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  1. ESTRÉS OXIDATIVO EN PECES INDUCIDO POR CONTAMINANTES AMBIENTALES

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    DM Ochoa

    2008-01-01

    Full Text Available el estrés oxidativo inducido por diversas clases de contaminantes como mecanismo de toxicidad ha sido un foco de interés en el campo de la toxicología acuática y ambiental durante la última década. numerosas evidencias indican que muchos de estos agentes con-taminantes al llegar a cuerpos de agua pueden desencadenar el proceso de estrés oxidativo en organismos que allí habitan, y son responsables de efectos en células y tejidos asociados a mutagénesis y carcinogénesis. el estrés oxidativo se genera cuando existe una sobrecar-ga en la formación de radicales libres o agentes prooxidantes, la cual no es debidamente compensada por los mecanismos de defensa antioxidante que posee el organismo. Los fac-tores que son importantes al momento de la presentación del proceso de estrés oxidativo en peces, así como los mecanismos de defensa contra el ataque de agentes prooxidantes y las consecuencias de dicho evento, se revisarán en el presente artículo.

  2. Síndrome de neurotoxicidad inducido por opioides (NIO Opioid induced-neurotoxicity syndrome (OIN

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    M. L. Cid

    2008-12-01

    Full Text Available El síndrome de neurotoxicidad inducido por opioides (NIO es uno de los efectos adversos del uso de estos fármacos descrito en los últimos años. Su aparición de debe a la acumulación de metabolitos tóxicos, principalmente el M3 Glucurónido de la morfina; los cuáles pueden provocar hiperexcitabilidad neuronal, con desarrollo de alteraciones cognitivas, delirium, alucinaciones, mioclonias, convulsiones e hiperalgesia. Especialmente vulnerables a estos efectos son los pacientes mayores o con factores de riesgo como insuficiencia renal o deshidratación. Su manejo incluye principalmente la prevención de su aparición, con el manejo de factores precipitantes; disminución o rotación de opioides y manejo sintomático, intentando mantener siempre un buen control del dolor.The opioid induced neurotoxicity (OIN is an adverse effect for opioids use, described in the last years. Because the accumulation of toxic metabolites, especially M3 Glucuronide of morphine, cause neuronal hiperexcitability, patients can develop cognitive failure, delirium, hallucinations, myoclonus, seizures and hyperalgesia. The most vulnerable patients are old people, patients with dehydration and renal failure. Its treatment include prevention, with the management of trigger factors, decrease or change opioids and symptomatic management, trying to keep the good control of pain.

  3. Tratamiento de agrandamiento gingival inducido por fenitoina asociado a placa bacteriana

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    Carmen Julia Rovira

    2013-10-01

    Full Text Available ResumenLa ingesta de algunos medicamentos puede producir un sobre crecimiento de las encías. Se reportan medicamentos tales como los bloqueadores de los canales de calcio, inmunosupresores, anticonvulsivantes que producen estos efectos adversos. Múltiples casos de agrandamientos gingivales están asociados a la ingesta de Fenitoína. El tratamiento de los agrandamientos gingivales inducidos por drogas por lo general es quirúrgico, pero mantener un buen control de placa bacteriana puede evitar en muchos casos que se presente un exagerado aumento de volumen gingival. Se presenta un caso de agrandamiento gingival en paciente masculino de 22 años de edad, bajo tratamiento antiepiléptico con fenitoína. Al examen clínico se observó aumento del volumen gingival de forma generalizada, en maxilar superior e inferior, predominante en sector anterior, produciendo ardor y sangrado durante el cepillado y la ingestión de alimentos. Al sondaje presenta múltiples pseudobolsas en los diferentes cuadrantes. La radiografía panorámica reveló pérdida ósea moderada horizontal, predominante en el sector posterosuperior, posteroinferior y anteroinferior. El plan de tratamiento consistió en fase higiénica, instrucción y motivación en higiene oral a la madre, gingivectomía y gingivoplastía en ambos maxilares. (DUAZARY 2011 No. 2, 226 - 231Abstract The importance of endodontic treatment is to achieve a complete filling and sealing of the root canal to prevent the transport of contaminants to and from root canal, with materials compatible with the surrounding tissues. Occasionally a situation may arise in which the purpose of the maintenance of working length is compromised such as overenlargement. This situation allows the extrusion of filling materials, mainly sealer cements, causing post treatment complications such as inflammatory reactions, injury to adjacent structures (orbital pain, inferior alveolar nerve injury, headache, etc., and infections

  4. EL REFORZAMIENTO CONDICIONADO DE LA RESPUESTA PROCURADORA DE AGUA EN LA SITUACIÓN DE BEBER INDUCIDO POR EL PROGRAMA

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    CHRISTIAN LÓPEZ; Carlos A. Bruner

    2011-01-01

    Investigaciones anteriores en nuestro laboratorio mostraron que es posible establecer una discriminación operante en la situación de Beber Inducido por el Programa ( bip ), reforzando diferencialmente la respuesta que produce el agua en presencia de un estímulo arbitrario. Dado que un estimulo discriminativo simultáneamente adquiere la función de reforzador condicionado, en el presente experimento se probó esta función del estímulo durante la extinción de la respuesta que previamente pro...

  5. Lípidos transmisores y condicionamientos inducidos por cocaína: papel de las aciletanolamidas y el ácido lisofosfático

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    Luque Rojas, María Jesús

    2012-01-01

    La presente Tesis Doctoral tiene como objetivo la evaluación del papel de tres lípidos transmisores (endocannabinoides, oleiletanolamida y ácido lisofosfatídico), que están estructuralmente relacionados en la adquisición y expresión de los condicionamientos inducidos por cocaína. El primer conjunto de estudios se centró en el rol de los endocannabinoides que juegan un importante papel modulador de la neurotransmisión dopaminérgica. Es decir, el sustrato de actuación de la cocaína y por ello s...

  6. Dolor irruptivo oncológico inducido por radioterapia: ¿es posible optimizar su tratamiento?

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    L. Olay Gayoso

    2015-08-01

    Full Text Available Introducción: en el contexto de la radioterapia, el control del dolor irruptivo oncológico (DIO supone un reto especial. El DIO ha sido definido por la Sociedad Española del Dolor (SED, la Sociedad Española de Oncología Médica (SEOM y la Sociedad Española de Cuidados Paliativos (SECPAL como una exacerbación del dolor súbita y transitoria, de gran intensidad (EVA > 7 y de corta duración (inferior a 20-30 minutos, que aparece sobre la base de un dolor persistente estable cuando este se encuentra reducido a un nivel tolerable (EVA 6 en las últimas 24-48 h. Se establecieron controles en el momento basal, y a los 3, 7, 15 y 30 días. Resultados: se apreció un descenso en la media de los valores en la escala EVA según avanzó el estudio (EVA = 6 en el control 0 a EVA = 3 en el control 3, y las diferencias fueron significativas (p < 0,0001. La satisfacción con el tratamiento fue calificada como buena o excelente por el 85,3% de los pacientes y por el 92,7% de los investigadores. Conclusiones: los resultados de este estudio demuestran la eficacia del tratamiento del DIO con fentanilo sublingual en el contexto del tratamiento oncológico radioterápico, con un descenso significativo en los valores EVA frente al valor basal. La elevada satisfacción de los médicos y pacientes con este tratamiento refleja la eficacia y la comodidad del fentanilo sublingual en el control del DIO.

  7. Efecto de la cerveza frente al estrés oxidativo inducido por la adriamicina.

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    Torres Rodríguez, Mª Carmen

    2007-01-01

    RESUMEN La cerveza es una bebida alcohólica de baja graduación resultante de fermentar mediante levadura seleccionada el mosto procedente de malta de cebada, sólo o mezclado con otros productos amiláceos transformables en azúcares por digestión enzimática, cocción y aromatizado con flores de lúpulo. Los constituyentes de la cerveza provienen de sus cuatro principales materias primas, malta, lùpulo, agua y levadura. El principal componente de la cerveza es el agua, que se acompaña de otros ...

  8. Evaluación de los efectos del policosanol sobre manifestaciones del daño pulmonar inducido por monocrotalina en ratas

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    Vivian Molina

    2009-01-01

    Full Text Available La hipertensión arterial pulmonar, (HTAP enfermedad crónica que afecta frecuentemente a la población adulta, conduce a una discapacidad importante y progresiva. Las estatinas, agentes hipolipemiantes que inhiben la síntesis de colesterol mediante la inhibición competitiva de la HMG-CoA reductasa que además inhiben la proliferación de las células musculares lisas (CML, han sido referidas como una opción actual para tratar esta enfermedad. El policosanol es una mezcla de alcoholes alifáticos superiores obtenida de la cera de caña que también inhibe la síntesis de colesterol mediante la regulación indirecta de la actividad de la HMG-CoA reductasa, con acción antiproliferativa sobre las CML. Resulta racional investigar si el policosanol protege el daño pulmonar inducido en modelos experimentales en los cuales las estatinas han mostrado ser efectivas. Este estudio investigó los efectos del tratamiento oral con policosanol sobre el daño pulmonar inducido por monocrotalina (MCT en ratas. Para ello, las ratas se distribuyeron en cuatro grupos: un control negativo tratado vía subcutánea (s.c. con disolución salina y por vía oral con el vehículo tween 20/agua y tres inyectados con dosis s.c. únicas de MCT (60 mg/kg, uno tratado por vía oral con el vehículo (control positivo y dos con policosanol (20 y 200 mg/kg. Los tratamientos comenzaron el día de la inyección con MCT y se administraron por 28 d . Se cuantificó el porcentaje de supervivencia, el peso corporal, el peso del pulmón completo, la hipertrofia ventricular y se realizó el estudio histológico. La MCT aumentó significativamente el peso del pulmón, redujo significativamente el peso corporal y produjo marcada hipertrofia ventricular derecha y severa hipertrofia de la capa media arterial, mostrando la validez del modelo. Contrario a lo esperado, al compararse con los datos del control positivo, el policosanol (20 y 200 mg/kg no modificó significativamente ninguna

  9. Nivel de corte de los ELISAs para cuantificación de anticuerpos inducidos por la vacuna antimeningocócica VA-MENGOC-BC

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    Rolando Ochoa

    2001-06-01

    Full Text Available Para medir el grado de protección inducido por vacunas antimeningocócicas se ha establecido el Ensayo Bactericida en Suero (EBS y se perfeccionan otros ensayos inmunobiológicos, sin embargo, es necesario contar con pruebas sencillas como el ELISA, capaz de evaluar un gran número de muestras. Se estimó el nivel de corte de los ELISAs para la cuantificación de IgG humana contra los antígenos de VA-MENGOC-BC, vacuna antimeningocócica compuesta por vesículas proteicas de membrana externa de meningococo B y polisacárido capsular de meningococo C, con respecto a un panel de muestras de suero de lactantes, caracterizado por Ensayo Bactericida en Sangre Total (EBST. Los valores correspondientes a la máxima sensibilidad y especificidad fueron respectivamente; 2 μg/mL y 12 μg/mL para antipolisacárido C, y 1000 U/mL y 7000 U/mL para antiproteínas de membrana externa. La mayor coincidencia se obtuvo con 6 μg/mL y 2500 U/mL. Se evaluó otro panel de muestras de suero de adolescentes entre 14 y 18 años, por ELISA y EBS para Neisseria meningitidis serogrupos B y C, alcanzándose una buena concordancia. Doce años después de la inmunización con VA-MENGOC-BC persiste una importante concentración de anticuerpos contra los antígenos vacunales en los sueros estudiados.

  10. Efectos del D-004, extracto lipídico de los frutos de la Palma Real (Roystonea regia), sobre el granuloma inducido por algodón en ratas y sobre la lipoxigenasa presente en leucocitos polimorfonucleares (PMNs)

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    Menéndez, Roberto; Carvajal, Daysi; Mas, Rosa; Pérez, Yohanis; Molina, Vivian; Arruzazabala, María de Lourdes; González, Rosa María

    2006-01-01

    El D-004 es un extracto lipídico del fruto de la palma real (Roystonea regia, Arecaceae), en el cual los ácidos oleico, laurico y palmítico son los principales componentes. La administración oral inhibe significativamente la hiperplasia prostática inducida por testosterona en roedores. El objetivo del presente trabajo consistió en investigar los efectos anti-inflamatorios inducidos por el tratamiento oral con D-004 en el modelo de granuloma por algodón y sus efectos in vitro sobre la activida...

  11. Estudio del daño en el ADN inducido por compuestos polifenólicos de la dieta

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    Burgos Morón, Estefanía

    2015-01-01

    El cáncer es una enfermedad causada por la acumulación de daño en el ADN . Las células cancerosas presentan numerosas alteraciones genéticas, epigenéticas y cromosómicas, que juegan un papel fundamental en el desarrollo de la enfermedad . Estas alteraciones pueden producirse como consecuencia del propio funcionamiento celular. Por ejemplo, se sabe que las especies reactivas de oxígeno generadas durante la respiración celular y los errores cometidos por las enzimas ADN polimerasas durante la r...

  12. Dolor óseo inducido por cáncer metastásico: fisiopatología y tratamiento

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    Isaías Salas-Herrera

    2004-03-01

    Full Text Available Se estima que de un 60 a 84% de los pacientes con cáncer desarrollan metástasis óseas. De estos un 70% experimentan síndrome s dolorosos de difícil manejo, de los cuales un 50% muere sin un adecuado alivio del dolor con una pobre calidad de vida. Por tanto, es necesario contar con medicamentos accesibles y efectivos para el manejo de esta patología. El objetivo de este artículo es revisar la fisiopatología del dolor en hueso y describir los medicamentos que se utilizan con más frecuencia en el manejo de este tipo de dolor por cáncer. Además se presenta un algoritmo de 6 pasos que permite orientar al médico al momento de tomar una decisión terapéutica.

  13. Dolor óseo inducido por cáncer metastásico: fisiopatología y tratamiento

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    Isaías Salas-Herrera; Luis Carlos Huertas-Gabert

    2004-01-01

    Se estima que de un 60 a 84% de los pacientes con cáncer desarrollan metástasis óseas. De estos un 70% experimentan síndrome s dolorosos de difícil manejo, de los cuales un 50% muere sin un adecuado alivio del dolor con una pobre calidad de vida. Por tanto, es necesario contar con medicamentos accesibles y efectivos para el manejo de esta patología. El objetivo de este artículo es revisar la fisiopatología del dolor en hueso y describir los medicamentos que se utilizan con más frecuencia en e...

  14. Cambios morfológicos inducidos por terapia génica con factor de crecimiento insulino-símil tipo I (IGF-I) prolactinomas experimentales

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    Camihort, Gisela; Luna, Georgina; Hereñu, Claudia Beatriz; Bracamonte, María; Rodolfo G Goya; Cónsole, Gloria Miriam

    2010-01-01

    Analizar los cambios morfológicos y funcionales que produce la terapia génica, implementada mediante inyección intrapituitaria de un vector adenoviral RAd-IGFI, sobre las diferentes poblaciones pituitarias en prolactinomas E-inducidos

  15. Daño inducido en el ADN plasmidial por la radiación mixta de neutrones térmicos + rayos gamma en presencia y ausencia de capturador de radicales libres

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    Maritza Rodríguez-Gual

    2010-01-01

    Full Text Available En este trabajo se cuantifica por primera vez el daño en ADN plasmidial inducido por la radiación mixta de neutrones térmicos + rayos gamma. Para el estudio fue utilizado el plasmidio pBs KS+ de 2 961 pb en disolución acuosa a 88 ng/¿L a concentraciones de 0, 2 y 20 mmol/L de glicerina que actúa como un capturador de radicales libres. Este plasmidio cambia su forma superenrollada para circular cuando es producida una rotura simple en su cadena y adquiere una forma linear cuando se produce una rotura doble en su cadena. Cuantificando las fracciones que se producen de cada una de estas formas es posible estimar el efecto de la radiación en el ADN. Las irradiaciones fueron realizadas en el canal radial # 3 del reactor de investigaciones IEA-R1 del Instituto de Pesquisas Energéticas y Nucleares de São Paulo, Brasil. Las formas del ADN fueron separadas mediante la electroforesis en gel de agarosa. En la cuantificación se utilizó el programa GelAnalis. Las fracciones de ADN en sus diferentes formas fueron graficadas en función de la dosis y ajustadas a funciones exponenciales y lineares para obtener las probabilidades de roturas simples y dobles en la cadena de ADN normalizadas por dosis y por masa molecular. Los resultados evidenciaron la acción protectora del capturador de radicales libres contra el daño inducido por la radiación, lo cual corrobora resultados anteriores obtenidos con otras radiaciones ionizantes. Los rendimientos de SSB y DSB serán de interés para la validación de diferentes modelos que intentan reproducir los resultados experimentales.

  16. Medición del daño genético inducido por el basuco en linfocitos humanos empleando la prueba de micronúcleos con Citocalasina B

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    Ocampo AP.

    2001-06-01

    Full Text Available El bazuco es una mezcla compleja que se deriva del proceso de extracción de la cocaína. El frecuente consumo de bazuco constituye un problema de salud pública. La prueba de micronúcleos en linfocitos humanos de sangre periférica por bloqueo de la citocinesis con Citocalasina B, es más sensible y precisa para evaluar daño  cromosómico porque permite registrar micronúcleos originados de fragmentos de cromosomas o cromosomas enteros en células que se han dividido una sola vez. El objetivo del presente estudio fue evaluar el daño genético, inducido por el bazuco en linfocitos humanos in vitro empleando la prueba de micronúcleos con Citocalasina B.

  17. Muerte cerebral causada por consumo de psicofármacos

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    Iglesias Rozas, José Rafael, 1942-

    1987-01-01

    Tres imágenes de una biopsia de un cerebro en estado de muerte cerebral causada por consumo de psicofármacos. Three pictures of a biopsy of a brain that has died because of consumption of psychoactive drugs.

  18. Efectos de las Ramificaciones y de los Edificios en los Voltajes Inducidos por Rayos en Líneas de Distribución Urbanas The Effects of Line Laterals and Nearby Buildings on Lightning-Induced Voltages in Urban Distribution Lines

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    A. Piantini

    2004-01-01

    Full Text Available Se presentan algunos resultados experimentales, de los efectos de las ramificaciones y de los edificios cercanos, en los voltajes inducidos por rayos en líneas de distribución urbanas. Usando un modelo en escala reducida de 1:50, las pruebas fueron realizadas considerando una típica configuración de línea de distribución, incluyendo la simulación del conductor neutral, ramificaciones, edificios y equipos como los pararrayos y transformadores. Se presentan comparaciones entre voltajes inducidos en los terminales de alto voltaje del transformador para diferentes alturas de los edificios y situaciones del transformador. Los resultados muestran que en algunas circunstancias las ramificaciones y la presencia de estructuras cercanas a la línea pueden afectar significativamente los voltajes inducidos por descargas atmosféricasSome experimental results are presented from research on the effects of laterals and nearby buildings on the lightning-induced voltages in urban overhead distribution lines. By making use of a 1:50 scale model, tests were performed considering a typical distribution line configuration, including the simulation of the neutral conductor, laterals, buildings, and equipment such as arresters and transformers. Comparisons between voltages induced at the HV transformer terminals are presented for different building heights and transformer locations. The results show that in some circumstances the laterals and the presence of structures close to the lines may significantly affect the induced voltages

  19. Efecto protector de los isotiocianatos y organosulfurados solos o en combinación con la vitamina C frente al daño al DNA inducido por la N-nitrosopiperidina y la N-nitrosobutilamina: mecanismos de acción

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    García Pérez, Almudena

    2010-01-01

    El objetivo de este trabajo de investigación consistió en evaluar el “Efecto protector de los compuestos isotiocianatos (ITCs) y de los organosulfurados (OSCs) solos o en combinación con la vitamina C frente al daño al DNA inducido por la N-nitrosopiperidina (NPIP) y la N-nitrosodibutilamina (NDBA). Así como, en determinar los mecanismos de acción por los que estos compuestos ejercen su efecto protector”. Los resultados obtenidos mostraron que las N-nitrosaminas causan daño alquilativo y oxid...

  20. Papel de p38-MAPK en el proceso de apoptosis inducido por cisplatino en células epiteliales de túbulo renal

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    Rodríguez García, María Elena

    2008-01-01

    El cisplatino es un agente alquilante de ADN con probada eficacia en el tratamiento de tumores sólidos y algunas formas de leucemia. Sin embargo, una de las principales desventajas de las terapias basadas en su uso es su nefrotoxicidad, debido al daño y a la muerte de células del epitelio tubular. En este trabajo se analiza la regulación de MAPKs (proteínas quinasas activadas por mitógenos) y su relación con el proceso de apoptosis provocado por cisplatino en células renales. Se observa que, ...

  1. Receptores de la prostaglandina E2 implicados en los trastornos motores digestivos y la fiebre inducidos por endotoxinas en la oveja: Papel de los macrófagos

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    Gimeno Soriano, Aurora; Plaza Carrión, Miguel Ángel; Castro López, Marta

    2014-01-01

    El objetivo general de este trabajo ha sido el estudio de los mecanismos fisiopatológicos implicados en la fiebre y en las alteraciones motoras digestivas inducidas por una endotoxina bacteriana: el lipopolisacárido (LPS) de Escherichia coli en la oveja. Se ha estudiado la participación de los receptores de la prostaglandina (PG) E2 (EP1, EP2, EP3 y EP4), los tipos celulares que están implicados en la síntesis y liberación de PGs en el hipotálamo y bulbo raquídeo y la posible participación de...

  2. Deterioro cognitivo inducido por privación de sueño : efecto de la edad y tratamiento con memantina.

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    Tarragón Cros, Ernesto

    2013-01-01

    La esperanza de vida y la prevalencia de enfermedades neurodegenerativas asociadas a la edad continua in crescendo, por lo que el deterioro cognitivo asociado al envejecimiento y la perdida de memoria son problemas acuciantes en el ámbito de la salud. La memantina, antagonista de los receptores NMDA de glutamato, es un fármaco de elección en la enfermedad de Alzheimer. Los objetivos de esta tesis son, pues: i) investigar el efecto de la edad y la privación de sueño en un modelo animal de ...

  3. Efecto del precondicionamiento oxidativo con Ozono en el daño intestinal inducido por isquemia/reperfusión en ratas

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    Danae Basanta Fortes; Zullyt Zamora Rodríguez; Yaima Martínez; Esmir Camps Calzadilla; Mercedes Gámez Fonseca; Víctor Rodríguez Sosa; Daisy Ferrer Marrero

    2010-01-01

    La isquemia/reperfusión intestinal constituye un fenómeno común en múltiples situaciones clínicas, tales como: la isquemia mesentérica, el shock hemorrágico y el trasplante de intestino, entre otras. La gran cantidad de alteraciones fisiopatológicas que lo acompañan contribuyen al daño irreversible del órgano. El ozono posee propiedades muy importantes, dentro de las cuales se destaca su capacidad antioxidante, razón por la cual se investigó si era capaz de proteger al intestino contra el dañ...

  4. EFECTO NEFROPROTECTOR DEL ÁCIDO ASCÓRBICO EN UN MODELO DE DAÑO RENAL INDUCIDO POR GENTAMICINA EN CONEJOS

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    Javier Antonio Padilla Funes

    2013-08-01

    Full Text Available Objetivo. Uno de los efectos secundarios mas notables de la Gentamicina es su nefrotoxicidad. En este estudio se propone el posible efecto nefroprotector del acido ascorbico como barredor de radicales libres de oxigeno. Metodología. Se ejecuto un estudio experimental en 24 conejos machos, raza Nueva Zelanda, cuyo peso fue de 1,5 +/- 0,5 Kg. Los sujetos experimentales fueron distribuidos en tres grupos. El grupo Control se manejo con Gentamicina a dosis de 80 mg/Kg/dia por via IM. El grupo Acido Ascorbico se trato a dosis de 200 mg/kg/dia via IP y Gentamicina 80mg/Kg/dia IM. El grupo Sham se manejo con SSN 0,9% por via IP e IM, durante cinco dias consecutivos, para cada grupo. Se determinaron los siguientes parametros: creatinina serica, N-Acetil s-D glucosaminidasa urinaria (NAG-U, diuresis e histopatologia de las muestras renales. Resultados. La creatinina serica fue significativamente mayor para el grupo Control respecto al grupo Acido Ascorbico (p<0,05. Respecto a la diuresis, se observo una tendencia a la poliuria en el grupo Control. En cuanto a NAG-U, se observo inhibicion completa de la actividad enzimatica en el grupo Acido Ascorbico. El analisis histopatologico demuestra hallazgos de necrosis tubular aguda en el 100% del grupo control, mientras que en el grupo Acido Ascorbico se obtuvo en un 50% de los sujetos unicamente detritos intraluminales. Conclusiones. La administracion concomitante de Acido Ascorbico con Gentamicina, disminuye significativamente el dano tubular renal, evidenciado en los valores de creatinina serica, NAG, diuresis e histopatologia renal.

  5. EFECTO NEFROPROTECTOR DEL ÁCIDO ASCÓRBICO EN UN MODELO DE DAÑO RENAL INDUCIDO POR GENTAMICINA EN CONEJOS

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    Javier Antonio Padilla Funes

    2012-01-01

    Full Text Available Objetivo. Uno de los efectos secundarios más notables de la Gentamicina es su nefrotoxicidad. En este estudio se propone el posible efecto nefroprotector del ácido ascórbico como barredor de radicales libres de oxígeno. Metodología. Se ejecutó un estudio experimental en 24 conejos machos, raza Nueva Zelanda, cuyo peso fue de 1,5 +/- 0,5 Kg. Los sujetos experimentales fueron distribuidos en tres grupos. El grupo Control se manejó con Gentamicina a dosis de 80 mg/Kg/día por vía IM. El grupo Ácido Ascórbico se trató a dosis de 200 mg/kg/día vía IP y Gentamicina 80mg/Kg/día IM. El grupo Sham se manejó con SSN 0,9% por vía IP e IM, durante cinco días consecutivos, para cada grupo. Se determinaron los siguientes parámetros: creatinina sérica, N-Acetil ß-D glucosaminidasa urinaria (NAG-U, diuresis e histopatología de las muestras renales. Resultados. La creatinina sérica fue significativamente mayor para el grupo Control respecto al grupo Ácido Ascór- bico (p<0,05. Respecto a la diuresis, se observó una tendencia a la poliuria en el grupo Control. En cuanto a NAG-U, se observó inhibición completa de la actividad enzimática en el grupo Ácido Ascórbico. El análisis histopatológico demuestra hallazgos de necrosis tubular aguda en el 100% del grupo control, mientras que en el grupo Ácido Ascórbico se obtuvo en un 50% de los sujetos únicamente detritos intraluminales. Conclusiones. La administración concomitante de Ácido Áscórbico con Gentamicina, disminuye significativamente el daño tubular renal, evidenciado en los valores de creatinina sérica, NAG, diuresis e histopatología renal.

  6. ANÁLISIS DE LOS EFECTOS INDUCIDOS POR UN PROGRAMA DE ENTRENAMIENTO PLIOMÉTRICO DE CUATRO SEMANAS DE DURACIÓN.

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    J. A. de Paz Fernández

    2010-10-01

    Full Text Available

     

    El objetivo de nuestro trabajo fue valorar las adaptaciones inducidas por un programa de entrenamiento pliométrico del tren inferior de 4 semanas de duración (12 sesiones, aplicado a 9 estudiantes de educación física (19.33±1.38 años, 74.89±6.89Kg, contando también con un grupo control (N=8. El grupo experimental mostró mejoras en la altura de salto vertical en diferentes test (SJ, CMJ y Abalakov, fuerza máxima isométrica de extensión de rodilla y potencia pico en cicloergómetro (test de Wingate, si bien ninguno de estos incrementos fue estadísticamente significativo. El grupo control no mostró mejoras en ningún test. El hecho de que los incrementos no alcanzasen significación estadística pudo deberse a la escasa duración del programa aplicado, en comparación con los programas citados en la literatura.
    PALABRAS CLAVE: Pliometría, Drop Jump, capacidad de salto, test de Wingate.

  7. Perfil sociodemográfico del aborto inducido

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    Cabezas-García Evelio

    1998-01-01

    Full Text Available Objetivo. Identificar características sociodemográficas y su fuerza de asociación con el aborto inducido del primer embarazo. Material y métodos. Se realizó un estudio analítico con la información de una encuesta realizada en el municipio Diez de Octubre, de la ciudad de La Habana, en Cuba, durante todo el año de 1991 y el primer semestre de 1992. La población de estudio se dividió en dos grupos de comparación: uno formado por las mujeres cuyo primer embarazo terminó en un aborto inducido y el otro constituido por aquellas cuyo embarazo llegó a término. De las variables estudiadas que mostraron diferencias estadísticamente significativas se obtuvieron las razones de momios crudas y ajustadas por la variable que se consideró como confusora: la edad. Para esta última fase del análisis se utilizó la regresión logística multivariada. Resultados. Las características sociodemográficas identificadas como factores de riesgo asociados al aborto inducido del primer embarazo fueron la edad menor de 24 años (aunque el riesgo se incrementa en las menores de 20 años y ser solteras o unidas. Conclusiones. El riesgo de recurrir a la práctica del aborto inducido en el primer embarazo es elevado en mujeres muy jóvenes que aún no han cumplido sus expectativas profesionales, laborales y relacionadas con el matrimonio. Estas razones parecen incompatibles con la maternidad en el grupo de mujeres estudiadas.

  8. Factores de riesgo de los trastornos hipertensivos inducidos por el embarazo en mujeres atendidas en una entidad de salud de Santa Marta

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    Gisela Esther González Ruiz

    2014-03-01

    Full Text Available Title: Risk factors hypertensive disorders induced pregnancy in women attended in a health company Santa Marta.Los trastornos hipertensivos del embarazo, son un problema de salud pública, la primera causa de muerte materna en países desarrollados y la tercera en países en desarrollo. Objetivo: Identificar los factores de riesgos que determinan la aparición de los trastornos hipertensivos, en mujeres embarazadas atendidas en una entidad de salud de Santa Marta, Colombia, en los meses de enero de 2011 a enero 2012. Materiales y métodos: estudio descriptivo, cuantitativo retrospectivo, realizado a un grupo de 51 pacientes gestantes que presentaron trastornos hipertensivos. Las técnicas de recolección de información se basaron en la revisión documental (historias clínicas y la aplicación de una encuesta previamente validada por expertos. A través de estos métodos se consignaron variables que permitieron identificar los factores en los trastornos hipertensivos de las gestantes. Resultados: la distribución por edad se ubicó en el rango 26 a 34 años (54.8%, los factores de riesgos presentes fueron: bajo peso (45.0%, no asistencia a controles prenatales (11,8%, multiparidad (56.9%, nivel socioeconómico medio-alto (45.1, antecedentes familiares relacionados con alteración hipertensiva de la madre (39.2%, antecedentes personales patológicos de infecciones urinarias (83.3% y consumo de alcohol (58.8%. Conclusiones: los factores de riesgo de antecedentes personales patológicos de infecciones urinarias se presentaron en un alto porcentaje (83,3%, el consumo de alcohol, multiparidad y antecedentes familiares, ocuparon un lugar importante; mientras que el nivel significativo de asistencia a controles prenatales, no evitó la aparición del trastorno hipertensivo. (DUAZARY 2013 No. 2, 119 - 126AbstractThe Hypertensive disorders of pregnancy are a public health problem, is the first cause of maternal death in the developed countries and the

  9. Cambios en la distribución de cultivos y producciones ganaderas en España inducidos por la nueva PAC

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    Júdez, Lucinio

    2008-12-01

    Full Text Available This paper analyses the impact on the Spanish agricultural sector of the CAP decoupling measures of direct payments for different crop areas and livestock.

    The study is based in the 2002 data from the Spanish Farm Accountancy Data Network (FADN and the simulated results are obtained with the mathematical programming model PROMAPA. The predicted changes in prices between the years 2002 and 2013 were those provided by the European Simulation Model (ESIM.

    The results obtained permit the comparison of the variation in the crop distribution and of the different types of livestock between the base year 2002 and the simulated year 2013 in the event of the implementation of a partial decoupling policy —as adopted in Spain in 2006— or a full decoupling policy which is under consideration at the moment.

    This paper also compares the variations which appear in the two types of decoupling with those that would be obtained in the even of a continuation of the Agenda 2000 measures.

    En este trabajo se analiza el impacto sobre el sector agrario español de las medidas de la Política Agraria Común de desacoplamiento de ayudas directas a las superficies sembradas de distintos cultivos y a las cabezas de ganado.

    El análisis se hace en base a los datos de 2002 de la Red Contable Nacional Agraria y a los resultados simulados para 2013 con el modelo de programación matemática PROMAPA, utilizando la predicción de variacion de precios entre 2002 y 2013 del modelo europeo de simulación ESIM.

    Los resultados obtenidos permiten comparar los cambios en la distribución de cultivos y de distintas categorías de ganado entre el año base 2002 y el año simulado, 2013, según se siga una política de desacoplamiento parcial, como la implantada en España en 2006, o una política de desacoplamiento total sobre la que se está reflexionando actualmente.

    En este trabajo se comparan, por otra

  10. Asma induzida pelo exercício: aspectos atuais e recomendações Asma inducido por el ejercicio: aspectos actuales y recomendaciones Exercise-induced asthma: current aspects and recommendations

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    Orlando Laitano

    2007-02-01

    Full Text Available OBJETIVO: Descrever os mecanismos da asma induzida pelo exercício (AIE, bem como os efeitos de diferentes tipos de treinamento físico na função pulmonar e nas capacidades aeróbia e anaeróbia. Destaca-se a importância de um diagnóstico correto mediante o teste de exercício e, no manejo, o uso de drogas beta-adrenérgicas e anticolinérgicas. FONTE DOS DADOS: Os artigos foram criteriosamente escolhidos utilizando as bases de dados PubMed e Scielo pelo ano de publicação e dando preferência a ensaios clínicos randomizados, com critérios de seleção da amostra bem definidos. SÍNTESE DOS DADOS: Os mecanismos para explicar a AIE permanecem sem conclusão, mas parece haver uma interação fisiológica entre as hipóteses aqui apresentadas. O uso de medicamentos e as freqüentes crises durante o exercício aparecem como fatores limitantes para a prática de exercícios físicos, conduzindo para um estilo de vida sedentário. CONCLUSÃO: Deve-se incentivar a prática de exercícios devidamente prescritos e minimizar as restrições aos sujeitos com AIE.OBJETIVO: Describir los mecanismos del asma inducido por el ejercicio (AIE, así como los efectos de diferentes tipos de entrenamiento físico sobre la función pulmonar y las capacidades aeróbica y anaeróbica. Se destaca la importancia de un diagnóstico correcto mediante el test de ejercicio y el manejo o uso de drogas beta-adrenérgicas y anticolinérgicas. FUENTES: Los artículos fueron cuidadosamente escogidos utilizando las bases de dados de PubMed y Scielo por el año de publicación, dando preferencia a ensayos clínicos randomizados, con criterios de selección de muestra bien definidos. SÍNTESES DE DATOS: Los mecanismos para explicar la AIE permanecen sin conclusión, pero parece haber una interacción fisiológica entre las hipótesis aquí presentadas. El uso de medicamentos y las frecuentes crisis durante el ejercicio aparecen como factores limitantes para la práctica de

  11. Actividad antioxidante de la melatonina sobre el hígado graso inducido por etionina en ratones Antioxidant activity of melatonin on fatty liver induced by ethionine in mice

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    SM Ferraro

    2008-01-01

    Full Text Available La finalidad de este estudio fue determinar la actividad antioxidante de la melatonina (MLT sobre el estrés oxidativo hepático (EOH inducido por etionina en ratones hembras y su efecto sobre la actividad de la enzima antioxidante glutatión peroxidasa (GPx. A 20 ratones se les administró MLT disuelta en etanol al 1% en dosis de 3 mg/kg p.v. vía intraperitoneal, durante 15 días y a los controles etanol 1%. Al día 13 a ambos grupos se indujo hígado graso por inyección de etionina 7,5 mg/0,02kg. Después de 48 horas de ayuno los animales fueron sacrificados y los hígados disecados. Una muestra se utilizó para análisis histopatólogico y en el sobrenadante obtenido de un homogeneizado se determinó malondialdehído (MDA, dienos conjugados (DC, triglicéridos (TG y la enzima GPx. Se realizó prueba "t" (P ≤ 0,05. Las concentraciones de TG, MDA y DC fueron menores en el grupo con MLT respecto al control (P The aim of this study was to determine the antioxidant activity of melatonin in female mice with ethionine-induced hepatic oxidative stress (HOS, and the effect of this hormone on the gluthatione peroxidase enzyme antioxidant activity. Twenty adult female NMRI mice were given intraperitoneally 3 mg/kg melatonin in 1% ethanol daily for 15 days, and 1% ethanol to the control group. On the 13th day of treatment, fatty liver was induced to both groups using 7.5 mg/0.02 kg ethionine. After 48 hours of food restriction, mice were sacrificed and livers dissected and sampled. Fixed tissue was used for hystopathologic analyses, and the supernatant obtained from an homogenated was used to determine concentrations of malondialdehyde (MDA, conjugate dienes (DC, triglycerides (TG and gluthatione peroxidase enzyme (GPx. Data were processed through SPSS vlO.O for Windows using the "t" test (P ≤ 0.05, and the results were expressed as X ± SD in mg TG, nm MDA and nm DC/mg proteins and per g of humid tissue and mU/mg proteins for GPx. Concentrations

  12. Alteraciones del desarrollo embrionario, poliaminas y estrés oxidativo inducidos por plaguicidas organofosforados en Rhinella Arenarum Alterations in embryonic development, polyamines and oxidative stress induced by organophosphates in Rhinella arenarum

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    Cecilia Inés Lascano

    2009-07-01

    Full Text Available Los plaguicidas organofosforados (OP son masivamente aplicados en el Alto Valle de Río Negro y Neuquén, afectando al ecosistema. Utilizamos un modelo embrionario de anfibios (Rhinella arenarum para estudiar mecanismos por los cuales OP como metilazinfos (MA y clorpirifos (CP podrían provocar teratogénesis. Los embriones fueron desarrollados en diferentes concentraciones de MA o CP hasta opérculo completo (OC, analizando: malformaciones, histología, glutatión reducido (GSH y enzimas antioxidantes, poliaminas, actividad de ornitina-decarboxilasa (ODC y proteínaquinasa- C (PKC. Ambos OP provocaron un incremento tiempo/concentración-dependiente de malformaciones, llegando a 100% de teratogénesis en estadios avanzados y a las mayores concentraciones, incluyendo: exogastrulación, curvaturas de aleta caudal, acortamiento axial, edema, y atrofia branquial. Se evidenció una condición de estrés oxidativo creciente: las enzimas GSH-dependientes (S-transferasa (GST, peroxidasa y reductasa fueron inducidas tempranamente a bajas concentraciones, pero inhibidas en el estadio de OC a altas concentraciones, junto con una caída significativa de GSH (62% para MA. MA incrementó significativamente (18X la actividad de ODC en OC, aumentando los niveles de putrescina (60% pero disminuyendo espermidina (56% y espermina (100%; CP disminuyó en estadios tempranos la actividad de ODC y niveles de poliaminas. La disminución de poliaminas podría deberse al incremento de degradación por poliamino-oxidasa, contribuyendo al estrés oxidativo inducido por OP. Esto causaría la disminución de GSH, y la activación de PKC en OC (55%, que participaría en el control positivo de GST y ODC. Finalmente, el estrés oxidativo y la disminución en los niveles de poliaminas podrían ser causantes de alteraciones del desarrollo embrionario.Organophosphate (OP pesticides are widely applied in the region of Alto Valle de Río Negro y Neuquén, affecting the ecosystem. We

  13. ¿CÓMO CAMBIA EL CEREBRO UN ABORTO INDUCIDO?

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    Natalia López Moratalla

    2012-01-01

    Full Text Available Estudios epidemiológicos cuantitativos muestran un riesgo entre moderado y muy alto de trastornos psiquiátricos tras el aborto inducido, especialmente de conductas adictivas e ideación de suicidio. Las mujeres que se habían sometido a un aborto experimentaron tienen un 81% más de riesgo de problemas de salud mental. Y cerca del 10% de la incidencia de problemas de salud mental se demostró que es atribuible al aborto. Siempre son más altos y sobre todo más duraderos que los que pudieran producirse por un aborto espontáneo. El embarazo no deseado no provoca trastornos y no se ha encontrado que el aborto inducido se asocie a mejor evolución de la salud mental, por lo que no puedan invocarse, sobre bases empíricas, razones de salud mental de la embarazada para inducir un aborto. Estudios de neuroimagen han mostrado que el trastorno de estrés postraumático, que sufren algunas mujeres tras el aborto voluntario, alterara las áreas cerebrales que regulan las emociones negativas, y de la memoria emocional. Los médicos deben transmitir el estado actual de ausencia de datos relacionados con los beneficios del aborto, además de informar detenidamente sobre los riesgos para la salud mental estadísticamente validados.

  14. Síndrome do coração partido (Síndrome de Takotsubo induzida por ecocardiograma de estresse com dobutamina Síndrome del corazón roto (síndrome de Tako-Tsubo inducido por ecocardiograma de esfuerzo con dobutamina Dobutamine stress echocardiography-induced broken heart syndrome (Takotsubo Syndrome

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    Francisco Juarez Cruz de Vasconcelos Filho

    2009-07-01

    Full Text Available Relatamos um caso de síndrome de Takotsubo induzida por ecocardiograma de estresse com dobutamina em uma paciente de 76 anos, hipertensa com queixas clínicas de dor precordial, em consulta cardiológica eletiva. Para exclusão de dor torácica de etiologia coronariana foi solicitado ecocardiograma de estresse com dobutamina. O exame foi realizado e, no pico do esforço máximo, o ecocardiograma mostrou acinesia apical com o eletrocardiograma mostrando supradesnivelamento do segmento ST em D1, AVL e V2. A paciente foi internada e submetida a coronariografia, que mostrou coronárias normais e VE com balonamento apical. A paciente evoluiu estável com reversão do quadro 21 dias após o quadro inicial.Relatamos un caso de síndrome de Tako-Tsubo inducido por ecocardiograma de esfuerzo con dobutamina en una paciente de 76 años, hipertensa con quejas clínicas de dolor precordial, en consulta cardiológica electiva. Para exclusión de dolor torácico de etiología coronaria se solicitó ecocardiograma de esfuerzo con dobutamina. El examen fue realizado, y en el pico de esfuerzo máximo, el ecocardiograma mostró acinesia apical con el electrocardiograma mostrando supradesnivel del segmento ST en D1, AVL y V2. La paciente fue internada y sometida a coronariografía, que mostró coronarias normales y VI con abombamiento apical. La paciente evolucionó estable con reversión del cuadro 21 días después del cuadro inicial.We report a case of dobutamine stress echocardiography-induced Takotsubo syndrome in a 76-year-old hypertensive patient with clinical complaints of chest pain in an elective visit to the cardiologist. Dobutamine-stress-echocardiography was requested to rule out chest pain of coronary origin. During the test, at peak exercise, echocardiogram showed apical akinesia and electrocardiogram showed ST-segment elevation in D1, AVL, and V2. The patient was hospitalized and underwent coronary angiography, which showed normal coronary arteries

  15. Cerebral toxoplasmosis in AIDS - computerized tomography evaluation; Toxoplasmose cerebral na SIDA - avaliacao por tomografia computadorizada

    Energy Technology Data Exchange (ETDEWEB)

    Alves, Regina Coeli Fonseca [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Hospital Universitario Antonio Pedro. Servico de Radiologia; Narchiori, Edson [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Radiologia

    1999-06-01

    Cerebral toxoplasmosis is a disease that affects many AIDS's patients. FOr this paper 46 patients with confirmed cases of cerebral toxoplasmosis who did a CT scan between March, 1994 and September, 1997 were examined. Single lesions were found in 28.3% of the patients. The lesions were more frequently detected in the basal ganglia and the frontal lobes. No lesion was larger than 4 cm. As regards the contrast enhancing of the lesions on a CT scan we observed that 54.5% of the lesions had a ring-like contrast enhancing, 36.4% had a nodular contrast enhancing and 6% had a heterogeneous form. After the 21st day of treatment we noticed an improvement in the aspect of the patients'lesions. The improvement of the lesions could be seen through a reduction of the edematous halo, a reduction of the lesion size and a modification in the contrast enhancing on the CT scan. The CT scan was an important method to demonstrate the lesions compatibility enhancing on the CT scan. The CT scan was an important method to demonstrate the lesions compatibility with cerebral toxoplasmosis, as well as to monitor these patients during treatment. (author)

  16. Sentimentos vivenciados por fisioterapeutas no atendimento a pessoas com paralisia cerebral Physiotherapist's feelings on attending people with cerebral palsy

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    Dinael Corrêa de Campos

    2009-08-01

    Full Text Available Considerando que os estudos sobre a relação profissional de saúde e cliente contribuíram para o surgimento da proposta do modelo humanizado de atendimento, esta pesquisa investigou os possíveis sentimentos de fisioterapeutas em relação ao atendimento de pessoas com paralisia cerebral, já que esta condição, a paralisia cerebral, é considerada sem cura pela medicina e com possibilidades de melhora diretamente vinculadas aos exercícios fisioterapêuticos. Utilizando um instrumento contendo perguntas abertas, foram realizadas entrevistas com fisioterapeutas que atendem aos casos com sequelas mais graves: ausência total da linguagem verbal e comprometimentos motores que levam os pacientes à situação de acamados. Mediante a análise de conteúdo, verificou-se que a paralisia cerebral é reconhecida pelos fisioterapeutas como um quadro neurológico e as limitações no alcance de resultados terapêuticos são vistas como normais. Assim, as mudanças, mesmo sendo reduzidas e obtidas em longo prazo, tornam o atendimento gratificante para os fisioterapeutas por representarem uma superação de desafios.Considering the studies about professional relation among health and clients contributted to arise the purposes about a humanized model of assistance. This research shows the physiotherapists' feelings on attending people with cerebral palsy, taking in accounting the cerebral palsy is presented by the medicine as a reverseless decease and having possibilities of changing entailed to the physiotherapy. By means of interviews and questionaries answered by physiotherapists, and using the contents of analysis, we can notice that the cerebral palsy is understood by the professional of physiotherapy like a neurological condition, so the limitations on reaching are noticed as normal. Thus, even the changes reduced in the long run, they make the attendance to be rewarding for the professional of physiotherapy, because these changes represent the

  17. El té verde en la quimioprevención in vivo del daño genotóxico inducido por metales cancerígenos (cromo [VI] Green tea and its role on chemoprevention in vivo of genotoxic damage induced by carcinogenic metals (Chromium [VI

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    M. C. García-Rodríguez

    2012-08-01

    Full Text Available Introducción: Debido a sus componentes antioxidantes, al consumo de infusiones de té verde se le ha asociado con efectos benéficos para la salud, ya que sus antioxidantes pueden jugar un papel importante en el riesgo y la patogénesis de algunas enfermedades crónicas, como algunos tipos de cáncer y enfermedades cardiovasculares. A su vez, se ha reportado que compuestos metálicos como los del Cr [VI] son carcinogénicos e inducen daño genotóxico mediante Estrés Oxidante (EOx. De ahí que, es posible que el té verde proteja del daño genotóxico inducido por estos compuestos. Objetivo: Se evaluó el efecto de la administración por vía oral del té verde sobre el daño genotóxico inducido por Cr [VI], mediante la cuantificación de micronúcleos (MN en eritrocitos policromáticos (EPC. Material y método: Ratones de la cepa CD-1 fueron divididos en forma aleatoria en los siguientes grupos: (i testigo, (ii tratados con té verde, (iii tratados con trióxido de cromo, (iv tratados con té verde y trióxido de cromo. El té verde se administró por sonda intragástrica cada 12 horas durante dos días (4 dosis de 0,25 ml de infusiones de 1,6 g/7,5 ml y ad libitum 5,6 ml/día durante 10 días de infusiones de 3,2 g/100 ml, mientras que, el trióxido de cromo se aplicó por vía intraperitoneal (20 mg/kg. Se obtuvieron muestras de sangre de la vena caudal, en las que se evaluó el número de MN en EPC a las 0, 24, 48 y 72 horas después de los tratamientos. Resultados: El grupo tratado con té verde no presentó cambios estadísticamente significativos en los promedios de MN. Por su parte, el grupo al que se le administró el trióxido de cromo mostró incrementos entre 4 y 8 MN, que resultaron estadísticamente significativos al compararlos con el grupo testigo, lo que corroboró el daño genotóxico. Cuando se combinaron los tratamientos del té verde y trióxido de cromo se observó una disminución en las frecuencias de MN del 31 y 62% a

  18. Biopsia cerebral a mano alzada guiada por tomografía Cerebral biopsy by a handfree procedure

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    Juan Carlos Arango

    1998-03-01

    Full Text Available Se presenta la experiencia del Servicio de Neurocirugía del Hospital Universitario San Vicente de Paúl con un procedimiento alternativo para realizar una biopsia cerebral, el cual se lleva a cabo a mano alzada y guiado por tomografía sin utilizar un marco estereotáxico. Se resalta su utilidad en los casos de lesiones supratentoriales y con tamaño mayor de 3 centímetros, en centros donde no se disponga de los métodos estereotáxicos tradicionales. We report the experience at the Neurosurgery Service, Saint Vincent's University Hospital (Medellín, Colombia with a hand free procedure for performing brain biopsies, without stereotactical frames. It is considered useful in supratentorial lesions larger than 3 cm, in places lacking stereotactical technology.

  19. Efectos de la administración de un inhibidor de la recaptación de serotonina, Sertralina, sobre los cambios inducidos por el estrés prenatal

    OpenAIRE

    Figueiredo Pereira de, Inês

    2016-01-01

    [ES] En las postrimerías del siglo pasado, se constató una vez más que las alteraciones causadas por estrés y ansiedad en la sociedad moderna, se encuentran entre los problemas de salud más comunes. Según la Organización Mundial de Salud (OMS), al menos el 25% de los adultos sufrirá alguna forma de trastornos por ansiedad en algún momento de su vida (Gordon y Hen, 2004; Anacker y cols., 2010), siendo las mujeres más susceptibles a este tipo de trastornos (Olff y cols., 2007). ...

  20. Diferentes estados de maduración de los frutos de Roystonea regia afectan su efecto sobre el aumento del tamaño de la próstata inducido por testosterona en ratas

    OpenAIRE

    Arruzazabala, María de Lourdes; Molina, Vivian; Carbajal, Daisy; Más, Rosa; González Canavaciolo, Víctor L.; Rodríguez, Eduardo J.; Marrero Delange, David

    2008-01-01

    En este trabajo se han comparado los efectos de extractos lipídicos obtenidos de los frutos de Roystonea regia de diferentes estados de maduración sobre la hiperplasia prostática inducida por testosterona en ratas. Frutos maduros, pintones y verdes fueron colectados y procesados para la obtención de extractos lipídicos, cuyo contenido de ácidos grasos fue analizado por cromatografía gaseosa. A medida que los frutos maduran la concentración de ácido láurico aumenta y el oleico disminuye, mient...

  1. Rinoliquorréia e hidrocefalia por gliose do aqueduto cerebral

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    Walter C. Pereira

    1967-03-01

    Full Text Available É relatado um caso de hidrocefalia tardia, determinada por gliose do aqueduto cerebral, complicada com rinoliquorréia. A fístula do líquido cefalorraqueano se estabeleceu em conseqüência da erosão da sela turca pelo assoalho do 3.° ventriculo hipertenso e dilatado, determinando comunicação entre a cavidade ventricular e o seio esfenoidal. O paciente foi operado, tendo a fístula sido ocluída satisfatoriamente; previamente foi feita derivação ventrículo-peritoneal para evitar recidiva da hipertensão do sistema ventricular.

  2. Efecto de la Movilización Neuromeníngea en la influencia de la fatigabilidad y daño muscular inducido por el ejercicio en jóvenes deportistas de alto rendimiento: estudio piloto

    OpenAIRE

    Sobrino Senovilla, Miguel

    2015-01-01

    Trabajo Fin de Grado (TFG) INTRODUCCIÓN : El Fútbol - Sala se caracteriza por su alta demanda fisiológica . Esto se ve acrecentado en el deporte de élite, donde a l ritmo inherente de la competición, le acompaña el componente psicol ógico del jugador. El alto nivel de exigencia en su conjunto, puede desembocar en una disminución del rendimiento deportivo, detrimento de las capacidades físicas y con ello condicionar la aparición de la le...

  3. Cambios morfológicos en la población somatotropa inducidos por terapia génica neonatal con el vector RAd-FTS en ratones nude

    OpenAIRE

    Rodolfo G Goya; Cónsole, Gloria Miriam; Martínez, E. V.; Bracamonte, María; Luna, Georgina; Reggiani, Paula Cecilia

    2010-01-01

    Se ha detectado un eje bidireccional timo-pituitario, hallándose receptores de GH en las células epiteliales tímicas. La GH estimularía la secreción de timulina, mientras que los niveles bajos de timulina circulante en período prenatal inducirían hipopituitarismo. El presente estudio tiene por objetivo: implementar una terapia génica mediante el vector adenoviral RAd-FTS en ratones inmunodeficientes, con el fin de prevenir cambios en la población somatotropa.

  4. Medición del daño genético inducido por el basuco en linfocitos humanos empleando la prueba de micronúcleos con citocalasina b

    OpenAIRE

    Ocampo AP.; Carvajal SM.; Hoyos LS.

    2011-01-01

    El bazuco es una mezcla compleja que se deriva del proceso de extracción de la cocaína. El frecuente consumo de bazuco constituye un problema de salud pública. La prueba de micronúcleos en linfocitos humanos de sangre periférica por bloqueo de la citocinesis con Citocalasina B, es más sensible y precisa para evaluar daño  cromosómico porque permite registrar micronúcleos originados de fragmentos de cromosomas o cromosomas enteros en células que se han dividido una sola vez. El objetivo del pr...

  5. Estudio de los efectos de agentes anticolinérgicos y de inhibidores de fosfodiesterasa-5 sobre la estructura pulmonar en un modelo experimental de enfermedad pulmonar obstructiva crónica inducido por humo de tabaco en el cobayo

    OpenAIRE

    Domínguez Fandos, David

    2015-01-01

    Tesi realitzada a l'Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) / Fundació Clinic per la Recerca Biomèdica La enfermedad pulmonar obstructiva crónica (EPOC) es una patología prevenible caracterizada por una limitación al flujo aéreo progresiva y no completamente reversible, disnea, producción de esputo y tos crónica. La obstrucción al flujo aéreo se asocia a un proceso inflamatorio crónico en la vía aérea y el parénquima pulmonar en respuesta a partículas nocivas...

  6. Efectos de los aceites de almendras dulces y de crisálida del gusano de la seda sobre el fotoenvejecimiento cutáneo inducido en ratones SKH1/CRL por radiación UV

    OpenAIRE

    Gil Ortega, Ana María

    2014-01-01

    La piel es el órgano más extenso del organismo y puede sufrir, además del envejecimiento cronológico, el denominado fotoenvejecimiento o envejecimiento cutáneo patológico. Está caracterizado por un envejecimiento cutáneo más extenso y sobre todo, de mayor gravedad, pues engloba la fotocarcinogénesis o presentación de cánceres cutáneos. Desde la Antigüedad, el hombre tuvo conciencia de la importancia del Sol en su vida, pero también de sus efectos indeseables. En la actualidad las sociedad...

  7. Aborto espontâneo e provocado: sentimentos vivenciados pelos homens Aborto espontáneo y inducido: sentimientos vivenciados por hombres Spontaneous and induced abortion: feelings experienced by men

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    Márcia Melo Laet Rodrigues

    2006-02-01

    Full Text Available A incorporação da perspectiva masculina na assistência em saúde reprodutiva é recomendada em nível mundial. Esta pesquisa teve como objetivo conhecer os sentimentos vivenciados por homens que compartilharam a experiência do aborto com suas parceiras. A análise da narrativa foi o método empregado. Narrativas de 17 homens foram analisadas para identificar os principais sentimentos relacionados à vivência. Os principais sentimentos associados ao aborto espontâneo estavam relacionados à angústia da perda e ao aborto provocado, à culpabilidade diante do ocorrido e suas conseqüências. Homens que compartilham da experiência do aborto requerem sensibilidade e envolvimento dos profissionais, suas principais demandas estavam relacionadas ao desejo do acolhimento, obtenção de suporte emocional e informações completas e precisas sobre o processo.La incorporación de la perspectiva masculina en la asistencia en salud reproductiva es recomendada en el ámbito mundial. El objetivo de esta investigación fue conocer los sentimientos vividos por hombres que compartieron la experiencia del aborto con sus compañeras. El método fue el análisis de la narrativa. Las narrativas de 17 hombres fueron analizadas para identificar los principales sentimientos relacionados a las vivencias. Los principales sentimientos relacionados al aborto espontáneo estaban relacionados a la angustia de la pérdida y frente al aborto provocado la culpabilidad delante de lo ocurrido y sus consecuencias. Hombres que compartieron la experiencia del aborto requieren sensibilidad y compromiso de los profesionales, las principales demandas estaban relacionadas al deseo de acogimiento, obtención del soporte emocional e informaciones completas y precisas sobre el proceso.The insertion of male perspective in reproductive health is an international recommendation. The aim of this research was to know the men's feelings related to the abortion shared with their partners

  8. Cambios inducidos por la implantación de olivos sobre las propiedades edáficas en el sur bonaerense Changes induced by tree olives implantation on soil properties in southern bonaerense

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    María del Carmen Blanco

    2005-12-01

    Full Text Available El reemplazo de la estepa graminosa nativa por montes de olivos (Olea europaea L. en pequeños sectores del sur pampeano afectados al cultivo de trigo ha introducido una modificación drástica en la vegetación como factor pedogenético activo. El impacto de este cambio se evaluó en el horizonte A de los suelos predominantes (Paleustolles Petrocalcicos bajo montes de olivos (LV2 implantados hace aproximadamente 50 a��os y se lo comparó con el ocasionado por la rotación tradicional trigo (LV3-vegetación natural (LV1. Se determinó: textura, densidad aparente (Da, pH, carbono orgánico (CO, nitrógeno total (Nt, fósforo disponible (Pd, CIC, bases intercambiables y, además, se estudió la organización micromorfológica. El efecto del cambio de vegetación es notable en las tres situaciones comparadas, no obstante, las variables químicas y la micropedología no reflejan disminución de la calidad del suelo a partir de la introducción de olivos.In small sectors of the southern Pampean region affected by wheat cultivation, the native grassland steppe has been replaced by Olea europaea L. mounts, which introduced a drastic modification of vegetation as an active factor of pedogenesis. The impact of this change was evaluated in the A horizons of the predominant soils (Petrocalcic Paleustolls under olives mounts of approximately 50 years (LV2 and has been compared to that derived after the traditional rotation wheat (LV3-native vegetation (LV1. Chemical analyses were performed to analyze the variables commonly used in the evaluation of soil fertility: bulk density (Da, texture, pH, organic carbon (CO, total nitrogen (Nt, available phosphorous (Pd, CIC, exchangeable bases. Moreover, a micromorphological study was done. Increments of 90% magnitude order in CO content, 70% in Nt and >100% in Pd were detected under olive trees cultivation related to a high biomass of olive trees and grass vegetation in the epipedon and to the intense

  9. Efectos "in vivo" de Metformina sobre las alteraciones de la microarquitectura sea asociadas al Sndrome Metablico inducido por fructosa en ratas In vivo effects of Metformin on the alterations of bone micro-architecture associated with fructose-induced Metabolic Syndrome in rats

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    J.I Felice

    2011-10-01

    Full Text Available El Sndrome Metablico (SM se ha asociado recientemente con una disminucin en la densidad mineral sea, y con un aumento en la incidencia de fracturas osteoporticas. Recientemente encontramos que la Metformina por va oral en ratas, promueve la diferenciacin osteognica de clulas progenitoras de mdula sea e incrementa la reparacin de lesiones seas. En este trabajo evaluamos los efectos del SM inducido por Fructosa sobre la microarquitectura sea en ratas, y la modulacin de estos efectos por Metformina administrada en forma oral. Utilizamos ratas Sprague Dawley macho jvenes: C (control sin tratamiento, C+M (100mg/kg/da Metformina en el agua de bebida, F (10 % Fructosa en el agua de bebida y F+M (Fructosa+Metformina en el agua de bebida. Los tratamientos se continuaron por 3 semanas luego de lo cual se tomaron muestras de sangre, previas al sacrificio de los animales. Se disecaron los fmures para evaluacin histomorfomtrica de la microarquitectura metafisaria por tincin con Hematoxilina-Eosina (H-E. Se observ un incremento en la glucemia y trigliceridemia en el grupo F versus el C, compatible con el desarrollo de SM. El anlisis de las metfisis femorales mostr un aumento en la densidad osteoctica trabecular para el grupo C+M (118 % del control, pSeveral clinical studies have demonstrated that the Metabolic Syndrome (MS is associated with a decrease in bone mineral density, and with an increased risk for non-vertebral osteoporotic fractures. We have recently found that orally administered Metformin induces osteogenic effects in rats, promoting osteoblastic differentiation of bone marrow progenitor cells and increasing the repair of bone lesions. In the present work we have evaluated the effects of Fructose-induced MS on bone micro-architecture in rats, and the possible modulation of these effects by orally administered Metformin. We utilized young male Sprague-Dawley rats, divided into four groups: C (non-treated controls; C+M (100 mg/kg/day of Metformin

  10. Agrandamiento gingival inducido por nifedipina.Reporte de un caso

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    Antonio José Díaz Caballero

    2013-10-01

    Full Text Available ResumenEs bien conocido que el tratamiento con diversos tipos de medicamentos puede producir en las encías un crecimiento de este tejido. Se reporta que medicamentos tales como los bloqueadores de los canales de calcio, inmunosupresores, anticonvulsivantes pueden expresar esos efectos laterales. La nifedipina es la que principalmente se reporta que produce agrandamientos gingivales, al ser utilizada durante tratamientos largos para trastornos cardiovasculares, angina de pecho e hipertensión. Se presenta un caso de paciente varón de 60 años de edad, hipertenso, tratado con nifedipina, con agrandamientos gingivales. Se realiza fase higiénica y terapia quirúrgica con electro cirugía. La evolución y predecibilidad fueron favorables. (Duazary 2009 I; 51-55AbstractIt is well known that chronic medication with various drugs may cause gingival overgrowth. It has been reported that gingival overgrowth is induced by drugs such as calcium channel blockers and immunosuppressants. Nifedipine is most frequently reported to induce gingival overgrowth during long-term treatment of cardiovascular disorders such as hypertension and angina pectoris. A case of a 60 year old male patient with hypertension treated with nifedipine is presented. Electrosurgery treatment was performed; the evolution and prediction are favorable.Key Words: Nifedipine; Gingival Overgrowth; Calcium Cannel Blocker.

  11. Sincretismo mitológico inducido por contacto

    NARCIS (Netherlands)

    J. Gómez Rendón

    2013-01-01

    The present study explores an almost untrodden field in the structuralist mythemic analysis, according to which a myth is a narrative matrix that may and should be read along a diachronic axis. This perspective highlights socio-historical aspects of mythopoesis as mirrored on the matter and pattern

  12. Mifepristone inhibits MPA-and FGF2-induced mammary tumor growth but not FGF2-induced mammary hyperplasia La mifepristona inhibe el crecimiento de carcinomas mamarios inducidos por MPA o por FGF2 pero no las hiperplasias mamarias inducidas por FGF2

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    Juan P. Cerliani

    2010-12-01

    Full Text Available We have previously demonstrated a crosstalk between fibroblast growth factor 2 (FGF2 and progestins inducing experimental breast cancer growth. The aim of the present study was to compare the effects of FGF2 and of medroxyprogesterone acetate (MPA on the mouse mammary glands and to investigate whether the antiprogestin RU486 was able to reverse the MPA- or FGF2-induced effects on both, mammary gland and tumor growth. We demonstrate that FGF2 administered locally induced an intraductal hyperplasia that was not reverted by RU486, suggesting that FGF2-induced effects are progesterone receptor (PR-independent. However, MPA-induced paraductal hyperplasia was reverted by RU486 and a partial agonistic effect was observed in RU486-treated glands. Using C4-HD tumors which only grow in the presence of MPA, we showed that FGF2 administered intratumorally was able to stimulate tumor growth as MPA. The histology of FGF2-treated tumors showed different degrees of gland differentiation. RU486 inhibited both, MPA or FGF2 induced tumor growth. However, only complete regression was observed in MPA-treated tumors. Our results support the hypothesis that stromal FGF2 activates PR inducing hormone independent tumor growth.Hemos demostrado previamente que la vía de señalización del factor de crecimiento fibroblástico 2 (FGF2 interactúa con la vía de los receptores de progesterona (RP induciendo el crecimiento del cáncer de mama experimental, y hemos postulado que el FGF2 estromal activaría los RP en los tumores hormono independientes. El objetivo de este trabajo es comparar los efectos del FGF2 y del acetato de medroxiprogesterona (MPA en la glándula mamaria de ratón e investigar si el antiprogestágeno RU486 induce la regresión del tumor hormono dependiente C4-HD que crece con MPA o con la administración intratumoral de FGF2. Demostramos que la administración diaria local de FGF2 induce una hiperplasia intraductal mamaria que no es revertida por el

  13. Un caso de infeccion humana por cisticerco racemoso cerebral de localizacion parenquimatosa en Valdivia, Chile A case of human cerebral infection by parenchymal racemose cysticercus in Valdivia, Chile

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    Eduardo Ortega

    1991-06-01

    Full Text Available Se presenta un caso clínico de infección por cisticerco racemoso cerebral de localización parenquimatosa en un paciente de la ciudad de Valdivia (Chile cuyo diagnóstico definitivo se efectuó a través del estudio morfológico del parásito. Se discute brevemente la escasa frecuencia de la localización parenquimatosa del cisticerco racemoso, así como su diagnóstico diferencial con otros estados larvarios de cestodos que desarrollan en el sistema nervioso.A clinical case of cerebral infection by parenchymal racemose cysticercus, diagnosed by means of morphological characteristics in a patient of Valdivia city is described. The rare frequency of parenquimal location of racemose cysticercus as well as its differential diagnosis with other larval stages of cestodes that develop in the brain and its treatment are discussed.

  14. Efeito da administração do atracúrio sobre a recuperação do bloqueio neuromuscular induzido pelo pancurônio Efecto de la administración del atracúrio sobre la recuperación del bloqueo neuromuscular inducido por el pancuronio Effect of atracurium on pancuronium-induced neuromuscular block recovery

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    Luís Fernando Rodrigues Maria

    2004-06-01

    diminuição de 20% no tempo de recuperação total.JUSTIFICATIVA Y OBJETIVOS: Frecuentemente en cirugías abdominales, en la fase de cerramiento de la pared, hay necesidad de dosis adicionales de bloqueador neuromuscular. El objetivo de este estudio fue analizar, en la vigencia de recuperación parcial del bloqueo neuromuscular inducido por el pancuronio, el efecto de la administración de dosis complementares de atracúrio sobre la recuperación espontanea del bloqueo neuromuscular. MÉTODO: Fueron estudiados 30 pacientes, divididos en dos grupos, 14 pacientes formaron el grupo pancuronio y 16 pacientes, el grupo atracúrio. La función neuromuscular fue monitorizada de forma continua por acelerometria del músculo aductor del pulgar, utilizando la secuencia de cuatro estímulos (SQE, a través de la estimulación supramáxima del nervio ulnar. La inducción de la anestesia fue hecha con propofol, fentanil, pancuronio 0,08 mg.kg-1 y la manutención con N2O 60% en oxígeno e isoflurano en la concentración expirada de 0,5%. Cuando la primera contracción de la secuencia de cuatro estímulos (T1 recuperó 25%, el grupo pancuronio recibió pancuronio 0,025 mg.kg-1 y el grupo atracúrio, 0,20 mg.kg-1 de atracúrio. Después de la dosis complementar fueron anotados los tiempos para recuperación espontanea de T1 igual a 10%, 25%, 75%, del índice de recuperación (IR25-75% y de la relación T4/T1 igual a 0,8. RESULTADOS: Los tiempos de recuperación espontanea después de la dosis complementar de pancuronio o atracúrio no divergieron cuando evaluados por la recuperación de T1 en 10% (45,00 ± 15,50 vs 49,69 ± 9,41, 25% (61,64 ± 18,58 vs 64,25 ± 12,51 y 75% (94,00 ± 28,52 vs 84,69 ± 16,50. El IR25-75% (32,36 ± 13,76 vs 20,44 ± 9,24 y el tiempo de recuperación de la relación T4/T1 = 0,8 (176,86 ± 29,57 vs 141,50 ± 29,57 fueron mayores en el grupo en que la complementación fue realizada con pancuronio. CONCLUSIONES: En las condiciones de este estudio, la

  15. Cerebral aspergillosis due to Aspergillus fumigatus in AIDS patient: first culture - proven case reported in Brazil Aspergilosis cerebral causada por Aspergillus fumigatus en paciente con SIDA: primer reporte de caso demostrado por cultivo en Brasil

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    José E. Vidal

    2005-06-01

    Full Text Available Cerebral aspergillosis is a rare cause of brain expansive lesion in AIDS patients. We report the first culture-proven case of brain abscess due to Aspergillus fumigatus in a Brazilian AIDS patient. The patient, a 26 year-old male with human immunodeficiency virus (HIV infection and history of pulmonary tuberculosis and cerebral toxoplasmosis, had fever, cough, dyspnea, and two episodes of seizures. The brain computerized tomography (CT showed a bi-parietal and parasagittal hypodense lesion with peripheral enhancement, and significant mass effect. There was started anti-Toxoplasma treatment. Three weeks later, the patient presented mental confusion, and a new brain CT evidenced increase in the lesion. He underwent brain biopsy, draining 10 mL of purulent material. The direct mycological examination revealed septated and hyaline hyphae. There was started amphotericin B deoxycholate. The culture of the material demonstrated presence of the Aspergillus fumigatus. The following two months, the patient was submitted to three surgeries, with insertion of drainage catheter and administration of amphotericin B intralesional. Three months after hospital admission, his neurological condition suffered discrete changes. However, he died due to intrahospital pneumonia. Brain abscess caused by Aspergillus fumigatus must be considered in the differential diagnosis of the brain expansive lesions in AIDS patients in Brazil.La aspergilosis cerebral es una causa rara de lesión expansiva cerebral en pacientes con SIDA. Presentamos el primer reporte de un absceso cerebral causado por Aspergillus fumigatus en un paciente brasileño con SIDA. El paciente, de 26 años de edad, presentaba antecedentes de infección por el virus de la inmunodeficiencia humana (VIH, tuberculosis pulmonar y toxoplasmosis cerebral. Manifestó fiebre, tos, disnea y dos episódios de convulsiones. La tomografía computadorizada (TC demostró una lesión hipodensa parasagital y bi-parietal con

  16. Perfil sociodemográfico del aborto inducido Sociodemographic profile of induced abortion

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    Evelio Cabezas-García

    1998-05-01

    Full Text Available Objetivo. Identificar características sociodemográficas y su fuerza de asociación con el aborto inducido del primer embarazo. Material y métodos. Se realizó un estudio analítico con la información de una encuesta realizada en el municipio Diez de Octubre, de la ciudad de La Habana, en Cuba, durante todo el año de 1991 y el primer semestre de 1992. La población de estudio se dividió en dos grupos de comparación: uno formado por las mujeres cuyo primer embarazo terminó en un aborto inducido y el otro constituido por aquellas cuyo embarazo llegó a término. De las variables estudiadas que mostraron diferencias estadísticamente significativas se obtuvieron las razones de momios crudas y ajustadas por la variable que se consideró como confusora: la edad. Para esta última fase del análisis se utilizó la regresión logística multivariada. Resultados. Las características sociodemográficas identificadas como factores de riesgo asociados al aborto inducido del primer embarazo fueron la edad menor de 24 años (aunque el riesgo se incrementa en las menores de 20 años y ser solteras o unidas. Conclusiones. El riesgo de recurrir a la práctica del aborto inducido en el primer embarazo es elevado en mujeres muy jóvenes que aún no han cumplido sus expectativas profesionales, laborales y relacionadas con el matrimonio. Estas razones parecen incompatibles con la maternidad en el grupo de mujeres estudiadas.Objective. To identify sociodemographic characteristics associated with induced abortion of the first pregnancy and quantify the strength of association between them. Material and methods. Data were gathered from a survey conducted in the district of Diez de Octubre, Havana, Cuba throughout 1991 and the beginning of 1992. The study population was divided into two comparable groups: one group of women whose first pregnancy terminated in induced abortion and a second group of women whose pregnancy terminated in childbirth. For the

  17. Sincronización de la ovulación y el ciclo inducido por el efecto "macho" mediante la administración de progesterona por vía intravaginal en cabras en período de anestro estacional

    OpenAIRE

    Mogedas Moreno, María

    2016-01-01

    Algunos de los métodos alternativos a los tratamientos hormonales clásicos utilizando progestágenos y eCG, para la inducción y sincronización del celo y la ovulación, unido a la inseminación artificial (IA) a tiempo fijo en ganado caprino, están basados como el IMA.PRO2® en el estímulo por la presencia de los machos (efecto macho) y la sincronización de la ovulación inducida mediante prostaglandina F2α o sus análogos. En estos métodos, la administración de una dosis baja de progesterona o pro...

  18. Muerte súbita por embolia cerebral de mixoma de la aurícula izquierda Sudden death due to cerebral embolism from a left atrial myxoma

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    B. Aguilera

    2011-09-01

    Full Text Available El mixoma es el tumor cardiaco primario más frecuente. Puede manifestarse con síntomas cardiacos, síntomas generales y embolismo tumoral sistémico. Aunque es un tumor benigno, las embolizaciones, especialmente las cerebrales, pueden ocasionar graves complicaciones neurológicas, de ahí que esté indicada su resección quirúrgica. Presentamos el caso de un varón de 47 años que, en ausencia de síntomas previos, presenta síncope mientras mantenía relación sexual, falleciendo a las pocas horas. En la autopsia se constató en la aurícula izquierda, un tumor pediculado y gelatinoso de 1 cm de diámetro adherido al tabique interauricular, y en la arteria carótida interna derecha, un trombo oclusivo. Al estudio histológico, el tumor presentaba la morfología típica del mixoma cardiaco recubierto por trombo de fibrina y la oclusión arterial estaba ocasionada por émbolo tumoral y trombo de fibrina, hallazgos que explicaron el cuadro clínico.Myxoma is the most common primary tumor of the heart. Clinical manifestations are due to cardiac disturbance, systemic embolism and constitutional symptoms. Although it is a benign tumor, embolism, especially cerebral ones, can produce neurological complications. Surgical treatment of the myxomas is indicated to prevent cerebral complications. We present the case of a previously asymptomatic 47 years-old man who suffer syncope during sexual intercourse, dying few hours later without recover conscientious. At autopsy, in the left atria there was a gelatinous tumor, 1cm length, attached to the interatrial septum and the internal right carotid artery was occluded by a thrombus. Microscopically, the tumor demonstrated the characteristic histological findings of cardiac myxoma covered by fibrinous thrombus and, the carotid artery was occluded by a tumoral embolism.

  19. ¿CÓMO CAMBIA EL CEREBRO UN ABORTO INDUCIDO?

    OpenAIRE

    Natalia López Moratalla

    2012-01-01

    Estudios epidemiológicos cuantitativos muestran un riesgo entre moderado y muy alto de trastornos psiquiátricos tras el aborto inducido, especialmente de conductas adictivas e ideación de suicidio. Las mujeres que se habían sometido a un aborto experimentaron tienen un 81% más de riesgo de problemas de salud mental. Y cerca del 10% de la incidencia de problemas de salud mental se demostró que es atribuible al aborto. Siempre son más altos y sobre todo más duraderos que los que pudieran ...

  20. Efectos inducidos por Ruta graveolens L., Cnidoscolus chayamansa McVaugh y Citrus aurantium L. sobre los niveles de glucosa, colesterol y triacilglicéridos en un modelo de rata diabética Efeitos induzidos por Ruta graveolens L., Rutaceae, Cnidoscolus chayamansa McVaugh, Euphorbiaceae, e Citrus aurantium L., Rutaceae, nos níveis de glucose, colesterol e triacilglicerídeos num modelo do rato diabético Induced effects by Ruta graveolens L., Rutaceae, Cnidoscolus chayamansa McVaugh, Euphorbiaceae, and Citrus aurantium L., Rutaceae, on glucose, cholesterol and triacylglycerides levels in a diabetic rat model

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    Lauro Figueroa-Valverde

    2009-12-01

    Full Text Available Varias plantas con propiedades hipoglucemicas se han utilizado en medicina popular y sistemas curativos tradicionales en todo el mundo. El propósito de este trabajo fue evaluar los efectos inducidos por Ruta graveolens L., Rutaceae, Cnidoscolus chayamansa McVaugh, Euphorbiaceae, y Citrus aurantium L., Rutaceae, en un modelo de rata diabética, a la que se le cuantificaron los niveles de glucosa cada 24 horas por un mes después de la administración gástrica del extracto de las plantas. Además, el colesterol y los triglicéridos fueron evaluados usando técnicas enzimáticas. Los resultados mostraron que la administración de Cnidoscolus chayamansa a dosis de 0.5 a 1.5 g/kg induce un aumento hipoglucemico ( 200 mg/dL. Otros resultados, mostraron que Citrus aurantium ejerce cambios en la concentración de triacilglicéridos (158-172 mg/dL y colesterol (120-128 mg/dL. Finalmente, la administración de Ruta graveolens a dosis de 0.5 g/kg induce un efecto hipoglucemico (Diversas plantas com propriedades hipoglicêmicas foram usadas na medicina popular e em sistemas tradicionais de curas em torno do mundo. A finalidade deste trabalho foi avaliar os efeitos induzidos por Ruta graveolens L, Rutaceae, Cnidoscolus chayamansa McVaugh, Euphorbiaceae, e Citrus aurantium L., Rutaceae, em modelo do rato diabético onde níveis da glucose foram determinados a cada 24 h em um mês antes da administração gástrica do extrato das plantas. Colesterol e triacilglicerídeos foram avaliados usando técnicas enzimáticas. Os resultados mostraram que a administração de Cnidoscolus chayamansa a dose de 0,5 a 1,5 g/kg induz um aumento hipoglicêmico ( 200 mg/dL. Outros resultados, mostraram que Citrus aurantium exerce mudanças na concentração de triacilglicerídeos (158-172 mg/dL e colesterol (120-128 mg/dL. Finalmente, a administração de Ruta graveolens na dose de 0.5 g/kg induziu um efeito hipoglicêmico (Several plants with hypoglycemic properties have

  1. Mineral and/or milk supplementation of fruit beverages helps in the prevention of H2O2-induced oxidative stress in Caco-2 cells La adición de minerales y/o leche a bebidas a base de zumo de frutas ayuda en la prevención del estrés oxidativo inducido por H2O2 en celulas Caco-2

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    A. Cilla

    2011-06-01

    aporte de numerosos compuestos bioactivos que pueden actuar de forma aditiva o sinérgica frente al estrés oxidativo. Objetivos: Evaluar si la adición de hierro, cinc y leche a las bebidas a base de zumo de frutas no afecta al efecto cito-protector frente al daño oxidativo en células Caco-2 a través de la inducción de enzimas del ciclo del GSH y la preservación de la progresión del ciclo celular, en comparación con la bebida a base de zumo de frutas no suplementada. Métodos: Las células Caco-2 se incubaron 24 h con las fracciones bioaccesibles (FB de ocho bebidas a base de zumo de frutas con/sin hierro y/o cinc y/o leche, y se sometieron a estrés oxidativo con H2O2 (5 mmol L-1-2 h. Se determinó la actividad enzimática mitocondrial (test MTT, la actividad de las enzimas GSH-Rd y GSH-Px, la progresión del ciclo celular y la actividad de la enzima caspasa-3. Resultados y discusión: Las bebidas a base de zumo de frutas previnieron del efecto perjudicial del H2O2 sobre la viabilidad celular, con casi todas las muestras alcanzando los niveles basales del control. Sólo la adición independiente de hierro o cinc con/sin leche ejerció efectos positivos sobre la actividad de la enzima GSH-Rd. Por otra parte, ambos minerales con leche proporcionaron una mejor preservación en la actividad de la enzima GSH-Px. Todas las muestras previnieron el descenso en la fase G1 del ciclo celular inducido por el H2O2, excepto la muestra adicionada de hierro, pero ninguna de ellas evitó el incremento en la fase subG1 del ciclo celular. Sin embargo, este hecho no estuvo asociado con la actividad de la enzima caspasa-3, con un probable efecto positivo del cinc sobre este parámetro. Conclusión: La adición de minerales y/o leche a las bebidas a base de zumo de frutas ayuda en la prevención de estrés oxidativo en células Caco-2 mediante el mantenimiento de la viabilidad celular, activación de enzimas del ciclo del GSH, preservación de la progresión del ciclo celular e

  2. Infarto cerebral secundario a trombosis de la carótida interna por traumatismo cervical Cerebral infarction secondary to internal carotid thrombosis following cervical trauma

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    A. Rico

    2011-06-01

    Full Text Available Se presenta el caso de una trombosis postraumática de la arteria carótida interna en un varón de 33 años, tras recibir un golpe con un balón en el cuello. La muerte se produjo 10 días después del golpe como consecuencia de un cuadro de hipertensión intracraneal y herniación cerebral secundaria a infarto isquémico extenso que afectaba a todo el territorio de la arteria cerebral media derecha, tanto superficial como profundo.In this paper, a case of post-traumatic thrombosis in the internal carotid artery after a blow with a ball in the neck of a 33-year-old male is presented. The death came 10 days after the coup as a result of intracranial hypertension and cerebral herniation secondary to ischemic infarction affecting the entire territory of the middle right cerebral artery, both superficial and profound. Macroscopic and microscopic findings that largely explain the mechanism of vascular injury with intimal dissection in the proximity of an atheroma plaque located above the carotid bifurcation are discussed.

  3. Tuberculoma cerebral Cerebral tuberculoma

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    ELIZABETH CLARA BARROSO; TÂNIA REGINA BRÍGIDO DE OLIVEIRA; ANA MARIA DANTAS DO AMARAL; VALÉRIA GÓES FERREIRA PINHEIRO; ANA LÚCIA DE OLIVEIRA SOUSA

    2002-01-01

    Relata-se o caso de paciente com crises convulsivas de início recente. A tomografia computadorizada cerebral evidenciou imagem sugestiva de lesão expansiva metastática frontoparietal direita. A investigação de tumor primário ou outra doença foi negativa e o exame histopatológico do tecido cerebral diagnosticou tuberculoma. As convulsões foram controladas com a associação de hidantoína 300mg/dia ao esquema específico, utilizado por 18 meses. A tuberculose do sistema nervoso central representa ...

  4. Análisis de los cambios en la expresión génica inducidos por el tratamiento con pseudoterosina en la línea celular de cáncer de mama MDA-MB231

    OpenAIRE

    Siabatto Fernandez, Helbert David

    2015-01-01

    De acuerdo a cifras publicadas por la Organización Mundial de la Salud, el cáncer de mama es una de las patologías con mayor porcentaje de mortalidad e incidencia en las mujeres, y en este sentido es necesario el desarrollo de nuevas alternativas para su tratamiento (Saucedo, 2013). Hoy en día están en uso clínico al menos 121 fármacos antineoplásicos que no cubren todas las necesidades de tratamiento, y es pertinente continuar investigando nuevas moléculas activas que presenten mayor efecti...

  5. Infarto cerebral hemorrágico por embolización de un trombo mural cardíaco Hemorrhagic cerebral infarction due to embolization of a mural thrombus within the right ventricle

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    R. Marín

    2008-04-01

    Full Text Available Las enfermedades cerebrovasculares son consecuencia de una alteración en la circulación cerebral. Su forma más distintiva de presentación es el ictus, entendido como un déficit neurológico focal de instauración brusca y evolución rápida. Un infarto cerebral de origen oclusivo puede deberse bien a una trombosis in situ o bien a una embolia procedente de un foco distante. En las embolias cerebrales la causa principal son los trombos murales cardiacos y el área encefálica afectada con mayor frecuencia es el territorio irrigado por la arteria cerebral media. Presentamos el caso de una mujer de 81 años, con antecedentes de Hepatitis C, cardiopatía hipertensiva y fibrilación auricular crónica, que sufrió una fractura de cadera consecutiva a una caída accidental. Durante el ingreso hospitalario comenzó un cuadro de deterioro neurológico progresivo que no llegó a ser filiado, falleciendo 9 días después. En la autopsia médico-forense se encontró un infarto cerebral hemorrágico en el territorio de la arteria cerebral media izquierda. Dado que las arterias del Polígono de Willis eran permeables y ante la presencia de trombos vitales adheridos a la pared del ventrículo derecho, se estimó como causa más probable del accidente vasculocerebral la embolización de uno de dichos trombos.Cerebrovascular diseases are due to a disturbance in cerebral blood flow. The most frequent way of presentation is stroke, defined as a sudden and focal neurological impairment with rapid evolution. Cerebral infarction of occlusive origin can be secondary to in situ thrombosis or to embolism from a distal focus. Mural thrombi are the main cause of brain embolism and the middle cerebral artery territory is the most likely affected brain area. We report the case of an 81 year-old woman, with antecedents of Hepatitis C, hypertensive cardiopathy and chronic atrial fibrillation, who suffered a hip fracture due to an accidental fall. A progressive

  6. Beneficial effect of Berberis buxifolia Lam, Ziziphus mistol Griseb and Prosopis alba extracts on oxidative stress induced by chloramphenicol Efecto benéfico de extractos de Berberis buxifolia Lam, Zizyphus mistol Griseb y Prosopis alba sobre el estrés oxidativo inducido por cloramfenicol

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    Claudia Albrecht

    2010-02-01

    Full Text Available The chemiluminescence of luminol, a measure of oxidative stress, increased immediately as a consequence of reactive oxygen species (ROS stimulated by this antibiotic. The effect of Ch was dose dependent with maximum stimulus at 8 mg/ml (Vmax; above this concentration the cells began to reduce the production of ROS. The oxidative injury of Ch was counteracted by water extracts of Berberis buxifolia lam, Zizyphus mistol Griseb and Prosopis alba, indigenous fruits from Argentina. The relatively light units (RLU emitted decreased immediately as a consequence of a protective effect exerted by the extracts of these fruit extracts on blood cells. The three indigenous fruit extracts reduced to a different extent the oxidative injury caused by Ch. B.buxifolia lam exhibited the highest antioxidant capacity followed by Z.mistol Griseb. Water extracts of both fruit extracts were the most effective against the oxidative stress, while P.alba presented better antioxidant capacity in the ethanolic fraction obtained. Hexane extracts showed low protective action on blood cells, with little reduction of area under curve (AUC of RLU plotted versus time. Leukocytes remained viable in blood samples incubated for 3h with Ch and water extracts of B. buxifolia lam or Z. mistol Griseb (97.1% and 92.5% viability by Trypan blue exclusion, respectively; whereas with Ch only the cells were stressed and viability decreased to 30%. The three fruit extracts protected the viability of leukocytes in parallel with the decrease of ROS. Erythrocytes were not lysed in the presence of Ch.Se estudió el efecto antioxidante de tres extractos de frutas autóctonas, Berberis buxifolia lam (michay, Zizyphus mistol Griseb (mistol and Prosopis alba (algarrobo. Las células sanguíneas humanas sufrieron estrés oxidativo por acción de cloramfenicol (Ch, con un aumento inmediato de especies reactivas del oxígeno (ERO, que fue determinado por quimioluminiscencia con luminol. La respuesta fue

  7. Respuesta de anticuerpos inducidos por la vacuna antimeningocócica cubana VA-MENGOC-BC® frente a la cepa de Neisseria meningitidis B:4:P1.19,15 en adolescentes después de 12 años de inmunizados

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    María A. Camaraza

    2006-12-01

    Full Text Available Se estudió la respuesta de anticuerpos inducida por la vacuna antimeningocócica cubana VA-MENGOC-BC® contra la cepa de Neisseria meningitidis B:4:P1.19,15 mediante el Ensayo Bactericida del Suero (EBS y ELISA de tipo indirecto, para medir anticuerpos contra vesículas de membrana externa (VME de N. meningitidis B a 184 adolescentes de un politécnico de Ciego de Ávila que fueron inmunizados en campañas masivas 12 años antes. Se realizaron extracciones de sangre antes de aplicar la primera dosis (T0, 4 semanas después de ésta (T1 y 4 semanas después de la segunda dosis (T2. Transcurridos 12 años de esta vacunación el 42% de los adolescentes presentó títulos bactericidas ≥ 1:4 frente a la cepa homóloga (B:4:P1.19,15 y el 98% mostró anticuerpos detectables contra las VME. En el EBS; el porcentaje de seroconversión T1/T0 fue del 57% y T2/T0 del 60%. Mediante ELISA la seroconversión fue del 59% y 54%, respectivamente, por lo que se demostró que la aplicación de una sola dosis después de 12 años indujo una respuesta inmune importante que puede sugerir una respuesta anamnésica.

  8. Clínicas del dolor y cuidados paliativos en México: manejo del estreñimiento inducido por opiáceos. Conclusiones de un grupo de expertos Pain clinics and palliative care in Mexico: management of opioid-induced constipation. Conclusions of an expert group

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    J.A. Flores Cantisani

    2009-12-01

    Full Text Available A finales de septiembre de 2008, 15 líderes de opinión en el tratamiento del dolor y los cuidados paliativos de México se reunieron en la ciudad de México con el objetivo de elaborar una guía clínica acerca del uso de opiáceos y sus efectos secundarios, con especial acento en el estreñimiento, y se propuso un nuevo esquema de tratamiento. Los participantes trabajan actualmente en unidades de dolor o de paliativos por todo México y algunos son participante activos en la elaboración de medidas reguladoras sobre el uso de opiáceos. Durante la elaboración de esta guía, se ha publicado la Ley de Reforma del Tratamiento Paliativo de México, que ha entrado en vigor el 6 de enero de 2009.At the end of September 2008, 15 leading figures in pain treatment and palliative care in Mexico met in Mexico City to design a clinical guideline on the use of opioids and the secondary effects of these drugs, with special emphasis on constipation. A new treatment scheme was proposed. The participants currently work in pain or palliative care units throughout Mexico and some are active participants in the design of regulatory measures on opioid use. During the drafting of this guideline, the law reforming palliative treatment in Mexico was passed and came into effect on 6th January, 2009.

  9. Detecção da encefalopatia hepática subclínica por espectroscopia cerebral Detection of subclinical hepatic encephalopathy by magnetic resonance spectroscopy

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    Gustavo Justo Schulz

    2007-06-01

    Full Text Available RACIONAL: A encefalopatia hepática é anormalidade neuropsiquiátrica comum em cirróticos e está associada com alterações típicas de determinados metabólitos cerebrais, como o decréscimo de mio-inositol e colina e o aumento de glutamina-glutamato, observadas na espectroscopia cerebral por ressonância magnética. OBJETIVO: Determinar os níveis dos metabólitos cerebrais em pacientes cirróticos para diagnóstico da encefalopatia hepática em estágios iniciais. MÉTODOS Foram estudados 25 pacientes com cirrose hepática, do Serviço de Transplante Hepático da Universidade Federal do Paraná, através de avaliação clínica (exame neurológico e testes neuropsicométricos e espectroscopia por ressonância magnética cerebral. A área espectral estudada por ressonância magnética envolveu a região occipital (substância branca e cinzenta. Trinta voluntários sadios formaram o grupo controle. RESULTADOS: A encefalopatia hepática subclínica foi diagnosticada em 12 pacientes (48%. Reduções significativas nos índices de MI/Cr foram observadas nos pacientes com encefalopatia quando comparados aos controles (0,49±0,10 vs. 0,83±0,13; P BACKGROUND: Hepatic encephalopathy is a common neuro-psychiatric abnormality in liver cirrhosis associated with typical changes of cerebral metabolite pattern, such as a decrease of myo-inositol and cholina and increase of glutamine-glutamate, observed by magnetic resonance spectroscopy. AIM: To determine cerebral metabolite ratios in liver cirrhosis patients with early stages of hepatic encephalopathy. METHODS: Twenty-five patients with chronic hepatic failure from Liver Transplantation Unit of the Federal University of Paraná were studied with clinical evaluation and magnetic resonance spectroscopy. Localized magnetic resonance spectra were acquired in the occipital gray/white matter regions. Thirty healthy volunteers were also subjected to the same evaluations, making up the control group. RESULTS

  10. Detecção da encefalopatia hepática subclínica por espectroscopia cerebral Detection of subclinical hepatic encephalopathy by magnetic resonance spectroscopy

    OpenAIRE

    Gustavo Justo Schulz; Julio Cézar Uili Coelho; Jorge Eduardo Fouto Matias; Antônio Carlos Ligocki Campos; Danielle Duck Schulz; Guilherme Augusto Bertoldi

    2007-01-01

    RACIONAL: A encefalopatia hepática é anormalidade neuropsiquiátrica comum em cirróticos e está associada com alterações típicas de determinados metabólitos cerebrais, como o decréscimo de mio-inositol e colina e o aumento de glutamina-glutamato, observadas na espectroscopia cerebral por ressonância magnética. OBJETIVO: Determinar os níveis dos metabólitos cerebrais em pacientes cirróticos para diagnóstico da encefalopatia hepática em estágios iniciais. MÉTODOS Foram estudados 25 pacientes com...

  11. Efectos hematológicos inducidos por los programas de hipoxia intermitente

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    Domingo J. Ramos Campo

    2013-01-01

    Full Text Available Entre las estrategias de entrenamiento en condicio- nes de altitud simulada más utilizadas destaca la expo- sición a hipoxia intermitente ( IHE , la cual se aplica me- diante la estancia pasiva en habitaciones con ambiente hipóxico o a través de la respiración de aire con menos concentración de O 2 , junto con el método denomina- do entrenamiento en hipoxia intermitente ( IHT , que consiste en llevar a cabo sesiones de entrenamiento en condiciones de hipoxia (Millet, Roels, Schmitt, Woorons & Richalet, 2010. Los efectos de los programas de exposición y entre- namiento en hipoxia intermitente se relacionan con un incremento de la eritropoyesis que deriva en una mejora de parámetros fisiológicos relacionados con el rendimiento, como el umbral anaeróbico o el consumo máximo de oxígeno y un incremento del rendimiento anaeróbico. Tal como observamos en la literatura, los programas IHT parecen ser mucho más beneficiosos que los de IHE para estimular la eritropoyesis e incrementar el rendi- miento deportivo, si bien con ambos métodos se obser- va una mejora en los valores sanguíneos claves para la neoformación de glóbulos rojos y que afectan al ren- dimiento deportivo. Fundamentalmente esto se debe a que el ejercicio en hipoxia juega un rol importante en las adaptaciones hematológicas y fisiológicas del orga- nismo, si bien en este campo de investigación aún hay preguntas básicas que deben ser contestadas (Hoppeler & Vogt, 2001.

  12. Tuberculoma cerebral

    OpenAIRE

    BARROSO ELIZABETH CLARA; OLIVEIRA TÂNIA REGINA BRÍGIDO DE; AMARAL ANA MARIA DANTAS DO; PINHEIRO VALÉRIA GÓES FERREIRA; SOUSA ANA LÚCIA DE OLIVEIRA

    2002-01-01

    Relata-se o caso de paciente com crises convulsivas de início recente. A tomografia computadorizada cerebral evidenciou imagem sugestiva de lesão expansiva metastática frontoparietal direita. A investigação de tumor primário ou outra doença foi negativa e o exame histopatológico do tecido cerebral diagnosticou tuberculoma. As convulsões foram controladas com a associação de hidantoína 300mg/dia ao esquema específico, utilizado por 18 meses. A tuberculose do sistema nervoso central representa ...

  13. Malaria cerebral Cerebral malaria

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    Carlos Hugo Zapata Zapata

    2003-03-01

    Full Text Available La malaria Cerebral (MC es la complicación más frecuente de la malaria por P. falciparum; aproximadamente el 90% de las personas que la han padecido se recuperan completamente sin secuelas neurológicas. Aún no se conoce con claridad su patogénesis pero se han postulado cuatro hipótesis o mecanismos posibles: 1 citoadherencia y secuestro de glóbulos rojos parasitados en la microvasculatura cerebral; 2 formación de rosetas y aglutinación de glóbulos rojos parasitados; 3 producción de citoquinas y activación de segundos mensajeros y, 4 apertura de la barrera hematoencefálica. Sin embargo, queda un interrogante sin resolver aún: ¿qué proceso se lleva a cabo para que el parásito, desde el espacio microvascular, pueda interferir transitoriamente con la función cerebral? Recientemente se ha utilizado el precursor de la proteína b-Amiloide como un marcador de daño neuronal en MC; este precursor será de gran ayuda en futuras investigaciones realizadas en nuestro medio que aporten información para comprender la patogénesis de la MC. Is the most common complication of P. falciparum malaria; nearly 90% of people who have suffered CM can recover without neurological problems. Currently there are four hypotheses that explain pathogenesis of CM: cytoadherence and sequestering of parasitized red blood cells to cerebral capillaries; rosette formation and parasitized red blood cells agglutination; production of cytokines and activation of second messengers and opening of the blood-brain barrier. However the main question remains to be answered; how the host-parasite interaction in the vascular space interferes transiently with cerebral function? Recently, the beta amyloid precursor peptide has been employed as marker of neural injury in CM. It is expected that the beta amyloid precursor peptide will help to understand the pathogenesis of CM in complicated patients of endemic areas of Colombia.

  14. Inducción de defectos de agrietamiento por hidrógeno a alta temperatura para la fabricación de patrones de calibración para ultrasonidos TOFD

    OpenAIRE

    Álvarez Cueva, Jesús Ángel

    2016-01-01

    Las probetas para ensayo se han fabricado por soldeo en la planta piloto de Fundación ITMA, reproduciendo así las condiciones de fabricación con parámetros de soldeo típicos de los fabricantes de recipientes a presión. Los defectos por HTHA se han inducido en el reactor de hidrógeno de Disbonding del ITMA, con parámetros operativos de carga de hidrógeno a alta presión parcial y alta temperatura. Finalmente sobre las probetas con defectos inducidos por HTHA, se ha realizado una evaluación meta...

  15. Cerebral X-linked adrenoleukodystrophy: follow-up with magnetic resonance imaging Adrenoleucodistrofia ligada ao X: acompanhamento por ressonância magnética

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    Emerson L. Gasparetto

    2006-12-01

    Full Text Available OBJECTIVE: To report a case of childhood cerebral X-linked adrenoleukodystrophy (X-ADL, emphasizing the magnetic resonance imaging (MRI findings at initial evaluation and at the follow-up. CASE REPORT: Five year-old boy, who was asymptomatic, presented with diagnosis of X-ADL for MRI evaluation. The initial brain MRI showed a focal area of enhancement at the splenium of the corpus calosum. One year later, the follow-up MRI showed a progression of the corpus calosus lesion, as well as other lesions in the parietal and occipital lobes. CONCLUSION: The brain MRI follow-up of patients with X-ADL is important to show the progression of the lesions.OBJETIVO: Relatar um caso de adrenoleucodistrofia ligada ao X (X-ADL, enfatizando os achados de ressonância magnética (RM na avaliação inicial e no seguimento. DESCRIÇÃO DO CASO: Paciente masculino de cinco anos de idade, assintomático, com diagnóstico de X-ADL, apresentou-se para estudo de RM. O exame inicial mostrou uma área focal de realce no esplênio do corpo caloso. Após um ano, a RM de seguimento evidenciou aumento da lesão do corpo caloso, assim como novas lesões nos lobos occipitais e parietais. CONCLUSÃO: O seguimento por RM de pacientes com X-ADL é importante para a demonstração da progressão das lesões.

  16. O exercício físico atenua o déficit autonômico cardíaco induzido pelo bloqueio da síntese do óxido nítrico El ejercicio físico atenúa el déficit autonómico cardiaco inducido por el bloqueo de la síntesis de óxido nítrico Physical exercise attenuates the cardiac autonomic deficit induced by nitric oxide synthesis blockade

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    Bruno Rafael Orsini Rossi

    2009-01-01

    íntesis del NO sobre el control autonómico cardiovascular en ratones sometidos al ejercicio aerobio durante diez semanas. MÉTODOS: Se dividieron ratones wistar en cuatro grupos: control tratados con ración y agua ad libitum durante diez semanas (RC; control tratados con NG-nitro-L-arginina metil éster (L-NAME en la última semana (RCL; entrenados durante diez semanas en cinta motorizada (RT; entrenados por diez semanas y tratados con L-NAME en la última semana (RTL. Se investigó el control autonómico cardiovascular en todos los grupos con la utilización de doble bloqueo con metilatropina y propranolol, y análisis de la variabilidad. RESULTADOS: Los grupos RCL y RTL presentaron hipertensión. El grupo RCL presentó taquicardia y predominio del tono simpático en la determinación de la FC tras el bloqueo autonómico farmacológico. El grupo RT presentó bradicardia y menor frecuencia cardiaca (FC intrínseca en relación a los demás. La evaluación de la variabilidad de la FC mostró menores valores absolutos y normalizados en la banda de baja frecuencia (BF en el grupo RCL. El grupo RTL presentó elevación en la banda de BF en valores absolutos. El análisis de la variabilidad de la PAS mostró que los grupos RCL y RTL presentaron mayores valores en la banda de BF. CONCLUSIÓN: El ejercicio físico previo impidió el déficit en el control autonómico cardiaco inducido por el tratamiento con L-NAME, pero no impidió el aumento en la variabilidad de la PAS.BACKGROUND: The nitric oxide (NO synthesis blockade is characterized by an increase in the cardiac sympathetic activity and the physical training promotes the decrease in the sympathetic activity. OBJECTIVE: We investigated the effect of the NO synthesis blockade on the autonomic cardiovascular control in rats submitted to aerobic exercises during a 10-week period. METHODS: Male Wistar rats were divided in four groups: control rats, treated with chow food and water ad libitum for 10 weeks (CR; control rats

  17. Creencias en torno al aborto inducido en un hospital público

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    Cruz García Lirios

    2013-06-01

    Full Text Available Objetivo: Establecer las propiedades psicométricas de un instrumento que pondera las creencias en torno al aborto inducido. Método: Se llevó a cabo un estudio correlacional y transversal con una muestra no probabilística de 120 derechohabientes de un hospital público ubicado en una entidad del centro de país. Materiales: Se construyó una Escala de Creencias en torno al Aborto Inducido la cual incluyó 17 reactivos con dos opciones de respuesta: falso o verdadero. Resultados: Para establecer la confiabilidad se estimó una curtosis multivariable de -2,578unaalfade0,73 y esfericidad de 0,832 con adecuación significativa. Se estableció un modelo estructural reflectivo (X² = 16,25; 11gl; p = 0,055; GFI = 0,975; RMR = 0,008 que se ajustó al modelo de medición (GFI = 0,90; RMR = 0,01. Discusión: Se recomienda la inclusión de otras variables tales como religión, usos y costumbres locales para explicar posibles modelos regionales de prácticas abortivas inducidas legalmente.

  18. Percepção de conflito em uma família recasada constituída por um filho com paralisia cerebral Perception of conflict in a stepfamily with a child with cerebral palsy

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    Hilda Rosa Moraes de Freitas

    2012-03-01

    Full Text Available O aumento no número de separação/divórcio favorece o surgimento de novas estruturas familiares. Nesse sentido, o recasamento desponta como uma possibilidade de ordenamento do grupo familiar, que impõe à nova família uma reorganização, sobretudo nas vidas afetiva, social e econômica, assim como maior flexibilidade para negociar questões de associação, espaço, autoridade e tempo. O objetivo deste artigo foi descrever a estrutura e a dinâmica de uma família recasada, na qual há uma criança com paralisia cerebral, a partir de suas representações acerca de situações de conflito. Neste estudo de caso, foi pesquisada uma família, constituída, por três membros, mãe, filho e padrasto; foram aplicados um roteiro de entrevista semiestruturado e o Family System Test (FAST. Os escores obtidos no FAST demonstraram proximidade na díade mãe-filho e distanciamento na díade padrasto-enteado, com a hierarquia concentrada na mãe; quanto à flexibilidade das fronteiras, a percepção do casal indicou fronteiras rígidas tanto no sistema familiar quanto no parental, diferenciando-se da percepção do filho sobre o sistema familiar com uma fronteira difusa. Portanto, alguns fatores destacados na literatura e presentes nessa família como: diferença no ciclo de vida do casal; pouco tempo de união; bagagem emocional entre mãe e filho, associados às demandas de cuidado da criança, seus recursos biopsicológicos e disposições; configuraram um padrão rígido, com baixa flexibilidade, o que dificulta a inserção do padrasto no grupo e, consequente, assunção de co-paternidade nos cuidados e criação do enteado.The increase in the number of separation/divorce has favored the emergence of new family structures. Thus, remarriage becomes a possibility for developing the family group which requires emotional, social and economic reorganization of the family, as well as greater flexibility to negotiate association, space, time and

  19. Tuberculoma cerebral Cerebral tuberculoma

    Directory of Open Access Journals (Sweden)

    ELIZABETH CLARA BARROSO

    2002-01-01

    Full Text Available Relata-se o caso de paciente com crises convulsivas de início recente. A tomografia computadorizada cerebral evidenciou imagem sugestiva de lesão expansiva metastática frontoparietal direita. A investigação de tumor primário ou outra doença foi negativa e o exame histopatológico do tecido cerebral diagnosticou tuberculoma. As convulsões foram controladas com a associação de hidantoína 300mg/dia ao esquema específico, utilizado por 18 meses. A tuberculose do sistema nervoso central representa 5-15% das formas extrapulmonares e é reconhecida como de alta letalidade. Apresentação tumoral como a relatada é rara, particularmente em imunocompetentes. Quando tratada, pode ter bom prognóstico e deve entrar sempre no diagnóstico diferencial de massas cerebrais.It is reported a case of a previously healthy man with seizures of sudden onset. A contrast head computerized tomogram (CT showed a right frontoparietal expanding lesion suggesting to be metastatic. No prior disease was found on investigation. The histologic exam of the brain revealed tuberculoma. The seizures were controlled with Hidantoin 300 mg/day and antituberculosis chemotherapy for 18 months. Central nervous system tuberculosis (5-15% of the extrapulmonary forms is highly lethal. The case reported herein is specially rare in immunocompetent patients. It may have good prognosis and should be considered in the differential diagnosis of brain tumours.

  20. Entrenamiento de la capacidad aeróbica por medio de la terapia acuática en niños con parálisis cerebral tipo diplejía espástica

    OpenAIRE

    Nandy Fajardo-López; Fabiola Moscoso-Alvarado

    2013-01-01

    Antecedentes. La parálisis cerebral tipo diplejía espática genera cambios en el sistema cardiovascular que afectan la capacidad aeróbica. La terapia acuática es una estrategia terapéutica óptima tanto para el manejo de la población como para el entrenamiento de la capacidad aeróbica, por las respuestas fisiológicas que genera y porque brinda la facilidad de generar mayores cargas al sistema cardiovascular con menores riesgos que en tierra. Objetivo. Identificar las características que debe te...

  1. El aborto inducido. Una visión histórica de su manejo.

    Directory of Open Access Journals (Sweden)

    Manuel Antonio Artuz

    2009-11-01

    Full Text Available El aborto inducido es un problema de interés para la salud pública mundial, tanto en los países donde las leyes lo permiten como en aquellos donde el procedimiento se practica en forma clandestina. El presente artículo es el resultado de una revisión bibliográfica de los métodos más comúnmente empleados en la inducción del aborto en los últimos 50 años, comparándolos con los métodos utilizados en la actualidad, analizando sus riesgos y complicaciones a corto y largo plazo y tratando de sistematizar y actualizar el conocimiento que se tiene al respecto.

  2. Infarto cerebral hemorrágico por embolización de un trombo mural cardíaco Hemorrhagic cerebral infarction due to embolization of a mural thrombus within the right ventricle

    OpenAIRE

    Marín, R; Rico, A.; Blanco, M.; E. Barrero; I. Manresa; Santos, M.; J. Lucena

    2008-01-01

    Las enfermedades cerebrovasculares son consecuencia de una alteración en la circulación cerebral. Su forma más distintiva de presentación es el ictus, entendido como un déficit neurológico focal de instauración brusca y evolución rápida. Un infarto cerebral de origen oclusivo puede deberse bien a una trombosis in situ o bien a una embolia procedente de un foco distante. En las embolias cerebrales la causa principal son los trombos murales cardiacos y el área encefálica afectada con mayor frec...

  3. A compreensão do significado cultural do aneurisma cerebral e do tratamento atribuídos pelo paciente e familiares: um estudo etnográfico La comprensión del significado cultural del aneurisma cerebral y del tratamiento atribuídos por el paciente y los familiares: un estudio etnográfico The cultural meaning of cerebral aneurysm and its treatment for the patient and relatives: an ethnographic study

    Directory of Open Access Journals (Sweden)

    Maria Helena Pinto

    2000-01-01

    Full Text Available Este trabalho consiste de um estudo etnográfico descritivo, com 13 pacientes acometidos pelo aneurisma cerebral e seus familiares, com o objetivo de compreender o significado da doença e do tratamento. Os dados foram coletados por entrevistas e observações durante a hospitalização e depois da alta, no ambulatório e na residência. O tema central obtido do estudo foi "Tinha que ser para mim. Deus sabe o que faz". Este tema revela uma interpretação religiosa para a doença e uma fundamentação mágica para o tratamento. Assim, o aneurisma cerebral é interpretado como uma doença material (corpo e uma doença espiritual (alma.Esta investigación consiste en un estudio etnográfico de los pacientes afectados por aneurisma cerebral y sus familiares, con el objetivo de objetivo de comprender el significado de la enfermedad y el tratamiento. Los datos fueron recolectados por entrevistas y observaciones durante la hospitalización y después del alta en la consulta externa y en la residencia. El tema central obtenido del estudio fue: "Tenia que ser para mi. Dios sabe lo que hace". Este tema manifiesta una interpretación religiosa para la enfermedad y una fundamentación mágica para el tratamiento. Así, el aneurisma cerebral es comprendido como una enfermedad material (del cuerpo y una enfermedad espiritual (del alma.This is a descriptive ethnographic study with 13 patients with cerebral aneurysm and their relatives aiming at understanding the meaning of the illness and the treatment. The data were collected by interviews and observations during the hospitalization and, after the discharge, in the outpatient clinic and at home. The central theme obtained from the study was "It had to be for me! God knows what He does". This theme reveals a religious interpretation for the illness and a magic basis for its cure.Thus, cerebral aneurysm is interpreted as a material illness (body and a spiritual illness (soul.

  4. Estudio de la densidad ósea en niños y adolescentes con afectación moderada y severa por parálisis cerebral

    OpenAIRE

    Tatay Díaz, Ángela

    2016-01-01

    Falta palabras claves El término Parálisis Cerebral describe un grupo de trastornos permanentes del movimiento y la postura que provocan limitación de la actividad y que son secundarios a un daño puntual y no progresivo en el cerebro en desarrollo. Los trastornos motores de la Parálisis Cerebral se acompañan con frecuencia de alteraciones sensitivas, perceptivas, cognitivas, de la comunicación y el comportamiento, epilepsia y problemas secundarios a nivel del sistema musculoesquelético. ...

  5. Profilaxia do prurido causado pela administração subaracnóidea de sufentanil: efeitos do droperidol, da nalbufina, do ondansetron e da combinação deles Profilaxis del prurito inducido por la administración subaracnoidea de sufentanil: influencia do droperidol, da nalbufina, do ondansetron y da combinacion de elles Prevention of itching after spinal sufentanil: effects of droperidol, nalbuphine, ondansetron and the association of them

    Directory of Open Access Journals (Sweden)

    André Kolm

    2006-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O uso espinhal de opióides pode causar alguns efeitos indesejáveis, dentre os quais, o mais freqüente é o prurido que, apesar de sua baixa morbidade, pode proporcionar desconforto intenso ao paciente e prolongar o período de internação. O objetivo deste estudo foi avaliar diversas opções terapêuticas no tratamento profilático do prurido após administração de sufentanil por via subaracnóidea. MÉTODO: Foram distribuídos de maneira aleatória, por sorteio, 100 pacientes a serem submetidos à intervenção cirúrgica não-obstétricas em cinco grupos, de acordo com o tratamento utilizado: controle (ausência de tratamento - C; droperidol 2,5 mg (D; nalbufina 10 mg (N; associação dos medicamentos anteriores (DN e ondansetron 8 mg (O. O prurido foi avaliado quantitativamente 30 minutos, 1, 2, e 3 horas após a administração subaracnóidea de sufentanil. RESULTADOS: Os grupos C e O apresentaram incidência significativamente maior de prurido em relação aos grupos D, N e DN. Entretanto, não houve diferença significativa na necessidade de tratamento específico com naloxona entre os grupos tratados. CONCLUSÕES: O tratamento profilático do prurido neste estudo, independentemente do fármaco utilizado, diminuiu sua intensidade e limitou a necessidade de tratamento específico com naloxona.JUSTIFICATIVA Y OBJETIVOS: El uso espinal de opioides puede ser causa de efectos indeseables, entre los que el prurito es el más frecuente y a pesar de su escasa morbilidad puede ser causa de intenso desconfort y prolongar el tiempo de internación. El objetivo de este estudio es evaluar diferentes opciones terapéuticas para la prevención del prurito que ocurre después de la administración subaracnoidea de sufentanil. MÉTODO: Cien pacientes que iban a recibir cirugías no obstétricas fueron divididos aleatoriamente (sorteo en 5 grupos de acuerdo al tratamiento preventivo usado: control (sin tratamiento, grupo C

  6. Efeito do sulfato de vanadil sobre o comprometimento metabólico muscular induzido pela imobilização de membro posterior de ratos Efecto del sulfato de vanadil sobre comprometimiento metabólico muscular inducido por la inmovilización del miembro posterior en ratones Effect of the vanadyl sulphate on the muscular metabolic compromising induced by immobilization of posterior limb of rats

    Directory of Open Access Journals (Sweden)

    Gabriel Borges Delfino

    2006-12-01

    Full Text Available A proposta deste trabalho foi avaliar o efeito do sulfato de vanadil (SV no perfil metabólico muscular de membro posterior imobilizado de ratos. Ratos Wistar foram divididos nos grupos (n = 6: controle (C, imobilizado em posição neutra do tornozelo (I, tratado com sulfato de vanadil (SV, 0,25mM, VO e imobilizado tratado com SV (I + SV durante sete dias. Após o período experimental, foram avaliadas as reservas de glicogênio (RG dos músculos sóleo (S, gastrocnêmio branco (GB e vermelho (GV, tibial anterior (TA e extensor longo dos dedos (ELD, além do peso do S e ELD. A análise estatística foi realizada pela ANOVA seguida pelo teste de Tukey (p La propuesta de este trabajo ha sido la de evaluar el efecto del sulfato de vanadil (SV en el perfil metabólico muscular de miembro posterior inmovilizado de ratones. Ratones Wistar fueron divididos en grupos (n = 6: control (C, inmovilizado en posición neutra de tobillo (I, tratado con sulfato de vanadil (SV, 0,25mM, VO e inmovilizado tratado con SV (I + SV durante 7 días. Después del periodo experimental, fueron evaluadas las reservas de glicógeno (RG de los músculos soleo (S, gastrocnemio blanco (GB y colorado (GV, tibial anterior (TA y extensor largo de los dedos (ELD, además del peso de S y ELD. El análisis estadístico fue realizado por ANOVA seguido del test de Tukey (p The purpose of this study was to evaluate the metabolic performance of immobilized skeletal muscle in rats treated with vanadyl sulphate. Male Wistar rats were divided in groups (n = 6: control (C, immobilized (I, treated with vanadyl sulphate (VS, 0,25 mM and immobilized treated with vanadyl sulphate (I + VS during seven days. The concentration of vanadyl sulphate diluted in water was 0,25 mM. After experimental stage, the glycogen content (GC was evaluated in soleus (S, white gastrocnemius (WG, red gastrocnemius (RG, tibialis anterior (TA and extensor digitorum longus (EDL muscles, besides S and EDL weight. The

  7. Cerebral Hypoxia

    Science.gov (United States)

    ... Enhancing Diversity Find People About NINDS NINDS Cerebral Hypoxia Information Page Synonym(s): Hypoxia, Anoxia Table of Contents ( ... Trials Organizations Publicaciones en Español What is Cerebral Hypoxia? Cerebral hypoxia refers to a condition in which ...

  8. Formação de conceitos por crianças com paralisia cerebral: um estudo exploratório sobre a influência de atividades lúdicas Concept development by children with cerebral palsy: a study about the influence of playful activities

    Directory of Open Access Journals (Sweden)

    Ana Paula Martins Cazeiro

    2011-01-01

    Full Text Available O objetivo deste trabalho foi investigar a influência de atividades lúdicas no processo de formação de conceitos espontâneos por crianças com seqüelas de paralisia cerebral. Participaram da pesquisa sete crianças, que foram submetidas a um pré-teste de conceitos espontâneos, sessões individuais de atividades lúdicas que envolviam alguns dos conceitos avaliados e reaplicação do teste inicial a fim de avaliar o grau de desenvolvimento dos conceitos. Todas as crianças participantes desenvolveram ao menos um dos conceitos mais vivenciados nas sessões de atividades lúdicas, além de terem desenvolvido outros conceitos espontâneos não avaliados por meio dos testes.The objective of this research was to investigate the influence of playful activities in the process of developing basic concepts by children with cerebral palsy. The subjects were seven children who have been submitted to a pre-test of basic concepts; individual sessions of playful activities, which involved some of the evaluated concepts; and a second administration of the initial test in order to assess the degree of learning of such concepts. Every child has learned at least one of the concepts involved in the sessions of playful activities. They have also learned other concepts not evaluated by basic concepts tests.

  9. Cuidar de pessoa incapacitada por acidente vascular cerebral no domicílio: o fazer do cuidador familiar El cuidado de la persona incapacitada por accidente cerebro vascular en el domicilio: el hacer del cuidador familiar Taking care of persons handicapped by cerebral vascular accident at home: the familial caregiver activity

    Directory of Open Access Journals (Sweden)

    Nara Marilene Oliveira Girardon Perlini

    2005-06-01

    Full Text Available Estudo exploratório, descritivo e quantitativo que busca identificar e descrever as atividades do familiar que cuida de pessoas incapacitadas por AVC no domicílio. A amostra constituiu-se de 35 cuidadores familiares, predominantemente mulheres, esposas ou filhas. Os cuidados realizados relacionam-se ao grau de incapacidade do familiar. As orientações recebidas denotam falta de compromisso dos profissionais com a continuidade do cuidado. O cuidador aprende a cuidar no cotidiano, com base na observação e auxílio à enfermagem na internação. As dificuldades pautam-se no esforço físico, na desinformação e no medo, no constrangimento e na vergonha em lidar com o corpo do outro. O estudo enfoca a necessidade do preparo para a alta hospitalar, salienta a família como espaço concreto para o cuidado; o aumento da expectativa de vida é uma constatação.Estudio exploratorio, descriptivo y cuantitativo que busca identificar y describir las actividades del familiar que cuida de personas incapacitadas por ACV en el domicilio. La muestra estuvo constituida de 35 cuidadores familiares, predominantemente mujeres, esposas o hijas. Los cuidados realizados se relacionan con el grado de incapacidad del familiar. Las orientaciones recibidas denotan falta de compromiso de los profesionales con la continuidad del cuidado. El cuidador aprende a cuidar en el cotidiano, con base en la observación y el auxilio prestado a enfermería durante el internamiento. Las dificultades se pautan en el esfuerzo físico, en la desinformación y en el miedo, en el recelo y en la vergüenza para lidiar con el cuerpo del otro. El estudio enfoca la necesidad de preparación para la alta hospitalaria y resalta la familia como espacio concreto para el cuidado; el aumento de la expectativa de vida es una constatación.An exploratory descriptive and quantitative study aimed at identifying and describing the activity of relatives in charge of caring at home for people

  10. Degradation of polyethylene induced by plasma in oxidizing atmospheres; Degradacion de polietileno inducido por plasma en atmosferas oxidantes

    Energy Technology Data Exchange (ETDEWEB)

    Colin, E.; Olayo, M.G.; Cruz, G.J. [Facultad de Quimica, UAEM, Av. Tollocan y Colon, 50000 Toluca (Mexico)

    2002-07-01

    The garbage of polyethylene is not easily degradable in normal environmental conditions . The indiscriminate use of this polymer and the enormous quantity of garbage which is generated carries a damage to the environment due to its long life as waste. The objective of this work is to study the conditions in which can be carried out the degradation of polyethylene. A form of accelerating the degradation is exposing it to plasma with reactive atmospheres. In this work a study of surface modification of polyethylene by plasmas with discharges of direct current of oxygen and nitrogen is presented. (Author)

  11. Changes in the chromogene properties of the betalaine; Cambios en las propiedades cromogenas de las betalainas inducidos por radiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez N, S.; Pinedo S, A.; Amador V, P.; Chacon R, A.; Arcos P, A.; Vega C, H.R. [Unidad Academica de Ciencias Nucleares, C. Cipres 10, Fracc. La Penuela, 98068, Zacatecas, Zac. (Mexico)

    2005-07-01

    The changes of coloration of four natural extracts were determined in function of the absorbed dose taken place by a source of rays gamma of Cs-137. The used natural extracts contain betalaine that are natural pigments of some plants as the beet root, of there their name. They are also in abundant form in the fruits (tunas) of some species of the Opuntia gender. The extracts were obtained by maceration, starting from beet root and three tuna varieties, and they were stabilized to pH 5.5 the change of coloration you determines in a spectrophotometer ultraviolet/visible by means of the absorbance from the samples to photons of 475, 535 and 600 nm of wave longitude. The absorbance was measured, to different intervals of time. The relationship settled down between the absorbed dose and the chromogene properties of the pigment, with the intention of using it as possible dosemeter. (Author)

  12. Cambios inducidos por el aprendizaje en el sistema motor de las vibrisas de ratón

    Directory of Open Access Journals (Sweden)

    José María Delgado García

    2005-03-01

    Full Text Available Aunque se sabe que la corteza motora primaria comanda movimientos corporales, aún no se conoce con precisión cómo ejerce este control. En este trabajo se estudió la participación de la corteza motora primaria durante el aprendizaje motor en el sistema sensitivo-motor de las vibrisas en ratones

  13. Estudio de los procesos celulares inducidos por campos eléctricos en sistemas Lab-on-a-Chip

    OpenAIRE

    Oliva Brañas, Ana María

    2014-01-01

    En esta tesis doctoral se ha estudiado de forma sistemática la relación entre los campos eléctricos y las células, y los efectos que éstos tienen a diferentes niveles (supervivencia, metabolismo, expresión proteica, morfología), en dispositivos de tipo Lab-on-a-Chip y aplicándolo a un caso concreto de un concentrador basado en dielectroforesis. Se ha realizado de manera que se ha podido diferenciar la aportación de cada uno de los parámetros eléctricos a los cambios. Se ha diseñado, fabr...

  14. Acidente vascular cerebral hemorrágico associado à acidente ofídico por serpente do gênero bothrops: relato de caso Hemorrhagic stroke related to snakebite by bothrops genus: a case report

    Directory of Open Access Journals (Sweden)

    Amanda Silva Machado

    2010-10-01

    Full Text Available Este trabalho tem como objetivo relatar um caso de acidente vascular cerebral hemorrágico, associado à acidente ofídico por serpente do gênero bothrops e hipertensão arterial sistêmica grave. Apesar do ofidismo botrópico ser frequente no Estado do Pará, tais associações são incomuns, necessitando de uma abordagem especializada e precoce, visando menores complicações.This research reports a clinical case of hemorrhagic stroke due to envenomation by bothrops snakebite associated with severe hypertension. Although bothrops snakebites are frequent in the State of Pará, such associations are uncommon, requiring specialized and early management to avoid severe complications.

  15. Evidencias de compromiso cerebral en el estadio crónico de la enfermedad de Chagas obtenidas por medio del potencial P300 y de electroencefalografía cuantificada

    Directory of Open Access Journals (Sweden)

    PROST JULIO OSCAR

    2000-01-01

    Full Text Available Es reconocido el compromiso del sistema nervioso periférico en la etapa crónica de la enfermedad de Chagas, incorporándose últimamente evidencias tomográficas y neuropsicológicas de compromiso cerebral. Con el objetivo de evaluar dicho compromiso por medio del potencial P 300 y la electroencefalografía cuantificada (EEGc se estudiaron 35 pacientes (26 a 55 años, comparados con un grupo control de similar número y edad (29 a 55 años. Se observó: latencia de la onda P 3 mayor en el grupo en estudio (331,24 ± 24,02 contra 318,86 ± 23,18 (p=0,01716. El EEGc mostró diferencias en la potencia relativa de la banda Beta 1, menor en los pacientes (p=1,62834E5 y en la frecuencia dominante, 1 Hz menor en los chagasicos (p=0,01077. El análisis multivariado discrimina tres subpoblaciones: una normal, una de enfermos con incremento alfa y otra de enfermos con decremento alfa e incremento delta y theta (p=0,00004. La proporción de resultados patológicos fue del 20 % en los EEGc y el 11,43 % en los potenciales cognitivos. No se correlacionó el compromiso neurológico y el cardíaco. Se concluye que existen francos indicadores electrofisiológicos de compromiso cerebral en el estadio crónico de la enfermedad de Chagas, hallazgo que refuerza a los obtenidos por otros métodos.

  16. Productos de innovaciones teoricas Hi desarrollo de la actividad mental-cerebral mediado por sistemas fisiológicos y agentes externos

    OpenAIRE

    Helmer Frank Charris Peredo; Luis Gabriel Martinez Vergel; Claudio Alejandro Jimenez Monsalve

    2013-01-01

    La variedad de opiniones que se levantan con el propósito de explicar con alguien grado de proximidad la mente del hombre, resultan ocasionalmente incompletas, pero cada una de esas afirmaciones termina por hacer parte, de una solo concepción donde todas las posibilidades tanto neurofisiológicas como psicológicas se pueden aplicar. Partiendo de la apreciación que la conciencia es la máxima expresión de la evolución mental, por ser una facultad que implica interacción de funciones mentales sup...

  17. Entrenamiento de la capacidad aeróbica por medio de la terapia acuática en niños con parálisis cerebral tipo diplejía espástica

    Directory of Open Access Journals (Sweden)

    Nandy Fajardo-López

    2013-12-01

    Full Text Available Antecedentes. La parálisis cerebral tipo diplejía espática genera cambios en el sistema cardiovascular que afectan la capacidad aeróbica. La terapia acuática es una estrategia terapéutica óptima tanto para el manejo de la población como para el entrenamiento de la capacidad aeróbica, por las respuestas fisiológicas que genera y porque brinda la facilidad de generar mayores cargas al sistema cardiovascular con menores riesgos que en tierra. Objetivo. Identificar las características que debe tener una propuesta de intervención fisioterapéutica para el entrenamiento de la capacidad aérobica en niños y niñas entre los 8 y los 12 años, con parálisis cerebral tipo diplejía espástica, empleando la terapia acuática. Materiales y métodos. Se desarrolló un estudio de tipo descriptivo-propositivo, en el cual se formuló una propuesta de intervención basada en información recolectada a través de referencias bibliográficas. Resultados. Se presentan en forma de propuesta de intervención, describiendo en detalle las fases del entrenamiento de la capacidad aeróbica, mediante los principios del entrenamiento y la prescripción de ejercicio físico, teniendo en cuenta las respuestas fisiológicas ante la carga, así como las características propias de la población. Conclusión. La parálisis cerebral tipo diplejía espástica, genera cambios en la capacidad aeróbica; por esto, el fisioterapeuta debe incluirla en los procesos de rehabilitación como uno de sus objetivos. Para lograrlo, la terapia acuática es una modalidad de tratamiento óptima, puesto que genera mayor seguridad de movimiento y respuestas fisiológicas favorables en el sistema cardiovascular.

  18. Multiparametric multidetector computed tomography scanning on suspicion of hyperacute ischemic stroke: validating a standardized protocol Avaliação multiparamétrica por tomografia computadorizada multidetectores na suspeita de isquemia cerebral hiperaguda: validando um protocolo padronizado

    Directory of Open Access Journals (Sweden)

    Felipe Torres Pacheco

    2013-06-01

    Full Text Available Multidetector computed tomography (MDCT scanning has enabled the early diagnosis of hyperacute brain ischemia. We aimed at validating a standardized protocol to read and report MDCT techniques in a series of adult patients. The inter-observer agreement among the trained examiners was tested, and their results were compared with a standard reading. No false positives were observed, and an almost perfect agreement (Kappa>0.81 was documented when the CT angiography (CTA and cerebral perfusion CT (CPCT map data were added to the noncontrast CT (NCCT analysis. The inter-observer agreement was higher for highly trained readers, corroborating the need for specific training to interpret these modern techniques. The authors recommend adding CTA and CPCT to the NCCT analysis in order to clarify the global analysis of structural and hemodynamic brain abnormalities. Our structured report is suitable as a script for the reproducible analysis of the MDCT of patients on suspicion of ischemic stroke.A tomografia computadorizada multidetectores (TCMD permitiu o diagnóstico precoce de isquemia cerebral hiperaguda. O presente estudo objetivou validar a interpretação e a descrição padronizada de um protocolo de TCMD multiparamétrica em uma série de pacientes adultos. A concordância entre os examinadores foi testada, e seus resultados confrontados com uma leitura padrão. Não foram observados resultados falso-positivos, e foi documentado um elevado grau de concordância (Kappa>0,81 quando os dados da angiotomografia (ATC e dos mapas de perfusão cerebral por TC (PCTC foram adicionados à análise da TC sem contraste (TCSC. A concordância interobservador foi superior para os leitores melhor treinados, corroborando a necessidade de formação específica para a interpretação dos exames. Os autores recomendam acrescer a interpretação da ATC e da PCTC à análise da TCSC, visando à análise global das anormalidades cerebrais estruturais e hemodin

  19. Productos de innovaciones teoricas Hi desarrollo de la actividad mental-cerebral mediado por sistemas fisiológicos y agentes externos

    Directory of Open Access Journals (Sweden)

    Helmer Frank Charris Peredo

    2013-12-01

    Full Text Available La variedad de opiniones que se levantan con el propósito de explicar con alguien grado de proximidad la mente del hombre, resultan ocasionalmente incompletas, pero cada una de esas afirmaciones termina por hacer parte, de una solo concepción donde todas las posibilidades tanto neurofisiológicas como psicológicas se pueden aplicar. Partiendo de la apreciación que la conciencia es la máxima expresión de la evolución mental, por ser una facultad que implica interacción de funciones mentales superiores, podríamos tener bajo cierta medida una aproximación a lo que implica la actividad mental, conociendo que el cerebro implica mecanismos fisiológicos y químicos con una funcionalidad que probablemente se moldee con el tiempo. Existen diferentes mecanismos implicados en la actividad mental superior, algunos como la memoria, se explican bajo razones fisiológicas, otros, necesitan una análisis más profundo para intentar cuando menos entender como suceden. Nuestro psiquismo no progresa únicamente por la vía de la maduración mecánica de aptitudes biológicas, condicionadas estas por el sistema nervioso central, este se organiza y desarrolla en el procedimiento de la necesidad humana de interactuar con el medio y relacionarse con sus semejantes. 

  20. Paralisia Facial Periférica por comprometimento do tronco cerebral: A propósito de um caso clínico

    OpenAIRE

    Lazarini Paulo R.; Fernandes Alessandro M. F.; Brasileiro Veridiana S. B.; Custódio Sérgio E. V.

    2002-01-01

    É apresentado um caso clínico de paciente portador de paralisia facial periférica com comprometimento de toda a hemiface direita. Durante a investigação clínica, esperava-se que o comprometimento topográfico do nervo facial se desse a partir de sua emergência na ponte. Após exames de imagem, evidenciou-se lesão expansiva no tronco cerebral. Deste modo, a classificação de paralisia facial como periférica ou central não atende a este caso. O uso de uma classificação utilizando os núcleos do ner...

  1. toxicidad neuroendocrina inducida por cadmio

    Directory of Open Access Journals (Sweden)

    A Romero

    2008-01-01

    Full Text Available El cadmio es un agente químico tóxico importante debido a su creciente nivel en el medio ambiente como resultado de prácticas industriales y agrícolas. Como perturbador endocrino, el cadmio modifica la secreción de hormonas hipofisarias. Los efectos indirectos del cadmio provocan la generación de especies reactivas de oxígeno y reducen la actividad de las proteínas implicadas en las defensas antioxidantes. La melatonina es conocida como un potente antioxidante, scavenger de radicales libres y quelante de metales sintetizada en la glándula pineal. De esta manera, las acciones antioxidantes de esta indolamina protegen frente a la peroxidación lipídica y el daño oxidativo de los radicales y de sus productos tóxicos. Los trabajos recopilados en esta revisión ponen de manifiesto la capacidad antioxidante de la melatonina y, por lo tanto, su posible papel protector frente a la toxicidad del cadmio en lo que se refiere al estrés oxidativo y peroxidación lipídica inducidos por la exposición a este metal.

  2. Cerebral Palsy

    Science.gov (United States)

    Cerebral palsy is a group of disorders that affect a person's ability to move and to maintain balance ... do not get worse over time. People with cerebral palsy may have difficulty walking. They may also have ...

  3. Respuesta de las neuronas sensitivas al estrés genotóxico inducido por radiaciones ionizantes y por la inhibición del proteasoma

    OpenAIRE

    Palanca Cuñado, Ana Rosa

    2014-01-01

    RESUMEN: Las neuronas son muy vulnerables al estrés genotóxico. Esta vulnerabilidad es particularmente relevante en las neuronas ganglionares sensitivas (NGS) dado que los ganglios carecen de barrera hematoencefálica que impida el acceso de agentes genotóxicos, como determinados fármacos utilizados en la quimioterapia del cáncer. Tales agentes producen un efecto neurotóxico que se traduce en neuropatías periféricas. Nuestro estudio analiza las bases celulares de la neurotoxicidad en las NGS e...

  4. Medida da diferença artério-venosa de oxigênio na monitorização de pacientes com hemorragia subaracnóidea por aneurisma cerebral Measurement of arteriovenous oxygen difference in the monitoring of patients with subarachnoid haemorrhage due to cerebral aneurysm

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    Ronaldo Sérgio Santana Pereira

    1997-01-01

    Full Text Available A diferença artério-venosa de oxigênio (DAVO2, pelo fato de estar relacionada com o metabolismo cerebral, reflete alterações que ocorrem em determinadas situações patológicas, entre elas as causadas pela hemorragia subaracnóidea espontânea (HSAE. Com a finalidade de avaliar a relação entre alterações na DAVO2 com o quadro clínico e a evolução de pacientes com HSAE, devido à ruptura de aneurisma cerebral, este método foi utilizado em 30 pacientes portadores desta patologia, admitidos na Unidade de Neurocirurgia do HBDF. A HSAE foi confirmada por CT de crânio em 17 pacientes e por punção lombar em 13. Dezoito pacientes foram admitidos com Hunt & Hess (H&H I ou II, sete com H&H III e cinco com H&H IV ou V. A medida da DAVO2 baseou-se na equação de Fick e os resultados clínicos foram avaliados pela escala de seqüelas de Glasgow. Dezenove pacientes apresentaram DAVO2 normais (inicialmente e durante a evolução, sendo que três faleceram; cinco tiveram valores de DAVO2 sempre baixos e três faleceram; os restantes seis pacientes tiveram valores da DAVO2 sempre elevados e dois faleceram. Os pacientes com DAVO2 normais tiveram melhor evolução clínica e índice de mortalidade menor, quando comparados com os pacientes com valores anormais da DAVO2 (pThe arterious venous oxygen difference (AVDO2 due to the close relationship with cerebral metabolic rate of oxygen and cerebral blood flow shows metabolic alterations that occur in some pathological situations in the brain including subarachnoid haemorrhage. The AVDO2 was calculated by the Fick equation and the results evaluated by the Glasgow outcome scale. Measurements of arteriojugular oxygen difference were carried out in 30 patients with subarachnoid haemorrhage due to rupture of intracranial aneurysms, as an attempt to monitor the relationship between changes in AVDO2, clinical picture, and evolution of the patients. The subarachnoid haemorrhage was diagnosed by CT scan in

  5. Não vou esquecer nunca!: a experiência feminina com o abortamento induzido "No lo olvidaré nunca!": la experiencia femenina en el aborto inducido "I'll never forget it!": women's experience with induced abortion

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    Ivanilda Lacerda Pedrosa

    2000-12-01

    Full Text Available Utilizando a abordagem do Interacionismo Simbólico, objetivamos verificar os significados atribuídos ao abortamento induzido por mulheres que adotaram essa conduta e analisar seu impacto sobre o autoconceito dessas mulheres. Nos resultados, evidenciamos a contraditoriedade dos discursos das mulheres ao avaliar a experiência, e as reações emocionais que relataram, tais como remorso/consciência pesada, arrependimento, sensação de perda e, principalmente, culpa que, segundo suas narrativas, carregariam para o resto de suas vidas.Teniendo como base el abordaje del Interaccionismo Simbólico, se pretendió averiguar cuales los significados atribuidos al aborto inducido por mujeres que optaron por esa conducta y analizar el impacto de dicha experiencia en su autoconcepto. En los resultados obtenidos se destacan la contradicción de sus discursos al evaluar la experiencia, y las reacciones emocionales que habían desarrollado, dentro de las cuales fueron relatadas remordimiento/conciencia pesada, arrepentimiento, sensación de perdida y principalmente, la culpabilidad que según sus relatos, llevarían para toda la vida.Based on the symbolic interactionist approach, we aimed to verify the meanings attributed to induced abortion by women who adopted such behavior as well as to analyze the impact of the experience on their self-image. The results point out the contradiction in women's discourse when they evaluate the experience, and the emotional negative reactions they had developed: remorse/guilty conscience, regret, feeling of grief, and mainly guilt, which, according to their accounts, they will carry for the rest of their lives.

  6. Risk factors for unpleasant paresthesiae induced by paresthesiae - producing deep brain stimulation Fatores de risco para parestesia dolorosa induzida por estimulação cerebral profuda em sítios produtores de parestesia

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    Osvaldo Vilela Filho

    1996-03-01

    Full Text Available Paresthesiae-producing deep brain stimulation (stimulation of ventrocaudal nucleus - VC, medial lemniscus - ML or internal capsule - IC is one of the few procedures to treat the steady element of neural injury pain (NIP currently available. Reviewing the first 60 patients with NIP submitted to deep brain stimulation (DBS from 1978 to 1991 at the Division of Neurosurgery, Toronto Hospital, University of Toronto, we observed that 6 patients complained of unpleasant paresthesiae with paresthesiae-producing DBS, preventing permanent electrode implantation in all of them. Such patients accounted for 15% of the failures (6 out of 40 failures in our series. In an attempt to improve patient selection, we reviewed our patients considering a number of parameters in order to determine risk factors for unpleasant paresthesiae elicited by paresthesiae-producing DBS. The results showed that this response happenned only in patients with brain central pain complaining of evoked pain, secondary to a supratentorial lesion. Age, sex, duration of pain, quality of the steady pain, size of the causative lesion and site (VC,ML,IC and type (micro or macroelectrode of surgical exploration were not important factors. Unpleasant paresthesiae in response to dorsal column stimulation, restricted thalamic lesion on computed tomography and the occurrence of associated intermittent pain were considered major risk factors in this subset of patients and the presence of cold allodynia or hyperpathia in isolation and the absence of sensory loss were considered minor risk factors. It is our hope that the criteria here established will improve patient selection and so, the overall results of DBS.A estimulação cerebral profunda (ECP de sítios cuja estimulação elicita parestesia (núcleo talâmico ventrocaudal - VC, lemnisco medial - LM e cápsula interna - CI é um dos poucos métodos atualmente disponíveis para o tratamento do elemento constante da dor por injúria neural (DIN

  7. Avaliação e participação do fisioterapeuta na prescrição do mobiliário escolar utilizado por alunos com paralisia cerebral em escolas estaduais públicas da rede regular de ensino Evaluation and participation of physical therapists on the school furniture prescription for students with cerebral palsy in public schools of the regular school network

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    Luzia Lívia Oliveira Saraiva

    2011-08-01

    Full Text Available O estudo teve como objetivo avaliar as condições do mobiliário escolar disponibilizado aos alunos com paralisia cerebral nas escolas estaduais da cidade do Natal/RN em 2008 e a participação do fisioterapeuta na prescrição deste mobiliário. Os dados foram coletados através de um protocolo de avaliação junto a cinco alunos com paralisia cerebral e formulário aplicado aos diretores das instituições de ensino, sendo analisados por meio das categorias suscitadas. Os resultados apontaram a presença de mobiliário escolar que não atende as necessidades específicas de posicionamento dos alunos avaliados e a ausência do fisioterapeuta na prescrição desse mobiliário. Constata-se a necessidade dos órgãos gestores no âmbito da educação de Natal/RN em cumprir o que determina a lei e disponibilizar mobiliário escolar adequado aos alunos pesquisados. Assim, procurou-se garantir os recursos necessários para promover um ensino de qualidade para os educandos com paralisia cerebral no contexto da escola regular.The objective of this study was to evaluate the conditions of school furniture available for students with cerebral palsy in public schools in the city Natal, Rio Grande do Norte in 2008, looking at how physical therapists participated in the process of prescribing such furniture. The data was collected using an evaluation protocol with students with cerebral palsy and with school principals who filled out forms. The analysis was undertaken according to the categories that arose from the data. The results indicated that: 1 school furniture doesn’t meet the specific positioning needs of the students that were evaluated and 2 physical therapists do not participate in prescribing appropriate furniture. The study showed that in Natal, Rio Grande do Norte, educational administrators need to carry out the policies that have been determined by law in order to make proper school furniture available to students with cerebral palsy. The

  8. Cerebral Palsy

    Science.gov (United States)

    ... 1 • 2 • 3 For Teens For Kids For Parents MORE ON THIS TOPIC Cerebral Palsy: Keith's Story Physical Therapy I Have Cerebral Palsy. Can I Babysit? Body Image and Self-Esteem Contact Us Print Resources Send to a friend ...

  9. Normative study of tympanic infrared thermometry: a non-invasive index of asymmetric cerebral activity Normatização da termometria timpânica por infravermelho: um indicador não-invasivo de atividade cerebral assimétrica

    Directory of Open Access Journals (Sweden)

    Danielle Cicarini de Landa

    2008-03-01

    da TT, e principalmente das diferenças interauriculares desse parâmetro, obtidas por termometria timpânica por infravermelho, em indivíduos normais, na ausência de execução de tarefas específicas. Foram obtidas medidas da TT em 47 voluntários normais (20 homens e 27 mulheres, com média de idade de 39,38±12,57 anos em repouso e calculadas as diferenças interauriculares, sua média e desvio-padrão. A TT média foi de 36,85±0,50ºC à direita e de 36,74± 0,57ºC à esquerda, o que está de acordo com dados da literatura. A média das diferenças de TT encontrada foi de 0,25ºC e o desvio padrão (DP 0,21ºC. Com base nesses achados, os valores máximos considerados normais para a diferença interauricular da TT, com níveis de confiança de 99% e de 95%, são de 0,88ºC e 0,67ºC, respectivamente. A utilidade da medida da diferença interauricular da TT como marcador de assimetria da atividade cerebral em pacientes com patologias neurológicas deverá ser avaliada em estudos adicionais.

  10. Cerebral palsy.

    Science.gov (United States)

    Graham, H Kerr; Rosenbaum, Peter; Paneth, Nigel; Dan, Bernard; Lin, Jean-Pierre; Damiano, Diane L; Becher, Jules G; Gaebler-Spira, Deborah; Colver, Allan; Reddihough, Dinah S; Crompton, Kylie E; Lieber, Richard L

    2016-01-01

    Cerebral palsy is the most common cause of childhood-onset, lifelong physical disability in most countries, affecting about 1 in 500 neonates with an estimated prevalence of 17 million people worldwide. Cerebral palsy is not a disease entity in the traditional sense but a clinical description of children who share features of a non-progressive brain injury or lesion acquired during the antenatal, perinatal or early postnatal period. The clinical manifestations of cerebral palsy vary greatly in the type of movement disorder, the degree of functional ability and limitation and the affected parts of the body. There is currently no cure, but progress is being made in both the prevention and the amelioration of the brain injury. For example, administration of magnesium sulfate during premature labour and cooling of high-risk infants can reduce the rate and severity of cerebral palsy. Although the disorder affects individuals throughout their lifetime, most cerebral palsy research efforts and management strategies currently focus on the needs of children. Clinical management of children with cerebral palsy is directed towards maximizing function and participation in activities and minimizing the effects of the factors that can make the condition worse, such as epilepsy, feeding challenges, hip dislocation and scoliosis. These management strategies include enhancing neurological function during early development; managing medical co-morbidities, weakness and hypertonia; using rehabilitation technologies to enhance motor function; and preventing secondary musculoskeletal problems. Meeting the needs of people with cerebral palsy in resource-poor settings is particularly challenging. PMID:27188686

  11. Cerebral hypoxia

    Science.gov (United States)

    ... the veins ( deep vein thrombosis ) Lung infections (pneumonia) Malnutrition When to Contact a Medical Professional Cerebral hypoxia ... References Bernat JL. Coma, vegetative state, and brain death. In: Goldman L, Schafer AI, eds. Goldman's Cecil ...

  12. Cerebral Paragonimiasis.

    Science.gov (United States)

    Miyazaki, I

    1975-01-01

    The first case of cerebral paragonimiasis was reported by Otani in Japan in 1887. This was nine years after Kerbert's discovery of the fluke in the lungs of Bengal tigers and seven years after a human pulmonary infection by the fluke was demonstrated by Baelz and Manson. The first case was a 26-year-old man who had been suffering from cough and hemosputum for one year. The patient developed convulsive seizures with subsequent coma and died. The postmortem examination showed cystic lesions in the right frontal and occipital lobes. An adult fluke was found in the occipital lesion and another was seen in a gross specimen of normal brain tissue around the affected occipital lobe. Two years after Otani's discovery, at autopsy a 29-year-old man with a history of Jacksonian seizure was reported as having cerebral paragonimiasis. Some time later, however, it was confirmed that the case was actually cerebral schistosomiasis japonica. Subsequently, cases of cerebral paragonimiasis were reported. However, the majority of these cases were not confirmed histologically. It was pointed out that some of these early cases were probably not Paragonimus infection. After World War II, reviews as well as case reports were published. Recently, investigations have been reported from Korea, with a clinicla study on 62 cases of cerebral paragonimiasis seen at the Neurology Department of the National Medical Center, Seoul, between 1958 and 1964. In 1971 Higashi described a statistical study on 105 cases of cerebral paragonimiasis that had been treated surgically in Japan.

  13. Cerebral palsy - resources

    Science.gov (United States)

    Resources - cerebral palsy ... The following organizations are good resources for information on cerebral palsy : National Institute of Neurological Disorders and Stroke -- www.ninds.nih.gov/disorders/cerebral_palsy/cerebral_palsy. ...

  14. Cerebral Palsy (For Parents)

    Science.gov (United States)

    ... Story" 5 Things to Know About Zika & Pregnancy Cerebral Palsy KidsHealth > For Parents > Cerebral Palsy Print A A ... kids who are living with the condition. About Cerebral Palsy Cerebral palsy is one of the most common ...

  15. Vigilancia ocupacional del trabajador expuesto a alteraciones de la salud inducidas por ruido

    Directory of Open Access Journals (Sweden)

    Julio C. Guerrero Pupo

    2005-01-01

    Full Text Available Aborda un estudio donde se analiza que la sustentabilidad terrícola está en peligro por los problemas ambientales presentes, destacando, a nivel local el ruido. Señala que es "causa" de alteraciones a la salud en ciertos puestos de trabajo y que el proceso se puede esquematizar como un eje constituido por factor de riesgo-exposición -efecto. Argumenta que empleó el método epidemiológico. Plantea la vigilancia epidemiológica hombre - ambiente y los efectos auditivos y no auditivos inducidos por ruido. Concluye que el Estado anhela su control y que su mejor representante es el médico de la familia al formarse integralmente en varias disciplinas.

  16. Neuroprotecci??n mediada por diterpenos aislados de Sideritis spp. frente al estr??s oxidativo en astrocitos

    OpenAIRE

    Gonz??lez-Burgos, E.; Palomino, O.M.; Carretero Accame, M.E.; G??mez-Serranillos, M.P.

    2010-01-01

    La presente investigaci??n aborda el estudio de las propiedades neuroprotectoras, en base a la capacidad antioxidante, de los diterpenos andalusol, conchitriol y sidol aislados de diferentes especies del g??nero Sideritis. La actividad protectora de estos compuestos fue evaluada en un modelo de estr??s oxidativo inducido por el per??xido de hidr??geno sobre la l??nea celular U373 MG de astrocitoma humano. Los resultados mostraron que un pretratamiento durante 24 horas con los dite...

  17. Diferencias en el número de cesáreas en los partos que comienzan espontáneamente y en los inducidos

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    Antonio Hernández Martínez

    2014-01-01

    Full Text Available Fundamentos: La inducción del parto (IDP puede estar asociada a mayores complicaciones para la mujer gestante. El objetivo de este trabajo fue determinar las diferencias en el número de cesáreas entre partos espontáneos y partos inducidos. Métodos: Cohortes históricas sobre un total de 841 inducciones y 2.534 partos espontáneos realizados entre 2009 y 2011 en el Hospital "Mancha-Centro" de Alcázar de San Juan. Se empleó análisis multivariante por medio de regresión logística binaria para control de la confusión. Resultados: La prevalencia de IDP fue del 22,9%, presentándose como indicaciones más frecuentes la rotura prematura de membranas (RPM de más de 12 horas (22,7% y diabetes mellitus mal controlada con un 22,5%. Se observó relación entre inducción y riesgo de cesárea tanto en mujeres nulíparas (OR= 2,68; Intervalo de confianza [IC] 95%: 2,15-3,34 como en multíparas (OR=2,10; [IC] 95%:1,72-2,57. La indicación con mayor riesgo de cesárea fue la gestación cronológicamente prolongada (GCP (37,1% seguida del registro cardiotográfico (RCTG patológico (35,3% y estados hipertensivos del embarazo (EHE (4,0%. La IDP también se relacionó con la mayor duración de la dilatación (OR=6,00; IC 95%:4,02-8,95, empleo de epidural (OR=3,10;IC95%: 2,24-4,29 y necesidades de transfusión sanguínea (OR=3,33; IC 95%:1,70-9,67. Conclusiones: La IDP es un factor de riesgo para una mayor duración de la dilatación, empleo de analgesia epidural, necesidad de transfusión sanguínea y de cesárea tanto en mujeres nulíparas como en multíparas, especialmente en las indicaciones de gestación cronológicamente prolongada, registro cardiotocográfico patológico y estados hipertensivos del embarazo. No se encontró relación con la duración del período expulsivo, la práctica de episiotomía, desgarros, sangrado excesivo y rotura uterina.

  18. Normative study of tympanic infrared thermometry: a non-invasive index of asymmetric cerebral activity Normatização da termometria timpânica por infravermelho: um indicador não-invasivo de atividade cerebral assimétrica

    OpenAIRE

    Danielle Cicarini de Landa; Joaquim P. Brasil-Neto; Raphael Boechat-Barros; Carlos Uribe

    2008-01-01

    Human and primate studies have demonstrated that performance of tasks that induce asymmetrical physiological activation of the cerebral hemispheres leads to a reduction of tympanic temperature (TT) ipsilateral to the most active hemisphere. It is possible that diseases that interfere in an asymmetrical fashion with the degree of cerebral activity cause similar TT changes. There are not, however, normative studies of the acceptable interaural difference in TT in normal subjects at rest. This s...

  19. Midazolam por via oral como medicação pré-anestésica em crianças e adolescentes com paralisia cerebral: estudo comparativo das variações do índice bispectral Midazolam por vía oral como medicación preanestésica en niños y adolescentes con parálisis cerebral: estudio comparativo de las variaciones del índice bispectral Oral midazolam as pre-anesthetic medication in children and teenagers with cerebral palsy: a comparative study on the variations of the bispectral index

    Directory of Open Access Journals (Sweden)

    Verônica Vieira da Costa

    2009-02-01

    grupo de pacientes que presentan una serie de particularidades, con alteraciones inclusive en la región de la acción del midazolam. El objetivo del estudio fue evaluar la acción del midazolam utilizado como medicación preanestésica sobre el índice bispectral (EEG-BIS de los pacientes con parálisis cerebral. MÉTODO: Se evaluaron dos grupos de pacientes: uno con diagnóstico de PC y el otro sin enfermedad del sistema nervioso central (SNC y periférico. Se registraron valores de EEG-BIS en la enfermería en la víspera de la operación y el día de la operación, 40 minutos después de la administración de 0,6 mg.kg-1 de midazolam por vía oral. Quedaron excluidos pacientes con historial de reacción paradoxal al midazolam y pacientes del grupo control que estuviesen usando otra medicación. RESULTADOS: Se estudiaron 77 pacientes de ambos sexos, entre 4 y 18 años de edad. No hubo diferencia entre los valores de EEG-BIS basal entre los grupos estudiados. Después del uso del midazolam hubo una reducción de los valores del EEG-BIS en los dos grupos estudiados, con diferencia estadística significativa en cada grupo. En la comparación entre los grupos no hubo diferencia estadística. CONCLUSIONES: El midazolam administrado como medicación preanestésica en la dosis de 0,6 mg.kg-1 redujo los valores basales del EEG-BIS sin caracterizar la hipnosis y sin diferencia estadística en los grupos estudiados.BACKGROUND AND OBJECTIVES: Midazolam is a benzodiazepine with hypnotic action widely used as pre-anesthetic medication in pediatric anesthesia. Children with cerebral palsy (CP also benefit from the use of midazolam, but its effects on this group of patients, who present several particularities, including changes at the site of action of midazolam, are still unknown. The objective of this study was to evaluate the effects of midazolam, when used as pre-anesthetic medication, on the bispectral index (EEG-BIS of patients with cerebral palsy. METHODS: Two groups of

  20. Cerebral Arteriosclerosis

    Science.gov (United States)

    ... the brain can cause a hemorrhagic stroke. Both types of stroke can be fatal. Cerebral arteriosclerosis is also related to a condition known as vascular dementia, in which small, symptom-free strokes cause cumulative damage and death to neurons (nerve cells) in the brain. Personality changes in ...

  1. CIRUGÍA DE CATARATA POR MICROINCISIONES BIMANUALES Y COAXIALES

    Directory of Open Access Journals (Sweden)

    Juan Raúl Hernández Silva

    2012-03-01

    Full Text Available Objetivo: Comparar los resultados de la cirugía de catarata por las técnicas de microincisiones coaxiales y microincisiones bimanuales en el Instituto Cubano de Oftalmología “Ramón Pando Ferrer” en el período de junio de 2009 a junio de 2011. Métodos: Los pacientes fueron diagnosticados con catarata senil o presenil. De estos, 41 pacientes se operaron con la técnica de microincisiones coaxiales y 27 pacientes con la técnica de microincisiones bimanuales. Se determinó: edad, dureza del cristalino, agudeza visual mejor corregida y sin corrección preoperatoria y postoperatoria, media del astigmatismo inducido, pérdida celular endotelial, tiempo efectivo de ultrasonido y el equivalente esférico. Resultados: La mayoría de los pacientes tenían edades superiores a 50 años. Se empleó un tiempo efectivo de ultrasonido menor a un minuto para emulsificar el cristalino cataratoso, los cuales tenían una dureza para ambas técnicas ON3. El equivalente esférico se encontró según lo planificado en el preoperatorio para la emetropía. En el postoperatorio se obtuvo una corrección significativa del cilindro queratométrico y refractivo. Mejoró en su totalidad para ambas técnicas quirúrgicas, la mejor agudeza visual con corrección.  La media del astigmatismo inducido fue menor a 0,5 dioptrías, con una pérdida celular endotelial menor a un 5 %  en ambos grupos. Conclusiones: Para ambas técnicas quirúrgicas se logró resultados satisfactorios que demuestran la efectividad de las mismas.

  2. Entrenamiento de la capacidad aeróbica por medio de la terapia acuática en niños con parálisis cerebral tipo diplejía espástica

    OpenAIRE

    Fajardo, Nandy; Moscoso, Fabiola

    2013-01-01

    Los autores de este artículo pretenden identificar las características que debe tener una propuesta de intervención fisioterapéutica para el entrenamiento de la capacidad aérobica en niños y niñas entre los 8 y los 12 años, con parálisis cerebral tipo diplejía espástica, empleando la terapia acuática.

  3. El aumento del sodio intracelular inducido por la eliminación de calcio externo regula la movilidad del espermatozoide humano /

    OpenAIRE

    Torres Flores, Víctor Manuel

    2011-01-01

     tesis que para obtener el grado de Doctor en Ciencias Biológicas, presenta Víctor Manuel Torres Flores ; asesor Alberto Darszon Israel, Luis Manuel Montaño Ramírez, Juan Arcadio Molina Guarneros. 79 páginas : ilustraciones. Doctorado en Ciencias Biológicas UNAM, Facultad de Ciencias, 2011

  4. Estudio de los mecanismos del estrés replicativo inducido por la inhibición de la mavalonato difosfato descarboxilasa

    OpenAIRE

    Martín Sánchez, Covadonga

    2012-01-01

    Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de lectura: 13-07-2012 El requerimiento de colesterol para la proliferación de las células de mamíferos está bien establecido. En nuestro laboratorio se había demostrado que el colesterol era nec esario para la correcta transición de la fase G2 a M en el ciclo celular y para la citocinesis. Cuando se tratan con altas dosis de estatinas, inhibidores ...

  5. Changes in the chromogen properties of the betalaine induced by gamma radiation; Cambios en las propiedades cromogenas de las betalainas inducidos por radiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez N, S.; Pinedo S, A.; Amador V, P.; Chacon R, A.; Arcos P, A.; Vega C, H.R. [Unidad Academica de Ciencias Nucleares, C. Cipres 10, Fracc. La Penuela, 98068 Zacatecas (Mexico)

    2005-07-01

    The changes of coloration of four natural extracts in function of the absorbed dose produced by a gamma rays source of {sup 137} Cs were determined. The natural extracts used contain betalaines that are natural pigments of some plants as the beet about that their name. They are also in abundant form in the fruits (tunas) of some species of the Opuntia genus. The extracts were obtained by maceration, starting from beet and three tuna varieties, and they were stabilized to pH 5.5 The change of coloration it was determined in a visible ultraviolet spectrophotometer by means of the absorbance from the samples to photons of 475, 535 and 600 nm of wavelength. The absorbance to different intervals of time was measured. The relationship between the absorbed dose and the chromogene properties of the pigment, with the intention of using it as possible dosemeter was settled down. (Author)

  6. Obtention of zinc polymethacrylate via free radicals induced by gamma radiation; Obtencion del polimetacrilato de zinc via radicales libres inducidos por radiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Urena N, F.; Flores E, J. [Departamento de Fisica, Instituto Nacional de Investigaciones Nucleares, C.P. 52045 Estado de Mexico (Mexico)

    2000-07-01

    The objective of this work was to synthesise the monomer of zinc methacrylate and subsequently to carry out the polymerization reaction with the purpose to obtain the compound desired, the zinc polymethacrylate. For this it was used a gamma radiation source, {sup 60} Co, as initiator of the polymerization reaction. (Author)

  7. Anti mutagenesis of chemical modulators against damage induced by reactor thermal neutrons; Antimutagenesis de moduladores quimicos contra el dano inducido por neutrones termicos de reactor

    Energy Technology Data Exchange (ETDEWEB)

    Zambrano A, F.; Guzman R, J.; Garcia B, A.; Paredes G, L.; Delfin L, A. [Instituto Nacional de Investigaciones Nucleares, Departamentos de Materiales Radiactivos, de Biologia, del Reactor y Gerencia de Aplicaciones Nucleares en la Salud, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1999-07-01

    The mutations are changes in the genetic information whether for spontaneous form or induced by the exposure of the genetic material to certain agents, called mutagens: chemical or physical (diverse types of radiations). As well as exist a great variety of mutagens and pro mutagens (these last are agents which transform themselves in mutagens after the metabolic activation). Also several chemical compounds exist which are called antimutagens because they reduce the mutagens effect. The C vitamin or ascorbic acid (A A) presents antimutagenic and anti carcinogenic properties. On the other hand a sodium/copper salt derived from chlorophyll belonging to the porphyrin group (C L) contains a chelated metal ion in the center of molecule. It is also an antioxidant, antimutagenic and anti carcinogenic compound, it is called chlorophyllin. The objective of this work is to establish if the A A or the C L will reduce the damages induced by thermal and fast reactor neutrons. (Author)

  8. Efectos de la quercetina sobre las alteraciones en el comportamiento y estrés oxidativo inducidos por rayos X en ratas

    OpenAIRE

    Marina Hernández, Raquel

    2013-01-01

    271 p. El trabajo es un estudio in vivo del efecto radiomodificador de la quercetina para contribuir a definir su potencial aplicación a la radioterapia, incluyendo como variable a considerar el intervalo de tiempo transcurrido desde la administración de radiación. Debido a los efectos deletéreos de la radiación ionizante sobre el sistema nervioso y el hígado, entre otros, es interesante llevar a cabo estudios sobre el efecto radiomodificador relativos al comportamiento y la fisiología en...

  9. Inhibitory action of chlorophyllin of autosome recessive lethals induced by irradiation; Accion inhibidora de la clorofilina de letales recesivos autosonicos inducidos por irradiacion

    Energy Technology Data Exchange (ETDEWEB)

    Salceda, V.M.; Pimentel, P.A.E.; Cruces, M.P. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)]. e-mail: vmss@nuclear.inin.mx

    2006-07-01

    The chlorolin is a sodium salt of the chlorophyll that has a strong protective action of the damage induced by different agents so much physical as chemical. In Drosophila there is reported this effect in somatic cells. In contrast, in germinal cells using tests with the sexual chromosomes has not been found such inhibitory action. For this reason, in this occasion we will refer to the effect of the lethality induced in autosome chromosomes, in particular to the chromosome II of this species. For such effect groups of males of the line Canton-S its were pre-treated for 24h with or without 69 mm of CCS and later on treaties with or without 40 Gy of gamma irradiation. The males were then subjected to the technical Cy L / Pm for the detection of recessive lethals. In the third generation the respective counts of the descendant of each one of them to determine the corresponding categories for each extracted chromosome were made. To be mendelian crosses it is expected for a normal chromosome a proportion 2:1 of individuals with genotype Cy L / +: +/+. The absence of individuals +/+ it is indicative of a lethal gene, until 10% of these individuals of each male's total descendant, it is considered that is carrying of a semi lethal gene. The sum of lethal and semi lethals constitutes the category detrimental. The obtained results indicated that the pre-treatment with CCS reduces in a significant way the frequency of induced lethals by 40 Gy of gamma rays. The fact that an effect inhibitor has not been observed in the test of recessive lethal bound to the sex obtained previously, it contrasts with the effect observed in the chromosome II, results of this study and with the one observed in the chromosome III in somatic cells. The above-mentioned shows a differential action of the CCS between sexual chromosomes and autosomal before the effect of the gamma radiation. At the moment we don't have an explanation to these evidences. To evaluate the action of the chlorophyllin on the damage caused by the radiation, it was into accothe presence of lethal and semi lethals autosomal. One observes this way that even without the use of the radiation the semi lethals frequency is diminished when the chlorophyllin is applied, in this case the decrease was significant and although there was decrease in the case of the irradiated group this it was not significant; in the case of the lethal ones it happened the opposite it was not significant in radiation absence on the contrary elevate the frequency of this type of genes, however, before the radiation and with pre-treatment with chlorophyllin this it reduced the frequency of autosomal recessive lethals significantly. This is important because in the case of bound recessive lethals recessive to the sex this doesn't happen. (Author)

  10. Evaluation of defects induced by neutron radiation in reactor pressure vessels steels; Evaluacion de los defectos inducidos por la radiacion neutronica en los aceros de vasijas

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Jimenez, J.

    1978-07-01

    We have developed a method for calculating the production of neutron induced defects (depleted zone and crowdions) in ferritic pressure vessel steels for different neutron spectra. They have been analysed both the recoil primary atoms produced by elastic and inelastic collisions with fast neutrons and the ones produced by gamma-ray emission by thermal neutron absorption. Theoretical modelling of increasing in the ductile-brittle transition temperature of ferritic steels has been correlated with experimental data at irradiation temperature up to 400 degree centigree (Author) 15 refs.

  11. Evaluación de parámetros citogenéticos inducidos por extractos acuosos de siete plantas usadas como agentes antihipertensivos en medicina popular argentina

    OpenAIRE

    Amat, Anibal Gumersindo; Yajia, Marta Esther; González, Claudio F.; Lorca, Graciela L.; Sánchez Gonzalez, Felipa; Riglos, Ana G.; Verón, José R.

    2002-01-01

    Han sido estudiados los extractos acouosos de siete especies utilizadas en el NE de Argentina para el tratamiento de la hipertensión, con el propósito de evaluar su acción sobre la mitosis como indicador de presunción de actividad antimitótica o genotóxica, usando el test de Allium cepa. Los resultados mostraron una disminución del índice mitótico en todas las especies estudiadas, pero la acción antimitótica fue estadísticamente significativa sólo en el caso de los extractos de Aristolochi...

  12. Employees with Cerebral Palsy

    Science.gov (United States)

    ... Resources Home | Accommodation and Compliance Series: Employees with Cerebral Palsy (CP) By Eddie Whidden, MA Preface Introduction Information ... SOAR) at http://AskJAN.org/soar. Information about Cerebral Palsy (CP) What is CP? Cerebral palsy is a ...

  13. Sepsis por shigella flexneri

    Directory of Open Access Journals (Sweden)

    César Cabrera C

    2005-04-01

    Full Text Available Se presenta un caso raro de sepsis por Shigella flexneri en una paciente de 45 años de edad quien estando hospitalizada para el estudio de un tumor cerebral, requirió el uso de manitol y dosis altas de corticoides; luego de ello presenta deposiciones líquidas con moco y sangre, desarrolla síndrome de respuesta inflamatoria sistémica, luego se aísla Shigella flexneri en el hemocultivo; recibió tratamiento antibiótico con ciprofloxacina. Se describen las características del caso y se comenta de acuerdo con la revisión de literatura.

  14. Parálisis cerebral Cerebral palsy

    Directory of Open Access Journals (Sweden)

    Jorge Malagon Valdez

    2007-01-01

    Full Text Available El término parálisis cerebral (PC engloba a un gran número de síndromes neurológicos clínicos, de etiología diversa. Estos síndromes se caracterizan por tener una sintomatología común: los trastornos motores. Algunos autores prefieren manejar términos como "encefalopatía fija", "encefalopatías no evolutivas". Se mencionan la utilidad de programas de intervención temprana y métodos especiales de rehabilitación, así como el manejo de las deficiencias asociadas como la epilepsia, deficiencia mental, trastornos del lenguaje, audición, visión, déficit de la atención que mejoran el pronóstico de manera significativa. El pronóstico también depende de la gravedad del padecimiento y de las manifestaciones asociadas.The term cerebral palsy (CP, is used for a great number of clinical neurological syndromes. The syndromes are characterized by having a common cause, motor defects. It is important, because they can cause a brain damage by presenting motor defects and some associated deficiencies, such as mental deficiency, epilepsy, language and visual defects and pseudobulbar paralysis, with the nonevolving fact. Some authors prefer using terms such as "non-evolving encephalopathies". In the treatment the utility of prevention programs of early stimulation and special rehabilitation methods, and treatment of associated deficiencies such as epilepsy, mental deficiency, language, audition and visual problems, and the attention deficit improve the prognosis in an important way. The prognosis depends on the severity of the disease and the associated manifestations.

  15. Ca2+-ATPasa y Muerte Celular Inducida por Ca2+ en células Cardíacas H9c2

    OpenAIRE

    Lax Pérez, Antonio Manuel

    2009-01-01

    La Ca2+-ATPasa de RS puede hidrolizar ATP a través de una ruta alternativa en la que solo intervienen conformaciones de la proteína que no unen Ca2+. El mecanismo molecular de esta actividad hidrolítica implica un cambio conformacional inducido por ATP que produce aproximaciones de los dominios citosólicos. El uso de indicadores fluorescentes y compuestos que movilizan Ca2+ permite caracterizar flujos y depósitos intracelulares de Ca2+ que están implicados en la generación de señales intracel...

  16. Cerebral palsy

    International Nuclear Information System (INIS)

    This paper reviews cranial MR findings in patients with cerebral palsy (CP) to clarify and categorize this disorder. The MR images of 40 patients with clinical CP were retrospectively reviewed. All patients suffered either varying spastic plegias, hypotonicity, or choreoathetosis. Concomitantly, the patients suffered from static encephalopathy, developmental delay, and/or microcephaly. Twenty-four patients were born at or near term, 10 were premature, and incomplete birth histories were available in six. The MR images revealed mild to severe degrees of white matter damage in 24 patients (12 term, nine premature, three unknown)

  17. Cerebral malaria.

    Science.gov (United States)

    Postels, Douglas G; Birbeck, Gretchen L

    2013-01-01

    Malaria, the most significant parasitic disease of man, kills approximately one million people per year. Half of these deaths occur in those with cerebral malaria (CM). The World Health Organization (WHO) defines CM as an otherwise unexplained coma in a patient with malarial parasitemia. Worldwide, CM occurs primarily in African children and Asian adults, with the vast majority (greater than 90%) of cases occurring in children 5 years old or younger in sub-Saharan Africa. The pathophysiology of the disease is complex and involves infected erythrocyte sequestration, cerebral inflammation, and breakdown of the blood-brain barrier. A recently characterized malarial retinopathy is visual evidence of Plasmodium falciparum's pathophysiological processes occurring in the affected patient. Treatment consists of supportive care and antimalarial administration. Thus far, adjuvant therapies have not been shown to improve mortality rates or neurological outcomes in children with CM. For those who survive CM, residual neurological abnormalities are common. Epilepsy, cognitive impairment, behavioral disorders, and gross neurological deficits which include motor, sensory, and language impairments are frequent sequelae. Primary prevention strategies, including bed nets, vaccine development, and chemoprophylaxis, are in varied states of development and implementation. Continuing efforts to find successful primary prevention options and strategies to decrease neurological sequelae are needed. PMID:23829902

  18. Acute ischemic cerebral attack

    Directory of Open Access Journals (Sweden)

    Franco-Garcia Samir

    2010-12-01

    , statins. Some specific cases will need carotid endarterectomy, management of arrhythmia like atrial fibrillation and the study of secondary causes of cerebrovascular illness. Of the same value is the early begining of measures leading to achieve the rehabilitation and integration of the patient to the society within theses they are the interdisciplinary management with nutrition, phonoaudiology, physic therapy, psicology and others specialities. The ACS is a patology that require a multidisciplinayr and geared work to a chieve and impact in the society.RESUMENLa disminución del flujo sanguíneo cerebral por debajo del umbral de autoregulación conlleva a cambios de isquemia y necrosis cerebral, que se traducen en síntomas de disfunción neurológica focal llamado ataque cerebrovascular agudo (ACA o ictus. Dos grandes grupos según su etiología se incluyen en esta categoría el hemorrágico que constituye un 20% y el isquémico en 80% de los casos. Gran interés ha ganado el ACA isquémico por su alta carga social, siendo la tercera causa de muerte no violenta a nivel mundial y la primera de discapacidad. Muchos factores de riesgo favorecen lapresentación de estos eventos y algunos de ellos son susceptibles de modificación y por tanto se constituyen en objetivos de prevención primaria tales como el control de la diabetes, hipertensión y la práctica de hábitos saludables de vida. Los avances en el conocimiento de la fisiopatología, han llevado a cambios sustanciales en la nomenclatura y manejo del ACA isquémico. Dentro de estos cambios se sustituyó el término accidente cerebrovascular por ataque cerebrovascular agudo, haciendo énfasis en la importancia de un manejo oportuno con metas de tiempo similar al sindrome coronario agudo. Se redefinió el tiempo de ataque isquémico transitorio a una hora. Una vez instaurado el evento cerebrovascular la semiología de los síntomas con frecuencia nos permitirá realizar un diagnóstico topográfico de la lesión, que

  19. Cerebral cysticercosis

    International Nuclear Information System (INIS)

    Two cases of histologically proven cerebral cysticercosis are presented. In both cases subcutaneous tissue nodules, a rare feature, were present. Several disease patterns are apparent - meningeal, parenchymatous and ventricular, spinal cord lesions and mixed patterns. Epilepsy is by far the major presenting symptom of cysticercosis, which in turn plays a significant role in the causation of adult-onset epilepsy in Blacks. Despite its drawbacks, the haemag-glutination inhibition test remains the most satisfactory serological method at present available for the diagnosis of cysticercosis; it is positive in up to 85% of cases of proven cysticercosis. With the advent of computed tomography many cases of unsuspected cysticercosis (symptomatic or asymptomatic) are being discovered

  20. por valores

    Directory of Open Access Journals (Sweden)

    Jazmín Díaz-Barrios

    2005-01-01

    Full Text Available La era actual se caracteriza por una búsqueda de la identidad del hombre, donde el pivote del cambio organizacional es el individuo; cambiar en este entorno depende, en gran medida, de los valores que imperen en la cultura de la organización. Este trabajo documental intenta identificar aquellos valores, condición sine-qua-non, para el logro de los objetivos de cambio y analizarlos a fin de determinar sus indicadores, con el objeto de presentar una herramienta a las organizaciones que les facilite adaptarse a los nuevos tiempos. Se encontró que los valores: Delegación, Comunicación, Colaboración, Participación y Aprendizaje, son esenciales en los cambios integrales de esta era. Se determinaron 20 indicadores de su presencia. Se concluye que con esta información cada ente puede elaborar instrumentos que le permitan saber si los valores requeridos están presentes y en caso contrario tomar decisiones que alineen a la organización alrededor de los valores humanistas planteados, incrementando así las posibilidades de éxito en el proceso de cambio y por ende, las posibilidades de supervivencia en esta nueva época.

  1. Paralisia Facial Periférica por comprometimento do tronco cerebral: A propósito de um caso clínico Peripheral Facial Paralisys of brainstem origin: A clinical case description

    Directory of Open Access Journals (Sweden)

    Paulo R. Lazarini

    Full Text Available É apresentado um caso clínico de paciente portador de paralisia facial periférica com comprometimento de toda a hemiface direita. Durante a investigação clínica, esperava-se que o comprometimento topográfico do nervo facial se desse a partir de sua emergência na ponte. Após exames de imagem, evidenciou-se lesão expansiva no tronco cerebral. Deste modo, a classificação de paralisia facial como periférica ou central não atende a este caso. O uso de uma classificação utilizando os núcleos do nervo facial como referência pode ser mais adequado na investigação clínica da paralisia facial.It is presented a clinical case of a patient with a peripheral facial paralysis with hemifacial compromise. During the clinical investigation it was expected that the topographic compromise of the facial nerve would arise out of the emergence of the nerve from the pons. After some image examinations, an expansive brain trunk lesion was evidenced. Thus, the classification of facial paralysis - either peripheral or central - is not applicable to this case. The use of a classification having the facial nerve nucleus as reference could be more adequate in the clinical investigation of the paralysis.

  2. Características clínicas y fármacos recibidos por los pacientes con diagnóstico de Parkinson.

    Directory of Open Access Journals (Sweden)

    Tomás Zamora

    2009-10-01

    Full Text Available Se realizó un estudio descriptivo retrospectivo en los pacientes remitidos por alteraciones motoras, atribuidas a enfermedad de Parkinson desde enero, 1995 a junio, 1999 en el Hospital Universitario San José y en el Centro de Atención Ambulatoria del Instituto de Seguro Social, Cauca. Se encontraron 19 casos de parkinsonismo por calcioantagonistas. Se hace énfasis en la presentación clínica y en la importancia de buscar antecedentes sobre fármacos prescritos y factores asociados con el fenómeno o trastorno motor. Se presentan resultados, se discuten los hallazgos clínicos y se revisa la literatura del parkinsonismo inducido por calcioantagonistas.

  3. United Cerebral Palsy

    Science.gov (United States)

    ... be sure to follow us on Twitter . United Cerebral Palsy UCP educates, advocates and provides support services to ... Partners Merz Logo Sprint Relay Copyright © 2015 United Cerebral Palsy 1825 K Street NW Suite 600 Washington, DC ...

  4. Cerebral palsy and epilepsy

    OpenAIRE

    Knežević-Pogančev Marija

    2010-01-01

    Introduction. Cerebral palsy is the most common cause of physical disability in early childhood. Epilepsy is known to have a high association with cerebral palsy. All types of epileptic seizures can be seen in patients with cerebral palsy. Complex partial and secondary generalized ones are the most frequent seizure types. In persons with cerebral palsy and mental retardation, the diagnosis of epilepsy presents unique difficulties. Generally they are not able to describe the epileptic ev...

  5. Cerebral microangiopathies; Zerebrale Mikroangiopathien

    Energy Technology Data Exchange (ETDEWEB)

    Linn, Jennifer [Klinikum der Universitaet Muenchen (Germany). Abt. fuer Neuroradiologie

    2011-03-15

    Cerebral microangiopathies are a very heterogenous group of diseases characterized by pathological changes of the small cerebral vessels. They account for 20 - 30 % of all ischemic strokes. Degenerative microangiopathy and sporadic cerebral amyloid angiography represent the typical acquired cerebral microangiopathies, which are found in over 90 % of cases. Besides, a wide variety of rare, hereditary microangiopathy exists, as e.g. CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), Fabrys disease and MELAS syndrome (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes). (orig.)

  6. Analysis of the problems of induced draft fans in a carbo-electric power station; Analisis de la problematica de ventiladores de tiro inducido de una central carboelectrica

    Energy Technology Data Exchange (ETDEWEB)

    Diaz Sanchez, Valentin de Jesus; Vital Flores, Francisco [LAPEM, Comision Federal de Electricidad (Mexico)

    2007-11-15

    The induced draft fans of the 350 MW units of a Thermo-electric power plant presented problems consisting of the failure of the capacity of gases extraction, together with the presence of cracks in the blades; this condition was observed since the stage of putting into service. Consequently, losses have been originated in the availability in two units, as well as, losses due to the manufacture of new impellers, which also originated that, in some cases, that the measures of the impellers, locally manufactured, differed from the originals, resulting in differences in the unit's efficiency. [Spanish] Los ventiladores tiro inducido de las unidades de 350 MW de una Central Termoelectrica presentaban una problematica consistente en la falla de capacidad de extraccion de gases, aunado a la presencia de fracturas en las aspas de los impulsores, esta condicion se observo desde la etapa de puesta en servicio. En consecuencia se han ocasionado perdidas de disponibilidad en dos unidades, asi como tambien, perdidas debido a la fabricacion de nuevos impulsores, lo que tambien origino que, en algunos casos, las medidas de los impulsores, fabricados localmente, diferian de los originales, dando como resultado diferencias en la eficiencia de las unidades.

  7. [Therapeutic potential of bone marrow stem cells in cerebral infarction].

    Science.gov (United States)

    Sánchez-Cruz, Gilberto; Milián-Rodríguez, Lismary

    2015-05-16

    Introduccion. Las celulas madre constituyen una alternativa terapeutica que se encuentra en fase de experimentacion para el infarto cerebral. Objetivo. Mostrar la evidencia cientifica existente sobre el potencial terapeutico de las celulas madre de la medula osea en esta enfermedad. Desarrollo. El infarto cerebral representa el 80% de las enfermedades cerebrovasculares. La trombolisis constituye la unica terapia aprobada, pero, por su estrecha ventana terapeutica, solo se aplica a un bajo porcentaje de los pacientes. De manera alternativa, los tratamientos neurorrestauradores, como el de celulas madre, pueden aplicarse en periodos mas prolongados. Por esta razon se efectuo una busqueda bibliografica en PubMed con el empleo de las palabras clave 'stem cells', 'bone marrow derived mononuclear cells' y 'stroke'. Se encontraron evidencias de seguridad y eficacia de dichas celulas en diferentes momentos evolutivos del infarto cerebral. Se identificaron estudios que en clinica y preclinica las recolectaron por puncion medular y en sangre periferica, y las trasplantaron directamente en el area infartada o por via intravascular. El efecto terapeutico se relaciona con sus propiedades de plasticidad celular y liberacion de factores troficos. Conclusiones. El concentrado de celulas mononucleares autologas, obtenido en sangre periferica o por puncion de la medula osea, y trasplantado por via intravenosa, es una factible opcion metodologica que permitira rapidamente incrementar el numero de ensayos clinicos en diferentes etapas evolutivas del infarto cerebral. Esta terapia muestra seguridad y eficacia; sin embargo, deben ampliarse las evidencias que avalen su generalizacion en humanos.

  8. Insulina cerebral

    Directory of Open Access Journals (Sweden)

    Andrés Jagua

    2008-03-01

    Full Text Available La insulina es una hormona con efectos sobre el metabolismo y crecimiento normal de muchas células del cuerpo. En las últimas décadas se han descubierto, además, sus efectos sobre funciones del sistema nervioso central: modulación del ciclo apetito-saciedad, función reproductiva, liberación de neurotransmisores, supervivencia neuronal y plasticidad sináptica. Las evidencias obtenidas desde modelos animales y hallazgos neuropatológicos han permitido entender parte de los mecanismos que asocian a la señal de la insulina con enfermedades neurodegenerativas como la enfermedad de Alzheimer. En este artículo se revisarán las acciones de la insulina sobre el hipotálamo, la supervivencia neuronal, la plasticidad sináptica y por último, las implicaciones de estos conocimientos en la comprensión de procesos degenerativos del sistema nervioso central como la enfermedad de Alzheimer.

  9. Desigualdades entre pacientes hospitalizados por doenças cardíacas e vasculares-cerebrais em localidade do Estado de São Paulo (Brasil, 1986 Inequalities among patients hospitalized for cardiac and cerebral-vascular diseases in the City of the State of S. Paulo, Brazil, 1986

    Directory of Open Access Journals (Sweden)

    Juan Stuardo Yazlle Rocha

    1989-10-01

    Full Text Available Valendo-se de um sistema de informações sobre hospitalizações no Município de Ribeirão Preto, SP (Brasil foram estudadas as características clínico-epidemiológicas referidas dos pacientes internados, em 1986, por doenças cardíacas e vasculares-cerebrais (DCVC. De 43.499 hospitalizações ocorridas naquele ano, 4.673 foram ocasionadas por doenças cardíacas e vasculares-cerebrais. Utilizando a fonte de financiamento da internação como indicador do estrato social ao qual pertence o paciente, foram compostos 4 grupos de estudo: particulares, "outros", previdenciários e "não pagantes"; estes grupos apresentaram diferenças significativas quanto a coeficiente de internações por DCVC, média e mediana de idade na hospitalização, perfil ocupacional, duração da internação, freqüência dos sub-grupos diagnósticos, coeficientes de mortalidade e a idade média e mediana nos casos de óbitos. Estas diferenças foram atribuídas às disparidades sociais no nível de vida e condições de trabalho dos grupos estudados o que determina diferenças no adoecer, ser assistido e no morrer.The clinical and epidemiological characteristics of hospitalizations due to cardiac and cerebral-vascular diseases (CCVD - ICD 390 - 438, which occurred in 1986, were studied on the basis of data from an information system relating to medical care in the City of Ribeirão Preto, State of S. Paulo, Brazil. These causes accounted for 4,673 of the annual total of 43,449 hospital admissions. Using the sources of payment of the hospitalization as an indicator of the patients' social strata, the following four study groups were defined: private, social insurance, non-paying and "others". These groups showed significant differences in relation to the following variables: hospitalization rates due to CCVD, mean and median age at admission and time of death, occupation, average length of stay in the hospital, mortality rates and relative frequencies of specific

  10. Modulación de la actividad dopa-decarboxilasa central evaluada mediante PET con 18-F-dopa inducida por la administración crónica de levodopa en macacos con parkinsonismo inducido por MPTP

    OpenAIRE

    M. Riverol; Luquin, M R

    2013-01-01

    La enfermedad de Parkinson (EP) es una entidad frecuentre que afecta fundamentalmente a personas de edad avanzada. Los fármacos más utilizados para el control de los síntomas de esta entidad son la levodopa y los agonistas dopaminérgicos. Diversos estudios de tomografía de emisión de positrones (PET) con 18F-fluorodopa y DAT-scan realizados en pacientes tratados han mostrado, que tras 5 años dde tratamiento, la actividad dopa-descarboxilasa y del transportador de dopamina, fue mayor en los pa...

  11. Desempeño reproductivo del bocachico (Prochilodus magdalenae, Steindachner, 1878) inducido en un mismo año.

    OpenAIRE

    Mar P., Elkin; Petro M., Roberto; Atencio G, Víctor

    2003-01-01

    Prochilodus magdalenae es la principal especie pesquera continental y la cuarta cultivada en Colombia. En su ambiente natural se reproduce en el cauce principal de los ríos, en el período lluvioso y lo hace una sola vez al año. No se reproduce en confinamiento por lo que la obtención de semillas para los programas de repoblamiento y fomento piscícola se obtienen mediante inducciones hormonales, principalmente con extracto pituitario de carpa (EPC). Para mantener la oferta de alevi...

  12. Cerebral angiography in leptomeningitis and cerebritis

    International Nuclear Information System (INIS)

    This is a report of the cerebral angiographic findings in cases of meningitis and cerebritis. Fifty-nine patients, 38 of whom were under 1 year of age, underwent cerebral angiography by means of femoral catheterization. All the patients had signs of increased intracranial pressure, seizures, focal cerebral signs, positive transillumination of the head, and or abnormal brain scan findings. A few patients who did not respond to systemic antibiotics as was expected were also evaluated by means of cerebral angiography. The following characteristic angiographic findings were observed in 18 cases of active meningitis: (1) A hasy appearance around the arteries (halo formation) between the late arterial and capillary phases. (2) Narrowing of the arteries in the basal cistern. This sometimes extended to the peripheral arteries. (3) Irregular caliber following the narrowing of arteries (in few cases). (4) Circulation time so slow that veins could be seen in the late arterial phase. (5) Halo formation around the anterior chroidal artery and the clear appearance of the choroid plexus in the venous phase (when the infectious process reached the choroid plexus). Cerebritis could be identified on the angiograms by two signs: (1) local swelling of the brain (mainly the temporal lobe) and (2) staining around the veins without any abnormal signs in the arterial phase (laminar staining). In conclusion, angiography is a meaningful test by which to determine the phase of meningitis and cerebritis. These two conditions should be treated based on valid information obtained by means of CSF examinations and neuroradiological tests, especially CT scan and cerebral angiography. (author)

  13. La inundación de octubre de 1879 en el Bajo Segura. Magnitud y efectos inducidos

    Directory of Open Access Journals (Sweden)

    Calvo García-Tornel, F.

    2001-03-01

    Full Text Available This article constitutes a approach in the analysis of the catastrophic flood occurred on October 1875 in the Guadalentin Basin and Lower Segura river. In first place, event implications within scientist, political and socioeconomic contexts areis described, as well as the magnitude of the same, valued in terms of material damages and morphological effects. Next the physical factors that contributes to the disaster are studied, revising the pluviométric and hydrological data and deducing another new (kinetic energy of the rain, rainfall erosivity, hydraulic parameters for the methods of Manning and MEI. Finally the situation of the basin in relation to the risk is shown, emphasizing the effects derived of the works of defense and other civil structures like an clear indicator of the environmental fragility imposed for the human action.

    Este artículo constituye una nueva aproximación en el análisis de la catastrófica inundación ocurrida los días 14 y 15 de octubre de 1875 en la cuenca del Guadalentín y vegas media y baja del Segura, dedicando especial atención a esta última, por su extraordinaria gravedad y mayor grado de información. En primer lugar se describe la trascendencia del suceso dentro de los ámbitos científico, político y socio-económico, así como la magnitud del mismo, valorada en términos de daños materiales y efectos geo- morfológicos. A continuación se estudian los factores físicos que contribuyeron a la catástrofe, haciendo una revisión de los datos pluviométricos e hidrológicos existentes y deduciendo otros nuevos (energía cinética de la lluvia, erosividad pluvial, obtención de parámetros hidráulicos por los métodos de Manning y MEI. Finalmente se muestra la situación de la cuenca ante el riesgo, destacando los efectos derivados de las obras de defensa y de otras infraestructuras como un claro indicador de la fragilidad de este medio impuesta por el hombre.

  14. Estudio histopatológico e inmunohistoquímico de páncreas en perros diabéticos inducidos con aloxano Histopathologic and immunohistochemical study of pancreas in alloxan-induced diabetic dogs

    Directory of Open Access Journals (Sweden)

    V Cubillos

    2008-01-01

    Full Text Available El presente estudio se llevó a cabo en perros diabéticos tipo I inducidos con Aloxano®, con el propósito de evaluar las lesiones microscópicas presentes en páncreas y relacionarlas con la presencia o ausencia de insulina en los islotes de Langerhans a distintos tiempos posinducción. Se utilizaron 20 caninos mestizos, machos enteros de 4 a 7 años de edad, los cuales fueron divididos en 2 grupos: Control (n = 5 y Experimental (n = 15. Este último fue subdividido en grupos de 3 animales cada uno y sometido a la inducción de Diabetes mellitus mediante la administración e. v. de Aloxano® en dosis única de 75 mg/kg. Los animales fueron sacrificados a distintos tiempos posinducción (p.i.: 2h, 24hy 7d, 14d, 21d, tomándose muestras de páncreas para examen histopatológico e inmunohistoquímico para determinar insulina y Ki-67. Para cada subgrupo experimental se consideró un perro Control. El estado diabético del Grupo Experimental se comprobó mediante la evaluación de glucosa y fructosamina en plasma. La diabetes fue confirmada por la instauración de hiperglicemia sostenida e hiperfructosaminemia a partir de los 7 días p.i. Los resultados histopatológicos mostraron una disminución significativa (P The aim of this study was to evaluate pancreatic microscopic lesions with the presence or absence of insulin in Langerhans islets at different times post-induction (p.i. in alloxan-induced diabetic type I dogs. A group of 20 mixed breed, male adult dogs were used, subdivided in 2 groups: Control (n = 5 and Experimental (n = 15. The Experimental Group was subdivided into groups of 3 animals each which were alloxan-induced intravenously (75 mg/kg. Dogs were sacrificed at different times p.i. (2 hours, 24 hours, 7 days, 14 days, 21 days. Pancreatic samples were taken for histopathologic and immunohistochemical study against insulin and Ki-67. The Control Group considered 5 healthy dogs, one for each Experimental Group. Plasmatic evaluation

  15. Statins and cerebral hemodynamics

    Science.gov (United States)

    Giannopoulos, Sotirios; Katsanos, Aristeidis H; Tsivgoulis, Georgios; Marshall, Randolph S

    2012-01-01

    HMG-CoA reductase inhibitors (statins) are associated with improved stroke outcome. This observation has been attributed in part to the palliative effect of statins on cerebral hemodynamics and cerebral autoregulation (CA), which are mediated mainly through the upregulation of endothelium nitric oxide synthase (eNOS). Several animal studies indicate that statin pretreatment enhances cerebral blood flow after ischemic stroke, although this finding is not further supported in clinical settings. Cerebral vasomotor reactivity, however, is significantly improved after long-term statin administration in most patients with severe small vessel disease, aneurysmal subarachnoid hemorrhage, or impaired baseline CA. PMID:22929438

  16. Factors associated with chloroquine induced pruritus during malaria treatment in Mozambican University students Factores asociados a la aparición de prurito por cloroquina durante el tratamiento de la malaria en estudiantes universitarios de Mozambique

    Directory of Open Access Journals (Sweden)

    Helena Gama

    2009-08-01

    Full Text Available Introduction: It has been suggested that reductions in chloroquine use may be followed by a resurgence of chloroquine-susceptible falciparum malaria, and chloroquine might once again be an effective treatment choice, which renews the importance of aspects related to its use and misuse. Therefore, we aimed to estimate the prevalence of chloroquine-induced pruritus and to identify risk factors for its occurrence in Mozambican University students. Methods: A cross-sectional study was conducted at a private University in Maputo. Students were approached in the classrooms to complete a self-administered questionnaire covering sociodemographic characteristics, number of previous malaria episodes, utilization of antimalarial drugs, and life prevalence of chloroquine induced pruritus. Results: Among 795 respondents, 77.4% (601/777 reported at least one malaria episode and 73.2% (542/740 had used chloroquine before. The life-prevalence of chloroquine-induced pruritus was 30.1% (158/525. Pruritus tended to be more frequent when chloroquine was used for treatment compared with prophylaxis only (31.2% vs. 10.3%, pIntroducción: Se ha sugerido que la reducción en el uso de la cloroquina puede derivar en el resurgimiento de la malaria falciparum sensible a la cloroquina, por lo que ésta puede volver a ser un tratamiento efectivo de elección, renovando la importancia de aspectos relacionados con su uso y su mal uso. Se pretende estimar la prevalencia de prurito inducido por cloroquina e identificar los factores de riesgo asociados a su ocurrencia en estudiantes universitarios de Mozambique. Métodos: Se realizó una encuesta transversal en una Universidad privada de Mozambique. Los estudiantes fueron abordados en las aulas para completar un cuestionario autoadministrado, que contenía datos sociodemográficos e información sobre el número de episodios previos de malaria, la utilización de fármacos antipalúdicos y la prevalencia de prurito inducido por

  17. Botulinum-A toxin in the treatment of painful post-stroke nocturnal paroxysmal dystonia triggered by periodic limb movements of sleep: case report Toxina botulínica tipo A no tratamento da distonia paroxística noturna dolorosa pós-isquemia cerebral desencadeada por movimentos periódicos do sono: relato de caso

    Directory of Open Access Journals (Sweden)

    Pedro A. Kowacs

    2006-12-01

    Full Text Available INTRODUCTION: Sleep disorders presenting involuntary movements may be very annoying to patients, apart from their negative influence on sleep. OBJECTIVE: To report the use of botulinum type-A toxin (BoNT-A to manage the case of a patient whose sleep was severely disrupted by episodes of dystonic posturing of the right lower limb triggered by periodic limb movements of sleep (PLMS. METHOD: A 79-year-old woman with mild post-stroke right hemiparesis presented with recurrent painful episodes of dystonia of the right lower limb, which disrupted her sleep. The dystonic episodes could also be voluntarily triggered by extension of the right hallux. Polysomnography confirmed that the dystonic episodes were triggered by PLMS. Twenty units of BoNT-A (20U/500U vial were injected into her right extensor hallucis longus. RESULTS: Shortly after BoNT-A was injected, the dystonic symptoms abated, and the patient achieved better sleep efficiency. CONCLUSION: The PLMS-related involuntary extension of the hallux was probably triggering the nocturnal post-stroke lower limb dystonic paroxysms. BoNT-A injection into the right extensor hallucis longus was effective in managing this condition and thus resolved the associated disruption of sleep.INTRODUÇÃO: Desordens do sono apresentando movimentos involuntários podem ser bastante perturbadoras aos pacientes, além de sua influência negativa no sono. OBJETIVO: Descrever o uso da toxina botulínica tipo-A (BoNT-A no manejo do caso de um paciente cujo sono estava gravemente fragmentado por episódios de distonia do membro inferior direito, desencadeados por movimentos periódicos do sono (MPS. MÉTODO: Uma paciente com 79 anos portadora de hemiparesia direita leve seqüelar a isquemia cerebral (AVCI procurou-nos por episódios dolorosos recorrentes de distonia noturna de seu membro inferior direito, os quais fragmentavam seu sono. Os episódios de distonia também podiam ser desencadeados voluntariamente, por extens

  18. Estudio histopatológico e inmunohistoquímico de páncreas en perros diabéticos inducidos con aloxano Histopathologic and immunohistochemical study of pancreas in alloxan-induced diabetic dogs

    OpenAIRE

    V. CUBILLOS; C López; Alberdi, A.

    2008-01-01

    El presente estudio se llevó a cabo en perros diabéticos tipo I inducidos con Aloxano®, con el propósito de evaluar las lesiones microscópicas presentes en páncreas y relacionarlas con la presencia o ausencia de insulina en los islotes de Langerhans a distintos tiempos posinducción. Se utilizaron 20 caninos mestizos, machos enteros de 4 a 7 años de edad, los cuales fueron divididos en 2 grupos: Control (n = 5) y Experimental (n = 15). Este último fue subdividido en grupos de 3 animales cada u...

  19. Tolerancia al daño inducido bajo solicitaciones de contacto cíclicas en carburos cementados WC-Co//Tolerance induced damage under cyclic contact loading of WC-Co cemented carbides

    OpenAIRE

    David Coureaux‐Mustelier; Anna Ingebrand; Alexey Goéz‐Úsuga; Luís Miguel Llanes‐Pitarch

    2014-01-01

    El comportamiento mecánico de los carburos cementados WC-Co ha sido estudiado en detalle teniendo en cuenta los defectos preexistentes del material (daño intrínseco). Sin embargo, la información sobre los efectos del daño inducido en servicio (daño extrínseco) en la integridad estructural de estos materiales esescasa. En este contexto, en este trabajo se evalúa la influencia del daño extrínseco en la resistencia mecánica residual de dos calidades con microestructuras diferentes. Para ello, se...

  20. Estudio prospectivo randomizado doble ciego para valorar la seguridad y eficacia de palonosetrón más aprepitant versus granisetrón en la profilaxis de la emesis inducida por quimioterapia en el transplante de precursores hemotopoyéticos

    OpenAIRE

    Tenorio Núñez, María Concepción

    2013-01-01

    El estudio de las náuseas y vómitos inducidos por quimioterapia (NVIQ) en el acondicionamiento de los trasplantes de precursores hematopoyéticos (TPH) es escaso. Las peculiaridades de este tipo de procedimiento requieren una consideración especial y diferente a la administración de quimioterapia en el contexto del tratamiento de una neoplasia puesto que conlleva un peor control de las NVIQ. El objetivo principal de la tesis consistió en evaluar la eficacia en términos de respuesta completa (R...

  1. Cerebral Palsy (CP) Quiz

    Science.gov (United States)

    ... Submit Button Past Emails CDC Features Pop Quiz: Cerebral Palsy Language: English Español (Spanish) Recommend on Facebook Tweet ... Sandy is the parent of a child with cerebral palsy and the Board President of Gio’s Garden , a ...

  2. Efecto Protector de Peumus Boldus en ratas con toxicidad hepática inducida por Paracetamol

    Directory of Open Access Journals (Sweden)

    Christiam Ochoa

    2008-01-01

    Full Text Available Objetivo: Comprobar el efecto protector hepático del extracto acuoso de boldo (EAB (Peumus boldus al daño hepático inducido por acetaminofén (paracetamol. Diseño: Analítico, experimental, aleatorizado, completo ¿ experimento verdadero. Realizado en el Instituto de Patología de la Facultad de Medicina de UNMSM. Material y método. 30 Ratas Holtzman macho de 250g y dos meses se dividieron en 5 grupos aleatoriamente, grupo blanco, control paracetamol 200mg/kg y 3 experimentales tratados con EAB a 80 mg/kg, 120 mg/kg y 160 mg/kg respectivamente. Se administró EAB de 80 mg/kg, 120 mg/kg y 160 mg/kg vía orogástrica. Luego de media hora se administró paracetamol 200mg/kg i.p. a los grupos control y experimentales. Este procedimiento se repitió por 5 días. Se tomó pruebas de transaminasas (TGP basal y final en sangre. Se utilizó la prueba de Kruskal-Wallis para analizar la data y un p<0.05 fue considerado significante. Se estudió la anatomopatología de los hígados y se tomaron muestras de tejido teñidas con HE. Resultados: Existe diferencia significativa en los niveles de transaminasas (TGP entre grupos (p<0.05. El control obtuvo 196.6 U/L +- 38.1 (TGP mientras que los experimentales como máximo 55.6 U/l. Las muestras control evidencian signos de lesión hepática, degeneración grasa, congestión sinusoidal y centrolobulillar, y necrosis celular. Sin embargo los grupos experimentales no presentan signos de lesión celular y hay ausencia de inflamación. Conclusiones: El boldo tiene un efecto protector hepático al daño inducido por paracetamol en ratas Holtzmann.

  3. EFECTO PROTECTOR DE PEUMUS BOLDUS EN RATAS CON TOXICIDAD HEPÁTICA INDUCIDA POR PARACETAMOL

    Directory of Open Access Journals (Sweden)

    Christiam Ochoa

    2012-02-01

    Full Text Available Objetivo: Comprobar el efecto protector hepático del extracto acuoso de boldo (EAB (Peumus boldus al daño hepático inducido por acetaminofén (paracetamol. Diseño: Analítico, experimental, aleatorizado, completo – experimento verdadero. Realizado en el Instituto de Patología de la Facultad de Medicina de UNMSM. Material y método. 30 Ratas Holtzman macho de 250g y dos meses se dividieron en 5 grupos aleatoriamente, grupo blanco, control paracetamol 200mg/kg y 3 experimentales tratados con EAB a 80 mg/kg, 120 mg/kg y 160 mg/kg respectivamente. Se administró EAB de 80 mg/kg, 120 mg/kg y 160 mg/kg vía orogástrica. Luego de media hora se administró paracetamol 200mg/kg i.p. a los grupos control y experimentales. Este procedimiento se repitió por 5 días. Se tomó pruebas de transaminasas (TGP basal y final en sangre. Se utilizó la prueba de Kruskal-Wallis para analizar la data y un p<0.05 fue considerado significante. Se estudió la anatomopatología de los hígados y se tomaron muestras de tejido teñidas con HE. Resultados: Existe diferencia significativa en los niveles de transaminasas (TGP entre grupos (p<0.05. El control obtuvo 196.6 U/L +- 38.1 (TGP mientras que los experimentales como máximo 55.6 U/l. Las muestras control evidencian signos de lesión hepática, degeneración grasa, congestión sinusoidal y centrolobulillar, y necrosis celular. Sin embargo los grupos experimentales no presentan signos de lesión celular y hay ausencia de inflamación. Conclusiones: El boldo tiene un efecto protector hepático al daño inducido por paracetamol en ratas Holtzmann.

  4. Desempeño reproductivo del bocachico Prochilodus magdalenae inducido dos veces en un mismo año

    Directory of Open Access Journals (Sweden)

    Víctor Atencio G.

    2013-03-01

    Full Text Available Objetivo. Evaluar el desempeño reproductivo del bocachico (Prochilodus magdalenae sometido a dos inducciones hormonales con extracto pituitario de carpa (EPC en un mismo año. Materiales y métodos. 23 hembras, en fase de maduración final, fueron inducidas con 5mg EPC/Kg de peso vivo, en dos aplicaciones, inicialmente 10% y doce horas después 90% restante. A los machos fue aplicado 80% de la dosis total de las hembras. Resultados. Después de la primera inducción hormonal, las hembras estuvieron aptas nuevamente a los 97.6±12.4 días. El índice de ovulación en ambas inducciones fue de 0.91 (21/23. La fecundidad absoluta (g-ovocitos/hembra no presentó diferencias significativa entre la primera y segunda inducción (36.2 y 44.6 g-ovocitos/hembra, respectivamente (p>0.05; pero cuando se expresó en número de ovocitos/hembra se observó diferencia significativa (p<0.05, siendo mayor en la primera inducción (53535 ovocitos/hembra que en la segunda (40658 ovocitos/hembra. La fecundidad relativa, expresada tanto en g-ovocitos/Kg-hembra como ovocitos/Kg-hembra, mostraron diferencia significativa, siendo mayor en la primera inducción (p<0.05. La tasa de fecundación (73.9±19.6% y eclosión (56.9±17.9% fueron mayores en la primera inducción, comparadas con la segunda (55.6±21.1% y 35.6±20.7%, respectivamente (p<0.05. Conclusiones. Después de una inducción hormonal se requiere de aproximadamente tres meses para que una hembra de bocachico alcance nuevamente la maduración final y esté apta para una nueva inducción hormonal. El índice de ovulación no fue afectado por una segunda inducción en un mismo año, pero la fecundidad absoluta y relativa puede disminuirse entre 24 y 66% y las tasas de fecundación y eclosión entre 23 y 36%.

  5. Unilateral cerebral polymicrogyria with ipsilateral cerebral hemiatrophy

    International Nuclear Information System (INIS)

    We evaluated six children in whom MR imaging showed unilateral cerebral polymicrogyria associated with ipsilateral cerebral atrophy and ipsilateral brain stem atrophy. The aim of this study was to clarify whether this disorder based on neuroimaging constitutes a new homogeneous clinical entity. The subjects were six children whose ages at the time of MR imaging ranged from 8 months to 11 years. Their clinical and MR features were analyzed. All of the children were born between 38 and 42 weeks gestation, without any significant perinatal events. Spastic hemiplegia and epilepsy were observed in all of the patients, and mental retardation was observed in four. The MR findings included unilateral cerebral polymicrogyria associated with ipsilateral cerebral hemiatrophy and ipsilateral brain stem atrophy in all patients. The ipsilateral sylvian fissure was hypoplastic in four patients. These patients showed relatively homogeneous clinical and neuroimaging features. Although the additional clinical features varied according to the site and the extent affected by the polymicrogyria, this disorder could constitute a new relatively homogeneous clinical entity. (orig.)

  6. Unilateral cerebral polymicrogyria with ipsilateral cerebral hemiatrophy

    Energy Technology Data Exchange (ETDEWEB)

    Hayakawa, Katsumi [Department of Radiology, Kyoto City Hospital, 1-2 Higashi-Takada-cho, Mibu, Nakagyo-ku, 604-8845 Kyoto (Japan); Kanda, Toyoko; Yamori, Yuriko [Department of Pediatric Neurology, St. Joseph Hospital for Handicapped Children, 603-8323 Kyoto (Japan)

    2002-10-01

    We evaluated six children in whom MR imaging showed unilateral cerebral polymicrogyria associated with ipsilateral cerebral atrophy and ipsilateral brain stem atrophy. The aim of this study was to clarify whether this disorder based on neuroimaging constitutes a new homogeneous clinical entity. The subjects were six children whose ages at the time of MR imaging ranged from 8 months to 11 years. Their clinical and MR features were analyzed. All of the children were born between 38 and 42 weeks gestation, without any significant perinatal events. Spastic hemiplegia and epilepsy were observed in all of the patients, and mental retardation was observed in four. The MR findings included unilateral cerebral polymicrogyria associated with ipsilateral cerebral hemiatrophy and ipsilateral brain stem atrophy in all patients. The ipsilateral sylvian fissure was hypoplastic in four patients. These patients showed relatively homogeneous clinical and neuroimaging features. Although the additional clinical features varied according to the site and the extent affected by the polymicrogyria, this disorder could constitute a new relatively homogeneous clinical entity. (orig.)

  7. Esquistossomose mansônica cerebral

    Directory of Open Access Journals (Sweden)

    Andyr Nazareth Andrade

    1989-03-01

    Full Text Available Relata-se um caso de neuroesquistossomose (NE mansônica cerebral forma granulomatosa pseudotumoral de localização no córtex do lobo parietal esquerdo determinando, hemiparesia direita e síndrome de hipertensão intracraniana, diagnosticado por biópsia cirúrgica. Fatores vasculares e imunológicos são considerados na fisiopatogenia da NE. Enfatiza-se a necessidade de melhor se estudar, diagnosticar e divulgar as várias formas de envolvimento do SN na esquistossomose mansônica, que parece ser mais freqüente do que se julga atualmente. O comprometimento cerebral com repercussão clínica nesta doença é raro, sendo a forma pseudotumoral limitada a poucos casos descritos na literatura.

  8. Cerebral Aneurysms Fact Sheet

    Science.gov (United States)

    ... cerebral aneurysm from forming. People with a diagnosed brain aneurysm should carefully control high blood pressure, stop smoking, and avoid cocaine use or other stimulant drugs. They should also ...

  9. Cerebral amyloid angiopathy

    Science.gov (United States)

    ... Fenichel GM, Jankovic J, Mazziotta JC, eds. Bradley's Neurology in Clinical Practice . 6th ed. Philadelphia, PA: Elsevier ... al. Course of cerebral amyloid angiopathy-related inflammation. Neurology. 2007;68:1411-1416. PMID: 17452586 www.ncbi. ...

  10. Acute ischemic cerebral attack

    OpenAIRE

    Franco-Garcia Samir; Barreiro-Pinto Belis

    2010-01-01

    The decrease of the cerebral blood flow below the threshold of autoregulation led to changes of cerebral ischemia and necrosis that traduce in signs and symtoms of focal neurologic dysfunction called acute cerebrovascular symdrome (ACS) or stroke. Two big groups according to its etiology are included in this category the hemorragic that constitue a 20% and the ischemic a 80% of cases. Great interest has wom the ischemic ACS because of its high social burden, being the third cause of no violen...

  11. Cerebral Palsy Litigation

    OpenAIRE

    Sartwelle, Thomas P.; Johnston, James C.

    2015-01-01

    The cardinal driver of cerebral palsy litigation is electronic fetal monitoring, which has continued unabated for 40 years. Electronic fetal monitoring, however, is based on 19th-century childbirth myths, a virtually nonexistent scientific foundation, and has a false positive rate exceeding 99%. It has not affected the incidence of cerebral palsy. Electronic fetal monitoring has, however, increased the cesarian section rate, with the expected increase in mortality and morbidity risks to mothe...

  12. Rehabilitation in cerebral palsy.

    OpenAIRE

    Molnar, G. E.

    1991-01-01

    Cerebral palsy is the most frequent physical disability of childhood onset. Over the past four decades, prevalence has remained remarkably constant at 2 to 3 per 1,000 live births in industrialized countries. In this article I concentrate on the rehabilitation and outcome of patients with cerebral palsy. The epidemiologic, pathogenetic, and diagnostic aspects are highlighted briefly as they pertain to the planning and implementation of the rehabilitation process.

  13. Cerebral palsy and congenital malformations

    DEFF Research Database (Denmark)

    Garne, Ester; Dolk, Helen; Krägeloh-Mann, Inge;

    2007-01-01

    AIM: To determine the proportion of children with cerebral palsy (CP) who have cerebral and non-cerebral congenital malformations. METHODS: Data from 11 CP registries contributing to the European Cerebral Palsy Database (SCPE), for children born in the period 1976-1996. The malformations were...... classified as recognized syndromes, chromosomal anomalies, cerebral malformations or non-cerebral malformations. Prevalence of malformations was compared to published data on livebirths from a European database of congenital malformations (EUROCAT). RESULTS: Overall 547 out of 4584 children (11.9%) with CP...... were reported to have a congenital malformation. The majority (8.6% of all children) were diagnosed with a cerebral malformation. The most frequent types of cerebral malformations were microcephaly and hydrocephaly. Non-cerebral malformations were present in 97 CP children and in further 14 CP children...

  14. Sotos syndrome (cerebral gigantism): analysis of 8 cases Síndrome de Sotos (gigantismo cerebral): análise de 8 casos

    OpenAIRE

    Débora Gusmão Melo; Angelina Xavier Acosta; Maria Aparecida de Almeida Salles; João Monteiro de Pina-Neto; José Daniel Vieira Castro; Antonio Carlos Santos

    2002-01-01

    Sotos syndrome or cerebral gigantism is characterized by macrocephaly, overgrowth, mental retardation and central nervous system abnormalities. Congenital heart defects may be present. We report 8 patients with this syndrome and relate their clinical features, neuroimaging and echocardiographic findings.A síndrome de Sotos ou gigantismo cerebral é caracterizada por macrocefalia, hipercrescimento, dismorfias faciais típicas, deficiência mental e alterações do sistema nervoso central. Malformaç...

  15. Nanomedicine in cerebral palsy

    Directory of Open Access Journals (Sweden)

    Balakrishnan B

    2013-11-01

    Full Text Available Bindu Balakrishnan,1 Elizabeth Nance,1 Michael V Johnston,2 Rangaramanujam Kannan,3 Sujatha Kannan1 1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University; Baltimore, MD, USA; 2Department of Neurology and Pediatrics, Kennedy Krieger Institute, Baltimore, MD, USA; 3Department of Ophthalmology, Center for Nanomedicine, Johns Hopkins University, Baltimore, MD, USA Abstract: Cerebral palsy is a chronic childhood disorder that can have diverse etiologies. Injury to the developing brain that occurs either in utero or soon after birth can result in the motor, sensory, and cognitive deficits seen in cerebral palsy. Although the etiologies for cerebral palsy are variable, neuroinflammation plays a key role in the pathophysiology of the brain injury irrespective of the etiology. Currently, there is no effective cure for cerebral palsy. Nanomedicine offers a new frontier in the development of therapies for prevention and treatment of brain injury resulting in cerebral palsy. Nanomaterials such as dendrimers provide opportunities for the targeted delivery of multiple drugs that can mitigate several pathways involved in injury and can be delivered specifically to the cells that are responsible for neuroinflammation and injury. These materials also offer the opportunity to deliver agents that would promote repair and regeneration in the brain, resulting not only in attenuation of injury, but also enabling normal growth. In this review, the current advances in nanotechnology for treatment of brain injury are discussed with specific relevance to cerebral palsy. Future directions that would facilitate clinical translation in neonates and children are also addressed. Keywords: dendrimer, cerebral palsy, neuroinflammation, nanoparticle, neonatal brain injury, G4OH-PAMAM

  16. Clinical Neuroimaging of cerebral ischemia

    Energy Technology Data Exchange (ETDEWEB)

    Nakagawara, Jyoji [Nakamura Memorial Hospital, Sapporo (Japan)

    1999-06-01

    Notice points in clinical imaging of cerebral ischemia are reviewed. When cerebral blood flow is determined in acute stage of cerebral embolism (cerebral blood flow SPECT), it is important to find area of ischemic core and ischemic penumbra. When large cortex area is assigned to ischemic penumbra, thrombolytic therapy is positively adapted, but cautious correspondence is necessary when ischemic core is recognized. DWI is superior in the detection of area equivalent to ischemic core of early stage, but, in imaging of area equivalent to ischemic penumbra, perfusion image or distribution image of cerebral blood volume (CBV) by MRI need to be combined. Luxury perfusion detected by cerebral blood flow SPECT in the cases of acute cerebral embolism suggests vascular recanalization, but a comparison with CT/MRI and continuous assessment of cerebral circulation dynamics were necessary in order to predict brain tissue disease (metabolic abnormality). In hemodynamic cerebral ischemia, it is important to find stage 2 equivalent to misery perfusion by quantification of cerebral blood flow SPECT. Degree of diaschisis can indicate seriousness of brain dysfunction for lacuna infarct. Because cerebral circulation reserve ability (perfusion pressure) is normal in all areas of the low cerebral blood flow by diaschisis mechanism, their areas are easily distinguished from those of hemodynamic cerebral ischemia. (K.H.)

  17. Terapia Miofuncional en pacientes con parálisis cerebral

    OpenAIRE

    Gónzalez Amigo, José

    2015-01-01

    En el presente trabajo, se va a llevar a cabo una visión de la parálisis cerebral desde el punto de vista de la motricidad. La parálisis cerebral es una patología que se caracteriza fundamentalmente por una alteración a nivel motriz, que puede afectar a las diferentes extremidades así como a los órganos involucrados en el habla. Estas limitaciones en la región orofacial pueden producir importantes distorsiones y como consecuencia el discurso puede resultar ininteligible para los interlocutore...

  18. La parálisis cerebral en el cine

    OpenAIRE

    Merino Marcos, María Lucila

    2005-01-01

    [ES] En los últimos veinticinco años se han rodado un número importante de películas en las que el protagonista o algún personaje secundario presentaban o simulaban una parálisis cerebral. Estos personajes en ocasiones han sido interpretados por personas con minusvalías. En la narración de su historia las cintas han incluido diversos aspectos sanitario-asistenciales, sociales y familiares obligados en el campo de la parálisis cerebral. [EN] In the last twenty-five years, a number of import...

  19. DEGRADACIÓN DE SUELOS POR ACTIVIDADES ANTRÓPICAS EN EL NORTE DE TAMAULIPAS, MÉXICO

    Directory of Open Access Journals (Sweden)

    M. Espinosa Ramírez

    2011-01-01

    Full Text Available La degradación de los suelos es un proceso que puede estar inducido por el hombre y que disminuye la capacidad actual y/o futura para sostener la vida humana. En este trabajo se estudia la Zona II de la Cuenca de Burgos (México con el objetivo de evaluar y conocer los distintos tipos de degradación, originada por la acción antrópica. Para ello se delimitaron los tipos de suelo, se seleccionaron áreas representativas para realizar perfiles de suelos y se evaluó la degradación de los mismos siguiendo la metodología de ASSOD (Van Lyden, 1997. Los resultados muestran como el 74% del área estudiada presenta evidencias de degradación. Los tipos dominantes son: erosión hídrica, compactación y erosión eólica. Las causas principales son el sobrepastoreo y las prácticas agrícolas superficiales, a lo que hay que añadir las actividades industriales recientes de PEMEX. La degradación más acusada se presenta en Calcisoles. Los Leptosoles, por el contrario, tienen menor degradación, pero es en donde se da la mayor actividad industrial.

  20. Análisis del efecto chimenea en fachadas ventiladas opacas mediante correlaciones del flujo másico inducido. Aplicación para el dimensionado de anchos de cámara

    Directory of Open Access Journals (Sweden)

    Suárez, C.

    2015-06-01

    Full Text Available A general analysis of the stack effect problem applied to opaque ventilated facades is made in this paper. From an energetic point of view, the design and optimization of ventilated facades, require a deep understanding of the thermal and fluid dynamic phenomena that take place in the air gap, and, due to the complexity of these phenomena, the optimal design is a challenge to architects and engineers. As a main result, useful correlations for calculating the induced mass flow into the ventilated cavity are proposed depending on the geometry and the temperature difference. The set of application of the correlation covers the usual range of interest in opaque ventilated facades. It is also made a sensitive analysis of the induced flow with the indicated parameters.En el presente artículo, se realiza un análisis general del problema del efecto chimenea aplicado a las fachadas ventiladas opacas. Desde un punto de vista energético, el diseño y la optimización de las fachadas ventiladas requiere un profundo conocimiento de los fenómenos térmicos y fluidodinámicos que se producen en la cámara ventilada y debido a la complejidad de estos fenómenos, el diseño óptimo supone un reto para arquitectos e ingenieros. Como resultado principal, se proponen unas correlaciones útiles para el cálculo del flujo másico inducido en la cavidad ventilada en función de la geometría y de la diferencia de temperaturas. El conjunto de casos de aplicación de las correlaciones cubre el rango habitual de interés en fachadas ventiladas opacas. Asimismo se realiza un análisis de sensibilidad del caudal inducido al variar los parámetros señalados.

  1. Cerebral abscess in children

    International Nuclear Information System (INIS)

    A cerebral abscess (CA) is a focal, infectious process only or multiple, located in the cerebral parenchyma that produces tisular lysis and it behaves like a lesion of space occupative, being a suppurative illness, who origin is a distant infection, or for continuity that studies initially as an area of focal cerebritis and it is developed to a collection surrounded purulent. At the moment they are perfecting technical and protocols diagnoses and therapeutic and measures for allow to control the natural history of the illness, making from the confrontation to this pathology a necessarily interdisciplinary complicated art, stiller in the infantile population, due to their difficulty in the diagnosis and the relevance of the same one. The paper includes epidemiology, etiology, risk factors, localization, pathology, clinic, diagnoses, treatment and diagnostic images

  2. Cerebral hemodynamics in migraine

    DEFF Research Database (Denmark)

    Hachinski, V C; Olesen, Jes; Norris, J W;

    1977-01-01

    Clinical and angiographic findings in migraine are briefly reviewed in relation to cerebral hemodynamic changes shown by regional cerebral blood flow (rCBF) studies. Three cases of migraine studied by the intracarotid xenon 133 method during attacks are reported. In classic migraine, with typical...... prodromal symptoms, a decrease in cerebral blood flow has been demonstrated during the aura. Occasionally, this flow decrease persists during the headache phase. In common migraine, where such prodromata are not seen, a flow decrease has not been demonstrated. During the headache phase of both types...... of migraine, rCBF has usually been found to be normal or in the high range of normal values. The high values may represent postischemic hyperemia, but are probably more frequently secondary to arousal caused by pain. Thus, during the headache phase rCBF may be subnormal, normal or high. These findings do...

  3. Cerebral fat embolism

    International Nuclear Information System (INIS)

    A case of cerebral fat embolism is reported. A 18-year-old patient with multiple bone fractures was in semiconma immediately after an injury. Brain CT showed no brain swelling or intracranial hematoma. Hypoxemia and alcoholemia were noted on admission, which returned to normal without improvement of consciousness level. In addition, respiratory symptoms with positive radiographic changes, tachycardia, pyrexia, sudden drop in hemoglobin level, and sudden thrombocytopenia developed. These symptoms were compatible with Gurd's criteria of systemic fat embolism. Eight days after injury, multiple low density areas appeared on CT and disappeared within the subsequent two weeks, and subdural effusion with cerebral atrophy developed. These CT findings were not considered due to cerebral trauma. Diagnosis of cerebral fat embolism was made. The subdural effusion was drained. Neurologic and pulmonary recoveries took place slowly and one month following the injury the patient became alert and exhibited fully coordinated limb movement. The CT scans of the present case well corresponded with hitherto reported pathological findings. Petechiae in the white matter must have developed on the day of injury, which could not be detected by CT examination. It is suggested that some petechial regions fused to purpuras and then gradually resolved when they were detected as multiple low density areas on CT. CT in the purpuras phase would have shown these lesions as high density areas. These lesions must have healed with formation of tiny scars and blood pigment which were demonstrated as the disappearance of multiple low density areas by CT examination. Cerebral atrophy and subsequent subdural effusion developed as a result of demyelination. The patient took the typical clinical course of cerebral fat embolism and serial CT scans served for its assessment. (author)

  4. Experimental Focal Cerebral Ischemia

    DEFF Research Database (Denmark)

    Christensen, Thomas

    2007-01-01

    Focal cerebral ischemia due to occlusion of a major cerebral artery is the cause of ischemic stroke which is a major reason of mortality, morbidity and disability in the populations of the developed countries. In the seven studies summarized in the thesis focal ischemia in rats induced by occlusion......-PBN on the periinfarct depolarizations and infarct volume was investigated. In study number six, the activity of the mitochondrial electron transport complexes I, II and IV was evaluated histochemically during reperfusion after MCAO in order to assess the possible role of mitochondrial dysfunction in focal ischemic...

  5. Cerebral atrophic and degenerative changes following various cerebral diseases, (1)

    International Nuclear Information System (INIS)

    Patients having cerebral atrophic and degenerative changes following hypoglycemia, cerebral contusion, or cerebral hypoxia including cerebrovascular disorders were reported. Description was made as to cerebral changes visualized on CT images and clinical courses of a patient who revived 10 minutes after heart stoppage during neurosurgery, a newborn with asphyxia, a patient with hypoglycemia, a patient who suffered from asphyxia by an accident 10 years before, a patient with carbon monoxide poisoning at an acute stage, a patient who had carbon monoxide poisoning 10 years before, a patient with diffuse cerebral ischemic changes, a patient with cerebral edema around metastatic tumor, a patient with respiration brain, a patient with neurological sequelae after cerebral contusion, a patient who had an operation to excise right parietal lobe artery malformation, and a patient who was shooted by a machine gun and had a lead in the brain for 34 years. (Tsunoda, M.)

  6. Un extracto de Punica granatum L. (BLBu sobre la apoptosis inducida por virus influenza A y B

    Directory of Open Access Journals (Sweden)

    Isis Casadelvalle Pérez

    2006-01-01

    Full Text Available La apoptosis ha sido ampliamente reconocida como un mecanismo intrínseco de autodestrucción en las células animales. Este fenómeno puede ser inducido por múltiples factores, entre los que se pueden citar algunos virus, que lo utilizan como vía de diseminación en el hospedero. Para contrarrestar este mecanismo se han usado extractos obtenidos de plantas con propiedades antivirales, los cuales, intuitivamente, pudieran ejercer su efecto sobre la apoptosis inducida por los virus. En el presente trabajo se estudió el efecto de un extracto natural de Punica granatum L. sobre la apoptosis inducida por dos virus: influenza A e influenza B en dos líneas celulares: MDCK y células Vero. Se determinó la citotoxicidad del extracto y se estimó que el valor de CC50 para la línea celular MDCK resulta de (400 ± 59 mg/mL y en las células Vero de (137,3 ± 23 mg/mL. A concentraciones no citotóxicas el extracto no indujo la fragmentación del ADN. El efecto del extracto sobre las células infectadas con los virus influenza A/ Japan/10/99(H3N2, influenza B/Beijing/88 fue evaluado mediante la técnica del MTT y el análisis de la fragmentación del ADN, técnicas usadas para identificar el proceso de muerte apoptótica. El proceso de apoptosis fue inhibido por el extracto a todas las concentraciones y tiempos ensayados. A partir de los resultados, se infiere la existencia de mecanismos comunes de inducción de la apoptosis por estos virus que son interferidos por el extracto natural ensayado.

  7. A importância da musicoterapia na paralisia cerebral:perceção da equipa multiprofissional

    OpenAIRE

    Ribeiro, Emanuela Aurora Nunes

    2013-01-01

    Esta dissertação foca quais os benefícios que uma criança com Paralisia Cerebral pode alcançar ao frequentar a Musicoterapia. Neste sentido, a temática-alvo em análise é a paralisia cerebral, debruçando-se no contributo da área da Música no desenvolvimento cognitivo de uma criança com Paralisia Cerebral segundo vários autores e segundo uma equipa multiprofissional. O indivíduo com paralisia cerebral pode ter os seus movimentos afetados bem como a postura que pode ser causada por uma lesão ...

  8. SEÑALES PRODUCIDAS POR Rhizobium leguminosarum EN LA INTERACCIÓN CON FRIJOL COMÚN (Phaseolus vulgaris L.

    Directory of Open Access Journals (Sweden)

    María C. Nápoles García

    2016-01-01

    Full Text Available La interacción Rhizobium-leguminosas depende de un complejo intercambio de señales, que se mantiene durante todo el proceso simbiótico y de las que solamente una combinación correcta permitirá una simbiosis eficiente. Estas plantas secretan flavonoides, reconocidos por bacterias compatibles y que inducen sus genes nod. Estos codifican las proteínas que sintetizan y exportan lipoquitooligosacáridos conocidos como factores Nod. Los factores Nod activan los procesos de infección e inician la división celular en la raíz, hasta la formación del nódulo y participan también en la fijación biológica del nitrógeno. Existen evidencias de que el uso de inductores de los genes nod incrementa la nodulación en algunas leguminosas. El objetivo de este trabajo fue estudiar la producción de algunas moléculas señales, inducidas por la isoflavona genisteína en una cepa de R. leguminosarum y evaluar el impacto de esa inducción en el efecto del inóculo sobre plantas de frijol común. La fracción lipídica en los inóculos fue extraída con n-butanol y analizada por cromatografía de capa fina, cromatografía líquida de alta resolución y cromatografía gaseosa acoplada a un espectrómetro de masas. En los inóculos inducidos con genisteína se detectó una cantidad superior de lipooligosacáridos (factores de nodulación y de ácidos grasos de alto peso molecular, con diferencias significativas respecto a los controles sin inducir. En relación con ese enriquecimiento en moléculas señales, los inóculos inducidos con genisteína, mostraron un efecto positivo en las plantas de frijol de la variedad Cubacueto 25-9, con mayor número de nódulos y contenido de clorofila que las plantas no inoculadas (control.

  9. O sujeito cerebral e o movimento da neurodiversidade

    Directory of Open Access Journals (Sweden)

    Francisco Ortega

    2008-10-01

    Full Text Available Este artigo analisa o movimento da neurodiversidade organizado basicamente por autistas chamados de alto funcionamento que consideram que o autismo não é uma doença a ser tratada, mas uma diferença humana, a qual deve ser respeitada como outras diferenças. O movimento da "neurodiversidade" deve ser inserido em um marco sociocultural e histórico mais amplo que incorpore o impacto crescente no imaginário cultural dos saberes e das práticas neurocientíficas com o paradigma do sujeito cerebral e a expansão da neurocultura. No contexto do sujeito cerebral, o cérebro responde por tudo o que outrora costumávamos atribuir à pessoa e vem se tornando um critério biossocial de agrupamento fundamental. O artigo mostra como uma ideologia solipsista, reducionista e cientificista - o sujeito cerebral - pode servir de base para a formação de identidade e de redes de sociabilidade e comunidade.This article analyzes the neurodiversity movement, organized mostly by so-called high-functioning autists, who consider that autism is not a disease to be treated, but rather a human difference that should be respected alongside other differences. The "neurodiversity" movement must be set within a wider sociocultural and historical field that incorporates the growing impact of neuroscientific knowledge and practices in the cultural imagination with the paradigm of the cerebral subject and the expansion of neuroculture. In the context of the cerebral subject, the brain accounts for all that we used to attribute to the person, and it is becoming a fundamental criterion for biosocial grouping. The article shows how a solipsist, reductionist and scientificist ideology - the cerebral subject - can act as the basis for the formation of identity and networks of sociability and community.

  10. Recurrent cerebral thrombosis

    International Nuclear Information System (INIS)

    Neuroradiological techniques were used to elucidate pathophysiology of recurrent cerebral thrombosis. Twenty-two patients with cerebral thrombosis who suffered a second attack under stable conditions more than 22 days after the initial stroke were studied. Hypertension, diabetes mellitus, and hypercholesterolemia were also seen in 20, 8, and 12 patients, respectively. The patients were divided into three groups according to their symptoms: (I) symptoms differed between the first and second strokes (n=12); (II) initial symptoms were suddenly deteriorated (n=6); and (III) symptoms occurring in groups I and II were seen (n=4). In group I, contralateral hemiparesis or suprabulbar palsy was often associated with the initial hemiparesis. The time of recurrent stroke varied from 4 months to 9 years. CT and MRI showed not only lacunae in both hemispheres, but also deep white-matter ischemia of the centrum semi-ovale. In group II, hemiparesis or visual field defect was deteriorated early after the initial stroke. In addition, neuroimaging revealed that infarction in the posterior cerebral artery was progressed on the contralateral side, or that white matter lesion in the middle artery was enlarged in spite of small lesion in the left cerebral hemisphere. All patients in group III had deterioration of right hemiparesis associated with aphasia. CT, MRI, SPECT, and angiography indicated deep white-matter ischemia caused by main trunk lesions in the left hemisphere. Group III seemed to be equivalent to group II, except for laterality of the lesion. Neuroradiological assessment of the initial stroke may help to predict the mode of recurrence, although pathophysiology of cerebral thrombosis is complicated and varies from patient to patient. (N.K.)

  11. Activity of the protector chlorophyllin or promoter of the genetic damage induced by the 1,2 dimethyl hydrazine; Actividad de la clorofilina protectora o promotora del dano genetico inducido por la 1,2 dimetil hidrazina

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero M, M.G

    2004-07-01

    The chlorophyllin (CHLN) it is a porphyrin of soluble nutritious grade in water, derived of the chlorophyll that includes in their structure a copper atom. It has been reported that this pigment can act as anti mutagen, reducing the damage to the DNA caused by physical or chemical agents of direct or indirect action. Their anti carcinogen action has also been studied during the initiation phase induced for carcinogen as the aflatoxins and heterocyclic amines. In contrast the reports have increased on a probable promoter activity of the CHLN on the induced genetic damage. This effect was seen for the first time before the damage induced by alkylating agents in Salmonella. Recently it has been observed with the damage induced by gamma radiation, ENU and CrO{sub 3} in somatic cells of the wing of Drosophila and in the induction of tumors for 1,2-dimethylhydrazine (DMH) in mice. Presently study is evaluated the protective effect or promoter of the CHLN before the genetic damage induced by 1,2-dimethylhydrazine, by means of the bioassay mutation and somatic recombination (SMART) in the wing of Drosophila melanogaster. Its were pretreated with CHLN or SAC to transheterocygotes larvas for two locus of the chromosome three mwh+/+flr{sup 3}; later on they are retarded the chronic treatment with DMH 0, 1, 2 and 3 days. It was measured the toxicity and the speed of development of the treated individuals. The wings of those adults that emerged were analyzed to register the number and the size of stains. The results indicated: differences in the viability of the individuals of the groups SAC + DMH vs CHLN + DMH only in the treated immediately after the pretreatment (DRT-0) that the CHLN doesn't modify the rate of the treated individuals development. The results of somatic mutation indicated that the CHLN has a protective effect only immediately after the pretreatment (DRT-0) however in DRT-1, 2 and 3 showed a promoter effect of genetic damage. (Author)

  12. Thermal annealing of high dose radiation induced damage at room temperature in alkaline. Stored energy, thermoluminescence and coloration; Aniquilacion termica de dano inducido por irradiacion a altas dosis en haluros alcalinos a 300 k. energia almacenda. Termoluminiscencia y coloracion

    Energy Technology Data Exchange (ETDEWEB)

    Delgado, L.

    1980-07-01

    The possible relation between stored energy, thermoluminescence and colour centre annealing in gamma and electron irradiated alkali halides is studied. Thermoluminescence occurs at temperature higher than the temperature at which the main stored energy peak appears. No stored energy release is detected in additively coloured KC1 samples. Plastic deformation and doping with Ca and Sr induce a stored energy spectrum different from the spectrum observed in pure and as cleaved samples, but the amount of stored energy does not change for a given irradiation dose.Capacity of alkali halides to store energy by irradiation increases as the cation size decreases. (Author) 51 refs.

  13. Action of the chlorophyllin on the genetic damage induced by gamma radiation in germinal cells of Drosophila Melanogaster; Accion de la clorofilina sobre el dano genetico inducido por radiacion gamma en celulas germinales de Drosophila Melanogaster

    Energy Technology Data Exchange (ETDEWEB)

    Cruces, M.P.; Pimentel, A.E.; Moreno, A.; Moreno, R. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2003-07-01

    The obtained results using somatic cells, they have evidenced that the chlorophyllin (CHLN) it can act inhibiting or increasing the damage caused by different mutagens. The objective of this investigation is to evaluate the effect of the CHLN on the damage induced by gamma radiation in germinal cells of Drosophila. Two tests were used, the lost of the X chromosome and the conventional test of lethal recessive bound to the sex (LRLS); both with a system of litters. The obtained results in both essays, indicated that the CHLN doesn't reduce the damage induced by the gamma radiation in none of the cellular monitored states. (Author)

  14. Modifier activity of the protoporphyrin IX of the clastogenic damage induced by gamma radiation in Drosophila melanogaster; Actividad modificadora de la protoporfirina IX del dano clastogenico inducido por radiacion gamma en Drosophila melanogaster

    Energy Technology Data Exchange (ETDEWEB)

    Martinez A, G. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico)

    2007-07-01

    It has been demonstrated that the copper sodium chlorophyllin (CCS) it is a potent inhibitor of the one genetic damage induced by physical or chemical agents in systems like: bacteria, Drosophila, rainbow trout and mammals. Nevertheless it has been observed that under certain conditions it promotes it. In the laboratory of Drosophila of the ININ evidences have been obtained that the CCS increases the percentage of lethal embryonic dominant and post-embryonic induced by gamma radiation. One of the probable causes of this effect promoter, is the oxidizer stress that it could cause the metallic center of the CCS. The objective of this investigation it was the evaluation of the inhibitory action of the protoporphyrin IX (PP-IX) of the genetic damage induced by gamma radiation in the germinal line of Drosophila melanogaster. For such effect it was used the lethal dominant test by means of two protocols: one in the one that the PP-IX or CCS was administered to the females and the other one to the males. Females of genotype y/y and males of the canton-S stump were used. In both cases the males were treated with 40 Gy of gamma radiation. Its were count the embryonic lethal dominant (L-E) and those post-embryonic (L-PE) of the F1. The results indicated that after the one pretreatment with PP-IX to the crossed females with males treaties increase the percentage of L-E (P {<=} 0.001) and it diminished that of L-PE (P {<=} 0.001) compared with the sucrose control more radiation, however when it was pretreated with CCS also it was observed an increment in the percentage of L-E (P {<=} 0.001), but it doesn't present effect on that of L-PE. In contrast, when the males were pretreated, it was observed that the PP-IX tends to increase those L-E, but diminished the L-PE (P {<=} 0.05), however when it was pretreated with CCS was observed that increased the percentage of L-E (P {<=} 0.001) but diminished that of L-PE (P {<=} 0.001). It was concluded that none of the two pigments act as inhibitor of the damage; for the contrary one promoted it, and that the metallic center can possibly be the one responsible of the promoter effect observed. (Author)

  15. Influence of some exo nucleases in response to the induced genetic damage in Escherichia coli by alpha radiation; Influencia de algunas exonucleasas en respuesta al dano genetico inducido en Escherichia coli por radiacion alfa

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar M, M

    2005-07-01

    Within the strategies with those that E. coli counts to overcome to the genetic damage there is the SOS response, a group of genes that participate in repair and/or tolerance that it confers to the bacteria major opportunities of surviving. These genes are repressed and its only are expressed when it happens genetic damage. So that this system is activated it is necessary that DNA of a band exists and in this sense the double ruptures (RDB) its are not able to induce this response unless there is a previous processing. In stumps with defects in certain genes that have to do with repair of RDB (as recO, recJ and xonA) the activity of SOS is smaller than in a wild stump what suggests that these participate in the previous processes to the activation of the response. The ionizing radiation produce among other many lesions, RDB in greater or smaller proportion, depending on the ionization capacity. A parameter to evaluate this capacity is the lineal energy transfer (LET), defined as the average energy given by unit of distance travelled. In general the LET of the corpuscular radiations is a lot but high that of the electromagnetic one, for what produces bigger quantity of ionizations inside a restricted zone and it increases by this way the probability that RDB has been generated. This work has for object to infer the participation of xonA and recJ in this response and to evaluate the damage produced by ionizing radiation of different LET (alpha particles of different energies) in a stump with all the functional repair mechanisms. Its were considered two parameters: the survival and the activity of SOS evaluated by means of the chromo test. The results indicate that the activity of these exo nucleases is necessary for the repair of RDB as well as for the processing of lesions foresaw to the activation of SOS. As for the treatment with alphas of different energies is observed that so much the survival like the activity of SOS vary as the LET of the radiation changes used due surely to the proportion of RDB that produces each one of them. It is observed that the treatments that have a smaller survival also present a smaller activation of this response. (Author)

  16. Magnitud del enfisema inducido por elastasa: Posible relación con el tipo de daño agudo pulmonar Elastase induced emphysema: Possible relationship with the type of acute lung injury

    OpenAIRE

    ANDREA VECCHIOLA C; PILAR CELIS L; PABLO SANDOVAL R; ALFONSO LEÓN F; ANDREA VILLAGRÁN T; ALEJANDRO RAMÍREZ M; GISELLA BORZONE T

    2009-01-01

    Introducción: El modelo de instilación intratraqueal de elastasa induce daño alveolar difuso y destrucción de la matriz extracelular con desarrollo de enfisema. Sin embargo, el hámster Syrian Golden desarrolla enfisema más severo que el de la rata Sprague-Dawley. Si bien se sabe que los eventos tempranos después de la instilación de elastasa determinan la magnitud del enfisema, se desconoce si existen diferencias entre especies en la respuesta pulmonar temprana. Objetivo: Evaluar si existen d...

  17. Simulation by the effect of the Sloshing induced by an earthquake in fuel pools of Cofrentes NPP; Simulacion mediante CFD del efecto del Sloshing inducido por un sismo en las piscinas de combustible C. N. Cofrentes

    Energy Technology Data Exchange (ETDEWEB)

    Sarti Fernandez, F.; Gavilan Moreno, C.; Paez Ortega, E.

    2012-07-01

    After analyzing the results of this study, it was concluded that the use of CFD tools brings a level of knowledge and detail of phenomena and superior to traditional methods derived effects. This, coupled with the reduction of time and costs of Dynamics Simulations, technological advances have been providing in recent years, its application makes it very interesting.

  18. Estimate of the damage in organs induced by neutrons in three-dimensional conformal radiotherapy; Estimacion del dano en organos inducido por neutrones en radioterapia conformada en 3D

    Energy Technology Data Exchange (ETDEWEB)

    Benites R, J. L. [Centro Estatal de Cancerologia de Nayarit, Servicio de Seguridad Radiologica, Calzada de la Cruz 118 sur, 63000 Tepic, Nayarit (Mexico); Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico); Uribe, M. del R., E-mail: jlbenitesr@prodigy.net.mx [Instituto Tecnico Superior de Radiologia, Calle Leon No. 129, 63000 Tepic, Nayarit (Mexico)

    2014-08-15

    By means of Monte Carlo methods was considered the damage in the organs, induced by neutrons, of patients with cancer that receive treatment in modality of three-dimensional conformal radiotherapy (3D-CRT) with lineal accelerator Varian Ix. The objective of this work was to estimate the damage probability in radiotherapy patients, starting from the effective dose by neutrons in the organs and tissues out of the treatment region. For that a three-dimensional mannequin of equivalent tissue of 30 x 100 x 30 cm{sup 3} was modeled and spherical cells were distributed to estimate the Kerma in equivalent tissue and the absorbed dose by neutrons. With the absorbed dose the effective dose was calculated using the weighting factors for the organ type and radiation type. With the effective dose and the damage factors, considered in the ICRP 103, was considered the probability of damage induction in organs. (Author)

  19. Process of defect formation in alkaline halogenides contaminated with Eu{sup 2+} induced by non ionizing radiation; Procesos de formacion de defectos en halogenuros alcalinos contaminados con Eu{sup 2+} inducidos por radiacion no ionizante

    Energy Technology Data Exchange (ETDEWEB)

    Pedroza M, M.; Melendrez, R.; Barboza F, M. [Centro de Investigacion en Fisica de la Universidad de Sonora, A.P. 5-088, 83190 Hermosillo, Sonora (Mexico); Castaneda, B. [UNISON, A.P. 1626, 83190 Hermosillo, Sonora (Mexico)

    2004-07-01

    The creation of defects in polluted alkaline halogenides with divalent impurities exposed to ionizing radiation is explained by means of the creation of auto trapped excitons (STE), which can be formed by means of the excitement of the halogen ion or through the trapping of electrons in centers V{sub K} taken place during the process of ionization of the halogen ion. The luminescent recombination of the exciton auto trapped produces a characteristic exciton luminescence and the recombination non radiative causes the formation of the Frenkel type defects, even of centers F - H. Experimentally has been demonstrated that the same type of glasses, exposed to radiation non ionizing of the type UV of around 230 nm, they produce defects similar Frenkel. The situation is interesting all time that photons of 230 nm (5.3 eV) they cannot create excitons directly since they are in an energy level of approximately 2.4 inferior eV to the necessary energy for the production of the same ones. In order to investigating the type of process of creation of defects with UV light energy below the energy of the band prohibited in polluted alkaline halogenides with Eu{sup 2+}, mainly looking for experimental information that allows to explain the creation of defects taken place by the radiation non ionizing, one carries out the present work. It was found that, independently of the energy of the radiation used for the excitement, the emission comes from the transition 4f{sup 6}5d(t{sub 2g})-4f{sup 7}({sup 8}S{sub 7/2}) of the ion Eu{sup 2+} characterized by a wide band centered in 420 nm and an additional component in 460 nm of possibly intrinsic origin. It was determined that so much the F centers and F{sub z} participate in the thermoluminescent processes and of optically stimulated luminescence, achieving to identify those peaks of Tl strictly associated to the F centers (peak in 470 K for the KCl: Eu{sup 2+}) and F{sub z} (peak in 370 K). Also, by means of a process of selective photo stimulation evidence was obtained that the F center (peak in 470 K) is directly involved in the process of optically stimulated luminescence. Finally, the results point out that the existence of an exciton type process is more feasible of being observed in materials where the quantum efficiency of the auto trapped exciton emission is significantly bigger to that of the materials studied. (Author)

  20. Magnitud del enfisema inducido por elastasa: Posible relación con el tipo de daño agudo pulmonar Elastase induced emphysema: Possible relationship with the type of acute lung injury

    Directory of Open Access Journals (Sweden)

    ANDREA VECCHIOLA C

    2009-01-01

    Full Text Available Introducción: El modelo de instilación intratraqueal de elastasa induce daño alveolar difuso y destrucción de la matriz extracelular con desarrollo de enfisema. Sin embargo, el hámster Syrian Golden desarrolla enfisema más severo que el de la rata Sprague-Dawley. Si bien se sabe que los eventos tempranos después de la instilación de elastasa determinan la magnitud del enfisema, se desconoce si existen diferencias entre especies en la respuesta pulmonar temprana. Objetivo: Evaluar si existen diferencias entre ratas y hamsters en la respuesta pulmonar inicial después de la elastasa, mediante el uso de marcadores bioquímicos de daño pulmonar agudo. Resultados: Mientras la rata experimenta un gran aumento de permeabilidad alvéolo-capilar y pocos fenómenos hemorrágicos, el hamster presenta abundante hemorragia y escaso aumento de la permeabilidad. Conclusiones: Existen diferencias entre ratas y hamsters en la respuesta pulmonar inicial frente a la elastasa, que podrían tener relación con las diferencias en magnitud del enfisema.Introduction: Intratracheal instillation of elastase induces diffuse alveolar damage and emphysema development. However, the Syrian Golden hamster develops more severe emphysema than the Sprague-Dawley rat. Although it is known that early events after elastase instillation determine the magnitude of emphysema development, it is not known if there are species differences in the initial pattern of lung response to elastase. Objective: To evaluate whether rats and hamster differ in the early lung response to elastase, using biochemical markers of acute lung injury. Results: Whereas the rat shows a large increase in alveolar-capillary permeability and few hemorrhagic changes, the hamster shows significant amount of hemorrhage and a small increase in alveolar capillary permeability. Conclusions: There are differences between rats and hamsters in the initial lung response to elastase that could influence the magnitude of emphysema development.

  1. Action of the chlorophyllin (CHLN) on the double breaking induced by gamma radiation in germinal cells of Drosophila melanogaster; Accion de la clorofilina (CHLN) sobre los dobles rompimientos inducidos por radiacion gamma en celulas germinales de Drosophila melanogaster

    Energy Technology Data Exchange (ETDEWEB)

    Moreno M, A

    2005-07-01

    The chlorophyllin (CHLN) is a derived of the chlorophyll in the one which the atom of Mg is replaced by Cu. It has been broadly used as preservative in those foods, and in the treatment of geriatric patients. The results using different test systems have demonstrated that the CHLN reduces the DNA damage caused by different physical agents or chemical of direct action or insinuation. Another of the properties of the CHLN is it anti carcinogenic action, because it has been that inhibits the carcinogen activity of B1 (AFB1) aflatoxin and it diminishes the incidence of tumors caused for 2-amine-3-methylimidazo [4- 5f] quinoline (IQ) and it inhibits the development of colon cancer during the post-initiation phase. Recently the reports of the activity promoter of the CHLN have been increased on the genetic damage. This effect observed in Salmonella and later on in Drosophila melanogaster using, physical and chemical agents. Presently study determines the action of the CHLN before the genetic effect induced in germinal cells of Drosophila melanogaster by means of the test of the lost one of the X chromosome in ring using two protocols; the first one consisted on pretreatment with CHLN to the male ones and later on to irradiate them and in the second protocol the pretreatment with CHLN administers to the females, in both protocols its were used a litter systems. (Author)

  2. Daño renal en ratas inducido por veneno de Bothrops neuwiedii diporus de Argentina Renal injury in rats poisoned by venom of Bothrops neuwiedii diporus from Argentina

    Directory of Open Access Journals (Sweden)

    Patricia Koscinczuk

    2004-08-01

    Full Text Available La insuficiencia renal aguda es una de las complicaciones sistémicas más frecuentes después de un accidente ofídico. En este estudio se evalúan los efectos que el veneno de Bothrops neuwiedii diporus produce en el riñón de ratas machos de la cepa Wistar. La histopatología permitió comprobar el desarrollo de necrosis tubular aguda; las lesiones iniciales se observaron a las 3 horas de la inoculación de una dosis de 700 µg del veneno, observándose en corteza renal congestión y degeneración granulohialina de las células epiteliales tubulares, acompañadas de dilatación y cilindros hialinos en la luz tubular. A las 24 horas se presentó necrosis tubular aguda en una superficie extensa de la corteza sin daño de la membrana basal tubular. Las lesiones de degeneración turbia de células epiteliales tubulares, dilatación de la luz tubular y cilindros hialinos se mantuvieron presentes hasta las 4 semanas post-inoculación. Si bien los parámetros de la bioquímica clínica asociados con insuficiencia renal aguda aumentaron a las 6 horas de la administración del veneno (urea: 1.10±0.22 g/dl; creatinina: 19.60±1.51mg/dl, a la semana descendieron a valores normales. Las densidades urinarias, en cambio, a la semana se mantuvieron más bajas que lo normal, 1.005 ± 0.001 (pAcute renal failure is one of the systemic complications that can be found in bothropic accidents. In this study the effects on male Wistar rats induced by the venom of Bothrops neuwiedii diporus were evaluated. The histopathology revealed acute tubular necrosis, lesions firstly were observed 3 hours post inoculation of 700 µg of venom. Cortical kidney congestion and granulohialin degeneration of tubular epithelial cells were observed, these lesions achieved a maximum at 24 hours after inoculation. Tubular epithelial hidropic degeneration and dilatation of tubular lumen with hyalin casts were present inclusive up to 4 weeks after inoculation. Biochemical parameter values associated with kidney renal failure were increased 6 hours after venom inoculation (urea: 1.10± 0.22 g/dl; creatinine: 19.60±1.51 mg/dl, but at the end of the first week they decreased till normal values. The urinary density was lower than normal value: 1.005±0.001 (p<0.001 and at the end of the first month they oscillated between 1.005 and 1.060 (p<0.001. Renal injury induced by B. neuwiedii diporus could be better appreciated by histopathology than by the routine laboratory assays.

  3. Action of the chlorophyllin before genetic damage induced by gamma radiation in germinal cells of Drosophila; Accion de la clorofilina ante el dano genetico inducido por radiacion gamma en celulas germinales de Drosophila

    Energy Technology Data Exchange (ETDEWEB)

    Moreno B, R

    2004-07-01

    The chlorophyllin (CHLN) is a porphyrin of nutritious grade and soluble in water, derived of the chlorophyll. It has been reported that this pigment is a good anti mutagen since it reduces the damage to the DNA caused by physical or chemical agents of direct or indirect action. Their anti carcinogenic action has also been demonstrated when it is administered itself during the induced post-initiation phase by aflatoxins and heterocyclic amines. However in the last decade it has been reported that it also has promoter activity against the genetic damage induced by diverse agents like the alkyl ants of direct and indirect action, the gamma radiation and some heterocyclic amines. This effect has been observed in testing systems like Salmonella, Drosophila, rainbow trout and rodents. In the mouse spermatogonia it has been reported that it reduces the damage to the DNA but with the test of lethal dominant in Drosophila increment the damage induced by gamma radiation. The present study consisted on evaluating the effect of the CHLN in the line germinal masculine of Drosophila by means of the lethal recessive test bound to the sex (LRLS) with the stump Muller 5 and a litters system. Its were pretreated wild males with CHLN and 24 h later were irradiated with 0, 10, 20 and 40 Gy of gamma radiation immediately later were crossed with virgin females of the stump Basc and at 72 h the male was transferred to a cultivation media with three new virgin females, this process repeated three times until completing 3 litters. The F1 it was crossed among itself and in the F2 it was analysed the presence or absence of lethals. The results indicated that the CHLN per se incremented the basal frequency of damage due to the pigment can act as an agent that is inserted to the ADN causing pre mutagenic leisure. Nevertheless with the groups treated with the different doses of gamma radiation the CHLN does not present any protector action, neither promoter except in the litter I of the group treated with 20 Gy where it was observed a promoter effect of genetic damage. (Author)

  4. Twenty-five years of study of the atmospheric contamination by means of proton-induced X-ray emission analysis; Veinticinco anos de estudio de la contaminacion atmosferica mediante microanalisis de rayos X inducidos por particula (PIXE)

    Energy Technology Data Exchange (ETDEWEB)

    Aldape U, F.; Flores M, J., E-mail: francisca.aldape@inin.gob.m [ININ, Departamento de Estudios del Ambiente, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2010-07-01

    At the present time, the microanalysis technique PIXE is accepted by the scientific community as one of the basic techniques used in the study of airborne particle matter, due to the multiple qualities that this offers for the study of this type of pollutants. The nuclear techniques have important applications in the study and technology of solid materials, archaeology and biomedical studies, and particularly in the study of the particles suspended in the air where the PIXE technique is more used because provides reliable results for the identification and quantification of chemical elements from the aluminum until the uranium, including all the metallic elements. Among the main reasons that have motivated the study of the particles suspended in the air is the fact that these cause effects in the human health. At the moment, the sanitary problems associated to the particles are a reason of great concern in many countries where in very populated cities the total of particles in suspension often surpasses the limits settled down by the World Organization of the Health. (Author)

  5. Celulitis por citomegalovirus

    Directory of Open Access Journals (Sweden)

    A. Ruiz Lascano

    2002-12-01

    Full Text Available Las lesiones cutáneas por citomegalovirus (CMV son infrecuentes y a menudo una manifestación tardía de una enfermedad sistémica, que generalmente anuncia un curso fatal. Comunicamos un caso de celulitis por CMV: una mujer de 70 años con trasplante renal efectuado 1 mes antes de la consulta, terapia inmunosupresora con ciclosporina A y metilprednisona. La paciente ingresó por fiebre, dolor e impotencia funcional en pierna derecha. Comprobamos la existencia de una placa de 8 por 4 cm eritematoedematosa. La tratamos con antibióticos sin mejoría, por lo que realizamos un estudio histopatológico de piel que mostró cambios citopáticos compatibles con infección por CMV. Los cultivos bacteriológicos y micológicos fueron negativos. La inmunohistoquímica específica para CMV y el estudio de reacción en cadena de la polimerasa (PCR de la biopsia de piel fueron positivas, al igual que la antigenemia. El tratamiento con ganciclovir produjo la mejoría del cuadro clínico. En la literatura revisada no hemos encontrado la celulitis como manifestación de enfermedad cutánea por CMV.

  6. Papiledema unilateral na síndrome do pseudotumor cerebral

    OpenAIRE

    Mário L. R. Monteiro; Hoyt, William F.; Richard K. Imes; Michael Narahara

    1985-01-01

    São apresentadas as fotografias de fundo de olho de 6 mulheres com papiledema unilateral e a síndrome do pseudotumor cerebral. Achados associados foram: obesidade em 5 e a sindrome da sela vazia parcial em 2. São discutidas as possíveis explicações para o desenvolvimento de papiledema unilateral nesses pacientes e que favorecem um mecanismo presente na porção distal dos nervos ópticos.

  7. Fatores associados ao aborto induzido entre jovens pobres na cidade de São Paulo, 2007 Factores asociados al aborto inducido entre jóvenes pobres en la ciudad de Sao Paulo, 2007 Factors associated with induced abortion among poor youth in the city of São Paulo, 2007

    Directory of Open Access Journals (Sweden)

    Rebeca de Souza e Silva

    2012-12-01

    Full Text Available Esse artigo investiga fatores associados ao aborto induzido entre jovens residentes numa comunidade pobre da cidade de São Paulo. A amostra foi composta por 102 homens e 99 mulheres de 14 a 25 anos de idade que já haviam iniciado suas vidas sexuais. Usou-se o modelo hierárquico de regressão logística. As variáveis não ter companheiro sexual no momento da entrevista, sexo do entrevistado, idade no momento da entrevista, priorizar morar só e número de gestações compuseram o modelo final. Dar muita importância a morar só quadruplica a chance de ocorrer um aborto. Jovens mais velhos foram menos propensos a se deparar com um aborto, dado que a chance de se optar pelo aborto se reduz 17% para cada incremento de um ano na idade dos jovens. Isso é indicativo de que as gestações ocorreram de forma inesperada, intempestiva, como é praxe nas condutas adolescentes, sendo as maiores candidatas a terminarem em aborto provocado. Evidencia-se, portanto, a necessidade de serem investidos recursos financeiros para obtenção de métodos contraceptivos eficazes e inócuos, destinados ao início da vida sexual.Este artículo investiga factores asociados al aborto inducido entre jóvenes residentes en una comunidad pobre de la ciudad de Sao Paulo. La muestra estaba compuesta por 102 hombres y 99 mujeres de 14 a 25 años de edad que ya habían dado inicio a sus vidas sexuales. Se usó el modelo jerárquico de regresión logística. Las variables: no tener compañero sexual en el momento de la entrevista, sexo del entrevistado, edad en el momento de la entrevista, priorizar vivir solo, y número de gestaciones, compusieron el modelo final. Dar mucha importancia a vivir solo cuadruplica la posibilidad de que se produzca un aborto. Jóvenes de mayor edad fueron menos propensos a encontrarse con un aborto, dado que la posibilidad de optar por un aborto se reduce un 17%, respectoa cada incremento de un año en la edad de los jóvenes. Eso es indicativo de

  8. Estudio de los cambios regionales en el flujo sanguíneo cerebral mediante tomografía por emisión de fotoón simple y su correlación neuropsicológica en el trastorno bipolar.

    OpenAIRE

    Benabarre Hernández, Antonio

    2002-01-01

    [spa] Fundamentos: Para algunos trastornos psiquiátricos se ha podido establecer que existe relación entre las disfunciones cognitivas y las alteraciones en el FSCr. Para el trastorno bipolar (TB), distintos trabajos previos han sugerido que los pacientes con este trastorno presentan disfunciones cognitivas. Asimismo, en distintos estudios han sido halladas alteraciones en la distribución del flujo sanguíneo cerebral regional (FSCr) de estos pacientes. No obstante, no existe ningún trabajo pu...

  9. Utilidad de la biopsia estereotáctica en lesiones del tallo cerebral

    OpenAIRE

    HERNÁNDEZ SALAZAR,MANUEL; LORENZANA GALICIA,RODRIGO DANIEL; RAMÍREZ CASTAÑEDA,VICENTE; ZÁRATE MÉNDEZ,ANTONIO; CERVERA MALTOS,ULISES; CEVALLOS MEDINA,JAVIER

    2004-01-01

    La biopsia estereotáctica para lesiones del tallo cerebral (LTC), es de reciente desarrollo a partir de los 80s y es sin duda uno de los campos más revolucionados y prometedores de la medicina, a pesar de su potencial complicación, sin embargo la mayoría de los estudios han mostrado su confiabilidad y certeza. Material y métodos: de 85 biopsias estereotácticas consecutivas, se realizaron 11 biopsias de LTC por estereotaxia (13%). Los diagnósticos se obtuvieron por RM cerebral y TC preoperator...

  10. Evaluación neurofuncional del tallo cerebral Parte II: Reflejo mandibular = Neurofunctional evaluation of brain stem. II. Mandibular reflex

    OpenAIRE

    Leon Sarmiento, Fidias E.; Pabón Porras, María Angélica; Granadillo Deluqu, Elías David

    2011-01-01

    El reflejo mandibular o maseterino posee conexiones nerviosas únicas, diferentes de las exhi­bidas por otros reflejos monosinápticos humanos, y permite evaluar, de forma fácil y eficien­te, el tallo cerebral por medio de la estimulación mecánica, eléctrica o magnética. Diversos estudios han demostrado la participación en este reflejo de las interneuronas del tallo cerebral y su modulación por estructuras supraespinales, que hacen parte fundamental de su integra­ción motora. El reflejo mandibu...

  11. Cerebral localization in antiquity.

    Science.gov (United States)

    Rose, F Clifford

    2009-07-01

    Fragments of neurology can be found in the oldest medical writings in antiquity. Recognizable cerebral localization is seen in Egyptian medical papyri. Most notably, the Edwin Smith papyrus describes hemiplegia after a head injury. Similar echoes can be seen in Homer, the Bible, and the pre-Hippocratic writer Alcmaeon of Croton. While Biblical writers thought that the heart was the seat of the soul, Hippocratic writers located it in the head. Alexandrian anatomists described the nerves, and Galen developed the ventricular theory of cognition whereby mental functions are classified and localized in one of the cerebral ventricles. Medieval scholars, including the early Church Fathers, modified Galenic ventricular theory so as to make it a dynamic model of cognition. Physicians in antiquity subdivided the brain into separate areas and attributed to them different functions, a phenomenon that connects them with modern neurologists. PMID:20183203

  12. Music and cerebral hemodynamics.

    Science.gov (United States)

    Marinoni, M; Grassi, E; Latorraca, S; Caruso, A; Sorbi, S

    2000-09-01

    Previous studies performed by positron emission tomography and Transcranial Doppler (TCD) found a different cerebral activation during musical stimuli in musicians compared to non-musicians. The aim of our study is to evaluate by means of TCD, possible different pattern of cerebral activation during the performance of different musical tasks in musicians, non-musicians and lyrical singers. Our findings show a left hemispheric activation in musicians and a right one in non-musicians. Preliminary data on lyrical singers' activation patterns need further confirmation with a larger population. These data could be related to a different approach to music listening in musicians (analytical) and non-musicians who are supposed to have an emotional approach to music. PMID:10942664

  13. Dysphagia in cerebral palsy

    OpenAIRE

    Salghetti, Annamaria; Martinuzzi, Andrea

    2013-01-01

    Abstract. Feeding problemsare often present in children with neuromotor impairment: dysphagia is usuallyseen in the most severe form of cerebral palsy and it’s defined as thedifficulty with any of the four phases of swallowing. Clinical consequences aremalnutrition and recurrent chest infections that reduce expected duration andquality of life. In order to prevent these consequences it’s important todetect with clinical and instrumental examinations dysphagia symptoms and totreat them. Clinic...

  14. Nanomedicine in cerebral palsy

    OpenAIRE

    Balakrishnan B; Nance E; Johnston MV; Kannan R; Kannan S

    2013-01-01

    Bindu Balakrishnan,1 Elizabeth Nance,1 Michael V Johnston,2 Rangaramanujam Kannan,3 Sujatha Kannan1 1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University; Baltimore, MD, USA; 2Department of Neurology and Pediatrics, Kennedy Krieger Institute, Baltimore, MD, USA; 3Department of Ophthalmology, Center for Nanomedicine, Johns Hopkins University, Baltimore, MD, USA Abstract: Cerebral palsy is a chronic childhood disorder that can have diverse etiologies. Injury to the...

  15. Phenylpropanolamine and cerebral hemorrhage

    Energy Technology Data Exchange (ETDEWEB)

    McDowell, J.R.; LeBlanc, H.J.

    1985-05-01

    Computerized tomography, carotid angiograms, and arteriography were used to diagnose several cases of cerebral hemorrhage following the use of phenylpropanolamine. The angiographic picture in one of the three cases was similar to that previously described in association with amphetamine abuse and pseudoephedrine overdose, both substances being chemically and pharmacologically similar to phenylpropanolamine. The study suggests that the arterial change responsible for symptoms may be due to spasm rather than arteriopathy. 14 references, 5 figures.

  16. Radiopharmaceuticals for cerebral studies

    International Nuclear Information System (INIS)

    For obtain good brain scintillation images in nuclear medicine must be used several radiopharmaceuticals. Cerebral studies give a tumors visual image as well as brain anomalities detection and are helpful in the diagnostic diseases . Are described in this work: a cerebrum radiopharmaceuticals classification,labelled compounds proceeding and Tc 99m good properties in for your fast caption, post administration and blood purification for renal way

  17. Phenylpropanolamine and cerebral hemorrhage

    International Nuclear Information System (INIS)

    Computerized tomography, carotid angiograms, and arteriography were used to diagnose several cases of cerebral hemorrhage following the use of phenylpropanolamine. The angiographic picture in one of the three cases was similar to that previously described in association with amphetamine abuse and pseudoephedrine overdose, both substances being chemically and pharmacologically similar to phenylpropanolamine. The study suggests that the arterial change responsible for symptoms may be due to spasm rather than arteriopathy. 14 references, 5 figures

  18. [Insomnia and cerebral hypoperfusion].

    Science.gov (United States)

    Káposzta, Zoltán; Rácz, Klára

    2007-11-18

    Insomnia is defined as difficulty with the initiation, maintenance, duration, or quality of sleep that results in the impairment of daytime functioning, despite adequate opportunity and circumstances for sleep. In most countries approximately every third inhabitant has insomnia. Insomnia can be classified as primary and secondary. The pathogenesis of primary insomnia is unknown, but available evidence suggests a state of hyperarousal. Insomnia secondary to other causes is more common than primary insomnia. Cerebral hypoperfusion can be the cause of insomnia in some cases. In such patients the cerebral blood flow should be improved using parenteral vascular therapy. If insomnia persists despite treatment, then therapy for primary insomnia should be instituted using benzodiazepine-receptor agonists such as Zolpidem, Zopiclone, or Zaleplon. In those cases Midazolam cannot be used for the treatment of insomnia due to its marked negative effect on cerebral blood flow. In Hungary there is a need to organize multidisciplinary Insomnia Clinics because insomnia is more than a disease, it is a public health problem in this century. PMID:17988972

  19. Cerebral oxygenation and hyperthermia

    Directory of Open Access Journals (Sweden)

    Anthony Richard Bain

    2014-03-01

    Full Text Available Hyperthermia is associated with marked reductions in cerebral blood flow (CBF. Increased distribution of cardiac output to the periphery, increases in alveolar ventilation and resultant hypocapnia each contribute to the fall in CBF during passive hyperthermia; however, their relative contribution remains a point of contention, and probably depends on the experimental condition (e.g. posture and degree of hyperthermia. The hyperthermia-induced hyperventilatory response reduces arterial CO2 pressure (PaCO2 causing cerebral vasoconstriction and subsequent reductions in flow. During supine passive hyperthermia, the majority of recent data indicate that reductions in PaCO2 may be the primary, if not sole, culprit for reduced CBF. On the other hand, during more dynamic conditions (e.g. hemorrhage or orthostatic challenges, an inability to appropriately decrease peripheral vascular conductance presents a condition whereby adequate cerebral perfusion pressure may be compromised secondary to reductions in systemic blood pressure. Although studies have reported maintenance of pre-frontal cortex oxygenation (assessed by near-infrared spectroscopy during exercise and severe heat stress, the influence of cutaneous blood flow is known to contaminate this measure. This review discusses the governing mechanisms associated with changes in CBF and oxygenation during moderate to severe (i.e. 1.0°C to 2.0°C increase in body core temperature levels of hyperthermia. Future research directions are provided.

  20. Cerebral malformations without antenatal diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Girard, Nadine J. [Diagnostic Neuroradiology, Hopital Timone, Marseille (France)

    2010-06-15

    Cerebral malformations are usually described following the different steps in development. Disorders of neurulation (dysraphisms), or diverticulation (holoprosencephalies and posterior fossa cysts), and total commissural agenesis are usually diagnosed in utero. In contrast, disorders of histogenesis (proliferation-differentiation, migration, organization) are usually discovered in infants and children. The principal clinical symptoms that may be a clue to cerebral malformation include congenital hemiparesis, epilepsy and mental or psychomotor retardation. MRI is the imaging method of choice to assess cerebral malformations. (orig.)

  1. Cerebral Autoregulation in Normal Pregnancy and Preeclampsia

    NARCIS (Netherlands)

    van Veen, Teelkien R.; Panerai, Ronney B.; Haeri, Sina; Griffioen, Annemiek C.; Zeeman, Gerda; Belfort, Michael A.

    2013-01-01

    OBJECTIVE: To test the hypothesis that preeclampsia is associated with impaired dynamic cerebral autoregulation. METHODS: In a prospective cohort analysis, cerebral blood flow velocity of the middle cerebral artery (determined by transcranial Doppler), blood pressure (determined by noninvasive arter

  2. Neutrophil predominance in induced sputum from asthmatic patients: Therapeutic implications and role of clara cell 16-KD protein Predominio de neutrófilos en esputo inducido de asmáticos: Implicancias terapéuticas y rol de la proteína 16-kD de la célula clara

    Directory of Open Access Journals (Sweden)

    Elisa M. Uribe Echevarría

    2011-08-01

    ísticas clínico-funcionales, el patrón celular y las moléculas solubles del esputo inducido, para guiar el tratamiento apropiado anti-inflamatorio. Se incluyeron 41 pacientes: 21 a 40 años de edad, con asma estable leve a grave, no tratados con esteroides tópicos ni sistémicos y no fumadores. Se obtuvo una muestra de esputo inducido en condiciones basales, una segunda muestra después del tratamiento al azar con budesonida (400 µg dos veces al día o el montelukast (10 mg/d durante seis semanas, y una final después de un período de lavado de 4 semanas. En el frotis por citocentrifugado se evaluó el predominio de eosinófilos (EP o neutrófilos (NP, y en el sobrenadante se determinó LTE4, y CC16. Se midió la variabilidad del flujo espiratorio máximo (PEFV. Un total de 23/41 pacientes correspondieron al EP y 18/41 pacientes con NP. El PEFV fue mayor en el EP que en NP. LTE4 fue mayor en NP que en EP. No se encontraron diferencias de los niveles de CC16 en ambos grupos. Montelukast redujo la célula predominante en ambos subgrupos, mientras que budesonida sólo redujo los eosinófilos en EP. Tanto budesonida como montelukast redujeron PEFV en EP, pero no en NP. El nivel de CC16 aumentó significativamente en el EP luego del tratamiento antiinflamatorio. En conclusión: se identificó un subgrupo de asmáticos NP que presentan una menor labilidad bronquial, la vía de los leucotrienos parece estar involucrada y responde al tratamiento anti-leucotrienos. Este fenotipo muestra una escasa recuperación del nivel de CC16 posterior al tratamiento.

  3. Hyperventilation, cerebral perfusion, and syncope

    DEFF Research Database (Denmark)

    Immink, R V; Pott, F C; Secher, N H;

    2014-01-01

    This review summarizes evidence in humans for an association between hyperventilation (HV)-induced hypocapnia and a reduction in cerebral perfusion leading to syncope defined as transient loss of consciousness (TLOC). The cerebral vasculature is sensitive to changes in both the arterial carbon di...

  4. Efectos del extracto de semillas de uva sobre la cistopatia diabética inducida por estreptozotocina en ratas

    Directory of Open Access Journals (Sweden)

    María Lourdes Arruzazabala

    2010-01-01

    aisladas de vejiga de rata, pero impidió completamente el aumento de las concentraciones séricas de creatinina inducido por STZ.

  5. Cerebral Hemorrhage and APOE genotype

    Institute of Scientific and Technical Information of China (English)

    Sun xiaojiang; Wu ping; Zhang jing; Lu shanqing; Li bing

    2000-01-01

    Background and Purpose: Current evidence Suggests that the apolipoprotein E (APOE)ε 4 allele predisposes to cerebral amyloid angiopathy (CAA) whereas ε 2 is associated with CAA-zelated hemorrhage. In this study we examined potential clinical risk factors inpatients with cerebral hemorrhage and assessed these with respect to APOE genotype. Methoeds: 146 patinas with cerebral hemorrhage and 70 normal controls were investigated. APOE genotypes were determined with use of polymerase Chain reaction techniques.Results: The frequency of allele gene ( 0.180 ) and the percentage of the APOE ε 4 genotype in the cerebral hemorrhage group were Significantly higher as compared with the e 4 prequency ( O.O72 ) in the control group respectively ( p=O.O389 ) .Conelusious: APOE ε 4 :allele is a risk gene for cerebral hemorrhage.

  6. Therapeutic interventions in cerebral palsy.

    Science.gov (United States)

    Patel, Dilip R

    2005-11-01

    Various therapeutic interventions have been used in the management of children with cerebral palsy. Traditional physiotherapy and occupational therapy are widely used interventions and have been shown to be of benefit in the treatment of cerebral palsy. Evidence in support of the effectiveness of the neurodevelopmental treatment is equivocal at best. There is evidence to support the use and effectiveness of neuromuscular electrical stimulation in children with cerebral palsy. The effectiveness of many other interventions used in the treatment of cerebral palsy has not been clearly established based on well-controlled trials. These include: sensory integration, body-weight support treadmill training, conductive education, constraint-induced therapy, hyperbaric oxygen therapy, and the Vojta method. This article provides an overview of salient aspects of popular interventions used in the management of children with cerebral palsy. PMID:16391455

  7. Cerebral hemodynamics in moyamoya disease

    International Nuclear Information System (INIS)

    Rebuild-up phenomenon, an electroencephalographic pathological finding in moyamoya disease, was evaluated in the context of dynamic changes in cerebral circulation after hyperventilation. Sequential functional angiography after hyperventilation, measurement of cerebral blood flow (CBF) by the outflow method, and Kr-81m single photon emission tomography were employed for clarification of the sequential dynamic changes in cerebral circulation after hyperventilation. In most cases there was a persistent decrease in CBF even after arterial carbon dioxide tension (PaCO2) had been normalized, which suggests that the response of the cerebral circulation to the changes in PaCO2 is delayed. Moreover, this feature was most prominent in the superficial layer of the cerebrum. For the most part, coincidence and synchronization were documented between rebuild-up and the delayed response of the cerebral circulation. These findings indicate that the delayed CBF response to hyperventilation contributes pathogenetically to rebuild-up in moyamoya disease. (author)

  8. Anormalidades de fluxo sangüíneo cerebral em indivíduos dependentes de cocaína Cerebral blood flow abnormalities in cocaine dependent subjects

    OpenAIRE

    Sergio Nicastri; Buchpiguel, Carlos A.; Andrade, Arthur G.

    2000-01-01

    INTRODUÇÃO: Nos últimos anos, tem havido relatos de anormalidades do fluxo sanguíneo cerebral em indivíduos com o abuso de cocaína, detectadas por meio de tomografia computadorizada por emissão de fóton único (SPECT). Esse padrão anormal de perfusão cerebral tem sido associado a prejuízos cognitivos mas não a alterações observáveis por meio de exames de neuroimagem estrutural. Um problema envolvendo a maioria dos trabalhos publicados sobre esse tema é a inclusão de um grande número de usuário...

  9. Cerebral imaging in pediatrics

    International Nuclear Information System (INIS)

    Radioisotope brain imaging has focused mainly on regional cerebral blood flow (rCBF). However the use of ligand which go to specific receptor sites is being introduced in pediatrics, mainly psychiatry. rCBF is potentially available in many institutions, especially with the availability of multi-headed gamma cameras. The use of this technique in pediatrics requires special attention to detail in the manner of data acquisition and handling the child. The interpretation of the rCBF study in a child requires knowledge of normal brain maturation. The major clinical use in pediatrics is epilepsy because of the advances in surgery and the frequency of complex partial seizures. Other indications in pediatric neurology include brain death, acute neurological loss including stroke, language disorders, cerebral palsy, hypertension due to renovascular disease, traumatic brain injury and migraine. There are pediatric physiological conditions in which rCBF has been undertaken, these include anorexia nervosa, autism, Gilles de la Tourette syndrome (GTS) and attention deficit disorder-hyperactivity (ADHD). Research using different ligands to specific receptor sites will also be reviewed in pediatrics

  10. Cerebral cartography and connectomics.

    Science.gov (United States)

    Sporns, Olaf

    2015-05-19

    Cerebral cartography and connectomics pursue similar goals in attempting to create maps that can inform our understanding of the structural and functional organization of the cortex. Connectome maps explicitly aim at representing the brain as a complex network, a collection of nodes and their interconnecting edges. This article reflects on some of the challenges that currently arise in the intersection of cerebral cartography and connectomics. Principal challenges concern the temporal dynamics of functional brain connectivity, the definition of areal parcellations and their hierarchical organization into large-scale networks, the extension of whole-brain connectivity to cellular-scale networks, and the mapping of structure/function relations in empirical recordings and computational models. Successfully addressing these challenges will require extensions of methods and tools from network science to the mapping and analysis of human brain connectivity data. The emerging view that the brain is more than a collection of areas, but is fundamentally operating as a complex networked system, will continue to drive the creation of ever more detailed and multi-modal network maps as tools for on-going exploration and discovery in human connectomics.

  11. Cerebral sinus venous thrombosis

    Directory of Open Access Journals (Sweden)

    Hernando Raphael Alvis-Miranda

    2013-01-01

    Full Text Available Cerebral sinus venous thrombosis (CSVT is a rare phenomenon that can be seen with some frequency in young patients. CSVT is a multifactorial condition with gender-related specific causes, with a wide clinical presentation, the leading causes differ between developed and developing countries, converting CSVT in a condition characterized by a highly variable clinical spectra, difficult diagnosis, variable etiologies and prognosis that requires fine medical skills and a high suspicious index. Patients who presents with CSVT should underwent to CT-scan venography (CVT and to the proper inquiry of the generating cause. This disease can affect the cerebral venous drainage and related anatomical structure. The symptoms may appear in relation to increased intracranial pressure imitating a pseudotumorcerebri. Prognosis depends on the early detection. Correcting the cause, generally the complications can be prevented. Mortality trends have diminished, and with the new technologies, surely it will continue. This work aims to review current knowledge about CSVT including its pathogenesis, etiology, clinical manifestations, diagnosis, and treatment.

  12. Cerebral imaging in pediatrics

    Energy Technology Data Exchange (ETDEWEB)

    Gordon, I. [London, Great Ormond Street Hospital for Children (United Kingdom)

    1998-06-01

    Radioisotope brain imaging has focused mainly on regional cerebral blood flow (rCBF). However the use of ligand which go to specific receptor sites is being introduced in pediatrics, mainly psychiatry. rCBF is potentially available in many institutions, especially with the availability of multi-headed gamma cameras. The use of this technique in pediatrics requires special attention to detail in the manner of data acquisition and handling the child. The interpretation of the rCBF study in a child requires knowledge of normal brain maturation. The major clinical use in pediatrics is epilepsy because of the advances in surgery and the frequency of complex partial seizures. Other indications in pediatric neurology include brain death, acute neurological loss including stroke, language disorders, cerebral palsy, hypertension due to renovascular disease, traumatic brain injury and migraine. There are pediatric physiological conditions in which rCBF has been undertaken, these include anorexia nervosa, autism, Gilles de la Tourette syndrome (GTS) and attention deficit disorder-hyperactivity (ADHD). Research using different ligands to specific receptor sites will also be reviewed in pediatrics.

  13. Efectos tóxicos producidos por las microcistinas en peces

    Directory of Open Access Journals (Sweden)

    AI Prieto

    2008-01-01

    Full Text Available Las microcistinas (MC son toxinas peptídicas producidas, generalmente en medios acuáticos eutróficos, por distintos géneros de cianobacterias, destacando como una de las principales especies productoras Microcystis aeruginosa. Estructuralmente, las MC son heptapéptidos cíclicos y funcionalmente están clasificadas dentro del grupo de las hepatotoxinas. Las MC han originado intoxicaciones a veces incluso fatales tanto en animales como en humanos, por lo que están consideradas como un problema ambiental, ecotoxicológico y principalmente sanitario, destacando su posible actividad carcinógenica. Se ha establecido una Ingesta Diaria Tolerable (IDT provisional de 0,04 µg/Kg/día de equivalentes de MC-LR y en relación con este valor guía, se considera que la exposición a MC por consumo de alimentos puede ser del orden del 20%, una vez reconocida su bioacumulación en algunos tejidos de plantas, moluscos y pescados, ya que las cianobacterias son un importante componente de la dieta de muchos peces cíclidos tropicales y ciprínidos. Son diversos los estudios de campo que demuestran la acumulación de MC en pescados, procedentes de lagos con floraciones de cianobacterias tóxicas, incluso en periodos de baja densidad fitoplanctónica, pudiéndose alcanzar valores muy próximos a la IDT anteriormente mencionada. Al ser los peces uno de los organismos más proclives a las intoxicaciones por MC y acumularlas, en los últimos años se ha constatado un aumento considerable de las publicaciones científicas sobre los daños fisiopatológicos inducidos por las mismas a nivel macroscópico, histológico, ultraestructural y metabólico en peces, en función de la especie piscícola, lo que justifica su revisión

  14. Cerebrovascular hemodynamics in patients with cerebral arteriosclerosis

    Institute of Scientific and Technical Information of China (English)

    Jianbo Yang; Changcong Cui; Chengbin Wu

    2011-01-01

    The present study observed hemodynamic changes in 26 patients with cerebral arteriosclerosis using a cerebral circulation dynamics detector and transcranial Doppler.In patients with cerebral arteriosclerosis the blood supply and flow rate in the bilateral carotid arteries and the blood flow rate in the anterior cerebral and middle cerebral arteries were similar to normal controls, but the cerebral vascular resistance, critical pressure and pulsatility index were increased, and cerebral arterial elasticity and cerebral blood flow autoregulation were decreased.Compared with the lesioned hemisphere of patients with cerebral infarction, the total blood supply and blood flow rate of patients with cerebral arteriosclerosis were higher.Compared with normal subjects, patients with cerebral arteriosclerosis exhibited cognitive disturbances, mainly in short-term memory, attention, abstract capability, and spatial and executive dysfunction.Results showed that cerebral arteriosclerosis does not directly affect the blood supply of a cerebral hemisphere, but affects cognitive function.The increased cerebral vascular resistance and reduced autoregulation of cerebral blood vessels may be important hemodynamic mechanisms of arteriosclerosis-induced cerebral infarction.

  15. Mifepristone inhibits MPA-and FGF2-induced mammary tumor growth but not FGF2-induced mammary hyperplasia La mifepristona inhibe el crecimiento de carcinomas mamarios inducidos por MPA o por FGF2 pero no las hiperplasias mamarias inducidas por FGF2

    OpenAIRE

    Cerliani, Juan P.; Sebastián Giulianelli; Ana Sahores; Victoria Wargon; Adrián Gongora; Alberto Baldi; Alfredo Molinolo; Lamb, Caroline A.; Claudia Lanari

    2010-01-01

    We have previously demonstrated a crosstalk between fibroblast growth factor 2 (FGF2) and progestins inducing experimental breast cancer growth. The aim of the present study was to compare the effects of FGF2 and of medroxyprogesterone acetate (MPA) on the mouse mammary glands and to investigate whether the antiprogestin RU486 was able to reverse the MPA- or FGF2-induced effects on both, mammary gland and tumor growth. We demonstrate that FGF2 administered locally induced an intraductal hyper...

  16. CEREBRAL PALSY AND MUSIC ACHIEVEMENT

    Directory of Open Access Journals (Sweden)

    Miodrag L. STOSHLJEVIKJ

    2008-12-01

    Full Text Available Pupils with cerebral palsy attend elementary education accordind to a regular and special teaching plan and program. Regular school curriculum was reformed in 1992, while special plan and program has not been changed and adapted according to pupil’s needs and capacities. Music is one of the best means of expressing oneself and plays a very important role in the development of every child, the child with cerebral palsy in particular.In order to test the possibility of pupils with cerebral palsy, with and without mental retardation, to apprehend the actual program content, we have conducted research on musical achievement of children with cerebral palsy. During 2007 a research was carried out, on the sample of 27 pupils with cerebral palsy and mild mental retardation who attended classes in the school “Miodrag Matikj”, and a sample of16 students with cerebral palsy without mental retardation who attended the school “Dr. Dragan Hercog” in Belgrade.Results of the research, as well as analysis of music curriculum content, indicated that the capacities of students with cerebral palsy to carry out the curriculum tasks require special approach and methodology. Therefore, we introduced some proposals to overcome the difficulties in fulfilling music curriculum demands of those pupils. We made special emphasis on the use of computer based Assistive technology which facilitates the whole process to a large extent.

  17. CEREBRAL PALSY : ANTENATAL RISK FACTORS

    Directory of Open Access Journals (Sweden)

    Srinivasa Rao

    2015-05-01

    Full Text Available INTRODUCTION: Cerebral palsy (CP is a group of permanent movement disorders that appear in early childhood. Cerebral palsy is caused by abnormal development or damage to the parts of the brain that control movement, balance, and posture. Most often the problems occur during pregnancy; however, they may also occur during childbirth, or shortly after birth. Often the cause is unknown. AIM: To study the different antenatal maternal risk factors associated with cerebral palsy in the study group. MATERIA LS AND METHODS: Retrospective study was done to assess possible associated antenatal risk factors for cerebral palsy. Mothers of 100 cerebral palsy children were selected who are treated in Rani Chandramani Devi Hospital, a Government hospital in Visakhapa tn am, Andhra Pradesh State, India , from 2012 to 2014 and 100 controls, mothers of normal children were studied. Detailed antenatal history was obtained from the mothers of the children in both affected and control group. RESULTS: From the data, we conclude that the association of maternal anaemia with cerebral palsy is 7.3 times higher; association of maternal hypertension with cerebral palsy is 6.6 time higher, association with Pre - eclampsia is 6 times higher; association with Eclampsia is 8.6 times higher ; with antepartum haemorrhage, the association is 8.6 times higher and association of multiple pregnancy with cerebral palsy is 4.8 times higher than with controls. CONCLUSION: From this study of the role of antenatal risk factors, in the occurrence of cer ebral palsy in children it is concluded that the most common risk factor associated with cerebral palsy is the maternal anaemia and the other important risk factors associated being hypertension, pre eclampsia, eclampsia, antepartum haemorrhage and multipl e births.

  18. Osteomielitis por salmonella

    Directory of Open Access Journals (Sweden)

    Alicia Velázquez Pérez

    2014-08-01

    Full Text Available Se presenta el caso de una paciente femenina de color blanco y dos años de edad, con diagnóstico prenatal de sicklemia, que desde edades tempranas tiene problemas de la enfermedad. Ingresó en esta ocasión por una de las complicaciones infecciosas que ocasiona este padecimiento, una osteomielitis del húmero izquierdo, aislándose el germen en el hemocultivo realizado, una salmonella. Necesitó de tratamiento enérgico y prolongado; se obtuvo un resultado satisfactorio en la evolución de la enfermedad y se sigue sistemáticamente por consulta externa en la actualidad

  19. CEREBRAL PALSY AND MUSIC ACHIEVEMENT

    OpenAIRE

    Miodrag L. STOSHLJEVIKJ; EMINOVIKJ Fadilj N.; NIKIKJ Radmila M.; Gordana I. ACHIKJ; Sanela R. PACIKJ

    2015-01-01

    Pupils with cerebral palsy attend elementary education accordind to a regular and special teaching plan and program. Regular school curriculum was reformed in 1992, while special plan and program has not been changed and adapted according to pupil’s needs and capacities. Music is one of the best means of expressing oneself and plays a very important role in the development of every child, the child with cerebral palsy in particular.In order to test the possibility of pupils with cerebral pal...

  20. Dermatitis canina por Malassezia

    Directory of Open Access Journals (Sweden)

    Rejas López, Juan

    2008-05-01

    Full Text Available La dermatitis por Malassezia en perros en generalmente una complicación a procesos alérgicos, seborreicos, presencia de pliegues, etc. aunque también se han descrito otras presentaciones, como la hipersensibilidad contra esta levadura. La demostración de la presencia de Malassesia pachydermatis se hace de manera sencilla mediante citología. El tratamiento de esta dermatitis puede ser tópico u oral.

  1. Dermatitis canina por Malassezia

    OpenAIRE

    Rejas López, Juan

    2008-01-01

    La dermatitis por Malassezia en perros en generalmente una complicación a procesos alérgicos, seborreicos, presencia de pliegues, etc. aunque también se han descrito otras presentaciones, como la hipersensibilidad contra esta levadura. La demostración de la presencia de Malassesia pachydermatis se hace de manera sencilla mediante citología. El tratamiento de esta dermatitis puede ser tópico u oral.

  2. causada por Fusarium moniliforme

    Directory of Open Access Journals (Sweden)

    Mariano Mendoza Elos

    2006-01-01

    Full Text Available El objetivo de éste trabajo fue determinar la resistencia horizontal de 134 líneas S1 de maíz al hongo Fusarium moniliforme. La enfermedad fue inducida mediante inoculación en la etapa de floración masculina bajo condiciones de campo utilizando la técnica del palillo. Las líneas se evaluaron en México en 2002. La estimación de la enfermedad se hizo en dos ocasiones con una separación de 20 días. Las evaluaciones mostraron que las líneas Roque-801, 804, 1103 y 1405 fueron resistentes en la primera evaluación. Las tasas de incremento de la enfermedad variaron de 0,01 a 0,229 por unidad por día. Las líneas mostraron bajos niveles de enfermedad de 0 a 1 % en la primera evaluación. En la segunda evaluación, los niveles de enfermedad variaron de 49 a 100 %. En un programa de mejoramiento genético estas líneas pueden ser utilizadas para mejorar la resistencia horizontal del maíz a la pudrición del tallo causada por Fusarium moniliforme

  3. Cerebral toxoplasmosis in AIDS

    Energy Technology Data Exchange (ETDEWEB)

    Christ, F.; Steudel, H.; Klotz, D.

    1986-02-01

    Since 1982 (Hauser and co-workers), literature has reported focal cerebral tissue charges in AIDS patients whose diagnosis was unclear at first but which could be identified finally as florid toxoplasmosis encephalitis by biopsy and autopsy. It was found that the value of otherwise reliable serological tests (KBR, Sabin-Feldmann tests, etc.) is questionable in patients with severely impaired or incompetent immune systems, and, in particular, that a negative or uncharacteristic test result may not preclude any opportunistic infection process. Furthermore, isolation of Toxoplasma gondii or specific antibodies from the cerebrospinal fluid will be successful in exceptional cases only. In patients with AIDS or lymphadenopathy syndrome, the differential diagnosis will have to include - first and foremost - reactivated toxoplasma infection (not newly acquired, as a rule) if central neurological symptoms occur.

  4. Cerebral white matter hypoplasia

    International Nuclear Information System (INIS)

    This paper demonstrates the MR imaging findings in children with cerebral white matter hypoplasia (CWMH). The MR studies of four children, aged 3-7 y (mean age, 2.3 y) with a diagnosis of CWMH were reviewed. In all cases multiplanar T1-weighted and T2-weighted spin-echo images were obtained. All children had similar histories of severe developmental delay and nonprogressive neurologic deficits despite normal gestational and birth histories. In two cases there was a history of maternal cocaine abuse. Autopsy correlation was available in one child. The MR images of all four children demonstrated diffuse lack of white matter and enlarged ventricles but normal-appearing gray matter. The corpus callosum, although completely formed, was severely thinned. There was no evidence of gliosis or porencephaly, and the distribution of myelin deposition was normal for age in all cases. Autopsy finding in one child correlated exactly with the MR finding

  5. Cerebral oxygenation after birth

    DEFF Research Database (Denmark)

    Hessel, Trine W; Hyttel-Sorensen, Simon; Greisen, Gorm

    2014-01-01

    AIM: To compare absolute values of regional cerebral tissue oxygenation (cStO2 ) during haemodynamic transition after birth and repeatability during steady state for two commercial near-infrared spectroscopy (NIRS) devices. METHODS: In a prospective observational study, the INVOS 5100C and FORE......-SIGHT were compared on 12 term newborns delivered by elective caesarean section. During the 10 min following umbilical cord clamping, cStO2 was measured simultaneously with the neonatal sensors from each device. Repeated measurements were taken the following day. RESULTS: Three and 8 min after clamping......: The INVOS and FORE-SIGHT cStO2 estimates showed oxygenation-level-dependent difference during birth transition. The better repeatability of FORE-SIGHT could be due to the lower response to change in saturation....

  6. Efectividad de la ivermectina en un modelo de disquinesia tardía inducida por haloperidol en ratas

    Directory of Open Access Journals (Sweden)

    Mauricio Palacios

    2008-09-01

    Full Text Available Introducción: Los síntomas extrapiramidales y en especial las disquinesias tardías, son la mayor limitante de la terapia con antipsicóticos, debido a la frecuencia de aparición durante el tratamiento y la falta de recursos para controlar estas reacciones adversas, por lo cual es necesario investigar nuevos recursos para el manejo de las disquinesias tardías.Objetivo: Evaluar el efecto de la ivermectina sobre las disquinesias tardías inducidas por haloperidol en ratas.Métodos: En un modelo de dosis única de haloperidol con ratas Sprague Dawley, se evalúo la capacidad de la ivermectina para evitar cambios en la conducta motora y la aparición de movimientos anormales. Adicionalmente, se implementó un modelo animal crónico conocido como VCM (vacuous chewing movements, donde se evaluó la frecuencia de movimientos orofaciales durante seis meses, al recibir simultáneamente haloperidol e ivermectina a dosis diferentes, comparándolo con un grupo control y otro grupo al que se le administró haloperidol.Resultados: La ivermectina no evitó los cambios inducidos por haloperidol en el comportamiento motor, ni la aparición de movimientos anormales en el modelo agudo. Tampoco modificó la frecuencia de movimientos orofaciales en el modelo de administración crónica de haloperidol. La ivermectina no indujo cambios en la conducta motora, ni la aparición de movimientos anormales en los modelos agudo y crónico.Conclusiones: Los hallazgos de este trabajo descartan a la ivermectina como candidata para el manejo de las disquinesias tardías y no permite aportar argumentos a la hipótesis GABAérgica en la fisiopatología de las disquinesias tardías. Adicionalmente, la ivermectina no induce movimientos anormales.

  7. Detección y estudio mediante Fluorescencia Inducida por Láser de radicales libres formados por Disociación Multifotónica Infrarroja

    Science.gov (United States)

    Santos, M.; Díaz, L.; Torresano, J. A.; Rubio, L.; Samoudi, B.

    Una de las principales aplicaciones actuales de los procesos de disociación multifotónica inducidos por radiación láser infrarroja (DMI) es la producción de radiales libres, con el fin de estudiar sus propiedades cinéticas y espectroscópicas. La disociación de moléculas poliatómicas en el IR con láseres de CO2 tiene lugar desde la superficie de energía molecular mas baja y conduce generalmente a la formación de fragmentos en el estado electrónico fundamental, con diversos grados de excitación vibracional. En el Grupo de Procesos Multifotónicos del Instituto de Estructura de la Materia del C.S.I.C. hemos puesto a punto la técnica de Fluorescencia Inducida por Láser (LIF) para la detección y análisis en tiempo real de los fragmentos producidos en la DMI inducida mediante uno o dos campos láseres de diferentes longitudes de onda. Objetivos de nuestro trabajo han sido el estudio de los canales de disociación mayoritarios y de las especies transitoria producidas, así como de la distribución de energía interna con que éstas son generadas. En particular hemos detectado mediante LIF las especies: C2, CF, CH, SiH2, CF2, CH2, SiHCl, y CF3 a partir de la disociación de, entre otras, las siguientes moléculas: C2H3Br, C3F6, C4H8Si, C2H5ClSi y CH5ClSi. En este trabajo presentamos algunos de los resultados obtenidos mediante el estudio por LIF de estos radicales: estudio temporal de la señal LIF obtenida con determinación de tiempos de vida, espectros de excitación y fluorescencia, temperaturas vibracionales de formación, variación de la intensidad LIF con el tiempo de retraso entre los láseres de disociación y prueba, etc.

  8. Anestesia e paralisia cerebral Anestesia y parálisis cerebral Anesthesia and cerebral palsy

    OpenAIRE

    Március Vinícius M Maranhão

    2005-01-01

    JUSTIFICATIVA E OBJETIVOS: A paralisia cerebral (PC) é uma doença não progressiva decorrente de lesão no sistema nervoso central, levando a um comprometimento motor do paciente. O portador de PC freqüentemente é submetido a procedimentos cirúrgicos devido a doenças usuais e situações particulares decorrentes da paralisia cerebral. Foi objetivo deste artigo revisar aspectos da paralisia cerebral de interesse para o anestesiologista, permitindo um adequado manuseio pré, intra e pós-operatório n...

  9. Learn More About Cerebral Palsy

    Centers for Disease Control (CDC) Podcasts

    2008-03-30

    This podcast describes the causes, preventions, types, and signs and symptoms of cerebral palsy.  Created: 3/30/2008 by National Center on Birth Defects and Developmental Disabilities.   Date Released: 3/21/2008.

  10. SÍNTESIS DE ÓXIDOS CONDUCTORES TRANSPARENTES DE ÓXIDO DE ZINC DOPADO CON ALUMINIO POR COPRECIPITACIÓN QUÍMICA

    Directory of Open Access Journals (Sweden)

    Silvia Maioco

    2013-01-01

    Full Text Available Los óxidos de zinc dopados con Al (AZO son promisorios reemplazantes de los óxidos de indio dopados con Sn (ITO pero sus películas delgadas muestran un amplio rango de propiedades fuertemente dependientes de las condiciones del proceso de deposición. Se examinan cerámicos de granulometría submicrométrica de óxido de zinc dopado con 1% de aluminio, preparados por coprecipitación en solución acuosa, a partir de Zn(NO32 y Al(NO33, sinterizados a 1200°C y subsecuentemente templados en atmósfera controlada de 10-16 atm de oxígeno, a 1000°C. La resistividad eléctrica disminuye en dos órdenes de magnitud en las primeras dos horas de templado y el coeficiente Seebeck cambia de -140 a -50 μV/K gradualmente en 8 h. Se concluye que el aumento de la movilidad domina sobre el de densidad de portadores, inducido por cambios de la estequiometria metal oxígeno.

  11. Cerebral palsy: classification and etiology

    OpenAIRE

    Bialik, Gad M.; Givon, Uri

    2004-01-01

    Cerebral palsy (CP), a common condition of abnormalities in the brain, arises early in life. Since the term was first introduced in 1843, many authors have tried to define and classify CP. The most recent definition was released by the American Academy for Cerebral Palsy and Developmental Medicine (AACPDM) in 2005. This article summarizes the latest and familiar classifications of, and etiologies associated with CP.

  12. CEREBRAL PALSY : ANTENATAL RISK FACTORS

    OpenAIRE

    Srinivasa Rao; Vidyullatha; Subbalakshmi

    2015-01-01

    INTRODUCTION: Cerebral palsy (CP) is a group of permanent movement disorders that appear in early childhood. Cerebral palsy is caused by abnormal development or damage to the parts of the brain that control movement, balance, and posture. Most often the problems occur during pregnancy; however, they may also occur during childbirth, or shortly after birth. Often the cause is unknown. AIM: To study the different antenatal maternal risk factors associated with cere...

  13. Bone age in cerebral palsy

    OpenAIRE

    Miranda, Eduardo Régis de Alencar Bona; Palmieri, Maurício D'arc; de Assumpção, Rodrigo Montezuma César; Yamada, Helder Henzo; Rancan, Daniela Regina; Fucs, Patrícia Maria de Moraes Barros

    2013-01-01

    Objective To compare the chronological age and bone age among cerebral palsy patients in the outpatient clinic and its correlation with the type of neurological involvement, gender and functional status. Methods 401 patients with spastic cerebral palsy, and ages ranging from three months to 20 years old, submitted to radiological examination for bone age and analyzed by two independent observers according Greulich & Pyle. Results In the topographic distribution, there was a significant delay (p

  14. Sirt1 in cerebral ischemia

    OpenAIRE

    Koronowski, Kevin B.; Perez-Pinzon, Miguel A.

    2015-01-01

    Cerebral ischemia is among the leading causes of death worldwide. It is characterized by a lack of blood flow to the brain that results in cell death and damage, ultimately causing motor, sensory, and cognitive impairments. Today, clinical treatment of cerebral ischemia, mostly stroke and cardiac arrest, is limited and new neuroprotective therapies are desperately needed. The Sirtuin family of oxidized nicotinamide adenine dinucleotide (NAD+)-dependent deacylases has been shown to govern seve...

  15. Cerebral candidiasis. Computed tomography appearance

    Energy Technology Data Exchange (ETDEWEB)

    Chaabane, M.; Ladeb, M.F.; Bouhaouala, M.H.; Ben Hammouda, M.; Ataalah, R.; Gannouni, A.; Krifa, H.

    1989-07-01

    A three year old child who had been suffering from oral candidiasis since the age of 1 year presented with osteitis of the clavicle, 2 cerebral frontal abscesses and an occipital abscess which extended across the calvaria and was associated with osteolysis. Histological and microbiological studies following surgery confirmed the diagnosis of candidiasis in this girl who was found to have IgA immunodefinciency. The authors report the computed tomographic appearance of the cerebral lesions and review the literature. (orig.).

  16. Cerebral candidiasis. Computed tomography appearance

    International Nuclear Information System (INIS)

    A three year old child who had been suffering from oral candidiasis since the age of 1 year presented with osteitis of the clavicle, 2 cerebral frontal abscesses and an occipital abscess which extended across the calvaria and was associated with osteolysis. Histological and microbiological studies following surgery confirmed the diagnosis of candidiasis in this girl who was found to have IgA immunodefinciency. The authors report the computed tomographic appearance of the cerebral lesions and review the literature. (orig.)

  17. O estímulo emocional na criança com paralisia cerebral na perspetiva dos professores

    OpenAIRE

    Coutinho, Maria Alexandra dos Santos

    2013-01-01

    O presente trabalho tem como tema “O estímulo emocional na criança com paralisia cerebral, na perspetiva dos professores”. Para realizar o objetivo proposto, efetuou-se este trabalho, que é constituído por um Enquadramento Teórico e por um Enquadramento Empírico onde se realiza a apresentação, análise e respetiva discussão dos resultados, os limites do projeto e prospetiva de divulgação. No Enquadramento Teórico, é apresentado o conceito de Paralisia Cerebral, segundo vários autores. São a...

  18. Intrathecal treatment of cerebral vasospasm.

    Science.gov (United States)

    Zhang, Yi Ping; Shields, Lisa B E; Yao, Tom L; Dashti, Shervin R; Shields, Christopher B

    2013-11-01

    Treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) remains a major therapeutic challenge. Systemic drug administration is the current treatment of choice, but patients often do not respond beneficially to this approach. Intrathecal (IT) drug administration has several anatomic and pharmacodynamic advantages over conventional systemic treatment of cerebral vasospasm. We reviewed the most recent literature describing IT administration of several drugs to treat aneurysm-induced SAH and cerebral vasospasm, including 16 clinical trials using IT fibrinolytic agents and 10 trials using several IT vasodilators. We evaluated the safety and effectiveness of these trials but made no attempt to perform a meta-analysis using these data. IT drug administration of fibrinolytic agents and vasodilators caused lysis of the subarachnoid clot burden and diminished cerebral vasospasm, respectively. The studies reviewed reported a wide range of drug doses, intervals between aneurysm hemorrhage and initiation of treatment, success of clot dissolution, and degree of vasodilation of vessels in vasospasm. Treatment of vasospasm by IT drug administration is safe and largely effective after the aneurysm has been secured. Our findings indicate that IT treatment effectively delivers a higher drug concentration to vessels in vasospasm with minimal systemic effects. Drugs administered by this route are reported to lyse subarachnoid clots, attenuate cerebral vasospasm, improve clinical outcomes, and decrease the incidence of hydrocephalus. With greater understanding of drug pharmacodynamics, the IT route of drug administration may provide a rational, alternative approach to treating aneurysm-induced cerebral vasospasm. PMID:22651990

  19. Miotoxicidade por organofosforados

    Directory of Open Access Journals (Sweden)

    Cavaliere Maria J.

    1996-01-01

    Full Text Available Os organofosforados são um grupo de compostos químicos amplamente utilizados em agropecuária como inseticidas, ocasionando intoxicações acidentais em animais e humanos, e mesmo sendo utilizados em tentativas de suicídio. A toxicidade desses produtos decorre sobretudo de insuficiência cárdio-respiratória por compromentimento do sistema nervoso autônomo. Sabe-se que alguns destes compostos induzem em animais de experimentação e em humanos, uma miopatia caracterizada por degeneração de células musculares, comprometendo sobretudo a musculatura respiratória. Baseado no fato de que este comprometimento contribui para a piora da função respiratória, propõe-se um protocolo de avaliação rotineira de miotoxicidade por compostos organofosforados, através de uma bateria mínima e suficiente de colorações e reações histoquímicas para quantificação da necrose muscular. Utilizaram-se como modelo experimental, grupos de ratos albinos (Wistar intoxicados com o organofosforado paraoxon, com e sem antídotos (atropina ou pralidoxima. Verificou-se nos grupos tratados com paraoxon e paraoxon mais atropina, necrose de fibras musculares no diafragma, que atingia em determinadas áreas até 15% das fibras. No grupo tratado com paraoxon mais pralidoxima, a necrose foi mínima, evidenciando o papel mioprotetor deste último antídoto.

  20. Monitoring of cerebral haemodynamics in newborn infants

    DEFF Research Database (Denmark)

    Liem, K Djien; Greisen, Gorm

    2010-01-01

    The most important cerebrovascular injuries in newborn infants, particularly in preterm infants, are cerebral haemorrhage and ischemic injury. The typical cerebral vascular anatomy and the disturbance of cerebral haemodynamics play important roles in the pathophysiology. The term 'cerebral...... haemodynamics' includes cerebral blood flow (CBF), cerebral blood flow velocity, and cerebral blood volume (CBV). Therapy aimed at changing vascular anatomy is not available. Therefore, prevention of disturbances in CBF and CBV is pivotal. However, continuous monitoring of CBF and CBV is still unavailable for....... Using it even without knowing the exact level of CBF and CBV, it is possible to aim to keep CBF and CBV stable. Futureresearch should focus on development of monitoring tools, gaining more insight in neonatal cerebral autoregulation, and demonstrating clinical benefits of a 'cerebral perfusion...

  1. Por mil devaluados pesos

    Directory of Open Access Journals (Sweden)

    Annie Rodríguez Collázos

    2013-03-01

    Full Text Available El estudio de lo popular y lo urbano hasta ahora se ha centrado en el comportamiento y en algunas relaciones de los habitantes con su entorno. “Por mil devaluados pesos. Publicidad popular y urbana”, pretende explorar las formas de publicidad, dispersas en diferentes espacios populares y urbanos en Bogotá, identificando esquemas y formas características de sus propios códigos comunicativos; se centran en un objeto de estudio consistente en las estrategias publicitarias y los códigos comunicativos en los mensajes publicitarios populares en las subculturas de San Victorino, 7 de Agosto y Sanandresito de San José.

  2. Effects of Hyperglycemia and Effects of Ketosis on Cerebral Perfusion, Cerebral Water Distribution, and Cerebral Metabolism

    OpenAIRE

    Glaser, Nicole; Ngo, Catherine; Anderson, Steven; Yuen, Natalie; Trifu, Alexandra; O’Donnell, Martha

    2012-01-01

    Diabetic ketoacidosis (DKA) may cause brain injuries in children. The mechanisms responsible are difficult to elucidate because DKA involves multiple metabolic derangements. We aimed to determine the independent effects of hyperglycemia and ketosis on cerebral metabolism, blood flow, and water distribution. We used magnetic resonance spectroscopy to measure ratios of cerebral metabolites (ATP to inorganic phosphate [Pi], phosphocreatine [PCr] to Pi, N-acetyl aspartate [NAA] to creatine [Cr], ...

  3. Cerebral edema associated with acute hepatic failure.

    Directory of Open Access Journals (Sweden)

    Fujiwara,Masachika

    1985-02-01

    Full Text Available The clinicopathological findings of cerebral edema were investigated in patients with acute hepatic failure autopsied at Okayama University Hospital between 1970 and 1980 retrospectively. Nine (64% of 14 hepatic failure cases were found to have cerebral edema during a post-mortem examination of the brain. Clinical features of the patients with cerebral edema were not significantly different from those of the patients without cerebral edema. However, general convulsions were observed more frequently in patients later found to have cerebral edema. Moreover, the length of time from deep coma to death was much shorter in the brain edema cases with cerebral herniation than without herniation.

  4. Videojuego adaptado para personas con parálisis cerebral

    OpenAIRE

    Gómez Davó, Roberto

    2014-01-01

    La parálisis cerebral describe un grupo de trastornos del desarrollo psicomotor, que causan una limitación de la actividad de la persona, es decir, es un padecimiento que principalmente se caracteriza por la inhabilidad de poder controlar completamente las funciones del sistema motor. Esto puede incluir espasmos o rigidez en los músculos, movimientos involuntarios, y/o trastornos en la postura o movilidad del cuerpo. Estos trastornos psicomotores imposibilitan su interacción con los sistemas ...

  5. Cerebral trypanosomiasis and AIDS

    Directory of Open Access Journals (Sweden)

    Antunes Apio Claudio Martins

    2002-01-01

    Full Text Available A 36 year-old black female, complaining of headache of one month's duration presented with nausea, vomiting, somnolence, short memory problems, loss of weight, and no fever history. Smoker, intravenous drugs abuser, promiscuous lifestyle. Physical examination: left homonimous hemianopsia, left hemiparesis, no papilledema, diffuse hyperreflexia, slowness of movements. Brain CT scan: tumor-like lesion in the splenium of the corpus calosum, measuring 3.5 x 1.4 cm, with heterogeneous enhancing pattern, sugesting a primary CNS tumor. Due to the possibility of CNS infection, a lumbar puncture disclosed an opening pressure of 380 mmH(20; 11 white cells (lymphocytes; glucose 18 mg/dl (serum glucose 73 mg/dl; proteins 139 mg/dl; presence of Trypanosoma parasites. Serum Elisa-HIV tests turned out to be positive. Treatment with benznidazole dramatically improved clinical and radiographic picture, but the patient died 6 weeks later because of respiratory failure. T. cruzi infection of the CNS is a rare disease, but we have an increasing number of cases in HIV immunecompromised patients. Diagnosis by direct observation of CSF is uncommon, and most of the cases are diagnosed by pathological examination. It is a highly lethal disease, even when properly diagnosed and treated. This article intends to include cerebral trypanosomiasis in the differential diagnosis of intracranial space-occupying lesions, especially in immunecompromised patients from endemic regions.

  6. Asymptomatic ischemic cerebral lesions

    International Nuclear Information System (INIS)

    For the purpose of studying the incidence, pathomorphology and etiology of asymptomatic ischemic cerebral lesions, we carried out a brain MRI study on 65 patients with diabetes mellitus accompanied with hypertension who are thought to belong to a high risk group of ischemic cerebrovascular diseases. Excluding the abnormality of tendon reflex due to diabetic neuropathy, sixty percent of the total patients had some mild neurological signs and symptoms, most of them was discrepancy in tendon reflex. The percentage of the patients in whom MRI disclosed some abnormalities was as high as 70%, they were lacunar stroke, multiple lacunar state, cortical infarct, and patchy high signal lesions visible only in the T2 weighted image. Lacunes or these patchy high signal lesions (considered to be the dilatation of the perivascular space or true lacunes) tended to be found along the border zone or the terminal zone. These results indicate that asymptomatic patients in whom MRI discloses the abnormalities should be considered as candidates for the future onset of multi-infarct. (author)

  7. [Plasma osmolarity and cerebral volume].

    Science.gov (United States)

    Boulard, G

    2001-02-01

    Under normal physiological conditions, the osmolarity of extracellular fluids (ECFs) and natremia are controlled by two regulatory mechanisms modulating the water balance and sodium outflow from information collected by the osmoreceptors and baroreceptors, respectively. As well, under normal physiological conditions, water and electrolytes of brain ECFs are secreted by the endothelial cells of brain capillaries. Furthermore, isotonicity is present on both sides of the blood-brain barrier. In the event of systemic osmolarity disorders, water transport subject to osmosis laws occurs at the level of the blood-brain barrier. In the case of plasmatic hyperosmolarity cerebral dehydration is observed, while cerebral edema occurs in the contrary case. However, plasmatic osmolarity disorders have less effect on the cerebral volume when their introduction is slow. Experimentation in acute conditions shows that measured variations of the cerebral water content are lower than calculated variations, thus suggesting the existence of an adaptive mechanism, that is, the cerebral osmoregulation which limits the variation of the volume of brain cells by modulating their osmoactive molecule content. These osmoactive molecules are, on the one hand, the electrolytes, which are early and rapidly mobilized, and, on the other hand, the organic osmoles (amino acids, etc.), whose secretion is slower and delayed. This phenomenon should be taken into account in the treatment of osmolarity disorders. Thus, the related-risk of treatment for natremia disorders is therapeutic reversal of the osmotic gradient at the level of the blood-brain barrier. This reversal, which corresponds to a second osmotic stress, requires the implementation of a new procedure of cerebral osmoregulation in the opposite direction of the preceding one. As successive osmotic stresses decrease the effectiveness of brain osmoregulation, the risk for cerebral dehydration and pontine myelinolysis increases when the treatment

  8. Ojo por ojo

    OpenAIRE

    Ramón del Llano Ibáñez

    2011-01-01

    Nuestro pan y café de la mañana se acompaña de noticias alrededor de ejecuciones, de fosas clandestinas, de batallas del ejército, de balaceras en las calles y civiles caídos por balas perdidas : la muerte acompaña nuestro desayuno. Las calaveras de azúcar del día de muertos hoy son calaveras reales y amargas : 40 000 muertos en cuatro años después que el Presidente Calderón declaró la guerra a los narcotraficantes. Se han apresado a varios e importantes miembros de los cárteles : pero han si...

  9. Onicomicosis por hongos fuliginosos

    Directory of Open Access Journals (Sweden)

    Ingrid Salas-Campos

    2009-12-01

    Full Text Available Justificación y objetivo: Las infecciones de las uñas producidas por hongos son un problema de frecuente consulta dermatológica. Los dermatofitos son la mayor causa de estas infecciones, siendo Trichophyton rubrum el agente etiológico más importante. Sin embargo, los hongos no dermatofitos, tanto hialinos como fuliginosos, pueden ser también responsables de estos cuadros clínicos. Debido a que estos hongos tienden a ser resistentes a los antimicóticos comúnmente usados para tratar las onicomicosis, es que se hace indispensable que el clínico se asegure por medio de un examen de laboratorio de la etiología de la infección. Métodos: Se estudiaron tres casos de pacientes con lesiones en uñas, que acudieron al laboratorio de Micología Médica, Facultad de Microbiología, Universidad de Costa Rica. Se realizaron los análisis de rutina para aislamiento e identificación de hongos patógenos. Resultados: En los tres casos estudiados se observó al examen directo micelio fuliginoso. En uno de los casos se aisló e identificó Scytalidium dimidiatum, hongo que presenta resistencia a los antifúngicos utilizados para tratar onicomicosis. Conclusión. El reporte de hongos diferentes a los dermatofitos como agentes etiológicos de onicomicosis es importante para que el médico pueda elegir el tratamiento más recomendado para este tipo de infección.

  10. Motivado por cirujanos

    Directory of Open Access Journals (Sweden)

    Carlos Salazar-Vargas

    2010-12-01

    Full Text Available Comenzaba la década de los 60 y nuestro grupo nerviosamente iniciaba lecciones en los hospitales de San José. En aquellos años, el estudiante de medicina empezaba su contacto con pacientes, por lo menos 1 ó 2 años después de iniciada la carrera. El estudio del ser humano normal que ya habíamos concluido, continuaba con el del enfermo, y más adelante aprenderíamos el tratamiento. La enfermedad descrita en el libro, de pronto se convertía en un enfermo, y es a este quien hoy veíamos, cohibido pero inquisidor, en la cama de un hospital. Los profesores nos enseñaban a interrogar y a examinar a los pacientes, y cada gesto suyo, cada pregunta, cada maniobra, eran celosamente guardados en la memoria de los educandos. Con claridad percibíamos, aun a temprana edad, las diferencias entre los especialistas, y casi de manera involuntaria, cada quien iba tomando partido y escogía su futuro camino. Fue durante esos tempranos años, cuando mi vida se cruzó con la de 7 maravillosas personas y excelentes cirujanos, que marcaron para siempre mi destino y, sin quererlo ellos, me hicieron inclinarme por la cirugía. Dos eran serios y profundamente académicos: el Dr. Manuel Aguilar Bonilla y el Dr. Vesalio Guzmán Calleja; 3, decididos, incansables y muy hábiles: el Dr. Longino Soto Pacheco, el Dr. Claudio Orlich Carranza y el Dr. Carlos Prada Díaz, y 2, abordables, prácticos, joviales y amistosos: el Dr. Fernando Valverde Soley y el Dr. Randall Ferris Iglesias….

  11. What You Should Know about Cerebral Aneurysms

    Science.gov (United States)

    ... T. Quiz 5 Things to Know About Stroke What You Should Know About Cerebral Aneurysms Updated:Jun ... Damage Treatments Click image to view an animation What is a cerebral aneurysm? An aneurysm is a ...

  12. Middle cerebral artery blood velocity during rowing

    DEFF Research Database (Denmark)

    Secher, Niels Henry; Pott, F; Knudsen, L.;

    1997-01-01

    original,arterial blood pressure,central venous pressure,cerebral blood flow, exercise, transcranial Doppler......original,arterial blood pressure,central venous pressure,cerebral blood flow, exercise, transcranial Doppler...

  13. Dynamic Cerebral Autoregulation after Cardiopulmonary Bypass

    DEFF Research Database (Denmark)

    Christiansen, Claus Behrend; Berg, Ronan M G; Plovsing, Ronni;

    2016-01-01

    Background Cerebral hemodynamic disturbances in the peri- or postoperative period may contribute to postoperative cognitive dysfunction (POCD) in patients undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB). We therefore examined dynamic cerebral autoregulation (d...

  14. Primary cerebral lymphoma

    International Nuclear Information System (INIS)

    The aim of this study is to compare the survival of the patients treated with radiotherapy alone vs. patients treated with a combined schedule of radio-chemotherapy. Our results will be compared with currently published data and main prognostic factors will be briefly discussed. Patients and methods: Between 1974 and 1990, 27 cases of primary cerebral lymphoma were diagnosed at our institution. All patients had biopsy-proven disease, the pathology of which was reviewed for this study. Results: The overall median survival time was 24 months and one-, two- and three-year overall survival was 59, 46 and 29% respectively. The median radiation dose was 46 Gy, ranging from 19.5 to 60 Gy. The median dose per fraction was 2 Gy (ranging from 1.61 to 3 Gy). The median elapsed treatment time was 32 days (ranging from three to 45 days). We were not able to demonstrate any statistically significant difference between patients who received radiotherapy alone (n = 14, median survival time = 24 months) and those who received a combination of chemotherapy and radiotherapy (n = 11, median survival time = 30 months), (p = 0.4). Prognostic factors of survival were tested using a univariate analysis (Wilcoxon test). Parameters such as mass appearance (unilobular, p = 0.048), performance status at the time of the diagnosis (0 to 1, p = 0.014), and CT imaging (hypodense, p = 0.043) influenced positively survival. Centroblastic histology (Kiel) was found associated with a negative prognosis (p = 0.043). (orig./MG)

  15. Cerebritis: an unusual complication of Klebsiella pneumoniae.

    Science.gov (United States)

    Majumdar, Mainak; Simes, David C; Prabha, Ramesh D

    2009-01-01

    Cerebritis is part of a continuum of brain infection and is difficult to diagnose. Cerebritis caused by Klebsiella in immunocompetent adults without predisposing factors such as neurosurgery or penetrating brain injury has not been reported before. We report a case of Klebsiella cerebritis in an adult patient with a proven extracranial focus of infection. We suggest considering cerebritis as a differential diagnosis for altered level of consciousness in patients of severe sepsis, even if an extracranial source of infection is proven. PMID:19881180

  16. Cerebritis: An unusual complication of Klebsiella pneumoniae

    OpenAIRE

    Majumdar, Mainak; Simes1, David C.; Prabha1, Ramesh D.

    2009-01-01

    Cerebritis is part of a continuum of brain infection and is difficult to diagnose. Cerebritis caused by Klebsiella in immunocompetent adults without predisposing factors such as neurosurgery or penetrating brain injury has not been reported before. We report a case of Klebsiella cerebritis in an adult patient with a proven extracranial focus of infection. We suggest considering cerebritis as a differential diagnosis for altered level of consciousness in patients of severe sepsis, even if an e...

  17. Cerebritis: An unusual complication of Klebsiella pneumoniae

    Science.gov (United States)

    Majumdar, Mainak; Simes1, David C.; Prabha1, Ramesh D.

    2009-01-01

    Cerebritis is part of a continuum of brain infection and is difficult to diagnose. Cerebritis caused by Klebsiella in immunocompetent adults without predisposing factors such as neurosurgery or penetrating brain injury has not been reported before. We report a case of Klebsiella cerebritis in an adult patient with a proven extracranial focus of infection. We suggest considering cerebritis as a differential diagnosis for altered level of consciousness in patients of severe sepsis, even if an extracranial source of infection is proven. PMID:19881180

  18. Cerebral edema associated with acute hepatic failure.

    OpenAIRE

    Fujiwara, Masachika; Watanabe,Akiharu; Yamauchi,Yasuhiko; Hashimoto, Makoto; Nakatsukasa, Harushige; Kobayashi, Michio; Higashi,Toshihiro; Nagashima,Hideo

    1985-01-01

    The clinicopathological findings of cerebral edema were investigated in patients with acute hepatic failure autopsied at Okayama University Hospital between 1970 and 1980 retrospectively. Nine (64%) of 14 hepatic failure cases were found to have cerebral edema during a post-mortem examination of the brain. Clinical features of the patients with cerebral edema were not significantly different from those of the patients without cerebral edema. However, general convulsions were observed more fre...

  19. Cerebral venous thrombosis in childhood

    Energy Technology Data Exchange (ETDEWEB)

    Huisman, T.A.G.M.; Martin, E.; Willi, U.V. [Dept. of Diagnostic Imaging and Radiology, University Children' s Hospital Zurich (Switzerland); Holzmann, D. [Dept. of Otorhinolaryngology, University Children' s Hospital Zurich, Zurich (Switzerland)

    2001-09-01

    This was a retrospective study to determine different etiologies of cerebral venous thrombosis (CVT) in childhood and to correlate extent and location of thrombosis with the etiology and the age of the child as well as the final outcome. In addition, the radiologic approach is discussed. This was a retrospective analysis of 19 children with CVT. The children were examined by contrast-enhanced dynamic CT. Radiologic findings were correlated with the etiology of CVT. Cerebral venous thrombosis is not as infrequent in children as has been thought. Cerebral venous thrombosis in children can occur due to trauma (n=9), infections (n=7), or coagulation disorders (n=3). Extent and location of thrombosis, as well as complications, final outcome, and therapy, depend on the etiology. Computed tomography remains a valuable primary imaging modality in the diagnosis of CVT in the acutely injured or diseased child. (orig.)

  20. Cerebral venous thrombosis in childhood

    International Nuclear Information System (INIS)

    This was a retrospective study to determine different etiologies of cerebral venous thrombosis (CVT) in childhood and to correlate extent and location of thrombosis with the etiology and the age of the child as well as the final outcome. In addition, the radiologic approach is discussed. This was a retrospective analysis of 19 children with CVT. The children were examined by contrast-enhanced dynamic CT. Radiologic findings were correlated with the etiology of CVT. Cerebral venous thrombosis is not as infrequent in children as has been thought. Cerebral venous thrombosis in children can occur due to trauma (n=9), infections (n=7), or coagulation disorders (n=3). Extent and location of thrombosis, as well as complications, final outcome, and therapy, depend on the etiology. Computed tomography remains a valuable primary imaging modality in the diagnosis of CVT in the acutely injured or diseased child. (orig.)

  1. Neuronal autophagy in cerebral ischemia

    Institute of Scientific and Technical Information of China (English)

    Feng Xu; Jin-Hua Gu; Zheng-Hong Qin

    2012-01-01

    Autophagy has evolved as a conserved process for the bulk degradation and recycling of cytosolic components,such as long-lived proteins and organelles.In neurons,autophagy is important for homeostasis and protein quality control and is maintained at relatively low levels under normal conditions,while it is upregulated in response to pathophysiological conditions,such as cerebral ischemic injury.However,the role of autophagy is more complex.It depends on age or brain maturity,region,severity of insult,and the stage of ischemia.Whether autophagy plays a beneficial or a detrimental role in cerebral ischemia depends on various pathological conditions.In this review,we elucidate the role of neuronal autophagy in cerebral ischemia.

  2. Cerebral state index during propofol anesthesia

    NARCIS (Netherlands)

    Jensen, EW; Litvan, H; Revuelta, M; Rodriguez, BE; Caminal, P; Martinez, P; Vereecke, H; Struys, MMRF

    2006-01-01

    Background: The objective of this study was to prospectively test the Cerebral State Index designed for measuring the depth of anesthesia. The Cerebral State Index is calculated using a fuzzy logic combination of four subparameters of the electroencephalographic signal. The performance of the Cerebr

  3. Cerebral toksoplasmose primaert diagnosticeret som tumor

    DEFF Research Database (Denmark)

    Cortsen, M E; Skøt, J; Skriver, E B

    1992-01-01

    Three cases of cerebral toxoplasmosis as the presenting manifestation of AIDS are reported. The initial diagnoses were brain tumors because of the cerebral mass lesions which resembled glioblastoma. In the light of the increasing occurrence of AIDS, attention is drawn to cerebral toxoplasmosis...

  4. Neuroevolutional Approach to Cerebral Palsy and Speech.

    Science.gov (United States)

    Mysak, Edward D.

    Intended for cerebral palsy specialists, the book emphasizes the contribution that a neuroevolutional approach to therapy can make to habilitation goals of the child with cerebral palsy and applies the basic principles of the Bobath approach to therapy. The first section discusses cerebral palsy as a reflection of disturbed neuro-ontogenisis and…

  5. Cerebral vasculitis associated with cocaine abuse

    International Nuclear Information System (INIS)

    A case of cerebral vasculitis in a previously healthy 22-year-old man with a history of cocaine abuse is described. Cerebral angiograms showed evidence of vasculitis. A search for possible causes other than cocaine produced no results. The authors include cocaine with methamphetamines, heroin, and ephedrine as illicit drugs that can cause cerebral vasculitis

  6. [Relationship between executive functioning and behaviour in children with cerebral palsy].

    Science.gov (United States)

    Muriel, V; Garcia-Molina, A; Aparicio-Lopez, C; Ensenat, A; Roig-Rovira, T

    2015-10-16

    Introduccion. La paralisis cerebral se define como un grupo de trastornos del desarrollo del movimiento y la postura que cursa con deficits cognitivos, alteraciones emocionales, de conducta y sociales. Objetivo. Estudiar la relacion entre el funcionamiento ejecutivo y la conducta en niños con paralisis cerebral a partir de las respuestas aportadas por padres y profesores en el Behavior Rating Inventory of Executive Function (BRIEF) y el sistema de evaluacion de la conducta adaptativa (ABAS-II). Pacientes y metodos. La muestra quedo formada por 46 niños con paralisis cerebral, con una edad media de 10,26 ± 2,95 años. Del total, 44 niños se distribuyeron en el Gross Motor Function Classification System (GMFCS) en nivel I (n = 16), nivel II (n = 3), nivel III (n = 11), nivel IV (n = 10) y nivel V (n = 4). Resultados. Los resultados mostraron relacion entre el BRIEF y el ABAS-II; ademas, se obtuvieron discrepancias entre las respuestas aportadas por padres y profesores, tanto en el ABAS-II como en el BRIEF. Asimismo, se hallo relacion entre el GMFCS y los subindices de vida en el hogar, indice practico y autocuidado del ABAS-II. Conclusiones. Se encontro relacion entre el funcionamiento ejecutivo y la conducta adaptativa en niños con paralisis cerebral. Se hallaron discrepancias en las respuestas aportadas por padres y profesores. Por ultimo, los datos muestran que, a mayor afectacion motora, mayores dificultades en el hogar, en el indice practico y en el autocuidado.

  7. Features to validate cerebral toxoplasmosis

    Directory of Open Access Journals (Sweden)

    Carolina da Cunha Correia

    2013-06-01

    Full Text Available Introduction Neurotoxoplasmosis (NT sometimes manifests unusual characteristics. Methods We analyzed 85 patients with NT and AIDS according to clinical, cerebrospinal fluid, cranial magnetic resonance, and polymerase chain reaction (PCR characteristics. Results In 8.5%, focal neurological deficits were absent and 16.4% had single cerebral lesions. Increased sensitivity of PCR for Toxoplasma gondii DNA in the central nervous system was associated with pleocytosis and presence of >4 encephalic lesions. Conclusions Patients with NT may present without focal neurological deficit and NT may occur with presence of a single cerebral lesion. Greater numbers of lesions and greater cellularity in cerebrospinal fluid improve the sensitivity of PCR to T gondii.

  8. Lifetime costs of cerebral palsy

    DEFF Research Database (Denmark)

    Kruse, Marie; Michelsen, Susan Ishøy; Flachs, Esben Meulengracht;

    2009-01-01

    This study quantified the lifetime costs of cerebral palsy (CP) in a register-based setting. It was the first study outside the US to assess the lifetime costs of CP. The lifetime costs attributable to CP were divided into three categories: health care costs, productivity costs, and social costs....... The population analyzed was retrieved from the Danish Cerebral Palsy Register, which covers the eastern part of the country and has registered about half of the Danish population of individuals with CP since 1950. For this study we analyzed 2367 individuals with CP, who were born in 1930 to 2000 and were alive...

  9. Vortex Dynamics in Cerebral Aneurysms

    CERN Document Server

    Byrne, Greg

    2013-01-01

    We use an autonomous three-dimensional dynamical system to study embedded vortex structures that are observed to form in computational fluid dynamic simulations of patient-specific cerebral aneurysm geometries. These structures, described by a vortex which is enclosed within a larger vortex flowing in the opposite direction, are created and destroyed in phase space as fixed points undergo saddle-node bifurcations along vortex core lines. We illustrate how saddle-node bifurcations along vortex core lines also govern the formation and evolution of embedded vortices in cerebral aneurysms under variable inflow rates during the cardiac cycle.

  10. Sociedad por Acciones Simplificada

    Directory of Open Access Journals (Sweden)

    Carlos Andrés Arcila Salazar

    2009-06-01

    Full Text Available En Colombia, aspectos como la responsabilidad limitada; supresión de la llamada doctrina de ultra vires; duración ilimitada; eliminación de la regla, una acción, un voto; remedios al abuso de los derechos; posibilidad de eliminar prohibiciones a los administradores, libertad de establecer restricciones para la transferencia de acciones y la simplificación de los procedimientos de fusión; son inviables bajo nuestra legislación. Sin embargo, la Ley 1258 de 2008, ha incorporado al derecho societario colombiano un nuevo tipo societario híbrido, llamado “Sociedad por Acciones Simplificada”. Esta forma societaria híbrida se basa en un principio básico: garantizar amplia libertad a los empresarios en la estructuración de sus relaciones a través de disposiciones contractuales. La S.A.S. provee a los empresarios significativa flexibilidad contractual, a la vez que preserva beneficios como la limitación de la responsabilidad.

  11. Sociedad por Acciones Simplificada

    Directory of Open Access Journals (Sweden)

    Carlos Andrés Arcila Salazar

    2009-07-01

    Full Text Available En Colombia, aspectos como la responsabilidad limitada; supresión de la llamada doctrina de ultra vires; duración ilimitada; eliminación de la regla, una acción, un voto; remedios al abuso de los derechos; posibilidad de eliminar prohibiciones a los administradores, libertad de establecer restricciones para la transferencia de acciones y la simplificación de los procedimientos de fusión; son inviables bajo nuestra legislación. Sin embargo, la Ley 1258 de 2008, ha incorporado al derecho societario colombiano un nuevo tipo societario híbrido, llamado “Sociedad por Acciones Simplificada”. Esta forma societaria híbrida se basa en un principio básico: garantizar amplia libertad a los empresarios en la estructuración de sus relaciones a través de disposiciones contractuales. La S.A.S. provee a los empresarios significativa flexibilidad contractual, a la vez que preserva beneficios como la limitación de la responsabilidad.

  12. Tolerancia al daño inducido bajo solicitaciones de contacto cíclicas en carburos cementados WC-Co//Tolerance induced damage under cyclic contact loading of WC-Co cemented carbides

    Directory of Open Access Journals (Sweden)

    David Coureaux‐Mustelier

    2014-01-01

    Full Text Available El comportamiento mecánico de los carburos cementados WC-Co ha sido estudiado en detalle teniendo en cuenta los defectos preexistentes del material (daño intrínseco. Sin embargo, la información sobre los efectos del daño inducido en servicio (daño extrínseco en la integridad estructural de estos materiales esescasa. En este contexto, en este trabajo se evalúa la influencia del daño extrínseco en la resistencia mecánica residual de dos calidades con microestructuras diferentes. Para ello, se emplea la técnica de indentación esférica como medio para generar daño de forma controlada. Los resultados muestran que al incrementar el tamaño de grano del carburo y el contenido de cobalto, la respuesta mecánica de carburos cementados frente al contacto esférico es cada vez más cuasi-plástica, bajo la aplicación de cargas tanto monotónicas como cíclicas, y en consecuencia el material muestra una mayor tolerancia al daño.Palabras claves: carburos cementados, indentación esférica, resistencia mecánica residual, tolerancia al daño._______________________________________________________________________________AbstractThe mechanical behavior of WC-Co cemented carbides has been studied in detail taking into account the pre-existing material (intrinsic damage defects. However, information on the effects of service-induced damage (extrinsic damage on the structural integrity of these materials is limited. In this context, in thispaper the influence of extrinsic damage on the residual strength of two grades with different microstructures is evaluated. With this purpose, a spherical indentation technique is employed as a means for generating a controlled damage. The results show that by increasing the grain size of the carbide and the cobalt content, the mechanical properties of cemented carbides compared to spherical contact isincreasingly quasi-plastic, under the application of both monotonic and cyclic loads, and consequently the

  13. Contraceptives and cerebral thrombosis: a five-year national case-control study

    DEFF Research Database (Denmark)

    Lidegaard, Øjvind; Kreiner, Svend

    2002-01-01

    Oral contraceptives; Cerebral thrombosis; Thrombotic stroke; Transitory cerebral ischemic attack; Thrombosis......Oral contraceptives; Cerebral thrombosis; Thrombotic stroke; Transitory cerebral ischemic attack; Thrombosis...

  14. Caffeine induced changes in cerebral circulation

    International Nuclear Information System (INIS)

    While the caffeine induced cerebral vasoconstriction is well documented, the effects of oral ingestion of the drug in a dose range comparable to the quantities in which it is usually consumed and the intensity and duration of the associated reduction in cerebral circulation are unknown. Cerebral blood flow was measured via the 133Xenon inhalation technique before and thirty and ninety minutes after the oral administration of 250 mg of caffeine or a placebo, under double-blind conditions. Caffeine ingestion was found to be associated with significant reductions in cerebral perfusion thirty and ninety minutes later. The placebo group showed no differences between the three sets of cerebral blood flow values

  15. [Should cerebral autoregulation be reassessed?

    DEFF Research Database (Denmark)

    Secher, Niels H.

    2009-01-01

    Maintained cardiac output (CO) and cerebral oxygenation (ScO2) are of importance for a reduction in perioperative complications. Normovolaemia is defined as a central blood volume that does not limit CO for the supine patient and is maintained by individualized goal directed fluid therapy. Thereby...

  16. Investigating cerebral oedema using poroelasticity.

    Science.gov (United States)

    Vardakis, John C; Chou, Dean; Tully, Brett J; Hung, Chang C; Lee, Tsong H; Tsui, Po-Hsiang; Ventikos, Yiannis

    2016-01-01

    Cerebral oedema can be classified as the tangible swelling produced by expansion of the interstitial fluid volume. Hydrocephalus can be succinctly described as the abnormal accumulation of cerebrospinal fluid (CSF) within the brain which ultimately leads to oedema within specific sites of parenchymal tissue. Using hydrocephalus as a test bed, one is able to account for the necessary mechanisms involved in the interaction between oedema formation and cerebral fluid production, transport and drainage. The current state of knowledge about integrative cerebral dynamics and transport phenomena indicates that poroelastic theory may provide a suitable framework to better understand various diseases. In this work, Multiple-Network Poroelastic Theory (MPET) is used to develop a novel spatio-temporal model of fluid regulation and tissue displacement within the various scales of the cerebral environment. The model is applied through two formats, a one-dimensional finite difference - Computational Fluid Dynamics (CFD) coupling framework, as well as a two-dimensional Finite Element Method (FEM) formulation. These are used to investigate the role of endoscopic fourth ventriculostomy in alleviating oedema formation due to fourth ventricle outlet obstruction (1D coupled model) in addition to observing the capability of the FEM template in capturing important characteristics allied to oedema formation, like for instance in the periventricular region (2D model). PMID:26749338

  17. Embodying Investigations of Cerebral Palsy

    DEFF Research Database (Denmark)

    Martiny, Kristian Møller Moltke

    The main question of Kristian Martiny’s dissertation is: how do we help persons living with the brain damage, cerebral palsy (CP)? This question is as complex and difficult to answer as any healthcare question. Martiny argues that we need to ‘open up’ how we do ( cognitive ) science in order...

  18. MR imaging of cerebral palsy

    Energy Technology Data Exchange (ETDEWEB)

    Saginoya, Toshiyuki [Urasoe General Hospital, Okinawa (Japan); Yamaguchi, Keiichiro; Kuniyoshi, Kazuhide [and others

    1996-06-01

    We evaluated 35 patients with cerebral palsy on the basis of MR imaging findings in the brain. The types of palsy were spastic quadriplegia (n=11), spastic diplegia (n=9), spastic hemiplegia (n=2), double hemiplegia (n=1), athetosis (n=10) and mixed (n=2). Of all patients, 28 (80%) generated abnormal findings. In spastic quadriplegia, although eight cases revealed severe brain damage, two cases showed no abnormal findings in the brain. One of the three had cervical cord compression caused by atlanto-axial subluxation. In spastic diplegia, the findings were divided according to whether the patient was born at term or preterm. If the patient had been born prematurely, the findings showed periventricular leukomalacia and abnormally high intensity in the posterior limbs of the internal capsule on T2-weighted images. MR imaging in spastic hemiplegia revealed cerebral infarction. In the athetoid type, half of all cases showed either no abnormal findings or slight widening of the lateral ventricle. Three cases showed abnormal signals of the basal ganglia. The reason why athetoid-type palsy did not show severe abnormality is unknown. We believe that MR imaging is a useful diagnostic modality to detect damage in the brain in cerebral palsy and plays an important role in the differentiation of cerebral palsy from the spastic palsy disease. (author)

  19. Cerebral blood-flow tomography

    DEFF Research Database (Denmark)

    Lassen, N A; Henriksen, L; Holm, S;

    1983-01-01

    Tomographic maps of local cerebral blood flow (CBF) were obtained with xenon-133 and with isopropyl-amphetamine-iodine-123 (IMP) in 11 subjects: one normal, two tumor cases, and eight cerebrovascular cases. A highly sensitive four-face, rapidly rotating, single-photon emission tomograph was used...

  20. Cerebral imaging revealing Alzheimer's disease

    International Nuclear Information System (INIS)

    Cerebral imaging is the only non-invasive means of examining the brain and is essential in studying Alzheimer's disease. As a tool for early diagnosis, evaluation and treatment monitoring, this technology is at the heart of the research being done to further improve its reliability and sensitivity. (authors)

  1. MR imaging of cerebral palsy

    International Nuclear Information System (INIS)

    We evaluated 35 patients with cerebral palsy on the basis of MR imaging findings in the brain. The types of palsy were spastic quadriplegia (n=11), spastic diplegia (n=9), spastic hemiplegia (n=2), double hemiplegia (n=1), athetosis (n=10) and mixed (n=2). Of all patients, 28 (80%) generated abnormal findings. In spastic quadriplegia, although eight cases revealed severe brain damage, two cases showed no abnormal findings in the brain. One of the three had cervical cord compression caused by atlanto-axial subluxation. In spastic diplegia, the findings were divided according to whether the patient was born at term or preterm. If the patient had been born prematurely, the findings showed periventricular leukomalacia and abnormally high intensity in the posterior limbs of the internal capsule on T2-weighted images. MR imaging in spastic hemiplegia revealed cerebral infarction. In the athetoid type, half of all cases showed either no abnormal findings or slight widening of the lateral ventricle. Three cases showed abnormal signals of the basal ganglia. The reason why athetoid-type palsy did not show severe abnormality is unknown. We believe that MR imaging is a useful diagnostic modality to detect damage in the brain in cerebral palsy and plays an important role in the differentiation of cerebral palsy from the spastic palsy disease. (author)

  2. Cerebral edema in drug addicts

    Directory of Open Access Journals (Sweden)

    Daruši Dragana J.

    2014-01-01

    Full Text Available Background/Aim. The effect of drugs leaves permanent consequences on the brain, organic in type, followed by numerous manifestations, and it significantly affects the development of mental dysfunctions. The clinicians are often given a task to estimate a patient’s personality during treatment or during experts estimate of a drug addict. The aim of this research was to determine the differences, if any, in characteristics of addicts experience and personality traits in drug addicts with or without cerebral edema. Methods. The research was conducted on a sample of 252 male drug addicts, the average age of 23.3 (SD = 4.3 years. Cerebral edema was confirmed on magnetic resonance (MR images of the brain performed during the treatment of the addicts. The participants were tested by the psychologists using Minnesota Multiphasic Personality Inventory (MMPI-201 test, and the data were processed using canonical discriminate analysis within the SPSS program. The dependent variable in the study was cerebral edema. A block of independent variables, designed for the requirements of this study, consisted of two subgroups. The first one consisted of 12 variables describing the relevant characteristics of drug abuse. The second subgroup consisted of 8 psychopathological tendencies in the personality defined by the mentioned test. Results. Cerebral edema was confirmed in 52 (20.63% of the drug addicts. The differences between the groups of drug addicts with and without cerebral edema were determined in the following: the time span of taking drugs (0.301, use of alcohol parallel with drugs (0.466, and treatment for addiction (0.603. In the drug addicts with a cerebral edema, MMPI-201 confirmed the increase in the scales for hypochondria, psychopathic deviations and psychastenia, and the decrease in the scales for schizophrenia and depression. Conclusion. Our study confirmed a possible connection between cerebral edema and personality traits in a number of the

  3. Anestesia e paralisia cerebral Anestesia y parálisis cerebral Anesthesia and cerebral palsy

    Directory of Open Access Journals (Sweden)

    Március Vinícius M Maranhão

    2005-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A paralisia cerebral (PC é uma doença não progressiva decorrente de lesão no sistema nervoso central, levando a um comprometimento motor do paciente. O portador de PC freqüentemente é submetido a procedimentos cirúrgicos devido a doenças usuais e situações particulares decorrentes da paralisia cerebral. Foi objetivo deste artigo revisar aspectos da paralisia cerebral de interesse para o anestesiologista, permitindo um adequado manuseio pré, intra e pós-operatório neste tipo de paciente. CONTEÚDO: O artigo aborda aspectos da paralisia cerebral como etiologia, classificação, fatores de risco, fisiopatologia, quadro clínico, diagnóstico, terapêuticas utilizadas bem como avaliação pré-operatória, medicação pré-anestésica, manuseio intra e pós-operatório, analgesia pós-operatória e dor crônica. CONCLUSÕES: O anestesiologista desempenha um papel importante na diminuição da morbidade e mortalidade anestésico-cirúrgica em pacientes portadores de paralisia cerebral. O conhecimento da fisiopatologia dos diferentes tipos de paralisia cerebral bem como das doenças associadas e suas terapêuticas é imprescindível, pois permite ao anestesiologista antecipar e prevenir complicações intra e pós-operatórias neste tipo de paciente.JUSTIFICATIVA Y OBJETIVOS: La parálisis cerebral (PC es una enfermedad no progresiva consecuente de una lesión en el sistema nervioso central, llevando a un comprometimiento motor del paciente. El portador de PC, frecuentemente es sometido a procedimientos quirúrgicos debido a enfermedades usuales y situaciones particulares consecuentes de la parálisis cerebral. El objetivo de este artículo, fue revisar aspectos de la parálisis cerebral de interés para el anestesista, permitiendo un adecuado manoseo pre, intra y posoperatorio en este tipo de paciente. CONTENIDO: El artículo aborda aspectos de la parálisis cerebral como etiología, clasificación, factores de

  4. Aspectos sociodemográficos e reprodutivos do abortamento induzido de mulheres internadas em uma maternidade do Município da Serra, ES Aspectos socio demográficos y reproductivos del aborto inducido en mujeres internadas en una maternidad del municipio de Sierra, ES Socio demographic and reproductive aspects of the induced miscarriage of women hospitalized in a maternity hospital of serra, state of Espírito Santo

    Directory of Open Access Journals (Sweden)

    Priscilla Rocha Araujo Nader

    2008-12-01

    Full Text Available Objetivo: Comparar aspectos sociodemográficos e reprodutivos entre mulheres que induziram a interrupção da gestação e mulheres que levaram a gestação a termo, admitidas em uma maternidade pública. Métodos: Estudo caso-controle onde foram incluídas 21 mulheres que realizaram abortamento induzido e 83 que tiveram gestação a termo, no período de agosto de 2005 a janeiro de 2006. Resultados: Não houve diferença significativa na comparação entre as freqüências dos grupos em relação à idade, cor da pele, anos de estudo, religião, renda mensal, idade da menarca, idade da coitarca, idade da primeira gestação, número de gestações, intervalo entre a última e a penúltima gestação e o número de filhos vivos. O estado conjugal casada/em união estável [OR=0,241 (IC95% 0,061 0,951] e desejo pela gravidez [OR=0,168 (IC95% 0,042 0,669] mostraram-se associados à ocorrência de abortamento induzido como fatores de proteção. Conclusão: Para atenuar o problema do abortamento inseguro, deve-se investir na promoção da saúde reprodutiva incentivando o acesso à educação sexual e ao planejamento familiar.Objetivo: Comparar aspectos socio demográficos y reproductivos entre mujeres que indujeron la interrupción del embarazo y mujeres que concluyeron el embarazo y fueron admitidas en una maternidad pública. Métodos: Estudio caso-control donde fueron incluidas 21 mujeres que realizaron aborto inducido y 83 que tuvieron la gestión completa, en el período de agosto de 2005 a enero de 2006. Resultados: No hubo diferencia significativa en la comparación entre las frecuencias de los grupos en relación a la edad, color de piel, años de estudio, religión, renta mensual, edad de menopausia, edad de iniciación sexual, edad del primer embarazo, número de embarazos, intervalo entre el último y el penúltimo embarazo y el número de hijos vivos. El estado conyugal casado/a estable [OR=0,241 (IC95% 0,061 0,951] y deseo por el

  5. Entrenamiento del equilibrio en los niños y niñas con parálisis cerebral espástica y sus efectos.

    OpenAIRE

    Ruiz García, Andrea

    2015-01-01

    Introducción: la parálisis cerebral (PC) es un trastorno permanente, pero no invariable, de la postura y del movimiento que resulta de un trastorno cerebral no progresivo debido a factores hereditarios o eventos que ocurren durante el embarazo, el parto, el período neonatal o en los primeros días de vida, lo que limita la actividad motora acompañado a menudo por trastornos sensoriales, cognitivos, de la comunicación, de la percepción y trastornos del comportamiento. La parálisis cerebral de t...

  6. CHIRAL UNIVERSES AND QUANTUM EFFECTS PRODUCED BY ELECTROMAGNETIC FIELDS UNIVERSOS QUIRALES Y EFECTOS CUÁNTICOS PRODUCIDOS POR CAMPOS ELECTROMAGNÉTICOS

    Directory of Open Access Journals (Sweden)

    Héctor Torres-Silva

    2008-11-01

    Full Text Available The accepted structure of space and vacuum derives from the results of relativistic cosmology and quantum field theory. It is demonstrated that a chiral interface between enantiomeric regions of a closed universe, or a (right R-Universe and (left L-Universe, related by an element of PCT symmetry along the interface, represents a construct with all the attributes required of the theoretical vacuum, in-so-far as quantum behaviour is then seen to be induced by the vacuum interface. Quantum mechanics emerges as a special case of classical mechanics, rather than the latter being a subset of the former. This removes the quantum-mechanical observational problem, explains the cosmological large-number coincidences, and accounts for the anti-matter in the cosmos.La estructura aceptada del espacio y el vacío se derivan de los resultados de la cosmología relativística y de la teoría cuántica de campo. Se demuestra que una interfaz quiral entre regiones enantioméricas de un universo cerrado, o un universo derecho y un universo izquierdo, relacionados por un elemento de simetría PCT a lo largo de la interfaz, representa un modelo con todos los atributos requeridos por el vacío teórico. Se desprende que el comportamiento cuántico es entonces visto que es inducido por la interfaz de vacío. La mecánica quántica emerge como un caso especial de la mecánica clásica, más bien que siendo la última un subconjunto de la primera. Esto resuelve el problema observacional mecánico cuántico, explica las coincidencias de los grandes números cosmológicos y toma en cuenta la antimateria en el cosmos.

  7. La trapia endovascular: una nueva alternativa en el tratamiento del vasoespasmo cerebral asociado a la hemorragia subaracnoidea espontánea Endovascular therapy: new alternative for treatment of cerebral vasospasm associated with spontaneous subarachnoid hemorrhage

    Directory of Open Access Journals (Sweden)

    Sergio Vargas

    1998-04-01

    Full Text Available EI vaso espasmo cerebral es la principal causa tratable de muerte e incapacidad por hemorragia subaracnoidea espontánea secundaria a la ruptura de un aneurisma cerebral. Sin embargo, su tratamiento ha sido tradicionalmente frustrante, con resultados desalentadores. A pesar de que aún no se han aclarado del todo los mecanismos fisiopatológicos a través de los cuales ocurre este intrigante fenómeno, en los últimos 9 años, paralelamente al desarrollo de las técnicas endovasculares para el tratamiento de las enferm~dades cerebrovasculares, han surgido nuevas alternativas en el manejo del vasoespasmo cerebral. Entre ellas se destacan el uso intraarterial de papaverina y la angioplastia con balón de los vasos cerebrales. Se presenta una revisión del estado actual de estos novedosos instrumentos terapéuticos, así como el reporte de un caso en el cual usamos la papaverina intraarterial en el tratamiento del vasoespasmo quese presentó durante un procedimiento endovascular para excluir un aneurisma de la arteria cerebral media. Cerebral vasospasm is the first treatable cause of death and disability secondary to spontaneous subarachnoid hemorrhage due to ruptured cerebral aneurysms. However, its treatment has been disapointing with poor results. Despite the fact that the physiopathologic mechanisms governing this phenomenon are largely unknown, during the last nine years, simultaneously with the development of endovascular therapy techniques for treatment of cerebrovascular diseases, two new alternatives have emerged in order to alleviate cerebral vasospasm: intraarterial papaverine and cerebral balloon angioplasty. We report the use of intraarterial papaverine in one case to treat cerebral vasospasm presented during the endovascular therapy procedure; a review of literature is included.

  8. Por que sou rondoniano

    Directory of Open Access Journals (Sweden)

    Mércio Pereira Gomes

    2009-01-01

    Full Text Available Numa revisão contextualizada no tempo e projetada pelos seus resultados, a obra do sertanista marechal Cândido Rondon (1867-1958 é avaliada positivamente pela dedicação à causa dos povos indígenas do Brasil, pela formação de uma ética de respeito do brasileiro para com os índios e pela institucionalização do dever do Estado brasileiro de proteger, assistir e ajudar os povos indígenas a manterem-se coesos e autônomos e ao mesmo tempo se projetarem no mundo mais amplo. A vida de Rondon é acompanhada desde a sua formação como cadete da Escola Militar, como membro da Igreja do Apostolado Positivista, como comandante da Expedição Rondon (1907-1930, que levou o telégrafo de Cuiabá a Porto Velho, e especialmente como criador e dirigente-mor do Serviço de Proteção aos Índios (SPI, 1910-1967. Rondon é o criador da expressão "Morrer se preciso for, matar nunca", que pautou a ação de indigenistas brasileiros que fizeram os primeiros contatos com muitos povos indígenas desde 1910. E muitos morreram seguindo essa norma, numa clara demonstração do novo espírito humanista criado pela atitude rondoniana. O indigenismo brasileiro implantado por Rondon teve altos e baixos ao longo de quase cem anos, que hoje prossegue pela Fundação Nacional do Índio (Funai. De fato, muitos povos indígenas perderam suas terras e muitos foram dizimados no século XX, mas os mais de 220 que sobreviveram vêm crescendo em número, obtendo suas terras (13% do território nacional e conquistando novos espaços político-culturais no Brasil.This paper reviews the life and work of Brazilian Indianist Marshall Cândido Rondon. Rondon's life is marked by a profound dedication to the Brazilian Indian cause and to instilling in Brazilians a respect for Indian peoples. He influenced the Brazilian government in shaping a policy of protecting, assisting, and helping Indian peoples retain cohesive, self-determined societies. He also encouraged Indians to

  9. Cerebral aterial spasm. I. Adrenergic mechanism in experimental cerebral vasospasm.

    Directory of Open Access Journals (Sweden)

    Morooka,Hiroshi

    1978-04-01

    Full Text Available This study demonstrates that an adrenergic mechanism plays an important role in producing the delayed cerebral vasospasm which follows subarachnoid hemorrhage. Results were as follows: 1. Experimental subarachnoid hemorrhage (SAH was produced by injection of fresh arterial blood into the cisterna magna in cats. The cerebral vasospasm was shown angiographically to be biphasic in nature: immediate constriction lasting 1 h and marked prolonged spasm occurring between the 3rd and 5th day after SAH. The amount of noradrenaline (NA and dopamine-beta-hydroxylase (DBH activity decreased over a period of 24 h both within the wall of the basilar artery and in the locus ceruleus and then gradually increased, reaching a maximum on the 3rd day after SAH. 2. Topical application of spasmogenic substances (NA and blood produced a marked constriction of the hypersensitive basilar artery on the 3rd day after SAH. 3. 6-Hydroxydopamine (6-OHDA injection into the cisterna magna produced prolonged vasocilatation. The dilated vessel responded with mild transient constriction after the topical application of NA or fresh blood. DBH activity and NA concentration in the vessels, locus ceruleus and medial hypothalamus decreased markedly on the 3rd day after the cisternal injection of 6-OHDA. 4. Various spasmogenic substances (i.e. serotonin, NA, prostaglandins and methemoglobin were measured in a mixture of equal volume of CSF and blood in cats. ONly the serotonin in the mixed fluid produced vasoconstriction. Spasmogenic substances decreased markedly in the mixed fluid incubated for 3 days at 37 degrees C, and none of these substances apart from methemoglobin was present in a concentration sufficient to produce constriction of vessels. 5. These results suggest that early spasm is induced by serotonin around the arteries of the cranial base, and delayed spasm might be caused by hyperreaction of cerebral vessels to spasmogenic substances such as methemoglobin, during the

  10. [Cerebral artery infarction presented as an unusual complication of acute middle otitis].

    Science.gov (United States)

    Moscote-Salazar, Luis Rafael; Alcalá-Cerra, Gabriel; Castellar-Leones, Sandra Milena; Gutiérrez-Paternina, Juan José

    2013-01-01

    Introducción: la otitis media aguda es una inflamación del oído medio frecuente en la edad pediátrica. Aproximadamente 2 % de todos los casos desarrolla complicaciones intracraneales, más específicamente meningitis; por lo general, los infartos cerebrales originados por esta última son venosos. Rara vez se ha descrito la ocurrencia de un infarto arterial cerebral como complicación directa de la otitis media aguda. Caso clínico: niña de 12 meses de edad quien fue llevada a un servicio de urgencias por síndrome febril secundario a otitis media aguda y alteración del estado de conciencia. A la exploración física se identificó que estaba somnolienta, con anisocoria, midriasis en el ojo derecho y hemiparesia izquierda. Con la tomografía axial computarizada de cerebro se apreció un infarto arterial cerebral extenso. Los padres no autorizaron la craniectomía descompresiva y la paciente falleció a las 48 horas de su ingreso hospitalario. Conclusiones: a pesar de los recursos tecnológicos con los que se dispone actualmente, el infarto cerebral relacionado con la otitis media aguda tiene una evolución tórpida. Los signos neurológicos focalizadores y el deterioro progresivo deben apuntar a la ineficacia del tratamiento antimicrobiano instaurado.

  11. Chinese semantic processing cerebral areas

    Institute of Scientific and Technical Information of China (English)

    SHAN Baoci; ZHANG Wutian; MA Lin; LI Dejun; CAO Bingli; TANG Yiyuan; WU Yigen; TANG Xiaowei

    2003-01-01

    This study has identified the active cerebral areas of normal Chinese that are associated with Chinese semantic processing using functional brain imaging. According to the traditional cognitive theory, semantic processing is not particularly associated with or affected by input modality. The functional brain imaging experiments were conducted to identify the common active areas of two modalities when subjects perform Chinese semantic tasks through reading and listening respectively. The result has shown that the common active areas include left inferior frontal gyrus (BA 44/45), left posterior inferior temporal gyrus (BA37); the joint area of inferior parietal lobules (BA40) and superior temporal gyrus, the ventral occipital areas and cerebella of both hemispheres. It gives important clue to further discerning the roles of different cerebral areas in Chinese semantic processing.

  12. Animal models of cerebral ischemia

    Science.gov (United States)

    Khodanovich, M. Yu.; Kisel, A. A.

    2015-11-01

    Cerebral ischemia remains one of the most frequent causes of death and disability worldwide. Animal models are necessary to understand complex molecular mechanisms of brain damage as well as for the development of new therapies for stroke. This review considers a certain range of animal models of cerebral ischemia, including several types of focal and global ischemia. Since animal models vary in specificity for the human disease which they reproduce, the complexity of surgery, infarct size, reliability of reproduction for statistical analysis, and adequate models need to be chosen according to the aim of a study. The reproduction of a particular animal model needs to be evaluated using appropriate tools, including the behavioral assessment of injury and non-invasive and post-mortem control of brain damage. These problems also have been summarized in the review.

  13. Cerebral calcifications and schizophreniform disorder

    Directory of Open Access Journals (Sweden)

    Leonardo Fernandez Meyer

    2013-01-01

    Full Text Available OBJECTIVES: Discuss pathophysiological aspects of cerebral calcifications (CC and highlight its importance related to the occurrence of neuropsychiatric syndromes. METHOD: Single case report. RESULT: Man 52 years old, 20 years after going through a total thyroidectomy, starts showing behavioral disturbance (psychotic syndrome. He was diagnosed as schizophrenic (paranoid subtype and submitted to outpatient psychiatric treatment. During a psychiatric admission to evaluate his progressive cognitive and motor deterioration, we identified a dementia syndrome and extensive cerebral calcifications, derived from iatrogenic hypoparathyroidism. CONCLUSION: The calcium and phosphorus disturbances, including hypoparathyroidism, are common causes of CC. Its symptoms can imitate psychiatric disorders and produce serious and permanent cognitive sequelae. The exclusion of organicity is mandatory in any psychiatric investigative diagnosis in order to avoid unfavorable outcomes, such as in the present case report.

  14. Cerebral Palsy: A Dental Update

    OpenAIRE

    Sehrawat, Nidhi; Marwaha, Mohita; Bansal, Kalpana; Chopra, Radhika

    2014-01-01

    ABSTRACT Special and medically compromised patients present a unique population that challenges the dentist’s skill and knowledge. Providing oral care to people with cerebral palsy (CP) requires adaptation of the skills we use everyday. In fact, most people with mild or moderate forms of CP can be treated successfully in the general practice setting. This article is to review various dental considerations and management of a CP patient. How to cite this article: Sehrawat N, Marwaha M, Bansal ...

  15. Baclofen in Spastic Cerebral Palsy

    OpenAIRE

    J Akhundian

    2002-01-01

    To evaluate the effect of oral baclofen in spastic cerebral palsy (cp), we studied 40 children with different clinical types of spastic cp. Half of these children served as control group and the others received oral baclofen. All of them were treated with physiotherapy under equal conditions for 6 weeks. We used two methods, modified Ashworth scale and range of motion for evaluation. At the end of therapy we found a significant improvement in the baclofen group compared to control group. As a...

  16. Cerebral palsy in preterm infants

    OpenAIRE

    Demeši-Drljan Čila; Mikov Aleksandra; Filipović Karmela; Tomašević-Todorović Snežana; Knežević Aleksandar; Krasnik Rastislava

    2016-01-01

    Background/Aim. Cerebral palsy (CP) is one of the leading causes of neurological impairment in childhood. Preterm birth is a significant risk factor in the occurrence of CP. Clinical outcomes may include impairment of gross motor function and intellectual abilities, visual impairment and epilepsy. The aim of this study was to examine the relationships among gestational age, type of CP, functional ability and associated conditions. Methods. The sample size w...

  17. Hydrocephalus in cerebral venous thrombosis.

    Science.gov (United States)

    Zuurbier, Susanna M; van den Berg, René; Troost, Dirk; Majoie, Charles B; Stam, Jan; Coutinho, Jonathan M

    2015-01-01

    Increased intracranial pressure is common in cerebral venous thrombosis (CVT), but hydrocephalus is rarely reported in these patients. We examined the frequency, pathophysiology and associated clinical manifestations of hydrocephalus in patients with CVT admitted to our hospital between 2000 and 2010 (prospectively since July 2006). Hydrocephalus was defined as a bicaudate index larger than the 95th percentile for age, and/or a radial width of the temporal horn of ≥ 5 mm. We excluded patients in whom hydrocephalus was caused by a disease other than CVT or if it was iatrogenic. 20 out of 99 patients with CVT had hydrocephalus. 6 patients with hydrocephalus were excluded from the analysis. Patients with hydrocephalus more often had focal neurological deficits (86 vs. 49%, p = 0.02) and were more frequently comatose (43 vs. 16%, p = 0.06), as compared to patients without hydrocephalus. Deep cerebral venous thrombosis (64 vs. 9%, p hydrocephalus. Intraventricular hemorrhage was present in 1 patient with hydrocephalus, compared to none among patients without hydrocephalus (7 vs. 0%, p = 0.15). Outcome at follow-up was worse in patients with hydrocephalus (mRS 0-1, 36 vs. 68%, p = 0.02; mortality 29 vs. 9%, p = 0.07). Hydrocephalus occurs more frequently in cerebral venous thrombosis than previously believed, especially in patients with deep cerebral venous thrombosis and edema of the basal ganglia. The presence of hydrocephalus is associated with a worse clinical outcome, but a direct causal relation is unlikely. Routine shunting procedures are not advisable.

  18. Apraxia in deep cerebral lesions.

    OpenAIRE

    Agostoni, E; Coletti, A.; G. Orlando; Tredici, G

    1983-01-01

    In a series of 50 patients with cerebrovascular lesions (demonstrated with CT scan), seven patients had lesions located in the basal ganglia and/or thalamus. All these seven patients were apractic. Ideomotor apraxia was present in all patients; five also had constructional apraxia, and one had bucco-facial apraxia. None of the patients had utilisation apraxia. These observations indicated that apraxia is not only a "high cerebral (cortical) function", but may depend also on the integrity of s...

  19. Clinical studies on cerebral infarction

    International Nuclear Information System (INIS)

    Hemorrhagic infarction (HI) is termed as the infarction in which a large part of the necrotic tissue is stippled with small hemorrhage. The pathogenetic mechanism of this disease still remains controversial. Cerebral infarction has long been divided into two subtypes-thrombosis and embolism-according to the pathogenetic mechanisms. Clinical studies were carried out in 31 cases of HI with cerebral thrombosis. CT findings of these cases were classified into five groups according to both size of low density area which indicates regions of infarction and distribution of arterial supply. The low density area of Type I-Type III were observed in the area of the middle cerebral artery. That of Type IV was observed in the area of the internal capsule and basal ganglia. That of Type V was observed in the area of the posterior cerebral artery. CT reveals two patterns of HI -pattern A and pattern B-. The CT finding of pattern A is appearance of high density area in the low density area. The CT finding of pattern B is appearance of iso density area in the low density area. rCBF was measured by 133Xe inhalation technique in 21 patients with CT type I, II and III. Thereafter, with regard to the various findings in CT, the clinical findings and CBF findings, a comparative study was carried out on these ten groups. From the results of present studies, it is concluded that sequential changes of CBF in cases with pattern A are different from those with pattern B, and that CBF measurement does not permit an estimation of a patient's chance for functionary recovery after a stroke in acute and subacute stage but permits estimation of functional outcome in chronic stage. (J.P.N.)

  20. MRI in cerebral toxocaral disease.

    OpenAIRE

    Rüttinger, P; Hadidi, H

    1991-01-01

    Toxocara canis, the common roundworm in the dog, can cause "visceral larva migrans" syndrome in humans, which may include generalised illness, eosinophilia, and symptoms arising from larval invasion of different organs. Of these, the clinically most important are liver, lungs, eyes and CNS. Involvement of the different parts of the CNS in human toxocaral disease has been described, but not the CT or MRI appearances of the cerebral lesions. In one case with a single focal epileptic fit, CT was...

  1. Late cerebral ischaemia after subarachnoid haemorrhage

    DEFF Research Database (Denmark)

    Edvinsson, L; Povlsen, G K

    2011-01-01

    Late cerebral ischaemia after subarachnoid haemorrhage (SAH) carries high morbidity and mortality because of reduced cerebral blood flow (CBF) and subsequent cerebral ischaemia. This is associated with upregulation of contractile receptors in cerebral artery smooth muscles via the activation...... of intracellular signalling. In addition, delayed cerebral ischaemia after SAH is associated with inflammation and disruption of the blood-brain barrier (BBB). This article reviews recent evidence concerning the roles of vasoconstrictor receptor upregulation, inflammation and BBB breakdown in delayed cerebral...... their sensitivity to endogenous agonists such as ET-1 and 5-HT by increasing their smooth muscle expression of receptors for these after SAH. This is associated with reduced CBF and neurological deficits. A number of signal transduction components mediating this receptor upregulation have been identified, including...

  2. Acute hypoxia increases the cerebral metabolic rate

    DEFF Research Database (Denmark)

    Vestergaard, Mark Bitsch; Lindberg, Ulrich; Aachmann-Andersen, Niels Jacob;

    2016-01-01

    imaging techniques were used to measure global cerebral blood flow and the venous oxygen saturation in the sagittal sinus. Global cerebral metabolic rate of oxygen was quantified from cerebral blood flow and arteriovenous oxygen saturation difference. Concentrations of lactate, glutamate, N......-acetylaspartate, creatine and phosphocreatine were measured in the visual cortex by magnetic resonance spectroscopy. Twenty-three young healthy males were scanned for 60 min during normoxia, followed by 40 min of breathing hypoxic air. Inhalation of hypoxic air resulted in an increase in cerebral blood flow of 15.5% (p = 0.......058), and an increase in cerebral metabolic rate of oxygen of 8.5% (p = 0.035). Cerebral lactate concentration increased by 180.3% ([Formula: see text]), glutamate increased by 4.7% ([Formula: see text]) and creatine and phosphocreatine decreased by 15.2% (p[Formula: see text]). The N-acetylaspartate concentration...

  3. Porøse materialer

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place

    2000-01-01

    Dette undervisningsnotat er en samling af noter, der refererer til den indledende del af kurset Materialmekanik og Porøse materailer på Insitut for Bærende Konstruktiner og Materialer (BKM).......Dette undervisningsnotat er en samling af noter, der refererer til den indledende del af kurset Materialmekanik og Porøse materailer på Insitut for Bærende Konstruktiner og Materialer (BKM)....

  4. MR findings of cerebral palsy

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Sang Hum; Chang, Seung Kuk; Cho, Mee Young; Park, Dong Woo; Kim, Jong Deok; Eun, Choong Ki [Pusan Paik Hospital, Pusan (Korea, Republic of)

    1994-11-15

    To evaluate the MR findings of brain damage in cerebral palised patients and to correlate it with gestational age and the time of damage. A retrospective analysis was performed in 40 patients who underwent MR scanning for evaluation of brain lesion in clinically diagnosed cerebral palsy. Authors classified the patients into two groups as premature and full-term and compared MR findings of the two groups. Abnormal MR findings were noted in 28 cases (70%). Five out of 6 patients who had been born prematurely showed isolate periventricular white matter lesions. Twenty-three out of 34 patients who had been born at full-term showed abnormal MR findings. Of these 23 patients, migration anomalies in 7 patients, isolate periventricular white matter lesions in 3 patients, and other combined periventricular subcortical white matter and deep gray matter lesions in 14 patients were seen. At least, 10 patients(43%) of full term group showed abnormal MRI findings reflecting intrauterine brain damage and all 5 patients of premature group showed isolate periventricular white matter lesions suggesting immaturity of brain. MRI is thought to be very useful in the assessment of brain damage for the patients with cerebral palsy by recognizing the location of the lesion and estimating the time of damage.

  5. MR findings of cerebral palsy

    International Nuclear Information System (INIS)

    To evaluate the MR findings of brain damage in cerebral palised patients and to correlate it with gestational age and the time of damage. A retrospective analysis was performed in 40 patients who underwent MR scanning for evaluation of brain lesion in clinically diagnosed cerebral palsy. Authors classified the patients into two groups as premature and full-term and compared MR findings of the two groups. Abnormal MR findings were noted in 28 cases (70%). Five out of 6 patients who had been born prematurely showed isolate periventricular white matter lesions. Twenty-three out of 34 patients who had been born at full-term showed abnormal MR findings. Of these 23 patients, migration anomalies in 7 patients, isolate periventricular white matter lesions in 3 patients, and other combined periventricular subcortical white matter and deep gray matter lesions in 14 patients were seen. At least, 10 patients(43%) of full term group showed abnormal MRI findings reflecting intrauterine brain damage and all 5 patients of premature group showed isolate periventricular white matter lesions suggesting immaturity of brain. MRI is thought to be very useful in the assessment of brain damage for the patients with cerebral palsy by recognizing the location of the lesion and estimating the time of damage

  6. Assessment of the hand in cerebral palsy

    OpenAIRE

    Praveen Bhardwaj; S Raja Sabapathy

    2011-01-01

    Cerebral palsy is the musculoskeletal manifestation of a nonprogressive central nervous system lesion that usually occurs due to a perinatal insult to the brain. Though the cerebral insult is static the musculoskeletal pathology is progressive. Some patients with cerebral palsy whose hands are affected can be made better by surgery. The surgical procedures as such are not very technically demanding but the assessment, decision-making, and selecting the procedures for the given patient make th...

  7. Cerebral energy metabolism during induced mitochondrial dysfunction

    DEFF Research Database (Denmark)

    Nielsen, T H; Bindslev, TT; Pedersen, S M;

    2013-01-01

    In patients with traumatic brain injury as well as stroke, impaired cerebral oxidative energy metabolism may be an important factor contributing to the ultimate degree of tissue damage. We hypothesize that mitochondrial dysfunction can be diagnosed bedside by comparing the simultaneous changes...... in brain tissue oxygen tension (PbtO(2)) and cerebral cytoplasmatic redox state. The study describes cerebral energy metabolism during mitochondrial dysfunction induced by sevoflurane in piglets....

  8. Parental age, genetic mutation, and cerebral palsy.

    OpenAIRE

    Fletcher, N A; Foley, J

    1993-01-01

    Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.

  9. Cerebral palsy in very low birthweight infants.

    OpenAIRE

    Cooke, R W

    1990-01-01

    Eighty one very low birthweight survivors with cerebral palsy were matched with controls by sex, gestational age, and place of birth. Using discriminant analysis, the perinatal profiles for infants with cerebral palsy and their controls were shown to differ significantly. When infants with various types of cerebral palsy were analysed with their controls the discriminating variables differed. Diplegic infants could be differentiated from controls on antenatal variables alone, but significant ...

  10. Evaluation measures for children with cerebral palsy

    OpenAIRE

    Sršen, Katja Groleger

    2013-01-01

    Abstract. Cerebral palsy is a well-recognized neurodevelopmental condition. The most recentdefinition describes cerebral palsy as a group of disorders of movement andposture, causing activity limitation. An important step in the process of(re)habilitation is evaluation of functional abilities of an individual. To beas accurate as possible in the evaluation of functioning, proper measurementinstruments have to be used. There are many different measurement tools forchildren with cerebral palsy,...

  11. Epilepsy in children with cerebral palsy

    OpenAIRE

    Bruck Isac; Antoniuk Sérgio Antônio; Spessatto Adriane; Bem Ricardo Schmitt de; Hausberger Romeu; Pacheco Carlos Gustavo

    2001-01-01

    OBJECTIVE: To describe the prevalence and characteristics of epilepsy in patients with cerebral palsy in a tertiary center. METHODS: a total of 100 consecutive patients with cerebral palsy were retrospectively studied. Criteria for inclusion were follow-up period for at least 2 years. Types and incidence of epilepsy were correlated with the different forms of cerebral palsy. Other factors associated with epilepsy such as age of first seizure, neonatal seizures and family history of epilepsy w...

  12. Aborto inducido: ética y derechos

    Directory of Open Access Journals (Sweden)

    Montserrat Sagot Rodríguez

    2002-09-01

    Full Text Available Si bien la interrupción voluntaria del embarazo es una práctica común en todo el mundo, el tema es sumamente controversias ya que en él se conjugan aspectos fundamentales como el inicio de la vida humana, el derecho de las mujeres a controlar su propio cuerpo, la sexualidad, la naturaleza de las responsabilidades del Estado para interferir en este terreno y las tensiones entre las visiones seculares y religiosas sobre la vida. El debate permite precisamente visibilizar el hecho de que sobre estos temas no existen visiones homogéneas e inmutables. En ese sentido, a pesar de que en muchos países existen leyes que penalizan el aborto, el asunto nos remite al terreno de principios morales y éticos contrapuestos. Aquí se discuten algunas de las implicaciones de estas controversias y se brinda información sobre la incidencia del aborto, así como sobre las consecuencias tanto del aborto inseguro como de la despenalización. Finalmente, se analizan las implicaciones de la penalización del aborto para el cumplimiento de algunos derechos fundamentales como el respeto a las diferencias, la libre elección, la autodeterminación y la tolerancia.Although abortion is commonly practiced throughout the world, it is a subject that arouses controversy because it raises fundamental questions about human existence, such as when life begins, the right of women to control their own bodies, sexuality, the nature of the State's duties in this matter, and the tension between secular and religious views of human life. This debate allows to make visible the fact that there are no homogencous or unchanging views on these subjects. In that sense, although in many countries the practice of abortion is iIlegal, the issue remits us more to the level of moral and ethical principles. In this article we discuss some of the implications of these controversies and provide information about the incidence of abortion, as well as of the consequences of both unsafe abortion and legalization of the practice. Finally, we analyze the implications of the laws that criminalize abortion on behalf of the fulfillment of some fundamental rights, such as the respect to differences, freedom of choice, self-determination and tolerance.

  13. Aborto inducido: ética y derechos

    OpenAIRE

    Montserrat Sagot Rodríguez; Ana Carcedo Cabañas

    2002-01-01

    Si bien la interrupción voluntaria del embarazo es una práctica común en todo el mundo, el tema es sumamente controversias ya que en él se conjugan aspectos fundamentales como el inicio de la vida humana, el derecho de las mujeres a controlar su propio cuerpo, la sexualidad, la naturaleza de las responsabilidades del Estado para interferir en este terreno y las tensiones entre las visiones seculares y religiosas sobre la vida. El debate permite precisamente visibilizar el hecho de que sobre e...

  14. A study on the pathogenesis of human cerebral malaria and cerebral babesiosis

    Directory of Open Access Journals (Sweden)

    Masamichi Aikawa

    1992-01-01

    Full Text Available Cerebral complications are important, but poorly understood pathological features of infections caused by some species of Plasmodium and Babesia. Patients dying from P. falciparum were classified as cerebral or non-cerebral cases according to the cerebral malaria coma scale. Light microscopy revealed that cerebral microvessels of cerebral malaria patients were field with a mixture of parazited and unparazited erythrocytes, with 94% of the vessels showing parasitized red blood cell (PRBC sequestration. Some degree of PRBC sequestration was also found in non-cerebral malaria patients, but the percentage of microvessls with sequestered PRBC was only 13% Electron microscopy demonstrated knobs on the membrane of PRBC that formed focal junctions with the capillary endothelium. A number of host cell molecules such as CD36, thrombospondim (TSP and intracellular adhesion molecule I (ICAM-1 may function as endothelial cell surfacereports for P. falciparum-infected erythrocytes. Affinity labeling of CD36 and TSP to the PRBC surface showed these molecules specifically bind to the knobs. Babesia bovis infected erythrocytes procedure projections of the erythrocyte membrane that are similar to knobs. When brain tissue from B. bovis-infected cattle was examined, cerebral capillaries were packed with PRBC. Infected erythrocytes formed focal attachments with cerebral endothelial cells at the site of these knob-like projections. These findings indicate that cerebral pathology caused by B. bovis is similar to human cerebral malaria. A search for cytoadherence proteins in the endothelial cells may lead to a better understanding of the pathogenisis of cerebral babesiosis.

  15. Cerebral hemodynamics in aging : the interplay between blood pressure, cerebral perfusion, and dementia

    NARCIS (Netherlands)

    Claassen, J.A.H.R.

    2008-01-01

    Advances in measurement techniques have made it possible to study dynamic changes in brain blood flow. Transcranial Doppler ultrasonography measures changes in cerebral blood flow-velocity in the larger cerebral arteries (e.g. the middle cerebral artery). Near infrared spectroscopy records changes i

  16. Cerebral Palsy. Fact Sheet = La Paralisis Cerebral. Hojas Informativas Sobre Discapacidades.

    Science.gov (United States)

    National Information Center for Children and Youth with Disabilities, Washington, DC.

    This fact sheet on cerebral palsy is written in both English and Spanish. First, it provides a definition of cerebral palsy and considers various causes (e.g., an insufficient amount of oxygen reaching the fetal or newborn brain). The fact sheet then offers incidence figures and explains characteristics of the three main types of cerebral palsy:…

  17. Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers

    DEFF Research Database (Denmark)

    Berg, Ronan Mg; Plovsing, Ronni R; Evans, Kevin A;

    2013-01-01

    Sepsis may be associated with disturbances in cerebral oxygen transport and cerebral haemodynamic function, thus rendering the brain particularly susceptible to hypoxia. The purpose of this study was to assess the impact of isocapnic hypoxia and hyperoxia on dynamic cerebral autoregulation in a h...

  18. Cerebritis: An unusual complication of Klebsiella pneumoniae

    Directory of Open Access Journals (Sweden)

    Majumdar Mainak

    2009-01-01

    Full Text Available Cerebritis is part of a continuum of brain infection and is difficult to diagnose. Cerebritis caused by Klebsiella in immunocompetent adults without predisposing factors such as neurosurgery or penetrating brain injury has not been reported before. We report a case of Klebsiella cerebritis in an adult patient with a proven extracranial focus of infection. We suggest considering cerebritis as a differential diagnosis for altered level of consciousness in patients of severe sepsis, even if an extracranial source of infection is proven.

  19. Alterações sialoquímicas e sialométricas de pacientes com paralisia cerebral: uma revisão de literatura Sialochemical and sialometric alterations in patients with cerebral palsy: a literature review

    OpenAIRE

    Miriam Yumi Matsui; Maria Julia Pereira Coelho Ferraz; Mônica Fernandes Gomes; Cybelle Mori Hiraoka

    2011-01-01

    TEMA: paralisia cerebral e alterações salivares. O paciente com paralisia cerebral é acometido por diversas desordens no Sistema Estomatognático, sendo muitas delas expressas sob a forma de alterações no fluxo e composição salivar. A variação da concentração de constituintes da saliva está diretamente relacionada com sua capacidade tampão, antioxidante, imunológica, digestiva e lubrificante, além de sofrer variações em função da velocidade do fluxo salivar, o qual está intimamente relacionado...

  20. Valoración de la sobrecarga del cuidador del niño con parálisis cerebral

    OpenAIRE

    Ajo San José, Andrea

    2015-01-01

    La parálisis cerebral infantil se caracteriza por un conjunto de trastornos del desarrollo del movimiento y la postura, debido a una lesión cerebral que se desarrolla en estadíos tempranos de la maduración. La atención del niño con éste trastorno implica una cantidad de cuidados y de tiempo del que a veces las familias no disponen, y generalmente estas atenciones las asume una sola persona; el cuidador principal, que en la mayoría de los casos es la madre. El objeto fundamental del presente t...

  1. Babesiose cerebral em bovinos: 20 casos

    Directory of Open Access Journals (Sweden)

    Rodrigues Aline

    2005-01-01

    Full Text Available Num estudo retrospectivo de 1.071 necropsias de bovinos, foram encontrados 20 casos de babesiose cerebral confirmados pelo exame de esfregaços do córtex telencefálico. A maioria desses casos ocorreu no verão, em bovinos adultos de raças européias ou suas cruzas. Além dos sinais clínicos neurológicos, observou-se hemoglobinúria, anorexia, febre, taquicardia, taquipnéia e queda na produção de leite. O hemograma realizado em cinco bovinos afetados revelou acentuada anemia regenerativa; em média, 20% dos eritrócitos estavam parasitados por Babesia bovis. Na necropsia de todos os casos, a substância cinzenta dos córtices telencefálico e cerebelar e dos núcleos da base era consistente e caracteristicamente róseo-cereja. Essa coloração devia-se ao seqüestro de eritrócitos nos capilares encefálicos. Nesses eritrócitos, podiam-se observar, tanto em esfregaços do córtex como em preparações histológicas do encéfalo, microorganismos com morfologia compatível com B. bovis. Outros achados de necropsia incluíam hemoglobinúria, rins vermelho-escuros, hepatoesplenomegalia, fígado vermelho-alaranjado, icterícia, hemorragias epicárdicas e endocárdicas e edema e congestão dos linfonodos mesentéricos.

  2. Estudio del daño por hidrógeno en uniones soldadas de un acero API 5L X52

    Directory of Open Access Journals (Sweden)

    Réquiz, R.

    2008-04-01

    Full Text Available The main objective of the present investigation was to study the susceptibility to hydrogen damage on a type API 5L X52 steel welded by electrical resistance. Several techniques, such as hydrogen permeation and cathodic charging were used. The metallic material was characterized using SEM and TEM. The base metal microstructure was very similar to that one corresponding to the welded area. This microstructure was mainly comprised by ferrite and perlite, differing only in the grain size. Therefore, the susceptibility to hydrogen damage was similar in both cases. It is worth mentioning that the welded area has very small dimensions. Indeed, the fusion zone is only 5 mm wide while the heat affected zone is 1 mm wide. The hydrogen damage observed was mainly in the form of blisters, which were associated to the presence of aluminum rich inclusions. Also, it was noticed partial inclusion dissolution and some matrix attack adjacent to the inclusions.

    En la presente investigación se estudió la susceptibilidad al daño por hidrógeno en un acero API 5L X52 soldado por resistencia eléctrica. Para ello, se emplearon técnicas de permeación y de carga catódica de hidrógeno. El material fue caracterizado mediante microscopía electrónica de barrido y de transmisión. La susceptibilidad al daño por hidrógeno fue similar tanto en el metal base como en el cordón de soldadura. Este comportamiento se vincula a la microestructura homogénea constituida por perlita y ferrita, que presentan ambos, aun cuando existen diferencias en el tamaño de grano. El cordón de soldadura tenía dimensiones muy pequeñas, donde la zona de fusión y la afectada por el calor poseen espesores de 5 mm y 1 mm, respectivamente. El daño inducido por hidrógeno se presentó en forma de ampollas en la superficie del material, asociado, principalmente, a la presencia de inclusiones globulares y semiglobulares ricas en aluminio. Además, se manifestó una disoluci

  3. Guía de manejo cognitivo y conductual de personas con daño cerebral. Manual para profesionales que trabajan en la rehabilitación de personas con daño cerebral. Colección Manuales y Guías. Serie: Dependencia

    OpenAIRE

    Bilbao Bilbao, Álvaro; Díaz, José Luis

    2008-01-01

    Una lesión cerebral puede dar lugar a múltiples discapacidades, por lo que la rehabilitación correspondiente precisa una intervención multidisciplinar. Pero para que la rehabilitación sea exitosa, se requiere también un gran esfuerzo por parte del paciente. De esta convicción parten los autores de este documento, un manual de rehabilitación de personas con daño cerebral, dirigido a profesionales que quieran fomentar la participación del usuario en el trabajo rehabilitador. El manual ayuda a e...

  4. Sotos syndrome (cerebral gigantism: analysis of 8 cases Síndrome de Sotos (gigantismo cerebral: análise de 8 casos

    Directory of Open Access Journals (Sweden)

    Débora Gusmão Melo

    2002-06-01

    Full Text Available Sotos syndrome or cerebral gigantism is characterized by macrocephaly, overgrowth, mental retardation and central nervous system abnormalities. Congenital heart defects may be present. We report 8 patients with this syndrome and relate their clinical features, neuroimaging and echocardiographic findings.A síndrome de Sotos ou gigantismo cerebral é caracterizada por macrocefalia, hipercrescimento, dismorfias faciais típicas, deficiência mental e alterações do sistema nervoso central. Malformações cardíacas podem estar presentes. Nós relatamos 8 pacientes com esta síndrome e descrevemos seus achados clínicos, de neuroimagem e ecocardiográficos.

  5. Estimulación magnética cerebral

    Directory of Open Access Journals (Sweden)

    Luis Carlos Núñez López

    2013-10-01

    Full Text Available La Estimulación Magnética Tras-craneal (EMT es un método no invasivo, indoloro y seguro que permite la MODULACIÓN DE LA ACTIVIDAD CEREBRAL. Está técnica se ha venido implementando desde hace dos décadas, tanto en laboratorios de neurofisiología clínica como en laboratorios de investigación en neurociencia básica. La EMT técnica se caracteriza por tener muy buena resolución espacio temporal, para evaluar funcionalidad de diferentes áreas cerebrales, a un costo permisivo y con el importante valor agregado de tener un gran potencial terapéutico.

  6. Clinicopathological features of cerebral lipoastrocytoma

    Directory of Open Access Journals (Sweden)

    Shuang WEN

    2014-01-01

    Full Text Available Objective To explore the clinicopathological features, immune phenotype, diagnosis and differential diagnosis, treatment and prognosis of cerebral lipoastrocytoma. Methods Retrospective analysis of the clinical manifestations, histopathological and immunohistochemical features were conducted in one case of cerebral lipoastrocytoma. Results A 48-year-old male presented with numbness and inflexibility of the fourth and little fingers of his left hand over the previous 2 weeks. Cranial MRI revealed a space-occupying lesion with cystic degeneration in the right parietal lobe that showed obvious enhancement after contrast administration. The patient subsequently underwent craniotomy with stereotactic gross total excision of the lesion. Adjuvant chemotherapy and radiation therapy were not administered. Histologically the tumor showed classical features of low-grade astrocytoma, including a few scattered medium-large neuron-like cells with prominent nucleoli and abundant cytoplasm. Most notably, the glial cells contained fat droplets or vacuoles giving an appearance of mature adipocytes. Focally microcystic change was evident resulting from adipocyte-like cells fusion with each other. Immunohistochemically, the tumor cells were reactive for glial fibrillary acidic protein (GFAP and S-100 protein (S-100, focally positive for WT-1, weakly positive for oligodendrocytes transcription factor-2 (Olig-2, and negative for isocitrate dehydrogenase 1 (IDH1. Meanwhile, the tumor cells also expressed several neuronal markers including synaptophysin (Syn, microtube-associated protein-2 (MAP-2, neurofilament (NF, neuron specific enolase (NSE and CD34. P53 protein was weakly expressed in 5% of tumor cells. Ki-67 labeling index was low (1% . The patient remained well without recurrence 20 months after surgery. Conclusions Cerebral lipoastrocytoma is an extremely rare tumor. Histologically, the tumor showed classical features of low-grade astrocytoma and extensive

  7. Sumatriptan and cerebral perfusion in healthy volunteers.

    Science.gov (United States)

    Scott, A K; Grimes, S; Ng, K; Critchley, M; Breckenridge, A M; Thomson, C; Pilgrim, A J

    1992-04-01

    1. The effect of sumatriptan on regional cerebral perfusion was studied in healthy volunteers. 2. Intravenous sumatriptan (2 mg) had no detectable effect on regional cerebral perfusion as measured using a SPECT system with 99technetiumm labelled hexemethylpropyleneamineoxime. 3. Sumatriptan had no effect on pulse, blood pressure or ECG indices. 4. All six volunteers experienced minor adverse effects during the intravenous infusion.

  8. Assistive technology for people with cerebral palsy

    OpenAIRE

    Zupan, Anton; Jenko, Mojca

    2013-01-01

    Abstract. Assistive technology includes equipment, devicesand software solutions that increase functional capabilities of people withdisabilities and improve the quality of their lives. The article presentsassistive technology for people with cerebral palsy. These are mobility aidsthat enable people with cerebral palsy independent walking. For those whocannot walk, proper seating is very important. People, who cannot propel manualwheelchair, can control electric wheelchair with various contro...

  9. Cerebral emboli and depressive symptoms in dementia.

    NARCIS (Netherlands)

    Purandare, N.; Oude Voshaar, R.C.; Hardicre, J.; Byrne, J.; McCollum, C.N.; Burns, A.

    2006-01-01

    BACKGROUND: The vascular depression hypothesis and our recent findings of increased frequency of spontaneous cerebral emboli in dementia suggest that such emboli may be involved in the causation of depressive symptoms in dementia. AIMS: To evaluate the association between spontaneous cerebral emboli

  10. Ataxic cerebral palsy and genetic predisposition.

    OpenAIRE

    Miller, G.

    1988-01-01

    It was calculated that in the 962 family members of 36 patients with ataxic cerebral palsy there were 75 (8%) with a history of neurodevelopmental disorder and 31 (3%) with a major congenital malformation. This was not significantly greater than expected, and does not support the hypothesis of a genetic non-Mendelian role in the aetiology of ataxic cerebral palsy.

  11. Fatal cerebral oedema in adult diabetic ketoacidosis.

    NARCIS (Netherlands)

    Haringhuizen, A.; Tjan, D.H.; Grool, A.; Vugt, R. van; Zante, A.R. van

    2010-01-01

    In this report, a case of adult onset fatal cerebral oedema as a rare complication of diabetic ketoacidosis (DKA) is described and confirmed at post-mortem pathological examination. The pathogenesis of cerebral oedema due to DKA is still unknown. Potential mechanisms include the administration of so

  12. Mobility Experiences of Adolescents with Cerebral Palsy

    Science.gov (United States)

    Palisano, Robert J.; Shimmell, Lorie J.; Stewart, Debra; Lawless, John J.; Rosenbaum, Peter L.; Russell, Dianne J.

    2009-01-01

    The purpose of this study was to describe how youth with cerebral palsy experience mobility in their daily lives using a phenomenological approach. The participants were 10 youth with cerebral palsy, 17 to 20 years of age, selected using purposeful sampling with maximum variation strategies. A total of 14 interviews were completed. Transcripts…

  13. Se los por se lo

    OpenAIRE

    José Luis Rivarola

    1985-01-01

    El sistema de la conjugación "objetiva" plantea interesantesproblemas que fueron tratados en parte por K. Heger (1966) en suestudio comparativo del francés y del español. De la comparaciónse desprende, por ejemplo, que en español hay un cierto número deambigüedades que no permiten establecer un "paradigma tan completo y unívoco" como en el caso del francés. Dentro de estas ambigüedades se encuentran las que propicia el gramema se: "El morfema [gramema] se funciona no sólo como pronombre refle...

  14. Ptose palpebral causada por Paquidermoperiostose

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    Patricia Regina de Pinho Tavares

    2014-08-01

    Full Text Available A paquidermoperiostose é uma síndrome caracterizada por acometimento cutâneo e ósseo, e em alguns casos ocorre comprometimento palpebral leve. É uma síndrome rara, idiopática ou hereditária, com provável herança autossômica dominante de penetrância variável. Descreve-se o caso de um paciente com ptose grave por paquidermoperiostose elucidando sua fisiopatologia e conduta cirúrgica aplicada.

  15. Cerebral oximetry in cardiac anesthesia

    Science.gov (United States)

    Vretzakis, George; Georgopoulou, Stauroula; Stamoulis, Konstantinos; Stamatiou, Georgia; Tsakiridis, Kosmas; Katsikogianis, Nikolaos; Kougioumtzi, Ioanna; Machairiotis, Nikolaos; Tsiouda, Theodora; Mpakas, Andreas; Beleveslis, Thomas; Koletas, Alexander; Siminelakis, Stavros N.; Zarogoulidis, Konstantinos

    2014-01-01

    Cerebral oximetry based on near-infrared spectroscopy (NIRS) is increasingly used during the perioperative period of cardiovascular operations. It is a noninvasive technology that can monitor the regional oxygen saturation of the frontal cortex. Current literature indicates that it can stratify patients preoperatively according their risk. Intraoperatively, it provides continuous information about brain oxygenation and allows the use of brain as sentinel organ indexing overall organ perfusion and injury. This review focuses on the clinical validity and applicability of this monitor for cardiac surgical patients. PMID:24672700

  16. Cerebral salt wasting syndrome: review.

    Science.gov (United States)

    Cerdà-Esteve, M; Cuadrado-Godia, E; Chillaron, J J; Pont-Sunyer, C; Cucurella, G; Fernández, M; Goday, A; Cano-Pérez, J F; Rodríguez-Campello, A; Roquer, J

    2008-06-01

    Hyponatremia is the most frequent electrolyte disorder in critically neurological patients. Cerebral salt wasting syndrome (CSW) is defined as a renal loss of sodium during intracranial disease leading to hyponatremia and a decrease in extracellular fluid volume. The pathogenesis of this disorder is still not completely understood. Sympathetic responses as well as some natriuretic factors play a role in this syndrome. Distinction between SIADH and CSW might be difficult. The essential point is the volemic state. It is necessary to rule out other intermediate causes. Treatment requires volume replacement and maintenance of a positive salt balance. Mineral corticoids may be useful in complicated cases.

  17. ECG changes during cerebral angiography

    Energy Technology Data Exchange (ETDEWEB)

    Hayakawa, K.; Nishimura, Y.; Yoshida, M.; Itoh, K.; Hayashi, N.; Aoki, J.; Nakamura, K.; Imai, M.; Ono, T.; Morikawa, S.

    1984-09-01

    We have analyzed HR changes greater than 20% among 334 patients and 942 cerebral angiographies. A tachycardial effect was seen in 14.9% of patients, while a bradycardial effect was seen in 7.1% including two patients having cardiac standstill (0.5%). These two patients were examined without atropine premedication after subarachnoid hemorrhage. Patients under 19 years of age, unpremedicated with atropine sulfate and suffering from subarachnoid hemorrhage secondary to ruptured aneurysm or arteriovenous malformation showed a significantly high incidence of bradycardia. On the other hand, patients with the neoplastic disease and having an initial sinus bradycardia showed a significantly high incidence of a tachycardial effect.

  18. Trombose venosa cerebral e homocistinúria: relato de caso Cerebral venous thrombosis and homocystinuria: case report

    Directory of Open Access Journals (Sweden)

    Gisele Sampaio Silva

    2001-09-01

    Full Text Available Homocistinúria apresentando-se como trombose venosa cerebral é incomum. Relatamos o caso de um adolescente com características fenotípicas de homocistinúria que foi admitido por cefaléia intensa, vômitos e sonolência. Investigação diagnóstica com tomografia computadorizada de crânio, ressonância magnética e angiorressonância foi compatível com trombose dos seios transversos e sigmóides. Altos níveis de homocisteína foram detectados no sangue e na urina. Apresentamos os aspectos clínicos e radiológicos deste caso discutindo a controversa fisiopatologia da tendência trombofílica associada a homocistinúria.Homocystinuria presenting as cerebral venous thrombosis is not usual. We report on a 13-year-old boy who was admitted to the hospital due to severe headache, nausea, vomiting and fever (38ºC. The patient was Marfan like and presented left hemiparesis and meningeal irritation sings. He was mentally retarded, had severe myopia, and had right lens dislocation one month before. Cranial CT scan was suggestive of cerebral venous infarct. MRI and magnetic resonance angiography showed venous infarcts more prominent in the right thalamic projection with hemorrhagic transformation and multiple foci of cortical (occipital and parietal bilaterally deep parietal and left capsular bleeding, secondary of thrombosis of the transverse and sigmoid venous sinuses. High levels of homocysteine were detected in the blood and urine. Homocystinuria is an autossomal recessive inborn error of methionine metabolism caused by cystathione-ß-synthase defect in most cases. We discuss the clinical and radiological findings in this patient, analyzing the pathophysiology of the thrombotic events related to homocystinuria.

  19. Coriocarcinoma manifestando-se inicialmente como um tumor cerebral Metastatic cerebral chorioncarcinoma simulating a primary brain tumor

    Directory of Open Access Journals (Sweden)

    José Alberto G. da Silva

    1971-09-01

    Full Text Available Os autores descrevem um caso de coriocarcinoma cerebral metastático, removido cirurgicamente, ocorrendo numa paciente de 19 anos e localizado na porção posterior do lobo frontal esquerdo. Um estudo retrospectivo da paciente revelou apenas discreta perda sangüínea pelos genitais, iniciada algumas semanas após o delivramento de uma criança normal, ocorrido quatro meses antes. O exame colpocitológico da secreção cérvico-vaginal revelou uma classe V de Papanicolau (positivo para células neoplásicas malignas, tendo ulteriormente a paciente sido submetida à histerectomia total com anexectomia bilateral. Um pequeno tumor de aspecto hemorrágico-necrótico foi encontrado na cavidade uterina, tendo o exame histológico mostrado tratar-se de coriocarcinoma. Os autores tecem considerações clínico-patológicas sobre o coriocarcinoma. com especial referência às lesões metastáticas cerebrais.A case of a metastatic cerebral chorioncarcinoma in the posterior aspect of the left frontal lobe of a 19-years-old woman is reported. After neurosurgical excision of the brain tumor a retrospective study of the patient was carried out as far as the gynecologic complaints were concerned. The patient complained only of little blood loss through the genitals started some weeks after the birth of a normal child four months ago. A smear vaginal preparation showed the presence of atypical epithelial cells (class V of Papanicolau. A total hysterectomy associated with bilateral anexectomy was performed. A small hemorrhagic tumor was detected within the uterus and a histological examination showed a chorioncarcinoma invading the miometrium. The clinico-pathological aspects of the chorioncarcinoma with special emphasis to cerebral metastases are discussed.

  20. Alternativa terapeutica en la isquemia cerebral empleando la Eritropoyetina humana recombinante (rHu-EPO CIM como neuroprotector.

    Directory of Open Access Journals (Sweden)

    Iliana Sosa Testé

    2005-01-01

    Full Text Available Las enfermedades vasculares constituyen las terceras causas de muerte en Cuba. Su variante isquémica es causa de invalidez y perdida de la calidad de la vida. La búsqueda de agentes neuroprotectores es muy importante sí tenemos en cuenta que nuestra población está envejecida. Muchos son las razones por la que una molécula con propiedades neuroprotectoras en los modelos animales no tenga los resultados en ensayos clínicos en humanos. Este trabajo analiza y discute como mejorar estos aspectos. La Eritropoyetina humana recombinante (rHu EPO, conocido por su papel en la diferenciación del eritrocito, ha mostrado ser neuroprotector durante la isquemia cerebral en los modelos de animales adultos. De esta molécula se exponen los mecanismos de acción, que son las bases de los resultados positivos alcanzaron en las investigaciones preclínicas y los ensayos clínicos, que lo proponen como el neuroprotector ideal. Finalmente se comparan los resultados alcanzados por los autores en las investigaciones con la rHu EPO producida por el Centro Molecular de Inmunología de Cuba (CIM. El efecto de la aplicación de rHu EPO se evidenció por la disminución del edema cerebral, preservación de la conducta exploratoria y la disminución de la incidencia de señales clínicas de infarto cerebral y alteraciones patológicas. El grupo de resultados demostró las diferencias significantes entre los animales controles y tratados con el rHu EPO con los no tratados que sugieren que el rHu EPO debe ser considerado como una alternativa terapéutica contra el infarto cerebral en su fase aguda.

  1. Capacidad antiteratogénica del resveratrol en diabetes inducida por estreptozotocina en ratas

    Directory of Open Access Journals (Sweden)

    Ninna Leslie Trejo-González

    2015-07-01

    Full Text Available Objetivos. Evaluar la capacidad antihiperglucémica y antiteratogénica del resveratrol en ratas inducidas a diabetes por estreptozotocina. Materiales y métodos. Estudio de tipo experimental. Se tuvieron tres grupos, de cinco ratas Wistar preñadas cada uno, dos de los cuales fueron tratados el cuarto día de gestación con una dosis de estreptozotocina de 50 mg/kg, disuelta en tampón de citratos, y el otro fue considerado como control, y solo se le administró el tampón de citratos. A uno de los grupos inducidos con estreptozotocina se le administró resveratrol a dosis de 100 mg/kg durante los días 8 al 12 de gestación, cuando sucede la neurulación. Los fetos se obtuvieron el día 19 de gestación y se les realizó un análisis morfológico, y en el hígado fetal se determinó la actividad de las enzimas depuradoras de especies reactivas catalasa, superóxido dismutasa y glutatión peroxidasa. Resultados. La administración de resveratrol (DM+R revierte los parámetros a valores similares a los del grupo control. Las actividades de catalasa y de glutatión peroxidasa, se vieron incrementadas en el grupo tratado con resveratrol con respecto al grupo diabético, en cuanto a la frecuencia de malformaciones en el grupo control y en el grupo tratado con resveratrol no presentaron malformaciones, mientras que en las ratas con diabetes inducida, se encontró una elevada frecuencia de malformaciones. Conclusiones. El resveratrol muestra propiedades antiteratogénicas a través de la disminución del estrés oxidativo que se presenta a causa de la hiperglucemia materna

  2. Capacidad antiteratogénica del resveratrol en diabetes inducida por estreptozotocina en ratas

    Directory of Open Access Journals (Sweden)

    Ninna Leslie Trejo-González

    2015-09-01

    Full Text Available Objetivos. Evaluar la capacidad antihiperglucémica y antiteratogénica del resveratrol en ratas inducidas a diabetes por estreptozotocina. Materiales y métodos. Estudio de tipo experimental. Se tuvieron tres grupos, de cinco ratas Wistar preñadas cada uno, dos de los cuales fueron tratados el cuarto día de gestación con una dosis de estreptozotocina de 50 mg/kg, disuelta en tampón de citratos, y el otro fue considerado como control, y solo se le administró el tampón de citratos. A uno de los grupos inducidos con estreptozotocina se le administró resveratrol a dosis de 100 mg/kg durante los días 8 al 12 de gestación, cuando sucede la neurulación. Los fetos se obtuvieron el día 19 de gestación y se les realizó un análisis morfológico, y en el hígado fetal se determinó la actividad de las enzimas depuradoras de especies reactivas catalasa, superóxido dismutasa y glutatión peroxidasa. Resultados. La administración de resveratrol (DM+R revierte los parámetros a valores similares a los del grupo control. Las actividades de catalasa y de glutatión peroxidasa, se vieron incrementadas en el grupo tratado con resveratrol con respecto al grupo diabético, en cuanto a la frecuencia de malformaciones en el grupo control y en el grupo tratado con resveratrol no presentaron malformaciones, mientras que en las ratas con diabetes inducida, se encontró una elevada frecuencia de malformaciones. Conclusiones. El resveratrol muestra propiedades antiteratogénicas a través de la disminución del estrés oxidativo que se presenta a causa de la hiperglucemia materna

  3. CT findings in patients with cerebral palsy

    Energy Technology Data Exchange (ETDEWEB)

    Konno, K. (Akita Univ. (Japan))

    1982-01-01

    Clinical findings and CT findings in 73 cases of cerebral palsy were studied. The causes of cerebral palsy were presumed to be as follows: abnormal cerebral development (36%), asphyxial delivery (34%), and immature delivery (19%), etc. CT findings were abnormal in 58% of the 73 cases, 83% of the spastic tetraplegia patients and all of the spastic hemiplegia patients showed abnormal CT findings. All the patients with spastic monoplegia presented normal CT findings. In 75% of the spastic hemiplegia cases, the CT abnormalities were due to cerebral parenchymal abnormality such as porencephaly and regional low absorption. In cases of spastic tetraplegia, cerebral parenchymal abnormality was found only in 10%. Cortical atrophy was found only in 15 of the 73 cases, whereas central atrophy was found in 36 cases.

  4. CT findings in patients with cerebral palsy

    International Nuclear Information System (INIS)

    Clinical findings and CT findings in 73 cases of cerebral palsy were studied. The causes of cerebral palsy were presumed to be as follows: abnormal cerebral development (36%), asphyxial delivery (34%), and immature delivery (19%), etc. CT findings were abnormal in 58% of the 73 cases, 83% of the spastic tetraplegia patients and all of the spastic hemiplegia patients showed abnormal CT findings. All the patients with spastic monoplegia presented normal CT findings. In 75% of the spastic hemiplegia cases, the CT abnormalities were due to cerebral parenchymal abnormality such as porencephaly and regional low absorption. In cases of spastic tetraplegia, cerebral parenchymal abnormality was found only in 10%. Cortical atrophy was found only in 15 of the 73 cases, whereas central atrophy was found in 36 cases. (Ueda, J.)

  5. Celulitis por citomegalovirus Cytomegalovirus cellulitis

    Directory of Open Access Journals (Sweden)

    A. Ruiz Lascano

    2002-12-01

    Full Text Available Las lesiones cutáneas por citomegalovirus (CMV son infrecuentes y a menudo una manifestación tardía de una enfermedad sistémica, que generalmente anuncia un curso fatal. Comunicamos un caso de celulitis por CMV: una mujer de 70 años con trasplante renal efectuado 1 mes antes de la consulta, terapia inmunosupresora con ciclosporina A y metilprednisona. La paciente ingresó por fiebre, dolor e impotencia funcional en pierna derecha. Comprobamos la existencia de una placa de 8 por 4 cm eritematoedematosa. La tratamos con antibióticos sin mejoría, por lo que realizamos un estudio histopatológico de piel que mostró cambios citopáticos compatibles con infección por CMV. Los cultivos bacteriológicos y micológicos fueron negativos. La inmunohistoquímica específica para CMV y el estudio de reacción en cadena de la polimerasa (PCR de la biopsia de piel fueron positivas, al igual que la antigenemia. El tratamiento con ganciclovir produjo la mejoría del cuadro clínico. En la literatura revisada no hemos encontrado la celulitis como manifestación de enfermedad cutánea por CMV.Cutaneous lesions in CMV infection are rare, often a late manifestation of systemic infection, and usually herald a fatal course. A 70 year-old woman received a kidney transplantation one month before consulting and immunosuppressive therapy that included cyclosporine A and methylprednisone. She complained of fever, local pain in her right leg, and an erythematous and swelling plaque. She was treated with intravenous antibiotics without improvement. A skin biopsy was performed and the tissue obtained was sent for bacterial and fungal cultures as well as for histological examination. Cultures were negative. The biopsy showed CMV cytopathic changes. Immunoperoxidase staining was positive for CMV and polymerase chain reaction (PCR testing revealed CMV DNA. She was treated with ganciclovir with resolution of the lesion. CMV cellulitis is a rare cutaneous manifestation

  6. Cerebral cortex modulation of pain

    Institute of Scientific and Technical Information of China (English)

    Yu-feng XIE; Fu-quan HUO; Jing-shi TANG

    2009-01-01

    Pain is a complex experience encompassing sensory-discriminative, affective-motivational and cognitiv e-emotional com-ponents mediated by different mechanisms. Contrary to the traditional view that the cerebral cortex is not involved in pain perception, an extensive cortical network associated with pain processing has been revealed using multiple methods over the past decades. This network consistently includes, at least, the anterior cingulate cortex, the agranular insular cortex, the primary (SⅠ) and secondary somatosensory (SⅡ) cortices, the ventrolateral orbital cortex and the motor cortex. These corti-cal structures constitute the medial and lateral pain systems, the nucleus submedius-ventrolateral orbital cortex-periaque-ductal gray system and motor cortex system, respectively. Multiple neurotransmitters, including opioid, glutamate, GABA and dopamine, are involved in the modulation of pain by these cortical structures. In addition, glial cells may also be in-volved in cortical modulation of pain and serve as one target for pain management research. This review discusses recent studies of pain modulation by these cerebral cortical structures in animals and human.

  7. [Cerebral vasospasm after subarachnoid hemorrhage].

    Science.gov (United States)

    Milojević, T M; Baljozović, B V; Rakić, M Lj; Nestorović, B D; Dostanić, M M; Milaković, B D; Kojić, Z Z; Repac, N R; Cvrkota, I S

    2008-01-01

    Cerebral vasospasm causes permanent neurolological deficit or death occurance in 13% of clinical cases. Peak frequency is from 8-10th day after SAH. The purpose of this study is factor analysis that may have influence on vasospasm development , as well as predictor determination. The study is prospective and analysis 192 patients treated in Institute of Neurosurgery, Clinical Centre of Serbia, Belgrade. The majority of patients were admitted in hospital in first four days after SAH, and 184 had GCS over 7. Univariate methods of factor analysis were used, and for significance of predictors influence testing multivariante regression analysis was used. Vasospasm occurred in 22,40% of all cases. No relationships have been found between sex, age, previous hypertension, timing of surgery, appearance of hydrocephalus and intracerebral hematoma, hypertermia or mean arterial blood pressure, with occurrence of cerebral vasospasm. Factors with significantly associated with the occurance of vasospasm were: hearth disease, hypernatriemia, Hct, clinical grade on admission as well as preoperative clinical grade and Fisher CT scan grade. In the first four days after SAH, Fisher scan grade, preoperative clinical grade and Hct, appeared as predictors. After four days, clinical grade on admission and hypernatiemia, showed as poredictors. PMID:18792575

  8. Cerebral lateralization in simultaneous interpretation.

    Science.gov (United States)

    Fabbro, F; Gran, L; Basso, G; Bava, A

    1990-07-01

    Cerebral asymmetries for L1 (Italian), L2 (English), and L3 (French, German, Spanish, or Russian) were studied, by using a verbal-manual interference paradigm, in a group of Italian right-handed polyglot female students at the Scuola Superiore di Lingue Moderne per Interpreti e Traduttori (SSLM-School for Interpreters and Translators) of the University of Trieste and in a control group of right-handed monolingual female students at the Medical School of the University of Trieste. In an automatic speech production task no significant cerebral lateralization was found for the mother tongue (L1) either in the interpreting students or in the control group; the interpreting students were not significantly lateralized for the third language (L3), while weak left hemispheric lateralization was shown for L2. A significantly higher degree of verbal-manual interference was found for L1 than for L2 and L3. A significantly higher disruption rate occurred in the meaning-based mode of simultaneous interpretation (from L2 into L1 and vice versa) than in the word-for-word mode (from L2 into L1 and vice versa). No significant overall or hemispheric differences were found during simultaneous interpretation from L1 into L2 or from L2 into L1. PMID:2207622

  9. (phoenicopterus roseus por intoxicación aguda por plomo

    Directory of Open Access Journals (Sweden)

    D Romero

    2007-01-01

    Full Text Available La presencia de plomo en el medio ambiente es un hecho indiscutible. Ello es objeto de gran interés sanitario pues repercute tanto en la salud de los animales como en la del ser humano. El plumbismo es una intoxicación que puede afectar a cualquier especie animal. En el ámbito de la fauna silvestre se asocia principalmente a la actividad cinegética en los humedales y a la ingestión de plomo metálico por parte de las aves que frecuentan estos ecosistemas. En España cada año mueren decenas de miles de aves acuáticas como consecuencia de la ingesta de perdigones de plomo. En los individuos capturados enfermos se pueden observar signos clínicos, mientras que a partir de muestras de cadáveres se obtienen datos sobre niveles tisulares de plomo. Sin embargo la evaluación de lesiones anatomopatológicas en animales de vida silvestre es difícil de realizar por la dificultad de encontrar animales recién muertos o afectados de un cuadro agudo mortal. La reproducción de esta patología en animales de experimentación se suele realizar en cisnes, palomas o patos, pero no en flamencos, por lo que no es usual disponer de datos histológicos en esta especie. En este trabajo presentamos la clínica, analítica y estudio microscópico de diferentes tejidos de un flamenco común (Phoenicopterus roseus muerto por plumbismo.

  10. Aerobic training in children with cerebral palsy.

    Science.gov (United States)

    Nsenga, A L; Shephard, R J; Ahmaidi, S; Ahmadi, S

    2013-06-01

    Rehabilitation is a major goal for children with cerebral palsy, although the potential to enhance cardio-respiratory fitness in such individuals remains unclear. This study thus compared current cardio-respiratory status between children with cerebral palsy and able-bodied children, and examined the ability to enhance the cardio-respiratory fitness of children with cerebral palsy by cycle ergometer training. 10 children with cerebral palsy (Gross Motor Function Classification System levels I and II) participated in thrice-weekly 30 min cycle ergometer training sessions for 8 weeks (mean age: 14.2±1.9 yrs). 10 additional subjects with cerebral palsy (mean age: 14.2±1.8 yrs) and 10 able-bodied subjects (mean age: 14.1±2.1 yrs) served as controls, undertaking no training. All subjects undertook a progressive cycle ergometer test of cardio-respiratory fitness at the beginning and end of the 8-week period. Cardio-respiratory parameters [oxygen intake V˙O2), ventilation V ˙ E) and heart rate (HR)] during testing were measured by Cosmed K4 b gas analyzer. The children with cerebral palsy who engaged in aerobic training improved their peak oxygen consumption, heart rate and ventilation significantly (pchildren with cerebral palsy can benefit significantly from cardio-respiratory training, and such training should be included in rehabilitation programs.

  11. Noninvasive optoacoustic monitoring of cerebral venous blood oxygenation in newborns

    Science.gov (United States)

    Petrov, Irene Y.; Wynne, Karon E.; Petrov, Yuriy; Esenaliev, Rinat O.; Richardson, C. Joan; Prough, Donald S.

    2012-02-01

    Cerebral ischemia after birth and during labor is a major cause of death and severe complications such as cerebral palsy. In the USA alone, cerebral palsy results in permanent disability of 10,000 newborns per year and approximately 500,000 of the total population. Currently, no technology is capable of direct monitoring of cerebral oxygenation in newborns. This study proposes the use of an optoacoustic technique for noninvasive cerebral ischemia monitoring by probing the superior sagittal sinus (SSS), a large central cerebral vein. We developed and built a multi-wavelength, near-infrared optoacoustic system suitable for noninvasive monitoring of cerebral ischemia in newborns with normal weight (NBW), low birth-weight (LBW, 1500 - 2499 g) and very low birth-weight (VLBW, cerebral oxygenation would suggest that no therapy was necessary; conversely, evidence of cerebral ischemia would prompt therapy to increase cerebral blood flow.

  12. The serpentine mitral valve and cerebral embolism

    Directory of Open Access Journals (Sweden)

    Ker James

    2011-02-01

    Full Text Available Abstract Valvular strands, well-delineated filiform masses, attached to cardiac valve edges are associated with cerebral embolism and stroke. Strokes, caused by emboli from valvular strands, tend to occur among younger persons. In this case report a valvular strand, giving a peculiar serpentine appearance to the mitral valve is described. This mitral valvular strand was the only explanation for an episode of cerebral embolism, presenting with a transient right sided hemiparesis. It is proposed that a randomized study involving combined treatment with aspirin and clopidogrel is warranted in young patients with valvular strands, presenting with a first episode of cerebral embolism.

  13. Validation of a cerebral palsy register

    DEFF Research Database (Denmark)

    Topp, Monica Wedell; Langhoff-Roos, J; Uldall, P

    1997-01-01

    OBJECTIVES: To analyse completeness and validity of data in the Cerebral Palsy Register in Denmark, 1979-1982. METHODS: Completeness has been assessed by comparing data from The Danish National Patient Register (DNPR) with the cases included in the Cerebral Palsy Register (CPR). Agreement between......, but gestational age was subject to a systematic error, and urinary infections in pregnancy (kappa = 0.43) and placental abruption (kappa = 0.52) were seriously under-reported in the CPR. CONCLUSIONS: Completeness of the Cerebral Palsy Register in Denmark, 1979-1982, has been assessed to maximal 85%, emphasizing...

  14. Human cerebral circulation. Positron emission tomography studies

    International Nuclear Information System (INIS)

    We reviewed the literature on human cerebral circulation and oxygen metabolism, as measured by positron emission tomography (PET), with respect to normal values and of regulation of cerebral circulation. A multicenter study in Japan showed that between-center variations in cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) values were not considerably larger than the corresponding within-center variations. Overall mean±SD values in cerebral cortical regions of normal human subjects were as follows: CBF=44.4±6.5 ml/100 ml/min; CBV=3.8±0.7 ml/100 ml; OEF=0.44±0.06; CMRO2=3.3±0.5 ml/100 ml/min (11 PET centers, 70 subjects). Intrinsic regulation of cerebral circulation involves several factors. Autoregulation maintains CBF in response to changes in cerebral perfusion pressure; chemical factors such as PaCO2 affect cerebral vascular tone and alter CBF; changes in neural activity cause changes in cerebral energy metabolism and CBF; neurogenic control of CBF occurs by sympathetic innervation. Regional differences in vascular response to changes in PaCO2 have been reported, indicating regional differences in cerebral vascular tone. Relations between CBF and CBV during changes in PaCO2 and during changes in neural activity were in good agreement with Poiseuille's law. The mechanisms of vascular response to neural activation and deactivation were independent on those of responses to PaCO2 changes. CBV in a brain region is the sum of three components: arterial, capillary and venous blood volumes. It has been reported that the arterial blood volume fraction is approximately 30% in humans and that changes in human CBV during changes in PaCO2 are caused by changes in arterial blood volume without changes in venous blood volume. These findings should be considered in future studies of the pathophysiology of cerebrovascular diseases. (author) 136 refs

  15. Trends in birth prevalence of cerebral palsy.

    OpenAIRE

    Pharoah, P O; Cooke, T.; Rosenbloom, I; Cooke, R W

    1987-01-01

    A register of children with cerebral palsy born in the period 1966-77 to mothers resident in the Mersey region was compiled from several different data sources. There were 685 cases, with a male:female ratio of 1.4:1. The birth prevalence of cerebral palsy ranged from 1.18 to 1.97 per 1000 live births each year, with a mean of 1.51 per 1000 live births. There was no discernible trend in overall prevalence, but there was a highly significant upward trend in the prevalence of cerebral palsy amo...

  16. Dihydralazine induces marked cerebral vasodilation in man

    DEFF Research Database (Denmark)

    Schroeder, T; Sillesen, H

    1987-01-01

    Dihydralazine is widely used for acute control of hypertension. In experimental studies it seems to dilate cerebral resistance vessels and increase intracranial pressure. However, the effect on cerebral blood flow (CBF) in man has been little studied. Measurements of CBF were performed with the i...... the period of study, in median 16, 27 and 23% at the three periods of measurements, respectively. The arterial blood pressure remained unchanged, whereas heart rate increased significantly. During CO2 inhalation, CBF increased on average 29%. Thus, the cerebral vasodilation exerted by a small i.v. dose...

  17. Intraaortic Balloon Pump Counterpulsation and Cerebral Autoregulation: an observational study

    OpenAIRE

    Boots Rob; Barnett Adrian G; Timms Daniel; Dunster Kimble; Geng Shureng; Bellapart Judith; Fraser John F

    2010-01-01

    Abstract Background The use of Intra-aortic counterpulsation is a well established supportive therapy for patients in cardiac failure or after cardiac surgery. Blood pressure variations induced by counterpulsation are transmitted to the cerebral arteries, challenging cerebral autoregulatory mechanisms in order to maintain a stable cerebral blood flow. This study aims to assess the effects on cerebral autoregulation and variability of cerebral blood flow due to intra-aortic balloon pump and in...

  18. Cerebral Metabolic Alterations in Rats With Diabetic Ketoacidosis

    OpenAIRE

    Glaser, Nicole; Yuen, Natalie; Anderson, Steven E; Tancredi, Daniel J.; O'Donnell, Martha E.

    2009-01-01

    OBJECTIVE Cerebral edema is a life-threatening complication of diabetic ketoacidosis (DKA) in children. Recent data suggest that cerebral hypoperfusion and activation of cerebral ion transporters may be involved, but data describing cerebral metabolic alterations during DKA are lacking. RESEARCH DESIGN AND METHODS We evaluated 50 juvenile rats with DKA and 21 normal control rats using proton and phosphorus magnetic resonance spectroscopy (MRS). MRS measured cerebral intracellular pH and ratio...

  19. Role of Aquaporin-4 in Cerebral Edema and Stroke

    OpenAIRE

    Zador, Zsolt; Stiver, Shirley; Wang, Vincent; Manley, Geoffrey T.

    2009-01-01

    Cerebral edema plays a central role in the pathophysiology of many diseases of the central nervous system (CNS) including ischemia, trauma, tumors, inflammation, and metabolic disturbances. The formation of cerebral edema results in an increase in tissue water content and brain swelling which, if unchecked, can lead to elevated intracranial pressure (ICP), reduced cerebral blood flow, and ultimately cerebral herniation and death. Despite the clinical significance of cerebral edema, the mechan...

  20. Se los por se lo

    Directory of Open Access Journals (Sweden)

    José Luis Rivarola

    1985-12-01

    Full Text Available El sistema de la conjugación "objetiva" plantea interesantesproblemas que fueron tratados en parte por K. Heger (1966 en suestudio comparativo del francés y del español. De la comparaciónse desprende, por ejemplo, que en español hay un cierto número deambigüedades que no permiten establecer un "paradigma tan completo y unívoco" como en el caso del francés. Dentro de estas ambigüedades se encuentran las que propicia el gramema se: "El morfema [gramema] se funciona no sólo como pronombre reflexivo, sinotambién como variante combinatoria del pronombre personal complemento indirecto de la tercera persona.

  1. por el Tribunal Constitucional chileno

    Directory of Open Access Journals (Sweden)

    Marisol Peña Torres

    2008-01-01

    Full Text Available La modificación introducida por la reforma constitucional de agosto de 1989 al artículo 5º de la Constitución chilena sentó un criterio decisivo en la incorporación del derecho internacional de los derechos humanos al ordenamiento jurídico interno. El artículo examina la jurisprudencia del Tribunal Constitucional antes y después de esa reforma distinguiendo entre la aplicación del Derecho Internacional de los Derechos Humanos por haberse invocado en la acción deducida y la aplicación de principios y criterios hermenéuticos extraídos del mismo.

  2. DETERMINACIÓN DE LOS NIVELES DE FUERZA MÁXIMA APLICADA, VELOCIDAD Y POTENCIA POR MEDIO DE UN TEST CRECIENTE EN PRES DE BANCA PLANO, EN LEVANTADORES ESPAÑOLES.

    Directory of Open Access Journals (Sweden)

    Joaquín Figueroa Alchapar

    2010-10-01

    Full Text Available

     

    Se evaluaron 9 levantadores que realizaron 2 test en el ejercicio de pres debanca: a Progresivo con pesos ligeros a máximos (MRPr b Máxima Repetición (MRD. Semidió la fuerza (FN, velocidad (V y potencia (W con cada peso movilizado,determinándose el máximo peso factible de movilizar 1 vez y no dos (MR Se observaroncorrelaciones significativas entre la MR del test MRPr y la del MRD, la W máxima, absolutay relativa al peso corporal y la MR absoluta y relativa al peso corporal, no se produjerondiferencias significativas (p<0,05 entre la MR obtenidas en el test MRPr y MRD. Se aceptala aplicación del test MRPr para determinar los niveles de FN, V, W, y MR, localizar losniveles de W máxima, con relación al % MR, y determinar el perfil de rendimiento así comolos cambios inducidos por los entrenamientos de fuerza.

    Palabras Clave: Fuerza Máxima, Velocidad, potencia

  3. Sepsis neonatal por Estreptococos Pyogenes

    Directory of Open Access Journals (Sweden)

    Gilberto Rodríguez-Herrera

    2009-09-01

    Full Text Available Se presenta el caso de un paciente masculino, recién nacido a término adecuado para la edad gestacional, quien nace por parto vaginal, con el antecedente de fiebre en la madre durante el periodo de postparto inmediato. Los padres consultan a los 2 días de vida pues le notan dificultad respiratoria, hipoactividad y rechazo a la leche materna. El paciente se interna y se aborda como una sepsis. Durante su estancia en el servicio de neonatología del Hospital Nacional de Niños asocia fallo respiratorio que amerita ventilación mecánica asistida por varios días en diferentes ocasiones, derrame pleural exudativo, convulsiones de origen hipóxico isquémico. Con reporte de hemocultivos positivos por Estreptococos pyogenes. El Estreptococos pyogenes o estreptococo β-hemolνtico del grupo A, fue un problema en los comienzos del siglo pasado, siendo frecuente en las infecciones puerperales y del reciιn nacido. En la actualidad es un germen sumamente raro en los procesos de sepsis neonatal.2 La gravedad de la enfermedad causada por este microorganismo en el periodo neonatal varνa desde una onfalitis crónica de bajo grado a una septicemia, una meningitis fulminante y la muerte.1 El presente artículo pretende hacer un resumen del paciente, con su evolución clínica, radiológica y además ejemplificar todas las complicaciones que tuvimos con este germen tan poco frecuente en la actualidad en sepsis neonatal.

  4. Epilepsy in children with cerebral palsy Epilepsia em crianças com paralisia cerebral

    OpenAIRE

    Isac Bruck; Sérgio Antônio Antoniuk; Adriane Spessatto; Ricardo Schmitt de Bem; Romeu Hausberger; Carlos Gustavo Pacheco

    2001-01-01

    OBJECTIVE: To describe the prevalence and characteristics of epilepsy in patients with cerebral palsy in a tertiary center. METHODS: a total of 100 consecutive patients with cerebral palsy were retrospectively studied. Criteria for inclusion were follow-up period for at least 2 years. Types and incidence of epilepsy were correlated with the different forms of cerebral palsy. Other factors associated with epilepsy such as age of first seizure, neonatal seizures and family history of epilepsy w...

  5. Cerebral hemodynamics in aging : the interplay between blood pressure, cerebral perfusion, and dementia

    OpenAIRE

    Claassen, J.A.H.R.

    2008-01-01

    Advances in measurement techniques have made it possible to study dynamic changes in brain blood flow. Transcranial Doppler ultrasonography measures changes in cerebral blood flow-velocity in the larger cerebral arteries (e.g. the middle cerebral artery). Near infrared spectroscopy records changes in brain cortical tissue concentrations of hemoglobin. These techniques are non-invasive, and can be performed with the subject in supine, sitting or standing position. Together with photoplethysmog...

  6. Malignant cerebral swelling following cranioplasty.

    Science.gov (United States)

    Honeybul, S; Damodaran, O; Lind, C R P; Lee, G

    2016-07-01

    Over the past few years there have been a number of case reports and small cohort studies that have described so called "malignant" cerebral swelling following an uneventful cranioplasty procedure. The pathophysiology remains to be established however it has been suggested that it may be related to a combination of failure of autoregulation and the use of closed vacuum suction drainage. The current study presents three further patients who had had a decompressive hemicraniectomy for ischaemic stroke. If decompressive craniectomy is utilised in the management of neurological emergencies, close attention and wider reporting of this type of complication is required not only to focus attention on possible management strategies, but also to determine which patients are at most risk of this devastating complication. PMID:27189792

  7. Cerebral hyperperfusion following carotid endarterectomy

    DEFF Research Database (Denmark)

    Schroeder, T; Sillesen, H; Sørensen, O;

    1987-01-01

    Serial measurements of cerebral blood flow (CBF) were performed in 56 patients before and one to four times after uncomplicated carotid endarterectomy. The findings were related to the ratio between internal carotid artery (ICA) and common carotid artery (CCA) mean pressures. Within the 1st...... postoperative day CBF increased by a median of 37% in the ipsilateral and 33% in the contralateral hemisphere. Later recordings showed a gradual return of CBF toward the preoperative level. Sixteen patients with an ICA/CCA pressure ratio below 0.7 showed a significantly more pronounced and longer-lasting flow......, occurred in the low pressure ratio group, while the hemispheric asymmetry on average was unchanged in the high pressure ratio group. This relative hyperemia was most pronounced 2 to 4 days following reconstruction. The marked hyperemia, absolute as well as relative, in patients with a low ICA/CCA pressure...

  8. Computed tomography of cerebral palsy

    International Nuclear Information System (INIS)

    Seventy patients who had suffered from severe damages in the brain in their early lives were examined using a CT scanner, DELTA-25. The results are summerized as follows: 1. CT findings of the brain were classified into four groups; (1) low density in 11 cases, (2) atrophy in 23, (3) hydrocephalus in 12, and (4) no findings in 24. 2. The low density in the CT finding was assumed as cystic degeneration due to circulatory disturbance in the cerebral hemispheres in their early developmental stages. 3. The ''acerebrate'' state denotes no or little development in mental and motor functions which is attributed to a severe damage in the developing brain. According to the CT findings, the ''acerebrate'' state was resulted from extensive destruction in the greater part of both hemispheres. (author)

  9. Cerebral astroblastoma: A radiopathological diagnosis

    Directory of Open Access Journals (Sweden)

    Deepak Kumar Singh

    2014-01-01

    Full Text Available Astroblastoma is a rare glial neoplasm whose histogenesis has been clarified recently. It primarily occurs in children and young adults. We are reporting a case of 12-year-old girl child who presented with features of raised intracranial tension and generalized tonic-clonic seizures. Brain magnetic resonance imaging revealed a large well-circumscribed, cystic lesion without perifocal edema, and enhancing mural nodule in right parietal region. A radiological differential diagnosis of pilocytic astrocytoma and cerebral astroblastoma was made. A complete excision was done and histologically the lesion turned out to be an astroblastoma. We review the histology, immunohistochemistry, and imaging features of astroblastoma and survey the current literature, treatment strategies, and prognostic aspects for the management of this rare neoplasm.

  10. Estado nutricional en niños con parálisis cerebral infantil

    Directory of Open Access Journals (Sweden)

    Drianet Castillo Peña

    2014-08-01

    Full Text Available Se realizó un estudio descriptivo, con el objetivo de caracterizar el estado nutricional de los niños que ingresaron en el Hospital Pediátrico Provincial “Mártires de las Tunas”con parálisis cerebral, en el periodo comprendido de enero a diciembre de 2012. La muestra estuvo integrada por 25 niños. La evaluación nutricional se hizo según las tablas cubanas. Se observó que predominó el sexo masculino, siendo más afectado el grupo de mayores de siete años, prevaleció la desnutrición en niños con parálisis cerebral severa. Los déficits nutricionales más frecuentes fueron la anemia, seguido de la hipoalbuminemia

  11. Cerebral palsy in preterm infants

    Directory of Open Access Journals (Sweden)

    Demeši-Drljan Čila

    2016-01-01

    Full Text Available Background/Aim. Cerebral palsy (CP is one of the leading causes of neurological impairment in childhood. Preterm birth is a significant risk factor in the occurrence of CP. Clinical outcomes may include impairment of gross motor function and intellectual abilities, visual impairment and epilepsy. The aim of this study was to examine the relationships among gestational age, type of CP, functional ability and associated conditions. Methods. The sample size was 206 children with CP. The data were obtained from medical records and included gestational age at birth, clinical characteristics of CP and associated conditions. Clinical CP type was determined according to Surveillance of Cerebral Palsy in Europe (SCPE and topographically. Gross motor function abilities were evaluated according to the Gross Motor Function Classification System (GMFCS. Results. More than half of the children with CP were born prematurely (54.4%. Statistically significant difference was noted with respect to the distribution of various clinical types of CP in relation to gestational age (p < 0.001. In the group with spastic bilateral CP type, there is a greater proportion of children born preterm. Statistically significant difference was noted in the functional classification based on GMFCS in terms of gestational age (p = 0.049, children born at earlier gestational age are classified at a higher GMFCS level of functional limitation. The greatest percentage of children (70.0% affected by two or more associated conditions was found in the group that had extremely preterm birth, and that number declined with increasing maturity at birth. Epilepsy was more prevalent in children born at greater gestational age, and this difference in distribution was statistically significant (p = 0.032. Conclusion. The application of antenatal and postnatal protection of preterm children should be a significant component of the CP prevention strategy. [Projekat Ministarstva nauke Republike

  12. Effect of cerebral lymphatic block on cerebral morphology and cortical evoked potential in rats

    Institute of Scientific and Technical Information of China (English)

    Zuoli Xia; Baoling Sun; Mingfeng Yang; Dongmei Hu; Tong Zhao; Jingzhong Niu

    2006-01-01

    BACKGROUND: It has been shown that although brain does not contain lining endothelial lymphatic vessel,it has lymphatic drain.Anterior lymphatic vessel in brain tissue plays a key role in introducing brain interstitial fluid to lymphatic system;however,the significance of lymphatic drain and the affect on cerebral edema remains unclear.OBJECTIVE: To investigate the effect of cerebral lymphatic block on cerebral morphology and cortical evoked potential in rats.DESIGN: Randomized controlled animal study.SETTING: Institute of Cerebral Microcirulation of Taishan Medical College and Department of Neurology of Affiliated Hospital.MATERIALS:A total of 63 healthy adult male Wistar rats weighing 300-350 g were selected in this study.Forty-seven rats were used for the morphological observation induced by lymphatic drain and randomly divided into three groups:general observation group(n=12),light microscopic observation group(n=21)and electronic microscopic observation group(n=14).The rats in each group were divided into cerebral lymphatic block subgroup and sham-operation control subgroup.Sixteen rats were divided into cerebral the effect of cerebral lymphatic block on cortical evoked potential,in which the animals were randomly divided into sham-operation group(n=6)and cerebral lymphatic block group(n=10).METHODS:The experiment was carried out in the Institute of Cerebral Microcirculation of Taishan Medical College from January to August 2003.Rats in cerebral lymphatic block group were anesthetized and separated bilateral superficial and deep cervical lymph nodes under sterile condition. Superior and inferior boarders of lymph nodes were ligated the inputting and outputting channels, respectively, and then lymph node was removed so as to establish cerebral lymphatic drain disorder models. Rats in sham-operation control group were not ligated the lymphatic vessel and removed lymph nodes.and other operations were as the same as those in cerebral lymphatic block group

  13. Comparison of Cerebral Oxygen Saturation and Cerebral Perfusion Computed Tomography in Cerebral Blood Flow in Patients with Brain Injury.

    Science.gov (United States)

    Trofimov, Alexey O; Kalentiev, George; Voennov, Oleg; Grigoryeva, Vera

    2016-01-01

    The purpose of this study was to determine the relationship between cerebral tissue oxygen saturation and cerebral blood volume in patients with traumatic brain injury. Perfusion computed tomography of the brain was performed in 25 patients with traumatic brain injury together with simultaneous SctO2 level measurement using cerebral near-infrared oxymetry. The mean age of the injured persons was 34.5±15.6 years (range 15-65); 14 men, 11 women. The Injury Severity Score (ISS) values were 44.4±9.7 (range 25-81). The Glasgow Coma Score (GCS) mean value before the study was 10.6±2.1 (range 5-13). SctO2 ranged from 51 to 89%, mean 62±8.2%. Cerebral blood volume (CBV) values were 2.1±0.67 ml/100 g (min 1.1; max 4.3 ml/100 g). Cerebral blood flow (CBF) was 31.99±13.6 ml/100 g×min. Mean transit time (MTT) values were 5.7±4.5 s (min 2.8; max 34.3 s). The time to peak (TTP) was 22.2±3.1 s. A statistically significant correlation was found between SctO2 level and cerebral blood volume (CBV) level (R=0.9; pperfusion.

  14. A ínsula e o conceito de bloco cerebral central The insula and the central core concept

    OpenAIRE

    Guilherme Carvalhal Ribas; Evandro de Oliveira

    2007-01-01

    A caracterização anatômica de regiões encefálicas topograficamente bem definidas é particularmente útil para a prática neurocirúrgica por propiciar melhor compreensão da tridimensionalidade das suas estruturas e das lesões que as acometem, e por incitar uma maior sistematização dos seus acessos cirúrgicos. Neste sentido, se destaca no interior de cada hemisfério cerebral, um verdadeiro bloco único composto externamente pela ínsula, internamente pelos núcleos da base e tálamo, e que abriga no ...

  15. Mecanismos de consolación motivacional de la plasticidad sináptica duradera:efectos del envejecimiento cerebral

    OpenAIRE

    Almaguer Melian, William

    2004-01-01

    Nuestros resultados han mostrado que la amígdala está implicada en el reforzamiento motivacional de la LTP y que este proceso depende de la síntesis de nuevas proteínas. Por otra parte, la norepinefrina administrada en dosis bajas fue suficiente para provocar la consolidación de una E-LTP en una L-LTP, en tanto la oxotremorina, un agonista colinérgico, no tuvo igual efecto. Los estudios por microdiálisis cerebral mostraron que la estimulación de la amígdala aumentó la liberación de acetilc...

  16. Evaluation of the antitumor activity of interleukin-12 in an experimental murine model of colorectal cancer induced by 1,2 dimethylhydrazine (DMH Estudio de la respuesta antitumoral de la interleucina-12 en cáncer de colon inducido mediante 1,2-dimetilhidracina (DMH

    Directory of Open Access Journals (Sweden)

    S. Coca

    2005-09-01

    I (p=0.028 and group III (p = 0.019. Other parameters measured, such as biggest tumor size and total tumoral volume were found to be lower in group II, although no statistical differences were found between groups. Only 10% of rats in group I showed moderated/extensive NK cell infiltration, vs. 60% of rats in group II (p = 0.077 and 70% in group III (p = 0.02. Conclusion: The administration of DMH to rodents provides a reliable and consistent means of inducing CRC that may be suitable for the evaluation of anti-cancer therapies. Our findings suggest that IL-12 is effective against the development of experimental CRC. Its antineoplastic effect could be attributed to the stimulus of this cytokine on the intratumoral infiltration of NK cells.Objetivo: la interleucina (IL-12 es una citocina que estimula la proliferación y la actividad citotóxica de los linfocito T y las células natural killer (NK. En trabajos previos se ha observado una relación entre la infiltración intratumoral de células NK y una mayor supervivencia en carcinomas colorrectales (CCR. Existen evidencias de un efecto aditivo en la actividad inmunomoduladora de la asociación de IL-12 con IL-2. Así, nos hemos propuesto el estudio de la capacidad de respuesta inmune antitumoral, tras la administración sistémica de IL-12 sola o combinada con IL-2, en un modelo experimental de CCR inducidos mediante la administración de 1,2-dimetilhidracina (DMH. Método: sesenta y cinco ratas Wistar de 6 semanas a las que se administró en inyección subcutánea una dosis semanal de DMH a razón de 20 mg/kg de peso durante 26 semanas. Finalizado el periodo de inducción, los animales se distribuyeron aleatoriamente en tres grupos. I: grupo control. Grupo II, se administró IL-12 recombinante murina. Grupo III: se administró IL-12, combinada con IL-2. Las ratas se sacrificaron en la semana 30, estudiándose los siguientes parámetros: número y localización de tumores, tamaño y carga tumoral. Se realiz

  17. [Alterations in cerebral perfusion in patients with systemic sclerosis and cognitive impairment].

    Science.gov (United States)

    Moreno-Gutiérrez, Juan; Coria-Moctezuma, Luis Alonso; del Pilar Cruz-Domínguez, María; Vera-Lastra, Olga Lidia

    2015-01-01

    Introducción: la esclerosis sistémica (ES) es una enfermedad autoinmune, sistémica, caracterizada por fibrosis, alteraciones inmunológicas y vasculares. La hipoperfusión cerebral puede ser causada por isquemia. Los trastornos cognitivos son causa importante de morbilidad. El objetivo de este estudio fue determinar la frecuencia de alteraciones en la perfusión cerebral (PC) en pacientes con ES y deterioro cognitivo (DC). Métodos: se estudiaron 88 pacientes con ES. A todos se les aplicó el Test de Montreal (TM) para evaluar el DC. A 15 pacientes con DC que cumplieron con los criterios (sin hipertensión arterial sistémica, diabetes mellitus, evento vascular cerebral, vasculitis, hipotiroidismo, depresión, sin ingesta de fármacos que interfieran con la evaluación cognitiva), se les midió la PC mediante Gamagrama Cerebral Perfusorio (GCP).Resultados: de los 88 pacientes con ES, 58 tuvieron DC con el TM. La PC se encontró disminuida en 12/15. La disminución de la PC se observó en los siguientes lóbulos (frontal en 9/15; temporal en 7/15, y parietal en 3/15. La concordancia entre el TM y GC fue 60 % para el lóbulo frontal, 46 % para el lóbulo temporal y 13 % parietal.Conclusiones: el DC es frecuente en la ES, la disminución de la PC fue más común en el lóbulo frontal, predominado en los pacientes de mayor edad y tiempo de evolución de la ES.

  18. Cerebral malaria: gamma-interferon redux

    Directory of Open Access Journals (Sweden)

    Nicholas H Hunt

    2014-08-01

    Full Text Available There are two theories that seek to explain the pathogenesis of cerebral malaria, the mechanical obstruction hypothesis and the immunopathology hypothesis. Evidence consistent with both ideas has accumulated from studies of the human disease and experimental models. Thus some combination of these concepts seems necessary to explain the very complex pattern of changes seen in cerebral malaria. The interactions between malaria parasites, erythrocytes, the cerebral microvascular endothelium, brain parenchymal cells, platelets and microparticles need to be considered. One factor that seems able to knit together much of this complexity is the cytokine interferon-gamma. In this review we consider findings from the clinical disease, in vitro models and the murine counterpart of human cerebral malaria in order to evaluate the roles played by interferon-gamma in the pathogenesis of this often fatal and debilitating condition.

  19. Research progress of cerebral small vessel disease

    Directory of Open Access Journals (Sweden)

    Jun-dong JIA

    2015-03-01

    Full Text Available Cerebral small vessel disease refers to a group of pathological processes with various etiologies that affect small arteries, arterioles, venules, and capillaries of the brain. Recently, the researches of cerebral small vessel disease have got initial progressions, and a definite diagnosis of this disease is comfirmed by biopsy. Given the pathological material is difficult to obtain, clinicians should pay more attention to the imaging features and clinical manifestations. Correct understanding of imaging and clinical manifestations contributes to the early identification of cerebral small vessel disease. Herein, an overview is provided on the present status, common imaging features, pathogenesis, clinical manifestations and treatment of cerebral small vessel disease. DOI: 10.3969/j.issn.1672-6731.2015.02.003

  20. Gamma knife radiosurgery for cerebral arteriovenous malformations.

    Science.gov (United States)

    Kemeny, A A; Radatz, M W R; Rowe, J G; Walton, L; Hampshire, A

    2004-01-01

    Since its introduction, gamma knife radiosurgery has become an important treatment modality for cerebral arteriovenous malformations. This paper is a brief overview of the technique used, of the clinical results achieved and of the experience gained in Sheffield.

  1. Cerebral cysticercosis in a cat : clinical communication

    Directory of Open Access Journals (Sweden)

    E.V. Schwan

    2002-07-01

    Full Text Available The metacestode of Taenia solium, Cysticercus cellulosae, was recovered from the brain of a cat showing central nervous clinical signs ante mortem. This is the first record of cerebral cysticercosis in a cat in South Africa.

  2. Genetics Home Reference: hereditary cerebral amyloid angiopathy

    Science.gov (United States)

    ... prognosis of a genetic condition? Genetic and Rare Diseases Information Center Frequency The prevalence of hereditary cerebral amyloid angiopathy is unknown. The Dutch type is the most common, with over 200 ...

  3. Aneurisma gigante da artéria cerebral posterior: (segmento P3 Relato de caso Giant aneurysm of the posterior cerebral artery (P3 segment: case report

    Directory of Open Access Journals (Sweden)

    Ronaldo Pereira

    1995-09-01

    Full Text Available Apresentamos caso de aneurisma gigante do segmento distal (P3 da artéria cerebral posterior. O aneurisma foi tratado microcirurgicamente pela via combinada proposta por Sano com clipagem do ramo terminal da artéria cerebral posterior próximo ao aneurisma. A paciente teve evolução pós operatória favorável, com lesão parcial e transitória do III nervo craniano. Revisão da literatura e discussão a respeito da anatomia e da abordagem cirúrgica são feitas. A raridade desta patologia justifica o relato deste caso.A rare case of giant aneurysm of the P3 segment of the posterior cerebral artery is presented. The aneurysm was acessed through a combined approach proposed by Sano and the aneurysm was treated by proximal clipping. The patient had a good postoperative recovery without any neurological deficit. The anatomy and the operative approaches are discussed and the neurosurgical literature reviewed.

  4. Wearable wireless cerebral oximeter (Conference Presentation)

    Science.gov (United States)

    Zhang, Xin; Jiang, Tianzi

    2016-03-01

    Cerebral oximeters measure continuous cerebral oxygen saturation using near-infrared spectroscopy (NIRS) technology noninvasively. It has been involved into operating room setting to monitor oxygenation within patient's brain when surgeons are concerned that a patient's levels might drop. Recently, cerebral oxygen saturation has also been related with chronic cerebral vascular insufficiency (CCVI). Patients with CCVI would be benefited if there would be a wearable system to measure their cerebral oxygen saturation in need. However, there has yet to be a wearable wireless cerebral oximeter to measure the saturation in 24 hours. So we proposed to develop the wearable wireless cerebral oximeter. The mechanism of the system follows the NIRS technology. Emitted light at wavelengths of 740nm and 860nm are sent from the light source penetrating the skull and cerebrum, and the light detector(s) receives the light not absorbed during the light pathway through the skull and cerebrum. The amount of oxygen absorbed within the brain is the difference between the amount of light sent out and received by the probe, which can be used to calculate the percentage of oxygen saturation. In the system, it has one source and four detectors. The source, located in the middle of forehead, can emit two near infrared light, 740nm and 860nm. Two detectors are arranged in one side in 2 centimeters and 3 centimeters from the source. Their measurements are used to calculate the saturation in the cerebral cortex. The system has included the rechargeable lithium battery and Bluetooth smart wireless micro-computer unit.

  5. Joubert syndrome labeled as hypotonic cerebral palsy

    OpenAIRE

    Dekair, Lubna H.; Kamel, Hussein; El-Bashir, Haitham O.

    2014-01-01

    Joubert syndrome (JS) is a rare autosomal recessive disorder with cerebellar vermis hypoplasia and complex brainstem malformation. The diagnosis of cases can be difficult as the presentation can be similar to cases of cerebral palsy. We present a case of JS in an 18-month-old girl who presented to pediatric rehabilitation with a diagnosis of hypotonic cerebral palsy and abnormal eye movements. The brain MRI confirmed the typical brain malformations.

  6. Tongue mobility in patients with cerebral palsy

    OpenAIRE

    Živković Zorica; Golubović Slavica

    2012-01-01

    Background/Aim. In children with cerebral palsy speech is a big problem. Speech of these children is more or less understandable, depending on the degree of reduced mobility of articulatory organs. Reduced mobility is affected by inability to control facial grimacing and poor muscle strength when performing targeted movements. The aim of this study was to determine the mobility of tongue in patients with cerebral palsy. Methods. The study included a sample of 34 children - patients with...

  7. Ocular problems in children with cerebral palsy

    OpenAIRE

    Esra Ayhan Tuzcu; Fatmagül Başarslan; Cahide Yılmaz; Seçil Arıca; Nilgün Üstün; Özgür İlhan; Mesut Coşkun; Uğurcan Keskin

    2012-01-01

    The aim of this study is to evaluate eye problemsin children with cerebral palsy in our region.Materials and Methods: 90 patients which was diagnosedas cerebral palsy, treated and followed up in PediatricNeurology Department of Mustafa Kemal University,were included to this study. The history was taken, anda physical examination was performed to determine theetiology of the disease and type of SP. All of the patientswere underwent a detailed ophthalmological examinationincluding visual acuity...

  8. PRETERM BIRTH ASSOCIATION WITH CEREBRAL PALSY

    OpenAIRE

    Srinivasa Rao; Vidyullatha; Subbalakshmi

    2015-01-01

    INTRODUCTION: Cerebral palsy ( CP ) is a group of permanent movement disorders that appear in early childhood. Preterm birth is the birth of baby before 37 completed weeks, a full term birth is birth at 37 to 42 weeks of gestation . AIM: To show the extent of association of preterm deliveries as a risk factor in development of cerebral palsy. MATERIALS AND METHODS: This r etrospective cohort study wa...

  9. Temperament of premature infants with cerebral palsy

    OpenAIRE

    Ryu, Hyo Jeong; Don Kim, Kyoung

    2015-01-01

    [Purpose] The purpose of this study was to examine the infant temperaments of children with cerebral palsy due to premature birth. [Subjects and Methods] Data were collected through questionnaires sent to 118 mothers of infants diagnosed with cerebral palsy due to premature birth. [Results] Different infant temperament scores were obtained according to the degrees of disability, type of palsy, birth weights, gestational age, and periods of hospitalization in an NICU; however, the differences ...

  10. Spontaneous Partial Regression of Cerebral Arteriovenous Malformation

    OpenAIRE

    Choi, Jae Ho; Shin, Ji Hoon; Cho, Seong Shik; Choi, Deuk Lin; Byun, Bark Jang; Kim, Dong Won

    2002-01-01

    Arteriovenous malformation (AVM) of the brain is one of the important pathologic conditions which cause intracerebral or subarachnoid hemorrhage, epilepsy, or chronic cerebral ischemia. The spontaneous regression of cerebral AVM is reported to be very rare and more likely to occur when the AVM is small, is accompanied by hemorrhage, and has fewer arterial feeders. We report a case of right occipital AVM which at follow-up angiography performed four years later showed near-complete spontaneous...

  11. Spontaneous partial regression of cerebral arteriovenous malformation

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jae Ho; Shin, Ji Hoon; Cho, Seong Shik; Choi, Deuk Lin; Byun, Bark Jang; Kim, Dong Won [Soonchunhyang University College of Medicine, Seoul (Korea, Republic of)

    2002-01-01

    Arteriovenous malformation (AVM) of the brain is one of the important pathologic conditions which cause intracerebral or subarachnoid hemorrhage, epilepsy, or chronic cerebral ischemia. The spontaneous regression of cerebral AVM is reported to be very rare and more likely to occur when the AVM is small, is accompanied by hemorrhage, and has fewer arterial feeders. We report a case of right occipital AVM which at follow-up angiography performed four years later showed near-complete spontaneous regression.

  12. EMBOLIA GASEOSA CEREBRAL SECUNDARIA A BIOPSIA PULMONAR

    Directory of Open Access Journals (Sweden)

    Luís Rafael Moscote Salazar

    2008-01-01

    Full Text Available A 68-year-old male patient, underwent a lung biopsy. During the procedure, the patient had sudden loss of consciousness. A simple brain computed tomography was performed. Brain images showed multiple hypodenses areas in the brain parenchyma and subarachnoid space, making the diagnosis of cerebral gaseous embolism.Our case demonstrates the importance of considering the gaseous cerebral embolism when presented sudden loss of consciousness during invasive procedures such as lung biopsy or introduction of arterial and venous catheters.

  13. Clinical Practice Guidelines for Cerebral Abscess Treatment

    Directory of Open Access Journals (Sweden)

    Danny Barrueta Reyes

    2009-03-01

    Full Text Available Clinical Practice Guidelines for Cerebral Abscess Treatment. It has been defined as a festering process caused by any germ and placed inside the cerebral parenchyma; this is a diagnostic and therapeutic challenge for surgeons and general doctors since the clinical and radiological manifestations are often imprecise. This document describes its etiological agents, clinical presentation, diagnosis and treatment. It includes assessment guidelines focused on the most important aspects to be accomplished.

  14. Cerebral microcirculation during experimental normovolaemic anaemia

    Directory of Open Access Journals (Sweden)

    Judith eBellapart

    2016-02-01

    Full Text Available Anaemia is accepted amongst critically ill patients as an alternative to elective blood transfusion. This practice has been extrapolated to head injury patients with only one study comparing the effects of mild anaemia on neurological outcome. There are no studies quantifying microcirculation during anaemia. Experimental studies suggest that anaemia leads to cerebral hypoxia and increased rates of infarction, but the lack of clinical equipoise when testing the cerebral effects of transfusion amongst critically injured patients, supports the need of experimental studies. The aim of this study was to quantify cerebral microcirculation and the potential presence of axonal damage in an experimental model exposed to normovolaemic anaemia, with the intention of describing possible limitations within management practices in critically ill patients. Under non-recovered anaesthesia, six Merino sheep were instrumented using an intracardiac transeptal catheter to inject coded microspheres into the left atrium to ensure systemic and non-chaotic distribution. Cytometric analyses quantified cerebral microcirculation at specific regions of the brain. Amyloid precursor protein staining was used as an indicator of axonal damage. Animals were exposed to normovolaemic anaemia by blood extractions from the indwelling arterial catheter with simultaneous fluid replacement through a venous central catheter. Simultaneous data recording from cerebral tissue oxygenation, intracranial pressure and cardiac output was monitored. A regression model was used to examine the effects of anaemia on microcirculation with a mixed model to control for repeated measures. Homogeneous and normal cerebral microcirculation with no evidence of axonal damage was present in all cerebral regions, with no temporal variability, concluding that acute normovolaemic anaemia does not result in short term effects on cerebral microcirculation in the ovine brain.

  15. Crossed cerebral - cerebellar diaschisis : MRI evaluation.

    Directory of Open Access Journals (Sweden)

    Chakravarty A

    2002-07-01

    Full Text Available MRI, done later in life, in two patients with infantile hemiplegia syndrome showed significant volume loss in the cerebellar hemisphere contralateral to the side of the affected cerebrum. The cerebellar volume loss seemed to correlate with the degree of volume loss in the contralateral cerebral hemisphere. These observations provide morphological evidence of the phenomenon of crossed cerebral-cerebellar diaschisis (CCD. Functional neuroimaging studies in support of the concept of CCD has been critically reviewed.

  16. Cerebral perfusion SPECT in transient ischemic attack

    Energy Technology Data Exchange (ETDEWEB)

    You, D.-L. E-mail: dlyou@mail.kfcc.org.tw; Shieh, F.-Y.; Tzen, K.-Y.; Tsai, M.-F.; Kao, P.-F

    2000-04-01

    Purpose: The purpose of our study is to evaluate the efficacy of cerebral perfusion single photon emission computerized tomography (SPECT) in patients with transient ischemic attack (TIA). Methods: Thirty-seven patients with TIA were collected for study. All patients had transient focal neurological symptoms or signs with complete recovery within 24 h after onset. The patients underwent cerebral perfusion SPECT between 6 h and 11 days after onset, with 10 cases performed within 24 h (group A), nine cases performed between 1 and 3 days (group B), 11 cases performed between 3 and 5 days (group C), and seven cases performed after more than 5 days (group D). A semi-quantitative method was used for analyzing the SPECT data, and the difference ratios between lesion side and contralateral normal side were calculated on each pair of regions of interest. Results: In total, 78.4% (29/37) of patients had reduced perfusion in the cerebral cortical regions or deep nuclei, and the regions with reduced perfusion corresponded with clinical presentations of the patients. The abnormal rate with reduced perfusion was 90.0% in group A, 77.8% in group B, 72.7% in group C and 71.4% in group D. Cross cerebellar diaschisis (CCD) was present in seven patients, and all of the primary cerebral perfusion defects of these patients were located at the territory of left or right middle cerebral artery. Conclusion: Cerebral perfusion SPECT is a potential tool to detect cerebral perfusion defects and CCD in patients with TIA. Although the perfusion defect may persist more than 5 days after onset, we suggest cerebral perfusion SPECT should be performed as soon as possible.

  17. Desajuste educativo por regiones en Colombia: ¿competencia por salarios o por puestos de trabajo?

    Directory of Open Access Journals (Sweden)

    Castillo Caicedo Maribel

    2007-08-01

    Full Text Available Este trabajo aporta una perspectiva del fenómeno de la sobreeducación,
    entendida como un desajuste por exceso, entre el nivel educativo alcanzado
    por el individuo y el exigido por el puesto de trabajo en el cual se
    desempeña; esto se debe a que existe una demanda laboral estrecha de
    puestos de trabajo para personas calificadas en Colombia. Se analizan las
    contribuciones empíricas existentes y el debate sobre las mismas; se
    examinan las teorías que permiten explicar la existencia de un desajuste
    educativo y se realiza una revisión de la literatura internacional y
    nacional sobre el tema. Adicionalmente, se plantean una serie de hipótesis
    para desarrollar un esquema que permita determinar el comportamiento
    del individuo en el fenómeno de la sobreeducación.

  18. Efecto del OLEOZON® frente a lesiones gástricas inducidas por indometacina en ratas (Effect of OLEOZON® on gastric lesions induced by indomethacin in rats

    Directory of Open Access Journals (Sweden)

    González Alvarez Ricardo

    2007-03-01

    Full Text Available El aceite de girasol ozonizado es un fármaco registrado en Cuba para el tratamiento de la giardiasis con el nombre de OLEOZON®; los ensayos clínicos realizados han demostrado que posee efectividad terapéutica comparable con un fármaco de referencia, Ornidazol. Elobjetivo del presente estudio fue determinar si el Oleozon es capaz de ejercer efecto protector contra las lesiones gástricas inducidas por la indometacina en las ratas. Estos animales fueron divididos para dos diferentes diseños experimentales con 6 grupos cada uno. En el primer experimento las ratas fueron pretratadas oralmente conOleozon (4, 12 y 24 mg/kg y 4 horas después con indometacina. En el segundo experimento las lesiones gástricas fueron inducidas por indometacina y 4 horas después tratadas con Oleozon en el mismo rango de dosis que en el anterior experimento. Las lesiones gástricas fueron evaluadas determinando el índice de ulceración. La Cimetidina fue utilizada como fármaco antiulceroso de referencia. Los resultadosdemostraron que el pretratamiento con Oleozon no impidió el daño gástrico inducido por la indometacina y no tuvo efecto citoprotector. En contraste con esto el tratamiento con Oleozon indujo reversión delas lesiones gástricas inducidas previamente por la indometacina demostrando su efecto anti-ulcerogénico en este modelo. Ozonized sunflower oil is a drug registered in Cuba for the treatment of giardiasis and it is commercially available with the name ofOleozon. The clinical trials have demonstrated that Oleozon possess therapeutic effectiveness comparable with a reference drug, Ornidazol. The aim of the present study was to determine whether Oleozon is able to exert protective effects against gastric lesionsinduced by indomethacin in rats. The animals were divided for two different experimental designs with six groups each one. In the firstexperiment the rats were pretreated with Oleozon (4, 12 y 24 mg/kg and four hours thereafter with

  19. Efecto de un programa de fisioterapia con hipoterapia sobre el equilibrio en sedestación en niños con parálisis cerebral espástica. Estudio piloto experimental

    OpenAIRE

    Rivas Carabias, Ana

    2014-01-01

    Trabajo Fin de Grado (TFG) Introducción: La parálisis cerebral es una patología que afecta a 2,5 niños nacidos vivos por cada 1000, y que consiste en un grupo de trastornos permanentes y no progresivos en el Sistema Nervioso Central, que se produce durante el desarrollo cerebral del feto o del lactante, afectando al desarrollo del movimiento y la postura y teniendo una etiología muy diversa. Se caracteriza por un retraso en el desarrollo motor, alteración de la activación de...

  20. Serial neuroradiological studies in focal cerebritis

    Energy Technology Data Exchange (ETDEWEB)

    Hatta, S. (Dept. of Neurology, Juntendo Univ. School of Medicine, Tokyo (Japan)); Mochizuki, H. (Dept. of Neurology, Juntendo Univ. School of Medicine, Tokyo (Japan)); Kuru, Y. (Dept. of Radiology, Juntendo Univ. School of Medicine, Tokyo (Japan)); Miwa, H. (Dept. of Neurology, Juntendo Univ. School of Medicine, Tokyo (Japan)); Kondo, T. (Dept. of Neurology, Juntendo Univ. School of Medicine, Tokyo (Japan)); Mori, H. (Dept. of Neurology, Juntendo Univ. School of Medicine, Tokyo (Japan)); Mizuno, Y. (Dept. of Neurology, Juntendo Univ. School of Medicine, Tokyo (Japan))

    1994-05-01

    We report serial neuroradiological studies in a patient with focal cerebritis in the head of the left caudate nucleus. On the day after the onset of symptoms, CT showed an ill-defined low density lesion. The lack of contrast enhancement appeared to be the most important finding for differentiating focal cerebritis from an encapsulated brain abscess or a tumour. MRI two days later revealed the centre of the lesion to be of slightly low intensity on T1-weighted inversion recovery (IR) images and very low intensity on T2-weighted spin echo images, which appeared to correspond to the early cerebritis stage of experimentally induced cerebritis and brain abscess. Ten days after the onset of symptoms, CT revealed a thin ring of enhancement in the head of the caudate nucleus, and a similar small ring was seen in the hypothalamus 16 days after the onset, corresponding to the late cerebritis stage. MRI nine days later revealed ill-defined high signal lesions within the involved area on the T1-weighted IR images. To our knowledge, this is the first published MRI documentation of the early cerebritis stage developing into an encapsulated brain abscess. The mechanisms underlying of these radiographic changes are discussed. (orig.)

  1. Serial neuroradiological studies in focal cerebritis

    International Nuclear Information System (INIS)

    We report serial neuroradiological studies in a patient with focal cerebritis in the head of the left caudate nucleus. On the day after the onset of symptoms, CT showed an ill-defined low density lesion. The lack of contrast enhancement appeared to be the most important finding for differentiating focal cerebritis from an encapsulated brain abscess or a tumour. MRI two days later revealed the centre of the lesion to be of slightly low intensity on T1-weighted inversion recovery (IR) images and very low intensity on T2-weighted spin echo images, which appeared to correspond to the early cerebritis stage of experimentally induced cerebritis and brain abscess. Ten days after the onset of symptoms, CT revealed a thin ring of enhancement in the head of the caudate nucleus, and a similar small ring was seen in the hypothalamus 16 days after the onset, corresponding to the late cerebritis stage. MRI nine days later revealed ill-defined high signal lesions within the involved area on the T1-weighted IR images. To our knowledge, this is the first published MRI documentation of the early cerebritis stage developing into an encapsulated brain abscess. The mechanisms underlying of these radiographic changes are discussed. (orig.)

  2. Angiographic Findings In Patients With Cerebral Aneurysm

    Directory of Open Access Journals (Sweden)

    Miri S M

    2004-09-01

    Full Text Available Background: This investigation was conducted in order to study angiographic findings in patients with cerebral aneurysm. Materials and Methods: The study conducted on 136 cases of ruptured cerebral aneurysms between 1995-2000 confirmed by means of 4-vessel cerebral angiography to get an insight to racial, geographic and environmental factors predisposing to the occurrence of subarachnoid hemorrhage and aneurysm formation. Results: The data analysis revealed the following results: 58% of the population comprised of male and 42% female with a mean age of 46 years. 89% of the aneurysms were found in the anterior circulation and 11% occurred in the posterior cerebral circulation. The most common site in both the sexes was the anterior communicating artery. 9.6% of the patients displayed two separate aneurysms. 5.2% of the aneurysms were found to be giant aneurysms and 3% of the patients had fusiform aneurysms. Conclusion: The low average age, a predilection in male population and the prevalence of aneurysms at carotid and middle cerebral artery bifurcation and the distal branches of anterior cerebral artery and a higher incidence of anterior communicating artery in women were the findings observed in this study.

  3. [Platelets, atherothrombosis, antiplatelet drugs and cerebral ischemia].

    Science.gov (United States)

    Bousser, Marie-Germaine

    2013-02-01

    Platelets play a much more important role in myocardial ischemia than in cerebral ischemia, because atherothrombosis - the underlying cause of the vast majority of myocardial infarcts - is responsible for only 25-30% of cerebral infarcts. Aspirin is the only effective antiplatelet drug for primary prevention of ischemic events, especially those affecting the heart. For secondary prevention of cerebral infarction, clopidogrel and the combination of aspirin with extended-release dipyridamole are both marginally better than aspirin alone, but aspirin remains the gold standard worldwide because of its remarkable cost/benefit/tolerability ratio. The clopidogrel-aspirin combination is to be avoided because of the risk of hemorrhage, particularly in the brain and gastrointestinal tract. Revascularization strategies and the choice of antiplatelet drugs for the acute phase of myocardial and cerebral ischemia are very different, consisting of endovascular treatment and aggressive platelet inhibition for coronary infarcts, versus intravenous thrombolysis and / or aspirin for cerebral infarcts. None of the new antiplatelet drugs used in acute coronary syndromes has so far been studied in acute cerebral ischemia. PMID:24919368

  4. Changes in mean cerebral blood flow velocity during cognitive task-induced cerebral fatigue in high performance fighter pilots

    Institute of Scientific and Technical Information of China (English)

    Yongsheng Chen

    2008-01-01

    BACKGROUND: Several studies have demonstrated that sustained cognitive tasks can induce cognitive fatigue and that the mean cerebral blood flow velocity changes in some cerebral regions during cerebral fatigue. OBJECTIVE: To dynamically monitor the changes in mean cerebral blood flow velocity in different brain regions of high performance fighter pilots during mental arithmetic tasks and consecutive performance tasks. DESIGN, TIME AND SETTING: The present neurophysiological trial, based on controlled observation, was performed at the Laboratory of Neurophysiology, Institute of Aviation Medicine, Air Force of China between January 2003 and December 2005. PARTICIPANTS: Forty-five males, high performance fighter pilots, averaging (27.6 ± 2.5) years, were recruited for this study. METHODS: The mean cerebral blood flow velocity in the anterior cerebral artery, middle cerebral artery, and posterior cerebral artery of subjects was dynamically tested using transcranial Doppler during 5- hour mental arithmetic tasks and during 5- hour consecutive performance tasks. The neurobehavioral ability index was analyzed throughout each trial according to the number of correct responses, false responses, and lost responses. Simultaneously, cerebral cognitive fatigue-induced lethargy was assessed by the Stanford Sleepiness Scale. MAIN OUTCOME MEASURES: Changes in mean cerebral blood flow velocity in the anterior cerebral artery, middle cerebral artery, and posterior cerebral artery; neurobehavioral ability index of mental arithmetic and consecutive performance tasks; Stanford Sleepiness Scale scores. RESULTS: During mental arithmetic tasks, the mean cerebral blood flow velocity in the anterior cerebral artery increased during hour 2 and decreased after hour 4. There was no significant change in mean cerebral blood flow velocity in the middle cerebral artery and posterior cerebral artery. During hour 4, cerebral cognitive fatigue was observed and, simultaneously, Stanford Sleepiness

  5. La ozonoterapia protege los túbulos proximales de la corteza renal del daño por isquemia-reperfusión. Estudio morfométrico preliminar

    Directory of Open Access Journals (Sweden)

    Enoy Leiva Pantoja

    2010-01-01

    Full Text Available La isquemia-reperfusión renal es causa de insuficiencia renal aguda, la cual presenta un elevado índice de mortalidad. Actualmente, los tratamientos empleados en la recuperación del riñón sometido a isquemia-reperfusión tienen un éxito limitado. Por tanto, se hace necesaria la búsqueda de estrategias terapéuticas efectivas que ayuden a prevenir el daño renal. La característica histopatológica más prominente de la isquemia-reperfusión renal es la lesión de los túbulos proximales corticales. El objetivo de este trabajo fue evaluar el efecto del precondicionamiento oxidativo con ozono sobre la morfología de los túbulos proximales de la corteza renal, ante el daño por isquemia-reperfusión. Se estudiaron fragmentos de corteza renal procedentes de 16 ratas, divididas en cuatro grupos: controles, dañadas por isquemia-reperfusión (60 min de isquemia seguidos por 180 min de reperfusión y dos grupos de ratas precondicionadas con ozono (0,5 y 1,1 mg/kg de peso corporal respectivamente y sometidas a isquemia-reperfusión. Las muestras se procesaron según la técnica convencional de inclusión en resina Spurr. Se realizaron cortes semifinos, que se analizaron cualitativa y cuantitativamente por Microscopia Óptica. Se identificaron los marcadores morfológicos del daño renal inducido por isquemia-reperfusión sobre los túbulos proximales renales: pérdida del ribete en cepillo, dilatación tubular, aumento de áreas y perímetros tubulares, necrosis celular y aumento de núcleos de células epiteliales en la luz tubular, relacionado con la formación de cilindros. El precondicionamiento oxidativo con ozono condujo a la recuperación de la morfología de los túbulos proximales. Al propiciar la protección de las células epiteliales de los túbulos proximales renales, la ozonoterapia podría considerarse una herramienta efectiva ante el daño por isquemia-reperfusión renal.

  6. Clonagem de canistel por estaquia

    Directory of Open Access Journals (Sweden)

    Fernando Marcelo Chiamolera

    2014-09-01

    Full Text Available O canistel é nativo do sul do México e América Central e seus frutos apresentam elevado teor de carotenoides e vitamina A. Sua propagação é feita via sementes, resultando em considerável variabilidade genética entre os indivíduos, sendo a propagação vegetativa preferível, a fim de fixar características desejáveis. Assim, o objetivo deste trabalho foi avaliar a propagação vegetativa por estaquia de ramos semi-herbáceos de canistel, em função de quatro genótipos e quatro concentrações de AIB. Foram utilizadas estacas semiherbáceas apicais, mantidas com um par de folhas, sob nebulização intermitente, por 120 dias. O delineamento experimental foi o inteiramente casualizado, em esquema fatorial 4×4 (genótipos de canistel × concentrações de AIB, com quatro repetições e dez estacas por parcela. Foram avaliados a porcentagem de sobrevivência, a retenção foliar, o enraizamento, o calejamento, o número e o comprimento médio de raízes por estaca. O genótipo PC-1 foi superior aos demais, em todas as variáveis avaliadas, com destaque para o enraizamento das estacas, superior a 60%. As concentrações de AIB (0; 1.000; 3.000 e 5.000 mg L-1 não influenciaram na sobrevivência, retenção foliar e enraizamento das estacas, mas aumentaram o número e o comprimento de raízes em relação ao tratamento-controle (sem AIB. Há diferença na capacidade de enraizamento das estacas entre os genótipos de canistel, sendo a melhor resposta obtida com PC-1. A concentração de 3.000 mg L-1 de AIB resulta em maior número e comprimento de raízes nas estacas de canistel.

  7. Once mil metros por segundo

    OpenAIRE

    2012-01-01

    Esta exposición es una ventana hacia el mundo de la Ciencia Ficción. Los sueños de escritores extraordinarios, personajes, lugares, máquinas y robots que cada día están más cerca de nuestra cotidianidad gracias a los avances de la ciencia y la tecnología hacen parte de la muestra itinerante por las sedes de la Universidad Nacional. El visitante puede recorrer los diferentes géneros que constituyen este género literario, además de conocer sus principales representantes. Así mismo se explor...

  8. Sepsis neonatal por Estreptococos Pyogenes

    OpenAIRE

    Gilberto Rodríguez-Herrera; Cinthya Ramírez-Navarro

    2009-01-01

    Se presenta el caso de un paciente masculino, recién nacido a término adecuado para la edad gestacional, quien nace por parto vaginal, con el antecedente de fiebre en la madre durante el periodo de postparto inmediato. Los padres consultan a los 2 días de vida pues le notan dificultad respiratoria, hipoactividad y rechazo a la leche materna. El paciente se interna y se aborda como una sepsis. Durante su estancia en el servicio de neonatología del Hospital Nacional de Niños asocia fallo respir...

  9. Miasis ocular por Oestrus ovis

    Directory of Open Access Journals (Sweden)

    María Beltrán F

    2006-01-01

    Full Text Available Se presentan tres casos de miasis ocular (dos adultos y un niñoprocedentes de zonas ganaderas de la provincia de Huaura,departamento de Lima,que acudieron al Hospital Regional de Huacho por presentar el ojo rojo,fotofobia, edema palpebral y sensación de cuerpo extraño;se extrajeron larvas adheridas al canto interno del ojo,las cuales se recibieron en el Instituto Nacional de Salud y fueron identificadas como Oestrus ovis .

  10. Changes in Cerebral Perfusion around the Time of Delayed Cerebral Ischemia in Subarachnoid Hemorrhage Patients

    NARCIS (Netherlands)

    Dankbaar, J. W.; de Rooij, N. K.; Smit, E. J.; Velthuis, B. K.; Frijns, C. J. M.; Rinkel, G. J. E.; van der Schaaf, I. C.

    2011-01-01

    Background: Because the pathogenesis of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is unclear, we studied cerebral perfusion at different time points around the occurrence of DCI. Methods: We prospectively enrolled 53 patients admitted to the University Medical Center Utrech

  11. Relationship between vasospasm, cerebral perfusion, and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

    NARCIS (Netherlands)

    Dankbaar, Jan W.; Rijsdijk, Mienke; van der Schaaf, Irene C.; Velthuis, Birgitta K.; Wermer, Marieke J. H.; Rinkel, Gabriel J. E.

    2009-01-01

    Vasospasm after aneurysmal subarachnoid hemorrhage (SAH) is thought to cause ischemia. To evaluate the contribution of vasospasm to delayed cerebral ischemia (DCI), we investigated the effect of vasospasm on cerebral perfusion and the relationship of vasospasm with DCI. We studied 37 consecutive SAH

  12. Cerebral infarction and cerebral salt wasting syndrome in a patient with tuberculous meningoencephalitis.

    Science.gov (United States)

    Loo, K L; Ramachandran, R; Abdullah, B J; Chow, S K; Goh, E M L; Yeap, S S

    2003-09-01

    A 38-year old female with underlying systemic lupus erythematosus was admitted with tuberculous meningoencephalitis. After an initial good response to anti-tuberculous treatment, she developed cerebral infarction and profound hyponatremia. This was due to cerebral salt wasting syndrome, which has only previously been described in 2 cases. The difficulties in diagnosis and management of this case are discussed.

  13. Cerebral oxygen extraction, oxygen consumption, and regional cerebral blood flow during the aura phase of migraine

    DEFF Research Database (Denmark)

    Friberg, L; Olesen, Jes; Lassen, N A;

    1994-01-01

    The aura phase of migraine is associated with focal blood flow changes, but it has been largely unknown whether these changes are correlated to changes in the cerebral metabolism.......The aura phase of migraine is associated with focal blood flow changes, but it has been largely unknown whether these changes are correlated to changes in the cerebral metabolism....

  14. Cerebral perfusion and cerebral ischemia in patients with symptomatic carotid artery stenosis

    NARCIS (Netherlands)

    Jongen, L.M.

    2010-01-01

    Next to thromboembolism from the atherosclerotic plaque, impaired cerebral perfusion is the main mechanism of cerebral ischemia in patients with symptomatic carotid artery stenosis. There is supporting evidence of a synergistic effect of both embolic and hemodynamic factors. An understanding of both

  15. Polioencefalomalacia experimental em bovinos induzida por toxicose por enxofre

    Directory of Open Access Journals (Sweden)

    Paulo H.J. Cunha

    2011-01-01

    Full Text Available O presente trabalho teve como objetivos avaliar os sinais clínicos, as concentrações do sulfeto de hidrogênio ruminal e as alterações anatomopatológicas associadas à intoxicação experimental por enxofre em bovinos. Foram utilizados dez bezerros mestiços leiteiros, sendo que quatro bovinos ingeriram ração sem sulfato de sódio (G1 e seis consumiram ração com sulfato de sódio (G2. Exames clínicos (temperatura retal, frequência cardíaca e respiratória e motricidade ruminal e laboratoriais (hemograma, fibrinogênio, proteína plasmática, pH do fluido ruminal, concentração do sulfeto de hidrogênio ruminal, líquido cerebrospinal e histopatológico foram realizados. A temperatura retal, frequência cardíaca, hemograma, fibrinogênio, proteína plasmática, pH do fluido ruminal e os valores do líquido cerebrospinal estavam dentro dos valores de referência para a espécie. Taquipnéia, hipomotricidade ruminal e elevados valores de sulfeto de hidrogênio ruminal foram observados nos bezerros do grupo G2. Um bezerro do grupo G2 apresentou sinais neurológicos e lesões histopatológicas de PEM. Dois animais de cada grupo foram eutanasiados. Lesões microscópicas foram observadas nos bezerros do G2. Histologicamente as alterações observadas foram necrose neuronal cortical e lesões hemorrágicas nos núcleos basais, tálamo, mesencéfalo, ponte e bulbo. O protocolo experimental constituído por uma dieta rica em carboidrato de alta fermentação, baixa quantidade de fibra efetiva e altos níveis de enxofre (0,52% ocasionou alterações clinicas e histológicas e elevadas concentrações de sulfeto de hidrogênio ruminal compatíveis com quadro de intoxicação por enxofre.

  16. Cranio-cerebral gunshot wounds

    Directory of Open Access Journals (Sweden)

    C. Majer1, G. Iacob2

    2010-11-01

    Full Text Available Cranio-cerebral gunshots wounds(CCGW are the most devastating injuriesto the central nervous system, especiallymade by high velocity bullets, the mostdevastating, severe and usually fatal type ofmissile injury to the head.Objective: To investigate and compare,using a retrospective study on five cases theclinical outcomes of CCGW. Predictors ofpoor outcome were: older age, delayedmode of transportation, low admissionCGS score with haemodynamic instability,CT visualization of diffuse brain damage,bihemispheric, multilobar injuries withlateral and midline sagittal planestrajectories made by penetrating highvelocity bullets fired from a very closerange, brain stem and ventricular injurywith intraventricular and/or subarachnoidhemorrhage, mass effect and midline shift,evidence of herniation and/or hematomas,high ICP and/or hypotension, abnormalcoagulation states on admission ordisseminated intravascular coagulation. Lessharmful effects were generated by retainedmissiles, bone fragments with CNSinfection, DAI lesions and neuronaldamages associated to cavitation, seizures.Material and methods: 5 patients (4 maleand 1 female, age ranged 22-65 years, withCCGW, during the period 2004-2009,caused by military conflict and accidentalfiring. After initial resuscitation all patientswere assessed on admission by the GlasgowComa Scale (GCS. After investigations: Xrayskull, brain CT, Angio-CT, cerebralMRI, SPECT; baseline investigations,neurological, haemodynamic andcoagulability status all patients underwentsurgical treatment following emergencyintervention. The survival, mortality andfunctional outcome were evaluated byGlasgow Outcome Scale (GOS score.Results: Referring on five cases weevaluate on a retrospective study the clinicaloutcome, imagistics, microscopic studies onneuronal and axonal damage generated bytemporary cavitation along the cerebralbullet’s track, therapeutics, as the review ofthe literature. Two patients with anadmission CGS 9 and 10

  17. Hipoglucemia inducida por carcinoma adrenal

    Directory of Open Access Journals (Sweden)

    Jimena Soutelo

    2013-08-01

    Full Text Available El carcinoma suprarrenal es una neoplasia maligna infrecuente y de mal pronóstico. La presentación clínica más común es originada por la producción hormonal excesiva, mientras que el desarrollo de hipoglucemia sintomática es excepcional. Presentamos el caso de una mujer de 37 años que ingresó al hospital por síntomas de hipoglucemias graves, hipertensión arterial, hipopotasemia y amenorrea secundaria. En el laboratorio se halló hipoglucemia con insulina inhibida y niveles de andrógenos en rango tumoral. La tomografía computarizada (TC de abdomen y pelvis mostró voluminosa formación heterogénea de aspecto sólido sin plano de clivaje con respecto al parénquima hepático e intenso realce con contraste. Luego de la extirpación de la masa retroperitoneal, evolucionó con valores de glucemia y potasemia normales, estabilizó la presión arterial y recuperó los ciclos menstruales.

  18. Estrategias educativas para alumnos con daño cerebral sobrevenido

    OpenAIRE

    Grau Rubio, Claudia

    2007-01-01

    Los síntomas de los niños afectados por un daño cerebral sobrevenido pueden ser pasajeros o permanentes, y presentar alteraciones cognitivas (percepción, atención, memoria y pensamiento), expresivas (lenguaje y motricidad), emocionales y del comportamiento y alteración en las funciones ejecutivas. Asimismo, pueden sufrir ataques de epilepsia, hidrocefalia, cefalea y fatiga crónica y tienen problemas de aprendizaje, de conducta y de adaptación social. La escuela debe hacer las adaptaciones ...

  19. Mixoma atrial esquerdo com acidente vascular cerebral isquêmico em criança

    Directory of Open Access Journals (Sweden)

    Takakura Isabela Thomaz

    1998-01-01

    Full Text Available É apresentado um caso de mixoma atrial esquerdo associado a acidente vascular cerebral embólico em paciente do sexo feminino, com oito anos de idade. Feita a exérese do tumor, a criança apresentava, dois meses após cirurgia, presença de massa septoatrial esquerda, sugerindo recidiva, mantendo-se, porém, assintomática. A revisão da literatura enfatiza a raridade e a agressividade com que este tumor acomete esta faixa etária, além de salientar baixas taxas de recidiva após sua retirada.

  20. Parálisis cerebral infantil: tóxina botulínica y fisioterapia

    OpenAIRE

    Frías González, Laura

    2014-01-01

    La Parálisis Cerebral Infantil es una encefalopatía secular con afectación predominantemente motriz, que consiste en una variada combinación de espasticidad, ataxia, distonía y otras discinesias [1]. La espasticidad es la mayor causante de discapacidad física, por lo que su tratamiento va a ser de vital importancia en los niños que la presentan. Para ello hay diferentes técnicas que podemos llevar a cabo, aunque siempre debemos tener en cuenta las características individuale...

  1. Intervención educativa: alumnos con discapacidad motora (parálisis cerebral infantil)

    OpenAIRE

    Valencia Navajas, Jesús

    2015-01-01

    La parálisis cerebral ofrece al profesional un campo de intervención amplísimo, con el fin de facilitar la tarea reeducativa en esta área. Realizo este trabajo, concentrado en distintas actividades, ideadas en algunos casos por diferentes autores, y en otros casos, diseñadas en base al ejercicio profesional. Cuando nos disponemos a reeducar disfunciones neurológicas y musculares, partimos de un diagnóstico, arriesgamos un pronóstico y aplicamos una terapia. Esta elección supone una reflexi...

  2. Guía de recursos sobre daño cerebral adquirido

    OpenAIRE

    Aranaz Tudela, Jaime

    2006-01-01

    El completo desarrollo de una guía de recursos sobre daño cerebral adquirido, formada por una base de datos y una aplicación Web para su gestión, que cumpla con todos los criterios sobre accesibilidad para personas con alguna discapacidad, constituye el eje central del presente proyecto. En el capítulo 1, se explica la introducción al proyecto, su motivación y los objetivos básicos que persigue la realización del mismo. El capítulo 2 expone la gestión inicial del proyecto, donde se explica la...

  3. Cerebral oxygen metabolism and cerebral blood flow in man during light sleep (stage 2)

    DEFF Research Database (Denmark)

    Madsen, P L; Schmidt, J F; Holm, S;

    1991-01-01

    We measured cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) during light sleep (stage 2) in 8 young healthy volunteers using the Kety-Schmidt technique with 133Xe as the inert gas. Measurements were performed during wakefulness and light sleep as verified by standard...... polysomnography. Unlike our previous study in man showing a highly significant 25% decrease in CMRO2 during deep sleep (stage 3-4) we found a modest but statistically significant decrease of 5% in CMRO2 during stage 2 sleep. Deep and light sleep are both characterized by an almost complete lack of mental activity....... They differ in respect of arousal threshold as a stronger stimulus is required to awaken a subject from deep sleep as compared to light sleep. Our results suggest that during non-rapid eye movement sleep cerebral metabolism and thereby cerebral synaptic activity is correlated to cerebral readiness rather than...

  4. The effect of herbs on cerebral energy metabolism in cerebral ischemia-reperfusion mice

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Vascular dementia is one of the most familiar types of senile dementia. Over the past few years, the research on the damage of cerebral tissues after ischemia has become a focus. The factors and mechanism of cerebral tissue damage after ischemia are very complex. The handicap of energy metabolism is regarded as the beginning factor which leads to the damage of neurons, but its dynamic changes in ischemic area and its role during the process of neuronal damage are not very clear. There are few civil reports on using 31 P nuclear magnetic resonance instrument to explore the changes of cerebral energy metabolism in intravital animals. After exploring the influence of herbs on cerebral energy metabolism in ischemia-reperfusion mice, we came to the conclusion that herbs can improve the cerebral energy metabolism in ischemia-reperfusion mice.

  5. Desarrollo de una estrategía diagnóstica por resonancia magnética multimodal para tumores cerebrales.

    OpenAIRE

    León Guijarro, José Luis

    2015-01-01

    RESUMEN Esta Tesis estudia el uso combinado de las imágenes morfológicas obtenidas en los estudios de Resonancia Magnética para el diagnóstico de los tumores cerebrales con las nuevas técnicas que incluyen a la espectroscopía, perfusión y difusión cerebral por resonancia magnética. Estas técnicas tienen valor de biomarcadores, en cuanto son cuantificables, facilitan el diagnóstico precoz del tumor cerebral, su gradación, respuesta y seguimiento tras las medidas terapéuticas empleadas. ...

  6. Preemptive Medicine for Cerebral Aneurysms

    Science.gov (United States)

    AOKI, Tomohiro; NOZAKI, Kazuhiko

    2016-01-01

    Most of cerebral aneurysms (CAs) are incidentally discovered without any neurological symptoms and the risk of rupture of CAs is relatively higher in Japanese population. The goal of treatments for patients with CAs is complete exclusion of the aneurysmal rupture risk for their lives. Since two currently available major treatments, microsurgical clipping and endovascular coiling, have inherent incompleteness to achieve cure of CAs with some considerable treatment risks, and there is no effective surgical or medical intervention to inhibit the formation of CAs in patients with ruptured and unruptured CAs, new treatment strategies with lower risk and higher efficacy should be developed to prevent the formation, growth, and rupture of CAs. Preemptive medicine for CAs should be designed to prevent or delay the onset of symptoms from CAs found in an asymptomatic state or inhibit the de novo formation of CAs, but we have no definite methods to distinguish rupture-prone aneurysms from rupture-resistant ones. Recent advancements in the research of CAs have provided us with some clues, and one of the new treatment strategies for CAs will be developed based on the findings that several inflammatory pathways may be involved in the formation, growth, and rupture of CAs. Preemptive medicine for CAs will be established with specific biomarkers and imaging modalities which can sensor the development of CAs. PMID:27053328

  7. The hip in cerebral palsy.

    Science.gov (United States)

    Bleck, E E

    1980-01-01

    Orthopedic surgery can alleviate the hip flexion, adduction, and medial rotation deformities of the hip and improve the function and appearance of gait. To accomplish this, however, careful examination and prudence in the operative procedure to avoid overdoing and overcorrecting are important. Orthopedic surgery can prevent subluxation and dislocation of the hip before the age of seven years, and consequently repetitive radiographic examinations of the hip in children who have spastic paralysis of the hip musculature should be a routine procedure. Subluxation and dislocation of the hip, when established, can be successfully treated with orthopedic surgical procedures. Physicians must keep in mind that the spastic paralysis of cerebral palsy originates in the brain, and therefore the spasticity cannot be eliminated. The best that can be done is to weaken or remove some muscles as deforming forces and to achieve compromises for continued function. The goal should be optimal independence for the child and adolescent during development, and freedom from pain with deteriorating function due to degenerative arthritis in the adult. PMID:7360505

  8. Clinical presentation of cerebral aneurysms

    International Nuclear Information System (INIS)

    Presentation of a cerebral aneurysm can be incidental, discovered at imaging obtained for unrelated causes, can occur in the occasion of imaging obtained for symptoms possibly or likely related to the presence of an unruptured aneurysm, or can occur with signs and symptoms at the time of aneurismal rupture. Most unruptured intracranial aneurysms are thought to be asymptomatic, or present with vague or non-specific symptoms like headache or dizziness. Isolated oculomotor nerve palsies, however, may typically indicate the presence of a posterior circulation aneurysm. Ruptured intracranial aneurysms are by far the most common cause of non-traumatic subarachnoid hemorrhage and represent a neurological emergency with potentially devastating consequences. Subarachnoid hemorrhage may be easily suspected in the presence of sudden and severe headache, vomiting, meningism signs, and/or altered mental status. However, failure to recognize milder and more ambiguous clinical pictures may result in a delayed or missed diagnosis. In this paper we will describe the clinical spectrum of unruptured and ruptured intracranial aneurysms by discussing both typical and uncommon clinical features emerging from the literature review. We will additionally provide the reader with descriptions of the underlying pathophysiologic mechanisms, and main diagnostic pitfalls

  9. Cerebral CT of ischaemic lesions

    Energy Technology Data Exchange (ETDEWEB)

    Aulich, A.

    1981-11-25

    The diagnosis of stroke must first be established by clinical examination. CT has proved useful for confirmation of the diagnosis and provides a global intracranial picture of morphological changes in cerebral vascular diseases. A hemorrhage can be recognized with certainty at the first CT examination as the cause of the stroke, but in the detection of a lesion due to ischemia an important role is played by the correct choice of the time of examination, and in some cases also of the check-up with contrast medium. The differential diagnosis between infarct in the acute stage and encephalitis or gliomas of low-grade malignity can be difficult. A decision can often only be made after a series of examinations. Postmalacial conditions are often difficult to differentiate from defects due to other causes, such as hemorrhage, head injury, postoperative states and after encephalitis. A knowledge of the anamnesis and the clinical findings is indispensable for CT evaluation. In assessing the prognosis before vascular surgery on the extracranial brain-supplying vessels the performance of a CT examination should be advised. A warning is given against the use of CT as a screening method.

  10. Clinical presentation of cerebral aneurysms

    Energy Technology Data Exchange (ETDEWEB)

    Cianfoni, Alessandro [Neurocentro della Svizzera Italiana, Ospedale Civico di Lugano, via Tesserete, 46, 6900 Lugano (Switzerland); Pravatà, Emanuele, E-mail: emanuele.pravata@gmail.com [Neurocentro della Svizzera Italiana, Ospedale Civico di Lugano, via Tesserete, 46, 6900 Lugano (Switzerland); De Blasi, Roberto [Neurocentro della Svizzera Italiana, Ospedale Civico di Lugano, via Tesserete, 46, 6900 Lugano (Switzerland); Tschuor, Costa Silvia [Dipartimento di Radiologia, Ospedale Civico di Lugano, via Tesserete, 46, 6900 Lugano (Switzerland); Bonaldi, Giuseppe [U.O. Neuroradiologia, Ospedali Riuniti di Bergamo, Largo Barozzi, 1, 24128 Bergamo (Italy)

    2013-10-01

    Presentation of a cerebral aneurysm can be incidental, discovered at imaging obtained for unrelated causes, can occur in the occasion of imaging obtained for symptoms possibly or likely related to the presence of an unruptured aneurysm, or can occur with signs and symptoms at the time of aneurismal rupture. Most unruptured intracranial aneurysms are thought to be asymptomatic, or present with vague or non-specific symptoms like headache or dizziness. Isolated oculomotor nerve palsies, however, may typically indicate the presence of a posterior circulation aneurysm. Ruptured intracranial aneurysms are by far the most common cause of non-traumatic subarachnoid hemorrhage and represent a neurological emergency with potentially devastating consequences. Subarachnoid hemorrhage may be easily suspected in the presence of sudden and severe headache, vomiting, meningism signs, and/or altered mental status. However, failure to recognize milder and more ambiguous clinical pictures may result in a delayed or missed diagnosis. In this paper we will describe the clinical spectrum of unruptured and ruptured intracranial aneurysms by discussing both typical and uncommon clinical features emerging from the literature review. We will additionally provide the reader with descriptions of the underlying pathophysiologic mechanisms, and main diagnostic pitfalls.

  11. Arterial tree asymmetry reduces cerebral pulsatility.

    Science.gov (United States)

    Vrselja, Zvonimir; Brkic, Hrvoje; Curic, Goran

    2015-11-01

    With each heartbeat, pressure wave (PW) propagates from aorta toward periphery. In cerebral circulation, at the level of circle of Willis (CW), four arteries and four PWs converge. Since the interference is an elemental property of the wave, PWs interfere at the level of CW. We hypothesize that the asymmetry of brain-supplying arteries (that join to form CW) creates phase difference between the four PWs that interfere at the level of CW and reduce downstream cerebral pulsatility. To best of our knowledge, the data about the sequence of PWs' arrival into the cerebral circulation is lacking. Evident imperfect bilateral symmetry of the vessels results with different path length of brain-supplying arteries, hence, PWs should arrive into the head at different times. The probabilistic calculation shows that asynchronous arrival is more probable than synchronous. The importance of PWs for the cerebral circulation is highlighted by the observation that barotrauma protection mechanisms are more influenced by the crest of PW (pulse pressure) than by the mean arterial pressure. In addition, an increased arterial pulsatility is associated with several brain pathologies. We created simple computational models of four converging arteries and found that asynchronous arrival of the PWs results with lower maximum pressure, slower rate of pressure amplification and lower downstream pulsatility. In analogy, the asynchronous arrival of the pressure waves into the cerebral circulation should decrease blood flow pulsatility and lower transmission of kinetic energy on arterial wall. We conclude that asynchronous arrival of PWs into the cerebral circulation influences cerebral hemodynamics and represents a physiological necessity. PMID:26277658

  12. PRETERM BIRTH ASSOCIATION WITH CEREBRAL PALSY

    Directory of Open Access Journals (Sweden)

    Srinivasa Rao

    2015-04-01

    Full Text Available INTRODUCTION: Cerebral palsy ( CP is a group of permanent movement disorders that appear in early childhood. Preterm birth is the birth of baby before 37 completed weeks, a full term birth is birth at 37 to 42 weeks of gestation . AIM: To show the extent of association of preterm deliveries as a risk factor in development of cerebral palsy. MATERIALS AND METHODS: This r etrospective cohort study was conducted by eliciting history from the mothers of 99 cerebral palsy children who w ere treated in Rani Chandra Mani Devi Hospital, Visakhapatnam, Andhra Pradesh, India. De tailed history was taken from the mothers of 99 cerebral palsy children who were treated in this hospital. History regarding the period of gestation at which the child was born (preterm or full term, any previous history of pre - term delivery or abortions, was obtained from the mothers and the data analyzed . RESULTS: From this study it was observed the proportional association of pre - term births to cerebral palsy is 33 out 99 i.e., about 33.33%, Of these 33 cerebral palsy children highest association being with birth at 28 wks gestation (51 %. This study also shows th at the mothers with a previous history of preterm delivery have 14.4 times higher risk of subsequent pre term delivery; those with previous history of abortions have 5.7 times risk of pre - term delivery than mothers without such history. CONCLUSION: From th is study it was concluded that the pre - term birth plays a major role as a risk factor in the development of cerebral palsy with mothers having previous pre term delivery and previous abortions adding further to this risk.

  13. Mortalidad intrahospitalaria por accidente cerebrovascular

    Directory of Open Access Journals (Sweden)

    Federico Rodríguez Lucci

    2013-08-01

    Full Text Available La mortalidad global por accidente cerebrovascular (ACV ha disminuido en las últimas tres décadas, probablemente debido a un mejor control de los factores de riesgo vascular. La mortalidad hospitalaria por ACV ha sido tradicionalmente estimada entre 6 y 14% en la mayoría de las series comunicadas. Sin embargo, los datos de ensayos clínicos recientes sugieren que esta cifra sería sustancialmente menor. Se revisaron datos de pacientes internados con diagnóstico de ACV del Banco de Datos de Stroke de FLENI y los registros institucionales de mortalidad entre los años 2000 y 2010. Los subtipos de ACV isquémicos se clasificaron según criterios TOAST y los ACV hemorrágicos en hematomas intrapanquimatosos, hemorragias subaracnoideas aneurismáticas, malformaciones arteriovenosas y otros hematomas intraparenquimatosos. Se analizaron 1514 pacientes, 1079 (71% con ACV isquémico (grandes vasos 39%, cardioembólicos 27%, lacunares 9%, etiología indeterminada 14%, otras etiologías 11% y 435 (29% con ACV hemorrágico (intraparenquimatosos 27%, hemorragia subaracnoidea 30%, malformaciones arteriovenosas 25% y otros hematomas espontáneos 18%. Se registraron 38 muertes intrahospitalarias (17 ACV isquémicos y 21 ACV hemorrágicos, representando una mortalidad global del 2.5% (1.7% en ACV isquémicos y 4.8% en ACV hemorrágicos. No se registraron muertes asociadas al uso de fibrinolíticos endovenosos. La mortalidad intrahospitalaria en pacientes con ACV isquémico y hemorrágico en nuestro centro fue baja. El manejo en un centro dedicado a las enfermedades neurológicas y el enfoque multidisciplinario por personal médico y no médico entrenado en el cuidado de la enfermedad cerebrovascular podrían explicar, al menos en parte, estos resultados.

  14. Regional Cerebral Perfusion in Progressive Supranuclear Palsy

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Won Yong; Lee, Ki Hyeong; Yoon, Byung Woo; Lee, Sang Bok; Jeon, Beom S. [Samsung Medical Center, Seoul (Korea, Republic of); Lee, Kyung Han; Lee, Myung Chul [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1996-03-15

    Progressive supranuclear palsy (PSP) is a Parkinson-plus syndrome characterized clinically by supranuclear ophthalmoplegia, pseudobulbar palsy, axial rigidity, bradykinesia, postural instability and dementia. Presence of dementia and lack of cortical histopathology suggest the derangement of cortical function by pathological changes in subcortical structures in PSP, which is supported by the pattern of behavioral changes and measurement of brain metabolism using positron emission tomography. This study was done to examine whether there are specific changes of regional cerebral perfusion in PSP and whether there is a correlation between severity of motor abnormaility and degree of changes in cerebral perfusion. We measured regional cerebral perfusion indices in 5 cortical and 2 subcortical areas in 6 patients with a clinical diagnosis of PSP and 6 healthy age and sex matched controls using Tc-99m-HMPAO SPECT. Compared with age and sex matched controls, only superior frontal regional perfusion index was significantly decreased in PSP (p<0.05). There was no correlation between the severity of the motor abnormality and any of the regional cerebral perfusion indices (p>0.05). We affirm the previous reports that perfusion in superior frontal cortex is decreased in PSP. Based on our results that there was no correlation between severity of motor abnormality and cerebral perfusion in the superior frontal cortex, nonmotoric symptoms including dementia needs to be looked at whether there is a correlation with the perfusion abnormality in superior frontal cortex

  15. Cerebral Air Embolism from Angioinvasive Cavitary Aspergillosis

    Directory of Open Access Journals (Sweden)

    Chen Lin

    2014-01-01

    Full Text Available Background. Nontraumatic cerebral air embolism cases are rare. We report a case of an air embolism resulting in cerebral infarction related to angioinvasive cavitary aspergillosis. To our knowledge, there have been no previous reports associating these two conditions together. Case Presentation. A 32-year-old female was admitted for treatment of acute lymphoblastic leukemia (ALL. Her hospital course was complicated by pulmonary aspergillosis. On hospital day 55, she acutely developed severe global aphasia with right hemiplegia. A CT and CT-angiogram of her head and neck were obtained demonstrating intravascular air emboli within the left middle cerebral artery (MCA branches. She was emergently taken for hyperbaric oxygen therapy (HBOT. Evaluation for origin of the air embolus revealed an air focus along the left lower pulmonary vein. Over the course of 48 hours, her symptoms significantly improved. Conclusion. This unique case details an immunocompromised patient with pulmonary aspergillosis cavitary lesions that invaded into a pulmonary vein and caused a cerebral air embolism. With cerebral air embolisms, the acute treatment option differs from the typical ischemic stroke pathway and the provider should consider emergent HBOT. This case highlights the importance of considering atypical causes of acute ischemic stroke.

  16. Time-varying modeling of cerebral hemodynamics.

    Science.gov (United States)

    Marmarelis, Vasilis Z; Shin, Dae C; Orme, Melissa; Rong Zhang

    2014-03-01

    The scientific and clinical importance of cerebral hemodynamics has generated considerable interest in their quantitative understanding via computational modeling. In particular, two aspects of cerebral hemodynamics, cerebral flow autoregulation (CFA) and CO2 vasomotor reactivity (CVR), have attracted much attention because they are implicated in many important clinical conditions and pathologies (orthostatic intolerance, syncope, hypertension, stroke, vascular dementia, mild cognitive impairment, Alzheimer's disease, and other neurodegenerative diseases with cerebrovascular components). Both CFA and CVR are dynamic physiological processes by which cerebral blood flow is regulated in response to fluctuations in cerebral perfusion pressure and blood CO2 tension. Several modeling studies to date have analyzed beat-to-beat hemodynamic data in order to advance our quantitative understanding of CFA-CVR dynamics. A confounding factor in these studies is the fact that the dynamics of the CFA-CVR processes appear to vary with time (i.e., changes in cerebrovascular characteristics) due to neural, endocrine, and metabolic effects. This paper seeks to address this issue by tracking the changes in linear time-invariant models obtained from short successive segments of data from ten healthy human subjects. The results suggest that systemic variations exist but have stationary statistics and, therefore, the use of time-invariant modeling yields "time-averaged models" of physiological and clinical utility.

  17. Gastrostomy tube feeding of children with cerebral palsy

    DEFF Research Database (Denmark)

    Dahlseng, Magnus O; Andersen, Guro L; DA Graca Andrada, Maria;

    2012-01-01

    To compare the prevalence of gastrostomy tube feeding (GTF) of children with cerebral palsy (CP) in six European countries.......To compare the prevalence of gastrostomy tube feeding (GTF) of children with cerebral palsy (CP) in six European countries....

  18. Cerebral near infrared spectroscopy oximetry in extremely preterm infants

    DEFF Research Database (Denmark)

    Hyttel-Sørensen, Simon; Pellicer, Adelina; Alderliesten, Thomas;

    2015-01-01

    OBJECTIVE: To determine if it is possible to stabilise the cerebral oxygenation of extremely preterm infants monitored by cerebral near infrared spectroscopy (NIRS) oximetry. DESIGN: Phase II randomised, single blinded, parallel clinical trial. SETTING: Eight tertiary neonatal intensive care units...

  19. Descifrando el ruido del cerebro: Actividad cerebral espontánea

    Directory of Open Access Journals (Sweden)

    Carlos González-García

    2014-01-01

    Full Text Available La actividad basal del cerebro ha sido conceptualizada tradicionalmente como “ruido”. Sin embargo, el avance en los métodos de análisis de neuroimagen ha permitido descifrar patrones coherentes de actividad en este estado de ‘reposo’. Estos patrones, lejos de ser aleatorios, parecen corresponderse en parte con los sistemas cerebrales clásicos, lo que sugiere que nos encontramos ante un funcionamiento ‘por defecto’ de distintas redes cerebrales. Esta Función Cerebral por Defecto facilitaría nuestra adaptación al medio mediante una constante predicción y sincronización con el mismo.

  20. Fatores associados a perfusão cerebral anormal em dependentes de cocaína Factors related to abnormal brain perfusion in cocaine addicts

    Directory of Open Access Journals (Sweden)

    Dartiu X da Silveira

    2001-03-01

    Full Text Available OBJETIVO: Avaliar a relação entre o padrão de uso da cocaína e a perfusão cerebral de dependentes da substância. MÉTODOS: Estudou-se uma amostra de 30 dependentes de cocaína por meio de tomografia computadorizada por emissão de fóton único (single photon emission computed tomography - SPECT com hexametil-propileno-amina-oxima, marcada com tecnécio 99 m (99 m-Tc-HMPAO, e comparou-se o padrão de perfusão cerebral com o padrão de consumo da droga. RESULTADOS: Dos dependentes, 80% apresentaram alterações de perfusão cerebral, focais ou difusas, com grau de intensidade variável. Não foram observadas diferenças de perfusão cerebral entre usuários de crack e usuários de cloridrato de cocaína. As alterações tomográficas tampouco permitiram distinguir os dependentes em abstinência dos dependentes na vigência do uso. Não foi possível evidenciar associação entre o relato da quantidade diária de droga utilizada e a perfusão cerebral dos pacientes. Entretanto, foi observada correlação entre o número de meses durante os quais os pacientes consumiram droga e o grau de comprometimento da perfusão cerebral (coeficiente de correlação de Spearman: r=0,45, pOBJECTIVE: To evaluate the relationship between the pattern of cocaine use and cerebral perfusion among cocaine addicts. METHOD: A sample of 30 cocaine addicts was studied using 99 m-Tc-HMPAO SPECT (single photon emission computed tomography with injection of 99 m-Tc-hexametilpropilenoamina-oxime. Their cerebral perfusion pattern was then compared with their pattern of cocaine use. RESULTS: Eighty percent of the sample presented some degree of impairment in brain perfusion, either focal or diffuse. There was no difference between sniffers and crack smokers regarding their perfusion patterns. No relationship could be established between the severity of SPECT abnormalities and the amount of drug consumption or period of abstinence. However, length of cocaine use did

  1. Una plataforma MEMS para la medición in-situ y en tiempo real de la tensión/esfuerzo inducido electroquímicamente en el electrodo de una bateria de litio-ion

    OpenAIRE

    Barón, Sergio D.

    2015-01-01

    En este trabajo se reporta la primera demostración exitosa de las capacidades de sensado de una plataforma MEMS para la caracterización in-situ de los procesos de expansión/contracción reversible inducida electroquímicamente en electrodos de baterías de litio-ion (LIB). La plataforma consiste en un arreglo de membranas flexibles que cambian su forma dinámicamente debido al intercalado/expansión y extracción/contracción de litio. El cambio de curvatura de la membrana se mide por el principio d...

  2. INFLUENCE OF DIFFERENT NEEDLE-RETAINING DURATION ON CEREBRAL HEMODYNAMICS OF CEREBRAL PARALYSIS CHILDREN

    Institute of Scientific and Technical Information of China (English)

    袁青; 王琴玉; 冯健强; 张壮涛; 陈雪云; 靳瑞

    2004-01-01

    Objective: To investigate the effects of different needle-retaining duration on cerebral hemodynamics in cerebral paralysis (CP) children.Methods: A total of 20 cases of CP children were subjected into this study.Changes of systolic peak value (Vs), blood flow velocity at the end-diastolic phase (Ved), mean velocity (Vm), pulsation index (PI) and resistance index (RI) of the cerebral hemodynamics before and after performing JIN's Three-Needling Therapy with the needles retained for 30 min (group A) and 5 min (group B) were observed by using transcranial Doppler ultrasonography (TCD).Results: After acupuncture, the blood flow in the middle cerebral artery (MCA), anterior cerebral artery (ACA) and posterior cerebral artery (PCA) was accelerated, and the resistance of blood vessels decreased.The effect of needle-retaining-30 min was better than that of needle-retaining-5 min.Conclusion: In treating cerebral paralysis by using JIN's Three-Needling Therapy, sufficient stimulation provided by needle remaining is an important factor for achieving satisfactory therapeutic effects.

  3. Morfometría de la estría vascular y el órgano de Corti ante el daño por kanamicina

    Directory of Open Access Journals (Sweden)

    Sandra Rodríguez-Salgueiro

    2010-01-01

    Full Text Available Las alteraciones morfológicas que inducen los aminoglucósidos en la estría vascular han sido muy poco estudiadas hasta el momento. Esta estructura no sensorial desempeña un papel importante en la audición, al ser la responsable de la generación del potencial endococlear necesario para el funcionamiento de las células ciliadas ubicadas en el órgano de Corti. El objetivo de este trabajo fue estudiar los cambios temporales inducidos por kanamicina sobre las áreas de la estría vascular y del órgano de Corti. Se estudiaron cócleas de 17 ratas Wistar adultas sanas y sordas de 4, 8 y 16 semanas de sordera. La sordera se indujo por inyecciones intraperitoneales de kanamicina y furosemida. Los cortes histológicos se estudiaron por Microscopia Óptica de Alta Resolución, inclusión en resina Spurr, cortes semifinos en el plano horizontal y tinción con azul de Stevenel. Se midieron las áreas de la estría vascular y del órgano de Corti en las regiones apical, medial y basal de la cóclea. El tratamiento ototóxico provocó disminución de las áreas del órgano de Corti y de la estría vascular con respecto al grupo control. La disminución del área del órgano de Corti se observó en todos los grupos de animales sordos. El área del órgano de Corti fue menor a medida que aumentó el tiempo de sordera. Se detectó disminución del área de la estría vascular solo a las ocho y dieciséis semanas de sordera. La base de la cóclea fue la región más afectada, con disminución significativa de las dos áreas en todos los grupos de animales sordos. En la octava semana de sordera se dañaron las dos áreas en todas las regiones cocleares. De acuerdo con resultados previos de este grupo de trabajo, es también en la octava semana cuando se hace significativa la disminución de la densidad neuronal del ganglio espiral.

  4. Cerebritis: An unusual complication of Klebsiella pneumoniae

    OpenAIRE

    Majumdar Mainak; Simes David; Prabha Ramesh

    2009-01-01

    Cerebritis is part of a continuum of brain infection and is difficult to diagnose. Cerebritis caused by Klebsiella in immunocompetent adults without predisposing factors such as neurosurgery or penetrating brain injury has not been reported before. We report a case of Klebsiella cerebritis in an adult patient with a proven extracranial focus of infection. We suggest considering cerebritis as a differential diagnosis for altered level of consciousness in patients of severe sepsis, even if ...

  5. Cerebral vascular effects of hypovolemia and dopamine infusions

    DEFF Research Database (Denmark)

    Holst Hahn, Gitte; Heiring, Christian; Pryds, Ole;

    2012-01-01

    Despite widespread use, effects of volume boluses and dopamine in hypotensive newborn infants remain controversial. We aimed to elucidate if hypovolemia alone impairs cerebral autoregulation (CA) and if dopamine affects cerebral vasculature.......Despite widespread use, effects of volume boluses and dopamine in hypotensive newborn infants remain controversial. We aimed to elucidate if hypovolemia alone impairs cerebral autoregulation (CA) and if dopamine affects cerebral vasculature....

  6. Magnetic resonance spectroscopy and imaging in cerebral ischemia

    International Nuclear Information System (INIS)

    In-vivo proton and phosphorus magnetic resonance spectroscopy was used to detect changes in cerebral metabolism during ischemia and other types of metabolic stress. Magnetic resonance imaging was performed in an animal model to observe morphological alterations during focal cerebral ischemia. Spectroscopy was performed in animal models with global ischemia, in volunteers during hyperventilation and pharmaco-logically altered cerebral perfusion, and in patients with acute and prolonged focal cerebral ischemia. (author). 396 refs.; 44 figs.; 14 tabs

  7. An Adult Case of Diabetic Ketoacidosis Presenting with Cerebral Edema

    OpenAIRE

    Barış Akıncı; Abdurrahman Çömlekçi; Serkan Yener; Süleyman Men

    2009-01-01

    Cerebral edema is a life-threatening complication of diabetic ketoacidosis (DKA) which may predominantly develop in pediatric cases during the management of DKA.. Symptomatic cerebral edema in children is rarely detected at admission, before initiation of the treatment. Cerebral edema associated with DKA is extremely rare in adults. Here, we report an adult patient with DKA who presented with symptomatic cerebral edema. Turk Jem 2009; 13: 16-8

  8. Dabigatran como posibilidad terapéutica en el síndrome de trombocitopenia inducida por heparina tipo II Dabigatran as a therapeutic possibility in heparin-induced thrombocytopenia type II

    Directory of Open Access Journals (Sweden)

    F.J. Anniccherico

    2012-12-01

    Full Text Available El síndrome de trombocitopenia inducido por heparina (HIT con una incidencia del 0,2-0,5 % en pacientes expuestos a heparina durante más de 4 días, es producido por una alteración inmune con formación de anticuerpos frente al complejo heparina-factor 4 plaquetario, que presenta un amplio espectro de manifestaciones clínicas: siendo la trombocitopenia, los fenómenos trombóticos arteriales/venosos y la necrosis cutánea los más frecuentes. Hasta el momento actual, lepirudina, recientemente suspendida y argatroban (inhibidores directos de la trombina son los fármacos aprobados y habitualmente usados en el tratamiento, suministrados de forma parenteral. El dabigatran, un nuevo fármaco anticoagulante, inhibidor directo y reversible de la trombina teóricamente podría ser un fármaco empleado en el tratamiento del HIT. Según la bibliografía consultada presentamos el primer caso de HIT tratada con dabigatran en la literatura médica.The syndrome of heparin-induced thrombocytopenia (HIT, with an incidence of 0.2-0.5% in patients exposed to heparin for more than 4 days, is produced by an immune alteration with the formation of antibodies against the heparin platelet factor 4 complex. It presents a wide spectrum of clinical manifestations, the most frequent of which are thrombocytopenia, thrombotic arterial-venous phenomena, and cutaneous necrosis. Up to the present, lepiridin, recently suspended, and argatroban (direct thrombin inhibitors have been the approved medicines normally used in treatment, administered in parenteral form. Dabigatran, a new anticoagulant medicine that is a direct and reversible thrombin inhibitor, could theoretically be a medicine employed in treating HIT. According to the bibliography consulted we are presenting the first case of HIT treated with dabigatran in the medical literature.

  9. Relationship between cerebral sodium-glucose transporter and hyperglycemia in cerebral ischemia.

    Science.gov (United States)

    Yamazaki, Yui; Harada, Shinichi; Tokuyama, Shogo

    2015-09-14

    Post-ischemic hyperglycemia exacerbates the development of cerebral ischemia. To elucidate this exacerbation mechanism, we focused on sodium-glucose transporter (SGLT) as a mediator that lead hyperglycemia to cerebral ischemia. SGLT transport glucose into the cell, together with sodium ion, using the sodium concentration gradient. We have previously reported that suppression of cerebral SGLT ameliorates cerebral ischemic neuronal damage. However, detail relationship cerebral between SGLT and post-ischemic hyperglycemia remain incompletely defined. Therefore, we examined the involvement of cerebral SGLT on cerebral ischemic neuronal damage with or without hyperglycemic condition. Cell survival rate of primary cultured neurons was assessed by biochemical assay. A mouse model of focal ischemia was generated using a middle cerebral artery occlusion (MCAO). Neuronal damage was assessed with histological and behavioral analyses. Concomitant hydrogen peroxide/glucose treatment exacerbated hydrogen peroxide alone-induced cell death. Although a SGLT family-specific inhibitor, phlorizin had no effect on developed hydrogen peroxide alone-induced cell death, it suppressed cell death induced by concomitant hydrogen peroxide/glucose treatment. α-MG induced a concentration-dependent and significant decrease in neuronal survival. PHZ administered on immediately after reperfusion had no effect, but PHZ given at 6h after reperfusion had an effect. Our in vitro study indicates that SGLT is not involved in neuronal cell death in non-hyperglycemic condition. We have already reported that post-ischemic hyperglycemia begins to develop at 6h after MCAO. Therefore, current our in vivo study show post-ischemic hyperglycemic condition may be necessary for the SGLT-mediated exacerbation of cerebral ischemic neuronal damage.

  10. Relationship between cerebral sodium-glucose transporter and hyperglycemia in cerebral ischemia.

    Science.gov (United States)

    Yamazaki, Yui; Harada, Shinichi; Tokuyama, Shogo

    2015-09-14

    Post-ischemic hyperglycemia exacerbates the development of cerebral ischemia. To elucidate this exacerbation mechanism, we focused on sodium-glucose transporter (SGLT) as a mediator that lead hyperglycemia to cerebral ischemia. SGLT transport glucose into the cell, together with sodium ion, using the sodium concentration gradient. We have previously reported that suppression of cerebral SGLT ameliorates cerebral ischemic neuronal damage. However, detail relationship cerebral between SGLT and post-ischemic hyperglycemia remain incompletely defined. Therefore, we examined the involvement of cerebral SGLT on cerebral ischemic neuronal damage with or without hyperglycemic condition. Cell survival rate of primary cultured neurons was assessed by biochemical assay. A mouse model of focal ischemia was generated using a middle cerebral artery occlusion (MCAO). Neuronal damage was assessed with histological and behavioral analyses. Concomitant hydrogen peroxide/glucose treatment exacerbated hydrogen peroxide alone-induced cell death. Although a SGLT family-specific inhibitor, phlorizin had no effect on developed hydrogen peroxide alone-induced cell death, it suppressed cell death induced by concomitant hydrogen peroxide/glucose treatment. α-MG induced a concentration-dependent and significant decrease in neuronal survival. PHZ administered on immediately after reperfusion had no effect, but PHZ given at 6h after reperfusion had an effect. Our in vitro study indicates that SGLT is not involved in neuronal cell death in non-hyperglycemic condition. We have already reported that post-ischemic hyperglycemia begins to develop at 6h after MCAO. Therefore, current our in vivo study show post-ischemic hyperglycemic condition may be necessary for the SGLT-mediated exacerbation of cerebral ischemic neuronal damage. PMID:26254165

  11. Anormalidades de fluxo sangüíneo cerebral em indivíduos dependentes de cocaína Cerebral blood flow abnormalities in cocaine dependent subjects

    Directory of Open Access Journals (Sweden)

    Sergio Nicastri

    2000-06-01

    Full Text Available INTRODUÇÃO: Nos últimos anos, tem havido relatos de anormalidades do fluxo sanguíneo cerebral em indivíduos com o abuso de cocaína, detectadas por meio de tomografia computadorizada por emissão de fóton único (SPECT. Esse padrão anormal de perfusão cerebral tem sido associado a prejuízos cognitivos mas não a alterações observáveis por meio de exames de neuroimagem estrutural. Um problema envolvendo a maioria dos trabalhos publicados sobre esse tema é a inclusão de um grande número de usuários de heroína nas amostras estudadas. Essa outra droga também parece afetar o padrão de perfusão cerebral, particularmente durante estados de abstinência. MÉTODOS: Quatorze pacientes dependentes de cocaína (nenhum com uso de opióides e 14 voluntários normais (grupo controle foram submetidos a exames de SPECT com dímero de etil-cisteína marcado com tecnécio-99m. A análise dos exames de SPECT foi realizada por meio de análise visual qualitativa das imagens obtidas (procedimento padrão na prática clínica, realizada por um radiologista não informado sobre o diagnóstico dos indivíduos avaliados. RESULTADOS: A análise visual revelou um padrão sugestivo de irregularidades do fluxo sangüíneo cerebral em nove pacientes, mas em apenas dois controles (p = 0,018; teste exato de Fisher bicaudal. CONCLUSÕES: Anormalidades de circulação cerebral podem ter relação com prejuízos cognitivos relatados em populações de dependentes de cocaína. Embora déficits de perfusão cerebral associados ao uso de cocaína possam ser irreversíveis, têm surgido relatos na literatura de tratamentos para essas anormalidades de fluxo sangüíneo. Alterações de fluxo sangüíneo cerebral associadas à dependência de cocaína ocorrem mesmo na ausência de abuso ou dependência de opióides.INTRODUCTION: In the last years, there have been reports of abnormalities in brain blood flow of cocaine abusers, detected by single photon computed

  12. Neurociências, neurocultura e autoajuda cerebral

    Directory of Open Access Journals (Sweden)

    Francisco Ortega

    2009-12-01

    Full Text Available Este artigo pretende analisar o fenômeno denominado de neuroascese, ou autoajuda cerebral no contexto do crescente impacto das neurociências e do surgimento da neurocultura e do sujeito cerebral. Para tanto, é importante compreender o âmbito sóciocultural mais amplo no qual a neuroascese se insere e que corresponde ao que vem se chamando de 'cultura somática' ou, mais especificamente, de biossociabilidade. O objetivo do artigo é explorar como uma forma de subjetividade reducionista, o sujeito cerebral, dá lugar à aparição de práticas de si cerebrais, isto é, práticas de como agir sobre o cérebro para maximizar a sua performance, que levam a formação de novas formas de sociabilidade.

  13. Renovascular hypertension causes cerebral vascular remodeling

    Institute of Scientific and Technical Information of China (English)

    Yamei Tang; Xiangpen Li; Yi Li; Qingyu Shen; Xiaoming Rong; Ruxun Huang; Ying Peng

    2011-01-01

    Renovascular hypertensive rats (RHRs) were developed using the 2-kidney, 2-clip method. All RHRs at 10 weeks displayed high permeability of the cerebral surface blood vessels. Vascular casts of the RHRs showed that the vascular network was sparse. The arterioles of the RHRs at 10 weeks had smaller lumen diameters, but thicker vessel walls with hyalinosis formation compared with control animals. The endothelial cell membrane appeared damaged, and microthrombus formed. After ischemia, the infarction size was larger in RHRs than in control animals. These results suggest that cerebral arterioles in RHRs underwent structural remodeling. High blood pressure may aggravate the severity of brain injury in cerebral ischemia and affect the recovery of ischemia.

  14. Neuropsychological Effects of Cerebral Amyloid Angiopathy.

    Science.gov (United States)

    Schrag, Matthew; Kirshner, Howard

    2016-08-01

    Cerebral amyloid angiopathy is a condition of the cerebral arterioles and to a lesser extent capillaries and veins, wherein beta-amyloid is deposited. In arterioles, this preferentially targets vascular smooth muscle cells and in the later stages undermines the stability of the vessel. This condition is frequently comorbid with Alzheimer's disease and its role in cognitive impairment and dementia is a topic of considerable recent research. This article reviews recent literature which confirms that CAA independently contributes to cognitive impairment by potentiating the neurodegeneration of Alzheimer's disease, by predisposing to microhemorrhagic and microischemic injury to the brain parenchyma, and by interfering with the autoregulation of CNS blood flow. In this review, we discuss the clinical presentation of cerebral amyloid angiopathy, with a focus on the neuropsychological manifestations of this vasculopathy. PMID:27357378

  15. [Transcranial electrostimulation in chronic cerebral vascular insufficiency].

    Science.gov (United States)

    Voropaev, A A; Mochalov, A D

    2006-01-01

    The method of transcranial electrostimulation (TCES) has been used for treatment of 68 patients with chronic cerebral vascular insufficiency, stages I and II. A treatment course included 7 daily procedures. The influence of TCES was evaluated clinically, by EEG, transcranial ultrasonic Doppler study and hemodynamic indices in arteries and veins as well as by expression of trait and state anxiety. All the parameters were compared to those of the control group which was treated using conventional methods. TCES resulted in normalization of cerebral vascular reactivity, a decrease of venous circulation disturbances, positive influence on cerebral blood flow and EEG parameters, that corresponded to global improvement of the patients' state, regress of cephalgic syndrome and reduction of trait and state anxiety. The method is simple and safety and can be recommended for wide application including outpatient setting.

  16. [Does cerebral salt wasting syndrome exist?].

    Science.gov (United States)

    Leblanc, P-E; Cheisson, G; Geeraerts, T; Tazarourte, K; Duranteau, J; Vigué, B

    2007-11-01

    Increased natriuresis is a frequent situation after subarachnoid haemorrhage (SAH). It may be responsible for hyponatremia, which can be dangerous in case of severe hypo-osmolarity or hypovolemia. Inappropriate secretion of antidiuretic hormone or cerebral salt wasting syndrome (CSWS) have been incriminated for hyponatremia after SAH, but it remains difficult to distinguish between both syndromes. There are many explanations for increased natriuresis after SAH, depending on the level of blood pressure, the volemia, and the presence or not of natriuretic peptides. The cerebral insult and the treatments, which are done to fight against elevated intracranial pressure or vasospasm, can modify any of these parameters. So it appears that the word "cerebral" in CSWS is probably not a good term and it would be better to talk about appropriate or non-appropriate natriuretic response. Corticoïds or urea can be useful for controlling hypernatriuresis.

  17. Computerized tomographic evaluation of cerebral cysticercosis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bo Young; Lee, Mi Sook; Jeon, Doo Sung; Kim, Hong Soo; Rhee, Hak Song [Precbyterian Medical Center, Chonju (Korea, Republic of)

    1988-08-15

    Cerebral cysticercosis, unfortunately frequent in Korea, is a parastic disease in which man serve as the intermediate host of taenia solium. The larvae have a predilection for the central nervous system and can cause a variety of neurologic symptoms. The authors reviewed 19 cases of surgically proven cerebral cysticercosis and following results were obtained. 1. The most frequent age distribution was 5th and 6th decade and male to female ratio was 14:5. 2. The most frevalent involving site was cerebral parenchyme and following by ventricles. 3. Clinical manifestations were symtom and sign of increased ICP, seizure and focal neurological dificit. 4. It was assumed that computerized tomography was the procedure of choice for the diagnosis of these parasitic brain disease.

  18. Computerized tomographic evaluation of cerebral cysticercosis

    International Nuclear Information System (INIS)

    Cerebral cysticercosis, unfortunately frequent in Korea, is a parastic disease in which man serve as the intermediate host of taenia solium. The larvae have a predilection for the central nervous system and can cause a variety of neurologic symptoms. The authors reviewed 19 cases of surgically proven cerebral cysticercosis and following results were obtained. 1. The most frequent age distribution was 5th and 6th decade and male to female ratio was 14:5. 2. The most frevalent involving site was cerebral parenchyme and following by ventricles. 3. Clinical manifestations were symtom and sign of increased ICP, seizure and focal neurological dificit. 4. It was assumed that computerized tomography was the procedure of choice for the diagnosis of these parasitic brain disease.

  19. Clinical significance of urine ferritin in patients with cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    周慧

    2013-01-01

    Objective To find an indicator in urine to assist diagnosis of cerebral infarction,we investigated the changes of urine ferritin in patients with cerebral infarction.Methods Collected serum from 30 healthy volunteers and 53 patients with cerebral infarction (CI) ,with ratio ofmales to females

  20. Radiologic manifestations of focal cerebral hyperemia in acute stroke

    DEFF Research Database (Denmark)

    Olsen, T S; Skriver, E B; Herning, M

    1991-01-01

    In 16 acute stroke patients with focal cerebral hyperemia angiography and regional cerebral blood flow (rCBF) were studied 1 to 4 days post stroke. CT was performed twice with and without contrast enhancement 3 +/- 1 days and 16 +/- 4 days post stroke. Angiographic evidence of focal cerebral hype...

  1. Cerebral ischaemia after repair of coarctation of the aorta.

    Science.gov (United States)

    Gogou, Maria; Keivanidou, Anastasia; Giannopoulos, Andreas

    2015-04-01

    A 9-year-old boy, with a history of repair of severe coarctation of the aorta through balloon angioplasty 2 weeks ago, presented in the emergency paediatric department with symptoms consistent with transient cerebral ischaemia. MRI revealed an area of cerebral infarction in the right frontal lobe. Causes of cerebral ischaemia after aortic coarctation repair are briefly discussed.

  2. MRI findings and differential diagnosis in children with cerebral paragonimiasis

    Directory of Open Access Journals (Sweden)

    Zhen Zeng

    2016-06-01

    Conclusions: The clinical manifestations of cerebral paragonimiasis are nonspecific in children while the MRI findings of cerebral paragonimiasis are characteristic, including irregular hemorrhage, ring-like enhancement and disproportionately large areas of surrounding edema. Brain MRI plays an important role in the diagnosis of cerebral paragonimiasis in children.

  3. Recirculation usually precedes malignant edema in middle cerebral artery infarcts

    DEFF Research Database (Denmark)

    Nielsen, T H; Ståhl, N; Schalén, W;

    2012-01-01

    In patients with large middle cerebral artery (MCA) infarcts, maximum brain swelling leading to cerebral herniation and death usually occurs 2-5 days after onset of stroke. The study aimed at exploring the pattern of compounds related to cerebral energy metabolism in infarcted brain tissue....

  4. Effect of labetalol on cerebral blood flow and middle cerebral arterial flow velocity in healthy volunteers

    DEFF Research Database (Denmark)

    Schroeder, T; Schierbeck, Jens; Howardy, P;

    1991-01-01

    The effect of labetalol, a combined alpha- and beta-adrenoceptor antagonist, on the cerebral circulation was investigated in 7 normotensive subjects. Cerebral blood flow (CBF) was measured with the intravenous 133Xe method and mean flow velocity (Vmean) in the middle cerebral artery was determined...... using transcranial Doppler (TCD) ultrasound. Examination was performed before and then 15, 60 and 120 min after 0.75 mg/kg i.v. labetalol. Reactivity to inhalation of 5% CO2 in air was studied before, and again 90 min after labetalol administration. Neither CBF nor Vmean changed following labetalol...

  5. THE EFFECT OF ANISODAMINE ON CEREBRAL RESUSCITATION OF RATS IN ACUTE CEREBRAL ISCHEMIA FROM CARDIAC ARREST

    Institute of Scientific and Technical Information of China (English)

    彭新琦; 曹苏谊; 可君

    1995-01-01

    In order to investigate the mechanisms of acute cerebral ischemia,and to look for effective drugs on cerebral resuscitation,we made a model of acute complete global brain ischemia,reperfusion and resuscita-tion on rats according to Garavilla's method.Our results showed that the event of cerebral ischemia and reperfusion injury could result in the in-crease of total brain calcium content,and anisodamine has the same reducing brain calcium contents as dil-tiazem's,while improving neurological outcome and alleviating injury to neurons.

  6. Normal cerebral FDG uptake during childhood

    Energy Technology Data Exchange (ETDEWEB)

    London, Kevin [The Children' s Hospital at Westmead, Department of Nuclear Medicine, Sydney, NSW (Australia); University of Sydney, Discipline of Paediatrics and Child Health, Sydney Medical School, Sydney, NSW (Australia); Howman-Giles, Robert [The Children' s Hospital at Westmead, Department of Nuclear Medicine, Sydney, NSW (Australia); University of Sydney, Disciplines of Imaging and Paediatrics and Child Health, Sydney Medical School, Sydney, NSW (Australia)

    2014-04-15

    Current understanding of cerebral FDG uptake during childhood originates from a small number of studies in patients with neurological abnormalities. Our aim was to describe cerebral FDG uptake in a dataset of FDG PET scans in children more likely to represent a normal population. We reviewed cerebral FDG PET scans in children up to 16 years of age with suspected/proven extracranial malignancies and the following exclusions: central nervous system metastases, previous malignancies, previous chemotherapy or radiotherapy, development of cerebral metastases during therapy, neurological conditions, taking antiepileptic medication or medications likely to interfere with cerebral metabolism, and general anaesthesia within 24 h. White matter, basal ganglia, thalamus and the cerebellar cortex were analysed using regional SUV{sub max}, and the cerebral cortex, basal ganglia, thalamus and cerebellum were analysed using a regional relative uptake analysis in comparison to maximal cortical uptake. Scans from 30 patients (age range 11 months to 16 years, mean age 10 years 5 months) were included. All regions showed increasing SUV{sub max} with age. The parietal, occipital, lateral temporal and medial temporal lobes showed lower rates of increasing FDG uptake causing changing patterns of regional FDG uptake during childhood. The cortical regions showing the most intense uptake in early childhood were the parietal and occipital lobes. At approximately 7 years of age these regions had relatively less uptake than the frontal lobes and at approximately 10 years of age these regions had relatively less uptake than the thalamus. Relative FDG uptake in the brain has not reached an adult pattern by 1 year of age, but continues to change up to 16 years of age. The changing pattern is due to different regional rates of increasing cortical FDG uptake, which is less rapid in the parietal, occipital and temporal lobes than in the frontal lobes. (orig.)

  7. Normal cerebral FDG uptake during childhood

    International Nuclear Information System (INIS)

    Current understanding of cerebral FDG uptake during childhood originates from a small number of studies in patients with neurological abnormalities. Our aim was to describe cerebral FDG uptake in a dataset of FDG PET scans in children more likely to represent a normal population. We reviewed cerebral FDG PET scans in children up to 16 years of age with suspected/proven extracranial malignancies and the following exclusions: central nervous system metastases, previous malignancies, previous chemotherapy or radiotherapy, development of cerebral metastases during therapy, neurological conditions, taking antiepileptic medication or medications likely to interfere with cerebral metabolism, and general anaesthesia within 24 h. White matter, basal ganglia, thalamus and the cerebellar cortex were analysed using regional SUVmax, and the cerebral cortex, basal ganglia, thalamus and cerebellum were analysed using a regional relative uptake analysis in comparison to maximal cortical uptake. Scans from 30 patients (age range 11 months to 16 years, mean age 10 years 5 months) were included. All regions showed increasing SUVmax with age. The parietal, occipital, lateral temporal and medial temporal lobes showed lower rates of increasing FDG uptake causing changing patterns of regional FDG uptake during childhood. The cortical regions showing the most intense uptake in early childhood were the parietal and occipital lobes. At approximately 7 years of age these regions had relatively less uptake than the frontal lobes and at approximately 10 years of age these regions had relatively less uptake than the thalamus. Relative FDG uptake in the brain has not reached an adult pattern by 1 year of age, but continues to change up to 16 years of age. The changing pattern is due to different regional rates of increasing cortical FDG uptake, which is less rapid in the parietal, occipital and temporal lobes than in the frontal lobes. (orig.)

  8. Miotoxicidade por organofosforados Organophosphate myotoxicity

    Directory of Open Access Journals (Sweden)

    Maria J. Cavaliere

    1996-06-01

    Full Text Available Os organofosforados são um grupo de compostos químicos amplamente utilizados em agropecuária como inseticidas, ocasionando intoxicações acidentais em animais e humanos, e mesmo sendo utilizados em tentativas de suicídio. A toxicidade desses produtos decorre sobretudo de insuficiência cárdio-respiratória por compromentimento do sistema nervoso autônomo. Sabe-se que alguns destes compostos induzem em animais de experimentação e em humanos, uma miopatia caracterizada por degeneração de células musculares, comprometendo sobretudo a musculatura respiratória. Baseado no fato de que este comprometimento contribui para a piora da função respiratória, propõe-se um protocolo de avaliação rotineira de miotoxicidade por compostos organofosforados, através de uma bateria mínima e suficiente de colorações e reações histoquímicas para quantificação da necrose muscular. Utilizaram-se como modelo experimental, grupos de ratos albinos (Wistar intoxicados com o organofosforado paraoxon, com e sem antídotos (atropina ou pralidoxima. Verificou-se nos grupos tratados com paraoxon e paraoxon mais atropina, necrose de fibras musculares no diafragma, que atingia em determinadas áreas até 15% das fibras. No grupo tratado com paraoxon mais pralidoxima, a necrose foi mínima, evidenciando o papel mioprotetor deste último antídoto.Organophosphates comprise a group of chemical compounds extensively used in farming as insecticides, which cause accidental poisoning in animals and men and are also used in suicide attempts. The toxicity of these compounds is due especially to the cardiac and respiratory impairment in consequence of autonomic nervous system disorders. However, it is known that some of these products induce a myopathy in experimental animals and humans. This myopathy is characterized by muscle cell degeneration, involving above all the respiratory muscles. Based on the fact that this involvement certainly enhances the

  9. Reprogramación celular de embriones de Anthurium andraeanum por fitohormonas para micropropagación masiva

    Directory of Open Access Journals (Sweden)

    Julieta Mireles-Ordaz

    2015-01-01

    Full Text Available El género Anthurium incluye alrededor de 800 especies, las cuales son originarias de diversos países tropicales y subtropicales de América. Numerosos cultivos de estas especies de Anthurium son crecidos y comercializados debido a su gran popularidad como plantas ornamentales alrededor de todo el mundo, de las cuales la más popular es Anthurium andreanum. La reproducción sexual de estas plantas en invernaderos es difícil y toma mucho tiempo, lo cual representa una desventaja para su producción masiva y comercialización. La micropropagación in vitro ha emergido como una opción para sobrellevar dicha desventaja, hasta la fecha se han logrado avances parcialmente exitosos en la micropropagación en especies de Anthurium usando varios tejidos como explantes iniciales, incluyendo hojas, pecíolo, espádice, espata, brote lateral, meristemo apical y embriones somáticos, estos últimos previamente inducidos a partir de tejido diferenciado. Sin embargo, hasta ahora no hay reportes del uso de embriones cigóticos como tejido madre para la propagación masiva de estas plantas. En el presente estudio reportamos la formación de callos organogénicos a partir de embriones cigóticos inmaduros crecidos en medio MS suplementado con la combinación de 2 mg/l de ácido 2,4-diclorofenoxiacético (2,4-D y 0.5 mg/l de 6-benzilamino-purina (BAP. Los resultados obtenidos demuestran que los embriones en proceso de desarrollo son altamente eficientes como explantes de origen para inducir la formación de tejido calloso de una manera rápida y fácil, dando en promedio 9 brotes por callo y logrando una taza de sobrevivencia de las plantas del 90% en la fase de aclimatación.

  10. Radiotherapy for Small Cerebral Arteriovenous Malformation

    OpenAIRE

    Yamashita, Tetsuo; Kurokawa, Yasushi; Kashiwagi, Shiro; Abiko, Seisho; Shiroyama, Yujiro; Kamiryo, Toshifumi; Nakano, Shigeki; Eguchi, Yuuki; Tsurutani, Toru; Ito, Haruhide

    1991-01-01

    The result of two types of radiation therapy for small cerebral arteriovenous malformations (AVM) were analyzed, and the indications and limitations of radiation therapy for small AVMs discussed. Four patients with small AVMs received radiation therapy. There were three males and one female, ranging in age from 7 to 44 years with an average of 29 years. One cerebral AVM was located in the right thalamus, two were in the left central sulcus and one was in the left parietal lobe. Three AVMs wer...

  11. Electrical Cerebral Stimulation Modifies Inhibitory Systems

    Science.gov (United States)

    Cuéllar-Herrera, M.; Rocha, L.

    2003-09-01

    Electrical stimulation of the nervous tissue has been proposed as a method to treat some neurological disorders, such as epilepsy. Epileptic seizures result from excessive, synchronous, abnormal firing patterns of neurons that are located predominantly in the cerebral cortex. Many people with epilepsy continue presenting seizures even though they are under regimens of antiepileptic medications. An alternative therapy for treatment resistant epilepsy is cerebral electrical stimulation. The present study is focused to review the effects of different types of electrical stimulation and specifically changes in amino acids.

  12. Reversible cerebral vasconstriction syndrome: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Sub; Park, Ji Kang; Kim, Seung Hyoung; Jeong, Sun Young [Jeju National University Hospital, Jeju National University School of Medicine, Jeju (Korea, Republic of)

    2013-11-15

    We report a 46-year-old woman patient with reversible cerebral vasoconstriction syndrome (RCVS). She presented with severe headache, multiple cerebral infarction, and multifocal severe stenosis in the intracranial arteries on magnetic resonance angiography (MRA). One month after the episode, a small bowel gastrointestinal stromal tumor (GIST) was incidentally detected during the evaluation of severe anemia and GIST was removed. Follow-up MRA was performed 3 months and 1 year after an initial attack of headache, and multifocal severe intracranial arterial stenotic lesions were completely resolved, she did not experience any episode of RCVS during the 2 years.

  13. Maternal Infections during Pregnancy and Cerebral Palsy

    DEFF Research Database (Denmark)

    Miller, Jessica; Pedersen, Lars Henning; Streja, Elani;

    2013-01-01

    BACKGROUND: Cerebral palsy (CP) is a common motor disability in childhood. We examined the association between maternal infections during pregnancy and the risk of congenital CP in the child. METHODS: Liveborn singletons in Denmark between 1997 and 2003 were identified from the Danish National...... the Danish Cerebral Palsy Registry. Adjusted hazard ratio (HR) and 95% confidence interval (CI) were estimated by Cox proportional hazard models. RESULTS: Of the 440 564 singletons with follow-up data, 840 were diagnosed with congenital CP. Maternal genito-urinary tract infections (HR 2.1, 95% CI 1.4, 3...

  14. Education and employment prospects in cerebral palsy

    DEFF Research Database (Denmark)

    Michelsen, Susan Ishøy; Uldall, Peter; Kejs, Anne Mette T;

    2005-01-01

    Parents and paediatric neurologists need information on the long-term social prognosis of children with cerebral palsy (CP). No large population-based study has been performed on this topic. On 31 December 1999, to find predictors in childhood of subsequent education and employment, 819...... participants with CP born between 1965 and 1978 (471 males; mean age 28y 10 mo, SD 4y, range 21 to 35y) in the Danish Cerebral Palsy Registry were compared with 4406 controls without CP born between 1965 and 1978 (2546 males; mean age 28y 10 mo, SD 4y, range 21 to 35y). Diagnostic subtypes of the 819...

  15. Epidemiology of cerebral palsy in Southern Denmark

    DEFF Research Database (Denmark)

    Frøslev-Friis, Christina; Dunkhase-Heinl, Ulrike; Andersen, Johnny Dohn Holmgren;

    2015-01-01

    INTRODUCTION: The aim of this study was to describe the prevalence, subtypes, severity and neuroimaging findings of cerebral palsy (CP) in a cohort of children born in Southern Denmark. Risk factors were analysed and aetiology considered. METHODS: A population-based cohort study covering 17...... prevention of CP is possible if the numbers of preterm births and multiple pregnancies can be reduced. FUNDING: The Danish Cerebral Palsy Follow-up Programme is supported by the foundation "Ludvig og Sara Elsass Fond". TRIAL REGISTRATION: 2008-58-0034....

  16. Experimental thrombolysis of middle cerebral artery thromboemboli

    International Nuclear Information System (INIS)

    Since the majority of ischaemic cerebral infarcts is caused by thromboemboli, we determined the benefit of firbrinolytic therapy in acute stroke. Thromboemboli were induced in the middle cerebral artery of 21 dogs. Urokinase was started at different time intervals after infarction (1, 3 and 5 hours) at a rate of 1000 IU/kg/min. Angiographically controlled thrombolysis was achieved in all 15 treated cases, whereas in the control group (n=6) no case of recanalisation was observed. Systemic fibrinolysis occurred in all cases. Postmortem examinations of the brains showed no intracerebral haemorrhages. Our findings indicate the urokinase treatment may be of value in acute ischaemic stroke. (orig.)

  17. Progressive cerebral atrophy in neuromyelitis optica.

    Science.gov (United States)

    Warabi, Yoko; Takahashi, Toshiyuki; Isozaki, Eiji

    2015-12-01

    We report two cases of neuromyelitis optica patients with progressive cerebral atrophy. The patients exhibited characteristic clinical features, including elderly onset, secondary progressive tetraparesis and cognitive impairment, abnormally elevated CSF protein and myelin basic protein levels, and extremely highly elevated serum anti-AQP-4 antibody titer. Because neuromyelitis optica pathology cannot switch from an inflammatory phase to the degenerative phase until the terminal phase, neuromyelitis optica rarely appears as a secondary progressive clinical course caused by axonal degeneration. However, severe intrathecal inflammation and massive destruction of neuroglia could cause a secondary progressive clinical course associated with cerebral atrophy in neuromyelitis optica patients.

  18. CEREBRAL ARTERIOVENOUS MALFORMATIONS IN CHILDREN. ENDOVASCULAR TREATMENT

    OpenAIRE

    Scheglov, D.; Zagorodniy, V.

    2013-01-01

    The objective — to learn the features of the cerebral arteriovenous malformations (АVМ) endovascular treatment in children. Materials and methods. Totally 39 children with cerebral AVMs were treated at the center from 2005 to 2012. The average age of the patients (12.6 ± 1.2) years. It was found that the most of AVMs were occurred in temporoparietal subcortical area — 46.2 % cases. Results. Small size of AVMs were detected in 15.4 % of patients, the middle — in 33.3 %, the large — in 38.5 %, ...

  19. Neurociências, neurocultura e autoajuda cerebral

    OpenAIRE

    Francisco Ortega

    2009-01-01

    Este artigo pretende analisar o fenômeno denominado de neuroascese, ou autoajuda cerebral no contexto do crescente impacto das neurociências e do surgimento da neurocultura e do sujeito cerebral. Para tanto, é importante compreender o âmbito sóciocultural mais amplo no qual a neuroascese se insere e que corresponde ao que vem se chamando de 'cultura somática' ou, mais especificamente, de biossociabilidade. O objetivo do artigo é explorar como uma forma de subjetividade reducionista, o sujeito...

  20. [Cerebral salt wasting syndrome in bacterial meningitis].

    Science.gov (United States)

    Attout, H; Guez, S; Seriès, C

    2007-10-01

    Subarachnoid hemorrhage is the most common cause of cerebral salt wasting syndrome. There are few reports of this condition in infectious meningitis. We describe a patient with hyponatremia and bacterial meningitis. Hyponatremia rapidly improved after administration of sodium chloride. The purpose of this report is to alert clinicians to the fact that hyponatremic patients with central nervous system disease do not necessarily have a syndrome of inappropriate secretion of antidiuretic hormone (SIADH), but may have cerebral salt wasting syndrome. By contrast with SIADH, the treatment requires saline administration.