using this method. The low-cost and simplicity of this method may facilitate the application in determination of ischemic damage.

  2. EFFECT OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION ON CEREBRAL HEMODYNAMICS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION (THE RESULTS OF OBSERVATIONAL STUDIES

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    V. E. Kulikov

    2015-12-01

    Full Text Available Aim. To study the effect of left ventricular (LV systolic dysfunction on cerebral hemodynamic in patients with ST segment elevation myocardial infarction (STEMI during acute period. Material and methods. Cerebral hemodynamics ultrasound assessment was performed in the extra-and intracranial vessels in 118 patients with STEMI. Results. Significant changes in cerebral hemodynamics were found in LV systolic dysfunction with ejection fraction (LVEF ≤40% due to hemispheric blood flow asymmetry in the middle cerebral artery (MCA as large as 45.1±6.7% with correlation coefficient r=-0.87. Compensation of cerebral blood flow was manifested in vasoconstriction or vasodilation (resistive index 0.63-0.76 and 0.49-0.43 c.u., respectively. Conclusion. A strong relationship between LV systolic dysfunction and cerebral hemodynamic was found in patients with STEMI. It was manifested in significant contralateral hemispheric blood flow asymmetry in MCA in patients with LVEF ≤40%. Reduction in cerebral blood flow velocity activated autoregulation mechanism in the form of vasoconstriction or vasodilation.

  3. Association of serum immunoglobulin-G to Porphyromonas gingivalis with acute cerebral infarction in the Chinese population

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    Zhang Zheng

    2015-01-01

    Full Text Available Background/Purpose: There is evidence supporting an association between ischemic stroke and periodontitis in western countries. Differing genetic backgrounds and lifestyles among populations may affect this association. The aim of our study was to determine whether antibody titers to Porphyromonas gingivalis are associated with acute cerebral infarction in the Chinese population. Materials and Methods: This case-control study was conducted on 88 acute cerebral infarction patients and 40 healthy control subjects. Serum immunoglobulin-G (IgG antibody to P. gingivalis was analyzed by enzyme-linked immune sorbent assay. Serum lipids were determined with the automatic biochemical analyzer. Fibrinogen was measured using automated coagulation analyzer. High-sensitivity C-reactive protein (hs-CRP and interleukin-6 (IL-6 were quantified using commercial ELISA kits. The intima-media thickness of the common carotid arteries (IMT-CCA was measured by ultrasonography. Results: The results showed that P. gingivalis IgG antibody levels were significantly higher in acute cerebral infarction cases than in healthy controls (mean ± standard deviation, 11.06 ± 1.49 vs. 9.15 ± 1.70, P < 0.001. There were significant correlations of P. gingivalis IgG titer with total cholesterol (r = 0.34, P = 0.001, low-density lipoprotein (r = 0.39, P < 0.001, apolipoprotein-B (r = 0.30, P = 0.004, hs-CRP (r = 0.35, P = 0.001, IL-6 (r = 0.27, P = 0.011, and IMT-CCA (left: r = 0.306, P = 0.004; right: r = 0.241, P = 0.024. Conclusion: Antibody titers to P. gingivalis are associated with acute cerebral infarction in the Chinese population.

  4. Inhibition of Cathepsin B Alleviates Secondary Degeneration in Ipsilateral Thalamus After Focal Cerebral Infarction in Adult Rats.

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    Zuo, Xialin; Hou, Qinghua; Jin, Jizi; Zhan, Lixuan; Li, Xinyu; Sun, Weiwen; Lin, Kunqin; Xu, En

    2016-09-01

    Secondary degeneration in areas beyond ischemic foci can inhibit poststroke recovery. The cysteine protease Cathepsin B (CathB) regulates cell death and intracellular protein catabolism. To investigate the roles of CathB in the development of secondary degeneration in the ventroposterior nucleus (VPN) of the ipsilateral thalamus after focal cerebral infarction, infarct volumes, immunohistochemistry and immunofluorescence, and Western blotting analyses were conducted in a distal middle cerebral artery occlusion (dMCAO) stroke model in adult rats. We observed marked neuron loss and gliosis in the ipsilateral thalamus after dMCAO, and the expression of CathB and cleaved caspase-3 in the VPN was significantly upregulated; glial cells were the major source of CathB. Although it had no effect on infarct volume, delayed intracerebroventricular treatment with the membrane-permeable CathB inhibitor CA-074Me suppressed the expression of CathB and cleaved caspase-3 in ipsilateral VPN and accordingly alleviated the secondary degeneration. These data indicate that CathB mediates a novel mechanism of secondary degeneration in the VPN of the ipsilateral thalamus after focal cortical infarction and suggest that CathB might be a therapeutic target for the prevention of secondary degeneration in patients after stroke.

  5. Rehabilitation Nursing for Patients with Cerebral Infarction%脑梗死患者的康复护理

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    吴小园

    2014-01-01

    目的:康复护理方法将脑梗塞偏瘫患者肢体。方法对我院收治的46例脑梗死患者,给予偏瘫康复护理方法,并在入院和出院时给予强度试验,对比变化之前和之后的肌肉强度。结果肌力测验提高,出院较入院差异有显著性(P<0.05)。结论康复训练对脑梗死偏瘫患者肢体的实施,对肌力恢复的更好的效果,可以帮助患者树立战胜疾病的信心。%Objective Rehabilitation nursing method to introduce the cerebral infarction limbs in hemiplegic patients. Methods 46 cases of cerebral infarction patients in our hospital, give the hemiplegic rehabilitation nursing methods, and to give strength test at admission and discharge, the situation changes before and after the muscle strength. Results The discharge strength test and admission strength has improved, the dif erence was significant ( <0.05). Conclusion The implementation of systematic rehabilitation training on cerebral infarction hemiplegia patients limbs, has a bet er ef ect on the recovery of myodynamia, can help patients to establish the confidence to overcome the disease.

  6. Major ozonated autohemotherapy promotes the recovery of upper limb motor function in patients with acute cerebral infarction

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    Xiaona Wu; Zhensheng Li; Xiaoyan Liu; Haiyan Peng; Yongjun Huang; Gaoquan Luo; Kairun Peng

    2013-01-01

    Major ozonated autohemotherapy is classically used in treating ischemic disorder of the lower limbs. In the present study, we performed major ozonated autohemotherapy treatment in patients with acute cerebral infarction, and assessed outcomes according to the U.S. National Institutes of Health Stroke Score, Modified Rankin Scale, and transcranial magnetic stimulation motor-evoked potential. Compared with the control group, the clinical total effective rate and the cortical potential rise rate of the upper limbs were significantly higher, the central motor conduction time of upper limb was significantly shorter, and the upper limb motor-evoked potential amplitude was significantly increased, in the ozone group. In the ozone group, the National Institutes of Health Stroke Score was positively correlated with the central motor conduction time and the motor-evoked potential amplitude of the upper limb. Central motor conduction time and motor-evoked potential amplitude of the upper limb may be effective indicators of motor-evoked potentials to assess upper limb motor function in cerebral infarct patients. Furthermore, major ozonated autohemotherapy may promote motor function recovery of the upper limb in patients with acute cerebral infarction.

  7. Effect of Herbal Prescriptions in Accordance with Pattern Identification in Acute Cerebral Infarction Patients: Based on Fire-Heat Pattern

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    WooSang Jung

    2015-01-01

    Full Text Available Objectives. This study was conducted to verify the necessity of corresponding prescription to the diagnosed pattern in acute cerebral infarction patients. Methods. We studied cerebral infarction patients hospitalized within 30 days after the ictus. Forty-four clinical indicators, Motricity Index (MI score, Scandinavian Stroke Scale (SSS score, and herbal prescriptions were checked twice, two weeks apart. The probability of each pattern was calculated based on the clinical indicators. Changes in MI score, SSS score, and the probability of fire-heat pattern were compared between the pattern-prescription correspondence group and the noncorrespondence group. Results. Increments of MI score and SSS score in the correspondence group were significantly greater than those of the noncorrespondence group (p=0.003, p=0.001 while the baseline score of the two groups showed no significant difference. Probability of fire-heat pattern decreased significantly in the correspondence group (p=0.013 while the noncorrespondence group showed no significant difference after the treatment. Conclusion. Acute cerebral infarction patients who are diagnosed as fire-heat pattern showed better improvement in dysfunctions caused by the disease when they took the pattern corresponding prescriptions. This study provides evidence for the necessity and usefulness of pattern identification in Traditional Korean Medicine.

  8. Outcome after decompressive craniectomy in patients with dominant middle cerebral artery infarction: A preliminary report

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    Amandeep Kumar

    2013-01-01

    Full Text Available Introduction: Life-threatening, space occupying, infarction develops in 10-15% of patients after middle cerebral artery infarction (MCAI. Though decompressive craniectomy (DC is now standard of care in patients with non-dominant stroke, its role in dominant MCAI (DMCAI is largely undefined. This may reflect the ethical dilemma of saving life of a patient who may then remain hemiplegic and dysphasic. This study specifically addresses this issue. Materials and Methods: This retrospective analysis studied patients with DMCAI undergoing DC. Patient records, operation notes, radiology, and out-patient files were scrutinized to collate data. Glasgow outcome scale (GOS, Barthel index (BI and improvement in language and motor function were evaluated to determine functional outcome. Results: Eighteen patients between 22 years and 72 years of age were included. 6 week, 3 month, 6 month and overall survival rates were 66.6% (12/18, 64% (11/17, 62.5% (10/16 and 62.5% (10/16 respectively. Amongst ten surviving patients with long-term follow-up, 60% showed improvement in GOS, 70% achieved BI score >60 while 30% achieved full functional independence. In this group, motor power and language function improved in 9 and 8 patients respectively. At last follow-up, 8 of 10 surviving patients were ambulatory with (3/8 or without (5/8 support. Age <50 years corresponded with better functional outcome amongst survivors (P value -0.0068. Conclusion: Language and motor outcomes after DC in patients with DMCAI are not as dismal as commonly perceived. Perhaps young patients (<50 years with DMCAI should be treated with the same aggressiveness that non-DMCAI is currently dealt with.

  9. Visual agnosia and posterior cerebral artery infarcts: an anatomical-clinical study.

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    Olivier Martinaud

    Full Text Available BACKGROUND: To evaluate systematically the cognitive deficits following posterior cerebral artery (PCA strokes, especially agnosic visual disorders, and to study anatomical-clinical correlations. METHODS AND FINDINGS: We investigated 31 patients at the chronic stage (mean duration of 29.1 months post infarct with standardized cognitive tests. New experimental tests were used to assess visual impairments for words, faces, houses, and objects. Forty-one healthy subjects participated as controls. Brain lesions were normalized, combined, and related to occipitotemporal areas responsive to specific visual categories, including words (VWFA, faces (FFA and OFA, houses (PPA and common objects (LOC. Lesions were located in the left hemisphere in 15 patients, in the right in 13, and bilaterally in 3. Visual field defects were found in 23 patients. Twenty patients had a visual disorder in at least one of the experimental tests (9 with faces, 10 with houses, 7 with phones, 3 with words. Six patients had a deficit just for a single category of stimulus. The regions of maximum overlap of brain lesions associated with a deficit for a given category of stimuli were contiguous to the peaks of the corresponding functional areas as identified in normal subjects. However, the strength of anatomical-clinical correlations was greater for words than for faces or houses, probably due to the stronger lateralization of the VWFA, as compared to the FFA or the PPA. CONCLUSIONS: Agnosic visual disorders following PCA infarcts are more frequent than previously reported. Dedicated batteries of tests, such as those developed here, are required to identify such deficits, which may escape clinical notice. The spatial relationships of lesions and of regions activated in normal subjects predict the nature of the deficits, although individual variability and bilaterally represented systems may blur those correlations.

  10. 脑分水岭梗死与脑血管狭窄类型相关性研究%Relationship between cerebral watershed infarction and cerebral vessels

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    刘淑琴

    2012-01-01

    目的 针对脑分水岭梗死(CWI)与脑血管狭窄类型的相关性进行统计分析.方法 对我院从2005年3月至2010年9月收治的128例脑分水岭梗死病患与同期收治的128例非脑分水岭梗死病患行头颅CT和核磁共振MRI检查,并应用头颅多普勒(TCD)检测颅内血管与脑血管造影DSA显示脑血管,统计分析影像结果.结果 128例脑分水岭梗死病患与颈内动脉与脑内动脉狭窄有一定的相关性(P<0.05),其中大脑前动脉狭窄42例(32.8%),大脑中动脉狭窄78例(60.9%),大脑后动脉狭窄36例(28.1%),大脑基底动脉狭窄49例(38.3%),颈内动脉狭窄85例(66.4%),差异有统计学意义(P<0.05).结论 脑分水岭梗死与颈内动脉和脑内动脉狭窄有一定的相关性,其中,与颈内动脉和大脑中动脉狭窄关系密切,值得深入研究和讨论.%Objective To analyze the relationship between cerebral watershed infarction ( CWI )and the types of stenosis of cerebral vessels.Methods 128 patients with CWI and 128 patients with other types of cerebral infarction who had been hospitalized during the period of March 2005 to September 2010were detected by cranial CT and MRI.TCD and DSA were used to examine cerebral vessels.The imaging findings were analyzed.Results In 128 patients,cerebral watershed infarction was related with internal carotid artery stenosis and internal cerebral arteriostenosis ( P< 0.05 ).42( 32.8% )patients were stenosis of precerebral artery stenosis,78( 60.9% ) were stenosis of middle cerebral artery,36 ( 28.1% ) were stenosis of postcerebral artery,49( 38.3% ) were basilar artery stenosis,and 85( 66.4% ) were internal cerebral arteriostenosis,with statistical differences ( P < 0.05 ).Conclusions Cerebral watershed infarction has certain relationship with internal carotid artery stenosis and internal cerebral arteriostenosis,especially with internal carotid artery stenosis and middle cerebral artery stenosis.It is worth further

  11. The preliminary study of Ultraviolet-Irradiated and Oxygenated Blood Transfusion Therapy(UOBT) for Experimental Cerebral Infarction of Animal Brain Model

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    Su Xiu-Chu; Feng You-Qi; Zhou gang; Wu jun-yi

    2000-01-01

    In this presented study, we have developed a photochemical model of cerebral in farction in rabbit with stable and reproducible infarct size and extent. This model is similar to the pathological changes in human cerebral infarction. Using this model, therapeutic effects and mechanisms of UOBT on brain ischemic injury were invetigated in rabbits following the photochemical infarcnon The results showed that UOBT could significantly reduce the mtarcted size, and improve the cerebral blood flow compared with the control animals treated with non-u-radiated ad non-oxygenated blood transfusion. These data suggest that the UOBT may have a therapeutic potential for clinical rehabilitation effect in stroke treatment

  12. Risk of Cerebral Infarction in Japanese Hemodialysis Patients: Miyazaki Dialysis Cohort Study (MID study

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    Tatsunori Toida

    2016-07-01

    Full Text Available Background/Aims: Predictors including the preventive effects of antiplatelet and anticoagulant drugs on cerebral infarction (CI events have not yet been clarified in dialysis patients. The aim of the present study was to examine the risk of CI and preventive effects of these drugs in Japanese hemodialysis patients. Methods: Patients receiving maintenance hemodialysis (n=1,551, median age (interquartile range, 69.0 (59.0-78.0 years; 41.5% female were enrolled in the Miyazaki Dialysis Cohort Study and prospectively followed-up for 3 years. Kaplan-Meier and Cox's regression analyses were used to clarify the risk of CI. Results: Eighty-four patients developed CI at an incidence of 21.5/1000 patients per year. The presence of a previous history of CI, atrial fibrillation (AF, and diabetes mellitus in addition to age were also identified as predictive factors for new CI, whereas no relationship was observed between antiplatelet and/or anticoagulant usage and CI. Furthermore, no significant difference was noted in the frequency of CI events between patients with AF who received warfarin and those who did not. Conclusions: The incidence of CI was higher in dialysis patients with a previous history of CI and AF; however, the preventive effects of antiplatelet/anticoagulant drugs on the development of CI were not evident.

  13. Changes of serum high sensitive C-reactive protein in patients with acute cerebral infarction

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    Yan Du; Yan Ren; Ying Li

    2007-01-01

    BACKGROUND: Serum high sensitive C-reactive protein (hs-CRP), which regards as a high sensitive mark of systemic inflammatory response syndrome, can provide a lot of valuable information for the treatment and prognosis of cerebrovascular disease.OBJECTIVE: To observe the differences of blood glucose, lipid, homocysteine and previous disease history among patients with acute cerebral infarction at various levels of hs-CRP and compare changes of hs-CRP of patients with various degrees ofneurologic impairment.DESIGN: Contrast observation.SETTING: Department of Neurology, Shenzhou Hospital, Shenyang Medical College.PARTICIPANTS: A total of 102 patients with acute cerebral infarction were selected from Department of Neurology, Shenzhou Hospital of Shenyang Medical College from February 2005 to September 2006,including 55 males and 47 females aged from 55 to 86 years. All accepted patients met the diagnostic criteria of cerebral infarction established by the Fourth National Cerebrovascular Disease Academic Meeting and were diagnosed with CT or MRI examination. All patients provided the confirmed consent. Based on clinical criteria of neurologic impairment established by the Fourth National Cerebrovascular Disease Academic Meeting, patients were randomly divided into mild group (0- 15 points, n =46), moderate group (16- 30points, n =38) and severe group (31 - 45 points, n =18). In addition, based on hs-CRP level within 72 hours,patients were divided into normal group (hs-CRP ≤ 3 mg/L, n =53) and increasing group (hs-CRP > 3 mg/L,n =49).METHODS: ① 2 mL venous blood was selected from hospitalized patients in the next morning to separate serum. Quantitative measurement of hs-CRP was dealt with Latex Enhnced Turbidimetric Immunoassay (LETIA). ② Fasting venous blood was colleted from hospitalized patients in the next morning to measure numeration of white blood cells, fibrinogen, blood glucose, total cholesterol (TC), triacylglycerol (TG), high density lipoprotein

  14. The effect of Jeo Dang-Tang on cytokines production in the patients with cerebral infarction.

    Science.gov (United States)

    Jeong, Hyun-Ja; Kang, Sei-Young; Kim, Sang-Yong; Lee, Sang-Gwan; Lee, Sung-Geun; Sung, Kang-Keyng; Kim, Hyung-Min

    2003-11-01

    The herbal formulation "Jeo Dang-Tang" (JDT) has long been used for various cerebrovascular diseases. However, very little has scientific investigation been carried out. The aim of the present study is to investigate the effect of JDT on the production of various cytokines in the patients with cerebral infarction (CI). Peripheral blood mononuclear cells (PBMC) obtained from the patients with CI were cultured for 24h in the presence or absence of lipopolysaccharide (LPS) or phytohemagglutinin (PHA). The amount of interleukin (IL)-4, IL-10 and transforming growth factor (TGF)-1beta, in culture supernatant, was significantly increased in the JDT, LPS or PHA treated cells compared to unstimulated cells (P < 0.05). We also show that increased IL-4, and IL-10 level by LPS or PHA was significantly inhibited by JDT in a dose-dependent manner. Maximal inhibition rate of IL-4 and IL-10 production by JDT was 45 +/- 2% and 51 +/- 5% for LPS-stimulated cell and 41.5 +/- 3% and 70.8 +/- 2% for PHA-stimulated cells, respectively (P < 0.05). On the other hand, JDT significantly increased the LPS or PHA-induced TGF-beta1 production (P < 0.05). These data suggest that JDT has a regulatory effect on the cytokines production, which might explain its beneficial effect in the treatment of CI.

  15. A meta-analysis of relationship between β-fibrinogen gene -148C/T polymorphism and susceptibility to cerebral infarction in Han Chinese

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    CHEN Xiao-chao; XU Ming-tong; ZHOU Wu; HAN Chun-li; CHEN Wei-qing

    2007-01-01

    Objective The results of studies on association between -148C/T polymorphism in promoter region of β-fibrinogen gene and susceptibility to cerebral infarction in Chinese population are controversial. In this study, we summarize the results of published works in this field by a meta-analysis.Data sources Genetic association studies evaluating the β-fibrinogen gene -148C/T polymorphisms and cerebral infarction involving Chinese population published before December 2005 were collected from PubMed, EMBASE and CNKI.Study selection Case control studies involving unrelated, Han subjects aged from 18 to 80 years, and the internationally recognized diagnostic standard of cerebral infarction and genotype frequencies in control group consistent with Hardy-Weinberg equilibrium were used. Publication bias was tested by funnel plot and the odds ratios of all studies were combined dependent on the result of heterogeneity test among the individual studies. The software Review Manager (Version 4.2) was used for meta-analysis.Results Eleven studies including 1223 patients and 1433 controls met the selection criteria. There was no heterogeneity among the odds ratios (ORs) of individual studies (x2=17.82, P=0.06). The combined OR of susceptibility to cerebral infarction in -148T allele carriers compared to the wild homozygote was 1.32 (95%C/1.12 to 1.55, P=0.0008).In the patients with cerebral infarction, the average plasma fibrinogen level of allele T carrier was 0.42 g/L (95%CI 0.29 to 0.54, P<0.001), higher than that of -148C/C homozygous ones.Conclusions β-fibrinogen gene -148C/T polymorphism might contribute to susceptibility to cerebral infarction in Han Chinese. To reach a definitive conclusion, further gene to gene and gene to environment interactions studies on β-fibrinogen polymorphisms and cerebral infarction with large sample size are required.

  16. Early magnetic resonance detection of cortical necrosis and acute network injury associated with neonatal and infantile cerebral infarction

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    Okabe, Tetsuhiko; Aida, Noriko; Nozawa, Kumiko [Kanagawa Children' s Medical Center, Department of Radiology, Yokohama (Japan); Niwa, Tetsu [Kanagawa Children' s Medical Center, Department of Radiology, Yokohama (Japan); Tokai University School of Medicine, Department of Radiology, Isehara (Japan); Shibasaki, Jun [Kanagawa Children' s Medical Center, Department of Neonatology, Yokohama (Japan); Osaka, Hitoshi [Kanagawa Children' s Medical Center, Department of Neurology, Yokohama (Japan)

    2014-05-15

    Knowledge of MRI findings in pediatric cerebral infarction is limited. To determine whether cortical necrosis and network injury appear in the acute phase in post-stroke children and to identify anatomical location of acute network injury and the ages at which these phenomena are seen. Images from 12 children (age range: 0-9 years; neonates [<1 month], n=5; infants [1 month-12 months], n=3; others [≥1 year], n=4) with acute middle cerebral artery (MCA) cortical infarction were retrospectively analyzed. Cortical necrosis was defined as hyperintense cortical lesions on T1-weighted imaging that lacked evidence of hemorrhage. Acute network injury was defined as hyperintense lesions on diffusion-weighted imaging that were not in the MCA territory and had fiber connections with the affected cerebral cortex. MRI was performed within the first week after disease onset. Cortical necrosis was only found in three neonates. Acute network injury was seen in the corticospinal tract (CST), thalamus and corpus callosum. Acute network injury along the CST was found in five neonates and one 7-month-old infant. Acute network injury was evident in the thalamus of four neonates and two infants (ages 4 and 7 months) and in the corpus callosum of five neonates and two infants (ages 4 and 7 months). The entire thalamus was involved in three children when infarction of MCA was complete. In acute MCA cortical infarction, MRI findings indicating cortical necrosis or acute network injury was frequently found in neonates and early infants. Response to injury in a developing brain may be faster than that in a mature one. (orig.)

  17. Effect of Panaxtriol Saponins on synaptophysin and postsynaptic density-95 expression at different periods of cerebral infarction

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    Fangyuan Cui; Jiangying Zhai; Weimeng Zou; Xiling Wang; Yihuai Zou; Linggqun Zhu

    2008-01-01

    BACKGROUND: The change in expression of synaptophysin (Syp) and postsynaptic density-95 (PSD-95) alters after cerebral infarction, and the plasticity of synapses contributes greatly to nerve function recovery. Chinese medicinal substances may play an important role in the expression of Syp and PSD-95. OBJECTIVE: To observe the effect of Panaxtriol Saponins (PTS), an active component in Sanqi tongshu capsules, on the expression of Syp and PSD-95 after cerebral infarction at different time points in rats, so as to examine the cerebral function remodeling mechanism. DESIGN, TIME AND SETTING: A randomized and controlled observation which was performed in Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine from January to March, 2007. MATERIALS: Twenty-six healthy male Sprague Dawley rats were used to establish middle cerebral artery occlusion based on the Longa method. Sanqi tongshu capsules (containing 100 mg PTS per tablet) were provided by the Chengdu Huashen Group and nimodipine tablets (30 mg) by Tianjin Zhongyang Pharmaceutical Co., Ltd. METHODS: Twenty-six rats were randomly divided into an operation group (n = 21) and a control group (n = 5). The operation group underwent the EZ Longa procedure to make the middle cerebral artery occlusion model. After surgery rats were randomly divided into a model group, a PTS group and a nimodipine group, with seven rats in each group. Rats were intragastrically administrated with saline (2 mL/d) in the model group, with Sanqi tongshu capsule (5.4 mg/100 g/d) in the PTS group, and with nimodipine (1.73 mg/100 g/d) in the nimodipine group. Rats in the control group did not undergo model establishment and drug administration. MAIN OUTCOME MEASURES: The expressions of Syp and PSD-95 were measured by immunohistochemical and image analysis at days 3, 7 and 28 after the operation. RESULTS: The expression of Syp and PSD-95 in the operation group was significantly lower than in the control group at days 3, 7, 28

  18. Recurrent cerebral venous infarcts and superior vena cava obstruction: case report

    Energy Technology Data Exchange (ETDEWEB)

    Bozzao, A. [Department of Radiology, University of Rome ``Tor Vergata``, Rome (Italy)]|[Istituto di Radiologia, Ospedale S. Eugenio, Piazzale dell`Umanesimo 10 I-00144 Roma (Italy); Gallucci, M. [Department of Neuroradiology, University of L`Aquila, L`Aquila (Italy); Marsili, L. [Department of Neuroradiology, University of L`Aquila, L`Aquila (Italy); Cerone, G. [Department of Neurology, Collemaggio Hospital, L`Aquila (Italy)

    1997-06-01

    We report a patient with repeated venous infarcts in the occipital lobe and occlusion of the superior vena cava. The pathogenetic relationships between the superior vena cava occlusion and the brain infarcts are discussed. High pressure in the superior venous territory and incomplete patency of the transverse sinus are probably responsible for the venous infarcts. (orig.). With 4 figs.

  19. Functional electrical stimulation-facilitated proliferation and regeneration of neural precursor cells in the brains of rats with cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Yun Xiang; Huihua Liu; Tiebin Yan; Zhiqiang Zhuang; Dongmei Jin; Yuan Peng

    2014-01-01

    Previous studies have shown that proliferation of endogenous neural precursor cells cannot alone compensate for the damage to neurons and axons. From the perspective of neural plastici-ty, we observed the effects of functional electrical stimulation treatment on endogenous neural precursor cell proliferation and expression of basic fibroblast growth factor and epidermal growth factor in the rat brain on the infarct side. Functional electrical stimulation was performed in rat models of acute middle cerebral artery occlusion. Simultaneously, we set up a placebo stimulation group and a sham-operated group. Immunohistochemical staining showed that, at 7 and 14 days, compared with the placebo group, the numbers of nestin (a neural precursor cell marker)-positive cells in the subgranular zone and subventricular zone were increased in the functional electrical stimulation treatment group. Western blot assays and reverse-transcription PCR showed that total protein levels and gene expression of epidermal growth factor and basic ifbroblast growth factor were also upregulated on the infarct side. Prehensile traction test results showed that, at 14 days, prehension function of rats in the functional electrical stimulation group was signiifcantly better than in the placebo group. These results suggest that functional electrical stimulation can promote endogenous neural precursor cell proliferation in the brains of acute cerebral infarction rats, enhance expression of basic fibroblast growth factor and epidermal growth factor, and improve the motor function of rats.

  20. Assessment value of transcranial Doppler hemodynamic typing for prognosis of patients with acute middle cerebral artery infarction

    Institute of Scientific and Technical Information of China (English)

    Jing Xie

    2016-01-01

    Objective:To analyze the assessment value of transcranial Doppler hemodynamic typing for prognosis of patients with acute middle cerebral artery infarction.Methods:A total of 54 cases of patients with acute middle cerebral artery infarction who received treatment in our hospital from January 2014 to June 2015 were included for study, and according to different types, they were divided into total occlusion group 17 cases, partial occlusion group 28 cases and non-occlusion group 9 cases. Differences in levels of infarction-related proteins, coagulation-related indicators, illness-related factors, etc in circulating blood of three groups were compared, and the correlation of middle cerebral arterial systolic velocity (Vs) and diastolic velocity (Vd) with above indicators was further analyzed.Results:Vs and Vd values of non-occlusion group were higher than those of total occlusion group and partial occlusion group, and Vs and Vd values of partial occlusion group were higher than those of total occlusion group; serum Gelsolin, PT, APTT and TT values of non-occlusion group were higher, SAA, Apo- CⅡ, HbA1c, GSP, Aβ, HSP70, FIB, D-D, Copeptin, P-selectin, PTX3, TPO and FFA values were lower, and compared with partial occlusion group and total occlusion group, differences were significant; Gelsolin, PT, APTT and TT values of partial occlusion group were higher than those of total occlusion group, and SAA, Apo- CⅡ, HbA1c, GSP, Aβ, HSP70, FIB, D-D, Copeptin, P-selectin, PTX3, TPO and FFA values were lower than those of total occlusion group; middle cerebral arterial Vs and Vd values were directly proportional to Gelsolin, PT, APTT and TT values, and inversely proportional to SAA, Apo- CⅡ, HbA1c, GSP, Aβ, HSP70, FIB, D-D, Copeptin, P-selectin, PTX3, TPO and FFA values.Conclusions:Transcranial Doppler hemodynamic typing can be the reliable way to judge the severity of acute middle cerebral artery infarction, and has great value in assessing disease prognosis.

  1. Fullerenols and glucosamine fullerenes reduce infarct volume and cerebral inflammation after ischemic stroke in normotensive and hypertensive rats.

    Science.gov (United States)

    Fluri, Felix; Grünstein, Dan; Cam, Ertugrul; Ungethuem, Udo; Hatz, Florian; Schäfer, Juliane; Samnick, Samuel; Israel, Ina; Kleinschnitz, Christoph; Orts-Gil, Guillermo; Moch, Holger; Zeis, Thomas; Schaeren-Wiemers, Nicole; Seeberger, Peter

    2015-03-01

    Cerebral inflammation plays a crucial role in the pathophysiology of ischemic stroke and is involved in all stages of the ischemic cascade. Fullerene derivatives, such as fullerenol (OH-F) are radical scavengers acting as neuroprotective agents while glucosamine (GlcN) attenuates cerebral inflammation after stroke. We created novel glucosamine-fullerene conjugates (GlcN-F) to combine their protective effects and compared them to OH-F regarding stroke-induced cerebral inflammation and cellular damage. Fullerene derivatives or vehicle was administered intravenously in normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) immediately after transient middle cerebral artery occlusion (tMCAO). Infarct size was determined at day 5 and neurological outcome at days 1 and 5 after tMCAO. CD68- and NeuN-staining were performed to determine immunoreactivity and neuronal survival respectively. Cytokine and toll like receptor 4 (TLR-4) expression was assessed using quantitative real-time PCR. Magnetic resonance imaging revealed a significant reduction of infarct volume in both, WKY and SHR that were treated with fullerene derivatives. Treated rats showed an amelioration of neurological symptoms as both OH-F and GlcN-F prevented neuronal loss in the perilesional area. Cerebral immunoreactivity was reduced in treated WKY and SHR. Expression of IL-1β and TLR-4 was attenuated in OH-F-treated WKY rats. In conclusion, OH-F and GlcN-F lead to a reduction of cellular damage and inflammation after stroke, rendering these compounds attractive therapeutics for stroke.

  2. Motor recovery via aberrant pyramidal tract in a patient with a cerebral peduncle infarct

    Institute of Scientific and Technical Information of China (English)

    Sang Seok Yeo; Sung Ho Jang

    2011-01-01

    The presence of the aberrant pyramidal tract has been demonstrated by several studies; however, little is known about its role in motor recovery in stroke patients. In the present study, we reported a 69-year-old right-handed female patient with an infarct in the mid to lateral portion of the left cerebral peduncle, who showed an aberrant pyramidal tract by diffusion tensor tractography. The patient presented with severe weakness of the right extremities at stroke onset. The patient showed progressive motor recovery as much as being able to extend the affected extremities against some resistance at 6 months after onset. At 20 months after stroke onset, motor function of the left extremities had recovered to a nearly normal state. Diffusion tensor tractography results showed that the PT was disrupted at the lower midbrain of the affected (left) hemisphere at 3 weeks after stroke onset and this disruption was not changed at 20 months. An aberrant pyramidal tract in the left hemisphere was also observed, which originated from the primary motor cortex and descended through the corona radiata, posterior limb of the internal capsule, thalamus, the medial lemniscus pathway from the midbrain to the pons, and then entered into the pyramidal tract area at the pontomedullary junction. Transcranial magnetic stimulation did not elicit motor evoked potential from the affected hand muscle at 3 weeks, but it elicited motor evoked potential with mildly delayed latency and low amplitude in the affected hand muscle at 20 months. The main motor functions of the affected extremities in this patient appeared to be recovered via this aberrant pyramidal tract.

  3. Association of COMT gene polymorphisms with cerebral infarction in Han people of Tianjin

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    WANG Jin-huan

    2013-04-01

    Full Text Available Background Catechol-O-methyltransferase (COMT has a key function in thedegradation of catecholamines and inactivating estrogen. A common polymorphism in the COMT gene is guanine-adenine (G-A point mutation on rs4680, which causes a valine (Val substitution to methionine (Met in 108 and (or 158 amino acid by this gene and is responsible for lowered activity of the enzyme. The Val/Met polymorphism has been recognized to be associated with psychiatric disorders, alcohol dependence and drug side effects, but few study has been done to examine the relationship with cerebral infarction (CI. The objective of this study is to investigate the relationship between the polymorphisms of COMT gene and CI. Methods The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP was used to detect COMT Val158Met genotype in 181 CI patients and 148 cases of controls. Meanwhile the serum levels of glucose, total cholesterol (TC, triglyceride (TG, low-density lipoprotein cholesterol (LDL-C , high-density lipoprotein cholesterol (HDL-C , apolipoprotein B (ApoB and ApoA in CI group were detected. Results The frequency of Val allele (78.45% and Val/Valgenotype (61.33% in CI was significantly higher than that in the control group (68.24% and 45.95%, P 0.05 than that in the control group. The serum levels of glucose, TC, TG, LDL-C, HDL-C, ApoB, ApoA and the frequency of hypertension had no difference between Val/Val genotype and Val/Met + Met/Met genotypes ( P > 0.05, for all. Conclusion The frequencies of Val allele and Val/Val genotype can be considered as genetic risk factors of male CI patients. The effect of COMT on CI is not related to blood pressure, serum lipid and glucose.

  4. A study on cognitive impairment and gray matter volume abnormalities in silent cerebral infarction patients

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    Luo, Wei; Wei, Xiaofeng; Li, Mengxiong [The First Affiliated Hospital of Yangtze University, Biomedical Engineering Laboratory, Jingzhou, Hubei (China); Jiang, Xun [Renmin Hospital of Wuhan University, Biomedical Engineering Laboratory, Wuhan, Hubei (China); Li, Shanshan [JingZhou City Central Blood Bank, Jingzhou, Hubei (China)

    2015-08-15

    The relationship between silent cerebral infarction (SCI) and the integrity of cognitive function is unknown. We intended to investigate whether cognitive impairment is associated with gray matter volume (GMV) in the SCI patients. Sixty-two patients with SCI and 62 age- and gender-matched healthy controls (HC) were evaluated with P300 test, Montreal Cognitive Assessment (MoCA) test, Hamilton Anxiety Scale (HAMA), and Hamilton Depression Scale (HDRS). Whole brain high-resolution T1-weighted images were processed with SPM12b software and analyzed by voxel-based morphometry (VBM). Correlation analysis was performed between the GMV and the scores of MoCA Scale, P300 latency, P300 amplitude, HAMA, HDRS, age, and educational level. The brains of the SCI patients have a significant reduction in GMV in the left superior and inferior frontal gyrus, left superior temporal gyrus, right middle temporal gyrus, and bilateral hippocampus gyrus (p < 0.01, FDR correction). No significant increase of GMV was detected. The GMV of their frontal and temporal lobes is positively correlated with the score of MoCA scale and P300 amplitude (r ≥ 0.62, p < 0.01). The GMV of frontal, temporal, and hippocampus is negatively correlated with P300 latency (r ≤ -0.71, p < 0.05). No significant correlation between the GMV of abnormal brain regions and another two clinical characteristics was found. SCI patients have impaired cognitive function and reduced GMV compared to the HC subjects. The neuropathological basis of such cognitive deficits in SCI patients might be a reduced GMV. (orig.)

  5. Relevance Study on Cerebral Infarction and Resistin Gene Polymorphism in Chinese Han Population

    Science.gov (United States)

    Yan, Aijuan; Cai, Gaoyu; Fu, Ningzhen; Feng, Yulan; Sun, Jialan; Maimaiti, Yiming; Zhou, Weijun; Fu, Yi

    2016-01-01

    Recent research on genome-wide associations has implicated that the serum resistin level and its gene polymorphism are associated with cerebral infarction (CI) morbidity and prognosis, and could thereby regulate CI. This study aimed to investigate the association between the resistin single nucleotide polymorphism (SNP) and the susceptibility to CI in the Chinese Han population. A total of 550 CI patients and 313 healthy controls were genotyped. Nine SNPs of the resistin gene previously shown were sequenced and assessed for an association with CI. The numbers of GG genotype carriers of rs3219175 and rs3486119 in the CI group were significantly higher than those in the control group among the middle-aged group (aged 45-65), at 76% vs 67.9% (P=0.025) and 75.5% vs 67.9% (P=0.031). rs3219175 and rs34861192 were associated with CI in the dominant and superdominant models according to the genetic model analysis (P<0.05). Meanwhile, there was strong linkage disequilibrium among the rs34124816, rs3219175, rs34861192, rs1862513, rs3745367, 180C/G and rs3745369 sites. In a haplotype analysis, the occurrence rate of the haplotype AGGCAGC was 1.97 times (P<0.05) higher in the patient group than in the control group. In addition, the numbers of GG genotype carriers of rs3219175 and rs3486119 in the middle-aged male CI patients and the middle-aged small artery occlusion (SAO) CI patients were higher than those in the control group (P<0.05). In the Chinese Han middle-aged population, the GG gene type carriers of the resistin gene sites rs3219175 and rs34861192 had a high risk for CI onset, especially in middle-aged male patients and SAO CI in all middle-aged patients. PMID:27699082

  6. Clinical Studies on Treatment of Acute Cerebral Infarction with Xueshuantong Injection

    Institute of Scientific and Technical Information of China (English)

    DUJin-hang; RENZai-fang

    2003-01-01

    Objective:To observe the effect of Xueshuantong injection(XST,血栓通注射液)with its ingredient as Notoginseng saponin,on acute cerebral infarction(ACI) and on blood coagulation and fibri-nolysis,so as to comprehensively analyse the mechanism of XST.Methods:Fifty ACI patients were ran-domly divided into 2 groups,and XST group(30 patients)was treated with XST, and the control group (20 patients)given low molecular dextrose,as well as low molecular heparin calcium.The course of treat-ment for both groups was 15 days.The changes of effective rate,score of neurologic impairment,tissue-type plasminogen activator(tPA),inhibitor of plasminogen activator(PAI),D-D dimmer,antithrombin-Ⅲ(AT-Ⅲ),and fibrinogen(Fbg) were all observed.Results:The total effective rate of XST group was 73.33%,that of the control group 65.00%.After the therapy,plasma level of tPA,ratio of tPA/PAI,and AT-Ⅲ content were increased obviously,while the plasma level of PAI and D-D dimmer were de-creased significantly(all P0.05).Conclusion:XST injection could be effective to ACI, the mechanism of which is probably related to improving the balance between plasminogen activator and its inhibitory factor,increasing the acitvity of fi-brinolysin,inactivating thrombin,inhibiting platelet aggregation induced by thrombin,and decreasing blood coagulation.

  7. Risk factors and ankle brachial indexes in cerebral infarction combined with peripheral arterial disease

    Institute of Scientific and Technical Information of China (English)

    Huihua Liu; Jun Wang

    2006-01-01

    BACKGROUND: Ankle brachial index(ABI)is widely involved in researches and clinical application of peripheral vascular injury of patients with diabetes (DM);however ,the application in cerebral infarction(CI)is rare.OBJECTIVE: To investigate the possible risk factor of cerebral infarction plus peripheral arterial disease(PAD),compare metabolic characteristics of patients who having CI plus PAD or only having CI,and understand the significance of ABI on screening and diagnosing CI plus PAD of lower limb.DESIGN: Contrast observation based on CI patients.SETTING: Deparment of Neurology,Nanxishan Hospital of Guangxi Zhang Autonomous Region.PARTICIPANTS:A total of 124 CI patients were selected from Department of Neurology.Nanxishan Hospital of Guangxi Zhuang Autonomous Region from July 2005 to April 2006,including 72 males and 52 females aged from 45 to 88 years.All patients met the diagnostic criteria of cerebrovascular disease established by National Academic Conference of Cerebrovascular Diseases in 1995 and determined as cerebral infarction with MRI or CT examination.All patients provided informed consent.There were 46 cases(37.2%)with CI plus PAD and 78 cases(62.8%)only with CI.METHODS: Blood pressure of bilateral ankles and upper extremities was measured at plain clinostatism with DINAMAP blood pressure monitor(GE Company).The ratio between average systolic pressure of lateral ankle and average systolic pressure of both upper extremities was regarded as ABI.The normal ABI was equal to or more than 0.9.If ABI<0.9 occurred at one side,patients were diagnosed as PAD.On the second morning after hospitalization,blood was collected to measure fasting blood glucose(FBG),2-hour postprandial blood glucose(PBG2h),glycosylated hemoglobin(HbAlc),triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C).Among them,blood glucose.lipid and other biochemical markers were measured with enzyme chemistry assay

  8. Effect of decompressive craniectomy combined with temporal muscle sticking on immunological function and inflammatory cytokines in patients with cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Yong-Sheng Zhang; Shi-Duo Xie; Dong-Gang Zhao; Jun Yan

    2016-01-01

    Objective:To observe the effect of decompressive craniectomy combined with temporal muscle sticking on the immunological function and inflammatory cytokines in patients with cerebral infarction.Methods:A total of 96 patients with cerebral infarction who were admitted in our hospital were included in the study and divided into the observation group and the control group according to different treatment protocols. The patients in the observation group were given decompressive craniectomy combined with temporal muscle sticking, while the patients in the control group were given the conservative treatment. The changes of immunological function and serum inflammatory cytokines indicators before and after treatment in the two groups were compared.Results: IgG, IgA, IgM, CD3+, CD4+, and CD8+ 1 d and 3 d after treatment in the two groups were significantly reduced when compared with before operation (P<0.05). IgG, IgA, IgM, CD3+, CD4+, and CD8+ 1 and 3 d after treatment in the observation group were significantly higher than those in the control group (P<0.05). The levels of various serum inflammatory cytokines after treatment in the observation group were significantly reduced when compared with before treatment (P<0.05). S100β, IL-6, TNF-α, ET-1, and hs-CRP contents at each timing point in the observation group were significantly lower than those in the control group (P<0.05).Conclusions:The decompressive craniectomy combined with temporal muscle sticking can effectively reduce the inflammatory reaction in patients with cerebral infarction, and promote the recovery of immunological function.

  9. Forty-six Cases of Acute Cerebral Infarction Treated with the Combined Use of Acupuncture and Drugs

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective: To observe the clinical therapeutic effects of treatment for acute cerebral infarction with the combined use of acupuncture and drugs, and study the therapeutic mechanism. Methods: 88 cases of acute cerebral infarction were divided randomly into two groups, a treatment group of 46 cases treated with acupuncture, Danshen Zhushe Ye (丹参注射液 Saliva Injection) and routine western drugs and a control group of 42 cases treated simply with drugs. The therapeutic effects were evaluated based on the evaluation criteria for damage of the nerve function. Observation was also made on changes in the skull CT images, and in the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-px), and nitric oxide synthase (NOS) in serums, and levels of malondialdehyde (MDA) and nitric oxide (NO) in serums. Results: After treatment for 15 days, the total effective rate of the treatment group reached 80.43%, while that of the control group was 61.90%, showing significant differences. The effective rate shown by the skull CT images of the treatment group was 51.61%, while that of the control group was 45.16%, showing no significant differences. But as compared with the control group, the activities of SOD and GSH-px in serums were significantly enhanced, and the levels of MDA and NO, and activity of NOS in serums were significantly decreased in the treatment group. Conclusion: The prompt acupuncture treatment of acute cerebral infarction can markedly raise the clinical therapeutic effects, improve the activity of SOD and GSH-px in serums, lower down the level of MDA in serum, and markedly decrease NO level and NOS activity in serums.

  10. Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats.

    Science.gov (United States)

    Fisher, M; Meadows, M E; Do, T; Weise, J; Trubetskoy, V; Charette, M; Finklestein, S P

    1995-11-01

    Basic fibroblast growth factor (bFGF) is a polypeptide that supports the survival of brain cells (including neurons, glia, and endothelia) and protects neurons against a number of toxins and insults in vitro. This factor is also a potent dilator of cerebral pial arterioles in vivo. In previous studies, we found that intraventricularly administered bFGF reduced infarct volume in a model of focal cerebral ischemia in rats. In the current study, bFGF (45 micrograms/kg/h) in vehicle, or vehicle alone, was infused intravenously for 3 h, beginning at 30 min after permanent middle cerebral artery occlusion by intraluminal suture in mature Sprague-Dawley rats. After 24 h, neurological deficit (as assessed by a 0- to 5-point scale, with 5 = most severe) was 2.6 +/- 1.0 in vehicle-treated and 1.5 +/- 1.3 in bFGF-treated rats (mean +/- SD; N = 12 vs. 11; p = 0.009). Infarct volume was 297 +/- 65 mm3 in vehicle- and 143 +/- 135 mm3 in bFGF-treated animals (p = 0.002). During infusion, there was a modest decrease in mean arterial blood pressure but no changes in arterial blood gases or core or brain temperature in bFGF-treated rats. Autoradiography following intravenous administration of 111In-labeled bFGF showed that labeled bFGF crossed the damaged blood-brain barrier to enter the ischemic (but not the nonischemic) hemisphere. Whether the infarct-reducing effects of bFGF depend on intraparenchymal or intravascular mechanisms requires further study.

  11. Effect of Solitaire AB stent thrombectomy on vascular endothelial function and inflammatory cytokines in patients with progressive cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Zhi-Bao Wu; Xue-Juan Han; Zi-Hao Zhang; Wen-Liang Zhang; Liang Liu

    2016-01-01

    Objective:To observe the effect of Solitaire AB stent thrombectomy on the vascular endothelial function and inflammatory cytokines in patients with progressive cerebral infarction.Methods:A total of 58 patients with progressive cerebral infarction who were admitted in our hospital were included in the study and divided into the observation group and the control group according to different treatment protocols with 29 cases in each group. The patients in the control group were given the conservation treatment. On this basis, the patients in the observation group were given Solitaire AB stent thrombectomy. The changes of vascular endothelial function and inflammatory cytokines before and after treatment in the two groups were compared.Results:ET-1 after treatment in the two groups was significantly reduced, while NO and CGRP were significantly elevated when compared with before treatment (P<0.05). ET-1 after treatment in the observation group was significantly lower than that in the control group (P<0.05), while NO and CGRP were significantly higher than those in the control group (P<0.05). S100β protein, IL-6, TNF-α, hs-CRP, and MMP-9 levels after treatment in the two groups were significantly reduced when compared with before treatment (P<0.05). The above indicators after treatment in the observation group were significantly lower than those in the control group (P<0.05). MCA and ACA blood flow velocity after treatment in the two groups were significantly elevated when compared with before treatment (P<0.05). MCA and ACA blood flow velocity after treatment in the observation group were significantly higher than those in the control group (P<0.05).Conclusions:Solitaire AB stent thrombectomy can effectively reduce the inflammatory reaction in patients with progressive cerebral infarction, and improve the vascular endothelial function and blood supply for brain tissues.

  12. β-七叶皂甙钠对外伤性脑梗死患者早期康复的影响%Effect of sodium β-escin on early rehabilitation of the patients with traumatic cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    张银清; 陈汉民; 廖圣芳; 余锦刚

    2002-01-01

    Background:Sodium β escin is involved in Aesculus chinensis Bunge, could increase the tension of veins,improve blood rheology making the blood flow faster,fasten the absorption of the edema around the cerebral infarction,and improves blood supply in the cerebral infarction and around it,and promote the recovery of brain function.

  13. 2型糖尿病合并脑梗死与胰岛素抵抗的相关性研究%Study on correlation between insulin resistance and cerebral infarction following diabetes mellitus II

    Institute of Scientific and Technical Information of China (English)

    刘恩琴; 陈诗鸿

    2002-01-01

    Background:Diabetes mellitus is associated with increased incidence of cerebrovascular diseases.As basical factor involved in pathogenesis of diabetes,insulin resistance is related to cerebral infarction attack.In this study, study on correlation between insulin resistance and cerebral infarction following diabetes mellitus was conducted.

  14. 高压氧对急性脑梗死临床应用分析%CLINICAL APPLICATION OF HYPERBARIC OXYGENATION TO ACUTE CEREBRAL INFARCTION

    Institute of Scientific and Technical Information of China (English)

    邵伟波

    2002-01-01

    Objective:To determine the effect of hyperbaric oxygenation(HBO) on treating acute cerebral infarction(ACI). Methods: We randomly divided 60 patients with acute cerebral infarction into the treatment group and the control group. Hyperbaric oxygenation treatment was applied in the treatment group as routine drug therapy was used. The neurological function, living ability, clinical therapeutic effectiveness and hemorrheology changes of pa tients in the two groups before and after treatment were observed and evaluated. Results: The indexes of treatment were obviously improved one month after treatment (P < 0.05 ). Clinical effective rate was 93.3 % in this group,which was obviously higher than that of the control group(P < 0.05). Conclusion: Hyperbaric oxygenation can accelerate the recovery of neurological function of patients with acute cerebral infarction.

  15. Comparative Study on the Pulse Wave Variables and Sasang Constitution in Cerebral Infarction Patients and Healthy Subjects

    Directory of Open Access Journals (Sweden)

    Ko KiDuk

    2007-06-01

    Full Text Available This study was performed to determine whether a pulse analyzer was useful 1 to characterize the variables of pulse wave of cerebral infarction patieno (CI, compared with those of healthy subjects, as well as 2 to determine Sasang Constitution in CI and healthy subjects. 1. Calibrated in Gwan, the amount of energy(Energy, height of main peak(H1, height of aorticvalley(H2, height of aortic peak(H3, total area of pulse wave(At, and area of main peak width(Aw of the CI group were higher than those of the healthy group. 2. Calibrated in Cheek, Energy, H1, H2, H3, height of valve valley(H4, At, Aw, and main peak angle(MPA of the CI group were higher than those of the healthy group. 3. Among the healthy (subjects group, Taeumin showed the highest contact pressure(CP and height of valve peak(H5 calibrated in Chon. The main peak width divided by whole time of pulse wave(MPW/T calibrated in Gwan and Cheok, was highest in Soyangin and was lowest in Taeumin. The H3 divided by H1(H3/H1 and the time to valve valley minus the time to main peak and divided by T[(T4-T1/T] calibrated in Cheek were highest in Soyangin. The time to main peak(T1 was longest in Soumin. 4. Among the CI group, At calibrated in Chon was widest in Taeumin and was narrowest in Soumin The time to aortic peak(T3 calibrated in Cheek was longest in Soumin and was shortest in Soyangin. The time to valve peak(T5 was shortest in Soyangin. 5. There were main effects of cerebral infarction in the area of systolic period(As and area of diastolic period(Ad calibrated in Chon, Energy calibrated in Cwan, and Energy, H1, H2, H3, (H4+H5/Hl, and MPA calibrated in Cheek. 6. There were main effects of Sasang Constitution in (T4-T1/T, area of systolic period(As, and Ad calibrated in Chon. 7. The interactions between the cerebral infarction and Sasang Constitution were observed in H5/H1 , T, At, As, Ad, and MPA calibrated in Chon, H4, T4, (T4-T1/T, As, and Ad calibrated in Cwan, and 74,75, and MPW calibrated

  16. [Foix-Chavany-Marie syndrome: anarthria and severe dyphagia after sequential bilateral infarction of the middle cerebral artery].

    Science.gov (United States)

    Guhra, M; Poppenborg, M; Hagemeister, C

    2008-02-01

    Bilateral lesions of the opercula frontoparietalia are uncommon and cause a symptom cluster including anarthria, severe dysphagia, inability to chew and sometimes facial paresis. At the same time there is an automatic-voluntary dissociation, meaning that the affected muscles are functional within the scope of involuntary movements. This syndrome is known as Foix-Chavany-Marie syndrome (FCMS), (bilateral) anterior operculum syndrome or facio-pharyngo-glosso-masticatory diplegia. We report the case of a patient who suffered from FCMS after having infarctions in the territory of the middle cerebral artery on each side 4 years apart.

  17. Risk factors of recurrent cerebral infarction%复发性脑梗死的危险因素分析

    Institute of Scientific and Technical Information of China (English)

    王福英; 孙培荣; 孙丰辉

    2011-01-01

    Objective To explore the risk factors of recurrent cerebral infarction. Methods 50 patients with recurrent cerebral infarction were analyzed retrospectively and 51 patients with first cerebral infarction were enrolled as the control group. A total of 12 factors were analyzed with chisquare test or t test, and their af fected degree was determined with mutiple logistic regression analysis, and all risk factors were analyzed with multi-variable correlation analysis. Results The proportions of smoking history,diabetes history, hypertensive disease history, Hyperlipidemia history, TIA history, fibrillation atrial history and hyperhomocysteinemia on admission were all significantly higher in the recurrent group (P<0. 05). The multivariable logistic regression analysis showed that the important risk factors of early exacerbation of ischemic stroke were diabetes history (P= 0. 030) ,TIA history (P = 0. 043) ,fibrillation atrial history (P= 0. 016) and hyperhomocysteinemia (P = 0.042). multi variable correlation analysis showed that these 5 factors were not correlative between each other.Conclusions The independent risk factors of recurrent cerebral infarction are the diabetes history, TIA histo ry, fibrillation atrial history and hyperhomocysteinemia.%目的 探讨复发性脑梗死的危险因素.方法 对50例复发性脑梗死患者及51例初发性脑梗死患者的危险因素中12个因素进行对比分析,并用多元Logistic回归分析各因素与复发性脑梗死的关系,用多元相关分析各危险因素间的相关性.结果 复发性脑梗死组的吸烟史、糖尿病史、高血压病史、高脂血症史、TIA史、房颤史、Hhcy的比例明显高于初发性脑梗死组(P均<0.05).多元Logistic回归分析显示,糖尿病史(P=0.030)、TIA史(P=0.043)、房颤病史(P=0.016) 和Hhcy(P=0.042)是复发性脑梗死的主要危险因素.多元相关分析显示该5项因素间没有相关性.结论 糖尿病史、TIA史、房颤病史和Hhcy是

  18. Correlation of diseased region and area with neglect and other neuropsychological dysfunctions in patients with cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Jianping Niu; Hongyu Zhang; Bo Liu; Yiwen Zhang; Yehua Song; Lihong Chen

    2006-01-01

    BACKGROUND: Previous studies reported that frontal-temporal-parietal-occipital pathological changes and diseased range in the right cerbral hemisphere were correlated with neglect.But studies on the correlation of neglect with diseased region and area in patients who suffer from initial attack of single focus of cerebral infarction(CI) in left and right cerebral hemispheres are few.OBJECTIVE: To observe the status of neglect in patients who suffer from single focus of CI in cerebral hemisphere and analyze the correlation of neglect with diseased region and area of CI.DESIGN: Case analysis SETTING: Treatment Center for Cardiocerebrovascular Disease,Second Hospital of Xiamen city;Department of Neurology,First Hospital Affiliated to Baotou Medical College.PARTICIPANTS: All the CI patients hospitalized in the Department of Neurology.First Hospital Affiliated to Baotou Medical College from June 1998 to May 2001 were retrieved.Inclusive criteria:①Patients who suffered from initial attack of CI.which was confirmed by skull CT or MRI within 24 hours after onset and presented single focus in cerebral hemisphere. ②be conscious and could cooperate in the examination. ③did not receive formal education, but could do accounts and some simple writing and reading. ④Patients with homonymous hemianopia were excluded through the examination of perimeter.⑤Informed consents were obtained from all the patients.Among 67 patients who met the inclusive criteria.33 suffered from CI in the left cerebral hemisphere and 34 in the right cerebral hemisphere.METHODS:①Patients received neglect supplement examination and Chinese aphasia examination within 2.5 to 3 months after the attack of CI.The diagnostic criteria of neglect in the tests of line cancellation. 1ine bisection and copying the figures were as follows:In the line cancellation test based on the method of Albert.patients who could not cancel one or more lines were regarded as abnormal.In the line bisection test based on the

  19. Analysis of 104 patients with watershed cerebral infarction%分水岭脑梗塞104例分析

    Institute of Scientific and Technical Information of China (English)

    杨全玉; 马丽; 崔亚平

    2000-01-01

    Objective: To study the etiology and CT of watershed cerebral infarction. Methods: Basing on the results of CT,the classifications of Bigaussluvskg and Kashiara were consulted. Results: Seventy eight of 104 (75%) with watershed cere-bral infarction were hypertension in the past and/or elevation of blood pressure of the day of 104 cases, anterior type of cerebral cortex had 18 cases, posterior type of cerebral cortex 22, inferior type of cerebral cortex 64 ( in cluding anterior type, superiortype,and lateral type).Most of initial symptoms (54%) were weakness of limbs. Forteen of 18 cases(77.8% ) with anteriortype of cerebral cortex were hemiplegia, Fifteen of 22 (68.2 % ) with posterior type of cerebral cortex were hemiplegia. Therewere focus and complex clinical manffestationos in the inferior type of cerebral cortex. The results of CT showed that the anteri-or type of cerebral cortex located the juntion of ACA/MCA, corresponding to the mid-gynus in Frontal lobe, posterior type ofcerebral cortex located MCA/PCA and among ACA/MCA/PCA corresponding to the occipital lobe and. Temporal,parietal,o-clipital lobe. Inferior type of cerebral cortex located between the cortex branch and deeping, arteriole of MCA, corresponding tothe basal ganglia and the side of the lateral rentricles body. Conclusion: The result revealed that the main case of watershedcerebral infarction, mag be associated with hypertension, the clinical manifestation mostly was hemiplegia. The CT showed thatthe diseases located in the junction of ACA, MCA, PCA, especialy in the basal ganglia and the side of the lateral ventriles bodythat MAC sigply.%目的:探讨分水岭脑梗塞的病因和CT特点。方法:根据CT结果,参考Bigaussluvskg和Kashihara二氏分型法。结果:104例中,既往有高血压及/或发病时血压升高者78例,占75%。其中皮层前型18例,皮层后型22例,皮层下型64例,(内含皮层下前型,上型和外侧型)。首发症

  20. Relationship between the cytotoxin-associated gene-A status of H pylori strains and cerebral infarction in European Caucasians and Chinese Han: A meta-analysis

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    AIM: To study the relationship between the cytotoxin associated gene-A (CagA) status of H pylori strains and cerebral infarction among European Caucasians and Chinese Han by conducting a meta-analysis. METHODS: Ten case-control studies, with data on a total of 907 cases and 966 controls, were retrieved and considered; disqualified studies were excluded. The included studies were then tested for heterogeneity, and a meta-analysis was performed. RESULTS: The combined data revealed CagA-bearing strains of H pylori which cause chronic infection are associated with an increased risk of cerebral infarction (OR=2.66,95% CI:2. 17-3.26),but no such relationship was found with CagA-negative strains (OR =0.74,95% CI:0.49-1.10) in the overall population. We performed subgroup analyses, dividing the overall population into European Caucasians and Chinese Hart subgroups, and analyzed the studies according to their subgroup classification. Through the subgroup analysis, an association between cerebral infarction and CagA bearing strains was found in both subgroups (OR=2.60,95% CI:1.93-3.49 in Chinese Han; OR=2.71,95% CI:2.05-3.59 in European Caucasians),but no significant association was found between cerebral infarction and CagA-negative strains (OR=0.81,95% CI:0.45-1.48 in Chinese Han; OR=0.64,95% CI:0.37-1.09 in European Caucasians). CONCLUSION: These results suggest CagA-bearing strains of Hpylori are significantly associated with susceptibility to cerebral infarction in Chinese Han and European Caucasians, but that CagA-negative strains are not a definite predisposing factor in either subgroup. The magnitude of this association with cerebral infarction needs to be confirmed by prospective studies and combined studies of H pylori eradication.

  1. Analysis of 58 neonatal cases with cerebral infarction%新生儿脑梗死58例分析

    Institute of Scientific and Technical Information of China (English)

    李志华; 陈超

    2013-01-01

    目的 分析近年来收治的58例新生儿脑梗死病例的临床资料及预后,为临床诊治提供可借鉴的经验.方法 对复旦大学附属儿科医院新生儿科1999年1月至2010年12月收治的58例新生儿脑梗死病例的临床资料及随访结果进行回顾性分析.结果 58例脑梗死患儿中52例为足月儿,6例为早产儿.缺血性梗死51例(占87.9%),出血性梗死7例(占12.1%).围产期缺氧缺血是最常见的高危因素(占46.6%).惊厥是新生儿脑梗死最常见的首发症状及病程中最多见的临床表现(占77.6%),其次为阵发性青紫、呼吸暂停及反应差.新生儿脑梗死最易累及大脑中动脉,且左侧多见.新生儿脑梗死急性期以支持和对症治疗为主.预后不良的患儿中,梗死多累及深部灰质核团或波及多个脑叶.结论 围产期缺氧是常见的高危因素.惊厥是最常见的早期临床表现.弥散加权成像技术对急性期脑梗死的诊断价值较高.不良预后的患儿中,梗死多累及深部灰质或范围较广.早期发现、结合头颅影像学检查作出诊断,对于指导康复治疗、改善预后有积极的意义.%Objective Cerebral infarction (CI) is one of severe diseases of central nervous system in neonates,and some infants with CI could have poor prognosis in the long term.This study aimed to analyze the clinical data and prognosis of all neonatal cases with cerebral infarction in recent years and to help future clinical work.Method Totally 58 neonatal cases with CI admitted to NICU of the hospital from January 1999 to December 2010 were included in this study.We analyzed all clinical data and prognosis by retrospective analysis.Results Fifty-two term babies and six preterm babies were included.There were altogether 51 cases with asphyxia and 7 with hemorrhagic cerebral infarction.Perinatal hypoxia-ischemia was the most common high-risk factor and it accounted for 46.6%.Seizure was the most frequent initial symptom and

  2. Ipsilateral versus bilateral limb-training in promoting the proliferation and differentiation of endogenous neural stem cells following cerebral infarction in rats

    Institute of Scientific and Technical Information of China (English)

    Xiyao Yang; Feng Zhu; Xiaomei Zhang; Zhuo Gao; Yunpeng Cao

    2012-01-01

    We investigated the effects of ipsilateral versus bilateral limb-training on promotion of endogenous neural stem cells in the peripheral infarct zone and the corresponding cerebral region in the unaffected hemisphere of rats with cerebral infarction. Middle cerebral artery occlusion was induced in Wistar rats. The rat forelimb on the unaffected side was either wrapped up with tape to force the use of the paretic forelimb in rats or not braked to allow bilateral forelimbs to participate in training. Daily training consisted of mesh drum training, balance beam training, and stick rolling training for a total of 40 minutes, once per day. Control rats received no training. At 14 days after functional training, rats receiving bilateral limb-training exhibited milder neurological impairment than that in the ipsilateral limb-training group or the control group. The number of nestin/glial fibrillary acidic protein-positive and nestin/microtubule-associated protein 2-positive cells in the peripheral infarct zone and in the corresponding cerebral region in the unaffected hemisphere was significantly higher in rats receiving bilateral limb-training than in rats receiving ipsilateral limb-training. These data suggest that bilateral limb-training can promote the proliferation and differentiation of endogenous neural stem cells in the bilateral hemispheres after cerebral infarction and accelerate the recovery of neurologic function. In addition, bilateral limb-training produces better therapeutic effects than ipsilateral limb-training.

  3. Brief Screening of Vascular Cognitive Impairment in Patients With Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Without Dementia

    OpenAIRE

    2016-01-01

    Background and Purpose - Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic form of cerebral small vessel disease leading to early-onset stroke and dementia, with younger patients frequently showing subclinical deficits in cognition. At present, there are no targeted cognitive screening measures for this population. However, the Brief Memory and Executive Test (BMET) and the Montreal Cognitive Assessment (MoCA) have shown utilit...

  4. Consistency between magnetic resonance diffusion-weighted images and pathological findings in a hyperacute cerebral infarction rabbit model

    Institute of Scientific and Technical Information of China (English)

    Mingwu Lou; Zengyan Li; Weidong Hu; Yi Fan; Xiurong Wang; Guangfu Yang

    2009-01-01

    BACKGROUND:Because magnetic resonance diffusion-weighted imaging is sensitive to water molecule movement,it has particular advantages for early diagnosis of cerebral infarction.However,the relationship between apparent diffusion coefficient changes with ischemia time,particularly relative apparent diffusion coefficient and tissue pathological changes remains controversial.OBJECTIVE:To explore the correlation between apparent diffusion coefficient changes and pathologic changes in hyperacute cerebral infarction.DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment of neuroimaging.The study was performed at the Laboratory of Radiology Department,Longgang Central Hospital of Shenzhen from October 2007 to October 2008.MATERIALS:Magnetic resonance scanner was purchased from Philips Medical Systems,Best,the Netherlands.METHODS:A total of 42 healthy,adult,New Zealand rabbits were randomly assigned into sham-operation,ischemia 0.5-,1-,2-,3-,4-,and 6-hour groups,with six animals in each group.Local cerebral ischemia model was established by right middle cerebral artery occlusion,and cranial MRI scanning and pathologic observation were performed,respectively,at 0.5,1,2,3,4,and 6 hours following ischemia.The middle cerebral artery of sham-operation group was only exposed,but not occluded.Images at the above-mentioned time points were also collected.MAIN OUTCOME MEASURES:Apparent diffusion coefficient and relative apparent diffusion coefficient values of abnormal signal on diffusion-weighted imaging were calculated and compared with pathological changes in the ischemic region.RESULTS:No abnormal diffusion-weighted imaging signals or pathological changes were observed in the sham-operation group.Abnormal signal intensity on diffusion-weighted imaging was first observed in the 0.5-hour group.Apparent diffusion coefficient and relative apparent diffusion coefficient values decreased in all middle cerebral artery occlusion rabbits and reached lowest levels at 3 hours

  5. Asymmetry in the brain influenced the neurological deficits and infarction volume following the middle cerebral artery occlusion in rats

    Directory of Open Access Journals (Sweden)

    Zhang Meizeng

    2008-12-01

    Full Text Available Abstract Background Paw preference in rats is similar to human handedness, which may result from dominant hemisphere of rat brain. However, given that lateralization is the uniqueness of the humans, many researchers neglect the differences between the left and right hemispheres when selecting the middle cerebral artery occlusion (MCAO in rats. The aim of this study was to evaluate the effect of ischemia in the dominant hemisphere on neurobehavioral function and on the cerebral infarction volume following MCAO in rats. Methods The right-handed male Sprague-Dawley rats asserted by the quadrupedal food-reaching test were subjected to 2 hours MCA occlusion and then reperfusion. Results The neurological scores were significantly worse in the left MCAO group than that in the right MCAO group at 1 h, 24 h, 48 h and 72 h (p 0.05 respectively. There was a trend toward better neurobehavioral function recovery in the right MCAO group than in the left MCAO group. The total infarct volume in left MCAO was significantly larger than that in the right (p Conclusion The neurobehavioral function result and the pathological result were consistent with the hypothesis that paw preference in rats is similar to human handedness, and suggested that ischemia in dominant hemisphere caused more significant neurobehavioral consequence than in another hemisphere following MCAO in adult rats. Asymmetry in rat brain should be considered other than being neglected in choice of rat MCAO model.

  6. [Acute promyelocytic leukemia (APL) resulting in broad cerebral infarction during all-trans retinoic acid (ATRA) treatment].

    Science.gov (United States)

    Ikeda, Y; Yoshinaga, K; Iki, S; Ohbayashi, Y; Urabe, A

    1994-02-01

    A 27-year-old woman visited Kanto Teishin Hospital complaining of fever and petechiae in September, 1992. Her fetus had suddenly died in the uterus two weeks before (in the sixth month of pregnancy). Total white blood cell (WBC) count was 3.2 x 10(3)/microliters with 80% promyelocytes. Bone marrow was hypercellular with 90% promyelocytes. Disseminated intravascular coagulation (DIC) was recognized. She was diagnosed as having acute promyelocytic leukemia (APL), and treatment with daily oral administration of all-trans retinoic acid (ATRA) (70 mg/body/day) was begun. On day 4, hemiplegia and aphasia appeared. Broad cerebral infarction was suspected from computed tomography. On day 9, the WBC count increased rapidly, standard chemotherapy was added and she achieved complete remission. ATRA is known to have stimulatory effects on the differentiation of APL cells, but some reports have described thromboembolic events during the administration of ATRA. In this case, ATRA might have affected coagulability resulting in cerebral infarction.

  7. 40例脑梗塞的护理%Nursing care of 40 cases of cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    何建青

    2013-01-01

    目的:探讨对脑梗塞患者精心护理取得的效果。方法对患者进行心理护理、饮食护理、并发症护理、安全护理、日常生活护理等一系列护理。结果经过精心护理,患者恢复得均较好,提高了生存质量。结论对脑梗塞患者进行精心的护理有助于患者康复。%Objective To explore the nursing of patients with cerebral infarction results. Method Psychological nursing, diet nursing, complication nursing, safety nursing, daily life nursing and a series of nursing on patients with.Results After careful nursing, patients recovered well, improve the quality of life. Conclusion Careful nursing on patients with cerebral infarction is helpful to the rehabilitation of patients.

  8. The correlation of the thalamic lesions on MRI with cerebral cortical blood flow in patients with lacunar infarction

    Energy Technology Data Exchange (ETDEWEB)

    Nabatame, Hidehiko; Nakamura, Kazuo; Matsuda, Minoru; Fujimoto, Naoki [Shiga Medical Center, Moriyama (Japan); Fukuyama, Hidenao

    1995-07-01

    We performed MRI and measured cerebral blood flow (CBF) using {sup 123}I-IMP SPECT microsphere model in twenty three right-handed patients with lacunar infarction. Twelve of 23 patients showed chronic deterioration of dysarthria and gait disturbance. The mental function of the patients was evaluated by the Mini-Mental State (MMS) examination. The area of high intensity on T2-weighted images was quantitatively analyzed in the cerebral white matter (WM), lenticular nucleus (LN) and thalamus (THA). The score of MMS was positively correlated with the local CBF in the bilateral frontal, parietal, temporal and occipital cortices (p<0.05). Also, the area of high intensity in the left THA showed a significant negative correlation with local CBF of the bilateral frontal, parietal, temporal and occipital cortices (p<0.001). The high intensity areas of the bilateral LN, right WM and right THA had a significant but weaker negative correlation with local CBF of some cortices. These findings suggest that thalamic lesions on the dominant side play an important role in the reduction of cortical blood flow and the deterioration of mental functions in patients with lacunar infarction. (author).

  9. The Application of Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging in the Diagnosis and Therapy of Acute Cerebral Infarction

    Directory of Open Access Journals (Sweden)

    Ying Han

    2006-01-01

    Full Text Available Diffusion- and perfusion-weighted magnetic resonance imaging (DWI and PWI was applied for stroke diagnose in 120 acute (<48 h ischemic stroke patients. At hyperacute (<6 h stage, it is difficult to find out the infarction zone in conventional T1 or T2 image, but it is easy in DWI, apparent diffusion coefficient (ADC map; when at 3–6-hour stage it is also easy in PWI, cerebral blood flow (CBF map, cerebral blood volume (CBV map, and mean transit time (MTT map; at acute (6–48 h stage, DWI or PWI is more sensitive than conventional T1 or T2 image too. Combining DWI with ADC, acute and chronic infarction can be distinguished. Besides, penumbra which should be developed in meaning was used as an indication or to evaluate the therapeutic efficacy. There were two cases (<1.5 h that broke the model of penumbra because abnormity was found in DWI but not that in PWI, finally they recovered without any sequela.

  10. 急性脑梗死患者合并脑微出血的心脑血管事件发生的研究%Effect of cerebral microbleeds on cardiac and cerebral vascular events following acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    李晓晴; 毕齐; 王力; 王力峰

    2012-01-01

    目的 研究急性脑梗死合并脑微出血(CMB)患者后期心脑血管事件的发生率和危险因素.方法 将109例急性脑梗死患者分为CMB组38例和无CMB组71例,对其进行前瞻性研究,给予梯度回波T2* WI或磁敏感加权成像,并对患者的临床资料和影像学特点进行分析.平均随访(9.5±3.7)个月.结果 与无CMB组比较,CMB组脑梗死和脑出血两者兼有,单纯脑出血比例明显升高(7.9% vs 1.4%,P<0.05;10.5% vs 0,P<0.01).CMB组共检出CMB 153个.在随访中,16例患者再发脑卒中,包括11例脑梗死,5例脑出血.5例脑出血患者中有3例服用阿司匹林,2例接受抗凝治疗.CMB组有2例脑出血患者的出血部位与CMB部位相同.结论 CMB是脑微小血管病变特征之一;是急性缺血性脑血管病患者后期发生脑出血的危险因素之一;CMB对脑卒中患者长期服用阿司匹林或者抗凝治疗具有重要意义.%Objective To study the incidence and risk factor of cardiac and cerebral vascular events in patients with acute cerebral infarction accompanying cerebral mierobleeds(CMB). Methods One hundred and nine acute cerebral infarction patients were divided into CMB group(n = 38) and non-CMB group (n = 71). The patients underwent gradient echo T2-weighted MRI or magnetic susceptibility-weighted imaging. Their clinical data and imaging characteristics were analyzed. The patients were followed up for 9. 5 + 3. 7 months. Results The proportions of acute cerebral infarction and CMB were significantly higher in CMB group than in non-CMB group(7. 9% vs 1.4%,P<0. 05)10. 5% vs 0,P<0.01).One hundred and fifty-three CMB were detected in CMB group. Of the 16 patients who had relapse of cerebral stroke during the follow-up, 11 had cerebral infarction and 5 had intracerebral hemorrhage(3 were treated with aspirin and 2 received anti-coagulant therapy). The bleeding site was similar to that of CMB in 2 patients of CMB group. Conclusion CMB are one of the

  11. Neurogenesis by Activation of Inherent Neural Stem Cells in the Rat Hippocampus after Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    Bo Zhang; Ren-zhi Wang; Zhi-gang Lian; Yang Song; Yong Yao

    2009-01-01

    Objective To investigate the changes of neural stem cells (NSCs) in the rat hippocampus after cerebral infarction (CI) and to evaluate the neurogenesis caused by the activation of NSCs. Methods CI models of rats were made and rats were assigned to 6 groups: sham-operated, 1 day, 3 days, 7 days, 14 days, and 28 days after CI. The dynamic expression of bromodeoxyuridine (BrdU), polysialylated neural cell adhesion molecule (PSA-NCAM), glial fibrillary acidic protein (GFAP), and neuronal nuclear antigen (NeuN) were determined by immunohistochemistry and immunofluorescence staining. BrdU was used to mark the proliferated NSCs. PSA-NCAM was used to mark the plasticity of activated NSCs. GFAP and NeuN were used to mark the differentiated NSCs. Results Compared with the controls, the number of BrdU+ cells in the hippocampus increased significantly at 1 day after CI (P < 0.05), reached peak at 7 days after CI (P < 0.05), decreased but still elevated compared with the controls at 14 days after CI (P < 0.05), and nearly unchanged at 28 days after CI. The number of BrdU+/PSA-NCAM+ cells increased significantly at 7 days after CI (P < 0.05), reached peak at 14 days after CI (P < 0.05), and decreased but still elevated compared with the controls at 28 days after CI (P < 0.05). The number of BrdU+/PSA-NCAM+ cells was equal to 60% of the number of BrdU+ cells in all the same period. The number of BrdU+/NeuN+ cells in the hippocampus increased significantly at 14 days after CI (P < 0.05) and reached peak at 28 day after CI (P < 0.05). The number of BrdU+/GFAP+cells in the hippocampus nearly unchanged after CI. Conclusion CI can stimulate the proliferation of inherent NSCs, and most proliferated NSCs may differentiate into neurons and represent neural plasticity.

  12. REASSESSMENT OF DEFIBRASE IN TREATMENT OF ACUTE CEREBRAL INFARCTION: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND,PLACEBO-CONTROLLED TRIAL

    Institute of Scientific and Technical Information of China (English)

    The Cooperative Group for Reassessment of Defibras

    2005-01-01

    Objective To evaluate the efficacy and safety of defibrase in patients with acute cerebral infarction by a large sample,multicenter, randomized, double-blind, placebo-controlled clinical trial.Methods Patients with acute cerebral infarction within 12 hours of stroke onset were randomly assigned to receive either an initial intravenous infusion of defibrase 15 U plus normal saline 250 Ml or 250 Ml of normal saline only.Subsequent infusions of defibrase 15 U or placebo (normal saline) were given on the 3rd, 5th, 7th, and 9th day, respectively.Both groups received standard care of acute cerebral infarction. The primary efficacy outcome was functional status(Barthel Index) at 3 months after treatment. Safety outcome were bleeding events and mortality rate. Secondary outcome included Chinese Stroke Scale (CSS) score at 14 days and recurrence rate of stroke at 1 year. Results A total of 1053 patients were enrolled at 46 centers from September 2001 to July 2003, and 527 patients were randomly assigned to receive defibrase and 526 to receive placebo. A similar proportion of patients in both groups completed a full course of treatment. There was a significantly greater proportion of favorable functional status (Barthel Index ≥95) in defibrase group than in placebo group at 3 months (52.2% vs. 42.8%, P < 0.01), and the proportion of dependent functional status (Barthel Index ≤60) was a little lower in defibrase group compared with placebo group(27.7%vs. 32.4%). These differences were more obvious among patients who were treated within 6 hours of stroke onset.Patients in defibrase group had better improvement with respect to CSS score than those in placebo group at 14 days (P <0.05). Recurrence rate of stroke at 1 year was lower in the defibrase group compared with placebo group (6.2% vs. 10.1%,P = 0.053). Patients in defibrase group had higher risk of extracranial bleeding events (4.7%vs. 1.5%, P< 0.01) and a tendency of higher risk of symptomatic intracranial hemorrhage

  13. Absolute Cerebral Blood Flow Infarction Threshold for 3-Hour Ischemia Time Determined with CT Perfusion and 18F-FFMZ-PET Imaging in a Porcine Model of Cerebral Ischemia.

    Science.gov (United States)

    Wright, Eric A; d'Esterre, Christopher D; Morrison, Laura B; Cockburn, Neil; Kovacs, Michael; Lee, Ting-Yim

    2016-01-01

    CT Perfusion (CTP) derived cerebral blood flow (CBF) thresholds have been proposed as the optimal parameter for distinguishing the infarct core prior to reperfusion. Previous threshold-derivation studies have been limited by uncertainties introduced by infarct expansion between the acute phase of stroke and follow-up imaging, or DWI lesion reversibility. In this study a model is proposed for determining infarction CBF thresholds at 3hr ischemia time by comparing contemporaneously acquired CTP derived CBF maps to 18F-FFMZ-PET imaging, with the objective of deriving a CBF threshold for infarction after 3 hours of ischemia. Endothelin-1 (ET-1) was injected into the brain of Duroc-Cross pigs (n = 11) through a burr hole in the skull. CTP images were acquired 10 and 30 minutes post ET-1 injection and then every 30 minutes for 150 minutes. 370 MBq of 18F-FFMZ was injected ~120 minutes post ET-1 injection and PET images were acquired for 25 minutes starting ~155-180 minutes post ET-1 injection. CBF maps from each CTP acquisition were co-registered and converted into a median CBF map. The median CBF map was co-registered to blood volume maps for vessel exclusion, an average CT image for grey/white matter segmentation, and 18F-FFMZ-PET images for infarct delineation. Logistic regression and ROC analysis were performed on infarcted and non-infarcted pixel CBF values for each animal that developed infarct. Six of the eleven animals developed infarction. The mean CBF value corresponding to the optimal operating point of the ROC curves for the 6 animals was 12.6 ± 2.8 mL·min-1·100g-1 for infarction after 3 hours of ischemia. The porcine ET-1 model of cerebral ischemia is easier to implement then other large animal models of stroke, and performs similarly as long as CBF is monitored using CTP to prevent reperfusion.

  14. Absolute Cerebral Blood Flow Infarction Threshold for 3-Hour Ischemia Time Determined with CT Perfusion and 18F-FFMZ-PET Imaging in a Porcine Model of Cerebral Ischemia.

    Directory of Open Access Journals (Sweden)

    Eric A Wright

    Full Text Available CT Perfusion (CTP derived cerebral blood flow (CBF thresholds have been proposed as the optimal parameter for distinguishing the infarct core prior to reperfusion. Previous threshold-derivation studies have been limited by uncertainties introduced by infarct expansion between the acute phase of stroke and follow-up imaging, or DWI lesion reversibility. In this study a model is proposed for determining infarction CBF thresholds at 3hr ischemia time by comparing contemporaneously acquired CTP derived CBF maps to 18F-FFMZ-PET imaging, with the objective of deriving a CBF threshold for infarction after 3 hours of ischemia. Endothelin-1 (ET-1 was injected into the brain of Duroc-Cross pigs (n = 11 through a burr hole in the skull. CTP images were acquired 10 and 30 minutes post ET-1 injection and then every 30 minutes for 150 minutes. 370 MBq of 18F-FFMZ was injected ~120 minutes post ET-1 injection and PET images were acquired for 25 minutes starting ~155-180 minutes post ET-1 injection. CBF maps from each CTP acquisition were co-registered and converted into a median CBF map. The median CBF map was co-registered to blood volume maps for vessel exclusion, an average CT image for grey/white matter segmentation, and 18F-FFMZ-PET images for infarct delineation. Logistic regression and ROC analysis were performed on infarcted and non-infarcted pixel CBF values for each animal that developed infarct. Six of the eleven animals developed infarction. The mean CBF value corresponding to the optimal operating point of the ROC curves for the 6 animals was 12.6 ± 2.8 mL·min-1·100g-1 for infarction after 3 hours of ischemia. The porcine ET-1 model of cerebral ischemia is easier to implement then other large animal models of stroke, and performs similarly as long as CBF is monitored using CTP to prevent reperfusion.

  15. Metabolic Changes in Rats with Photochemically Induced Cerebral Infarction and the Effects of Batroxobin: A Study by Magnetic Resonance Imaging, 1H- and 31P- Magnetic Resonance Spectroscopy

    Institute of Scientific and Technical Information of China (English)

    管兴志; 吴卫平; 匡培根; 匡培梓; 高杨; 管林初; 李丽云; 毛希安; 刘买利

    2001-01-01

    Metabolic changes in rats with photochemically induced cerebral infarction and the effects of batroxobin were investigated 1, 3, 5 and 7 days after infarction by means of magnetic resonance imaging (MRI), 1H- and 31P- magnetic resonance spectroscopy (MRS). A region of T2 hyperintensity was observed in left temporal neocortex in infarction group and batroxobin group 1, 3, 5 and 7 days after infarction. The volume of the region gradually decreased from 1 day to 7 days after infarction. The ratio of NAA/Cho+Cr in the region of T2 hyperintensity in the infarction group was significantly lower than that in the corresponding region in the sham-operated group 3, 5 and 7 days after infarction respectively (P<0.05). Lac appeared in the region of T2 hyperintensity in the infarction group 1, 3, 5 and 7 days after infarction, but it was not observed in the corresponding region in sham-operated group at all time points. Compared with the sham-operated group, the ratios of bATP/PME+PDE and PCr/PME+PDE of the whole brain in the infarction group were significantly lower 1, 3 and 5 days after infarction respectively (P<0.05), and the ratio of bATP/PCr also was significantly lower 1 day after infarction (P<0.05). Batroxobin significantly decreased the volume of the region of T2 hyperintensity 1 and 3 days after infarction (P<0.05), significantly increased the ratio of NAA/Cho+Cr in the region 5 and 7 days after infarction (P<0.05), significantly decreased the ratios of Lac/Cho+Cr and Lac/NAA in the region 5 and 7 days after infarction (P<0.05), and significantly increased the ratios of bATP/PME+PDE and bATP/PCr in the whole brain 1 day after infarction (P<0.05). The results indicated that the infracted region had severe edema, increased Lac and apparent neuronal dysfunction and death, and energy metabolism of the whole brain decreased after focal infarction, and that batroxobin effectively ameliorated the above-mentioned abnormal changes.

  16. Observation on the therapeutic effect of aspirin in combined with ozagrel sodium in the treatment of acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Hong-Jing Shen; Hai-Yan He; Ming-Xuan Dai

    2017-01-01

    Objective:To explore the clinical efficacy of aspirin in combined with ozagrel sodium in the treatment of acute cerebral infarction (ACI).Methods:A total of 120 patients with ACI who were admitted in our hospital from May, 2015 to May, 2016 were included in the study and randomized into the study group and the control group with 60 cases in each group. The patients in the two groups were given cerebral edema alleviating, brain cell protecting, cerebral circulation improving, and blood pressure controlling. The patients in the study group were given aspirin enteric-coated tablets, 0.1 g/time, 1 time/d. On the above basis, the patients in the study group were given ozagrel sodium (80 mg) + 0.9% NaCl (250 mL), ivdrip, 2 times/d. The patients in the two groups were treated for 14 d. The venous blood was extracted 1 d after admission and 14 d after treatment. The full automatic biochemical analyzer was used to detect PLT, PT, TT, FIB, and APTT. The radioimmunoassay was used to detect TXB2 and 6-K-PGF1α. The color Doppler ultrasound was used to detect IMT.Results: PLT, PT, TT, and APTT after treatment were not significantly different from those before treatment (P>0.05), but FIB was significantly reduced, and the reduced degree in the study group was significantly superior to that in the control group (P<0.05). After treatment, TXB2 level in the two groups was reduced, while 6-K-PGF1α was elevated, and those in the study group were significantly superior to those in the control group (P<0.05). After treatment, IMT in the two groups was reduced, and the reduced degree in the study group was significantly superior to that in the control group (P<0.05).Conclusions:Aspirin in combined with ozagrel sodium in the treatment of ACI can effectively inhibit the platelet aggregation, improve the coagulation function and cerebral blood supply, promote the recovery of cerebral nerve function after infarction, and enhance the therapeutic effect; therefore, it deserves to be widely

  17. Heat rate variability and dyssomnia and their correlations to neurological defects in cerebral infarction patients complicated by insomnia A concurrent non-randomized case-control study

    Institute of Scientific and Technical Information of China (English)

    Jianping Chu; Xueli Shen; Jun Fan; Changhai Chen; Shuyang Lin

    2008-01-01

    BACKGROUND: Heart rate variability refers to the beat-to-beat alteration in heart rate. It is usually a slight periodic variation of R-R intervals. Much information of autonomic nerve system balance can be obtained by measuring the heart rate variability of patients. It remains to be shown whether heart rate variability can be used as an index for determining the severity of insomnia and cerebral infarction. OBJECTIVE: This study aimed to analyze the correlation for each frequency spectrum parameter of heart rate variability with an insomnia index, as well as the degree of neurological defects in patients with simple cerebral infarction and cerebral infarction complicated by insomnia. The goal was to verify the feasibility of frequency spectrum parameters for heart rate variability as a marker for insomnia and cerebral infarction. DESIGN: A case-control observation. SETTING: Department of Neurology, First Hospital Affiliated to China Medical University. PARTICIPANTS: Sixty inpatients, and/or outpatients, with cerebral infarction were admitted to the 202 Hospital of Chinese PLA between December 2005 and October 2006, confirmed by CT, and recruited to the study. According to the insomnia condition (insomnia is defined by a Pittsburgh Sleep Quality Index score > 7), the patients were assigned to a simple cerebral infarction group and a cerebral infarction complicated by insomnia group, with 30 subjects in each group. Thirty additional subjects, who concurrently received ex-aminations and were confirmed to not suffer from cerebral infarction and insomnia, were recruited into the control group. Written informed consent was obtained from each subject for laboratory specimens. The pro-tocol was approved by the Hospital's Ethics Committee. METHODS: Following admission, each subject's neurological impairment was assessed with the National Institutes of Health Stroke Scale and Pittsburgh Sleep Quality Index. Heart rate variability of each subject was measured with an

  18. A study on levels of neuropeptide Y, neurotensin motilin and calcitonin gene-reliated peptide in plasma in patients with cerebral infarction and dinical isignificance

    Institute of Scientific and Technical Information of China (English)

    Li Yizhao; Sun Lin; Zhang Dongjun

    2000-01-01

    Objective To explore the relationship between virulent Helicobacter pylori strains infection and cerebral infarction. Method We assessed the prevalence of infection by strains bearing the cytotoxin -associated gene-A(Cag-A),a strong virulence factor ,in 83 patients with cerebral infarction and in 71 age- and sex-matched controls with similar social background. Result Prevalence of Helicobacter pylori infection was significantly higher in patients than in controls(78.3% versus 56.3%,p<0.05),with an odds ratio of 2.8(95%CI,1.46 to 5.36) adjusted for age, sex, main stroke factors. Patients with cerebral infarction also had a higher prevalence of Cag-A-positive strains(45.8% versus 19.7%, P<0.01),with an adjusted odds ratio of 3.43(95%CI 1.5 to 7.24).Conclusion It was suggested that chronic Helicobacter pylori infection, especially Cag-A-positive strains infection is an independent risk factor for cerebral infarction.

  19. The correlation between cognitive function and cerebral white matter lesions/insulin resistance in patients with lacunar infarction:a clinical study of 184 cases

    Institute of Scientific and Technical Information of China (English)

    张琼予

    2013-01-01

    Objective To investigate the correlation between cognitive function and cerebral white matter lesions(WML)/insulin resistance(IR) in patients with stroke.Methods Between May 2011 and October 2011,the clin-ical data of 184 in-patients with lacunar infarction were

  20. Effect of Cell Cycle Inhibitor Olomoucine on Astroglial Proliferation and Scar Formation after Focal Cerebral Infarction in Rats

    Institute of Scientific and Technical Information of China (English)

    MANG Gui-bin; TIAN Dai-shi; XU Yun-lan; XIE Min-jie; WANG Ping; DU Yi-xing; WANG Wei

    2011-01-01

    Background: Astrocytes become reactive following many types of CNS injuries.Excessive astrogliosis is detrimental and contributes to neuronal damage. We sought to determine whether inhibition of cell cycle could decrease the proliferation of astroglial cells and therefore reduce excessive gliosis and glial scar formation after focal ischemia. Methods: Cerebral infarctionmodel was induced by photothrombosis method. Rats were examined using MRI, and lesion volumes were estimated on day 3 post-infarction. The expression of glial fibrillary acidic protein(GFAP) and proliferating cell nuclear antigen(PCNA) was observed by immunofluorescence staining. Protein levels for GFAP, PCNA, Cyclin A and Cyclin B1 were determined by Western blot analysis from the ischemic and sham animals sacrificed at 3,7,30 days after operation. Results:Cell cycle inhibitor olomoucine significantly suppressed GFAP and PCNA expression and reduced lesion volume after cerebral ischemia. In parallel studies, we found dense astroglial scar in boundary zone of vehicle-treated rats at 7 and 30 days. Olomoucine can markedly attenuate astroglial scar formation. Western blot analysis showed increased protein levels of GFAP, PCNA,Cyclin A and Cyclin B1 after ischemia, which was reduced by olomoucine treatment. Conclusion:Our results suggested that astroglial activation, proliferation and subsequently astroglial scar formation could be partially inhibited by regulation of cell cycle. Cell cycle modulation thereby pro-vides a potential promising strategy to treat cerebral ischemia.

  1. Behavioral Disorders in Association with Posterior Callosal and Frontal Cerebral Infarction

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    J. P. Lejeune

    1993-01-01

    Full Text Available Behavioral disorders were a prominent clinical feature after the surgical treatment of an anterior communicating artery aneurysm rupture in a 44-year-old man. Callosal apraxia was associated with an alien hand. The latter remained 1 year after surgery while diagonistic apraxia disappeared after 3 months. Other callosal signs included left agraphia, tactile anomia and auditory suppression. MRI revealed posterior callosal infarction and a right frontal infarct. The association of diagonistic apraxia and alien hand is rarely reported.

  2. Polymorphisms of the coagulation factor Ⅶ gene and its plasma levels in relation to acute cerebral infarction differences in allelic frequencies between Chinese Han and European populations

    Institute of Scientific and Technical Information of China (English)

    康文英; 王鸿利; 熊立凡; 王学锋; 储海燕; 璩斌; 刘湘帆; 尹俊; 段宝华; 王振义

    2004-01-01

    Background Coagulation factor Ⅶ (F Ⅶ) levels in plasma are usually related to ischemic heart disease (IHD) and cerebral infarction shares many of the risk factors related to IHD. Is there any relationship between factor Ⅶ and cerebral infarction? We investigated the relationship between F Ⅶ and acute cerebral infarction and reported genotype frequencies and allelic frequencies of FⅦ gene polymorphisms in the Chinese Han population.Methods We recruited 62 patients with acute cerebral infarction confirmed by magnetic resonance imaging (MRI) from Ruijin Hospital, and 149 age-matched patients clinically free of vascular disease to act as controls. All of them were unrelated, and were from the Chinese Han population. FⅦ coagulant activity (FⅦc) was determined using an clotting assay, activated FⅦ (FⅦa) and FⅦ Ag were assayed using enzyme immunoassay kits. The FⅦ gene polymorphisms to be detected included-401G/T, -402G/A, 5'F7A1/A2, IVS7 and R353Q. 5'F7 and IVS7 were revealed by means of a PCR and direct agarose gel electrophoresis. The rest were examined by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The results showed that FⅦc, FⅦAg and FⅦa were higher in the acute cerebral infarction group than in the control group (P<0.01, P<0.05, P<0.05, respectively). There were no significant differences in the genotype frequencies of FⅦ gene polymorphisms between the two groups. The allelic frequencies in the Chinese Han population were as follows: -401G/T (96.64/3.36), -402G/A (52.01/47.99), 5'F7A1/A2(96.64/3.36), IVS7 H5/H6/H7/H8 (0.34/52.35/46.98/0.34) and R353Q (95.64/4.36). There were significant differences (P<0.01, P<0.001, P<0.001, P<0.001, P<0.001, respectively) in these allelic frequencies between the Chinese Han and European populations.Conclusions The results indicate that increased plasma FⅦ levels may contribute to thrombosis in cerebral infarction. And there was no significant difference

  3. The experience about the th rom bolys is for the cerebral infarction by rT-PA in China

    Institute of Scientific and Technical Information of China (English)

    LI Wei; JIN Jia-xiang; WANG Shao-shi

    2000-01-01

    Object: To introduce our experience of therapy with T-PA in cerebral infarction in China, contraposed to a French document with a series of 100 cases. Methods: Inclusion criteria were same with Trouillas' protocol. Location attached was limited within the territory of internal carotid artery (ICA). The dose of rT-PA was 0.8-0.85mg/Kg. An initial bolus of 10% of the total dose was infused before 90% of the total dose was dropped byvein over 90 minutes. Calcic Nadroparin was continued after 12 hours ofthrombolysis for 10 days. At same time, 20% of Marnitol was administed according to the disorder state. The Scandinavia Stroke Score (SSS) were utilized to evaluate to the neurological function impaired before and after treatment for 24 hours, one week, one month and 3 months and modified Rankin′s Score (mRS) to the capability of life when 90 days after the treatment.Results: (1) Total 16 cases, who come from Shanghai of China, 8 cases of male and 8 cases of female, with 68.44±7.63 years old, were observed. The mean interval is 278.44±73.73 minutes. There are no significant different for baseline SSS, SSS at day 1, Day 7, Day 30 and Day 90 between our data and the data published. (P >0.05) In our group, there are 5 cases (31.25%) with absolute recovery, 4 cases (25%) with remarkable sequels, 2 cases with incapability himself because obvious sequels and 5 cases died in this group. Our study result is no difference with the document observed on Lyon of French. (P >0.05 ) (2) There are 10 cases of baseline SSS<20. In this subgroup, the prognosis is significant difference with 6 cases of subgroup of baseline SSS >20. (P <0.05) The worse the SSS of baseline was, the worse prognosis is. No evidence of hemorrhage in the CT scans. It is important causes that result in bad prognosis: serious heart failure and cerebral infarction with great territory. (3) There are 5 cases died in our group. Among them, 60% died within 72 hours and 2 cases died at 4th day. The area

  4. Netrin-1 rescues neuron loss by attenuating secondary apoptosis in ipsilateral thalamic nucleus following focal cerebral infarction in hypertensive rats.

    Science.gov (United States)

    Liao, S-J; Gong, Q; Chen, X-R; Ye, L-X; Ding, Q; Zeng, J-S; Yu, J

    2013-02-12

    Neurological deficit following cerebral infarction correlates with not only primary injury, but also secondary neuronal apoptosis in remote loci connected to the infarction. Netrin-1 is crucial for axonal guidance by interacting with its receptors, deleted in colorectal cancer (DCC) and uncoordinated gene 5H (UNC5H). DCC and UNC5H are also dependence receptors inducing cell apoptosis when unbound by netrin-1. The present study is to investigate the role of netrin-1 and its receptors in ipsilateral ventroposterior thalamic nucleus (VPN) injury secondary to stroke in hypertensive rats. Renovascular hypertensive Sprague-Dawley rats underwent middle cerebral artery occlusion (MCAO). Continuous intracerebroventricular infusion of netrin-1 (600 ng/d for 7 days) or vehicle (IgG/Fc) was given 24h after MCAO. Neurological function was evaluated by postural reflex 8 and 14 days after MCAO. Then, immunoreactivity was determined in the ipsilateral VPN for NeuN, glial fibrillary acidic protein, netrin-1 and its receptors (DCC and UNC5H2), apoptosis was detected with Terminal deoxynucleotidyl transferase-mediated digoxigenin-dUTP-biotin nick-end labeling (TUNEL) assay, and the expressions of caspase-3, netrin-1, DCC, and UNC5H2 were quantified by western blot analysis. MCAO resulted in the impaired postural reflex after 8 and 14 days, with decreased NeuN marked neurons and increased TUNEL-positive cells, as well as an up-regulation in the levels of cleaved caspase-3 and UNC5H2 protein in the ipsilateral VPN, without significant change in DCC or netrin-1 expression. By exogenous netrin-1 infusion, the number of neurons was increased in the ipsilateral VPN, and both TUNEL-positive cell number and caspase-3 protein level were reduced, while UNC5H2 expression remained unaffected, simultaneously, the impairment of postural reflex was improved. Taken together, the present study indicates that exogenous netrin-1 could rescue neuron loss by attenuating secondary apoptosis in the

  5. The effect of interleukin and matrix metalloproteinase on the vulnerability of carotid atherosclerotic plaque and cerebral infarction

    Directory of Open Access Journals (Sweden)

    HUANG Yan

    2012-06-01

    Full Text Available Objective To investigate the relationship of IL-17, IL-10 and MMP-12 with the vulnerability of carotid atherosclerotic plaque and cerebral infarction. Methods According to clinical stroke event 70 carotid atherosclersis patients were divided into asymptomatic carotid atherosclerosis (ACAS group (n = 35 and acute atherosclerotic cerebral infarction (AACI group (n = 35. The patients were also divided into vulnerable plague (VP group (n = 38 and unvulnerable plague (UVP group (n = 32 by color ultrasonic technique. Normal control group (n = 35 was established. The plasma levels of cytokines were tested by enzyme-linked immunosorbent assay (ELISA. Results Compared with the control group, the concentrations of IL-17, IL-10 and MMP-12 in ACAS group and AACI group were significantly elevated (P = 0.000; P = 0.000, moreover, the concentrations of IL-17 and MMP-12 in AACI group were higher than those in ACAS group (P = 0.000; P = 0.002, respectively. In AACI group, the level of IL-10 was lower than the ACAS group and control group (P = 0.000, for all, whereas, no significant difference of IL-10 level was seen between ACAS group and control group (P = 0.275. In VP group, the concentrations of IL-17 and MMP-12 were higher than those in UVP group (P = 0.000 and 0.014, respectively. In VP group, the level of IL-10 was lower than that in UVP group and control group (P = 0.000, for all, but no significant difference of IL-10 level was seen between UVP group and control group (P = 0.742. Correlation analysis showed, the level of IL-17 was positively correlated with the level of MMP-12 (r = 0.640, P = 0.000, and was negatively correlated with the level of IL-10 (r =-0.430, P = 0.000. The level of MMP-12 was weakly negatively correlated with the level of IL-10 (r =-0.242, P = 0.013. Conclusion IL-17, IL-10 and MMP-12 all participate the pathological process of atherosclerosis and cerebral infarction. The elevated IL-17 and MMP-12 levels and decreased IL-10 level

  6. A Meta-analysis of β-fibrinogen Gene-455G/A Polymorphism and Plasma Fibrinogen Level in Chinese Cerebral Infarction Patients

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    To evaluate the correlation between the β-fibrinogen gene-455G/A polymorphism and cerebral infarction in Chinese population by means of meta-analysis. Methods Genetic association studies on evaluating the β-fibrinogen gene -455G/A polymorphism and cerebral infarction involving Chinese population published before December 2005 were collected from database of PubMed, EMBASE, and CNKI. All the data in literature were abstracted based on the defined selection criteria by two independent investigators. Publication bias was tested by funnel plot and the odd ratios of all studies were combined dependent on the result of heterogeneity test among the individual studies. The software Review Manager (Version 4.2) was used for meta-analysis. Results Eleven studies including 1405 patients and 1600 controls met the selection criteria.There was no publication bias in 11 reviewed studies. Heterogeneity test of reviewed studies showed statistically significant differences (x2=24.58, P=0.006) among the ORs of individual studies. The combined OR of 11 studies of susceptibility to cerebral infarction in -455A allele carriers compared with the -455G/G wild homozygotes was 1.33 (95%CI 1.04-1.71, P=0.02).In the patients with cerebral infarction in 6 studies, the summarized average plasma fibrinogen level of allele A carrier was 0.29g/L (95%CI 0.14-0.44, P=0.0002) higher than that of -455G/G homozygous ones. Conclusions β-fibrinogen gene -455G/A polymorphism might contribute to susceptibility of cerebral infarction in Chinese population; allele A increases the individual susceptibility to the disease.

  7. Degree and prognosis of cerebral infarction with type 2 diabetes mellitus with cerebral infarction%2型糖尿病并发脑梗死神经功能缺损的程度及预后

    Institute of Scientific and Technical Information of China (English)

    王燕

    2016-01-01

    Objective To observe the clinical effect and prognosis of cerebral infarction with type 2 diabetes mellitus,and to investigate the clinical preventive and therapeutic measures.Methods Eighty patients with type 2 diabetes mellitus combined with cerebral infarction were selected as the research objects.According to 1∶1,the patients with non diabetic cerebral infarction were treated as the control group.The patients were treated with oral hypoglycemic agents or insulin.Results There were no significant differences in age or sex between the two groups,the observation group with severe neurologic impairment were 16 cases (20%,16/80),and those in control group were 5 cases(6.25%,5/80),there were significant difference between the two groups (P < 0.05);Treatment invalid 10 cases (12.50%,10/80),which were higher than that in control group(2.50%,2/80)(P < 0.05).Conclusions The clinical symptoms of patients with type 2 diabetes mellitus complicated with acute cerebral infarction is serious,and the prognosis is poor.The blood glucose should be controlled in the normal range,improving the survival rate and the prognosis.Besides strict control of blood sugar,blood lipids,blood pressure,and appropriate anticoagulant,antiplatelet and other comprehensive treatment are all worthy of applicated.%目的 观察2型糖尿病并发脑梗死神经功能的缺损程度及预后,探讨临床防治措施.方法 选择2型糖尿病合并脑梗死患者80例作为研究对象,按照1∶1比例选择同期住院的非糖尿病脑梗死患者作为对照组,入院后均给予综合治疗措施,观察组通过口服降糖药或者注射胰岛素以及饮食控制等措施控制血糖,比较两组患者年龄、性别、神经功能的缺损程度、治疗效果等差异.结果 两组患者年龄、性别比较差异均未见统计学意义,观察组神经功能的缺损程度为重型的有16例(20.00%,16/80),高于对照组的5例(6.25%,5/80) (P <0.05);治疗组无效10

  8. 出血性脑梗死诊疗方式分析%Hemorrhagic Cerebral Infarction Diagnosis Analysis Approach

    Institute of Scientific and Technical Information of China (English)

    李浩涛

    2014-01-01

    Objective To study the analysis of cause of hemorrhagic cerebral infarction and the related factors influencing the prognosis of disease treatment,summarizes the effective way of diagnosis and treatment. Methods Our hospital were retrospectively analyzed clinical data of 90 cases of hemorrhagic cerebral infarction patients,and analyze the related factors to induce hemorrhagic cerebral infarction,the clinical curative effect and bleeding time,bleeding in patients with type relationship with the prognosis of diseases,and so on and so forth. Results The patients' blood sugar levels,whether to impose thrombolysis therapy and infarction in patients with type is an important risk factor of induced hemorrhagic cerebral infarction,this group of al of the patients after targeted individualized treatment,71 cases(78.9%),the person that the il ness get better treatment is invalid in 16 cases(17.8%),the remaining three patients died due to multiple organ failure,and mortality rate of 3.3%;Infarction occurred after 7 d hemorrhage patients and non hematoma in patients with clinical total effective rate(89.5%),(90%) was significantly higher infarction occurred hemorrhage patients(73.1%)and 7 d type hematoma patients(68.3%),contrast differences were statistically significant(P< 0.05). Conclusion Clinical work should be paid attention to during the process of high blood sugar,large area cerebral infarction and thrombolysis treatment of patients with bleeding risk factors of diagnosis and treatment,as far as possible do early diagnosis,early take effective individualized treatment,is helpful for improving the prognosis of patients,reduce mortality.%目的:探讨分析诱发出血性脑梗死以及影响疾病治疗预后的相关因素,总结有效的诊疗方式。方法回顾性分析我院收治的出血性脑梗死90例患者临床资料,分析诱发出血性脑梗死的相关因素、临床治疗疗效以及患者出血时间、出血类型与疾病预后的关系等情

  9. Correlation between myelin basic protein contents and cerebral parenchyma damages in cerebral infarction patients%脑梗死患者血清髓鞘碱性蛋白含量与脑实质损害的相关性

    Institute of Scientific and Technical Information of China (English)

    张国元; 王晓明; 唐中; 郭晓兰; 龙存国; 廖涛

    2004-01-01

    目的:通过检测脑梗死患者及正常人的血清髓鞘碱性蛋白(myelin basic protein,MBP)的含量,探讨脑梗死患者血清髓鞘碱性蛋白含量与脑实质损害的相关性.方法:采用双抗体夹心酶联免疫吸附法对32位正常人及30例脑梗死患者血清MBP含量进行了检测.结果:脑梗死患者和对照组血清其MBP含量分别为(5.63±3.56),(1.10±0.45)μg/L,差异有极显著性(t=7.145,P<0.001),且血清MBP含量与脑梗死体积有一定的关系.结论:脑梗死时血清MBP含量明显升高,且与脑实质损害程度有一定的关系.%AIM: To discuss the correlation between myelin basic protein(MBP) contents and cerebral parenchyma damages in cerebral infarction patients through the assay of MBP contents in both cerebral infarction patients and healthy subjects.METHODS: The MBP serous contents of 32 healthy subjects and 30 cerebral infarction patients were detected by double-antibody-filling ELISA.RESULTS: The serous MBP contents of healthy subjects and cerebral infarction patients were(5.63 + 3.56) and(1.10 + 0.45) μg/L respectively.There was significance between the patient group and the control group ( t = 7. 145, P < 0. 001 ) . There was a certain relationship between the serous MBP content and the volume of cerebral infarct area.CONCLUSION: Serous MBP content markedly increases in cerebral infarction patients, and moreover, there is a certain relationship with the severity of cerebral parenchyma damage.

  10. Hyperlexia and ambient echolalia in a case of cerebral infarction of the left anterior cingulate cortex and corpus callosum.

    Science.gov (United States)

    Suzuki, Tadashi; Itoh, Shouichi; Hayashi, Mototaka; Kouno, Masako; Takeda, Katsuhiko

    2009-10-01

    We report the case of a 69-year-old woman with cerebral infarction in the left anterior cingulate cortex and corpus callosum. She showed hyperlexia, which was a distinctive reading phenomenon, as well as ambient echolalia. Clinical features also included complex disorders such as visual groping, compulsive manipulation of tools, and callosal disconnection syndrome. She read words written on the cover of a book and repeated words emanating from unrelated conversations around her or from hospital announcements. The combination of these two features due to a focal lesion has never been reported previously. The supplementary motor area may control the execution of established subroutines according to external and internal inputs. Hyperlexia as well as the compulsive manipulation of tools could be interpreted as faulty inhibition of preexisting essentially intact motor subroutines by damage to the anterior cingulate cortex reciprocally interconnected with the supplementary motor area.

  11. Cerebral tubercular thrombophlebitis presenting as venous infarct: Magnetic resonance imaging and pathologic correlation

    Directory of Open Access Journals (Sweden)

    Sandhya Mangalore

    2014-01-01

    Full Text Available Central nervous system involvement by tuberculosis to produce basal meningitis, hydrocephalus, arteritis and infarcts is well-known, the brunt of the pathology being borne by the arterial vasculature to produce neurological sequelae. However, tuberculous thrombophlebitis causing venous infarction is exceedingly rare. We present imaging and pathological features of two autopsy proven cases of tuberculous thrombophlebitis with venous infarcts involving superficial venous system in one and deep venous system in the other. This is the first study presenting radiopathologic correlation of this rare complication. Tuberculous thrombophlebitis should be suspected if basal exudates and multiple white matter T2 hyperintensities are seen on neuroimaging and the imaging protocol should include both magnetic resonance arteriogram and venogram.

  12. CT Analysis of 27 Neonatal Cases with Cerebral Infarction%新生儿脑梗死27例CT分析

    Institute of Scientific and Technical Information of China (English)

    汪兴龙; 胡必富; 罗洪云; 刘长华; 夏玉明; 严君

    2015-01-01

    目的:分析新生儿脑梗死的临床和CT表现,提高其诊断与鉴别诊断水平。方法回顾性分析27例新生儿脑梗死的临床和CT资料。结果左侧脑梗死15例,占55.6%,右侧6例,占22.2%,双侧6例,占22.2%;发生于顶枕叶20例,占74.1%;大脑中动脉供血区受累25例,占92.6%;CT表现呈底朝外的楔形或扇形低密度,灰白质同时受累,病灶边缘部分清楚,病变区脑沟变浅或消失,周围水肿较轻,中线结构轻度移位。结论新生儿脑梗死临床表现无特异性, CT检查是诊断新生儿脑梗死的重要手段。%Objective To analyze the clinical and CT manifestations of neonatal cerebral infarction, and to improve the level of diagnosis and differential diagnosis of neonatal cerebral infarction.Methods Retrospective analyze the clinical and CT data of 27 cases with neonatal cerebral infarction.Results There were 15 cases of cerebral infarction located on the left hemicerebrum (55.6%); 6 cases located on the right hemicerebrum (22.2%); 6 cases located on bilateral hemicerebrum (22.2%). 20 lesions were in occipital lobe (74.1%); Middle cerebral arteries were involved in 25 lesions (92.6%). In the CT images, the lesions were shown as low density wedge or sector shapes with bottom outlying, with gray matter affected at the same time. The edges of the lesions were clear, with the brain ditch shoaled or disappeared. The peripheral edema was lighter. The midline structures were slightly shifted.Conclusion The clinical manifestations of neonatal cerebral infarction were lack of speciifcity, and CT examination is an important method for diagnosis of neonatal cerebral infarction.

  13. 脑出血与脑梗死并发腹泻发生率的临床研究%Clinical Comparison of Incidence of Diarrhea between Cerebral Hemorrhage and Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    黄微; 李劲涛; 戴萍

    2014-01-01

    目的:分析比较脑出血与脑梗死患者并发腹泻的发生率.方法对云南省第三人民医院住院期间的147例脑出血患者与142例脑梗死患者发生腹泻者进行发生率的统计,并观察腹泻发生的时间.结果脑出血患者发生腹泻率为36.05%,脑梗死患者发生腹泻率16.91%,脑出血并发腹泻率高于脑梗死患者.结论脑出血并发腹泻率高于脑梗死患者,可能是脑出血患者颅高压的因素较脑梗死更显著,引起应急状态下免疫功能下降,再加上卧床易并发感染等并发症,进食障碍致低蛋白血症加重肠粘膜水肿,长期用抗生素导致肠道菌群失调等因素较脑梗死更显著,故而腹泻的发生率较高.%Objective To analyze and compare the incidence of diarrhea between cerebral hemorrhage and infarction. Method We observed and compared the time when diarrhea occurred in both 147 cases of cerebral hemorrhage patients and 142 cases of cerebral infarction patients by using statistical methods. Result The incidence of diarrhea in former group was 36.05%, and that of latter was 16.91%. Conclusions The incidence in patients with diarrhea of cerebral hemorrhage was markedly higher than that of patients with cerebral infarction. This may attribute to the higher intracranial pressure in cerebral hemorrhage patients than that of cerebral infarction ones. The complications of reduction of immune function,intestinal infection and hypoproteinemia may be the other factors resulting in the higher incidence of diarrhea in cerebral hemorrhage patients than that of cerebral infarction ones.

  14. Focal brain ischemia in the rat: methods for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries.

    Science.gov (United States)

    Brint, S; Jacewicz, M; Kiessling, M; Tanabe, J; Pulsinelli, W

    1988-08-01

    This article describes a 3-year experience with focal neocortical ischemia in three rat strains. Multiple groups of adult Wistar (n = 50), Fisher 344 (n = 31), and spontaneously hypertensive (n = 72) rats were subjected to permanent occlusion of the distal middle cerebral (MCA) and ipsilateral common carotid arteries (CCA). Twenty-four hours later the animals were killed, and frozen brain sections were stained with hematoxylin and eosin to demarcate infarcted tissue. The infarct volume for each section was quantified with an image analyzer, and the total infarct volume was calculated with an iterative program that summed all interval volumes. Neocortical infarct volume was the largest and most reproducible in the spontaneously hypertensive rats (SHR). Statistical power analysis to project the numbers of animals necessary to detect a 25 or 50% change in infarct volume with alpha = 0.05 and beta = 0.2 revealed that only the SHR model was practical in terms of requisite animals: i.e., less than 10 animals per group. Tandem occlusion of the distal MCA and ipsilateral CCA in the SHR strain provides a surgically simple method for causing large neocortical infarcts with reproducible topography and volume. The interanimal variability in infarct volume that occurs even in the SHR strain dictates that randomized, concomitant controls are necessary in each study to ensure the accurate assessment of experimental manipulations or pharmacologic therapies.

  15. Influence of mild hypothermia on vascular endothelial growth factor and infarct volume in brain tissues after cerebral ischemia in rats

    Institute of Scientific and Technical Information of China (English)

    Fei Ye; Gangming Xi; Biyong Qin; Shifeng Wang; Chengyan Li

    2006-01-01

    BACKGROUND: It has been demonstrated that mild hypothermia has obvious protective effect on both whole and local cerebral ischemia. However, the definite mechanism is still unclear for the brain protection of mild hypothermia on cerebral edema, inhibiting inflammatory reaction, stabilizing blood brain barrier, etc.OBJECTIVE: To investigate the effect of mild hypothermia on the expression of vascular endothelial growth factor and the infarct volume after cerebral ischemia in rats, and analyze the brain protective mechanism of mild hypothermia.DESIGN: A randomized grouping and controlled animal trial.SETTING: Department of Neurology, People's Hospital of Yunyang Medical College.MATERIALS: Twenty adult male SD rats of clean degree, weighing (250±30) g, were provided by the animal experimental center, School of Medicine, Wuhan University. The kits for SP immunohistochemistry were purchased from Beijing Zhongshan Golden Bridge Biotechnology Co., Ltd.METHODS: The experiments were carried out in the laboratory of Department of Neurology, Renmen Hospital of Wuhan University from May to July 2005. ① The 20 rats were divided randomly into normal temperature group (n =10) and mild hypothermia group (n =10). Models of permanent middle cerebral artery occlusion were established with modified nylon suture embolization. The rats were assessed with the Longa standards: O point for without nerve dysfunction; 1 for mild neurological deficit (fore claws could no extend completely); 2 for moderate neurological deficit (circling towards the affected side); 3 for severe neurological deficit (tilting towards the affected side); 4 for coma and unconscious; 1 -3 points represented that models were successfully established. The rats of the normal temperature group were fed at room temperature, and those in the mild hypothermia group were induced by hypothermia from 2 hours postoperatively, and the rectal temperature was kept at 34-35 ℃ for 72 hours. ② Measurement of infarct volume

  16. Metabolic and neurological patterns in chronic cerebral infarction: a single-voxel {sup 1}H-MR spectroscopy study

    Energy Technology Data Exchange (ETDEWEB)

    Kamada, K. [Department of Neurosurgery, Hokkaido University School of Medicine, North-15, West-7, Kita-Ku, Sapporo 060 (Japan); Houkin, K. [Department of Neurosurgery, Hokkaido University School of Medicine, North-15, West-7, Kita-Ku, Sapporo 060 (Japan); Iwasaki, Y. [Department of Neurosurgery, Hokkaido University School of Medicine, North-15, West-7, Kita-Ku, Sapporo 060 (Japan); Abe, H. [Department of Neurosurgery, Hokkaido University School of Medicine, North-15, West-7, Kita-Ku, Sapporo 060 (Japan); Kashiwaba, T. [Kashiwaba Neurosurgical Hospital, Hokkaido (Japan)

    1997-08-01

    The details of brain metabolism in chronic cerebral infarcts have not been clarified. Using proton MR spectroscopy ({sup 1}H-MRS) at 1.5 T, we measured biochemical changes in 16 patients with large infarcts involving the motor cortex in the chronic phase (median 293.9 days) and related the findings to clinical data. Localised spectra were obtained using point-resolved spectroscopy, with an echo time of 270 ms. Regions of interest were placed on the frontal lobe, including the precentral gyrus and central sulcus. Motor function was assessed by the manual muscle power test at the time of the {sup 1}H-MRS study. Only three patients with severe paresis had no signal in the lesions and a lactate signal was obtained in 13 cases. N -acetyl aspartate (NAA) was observed in 4 cases with recanalisation of an occluded vessel. Motor function correlated strongly with the NAA/choline-containing compounds (Cho) ratio (P < 0.01) and lactate/Cho ratio (P < 0.01). We found various metabolic patterns, reflecting residual neurological function. (orig.). With 4 figs., 2 tabs.

  17. Clinical study of diabetic cerebral hemorrhagic infarction and cerebral hemorrhagic infarction without diabetic%2型糖尿病合并出血性脑梗死的相关性研究

    Institute of Scientific and Technical Information of China (English)

    饶琦; 桂绍高; 朱晓钢

    2016-01-01

    Objective To study clinical characteristics on diabetic cerebral hemorrhagic infarction and cerebral hemorrhagic infarction without diabetic. Methods The changes of blood glucose,total cholesterol (TC),triglyceride (TG),high-density lipopro-tein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),uric acid(UA) in 55 patients with diabetes complicated with HI and 60 patients without diabetes complicated with HI were analyzed retrospective. The relationship between the degree of neu-rological deficit,the size of infarction and the size of bleeding area between the two groups were compared. Results Blood glu-cose,TC,TG,LDL-C,UA in the diabetes complicated with the non-diabetes complicated with HI group (P<0.05),while the HDL-C decreased significantly (P<0.05),The degree of neurological deficit,the size of infarction and the size of bleeding area complica-tions and mortality in the diabetes complicated with HI group were significantly higher than those in the non-diabetes complicated with HI group. Conclusion The patients with diabetes complicated with HI often has abnormal fat metabolism because of Glucose metabolism disorders. When HI occurred,the size of infarction might increase,and the symptom and glucose metabolism disorder may be aggravated. So The prognosis in patients with diabetics complicated with HI is poor.%目的:探讨糖尿病出血性脑梗死与非糖尿病出血性脑梗死患者的临床特点。方法回顾性分析115例出血性脑梗死患者,分为糖尿病HI组55例及非糖尿病HI组60例,对比两组空腹血糖(GLU)、血清总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-C),低密度脂蛋白(LDL-C),血清尿酸(UA),以及两组梗死灶及出血灶稳定后神经功能损害、梗死面积及出血面积进行对比研究。结果糖尿病HI组患者TC、TG、LDL-C、UA均显著高于非糖尿病HI组患者(P<0.5),糖尿病HI组患者HDL-C低于非糖尿病出血性脑梗死组患者(P<0.5),

  18. Clinical research on cognitive function impairment after acute cerebral infarction%急性脑梗死后认知功能障碍的临床研究

    Institute of Scientific and Technical Information of China (English)

    严春梅; 李燕

    2011-01-01

    Objective To analyze the(ACI) relationship between infarction sites and cognitive impairment after acute cerebral infarction.Methods A total of 134 patients with first ACI and 50 healthy control subjects matched with age, sex and education level were selected.All subjects were assessed with mini-mental state examination (MMSE), clinical memory scale ( CMS), verbal fluency test ( VFT), clock drawing task ( CDT), Barthel index (B1) assessment,Haehinski ischemic scale (HIS), Hamilton depression scale (HAMD).All patients and healthy control subjects were examined with event-related potentials (ERP) P300 test.The relationship between Results of above-mentioned neuropsychological assessment and P300 findings were compared and analyzed in accordance with the neuroimaging type of cerebral infarction.Results 1.There was statistical significance in differences of scores of MMSE, CMS, VFT, CDT between middle infarction and lacunar infarction ( P 0.05 ).2.In middle infarction and small infarction subgroups: the scores of MMSE, CMS in frontal lobe infarction and temporal lobe infarction were lower than those in basal ganglia infarction, parietal lobe infarction and occipital lobe infarction; the scores of MMSE, CMS in basal ganglia infarction were lower than those in parietal lobe infarction and occipital lobe infarction, all had statistically significant differences( P 0.05 ).Conclusion The location of cerebral infarction is closely related with cognitive function impairment after ACI.%目的 探讨并分析梗死灶部位与急性脑梗死(ACI)后认知功能障碍的关系.方法 选取134例ACI患者(ACI组)和100例健康人(对照组)进行简易精神状态检查表(MMSE)、临床记忆量表(CMS)、词语流畅性测验(VFT)、画钟测验(CDT)等评定,并行F300检查,将神经心理学量表评定结果及P300检查结果按照脑梗死的影像学分型进行对比研究.结果 1.中梗死与腔隙性梗死MMSE、CMS、VFT、CDT评分差异均有统计学意义(P0

  19. Transcortical mixed aphasia due to cerebral infarction in left inferior frontal lobe and temporo-parietal lobe

    Energy Technology Data Exchange (ETDEWEB)

    Maeshima, S.; Matsumoto, T.; Ueyoshi, A. [Department of Physical Medicine and Rehabilitation, Wakayama Medical University, Wakayama (Japan); Toshiro, H.; Sekiguchi, E.; Okita, R.; Yamaga, H.; Ozaki, F.; Moriwaki, H. [Department of Neurological Surgery, Hidaka General Hospital, Wakayama (Japan); Roger, P. [School of Communication Sciences and Disorders, University of Sydney, Sydney, NSW (Australia)

    2002-02-01

    We present a case of transcortical mixed aphasia caused by a cerebral embolism. A 77-year-old right-handed man was admitted to our hospital with speech disturbance and a right hemianopia. His spontaneous speech was remarkably reduced, and object naming, word fluency, comprehension, reading and writing were all severely disturbed. However, repetition of phonemes and sentences and reading aloud were fully preserved. Although magnetic resonance imaging (MRI) showed cerebral infarcts in the left frontal and parieto-occipital lobe which included the inferior frontal gyrus and angular gyrus, single photon emission CT revealed a wider area of low perfusion over the entire left hemisphere except for part of the left perisylvian language areas. The amytal (Wada) test, which was performed via the left internal carotid artery, revealed that the left hemisphere was dominant for language. Hence, it appears that transcortical mixed aphasia may be caused by the isolation of perisylvian speech areas, even if there is a lesion in the inferior frontal gyrus, due to disconnection from surrounding areas. (orig.)

  20. 老年急性心肌梗死合并脑梗死患者临床特点分析%Clinical analysis of elderly patients with acute myocardial infarction complicated with cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    张雅婷; 王丽

    2014-01-01

    目的:探讨老年急性心肌梗死合并脑梗死患者的临床特点。方法选取该院2008年6月至2013年6月收治的79例老年急性心肌梗死合并脑梗死患者,按预后分为死亡组和存活组,对两组患者的患病危险因素、临床表现、心肌梗死部位、脑梗死部位及确诊脑梗死时间进行临床观察。结果两组患者患病危险因素比较,差异无统计学意义(P>0.05),死亡组患者意识障碍、低血压、脑梗死确诊时间与存活组比较,差异均有统计学意义(P<0.05)。死亡组患者心前壁和脑干梗死比例高于存活组,差异有统计学意义(P<0.05)。结论老年急性心肌梗死合并脑梗死临床表现复杂,急性前壁心肌梗死患者应及早预防脑梗死的发生,早期确诊能明显改善患者预后。%Objective To investigate the clinical characteristics of elderly patients with acute myocardial infarction (A-MI) complicated with cerebral infarction. Methods A total of 79 elderly patients with AMI complicated with cerebral infarction , who were received in the hospital from June 2008 to June 2013,were divided into the death group(n=49) and survival group(n=30) according to prognosis. The risk factors,clinical manifestations,the site of myocardial infarction,the site of cerebral infarction site and confirmed infarction time of the two groups were observed clinically. Results There was no statistically significant dif-ference on risk factors between the two groups ,but the difference on disturbance of consciousness ,hypotension and confirmed in-farction time had statistical significance(P<0.05). The portion of anterior wall of heart and brainstem infarction in the death group was higher than that in the survival group(P<0.05). Conclusion The clinical manifestations of elderly patients with AMI compli-cated with cerebral infarction are complex ,it is necessary for the patients with acute anterior myocardial infarction to prevent the

  1. Correlations between MRI and Cognitive Changes during Acute to Rehabilitation Phase of Cerebral Infarction%脑梗死患者急性期-康复期认知变化与脑MRI分析

    Institute of Scientific and Technical Information of China (English)

    徐晓云; 高伟明; 朱雯霞; 沈伟文

    2002-01-01

    Objective: To examine correlations between MRI and cognitive changes associated with cerebral infarction. Methods: Using HDS-R and Senior Cognitive Scale, we assessed 101 patients with cerebral infarction during acute to rehabilitation phase. The results were compared with their MRI. Results: At 3 weeks after onset, cognitive impairment was found in 70.3% of the patients. At 6 months after onset, 10% recovered to normal, 35.6% improved, 22.8% worsened, and 42.5% met the criteria of dementia. During acute phase, infarction focus and leukoaraiosis (LA) were related to cognitive impairment P<0.05). During rehabilitation phase, cognitive impairment was related to LA.Conclusion:Cerebral infarcti on results in significant cognitive impairment. LA is the major cause of cognitive impairment associated with cerebral infarction in rehabilitation.

  2. Study on red cell immune function in patients with arteriosclerotic cerebral infarction%动脉粥样硬化性脑梗死患者红细胞免疫功能变化特点

    Institute of Scientific and Technical Information of China (English)

    赵永波; 王乔树; 郭春妮

    2003-01-01

    @@ INTRODUCTION Role of red cell immune adhererence(RCIA) in diseases received more attention in recent years[1 -3]. Since 1992, we investigated RCIA and its relation with arteriosclerotic cerebral infarction[4].

  3. Cerebral infarct in children aged zero to fifteen years Infarto cerebral em crianças de zero a quinze anos de idade

    Directory of Open Access Journals (Sweden)

    Thelma Ribeiro Noce

    2004-03-01

    Full Text Available Cerebral infarcts in children present peculiar characteristics either due to their diversity of causes or due to the unknown nature of the causes. The etiologies of cerebral infarct were reviewed in children from zero to 15 years old, attended at a tertiary hospital, in Ribeirão Preto (Brazil, from 1990 to 1997, adopting the modified Trial of ORG 10172 in Acute Stroke Treatment (TOAST criteria of classification; 1 - Atherosclerosis in large arteries; 2 - Cardioembolic; 3 - Occlusion of small vessels; 4 - Other etiologies; 5 - Undetermined cause. Thirty-nine children were included, 18 males and 21 females, aged 2 months to 15 years, mean age 5.67. The largest group, N=22 (56.4%, included children with ''other etiologies'', 7 of them aged under two years. The most common etiology was dehydration and septic shock leading to brain hypoperfusion and watershed infarcts. Nine (23% children had ''Undetermined etiology'', 7 (17,9% cardioembolic subtype and none had atherosclerosis. Laboratory improvement is needed for the large number of patients without a defined cause, and the high proportion of children with dehydration in the group with a determined cause emphasizes the need for preventive health actions among infants and children.Infartos cerebrais em crianças apresentam peculiaridades, como grande variedade de causas e alta freqüência sem etiologia definida. Foram revistos os diagnósticos etiológicos em crianças de zero a 15 anos, atendidas durante o ictus e com imagens cerebrais sugestivas de infarto, entre 1990 e 1997 em hospital terciário de Ribeirão Preto (SP. Adotou-se o critério de classificação modificado do Trial of ORG 10172 in Acute Stroke Treatment (TOAST: 1 - Arterioesclerose de grandes artérias, 2 - Cardioembólico, 3 - Oclusão de pequenos vasos, 4 - Outras etiologias, 5 - Não determinada. Trinta e nove crianças foram incluídas, 18 do sexo masculino e 21 do feminino, com idade variando entre 2 meses e 15 anos e m

  4. Responses of serum inflammatory factor high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha in elderly males with cerebral infarction Non-randomized concurrent control

    Institute of Scientific and Technical Information of China (English)

    Guiping Jiao; Xinjie Tan; Zhiliu Yuan; Chunling Li; Jing Wang; Wen Mo

    2008-01-01

    BACKGROUND: Cerebral infarction is poorly treated due to neuronal necrosis and secondary pathophysiological changes; for example, free radical production and inflammatory reactions.OBJECTIVE: To detect the levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor nccrosis factor-α (TNF-α) in elderly males with cerebral infarction.DESIGN: Non-randomized current control study.SETTING: Cadre Medical Department, Guizhou Provincial People's Hospital.PARTICIPANTS: Forty elderly males (65-89 years old) with cerebral infarction were selected from Cadre Medical Department, Guizhou Provincial People's Hospital from February 2004 to December 2006. All patients met the diagnostic criteria of cerebral infarction modified at the 4th National Cerebrovascular Disease Academic Meeting, and were diagnosed on the basis of CT or MRI tests. Furthermore, 35 elderly male inpatients (65-87 years old) without cerebral infarction were selected as the control group. Included subjects provided confirmed consent and did not have heart disease, diabetes mellitus, lipid disorder, acute trauma, infection, rheumatism, or other inflammatory diseases. The study was approved by the local ethics committee. There were no significant differences in age, blood pressure, and lipid levels between the cerebral infarction group and the control group (P>0.05), and this suggested that the baseline data of both groups were comparable.METHODS: Fasting venous blood was drawn from cerebral infarction patients 24 hours after cerebral infarction attack and from control subjects 24 hours after hospitalization. A latex-enhanced immunoturbidimetric assay and an enzyme-linked immunosorbent assay were used to detect the levels of hs-CRP, IL-6, and TNF-α in the serum.MAIN OUTCOME MEASURES: The levels of hs-CRP, IL-6, and TNF-α in the serum in both groups.RESULTS: Forty cerebral infarction patients and thirty-five control subjects were included in the final analysis without any loss

  5. Evaluation of pharmacological efficacy of anti-edema agents in a rat cerebral infarction model by MRI image analysis

    Energy Technology Data Exchange (ETDEWEB)

    Izumi, Yoshio; Haida, Munetaka; Kurita, Daisaku; Shinohara, Yukito [Tokai Univ., Isehara, Kanagawa (Japan). School of Medicine; Sugiura, Takeo

    1997-04-01

    We investigated the efficacy of drugs used to treat brain edema in a rat acute cerebral infarction model by MRI image analysis. Twenty-six Sprague-Dawley rats were anesthetized with halothane, and the right middle cerebral artery was permanently occluded via a transvascular approach using a nylon 2-0 suture. At 24 hours after the occlusion, axial T{sub 2}-weighted MRI images were taken before and 2 hours after intraperitoneal administration of a test drug. After the administration of 1.7 g/kg glycerol (n=9), 3.3 g/kg mannitol (n=9) or 17 mg/kg furosemide (n=8), the high intensity area (HIA) in the whole brain amounted to 92% (p<0.01), 94% (p=0.07), or 95% (p=0.03), respectively as compared to the corresponding HIA before administration. The HIA in the cerebral cortex amounted to 87% (p<0.01), 89% (p=0.03), or 98% (p=0.47), and that in the striatum to 102%, 106%, or 87% (p<0.05), respectively. The signal intensity change (before{yields}after) was 54{yields}49 (p<0.01), 54{yields}50 (p<0.01), or 55{yields}54 in the left side normal cortex; 102{yields}97 (p<0.0l), 100{yields}98, or 98{yields}97 in the injured side cortex; and 100{yields}93 (p<0.0l), 94{yields}88 (p=0.03), or 94{yields}94 in the injured side striatum, respectively. Improvement of edema by the drugs was observed as a reduction in HIA and a decrease in signal intensity on MRI, and the changes were significant in the case of administration of each of glycerol, mannitol and furosemide. (author)

  6. 丹奥对脑梗死神经功能恢复的近期疗效观察%To observe recent treating effects of Dan'ao on the nerve function recovery of cerebral infarction patients

    Institute of Scientific and Technical Information of China (English)

    刘惠民; 刘川

    2001-01-01

    @@Backgroud:The cerebral infarction is one of the major reasons which cause deathes or disabilities in the aged.The initiaion factors of cerebral infarction were increased aggregation of the platelets and released thromboxane synthase(TXA2).Tehenzyme caused the aggregation of the platelets and the constration of blood vessels and so caused the formation of thrombus.Dan'ao(Ozagren sodium)may inhibit the synthesis of thrombus synthase,inhibit synthesis of platease and facilitate production of Prostaglandin synthase.

  7. Cerebral infarction on 99mTc-MDP SPECT/CT imaging.

    Science.gov (United States)

    Guo, Jia; Hu, Shuang; Wang, Haitao; Kuang, Anren

    2013-11-01

    A 70-year-old man with lung cancer underwent whole-body MDP bone scintigraphy to evaluate bone metastases that showed marked tracer uptake in the right side of the head, suggestive of skull metastasis. SPECT/CT imaging was performed for further evaluation. The SPECT images demonstrated increased MDP activity in the region of the brain perfused by the right middle cerebral artery. On CT images, there was a large hypoattenuation area corresponding to elevated MDP accumulation. At the same day, magnetic resonance angiography of the brain revealed occlusion of the right middle cerebral artery.

  8. Relationship between glutathione and malonaldehyde levels in erythrocytes and the deformation index of erythrocyte in patients at various periods following acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Dongjun Zhang; Guangrun Xu; Zhaofu Chi; Bingxia Shi

    2006-01-01

    BACKGROUND: Glutathione, as an in vivo free radical scavenger, plays an important role in the anti-oxidation defense mechanism in patients with acute cerebral infarction.OBJECTIVE: To observe the relationship between the levels of glutathione (GSH) and malonaldehyde (MDA), the metabolite of lipid peroxidation, in erythrocyte and deformation index of erythrocyte in patients at various periods following acute cerebral infarction.DESIGN : Controlled observation.SETTING: Qilu Hospital of Shandong University and Institute of Cerebrovascular Disease of Qingdao Medical College.PARTICIPANTS: We chose 98 inpatients with acute cerebral infarction from Department of Neurology, Qilu Hospital of Shandong University from January to December 2000 , serving as cerebral infarction group, including 50 male and 48 female , with mean age of (62±7)years. There were 23 cases found on the 1st day after onset; 25 cases on the 3rd day after onset; 25 cases on the 7th day after onset; 25 cases on the 14th days after onset, and they were all confirmed by craniocerebral CT or MRI. Another 30 homeochronous inpatients with neurosis, cervical syndrome, lumbar intervertebral disc herniation and motor neuron disease were chosen as control group, including 20 male and 10 female, with mean age of (52±8)years . There was no significant difference in age and gender distribution between two groups (P > 0.05). Patients in the two groups were informed of detected index.METHODS: ①Ulnar venous blood was chosen from the patients who were fasted on the 1st, 3rd, 7th and 14th days after onset. Deformation index of erythrocyte was measured with BL88-CKX laser diffraction erythrocyte deformeter and photographing was performed. GSH level in erythrocyte was measured with DTNB assay introduced by Beu-tler. MDA level in erythrocyte was measured with modified thiobarbituric acid colorimetric method. ②At each sample collecting , according to the criteria accepted by the Fourth National Conference of

  9. Thrombotic thrombocytopenic purpura: MRI demonstration of persistent small cerebral infarcts after clinical recovery

    Energy Technology Data Exchange (ETDEWEB)

    Gruber, O.; Cramon, D.Y. von [Day-Care Clinic for Cognitive Neurology, University of Leipzig (Germany); Max Planck Institute of Cognitive Neuroscience, Leipzig (Germany); Wittig, I. [Day-Care Clinic for Cognitive Neurology, University of Leipzig (Germany); Wiggins, C.J. [Max Planck Institute of Cognitive Neuroscience, Leipzig (Germany)

    2000-08-01

    Abnormalities in the brain of patients with thrombotic thrombocytopenic purpura (TTP) are infrequent on MRI, often reversible and mainly limited to symptomatic stages of the disease. We report a case in which high-resolution MRI demonstrated multiple persistent small cortical infarcts after clinical remission. High-resolution MRI investigations may detect clinically latent but permanent brain damage, and complement clinical judgement in guiding therapeutic decisions. (orig.)

  10. Differential expression of 114 oxidative stressrelated genes in peripheral blood mononuclear cells of acute cerebral infarction patients A gene microarray experiment

    Institute of Scientific and Technical Information of China (English)

    Jing Yang; Fei Zhong; Mingshan Ren; Jiangming Zhao

    2010-01-01

    Previous studies have focused on the analysis of single or several function-related genes in oxidative stress;however,little information is available regarding altered expression of oxidative stress-related genes in the process of ischemia-reperfusion injury from microarray experiments.The aim of the present study was to investigate the changes in cell oxidative stress-and toxicity-related gene expression utilizing microarray screening in patients with acute cerebral infarction during cerebral ischemia-reperfusion injury.Of the included 114 genes,expression was significantly upregulated in eight genes,including three heat shock protein-related genes,one oxidative and metabolic stress-related gene,one cell growth arrest/senescence related gene,two apoptosis signal-related genes,and one DNA damage and repair related gene.Expression was significantly downregulated in four genes,including one cell proliferation/cancer related gene,two oxidative and metabolic stress-related genes and one DNA damage and repair related gene.The results demonstrated that cerebral ischemia-reperfusion injury in patients with acute cerebral infarction was affected by many genes including oxidative stress-,heat shock-,DNA damage and repair-,and apoptosis signal-related genes.Therefore,it could be suggested that cerebral ischemia-reperfusion injury may be subjected to complex genetic regulation mechanisms.

  11. Clinical analysis of recurrent cerebral hemorrhage in patients with cerebral infarction complicated with cerebral hemorrhage%合并脑微出血的脑梗死患者再发脑出血临床分析

    Institute of Scientific and Technical Information of China (English)

    魏瑞花

    2016-01-01

    目的:探讨合并脑微出血(CMB)的脑梗死患者再发脑出血的相关因素及预防措施。方法选取急性脑梗死患者124例为研究对象,根据磁共振梯度回波 T2加权成像(GRE-T2*W1)结果分为两组,合并CMB 者42例为研究组,无 CMB 者82例为对照组,比较两组再发脑出血情况及相关因素。结果研究组CMB 在颅内的分布情况为:分布于基底节/丘脑区23个,占54.7%;皮质-皮质下区12个,占28.5%;幕下区7个,占16.7%。再出血发生情况为:基底节/丘脑区11.3%,发生于皮质-皮质下区7.3%,发生于幕下区位0.8%。研究组再出血发生率40.4%,明显高于对照组的10.9%,差异有统计学意义(χ2=11.263,P <0.05)。结论合并 CMB 的脑梗死患者,为再发脑出血的高危人群。通过 GRE-T2*W1及时发现 CMB,可有效指导临床医生合理选择治疗方案,降低脑出血的发生率,改善患者预后。%Objective To investigate the related factors and prevention measures of recurrent intracerebral hemorrhage in cerebral infarction patients with cerebral microbleeds.Methods 124 patients with acute cerebral infarction were divided into two groups according to the GRE -T2 * W1 examination,cerebral microbleeds as control group(n =42),non cerebral microbleeds as observation group(n =82);The recurrence of cerebrahemorrhage and related factors of the two groups were compared.Results In the control group,the distribution of the CMB in intracranial:thalamus -basal ganglia area was 23,accounting for 54.7%;cortical -subcortical area was 12,accounting for 28.5%,under the curtain area was 7,accounting for 16.7%.The incidence of recurrent intracerebral hemorrhage was 1 1 .3 % ,7.3% and 0.8% respectively .The incidence of recurrent intracerebral hemorrhage in the group with CMB(40.4%)was obviously higher than that of without the CMB group(10.9%),the difference was statistically

  12. Classification of Oxfordshire community stroke project assisted by transcranial Doppler ultrasound examination for treating acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Xiaohua Xiao; Jie Situ; Tinghui Li; Shaohong Qiu

    2006-01-01

    BACKGROUND: The early correct diagnosis of acute cerebral infarction (ACI) is very important for choosing therapeutic regimen. The classification of Oxfordshire community stroke project (OCSP) provides guide for easy and rapid diagnosis and choosing therapeutic regimen in clinical practice. But current operation is not satisfied. Only depending on clinical symptoms and body signs do objective evidences lack. Transcranial Doppler ultrasound (TCD) examination may provide hemodynamical evidences for the correct classification of OCSP to some extent. OBJECTIVE: To compare the results of OCSP classification and TCD examination for treating ACI in patients, and analyze the relationship between them as well as the effect of TCD on the correct classification of OCSP. DESIGN: Controlled observation.SETTING: Department of Internal Medicine, Shenzhen Hospital of Prevention and Treatment for Occupational Disease. PARTICIPANTS: Thirty-eight inpatients with ACI including 21 males and 17 females, aged 50 to 81 years, who received treatment in the Department of Internal Medicine, Shenzhen Hospital of Prevention and Treatment for Occupational Disease within 24 hours after onset from October 2002 to October 2005 were involved. The involved inpatients all confirmed to the diagnostic criteria of ACI formulated in the 4th National Cerebrovas- cular Diseases Conference. All the cases received skull computer tomography (CT) or magnetic resonance imaging (MRI) examinations at 24 hours after onset. Those patients who had no obvious infarct focus in skull CT examination within 24 hours after onset were performed re-examination to verify ACI within 72 hours after onset. Informed consents of examination method were obtained from all the patients. METHODS: According to the classification of OCSP, the patients were assigned into 4 subtypes: lacunar infarction (LACI), total anterior circulation infarction (TACI), part anterior circulation infarction (PACI) and posterior circulation infarction

  13. Cardioembolic occlusion of the internal carotid artery presented with infarction in the posterior cerebral artery territory

    Institute of Scientific and Technical Information of China (English)

    XUE Su-fang; JIA Jian-ping

    2010-01-01

    @@ Posterior circulation stroke may rarely be associated with occlusive disease in the anterior circulation, such as in the context of a direct (fetal) origin of the posterior cerebral artery (PCA) from the internal carotid artery (ICA), or in the presence of a persistent trigeminal artery (PTA) or persistent hypoglossal artery (PHA).1,2

  14. Middle cerebral artery occlusion in presence of low perfusion pressure increases infarct size in rats

    DEFF Research Database (Denmark)

    Sillesen, H; Nedergaard, Majken; Schroeder, T;

    1988-01-01

    A model was set up in order to evaluate the importance of hemispheric perfusion pressure when the middle cerebral artery (MCA) is occluded in anaesthetized rats. In 6 animals the internal carotid artery (ICA) was occluded prior to ipsilateral MCA occlusion; in 17 animals the MCA only was occluded...

  15. Concerned about the Risk of Cerebral Infarction Caused by Red Blood Cells 1 Case of Cerebral Infarction Caused by Red Blood Cell%关注红细胞增多症引起脑梗死的风险-红细胞增多症致脑梗死1例

    Institute of Scientific and Technical Information of China (English)

    李辉

    2015-01-01

    目的:探讨红细胞增多症引起脑梗死的风险。方法:以我院收治的1例脑梗死患者为研究对象,对患者既往病史、生活习惯等进行分析,同时对患者进行常规体检、血常规检查、颅脑CT检查等,并根据检查结果对该病引起脑梗死风险进行探讨。结果:患者脑梗死前2年曾有一次红细胞明显增高,但未引起有关医务人员重视,这可能是造成这次脑梗死的主要诱因。结论:红细胞增多症是容易引发患者脑梗死的风险因素之一,因而在日常体检、检查中应关注体检对象的红细胞数量,对红细胞异常增多患者进行进一步检查,及时采取有效干预措施,以降低脑梗死发生率。%Objective: To study the disease of grow in quantity of red blood cells to cause the risk of cerebral infarction. Methods: In our hospital 1 case of cerebral infarction patients as the research object, analyze the patients' medical history, lifestyle and so on, at the same time, regular checks on patients,blood routine examination, craniocerebral CT examination, etc., and according to the results of the disease caused by cerebral infarction risk were discussed. Results: the patients with cerebral infarction before 2 years once red blood cells increased obviously, but as to the attention of the relevant medical staff, which may be caused by the main cause of cerebral infarction. Conclusion: Red blood cells increased disease is easy to cause one of risk factors for cerebral infarction patients, and thus in daily physical examination, examination should focus on physical objects, the number of red blood cells to further check with abnormal red blood cells were increased, promptly take effective intervention measures, in order to reduce the incidence of cerebral infarction.

  16. Neurological Study on Senile with Sllent Cerebral Infarction%老年无症状性脑梗塞的神经心理学研究

    Institute of Scientific and Technical Information of China (English)

    唐勇; 马洪胜; 张伟强; 张华芳

    2001-01-01

    目的:确定老年无症状性脑梗塞(SCI)对于记忆、空间构象、逻辑思维、情感等多方面的影响。方法:应用韦氏记忆量表(wMS)、老年抑郁量表(GDS)、视觉保持测验(VRT),对61名老年SCI患者的神经心理学改变进行了测量。结果:老年SCI组和对照组WMS测试结果记忆商(MQ)明显降低,其错误分明显提高,老年SCI组情绪抑郁人数也明显高于对照组。结论:老年SCI病人记忆能力、视觉空间能力、注意能力均明显下降,尤以短时记忆、视觉记忆为著。%Objective: To determine the effect of silent cerebral infarction of senile on their memory, space conformation, logical thinking and affection. Method: 61 senile patients with silent cerebral infarction were assessed by Wechsler Memory Scale (WMS), the Geriatric Depression Scale (GlDS) and Visual Retention Test (VRT) . Result: The memory quotation (MQ) was significantly lower in senile infarct patients than control group. The error mark was also higher in patient group. Patients with infarction had higher incidence of depression. Conclusion: Patients with silent cerebral infarction had poor performance in neuropsychological test, especially in short- term memory and visual memory.

  17. Clinical Prognosis of 62 Patients With Large Area Cerebral Infarction%幕上大面积脑梗死62例临床预后研究

    Institute of Scientific and Technical Information of China (English)

    兰亚军

    2016-01-01

    目的:探讨幕上大面积脑梗死的并发症和临床治疗方法、效果,以及预后情况。方法选取2010年1月~2016年3月在我院接受治疗的幕上大面积脑梗死患者62例作为研究对象,按照病灶所处血供范围分为3组:>MCA组、MCA组和ACA或PCA组。分别在患者入院第1天、第15天、第30天使用NIHSS、GOS来进行评定。结果62例幕上大面积脑梗塞患者中,27例出现并发症,其中肺部感染、中枢性高热、上消化道出血较为常见。临床CT分型结果提示MCA组和>MCA组的脑疝死亡病例较多。结论 CT分型是诊断幕上大面积脑梗死的重要手段,该方法操作简单,分辨与判断的准确率较高,CT分型的结果对幕上大面积脑梗死患者的临床治疗和预后具有重要意义。%Objective To investigate the complications and clinical treatment methods, results and prognosis of large area cerebral infarction. Methods Selected from January 2010 to March 2016 in our hospital for treatment of large area cerebral infarction 62 cases as the research object, according to the blood supply of the lesion were divided into 3 groups: > MCA group, MCA group and ACA or PCA group. In patients admitted to hospital for first days, fifteenth days, thirtieth days using GOS, NIHSS to assess.Results Among 62 cases of large area cerebral infarction, 27 cases had complications, including pulmonary infection, central high fever and upper gastrointestinal bleeding. Clinical CT results showed that MCA group and MCA group, more cases died of cerebral hernia.Conclusion CT typing is an important method for diagnosis of large area cerebral infarction. The method is simple, accurate and accurate, CT typing results have important signiifcance for the clinical treatment and prognosis of patients with large area cerebral infarction.

  18. Clinical value of detection on serum monocyte chemotactant protein-1 and vascular endothelial cadherin levels in patients with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Xia Zhou; Cheng Zhang

    2016-01-01

    Objective: To study the correlation of serum monocyte chemotactant protein-1 (MCP-1) and vascular endothelia cadherin (VE-cadherin) levels in patients with acute cerebral infarction, and nerve injury molecules, interleukins and matrix metalloproteinases. Methods: A total of 86 patients with acute cerebral infarction treated in our hospital from April 2012 to October 2015 were selected as the observation group and 50 healthy subjects in the same period treated in our hospital were selected as the control group. The serums were collected and the contents of MCP-1, VE-cadherin, heart-type fatty acid binding protein (H-FABP), S100 calcium binding protein B (S100B), neuron-specific enolase (NSE), interleukin-lb (IL-1b), IL-6, IL-17, IL-18, matrix metalloproteinase-2 (MMP2), MMP3 and MMP9 were measured. Results: The serum contents of MCP-1, VE-cadherin, H-FABP, S100B, NSE, IL-1b, IL-6, IL-17, IL-18, MMP2, MMP3 and MMP9 in observation group were significantly higher than those of control group. Carotid artery plaque formation and unstable plaque properties will increase the serum contents of MCP-1, VE-cadherin, H-FABP, S100B, NSE, IL-1b, IL-6, IL-17, IL-18, MMP2, MMP3 and MMP9 in patients with cerebral infarction. The serum levels of MCP-1, VE-cadherin and the contents of H-FABP, S100B, NSE, IL-1b, IL-6, IL-17, IL-18, MMP2, MMP3 and MMP9 were positively correlated. Conclusions: The serum levels of VE-cadherin and MCP-1 were significantly increased in patients with acute cerebral infarction. MCP-1 and VE-cadherin can increase the secretion of interleukins and matrix metalloproteinases, which can result in the carotid artery plaque formation, unstable plaque properties and the injury of nerve function.

  19. The international normalized ratio (INR as seen in a population of patients with atrial fibrillation and cerebral infarction undergoing long-term treatment with vitamin K antagonists

    Directory of Open Access Journals (Sweden)

    Szczepańska-Szerej Anna

    2015-12-01

    Full Text Available It is estimated that nearly 20% of all cerebral infarctions in the total population are the result of a complication of atrial fibrillation (AF. While oral anticoagulation with vitamin K antagonists (AVKs substantially reduces this risk, this requires regular monitoring of the international normalized ratio (INR in order to achieve therapeutic levels (2,0-3,0. The aim of this study was to evaluate a group at high risk of cerebral infarction, among patients with AF undergoing long-term treatment with VKAs, taking into account the significance of therapeutic INR values. The analysed group consisted of 90 acute ischaemic stroke patients with paroxysmal or chronic “non-valvular” AF, receiving treatment with VKAs. As a result of the study, therapeutic INR values (≥ 2 were seen in thirty-five of these individuals (38,8%, while 55 (61,2% showed non-therapeutic INR values. Moreover, there were no differences in demographics, vascular risk factors, biochemical and morphological blood parameters, mean CHA2DS2-VASc score and TOAST classification between either of the two groups. Furthermore, no additional factor that would increase their risk of cerebral infarction during the adequate treatment with VKAs was found. However, patients with non-therapeutic INR values had a statistically significantly higher frequency of concomitant moderate pathology of the bicuspid valve, p<0.05. Hence, a lack of proper control of INR can proved to be particularly dangerous for this subgroup of patients. Hence, this is a group with an elevated risk of cerebral infarction and therefore requires special oversight of VKA treatment or NOA treatment.

  20. Clinical value of detection on ser um monocyte chemotactant protein-1 and vascular endothelial cadher in levels in patients with acute cerebral infarction

    Directory of Open Access Journals (Sweden)

    Xia Zhou

    2016-11-01

    Full Text Available Objective: To study the correlation of serum monocyte chemotactant protein-1 (MCP-1 and vascular endothelia cadherin (VE-cadherin levels in patients with acute cerebral infarction, and nerve injury molecules, interleukins and matrix metalloproteinases. Methods: A total of 86 patients with acute cerebral infarction treated in our hospital from April 2012 to October 2015 were selected as the observation group and 50 healthy subjects in the same period treated in our hospital were selected as the control group. The serums were collected and the contents of MCP-1, VE-cadherin, heart-type fatty acid binding protein (H-FABP, S100 calcium binding protein B (S100B, neuron-specific enolase (NSE, interleukin-lb (IL-1b, IL-6, IL-17, IL-18, matrix metalloproteinase-2 (MMP2, MMP3 and MMP9 were measured. Results: The serum contents of MCP-1, VE-cadherin, H-FABP, S100B, NSE, IL-1b, IL- 6, IL-17, IL-18, MMP2, MMP3 and MMP9 in observation group were significantly higher than those of control group. Carotid artery plaque formation and unstable plaque properties will increase the serum contents of MCP-1, VE-cadherin, H-FABP, S100B, NSE, IL-1b, IL-6, IL-17, IL-18, MMP2, MMP3 and MMP9 in patients with cerebral infarction. The serum levels of MCP-1, VE-cadherin and the contents of H-FABP, S100B, NSE, IL-1b, IL-6, IL-17, IL-18, MMP2, MMP3 and MMP9 were positively correlated. Conclusions: The serum levels of VE-cadherin and MCP-1 were significantly increased in patients with acute cerebral infarction. MCP-1 and VE-cadherin can increase the secretion of interleukins and matrix metalloproteinases, which can result in the carotid artery plaque formation, unstable plaque properties and the injury of nerve function.

  1. Use of acupuncture to treat cerebral infarction in the last 10 years A Scopus-based literature analysis A Scopus-based literature analysis

    Institute of Scientific and Technical Information of China (English)

    Jiajun Chen; Min Yao; Yunhua Zhao; Xiya Jin; Yuanbing Li; Lihong Huang

    2012-01-01

    OBJECTIVE: To identify global research trends in the use of acupuncture to treat cerebral infarction.SELECTION CRITERIA: Inclusion criteria: peer-reviewed articles on the use of acupuncture to treat cerebral infarction indexed in Scopus and published between 2002 and 2011; types of publications were original research articles, reviews, meeting abstracts, proceedings papers, book chapters, editorial material, and news items. Exclusion criteria: articles that required manual searching or telephone access; documents that were not published in the public domain; and corrected papers.MAIN OUTCOME MEASURES: (a) Annual publication output; (b) language of publication; (c) type of publication; (d) key words of publication; (e) publication by research field; (f) publication by journal; (g) publication by country and institution; (h) publication by author; (i) most-cited papers between 2002 and 2006; and (j) most-cited papers between 2007 and 2011.CONCLUSION: In the field of neuroscience, there is little literature on acupuncture for cerebral infarction. The most-cited papers were cited 30 times in the past 3 years. We believe that, with advances in the study of mechanisms in neurobiology, research on acupuncture will also advance and will become the concern of more scholars.

  2. 老年糖尿病脑梗塞患者的护理体会%Nursing Experience of Elder Diabetic Patients with Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    范妍

    2014-01-01

    目的对老年糖尿病合并脑梗塞的护理效果。方法55例老年糖尿病合并脑梗死患者在我院的个案,以临床护理学,临床分析。结果临床护理和治疗,治愈31例(56.4%),有效17例(30.9%),无效7例(12.7%),总有效率达87.3%。结论治疗原发性老年糖尿病合并脑梗塞,给出科学合理的护理可有效提高治疗效果。%Objective The nursing ef ect on senile diabetes complicated with cerebral infarction. Methods 55 patients with senile diabetes complicated with cerebral infarction in our hospital were selected cases, take the clinical nursing science, comprehensive, clinical analysis. Results The clinical nursing treatment and system, 31 cases were cured (56.4%), ef ective in 17 cases (30.9%), invalid 7 cases (12.7%), the total ef ective rate was 87.3%. Conclusion For the patients with primary senile diabetes complicated with cerebral infarction, give a scientific and reasonable nursing can ef ectively improve the therapeutic ef ect.

  3. Relativity analysis of arterosclerotic cerebral infarction of senile patients and secondary epilepsy%老年动脉硬化性脑梗死与继发性癫痫相关性分析

    Institute of Scientific and Technical Information of China (English)

    张英杰; 马艳

    2001-01-01

    @@Background: Acute cerebral vascular secondary epilepsy isn't uncommon in clinic.It can happen at any time of epilepsy,even as first- onset or main clinical manifestation.Main cause of stroke of senile patients is arteriosclerosis,which is main cause of old stage epilepsy. Objective:To analyze relativity of arterosclerotic cerebral infarction of senile patients and secondary epilepsy.

  4. Effect of fasudil combined with conventional therapy on nerve and blood coagulation function as well as Hcy metabolism in patients with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Zhi-Yong Lu

    2017-01-01

    Objective:To analyze the effect of fasudil combined with conventional therapy on nerve and blood coagulation function as well as Hcy metabolism in patients with acute cerebral infarction. Methods:80 patients with acute cerebral infarction treated in our hospital between January 2013 and January 2013 were selected as the research subjects and divided into observation group (n = 40) and control group (n = 40) according to the random number table. Control group received conventional therapy and observation group received fasudil combined with conventional therapy. After 14 d of treatment, the levels of cerebral blood perfusion parameters, nerve function indexes, platelet function indexes and homocysteine (Hcy) of two groups of patients were determined.Results:After 14 d of treatment, middle cerebral artery and basilar artery peak systolic flow velocity (Vs), low diastolic flow velocity (Vd) and mean flow velocity (Vm) levels of observation group were higher than those of control group (P<0.05); serum nerve function indexes brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) content were higher than those of control group (P<0.05) while phosphatidic acid (PA), neuron-specific enolase (NSE), S100β protein (S100β), and substantia nigra divalent metal transporter 1 (DMT1) content were lower than those of control group (P<0.05); serum platelet function indexes platelet activation-dependent granule membrane protein-140 (GMP-140), fibrinogen receptor-1 (PAC-1), platelet activating factor (PAF) and platelet-derived growth factor BB (PDGF-BB) content were lower than those of control group (P<0.05); serum Hcy content was lower than that of control group (P<0.05).Conclusions:Fasudil combined with conventional therapy can optimize the nerve function and blood coagulation function in patients with acute cerebral infarction, and also plays a positive role in reducing Hcy levels.

  5. The active metabolite of prasugrel, R-138727, improves cerebral blood flow and reduces cerebral infarction and neurologic deficits in a non-human primate model of acute ischaemic stroke.

    Science.gov (United States)

    Sugidachi, Atsuhiro; Mizuno, Makoto; Ohno, Kousaku; Jakubowski, Joseph A; Tomizawa, Atsuyuki

    2016-10-05

    Previously, we showed preventive effects of prasugrel, a P2Y12 antagonist, in a non-human primate model of thrombotic middle cerebral artery occlusion (MCAO); however, it remains unclear if P2Y12 inhibition after MCAO reduces cerebral injury and dysfunction. Here we investigated the effects of R-138727, the major active metabolite of prasugrel, on ex vivo platelet aggregation at 5min, 15min, 60min, and 24h after administration to non-human primates (n=3). A single intravenous dose of R-138727 (0.03-0.3mg/kg) resulted in significant and sustained dose-related effects on platelets for up to 24h. R-138727 was administered 1h after MCAO induction, and its effects on thrombosis, cerebral infarction, and neurological deficits were determined (n=8-10). R-138727 (0.3mg/kg) significantly increased total patency rate of the MCA (P=0.0211). Although there was no effect on the patency rate before R-138727 dosing (P=0.3975), it increased 1h after dosing (P=0.0114). R-138727 significantly reduced total ischaemic infarction volumes (P=0.0147), including those of basal ganglia (P=0.0028), white matter (P=0.0393), and haemorrhagic infarction (P=0.0235). Additionally, treatment with R-138727 reduced overall neurological deficits (P=0.0019), including the subcategories of consciousness (P=0.0042), sensory system (P=0.0045), motor system (P=0.0079) and musculoskeletal coordination (P=0.0082). These findings support the possible utility of P2Y12 inhibition during early-onset MCAO to limit the progression and degree of cerebral ischaemia and infarction and also associated neurological deficits.

  6. [Cerebral artery infarction presented as an unusual complication of acute middle otitis].

    Science.gov (United States)

    Moscote-Salazar, Luis Rafael; Alcalá-Cerra, Gabriel; Castellar-Leones, Sandra Milena; Gutiérrez-Paternina, Juan José

    2013-01-01

    Introducción: la otitis media aguda es una inflamación del oído medio frecuente en la edad pediátrica. Aproximadamente 2 % de todos los casos desarrolla complicaciones intracraneales, más específicamente meningitis; por lo general, los infartos cerebrales originados por esta última son venosos. Rara vez se ha descrito la ocurrencia de un infarto arterial cerebral como complicación directa de la otitis media aguda. Caso clínico: niña de 12 meses de edad quien fue llevada a un servicio de urgencias por síndrome febril secundario a otitis media aguda y alteración del estado de conciencia. A la exploración física se identificó que estaba somnolienta, con anisocoria, midriasis en el ojo derecho y hemiparesia izquierda. Con la tomografía axial computarizada de cerebro se apreció un infarto arterial cerebral extenso. Los padres no autorizaron la craniectomía descompresiva y la paciente falleció a las 48 horas de su ingreso hospitalario. Conclusiones: a pesar de los recursos tecnológicos con los que se dispone actualmente, el infarto cerebral relacionado con la otitis media aguda tiene una evolución tórpida. Los signos neurológicos focalizadores y el deterioro progresivo deben apuntar a la ineficacia del tratamiento antimicrobiano instaurado.

  7. 血压与出血性脑梗死预后的关系探讨%Relationships between blood pressure and hemorrhagic cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    邱金华; 刘红英; 蔡春生

    2011-01-01

    Objective To explore the relationship between blood pressure and hemorrhagic cerebral infarction. Methods Retrospectively reviewed clinical data of 242 patients with acute cerebral infarction, then all patients with hemorrhagic cerebral infarction were selected. The distributions of different level of blood pressure (>180/110mm Hg;90/70~180/110mm Hg;<90/70mm Hg) were compared between the patients with or without hemorrhagic cerebral infarction, as the same, different prognosis were compared among the patients with hemorrhagic cerebral infarction based on the different level of blood pressure. Results Of the total patients with acute cerebral infarction,4. 1%(10) presented with blood pressure<90/70mm Hg,88. 0%(213) with blood pressure 90/70~180/110mm Hg and 7.9%(19) with blood pressure>180/110mm Hg. In all the patients,20 cases(8. 3%) with hemorrhagic cerebral infarction,among which,60.0%(12) patients with blood pressure>180/110mm Hg and with 7 cases died, 10.0%(2) patients with blood pressure<90/70mm Hg and with 1 case died,30.0%(6) patients with blood pressure 90/70~180/110mm Hg and with 2 cases died. The distribution of patients with blood pressure>180/110mm Hg in those two type of cerebral infraction were statistically significant (P=0. 000) ,the ratio seemed higher in patients with hemorrhagic cerebral infarction, and among the patients with hemorrhagic cerebral infarction, the distribution of prognosis were the same statistically significant based on the diffetent level of blood pressure, among which, patients with blood pressure>180/110mm Hg(P =0.041) or<90/70mm Hg(P =0.037) seemed like to have a higher mortality. Conclusion Severe high blood pressure(>180/110mm Hg) should be one of the high risk factors for patients with hemorrhagic cerebral infarction,when blood pressure>180/110 mm Hg or <90/70mm Hg happened in the pathogenesis, patients always be with poor outcome. So, making proper control strategy of blood pressure for

  8. Effects of acupuncture therapy on plasma neuropeptide Y levels and resuscitation in patients with very early stage acute cerebral infarction A randomized controlled study

    Institute of Scientific and Technical Information of China (English)

    Guozhong Zhang; Lina Ning; Sujuan Gao

    2009-01-01

    BACKGROUND: It is known that acupuncture therapy can decrease plasma neuropeptide Y (NPY) levels in patients with cerebral infarction, but different types of acupuncture therapy used in various stages of cerebral infarction have not been evaluated.OBJECTIVE: To explore the effect of acupuncture therapy on resuscitation (Xingnao Kaicliao) and plasma NPY levels in patients with very early stage acute cerebral infarction.DESIGN, TIME AND SETTING: This case-controlled study was performed at the Affiliated Hospital of the Medical College of the Chinese People's Armed Police Force between September 2004 and October 2005.PARTICIPANTS: Sixty patients with acute cerebral infarction of ≤ 6 hours were used in this study. Patients were randomly divided into an acupuncture therapy group (n = 30) and a routine treatment group (n = 30). Another 30 healthy subjects were used as the control group.METHODS: The acupuncture therapy of Xingnao Kaiqiao used in the acupuncture therapy group was based on routine western medical treatment and was performed at bilateral Neiguan (PC6) using the twirling, reinforcing-reducing method, Renzhong (DU26) using heavy bird-pecking needling, Sanyinjiao (SP6) using reinforcing and reducing by lifting and thrusting the needle, Jiquan (HT1), Weizhong (BL40) and Chize (LU5) using reinforcing and reducing by lifting and thrusting the needle. The acupuncture lasted for 14 days. Patients in the routine treatment group underwent routine medical treatment and no intervention was given to subjects in the control group.MAIN OUTCOME MEASURES: A 4 mL venous blood sample was obtained at different time points, I.e., immediately after hospitalization, the next morning, 7 and 14 days after treatment, to measure plasma NPY levels pre- and post-treatment using the radio-immunity method.RESULTS: The plasma NPY levels were significantly higher in both the routine treatment group and the acupuncture therapy group than in the control group pre- and post-treatment (P < 0

  9. Clinical analysis of 128 cases of cerebral infarction in young patients%青年脑梗死128例临床分析

    Institute of Scientific and Technical Information of China (English)

    韩传孝; 王修军; 李凤玲

    2011-01-01

    目的 探讨青年脑梗死的病因、危险因素、临床特点及预后.方法 回顾性分析128例青年脑梗死患者的临床资料.结果 115例有明确病因(89.84%),13例病因不详(10.12%).主要危险因素有:高血压病、吸烟、家族史、短暂性脑缺血发作及高血脂症.临床特点为:多见于男性,意识障碍少,预后较好.结论 青年脑梗死的病因以动脉粥样硬化最多见,其次为炎症性血管病和心源性栓塞,主要危险因素是高血压病、吸烟、家族史、短暂性脑缺血发作及高血脂症.一般预后较好,治愈率高,病死率低.%Objective To investigate the cause, dangerous factors,clinical features and prognosis of cerebral infarction in young patients. Methods To review the clinical data of 128 patients with cerebral infarction. Results There were 115 patients who had clear causes(89. 84% ) , and 13 patients who had no clear cause ( 10. 12% ). The main dangerous factors of cerebral infarction in young patients includes hypertension, smoking, family history, TIA and hyperlipemia. The features of cerebral infarction in young patients includes more male patients, and less disturbance of consciousness. The prognosis of the patients was good. Conclusions The main cause of cerebral infarction in young patients is arteriosclerosis.The minor causes are inflammation of vessels and embolism from heart. The main dangerous factors includes hypertension, smoking, family history, TIA and hyperlipemia. The prognosis of the patients is good. The recovery rate is high and the mortality is low.

  10. Polysomnographic evaluation of the patients at recovery stage of cerebral infarction%脑梗死恢复期患者的多道睡眠图评价

    Institute of Scientific and Technical Information of China (English)

    李冲; 宋景贵; 杜好瑞; 谭春英; 张帆; 张宁

    2001-01-01

    目的 探讨脑梗死恢复期患者睡眠参数改变的生物学特点。方法 应用多道睡眠图对35例脑梗死恢复期患者进行睡眠描记,分析相关睡眠参数,并与20例正常人比较。结果 脑梗死恢复期患者睡眠潜伏期延长(38.44 min)、总睡眠时间减少(259.71 min)、中途醒转次数增多(7.55次)、睡眠效率低(58.06%)、快眼动(REM)睡眠潜伏期缩短(62.36 min)、REM睡眠时间(32.42 min)和REM活动度(67.91单位)减少(P<0.05~0.01)。结论 脑梗死恢复期患者不但有睡眠量的减少,而且伴有睡眠质的改变,其中REM睡眠潜伏期、REM睡眠时间和REM活动度是评价脑功能恢复的客观指标。%Objectives To study the biological characteristics of sleep parameter changes for the patients at recovery stage of cerebral infarction. Methods The sleep was recorded of 35 patients at recovery stage of cerebral infarction by polysomnography,and relevant sleep parameters were analysed, and then compared with 20 normal controls. Results The prolonged sleep latency(38.44 min),decreased total sleep time(259.71 min),increased frequency of awakenings or arousals during sleep(7.55 times),lowered sleep efficiency (58.06%), shortened rapid eye movement(REM) sleep latency(62.36 min),decreased REM sleep time(32.42 min) and REM activity(67.91 unit)were shown in the patients at recovery stage of cerebral infarction (P<0.05-0.01). Conlusions It is suggested that not only sleep decreased in quantity,but also accompanied with changes in quality for the patients at recovery stage of cerebral infarction.REM sleep latency, REM sleep time and REM activity are objective indexes to estimate the recovery for cerebral infarction.

  11. Embryologic Association of Tornwaldt's Cyst with Cerebral Artery Abnormalities and Infarction: A Case Report

    Directory of Open Access Journals (Sweden)

    Michael F. Osborn

    2012-01-01

    Full Text Available Background and Purpose. Tornwaldt's cysts are rare nasopharyngeal lesions that develop from remnants of the embryonic notochord. Summary of Case. We reported a twelve-year-old female stroke patient with Tornwaldt's cysts, whose father also suffered a stroke at age fifty two with the presence of an abdominal aortic aneurysm, suggesting a genetic influence in this case. Conclusions. This paper suggests an etiologic connection between Tornwaldt's cysts and cerebral vasculature abnormalities by way of notochordal dysfunction during development, likely the result of perturbation of notochord-derived molecular cues during development or biogenesis.

  12. Clinical analysis of sleep disorders in patients with acute cerebral infarction%急性脑梗死患者睡眠障碍的临床分析

    Institute of Scientific and Technical Information of China (English)

    陈美琳; 陈娟; 王晓利

    2015-01-01

    目的:探讨急性脑梗死患者睡眠障碍的临床特点。方法对72例脑梗死患者,根据病史并采用匹兹堡睡眠指数问卷(PSQI),神经功能缺损程度评分(NDS),及多导睡眠图(PSG)进行研究。结果急性脑梗死患者睡眠障碍的临床表现形式主要以失眠为主,检出率为44.4%,女性大于男性。脑梗死神经缺损越严重,睡眠障碍的发生率就越高。脑梗死患者皮质下梗死较皮质梗死、小脑梗死睡眠障碍的发生率高。急性脑梗死睡眠障碍的患者PSG改变为:总睡眠时间减少,入睡潜伏期延长,睡眠效率明显降低。NREMⅠ期睡眠明显增多,Ⅱ期和Ⅲ期睡眠减少。结论急性脑梗死睡眠障碍的发生率较高,发病与多种因素有关,通过了解脑梗死睡眠障碍患者的睡眠情况有助于指导治疗。%Objective To explore the characteristics of sleep disorders in patients with acute cere‐bral infarction .Methods Adopting medical history and Pittsburgh Sleep QuestionnaireIndex(PSQI) ,de‐gree of Nerve Function Defect Score (NDS)and Polysomnography (PSG) methods to study 72 patients with cerebral infarction .Results Clinical manifestation of sleep disorders in patients with acute cerebral infarction was mainly suffering from insomnia ,the detection rate was 44 .4% ,and the rate of women washigher than men .The more serious Cerebral infarction nerve defect ,the higher the incidence rate of sleep disorders .Patients with subcortical infarction were more likely to have sleep prbolems .PSG chan‐ges for patients with acute cerebral infarction of sleep disorders:total sleep time reduced ,sleep latency extended ,sleep efficiency decreased .NREM sleepⅠstage significantly increased and stage Ⅱand Ⅲ de‐creased .Conclusions The sleep disorder incidence rate of patients with acute cerebral infarction is high‐er ,which is associated with a variety of factors ,by understandingthe sleep state of

  13. [MYCOTIC ANEURYSM OF THE ASCENDING AORTA AND CEREBRAL INFARCTS IN A 17-MONTH OLD CHILD WITH KINGELLA KINGAE ENDOCARDITIS].

    Science.gov (United States)

    Feldman, Liat Feraru; Hersh, Ziv; Birk, Einat; Amir, Gabi; Wertheimer, George

    2015-06-01

    Endocarditis is an uncommon presentation of Kingella kingae infection in children. A previously healthy 17 month old child was referred to our emergency department for evaluation of fever lasting eleven days, aphthous stomatitis and a new systolic murmur. Within a few hours of admission, antibiotic therapy was initiated for a presumptive diagnosis of bacteremia and within 24 hours after admission, gram negative coccobacilli were growing in the blood culture. In addition, echocardiography demonstrated a mycotic aneurysm of the ascending aorta with a mobile vegetation. The presumptive diagnosis of Kingella kingae endocarditis was made. Further evaluation by MRI revealed frontal and occipital cerebral infarcts. Due to the presence of presumed septic emboli in conjunction with progressive left ventricular dysfunction, the child was urgently taken to the operating room where aggressive debridement of the infected tissue was performed and the aortic aneurysm was repaired. The patient had an uneventful post-operative course. This case emphasizes the need for a high index of suspicion when evaluating children with community acquired infection. In addition, it also demonstrates the importance of early diagnosis and appropriate treatment of K. kingae endocarditis.

  14. The study of ministellite region polymorphisms at 3' end of apollpoprotein B gene in atherosclerotic cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Zhang Yong; Qin Zen

    2000-01-01

    Objective Atheroselerotic cerebral infarction ACI) as agradually progresive atherosclerotic disorder has been thought be a hetero-ground and multictor of environment There are in different epidemiologic state. The relationship of ministellite region polymorphisms at 3′-end of apolipoprotein B gene in Chinese ACI and normal healthy controls were observed. Method The 3′ hyprevariabieministellite polymorphism of apolipoprotein B gene were examined by polymerase chain reaction technique in 84 patients with ACI and 107 age-matched Chinese bealthy controls.The targeted ministellite region were amplified rapidly and accurately, and than identified. Results The frequency distribution of apolipoprotion B 3'ministellite region alleles were in monomold peaks at 37,39 repeat uints in both group,and the big number repeat units(MSRB) is higher in ACI than normal controls.The homozygote genotype of the big number repeat units alleles had a relationship to the high level of apolipoprotein and LDL.There were same tandency in ACI and controls. Conclusion The possibility that there apolipoprotein B 3′ gene ministellite region alleles polymorphism increase the susceptibility to atheroscierosis by means other than by altering lipoprotein levels deserves further consideration

  15. [Risk of death 4 years after a 1st cerebral infarction: prospective study in Barquisimeto, Estado Lara, Venezuela].

    Science.gov (United States)

    Poni, E; Granero, R; Escobar, B

    1995-12-01

    Stroke, the 5th. cause of death in Venezuela, has been associated to cerebral infarction. However, there is little information concerning lethality factors. 33 atherothrombotic subtype stroke patients, 31 (96%) Latino and 2(4%) white, were admitted into a prospective study to analyze the role of 11 mortality risk factors for those patients. A mortality relative risk (RR) > 1.5 or < 1 (protective) was considered clinically important if 1 was excluded from the 95% confidence interval (95%CI). The Mantel-Haenszel Chi-square procedure was use to test statistical significance (p < 0.05). Mortality RR for patients age 65 and over (RR = 2.95) and 4 year mortality RR for male patients (RR = 2.04) were clinically and statistically significant. History of high blood pressure was protective (RR = 0.62) probably due to good medical control. Cumulative mortality was higher than that of comparable studies, even from the first week of follow-up, reaching 67% at the 4th year.

  16. An unusual case of cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy with occipital lobe involvement

    Directory of Open Access Journals (Sweden)

    Bhavesh Trikamji

    2016-01-01

    Full Text Available Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL is an autosomal dominant angiopathy caused by a mutation in the notch 3 gene on chromosome 19. Clinically, patients may be asymptomatic or can present with recurrent ischemic episodes and strokes leading to dementia, depression, pseudobulbar palsy, and hemi- or quadraplegia. Additional manifestations that have been described include migraine (mostly with aura, psychiatric disturbances, and epileptic seizures. Neuroimaging is essential to the diagnosis of CADASIL. On imaging CADASIL is characterized by symmetric involvement by confluent lesions located subcortically in the frontal and temporal lobes as well as in the insula, periventricularly, in the centrum semiovale, in the internal and external capsule, basal ganglia, and brain stem; with relative sparing of the fronto-orbital and the occipital subcortical regions. We describe a 49 year old male with CADASIL with absence of temporal lobe findings on MRI but predominant lesions within the periventricular white matter, occipital lobes with extension into the subcortical frontal lobes, corpus callosum and cerebellar white matter. Although CADASIL characteristically presents with anterior temporal lobe involvement, these findings may be absent and our case addresses the atypical imaging findings in CADASIL.

  17. [Simultanagnosia and scene agnosia induced by right posterior cerebral artery infarction: a case report].

    Science.gov (United States)

    Kobayashi, Yasutaka; Muramatsu, Tomoko; Sato, Mamiko; Hayashi, Hiromi; Miura, Toyoaki

    2015-01-01

    A 68-year-old man was admitted to our hospital for rehabilitation of topographical disorientation. Brain magnetic resonance imaging revealed infarction in the right medial side of the occipital lobe. On neuropsychological testing, he scored low for the visual information-processing task; however, his overall cognitive function was retained. He could identify parts of the picture while describing the context picture of the Visual Perception Test for Agnosia but could not explain the contents of the entire picture, representing so-called simultanagnosia. Further, he could morphologically perceive both familiar and new scenes, but could not identify them, representing so-called scene agnosia. We report this case because simultanagnosia associated with a right occipital lobe lesion is rare.

  18. Structural changes in pyramidal cell dendrites and synapses in the unaffected side of the sensorimotor cortex following transcranial magnetic stimulation and rehabilitation training in a rat model of focal cerebral infarct

    Institute of Scientific and Technical Information of China (English)

    Chuanyu Liu; Surong Zhou; Xuwen Sun; Zhuli Liu; Hongliang Wu; Yuanwu Mei

    2011-01-01

    Very little is known about the effects of transcranial magnetic stimulation and rehabilitation training on pyramidal cell dendrites and synapses of the contralateral, unaffected sensorimotor cortex in a rat model of focal cerebral infarct. The present study was designed to explore the mechanisms underlying improved motor function via transcranial magnetic stimulation and rehabilitation training following cerebral infarction. Results showed that rehabilitation training or transcranial magnetic stimulation alone reduced neurological impairment in rats following cerebral infarction, as well as significantly increased synaptic curvatures and post-synaptic density in the non-injured cerebral hemisphere sensorimotor cortex and narrowed the synapse cleft width. In addition, the percentage of perforated synapses increased. The combination of transcranial magnetic stimulation and rehabilitation resulted in significantly increased total dendritic length, dendritic branching points, and dendritic density in layer V pyramidal cells of the non-injured cerebral hemisphere motor cortex.These results demonstrated that transcranial magnetic stimulation and rehabilitation training altered structural parameters of pyramidal cell dendrites and synapses in the non-injured cerebral hemisphere sensorimotor cortex, thereby improving the ability to compensate for neurological functions in rats following cerebral infarction.

  19. Recombinant Tissue Plasminogen Activator Induces Neurological Side Effects Independent on Thrombolysis in Mechanical Animal Models of Focal Cerebral Infarction: A Systematic Review and Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Mei-Xue Dong

    Full Text Available Recombinant tissue plasminogen activator (rtPA is the only effective drug approved by US FDA to treat ischemic stroke, and it contains pleiotropic effects besides thrombolysis. We performed a meta-analysis to clarify effect of tissue plasminogen activator (tPA on cerebral infarction besides its thrombolysis property in mechanical animal stroke.Relevant studies were identified by two reviewers after searching online databases, including Pubmed, Embase, and ScienceDirect, from 1979 to 2016. We identified 6, 65, 17, 12, 16, 12 and 13 comparisons reporting effect of endogenous tPA on infarction volume and effects of rtPA on infarction volume, blood-brain barrier, brain edema, intracerebral hemorrhage, neurological function and mortality rate in all 47 included studies. Standardized mean differences for continuous measures and risk ratio for dichotomous measures were calculated to assess the effects of endogenous tPA and rtPA on cerebral infarction in animals. The quality of included studies was assessed using the Stroke Therapy Academic Industry Roundtable score. Subgroup analysis, meta-regression and sensitivity analysis were performed to explore sources of heterogeneity. Funnel plot, Trim and Fill method and Egger's test were obtained to detect publication bias.We found that both endogenous tPA and rtPA had not enlarged infarction volume, or deteriorated neurological function. However, rtPA would disrupt blood-brain barrier, aggravate brain edema, induce intracerebral hemorrhage and increase mortality rate.This meta-analysis reveals rtPA can lead to neurological side effects besides thrombolysis in mechanical animal stroke, which may account for clinical exacerbation for stroke patients that do not achieve vascular recanalization with rtPA.

  20. Recombinant Tissue Plasminogen Activator Induces Neurological Side Effects Independent on Thrombolysis in Mechanical Animal Models of Focal Cerebral Infarction: A Systematic Review and Meta-Analysis

    Science.gov (United States)

    Wei, You-Dong; Liu, Yi-Yun; Ren, Yi-Fei; Liang, Zi-Hong; Wang, Hai-Yang; Zhao, Li-Bo; Xie, Peng

    2016-01-01

    Background and Purpose Recombinant tissue plasminogen activator (rtPA) is the only effective drug approved by US FDA to treat ischemic stroke, and it contains pleiotropic effects besides thrombolysis. We performed a meta-analysis to clarify effect of tissue plasminogen activator (tPA) on cerebral infarction besides its thrombolysis property in mechanical animal stroke. Methods Relevant studies were identified by two reviewers after searching online databases, including Pubmed, Embase, and ScienceDirect, from 1979 to 2016. We identified 6, 65, 17, 12, 16, 12 and 13 comparisons reporting effect of endogenous tPA on infarction volume and effects of rtPA on infarction volume, blood-brain barrier, brain edema, intracerebral hemorrhage, neurological function and mortality rate in all 47 included studies. Standardized mean differences for continuous measures and risk ratio for dichotomous measures were calculated to assess the effects of endogenous tPA and rtPA on cerebral infarction in animals. The quality of included studies was assessed using the Stroke Therapy Academic Industry Roundtable score. Subgroup analysis, meta-regression and sensitivity analysis were performed to explore sources of heterogeneity. Funnel plot, Trim and Fill method and Egger’s test were obtained to detect publication bias. Results We found that both endogenous tPA and rtPA had not enlarged infarction volume, or deteriorated neurological function. However, rtPA would disrupt blood-brain barrier, aggravate brain edema, induce intracerebral hemorrhage and increase mortality rate. Conclusions This meta-analysis reveals rtPA can lead to neurological side effects besides thrombolysis in mechanical animal stroke, which may account for clinical exacerbation for stroke patients that do not achieve vascular recanalization with rtPA. PMID:27387385

  1. Etioloy and potential mechanism of cerebral infarction post severe traumatic brain injury%重型颅脑损伤并发脑梗死的成因及机制探讨

    Institute of Scientific and Technical Information of China (English)

    刘胜文; 王胜; 刘星; 万学焱; 张所军; 徐钰; 杨洪宽; 舒凯; 雷霆

    2014-01-01

    目的 探讨重型颅脑损伤后脑梗死的临床特点、高危因素及发病机制.方法 分析2012年至2013年武汉同济医院神经外科收治的发生脑梗死(24例)与未梗死(46例)的重型颅脑损伤患者的临床资料,比较两组患者的临床特征.结果 经治疗后梗死组的好转率(58%)明显低于非梗死组(83%);梗死组患者入院24 h内的最高体温为(38.1±0.8)℃,凝血功能异常发生率(75%)明显高于非梗死组(26%)(P<0.05);梗死组大脑中动脉痉挛发生率(75%)高于非梗死组(35%)(P<0.05).结论 脑梗死严重影响重型颅脑损伤患者的预后,脑血管痉挛、血管结构的损害和压迫是重型颅脑损伤后脑梗死的高危因素.%Objective To investigate the clinical characteristics,risk factors and potential mechanism of cerebral infarction post severe traumatic brain injury(TBI).Method Clinical records of 24 patients suffering cerebral infarction and 46 patients without cerebral infarction after severe TBI were reviewed retrospectively.Results patients with cerebral infarction got a survival rate at 58%,lower than patients without cerebral infarction (83%).The maximal body temperature (38.1 ± 0.8) ℃ in the first 24hrs,incidence of coagulating dysfunction (75%) and middle cerebral artery spasm(75%) were much higher in infarction group than the non-infarction group (P < 0.05).Conclusion Cerebral infarction exerts a tremendous influence on the prognosis of severe TBI.Cerebral vessel spasm,devastation and compression of the vessel structure are the high risk factors for cerebral infarction after severe TBI.

  2. The youth cerebral infarction clinical to explore the clinical characteristics and incidence of younger reasons%青年脑梗死临床特点及发病原因分析

    Institute of Scientific and Technical Information of China (English)

    黄益洪; 陈建军; 方浩威; 梅志忠; 黄晓芸

    2013-01-01

      目的分析青年脑梗死临床特点及发病年轻化原因,以指导临床防治,减少发病率和病残率。方法应用“生物-心理-社会”的医学模式,对25例青年脑梗死患者和25例中老年脑梗塞患者病因进行对比分析,研究青年脑梗死患者的发病原因。结果青年脑梗死的发病原因主要有早发性动脉粥样硬化、高血脂、糖尿病、高血压等,此外,睡眠质量差、工作压力大、生活节奏快,加之熬夜、喝酒、吸烟等不良习惯诱导,是引发脑梗死年轻化的综合原因。结论为了预防青年脑梗死的发生,应对工作生活压力进行合理释放,对心理因素进行调节,摒弃不良嗜好,注意健康饮食,从而实现青年脑梗死发病率逐渐降低的目标。%  Objective The incidence of cerebrovascular disease in recent years the rise year by year, especially in young patients with cerebral infarction. To explore the clinical characteristics and incidence of the youth cerebral infarction. Methods Application of biological-psychological-social medical model, 25 cases of young patients with cerebral infarction and 25 patients with senile cerebral infarction etiology were analyzed, to explore the causes of youth cerebral infarction patients. Results The youth cerebral infarction are main causes early-onset atherosclerosis, hyperlipidemia, diabetes, high blood pressure, etc., in addition, the poor quality of sleep, work pressure, life rhythm is fast, and stay up late, bad habits such as drinking, smoking, induction, is a comprehensive causes of cerebral infarction younger. Conclusion In order to prevent the happening of the youth cerebral infarction, deal with work stress properly released, adjusted to the psychological factors, abandon the bad habits, pay attention to healthy eating, so as to realize the goal of youth cerebral infarction incidence reduced gradually.

  3. Assessment of arcuate fasciculus with diffusion-tensor tractography may predict the prognosis of aphasia in patients with left middle cerebral artery infarcts

    Energy Technology Data Exchange (ETDEWEB)

    Hosomi, Akiko; Nagakane, Yoshinari; Kuriyama, Nagato; Mizuno, Toshiki; Nakagawa, Masanori [Kyoto Prefectural University of Medicine, Department of Neurology, Graduate School of Medical Science, Kyoto (Japan); Yamada, Kei; Nishimura, Tsunehiko [Kyoto Prefectural University of Medicine, Department of Radiology, Graduate School of Medical Science, Kyoto (Japan)

    2009-09-15

    It is often clinically difficult to assess the severity of aphasia in the earliest stage of cerebral infarction. A method enabling objective assessment of verbal function is needed for this purpose. We examined whether diffusion tensor (DT) tractography is of clinical value in assessing aphasia. Thirteen right-handed patients with left middle cerebral artery infarcts who were scanned within 2 days after stroke onset were enrolled in this study. Magnetic resonance data of ten control subjects were also examined by DT tractography. Based on the severity of aphasia at discharge, patients were divided into two groups: six patients in the aphasic group and seven in the nonaphasic group. Fractional anisotropy (FA) and number of arcuate fasciculus fibers were evaluated. Asymmetry index was calculated for both FA and number of fibers. FA values for the arcuate fasciculus fibers did not differ between hemispheres in either the patient groups or the controls. Number of arcuate fasciculus fibers exhibited a significant leftward asymmetry in the controls and the nonaphasic group but not in the aphasic group. Asymmetry index of number of fibers was significantly lower (rightward) in the aphasic group than in the nonaphasic (P = 0.015) and control (P = 0.005) groups. Loss of leftward asymmetry in number of AF fibers predicted aphasia at discharge with a sensitivity of 0.83 and specificity of 0.86. Asymmetry of arcuate fasciculus fibers by DT tractography may deserve to be assessed in acute infarction for predicting the fate of vascular aphasia. (orig.)

  4. Comparison of the level of thrombus precursor protein in blood plasma between patients with acute cerebral infarction and healthy persons at different time

    Institute of Scientific and Technical Information of China (English)

    Chenghua Xiao; Peng Zhang

    2006-01-01

    BACKGROUND: Thrombus precursor protein (TpP) is the index of thrombus activity level, and it is also early referencing index in detecting thrombus diseases.OBJECTIVE: To dynamically observe the changes of TpP level in blood plasma of patients with acute cerebral infarction at different time after onset, and to compare the differences of plasma TpP level between patients with acute cerebral infarction and healthy persons who received health examination.DESIGN: Controlled observation.SETTING: Department of Neurology, Affiliated Hospital of Xuzhou Medical College.PARTICIPANTS: Totally 58 patients with acute cerebral infarction who received the treatment in the Department of Neurology, Affiliated Hospital of Xuzhou Medical College between September 2004 and March 2005 were recruited in this study. They all met the diagnostic criteria revised by the 4th National Conference of Cerebrovascular Disorders in 1995 and were diagnosed by clinical and skull CT and (or) MRI examinations. The patients included 33 male and 25 female aged from 36 to 87 years. Time to onset < 6 hours, 6 to 11 hours, 12 to 23 hours, 24 to 48 hours and > 48 hours were found in 10,11,14,10 and 13 patients respectively. Another 51 persons who homeochronously received the health body examination in our hospital were recruited, including 34 male and 17 female, aged 38 to 85 years, serving as control group. Patients with cardio-cerebrovascualr diseases or liver and kidney diseases were excluded. All the involved subjects were informed of the detected items.METHODS: About 4 mL venous blood was respectively taken from patients admitted to the hospital within 6 hours, 6 to11 hours, 12 to 23 hours, 24 to 48 hours and more then 48 hours after onset, and healthy persons when receiving health examination. The level of TpP in blood plasma was measured with enzymelinked immunosorbent assay.MAIN OUTCOME MEASURES: ① Comparison of the level of plasma TpP between patients and controls; ② Comparison of the level

  5. Effect of extracranial electric stimulation at cerebellar fastigial nucleus on serum C-reactive protein of patients with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: Some reports indicate that electric and/or chemical stimulation at various brain sites of experimental animals can raise regional cerebral blood flow and improve cerebral circulation; however, its mechanism is still unclear.OBJECTIVE: To observe the effects of electric stimulation at cerebellar fastigial nucleus on serum C-reactive protein of patients with acute cerebral infarction.DESIGN: Non-randomized synchronized contrast study.SETTING: The Second People's Hospital of Xinxiang City.PARTICIPANTS: A total of 54 patients with acute cerebral infarction were selected from the Department of Neurology, the Second People's Hospital of Xinxiang from December 2005 to December 2006. There were 31 males and 23 females, and their ages ranged from 56 to 80 years. All patients met the diagnostic criteria of the Fourth National Cerebrovascular Academic Meeting, were finally diagnosed by using CT examination,and provided the confirmed consent. Based on therapeutic demands, patients were divided into electric stimulation group and routine treatment group with 27 cases in each group. In addition, 21 healthy subjects,including 11 males and 10 females and aging 53 - 78 years, were selected as the control group. All the subjects in the control group did not have any histories of cerebrovascular diseases and severe body diseases.METHODS: Based on routine drug therapy, patients in the electric stimulation group were also treated by using CVFT-010M cerebral circulation function therapeutic device (made in Shanghai). Electrode was fixed at bilateral mastoid in the first group and at extensible sides of upper limbs in the second group. Electric stimulation was given twice a day and lasted for 30 minutes each time. Ten days were regarded as a course.Parameters of device: mode Ⅲ, frequency 198%, and intensity 90% - 110% (bionic current). Patients in the routine treatment group received the routine drug treatment. Content of serum C-reactive protein was measured in both

  6. Serum vitamin B12 and folic Acid levels in acute cerebral atherothrombotic infarction.

    Science.gov (United States)

    Kocer, Abdulkadir; Ince, Nurhan; Canbulat, Cuneyt E; Sargin, Mehmet

    2004-10-01

    Hyperhomocysteinemia is an independent risk factor for atherothrombotic cerebral stroke. Vitamin B12 and folic acid are important determinants of homocysteine metabolism. We aimed to evaluate the relationship, if present, between vitamin B12 and folic acid levels and acute cerebral stroke in this study. Blood aliquots drawn within 24 hours after the stroke from hospitalized patients (n=66) with the diagnosis of acute ischemic cerebrovascular episode and also blood samples from 38 healthy controls without any vascular risk factor were analyzed. With a competitive, chemoluminescence assay, serum levels of vitamin B12 and folic acid were measured in blood samples taken within 24 hours after the stroke. The differences and correlations were tested using frequency test, student-t test and multivariate analysis. Mean serum vitamin B12 levels were significantly lower in the patients than in the control subjects, 245.40 (S.D.: 72.9) and 343.2 (S.D.: 113.0) pg/ml respectively (p=0.0001). This difference was independent from other risk factors. Likewise, mean serum folic acid levels were lower in the patients than in the control subjects, 4.62 (S.D.: 1.94) and 5.97 (S.D.: 1.19) ng/ml, respectively (p=0.003). Mean serum levels of vitamin B12 and folate at the convalescence phase were 253.05 (S.D.: 68.78) pg/ml and 4.48 (S.D.: 2.08) ng/ml, respectively; the values obtained at the acute phase were not significantly different from the values obtained at the convalescence phase. We conclude that low vitamin B12 and folic acid concentrations are associated with an increased risk of stroke, and the relationship for vitamin B12 is independent from the other known modifiable stroke risk factors. For understanding the effects of B12 and folate in stroke patients, more detailed follow-up studies with long period are needed.

  7. A Clinical study on the treatment of Cerebral Infarct with Naloxone

    Institute of Scientific and Technical Information of China (English)

    Du Yanhua; Wan8 Jianmin; QuRuishcn

    2000-01-01

    OBJECTIVE: Naloxone and complex Danshen were used to treat cerebral infart in order to compare two groups′ Clinical effectiveness. BACKGROUND:The treatment of cervral infart with Naloxone is reported more often in abroad than in domestic. METHODS:144 cases were divided into two group randomly group treated with Naloxone: 74 cases (male 39 cases,female 33 cases,) average age 64.5yr. control group:70 cases (male 37 cases, female 33 cases), average age 65yr. 0.8mgNaloxone which was soluted in 250ml 0.9% Natrii chloride was used in the trcatment group by intravenous infusion, Qd, and the treatment lasted 14 days, On before and 4W and 8W both aftcr treatment, clotting time and blood flow dynamics were investigated. According to NDS and DLA standards, clinical effectiveness was compared and was studied by t test statistic method. RESULTS:Thc total response rate is 93.2% in Naloxonegroup, and 77.1% in control group (P<0. 05), The differencebetween two groups is statistically significant. CONCLUSION: The treatment of cercral infart with Naloxone is more effiecfive than with complex Danshen

  8. Monitoring the changes in plasm C-reactive protein,fibrinogen and blood white cell in patients with primary hypertension combined with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Yuanfei Deng; Juan Hang; Yane Chen

    2006-01-01

    BACKGROUND: Inflammatow reaction and the increased level of its accompanying active protein play an important role in the occurrence and development of cerebral infarction. C-reactive protein, fibrinogen and white blood cell, as the monitoring index of inflammatory reaction, are very important in the occurrence and development of acute cerebral infarction.OBJECTIVE: To make a comparison between patients with primary hypertension accompanied with acute cerebral infarction and with simple primary hypertension by observing the changes in plasma C-reactive protein and fibrinogen levels as well as white blood cell and differential counts and analyzing their significances.DESIGN : Controlled observation.SETTTNG: Ward Building for VIP, Shenzhen Hospital, Peking University.PARTICIPANTS: Totally 133 patients with primary hypertension were selected from Ward Building for VIP,Shenzhen Hospital, Peking University during September 2003 to September 2005. The diagnostic criteda were based on the hypertension diagnosis criteria formulated by the 7th World Health Organization-lnternational Society of Hypertension Guidelines (WHO-ISH) in 1998. The informed consents were obtained from all the participants. The involved patients were assigned into two groups: primary hypertension group, in which, there were 65 patients with primary hypertension ( degree 2), including 42 males and 23 females,with mean age of (61 ±14)years and mean blood pressure of (162.7±6.8)/(94.2±8.4) mm Hg(1 mm Hg =0.133 kPa), and primary hypertension combined with cerebral infarction group, in which, there were 68 patients with primary hypertension combined with cerebral infarction ( meeting the diagnostic criteria formulated in the 4th National Cerebrovascular Diseases Meeting in 1995 and diagnosed by skull CT or MRI to exclude the patients with lacunar infarction), including 42 males and 26 females, with mean age of (56±15)years and mean blood pressure of (176.4±9.2)/(96.3±9.7) mm Hg.METHODS: Plasm C

  9. Clinical features and etiology of cerebral infarction in children%儿童脑梗死的临床特点与病因分析

    Institute of Scientific and Technical Information of China (English)

    张俊梅; 杨凤华; 王华; 刘雪雁; 赵亚娟; 周晓薇

    2012-01-01

    Objective To summarize the clinical features and etiology of cerebral infarction in children.Methods The clinical data of 47 children with cerebral infarction who were hospitalized in Shengjing Hospital of China Medical University from Jan 2009 to Jul 2011 were analyzed retrospectively.Results There were 30 boys and 17 girls in all the 47 children.The median age of onset was 3.1 years(ranged from 2 months to 11 years old).Among 47 cases,the common neurological manifestations included limb paralysis in 32 cases(68.1% ),central facial paralysis in 15 cases(31.9% ),convulsion in 12 cases(25.5% ),disturbance of consciousness in 10 cases(21.3% ),and language disorders in 10 cases(21.3% ).Among 47 cases,31 cases had basal ganglia infarction with neuronal imaging( CT or MRI),of whom 4 cases accompanied with other location infarction.Several lobes of infarction in 5 cases,hemispheric infarction in 3 cases,parietal infarction in 2 cases,frontal lobe infarction in 2 cases,temporal lobe infarction in 2 cases,and thalamic infarction in 2 cases.Nineteen cases were carried out blood vessel imageology examination,11 cases showed abnormality,the most common affected cerebral blood vessel were middle cerebral artery(5 cases).The common causes of 47 cases were trauma ( 19 cases,40.4% ),infection( 12 cases,25.5% ) and moyamoya disease (5 cases,10.6% ).Ten children (21.3%) had no identifiable cause.Conclusion The common period of cerebral infarction is in infancy.The most frequent neurological symptom is hemiplegia.The most common region of infarction is in basal ganglia with neuronal imaging.The common causes of cerebral infarction are trauma,infection and moyamoya disease.%目的 总结儿童脑梗死的临床特点和病因.方法 对2009年1月至2011年7月在中国医科大学附属盛京医院住院的47例脑梗死患儿的病例资料进行回顾性分析.结果 47例患儿中,男30例,女17例;发病年龄2个月~11岁,平均3.1岁.常见的神经系

  10. Chronic and acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia.

    Science.gov (United States)

    Bernaudin, Françoise; Verlhac, Suzanne; Arnaud, Cécile; Kamdem, Annie; Vasile, Manuela; Kasbi, Florence; Hau, Isabelle; Madhi, Fouad; Fourmaux, Christine; Biscardi, Sandra; Epaud, Ralph; Pondarré, Corinne

    2015-03-05

    Early transcranial Doppler (TCD) screening of the Créteil sickle cell anemia (SCA)-newborn cohort, and rapid initiation of transfusion programs, resulted in successful prevention of overt strokes, but a high cumulative risk of silent cerebral infarcts (SCI) remained, suggesting that TCD screening does not identify all patients with SCA at risk for SCI. We hypothesized that episodes of hypoperfusion/hypoxia, as observed during acute chest syndromes or acute anemic events (AAE), and extracranial internal carotid artery (eICA) stenoses, detectable via submandibular Doppler sonography and cervical magnetic resonance angiography (MRA), could also be risk factors for SCI. This study includes 189 stroke-free patients with SCA from the Créteil newborn cohort (1992-2010) followed longitudinally by magnetic resonance imaging/MRA, including cervical MRA at the last assessment. All patients with abnormal TCD and/or intracranial stenoses were placed on a transfusion program. Mean follow-up was 9.9 years (range, 2.2-19.9 years; 1844 patient-years). Annual rates of clinical events were calculated. The cumulative risk for SCI was 39.1% (95% confidence interval [CI], 23.5%-54.7%) by age 18 years, with no plateau. We confirm that baseline hemoglobin level lower than 7 g/dL before age 3 years is a highly significant predictive risk factor for SCI (hazard ratio, 2.97; 95% CI, 1.43-6.17; P = .004). Furthermore, we show that AAE rate (odds ratio, 2.64 per unit increase; 95% CI, 1.09-6.38; P = .031) and isolated eICA stenosis (odds ratio, 3.19; 95% CI, 1.18-8.70; P = .023) are significant and independent risk factors for SCI.

  11. Nephroangiosclerosis in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: is NOTCH3 mutation the common culprit?

    Science.gov (United States)

    Guerrot, Dominique; François, Arnaud; Boffa, Jean-Jacques; Boulos, Nada; Hanoy, Melanie; Legallicier, Bruno; Triquenot-Bagan, Aude; Guyant-Marechal, Lucie; Laquerriere, Annie; Freguin-Bouilland, Caroline; Ronco, Pierre; Godin, Michel

    2008-08-01

    Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a systemic arterial disease characterized by impairment of vascular smooth muscle cell structure and function related to NOTCH3 mutations. Pathological findings include pathognomonic granular osmiophilic material (GOM) deposition with nonspecific hyalinization within the artery wall in a variety of tissues. The main clinical presentation is iterative strokes in young adults despite the lack of cardiovascular risk factors, leading to early dementia. Although arteriosclerosis and GOM have been found in kidneys from patients with CADASIL, kidney disease has been described only once up to now, in association with immunoglobulin A nephropathy. We report the case of a 61-year-old patient with a medical history of CADASIL and recent mild hypertension. His mother also showed neuropsychiatric symptoms and end-stage renal disease of unknown cause. The patient had a chronic kidney disease defined by means of estimated glomerular filtration rate using the 4-variable Modification of Diet in Renal Disease Study equation of 58 mL/min/1.73 m(2) associated with mild proteinuria and intermittent microscopic hematuria. Renal histological analysis showed severe arteriosclerosis and mild interstitial fibrosis. Glomeruli did not show mesangial immunoglobulin A deposition or focal segmental proliferation. Electron microscopic analysis showed typical GOM deposition in the vicinity of altered vascular smooth muscle cells in interlobular and juxtaglomerular arteries. The nephroangiosclerosis-like lesions were unusually severe in contrast to the recent mild hypertension. The presence of GOM strongly suggests that renal lesions were related to the NOTCH3 mutation. Here, we describe the first case of familial occurrence of kidney disease with decreased kidney function in the absence of coexisting nephropathy in patients with CADASIL. We discuss the role of NOTCH3 mutation in the pathogenesis

  12. Focal cerebral ischemia induces increased myelin basic protein and growth-associated protein-43 gene transcription in peri-infarct areas in the rat brain

    DEFF Research Database (Denmark)

    Gregersen, R; Christensen, Thomas; Lehrmann, E;

    2001-01-01

    , in peri-infarct areas in adult rat brain after transient middle cerebral artery occlusion (MCAO) and correlated it to the expression of the growth-associated protein-43 (GAP-43), a marker for axonal regeneration and sprouting, using non-radioactive in situ hybridization techniques. Within the infarct, MBP......, corresponding to the appearance of process-bearing MBP and occasional MOG-immunoreactive oligodendrocytes in parallel sections. Quantitative analysis revealed significant increases in the density of oligodendrocytes (up to 7.6-fold) and in the level of MBP mRNA expressed by individual cells. Parallel sections...... showed that increased expression of GAP-43 mRNA in neurons was concomitant to MBP mRNA upregulation in oligodendrocytes. While the mechanisms regulating oligodendrocyte survival and myelination signals are not clear at this point, axonal sprouting could putatively serve as a stimulus for the upregulation...

  13. Study on Related Factors of Recurrent Cerebral Infarction%复发性脑梗死相关因素研究

    Institute of Scientific and Technical Information of China (English)

    王娟

    2013-01-01

    目的 探讨复发性脑梗死的相关因素.方法 选取2008年1月-2010年12月191例复发性脑梗死患者及525例同期入院的首发脑梗死患者的临床资料进行对照分析,并对其相关因素进行多因素非条件Logistic回归分析.结果 两组性别构成,糖尿病、饮酒、肾功能不全及蛋白尿发生率,血小板计数、同型半胱氨酸、尿酸、肌酐、C反应蛋白、空腹血糖、总胆固醇、三酰甘油、低密度脂蛋白及高密度脂蛋白水平比较,差异均无统计学意义(P>0.05).复发组年龄>60岁、有脑梗死家族史者所占比例,高血压、冠心病、吸烟、心房纤颤、慢性支气管炎及高纤维蛋白原发生率与对照组比较,差异均有统计学意义(P<0.05).进一步进行多因素非条件Logestic回归分析,其中年龄>60岁[OR=2.021,95%CI(1.336,3.058),P=0.001]、高血压[OR=1.717,95%CI(1.054,2.796),P=0.030]、高纤维蛋白原[OR=1.492,95%CI(1.048,2.123),P=0.026]进入回归方程.结论 脑梗死复发是多因素的,年龄>60岁、高血压、高纤维蛋白原是复发性脑梗死的主要危险因素,针对可控制因素的治疗是预防脑梗死复发的重要途径之一.%Objective To explore the risk factors for recurrent cerebral infarction. Methods Clinical data of 191 patients with recurrent cerebral infarction and 525 patients with first time cerebral infarction from January 2008 to December 2010 were comparatively analyzed and multivariate unconditional Logistic regression analysis were used to analyze related factors. Results The sex ratio, diabetes, drinking, renal insufficiency, incidence of proteinuria, platelet count, homocysteine (HCY), uric acid, creatinine, C - reactive protein, fasting blood glucose, total cholesterol, triacylglycerol, LDL and HDL showed no statistically significant differences between the two groups ( P > 0. 05 ) . Compared with control group, age > 60 , history of cerebral infarction, hypertension, coronary disease

  14. 新生儿脑梗死临床分析%The Clinical Analysis of Neonatal Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    侯晓静; 张成元

    2016-01-01

    Objective To analyze the epidemic factors, clinical characteristics and prognosis of neonatal cerebral infarction(NCI),Conclude the intervention measures and Improve the awareness of the disease. Methods Clinical records of 6 confirmed cases from October 2014 to October 2015 at Weifang City Maternal and Child Care Service Centre were enrolled, all cases underwent DWI examination in addition to conventional MRI examination [T1-weighted (T1W) and T2-weighted (T2W)] within 7 days after birth. Four cases received the second MRI examination after treatment of 10 to 14 days. Results Within one year,6 neonates with cerebral infarction were found in the hospital,including 4 cases of male and 2 cases of female ,5 term infants and 1 preterm infants , 4 infants with cesarean delivery and 2 with vaginal delivery.Convulsion as the first symptom were noted in 2 neonates,(one with frequent convulsion of double lower limbs, and anther with limb trembling), one case showed muscular hypertonia, 3 cases without any clinical symptoms. 6 neonates were discharged from hospital after recovery, only one case was found normal within 6 months of follow-up and the other four had obvious unfavorable prognoses, ons,s discharge time is short. The first imaging examination (within 7days)showed a slight hypointensity on T1W, a slight hyperintensity on T2W and significantly increased signal intensity with a clear boundary on DWI in the lesions. In the MRI re-examination, more obvious hypointensity on T1W and hyperintensity on T2W were noted, while hyperintensity was shown on DWI in the lesions compared with the first imaging results. Conclusion The signs and symptoms of NCI are non-specific, Needing to consider the possibility of NCI for those infants who have a sudden convulsion. MRI is the gold standard of diagnosis of NCI. A hyper intensity on DWI was shown in the lesions at the early stage of neonatal cerebral infarction. A hypointensity on T1W and a hyperintensity on T2W were demonstrated in

  15. 老年糖尿病合并脑梗死护理分析%Nursing Care of Senile Diabetes Complicated With Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    杨忠坤; 杨秀芝

    2016-01-01

    目的:探讨对患有糖尿病合并脑梗死的高龄患者实施综合性护理对治疗的影响程度。方法收集我院治疗患有糖尿病合并脑梗死的高龄患者40例作为研究对象。研究组选择综合性护理方法,对照组实施基础护理。结果研究组空腹血糖下降程度大于对照组,患者的神经功能评分高于对照组。结论对有糖尿病合并脑梗死的高龄患者,进行综合性护理可以提高治疗的效果。%Objective To discuss the effect of comprehensive nursing for elderly diabetes patients complicated with cerebral infarction. MethodsCollected 40 elderly diabetes patients complicated with cerebral infarction in our hospital as the research object. The study group received comprehensive nursing methods, the control group received real-time basic nursing.Results In the study group, the fasting blood glucose decreased more than the patients in the control group, the neurological function score was higher than the control group.Conclusion For elderly diabetes patients complicated with cerebral infarction, the comprehensive nursing care can improve the therapeutic effect.

  16. Clinical Analysis of 52 Patients with Massive Cerebral Infarction%大面积脑梗死52例临床分析

    Institute of Scientific and Technical Information of China (English)

    李伟; 俞建军

    2011-01-01

    目的:提高大面积脑梗死诊断、治疗水平,降低病死率和致残率.方法:对我院2005~2009 年收治的52 例大面积脑梗死的临床资料进行总结分析.结果:好转35 例(67.31%),无变化8例(15.38%),死亡9例(17.31%).结论:认为高血压病、糖尿病、冠状动脉粥样硬化性心脏病、心脏瓣膜病、高血脂等为其主要病因,结合临床表现和影像学特征有助于早期诊断,早期降颅内压,积极处理并发症、基础病,外科治疗均有助于降低病死率和致残率.%Objective: To improve the levels of diagnosis and treatment for patients with massive cerebral infarction, so that to reduce the mortality and disability due to massive cerebral infarction. Methods: Clinical data of 52 cases With cerebral infarction were summarzed and analysed, and all subjects were hospitalized in our hospital from 2005 to 2009. Results: There were 35 patients improved (67.31%),8 cases unchanged (15.38%), and 9 patients died (17.31%). Conclusion: Hypertension, diabetes, coronary heart disease, heart valve diseaes and hyperlipids are regarded as main pathogeny, and early diagnosis is done by means of clinical manifestations and imaging features. The mortaliy and disability are reduced via early decreasing intracranial pressure, actively dealing with complications, underlying diseases, and surgival treatment.

  17. 尼麦角林治疗脑梗死后抑郁的疗效观察%Curative effect of nicergoline on depression after cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    鲍治诚; 王万华; 夏雪龙

    2014-01-01

    目的:观察尼麦角林治疗脑梗死后抑郁的疗效。方法将100例脑梗死后抑郁患者随机分成观察组50人,对照组50人。观察组口服尼麦角林片,对照组口服谷维素片,疗程8周,治疗前后采用汉密尔顿抑郁量表(HAMD)评分,判断疗效并观察不良反应。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05)。结论尼麦角林能明显改善脑梗死后抑郁症状。%Objective To observe the effect of nicergoline on depression after cerebral infarction. Methods 100 cases of depression after cerebral infarction were randomly divided into two groups.The numbers of treatment group and control group were 50 each.The treatment group took nicergoline tablets for 8 weeks,and the control group took oryzanol tablets for 8 weeks.Before and after treatment,Hamilton's Depression Scale (HAMD) was used to estimate the effect and observed the adverse reaction. Results The overall response rate of the treatment group was significantly higher than the control group (P<0.05). Conclusion Nicergoline can improve the symptom of depression after cerebral infarction effectively.

  18. Effects of KR-33028, a novel Na+/H+ exchanger-1 inhibitor, on glutamate-induced neuronal cell death and ischemia-induced cerebral infarct.

    Science.gov (United States)

    Lee, Bo Kyung; Lee, Dong Ha; Park, Sok; Park, Sung Lyea; Yoon, Jae-Seok; Lee, Min Goo; Lee, Sunkyung; Yi, Kyu Yang; Yoo, Sung Eun; Lee, Kyung Hee; Kim, You-Sun; Lee, Soo Hwan; Baik, Eun Joo; Moon, Chang-Hyun; Jung, Yi-Sook

    2009-01-12

    We investigated the effects of a novel Na(+)/H(+) exchanger-1 (NHE-1) inhibitor KR-33028 on glutamate excitotoxicity in cultured neuron cells in vitro and cerebral infarct in vivo by comparing its potency with that of zoniporide, a well-known, highly potent NHE-1 inhibitor. KR-33028 inhibited NHE-1 activation in a concentration-dependent manner (IC(50)=2.2 nM), with 18-fold greater potency than that of zoniporide (IC(50)=40.7 nM). KR-33028 significantly attenuated glutamate-induced LDH release with approximately 100 times lower EC(25) than that of zoniporide in cortical neurons in vitro (EC(25) of 0.007 and 0.81 microM, respectively), suggesting its 100-fold greater potency than zoniporide in producing anti-necrotic effect. In addition, the EC(50) of KR-33028 for anti-apoptotic effect was 100 times lower than that of zoniporide shown by TUNEL positivity (0.005 and 0.62 microM, respectively) and caspase-3 activity (0.01 and 2.64 microM, respectively). Furthermore, the EC(50) value of KR-33028 against glutamate-induced intracellular Ca(2+) overload was also 100 times lower than that of zoniporide (EC(50) of 0.004 and 0.65 microM, respectively). In the in vivo cerebral infarct model (60 min middle cerebral artery occlusion followed by 24 h reperfusion), KR-33028 reduced infarct size in a dose-dependent manner. Its ED(25) value, however, was quite similar to that of zoniporide (ED(25) of 0.072 and 0.097 mg/kg, respectively). Hence these results suggest that the novel NHE-1 inhibitor, KR-33028, could be an efficient therapeutic tool to protect neuronal cells against ischemic injury.

  19. Early Identification and Nursing of Patients with Severe Cerebral Infarction%重症脑梗死患者的早期识别与护理

    Institute of Scientific and Technical Information of China (English)

    邵慧; 刘美玲

    2014-01-01

    Objective:To discuss the early identification and nursing methods for patients with severe cerebral infarction,to summarize nursing experience. Method:Retrospectively analyzed the data of 8 patients with severe cerebral infarction. Result:In the 8 patients,7 patients improved and discharged. Their localizing symptoms of the nervous system as well as physical signs were alleviated for varying degrees and entered convalescent rehabilitation phase. 1 patient had once improved after rescue measures. However,for the family members were not cooperative with the treatment and rescue,the patient finally automatically discharged due to multiple organ failure. Conclusion:Early identifying patients with severe cerebral infarction and promptly taking effective nursing measures can enhance rescue success rate and improve the prognosis.%目的:探讨重症脑梗死患者的早期识别信号与护理措施,总结护理经验。方法:对8例重症脑梗死患者资料作回顾性分析。结果:8例患者中,7例好转出院,其神经系统的定位症状与体征均有不同程度的减轻,进入恢复期康复阶段;1例经积极抢救,病情曾一度好转,但由于家属的不配合治疗和抢救,最终因多脏器衰竭自动出院。结论:对重症脑梗死患者进行早期识别,及时采取有效的治疗护理措施可以提高抢救成功率,改善预后。

  20. Evaluation of Risk Factors of Transient Ischemic Attack Progressing into Cerebral Infarction(review)%短暂性脑缺血发作进展为脑梗死的危险因素评估

    Institute of Scientific and Technical Information of China (English)

    薛嫱; 马欣

    2011-01-01

    Transient ischemic attack (TIA) is not only an ischemic cerebrovascular disease with high incidence, but also a risk warning signal of cerebral infarction. This article reviewed the correlation of TIA and cerebral infarction, risk factors of transient ischemic attack progressing into cerebral infarction and its score scale.%短暂性脑缺血发作是发病率较高的缺血性脑血管病,也是脑梗死的危险预警信号.本文就短暂性脑缺血发作与脑梗死的相关性、进展为脑梗死的危险因素及量表评估进行综述.

  1. 急性脑梗死患者合并脑微出血的静脉溶栓治疗%Intravenous thrombolysis in acute cerebral infarction with cerebral microbleeds

    Institute of Scientific and Technical Information of China (English)

    林清原; 杨继党

    2014-01-01

    Objective To investigate the influence of intravenous thrombolysis to acute cerebral infarction with cerebral microbleeds (CMB). Methods Eight-nine patients with cerebral infarction in the Neurological Department of the Second Affiliated Hospital of Guangzhou Medical College from January 1st , 2011 to December 31st, 2012 were enrolled in this study. All patients were scanned with MRI and GRE. According to the presence of CMB, the patients were classified into two groups, including CMB group and non-CMB group. Past history of smoking, drinking, hypertension, lacunar infarction, diabetes and leukoaraiosis situation were recorded and risk factors of CMB were explored. All patients were treated with intravenous thrombolysis and rescanned with MRI to compare the total number of CMB 24 hours after thrombolysis. Results In the CMB group, the number of patients with mild CMB decreased and the number of patients with serious CMB increased after thrombolysis. CMB was associated with sex, age, hypertension, lacunar infarction and leukoaraiosis. Conclusions Sex, age, hypertension, lacunar infarction and leukoaraiosis were the risk factors of CMB in acute cerebral infarction. Thrombolysis in acute cerebral infarction augments the incidence of CMB and promotes the hemorrhagic transformation.%目的:探讨急性脑梗死合并脑微出血(CMB)的患者在静脉溶栓后脑微出血的变化。方法:收集2011年1月1日至2012年12月31日在广州医学院第二附属医院神经内科住院的89例急性脑梗死患者,入院时均行常规 MRI 加梯度回波序列 T2加权检查,根据是否存在 CMB 分为有 CMB 组、无 CMB 组。记录两组患者的吸烟、饮酒、高血压、腔隙性脑梗死、糖尿病、白质疏松等既往史,并探讨CMB 的危险因素。患者经溶栓治疗后,观察CMB数目的变化。结果:经溶栓治疗后24 h复查,有CMB 组的CMB 个数与治疗前相比,轻度CMB 患者减少,重度CMB 患者增多;性

  2. Clinical Application of CT Cerebral Perfusion and Angiography in Acute Cerebral Infarction%CT脑灌注与血管造影在急性脑梗死中的临床应用

    Institute of Scientific and Technical Information of China (English)

    娄雪磊

    2015-01-01

    目的:探讨CT脑灌注与血管造影在急性脑梗死中的临床应用效果。方法选择医院2014年12月~2015年6月诊治的急性脑梗死患者中抽取75例作研究对象,对其分别进行CT脑灌注和血管造影检查,对比两种检查方法的诊断情况。结果 CT灌注图内,对应患者的临床症状的灌注异常处有63例,其阳性率是84.0%,高于CT检测的19例,其阳性率是25.3%(P<0.05);同时,经CT脑灌注和血管造影检测发现,责任血管者采取CT脑灌注检测阳性者48例,其阳性率是64.0%,无责任血管者13例,其阳性率是17.3%(P<0.05)。结论 CT脑灌注与血管造影在急性脑梗死中的临床应用效果确切,有助于为急性脑梗死预防、治疗措施的制定提供参考依据。%Objective To study the clinical application effect of CT cerebral perfusion with angiography in acute cerebral infarction.Methods In a hospital in December 2014 to June 2015 in the diagnosis and treatment of acute cerebral infarction patients from 75 cases as the research object,the CT cerebral perfusion and angiography respectively,compared to two kinds of inspection methods of diagnosis.ResultsCT perfusion in the figure, the corresponding clinical symptoms in patients with perfusion abnormalities in 63 cases,the positive rate was 84.0%,significantly higher than that of CT detection of 19 cases,the positive rate was 25.3%(P<0.05,at the same time,CT cerebral perfusion and angiographic examination found that responsibility vessels take CT cerebral perfusion was 48 cases,the positive rate was 64.0%,significantly less responsibility 13 cases of blood vessels,the positive rate was 17.3%(P<0.05). ConclusionCT cerebral perfusion with angiography in acute cerebral infarction clinical application effect of precise,help for acute cerebral infarction,to provide the reference basis for the establishment of prevention and treatment measures.

  3. 脑梗塞患者的血脂水平分析%Analysis of serum lipid levels in patients with cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    季春雨; 万义增

    2013-01-01

    目的:探讨脑梗塞患者的血脂水平及其相关性。方法:选择脑梗塞患者60例为观察组,同期选择正常健康人60例为对照组,两组都进行血脂四项指标的检测。结果:观察组的TC、TG与LDL-C含量明显高于对照组,而HDL-C含量明显低于对照组(P<0.05)。观察组中高胆固醇血症15例,高甘油三酯血症19例,高低密度脂蛋白血症14例,低高密度脂蛋白血症12例,且TC、TG、LDL-C与HDL-C含量与脑梗塞发病都有明显相关性(P<0.05)。结论:脑梗塞患者多伴随有血脂紊乱,为此在预防中要积极控制血脂水平。%Objective:To study the serum lipid levels in patients with cerebral infarction and the relative between the levels and the patients. Methods:60 patients with cerebral infarction were selected as observation group, 60 healthy people were selected as control group. The four parameters of blood lipids were detected in two groups. Results:The content of TC, TG and LDL-C in the people of the observation group were significantly higher than the observation group, and the content of HDL-C was significantly lower than the observation group. There were 15 patients with hypercholesterolemia, 19 patients with hypertriglyceridemia, 14 patients with low density lipoproteins and 12 patients with low HDL-C. It was significant correlation between the content of TC, TG, LDL-C and HDL-C with the cerebral infarction(P<0.05).Conclusion:Patients with cerebral infarction usual y accompanied by lipid disorders, therefore the actively control of the blood lipid level is very important for prevention.

  4. Analysis of Type 2 Diabetes Mellitus Complicated with Cerebral Infarction%2型糖尿病合并脑梗塞的临床分析

    Institute of Scientific and Technical Information of China (English)

    胡培明

    2011-01-01

    目的:探讨2型糖尿病合并脑梗塞的临床特点及防治措施.方法:将110例患者分为脑梗塞合并糖尿病组及非糖尿病脑梗塞组.两组均采用吸氧、控制血压、降低颅压、保护脑功能、纠正酸碱平衡和水电解质紊乱等基础治疗.合并糖尿病组同时控制血糖疗法,连续治疗3周.结果:糖尿病合并组60例中治愈9例、显效15例、好转21例、无效15例,总有效率为75%;对照组50例中治愈15例、显效12例、好转16例、无效7例,总有效率为86%,两组比较P < 0.05.结论:早期控制好血糖,实行降脂降压,改善血小板聚集等综合治疗措施是减少脑梗塞并发率及致死率、提高患者生存质量的关键.%To explore type 2 diabetes with clinical features of cerebral infarction and control measures. Method: 110 cases of cerebral infarction with diabetes were divided into diabetic group and nondiabetic patients with cerebral infarction. Both groups were given oxygen, control of blood pressure, reduce intracranial pressure, protecting brain fanetion, correct the acid-base balance and electrolyte disturbance and other basic water treatment. Group while controlling blood sugar diabetes therapy, continuous treatment for 3 weeks. Result: The diabetic group, 60 cases were cured in 9 eases, 15 cases were significantly improved in 21 eases, 15 patients, the total effective rate was 75%; control group, 50 cases were cured in 15 cases, markedly effective in 12 cases, 16 cases were improved, invalid 7 , the total effective rate of 86% respeefively, P <0.05. Conclusion: The early good blood sugar control, the implementation of lipid-lowering blood pressure, platelet aggregation, improve the comprehensive treatment of concurrent measures to reduce cerebral infarction and mortality rates, the key to improving the quality of life of patients.

  5. 脑梗死患者心理状态临床分析及对策%Clinical Analysis of the Psychological Problems of Cerebral Infarction Patients

    Institute of Scientific and Technical Information of China (English)

    王道英

    2009-01-01

    Objective To study the cerebral infarction patients with psychological problems,so that patients maintain the best psychological state,actively cooperate with the treatment of disease and recover early. Methods 90 eases of cerebral infarction patients by age group is divided into youth and old age group. From the perspective of their care from clinical data,looking for different age groups of patients with psychological problems,for different psychological problems,with psychological support,psychological counseling and active listening to the method of kneading and the patients with psychological support. Results The psychological state of patients with cerebral infarction and age are closely related. Conclusion According to different ages for different psychological care to patients with cerebral infarction implementation of the measures can effectively reduce the complications and sequel someway, improving the quality of life earlier.%目的 探讨脑梗死患者的心理问题,使患者保持最佳的心理状态,积极配合治疗.促进疾病早日康复.方法 将90例脑梗死患者按年龄分为青年组和老年组.从护理角度对其临床资料进行分开,寻找不同年龄组患者的心理问题,针对不同的心理问题,用心理安慰、心理疏导和积极倾听相揉和的方法,对患者进行心理支持.结果 脑梗死患者的心理状态与年龄密切相关.结论 根据不同年龄,针对不同心理状态对脑梗死患者实施护理能早期有效的康复训练,一定程度上降低并发症、后遗症.提高生活质量.

  6. A Case Report of Extensive Cerebral Infarction in Children%儿童大面积脑梗死一例报告

    Institute of Scientific and Technical Information of China (English)

    赵晓云; 宋维旭; 马永德; 王君霞

    2011-01-01

    目的 提高对儿童脑梗死的认识,以降低致死、致残率.方法 回顾分析1例儿童大面积脑梗死的临床资料.结果 患儿因右侧肢体无力9个月余,抽搐1次收入院.曾于外院行颅脑磁共振动脉造影( MRA)检查示右侧额叶后部、颞顶叶、岛叶及左侧基底核区脑梗死.入我院4h后患儿意识进行性恶化至深昏迷,双侧瞳孔不等大,对光反射消失.急诊行颅脑MR检查示右侧大脑中动脉供血区急性脑梗死;左侧基底核区陈旧性脑梗死;脑疝形成.家属放弃治疗,患儿出院.于离院后4h死亡.结论 儿童脑梗死的常见病因有感染、外伤、血管畸形、全身性疾病及动脉发育不良等,治疗原则同成人,对明确病因的患儿应同时加强病因治疗.%Objective To raise the awareness of cerebral infarction in clildren to induce mortality and morbidity rates. Methods Retrospective analysis of the clinical date of one case of extensive cerebral infarction in children was conducted. Results The child was admitted to the hospital with the right limb weakness for 9 months, and with onset of seizure attack. The brain magnetic resonance angiography (MRA) examination in the previous hospital revealed that the back of the right frontal lobe, temporal lobe, insula and left basal ganglia had infarction. Four hours after admission, the awareness of child progressively deteriorated into deep coma, bilateral pupils appeared in differents sizes, and light reflex disappeared. E-mergency MR imaging of brain showed that the right middle cerebral artery territory had acute cerebral infarction and hernia-tion, and the left basal ganglia area had chronic infarction. The parents of the child abandoned treatment and the child died 4 h after discharge. Conclusion The common causes of cerebral infarction in children are infection, trauma, vascular malformations, systemic disease and arterial dysphasia. The treatment principles are no different from that of adults

  7. Correlation between special brain area and blood perfusion in patients with cerebral infarction at convalescent period Feasibility for quantitative determination and estimation of learning and memory function

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: Presently, clinic memory scale is used to evaluate learning memory ability in most studies,and the influence of difference in measurement condition of individuals exists.OBJECTIVE: To study the correlation between regional cerebral blood flow (rCBF) perfusion and learning memory function in special brain regions of patients with cerebral infarction at convalescent period,and to try to find out a method which can quantitatively evaluate learning ability.DESIGN: Case observation, and correlation analysis.SETTINGS: Shandong Institute for Behavioral Medicine; the Affiliated Hospital of Jining Medical College.PARTICIPANTS: Totally 70 patients with cerebral infarction admitted to Departtment of Neurology, Jining Medical College between January 2004 and December 2005 were involved. The involved patients, 58 male and 12 female, were averaged (52±3) years, and they were all right handed. They all met the diagnosis criteria instituted by the Fourth National Conference on Cerebrovascular Disease, and were confirmed as cerebral infarction by skull CT or MRI. Informed consents of detected items were obtained from all the patients and relatives.METHODS: When the patients were at convalescent period, their learning and memory ability were measured with" clinic memory scale (set A)". The 18 patients whose total mark over 100 were regarded as good learning memory function group; The 23 cases whose total mark less than 70 were regarded as poor learning memory function group. RCBF of hippocampus, nucleus amygdalae, temporal cortex and prefrontal lobe of patients between two groups were measured and compared by single photon emission computed tomography (SPECT). The total scores of the 18 good learning memory patients and 23 poor learning memory patients were taken as dependent variable Y, and their rCBFs of hippocampus, nucleus amygdale,temporal cortex and prefrontal lobe respectively as independent variable X for linear correlation analysis.MAIN OUTCOME MEASURES

  8. 糖尿病脑梗死与高血压脑梗死患者临床特点的对比分析%Comparative analysis of the clinical characteristics in patients with dia-betic cerebral infarction and hypertensive cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    吴育林

    2016-01-01

    Objective To compare and research on the clinical characteristics of patients with diabetic cerebral infarc-tion and hypertensive cerebral infarction.Methods From October 2014 to January 2016,162 patients with cerebral in-farction admitted into our hospital were retrospectively analyzed.Among them,42 cerebral infarction patients with dia-betes and hypertension were selected as observation group one;40 cerebral infarction patients with diabetes were select-ed as observation group two,40 cerebral infarction patients with hypertension were chosen as observation group three, and the 40 healthy volunteers in the same period were considered as control group.The levels of blood glucose,blood pressure,and blood lipid,renal function,and prognosis in acute stage were compared and analyzed.Results The blood glu-cose in the observation group one was much higher than that in the observation group two.The systolic blood pressure, diastolic blood pressure,and mean blood pressure in the observation group one were remarkably increased compared with those in observation group three (P﹤0.05).The blood urea nitrogen (BUN) and creatinine (Cr) were both increased among the three cerebral infarction groups in compared with those in the control group.Among these three cerebral in-farction groups,BUN and Cr in the observation group one were greatly increased (P﹤0.05).In comparison with the normal control group,low-density lipoprotein cholesterol (LDL-C),triglyceride (TG),total cholesterol (TC),and apolipoprotein-B (APO-B) were greatly increased,while high-density lipoprotein cholesterol (HDL-C) and APO-A were sharply de-creased (P﹤0.05).The therapeutic effective rate in the observation group one was much lower in comparison with the other two cerebral infarction groups (P﹤0.05).Conclusion Diabetes mellitus and hypertension are risk factors leading to abnormal renal function and lipid metabolism in patients with cerebral infarction.The prognosis is worst in cerebral in-farction

  9. The effects of early diagnosis of large area cerebral infarction on nerve function recovery%大面积脑梗死的早期诊断对神经功能恢复的影响

    Institute of Scientific and Technical Information of China (English)

    刘雅英; 杨毅光

    2002-01-01

    Background: Because there are acute occurrence and severe clinical findings in large area cerebral infarction, early diagnosis is very significant to early treatment and nerve function recovery. Objective: To discuss the effects of early diagnosis of large area cerebral infarction on nerve function recovery. Unit: Department of Urology, Second Hospital of Changtu County in Liaoning Province. Subjective: The cases in the research came from 132 patients with cerebral infarction identified by CT examination during 1995~ 2000, including 59 males and 73 females. The ages ranged from 37 to 72 years old, and mean age was 59. There were 78 patients who were troubles with hypertension past, 41 diabetes and 62 coronary heart diseases with atrial fibrillation. 132 patients entered the hospital in the episode day, and other 4 patients did 24 hours after the episode day. In the patients, there were 132 appeared with complete hemiplegia, 87 with different level conscious disturbance ( 60 somnolence and lethargy, 27 coma ), 76 accompanied with anepia, 93 with headache and vomiting, 36 with tic, 33 with ocular disturbance, 64 identified as papilledema, and 26 appeared with cerebral symptoms, 37 occurred metula hemorrhage. Intervention: All the 132 patients accepted cerebral CT examination within 24 hours since the onset of illness, and decreasing intracranial pressure,thrombolysis,protecting brain cells,anti-inflammation treatments. Result: There were large area low-density focuses in the blood-supplied region of middle cerebral artery and internal jugular vein in 19 patients' CT films 10 hours after onset of illness, and in addition 8 cases were transferred to surgery department for cerebral hernia. 37 patients with cerebral hemorrhage after infarction accepted neutrality therapy, and the symptoms relieved obviously for 29 days in the hospital. 69 patients restored conscious disturbance and muscular force of the troubled limbs notably, 29 cases left the hospital automatically

  10. Transplanted bone marrow stem cells relocate to infarct penumbra and co-express endogenous proliferative and immature neuronal markers in a mouse model of ischemic cerebral stroke

    Directory of Open Access Journals (Sweden)

    Liu Wei

    2010-10-01

    Full Text Available Abstract Background Several studies demonstrate that neurogenesis may be induced or activated following vascular insults, which may be important for neuronal regeneration and functional recovery. Understanding the cellular mechanism underlying stroke-associated neurogenesis is of neurobiological as well as neurological/clinical relevance. The present study attempted to explore potential homing and early development of transplanted bone marrow stem cells in mouse forebrain after focal occlusion of the middle cerebral artery, an experimental model of ischemic stroke. Results Bone marrow stem cells isolated from donor mice were confirmed by analysis of surface antigen profile, and were pre-labeled with a lipophilic fluorescent dye PKH26, and subsequently transfused into recipient mice with middle cerebral artery coagulation. A large number of PKH26-labeled cells were detected surrounding the infarct site, most of which colocalized with immunolabelings for the proliferating cell nuclear antigen (PCNA and some also colocalized with the immature neuronal marker doublecortin (DCX during 1-2 weeks after the bone marrow cells transfusion. Conclusions The present study shows that transplanted bone morrow cells largely relocate to the infarct penumbra in ischemic mouse cerebrum. These transplanted bone marrow cells appear to undergo a process of in situ proliferation and develop into putative cortical interneurons during the early phase of experimental vascular injury.

  11. Effects of tanshinone Ⅱ sodium sulfonate plus cinepazide maleate on the hemorrheologic indexes and blood lipids in patients with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Chunliang Li; Mingzhu Zhang; Haijun Zheng; Fengzhi Xue

    2007-01-01

    BACKGROUND: The severity of cerebral infarction is associated with the increase of blood viscosity caused by hyperfibrinogenemia and hyperlipidemia, etc. Thus it has become one of the target for treating cerebral infarction to decrease blood viscosity by integrated Chinese and western medicine.OBJECTIVE: To investigate the influence and clinical therapeutic effects of cinepazide maleate combined with tanshinone Ⅱ A sodium sulfonate on the hemorrheologic indexes and blood lipids of patients with acute cerebral infarction, and compare the results with those of simple cinepazide maleate treatment.DESIGN: A non-randomized case-controlled observation.SETTINGS: Hebei North University; the Second Affiliated Hospitals of Hebei North University; the Third Affiliated Hospitals of Hebei North University.PARTICIPANTS: Eighty-six inpatients with cerebral infarction were selected from the infirmary, the Second and Third Affiliated Hospitals of Hebei North University from September 2004 to October 2006.They were all diagnosed to have acute cerebral infarction by CT or MRI, and accorded with the diagnostic standards for acute cerebral infarction set by the Fourth National Academic Meeting for Cerebrovascular Disease in 1995. Meanwhile, 40 teachers and medical staff of voluntary physical examinees were selected as the control group. Informed contents were obtained from all the patients and their relatives.METHODS: The patients were divided into combined treatment group (n=43) and simple treatment group (n=43). In the combined treatment group, the patients were administrated with 160 mg cinepazide maleate injection (Beijing Four-ring Pharmaceutical, Co.,Ltd, No. H200220125; 80 mg/2 mL) added in 5% glucose,and 40 mg tanshinone Ⅱ sodium sulfonate (Shanghai No.1 Biochemical & Pharmaceutical Co.,Ltd., No.H31022558, 10 mg/2 mL) added in 250 mL normal saline. In the simple treatment group, the patients were only administrated with cinepazide maleate 320 mg added in 5% glucose or

  12. Correlation of Sleep Quality, Life Event with Cerebral Infarction%睡眠质量、生活事件与新发脑梗死关系的研究

    Institute of Scientific and Technical Information of China (English)

    曾思琳; 郭毅; 蔡智立; 杨焱; 梁宇彬; 常鑫

    2016-01-01

    Objective To explore the impact of life event stimulation and sleep quality on the incidence of cerebral infarction, and to further study its impact on the severity of cerebral infarction and post-stroke mood disorder. Methods The patients with cerebral infarction and subjects without cerebral infarction were enrolled into the study. The general clinical data of two groups were compared to analyze the risk factors of cerebral infarction. The Pittsburgh Sleep Quality Index (PSQI) was used to assess the 1-month sleep quality before cerebral infarction and life event stimulation assessment was performed by using Life Event Scale (LES). The Hamilton Depression Scale and the Hamilton Anxiety Scale were used in the first week of hospitalization to evaluate the emotional disorder. National Institutes of Health Stroke Scale (NIHSS), and Activity of Daily Living Scale (ADL) were used to evaluate the severity of the illness. Results A total of 95 patients were enrolled in the cerebral infarction group and 85 patients were enrolled in the control group. Univariate analysis showed that the scores of LES in the cerebral infarction group were signiifcantly higher than those in the control group [6.00 (14.00)vs 0.00 (6.25), P Conclusion Life event and poor sleep quality have impact on the incidence of cerebral infarction. Negative life event, sleep duration and diastolic blood pressure are the independent risk factors of cerebral infarction. Sleep disorders before the onset of cerebral infarction may lead to more severe symptoms of post-stroke depression.%目的探讨生活事件刺激及睡眠质量对脑梗死发病的影响,并进一步研究其对脑梗死严重程度及卒中后情绪障碍的影响。  方法入组新发脑梗死患者与非脑梗死患者(对照组),比较两组的一般临床资料,分析脑梗死的危险因素,采用匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)量表进行病前1个月睡眠质量评

  13. Reduced Serum Level of Interleukin-10 is Associated with Cerebral Infarction: A Case-Control and Meta-Analysis Study.

    Science.gov (United States)

    Zhu, Yifei; Yang, Haiqing; Diao, Zengyan; Li, Yi; Yan, Chuanzhu

    2016-05-01

    IL-10 expression limits inflammation and restricts the size of CNS damage from stroke. In this study, we examined the correlation between cerebral infarction (CI) and serum levels of interleukin-10 (IL-10) using a combination of case-control study and meta-analysis of published data, with an aim of understanding the relevance of serum IL-10 levels to CI development. This study enrolled a total of 169 CI patients admitted to the Second Hospital of Hebei Medical University between May 2011 and November 2014. During the same period, a group of 145 individuals were recruited at the same hospital as healthy controls after thorough physical examination. Serum IL-10 levels were measured by enzyme-linked immunosorbent assay (ELISA). SPSS 19.0 (IBM, 2010, Chicago, IL, USA) and Comprehensive Meta-Analysis 2.0 (CMA 2.0) software were used for data analysis. Serum levels of IL-10 (pg/mL) were significantly lower in CI patients when compared to healthy controls (15.36 ± 3.21 vs. 21.64 ± 5.17, t = 13.12, P IL-10 (pg/mL) compared to healthy controls (LAAS 14.77 ± 5.21, CEI 15.25 ± 5.10, LAC 16.58 ± 4.92, all P IL-10 levels when pair-wise comparisons were made between these three clinical subtypes of CI (all P > 0.05). Logistic regression analysis indicated that, with the exception of triglyceride (TG) and uric acid (UA) levels (both P > 0.05), the other seven parameters, including fasting blood glucose (FPG), total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), creatinine (Cr), systolic blood pressure (SBP), and diastolic blood pressure (DBP), strongly correlated with CI development (all P IL-10 levels and CI (SMD = 1.797, 95% CI 0.785~2.810, P = 0.001). Subgroup analysis based on country showed that low serum levels of IL-10 may be the major risk factor for CI in Croatia (SMD = 2.961, 95% CI 2.480~3.443, P IL-10 serum levels and CI displayed negative relationship in Asians (SMD = 2.522, 95% CI 0.468~4.576, P = 0.016) but not in Caucasians (P > 0

  14. CT and MRI Imaging Features of Type 2 Diabetes Complicated with Cere-bral Infarction%2型糖尿病并发脑梗塞的CT及MRI影像学特征

    Institute of Scientific and Technical Information of China (English)

    樊会军; 律静; 孟建华

    2015-01-01

    目的 探讨2型糖尿病并发脑梗塞的CT及MRI影像学特征和诊断价值. 方法 回顾性分析117例糖尿病并发脑梗塞患者的CT和MRI影像学资料.结果 2型糖尿病并发脑梗塞在CT及MRI影像学上的特点以多发性腔隙性梗塞为主. 在117例患者中,87例为多发病灶,占75%;在所有病灶中最大直径在2 cm以下的占82%;圆形或卵圆形病灶占65%;基底节、丘脑部位占63%. 结论 2型糖尿病并发脑梗塞的CT及MRI影像学有其特殊的表现,应提高对该病的认识水平以避免误诊或漏诊.%Objective To investigate the imaging features and diagnostic value of CT and MRI in type 2 diabetic patients with cerebral infarction. Methods CT and MRI imaging features of 117 patients with cerebral infarction complicated by cerebral infarction were retrospectively analyzed. Results Type 2 diabetes complicated with cerebral infarction in CT and MRI imaging of multiple lacunar infarction. In 117 patients, 87cases for multiple lesions, accounting for 75%; in all lesions in maximum diameter at below 2 cm accounted for 82%; round or oval lesions accounted for 65%; basal ganglia and thala-mus accounted for 63%. Conclusion Type 2 diabetes with cerebral infarction of CT and MRI imaging has its special perfor-mance, should improve the level of awareness of the disease to avoid misdiagnosis or missed diagnosis.

  15. 脑梗死患者相关危险因素分析%Analysis of related risk factors in patients with cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    李红娟; 李庆

    2013-01-01

    目的:探讨脑梗死患者的相关危险因素.方法:分析180例脑梗死患者及对照组的一般资料,测定两组患者血糖、血尿酸和血脂浓度,其中血脂包括:血清总胆固醇(TC)、甘油三酯(TG)、脂蛋白(a)[LP(a)]、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B100(ApoB100).结果:脑梗死组与对照组比较,年龄、性别没有差异,脑梗死组体重、家族史、吸烟史、饮酒史、糖尿病史、高血压史均高于对照组(P<0.05);脑梗死组与对照组各项临床生化指标比较,脑梗死组TC、TG、LP(a)、LDL-C、Glu及UA水平明显升高(P<0.01),HDL-C、Apo A1水平明显降低(P<0.05),Apo B100水平降低但差别无统计学意义.结论:高血压、高血糖、烟酒嗜好、高尿酸和高血脂是引起脑梗死的危险因素,定期测定脑梗死患者的血压、GLU、UA及血脂有助于判断病情及预后.%Objective: To explore the related risk factors in patients with cerebral infarction. Methods: One hundred and eighty cases with cerebral infarction and 180 controls were collected to determine blood glucose, serum uric acid and lipid concentrations, including serum total cholesterol (TC), triglyceride (TG), lipoprotein (a) [ Lp (a) ], low - density lipoprotein cholesterol (LDL - C), high density lipoprotein cholesterol (HDL - C), apoli-poprotein A1 (Apo A1), apolipoprotein B100 (Apo B100). Results: Compared to control group, there was no difference in age and gender. But weights, family history, smoking history, drinking history, diabetes history and hypertension history of cerebral infarction group were higher than control group (P <0.05); Compared to control group about the clinical and biochemical indicators, TC, TG, Lp(a), LDL - C, Glu and UA levels of cerebral infarction group significantly increased (P <0.01), while HDL - C and Apo Al levels were significantly lower (P < 0.05), Apo B100 level decreased, but the

  16. The effect of butylphthalide on the brain edema, blood-brain barrier of rats after focal cerebral infarction and the expression of Rho A.

    Science.gov (United States)

    Hu, Jinyang; Wen, Qingping; Wu, Yue; Li, Baozhu; Gao, Peng

    2014-06-01

    The aim of this study was to explore the effect of butylphthalide on the brain edema, blood-brain barrier of rats of rats after focal cerebral infarction and the expression of Rho A. A total of 195 sprague-dawley male rats were randomly divided into control group, model group, and butylphthalide group (40 mg/kg, once a day, by gavage). The model was made by photochemical method. After surgery 3, 12, 24, 72, and 144 h, brain water content was done to see the effect of butylphthalide for the cerebral edema. Evans blue extravasation method was done to see the changes in blood-brain barrier immunohistochemistry, and Western blot was done to see the expression of Rho A around the infarction. Compared with the control group, the brain water content of model group and butylphthalide group rats was increased, the permeability of blood-brain barrier of model group and butylphthalide group rats was increased, and the Rho A protein of model group and butylphthalide group rats was increased. Compared with the model group, the brain water content of butylphthalide group rats was induced (73.67 ± 0.67 vs 74.14 ± 0.46; 74.89 ± 0.57 vs 75.61 ± 0.52; 77.49 ± 0.34 vs 79.33 ± 0.49; 76.31 ± 0.56 vs 78.01 ± 0.48; 72.36 ± 0.44 vs 73.12 ± 0.73; P edema, protect the blood-brain barrier, and decrease the expression of Rho A around the infarction.

  17. Gamma-Hydroxybutyrate (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (1,4-BD) reduce the volume of cerebral infarction in rodent transient middle cerebral artery occlusion.

    Science.gov (United States)

    Sadasivan, Shankar; Maher, Timothy J; Quang, Lawrence S

    2006-08-01

    gamma-Hydroxybutyric acid (GHB), an endogenous organic acid catabolite of gamma-aminobutyric acid (GABA), has been shown to have tissue-protective effects in various organs, including the brain. We examined the potential neuroprotective effect of GHB and its chemical precursors, gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD), in the rodent ischemic stroke model by intraluminal filament middle cerebral artery occlusion (MCAO). Adult male Sprague-Dawley rats underwent transient left-sided MCAO and received intraperitoneal treatment with 300 mg/kg of GHB, GBL, 1,4-BD, or control vehicle given at 30 min before, as well as 180 and 360 min after the onset of ischemia. Infarct volumes were determined 24 h after MCAO. In transient MCAO, the mean volume of infarction for control rats was 464.4 +/- 17.9 cu.mm versus 273.6 +/- 53.1, 233.3 +/- 44.7, and 275.4 +/- 39.9 cu.mm for rats treated with 1,4-BD (P GBL (P GBL, and 1,4-BD protect against rat focal cerebral ischemia from transient MCAO.

  18. Brain-derived neurotrophic factors increase the proliferation and differentiation of endogenous neural stem cells in mouse models of cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Dawei Zang; Juan Liu; Xianhua Zuo; Surindar Cheema

    2007-01-01

    BACKGROUND: It has been confirmed that brain-derived neurotrophic factor (BDNF) can promote the proliferation of neural stem cells (NSCs) and protect neuron-like cells in vitro. However, its effect on endogenous NSCs in vivo is still unclear.OBJECTIVE: To evaluate whether BDNF can induce the endogenous NSCs to proliferate and differentiate into the neurons in the mice model of cerebral infarction.DESIGN: A synchronal controlled observation.SETTINGS: Department of Neurology, Microbiology Division of the Department of Laboratory, Tianjin First Central Hospital; Howard Florey Institute, Medical College, the University of Melbourne.MATERIALS: Twenty-four pure breed C57BL/6J mice at the age of 10 weeks old (12 males and 12 females)were divided into saline control group and BDNF-treated group, 6 males and 6 females in each group.METHODS: The experiments were performed at the University of Melbourne from July 2004 to February 2005. ① The left middle cerebral artery (MCA) was ligated in both groups to establish models of cerebral infarction and the Matsushita measuring method was used to monitor the blood flow of the lesioned region supplied by MCA. 75% reduction of blood flow should be reached in the lesioned region. ② At 24 hours after infarction, mice in the BDNF-treated group were administrated with BDNF, which was slowly delivered using an ALZET osmium pump design. BDNF was dissolved in saline at the dosage of 500 mg/kg and injected into the pump, which could release the solution consistently in the following 28 days. The mice in the saline control group accepted the same volume of saline at 24 hours after infarction. ③ The Rotarod function test began at 1 week preoperatively, the time stayed on Rotarod was recorded. The mice were tested once a day till the end of the experiment. At 4 weeks post cerebral infarction, double labeling of Nestin and GFAP, BⅢ tubulin and CNPase immunostaining was performed to observe the differentiation directions of the re

  19. Early Rehabilitation of Acute Stroke Patients with Hemiplegia and Effects of regional Cerebral Blood Flow (rCBF) of the Patients with Cerebral Infarction by Early Rehabiiitation

    Institute of Scientific and Technical Information of China (English)

    Luo ZuMing; Xiong Hai

    2000-01-01

    Objectives: To investigate whether early rchabilitation could improve obviously clinical prognosis of acute stroke patients. The mechanism of early rehabilitation that could improve brain function was preliminarily studied. Methods: 240 patients with acute hemiplegia were randomly divided into control group (120 cases) and rehabilitation group (120 cases). The control group received general treatment and the latter received early rehabilitation (Bobath methods) besides general treatment. At pre-rehabilitation and the end of 1,2,3,4,5,6 month at post-rehabilitation, the neurological deficit was assessed with modified Edinbcrg-Scandinavian stroke scale (MESSS); the motor function of the hemiplegic limbs were assessed with modified Fugl-meyer motor scale (FM);the ADL were assessed with modified Barthel Index (MBI), and the general secondary complications of both groups were also evaluated. Moreover, rCBF of 72 cases of acute cerebral infarction with hemiplegia (34 in control group, 38 in rehabilitation group) was earned out by SPECT imaging at pre-rehabilitation and at the end of I month at post - rehabilitation.Results and Discussion: Compared with those of control group, at the end of 1,2,3,4,5,6 month at post - rehabilitation, the scores of MESSS were more obviously decreased (p<0.05 and p<0.01); the scores of MBI and FM were more significantly increased (p<0.05 and p<0.01); and morbidity of secondary complications was more significantly decreased (p<0.05 and p<0.01). Compared with those of pre-rehabilitation in rehabilitation group, both the decrease of MESS scores and the increase of FM, MBI scores were more obvious (p<0.01) at the end of 1,2,3 month of post-rehabilitation; however, compared with that of the end of 3 month at post-rehabilitation, at the end of 4,5,6 month of post-rehabilitation in rehabilitation group. Both the decrease of MESSS scores and the increase of FM scores hadn′t statistical significance (p>0.05). but scores of MBt were

  20. Infarto cerebral hemorrágico por embolización de un trombo mural cardíaco Hemorrhagic cerebral infarction due to embolization of a mural thrombus within the right ventricle

    Directory of Open Access Journals (Sweden)

    R. Marín

    2008-04-01

    Full Text Available Las enfermedades cerebrovasculares son consecuencia de una alteración en la circulación cerebral. Su forma más distintiva de presentación es el ictus, entendido como un déficit neurológico focal de instauración brusca y evolución rápida. Un infarto cerebral de origen oclusivo puede deberse bien a una trombosis in situ o bien a una embolia procedente de un foco distante. En las embolias cerebrales la causa principal son los trombos murales cardiacos y el área encefálica afectada con mayor frecuencia es el territorio irrigado por la arteria cerebral media. Presentamos el caso de una mujer de 81 años, con antecedentes de Hepatitis C, cardiopatía hipertensiva y fibrilación auricular crónica, que sufrió una fractura de cadera consecutiva a una caída accidental. Durante el ingreso hospitalario comenzó un cuadro de deterioro neurológico progresivo que no llegó a ser filiado, falleciendo 9 días después. En la autopsia médico-forense se encontró un infarto cerebral hemorrágico en el territorio de la arteria cerebral media izquierda. Dado que las arterias del Polígono de Willis eran permeables y ante la presencia de trombos vitales adheridos a la pared del ventrículo derecho, se estimó como causa más probable del accidente vasculocerebral la embolización de uno de dichos trombos.Cerebrovascular diseases are due to a disturbance in cerebral blood flow. The most frequent way of presentation is stroke, defined as a sudden and focal neurological impairment with rapid evolution. Cerebral infarction of occlusive origin can be secondary to in situ thrombosis or to embolism from a distal focus. Mural thrombi are the main cause of brain embolism and the middle cerebral artery territory is the most likely affected brain area. We report the case of an 81 year-old woman, with antecedents of Hepatitis C, hypertensive cardiopathy and chronic atrial fibrillation, who suffered a hip fracture due to an accidental fall. A progressive

  1. Analysis of cranial nerve growthine improving quality of life in cerebral infarction%脑神经生长素治疗脑梗死患者生存质量分析

    Institute of Scientific and Technical Information of China (English)

    吴建农; 刘建新

    2002-01-01

    Background: Cranial nerve growthine (CNG) is a kind of new biochemical drug containing many special neuroactive substances which have a good therapeutic effect in cerebrovascular diseases, and can distinctly improve quality of life for patients with cerebral infarction. The quality of life is an improtant factor for rehabilitation,it is life satisfaction, psychological well being,happiness,adaptation and mental health.

  2. Relationship between the -455G/A and -148C/T polymorphisms in the beta-fibrinogen gene and cerebral infarction in the Xinjiang Uygur and Han Chinese populations

    Institute of Scientific and Technical Information of China (English)

    Xiaoning Zhang; Yanyun Li; Xuebing Guo; Lei Du; Jianhua Ma

    2012-01-01

    We sought to investigate the correlation between the -455G/A and -148C/T polymorphisms of the β-fibrinogen gene and plasma fibrinogen levels in patients with cerebral infarction and in healthy subjects among the Xinjiang Uygur and Han Chinese populations, by using polymerase chain reaction-restriction enzyme digestion analysis.Results showed that there were no statistically significant differences in the distributions of the -455G/A genotype and allele frequency between the Uygurs and the Han.Plasma fibrinogen levels in cerebral infarction patients among the Uygurs and the Han were higher than those among healthy subjects.In particular, the frequencies of the -455G/A AA and -148C/T TT genotypes were significantly higher than in healthy subjects.Individuals carrying the A or T allele had a higher incidence of cerebral infarction compared with those carrying the G or C allele.Our experimental findings indicate that the -148C/T and -455G/A polymorphisms are associated with cerebral infarction in Xinjiang Uygur and Han Chinese subjects.The susceptibility- conferring alleles are -148T and -455A, and the susceptibility-conferring genotype is -455G/A + AA.

  3. Investigation on risk factors of post-cerebral infarction depression%脑梗死后抑郁发生的危险因素调查研究

    Institute of Scientific and Technical Information of China (English)

    邱洪兵; 张松林; 潘癸彬; 袁学进; 吕胜来

    2016-01-01

    Objective This article aims to investigate the incidence and relative risk factors of post-cere-bral infarction depression (PCID),in order to provide theoretical evidences for psychological intervention of cerebral infarction. Methods A total of 220 patients with cerebral infarction,who were hospitalized at our hospital from June 2013 to February 201 6,were tested by using Hamilton Depression Scale (HAMD).The baseline data of the patients were collected for analyzing the incidence and risk factors of PCID. Results A-mong 220 cerebral infarction cases,109 cases of them suffered with PCID.The total incidence of PCID was 49.54%,including 92 cases with mild depression (84.40%),15 cases with moderate depression (13.76%)and 2 cases with serious depression (1.83%).Results of stepwise Logistic regression analysis showed the inde-pendent risk factors included females (OR =1.80,95% CI :1.25~2.64),hospitalization over a month (OR=2.41,95% CI :1.60 ~5.96),non-first attack of cerebral infarction (OR =3.72,95% CI :1.31 ~8.59), and moderate severe NIHSS (OR =2.83,95% CI :1.32 ~4.74). Conclusion The incidence of PCID was relatively high,which could be intervened by regulating risk factors.%目的:了解脑梗死后抑郁症(PCID)的发生率及相关因素,为脑梗死患者的心理干预提供理论依据。方法采用汉密尔顿抑郁量表(HAMD)对我院2013年6月~2016年2月220名脑梗死患者进行评分测定,使用调查表收集患者情况,统计分析抑郁症的发生率及影响因素。结果220例脑梗死患者发生 PCID 109例(49.55)%,其中轻度抑郁92例(84.40%),中度抑郁15例(13.76%),重度抑郁2例(1.83%)。二元 Logistic 逐步回归分析结果:性别为女性(OR =1.80,95% CI :1.25~2.64)、住院时间大于1个月(OR =2.41,95% CI :1.60~5.96)、非首次脑梗死(OR =3.72,95% CI :1.31~8.59)及 NIHSS 中重度(OR =2.83,95% CI :1.32~4.74)为 PCID 发生的独立危险因素。结论脑梗死后抑郁发病率较高,可通过调控危险因素予以干预。

  4. Acute Cerebral Infarction by Venomous Snake Bite in CT and MRI%少见毒蛇咬伤致急性脑梗死的CT和MRI表现

    Institute of Scientific and Technical Information of China (English)

    李秀涛; 王立振; 胡元明

    2015-01-01

    Objective To determine the CT and MRI ifndings of acute cerebral infarction by venomous snake bitten.Methods The imaging ifndings of 7 patients with acute cerebral infarction by venomous snake bitten were analyzed retrospectively with literatures review.Results 2 case was bitten by Pit viper. 4cases were bitten by Russell's viper and 1 case was unknown viper. One leaf or multiple leaves cerebrum occurred frequently. Acute obstruct with multiple mottling, patchy, or schistose. 84 acute cerebral infarction in 21 leaves cerebrum of 7 cases, parietal lobe(26/84,30.95%),frontal lobe(19/84,22.62%),occipital lobe(21/84,25%),temporal lobe(16/84,19.05%),basal ganglia(2/84,2.38%), Infarct with hemorrhages in 1 case.Conclusion Combination with the history of venomous snake bitten, the acute cerebral infarction could be diagnosed by CT and MRI, which had great value in the clinical treatment planning for identifying the intracal hemorrhage.%目的:探讨毒蛇咬伤致急性脑梗死的CT和MRI表现特征。方法对7例毒蛇咬伤致急性脑梗死的影像学表现结合文献进行回顾性分析。结果7例患者,2例五步蛇咬伤,4例蝰蛇咬伤,1例不明毒蛇咬伤。大脑一叶或多叶脑组织内多发散在分布的斑点状、斑片状、片状急性脑梗死。7例共21个脑叶84个急性脑梗死病灶,其中顶叶7个26个病灶(26/84,30.95%)、额叶6个19个病灶(19/84,22.62%)、枕叶4个21个病灶(21/84,25%)、颞叶3个16个病灶(16/84,19.05%)、基底节1个2个病灶(2/84,2.38%),1例合并脑内出血。结论结合毒蛇咬伤史,CT和MRI检查对毒蛇咬伤致急性脑梗死可明确诊断,并明确有无出血,对临床治疗方案提供有价值的信息。

  5. 亚临床甲减对脑梗死患者颈动脉粥样硬化程度的影响%Analysis of the impact of subclinical hypothyroidism on carotid atherosclerosis degree of patients with cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    李滨; 吴琳; 李连波; 李栋; 冯爱萍; 冯磊

    2014-01-01

    目的:探讨亚临床甲减对脑梗死患者颈动脉粥样硬化程度的影响。方法选取2011-2012年在我院诊治的26例单纯亚临床甲减患者(甲减组),25例单纯脑梗死患者(脑梗死组),22例亚临床甲减合并脑梗死患者(甲减合并脑梗死组),以及23例健康体检者(对照组),共96例作为研究对象。检测对所有患者的血脂水平、超敏C反应蛋白(CRP)含量、颈动脉内膜中层厚度(IM T ),并对各组进行比较分析。结果甲减合并脑梗组的hs-CRP、TC、LDL-C、IM T明显高于对照组、甲减组及脑梗组(P<0.05),差异具有统计学意义。结论脑梗死合并亚临床甲减可加重动脉粥样硬化程度,临床干预脑梗死合并亚临床甲减非常必要。%Objective To analyze the influence of subclinical hypothyroidism on carotid atherosclerosis of patients with cer-ebral infarction.Methods Ninety-six cases admitted in our hospital during 2011-2012 were chosen as the research subjects ,in-cluding 26 patients with simple subclinical hypothyroidism (hypothyroidism group) ,25 patients of simple cerebral infarction ,22 cases of subclinical hypothyroidism combined with cerebral infarction (hypothyroidism merged with cerebral infarction group) , and 23 cases healthy check-up(control group).The blood lipid levels ,hypersensitive c-reactive protein (hs-CRP) levels ,carotid intima-media thickness (IMT) in all patients were detected and analyzed comparatively.Results The hs-CRP ,TC ,LDL-C and IMT of hypothyroidism combined with cerebral infarction group were significantly higher than those of the control group ,hy-pothyroidism group and cerebral infarction group (P<0.05) ,the difference had a statistical significance.Conclusion Cerebral infarction combined with subclinical hypothyroidism can aggravate atherosclerosis ,clinical intervention in these patients is very necessary.

  6. 脑梗死患者并发骨质疏松的相关危险因素及预防对策%The Related Risk Factors and the Preventive Measures of Cerebral Infarction Patients Complicated with Osteoporosis

    Institute of Scientific and Technical Information of China (English)

    陈炜; 张之福

    2015-01-01

    Objective To explore the related risk factors and the preventive measures of cerebral infarction patients complicated with osteoporosis. Methods 166 cases of cerebral infarction patients complicated with osteoporosis in our hospital from June 2012 to June 2014 were selected. Results Women with cerebral infarction in patients with the incidence of osteoporosis was significantly higher than that in male patients,the dif erence was statistical y significant ( < 0.05).The related risk factors and the preventive measures of cerebral infarction patients complicated with osteoporosis were cerebral infarction disease,severity,elderly,women,low body mass index,smoking,hypertension.Conclusion The related risk factors and the preventive measures of cerebral infarction patients complicated with osteoporosis are cerebral infarction disease,severity,elderly,women,low body mass index,smoking, hypertension,it should be pay at ention to the positive targete prevention.%目的:探讨脑梗死患者并发骨质疏松的相关危险因素及预防对策。方法从本院2012年6月~2014年6月收治的脑梗死患者中随机选择166例进行研究。结果女性脑梗死患者的骨质疏松发生率显著高于男性患者,差异有统计学意义(<0.05)。骨质疏松相关危险因素有脑梗死病程、病情程度、高龄、女性、低体重指数、高血压病、抽烟。结论脑梗死患者并发骨质疏松的相关危险因素有脑梗死病程、病情程度、高龄、女性、低体重指数、高血压病、吸烟,临床要注意积极的予以针对性预防。

  7. 肺心病合并脑梗死患者血液流变及血气分析%Blood Rheology and Blood Gas Analysis Effect in Patients with Cor Pulmonale Combination Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    米娜瓦尔·艾麦提

    2013-01-01

    目的:探讨肺心病合并脑梗死患者的血液流变和动脉血气的改变。方法:选取近期来本院就诊的肺心病患者58例,脑梗死患者62例,肺心病合并脑梗死患者48例,同时,另选50例健康老年人作为健康对照组。对所有患者进行全血粘度、血浆粘度、血沉、红细胞压积和纤维蛋白原检测,并计算红细胞聚集指数等血流变指标。测定氧分压、二氧化碳分压、第一秒用力呼气容积等肺功能指标,比较各组患者各指标的差异。结果:肺心病合并脑梗死组患者血流变各指标明显高于对照组、脑梗死组和肺心病组(P<0.01);肺心病合并脑梗死组患者的PaO2、FEV1明显低于对照组、脑梗死组和肺心病组(P<0.01),而肺心病合并脑梗死组患者的PaCO2均高于其他三组(P<0.01)。结论:肺心病和脑梗死对正常血液流变及肺功能的损害存在交互作用,血液流变和动脉血气检测对肺心病合并脑梗死的诊断及治疗有一定的指导意义。%Objective:To study arterial blood gas and blood rheology in patients with cor pulmonale combination cerebral infarction.Method:58 patients who suffered Cor Pulmonale,62 patients who suffered cerebral infarction and 48 patients with cor pulmonale combination cerebral infarction were selected.50 healthy old people were selected as a healthy control group at the same time.For all patients with whole blood viscosity,plasma viscosity,blood sedimentation,red blood cells deposited and fibrinogen detection,indexes such as red blood cell aggregation index were all calculated. Determination of oxygen partial pressure,CO2 partial pressure,the first second forced expiratory volume,which were the indices of pulmonary function to compare the difference between the groups of patients with various indicators.Result:The indexes of blood rheology in cor pulmonale combination cerebral infarction patients group was obviously higher than

  8. 磁共振扩散张量成像在急性缺血性脑梗死时相判断中的应用%Application of diffusion tensor imaging in judging infarction time of acute ischemic cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    戴真煜; 陈飞; 姚立正; 董从松; 刘洋; 侍海存; 张志平; 杨乃忠; 张明生

    2015-01-01

    Objective To evaluate the clinical application value of diffusion tensor imaging (DTI) and diffusion tensor tractography (DTF) in judging infarction time phase of acute ischemic cerebral infarction.Methods To retrospective analysis DTI images of 52 patients with unilateral acute ischemic cerebral infarction (hyper-acute,acute and sub-acute) from the Affiliated Yancheng Hospital of Southeast University Medical College,which diagnosed by clinic and magnetic resonance imaging.Set the regions of interest (ROIs) of infarction lesions,brain tissue close to infarction lesions and corresponding contra (contralateral normal brain tissue) on DTI parameters mapping of fractional anisotropy (FA),volume ratio anisotropy (VRA),average diffusion coefficient (DCavg) and exponential attenuation (Exat),record the parameters values of ROIs and calculate the relative parameters value of infarction lesion to contra.Meanwhile,reconstruct the DTI images based on the seed points (infarction lesion and contra).The study compared each parameter value of infarction lesions,brain tissue close to infarction lesions and corresponding contra,also analysed the differences of relative parameters values in different infarction time phases.Results The DTT images of acute ischemic cerebral infarction in each time phase could show the manifestation of fasciculi damaged.The DCavg value of cerebral infarction lesions was lower and the Exat value was higher than contra in each infarction time phase (P < 0.05).The FA and VRA value of cerebral infarction lesions were reduced than contra only in acute and sub-acute infarction (P < 0.05).The FA,VRA and Exat value of brain tissue close to infarction lesions were increased and DCavg value was decreased than contra in hyper-acute infarction (P < 0.05).There were no statistic differences of FA,VRA,DCavg and Exat value of brain tissue close to infarction lesions in acute and sub-acute infarction.The relative FA and VRA value of infarction lesion to contra

  9. Ser um miR-126 and miR-146a levels in patients with acute cerebral infarction and their relationship with sever ity of the disease

    Directory of Open Access Journals (Sweden)

    Xiao-Yan Zhu

    2016-09-01

    Full Text Available Objective: To analyze the serum levels of miR-126, miR-146a and its relationship with infarction area, severity of disease and inflammatory reaction degree in patients with acute cerebral infarction (ACI. Methods: A total of 75 cases with ACI treated in our hospital from April 2014 to October 2015 and 80 healthy cases were respectively selected as ACI group and control group for retrospective study. Patients' clinical data were collected, and the serum levels of miR-126, miR-146a, tumor necrosis factor-a (TNF-a, interleukin-1b (IL-1b and IL-6 were detected. Results: Serum contents of miR-126 (0.286 ± 0.078 vs. 1.000 ± 0.169 and miR-146a (0.337 ± 0.084 vs. 1.000 ± 0.158 in patients of ACI group were significantly lower than those of control group. Contents of IL-1b [(68.4 ± 10.3 vs. (22.7 ± 5.8 ng/L], TNFa [(126.9 ± 22.4 vs. (49.6 ± 8.4 ng/L] and IL-6 [(89.3 ± 14.7 vs. (34.8 ± 5.9 ng/L] were obviously higher than those of control group. The bigger the infarction area was, the more severer the degree of nerve defect could be. The lower the serum levels of miR-126, miR-146a were, the higher the levels of TNF-a, IL-1b, IL-6 could be. Levels of miR-126 and miR-146a were negative correlation with levels of TNF-a, IL-1b and IL-6. Conclusions: An abnormal decrease in serum levels of miR-126 and miR-146a in patients with ACI was closely related to the severity of disease. Through regulating the generation of inflammatory factors TNF-a, IL-1b and IL-6, miR-126 and miR-146a may get involved in the changes of cerebral infarction condition.

  10. Family empowerment model in cerebral infarction patients%家属赋能模式在脑梗塞病人中的应用

    Institute of Scientific and Technical Information of China (English)

    李芳

    2013-01-01

    Objective: To investigate the family empowerment model in cerebral infarction patients and their families in the application. Methods: 80 cases of cerebral infarction were randomly divided into the observation group and the control group with 40 cases in each group, the control group used the traditional methods of health education; used in the observed group family empowerment mode to carry out health education. Comparison of two groups of patients and their families to the disease knowledge and skils to master degree, degree of satisfaction to the nursing work and the postoperative complications. Results: the patients in the observation group and family health education knowledge and the degree of the satisfaction to the nursing work is higher than that of control group; nursing complication than that of control group (P<0.05). Conclusion: the application of family empowerment on cerebral infarction patients for health education, can significantly improve the patient's self awareness of rehabilitation and family members of patients with the patient's cognitive nursing care; nursing work satisfaction, reduce the occurrence of complications.%  目的:探讨家属赋能模式在脑梗塞患者及其家属中的应用效果.方法:将80例脑梗塞患者随机分为观察组和对照组各40例,对照组采用传统方法进行健康教育;观察组应用家属赋能模式实施健康教育.比较两组患者及家属对疾病认知及技能掌握度、对护理工作的满意度及并发症发生情况.结果:观察组患者及家属对健康教育知识的掌握度和对护理工作的满意度高于对照组;护理并发症少于对照组(P<0.05).结论:应用家属赋能模式对脑梗塞患者进行健康教育,可显著提高患者的自我康复意识及患者家属对病人的认知照护能力;提高护理工作的满意度,减少并发症发生.

  11. 臭氧治疗脑梗死合并高脂血症的疗效观察%Effect of ozone on cerebral infarction with hyperlipidemia

    Institute of Scientific and Technical Information of China (English)

    张卫霞; 朱润秀

    2015-01-01

    Objective: To study the therapeutic effect of ozone in the treatment of cerebral infarction with hyperlipidemia. Methods: 80 patients with cerebral infarction complicated with hyperlipidemia were randomly divided into the experimental group and the control group. The experimental group was treated with ozone blood therapy plus conventional treatment.Results: After treatment, the total effective rate of the experimental group was 92.5%, the total effective rate was 72.5 in the control group, the treatment effect of the experimental group was significantly better than the control group (P<0.05), the difference was statistically significant.Conclusion: The use of ozone in the treatment of cerebral infarction with hyperlipidemia can effectively improve the treatment effect, should be popularized in clinical treatment.%目的:研究臭氧治疗脑梗死合并高脂血症的治疗效果。方法选取80例脑梗死合并高脂血症的患者,将其随机的分为实验组与对照组,实验组采用臭氧自血疗法+常规治疗方法进行治疗,对照组使用中、西医介个内科基础治疗+针灸康复治疗。结果一段时间治疗后,实验组治疗的总有效率为92.5%,对照组的治疗总有效率为72.5,实验组患者的治疗效果明显的优于对照组,(P<0.05)差异具有统计学意义。结论使用臭氧治疗脑梗死合并高脂血症能够有效的提高治疗效果,应在临床治疗中推广应用。

  12. Clinical Characteristics of Restless Legs Syndrome after Acute Cerebral Infarction%急性脑梗死后不宁腿综合征的临床特征

    Institute of Scientific and Technical Information of China (English)

    丁晓; 邓丽影

    2015-01-01

    Objective To investigate the clinical characteristics and inlfuences of restless legs syndrome (RLS) after acute cerebral infarction. Methods All acute cerebral infarction patients admitted were screened in accordance with the deifnition criteria of International Restless Legs Syndrome Study Group (IRLSSG). The patients without RLS were matched with a group in similar with age, gender, location of lesion to RLS group. The clinical characteristics of the patients with and without RLS were analyzed. Results Two hundred and seventy-five patients with acute cerebral infarction were studied. Nineteen cases met the diagnostic criteria for RLS. The morbidity rate is 6.91%. The age of RLS group and non-RLS group were (62.89±10.26)vs (62.63±9.96) respectively. The Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) of RLS group were higher than non-RLS group. Barthel Index (BI) of RLS group was lower than that in non-RLS group (all P10分的比例更高(57.9%vs 21.1%,P=0.020),匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)>15分的比例也更高(47.4%vs 15.8%,P=0.040)。脑梗死后90 d和180 d,RLS组Barthel指数(Barthel Index,BI)低于非RLS组(P值分别是<0.001和<0.001),改良Rankin量表(modified Rankin Scale,mRS)评分高于非RLS组(P值分别是0.64和0.04)。RLS组14例(73.68%)患者合并周期性腿动,15例(78.9%)患者合并阻塞性睡眠呼吸障碍。结论急性脑梗死后RLS患者较无RLS患者睡眠质量及预后更差。

  13. Changes in serum cellular adhesion molecule and matrix metalloproteinase-9 levels in patients with cerebral infarction following hyperbaric oxygen therapy A case and intergroup control study

    Institute of Scientific and Technical Information of China (English)

    Renliang Zhao; Chunxia Wang; Yongjun Wang

    2008-01-01

    BACKGROUND: Animal studies have confirmed that hyperbaric oxygen (HBO) therapy can reduce matrix metalloproteinase activity and blood brain barrier permeability, thereby exhibiting neuroprotective effects. However, at present, consensus does not exist in terms of its clinical efficacy. OBJECTIVE: To validate the significance of changes in serum cellular adhesion molecule and MMP-9 levels in patients with cerebral infarction following HBO therapy. DESIGN, TIME AND SETTING: This randomized, controlled, neurobiochemical study was performed at the Department of Neurology, Affiliated Hospital of Qingdao University Medical College between December 2002 and March 2006. PARTICIPANTS: A total of 112 patients with acute cerebral infarction of internal carotid artery, comprising 64 males and 48 females, averaging (67 ± 11) years, were recruited and randomized to a HBO group (n = 50) and a routine treatment group (n = 62). An additional 30 gender- and age-matched normal subjects, consisting of 17 males and 13 females, averaging (63 ± 9) years, were enrolled as control subjects. METHODS: The routine treatment group received routine drug treatment and rehabilitation exercise. HBO treatment was additionally performed in the HBO group, once a day, for a total of 10 days. MAIN OUTCOME MEASURES: Serum levels of soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, soluble E-selectin, and matrix metalloproteinase-9 were detected by enzyme linked immunosorbent assay. RESULTS: Upon admission, serum levels of soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, soluble E-selectin, and matrix metalloproteinase-9 were significantly increased in patients with cerebral infarction, compared with control subjects (P < 0.01). Following HBO and routine treatments, serum levels of the above-mentioned indices were significantly reduced in the HBO and routine treatment groups (P < 0.01). Moreover, greater efficacy was observed in the HBO

  14. Investigation of Drug use in 166 Patients with Cerebral Infarction%166例脑梗塞住院患者用药情况分析

    Institute of Scientific and Technical Information of China (English)

    丁继岩

    2015-01-01

    Objective The use of drugs in patients with cerebral infarction was investigated, so as to provide guidance for the rational use of drugs. Methods The clinical data of 166 cases of hospitalized patients with cerebral infarction were ret-rospectively analyzed and statistics, in order to understand the patient's clinical use. Results During hospitalization, patients take basic symptomatic treatment and comprehensive treatment methods, the use of drugs dehydration drugs, optimization cerebrovascular circulation drugs, thrombolytic drugs, anti-platelet drugs and anticoagulants, improve brain metabolism, im-prove awareness and nootropic drugs; 140 cases were cured, improved and was discharged 13 cases, 2 cases were trans-ferred, but the hospital did not cure those four cases, 7 deaths. Conclusion To ensure that the effect of the treatment of dis-eases of cerebral infarction, clinicians need to achieve rational use of drugs, medication safety, reduce the incidence of ad-verse reactions.%目的 对脑梗塞住院病人的用药情况展开调查,以便为此病的合理用药提供指导意见.方法 对166例脑梗塞住院患者的临床资料进行回顾性分析,以了解患者的临床用药情况. 结果 在住院治疗期间,患者采取基础对症治疗与综合治疗的方法,所用药物有脱水药物、优化脑血管循环药物、溶栓药物、抗血小板聚集药物与抗凝药物、改善脑代谢、改善意识和促智药物等;140例治愈,好转且出院者13例,转院者2例,并未治愈但出院者4例,7例死亡. 结论为确保脑梗塞疾病治疗的效果,临床医生需做到合理用药、安全用药,降低不良反应的发生.

  15. Therapy of anti-platelet in acute cerebral infarction with cerebral microbleeds%急性脑梗死伴脑微出血患者的抗血小板治疗

    Institute of Scientific and Technical Information of China (English)

    陈佳; 刘维洲; 潘华; 储照虎

    2012-01-01

    目的 探讨抗血小板聚集治疗对急性脑梗死合并脑微出血(cerebral microbleeds,CMB)患者的临床意义.方法 选择铜陵市人民医院神经内科2011年2~12月收治的急性脑梗死患者107例.入院时均常规行MRI加梯度回波T2加权成像(grandient-echo T2 weighted MRI,GRE)检查.根据是否存在CMB分为有CMB组,无CMB组.记录CMB组的CMB发生例数、CMB病灶部位、数目、记录两组患者腔隙性脑梗死、脑白质疏松等情况,记录两组患者的血压、血脂、血糖、既往卒中病史.107例患者均接受抗血小板聚集治疗.治疗后2周复查MRI加GRE.观察两组患者CMB的总数、部位有无变化,有无梗死后出血转化,并探讨CMB的危险因素.结果 CMB在脑部各个区域均有分布,以基底节区最多;高血压(OR=4.004,95%CI=1.483~10.814,P<0.05)、腔隙性脑梗死(OR=10.727,95%CI =3.646~31.563,P<0.05)是CMB发生的危险因素;高血脂、糖尿病、脑白质疏松、抗血小板聚集治疗与CMB发生无明显相关(OR=0.887,95%CI =0.631~1.248,P>0.05).无CMB组治疗两周后无新发CMB;有CMB组CMB的总数、部位均无明显变化(P>0.05);两组患者均无出血转化的发生.结论 CMB在急性脑梗死患者中有较高的发生率,高血压、腔隙性脑梗死是急性脑梗死发生CMB的危险因素.急性脑梗死合并CMB患者在2周内行抗血小板聚集治疗不增加CMB发生率,不增加出血转化的危险.%Objective To investigate the clinical significance of anti-platelet therapy to acute cerebral infarction' with cerebral microbleeds (CMB). Methods 107 patients with acute cerebral infarction had been admitted in the Neurological Department of Tongling People Hospital from February 2011 to December 2011, all patients had been scanned with MRI and GRE series. According to the existence of CMB,the patients fell into two groups,CMB group and non-CMB group. CMB group was recorded in items: CMB occurrence cases,CMB focus

  16. Denaturing high-performance liquid chromatography to diagnose cerebral autosomal dominant arteriopathy in Chinese patients with subcortical infarcts and leukoencephalopathy

    Institute of Scientific and Technical Information of China (English)

    Xiaomei Tang; Biao Chen

    2008-01-01

    BACKGROUND: Notch3 mutations are the molecular genetic foundation for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Of all currently available detection methods, direct sequencing or restriction enzymes are frequently used, but the cost is relatively high, because the Notch3 gene is composed of many exons and mutational sites are widely distributed. Denaturing high-performance liquid chromatography (DHPLC) exhibits high efficiency and specificity and has been applied to gene detection. To date, there has no report regarding DHPLC in gene detection of large-scale CADASIL families in China. OBJECTIVE: To explore the application and value of DHPLC in the diagnosis of CADASIL by a mutation screening for Notch3 gene in CADASIL probands and their family members. DESIGN, TIME AND SETTING: A comparative observation was performed at the Genetic Diagnosis Laboratory of Institute of Geriatrics, Xuanwu Hospital of Capital Medical University and the Key Laboratory for Neurodegenerative Disease of the Ministry of Education between August 2003 and May 2004. PARTICIPANTS: Fourteen CADASIL patients and their family members, comprising eight males and six females, aged 38-62 years, were included. Their key features included recurrent sub-cortical ischemic events and vascular dementia. In addition, 100 healthy physical examinees were selected as controls, including 52 males and 48 females, aged 56-72 years, who had no neurodegenerative disease or psychosis, and no history or high risk for cerebrovascular disease. METHODS: DNA was extracted from white blood cells. Ten hotspots of the Notch3 gene for sequence variation were first amplified by PCR, and the products were detected using DHPLC. Exons exhibiting a variant in the DHPLC profile underwent another PCR amplification, followed by DNA sequencing to identify the mutation type. In addition, patients with normal DHPLC peak profiles underwent PCR amplification for the remaining

  17. Occipital lobe infarctions are different

    OpenAIRE

    Naess, Halvor; Waje-Andreassen, Ulrikke; Thomassen, Lars

    2007-01-01

    Objectives We hypothesized that occipital lobe infarctions differ from infarctions in other locations as to etiology, risk factors and prognosis among young adults. Methods Location, etiology, risk factors and long-term outcome were evaluated among all young adults 15–49 years suffering from cerebral infarction in Hordaland County, Norway between 1988 and 1997. Results The following variables were more frequent among patients with occipital lobe infarction compared with patients with infarcti...

  18. Risk factors of nosocomial lung infection in cerebral infarction%急性脑梗死后肺部感染危险因素分析

    Institute of Scientific and Technical Information of China (English)

    毛玲群; 闻绍云; 黄睿; 金皎蕾

    2011-01-01

    目的 探讨急性脑梗死患者发生医院肺部感染的相关危险因素.方法 回顾性分析本院2008年1月至2009年12月住院治疗的1126例急性脑梗死患者的临床资料.结果 1126例急性脑梗死患者,发生医院肺部感染126例,感染率11.19%,其中2008年未实行单病种质量控制时感染率为14.34%,2009年实行单病种质量控制后感染率为8.52%,两组间比较差异有统计学意义(P=0.001).高龄、肌力Ⅲ级以下、球麻痹症状、意识障碍、空腹血糖异常、糖尿病病史是医院肺部感染的危险因素,而进行单病种质量控制吞咽困难评估是医院肺部感染的保护因素.多因素Logstic回归分析显示,糖尿病病史及肌力Ⅲ级以下与肺部感染明显相关(P=0.014和P=0.000).结论 糖尿病病史及肌力Ⅲ级以下是急性脑梗死发生医院肺部感染独立危险因素.%Objective To explore the risk factors of nosocomial lung infection in patients with cerebral infarction. Methods The clinical data of 1 126 hospitalized patients with cerebral infarction were analyzed retrospectively from January 2008 to December 2009. Results It was showed that the nosocomial infection rate was 11.19% (126/1 126 cases with cerebral infarction). In 2008 when no quality control of single-disease was implemented, the infection rate was 14. 35% > while in 2009 when the quality control of single-disease was carried out, the rate became 8.25%, the difference between the two groups being significant (P = 0.001). The infection was closely related with factors, such as old age, physical activity (muscle strength grade I or less), bulbar palsy symptoms, disturbance of consciousness, impaired fasting glucose and history of diabetes, whereas dysphagia assessment in quality control of single-disease was a protective factor from infection. Multivariate logistic regression analysis showed that history of diabetes and poor physical activity (muscle strength grade I or less) were correlated

  19. The effect of lipid regulation with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction

    Directory of Open Access Journals (Sweden)

    Shu XU

    2015-11-01

    Full Text Available Objective To analyze the effect of intensive lipid regulation treatment with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction.  Methods Ninety-two patients with atherosclerotic cerebral infarction were randomly divided into two groups: observation group (treated by atorvastatin calcium with the dosage of 20 mg/d, N = 46 and control group (treated by diet without lipid-rich food, N=46. Besides, other drugs given to the patients in two groups were the same. The blood lipid levels and the changes of carotid artery plaques in two groups were analyzed and compared before treatment and 3 months after treatment. Results After treatment, the concentrations of total cholesterol [TC, (4.23 ± 0.92 mmol/L vs (5.24 ± 0.68 mmol/L], triglyceride [TG, (2.46 ± 0.28 mmol/L vs (3.33 ± 0.47 mmol/L], low-density lipoprotein cholesterol [LDL-C, (2.52 ± 0.38 mmol/L vs (4.78 ± 0.86 mmol/L] in the patients of observation group were all decreased and significantly lower than those in the control group (P = 0.000, for all, and the concentration of high-density lipoprotein cholesterol [HDL-C, (1.13 ± 0.41 mmol/L vs (0.85 ± 0.32 mmol/L] in the patients of observation group was increased and significantly than that in the control group (P = 0.003. The carotid artery plaque size [(20.25 ± 0.32 mm2 vs (24.42 ± 10.33 mm2] and thickness [(0.59 ± 0.13 mm vs (1.93 ± 0.23 mm] of carotid artery plaques and intima?media thickness [IMT, (1.32 ± 0.67 mm vs (1.63 ± 0.56 mm] of common carotid artery (CCA in the patients of observation group were all significantly lower than those in patients in the control group (P = 0.000, 0.000, 0.010, respectively. Comparing serum alanine aminotransferase (ALT, aspartate aminotransferase (AST, creatine kinase (CK and creatinine (Cr levels after treatment with before treatment, there was no significant difference between 2 groups (P > 0.05, for all.  Conclusions

  20. 垂体卒中导致脑梗死的系统分析%Cerebral infarction caused by pituitary apoplexy:a systemic analysis

    Institute of Scientific and Technical Information of China (English)

    潘元美; 李焰生

    2013-01-01

      目的通过回顾性分析文献,总结有垂体卒中导致的脑梗死的临床特点以增进对之认识。方法通过检索Pubmed、Medline、维普和万方电子数据库,对1950年~2011年间有关垂体卒中所致脑梗死的病例报道进行分析。结果共纳入英文文献19篇,共计患者21例,临床症状主要为意识障碍(81畅0%)、突发的头痛(76畅2%)、视力障碍(61畅9%)、眼外肌麻痹(52畅4%)和偏瘫(71畅4%)等。52畅4%的患者累及多支血管。机械性压迫和血管痉挛是垂体卒中所致脑梗死的主要机制。16例患者接受了经蝶或经颅手术治疗,接受急诊手术的7例中有4例(57畅1%)患者出现死亡,明显高于择期手术患者(P<0畅05)。结论垂体卒中所致脑梗死临床症状危重,预后较差,急诊手术的死亡风险较大。%Objective To characterize the clinical features of the cerebral infarction caused by pituitary apoplexy by systemic analysis of the literatures. Methods A literature (from 1950 to 2011) rearch about the cerebral infarction caused by pituitary apoplexy were performed using the reference database Pubmed , Medline, and Chinese database (Wei Pu and Wan Fang). Results A total of 19 English published literatures with 21 patients were collected for analysis.The clinical symptoms mainly were disturbance of consciousness (81.0%), sudden headache (76.2%), visual impairment (61.9%), ophthalmoplegia (52.4%), and hemiplegia (71.4%).About 52.4%of patients had multi-vessel involvement.Mechanical pressure and vasospasm were considered as the pathogenesis of cerebral infarction caused by pituitary apoplexy .16 patients had received transsphenoidal or transcranial surgical treatment.Among them, 7 patients had urgent surgery and 4 patients died, which was significantly higher than that of the patients got elective surgery (P<0.05). Conclusion Pituitary apoplexy caused cerebral infarction is a rare but

  1. Clinical study of hypothyroidism with cerebral infarction%甲状腺功能减退合并脑梗死的临床研究

    Institute of Scientific and Technical Information of China (English)

    李瑜霞; 马洪颖; 李永秋; 赵丽丽; 刘春芹

    2014-01-01

    Objective To observe the effect of hypothyroidism and subclinical hypothyroidism on acute cerebral infarction. Methods 84 patients with hypothyroidism or subclinical hypothyroidism combined with acute cerebral infarction were recruited into this study. 88 acute cerebral infarction patients without hypothyroidism or subclinical hypothyroidism on the corresponding period were enrolled as the control group. Thyroid function,the level of blood glucose( GLU),total cholesterol( TC),low density lipoprotein-cholesterol( LDL-C),triglyceride( TG),homo_cysteine(HCY),and fibrinogen(FIB)were tested,and cervical vascular ultrasonic examination was performed. Results Compared with the control group,patients in hypothyroidism group and subclinical hypothyroidism group were significantly higher at the level of blood GLU,HCY, TC,LDL-C and TG. And there are significant difference in the carotid atherosclerotic plaque and carotid artery stenosis among the groups. The incidence of plaque and carotid artery stenosis were higher in hypothyroidism group than that of subclinical hypothyroidism group,and higher than that in subclinical hypothyroidism group,higher than that in control group. Conclusion Hypothyroidism or subclinical hypothyroidism may be one of the risk factors of acute cerebral infarction.%目的:研究甲状腺功能减退(甲减)、亚临床甲减对脑梗死的影响。方法选取甲减合并脑梗死、亚临床甲减合并脑梗死的患者84例,无甲状腺功能异常病史且入院化验甲状腺功能无异常的同期脑梗死患者88例作为对照组。测定脑梗死患者甲状腺功能、血糖、血脂、血同型半胱氨酸和纤维蛋白原并行颈部血管彩色超声检查。结果甲减组和亚临床甲减组在血糖、血同型半胱氨酸、胆固醇、低密度脂蛋白、甘油三酯等方面均高于对照组,差异有统计学意义;在有无颈动脉粥样硬化斑块、有无血管狭窄方面均存在差异;甲减组斑块发

  2. 脑梗死患者认知和记忆障碍特点分析%Characteristics of cognitive and memory disorders in cerebral infarction patients

    Institute of Scientific and Technical Information of China (English)

    杨轶楠; 刘洪雁; 苏玉萍; 张春艳; 徐文玉; 李阔

    2015-01-01

    Objective To evaluate and analyze the characteristics of cognitive and memory disorders in patients suffering cerebral infarction. Methods The scores of overall cognitive function including orientation to time and place, immediate memory, calculation, delayed memory, naming, repeat, understanding, reading, writing, visuospatial function were evaluated by mini-mental state estimate (MMSE) and the scores of memory function including immediate learning and memory , short time delayed recall , long time delay memories were evaluated by WHO/UCLA Auditory Verbal Learning Test. Statistical analysis were done in patients with cerebral infarction and healthy controls. Results The scores of overall cognitive function, memory scores as well as immediate recall , short-delayed recall , long-delayed recall in cerebral infarction patients were much lower than those of healthy controls (P < 0.001). Conclusion The overall cognitive function and memory function declined significantly , also immediate memory and short term memory were remarkable impaired in patients with cerebral infarction, resulting their memory characteristics were similar to patients with Alzheimer′s disease.%目的:评定及分析脑梗死后患者的认知及记忆障碍的特点。方法:应用简易智能状态量表(MMSE)评定73例脑梗死患者总体认知功能,包括时间定向、地点定向、即刻记忆、计算、延迟回忆、命名、复述、听理解、阅读、书写、视空间功能;应用世界卫生组织-加利福尼亚洛杉矶大学听觉词语学习测验(WHO/UCLA Auditory Verbal Learning Test)评定记忆功能,包括即刻学习记忆、短时延迟回忆及长时延迟回忆,将脑梗死患者评分与健康对照组进行统计学分析比较。结果:脑梗死患者总体认知评分及记忆总分、词语即刻学习记忆、短时延迟回忆、长时延迟回忆均显著低于健康对照组,两组之间差异有统计学意义(P <0.001

  3. Research on risk factors of pressure ulcer in patients with cerebral infarction%脑梗死患者压疮危险因素研究

    Institute of Scientific and Technical Information of China (English)

    张雯凌; 刘全生

    2015-01-01

    Objective To understand the status quo of pressure ulcer(PU) in the patients with cerebral infarction and to investigate its influence factors. Methods Total 164 cases of cerebral infarction in our hospital from January to December 2014 were divided into the PU group(25 cases) and none-PU group(139 cases) according to occurrence of PU. The differences in age, sex,body mass index,comorbidities,hospitalization time,plasma albumin level,consciousness disorders,Modified Rankin Scale (MRS) and Barthel index (BI) rating scale were compared between the two groups. The Logistic regression analysis was adopted for analyzing the PU occurrence related factors. Results The hospitalization time,plasma albumin level,consciousness disor-ders, complicating chronic diseases,Braden score and BI score were the risk factors of PU occurrence(P<0.05 or 0.01);the Logis-tic regression analysis showed that complicating chronic diseases,consciousness disorders,BI score and Braden score had signifi-cant influence on the PU occurrence in the patients with cerebral infarction (P<0.05 or 0.01). Conclusion Complicating chronic diseases,consciousness disorders,BI score and Braden score are the risk factors of PU occurrence in the patients with cerebral in-farction and adopting effective countermeasures could reduce the incidence of PU.%目的 了解脑梗死患者压疮的现状,并探讨其影响因素.方法 将2014年1~12月该院收治的164例脑梗死患者分为压疮组25例和无压疮组139例,比较两组患者在年龄、性别、体质量指数、合并疾病、住院时间、清蛋白水平、Braden得分、意识障碍、残障评定量表(MRS)及Barthel指数评定量表(BI)等方面的差异,采用logistic回归分析压疮发生的相关因素.结果 两组住院时间、清蛋白水平、意识障碍、合并慢性疾病、Braden得分、MRS得分和BI得分对脑梗死患者压疮发生有显著影响(P<0.05或0.01);logistic回归分析显示,合并慢性疾病、

  4. Psychological Evaluation of Patients with Silent Cerebral Infarction%无症状性脑梗死患者的心理功能测评

    Institute of Scientific and Technical Information of China (English)

    肖军; 周波; 许飞; 杨友松

    2002-01-01

    Objective: To evaluate psychological functions of patients with silent cerebral infarction (SCI). Methods: MMSE WMS, SDS, Finger-Tapping Test and Test of Sensory-perceptual Dysfunctions in Halstead Reitan Battery Revised in China were administered to 38 SCI patients identified by CT or MRI, and compared with 30 control subjects.Results: Total score of MMSE in SCI patients did not differ significantly from control subjects. MQ and subtests score of WMS in SCI patients were significantly lower. Finger-Tapping Test and sensory-Perceptual Test in SCI patients were also significantly lower. The positive rate and score of SDS in SCI patients were significantly higher. Conclusion: Significant neuropsychological problems of cognition, memory, fine motion, sensory-perception and emotion were found in SCI patients.

  5. [Cerebral infarction and intracranial aneurysm related to the reactivation of varicella zoster virus in a Japanese acquired immunodeficiency syndrome (AIDS) patient].

    Science.gov (United States)

    Yasuda, Chiharu; Okada, Kazumasa; Ohnari, Norihiro; Akamatsu, Naoki; Tsuji, Sadatoshi

    2013-01-01

    A 35-years-old right-handed man admitted to our hospital with a worsening of dysarthria, left facial palsy and left hemiparesis for 2 days. Acquired immunodeficiency syndrome (AIDS) was diagnosed when he was 28 years old. At that time, he also was treated for syphilis. After highly active antiretroviral treatment (HAART) was introduced at the age of 35 years old, serum level of human immunodeficiency virus (HIV) was not detected, but the number of CD4+ T cells was still less than 200/μl. He had no risk factors of atherosclerosis including hypertension, diabetes and hyperlipidemia. He had neither coagulation abnormality nor autoimmune disease. Magnetic resonance imaging (MRI) showed acute ischemic infarction spreading from the right corona radiate to the right internal capsule without contrast enhancement. Stenosis and occlusion of intracranial arteries were not detected by MR angiography. Although argatroban and edaravone were administered, his neurological deficits were worsened to be difficult to walk independently. Cerebrospinal fluid (CSF) examination showed a mild mononuclear pleocytosis (16/μl). Oligoclonal band was positive. The titer of anti-varicella zoster virus (VZV) IgG antibodies was increased, that indicated VZV reactivation in the central nervous system (CNS), although VZV DNA PCR was not detected. Therefore, acyclovir (750 mg/day for 2 weeks) and valaciclovir (3,000 mg/day for 1 month) were administered in addition to stroke therapy. He recovered to be able to walk independently 2 month after the admission.Angiography uncovered a saccular aneurysm of 3 mm at the end of branch artery of right anterior cerebral artery, Heubner artery, 28 days after the admission. We speculated that VZV vasculopathy caused by VZV reactivation in CNS was involved in the pathomechanism of cerebral infarction rather than HIV vasculopathy in the case.

  6. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, genetic homogeneity, and mapping of the locus within a 2-cM interval

    Energy Technology Data Exchange (ETDEWEB)

    Ducros, A.; Alamowitch, S.; Nagy, T. [INSERM U25, Paris (France)] [and others

    1996-01-01

    Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a recently identified autosomal dominant cerebral arteriopathy characterized by the recurrence of subcortical infarcts leading to dementia. A genetic linkage analysis conducted in two large families recently allowed us to map the affected gene on chromosome 19 in a 12-cM interval bracketed by D19S221 and D19S215. In the present study, these first 2 families and 13 additional ones, including a total of 199 potentially informative meiosis, have been genotyped with eight polymorphic markers located between D19S221 and D19S215. All families were linked to chromosome 19. The highest combined lod score (Z{sub max} = 37.24 at {theta} = .01) was obtained with marker D19S841, a new CA{sub n} microsatellite marker that we isolated from chromosome 19 cosmids. The recombinant events observed within these families were used to refine the genetic mapping of CADASIL within a 2-cM interval that is now bracketed by D19S226 and D19S199 on 19p13.1. These data strongly suggest the genetic homogeneity of this recently identified condition and establish the value of its clinical and neuroimaging diagnostic criteria. Besides their importance for the ongoing positional cloning of the CADASIL gene, these data help to refine the genetic mapping of CADASIL relative to familial hemiplegic migraine and hereditary paroxysmal cerebellar ataxia, conditions that we both mapped within the same chromosome 19 region. 35 refs., 5 figs., 2 tabs.

  7. Association of Telomere Length with Cerebral Infarction%外周血白细胞端粒长度与脑梗死的相关性研究

    Institute of Scientific and Technical Information of China (English)

    姜昕; 黄四春; 郭毅

    2012-01-01

    目的:探讨脑梗死患者外周血白细胞端粒长度的变化及二者之间的关系.方法:应用实时荧光定量PCR方法检测70例脑梗死患者(病例组)和70例健康对照者(对照组)外周血白细胞相对端粒长度的变化,同时检测2组血脂、血糖、超敏C反应蛋白、血压等指标.结果:相对端粒长度病例组和对照组分别为(0.98±0.84)、(2.05±0.98),前者显著缩短(P<0.001).结论:端粒长度的缩短与脑梗死发生具有相关性.%Objective:To investigate association of telomere length and cerebral infarction. Methods: Seventy patients with ischemic strokes were recruited for the study and 70 healthy ones were treated as the controls. Leukocyte telomere length was measured with real-time Polymerase Chain Reactions in all subjects. Blood Lipids, blood glucose, high-sensitivity C-reactive protein, blood pressure were measured. Results: The mean leukocyte telomere length of the patients was significantly shorter than that in the controls [(0. 98 ± 0. 84)&(2. 05 ± 0. 98),P<0. 001]. Conclusion: The shorten telomere length is related to cerebral infarction.

  8. 前列地尔对脑梗塞的治疗价值分析%Analysis of the Value of Alprostadil in the Treatment of Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    张力月

    2015-01-01

    Objective To investigate the value of alprostadil in the treatment of cerebral infarction. Methods 72 patients were randomly assigned into control group and observation group. The control group was Xuesetong treatment, observation group alprostadil treatment. Results The effective rate of the observation group was 86.11%, higher than that of the control group of 63.89%, The neurological function defect score in the observation group was (9.27±1.36), which was lower than that in the control group (15.34± 2.18), and the difference was statistically significant (P<0.05). Conclusion The effect of alprostadil in patients with cerebral infarction was signiifcantly high clinical value.%目的:探讨前列地尔在脑梗塞治疗中的应用价值。方法选取患者72例,按随机数字表法分为对照组与观察组。对照组采用血塞通治疗,观察组采用前列地尔治疗。结果观察组治疗有效率为86.11%,高于对照组的63.89%;观察组治疗后神经功能缺损评分为(9.27±1.36)分,低于对照组的(15.34±2.18)分,对比差异有统计学意义(P<0.05)。结论前列地尔在脑梗塞患者治疗中的效果较好。

  9. Influence of Scalp Point-through-point Acupuncture on 200 kDa Neurofilament Protein in Rats with Acute Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    李红颖; 朱文增; 东贵荣; 王凤军; 客蕊

    2007-01-01

    目的:研究头穴透刺对急性脑梗死大鼠神经丝蛋白-200(NF-200)的影响,探讨针刺对脑梗死大鼠神经可塑性影响的机制.方法:将健康雄性Wistar大鼠随机分为假手术组(A组)、模型组(B组)、针刺组(C组).通过建立大鼠局灶性脑缺血模型(MCAO),用逆转录-聚合酶链反应(RT-PCR)法,测定以上各组在7 d、14 d、28 d不同时间点NF200 mRNA变化情况.结果:头穴透刺组脑组织NF-200的表达与假手术组、造模组相比差异有统计学意义(P<0.05);而在不同时间窗内头穴透刺组,模型组与假手术组比较差异有统计学意义(P<0.01).表明头穴透刺可以促进脑组织神经丝蛋白-200的表达.结论:头穴透刺能够提高脑缺血后神经功能,促进肢体功能恢复,增加神经丝蛋白-200的表达,发挥对脑组织神经细胞可塑性的调节作用.%Objective: To investigate the effect of scalp point-through-point acupuncture on 200 kDa neurofilament protein (NF-200) in rats with acute cerebral infarction and explore its mechanism on nerve plasticity in cerebral infarction rats. Methods: Healthy male Wistar rats were randomly allocated to sham operation (Group A), model (Group B) and acupuncture (Group C) groups. A rat middle cerebral artery occlusion (MCAO) model of cerebral ischemia was made. NF-200 mRNA was measured by reverse transcriptase polymerase chain reaction (RT-PCR) in each group on the 7th, 14th and 28th days. Results: The cerebral expression of NF-200 in group C was significantly different from those in groups A and B (P<0.05); there was a significant difference between groups C and B or A at different time windows (P<0.01),indicating that scalp point-through-point acupuncture could improve the cerebral expression of NF-200. Conclusion: Scalp point-through-point acupuncture can improve neural function,promote the recovery of limb function and increase the expression of NF-200 after cerebral ischemia, exerting a regulative effect on

  10. Three-dimensional perfusion imaging in acute cerebral infarction%三维CT灌注成像在急性脑梗死中的应用

    Institute of Scientific and Technical Information of China (English)

    戴峰; 高歌军; 文颂; 颜利辉

    2009-01-01

    目的 探讨将三维CT脑灌注加权成像(PWM)和脑灌注血容量成像(PBV)整合优化到急性缺血性脑梗死脑CT灌注成像(CTP)联合脑CT血管成像(CTA)扫描方案中的价值.方法 对23例临床诊断急性脑梗死患者行CTP联合CTA检查,将增强CTA原始数据或增强CTA与平扫CTA减影的原始数据通过图像工作站处理,得到脑三维CT PWM和三维CT全脑PBV的伪彩图像,评价CTP与PWM、PBV在诊断急性脑梗死上的敏感性和整合运用的意义. 结果 23例临床诊断急性脑梗死患者,9例单纯CTP图像显示阴性患者中有7例在PWM、PBV图像上有阳性改变;单纯CTP观测急性脑梗死的敏感性约60.87%,CTP与PWM、PBV整合观测急性脑梗死的敏感性约91.30%. 结论 将三维CT脑PWM和脑PBV整合优化到急性脑梗死CT检查方案中,不仅能提高急性脑梗死的检出率,而且能预测患者预后.%Objective To assess the value of whole cerebral perfusion weighted map (PWM) and whole cerebral perfusion blood volume (PBV) integrating in scan protocol about CT perfusion (CTP) combined with CT angiography (CTA) in acute cerebral infarction. Methods Twenty-three patients with acute cerebral infarction proved clinically underwent CTP examination combined with CTA. The color-coded images of PWM and PBV were attained using workstation, and the raw data of contract CTA images and subtractive images between contract CTA and non-contract CTA were processed. The diagnostic sensitivity and the value of CTP and PWM, PBV integrating CTP in acute cerebral infraction were evaluated. Results Seven of 9 patients with negative results on CTP images had positive expressions on PWM and PBV images. The sensitivity of CTP was 60.87% and the sensitivity of PWM and PBV integrating CTP was 91.30%. Conclusion The scan protocol of PWM, PBV integrating CTP not only increases detection rate of acute cerebral infraction, but also has ability to predict the clinical prognosis of patients with cerebral

  11. Moringa Oleifera Lam Mitigates Oxidative Damage and Brain Infarct Volume in Focal Cerebral Ischemia

    OpenAIRE

    Woranan Kirisattayakul; Jintanaporn Wattanathorn; Terdthai Tong-Un; Supaporn Muchimapura; Panakaporn Wannanon

    2012-01-01

    Problem statement: At present, the therapeutic outcome of cerebral ischemia is still not in the satisfaction level. Therefore, the preventive strategy is considered. Based on the protective effect against oxidative damage of Moringa oleifera Lam. Leaves extract, we hypothesized that this plant extract might protect against cerebral ischemia, one of the challenge problems nowadays. In order to test this hypothesis, we aimed to determine the protective effect of M.oleifera leaves extract in ani...

  12. 影响急性脑梗死预后的血浆生物标志物研究进展%Research Advances in the Plasma Biomarkers for the Prognosis of Acute Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    杨纪元(综述); 费爱华(审校)

    2016-01-01

    The acute cerebral infarction is a highly prevalent disease.With its bad consequences,the acute cerebral infraction threatens human health.It is crucial for the judgment of the prognosis of ACI patients due to the various prognosis conditions with different patients .Currently the relationship between plasma bio-markers, such as homocysteine, uric acid, fibrinogen and the prognosis of cerebral infarction has already become a hotspot in the field,and it′s found that different plasma biomarkers play different roles for the initi-ation and progression of cerebral infarction.%急性脑梗死是临床多发病和常见病,其后果严重,给人类健康带来严重的危害,且不同患者的预后差异很大,因而对脑梗死患者的预后判断显得至关重要。近年来,随着研究的深入,血浆生物学标志物(如同型半胱氨酸、尿酸、纤维蛋白原等)与脑梗死预后的关系成为研究的热点。而不同类别的血浆生物标志物在脑梗死发生、发展过程中所起的作用也不尽相同。

  13. 急性脑梗死后失语症的MRI影像学研究%Analysis of MRI Manifestation with Aphasia after Acute Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    葛巍; 王敏; 朱文荣; 樊红彬; 耿德勤

    2012-01-01

    Aim: To reveal the relationship between aphasia and infarct lesion defined by MRI through analysis of 68 patients with aphasia performance after acute cerebral infarction. Methods: The potential patients were evaluated by the hand evaluation standard of Aphasia Battery of Chinese. Chinese Aphasia Examination was applied to classify the type of aphasia. The lesion site and volume of cerebral infarction in patients were determined by MRI. Results: All 68 cases of aphasia patients were right-handed. There were 18 global aphasia(GA) cases, 25 broca aphasia(BA) cases, 7 wernicke aphasia(WA) cases, 7 conduction aphasia cases, 7 transcortical motor aphasia(TCM) cases and 4 anomic aphasia(AA) cases. There were 32 cases with the classic language center and 36 cases with non-language center. Conclusion: The aphasia types were not agreed with the traditional aphasia anatomical localization, and the non-language center may also cause aphasia.%目的:应用MRI检查确定急性脑梗死后失语症类型与脑梗死部位之间的关系.方法:对68例急性脑梗死后具有失语症表现患者应用汉语失语成套测验中的利手评定标准进行利手判定和汉语失语症检查进行失语症的分类,用头颅MRI确定患者的脑梗死部位及病灶体积.结果:68例急性脑梗死失语症患者均为右利手,失语症类型分别为完全性失语18例,运动性失语25例,感觉性失语7例,传导性失语7例,经皮质运动性失语7例,命名性失语4例.累及经典语言中枢的有32例,36例为非语言中枢受累.结论:急性脑梗死失语症类型与传统的失语症解剖定位不完全符合,非语言中枢梗死也可引起失语症.

  14. Lethal hypoplasia and developmental anomalies of the lungs in a newborn with intrauterine adrenal hemorrhage and cerebral infarcts: a proposed pulmonary disruption sequence.

    Science.gov (United States)

    Lertsburapa, Terakeith; Vargas, Diana; Lambert-Messerlian, Geralyn; Tantravahi, Umadevi; Gündoğan, Füsun; DeLaMonte, Suzanne; Coyle, Mara G; De Paepe, Monique E

    2014-01-01

    We report a case of a 31-week-gestation male newborn who died soon after birth from intractable respiratory failure and persistent pulmonary hypertension. The pregnancy had been complicated by intermittent bleeding between 13 and 20 weeks' gestation, attributed to peripheral placental separation, as well as bilateral fetal adrenal hemorrhage, first detected at 17 weeks' gestation. Postmortem examination revealed small, calcified adrenal glands as well as several remote cerebral and cerebellar infarcts. The lungs were hypoplastic (lung weight/body weight ratio: 1.64%; 10th percentile for 28-36 weeks' gestation: 2.27%) and distorted by exaggerated lobulation. Microscopically, the lungs exhibited several developmental anomalies, including focal acinar dysgenesis suggestive of arrested development in the pseudoglandular stage of development (8-16 weeks' gestation) (mainly in the upper lobes), and features of bronchial obstruction, including focal lobular hyperplasia and microcystic maldevelopment (mainly in the lower lobes). The adrenal and cerebral findings were consistent with a severe early-gestation hypoxic-ischemic insult, likely related to peripheral placental separation and chronic abruption. The co-occurrence and timing of these well-recognized hypoxic lesions provide further evidence that certain developmental lung anomalies, such as focal acinar dysplasia, focal lobular hyperplasia, and microcystic maldevelopment, may, at least in some cases, have a hypoxic/ischemic etiology.

  15. 分水岭脑梗死患者的病因分析及治疗策略%Etiology analysis and treatment strategies of cerebral watershed infarction

    Institute of Scientific and Technical Information of China (English)

    陈建国; 石振东

    2015-01-01

    目的::探讨分水岭脑梗死( CWI)患者的病因及治疗策略。方法:回顾性分析55例CWI患者的病因与治疗效果。结果:55例CWI患者中颈部或脑动脉狭窄或闭塞40例,血流动力学异常38例,血液成分异常19例。结论:在脑或颈部动脉狭窄或闭塞的基础上,当血流动力学出现异常时即可发生CWI。针对病因给予相应治疗,有利于患者尽早康复。%Objective:To investigate etiology and treatment strategies of cerebral watershed infarction ( CWI) . Methods: A retrospective analysis of the etiology and treatment of 55 CWI cases was done. Results:Among the 55 CWI patients, neck or cerebral artery stenosis or occlusion occurred in 40 cases, abnormal hemodynamics happened in 38 cases, and 19 cases had abnormal blood components. Conclusions:Based on the brain or neck artery stenosis or occlusion, CWI occurs on the event of hemodynamic abnor_malities. It should give the appropriate treatment for the cause in order to promote early rehabilitation of the patients.

  16. Research Progresses of Naloxone and Prostacyclin for Treatment of Cerebral Infarction%纳洛酮和前列环素治疗脑梗死的研究进展

    Institute of Scientific and Technical Information of China (English)

    苏静

    2014-01-01

    Cerebral infarction also called ischemic stroke, is a frequently encountered diseases that severely affects the health and life qualities of middle-aged and elderly people. At present, Pathogenisis of cerebral infarction is still not clear, it has a high dis-ability rate and fatality rate, and it is easy to cause symptoms like mobility problems, language barrier and hemiplegia. The treat-ment of cerebral infarction aims to increase CBF during ischemic stage or protect brain tissue from damages during ischemic stage. This article elaborates the research progresses of naloxone and prostacyclin for treatment of cerebral infarction to offer some help for the treatment of cerebral ingarction.%脑梗塞又称缺血性卒中,是严重影响中老年人健康和生活质量的多发病,目前,关于脑梗死的发病机制尚不明确。但脑梗死致残率、致死率均较高。临床主要表现为行动不便、语言障碍、半身不遂等。脑梗死治疗的目的在于增加缺血期脑组织的血流(CBF)或是保护缺血期脑组织免受损害,本文阐述了纳洛酮和前列环素治疗脑梗死的研究进展,期望为脑梗塞的治疗提供一定的帮助。

  17. Changes in levels of serum polyamines in the patients with cerebral infarction%脑梗死患者血清腐胺、精脒、精胺水平变化

    Institute of Scientific and Technical Information of China (English)

    刘红霞; 刘新平; 李义召; 卢林; 李明欣; 傅善基

    2000-01-01

    目的动态观察脑梗死患者血清腐胺、精脒、精胺水平变化。方法选择16例脑梗死患者及26例正常人,应用高效液相色谱法测定血清腐胺、精脒、精胺水平。结果脑梗死患者发病7天内腐胺水平显著升高并达峰值,7天后开始下降,14天后仍明显高于对照组;精脒、精胺水平7天内显著低于对照组,7天后恢复并逐渐达对照组水平。脑梗死急性期腐胺水平随病情加重显著升高,精脒、精胺水平随病情加重而下降。结论聚胺代谢紊乱参与了脑梗死的病理生理过程。%Objective To study the changes in levels of serum polyamines in the patients with cerebral infarction. Methods Serum putrescine,spermidine and spermine were measured by using HPLC in 16 cases of cerebral infarction and 26 controls. Results The levels of serum putrescine in the patients with cerebral infarction were increased as compared with those in the control group. The level of serum putrescine reached its peak within 7 days,began to decrease from the 7th day and higher than in the control group after 14 days. The levels of serum spermidine and spermine in the patients with cerebral infarction were significantly decreased as compared with those in the control group within 7 days,gradually recovered and returned to that in the control group after 7 days. The severer the condition of cerebral infarction,the higher the putrescine level and the lower the spermidine and spermine levels. Conclusion Polyamines metabolic disturbance plays a major role in pathophysiological and pathogenetic mechanisms of cerebral infarction.

  18. The Related Factors of Transient Ischemic Attack Development Cerebral Infarction and Prevention Countermeasures%短暂性脑缺血发作进展为脑梗死的相关因素及预防对策

    Institute of Scientific and Technical Information of China (English)

    翟金健

    2013-01-01

    Objective:To investigate related factors of transient ischemic attack development cerebral infarction and the preventive measures. Methods:Transient ischemic attack development cerebral infarction patients 42 cases as the observation group, randomly selected the same period transient ischemic attack without progressive cerebral infarction 42 patients as control group , two groups patients were observed in initial onset of blood pressure, fasting blood glucose, blood lipid extraction detection, early onset duration, past medical history, statistically analyzed the related factors of two groups of patients. Results:Observation group patients smoking,hyperlipidemia,diab etes,high blood pressure, heart disease higher than that of control group(P<0.05),is related factors of transient ischemic attack development cerebral infarction. Conclusion:Tansient ischemic attack development cerebral infarction is the result of many factors, the implementation of the corresponding measures to prevent transient ischemic attack of cerebral infarction.%目的:探讨短暂性脑缺血发作进展为脑梗死的相关因素及预防措施。方法:选择短暂性脑缺血发作进展为脑梗死患者42例作为观察组,随机选取同期短暂性脑缺血发作未进展性脑梗死42例做为对照组,观察两组患者初次发作时血压,抽取空腹静脉血检测血糖、血脂、初发发作持续时间、既往病史,对两组患者相关因素进行了统计分析。结果观察组吸烟患、高脂血症、糖尿病、高血压、心脏病高于对照组(P<0.05),是引起短暂性脑缺血发作发展为脑梗死相关因素。结论:短暂性脑缺血发作进展为脑梗死是多种因素作用结果,实施相应措施防止短暂性脑缺血发作进展为脑梗死。

  19. Analysis of Causes and Risk Factors of Cerebral Infarction in Young Patients in Enshi Minority Area%恩施少数民族地区中青年脑梗死病因及危险因素分析

    Institute of Scientific and Technical Information of China (English)

    孟祥武; 黄淼

    2015-01-01

    Objective To investigate the etiology and control able risk of Youth Cerebral Infarction in Enshi minority area factors, provide the basis for the prevention of minority groups in Enshi Youth Cerebral infarction. Methods Retrospective analysis and related risk in Enshi minority regions in 86 patients under the age of 45 patients with cerebral infarction etiology factors. Results The Enshi national minority area in the most common etiology of the disease because of Youth Cerebral Infarction atherosclerosis, fol owed by embolization of vascular disease, hypertension, heart disease and atrial fibril ation, diabetes, hyperlipidemia, obesity, smoking, drinking, hyperhomocysteinemia are the common risk factors of cerebral infarction in young. Conclusion Search the pathogeny actively, early prevention and treatment of hypertension, hyperlipidemia and diabetes risk factors, a reasonable diet, smoking, drinking, strengthen physical exercise, weight control, changing bad habits can reduce the rate of incidence of cerebral infarction in young minority groups in Enshi.%目的探讨恩施少数民族地区中青年人脑梗死的病因及可控危险因素,为恩施少数民族地区中青年脑梗死的预防提供依据。方法回顾性分析恩施少数民族地区86例45岁以下脑梗死患者的病因及相关危险因素。结果恩施少数民族地区中青年脑梗死病因最常见的病因为动脉粥样硬化,其次为栓塞性血管病,高血压、心脏疾病并房颤、糖尿病、高血脂、肥胖、吸烟、酗酒、高同型半胱氨酸血症等是中青年脑梗死的常见危险因素。结论积极寻找病因,早期防治高血压、高血脂和糖尿病等危险因素,合理饮食,戒烟、戒酒,加强体育锻炼,控制体重,改变不良生活习惯可以降低恩施少数民族地区中青年脑梗死发病率。

  20. 脑梗死患者轻度肾功能损伤的相关研究%Research on cerebral infarction patients with mild renal impairment

    Institute of Scientific and Technical Information of China (English)

    李娟; 张敏; 夏章勇

    2014-01-01

    Objective To investigate the risk factors of mild renal impairment in cerebral infarction patients.Methods One hundred and fifty patients with cerebral infarction were enrolled from June 2012 to June 2013,and all patients received cranial magnetic resonance imaging at the first week.The clinical data of patients were recorded in detail,24 h microalbuminuria (mALB) was detected,renal function was assessed.According to mALB,the patients were divided into normal renal function group (105 cases) and mild renal dysfunction group (45 cases).Clinical risk factors between 2 groups were compared,and multivariate regression analysis was done.Results Age in mild renal dysfunction group was greater than that in normal renal function group [(67.04 ±9.37) years vs.(63.01 ± 11.18) years],the incidence of hypertension and multiple lacunar infarction were higher than those in normal renal function group[57.8% (26/45) vs.33.3% (35/105),57.8% (26/45) vs.22.9% (24/105)],leukoaraiosis grade was higher than that in normal renal function group,there were significant differences (P < 0.05 or < 0.01).Logistic regression analysis found that hypertension (OR =1.04 1,P =0.045) and leukoaraiosis (OR =2.048,P =0.000) were independent risk factors for cerebral infarction patients with mild renal impairment.Conclusions The incidence of mild renal impairment is higher in cerebral infarction patients,and is closely related to hypertension and leukoariosis.Early detection of 24 h mALB in cerebral infarction patients has important clinical significance.%目的 探讨脑梗死患者轻度肾功能损伤的相关危险因素.方法 选择2012年6月至2013年6月收治的脑梗死患者150例,均行磁共振检查,详细记录患者的临床资料,并检测24 h尿微量白蛋白(mALB),评估肾功能.根据mALB分为肾功能正常组(105例)及轻度肾功能损伤组(45例).比较两组临床危险因素,并进行多因素回归分析.结果 轻度肾功能损伤组患者

  1. Analysis of related risk factors of progressive ischemic cerebral infarction%进展性脑梗死相关危险因素分析

    Institute of Scientific and Technical Information of China (English)

    王霆; 蒋纯新; 江宏杰; 张永祥; 翁翔; 黄孝飞; 沈俊

    2013-01-01

    Objective To investigate the related risk factors that caused progressive ischemic cerebral stroke. Methods 246 cases which were admissioned our hospital from May 2008 to May 2011 were studied retrospectively, according to evolving clinical course, which were labelled into progressive cerebral infarction ( PCI) group and nonprogressive cerebral infarction ( NPCI) group, studied items included age, history of hypertension, diabtes millitus, coronary heart disease, stroke, hyperlipocholemia, smoking and alcohol drinking, scores of neurological function,blood pressure of admission,the decreasing of blood pressure after admission,fever ,serum lipoprotein level , serum glucose, heamocrits, stenosis of carotid and intracranial arteries, then analysized them respectively. Results History of Diabtes Millitus, early decreasing blood pressure , temputure of admission 24 hours, leukocytes counting, serum glaucose, infarction lesion adjacent to lateral ventricals, stenosis of intracranial and internal carotid arteries were more signifiantly in statistics in PCI group than that of NPCI group ( P < 0.05 ) . Conclusion PCI is related to those risk factors of history of Diabtes Millitus,early decreasing blood pressure,fever ,leukocytes increasing,elevating serum glucose ,infarction lesion adjacent to lateral ventricals,stenosis of intracranial and internal carotid arteries.%目的 探寻引起脑梗死进展的相关危险因素.方法 对我院2008年5月-2011年5月住院的急性脑梗死患者246例,根据入院后病情演变分为进展性脑梗死组(PCI)和非进展性脑梗死组(NPCI).观察项目包括年龄、高血压史、糖尿病史、冠心病史、脑卒中病史、高脂血症史、吸烟史及饮酒史,入院时神经功能评分、入院时高血压、入院后血压降低、发热、血脂、血糖、红细胞压积、颈动脉狭窄及颅内动脉狭窄进行分析.结果 PCI组的糖尿病史、早期不适当降压治疗、颅内动脉狭窄

  2. Effects of movement training on synaptic interface structure in the sensorimotor cortex and hippocampal CA3 area of the ischemic hemisphere in cerebral infarction rats

    Institute of Scientific and Technical Information of China (English)

    Min Yang; Jiyan Cheng

    2008-01-01

    BACKGROUND: Movement is an effective way to provide sensory, movement and reflectivity afferent stimulation to the central nervous system. Movement plays an important role in functional recombination and compensation in the brain. OBJECTIVE: To observe movement training effects on texture parameters of synaptic interfaces in the sensorimotor cortex and hippocampal CA3 area of the ischemic hemisphere and on motor function in cerebral infarction rats. DESIGN, TIME AND SETTING: This neural morphology and pathology randomized controlled animal experiment was performed at the Center Laboratory, Affiliated Hospital of Luzhou Medical College, China from November 2004 to April 2005. MATERIALS: A total of 32 healthy male Wistar rats aged 8 weeks were equally and randomly assigned into model and movement training groups. METHODS: Rat models of right middle cerebral artery occlusion were established using the suture occlusion method in both groups. Rats in the movement training group underwent balance training, screen training, and rotating rod training starting on day 5 after surgery, for 40 minutes every day, 6 days per week, for 4 weeks. MAIN OUTCOME MEASURES: Texture parameters of synaptic interfaces were determined using a transmission electron microscope and image analyzer during week 5 following model induction. The following parameters were measured: synaptic cleft width; postsynaptic density thickness; synaptic interface curvature; and active zone length. Motor function was assessed using balance training, screen training, and rotating rod training. The lower score indicated a better motor function. RESULTS: The postsynaptic density thickness, synaptic interface curvature, and active zone length were significantly increased in the sensorimotor cortex and hippocampal CA3 area of the ischemic hemisphere of rats from the movement training group compared with the model group (P < 0.05 or 0.01). Curved synapses and perforated synapses were seen in the sensorimotor cortex

  3. 大脑前动脉供血区梗死患者的临床分析%Clinical analysis of patients with anterior cerebral artery territory infarction

    Institute of Scientific and Technical Information of China (English)

    陈红兵; 王莹; 杨智云; 洪华

    2011-01-01

    目的 探讨大脑前动脉(ACA)供血区梗死的危险因素、病因、临床和影像学特征.方法 回顾性分析ACA供血区急性脑梗死患者的临床和影像学资料,对其危险因素、病因、梗死灶的分布和临床表现进行总结.比较其中栓塞组(心源性或颈动脉源性栓塞)和ACA粥样硬化组患者梗死灶的分布和临床表现.结果 共纳入44例患者进行研究,占同期住院急性缺血性卒中的4.9%.前3位危险因素为高血压(81.8%)、高脂血症(38.6%)和吸烟(38.6%).TOAST分型:心源性栓塞的有6例(13.6%),大动脉粥样硬化的有33例(75%),其他原因的有2例(4.5%),病因不确定的有3例(6.8%).栓塞组(16/44,36.4%)和ACA粥样硬化组(24/44,54.5%)单发梗死分别为10例(62.5%)和3例(12.5%),χ2=10.940,P<0.001;梗死累及皮质的分别为14例(87.5%)和11例(45.8%),χ2=7.112,P<0.01;梗死累及皮质下白质分别为2例(12.5%)和16例(66.7%),χ2=11.381,P<0.001;梗死累及胼胝体分别的为6例(37.5%)和19例(79.2%),χ2=7.112,P<0.01;梗死累及ACA以外区域分别的为5例(31.3%)和0例(0),P=0.007.ACA粥样硬化组情感障碍的有11例(45.8%),栓塞组有2例(12.5%),χ2=4.862,P=0.040;其他临床表现,两组比较差异无统计学意义(P>0.05).结论 ACA梗死较少见.高血压是最重要的危险因素;ACA粥样硬化闭塞性病变是其主要病因.ACA粥样硬化闭塞性病变所致梗死灶的分布明显不同于心源性或颈动脉源性栓塞,表明两者致ACA梗死的机制存在差异.%Objective To investigate the risk factors, etiology, clinical and imaging characteristics of anterior cerebral artery (ACA) territory infarction in Chinese patients. Methods The clinical and neuroradiological data of the patients with acute ACA territory infarction were reviewed. The risk factors,etiology, distributions of infarct lesions, and clinical manifestations of the patients were summarized. The distribution of infarct lesions and clinical

  4. Use of decompressive craniectomy in the treatment of hemispheric infarction Uso da craniectomia descompressiva no tratamento do acidente vascular cerebral isquêmico hemisférico

    Directory of Open Access Journals (Sweden)

    José Antonio Fiorot Jr.

    2008-06-01

    Full Text Available Decompressive craniectomy (DC has demonstrated efficacy in reducing mortality in hemispheric infarction of the middle cerebral artery. The aim of our study was to compare the outcome of patients submitted to DC to patients treated in a conservative way. Eighteen patients were submitted to DC and 14 received conservative treatment. Neurological status was assessed by the Glasgow Coma Score and National Institutes of Health Stroke Scale score. Mortality, modified Rankin Scale and Barthel Index scores were assessed at 90 days to evaluate outcome. We did not observe reduction in overall mortality and functional outcome in patients submitted to DC. The differences between our group and previously published series are probably related to the neurological status of the patients at the time of therapeutic decision.Craniectomia descompressiva (CD tem demonstrado eficácia em reduzir a mortalidade em pacientes com infarto hemisférico (IH da artéria cerebral média. Este estudo avaliou o prognóstico dos pacientes submetidos a CD comparando a pacientes com IH tratados de maneira conservadora. Dezoito pacientes foram submetidos a CD e 14 receberam tratamento conservador. Escala de Coma de Glasgow e Escala de AVC do National Institutes of Health foram utilizadas para graduar o déficit neurológico. A mortalidade, bem como os escores obtidos na escala modificada de Rankin e índice de Barthel foram avaliados em 90 dias. Não foi observada redução de mortalidade nos pacientes submetidos a CD. Essa diferença entre os nossos resultados e os estudos publicados previamente se deve, provavelmente, à decisão cirúrgica tardia em pacientes com sinais clínicos de herniação cerebral.

  5. Infarto cerebral secundario a trombosis de la carótida interna por traumatismo cervical Cerebral infarction secondary to internal carotid thrombosis following cervical trauma

    OpenAIRE

    Rico, A.; Santos, M; R. Marín; Blanco, M; Sánchez, A.; R. González-Cámpora; J. Lucena

    2011-01-01

    Se presenta el caso de una trombosis postraumática de la arteria carótida interna en un varón de 33 años, tras recibir un golpe con un balón en el cuello. La muerte se produjo 10 días después del golpe como consecuencia de un cuadro de hipertensión intracraneal y herniación cerebral secundaria a infarto isquémico extenso que afectaba a todo el territorio de la arteria cerebral media derecha, tanto superficial como profundo.In this paper, a case of post-traumatic thrombosis in the internal car...

  6. Transient ischemic attack clinical analysis of correlative factors of cerebral infarction%短暂性脑缺血发作进展为脑梗死相关因素的临床分析

    Institute of Scientific and Technical Information of China (English)

    郎凤东; 任芳

    2013-01-01

      Objective To investigate the effect of transient ischemic attack(TIA) the factors responsible for the development of cerebral infarction. Methods 143 patients with transient cerebral ischemia in our hospital from 2010 March-2013 year in January the attack patients as the object of study, retrospective analysis of the clinical data of their. Results By analyzing the clinical data of 143 cases of patients in the analysis, patient gender, history of coronary heart disease, alcohol and tobacco, hyperlipemia and transient ischemic attack of cerebral infarction and no significant association(P >0.05); patients age, diabetes, hypertension and cerebral artery stenosis in patients with transient cerebral ischemia cerebral infarction has a significant association(P 0.05);高龄、糖尿病、高血压及脑动脉狭窄等有显著性关联(P <0.05);发作频率在3次/d以上、有严重神经功能缺损、发作时间持续高于30min的患者,其TIA进展为脑梗死显著性增高(P <0.05)。结论 TIA进展为脑梗死是由多种因素共同作用的结果,尤其与病患年龄较高,患有糖尿病、高血压、脑动脉狭窄及发作频率过高等有关,值得临床重点关注。

  7. Anticorpos antifosfolípides em 66 pacientes com infarto cerebral entre 15 e 40 anos Antiphospholipid antibodies in 66 patients with cerebral infarction between 15 and 40 years old

    Directory of Open Access Journals (Sweden)

    José Ibiapina Siqueira Neto

    1996-12-01

    Full Text Available Os anticorpos antifosfolípides (aFLs constituem grupo heterogêneo de imunoglobulinas que tem sido relacionado com alterações na coagulabilidade. Indivíduos com títulos elevados teriam maior probabilidade de desenvolver tromboses de repetição, tanto arterial como venosa, e por conseguinte infarto cerebral (IC. Os testes para detecção mais utilizados em estudos clínicos são o inibidor lúpico e a anticardiolipina. Têm-se relatado maiores percentuais de positividade nesses testes em pacientes jovens com IC. Neste estudo procuramos investigar a prevalência desses anticorpos em pacientes com IC entre 15 e 40 anos em nosso Serviço. Examinamos 66 pacientes para presença de aFLs e obtivemos 16,65% de resultados positivos. Confirmamos diagnóstico de síndrome do anticorpo antifosfolípide primária em três (4,55% casos. Concluímos que a pesquisa de rotina para aFLs em pacientes jovens com IC está indicada neste grupo de pacientes, mas correlacioná-los com o episódio isquêmico nem sempre é possível.The antiphospholipid antibodies (aPLs are a heterogenous group of immunoglobulins that have been related with alterations in blood coagulability in recent years. Patients with elevated titers of these antibodies have a high probability to develop thrombotic events, including cerebral infarct (CI. The tests currently used to detect these antibodies are the lupus anticoagulant and ELISA for anticardiolipin antibodies which have a larger proportion of positivity among young patients with CI. In our study we tested 66 patients with cerebral infarcts whose ages ranged from 15 to 40 years for the presence of lupus anticoagulant and anticardiolipin antibodies. The results showed that eleven (16.65% patients were positive for aPLs and three (4.55% of them fulfilled the diagnostic criteria for primary antiphospholipid syndrome. These data point out to the importance of investigating aPLs in young patients with CI and its high prevalence in this

  8. Analysis of 8 cases of the performance of pseudo subarachnoid hemorrhage of acute cerebral infarction%表现为假性蛛网膜下腔出血的急性脑梗死8例分析

    Institute of Scientific and Technical Information of China (English)

    张梅芳; 易婷玉; 吴燕敏; 陈文伙

    2015-01-01

    目的:探讨表现为假性蛛网膜下腔出血的急性脑梗死的原因.方法:收治急性脑梗死患者8例,分析临床表现及影像学表现.结果:右侧偏瘫及失语3例,左侧偏瘫3例,视野异常2例.头颅MRI显示急性脑梗死8例,左侧额叶3例,其中2例合并皮层下分水岭梗死,右侧额叶3例,均合并皮层下分水岭梗死,右侧枕叶2例, MRA提示脑血管狭窄、闭塞5例,左侧大脑中动脉重度狭窄2例,右侧大脑中动脉闭塞2例,右侧大脑中动脉重度狭窄1例.结论:急性大脑皮层梗死早期因代偿脑膜支血流缓慢,易在CT表现为假性蛛网膜下腔出血.%Objective:To explore the manifestations of acute cerebral pseudo subarachnoid hemorrhage causes.Methods:8 patients with acute cerebral infarction were selected,analysis of clinical manifestation and imaging performance.Results:On the right side of 3 cases of hemiplegia and aphasia,3 cases of left hemiplegia,2 cases of abnormal visual field.Brain MRI showed acute cerebral infarction in 8 cases,left frontal lobe in 3 cases,2 cases with cerebral watershed infarction,right frontal lobe in 3 cases,2 cases of right occipital lobe,5 cases of cerebral artery stenosis,2 cases of left middle cerebral artery stenosis,2 cases of right middle cerebral artery occlusion,right middle cerebral artery stenosis in 1 cases.Conclusion:Acute cortical infarction due to compensatory meningeal branch blood flow is slow,easy to show in CT as a pseudo subarachnoid hemorrhage.

  9. Relationship between abnormal blood rheology and development and recovery of hypertension and cerebral infarction%血液流变学异常与高血压和脑梗死发生、转归的相关性

    Institute of Scientific and Technical Information of China (English)

    赵刚

    2002-01-01

    Background:Increased blood pressure in hypertension is related to vessels resistance,cardiac output,as well as blood viscosity.Stroke is common following hypertension.A number of studies reported that abnormal blood rheology was frequent in stroke suggesting correlation of blood rheology with onset,development,recovery of hypertension.Hypertension is the most one of independent risk factors of stroke.In the current paper,we investigated pathogenesis and development of hypertension and cerebral infarction to provide principle foundation for early prevention and treatment of cerebral infarciton.

  10. CLINICAL ANALYSIS OF 84 PATIENTS WITH CEREBRAL WATERSHED INFARCTION%脑分水岭梗死84例临床分析

    Institute of Scientific and Technical Information of China (English)

    孔德权

    2012-01-01

    Objective To analyze the clinical feature and relevant factors of cerebral watershed infarction( CWI) in order to provide the reference for treatment and prevention. Methods The medical history, physical examination, auxiliary examination and prognosis of 84 patients with CWI were reviewed. Results The onset of 47 cases( 55. 95% )was during rest,26 cases( 30. 95% )during sleep, llcases ( 13. 10% ) during activity. Of all the patients, 61. 90% ,38. 09%, 21. 43%, 16. 67% and 35. 71% respectively were combined with hypertension,dyslipidemia,coronary heart disease,hyperhomocysteinemia and diabetes mellitus. Seventy point two four percent and 54. 76% of all had smoking and drinking history. 84. 52%of all were detected with vascular narrowing or block,and mild,moderate and severe level accounted for 14. 94% ,40. 23% and 44. 83%. Middle cerebral artery stenosis or occlusion, internal carotid stenosis or occlusion accounted for 43. 68% and 42. 53%. S - CWI angiopathy rate was the highest, thereinto, middle cerebral artery angiopathy was the most( P < 0. 01 ). The internal carotid angiopathy rate of C - CWI was the highest( P <0. 01 ). The cure rate was 41. 67% , obvious effective rate was 51. 19% , effective rate was 7. 14%. Conclusion CWI was related to systemic circulation, middle cerebral artery and internal carotid stenosis or occlusion. If treated earlier, the serious injure can be prevented.%目的 分析脑分水岭梗死(cerebral watershed infarction,CWI)临床特征及相关因素,为临床预防和治疗提供依据.方法 回顾性分析CWI患者84例的病史、体格检查、辅助检查及预后转归等临床资料.结果 安静时起病47例(55.95%),睡眠时起病26例(30.95%),活动时起病11例(13.10%).合并高血压、血脂异常、冠状动脉粥样硬化性心脏病、高同型半胱氨酸血症、糖尿病分别为52例(61.90%)、18例(38.09%)、18例(21.43%)、14例(16.67%)、30例(35.71%);既往有吸烟、饮酒史占59例(70.24%)、46例(54

  11. Effect of ultraviolet blood irradiation and oxygenation on nerve function and function of the red blood cell membrane pump in patients with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    Jiaquan Wang; Chun Mao; Kaifu Ma; Shiqing Wang

    2006-01-01

    BACKGROUND: Ultraviolet blood irradiation and oxygenation (UBIO) has obtained better clinical effect in treating acute cerebral infarction, but the mechanism underlying this effect remains unclear.OBJECTIVE: To observe the effect of UBIO on the nerve function and activities of K+-Na+-ATPase and Ca2+-Mg2+-ATPase activities on the red blood cell (RBC) membrane of patients with acute cerebral infarction.DESIGN: A randomized and controlled study.SETTING: Department of Neurology, Xiangfan Central Hospital.PARTICIPANTS: From January 2000 to December 2001, excluding those above 70 years old, 58 cases of 700 patients with acute cerebral infarction admitted in the Department of Neurology, Xiangfan Central Hospital, were recruited and divided into two groups according to the random number table: UBIO treated group (n=28), including 17 males and 11 females, aged 40-68 years; and control group (n=30), including 20males and 10 females, aged 44-69 years. All the patients agreed to participate in the therapeutic program and detected items. The general informations were comparable without obvious differences between the two groups (P > 0.05).METHODS: ① The patients in both groups received routine treatments, besides, those in the UBIO treated group were given UBIO treatment by using the XL-200 type therapeutic apparatus produced in Shijiazhuang, whose ultraviolet wave was set at 253.7 nm with the energy density of 0.568 J/m2 per second, UBIO treatment started from the second day after admission, once every other day, with a single course consisting of 5-7 treatments. ② In the UBIO treated group, the venous blood was sampled before and after the first, third and the completion of the treatment course respectively, the venous blood was taken at each corresponding time point in the control group. After centrifugation of the blood at 10 000 rounds per minute,the RBC membrane was separated and then the activities of K+-Na+-ATPase and Ca2+-Mg2+-ATPase were detected by means of

  12. 神经干细胞移植等方法治疗脑梗死后遗症的策略研究%Strategy study of treatment for cerebral infarction sequelae using neural stem cell transplantation

    Institute of Scientific and Technical Information of China (English)

    陈小玉; 段云霞; 方亮; 张梓倩; 刘庆山

    2011-01-01

    背景:国内外动物模型的研究已经表明干细胞移植对脑梗死的治疗可以起到积极作用,在行为恢复和缩小梗死面积临床试验也有一定的成果.目的:通过分析和总结2000年以来国内外多种方法治疗脑梗死后遗症的研究,探讨各疗法的优缺点,寻求最佳的治疗途径.方法:分别以"脑梗死后遗症、脑卒中后遗症"," Cerebral infarction sequelae hemiplegia"等为检索词,应用计算机检索万方数据知识服务平台及Pubmed 数据库2000-01/2010-10有关文章,保留22篇文献做进一步分析.结果与结论:神经干细胞治疗脑梗死后遗症的方法主要集中在外源性神经干细胞移植后整合、补充或替代受损及内源性神经干细胞损伤后在细胞因子等的作用下激活修复.神经保护疗法主要是针对缺血性级联反应的各种通路,保护因缺血、缺氧而受损伤但仍有活力的神经元,逆转半暗带,降低再灌注损伤对脑神经细胞的损伤,减少梗死面积,进行有针对性的治疗.理疗及功能康复、民族药物多种方法的应用也为脑梗死后遗症的治疗带来了希望.其中调节在体神经干细胞增殖和分化,促进神经系统的功能修复是未来药物研究的重要研究目标.%BACKGROUND: Studies have demonstrated that stem cell transplantation plays a positive role in treatment of cerebral infarction,which also has good outcome in recovery and diminution of infarct size in clinical trials.OBJECTIVE: By analyzing and summarizing the research which adopts treatment of cerebral infarction sequelae in past ten years,we devote to discuss the strength and weakness of those treatments and find a suitable treatment of cerebral infarction sequelae.METHODS: Application of computer technology to retrieve the articles in wanfang data and PubMed database on spinal cord tissue engineering from 2000 January to 2010 October. Words for retrieve were "cerebral infarction sequelae, neural stem cells

  13. 电刺激对脑梗死大鼠运动功能和Rho激酶表达的影响%Effects of electric stimulation on motor function and the expression of Rho kinase following cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    陈涛; 张秀清; 唐吉友

    2010-01-01

    目的 探讨单侧与双侧电刺激对脑梗死大鼠肢体运动功能和Rho激酶表达的影响.方法 采用线栓法制作Sprague-Dawley大鼠大脑中动脉永久性闭塞模型,将造模成功且存活的脑梗死大鼠分为假手术组、对照组、单侧电刺激组、双侧电刺激组(各36只),假手术组、对照组自然恢复,单、双侧电刺激组接受电刺激治疗.利用平衡木试验(BWT)观察造模后第3天、第7天、第14天和第21天各组大鼠运动功能恢复情况,同时采用免疫组化染色法检测脑梗死灶周边区Rho激酶的表达水平,采用2,3,5-氯化三苯基四氮唑(TTC)染色法检测脑梗死灶体积的变化.结果 第7,14,21天,电刺激组大鼠BWT评分明显高于对照组(P0.05),第21天脑梗死灶体积显著缩小(P0.05).结论 早期电刺激能够促进脑梗死大鼠运动功能的恢复,并且促进脑梗死灶体积缩小,双侧电刺激疗效优于单侧电刺激,其机制可能与下调脑梗死灶周边区Rho激酶的表达有关.%Objective To investigate the effects of electric stimulation on motor function and expression of Rho kinase following cerebral infarction in rats. Methods Acute cerebral infarction was modeled in adult male Sprague-Dawley ( SD) rats using the permanent middle cerebral artery occlusion ( PMCAO) technique. The rats were randomly divided into sham operation, control, unilateral electric stimulation and bilateral electric stimulation groups ( each group had 36 rats). Electric stimulation was applied to the paralyzed ( unilateral or bilateral) limbs in the last two groups. Motor function recovery and the expression of Rho kinase were examined using a beam walking test ( BWT) and immunohistochemistry respectively at the 3rd, 7th, 14th and 21st day after stimulation. In addition, the cerebral infarction volume was also determined by 2, 3, 5-triphenyl tetrazolium chloride (TTC) staining at different time points. Results Motor function improved significantly in the

  14. The Relevant Risk Factors in Elderly Patients with Anemia Combined with Cerebral Infarction%老年贫血合并脑梗死患者的临床相关危险因素分析

    Institute of Scientific and Technical Information of China (English)

    李宇; 杨萍; 萨丽波; 陈玉菲

    2015-01-01

    Objective:To analyze the pathogenesis and risk factors of cerebral infarction in elderly patients with anemia Method:380 elderly patients with anemia combined with cerebral infarction were selected as the research object,according to the result of hemoglobin on admission,they were divided into the anemia cerebral infarction group (113 cases)and non anemia cerebral infarction group(267 cases),the history and the relevant examination 13 factors such as the single factor analysis,and place the meaningful single factor in the multi-factor Logistic regression analysis. Result:13 risk factors were compared among the anemia group in patients with cerebral infarction and nor anemia group, and we found that age,gender,NIHSS score,history of coronary heart disease,chronic renal failure,hemorrhagic cerebrovascular disease history,smoking and drinking difference between groups were statistically significant(P<0.05). Compared with the control group,age(OR 1.03;95%CI 1.01-1.05),chronic renal failure(OR 1.42;95%CI 1.03-1.92) and hemorrhagic cerebrovascular disease history(OR 3.42;95%CI 1.18-9.43)is independent risk factors for cerebral infarction.Conclusion:Compared with non anemia cerebral infarction group,age,history of chronic renal failure and hemorrhagic cerebrovascular disease were the independent risk factors for cerebral infarction.%目的:分析老年贫血患者合并脑梗死的发病机制和危险因素。方法:选取380例神经内科及老年科治疗的≥60周岁的老年脑梗死患者为研究对象,根据入院时血红蛋白结果分为贫血性脑梗死组113例和非贫血性脑梗死组267例,对患者的病史、入院情况及相关检查等13个因素进行单因素分析,并将有意义的单因素进行多因素Logistic回归分析。结果:对贫血性脑梗死与非贫血性脑梗死患者中可能相关的13个因素进行比较,发现年龄、性别、NIHSS评分、冠心病病史、慢性肾衰竭、出血性脑血管病病史、

  15. Research Progress on the Correlation between Microalbuminuria and Cerebral Infarction%微量白蛋白尿与脑梗死相关性的研究进展

    Institute of Scientific and Technical Information of China (English)

    高宇; 宗静杰; 王淑颖; 郑建刚

    2011-01-01

    通过对近10年来微量白蛋白尿与脑梗死的相关性文献的梳理,指出动脉粥样硬化、高血压、糖尿病、心脏病及高脂血症是脑梗死的危险因素,而微量白蛋白尿与这些危险因素密切相关,提示微量白蛋白尿对脑梗死的诊断、治疗及预后评估有重要意义.%Atherosclerosis, high blood pressure,diabetes,heart disease,hyperlipidemia,all of them are the risk factors of cerebral infarction. Microalbuminuria was significantly correlated with these risk factors,and microalbuminuria has important indicative function for the diagnosis and the treatment and the prognostic evalnation of cerebral infarction.

  16. 针刺治疗脑梗死所致假性延髓麻痹吞咽困难60例%Sixty cases of pseudobulbar palsy dysphagia induced by cerebral infarction treated with acupuncture

    Institute of Scientific and Technical Information of China (English)

    郝服; 董宇翔; HU Jing

    2010-01-01

    @@ Pseudobulbar palsy is one of the severe complications of cerebral infarction.The etiology is central paralysis induced by that bilateral upper motor neuron injury(including to motor cortex and corticobulbar tract mainly)makes cranial motor nuclei in medulla lose the innervation from upper motor neuron.Its clinical manifestation is the central paralysis of tongue,soft palate,throat,facial muscle and masticatory muscles.It mainly manifests as dysphagia,irritating cough,dysarthria and so on.Among them,respiratory tract infection,nutritional deficiency,water-electrolyte imbalance and even lifethreatening sequelae usually appear in patients with dysphagia,and there has not a relatively ideal therapy aiming at this condition currently.The authors treated sixty cases of pseudobulbar palsy dysphagia induced by cerebral infarction with acupuncture combined with routine medicine.The report is as follows.

  17. Clinical analysis of 35 cases of magnetic resonance imaging in the diagnosis of cerebral infarction%核磁共振成像诊断脑梗死35例临床分析

    Institute of Scientific and Technical Information of China (English)

    韩永来

    2015-01-01

    Objective: To investigate and analyze the application of nuclear magnetic resonance imaging in diagnosis of cerebral infarction.Methods: all patients underwent GE Siemens3.0T MRI scanner diagnosis, axial normal or fast SE sequence scanning T1WI, T2WI, DWI, observed lesions in magnetic resonance imaging map, and compared with the surrounding tissue. Results: 35 patients were diagnosed as cerebral infarction, magnetic resonance images can clearly see a circular, speckled and cloud signal, overall diagnostic accuracy was 88.6%, 52 lesions were found in 26 cases, infarction shape sector or triangle, 6 cases of punctate, 3 cases of irregular shape.Magnetic resonance image analysis of cerebral infarction occurred mainly in the parietal lobe, temporal lobe and occipital lobe.Conclusion: MRI diagnosis of cerebral infarction and the high accuracy, can provide useful information for the early diagnosis of cerebral infarction.%目的:探讨分析核磁共振成像在脑梗死临床诊断中的应用价值。方法所有患者进行GE Siemens3.0T核磁扫描仪进行检查诊断,进行横轴位常规或快速SE序列平扫T1WI、T2WI、DWI,观察病变在核磁共振成像图上的表现,以及与周围组织的对比。结果35例患者均被诊断为脑梗死,核磁共振图像中均可清晰看到有圆形、斑点状和云雾状信号,总体诊断准确率为88.6%,共发现病灶52个,梗死形态呈扇形或三角形的26例,斑点状的6例,不规则形状的3例。核磁共振图像分析脑梗死主要发生在顶叶、颞叶和枕叶。结论核磁共振成像对脑梗死的诊断准确率较高,可为脑梗死的早期诊断提供有益的信息依据。

  18. 伴基底节钙化的婴幼儿外伤后腔隙性脑梗塞%Pusttraumatic cerebral lacunar infarction in infants with basal ganglia calcifications

    Institute of Scientific and Technical Information of China (English)

    金惠明; 孙莲萍; 鲍南

    2001-01-01

    Objective To explore the pathologic mechanism and treatment of posttraumatic cerebral lacunar infarction in infants with basal ganglia calcifications. Methods The symptoms, radiation demonstrations, treatments and prognosis in 20 infants undergoing cerebral infarction following minor cerebral trauma were reviewed retrospectively. Results Posttraumatic cerebral infarctions all occurred in only one side of basal ganglia. It leads to acute hemiplegia in the patients, but no changes of consciousness and no signs of intracranial hypertension were noted. CT scan showed punctate calcification in bilateral basal ganglia and lacunar infarction just beside them. After treatment the infants recovered well within 3months. Conclusions The occurrence of posttraumatic cerebral lacunar infarction is closely associated with basal ganglia calcification, but its mechanism is not clear. It needs to be differentiated from cerebral toxoplasmosis and cytomegalic inclusion disease.%目的探讨伴有基底节钙化的婴幼儿外伤后腔隙性脑梗塞的发病机理和治疗效果。方法总结20例婴幼儿较轻微头颅外伤后发生脑梗塞的症状、影像学表现、治疗效果及预后。结果婴幼儿外伤后脑梗塞均发生于一侧基底节区。l临床表现为不同程度的一侧急性偏瘫、无意识改变及颅内高压症状。CT扫描发现双侧基底节区存在细小点状钙化,腔隙性脑梗塞灶毗邻钙化点。经治疗预后好,随访3个月全部康复。结论婴幼儿外伤后腔隙性脑梗塞的发生与基底节钙化关系密切。但发病机理及基底节钙化的生理过程尚有待探究。本病诊断需与脑弓形虫病及巨细胞包涵体病等相鉴别。

  19. 健康教育在脑梗塞后遗症患者中的应用%Application of Health Education in the Sequelae of Cerebral Infarction Pa-tients

    Institute of Scientific and Technical Information of China (English)

    孙艳辉

    2016-01-01

    We Analysed the Health Education content sequelae of cerebral infarction patients, obtained the importance of health education at the time of application sequelae of cerebral infarction patients. The main content of sequelae of cerebral infarction patient health education, including three aspects.They were health education basics of education, psychological care and self-care precautions. Among them, the independent care considerations included postural care, diet care, nursing complications. These nursing content, not only can improve patients' knowledge and skills sequelae of cerebral infarction care, supervision and nurses, but also improve patient compliance and self-care initiative.%通过分析健康教育在脑梗塞后遗症患者中的应用内容,得出健康教育在脑梗塞后遗症患者中的应用时的重要意义。脑梗塞后遗症患者的健康教育的主要内容,包括健康教育基本知识宣教、心理护理和自主护理注意事项3个方面。其中,自主护理注意事项包括了体位护理、饮食护理、并发症护理。通过这些护理内容,不仅能够提高患者关于脑梗塞后遗症护理的知识和技能,监督护士工作,还能提高患者自我护理的依从性和主动性。

  20. 脑梗死后出现抑郁焦虑症状的影响因素分析%Analysis of factors affecting the symptoms of depression and anxiety in the patients with cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    李杰; 张垚

    2015-01-01

    Objective To explore the influence factors of anxiety and depression after cerebral infarction.Methods using the self rating Depression Scale (SDS), self ratingAnxiety Scale (SAS) were performed in 200 patients by grading the risk factors ofdepression and anxiety after cerebral infarction analysis.Results multivariate analysis showed that the risk factors after cerebral infarction, including different lesion location,duration, marital status, there is no concomitant diseases, times of cerebral infarction,family history, the degree of neural function defect.Conclusion the common symptoms of depression and anxiety after stroke, and is affected by many factors, seriously affect therecovery of neural function and daily ability recovery, should be paid attention to.%目的:探讨脑梗死后抑郁焦虑症状的影响因素。方法采用自评抑郁量表(SDS)、自评焦虑量表(SAS)对200例患者进行评分测定,对脑梗死后抑郁焦虑状态的危险因素进行分析。结果多因素分析提示脑梗死后的危险因素包括不同病变部位、病程、婚姻状况、有无伴发疾病、脑梗死次数、家族史、神经功能缺损程度。结论脑卒中后的抑郁焦虑症状常见,且受多种因素影响,严重影响神经功能康复和日常能力的恢复,应予以重视。

  1. Correlation between Serum Omentin-1 and Type 2 Diabetes Complicated by Cerebral Infarction%2型糖尿病合并脑梗死与网膜素-1的相关性研究

    Institute of Scientific and Technical Information of China (English)

    贾瑞超; 张玺; 毕璐洁; 段玉玲; 王宏

    2014-01-01

    Objective To investigate the correlation between serum omentin-1 and type 2 diabetes complicated by cerebral infarction through detecting the changes in serum omentin-1 levels in patients with type 2 diabetes,patients with non-diabetic cerebral infarction and patients with type 2 diabetes and cerebral infarction. Methods Serum omentin-1 levels were measured by double antibody sandwich ELISA in 33 patients with type 2 diabetes (type 2 diabetes group),30 patients with type 2 diabetes compli-cated by cerebral infarction (diabetic cerebral infarction group),33 patients with non-diabetic cerebral infarction(non-diabetic cerebral infarction group),and 30 healthy subjects(control group). In addition,body mass index was calculated and levels of total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDL-C)and high density lipoprotein cholesterol (HDL-C),glycosylated hemoglobin (HbAlc) and fasting plasma glucose (FPG)were detected. The relationships of levels of omentin-1 to levels of HbAlc and FPG were analyzed. Results Compared with control group,levels of HbAlc,FPG and TC increased but levels of omentin-1 decreased in type 2 diabetes group, levels of HbAlc,FPG and TG increased but levels of omentin-1 decreased in diabetic cerebral infarction group, and levels of omentin-1 decreased in non-diabetic cerebral infarction group (P<0.05 or P<0.01). Compared with diabetic cerebral infarction group,levels of HbAlc decreased in type 2 diabetes group and non-diabetic cerebral infarction group (P<0.05). Compared with non-diabetic cerebral infarction group,levels of HbAlc and FPG increased in type 2 diabetes group, and levels of HbAlc and FPG increased but levels of omentin-1 decreased in diabetic cerebral infarction group (P<0.05 or P<0.01). Serum levels of omentin-1 were negatively correlated with levels of HbAlc and FPG in patients with type 2 diabetes complicated by cerebral infarction (r=-0.264 and r=-0.285, respectively;P<0.01). Conclusion Serum omentin-1

  2. The Clinical Diagnosis of the Hemorrhagic Cerebral Infarction of the Nuclear Magnetic Resonance Imaging%分析出血性脑梗死患者核磁共振成像的临床诊断

    Institute of Scientific and Technical Information of China (English)

    王思坚

    2014-01-01

    Objective To observe and analysis research of hemorrhagic cerebral infarction of the clinical data of nuclear magnetic resonance imaging. Methods From May 2013 to May 2013 of our hospital, 30 cases of hemorrhagic cerebral infarction mri imaging data were retrospectively analyzed. Results The MRI performance for a total of 30 cases of hemorrhagic cerebral infarction, 16 cases which occur in the temporal lobe, temporal top 6 patients with occipital lobe, temporal and occipital lobe in 5 cases, temporal and parietal in 2 cases, front temporal and parietal in 1 case. Conclusion MRI of hemorrhagic cerebral infarction through information cognition and has great clinical value of diagnosis and treatment.%目的:观察和分析研究出出血性脑梗死(hemorrhagic infarction)患者核磁共振成像(MRI)的临床资料。方法选取2013年5月~2014年5月我院收治的30例出血性脑梗死的核磁共振成像的影像学资料进行回顾性分析。结果 MRI表现为出血性脑梗死共30例,其中发生在颞叶16例,发生在颞顶枕叶6例,发生在颞枕叶5例,发生在颞顶叶2例,发生在额颞顶叶1例。结论通过资料得出MRI对出血性脑梗死的认知与诊治都有很大的临床价值。

  3. 标准大骨瓣减压术治疗大面积脑梗死临床分析%Clinical analysis of standard hemicraniectomy for massive cerebral infarct

    Institute of Scientific and Technical Information of China (English)

    冯伟; 李兆全; 韩大明

    2013-01-01

    Objective To investigate the clinical effect of standard hemicraniectomy on massive cerebral infarct.Methods The clinical data of 36 patients with massive cerebral infarct,who underwent standard hemicraniectomy from August 2008 to May 2012,were analyzed retrospectively.Results According to Glasgow outcome scale on discharge from hospital,among the 36 patients with massive cerebral infarct,22 cases(61.1%) recovered,3 cases(8.3%) with moderate disability,5 cases(13.9%) with severe deficit,2 cases(5.6%) survived vegetatively and 4 cases (11.1%) died.Conclusions Standard hemicraniectomy is an effective method to treat massive cerebral infarct.Early surgery can reduce complications and reduce mortality and morbidity.%目的 探讨标准大骨瓣减压术治疗大面积脑梗死的临床疗效.方法 回顾性分析2008年8月至2012年5月行标准大骨瓣开颅减压术治疗的36例大面积脑梗死患者的临床资料.结果 出院时按GOS分级,36例大面积脑梗死患者中恢复良好22例(61.1%),轻残3例(8.3%),重残5例(13.9%),植物生存2例(5.6%),死亡4例(11.1%).结论 标准大骨瓣减压术是治疗大面积脑梗死的有效方法,早期手术可以减少并发症,降低病死率及致残率.

  4. S100蛋白检测在脑梗死中的应用研究%Study of application of S100 protein detection in cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    李江; 张然蓉; 李钢; 罗历; 郝建华

    2014-01-01

    Objective To investigate the application value of S100 protein detection in cerebral infarction (CI). Methods Seventy-six CI patients admitted to our hospital from January 2012 to April 2013 were analyzed. The patients'S100 protein levels on day 3,7 and 14 were detected and their correlation to neurological deficits and cerebral infarction lesion size was studied. Meanwhile,56 healthy people receiving physical examination in the corresponding period received contrast analysis. Results (1)S100 protein levels were significantly different between the CI group and the control group on postoperative day 3 and day 7,P<0.01, P<0.05.(2)S100 protein levels were significantly different between middle,severe and mild neurological deficits,P < 0.05,P < 0.01.(3)The middle,large and small-sized infarction groups were significantly different (P < 0.05,P < 0.01). Conclusion S100 protein is highly expressed in the early stage of CI onset and meanwhile its high expression is closely related to the degree of neurological deficits and the size of infarction, which indicates that S100 protein has certain correlation to the pathological and physiological process of CI.%目的:探讨S100蛋白检测在脑梗死(CI)中的作用价值。方法分析我院自2012年1月~2013年4月收治的76例CI患者,检测S100蛋白在CI患者发病后第3、7、14天时的水平,以及与神经功能缺损评分、脑梗死病灶面积大小的关系。同时选取我院同期行健康体检患者56例进行对照分析。结果(1)CI组与对照组比较,在术后3d与7d时,S100蛋白水平比较,P<0.01,P<0.05。(2)神经功能缺损评分中型、重型组与轻型组S100蛋白水平比较,P<0.05,P<0.01。(3)梗死面积中、大组与小梗死面积组比较,P<0.05, P<0.01。结论 S100蛋白在CI发病早期为高表达,同时其高表达神经功能缺损严重程度及梗死面积增大有密切关系,表明S100蛋白与CI的病理、生理的过程有一定的相关性。

  5. 脑梗死患者血清可溶性血管细胞黏附分子1的变化%Variation of soluble vascular cell adhesion molecule-1 in serum of patients with cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    李静; 周华东; 王延江

    2006-01-01

    平明显高于无感染(P<0.01).结论:可溶性血管细胞黏附分子1参与了脑梗死的病理变化过程,可作为脑梗死时病情变化的监测指标.阻断其生成和表达为改善脑梗死的预后提供了新的思路.%BACKGROUND: In subjects with different inflammatory and autoimmune diseases, soluble vascular cell adhesion molecule-1 (sVCAM-1) in sera increases, and its change may become an important monitoring index of immunological function, but its change rule has been unclear in acute cerebral infarction.OBJECTIVE: To observe the change of sVCAM-1 in sera of subjects with cerebral infarction and its clinical significance, and compare between the subjects with cerebral hemorrhage and normal population.DESIGN: A case controlled analysis.SETTING: Second Department of Brain, Research Institute of Surgery,Daping Hospital, Third Military Medical University of Chinese PLA.PARTICIPANTS: A total of 132 inpatients were selected from Second Department of Brain, Research Institute of Surgery, Daping Hospital, Third Military Medical University of Chinese PLA between May 2002 and April 2004. Among them, 89 subjects with cerebral infarction were classified into large infarction group (n=25,> 10 cm3), medium infarction group (n=31,4-10 cm3) and small infarction group (n=33, < 4 cm3) respectively according to the size of infarct focus. There were 43 subjects in cerebral hemorrhage group, and 30 healthy persons were as normal control group.METHODS: Blood samples were isolated from subjects with cerebral infarction at hour 24, days 3, 7 and 14 after onset of the disease, while the blood samples were extracted from subjects with cerebral hemorrhage at hour24 and day 14 after the onset of the disease. 4 mL venous blood was obtained from the three groups. The serum concentration of sVCAM-1 was determined with double antibody sandwich method (DASM) in all the examinees.MAIN OUTCOME MEASURES: ①Dynamic change of the serum concentration of sVCAM-1 in the course of acute cerebral

  6. 依达拉奉联合奥扎格雷钠治疗急性脑梗死的临床分析%Clinical Analysis of Edaravone Combined with Ozagrel Sodium in the Treatment of Acute Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    陈玉萍

    2015-01-01

    Objective To observe the clinical curative effect of edaravone combined with sodium ozagrel in the treatment of patients with acute cerebral infarction. MethodsThe clinical data of 82 cases of patients with acute cerebral infarction.ResultsThe score of neural function defect, the effective rate of the treatment were compared between two groups(P<0.05).Conclusion Edaravone and ozagrel sodium can be used as the drug of choice in the treatment of acute cerebral infarction.%目的 观察应用依达拉奉联合奥扎格雷钠治疗急性脑梗死患者的临床疗效.方法 选取82例急性脑梗死患者的临床资料.结果 两组患者的神经功能缺损评分、治疗有效率对比(P<0.05).结论 可将依达拉奉和奥扎格雷钠作为治疗急性脑梗死患者的首选药物.

  7. 胞二磷胆碱治疗早期急性脑梗死临床观察%Clinical Observation of Citicoline in the Treatment of Early Acute Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    陈丽娟

    2015-01-01

    Objective To observe the clinical ef ects of citicoline for early acute cerebral infarction.Methods 91 cases of acute cerebral infarction were randomly divided into citicoline group,edaravone group and piracetam group compared three treatment groups.Results The three groups no significant dif erence in treatment ef ect.Conclusion Citicoline for the treatment of acute cerebral infarction, to determine the ef icacy,low incidence of adverse reactions,and inexpensive.Worthy of promotion.%目的:观察胞二磷胆碱用于早期急性脑梗死的临床效果。方法将91例急性脑梗死随机分为胞二磷胆碱组、依达拉奉组及吡拉西坦组,比较三组治疗效果。结果三组治疗效果无明显差异。结论胞二磷胆碱用于急性脑梗死治疗,疗效确定,不良反应发生率低,且价格低廉。

  8. Migraine Infarction. Case Report

    Directory of Open Access Journals (Sweden)

    Yoany Mesa Barrera

    2015-03-01

    Full Text Available Migraine is considered like a risk factor for ischemic ictus in adult young people. In spite of the criteria established for the treatment of the migraine infarct, they are not always fulfilled strictly, permitting certain flexibility in the aforementioned treatment. The case of a patient with a background of migraine with auras, who suffers an ischemic cerebral migraine infarct at the course of a migraine crisis, is pr