Shear Evaluation by Quantitative Flow Visualization Near the Casing Surface of a Centrifugal Blood Pump

Science.gov (United States)

Nishida, Masahiro; Yamane, Takashi; Tsukamoto, Yuki; Ito, Kazuyuki; Konishi, Yoshiaki; Masuzawa, Toru; Tsukiya, Tomonori; Endo, Seiko; Taenaka, Yoshiyuki

To clarify the correlation between high-shear flow and hemolysis in blood pumps, detail shear velocity distribution was quantified by an experimental method with a model centrifugal blood pump that has a series data of hemolysis tests and computational fluid dynamic analyses. Particular attention was paid to the shear velocity near the casing surface in the volute where the high shear causes in circumferentially wide region that is considerable to cause high hemolysis. Three pump models were compared concern with the radial gap width between the impeller and casing (the radial volute width) also with the outlet position whereas the impeller geometry was identical. These casing geometries were as follows: model 1-the gap width is standard 3mm and the outlet locates to make a smooth geometrical connection with the volute, model 2-the gap width is small 0.5mm and the outlet locates to make the smooth geometrical connection with the volute, and model 3-the gap width is small 0.5mm and the outlet locates to hardly make the smooth geometrical connection with the volute but be similar radial position with that of model 1. Velocity was quantified with a particle tracking velocimetry that is one of the quantitative flow visualization techniques, and the shear velocity was calculated. Results showed that all large shear velocity existed within the layers of about 0.1mm from the casing surface and that those layers were hardly affected by a vane passage even if the gap width is 0.5mm. They also showed that the maximum shear velocity appeared on the casing surface, and the shear velocities of models 2 and 3 were almost twice as large as that of model 1. This finding is in full corresponding with the results of hemolysis tests which showed that the hemolysis levels of both models 2 and 3 were 1.5 times higher than that of model 1. These results suggest that detailed high-shear evaluation near the casing surface in the volute is one of the most important keys in estimating the

Estimation of the radial force using a disturbance force observer for a magnetically levitated centrifugal blood pump.

Science.gov (United States)

Pai, C N; Shinshi, T; Shimokohbe, A

2010-01-01

Evaluation of the hydraulic forces in a magnetically levitated (maglev) centrifugal blood pump is important from the point of view of the magnetic bearing design. Direct measurement is difficult due to the absence of a rotor shaft, and computational fluid dynamic analysis demands considerable computational resource and time. To solve this problem, disturbance force observers were developed, using the radial controlled magnetic bearing of a centrifugal blood pump, to estimate the radial forces on the maglev impeller. In order to design the disturbance observer, the radial dynamic characteristics of a maglev impeller were evaluated under different working conditions. It was observed that the working fluid affects the additional mass and damping, while the rotational speed affects the damping and stiffness of the maglev system. Based on these results, disturbance force observers were designed and implemented. The designed disturbance force observers present a bandwidth of 45 Hz. In non-pulsatile conditions, the magnitude of the estimated radial thrust increases in proportion to the flowrate, and the rotational speed has little effect on the force direction. At 5 l/min against 100 mmHg, the estimated radial thrust is 0.95 N. In pulsatile conditions, this method was capable of estimating the pulsatile radial thrust with good response.

Design and construction of a two-stage centrifugal pump | Nordiana ...

African Journals Online (AJOL)

Centrifugal pumps are widely used in moving liquids from one location to another in homes, offices and industries. Due to the ever increasing demand for centrifugal pumps it became necessary to design and construction of a two-stage centrifugal pump. The pump consisted of an electric motor, a shaft, two rotating impellers ...

LMR [liquid metal reactor] centrifugal pump coastdowns

International Nuclear Information System (INIS)

Dunn, F.E.; Malloy, D.J.

1987-01-01

A centrifugal pump model which describes the interrelationships of the pump discharge flowrate, pump speed, shaft torque and dynamic head has been implemented based upon existing models. Specifically, the pump model is based upon the dimensionless-homologous pump theory of Wylie and Streeter. Given data from a representative pump, homologous theory allows one to predict the transient characteristics of similarly sized pumps. This homologous pump model has been implemented into both the one-dimensional SASSYS-1 systems analysis code and the three-dimensional COMMIX-1A code. Comparisons have been made both against other pump models (CRBR) and actual pump coastdown data (EBR-II and FFTF). Agreement with this homologous pump model has been excellent. Additionally, these comparisons indicate the validity of applying the medium size pump data of Wylie and Streeter to a range of typical LMR centrifugal pumps

Damages on pumps and systems the handbook for the operation of centrifugal pumps

CERN Document Server

Merkle, Thomas

2014-01-01

Damage on Pumps and Systems. The Handbook for the Operation of Centrifugal Pumps offers a combination of the theoretical basics and practical experience for the operation of circulation pumps in the engineering industry. Centrifugal pumps and systems are extremely vulnerable to damage from a variety of causes, but the resulting breakdown can be prevented by ensuring that these pumps and systems are operated properly. This book provides a total overview of operating centrifugal pumps, including condition monitoring, preventive maintenance, life cycle costs, energy savings and economic aspects. Extra emphasis is given to the potential damage to these pumps and systems, and what can be done to prevent breakdown. Addresses specific issues about pumping of metal chips, sand, abrasive dust and other solids in fluidsEmphasis on economic and efficiency aspects of predictive maintenance and condition monitoring Uses life cycle costs (LCC) to evaluate and calculate the costs of pumping systems

The effect of balance holes to centrifugal pump performance

Science.gov (United States)

Babayigit, O.; Ozgoren, M.; Aksoy, M. H.; Kocaaslan, O.

2017-07-01

The aim of this study is to analyze of a centrifugal pump with and without balance holes by using ANSYS-Fluent software. The pump used in the study is a commercial centrifugal pump consisting of two stages that is a model of Sempa Pump Company. Firstly, models of impeller, diffuser, suction and discharge sections of the centrifugal pump were separately drawn using Ansys and Solidworks software. Later, grid structures were generated on the flow volume of the pump. Turbulent flow volume was numerically solved by realizable k-є turbulence model. The flow analyses were focused on the centrifugal pump performance and the flow characteristics under different operational conditions with/without balance holes. Distributions of flow characteristics such as velocity and pressure distributions in the flow volume were also determined, numerically. The results of Computational Fluid Dynamics (CFD) with/without balance holes for the pump head and hydraulic efficiency on the design flow rate of 80 m3/h were found to be 81.5/91.3 m and 51.9/65.3%, respectively.

Tolerance of centrifuge-simulated suborbital spaceflight in subjects with implanted insulin pumps.

Science.gov (United States)

Levin, Dana R; Blue, Rebecca S; Castleberry, Tarah L; Vanderploeg, James M

2015-04-01

With commercial spaceflight comes the possibility of spaceflight participants (SFPs) with significant medical conditions. Those with previously untested medical conditions, such as diabetes mellitus (DM) and the use of indwelling medical devices, represent a unique challenge. It is unclear how SFPs with such devices will react to the stresses of spaceflight. This case report describes two subjects with Type I DM using insulin pumps who underwent simulated dynamic phases of spaceflight via centrifuge G force exposure. Two Type I diabetic subjects with indwelling Humalog insulin pumps, a 23-yr-old man averaging 50 u of Humalog daily and a 27-yr-old man averaging 60 u of Humalog daily, underwent seven centrifuge runs over 48 h. Day 1 consisted of two +Gz runs (peak = +3.5 Gz, run 2) and two +Gx runs (peak = +6.0 Gx, run 4). Day 2 consisted of three runs approximating suborbital spaceflight profiles (combined +Gx and +Gz). Data collected included blood pressure, electrocardiogram, pulse oximetry, neurovestibular evaluation, and questionnaires regarding motion sickness, disorientation, greyout, and other symptoms. Neither subject experienced adverse clinical responses to the centrifuge exposure. Both maintained blood glucose levels between 110-206 mg · dl(-1). Potential risks to SFPs with insulin pump dependent DM include hypo/hyperglycemia, pump damage, neurovestibular dysfunction, skin breakdown, and abnormal stress responses. A search of prior literature did not reveal any previous studies of individuals with DM on insulin pumps exposed to prolonged accelerations. These cases suggest that individuals with conditions dependent on continuous medication delivery might tolerate the accelerations anticipated for commercial spaceflight.

Centrifugal pumps and allied machinery

CERN Document Server

Anderson, HH

1994-01-01

This book will be of vital interest to all engineers and designers concerned with centrifugal pumps and turbines. Including statistical information derived from 20000 pumps and 700 turbines with capacities of 5gpm to 5000000gpm, this book offers the widest range and scope of information currently available. Statistical analyses suggest practical methods of increasing pump performance and provide valuable data for new design aspects.

Reflection of centrifugal pumps maintenance

International Nuclear Information System (INIS)

Mozos Fernandez, V.

2010-01-01

The aim of this work is to prove that is not necessary a deep and complex knowledge to manage the centrifugal pumps maintenance. According to the author, only deep but single technical knowledge about causes of breakdowns in the different and simple component parts of the pumps, are required. (Author)

Cavitation simulation and NPSH prediction of a double suction centrifugal pump

International Nuclear Information System (INIS)

Li, P; Huang, Y F; Li, J

2012-01-01

This paper illustrates the flow field numerical analysis of the double-suction centrifugal pump. For the study of the cavitation flow inside the double-suction centrifugal pump, the professional pump/motor simulation software PumpLinx and its Full Cavitation Model has been employed. According to the PumpLinx calculation result and the Cavitation damage index, the cavitation position, level and the cavitation characteristics of the double-suction centrifugal pump has been predicted. For the further objective, the simulation of the flow field in the double-suction centrifugal pump under different inlet conditions has been carried out. By the result analysis, NPSHr has been predicted; the reliability of the results has been verified by comparing with the experimental data. At the same time, this practice can provide guidance for the optimal design of double-suction pump.

Shaft/shaft-seal interface characteristics of a multiple disk centrifugal blood pump.

Science.gov (United States)

Manning, K B; Miller, G E

1999-06-01

A multiple disk centrifugal pump (MDCP) is under investigation as a potential left ventricular assist device. As is the case with most shaft driven pumps, leakage problems around the shaft/shaft seal interface are of major interest. If leakage were to occur during or after implantation, potential events such as blood loss, clotting, blood damage, and/or infections might result in adverse effects for the patient. Because these effects could be quite disastrous, potential shaft and shaft seal materials have been investigated to determine the most appropriate course to limit these effects. Teflon and nylon shaft seals were analyzed as potential candidates along with a stainless steel shaft and a Melonite coated shaft. The materials and shafts were evaluated under various time durations (15, 30, 45, and 60 min), motor speeds (800, 1,000, 1,200, and 1,400 rpm), and outer diameters (1/2 and 3/4 inches). The motor speed and geometrical configurations were typical for the MDCP under normal physiologic conditions. An air and water study was conducted to analyze the inner diameter wear, the inner temperature values, and the outer temperature values. Statistical comparisons were computed for the shaft seal materials, the shafts, and the outer diameters along with the inner and outer temperatures. The conclusions made from the results indicate that both the tested shaft seal materials and shaft materials are not ideal candidates to be used for the MDCP. Teflon experienced a significant amount of wear in air and water studies. Nylon did experience little wear, but heat generation was an evident problem. A water study on nylon was not conducted because of its molecular structure.

Fluid dynamic interaction between water hammer and centrifugal pumps

International Nuclear Information System (INIS)

Ismaier, A.; Schluecker, E.

2009-01-01

Centrifugal pumps generate in piping systems noticeable pressure pulsations. In this paper the dynamic interaction between water hammer and pressure pulsations is presented. The experimental investigations were performed at a piping system with nominal diameter DN 100 (respectively NPS 4) and 75 m total length, built at the Institute for Process Technology and Machinery. Different measurements at this testing facility show that pulsating centrifugal pumps can damp pressure surges generated by fast valve closing. It is also shown that 1-dimensional fluid codes can be used to calculate this phenomenon. Furthermore it is presented that pressure surges pass centrifugal pumps almost unhindered, because they are hydraulic open.

Open-heart surgery using a centrifugal pump: a case of hereditary spherocytosis.

Science.gov (United States)

Matsuzaki, Yuichi; Tomioka, Hideyuki; Saso, Masaki; Azuma, Takashi; Saito, Satoshi; Aomi, Shigeyuki; Yamazaki, Kenji

2016-08-26

Hereditary spherocytosis is a genetic, frequently familial hemolytic blood disease characterized by varying degrees of hemolytic anemia, splenomegaly, and jaundice. There are few reports on adult open-heart surgery for patients with hereditary spherocytosis. We report a rare case of an adult open-heart surgery associated with hereditary spherocytosis. A 63-year-old man was admitted for congestive heart failure due to bicuspid aortic valve, aortic valve regurgitation, and sinus of subaortic aneurysm. The family history, the microscopic findings of the blood smear, and the characteristic osmotic fragility confirmed the diagnosis of hereditary spherocytosis. Furthermore, splenectomy had not been undertaken preoperatively. The patient underwent a successful operation by means of a centrifugal pump. Haptoglobin was used during the cardiopulmonary bypass, and a biological valve was selected to prevent hemolysis. No significant hemolysis occurred intraoperatively or postoperatively. There are no previous reports of patients with hereditary spherocytosis, and bicuspid aortic valve. We have successfully performed an adult open-heart surgery using a centrifugal pump in an adult patient suffering from hereditary spherocytosis and bicuspid aortic valve.

Evaluation of a Spiral Groove Geometry for Improvement of Hemolysis Level in a Hydrodynamically Levitated Centrifugal Blood Pump.

Science.gov (United States)

Murashige, Tomotaka; Kosaka, Ryo; Sakota, Daisuke; Nishida, Masahiro; Kawaguchi, Yasuo; Yamane, Takashi; Maruyama, Osamu

2015-08-01

The purpose of this study is to evaluate a spiral groove geometry for a thrust bearing to improve the hemolysis level in a hydrodynamically levitated centrifugal blood pump. We compared three geometric models: (i) the groove width is the same as the ridge width at any given polar coordinate (conventional model); (ii) the groove width contracts inward from 9.7 to 0.5 mm (contraction model); and (iii) the groove width expands inward from 0.5 to 4.2 mm (expansion model). To evaluate the hemolysis level, an impeller levitation performance test and in vitro hemolysis test were conducted using a mock circulation loop. In these tests, the driving conditions were set at a pressure head of 200 mm Hg and a flow rate of 4.0 L/min. As a result of the impeller levitation performance test, the bottom bearing gaps of the contraction and conventional models were 88 and 25 μm, respectively. The impeller of the expansion model touched the bottom housing. In the hemolysis test, the relative normalized index of hemolysis (NIH) ratios of the contraction model in comparison with BPX-80 and HPM-15 were 0.6 and 0.9, respectively. In contrast, the relative NIH ratios of the conventional model in comparison with BPX-80 and HPM-15 were 9.6 and 13.7, respectively. We confirmed that the contraction model achieved a large bearing gap and improved the hemolysis level in a hydrodynamically levitated centrifugal blood pump. Copyright © 2015 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

Forces on Centrifugal Pump Impellers

OpenAIRE

Jery, Belgacem; Brennen, Christopher E.; Caughey, Thomas K.; Acosta, Allan

1985-01-01

Forces are exerted on a centrifugal pump impeller, due to the asymmetry of the flow caused by the volute of diffuser, and to the motion of the center of the impeller whenever the shaft whirls. Recent work in the measurement of these forces as a function of the whirl speed to shaft speed ratio, and the influence of the volute, is reviewed. These forces may be decomposed into a steady force, a static stiffness matrix, a damping matrix and an inertia matrix. It is shown that for centrifugal p...

New centrifugation blood culture device.

Science.gov (United States)

Dorn, G L; Smith, K

1978-01-01

A single-tube blood culture device designed for centrifugation in a tabletop centrifuge is described. Reconstruction experiments using 21 different organisms and human donor blood indicate that excellent recovery can be obtained by centrifugation for 30 min at 3,000 X g. PMID:342539

Fault Detection and Isolation in Centrifugal Pumps

DEFF Research Database (Denmark)

Kallesøe, Carsten

Centrifugal pumps are used in a variety of different applications, such as water supply, wastewater, and different industrial applications. Some pump installations are crucial for the applications to work. Failures can lead to substantial economic losses and can influence the life of many people...

Development of real-time and quantitative monitoring of thrombus formation in an extracorporeal centrifugal blood pump

Science.gov (United States)

Sakota, Daisuke; Fujiwara, Tatsuki; Ohuchi, Katsuhiro; Kuwana, Katsuyuki; Yamazaki, Hiroyuki; Kosaka, Ryo; Maruyama, Osamu

2018-02-01

We developed an optical detector of thrombus formed on the pivot bearing of an extracorporeal centrifugal blood pump (MERA HCF-MP23; Senko Medical Instrument Mfg. Co., Ltd., Tokyo, Japan) which is frequently used for long-term extracorporeal circulation support to bridge to an implantable artificial heart, which in turn is used for bridge to heart transplantation in Japan. In this study, we investigated the quantitative performance of the thrombus formation in acute animal experiments. A total of three experiments of extracorporeal left ventricular assist using Japanese specific pathogen-free pigs were conducted. The optical fibers were set in the pump driver unit. The incident light at nearinfrared wavelength aiming at the pivot bearing and the resulting scattered light were guided to respective fibers. The detected signal was analyzed to obtain thrombus formation level (TFL) calculated by a specially developed software. When the increase in TFL was confirmed, the pump was exchanged and the extracorporeal circulation was restarted. The number of pump exchanges were four times at each experiment so a total of twelve pumps were evaluated. 3-dimentional data surrounding the pivot bearing and the adhered thrombus was captured by a 3-dimantional surface measurement system to calculate the thrombus surface area (TSA) formed on the pivot bearing. As a result, the correlation coefficient between TFL and TSA was 0.878. The accuracy of TSA estimated by the optical detector was 3.6+/-2.3 mm2. This was small enough to not have the pump exchanged in clinical judgement. The developed detector would be useful for optimal anti-coagulation management.

Development of a real-time and quantitative thrombus sensor for an extracorporeal centrifugal blood pump by near-infrared light.

Science.gov (United States)

Sakota, Daisuke; Fujiwara, Tatsuki; Ohuchi, Katsuhiro; Kuwana, Katsuyuki; Yamazaki, Hiroyuki; Kosaka, Ryo; Nishida, Masahiro; Mizuno, Tomohiro; Arai, Hirokuni; Maruyama, Osamu

2018-01-01

We developed an optical thrombus sensor for a monopivot extracorporeal centrifugal blood pump. In this study, we investigated its quantitative performance for thrombus detection in acute animal experiments of left ventricular assist using the pump on pathogen-free pigs. Optical fibers were set in the driver unit of the pump. The incident light at the near-infrared wavelength of 810 nm was aimed at the pivot bearing, and the resulting scattered light was guided to the optical fibers. The detected signal was analyzed to obtain the thrombus formation level. As a result, real-time and quantitative monitoring of the thrombus surface area on the pivot bearing was achieved with an accuracy of 3.6 ± 2.3 mm 2 . In addition, the sensing method using the near-infrared light was not influenced by changes in the oxygen saturation and the hematocrit. It is expected that the developed sensor will be useful for optimal anticoagulation management for long-term extracorporeal circulation therapies.

Performance and internal flow condition of mini centrifugal pump with splitter blades

International Nuclear Information System (INIS)

Shigemitsu, T; Fukutomi, J; Kaji, K; Wada, T

2012-01-01

Mini centrifugal pumps having a diameter smaller than 100mm are employed in many fields. But the design method for the mini centrifugal pump is not established because the internal flow condition for these small-sized fluid machines is not clarified and conventional theory is not suitable for small-sized pumps. Therefore, mini centrifugal pumps with simple structure were investigated by this research. Splitter blades were adopted in this research to improve the performance and the internal flow condition of mini centrifugal pump which had large blade outlet angle. The original impeller without the splitter blades and the impeller with the splitter blades were prepared for an experiment. The performance tests are conducted with these rotors in order to investigate the effect of the splitter blades on performance and internal flow condition of mini centrifugal pump. On the other hand, a three dimensional steady numerical flow analysis is conducted with the commercial code (ANSYS-CFX) to investigate the internal flow condition in detail. It is clarified from the experimental results that the performance of the mini centrifugal pump is improved by the effect of the splitter blades. The blade-to-blade low velocity regions are suppressed in the case with the splitter blades and the total pressure loss regions are decreased. The effects of the splitter blades on the performance and the internal flow condition are discussed in this paper.

Research on energy conversion mechanism of a screw centrifugal pump under the water

International Nuclear Information System (INIS)

Quan, H; Li, R N; Han, W; Cheng, X R; Shen, Z J; Su, Q M

2013-01-01

In order to research screw centrifugal pump impeller power capability and energy conversion mechanism, we used Navier-Stokes equation and standard k-ε equation turbulence model on the basis of the Euler equations to carry out screw centrifugal pump internal flow numerical simulation. This was explored by simulating specific design conditions; the medium is water, variation of speed and pressure of flow filed under the action of the impeller, and the screw centrifugal impeller shroud line and wheel line segment take monitoring sites. The monitoring points are between dynamic head and static head change to analyze the energy conversion capability along the impeller corners of screw centrifugal pump. The results show that the energy of fluid of the screw centrifugal pump is provided by spiral segment, the spiral segment in front of the impeller has played a multi-level role, it has significant reference value to research the energy conversion mechanism of screw centrifugal pump under solid-liquid two phase

Centrifugal Pump Effect on Average Particle Diameter of Oil-Water Emulsion

Science.gov (United States)

Morozova, A.; Eskin, A.

2017-11-01

In this paper we review the process of oil-water emulsion particles fragmentation in a turbulent flow created by a centrifugal pump. We examined the influence of time necessary for oil-water emulsion preparation on the particle size of oil products and the dependence of a centrifugal pump emulsifying capacity on the initial emulsion dispersion. The investigated emulsion contained the brand fuel oil M-100 and tap water; it was sprayed with a nozzle in a gas-water flare. After preparation of the emulsion, the centrifugal pump was turned on and the emulsion samples were taken before and after the pump passing in 15, 30 and 45 minutes of spraying. To determine the effect the centrifugal pump has on the dispersion of the oil-water emulsion, the mean particle diameter of the emulsion particles was determined by the optical and microscopic method before and after the pump passing. A dispersion analysis of the particles contained in the emulsion was carried out by a laser diffraction analyzer. By analyzing the pictures of the emulsion samples, it was determined that after the centrifugal pump operation a particle size of oil products decreases. This result is also confirmed by the distribution of the obtained analyzer where the content of fine particles with a diameter less than 10 μm increased from 12% to 23%. In case of increasing emulsion preparation time, a particle size of petroleum products also decreases.

Applicability of eddy viscosity turbulence models in low specific speed centrifugal pump

International Nuclear Information System (INIS)

Wang, Y; Wang, W J

2012-01-01

The accuracy of numerical simulation determines the performance prediction whether to be successful or not in the research of centrifugal pump. In order to study the applicability of different turbulence models in the low specific speed centrifugal pump, the object was based on XST45-200 stamping and welding centrifugal pump. Five different kinds of standards which are k-ε model, RNG k-ε model, Realizable k-ε model, Standard k-ω model and SST k-ω model are adopted in steady numerical simulations of the centrifugal pump flow fields. Then, inner and outside characteristics of the centrifugal pump were gotten .And it also provides the calculation of pressure distribution using different turbulence models in the five conditions. Lastly, the performance curves of head, power and efficiency are compared with the test. The results show a good agreement between five kinds of turbulence models and tests obtained in small flow and design condition. In large flow, the standard k-ε model is worse than the other four, which is larger than the tested head with a relative deviation of 47.9% and efficiency with 50%.The calculation accuracy which used RNG k-ε model is highest. SST k-ω model takes the second place. Standard k-ω model can be used for the numerical simulation in the low specific speed centrifugal pump.

Centrifugal Pump Monitoring and Determination of Pump Characteristic Curves Using Experimental and Analytical Solutions

Directory of Open Access Journals (Sweden)

Marius Stan

2018-02-01

Full Text Available Centrifugal pumps are widely used in the industry, especially in the oil and gas sector for fluids transport. Classically, these are designed to transfer single phase fluids (e.g., water at high flow rates and relatively low pressures when compared with other pump types. As part of their constructive feature, centrifugal pumps rely on seals to prevent air entrapment into the rotor during its normal operation. Although this is a constructive feature, water should pass through the pump inlet even when the inlet manifold is damaged. Modern pumps are integrated in pumping units which consist of a drive (normally electric motor, a transmission (when needed, an electronic package (for monitoring and control, and the pump itself. The unit also has intake and outlet manifolds equipped with valves. Modern systems also include electronic components to measure and monitor pump working parameters such as pressure, temperature, etc. Equipment monitoring devices (vibration sensors, microphones are installed on modern pumping units to help users evaluate the state of the machinery and detect deviations from the normal working condition. This paper addresses the influence of air-water two-phase mixture on the characteristic curve of a centrifugal pump; pump vibration in operation at various flow rates under these conditions; the possibilities of using the results of experimental investigations in the numerical simulations for design and training purposes, and the possibility of using vibration and sound analysis to detect changes in the equipment working condition. Conclusions show that vibration analysis provides accurate information about the pump’s functional state and the pumping process. Moreover, the acoustic emission also enables the evaluation of the pump status, but needs further improvements to better capture and isolate the usable sounds from the environment.

Roller and Centrifugal Pumps: A Retrospective Comparison of Bleeding Complications in Extracorporeal Membrane Oxygenation.

Science.gov (United States)

Halaweish, Ihab; Cole, Adam; Cooley, Elaine; Lynch, William R; Haft, Jonathan W

2015-01-01

Centrifugal pumps are increasingly used for extracorporeal membrane oxygenation (ECMO) rather than roller pumps. However, shear forces induced by these types of continuousflow pumps are associated with acquired von Willebrand factor deficiency and bleeding complications. This study was undertaken to compare adverse bleeding complications with the use of centrifugal and roller pumps in patients on prolonged ECMO support. The records of all adult ECMO patients from June 2002 to 2013 were retrospectively reviewed using the University of Michigan Health System database and the Extracorporeal Life Support Organization registry, focusing on patients supported for at least 5 days. Ninety-five ECMO patients met criteria for inclusion (48 roller vs. 47 centrifugal pump). Indications included pulmonary (79%), cardiac (15%), and extracorporeal cardiopulmonary resuscitation (6%), without significant difference between the two groups. Despite lower heparin anticoagulation (10.9 vs. 13.7 IU/kg/hr) with centrifugal pumps, there was a higher incidence of nonsurgical bleeding (gastrointestinal, pulmonary, and neurological) in centrifugal pump patients (26.1 vs. 9.0 events/1,000 patient-days, p = 0.024). In conclusion, in our historical comparison, despite reduced anticoagulation, ECMO support using centrifugal pumps was associated with a higher incidence of nonsurgical bleeding. The mechanisms behind this are multifactorial and require further investigation.

An alternative arrangement of metered dosing fluid using centrifugal pump

Science.gov (United States)

Islam, Md. Arafat; Ehsan, Md.

2017-06-01

Positive displacement dosing pumps are extensively used in various types of process industries. They are widely used for metering small flow rates of a dosing fluid into a main flow. High head and low controllable flow rates make these pumps suitable for industrial flow metering applications. However their pulsating flow is not very suitable for proper mixing of fluids and they are relatively more expensive to buy and maintain. Considering such problems, alternative techniques to control the fluid flow from a low cost centrifugal pump is practiced. These include - throttling, variable speed drive, impeller geometry control and bypass control. Variable speed drive and impeller geometry control are comparatively costly and the flow control by throttling is not an energy efficient process. In this study an arrangement of metered dosing flow was developed using a typical low cost centrifugal pump using bypass flow technique. Using bypass flow control technique a wide range of metered dosing flows under a range of heads were attained using fixed pump geometry and drive speed. The bulk flow returning from the system into the main tank ensures better mixing which may eliminate the need of separate agitators. Comparative performance study was made between the bypass flow control arrangement of centrifugal pump and a diaphragm type dosing pump. Similar heads and flow rates were attainable using the bypass control system compared to the diaphragm dosing pump, but using relatively more energy. Geometrical optimization of the centrifugal pump impeller was further carried out to make the bypass flow arrangement more energy efficient. Although both the systems run at low overall efficiencies but the capital cost could be reduced by about 87% compared to the dosing pump. The savings in capital investment and lower maintenance cost very significantly exceeds the relatively higher energy cost of the bypass system. This technique can be used as a cost effective solution for

Development of liquid nitrogen Centrifugal Pump

International Nuclear Information System (INIS)

Abe, M; Sagiyama, R; Tsuchiya, H; Takayama, T; Torii, Y; Nakamura, M; Hoshino, Y; Odashima, Y

2009-01-01

Usually liquid nitrogen (LN 2 ) transfer from a container to a laboratory equipment takes place by applying pressure to the container to push out liquid or pouring liquid into the cryostat directly by lifting the container. In order to overcome inconvenience of pressuring or lifting containers, we have been developing the Liquid Nitrogen Centrifugal Pump of a small electric turbine pump. Significant advantages that both reducing time to fill LN 2 and controlling the flow rate of liquid into the cryostat are obtained by introducing this pump. We have achieved the lift of about 800mm with the vessel's opening diameter of 28mm.

Numerical simulation of flow in centrifugal pump under cavitation and sediment condition

International Nuclear Information System (INIS)

Lu, J L; Guo, P C; Zheng, X B; Zhao, Q; Luo, X Q

2012-01-01

The sediment concentration is very high in many rivers in the world, especially in China. The pumps that designed for the clear water are usually seriously abraded. The probability of pump cavitation is greatly enhanced due to the existence of sand. Under the joint action and mutual promotion of sand erosion and cavitation, serious abrasion could occurred, and the hydraulic performance of the pump may be greatly descended, meanwhile the safety and stability of the whole pump are greatly threatened. Therefore, it is significant to investigate the cavitation characteristic of pump under sediment flow condition. In this paper, the flow in a single stage centrifugal pump under cleat water and sediment flow conditions was numerically simulated. The cavitation performance under clear water was firstly analyzed. Then, The pressure, velocity and solid particle distribution in centrifugal pump under different particle diameter and different particle concentration was investigated by using the two-fluid model; The area and extent of erosion was illustrated by using the particle track model. Finally, the influence of mixed sand on centrifugal pump performance was investigated.

Influence of the positive prewhirl on the performance of centrifugal pumps with different airfoils

International Nuclear Information System (INIS)

Zhou, C M; Wang, H M; Huang, X; Lin, H

2012-01-01

According to the basic theory of turbomachinery design and inlet guide vanes prewhirl regulation, two different airfoils inlet guide vanes of prewhirl regulation device were designed, the influence of the positive prewhirl to the performance of centrifugal pump were studied based on different airfoils. The results show that, for a single-suction centrifugal pump: Gottingen bowed blade-type inlet guide vane adjustment effect is better than straight blade-type inlet guide; appropriate design of positive prewhirl can elevate the efficiency of centrifugal pumps. Compared with no vane conditions, the efficiency of centrifugal pump with prewhirl vanes has been greatly improved and the power consumption has been reduced significantly, while has little influence on the head.

High-efficiency design optimization of a centrifugal pump

Energy Technology Data Exchange (ETDEWEB)

Heo, Man Woong; Ma, Sang Bum; Shim, Hyeon Seok; Kim, Kwang Yong [Dept. of Mechanical Engineering, Inha University, Incheon (Korea, Republic of)

2016-09-15

Design optimization of a backward-curved blades centrifugal pump with specific speed of 150 has been performed to improve hydraulic performance of the pump using surrogate modeling and three-dimensional steady Reynolds-averaged Navier-Stokes analysis. The shear stress transport model was used for the analysis of turbulence. Four geometric variables defining the blade hub inlet angle, hub contours, blade outlet angle, and blade angle profile of impeller were selected as design variables, and total efficiency of the pump at design flow rate was set as the objective function for the optimization. Thirty-six design points were chosen using the Latin hypercube sampling, and three different surrogate models were constructed using the objective function values calculated at these design points. The optimal point was searched from the constructed surrogate model by using sequential quadratic programming. The optimum designs of the centrifugal pump predicted by the surrogate models show considerable increases in efficiency compared to a reference design. Performance of the best optimum design was validated compared to experimental data for total efficiency and head.

Blade design loads on the flow exciting force in centrifugal pump

International Nuclear Information System (INIS)

Xu, Y; Yang, A L; Langand, D P; Dai, R

2012-01-01

The three-dimensional viscous flow field of two centrifugal pumps, which have the same volute, design head, design flow rate and rotational speed but the blade design load, are analyzed based on large eddy simulation. The comparisons are implemented including the hydraulic efficiencies, flow field characteristics, pressure pulsations and unsteady forces applied on the impellers to investigate the effect of the design blade load on hydraulic performance and flow exciting force. The numerical results show that the efficiency of the pump, the impeller blade of which has larger design load, is improved by 1.1%∼2.9% compared to the centrifugal pump with lower blade design load. The pressure fluctuation of the pump with high design load is more remarkable. Its maximum amplitude of coefficient of static pressure is higher by 43% than the latter. At the same time the amplitude of unsteady radial force is increased by 11.6% in the time domain. The results also imply that the blade design load is an important factor on the excitation force in centrifugal pumps.

Development of a disposable maglev centrifugal blood pump intended for one-month support in bridge-to-bridge applications: in vitro and initial in vivo evaluation.

Science.gov (United States)

Someya, Takeshi; Kobayashi, Mariko; Waguri, Satoshi; Ushiyama, Tomohiro; Nagaoka, Eiki; Hijikata, Wataru; Shinshi, Tadahiko; Arai, Hirokuni; Takatani, Setsuo

2009-09-01

MedTech Dispo, a disposable maglev centrifugal blood pump with two degrees of freedom magnetic suspension and radial magnetic coupling rotation, has been developed for 1-month extracorporeal circulatory support. As the first stage of a two-stage in vivo evaluation, 2-week evaluation of a prototype MedTech Dispo was conducted. In in vitro study, the pump could produce 5 L/min against 800 mm Hg and the normalized index of hemolysis was 0.0054 +/- 0.0008 g/100 L. In in vivo study, the pump, with its blood-contacting surface coated with biocompatible 2-methacryloyloxyethyl phosphorylcholine polymer, was implanted in seven calves in left heart bypass. Pump performance was stable with a mean flow of 4.49 +/- 0.38 L/min at a mean speed of 2072.1 +/- 64.5 rpm. The maglev control revealed its stability in rotor position during normal activity by the calves. During 2 weeks of operation in two calves which survived the intended study period, no thrombus formation was seen inside the pump and levels of plasma free hemoglobin were maintained below 4 mg/dL. Although further experiments are required, the pump demonstrated the potential for sufficient and reliable performance and biocompatibility in meeting the requirements for cardiopulmonary bypass and 1-week circulatory support.

Performance Optimization of Centrifugal Pump for Crude Oil Delivery

Directory of Open Access Journals (Sweden)

S.A.I. Bellary

2018-02-01

Full Text Available Crude oil transport is an essential task in oil and gas industries, where centrifugal pumps are extensively used. The design of a centrifugal pump involves a number of independent parameters which affect the pump performance. Altering some of the parameters within a realistic range improves pump performance and saves a significant amount of energy. The present research investigated the pump characteristics by modifying the number of blades and the exit blade-angles. Reynolds-Averaged Navier-Stokes equations with standard k-ε two-equation turbulence closure were used for steady and incompressible flow of crude oil through the pump. The experimental set-up was installed and the pump performance calculated numerically  was compared with the experiments.   The investigations showed that the number of blades and the exit blade-angles have a significant influence on the head, shaft power, and efficiency. The vortical flow structures, recirculation and reverse flow characteristics around the impeller were investigated to explain the flow dynamics of impeller and casing. A larger number of blades on the rotor showed dominant streamlined flow without any wake phenomena. The combined effect of the number of blades and exit blade angle has led to an increase in head and efficiency through the parametric optimization.

High efficiency, variable geometry, centrifugal cryogenic pump

International Nuclear Information System (INIS)

Forsha, M.D.; Nichols, K.E.; Beale, C.A.

1994-01-01

A centrifugal cryogenic pump has been developed which has a basic design that is rugged and reliable with variable speed and variable geometry features that achieve high pump efficiency over a wide range of head-flow conditions. The pump uses a sealless design and rolling element bearings to achieve high reliability and the ruggedness to withstand liquid-vapor slugging. The pump can meet a wide range of variable head, off-design flow requirements and maintain design point efficiency by adjusting the pump speed. The pump also has features that allow the impeller and diffuser blade heights to be adjusted. The adjustable height blades were intended to enhance the pump efficiency when it is operating at constant head, off-design flow rates. For small pumps, the adjustable height blades are not recommended. For larger pumps, they could provide off-design efficiency improvements. This pump was developed for supercritical helium service, but the design is well suited to any cryogenic application where high efficiency is required over a wide range of head-flow conditions

Effects of the number of inducer blades on the anti-cavitation characteristics and external performance of a centrifugal pump

International Nuclear Information System (INIS)

Guo, XiaoMei; Shi, GaoPing; Zhu, ZuChao; Cui, BaoLing

2016-01-01

Installing an inducer upstream of the main impeller is an effective approach for improving the anti-cavitation performance of a high speed centrifugal pump. For a high-speed centrifugal pump with an inducer, the number of inducer blades can affect its internal flow and external performance. We studied the manner in which the number of inducer blades can affect the anti-cavitation characteristics and external performance of a centrifugal pump. We first use the Rayleigh-Plesset equation and the mixture model to simulate the vapor liquid flow in a centrifugal pump with an inducer, and then predict its external performance. Finally, we tested the external performance of a centrifugal pump with 2-, 3- and 4-bladed inducers, respectively. The results show that the simulations of external performance in a centrifugal pump are in accordance with our experiments. Based on this, we obtained vapor volume fraction distributions for the inducer, the impeller, and in the corresponding whole flow parts. We discovered that the vapor volume fraction of a centrifugal pump with a 3- bladed inducer is less than that of a centrifugal pump with 2- or 4-bladed inducers, which means that a centrifugal pump with a 3-bladed inducer has a better external and anti-cavitation performance.

Investigation of CFD calculation method of a centrifugal pump with unshrouded impeller

Science.gov (United States)

Wu, Dazhuan; Yang, Shuai; Xu, Binjie; Liu, Qiaoling; Wu, Peng; Wang, Leqin

2014-03-01

Currently, relatively large errors are found in numerical results in some low-specific-speed centrifugal pumps with unshrouded impeller because the effect of clearances and holes are not accurately modeled. Establishing an accurate analytical model to improve performance prediction accuracy is therefore necessary. In this paper, a three-dimensional numerical simulation is conducted to predict the performance of a low-specific-speed centrifugal pump, and the modeling, numerical scheme, and turbulent selection methods are discussed. The pump performance is tested in a model pump test bench, and flow rate, head, power and efficiency of the pump are obtained. The effect of taking into consideration the back-out vane passage, clearance, and balance holes is analyzed by comparing it with experimental results, and the performance prediction methods are validated by experiments. The analysis results show that the pump performance can be accurately predicted by the improved method. Ignoring the back-out vane passage in the calculation model of unshrouded impeller is found to generate better numerical results. Further, the calculation model with the clearances and balance holes can obviously enhance the numerical accuracy. The application of disconnect interface can reduce meshing difficulty but increase the calculation error at the off-design operating point at the same time. Compared with the standard k-ɛ, renormalization group k-ɛ, and Spalart-Allmars models, the Realizable k-ɛ model demonstrates the fastest convergent speed and the highest precision for the unshrouded impeller flow simulation. The proposed modeling and numerical simulation methods can improve the performance prediction accuracy of the low-specific-speed centrifugal pumps, and the modeling method is especially suitable for the centrifugal pump with unshrouded impeller.

77 FR 65360 - Grant of Authority for Subzone Status (Centrifugal and Submersible Pumps); Auburn, NY

Science.gov (United States)

2012-10-26

... Status (Centrifugal and Submersible Pumps); Auburn, NY Pursuant to its authority under the Foreign-Trade... authority to establish a special-purpose subzone at the centrifugal and submersible pump manufacturing and... submersible pumps and related controllers at the Xylem Water Systems U.S.A., LLC, facilities located in Auburn...

Simulation model for centrifugal pump in flow networks based on internal characteristics

International Nuclear Information System (INIS)

Sun, Ji-Lin; Xue, Ruo-Jun; Peng, Min-Jun

2018-01-01

For the simulation of centrifugal pump in flow network system, in general three approaches can be used, the fitting model, the numerical method and the internal characteristics model. The fitting model is simple and rapid thus widely used. The numerical method can provide more detailed information in comparison with the fitting model, but increases implementation complexity and computational cost. In real-time simulations of flow networks, to simulate the condition out of the rated condition, especially for the volume flow rate, which the accuracy of fitting model is incredible, a new method for simulating centrifugal pumps was proposed in this research. The method based on the theory head and hydraulic loss in centrifugal pumps, and cavitation is also to be considered. The simulation results are verified with experimental benchmark data from an actual pump. The comparison confirms that the proposed method could fit the flow-head curves well, and the responses of main parameters in dynamic-state operations are consistent with theoretical analyses.

Experimental and numerical investigation of centrifugal pumps with asymmetric inflow conditions

Science.gov (United States)

Mittag, Sten; Gabi, Martin

2015-11-01

Most of the times pumps operate off best point states. Reasons are changes of operating conditions, modifications, pollution and wearout or erosion. As consequences non-rotational symmetric flows, transient operational conditions, increased risk of cavitation, decrease of efficiency and unpredictable wearout can appear. Especially construction components of centrifugal pumps, in particular intake elbows, contribute to this matter. Intake elbows causes additional losses and secondary flows, hence non-rotational velocity distributions as intake profile to the centrifugal pump. As a result the impeller vanes experience permanent changes of the intake flow angle and with it transient flow conditions in the blade channels. This paper presents the first results of a project, experimentally and numerically investigating the consequences of non-rotational inflow to leading edge flow conditions of a centrifugal pump. Therefore two pumpintake- elbow systems are compared, by only altering the intake elbow geometry: a common single bended 90° elbow and a numerically optimized elbow (improved regarding rotational symmetric inflow conditions and friction coefficient). The experiments are carried out, using time resolved stereoscopic PIV on a full acrylic pump with refractions index matched (RIM) working fluid. This allows transient investigations of the flow field simultaneously for all blade leading edges. Additional CFD results are validated and used to further support the investigation i.e. for comparing an analog pump system with ideal inflow conditions.

An Experimental Study of Cavitation Detection in a Centrifugal Pump Using Envelope Analysis

Science.gov (United States)

Tan, Chek Zin; Leong, M. Salman

Cavitation represents one of the most common faults in pumps and could potentially lead to a series of failure in mechanical seal, impeller, bearing, shaft, motor, etc. In this work, an experimental rig was setup to investigate cavitation detection using vibration envelope analysis method, and measured parameters included sound, pressure and flow rate for feasibility of cavitation detection. The experiment testing included 3 operating points of the centrifugal pump (B.E.P, 90% of B.E.P and 80% of B.E.P). Suction pressure of the centrifugal pump was decreased gradually until the inception point of cavitation. Vibration measurements were undertaken at various locations including casing, bearing, suction and discharge flange of the centrifugal pump. Comparisons of envelope spectrums under cavitating and non-cavitating conditions were presented. Envelope analysis was proven useful in detecting cavitation over the 3 testing conditions. During the normal operating condition, vibration peak synchronous to rotational speed was more pronounced. It was however during cavitation condition, the half order sub-harmonic vibration component was clearly evident in the envelope spectrums undertaken at all measurement locations except at the pump bearing. The possible explanation of the strong sub-harmonic (½ of BPF) during cavitation existence in the centrifugal pump was due to insufficient time for the bubbles to collapse completely before the end of the single cycle.

Estimation of changes in dynamic hydraulic force in a magnetically suspended centrifugal blood pump with transient computational fluid dynamics analysis.

Science.gov (United States)

Masuzawa, Toru; Ohta, Akiko; Tanaka, Nobuatu; Qian, Yi; Tsukiya, Tomonori

2009-01-01

The effect of the hydraulic force on magnetically levitated (maglev) pumps should be studied carefully to improve the suspension performance and the reliability of the pumps. A maglev centrifugal pump, developed at Ibaraki University, was modeled with 926 376 hexahedral elements for computational fluid dynamics (CFD) analyses. The pump has a fully open six-vane impeller with a diameter of 72.5 mm. A self-bearing motor suspends the impeller in the radial direction. The maximum pressure head and flow rate were 250 mmHg and 14 l/min, respectively. First, a steady-state analysis was performed using commercial code STAR-CD to confirm the model's suitability by comparing the results with the real pump performance. Second, transient analysis was performed to estimate the hydraulic force on the levitated impeller. The impeller was rotated in steps of 1 degrees using a sliding mesh. The force around the impeller was integrated at every step. The transient analysis revealed that the direction of the radial force changed dynamically as the vane's position changed relative to the outlet port during one circulation, and the magnitude of this force was about 1 N. The current maglev pump has sufficient performance to counteract this hydraulic force. Transient CFD analysis is not only useful for observing dynamic flow conditions in a centrifugal pump but is also effective for obtaining information about the levitation dynamics of a maglev pump.

Optimization of centrifugal pump cavitation performance based on CFD

International Nuclear Information System (INIS)

Xie, S F; Wang, Y; Liu, Z C; Zhu, Z T; Ning, C; Zhao, L F

2015-01-01

In order to further improve the cavitation performance of a centrifugal pump, slots on impeller blade near inlet were studied and six groups of hydraulic model were designed. Base on cavitating flow feature inside a centrifugal pump, bubble growth and implosion are calculated from the Rayleigh-Plesset equation which describes the dynamic behavior of spherical bubble and RNG κ-ε model was employed to simulate and analyze the internal two-phase flow of the model pump under the same conditions. The simulation results show that slots on blade near inlet could improve the cavitation performance and cavitation performance improvement of the second group was more obvious. Under the same conditions, the pressure on the back of blade near inlet was higher than the pressure on the back of unmodified blade near inlet, and energy distribution in the flow channel between the two blades was more uniform with a small change of head

Experiment of a centrifugal pump during changing speed operation

International Nuclear Information System (INIS)

Yuan, H J; Wu, Y L; Liu, S H; Shao, J

2012-01-01

In this paper, a method of changing rotational speed of impeller periodically as the pulsatile working condition is developed to realize pulse outputs both of flow discharge and of head for a centrifugal pump through experiment. The performance of the centrifugal pump under pulsatile working operation condition is measured which indicates this model pump could produce desired pulse flow under such condition. Flow patterns at four testing points under pulsatile conditions are obtained by means of the particle image velocimetry (PIV) technology both with laser induced fluorescence (LIF) particles and refractive index matched (RIM) fluid. Results of PIV measurement show the distributions of velocity, streamlines, and the principal Reynolds normal stress (PRNS). Under the design flow rate condition, the relative velocity in the blade channel distributes smoothly and decreases from inlet to exit. And at the impeller exit, the relative velocity is lower close to suction side than that near pressure side of blade in most of blade channels.

Centrifugal Pump Experiment for Chemical Engineering Undergraduates

Science.gov (United States)

Vanderslice, Nicholas; Oberto, Richard; Marrero, Thomas R.

2012-01-01

The purpose of this paper is to describe a Centrifugal Pump Experiment that provided an experiential learning experience to chemical engineering undergraduates at the University of Missouri in the spring of 2010 in the Unit Operations Laboratory course. Lab equipment was used by senior students with computer-based data and control technology. In…

Disposable MagLev centrifugal blood pump utilizing a cone-shaped impeller.

Science.gov (United States)

Hijikata, Wataru; Sobajima, Hideo; Shinshi, Tadahiko; Nagamine, Yasuyuki; Wada, Suguru; Takatani, Setsuo; Shimokohbe, Akira

2010-08-01

To enhance the durability and reduce the blood trauma of a conventional blood pump with a cone-shaped impeller, a magnetically levitated (MagLev) technology has been applied to the BioPump BPX-80 (Medtronic Biomedicus, Inc., Minneapolis, MN, USA), whose impeller is supported by a mechanical bearing. The MagLev BioPump (MagLev BP), which we have developed, has a cone-shaped impeller, the same as that used in the BPX-80. The suspension and driving system, which is comprised of two degrees of freedom, radial-controlled magnetic bearing, and a simply structured magnetic coupling, eliminates any physical contact between the impeller and the housing. To reduce both oscillation of the impeller and current in the coils, the magnetic bearing system utilizes repetitive and zero-power compensators. In this article, we present the design of the MagLev mechanism, measure the levitational accuracy of the impeller and pressure-flow curves (head-quantity [HQ] characteristics), and describe in vitro experiments designed to measure hemolysis. For the flow-induced hemolysis of the initial design to be reduced, the blood damage index was estimated by using computational fluid dynamics (CFD) analysis. Stable rotation of the impeller in a prototype MagLev BP from 0 to 2750 rpm was obtained, yielding a flow rate of 5 L/min against a head pressure in excess of 250 mm Hg. Because the impeller of the prototype MagLev BP is levitated without contact, the normalized index of hemolysis was 10% less than the equivalent value with the BPX-80. The results of the CFD analysis showed that the shape of the outlet and the width of the fluid clearances have a large effect on blood damage. The prototype MagLev BP satisfied the required HQ characteristics (5 L/min, 250 mm Hg) for extracorporeal circulation support with stable levitation of the impeller and showed an acceptable level of hemolysis. The simulation results of the CFD analysis indicated the possibility of further reducing the blood damage of

Cooling device for leaking fluid from a centrifugal pump

International Nuclear Information System (INIS)

Raymond, J.R.; Thomson, C.I.

1978-01-01

The patented device consists of an integrated heat exchanger in a centrifugal primary cooling circuit pump whose purpose is to cool the coolant medium which leaks along the pump shaft so that the shaft seals are not damaged. The cooling water passes through spirally arranged banks of tubes round the shaft, with baffle plates to direct the leaking coolant. (JIW)

Transformation of vibration signals in rotary blood pumps: the diagnostic potential of pump failure.

Science.gov (United States)

Kawahito, Koji

2013-09-01

Although non-destructive and continuous monitoring is indispensable for long-term circulatory support with rotary blood pumps, a practical monitoring system has not yet been developed. The objective of this study was to investigate the possibility of detecting pump failure caused by thrombus formation through the monitoring of vibration signals. The data acquisition equipment included vibration pickups, a charge amplifier, vibration analysis systems, and exclusive hardware. A pivot-bearing centrifugal pump with a mock circuit was investigated for vibration analysis. To simulate the four common areas of thrombus formation, we used a piece of silicon attached to each of the following four locations: the total area of the bottom of the impeller, an eccentric shape on the bottom of the impeller, a circular shape around the shaft top, and an eccentric shape on the top of the impeller. Vibration signals were picked up, and the power spectrum density analysis was performed at pump rotational speeds of 2100, 2400, and 3000 rpm. In this study, pump failure could be detected, and the types of imitation thrombi could be determined. We conclude that vibration detection with a computerized analysis system is a potentially valuable diagnostic tool for long-term circulatory support with rotary blood pumps.

Numerical investigation of a new LH2 centrifugal pump concept used in space propulsion

Directory of Open Access Journals (Sweden)

Ion MALAEL

2018-06-01

Full Text Available The present study deals with efficiency increase of a centrifugal pump for liquid rocket propulsion by using an innovative concept. With this new pump design the axial length will be reduced by 60% and 20% mass weight towards a classic two stage centrifugal pump. To estimate the performances, the CFD methods were used. The CFD analysis will be performed on 3D domains with the CFD commercial code ANSYS CFX. The numerical solvers used are pressure based with the SIMPLE method for RANS. The domain discretization was done by using dedicated grid generators like TurboGrid and ICEM CFD. The results were compared with a classic configuration with two stages in series. Centrifugal pump characteristics, such as pressure inlet-outlet variation, velocity and streamline patterns are presented in the paper.

Impeller inlet geometry effect on performance improvement for centrifugal pumps

International Nuclear Information System (INIS)

Luo, Xianwu; Zhang, Yao; Peng, Junqi; Xu, Hongyuan; Yu, Weiping

2008-01-01

This research treats the effect of impeller inlet geometry on performance improvement for a boiler feed pump, who is a centrifugal pump having specific speed of 183 m.m 3 min -1 .min -1 and close type impeller with exit diameter of 450 mm. The hydraulic performance and cavitation performance of the pump have been tested experimentally. In order to improve the pump, five impellers have been considered by extending the blade leading edge or applying much larger blade angle at impeller inlet compared with the original impeller. The 3-D turbulent flow inside those pumps has been analyzed basing on RNG k-ε turbulence model and VOF cavitation model. It is noted that the numerical results are fairly good compared with the experiments. Based on the experimental test and numerical simulation, the following conclusions can be drawn: (1) Impeller inlet geometry has important influence on performance improvement in the case of centrifugal pump. Favorite effects on performance improvement have been achieved by both extending the blade leading edge and applying much larger blade angle at impeller inlet: (2) It is suspected that the extended leading edge have favorite effect for improving hydraulic performance, and the much larger blade angle at impeller inlet have favorite effect for improving cavitation performance for the test pump: (3) Uniform flow upstream of impeller inlet is helpful for improving cavitation performance of the pump

Numerical prediction and performance experiment in a deep-well centrifugal pump with different impeller outlet width

Science.gov (United States)

Shi, Weidong; Zhou, Ling; Lu, Weigang; Pei, Bing; Lang, Tao

2013-01-01

The existing research of the deep-well centrifugal pump mainly focuses on reduce the manufacturing cost and improve the pump performance, and how to combine above two aspects together is the most difficult and important topic. In this study, the performances of the deep-well centrifugal pump with four different impeller outlet widths are studied by the numerical, theoretical and experimental methods in this paper. Two stages deep-well centrifugal pump equipped with different impellers are simulated employing the commercial CFD software to solve the Navier-Stokes equations for three-dimensional incompressible steady flow. The sensitivity analyses of the grid size and turbulence model have been performed to improve numerical accuracy. The flow field distributions are acquired and compared under the design operating conditions, including the static pressure, turbulence kinetic energy and velocity. The prototype is manufactured and tested to certify the numerical predicted performance. The numerical results of pump performance are higher than the test results, but their change trends have an acceptable agreement with each other. The performance results indicted that the oversize impeller outlet width leads to poor pump performances and increasing shaft power. Changing the performance of deep-well centrifugal pump by alter impeller outlet width is practicable and convenient, which is worth popularizing in the engineering application. The proposed research enhances the theoretical basis of pump design to improve the performance and reduce the manufacturing cost of deep-well centrifugal pump.

Diagnosis of Centrifugal Pump Faults Using Vibration Methods

International Nuclear Information System (INIS)

Albraik, A; Althobiani, F; Gu, F; Ball, A

2012-01-01

Pumps are the largest single consumer of power in industry. This means that faulty pumps cause a high rate of energy loss with associated performance degradation, high vibration levels and significant noise radiation. This paper investigates the correlations between pump performance parameters including head, flow rate and energy consumption and surface vibration for the purpose of both pump condition monitoring and performance assessment. Using an in-house pump system, a number of experiments have been carried out on a centrifugal pump system using five impellers: one in good condition and four others with different defects, and at different flow rates for the comparison purposes. The results have shown that each defective impeller performance curve (showing flow, head, efficiency and NPSH (Net Positive Suction Head) is different from the benchmark curve showing the performance of the impeller in good condition. The exterior vibration responses were investigated to extract several key features to represent the healthy pump condition, pump operating condition and pump energy consumption. In combination, these parameter allow an optimal decision for pump overhaul to be made.

Diagnosis of Centrifugal Pump Faults Using Vibration Methods

Science.gov (United States)

Albraik, A.; Althobiani, F.; Gu, F.; Ball, A.

2012-05-01

Pumps are the largest single consumer of power in industry. This means that faulty pumps cause a high rate of energy loss with associated performance degradation, high vibration levels and significant noise radiation. This paper investigates the correlations between pump performance parameters including head, flow rate and energy consumption and surface vibration for the purpose of both pump condition monitoring and performance assessment. Using an in-house pump system, a number of experiments have been carried out on a centrifugal pump system using five impellers: one in good condition and four others with different defects, and at different flow rates for the comparison purposes. The results have shown that each defective impeller performance curve (showing flow, head, efficiency and NPSH (Net Positive Suction Head) is different from the benchmark curve showing the performance of the impeller in good condition. The exterior vibration responses were investigated to extract several key features to represent the healthy pump condition, pump operating condition and pump energy consumption. In combination, these parameter allow an optimal decision for pump overhaul to be made [1].

Hemolytic performance of a MagLev disposable rotary blood pump (MedTech Dispo): effects of MagLev gap clearance and surface roughness.

Science.gov (United States)

Hoshi, Hideo; Asama, Junichi; Hijikata, Wataru; Hara, Chikara; Shinshi, Tadahiko; Yasuda, Toshitaka; Ohuchi, Katsuhiro; Shimokohbe, Akira; Takatani, Setsuo

2006-12-01

Mechanical shaft seal bearing incorporated in the centrifugal blood pumps contributes to hemolysis and thrombus formation. In addition, the problem of durability and corrosion of mechanical shaft seal bearing has been recently reported from the safety point of view. To amend the shortcomings of the blood-immersed mechanical bearings, a magnetic levitated centrifugal rotary blood pump (MedTech Dispo Model 1; Tokyo Medical and Dental University, Tokyo, Japan) has been developed for extracorporeal disposable application. In this study, the hemolytic performance of the MedTech Dispo Model 1 centrifugal blood pump system was evaluated, with special focus on the narrow blood path clearance at the magnetic bearing between rotor and stator, and on the pump housing surface roughness. A pump flow of 5 L/min against the head pressure of 100 mm Hg for 4 h was included in the hemolytic test conditions. Anticoagulated fresh porcine blood was used as a working fluid. The clearance of blood path at the magnetic bearing was in the range of 100-250 micro m. Pump housing surface roughness was controlled to be around Ra = 0.1-1.5 micro m. The lowest hemolytic results were obtained at the clearance of 250 micro m and with the polished surface (Ra = 0.1 micro m) yielding the normalized index of hemolysis (NIH) of less than 0.001 g/100 L, which was 1/5 of the Biopump BP-80 (Medtronic Inc., Minneapolis, MN, USA, and 1/4 of the BPX-80. In spite of rough surface and narrow blood path, NIH levels were less than clinically acceptable level of 0.005 g/100 L. The noncontact, levitated impeller system is useful to improve pump performance in blood environment.

Research of fluid-induced pressure fluctuation due to impeller-volute interaction in a centrifugal pump

International Nuclear Information System (INIS)

Liu, Q Z; Yang, K; Li, D Y; Gong, R Z

2013-01-01

The fluid pressure fluctuation generated by unsteady flow is a very important factor to induce vibration of the centrifugal pump. The relative movement between impeller and volute generates an unsteady interaction which affects not only the overall pump performance, but is also responsible for pressure fluctuations. Pressure fluctuations interact with the volute casing or even with the circuit and give rise to dynamic effects over the mechanical parts, which are one of the most important sources of vibration and hydraulic noise. To investigate the flow characteristic in the centrifugal pump, the unsteady flow is simulated by CFD methods in this paper. Unsteady flow characteristic in the centrifugal pump is obtained considering the impeller-volute interaction in the whole flow field. Based on the unsteady flow simulation, amplitude-frequency characteristics of the pressure fluctuation in the centrifugal pump are obtained through setting up monitoring point at the impeller outlet. The research shows that the frequency component include the blade passing frequency as the main component, the multiplication of blade passing frequency, and the harmonic interference due to the unsteady flow

Improvement of centrifugal pump performance through addition of splitter blades on impeller pump

Science.gov (United States)

Kurniawan, Krisna Eka; Santoso, Budi; Tjahjana, Dominicus Danardono Dwi Prija

2018-02-01

The workable way to improve pump performance is to redesign or modify the impellers of centrifugal pump. The purpose of impeller pump modification is to improve pump efficiency, reduce cross flow, reduce secondary incidence flows, and decrease backflow areas at impeller outlets. Number blades and splitter blades in the impeller are three. The outlet blade angle is 20°, and the rotating speed of impeller is 2400 rpm. The added splitter blades variations are 0.25, 0.375, and 0.5 of the original blade length. The splitter blade placements are on the outer side of the impeller. The addition of splitter blades on the outer side of the impeller with 0.5L increases the pump head until 22% and the pump has 38.66% hydraulic efficiency. The best efficiency point of water flow rate pump (Qbep) was 3.02 × 10-3 m3/s.

2011 IEEE Visualization Contest Winner: Visualizing Unsteady Vortical Behavior of a Centrifugal Pump

KAUST Repository

Otto, Mathias

2012-09-01

In the 2011 IEEE Visualization Contest, the dataset represented a high-resolution simulation of a centrifugal pump operating below optimal speed. The goal was to find suitable visualization techniques to identify regions of rotating stall that impede the pump\\'s effectiveness. The winning entry split analysis of the pump into three parts based on the pump\\'s functional behavior. It then applied local and integration-based methods to communicate the unsteady flow behavior in different regions of the dataset. This research formed the basis for a comparison of common vortex extractors and more recent methods. In particular, integration-based methods (separation measures, accumulated scalar fields, particle path lines, and advection textures) are well suited to capture the complex time-dependent flow behavior. This video (http://youtu.be/ oD7QuabY0oU) shows simulations of unsteady flow in a centrifugal pump. © 2012 IEEE.

Impeller inlet geometry effect on performance improvement for centrifugal pumps

Energy Technology Data Exchange (ETDEWEB)

Luo, Xianwu; Zhang, Yao; Peng, Junqi; Xu, Hongyuan [Tsinghua University, Beijing (China); Yu, Weiping [Zhejiang Pump Works, Zhejiang (China)

2008-10-15

This research treats the effect of impeller inlet geometry on performance improvement for a boiler feed pump, who is a centrifugal pump having specific speed of 183 m.m{sup 3}min{sup -1}.min{sup -1} and close type impeller with exit diameter of 450 mm. The hydraulic performance and cavitation performance of the pump have been tested experimentally. In order to improve the pump, five impellers have been considered by extending the blade leading edge or applying much larger blade angle at impeller inlet compared with the original impeller. The 3-D turbulent flow inside those pumps has been analyzed basing on RNG k-{epsilon} turbulence model and VOF cavitation model. It is noted that the numerical results are fairly good compared with the experiments. Based on the experimental test and numerical simulation, the following conclusions can be drawn: (1) Impeller inlet geometry has important influence on performance improvement in the case of centrifugal pump. Favorite effects on performance improvement have been achieved by both extending the blade leading edge and applying much larger blade angle at impeller inlet: (2) It is suspected that the extended leading edge have favorite effect for improving hydraulic performance, and the much larger blade angle at impeller inlet have favorite effect for improving cavitation performance for the test pump: (3) Uniform flow upstream of impeller inlet is helpful for improving cavitation performance of the pump

Hydraulic performance of a low specific speed centrifugal pump with Spanwise-Slotted Blades

International Nuclear Information System (INIS)

Ye, D X; Li, H; Wang, Y

2013-01-01

The hydraulic efficiency of a low specific speed centrifugal pump is low because of the long and narrow meridian flow passage, and the severe disk friction. Spanwise slotted blade flow control technology has been applied to the low specific speed centrifugal pump. This paper concluded that spanwise slotted blades can improve the pump performance in both experiments and simulations. In order to study the influence to the impeller and volute by spanwise slotted blade, impeller efficiency and volute efficiency were defined. The minimum volute efficiency and the maximum pump efficiency appear at the same time in the design flow condition in the unsteady simulation. The mechanism of spanwise slotted blade flow control technology should be researched furthermore

Development of a disposable magnetically levitated centrifugal blood pump (MedTech Dispo) intended for bridge-to-bridge applications--two-week in vivo evaluation.

Science.gov (United States)

Nagaoka, Eiki; Someya, Takeshi; Kitao, Takashi; Kimura, Taro; Ushiyama, Tomohiro; Hijikata, Wataru; Shinshi, Tadahiko; Arai, Hirokuni; Takatani, Setsuo

2010-09-01

Last year, we reported in vitro pump performance, low hemolytic characteristics, and initial in vivo evaluation of a disposable, magnetically levitated centrifugal blood pump, MedTech Dispo. As the first phase of the two-stage in vivo studies, in this study we have carried out a 2-week in vivo evaluation in calves. Male Holstein calves with body weight of 62.4–92.2 kg were used. Under general anesthesia, a left heart bypass with a MedTech Dispo pump was instituted between the left atrium and the descending aorta via left thoracotomy. Blood-contacting surface of the pump was coated with a 2-methacryloyloxyethyl phosphorylcholine polymer. Post-operatively, with activated clotting time controlled at 180–220 s using heparin and bypass flow rate maintained at 50 mL/kg/min, plasma-free hemoglobin (Hb), coagulation, and major organ functions were analyzed for evaluation of biocompatibility. The animals were electively sacrificed at the completion of the 2-week study to evaluate presence of thrombus inside the pump,together with an examination of major organs. To date, we have done 13 MedTech Dispo implantations, of which three went successfully for a 2-week duration. In these three cases, the pump produced a fairly constant flow of 50 mL/Kg/min. Neurological disorders and any symptoms of thromboembolism were not seen. Levels of plasma-free Hb were maintained very low. Major organ functions remained within normal ranges. Autopsy results revealed no thrombus formation inside the pump. In the last six cases, calves suffered from severe pneumonia and they were excluded from the analysis. The MedTech Dispo pump demonstrated sufficient pump performance and biocompatibility to meet requirements for 1-week circulatory support. The second phase (2-month in vivo study) is under way to prove the safety and efficacy of MedTech Dispo for 1-month applications. © 2010, Copyright the Authors. Artificial Organs © 2010, International Center for Artificial Organs and Transplantation

THEORETICAL FLOW MODEL THROUGH A CENTRIFUGAL PUMP USED FOR WATER SUPPLY IN AGRICULTURE IRRIGATION

Directory of Open Access Journals (Sweden)

SCHEAUA Fanel Dorel

2017-05-01

motion of the rotor. A theoretical model for calculating the flow of the working fluid through the interior of a centrifugal pump model is presented in this paper as well as the numerical analysis on the virtual model performed with the ANSYS CFX software in order to highlight the flow parameters and flow path-lines that are formed during centrifugal pump operation.

Numerical simulation and analysis of cavitation flows in a double suction centrifugal pump

International Nuclear Information System (INIS)

Meng, G; Tan, L; Cao, S L; Jian, W; Liu, W W; Jiang, D J

2015-01-01

Cavitation is an unsteady phenomenon, which is nearly inevitable in pumps. It would degrade the pump performance, generate vibrations and noises, and even erode pump flow passage components. The double suction centrifugal pump at design flow rate and large flow rate is numerically simulated using the k-ω turbulence model and the mass transport cavitation model. As a result, the calculated variation of pump head with pump inlet pressure agreed well with the experimental data. The results demonstrate that the numerical model and method can accurately predict the cavitation flows in a double suction centrifugal pump. The cavitation characteristics are analysed in great details. In addition, based on the calculation results, the reason that the plunge of pump head curve is revealed. It is found that the steep fall of pump head happens when the cavity reaches the blade to blade throat and the micro-vortex group appears at the back of the blade suction side. At the same time, this practice can provide guidance for the optimal design of double suction pumps

A study on the performance and internal flow characteristics of a very low specific speed centrifugal pump

International Nuclear Information System (INIS)

Choi, Young Do; Kurokawa, Junichi; Lee, Young Ho

2005-01-01

In the very low specific speed range (n s < 0.25, non-dimensional), the efficiency of centrifugal pump designed by a conventional method is very low in common. Therefore, positive-displacement pumps have long been used widely. Recently, since the centrifugal pumps are becoming higher in rotational speed and smaller in size, there experts to develop a new centrifugal pump with a high performance to replace the positive-displacement pumps. The purpose of this study is to investigate the internal flow characteristics of a very low specific speed centrifugal pump and to examine the effect of internal flow pattern on pump performance. The results show that the theoretical head definition of semi-open impeller should be revised by the consideration of high slip factor in the semi-open impeller, and the leakage flow through the tip clearance results in a large effect on the impeller internal flow. Strong reverse flow at the outlet of semi-open impeller reduces the absolute tangential velocity considerably, and the decreased absolute tangential velocity increases the slip factor with the reduction of theoretical head

Investigation on Flow-Induced Noise due to Backflow in Low Specific Speed Centrifugal Pumps

Directory of Open Access Journals (Sweden)

Qiaorui Si

2013-01-01

Full Text Available Flow-induced noise causes disturbances during the operation of centrifugal pumps and also affects their performance. The pumps often work at off-design conditions, mainly at part-load conditions, because of frequent changes in the pump device system. Consequently numerous unstable phenomena occur. In low specific speed centrifugal pumps the main disturbance is the inlet backflow, which is considered as one of the most important factors of flow-induced noise and vibration. In this study, a test rig of the flow-induced noise and vibration of the centrifugal pump was built to collect signals under various operating conditions. The three-dimensional unsteady flow of centrifugal pumps was calculated based on the Reynolds-averaged equations that resemble the shear stress transport (SST k-ω turbulence model. The results show that the blade passing frequency and shaft frequency are dominant in the spectrum of flow-induced noise, whereas the shaft component, amplitude value at shaft frequency, and peak frequencies around the shaft increase with decreasing flow. Through flow field analysis, the inlet backflow of the impeller occurs under 0.7 times the design flow. The pressure pulsation spectrum with backflow conditions validates the flow-induced noise findings. The velocity characteristics of the backflow zone at the inlet pipe were analyzed, and the dynamic characteristics of the backflow eddy during one impeller rotating period were simultaneously obtained by employing the backflow conditions. A flow visualization experiment was performed to confirm the numerical calculations.

Active magnetic bearings: As applied to centrifugal pumps

Science.gov (United States)

Nelik, Lev; Cooper, Paul; Jones, Graham; Galecki, Dennis; Pinckney, Frank; Kirk, Gordon

1992-05-01

Application of magnetic bearings to boiler feed pumps presents various attractive features, such as longer bearing life, lower maintenance costs, and improved operability through control of the rotordynamics. Magnetic bearings were fitted to an eight-stage, 600 hp boiler feed pump, which generates 2600 ft of heat at 680 gpm and 3560 rpm. In addition to the varied and severe operating environment in steady state operation of this pump in a power plant, it is also subjected to transient loads during frequent starts and stops. These loads can now be measured by the in-built instrumentation of the magnetic bearings. Following site installation, a follow-up bearing tune-up was performed, and pump transient response testing was conducted. The bearing response was completely satisfactory, ensuring trouble-free pump operation even in the range of reduced load. The experience gained so far through design and testing proves feasibility of magnetic bearings for boiler feed pumps, which sets the stage for application of even higher energy centrifugal pumps equipped with magnetic bearings.

Centrifugal pumping during Czochralski silicon growth with a strong, non-uniform, axisymmetric magnetic field

Science.gov (United States)

Khine, Y. Y.; Walker, J. S.

1996-08-01

Centrifugal pumping flows are produced in the melt by the rotations of crystal and crucible during the Czochralski growth of silicon crystals. This paper treats the centrifugal pumping effects with a steady, strong, non-uniform axisymmetric magnetic field. We consider a family of magnetic fields ranging from a uniform axial field to a "cusp" field, which has a purely radial field at the crystal-melt interface and free surface. We present the numerical solutions for the centrifugal pumping flows as the magnetic field is changed continuously from a uniform axial field to a cusp one, and for arbitrary Hartmann number. Since the perfect alignment between the local magnetic field vector and the crystal-melt interface or free surface is not likely, we also investigate the effects of a slight misalignment.

Model Based Fault Detection in a Centrifugal Pump Application

DEFF Research Database (Denmark)

Kallesøe, Carsten; Cocquempot, Vincent; Izadi-Zamanabadi, Roozbeh

2006-01-01

A model based approach for fault detection in a centrifugal pump, driven by an induction motor, is proposed in this paper. The fault detection algorithm is derived using a combination of structural analysis, observer design and Analytical Redundancy Relation (ARR) design. Structural considerations...

2011 IEEE Visualization Contest winner: Visualizing unsteady vortical behavior of a centrifugal pump.

Science.gov (United States)

Otto, Mathias; Kuhn, Alexander; Engelke, Wito; Theisel, Holger

2012-01-01

In the 2011 IEEE Visualization Contest, the dataset represented a high-resolution simulation of a centrifugal pump operating below optimal speed. The goal was to find suitable visualization techniques to identify regions of rotating stall that impede the pump's effectiveness. The winning entry split analysis of the pump into three parts based on the pump's functional behavior. It then applied local and integration-based methods to communicate the unsteady flow behavior in different regions of the dataset. This research formed the basis for a comparison of common vortex extractors and more recent methods. In particular, integration-based methods (separation measures, accumulated scalar fields, particle path lines, and advection textures) are well suited to capture the complex time-dependent flow behavior. This video (http://youtu.be/oD7QuabY0oU) shows simulations of unsteady flow in a centrifugal pump.

CENTRIFUGE APPARATUS

Science.gov (United States)

Skarstrom, C.; Urey, H.C.; Cohen, K.

1960-08-01

A high-speed centrifuge for the separation of gaseous isotopes is designed comprising a centrifugal pump mounted on the outlet of a centrifuge bowl and arranged to pump the heavy and light fractions out of the centrifuge bowl in two separate streams.

Rotordynamic Forces on Centrifugal Pump Impellers

OpenAIRE

Franz, R.; Arndt, N.; Caughey, T. K.; Brennen, C. E.; Acosta, A. J.

1987-01-01

The asymmetric flow around an impeller in a volute exerts a force upon the impeller. To study the rotordynamic force on an impeller which is vibrating around its machine axis of rotation, the impeller, mounted on a dynamometer, is made to whirl in a circular orbit within the volute. The measured force is expressed as the sum of a steady radial force and an unsteady force due to the eccentric motion of the impeller. These forces were measured in separate tests on a centrifugal pump with rad...

Container for centrifuging blood

International Nuclear Information System (INIS)

Narra, R.K.

1982-01-01

A container is described for use in drawing patient's blood, centrifuging the blood and then labelling the separated red cells with sup(99m)Tc. It consists of a tube with a central chamber and a lower portion provided with an aperture in which a weir is supported and extends into the central chamber. The weir has a central channel. A resilient plug seals the aperture. (author)

Variations in battery life of a heart-lung machine using different pump speeds, pressure loads, boot material, centrifugal pump head, multiple pump usage, and battery age.

LENUS (Irish Health Repository)

Marshall, Cornelius

2012-02-03

Electrical failure during cardiopulmonary bypass (CPB) has previously been reported to occur in 1 of every 1500 cases. Most heart-lung machine pump consoles are equipped with built-in battery back-up units. Battery run times of these devices are variable and have not been reported. Different conditions of use can extend battery life in the event of electrical failure. This study was designed to examine the run time of a fully charged battery under various conditions of pump speed, pressure loads, pump boot material, multiple pump usage, and battery life. Battery life using a centrifugal pump also was examined. The results of this study show that battery life is affected by pump speed, circuit pressure, boot stiffness, and the number of pumps in service. Centrifugal pumps also show a reduced drain on battery when compared with roller pumps. These elements affect the longevity and performance of the battery. This information could be of value to the individual during power failure as these are variables that can affect the battery life during such a challenging scenario.

Suppression of secondary flows in a double suction centrifugal pump with different loading distributions

International Nuclear Information System (INIS)

Leng, H F; Wang, F J; Zhang, Z C; Yao, Z F; Zhou, P J

2013-01-01

Secondary flow is one of the main reasons for low efficiency in double suction centrifugal pump. In a 3-D inverse design method, the pump blade could be designed by a specified loading distribution to control the flow field in pump. In order to study the influence of loading distribution on secondary flow of a double suction centrifugal pump, the external characteristics and the internal flow field of the pump with three kinds of loading distributions are analysed by using CFD approach. According to the simulation results, it is found that the form of fore-loading distribution at shroud and aft-loading distribution at hub could improve the optimal efficiency and broaden the high efficiency area of the pump. Furthermore, the secondary flow in impeller exit region and volute could be significantly suppressed if the slope of loading distribution curve of shroud is set to be −0.7

Exit loss model for plain axial seals in multi-stage centrifugal pumps

NARCIS (Netherlands)

Bruurs, K.A.J.; van Esch, B.P.M.; van der Schoot, M.S.

2017-01-01

Plain axial seals are often used in centrifugal pumps as a means to achieve acceptable sealing against leakage flow without the much higher friction losses that are associated with mechanical seals. Examples of their application are the front seals in shrouded radial and mixed-flow pumps and the

Centrifugal pumps and hemolysis in pediatric extracorporeal membrane oxygenation (ECMO) patients: An analysis of Extracorporeal Life Support Organization (ELSO) registry data.

Science.gov (United States)

O'Brien, Ciaran; Monteagudo, Julie; Schad, Christine; Cheung, Eva; Middlesworth, William

2017-06-01

It is currently unclear whether centrifugal pumps cause more hemolysis than roller pumps in extracorporeal membrane oxygenation (ECMO) circuits. The aim of this study was to help answer that question in pediatric patients. A limited deidentified data set was extracted from the international multicenter Extracorporeal Life Support Organization (ELSO) registry comprising all reported ECMO runs for patients 18years or younger between 2010 and 2015. Logistic regression was used to evaluate a possible association between hemolysis and pump type, controlling for patient demographics, circuit factors, and complications. 14,776 ECMO runs for 14,026 patients had pump type recorded. Centrifugal pumps were employed in 60.4% of ECMO circuits. Hemolysis was a reported complication for 1272 (14%) centrifugal pump runs and for 291 (5%) roller pump runs. 1755 (20%) centrifugal pump runs reported kidney injury as compared to 797 (14%) roller pump runs. In the full logistic regression, the odds of hemolysis were significantly greater for runs using centrifugal pumps (OR 3.3, 95% CI 2.9-3.8, ppumps was associated with increased rates of hemolysis, hyperbilirubinemia, and kidney injury. Retrospective cohort study. Level III. Copyright © 2017 Elsevier Inc. All rights reserved.

Analysis of cavitation behaviour in a centrifugal pump

International Nuclear Information System (INIS)

He, M; Zhou, L J; Guo, Q; Fu, L P; Wang, Z W

2012-01-01

Cavitation is a well-known problem in centrifugal pumps, causing serious damage and substantial head losses. However, the reason for the sudden head drop in cavitation curves is not fully understood. In this paper, the transient three-dimensional cavitating flow field in a centrifugal pump was calculated using RNG k-ε turbulence model and Rayleigh Plesset cavitation model. The NPSH-H curve and the cavitation development in the whole passage were predicted. The blade loading and energy transfer are analyzed for various cavitation conditions. The results show that the existing of the cavities changes the load distribution on blades. With the decrease of NPSH the loads on blades tend to increases in the rear part but decreases in the front part. If NPSH is not so low, sometimes the overall torque may increase slightly, thus the head may also increase slightly. But if the NPSH become low and reach a threshold value, the overall torque will also decrease. At the same time, the energy dissipation in the vortices increases greatly because of the growth of the cavities. These two reasons make the head drop rapidly.

Assessment of hydraulic performance and biocompatibility of a MagLev centrifugal pump system designed for pediatric cardiac or cardiopulmonary support.

Science.gov (United States)

Dasse, Kurt A; Gellman, Barry; Kameneva, Marina V; Woolley, Joshua R; Johnson, Carl A; Gempp, Thomas; Marks, John D; Kent, Stella; Koert, Andrew; Richardson, J Scott; Franklin, Steve; Snyder, Trevor A; Wearden, Peter; Wagner, William R; Gilbert, Richard J; Borovetz, Harvey S

2007-01-01

The treatment of children with life-threatening cardiac and cardiopulmonary failure is a large and underappreciated public health concern. We have previously shown that the CentriMag is a magnetically levitated centrifugal pump system, having the utility for treating adults and large children (1,500 utilized worldwide). We present here the PediVAS, a pump system whose design was modified from the CentriMag to meet the physiological requirements of young pediatric and neonatal patients. The PediVAS is comprised of a single-use centrifugal blood pump, reusable motor, and console, and is suitable for right ventricular assist device (RVAD), left ventricular assist device (LVAD), biventricular assist device (BVAD), or extracorporeal membrane oxygenator (ECMO) applications. It is designed to operate without bearings, seals and valves, and without regions of blood stasis, friction, or wear. The PediVAS pump is compatible with the CentriMag hardware, although the priming volume was reduced from 31 to 14 ml, and the port size reduced from 3/8 to (1/4) in. For the expected range of pediatric flow (0.3-3.0 L/min), the PediVAS exhibited superior hydraulic efficiency compared with the CentriMag. The PediVAS was evaluated in 14 pediatric animals for up to 30 days, demonstrating acceptable hydraulic function and hemocompatibility. The current results substantiate the performance and biocompatibility of the PediVAS cardiac assist system and are likely to support initiation of a US clinical trial in the future.

Investigation of the Flow Field and Performances of a Centrifugal Pump at Part Load

Science.gov (United States)

Prunières, R.; Inoue, Y.; Nagahara, T.

2016-11-01

Centrifugal pump performance curve instability, characterized by a local dent at part load, can be the consequence of flow instabilities in rotating or stationary parts. Such flow instabilities often result in abnormal operating conditions which can damage both the pump and the system. In order for the pump to have reliable operation over a wide flow rate range, it is necessary to achieve a design free of instability. The present paper focuses on performance curve instability of a centrifugal pump of mid specific speed (ωs = 0.65) for which instability was observed at part load during tests. The geometry used for this research consist of the first stage of a multi-stage centrifugal pump and is composed of a suction bend, a closed-type impeller, a vaned diffuser and return guide vanes. In order to analyse the instability phenomenon, PIV and CFD analysis were performed. Both methods qualitatively agree relatively well. It appears that the main difference before and after head drop is an increase of reverse flow rate at the diffuser passage inlet on the hub side. This reverse flow decreases the flow passing area at the diffuser passage inlet, disallowing effective flow deceleration and impairing static pressure recovery.

Application of two turbulence models for computation of cavitating flows in a centrifugal pump

International Nuclear Information System (INIS)

He, M; Guo, Q; Zhou, L J; Wang, X; Wang, Z W

2013-01-01

To seek a better numerical method to simulate the cavitating flow field in a centrifugal pump, the applications between RNG k- ε and LES turbulence model were compared by using the Zwart-Gerber-Belamri cavitation model. It was found that both the models give almost the same results with respect to pump performance and cavitation evolutions including growth, local contraction, stability and separation in the impeller passage. But the LES model can not only capture the pump suction recirculation and the low frequency fluctuation caused by it, but also combine the changes of the shaft frequency amplitude acting on the impeller with the cavitation unstable characteristics. Thus the LES model has more advantages than RNG k- ε model in calculating the unsteady cavitating flow in a centrifugal pump

Numerical investigations on cavitating flows with thermodynamic effects in a diffuser-type centrifugal pump

International Nuclear Information System (INIS)

Xuelin, Tang Xue; Liyuan, Bian; Fujun, Wang; Xiaoqin, Lin; Man, Hao

2013-01-01

A cavitation model with thermodynamic effects for cavitating flows in a diffuser-type centrifugal pump is developed based on the bubble two-phase flow model. The proposed cavitation model includes mass, momentum, and energy transportations according to the thermodynamic mechanism of cavitation. Numerical simulations are conducted inside the entire passage of the centrifugal pump by using the proposed cavitation model and the renormalization group-based k - ε turbulent model coupled with the energy transportation equation. By using the commercial computational fluid dynamics software FLUENT 6.3, we have shown that the predicted performance characteristics of the pump, as well as the pressure, vapor, and density distributions in the impeller, agree well with that calculated by the full cavitation model. Simulation results show that cavitation initially occurs slightly behind the inlet of the blade suction surface, i.e., the area with maximum vapor concentration and minimum pressure. The predicted temperature field shows that the reduction in temperature restrains the growth of cavitating bubbles. Therefore, the thermodynamic effect should be treated as a necessary factor in cavitation models. Comparison results validate the efficiency and accuracy of the numerical technique in simulating cavitation flows in centrifugal pumps.

Research on the effect of wear-ring clearances to the axial and radial force of a centrifugal pump

International Nuclear Information System (INIS)

Zhao, W G; Qi, C X; Li, Y B; He, M Y

2013-01-01

Varying of the wear-ring clearance not only has a distinct effect on the volumetric loss of the centrifugal pump, but also on the performance of the centrifugal pump including the axial and radial forces. Comparing with the experimental studies, numerical simulation methods have some special advantages, such as the low cost, fast and high efficiency, and convenient to get the detailed structure of the internal flow characteristics, so it has been widely used in the fluid machinery study in recent years. In order to study the effect of wear-ring clearance on the force performance of the centrifugal pump, based on the Reynolds Time-Averaged N-S equations and RNG k-ε turbulence model, a centrifugal pump with three variable styles of the wear-rings was simulated: Only the clearance of the front wear-ring was changed, only the clearance of the back wear-ring was changed and both were changed. Comparing with the experiment, numerical results show a good agreement. In the three changing styles of the clearance, the variable of the clearance of front wear-ring has the most influence on the axial force of the centrifugal pump, while has tiny effect on the radial force for all the conditions

Dictionary of centrifugal pumps. 3. rev. ed. Kreiselpumpen Lexikon

Energy Technology Data Exchange (ETDEWEB)

Holzenberger, K; Jung, K [comps.

1989-01-01

This technical dictionary was brought up to date of the state of the art. The terminology was supplemented with terms referring to centrifugal pumps. There are now almost 700 terms, with their English and French translations. To facilitate usage all the terms of books are listed in alphabetical order at the end of the book. (RHM).

Performance of a centrifugal pump running in inverse mode

Energy Technology Data Exchange (ETDEWEB)

Fernandez, J. [Universidad de Extramadura, Badajoz (Spain). Departamento de Electronica e Ingenieria Electromecanica; Blanco, E.; Parrondo, J. [Oviedo Univ. (Spain). Departamento de Energia; Stickland, M.; Scanlon, T.J. [Strathclyde Univ., Glasgow (United Kingdom). Dept. of Mechanical Engineering

2004-08-01

This paper presents the functional characterization of a centrifugal pump used as a turbine. It shows the characteristics of the machine involved at several rotational speeds, comparing the respective flows and heads. In this way, it is possible to observe the influence of the rotational speed on efficiency, as well as obtaining the characteristics at constant head and runaway speed. Also, the forces actuating on the impeller were studied. An uncertainty analysis was made to assess the accuracy of the results. The research results indicate that the turbine characteristics can be predicted to some extent from the pump characteristics, that water flows out of the runner free of swirl flow at the best efficiency point, and that radial stresses are lower than in pump mode. (author)

The creation and research of the disk-type molecular pump above the top end of centrifuge

International Nuclear Information System (INIS)

Li Yunan; Dong Jinping

2014-01-01

Disk-type molecular pump placed above the top end of a centrifuge could improve the vacuum of the sleeve, as well as reduce the friction power consumption. This issue carries out a numerical simulation based on the model of molecular pump installed above the top end of centrifuge. The mathematical model is established and calculated by the Matlab program, studying the gas passageways of pump. The suction performance under the influence of gas passageways' geometric dimensions is analyzed, focusing on the effect of different shapes of side walls in the passageway. Design criterion of increasing the compression ratio of disk-type molecular pump is concluded from the analysis. (authors)

Flow in a Low Specific Speed Centrifugal Pump Using PIV

Directory of Open Access Journals (Sweden)

Cui Dai

2013-01-01

Full Text Available The interflow plays important roles in centrifugal pump design. In order to study the effect of rotation and z-axis on internal flow, two-dimensional particle image velocimetry (PIV measurements have been performed to measure the steady velocity field on three planes in all impeller passages of a low specific-speed centrifugal pump. The results show that the relative velocity flows in blade passages are obviously different in terms of the positions of the blade relative to the tongue. The interaction between the impeller and tongue changes the occurrence and development of low velocity region with time. From shroud to hub, the relative velocity gradually increases, and the minimum value moves toward the suction surface. On the midplane, the magnitude increases with increased flow rate from pressure surface to suction surface, while at the shroud and hub, the measured velocity first increases with decreased flow rate from the blade pressure surface to nearly ζ = 0.5 to 0.6.

Numerical analysis of the flow field in the pump chamber of a centrifugal pump with back blades

International Nuclear Information System (INIS)

Cao, L; Wang, Z W; Luo, Y Y; Liu, M

2013-01-01

Black blade is frequently used as a non-contact seal structure in centrifugal pumps transporting solid-liquid two-phase flow. However, it will disturb the flow in the pump and affect the pump performance. Numerical simulation for 3D turbulence in whole flow passage of a centrifugal pump with back blades was carried out based on RANS method, with SST k-ω turbulence model and SIMPLEC algorithm. Calculation for a similar pump without back blades was also carried out as a comparison. Boundary condition was improved due to the existence of back blade. The influence of back blades on the flow field was analysed qualitatively for three typical conditions. Meanwhile the leakage rate was calculated for several conditions and the effect of back blades was discussed. According to the results, compared with the condition without back blades, it could be seen that back blade apparently changed the flow state in the front chamber, improved near the front shroud and worsened near the pump cover. Velocity was increased and more fluid, which flowed into the front chamber from the pump cover side, flowed back to the spiral casing from the impeller shroud side. With the increase of discharge, the absolute value of leakage rate first went up and then dropped, as a consequence of the combination of two factors, discharge and differential pressure between the impeller outlet and inlet. The seal effect of back blades is most obvious under small discharge condition, and the leakage loss diminished as discharge increased

Gyro-effect stabilizes unstable permanent maglev centrifugal pump.

Science.gov (United States)

Qian, Kun-Xi

2007-03-01

According to Earnshaw's Theorem (1839), the passive maglev cannot achieve stable equilibrium and thus an extra coil is needed to make the rotor electrically levitated in a heart pump. The author had developed a permanent maglev centrifugal pump utilizing only passive magnetic bearings, to keep the advantages but to avoid the disadvantages of the electric maglev pumps. The equilibrium stability was achieved by use of so-called "gyro-effect": a rotating body with certain high speed can maintain its rotation stably. This pump consisted of a rotor (driven magnets and an impeller), and a stator with motor coil and pump housing. Two passive magnetic bearings between rotor and stator were devised to counteract the attractive force between the motor coil iron core and the rotor driven magnets. Bench testing with saline demonstrated a levitated rotor under preconditions of higher than 3,250 rpm rotation and more than 1 l/min pumping flow. Rotor levitation was demonstrated by 4 Hall sensors on the stator, with evidence of reduced maximal eccentric distance from 0.15 mm to 0.07 mm. The maximal rotor vibration amplitude was 0.06 mm in a gap of 0.15 mm between rotor and stator. It concluded that Gyro-effect can help passive maglev bearings to achieve stabilization of permanent maglev pump; and that high flow rate indicates good hydraulic property of the pump, which helps also the stability of passive maglev pump.

The cool seal system: a practical solution to the shaft seal problem and heat related complications with implantable rotary blood pumps.

Science.gov (United States)

Yamazaki, K; Mori, T; Tomioka, J; Litwak, P; Antaki, J F; Tagusari, O; Koyanagi, H; Griffith, B P; Kormos, R L

1997-01-01

A critical issue facing the development of an implantable, rotary blood pump is the maintenance of an effective seal at the rotating shaft. Mechanical seals are the most versatile type of seal in wide industrial applications. However, in a rotary blood pump, typical seal life is much shorter than required for chronic support. Seal failure is related to adhesion and aggregation of heat denatured blood proteins that diffuse into the lubricating film between seal faces. Among the blood proteins, fibrinogen plays an important role due to its strong propensity for adhesion and low transition temperature (approximately 50 degrees C). Once exposed to temperature exceeding 50 degrees C, fibrinogen molecules fuse together by multi-attachment between heat denatured D-domains. This quasi-polymerized fibrin increases the frictional heat, which proliferates the process into seal failure. If the temperature of the seal faces is maintained well below 50 degrees C, a mechanical seal would not fail in blood. Based on this "Cool-Seal" concept, we developed a miniature mechanical seal made of highly thermally conductive material (SiC), combined with a recirculating purge system. A large supply of purge fluid is recirculated behind the seal face to augment convective heat transfer to maintain the seal temperature below 40 degrees C. It also cools all heat generating pump parts (motor coil, bearing, seal). The purge consumption has been optimized to virtually nil (seal system has now been incorporated into our intraventricular axial flow blood pump (IVAP) and newly designed centrifugal pump. Ongoing in vivo evaluation of these systems has demonstrated good seal integrity for more than 160 days. The Cool-Seal system can be applied to any type of rotary blood pump (axial, diagonal, centrifugal, etc.) and offers a practical solution to the shaft seal problem and heat related complications, which currently limit the use of implantable rotary blood pumps.

Numerical identification of blade exit angle effect on the performance for a multistage centrifugal pump impeller

Directory of Open Access Journals (Sweden)

Babayigit Osman

2015-01-01

Full Text Available Nowadays, single and multistage centrifugal pumps are widely used in industrial and mining enterprises. One of the most important components of a centrifugal pump is the impeller. The performance characteristics are related to the pump comprising the head and the overall efficiency rely a great deal on the impeller geometry. In this work, effects of blade exit angle change on hydraulic efficiency of a multi stage pump impeller are investigated via Ansys-Fluent computational fluid dynamics software for constant width impeller entrance and exit gates, blade numbers and blade thickness. Firstly, the flow volume of a centrifugal pump impeller is generated and then mesh structure is formed for the full impeller flow volume. Secondly, rotational periodic flow model are adopted in order to examine the effect of periodic flow assumption on the performance predictions. Corresponding to the available experimental data, inlet mass flow rate, outlet static pressure and rotation of impeller are taken as 0.02m3s-1, 450 kPa and 2950 rpm, respectively for the water fluid. No slip boundary condition is exposed to all solid of surface in the flow volume. The continuity and Navier-Stokes equations with the k-ε turbulence model and the standard wall functions are used. During the study, numerical analyses are conducted for the blade exit angle values of 18°, 20°, 25°, 30° and 35°. In consequence of the performed analyses, it is determined that hydraulic efficiency of the pump impeller value is changed between 81.0-84.6%. The most convenient blade exit angle that yields 84.6% hydraulic efficiency at is 18°. The obtained results show that the blade exit angle range has an impact on the centrifugal pump performance describing the pump head and the hydraulic efficiency.

Extracorporeal gas exchange with the DeltaStream rotary blood pump in experimental lung injury.

Science.gov (United States)

Dembinski, Rolf; Kopp, Rüdger; Henzler, Dietrich; Hochhausen, Nadine; Oslender, Nicole; Max, Martin; Rossaint, Rolf; Kuhlen, Ralf

2003-06-01

In most severe cases of the acute respiratory distress syndrome, veno-venous extracorporeal membrane oxygenation (ECMO) can be used to facilitate gas exchange. However, the clinical use is limited due to the size and the concomitant risk of severe adverse events of conventionally-used centrifugal blood pumps with high extracorporeal blood volumes. The DeltaStream blood pump is a small-sized rotary blood pump that may reduce extracorporeal blood volume, foreign surfaces, contact activation of the coagulation system, and blood trauma. The aim of the present study was to test the safety and efficacy of the DeltaStream pump for ECMO in animals with normal lung function and experimental acute lung injury (ALI). Therefore, veno-venous ECMO was performed for 6 hours in mechanically ventilated pigs with normal lung function (n=6) and with ALI induced by repeated lung lavage (n=6) with a blood flow of 30% of the cardiac output. Gas flow with a FiO2 of 1.0 was set to equal blood flow. With a mean activated clotting time of 121 +/- 22 s, no circulatory impairment or thrombus formation was revealed during ECMO. Furthermore, free plasma Hb did not increase. In controls, hemodynamics and gas exchange remained unchanged. In animals with ALI, hemodynamics remained stable and gas transfer across the extracorporeal oxygenators was optimal, but only in 2 animals was a marked increase in PaO2 observed. CO2 removal was efficacious in all animals. We concluded that the DeltaStream blood pump may be used for veno-venous ECMO without major blood damage or hemodynamic impairment.

System of Thermal Balance Maintenance in Modern Test Benches for Centrifugal Pumps

Directory of Open Access Journals (Sweden)

A. I. Petrov

2015-01-01

Full Text Available The article “Systems of the heat balance maintenance in modern test benches for centrifugal pumps” makes the case to include cooling systems of a working fluid (heat setting in test bench for impeller pumps. It briefly summarizes an experience of bench building to test centrifugal pumps, developed at the BMSTU Department E-10 over the last 10 years. The article gives the formulas and the algorithm to calculate the heat capacity of different types of impeller pumps when tested at the bench as ell as to determine the heating time of the liquid in the bench without external cooling. Based on analysis of the power balance of a centrifugal pump, it is shown that about 90% of the pump unit-consumed electric power in terminals is used for heating up the working fluid in the loop of the test bench. The article gives examples of elementary heat calculation of the pump operation within the test bench. It presents the main types of systems to maintain thermal balance, their advantages, disadvantages and possible applications. The cooling system schemes for open and closed version of the benches both with built-in and with an independent cooling circuit are analysed. The paper separately considers options of such systems for large benches using the cooling tower as a cooling device in the loop, and to test the pumps using the hydraulic fluids other than water, including those at high temperatures of working fluids; in the latter case a diagram of dual-circuit cooling system "liquid-liquid-air" is shown. The paper depicts a necessity to use ethylene glycol coolant in the two-loop cooling bench. It provides an example of combining the functions of cooling and filtration in a single cooling circuit. Criteria for effectiveness of these systems are stated. Possible ways for developing systems to maintain a thermal balance, modern methods of regulation and control are described. In particular, the paper shows the efficiency of frequency control of the

Transient internal characteristic study of a centrifugal pump during startup process

International Nuclear Information System (INIS)

Hu, F F; Ma, X D; Wu, D Z; Wang, L Q

2012-01-01

The transient process of a centrifugal pump existed in a variety of occasions. There were a lot of researches in the external characteristic in startup process and stopping process, but internal characteristics were less observed and studied. Study of the internal flow field had significant meanings. The performance of a pump could be evaluated and improved by revealing the flow field. In the other hand, the prediction of external characteristic was based on the correct analysis of the internal flow. In this paper, theoretical method and numerical simulation were used to study the internal characteristic of a centrifugal pump. The theoretical study showed that the relative flow in an impeller was composed of homogeneous flow and axial vortex flow. The vortex intensity was mainly determined by angular velocity of impeller, flow channel width and blade curvature. In order to get the internal flow field and observe the evolution of transient internal flow in the impeller, Computational Fluid Dynamics(CFD) were used to study the three-dimensional unsteady incompressible viscous flows in a centrifugal pump during starting period. The Dynamic Mesh (DM) method with non-conformal grid boundaries was applied to get the external characteristic and internal flow field. The simulate model included three pumps with different blade numbers and the same blade curvature. The relative velocity vector showed that there was a big axial vortex in impeller channel. At the beginning, the vortex was raised in the pressure side of the impeller outlet and with time went on, it shifted to the middle flow channel of the impeller and the vortex intensity increased. When the speed and flow rate reached a definite value, the influence of the axial vortex began to get smaller. The vortex developed faster when the flow channel got narrower. Due to the evolution of axial vortex, the slip factor during starting period was smaller than that in quasi-steady condition. As a result, transient head was

Defect diagnosis and root cause analysis for thrust roller bearing of centrifugal charging pump

International Nuclear Information System (INIS)

Guo Yi

2012-01-01

The centrifugal charging pump is one of the most important equipment for Nuclear power plant which requires very high reliability, during C9 fuel-cycle, the continuous high level vibration alarm happened on the centrifugal charging pump B, we diagnosed its faults correctly and selected the right operation mode and right time to dismantle it which ensure the safety and economic benefits of Nuclear power plant, and through deeply analysis the root causes of thrust bearing defaults, we can learn much from it especially for the diagnosis and analysis to the bearing faults which is common for rotating equipment. (author)

Unsteady numerical simulation for gas–liquid two-phase flow in self-priming process of centrifugal pump

International Nuclear Information System (INIS)

Huang, Si; Su, Xianghui; Guo, Jing; Yue, Le

2014-01-01

Highlights: • The transient gas–liquid two-phase flow fields in the self-priming centrifugal pump are simulated. • The self-priming time and performance are estimated. • The air void fraction and two phase distribution are obtained.· The hole on the volute plays a significant role for gas exhausting. • The frequency of the impulsive pressure basically conforms to that of the air exhausted out of the pump. - Abstract: Self-priming pumps start up without pre-irrigation, and then work as common pumps when air in the pump is exhausted. The transient gas–liquid flow at the start-up stage inside a self-priming pump is an interesting process which greatly influences performance of the pump. In this paper, a conventional vertical self-priming centrifugal pump was selected as the object. Using unsteady numerical simulation, the authors investigated the transient gas–liquid two-phase flow in the self-priming centrifugal pump during the self-priming process. The main innovation in the simulation was that a section of the suction pipe filled with air was set as the initial condition, which conformed to the actual self-priming conditions. The gas–liquid two-phase distribution, the pressure and velocity in relation to time were computed and analyzed. Flow rates of both phases with time at the pump inlet and outlet were obtained based on the simulation, which could be used to estimate the self-priming time and other performance parameters. Finally, the numerical method and results for gas–liquid two-phase flow in the self-priming pump was partly validated by the pump performance test

Improved Outcome of Cardiac Extracorporeal Membrane Oxygenation in Infants and Children Using Magnetic Levitation Centrifugal Pumps.

Science.gov (United States)

Luciani, Giovanni Battista; Hoxha, Stiljan; Torre, Salvatore; Rungatscher, Alessio; Menon, Tiziano; Barozzi, Luca; Faggian, Giuseppe

2016-01-01

Extracorporeal membrane oxygenation (ECMO) has traditionally been and, for the most part, still is being performed using roller pumps. Use of first-generation centrifugal pumps has yielded controversial outcomes, perhaps due to mechanical properties of the same and the ensuing risk of hemolysis and renal morbidity. Latest-generation centrifugal pumps, using magnetic levitation (ML), exhibit mechanical properties which may have overcome limitations of first-generation devices. This retrospective study aimed to assess the safety and efficacy of veno-arterial (V-A) ECMO for cardiac indications in neonates, infants, and children, using standard (SP) and latest-generation ML centrifugal pumps. Between 2002 and 2014, 33 consecutive neonates, infants, and young children were supported using V-A ECMO for cardiac indications. There were 21 males and 12 females, with median age of 29 days (4 days-5 years) and a median body weight of 3.2 kg (1.9-18 kg). Indication for V-A ECMO were acute circulatory collapse in ICU or ward after cardiac repair in 16 (49%) patients, failure to wean after repair of complex congenital heart disease in 9 (27%), fulminant myocarditis in 4 (12%), preoperative sepsis in 2 (6%), and refractory tachy-arrhythmias in 2 (6%). Central cannulation was used in 27 (81%) patients and peripheral in 6. Seven (21%) patients were supported with SP and 26 (79%) with ML centrifugal pumps. Median duration of support was 82 h (range 24-672 h), with 26 (79%) patients weaned from support. Three patients required a second ECMO run but died on support. Seventeen (51%) patients required peritoneal dialysis for acute renal failure. Overall survival to discharge was 39% (13/33 patients). All patients with fulminant myocarditis and with refractory arrhythmias were weaned, and five (83%) survived, whereas no patient supported for sepsis survived. Risk factors for hospital mortality included lower (pumps in infants and children yields outcomes absolutely comparable to

Parametric representation of centrifugal pump homologous curves

International Nuclear Information System (INIS)

Veloso, Marcelo A.; Mattos, Joao R.L. de

2015-01-01

Essential for any mathematical model designed to simulate flow transient events caused by pump operations is the pump performance data. The performance of a centrifugal pump is characterized by four basic quantities: the rotational speed, the volumetric flow rate, the dynamic head, and the hydraulic torque. The curves showing the relationships between these four variables are called the pump characteristic curves. The characteristic curves are empirically developed by the pump manufacturer and uniquely describe head and torque as functions of volumetric flow rate and rotation speed. Because of comprising a large amount of points, this configuration is not suitable for computational purposes. However, it can be converted to a simpler form by the development of the homologous curves, in which dynamic head and hydraulic torque ratios are expressed as functions of volumetric flow and rotation speed ratios. The numerical use of the complete set of homologous curves requires specification of sixteen partial curves, being eight for the dynamic head and eight for the hydraulic torque. As a consequence, the handling of homologous curves is still somewhat complicated. In solving flow transient problems that require the pump characteristic data for all the operation zones, the parametric form appears as the simplest way to deal with the homologous curves. In this approach, the complete characteristics of a pump can be described by only two closed curves, one for the dynamic head and other for the hydraulic torque, both in function of a single angular coordinate defined adequately in terms of the quotient between volumetric flow ratio and rotation speed ratio. The usefulness and advantages of this alternative method are demonstrated through a practical example in which the homologous curves for a pump of the type used in the main coolant loops of a pressurized water reactor (PWR) are transformed to the parametric form. (author)

Paste pumping and deposition field trials and concepts on Syncrude's dewatered mature fine tailings MFT centrifuge cake

Energy Technology Data Exchange (ETDEWEB)

Lahaie, R. [Syncrude Canada Ltd., Edmonton, AB (Canada); Ahmed, I.; Labelle, M.; Brown, R. [Golder Paste Technology, Sudbury, ON (Canada)

2009-07-01

This presentation discussed a paste pumping and deposition field study conducted on dewatered mature fine tailings (MFT) located at Syncrude's Mildred Lake operation. Bench scale rheological examinations of centrifuge cakes and design field testing are used to determine the pumpability of MFT centrifuge cakes. The study included a transportation assessment for the conveyor and positive displacement pumps and pipelines, as well as geotechnical and environmental analyses of bulk materials. Flocculant optimization and centrifuge operational parameter assessments were conducted. Pressure differential and flow rate data were captured in the field studies in order to determine pipeline friction loss. The study showed that pipe friction factors can be obtained using the Bingham plastic model. A natural deposition angle was determined for the MFT centrifuged cake. The study showed that the cake must be sheared in order to reduce yield stress before pumping. It was concluded that displacement pumps can be used to reduced pipeline friction factors. tabs., figs.

Study on cavitation in centrifugal sodium pumps for FBTR and PFBR

International Nuclear Information System (INIS)

Rao, A.S.L.K.; Prabhakar, R.; Prakash, V.; Paranjpe, S.R.

2002-01-01

Fast Breeder Test Reactor (FBTR) which is expected to become critical shortly is a loop type reactor of 40 MW thermal capacity and has two primary and two secondary centrifugal pumps for heat removal. During the initial periods of reactor operation, the steam generator is bypassed and the secondary sodium pumps are required to operate at flows less than that at best efficiency point. This paper deals with the cavitation problems associated with operation at partial f lows, theoretical estimations and experimental cavitation measurements carried out on FBTR secondary sodium pumps. These investigations revealed that operation of FBTR pumps at this off design condition is free from cavitation damage. Cavitation experiments on a model pump for the development of large sodium pumps for a 500 MWe Prototype Fast Breeder Reactor (PFBR) are described in this paper

Prediction of centrifugal pump-cleaning ability in waste sludge

International Nuclear Information System (INIS)

Churnetski, B.V.

1981-01-01

Radioactive waste at the Savannah River Plant (SRP) is being transferred from older waste tanks to new, stress-relieved tanks for more effective waste management. The technology developed for waste removal involves the use of long-shaft, recirculating, centrifugal pumps (slurry pumps). Testing completed at the Savannah River Laboratory's 30-meter-diameter mock-up waste tank related the effective cleaning radius (ECR) of a slurry pump to critical pump and materials characteristics. Presently, this theory is being applied to radioactive waste at SRP. However, the technology can be applied to other remote handling situations where the slurry rheology can be determined. For SRP waste, an equation of the form: ECR α DV 0 (rho/tau 0 )/sup 1/2/ was determined where D is the nozzle diameter, V 0 is the average initial velocity, rho is the density of the slurry, and tau 0 is the yield stress of the slurry. Using this relationship, the cleaning performance of a pump operating in any SRP sludge environment can be predicted. Specifically, yield stress and density measurements on sludge samples can be used to predict the required number and effective location for slurry pumps in actual SRP waste tanks

Research on the induction motor current signature for centrifugal pump at cavitation condition

Directory of Open Access Journals (Sweden)

Yin Luo

2015-11-01

Full Text Available Cavitation is a major undesirable phenomenon for centrifugal pump because it can cause hydraulic performance deterioration, pump damage by pitting and material erosion, and structural vibration and noise. Cavitation can appear within the entire range of the operating conditions; therefore, it must be prevented by all means. Sensorless monitoring technology based on motor current signature analysis is non-intrusive and economic for monitoring motor-driven equipment. Thus, this technology is suitable for centrifugal pump systems. The motor current signature for centrifugal pump load at the cavitation condition is the basis of this technology. However, systematic research is lacking on sensorless monitoring technology based on motor current signature. As a result, the tentative exploration for motor current signature at cavitation load was conducted in this study. The results show that the stator current is still a sinusoidal alternating current strictly to the law of sine. Moreover, the root mean square of the current fluctuates because of different flow regimes in the cavitation progress and decreases because vapor density is smaller than water density when cavitation is fully formed. For the stator current spectrum, the noise level, noise distribution, rotation speed, and vane pass frequency components show features in the cavitation process. These indicator indexes change according to the stage of cavitation development. Thus, the motor current signature analysis is found to be a feasible and cost-effective method for the stages of cavitation condition.

Development of the Floating Centrifugal Pump by Use of Non Contact Magnetic Drive and Its Performance

Directory of Open Access Journals (Sweden)

Mitsuo Uno

2004-01-01

Full Text Available This article focuses on the impeller construction, non contact driving method and performance of a newly developed shaftless floating pump with centrifugal impeller. The drive principle of the floating impeller pump used the magnet induction method similar to the levitation theory of the linear motor. In order to reduce the axial thrust by the pressure different between shroud and disk side, the balance hole and the aileron blade were installed in the floating impeller. Considering the above effect, floating of an impeller in a pump was realized. Moreover, the performance curves of a developed pump are in agreement with a general centrifugal pump, and the dimensionless characteristic curve also agrees under the different rotational speed due to no mechanical friction of the rotational part. Therefore, utility of a non contacting magnetic-drive style pump with the floating impeller was made clear.

Numerical research on the effects of impeller pump-out vanes on axial force in a solid-liquid screw centrifugal pump

International Nuclear Information System (INIS)

Cheng, X R; Li, R N; Gao, Y; Guo, W L

2013-01-01

A commercial CFD code has been used to predict the performance of a screw centrifugal pump with pump-out vanes, especially when changing regularity of impeller axial force based on the solid-liquid two-phase flow. The Unsteady Reynolds Averaged Navier-Stokes (URANS) approach has been applied to solve the unsteady, incompressible, three-dimensional turbulent. The SIMPLEC algorithm, standard wall functions and mix two-phase flow model were applied. The RNG k ε-model was used to account the turbulence effects. By changing the number of impeller pump-out vanes and width, six different screw centrifugal pump numerical simulation projects were given, and each scheme in the different solid volume fraction were calculated respectively. The change rules of axial force, velocity and pressure distribution of flow field were obtained on the different condition and different volume fraction. The results showed that the axial forces values based solid-fluid two-phase greater than based single-phase clear water, but both changing regularity of the axial force were consistent; as same condition, the same solid-phase volume concentration, with the increase of pump-out vanes number or width, the impeller axial force increased as well. Meanwhile the number of the pump-out vanes and the width of pump-out vanes in balancing the impeller axial force, there are the most optimal value

Feasibility of the optical imaging of thrombus formation in a rotary blood pump by near-infrared light.

Science.gov (United States)

Sakota, Daisuke; Murashige, Tomotaka; Kosaka, Ryo; Nishida, Masahiro; Maruyama, Osamu

2014-09-01

Blood coagulation is one of the primary concerns when using mechanical circulatory support devices such as blood pumps. Noninvasive detection and imaging of thrombus formation is useful not only for the development of more hemocompatible devices but also for the management of blood coagulation to avoid risk of infarction. The objective of this study is to investigate the use of near-infrared light for imaging of thrombus formation in a rotary blood pump. The optical properties of a thrombus at wavelengths ranging from 600 to 750 nm were analyzed using a hyperspectral imaging (HSI) system. A specially designed hydrodynamically levitated centrifugal blood pump with a visible bottom area was used. In vitro antithrombogenic testing was conducted five times with the pump using bovine whole blood in which the activated blood clotting time was adjusted to 200 s prior to the experiment. Two halogen lights were used for the light sources. The forward scattering through the pump and backward scattering on the pump bottom area were imaged using the HSI system. HSI showed an increase in forward scattering at wavelengths ranging from 670 to 750 nm in the location of thrombus formation. The time at which the thrombus began to form in the impeller rotating at 2780 rpm could be detected. The spectral difference between the whole blood and the thrombus was utilized to image thrombus formation. The results indicate the feasibility of dynamically detecting and imaging thrombus formation in a rotary blood pump. Copyright © 2014 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

Polar representation of centrifugal pump homologous curves

International Nuclear Information System (INIS)

Veloso, Marcelo Antonio; Mattos, Joao Roberto Loureiro de

2008-01-01

Essential for any mathematical model designed to simulate flow transient events caused by pump operations is the pump performance data. The performance of a centrifugal pump is characterized by four basic parameters: the rotational speed, the volumetric flow rate, the dynamic head, and the hydraulic torque. Any one of these quantities can be expressed as a function of any two others. The curves showing the relationships between these four variables are called the pump characteristic curves, also referred to as four-quadrant curves. The characteristic curves are empirically developed by the pump manufacturer and uniquely describe head and torque as functions of volumetric flow rate and rotation speed. Because of comprising a large amount of points, the four-quadrant configuration is not suitable for computational purposes. However, it can be converted to a simpler form by the development of the homologous curves, in which dynamic head and hydraulic torque ratios are expressed as functions of volumetric flow and rotation speed ratios. The numerical use of the complete set of homologous curves requires specification of sixteen partial curves, being eight for the dynamic head and eight for the hydraulic torque. As a consequence, the handling of homologous curves is still somewhat complicated. In solving flow transient problems that require the pump characteristic data for all the operation zones, the polar form appears as the simplest way to represent the homologous curves. In the polar method, the complete characteristics of a pump can be described by only two closed curves, one for the dynamic head and other for the hydraulic torque, both in function of a single angular coordinate defined adequately in terms of the quotient between volumetric flow ratio and rotation speed ratio. The usefulness and advantages of this alternative method are demonstrated through a practical example in which the homologous curves for a pump of the type used in the main coolant loops of a

BIOMATERIALS FOR ROTARY BLOOD PUMPS

NARCIS (Netherlands)

VANOEVEREN, W

Rotary blood pumps are used for cardiac assist and cardiopulmonary support since mechanical blood damage is less than with conventional roller pumps. The high shear rate in the rotary pump and the reduced anticoagulation of the patient during prolonged pumping enforces high demands on the

Numerical Investigation of Pressure Fluctuation Characteristics in a Centrifugal Pump with Variable Axial Clearance

Directory of Open Access Journals (Sweden)

Lei Cao

2016-01-01

Full Text Available Clearance flows in the sidewall gaps of centrifugal pumps are unsteady as well as main flows in the volute casing and impeller, which may cause vibration and noise, and the corresponding pressure fluctuations are related to the axial clearance size. In this paper, unsteady numerical simulations were conducted to predict the unsteady flows within the entire flow passage of a centrifugal pump operating in the design condition. Pressure fluctuation characteristics in the volute casing, impeller, and sidewall gaps were investigated with three axial clearance sizes. Results show that an axial clearance variation affects the pressure fluctuation characteristics in each flow domain by different degree. The greatest pressure fluctuation occurs at the blade pressure surface and is almost not influenced by the axial clearance variation which has a certainly effect on the pressure fluctuation characteristics around the tongue. The maximum pressure fluctuation amplitude in the sidewall gaps is larger than that in the volute casing, and different spectrum characteristics show up in the three models due to the interaction between the clearance flow and the main flow as well as the rotor-stator interaction. Therefore, clearance flow should be taken into consideration in the hydraulic design of centrifugal pumps.

Numerical simulation of dynamic flow characteristics in a centrifugal water pump with three-vaned diffuser

Directory of Open Access Journals (Sweden)

Zhi-Jun Shuai

2015-08-01

Full Text Available The complex three-dimensional turbulent flow field in a centrifugal water pump with three asymmetrical diffusers was numerically simulated. The characteristics of pressure and force fluctuations inside the model pump were investigated. Fast Fourier transformation was performed to obtain the spectra of pressure and force fluctuations. It indicates that the dominant frequency of pressure fluctuations is the blade passing frequency in all the sub-domains inside the pump and the first blade passing frequency energy (first order of blade passing frequency is the most significant. The dominant frequency of pressure fluctuations at the location of diffuser outlet is featured by low frequency (less than 1 Hz, which may be due to the locally generated eddy structures. Besides, the dominant frequency force fluctuations on the impeller blades are also the blade passing frequency. The existence of the three asymmetrical diffusers has damping effect on the pressure fluctuation amplitude and energy amplitude of pressure fluctuations in the diffuser domain dramatically, which indicates that the diffusers can effectively control the hydraulically excited vibration in the pump. Besides, the prediction of the dominant frequency of pressure fluctuations inside the pump can help to utilize the pump effectively and to extend the pump life. The main findings of this work can provide prediction of the pump performance and information for further optimal design of centrifugal pumps as well.

2011 IEEE Visualization Contest Winner: Visualizing Unsteady Vortical Behavior of a Centrifugal Pump

KAUST Repository

Otto, Mathias; Kuhn, Alexander; Engelke, Wito; Theisel, Holger

2012-01-01

In the 2011 IEEE Visualization Contest, the dataset represented a high-resolution simulation of a centrifugal pump operating below optimal speed. The goal was to find suitable visualization techniques to identify regions of rotating stall

21 CFR 864.9275 - Blood bank centrifuge for in vitro diagnostic use.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Blood bank centrifuge for in vitro diagnostic use. 864.9275 Section 864.9275 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Manufacture Blood and Blood Products § 864.9275 Blood bank centrifuge for in vitro diagnostic use. (a...

Numerical investigation of solid-liquid two phase flow in a non-clogging centrifugal pump at off-design conditions

International Nuclear Information System (INIS)

Zhao, B J; Chen, H L; Hou, D H; Huang, Z F

2012-01-01

The solid-liquid two-phase flow fields in the non-clogging centrifugal pump with a double-channel impeller have been investigated numerically for the design condition and also off-design conditions, in order to study the solid-liquid two-phase flow pattern and non-clogging mechanism in non-clogging centrifugal pumps. The main conclusions include: The sand volume fraction distribution is extremely inhomogeneous in the whole flow channel of the pump at off-design conditions. In the impeller, particles mainly flow along the pressure surface and hub; In the volute, particles mainly accumulate in the region near to the exit of volute, the largest sand volume fraction is observed at the tongue, and a large number of particles collide with volute wall and exit the volute after circling around the volute for several times. When the particle diameter increases, particles tend to accumulate on the pressure side of the impeller, and more particles crash with the pressure side of the blade. And larger sand volume fraction gratitude is also observed in the whole flow channel of the pump. With the decrease of the inlet sand volume fraction, particles tend to accumulate on the suction side of the blade. Compared with the particle diameter, the inlet sand volume fraction has less influence on the sand volume fraction gratitude in the whole channel of the pump. At the large flow rate, the minimum and maximum sand volume fraction in the whole flow channel of the model pump tends to be smaller than that at the small flow rate. Thus, it is concluded that the water transportation capacity increases with the flow rate. This research will strengthen people's understanding of the multiphase flow pattern in non-clogging centrifugal pumps, thus provides a theoretical basis for the optimal design of non-clogging centrifugal pumps.

Model based fault diagnosis in a centrifugal pump application using structural analysis

DEFF Research Database (Denmark)

Kallesøe, C. S.; Izadi-Zamanabadi, Roozbeh; Rasmussen, Henrik

2004-01-01

A model based approach for fault detection and isolation in a centrifugal pump is proposed in this paper. The fault detection algorithm is derived using a combination of structural analysis, Analytical Redundant Relations (ARR) and observer designs. Structural considerations on the system are used...

Model Based Fault Diagnosis in a Centrifugal Pump Application using Structural Analysis

DEFF Research Database (Denmark)

Kallesøe, C. S.; Izadi-Zamanabadi, Roozbeh; Rasmussen, Henrik

2004-01-01

A model based approach for fault detection and isolation in a centrifugal pump is proposed in this paper. The fault detection algorithm is derived using a combination of structural analysis, Analytical Redundant Relations (ARR) and observer designs. Structural considerations on the system are used...

Studies of the impact of prerotation problem of the secondary impeller on performance of multi-stage centrifugal pumps

International Nuclear Information System (INIS)

Zhai, L L; Wu, P; Jiang, Q L; Wang, L Q

2012-01-01

In engineering practice, part of the multi-stage centrifugal pumps is designed without space guide vanes due to the size restrictions and the volute is distorted much in shape. In these pumps, tangential velocity of the fluid at the outlet of the first-stage impeller is so great that it has caused a prerotation problem which will affect the inlet flow conditions of the secondary impeller leading to serious efficiency and head decline of the secondary impeller. The head problem of the second stage in multi-stage centrifugal pumps caused by prerotation at the entrance of the second stage was analyzed and the internal hydraulic performance was optimized by setting clapboards in the volute in this paper. CFD numerical simulation method combined with experiment was applied to predict the effect of internal clapboards on the performance of the centrifugal pump. The original prototype was transformed according to the simulation result and tested to verify the optimization work. The experiment result shows that hydraulic performance is remarkably improved compared with the original one and the prerotation problem is basically solved.

Effect of Bearing Housings on Centrifugal Pump Rotor Dynamics

Science.gov (United States)

Yashchenko, A. S.; Rudenko, A. A.; Simonovskiy, V. I.; Kozlov, O. M.

2017-08-01

The article deals with the effect of a bearing housing on rotor dynamics of a barrel casing centrifugal boiler feed pump rotor. The calculation of the rotor model including the bearing housing has been performed by the method of initial parameters. The calculation of a rotor solid model including the bearing housing has been performed by the finite element method. Results of both calculations highlight the need to add bearing housings into dynamic analyses of the pump rotor. The calculation performed by modern software packages is more a time-taking process, at the same time it is a preferred one due to a graphic editor that is employed for creating a numerical model. When it is necessary to view many variants of design parameters, programs for beam modeling should be used.

An analytical investigation on the valve and centrifugal pump speed control with a constant differential pressure across the valve

International Nuclear Information System (INIS)

Jung, B. R.; Joo, K. I.; Lee, B. J.; Baek, S. J.; Noh, T. S.

2003-01-01

A valve opening and centrifugal pump speed control was investigated analytically in a simple pumping system where the differential pressure across the control valve is maintained constant over the required flow range. The valve control program was derived analytically only as a function of the required flow rate to maintain the constant differential pressure across the valve. The centrifugal pump speed control program was also derived analytically for the required flow rate for the constant differential pressure across the control valve. These derivations theoretically show that the independent control is possible between the valve and pump speed in a system with a constant valve pressure drop. In addition, it was shown that a linear pump speed control is impossible in maintaining the constant valve pressure drop

Development of a miniaturized mass-flow meter for an axial flow blood pump based on computational analysis.

Science.gov (United States)

Kosaka, Ryo; Nishida, Masahiro; Maruyama, Osamu; Yamane, Takashi

2011-09-01

In order to monitor the condition of patients with implantable left ventricular assist systems (LVAS), it is important to measure pump flow rate continuously and noninvasively. However, it is difficult to measure the pump flow rate, especially in an implantable axial flow blood pump, because the power consumption has neither linearity nor uniqueness with regard to the pump flow rate. In this study, a miniaturized mass-flow meter for discharged patients with an implantable axial blood pump was developed on the basis of computational analysis, and was evaluated in in-vitro tests. The mass-flow meter makes use of centrifugal force produced by the mass-flow rate around a curved cannula. An optimized design was investigated by use of computational fluid dynamics (CFD) analysis. On the basis of the computational analysis, a miniaturized mass-flow meter made of titanium alloy was developed. A strain gauge was adopted as a sensor element. The first strain gauge, attached to the curved area, measured both static pressure and centrifugal force. The second strain gauge, attached to the straight area, measured static pressure. By subtracting the output of the second strain gauge from the output of the first strain gauge, the mass-flow rate was determined. In in-vitro tests using a model circulation loop, the mass-flow meter was compared with a conventional flow meter. Measurement error was less than ±0.5 L/min and average time delay was 0.14 s. We confirmed that the miniaturized mass-flow meter could accurately measure the mass-flow rate continuously and noninvasively.

Geometric Optimization for Non-Thrombogenicity of a Centrifugal Blood Pump through Computational Fluid Dynamic Analysis

Science.gov (United States)

Nishida, Masahiro; Yamane, Takashi

A monopivot magnetic suspension blood pump has been developed in our laboratory. The flow patterns within the pump should be carefully examined in order to prevent thrombogenesis, especially around the pivot bearing. Therefore, the effects of the pump geometry on the local flow were analyzed using computational fluid dynamics together with the experimental flow visualization. The engineering goal was to reduce the area of stagnation around the pivot in order to prevent thrombus formation. As a result, the stagnation area and the flow rate through the washout holes were found to be highly affected by the size and geometry of the washout holes. Secondary flow was revealed to form a jet-like wash against the pivot, thus preventing thrombus formation. The flow rate through the washout holes was estimated to be up to one fifth of the pump flow rate, depending on the cross-sectional areas of the washout holes. Furthermore, an anti-thrombogenic effect was attained by removing a small gap between the male and female pivots.

Numerical and Experimental Investigation of Cavitating Characteristics in Centrifugal Pump with Gap Impeller

Science.gov (United States)

Zhu, Bing; Chen, Hongxun; Wei, Qun

2014-06-01

This paper is to study the cavitating characteristics in a low specific speed centrifugal pump with gap structure impeller experimentally and numerically. A scalable DES numerical method is proposed and developed by introducing the von Karman scale instead of the local grid scale, which can switch at the RANS and LES region interface smoothly and reasonably. The SDES method can detect and grasp unsteady scale flow structures, which were proved by the flow around a triangular prism and the cavitation flow in a centrifugal pump. Through numerical and experimental research, it's shown that the simulated results match qualitatively with tested cavitation performances and visualization patterns, and we can conclude that the gap structure impeller has a superior feature of cavitation suppression. Its mechanism may be the guiding flow feature of the small vice blade and the pressure auto-balance effect of the gap tunnel.

Egg beater as centrifuge: isolating human blood plasma from whole blood in resource-poor settings.

Science.gov (United States)

Wong, Amy P; Gupta, Malancha; Shevkoplyas, Sergey S; Whitesides, George M

2008-12-01

This paper demonstrates that a hand-powered egg beater can be modified to serve as a centrifuge for separating plasma from human whole blood. Immunoassays used to diagnose infectious diseases often require plasma from whole blood, and obtaining plasma typically requires electrically-powered centrifuges, which are not widely available in resource-limited settings. Human whole blood was loaded into polyethylene (PE) tubing, and the tubing was attached to the paddle of an egg beater. Spinning the paddle pelleted the blood cells to the distal end of the PE tubing; the plasma remained as the supernatant. A cholesterol assay (run on patterned paper) demonstrated the suitability of this plasma for use in diagnostic assays. The physics of the system was also analyzed as a guide for the selection of other rotating systems for use in centrifugation. Egg beaters, polyethylene tubing, and paper are readily available devices and supplies that can facilitate the use of point-of-care diagnostics at sites far from centralized laboratory facilities.

A Comparative Assessment of Spalart-Shur Rotation/Curvature Correction in RANS Simulations in a Centrifugal Pump Impeller

Directory of Open Access Journals (Sweden)

Ran Tao

2014-01-01

Full Text Available RANS simulation is widely used in the flow prediction of centrifugal pumps. Influenced by impeller rotation and streamline curvature, the eddy viscosity models with turbulence isotropy assumption are not accurate enough. In this study, Spalart-Shur rotation/curvature correction was applied on the SST k-ω turbulence model. The comparative assessment of the correction was proceeded in the simulations of a centrifugal pump impeller. CFD results were compared with existing PIV and LDV data under the design and low flow rate off-design conditions. Results show the improvements of the simulation especially in the situation that turbulence strongly produced due to undesirable flow structures. Under the design condition, more reasonable turbulence kinetic energy contour was captured after correction. Under the low flow rate off-design condition, the prediction of turbulence kinetic energy and velocity distributions became much more accurate when using the corrected model. So, the rotation/curvature correction was proved effective in this study. And, it is also proved acceptable and recommended to use in the engineering simulations of centrifugal pump impellers.

The effect of increased centrifugation temperature on the quality of red-blood-cell concentrates of automated whole blood processing.

Science.gov (United States)

Weinigel, C; Rummler, S; Barz, D

2013-10-01

There are manual and automated methods to separate whole blood (WB) available. The Atreus whole blood processing system is an automated method, which combines centrifugation and expression of components into a single device. A major difference to conventional methods is that centrifugation temperature is not controlled at 22°C. The aim of this study was to examine the influence of increased centrifugation temperatures on the quality of red-blood-cell concentrates (RCC) after active cooling of WB prior to processing. A total of 28 WB were processed: 16 at centrifugation temperatures of up to 28°C (1st protocol) and 12 at 34°C (2nd protocol). RCC quality parameters were tested weekly for 42 days. Red-blood-cell concentrates (RCC) quality complied with the European and German guidelines. Haemolysis was not significantly different throughout storage. Significant statistical differences were detected between both protocols in potassium concentration at the end of storage and in ATP levels at the day of processing. Centrifugation temperatures of up to 34°C are well tolerated by the red blood cells with minimal interference with the RCC quality parameters. © 2013 International Society of Blood Transfusion.

Application of computational fluid dynamics and surrogate-coupled evolutionary computing to enhance centrifugal-pump performance

Directory of Open Access Journals (Sweden)

Sayed Ahmed Imran Bellary

2016-01-01

Full Text Available To reduce the total design and optimization time, numerical analysis with surrogate-based approaches is being used in turbomachinery optimization. In this work, multiple surrogates are coupled with an evolutionary genetic algorithm to find the Pareto optimal fronts (PoFs of two centrifugal pumps with different specifications in order to enhance their performance. The two pumps were used a centrifugal pump commonly used in industry (Case I and an electrical submersible pump used in the petroleum industry (Case II. The objectives are to enhance head and efficiency of the pumps at specific flow rates. Surrogates such as response surface approximation (RSA, Kriging (KRG, neural networks and weighted-average surrogates (WASs were used to determine the PoFs. To obtain the objective functions’ values and to understand the flow physics, Reynolds-averaged Navier–Stokes equations were solved. It is found that the WAS performs better for both the objectives than any other individual surrogate. The best individual surrogates or the best predicted error sum of squares (PRESS surrogate (BPS obtained from cross-validation (CV error estimations produced better PoFs but was still unable to compete with the WAS. The high CV error-producing surrogate produced the worst PoFs. The performance improvement in this study is due to the change in flow pattern in the passage of the impeller of the pumps.

Application of heterogeneous blading systems is the way for improving efficiency of centrifugal energy pumps

Science.gov (United States)

Pochylý, F.; Haluza, M.; Fialová, S.; Dobšáková, L.; Volkov, A. V.; Parygin, A. G.; Naumov, A. V.; Vikhlyantsev, A. A.; Druzhinin, A. A.

2017-11-01

The results of independent research implemented by the teams of authors representing the Brno University of technology (Czech Republic) and Moscow Power Engineering Institute National Research University (Russia) are presented and compared. The possibilities for improving the energy efficiency of slow-speed centrifugal pumps (with a specific speed coefficient n s engineering—in thermal power stations, in heat electric-power stations, in nuclear power plants, and in boiler rooms—were investigated. These are supply pumps, condensate pumps, precharge pumps, etc. The pumps with such values of n s are widely used in some technological cycles of oil-and-gas and chemical industries too. The research was focused on achieving the shape of the pump efficiency characteristics providing a significant extension of its effective working zone and increasing its integrated efficiency. The results were obtained based on new approaches to the formation of a blading system of an impeller of a slow-speed centrifugal pump different from the traditional blading system. The analytical dependences illustrating the influence of individual geometry of a blading system on the efficiency were presented. The possibilities of purposeful changing of its structure were demonstrated. It was experimentally confirmed that use of the innovative blading system makes it possible to increase the pump efficiency by 1-4% (in the experiments for the pumps with n s = 33 and 55) and to extend its efficient working zone approximately by 15-20% (in the experiment for the pumps with n s = 33 and 66). The latter is especially important for the supply pumps of NPP power units. The experimental results for all investigated pumps are presented in comparison with the characteristics of the efficiency provided by the blading systems designed by traditional methods.

Impellers of low specific speed centrifugal pump based on the draughting technology

International Nuclear Information System (INIS)

Hongxun, C; Peiru, W; Weiwei, L; Wen, J

2010-01-01

The authors analyzed the reasons of low efficiency under different operation condition based on the performance test and CFD numerical simulation approach. And the analysis focuses on the relationship between pump efficiency and inner flow characteristics. In order to improve the internal flow and increase efficiency of the pump, some draughting methods of improving the internal flow structure have been proposed, and some new impellers were developed by these methods. The main geometric parameters of the impellers, such as diameter, width and installation of the size, were consistent with the original impeller. The experimental results show that the efficiency of new impellers was improved significantly. The authors' work has opened up a new direction for further improving the efficiency of the low specific speed centrifugal pump.

Impeller radial force evolution in a large double-suction centrifugal pump during startup at the shut-off condition

International Nuclear Information System (INIS)

Zou, Zhichao; Wang, Fujun; Yao, Zhifeng; Tao, Ran; Xiao, Ruofu; Li, Huaicheng

2016-01-01

Highlights: • Conclude the characteristics of transient radial force in the startup process for a large double-suction centrifugal pump. • The overall direction of the radial force during startup process is also confirmed. • A formula used to calculate the transient radial force during startup process is proposed. • A relationship between radial force variation and axial vortex development in blade channel during the startup process is established. The mechanism of the radial force evolution is revealed. - Abstract: Double-suction centrifugal pumps play an important role in the main feedwater systems of nuclear power plant. The impeller radial force in a centrifugal pump varies dramatically during startup at the shut-off condition. In this study, the startup process of a large double-suction centrifugal pump is investigated using CFD. During testing, the impeller speed is accelerated from zero to its rated speed in 1.0 s (marked as t_0) and is then maintained at the rated speed. The results show that the radial force increase lags behind the impeller speed increase. At 0–0.4t_0, the radial force is small (approaching zero). At 0.4–1.4t_0, the radial force increases rapidly. After 1.4t_0, the average radial force stabilizes and reaches its maximum value of 55,619 N. The observed maximum radial force value during startup is approximately nine times as high as the radial force under rated condition. During startup, the overall radial force direction is proximate to the radial line located 25° from the volute tongue along circumferential direction. A transient radial force formula is proposed to evaluate the changes in radial force during startup. The streamline distribution in impeller passages and the impeller outlet pressure profile varying over time are produced. The relationship between radial force evolution and the varying axial-to-spiral vortex structure is analyzed. The radial force change mechanism is revealed. This research provides a scientific

Impeller radial force evolution in a large double-suction centrifugal pump during startup at the shut-off condition

Energy Technology Data Exchange (ETDEWEB)

Zou, Zhichao [College of Water Resources and Civil Engineering, China Agricultural University, Beijing 100083 (China); Wang, Fujun, E-mail: wangfj@cau.edu.cn [College of Water Resources and Civil Engineering, China Agricultural University, Beijing 100083 (China); Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System, China Agricultural University, Beijing 100083 (China); Yao, Zhifeng [College of Water Resources and Civil Engineering, China Agricultural University, Beijing 100083 (China); Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System, China Agricultural University, Beijing 100083 (China); Tao, Ran [College of Water Resources and Civil Engineering, China Agricultural University, Beijing 100083 (China); Xiao, Ruofu [College of Water Resources and Civil Engineering, China Agricultural University, Beijing 100083 (China); Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System, China Agricultural University, Beijing 100083 (China); Li, Huaicheng [Shanghai Liancheng (Group) Co., Ltd., Shanghai 201812 (China)

2016-12-15

Highlights: • Conclude the characteristics of transient radial force in the startup process for a large double-suction centrifugal pump. • The overall direction of the radial force during startup process is also confirmed. • A formula used to calculate the transient radial force during startup process is proposed. • A relationship between radial force variation and axial vortex development in blade channel during the startup process is established. The mechanism of the radial force evolution is revealed. - Abstract: Double-suction centrifugal pumps play an important role in the main feedwater systems of nuclear power plant. The impeller radial force in a centrifugal pump varies dramatically during startup at the shut-off condition. In this study, the startup process of a large double-suction centrifugal pump is investigated using CFD. During testing, the impeller speed is accelerated from zero to its rated speed in 1.0 s (marked as t{sub 0}) and is then maintained at the rated speed. The results show that the radial force increase lags behind the impeller speed increase. At 0–0.4t{sub 0}, the radial force is small (approaching zero). At 0.4–1.4t{sub 0}, the radial force increases rapidly. After 1.4t{sub 0}, the average radial force stabilizes and reaches its maximum value of 55,619 N. The observed maximum radial force value during startup is approximately nine times as high as the radial force under rated condition. During startup, the overall radial force direction is proximate to the radial line located 25° from the volute tongue along circumferential direction. A transient radial force formula is proposed to evaluate the changes in radial force during startup. The streamline distribution in impeller passages and the impeller outlet pressure profile varying over time are produced. The relationship between radial force evolution and the varying axial-to-spiral vortex structure is analyzed. The radial force change mechanism is revealed. This research

Online Monitoring of Large Centrifugal Pumps in Nuclear Power Plants

Energy Technology Data Exchange (ETDEWEB)

Emmanuel, Efenji A.; Faragalla, Mohamed M.; Awwal, Arigi M.; Lee, Yong-kwan [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

2016-10-15

Online Monitoring detects and diagnoses incipient faults, performs predictive maintenance, and can estimate the Remaining Useful Life (RUL) of Active and Passive Components before they fail. In an effort towards assisting Utility Partners to be proactive in the management of their Assets, the Electric Power Research Institute (EPRI) collaborated with the Idaho National Laboratory (INL) to develop a Fleet-Wide Prognostic and Health Monitoring (FW-PHM) Software Suite. The FW-PHM is a web based diagnostic tools and databases designed for use in commercial NPP. The AFS development process as designed by EPRI can be adapted to Large Centrifugal Pumps (LCP) in Nuclear Power Plants (NPP). For the purpose of this endeavor, the set of LCP considered are Safety Class-Motor Driven-Vertical Centrifugal Pumps for primary flow which includes Safety Injection, Containment Spray, and Residual Heat Removal. Fault Signatures of the LCP for OLM has been developed following the INCOSE V-model systems development approach. The fault types, fault features, and their detection methods and effectiveness for the LCP were established by diligently following the guidelines recommended by EPRI. An optimization of the FS for OLM has been suggested for implementation. As a way of extending this work, a Cost-Benefit Analysis between OLM and the conventional Periodic Maintenance for the LCP in NPP is proposed.

Online Monitoring of Large Centrifugal Pumps in Nuclear Power Plants

International Nuclear Information System (INIS)

Emmanuel, Efenji A.; Faragalla, Mohamed M.; Awwal, Arigi M.; Lee, Yong-kwan

2016-01-01

Online Monitoring detects and diagnoses incipient faults, performs predictive maintenance, and can estimate the Remaining Useful Life (RUL) of Active and Passive Components before they fail. In an effort towards assisting Utility Partners to be proactive in the management of their Assets, the Electric Power Research Institute (EPRI) collaborated with the Idaho National Laboratory (INL) to develop a Fleet-Wide Prognostic and Health Monitoring (FW-PHM) Software Suite. The FW-PHM is a web based diagnostic tools and databases designed for use in commercial NPP. The AFS development process as designed by EPRI can be adapted to Large Centrifugal Pumps (LCP) in Nuclear Power Plants (NPP). For the purpose of this endeavor, the set of LCP considered are Safety Class-Motor Driven-Vertical Centrifugal Pumps for primary flow which includes Safety Injection, Containment Spray, and Residual Heat Removal. Fault Signatures of the LCP for OLM has been developed following the INCOSE V-model systems development approach. The fault types, fault features, and their detection methods and effectiveness for the LCP were established by diligently following the guidelines recommended by EPRI. An optimization of the FS for OLM has been suggested for implementation. As a way of extending this work, a Cost-Benefit Analysis between OLM and the conventional Periodic Maintenance for the LCP in NPP is proposed

Numerical simulation on dimension decrease for annular casing of one centrifugal boiler circulation pump

International Nuclear Information System (INIS)

Fan, Y Z; Zuo, Z G; Liu, S H; Wu, Y L; Sha, Y J

2012-01-01

Primary formulation derivation indicates that the dimension of one existing centrifugal boiler circulation pump casing is too large. As great manufacture cost can be saved by dimension decrease, a numerical simulation research is developed in this paper on dimension decrease for annular casing of this pump with a specific speed equaling to 189, which aims at finding an appropriately smaller dimension of the casing while hydraulic performance and strength performance will hardly be changed according to the requirements of the cooperative company. The research object is one existing centrifugal pump with a diffuser and a semi-spherical annular casing, working as the boiler circulation pump for (ultra) supercritical units in power plants. Dimension decrease, the modification method, is achieved by decreasing the existing casing's internal radius (marked as R i0 ) while keeping the wall thickness. The research analysis is based on primary formulation derivation, CFD (Computational Fluid Dynamics) simulation and FEM (Finite Element Method) simulation. Primary formulation derivation estimates that a design casing's internal radius should be less than 0.75 R i0 . CFD analysis indicates that smaller casing with 0.75 R i0 has a worse hydraulic performance when working at large flow rates and a better hydraulic performance when working at small flow rates. In consideration of hydraulic performance and dimension decrease, an appropriate casing's internal radius is determined, which equals to 0.875 R i0 . FEM analysis then confirms that modified pump casing has nearly the same strength performance as the existing pump casing. It is concluded that dimension decrease can be an economical method as well as a practical method for large pumps in engineering fields.

Numerical simulation on dimension decrease for annular casing of one centrifugal boiler circulation pump

Science.gov (United States)

Fan, Y. Z.; Zuo, Z. G.; Liu, S. H.; Wu, Y. L.; Sha, Y. J.

2012-11-01

Primary formulation derivation indicates that the dimension of one existing centrifugal boiler circulation pump casing is too large. As great manufacture cost can be saved by dimension decrease, a numerical simulation research is developed in this paper on dimension decrease for annular casing of this pump with a specific speed equaling to 189, which aims at finding an appropriately smaller dimension of the casing while hydraulic performance and strength performance will hardly be changed according to the requirements of the cooperative company. The research object is one existing centrifugal pump with a diffuser and a semi-spherical annular casing, working as the boiler circulation pump for (ultra) supercritical units in power plants. Dimension decrease, the modification method, is achieved by decreasing the existing casing's internal radius (marked as "Ri0") while keeping the wall thickness. The research analysis is based on primary formulation derivation, CFD (Computational Fluid Dynamics) simulation and FEM (Finite Element Method) simulation. Primary formulation derivation estimates that a design casing's internal radius should be less than 0.75 Ri0. CFD analysis indicates that smaller casing with 0.75 Ri0 has a worse hydraulic performance when working at large flow rates and a better hydraulic performance when working at small flow rates. In consideration of hydraulic performance and dimension decrease, an appropriate casing's internal radius is determined, which equals to 0.875 Ri0. FEM analysis then confirms that modified pump casing has nearly the same strength performance as the existing pump casing. It is concluded that dimension decrease can be an economical method as well as a practical method for large pumps in engineering fields.

Rotary piston blood pumps: past developments and future potential of a unique pump type.

Science.gov (United States)

Wappenschmidt, Johannes; Autschbach, Rüdiger; Steinseifer, Ulrich; Schmitz-Rode, Thomas; Margreiter, Raimund; Klima, Günter; Goetzenich, Andreas

2016-08-01

The design of implantable blood pumps is either based on displacement pumps with membranes or rotary pumps. Both pump types have limitations to meet the clinical requirements. Rotary piston blood pumps have the potential to overcome these limitations and to merge the benefits. Compared to membrane pumps, they are smaller and with no need for wear-affected membranes and valves. Compared to rotary pumps, the blood flow is pulsatile instead of a non-physiological continuous flow. Furthermore, the risk of flow-induced blood damage and platelet activation may be reduced due to low shear stress to the blood. The past developments of rotary piston blood pumps are summarized and the main problem for long-term application is identified: insufficient seals. A new approach with seal-less drives is proposed and current research on a simplified rotary piston design is presented. Expert commentary: The development of blood pumps focuses mainly on the improvement of rotary pumps. However, medical complications indicate that inherent limitations of this pump type remain and restrict the next substantial step forward in the therapy of heart failure patients. Thus, research on different pump types is reasonable. If the development of reliable drives and bearings succeeds, rotary piston blood pumps become a promising alternative.

Effect of hypergravity on catecholamine levels in telemetrically collected blood of rats during centrifugation

Science.gov (United States)

Kvetnansky, R.; Petrak, J.; Mravec, B.; Tillinger, A.; Jurani, M.; Baranovska, M.; Hapala, I.; Frollo, I.

2005-08-01

Hypergravity is known to activate the sympathoadrenal system (SAS). Rats subjected to various accelerations (+G) exhibited increased levels of plasma epinephrine (EPI) and partly also norepinephrine (NE). However, the collection of blood was performed after centrifugation finished and therefore plasma NE and EPI levels could have been affected by the process of deceleration. The aim of this study was to evaluate plasma EPI and NE levels in blood collected directly during the centrifugation after reaching different +G, using newly developed remote controlled equipment. Such telemetrically regulated equipment for multiple blood sampling allows us to investigate selective effects of hypergravity during centrifugation. All animals had a polyethylene tubing in the tail artery which was connected to a pre-programmed device for three blood withdrawals (0.6 ml each) into individual syringes, performed at any chosen time intervals. Plasma EPI and NE levels were measured at hypergravity between +1G - +5G. Plasma EPI levels showed a huge, hypergravity dependent increase at the interval of 10-20 min. After the blood collection was completed, the centrifuge was turned off and another blood sampling was performed immediately after the centrifuge stopped (10 min). In these samples plasma EPI levels showed a significant reduction compared to the 20 min interval of centrifugation but the EPI levels at 4G-6G were still significantly elevated compared to pre- centrifugation levels. Plasma NE levels showed less pronounced changes (increased after 6G only) with a slower return to control levels.Thus, our data has shown completely different responses of the adrenomedullary (epinephrine) and sympathoneural (norepinephrine) systems to hypergravitation. This data shows that the increased gravitation and not the stressful situations connected with centrifugation is the factor responsible for massive activation of the adrenomedullary system. The mechanism of small activation of the

Detection of cavitation inception by acoustic technique in centrifugal pumps for nuclear application

International Nuclear Information System (INIS)

Prakash, V.; Prabhakar, R.; Rao, A.S.L.K.; Kale, R.D.

1994-01-01

The primary centrifugal pumps in a pool type reactor like the proposed Prototype Fast Breeder Reactor (PFBR) are required to operate at low values of available net positive suction head due to the limited submergence available in the pool. Pump hydraulics are designed to ensure that there is no cavitation or only minimum cavitation in the pump impeller in order to minimise long term erosion damage. Rigorous cavitation tests are usually carried out during development and final testing phase and a promising cavitation detection technique lies in acoustic noise measurements on the pump. As part of PFBR pump development programme, cavitation noise measurements were initially carried out on an experimental sodium pump in a water rig to establish detection procedures. Recently cavitation noise measurements were carried out on a 1/3 scale model impeller of PFBR pump along with visual observation of impeller passages to establish a correlation between visual and acoustic technique. Accelerometer responding to structure borne noise seems to give the best result. (author). 4 refs., 6 figs

Leukoreduction by centrifugation does not eliminate Trypanosoma cruzi from infected blood units.

Science.gov (United States)

Dzib, Doris; Hernández, Virginia Peña; Ake, Baldemar Canche; López, Ruth Alacantara; Monteón, Victor Manuel

2009-06-01

Current strategies to prevent transfusion-associated Chagas disease include the identification of Trypanosoma cruzi-infected blood donors through questionnaires and serologic tests. There are other procedures such as leukoreduction that prevent the transmission of infectious agents associated to white cells. The objective of the present work was to estimate the seroprevalence, evaluate the efficacy of leukoreduction by centrifugation to eliminate T. cruzi in infected blood units, and the correlation of immunoglobulin G (IgG) subclasses of seropositive blood donors with chronic chagasic cardiopathy. Over a period of 14 months, 33 out of 6600 blood donors (0.5%) at Centro Estatal de la Transfusión Sanguínea in Campeche State, México were seropositive for T. cruzi. Twenty seropositive blood units were submitted through leukoreduction by centrifugation, and in the fractions generated (red cell fraction, platelets, and the buffy-coat), we searched for the presence of T. cruzi using specific polymerase chain reaction. We detected parasite DNA in 50% to 60% of the fractions tested, suggesting that leukoreduction by centrifugation does not eliminate the microorganisms in the infected blood unit. We also observed that the level of IgG2 and IgG4 subclasses specific for T. cruzi in seropositive blood donors was lower than in chronic cardiopathic chagasic patients. In conclusion, leukoreduction by centrifugation has a limited role in eliminating T. cruzi in infected blood supply, and the low level of specific IgG2 and IgG4 could be a marker in the indeterminate phase of infection.

Fresenius AS.TEC204 blood cell separator.

Science.gov (United States)

Sugai, Mikiya

2003-02-01

Fresenius AS.TEC204 is a third-generation blood cell separator that incorporates the continuous centrifugal separation method and automatic control of the cell separation process. Continuous centrifugation separates cell components according to their specific gravity, and different cell components are either harvested or eliminated as needed. The interface between the red blood cell and plasma is optically detected, and the Interface Control (IFC) cooperates with different pumps, monitors and detectors to harvest required components automatically. The system is composed of three major sections; the Front Panel Unit; the Pump Unit, and the Centrifuge Unit. This unit can be used for a wide variety of clinical applications including collection of platelets, peripheral blood stem cells, bone marrow stem cells, granulocytes, mononuclear cells, and exchange of plasma or red cells, and for plasma treatment.

Heat generation and hemolysis at the shaft seal in centrifugal blood pumps.

Science.gov (United States)

Araki, K; Taenaka, Y; Wakisaka, Y; Masuzawa, T; Tatsumi, E; Nakatani, T; Baba, Y; Yagura, A; Eya, K; Toda, K

1995-01-01

The heat and hemolysis around a shaft seal were investigated. Materials were original pumps (Nikkiso HMS-15:N-original, and 3M Delphin:D-original), vane-removed pumps (Nvane(-), Dvane(-)), and a small chamber with a shaft coiled by nichrome wire (mock pump). The original pumps were driven at 500 mmHg and 5 L/min, and vane-removed pumps were driven at the same rotation number. An electrical powers of 0, 0.5, 2, and 10 W was supplied to the mock pumps. In vitro hemolytic testing showed that hemolytic indices were 0.027 g/100 L in N-original, 0.013 in Nvane(-), 0.061 in D-original, and 0.012 in Dvane(-). Measurement of heat with a thermally insulated water chamber showed total heat within the pump of 8.62 and 10.85 W, and heat at the shaft seal of 0.87 and 0.62 W in the Nikkiso and Delphin pumps, respectively. Hemolysis and heat generation of mock pumps remained low. The results indicate that the heat generated around the shaft seal was minimal. Hemolysis at the shaft-seal was considerable but not major. Local heat did not affect hemolysis. It was concluded that the shaft-seal affected hemolysis, not by local heat but friction itself.

Numerical Investigation of Periodically Unsteady Pressure Field in a High Power Centrifugal Diffuser Pump

Directory of Open Access Journals (Sweden)

Ji Pei

2014-05-01

Full Text Available Pressure fluctuations are the main factors that can give rise to reliability problems in centrifugal pumps. The periodically unsteady pressure characteristics caused by rotor-stator interaction have been investigated by CFD calculation in a residual heat removal pump. Side chamber flow effect is also considered for the simulation to accurately predict the flow in whole flow passage. The pressure fluctuation results in time and frequency domains were considered for several typical monitoring points in impeller and diffuser channels. In addition, the pressure fluctuation intensity coefficient (PFIC based on standard deviation was defined on each grid node for entire space and impeller revolution period. The results show that strong pressure fluctuation intensity can be found in the gap between impeller and diffuser. As a source, the fluctuation can spread to the upstream and downstream flow channels as well as the side chamber channels. Meanwhile, strong pressure fluctuation intensity can be found in the discharge tube of the circular casing. In addition, the obvious influence of operational flow rate on the PFIC distribution can be found. The analysis indicates that the pressure fluctuations in the aspects of both frequency and intensity can be used to comprehensively evaluate the unsteady pressure characteristics in centrifugal pumps.

Isolation of Mycobacterium chelonei with the lysis-centrifugation blood culture technique.

OpenAIRE

Fojtasek, M F; Kelly, M T

1982-01-01

Mycobacterium chelonei was isolated from a patient by the lysis-centrifugation and the conventional two-bottle blood culture methods. The lysis-centrifugation method was significantly more sensitive and rapid than the conventional method in detecting and isolating this organism; quantitations done by this method were useful for monitoring response to therapy.

Experimental investigations on a common centrifugal pump operating under gas entrainment conditions

Energy Technology Data Exchange (ETDEWEB)

Schäfer, Thomas, E-mail: thomas.schaefer@hzdr.de [Helmholtz-Zentrum Dresden-Rossendorf, Institute of Fluid Dynamics (Germany); Neumann, Martin [Technische Universität Dresden, AREVA Endowed Chair of Imaging Techniques in Energy and Process Engineering (Germany); Bieberle, André [Helmholtz-Zentrum Dresden-Rossendorf, Institute of Fluid Dynamics (Germany); Hampel, Uwe [Helmholtz-Zentrum Dresden-Rossendorf, Institute of Fluid Dynamics (Germany); Technische Universität Dresden, AREVA Endowed Chair of Imaging Techniques in Energy and Process Engineering (Germany)

2017-05-15

Highlights: • The pump performance has been evaluated for several gas entrainment conditions. • The gas entraining flow regime has a large impact on the pump performance. • High-resolution gamma-ray computed tomography (HireCT) has been applied. • Gas holdup inside the operating impeller has been visualized and quantified. • Gas holdup profiles along selected streamlines have been calculated. - Abstract: This paper presents an experimental study on the effects of additional gas entrainment in centrifugal pumps designed for conveying liquid phases only. The pump performance has been evaluated for several gas entrainment conditions, and for various operational settings of the pump, such as its alignment and the rotational speed of the impeller. As a main performance indicator the impact of entrained gas on the hydraulic power of the pump has been analyzed using experimental data. Additionally, high-resolution gamma-ray computed tomography (HireCT) operated in time-averaged rotation-synchronized scanning mode has been applied to quantify local phase fraction distributions inside the rapidly rotating pump impeller. Based on these quantitative tomographic measurements, gas holdup profiles along selected streamlines have been calculated and gas accumulation areas inside the impeller chambers have been visualized. Thus, various internally accumulated gas holdup patterns have been identified and, eventually, associated with characteristic pump performance behaviors. Moreover, the tomographic measuring method allowed an enhanced gas holdup analysis in specified pump compartments. As a result, the related specific gas and liquid phase holdup profiles have been evaluated.

Experimental investigations on a common centrifugal pump operating under gas entrainment conditions

International Nuclear Information System (INIS)

Schäfer, Thomas; Neumann, Martin; Bieberle, André; Hampel, Uwe

2017-01-01

Highlights: • The pump performance has been evaluated for several gas entrainment conditions. • The gas entraining flow regime has a large impact on the pump performance. • High-resolution gamma-ray computed tomography (HireCT) has been applied. • Gas holdup inside the operating impeller has been visualized and quantified. • Gas holdup profiles along selected streamlines have been calculated. - Abstract: This paper presents an experimental study on the effects of additional gas entrainment in centrifugal pumps designed for conveying liquid phases only. The pump performance has been evaluated for several gas entrainment conditions, and for various operational settings of the pump, such as its alignment and the rotational speed of the impeller. As a main performance indicator the impact of entrained gas on the hydraulic power of the pump has been analyzed using experimental data. Additionally, high-resolution gamma-ray computed tomography (HireCT) operated in time-averaged rotation-synchronized scanning mode has been applied to quantify local phase fraction distributions inside the rapidly rotating pump impeller. Based on these quantitative tomographic measurements, gas holdup profiles along selected streamlines have been calculated and gas accumulation areas inside the impeller chambers have been visualized. Thus, various internally accumulated gas holdup patterns have been identified and, eventually, associated with characteristic pump performance behaviors. Moreover, the tomographic measuring method allowed an enhanced gas holdup analysis in specified pump compartments. As a result, the related specific gas and liquid phase holdup profiles have been evaluated.

VENTRICLE ASSIST DEVICE: PAST, PRESENT, AND FUTURE NONPULSATILE PUMPS

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G. Р. Itkin

2009-01-01

Full Text Available The article briefly describes the history of the non-pulsating type blood pumps for ventricular assist circulation and heart-lung machine. Disclosed the main advantages of these pumps before pulsating type, especially for implantable systems development. However, disadvantages of these pumps and the directions of minimize or eliminate ones have shown. Specific examples of our implantable centrifugal and axial pump developments are presented. Declare the ways to further improve the pumps. 

Novel maglev pump with a combined magnetic bearing.

Science.gov (United States)

Onuma, Hiroyuki; Murakami, Michiko; Masuzawa, Toru

2005-01-01

The newly developed pump is a magnetically levitated centrifugal blood pump in which active and passive magnetic bearings are integrated to construct a durable ventricular assist device. The developed maglev centrifugal pump consists of an active magnetic bearing, a passive magnetic bearing, a levitated impeller, and a motor stator. The impeller is set between the active magnetic bearing and the motor stator. The active magnetic bearing uses four electromagnets to control the tilt and the axial position of the impeller. The radial movement of the levitated impeller is restricted with the passive stability dependent upon the top stator and the passive permanent magnetic bearing to reduce the energy consumption and the control system complexity. The top stator was designed based upon a magnetic field analysis to develop the maglev pump with sufficient passive stability in the radial direction. By implementing this analysis design, the oscillating amplitude of the impeller in the radial direction was cut in half when compared with the simple shape stator. This study concluded that the newly developed maglev centrifugal pump displayed excellent levitation performance and sufficient pump performance as a ventricular assist device.

Numerical Investigations of Unsteady Flow in a Centrifugal Pump with a Vaned Diffuser

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Olivier Petit

2013-01-01

Full Text Available Computational fluid dynamics (CFD analyses were made to study the unsteady three-dimensional turbulence in the ERCOFTAC centrifugal pump test case. The simulations were carried out using the OpenFOAM Open Source CFD software. The test case consists of an unshrouded centrifugal impeller with seven blades and a radial vaned diffuser with 12 vanes. A large number of measurements are available in the radial gap between the impeller and the diffuse, making this case ideal for validating numerical methods. Results of steady and unsteady calculations of the flow in the pump are compared with the experimental ones, and four different turbulent models are analyzed. The steady simulation uses the frozen rotor concept, while the unsteady simulation uses a fully resolved sliding grid approach. The comparisons show that the unsteady numerical results accurately predict the unsteadiness of the flow, demonstrating the validity and applicability of that methodology for unsteady incompressible turbomachinery flow computations. The steady approach is less accurate, with an unphysical advection of the impeller wakes, but accurate enough for a crude approximation. The different turbulence models predict the flow at the same level of accuracy, with slightly different results.

Hypergravity-induced increase in plasma catecholamine and corticosterone levels in telemetrically collected blood of rats during centrifugation.

Science.gov (United States)

Petrak, Juraj; Mravec, Boris; Jurani, Marian; Baranovska, Magda; Tillinger, Andrej; Hapala, Ivan; Frollo, Ivan; Kvetnanský, Richard

2008-12-01

Rats subjected to various accelerations (+G) exhibited increased levels of plasma epinephrine (EPI), norepinephrine (NE), and corticosterone. However, the collection of blood was performed after a centrifugation finished, and therefore the levels could be affected by the process of deceleration. The aim of this study was to evaluate plasma EPI, NE, and corticosterone levels in blood collected directly during centrifugation after reaching different G (2-6), using newly developed remote-controlled equipment. Animals placed into the centrifuge cabins had inserted polyethylene tubing in the tail artery, which was connected with a preprogrammed device for blood withdrawals. Plasma EPI, NE, and corticosterone levels were measured at different time intervals of hypergravity of 2-6G. Plasma EPI levels showed a huge, hypergravity-level-dependent increase. After the last blood collection was completed during hypergravity, the centrifuge was turned off and another blood sampling was performed immediately after the centrifuge stopped (10 min). In these samples, plasma EPI showed significantly lower levels compared to centrifugation intervals. Plasma NE levels were significantly increased after 6G only. The increase in plasma corticosterone was dependent on level of G, however after the centrifuge stopped, corticosterone levels remained elevated. Thus, our data show that hypergravity highly activates the adrenomedullary and hypothalamo-pituitary-adrenocortical systems, whereas the sympathoneural system is activated only at high hypergravity. Immediately after centrifugation is over, EPI levels quickly return to control values. Our technique of blood collection during centrifugation allows assessment of the real hormonal levels at the particular hypergravity value.

The Tin Coatings Utilisation As Blood Contact Surface Modification In Implantable Rotary Left Ventricle Assist Device Religaheart Rot

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Kustosz R.

2015-09-01

Full Text Available Constructions of the mechanical-bearingless centrifugal blood pumps utilize different types of non-contact physical bearings, which allows to balance the forces that have an impact on the pump impeller, stabilizing its position in the pump house without wall contact. The paper presents investigations of the hybrid (passive magnetic bearings and hydrodynamic bearings suspension system for the centrifugal blood pump. Numerical simulations were used to evaluate the hydrodynamic bearing lifting force and magnetic bearing forces interaction. An important aspect of rotor suspension system design was the nominal gap in hydrodynamic bearing area in order to reduce the blood damage risk in this region. The analyses results confirmed that for a small diameter centrifugal pump, the nominal operating hydrodynamic bearing gap could be established within the range from 0.033 to 0.072 mm.

Investigation on the influence of jetting equipment on the characteristics of centrifugal pump

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Qiaorui Si

2016-08-01

Full Text Available To reduce radial noises from the motor of centrifugal pumps, this study designed a water cooling system called jetting equipment to replace traditional fan cooling systems in pump motors. By measuring radiated noises, head, efficiency, and cavitation performance, the research compared the differences among experimental results of the original pump unit, the one with a normal design jetting pipe and another one with a larger jetting pipe. Results show that the radiated sound pressure level of the model pump was significantly reduced by 8.3 dB after integrating the jetting pipe. With a normal jetting pipe, no significant changes were observed in the head, efficiency, and shaft power curves, and cavitation performance improved under small flow rate. However, the performance with the larger jetting pipe worsened, except the hump phenomenon of the model pump under a small flow rate was enhanced. Computational fluid dynamics method was used to calculate the internal flow of three model pumps in order to investigate the jetting flow effect. A comparison among the flow fields at the inlet of the three types of pumps indicated that high-pressure water injection can effectively control inlet recirculation and improve velocity distribution in the inlet flow field with decreased recirculation vortex strength and recirculation onset critical flow rate.

Experimental study of centrifugal pump performance under steam-water two-phase flow conditions at elevated pressures

International Nuclear Information System (INIS)

Chan, A.M.C.; Barreca, S.L.; Hartlen, R.T.

1991-01-01

The performance of a centrifugal pump under two-phase flow conditions was studied in a closed loop. System voids of increasing magnitude were attained by draining water from the loop in steps. The operating temperature/pressure were varied from 110 degrees C/0.15 MPa to 260 degrees C/4.7 MPa. Only tests in the first quadrant were conducted. In this paper the head-flow characteristics and pump head degradation data are presented and discussed

Numerical Investigation on a Prototype Centrifugal Pump Subjected to Fluctuating Rotational Speed

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Yu-Liang Zhang

2014-01-01

Full Text Available The rotational speed of pumps often encounters fluctuation in engineering for some reasons. In this paper, in order to study the transient response characteristic of a prototype centrifugal pump subjected to fluctuating rotational speed, a closed-loop pipe system including the pump is built to accomplish unsteady flow calculations in which the boundary conditions at the inlet and the outlet of the pump are not required to be set. The external performance results show that the head’s responsiveness to the fluctuating rotational speed is very good, while the flow rate’s responsiveness is slightly delayed. The variation tendencies of the static pressures at the inlet and the outlet of the pump are almost completely opposite, wherein the variation tendency of the static pressure at the outlet is identical with that of the rotational speed. The intensity of the turbulence energy in each impeller channel is relatively uniform in the transient flow calculations, while, in the quasi-steady flow calculation, it becomes weaker in a channel closed to the volute tongue. The nondimensional flow rate and head coefficients are dependent on the rotational speed, and their variation tendencies are opposite to that of the fluctuating rotational speed as a whole.

Numerical Simulation of 3D Solid-Liquid Turbulent Flow in a Low Specific Speed Centrifugal Pump: Flow Field Analysis

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Baocheng Shi

2014-06-01

Full Text Available For numerically simulating 3D solid-liquid turbulent flow in low specific speed centrifugal pumps, the iteration convergence problem caused by complex internal structure and high rotational speed of pump is always a problem for numeral simulation researchers. To solve this problem, the combination of three measures of dynamic underrelaxation factor adjustment, step method, and rotational velocity control means according to residual curves trends of operating parameters was used to improve the numerical convergence. Numeral simulation of 3D turbulent flow in a low specific speed solid-liquid centrifugal pump was performed, and the results showed that the improved solution strategy is greatly helpful to the numerical convergence. Moreover, the 3D turbulent flow fields in pumps have been simulated for the bottom ash-particles with the volume fraction of 10%, 20%, and 30% at the same particle diameter of 0.1 mm. The two-phase calculation results are compared with those of single-phase clean water flow. The calculated results gave the main region of the abrasion of the impeller and volute casing and improve the hydraulic design of the impeller in order to decrease the abrasion and increase the service life of the pump.

Evaluation of near-wall solution approaches for large-eddy simulations of flow in a centrifugal pump impeller

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Zhi-Feng Yao

2016-01-01

Full Text Available The turbulent flow in a centrifugal pump impeller is bounded by complex surfaces, including blades, a hub and a shroud. The primary challenge of the flow simulation arises from the generation of a boundary layer between the surface of the impeller and the moving fluid. The principal objective is to evaluate the near-wall solution approaches that are typically used to deal with the flow in the boundary layer for the large-eddy simulation (LES of a centrifugal pump impeller. Three near-wall solution approaches –the wall-function approach, the wall-resolved approach and the hybrid Reynolds averaged Navier–Stoke (RANS and LES approach – are tested. The simulation results are compared with experimental results conducted through particle imaging velocimetry (PIV and laser Doppler velocimetry (LDV. It is found that the wall-function approach is more sparing of computational resources, while the other two approaches have the important advantage of providing highly accurate boundary layer flow prediction. The hybrid RANS/LES approach is suitable for predicting steady-flow features, such as time-averaged velocities and hydraulic losses. Despite the fact that the wall-resolved approach is expensive in terms of computing resources, it exhibits a strong ability to capture a small-scale vortex and predict instantaneous velocity in the near-wall region in the impeller. The wall-resolved approach is thus recommended for the transient simulation of flows in centrifugal pump impellers.

Numerical Investigation of Transient Flow in a Prototype Centrifugal Pump during Startup Period

Science.gov (United States)

Zhang, Yu-Liang; Zhu, Zu-Chao; Dou, Hua-Shu; Cui, Bao-Ling; Li, Yi; Zhou, Zhao-Zhong

2017-05-01

Transient performance of pumps during transient operating periods, such as startup and stopping, has drawn more and more attentions recently due to the growing engineering needs. During the startup period of a pump, the performance parameters such as the flow rate and head would vary significantly in a broad range. Therefore, it is very difficult to accurately specify the unsteady boundary conditions for a pump alone to solve the transient flow in the absence of experimental results. The closed-loop pipe system including a centrifugal pump is built to accomplish the self-coupling calculation. The three-dimensional unsteady incompressible viscous flow inside the passage of the pump during startup period is numerically simulated using the dynamic mesh method. Simulation results show that there are tiny fluctuations in the flow rate even under stable operating conditions and this can be attributed to influence of the rotor-stator interaction. At the very beginning of the startup, the rising speed of the flow rate is lower than that of the rotational speed. It is also found that it is not suitable to predict the transient performance of pumps using the calculation method of quasi-steady flow, especially at the earlier period of the startup.

21 CFR 870.4360 - Nonroller-type cardiopulmonary bypass blood pump.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Nonroller-type cardiopulmonary bypass blood pump... Nonroller-type cardiopulmonary bypass blood pump. (a) Identification. A nonroller-type cardiopulmonary bypass blood pump is a device that uses a method other than revolving rollers to pump the blood through...

21 CFR 870.4370 - Roller-type cardiopulmonary bypass blood pump.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Roller-type cardiopulmonary bypass blood pump. 870... Roller-type cardiopulmonary bypass blood pump. (a) Identification. A roller-type cardiopulmonary bypass blood pump is a device that uses a revolving roller mechanism to pump the blood through the...

Suppression of the secondary flow in a suction channel of a large centrifugal pump

International Nuclear Information System (INIS)

Torii, D; Nagahara, T; Okihara, T

2013-01-01

The suction channel configuration of a large centrifugal pump with a 90-degree bend was studied in detail to suppress the secondary flow at the impeller inlet for improving suction performance. Design of experiments (DOE) and computational fluid dynamics (CFD) were used to evaluate the sensitivity of several primary design parameters of the suction channel. A DOE is a powerful tool to clarify the sensitivity of objective functions to design parameters with a minimum of trials. An L9 orthogonal array was adopted in this study and nine suction channels were designed, through which the flow was predicted by steady state calculation. The results indicate that a smaller bend radius with a longer straight nozzle, distributed between the bend and the impeller, suppresses the secondary flow at the impeller inlet. An optimum ratio of the cross sectional areas at the bend inlet and outlet was also confirmed in relationship to the contraction rate of the downstream straight nozzle. These findings were obtained by CFD and verified by experiments. The results will aid the design of large centrifugal pumps with better suction performance and higher reliability

Vacuum chamber-free centrifuge with magnetic bearings.

Science.gov (United States)

Park, Cheol Hoon; Kim, Soohyun; Kim, Kyung-Soo

2013-09-01

Centrifuges are devices that separate particles of different densities and sizes through the application of a centrifugal force. If a centrifuge could be operated under atmospheric conditions, all vacuum-related components such as the vacuum chamber, vacuum pump, diffusion pump, and sealing could be removed from a conventional centrifuge system. The design and manufacturing procedure for centrifuges could then be greatly simplified to facilitate the production of lightweight centrifuge systems of smaller volume. Furthermore, the maintenance costs incurred owing to wear and tear due to conventional ball bearings would be eliminated. In this study, we describe a novel vacuum chamber-free centrifuge supported by magnetic bearings. We demonstrate the feasibility of the vacuum chamber-free centrifuge by presenting experimental results that verify its high-speed support capability and motoring power capacity.

Comparison of lysis-centrifugation with lysis-filtration and a conventional unvented bottle for blood cultures.

OpenAIRE

Gill, V J; Zierdt, C H; Wu, T C; Stock, F; Pizzo, P A; MacLowry, J D

1984-01-01

Evaluation of a commercially available lysis-centrifugation blood culture system (Isolator, DuPont Co., Wilmington, Del.) and a lysis-filtration blood culture system for 3,111 cultures showed that both methods had comparable recoveries (73 and 68%, respectively) of significant aerobic and facultatively anaerobic isolates. The unvented conventional blood culture bottle had a recovery rate of 59%. Although the lysis-centrifugation and lysis-filtration systems had comparable recoveries of pathog...

Simulation of a Centrifugal Pump by Using the Harmonic Balance Method

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Franco Magagnato

2015-01-01

Full Text Available The harmonic balance method was used for the flow simulation in a centrifugal pump. Independence studies have been done to choose proper number of harmonic modes and inlet eddy viscosity ratio value. The results from harmonic balance method show good agreements with PIV experiments and unsteady calculation results (which is based on the dual time stepping method for the predicted head and the phase-averaged velocity. A detailed analysis of the flow fields at different flow rates shows that the flow rate has an evident influence on the flow fields. At 0.6Qd, some vortices begin to appear in the impeller, and at 0.4Qd some vortices have blocked the flow passage. The flow fields at different positions at 0.6Qd and 0.4Qd show how the complicated flow phenomena are forming, developing, and even disappearing. The harmonic balance method can be used for the flow simulation in pumps, showing the same accuracy as unsteady methods, but is considerably faster.

Mycobacterium tuberculosis bacteremia detected by the Isolator lysis-centrifugation blood culture system.

OpenAIRE

Kiehn, T E; Gold, J W; Brannon, P; Timberger, R J; Armstrong, D

1985-01-01

Mycobacterium tuberculosis was detected by the Isolator lysis-centrifugation blood culture system from the blood of a patient with tuberculosis of the breast. The organism also grew on conventional laboratory media inoculated with pleural fluid from the patient.

A portable system for processing donated whole blood into high quality components without centrifugation.

Science.gov (United States)

Gifford, Sean C; Strachan, Briony C; Xia, Hui; Vörös, Eszter; Torabian, Kian; Tomasino, Taylor A; Griffin, Gary D; Lichtiger, Benjamin; Aung, Fleur M; Shevkoplyas, Sergey S

2018-01-01

The use of centrifugation-based approaches for processing donated blood into components is routine in the industrialized world, as disparate storage conditions require the rapid separation of 'whole blood' into distinct red blood cell (RBC), platelet, and plasma products. However, the logistical complications and potential cellular damage associated with centrifugation/apheresis manufacturing of blood products are well documented. The objective of this study was to evaluate a proof-of-concept system for whole blood processing, which does not employ electromechanical parts, is easily portable, and can be operated immediately after donation with minimal human labor. In a split-unit study (n = 6), full (~500mL) units of freshly-donated whole blood were divided, with one half processed by conventional centrifugation techniques and the other with the new blood separation system. Each of these processes took 2-3 hours to complete and were performed in parallel. Blood products generated by the two approaches were compared using an extensive panel of cellular and plasma quality metrics. Comparison of nearly all RBC parameters showed no significant differences between the two approaches, although the portable system generated RBC units with a slight but statistically significant improvement in 2,3-diphosphoglyceric acid concentration (p applications in remote or resource-limited settings, or for patients requiring highly functional platelet product.

Numerical Research about Influence of Blade Outlet Angle on Flow-Induced Noise and Vibration for Centrifugal Pump

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Ailing Yang

2014-03-01

Full Text Available A hybrid numerical method was used to calculate the flow-induced noise and vibration of the centrifugal pump in the paper. The unsteady flows inside the centrifugal pumps with different blade outlet angles were simulated firstly. The unsteady pressure on the inner surface of the volute and the unsteady force applied on the impeller were analyzed. Then the vibration of the volute and sound field were calculated based on an acoustic-vibro-coupling method. The results show that the pump head has increased 7% while the hydraulic efficiency decreased 11.75% as blade outlet angles increased from 18° to 39°. The amplitude of pressure fluctuation at the first blade passing frequency has decreased but increased at the second-order blade passing frequency as the angle growing. The total fluctuation power near volute tongue goes up about 12% every 3° increment of blade outlet angle. The results also show that vibrating-velocity of the volute at second-order blade passing frequency is much higher than at other frequencies, and the velocity increases rapidly as blade outlet angle varies from 18° to 39°. At the same time, the sound pressure level outside the pump has increased about 8.6 dB when the angle increased from 18° to 39°.

Pump Application as Hydraulic Turbine – Pump as Turbine (PaT)

OpenAIRE

Rusovs, D

2009-01-01

The paper considers pump operation as hydraulic turbine with purpose to produce mechanical power from liquid flow. The Francis hydraulic turbine was selected for comparison with centrifugal pump in reverse operation. Turbine and centrifugal pump velocity triangles were considered with purpose to evaluate PaT efficiency. Shape of impeller blades for turbine and pumps was analysed. Specific speed calculation is carried out with purpose to obtain similarity in pump and turbine description. For ...

Rapid prototyping of centrifugal microfluidic modules for point of care blood testing

CSIR Research Space (South Africa)

Madzivhandila, Phophi

2016-11-01

Full Text Available We present modular centrifugal microfluidic devices that enable a series of blood tests to be performed towards a full blood count. The modular approach allows for rapid prototyping of device components in a generic format to complete different...

Origins of hydrodynamic forces on centrifugal pump impellers

Science.gov (United States)

Adkins, Douglas R.; Brennen, Christopher E.

1987-01-01

Hydrodynamic interactions that occur between a centrifugal pump impeller and volute are experimentally and theoretically investigated. The theoretical analysis considers the inability of the blades to perfectly guide the flow through the impeller, and also includes a quasi-one dimensional treatment of the flow in the volute. The disturbance at the impeller discharge and the resulting forces are determined by the theoretical model. The model is then extended to obtain the hydrodynamic force perturbations that are caused by the impeller whirling eccentrically in the volute. Under many operating conditions, these force perturbations were found to be destablizing. Comparisons are made between the theoretical model and the experimental measurements of pressure distributions and radial forces on the impeller. The theoretical model yields fairly accurate predictions of the radial forces caused by the flow through the impeller. However, it was found that the pressure acting on the front shroud of the impeller has a substantial effect on the destablizing hydrodynamic forces.

Comparison of the lysis centrifugation method with the conventional blood culture method in cases of sepsis in a tertiary care hospital.

Science.gov (United States)

Parikh, Harshal R; De, Anuradha S; Baveja, Sujata M

2012-07-01

Physicians and microbiologists have long recognized that the presence of living microorganisms in the blood of a patient carries with it considerable morbidity and mortality. Hence, blood cultures have become critically important and frequently performed test in clinical microbiology laboratories for diagnosis of sepsis. To compare the conventional blood culture method with the lysis centrifugation method in cases of sepsis. Two hundred nonduplicate blood cultures from cases of sepsis were analyzed using two blood culture methods concurrently for recovery of bacteria from patients diagnosed clinically with sepsis - the conventional blood culture method using trypticase soy broth and the lysis centrifugation method using saponin by centrifuging at 3000 g for 30 minutes. Overall bacteria recovered from 200 blood cultures were 17.5%. The conventional blood culture method had a higher yield of organisms, especially Gram positive cocci. The lysis centrifugation method was comparable with the former method with respect to Gram negative bacilli. The sensitivity of lysis centrifugation method in comparison to conventional blood culture method was 49.75% in this study, specificity was 98.21% and diagnostic accuracy was 89.5%. In almost every instance, the time required for detection of the growth was earlier by lysis centrifugation method, which was statistically significant. Contamination by lysis centrifugation was minimal, while that by conventional method was high. Time to growth by the lysis centrifugation method was highly significant (P value 0.000) as compared to time to growth by the conventional blood culture method. For the diagnosis of sepsis, combination of the lysis centrifugation method and the conventional blood culture method with trypticase soy broth or biphasic media is advocable, in order to achieve faster recovery and a better yield of microorganisms.

Rotor-dynamic design aspects for a variable frequency drive based high speed cryogenic centrifugal pump in fusion devices

International Nuclear Information System (INIS)

Das, Jotirmoy; Vaghela, Hitensinh; Bhattacharya, Ritendra; Patel, Pratik; Shukla, Vinit; Shah, Nitin; Sarkar, Biswanath

2015-01-01

Superconducting magnets of large size are inevitable for fusion devices due to high magnetic field requirements. Forced flow cooling of the superconducting magnets with high mass flowrate of the order ∼3 kg/s is required to keep superconducting magnets within its safe operational boundaries during various plasma scenarios. This important requirement can be efficiently fulfilled by employing high capacity and high efficiency cryogenic centrifugal pumps. The efficiency > 70% will ensure overall lower heat load to the cryoplant. Thermo-hydraulic design of cryogenic centrifugal pump revealed that to achieve the operational regime with high efficiency, the speed should be ∼ 10,000 revolutions per minute. In this regard, the rotor-dynamic design aspect is quite critical from the operational stability point of view. The rotor shaft design of the cryogenic pump is primarily an outcome of optimization between thermal heat-in leak at cryogenic temperature level from ambient, cryogenic fluid impedance and designed rotation speed of the impeller wheel. The paper describes the basic design related to critical speed of the rotor shaft, rotor whirl and system instability prediction to explore the ideal operational range of the pump from the system stability point of view. In the rotor-dynamic analysis, the paper also describes the Campbell plots to ensure that the pump is not disturbed by any of the critical speeds, especially while operating near the nominal and enhanced operating modes. (author)

Power maximization of an asynchronous wind turbine with a variable speed feeding a centrifugal pump

International Nuclear Information System (INIS)

Ouchbel, T.; Zouggar, S.; Elhafyani, M.L.; Seddik, M.; Oukili, M.; Aziz, A.; Kadda, F.Z.

2014-01-01

Highlights: • The pumping system studied contain a WT, a SEIG, an IM and a CP. • The system must ensure the water pumping in optimum conditions despite the wind speed. • A steady state study and a practical testing are performed to resolve the control law. • A MPPT is proposed on the basis of static converter SVC. - Abstract: This article focuses on the study of a pumping system compound of a wind turbine, a self-excited induction generator (SEIG), an induction motor (IM), and a centrifugal pump (CP), which aims to ensure the water pumping in optimum conditions regardless the wind speed. As a first step, a study in the steady and dynamic state to determine the control law is examined. As a second step, and so as to achieve a maximum energy flow we have proposed a Maximum Power Point Tracking (MPPT) algorithm based on a static converter SVC. As a final step, experimental and simulation results are discussed to show the reliability of the system proposed

Inhibition of pneumococcal autolysis in lysis-centrifugation blood culture.

OpenAIRE

Lehtonen, O P

1986-01-01

The recovery of Streptococcus pneumoniae from the Isolator lysis-centrifugation blood culture has been low in many studies. The poor survival of pneumococci was not due to toxicity of the Isolator medium but to autolysis before plating. This autolysis was completely inhibited by adding 10 mM phosphorylcholine to the Isolator medium.

Blood culture bottles are superior to lysis-centrifugation tubes for bacteriological diagnosis of spontaneous bacterial peritonitis.

OpenAIRE

Siersema, P D; de Marie, S; van Zeijl, J H; Bac, D J; Wilson, J H

1992-01-01

The conventional method of ascitic fluid culturing was compared with the bedside inoculation of ascites into blood culture bottles and into lysis-centrifugation tubes. The conventional culture method was compared with the blood culture bottle method in 31 episodes of spontaneous bacterial peritonitis (SBP). Cultures were positive with the conventional culture method in 11 (35%) episodes and with the blood culture bottle method in 26 (84%) episodes (P less than 0.001). The lysis-centrifugation...

Numerical Research on Hydraulically Generated Vibration and Noise of a Centrifugal Pump Volute with Impeller Outlet Width Variation

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Houlin Liu

2014-01-01

Full Text Available The impeller outlet width of centrifugal pumps is of significant importance for numbers of effects. In the paper, these effects including the performance, pressure pulsations, hydraulically generated vibration, and noise level are investigated. For the purpose, two approaches were used to predict the vibration and sound radiation of the volute under fluid excitation force. One approach is the combined CFD/FEM analysis for structure vibration, and then the structure response obtained from the FEM analysis is treated as the boundary condition for BEM analysis for sound radiation. The other is the combined CFD/FEM/BEM coupling method. Before the numerical methods were used, the simulation results were validated by the vibration acceleration of the monitoring points on the volute. The vibration and noise were analyzed and compared at three flow conditions. The analysis of the results shows that the influences of the sound pressure of centrifugal pumps on the structure appear insignificant. The relative outlet width b2* at nq(SI = 26.7 in this paper should be less than 0.06, based on an overall consideration of the pump characteristics, pressure pulsations, vibration and noise level.

Centrifuge apparatus

Science.gov (United States)

Sartory, Walter K.; Eveleigh, John W.

1976-01-01

A method and apparatus for operating a continuous flow blood separation centrifuge are provided. The hematocrit of the entrant whole blood is continuously maintained at an optimum constant value by the addition of plasma to the entrant blood. The hematocrit of the separated red cells is monitored to indicate the degree of separation taking place, thereby providing a basis for regulating the flow through the centrifuge.

Numerical simulation and performance prediction in multi-stage submersible centrifugal pump

International Nuclear Information System (INIS)

Wang, W J; Li, G D; Wang, Y; Cui, Y R; Yin, G; Peng, S

2013-01-01

In order to study the inner flow field of multi-stage submersible centrifugal pump, the model named QD3-60/4-1.1 was selected. Steady turbulence characteristics of impellers, diffusers and return channel were calculated by Fluent software, the SIMPLEC algorithm and RNG κ-ε turbulence model with sliding mesh technology. Then, the distributions of pressure, velocity and Turbulence kinetic energy was obtained and the distributions of velocity field of a channel were analysed. The results show that the static pressure in impeller is increasing with the increasing of radius. The circumferential component of relative velocity is in the opposite direction of impeller rotating. At the same radius, the component value of pressure surface is larger than suction surface. With the increasing of flow rate, absolute velocity and relative velocity flow angle are becoming small, in opposite of the relative velocity and absolute velocity flow angle. The high turbulent zone of impeller is located in the gap of impellers and diffusers. Flow similarity and structure similarity of the multi-stage submersible pump are confirmed

Experiments of steady state head and torque of centrifugal pumps in two-phase flow

International Nuclear Information System (INIS)

Minato, Akihiko; Tominaga, Kenji.

1988-01-01

Circulation pump behavior has large effect on coolant discharge flow rate in case of reactor pipe break. Experiment of two-phase pump performance was conducted as a joint study of Japanese BWR user utilities and makers. Two-phase head and torque of three centrifugal pumps in high temperature and high pressure (around 6 MPa) steam/water were measured. Head was decreased from single-phase characteristics when gas was mixed in liquid flow in condition with normal flow and normal rotation directions. When flow rate was large enough, two-phase head was about the same as single-phase one in reversal flow conditions. Two-phase head was smoothly increased as flowing steam volumetic concentration increased when flow rate was small and flow direction was reversal. Changes of torque with gas concentration were correspondent to those of head. This suggested that changes of interaction between flow and impellers due to phase slip effected on torque which caused head differences between single- and two-phase flows. Dependence of dimensionless head and torque of three test pumps on steam concentration were almost the same as each other. (author)

On the inverse problem of blade design for centrifugal pumps and fans

Science.gov (United States)

Kruyt, N. P.; Westra, R. W.

2014-06-01

The inverse problem of blade design for centrifugal pumps and fans has been studied. The solution to this problem provides the geometry of rotor blades that realize specified performance characteristics, together with the corresponding flow field. Here a three-dimensional solution method is described in which the so-called meridional geometry is fixed and the distribution of the azimuthal angle at the three-dimensional blade surface is determined for blades of infinitesimal thickness. The developed formulation is based on potential-flow theory. Besides the blade impermeability condition at the pressure and suction side of the blades, an additional boundary condition at the blade surface is required in order to fix the unknown blade geometry. For this purpose the mean-swirl distribution is employed. The iterative numerical method is based on a three-dimensional finite element method approach in which the flow equations are solved on the domain determined by the latest estimate of the blade geometry, with the mean-swirl distribution boundary condition at the blade surface being enforced. The blade impermeability boundary condition is then used to find an improved estimate of the blade geometry. The robustness of the method is increased by specific techniques, such as spanwise-coupled solution of the discretized impermeability condition and the use of under-relaxation in adjusting the estimates of the blade geometry. Various examples are shown that demonstrate the effectiveness and robustness of the method in finding a solution for the blade geometry of different types of centrifugal pumps and fans. The influence of the employed mean-swirl distribution on the performance characteristics is also investigated.

On the inverse problem of blade design for centrifugal pumps and fans

International Nuclear Information System (INIS)

Kruyt, N P; Westra, R W

2014-01-01

The inverse problem of blade design for centrifugal pumps and fans has been studied. The solution to this problem provides the geometry of rotor blades that realize specified performance characteristics, together with the corresponding flow field. Here a three-dimensional solution method is described in which the so-called meridional geometry is fixed and the distribution of the azimuthal angle at the three-dimensional blade surface is determined for blades of infinitesimal thickness. The developed formulation is based on potential-flow theory. Besides the blade impermeability condition at the pressure and suction side of the blades, an additional boundary condition at the blade surface is required in order to fix the unknown blade geometry. For this purpose the mean-swirl distribution is employed. The iterative numerical method is based on a three-dimensional finite element method approach in which the flow equations are solved on the domain determined by the latest estimate of the blade geometry, with the mean-swirl distribution boundary condition at the blade surface being enforced. The blade impermeability boundary condition is then used to find an improved estimate of the blade geometry. The robustness of the method is increased by specific techniques, such as spanwise-coupled solution of the discretized impermeability condition and the use of under-relaxation in adjusting the estimates of the blade geometry. Various examples are shown that demonstrate the effectiveness and robustness of the method in finding a solution for the blade geometry of different types of centrifugal pumps and fans. The influence of the employed mean-swirl distribution on the performance characteristics is also investigated. (paper)

Ultrafast X-ray tomography for two-phase flow analysis in centrifugal pumps

International Nuclear Information System (INIS)

Schaefer, Thomas; Hampel, Uwe; Technische Univ. Dresden

2017-01-01

The unsteady behavior of gas-liquid two-phase flow in a centrifugal pump impeller has been visualized, using ultrafast X-ray tomography. Based on the reconstructed tomographic images an evaluation and detailed analysis of the flow conditions has been done. Here, the high temporal resolution of the tomographic images offered the opportunity to get a deep insight into the flow to perform a detailed description of the transient gas-liquid phase distribution inside the impeller. Significant properties of the occurring two-phase flow and characteristic flow patterns have been disclosed. Furthermore, the effects of different air entrainment conditions have been investigated and typical phase distributions inside the impeller have been shown.

Ultrafast X-ray tomography for two-phase flow analysis in centrifugal pumps

Energy Technology Data Exchange (ETDEWEB)

Schaefer, Thomas [Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany). Inst. of Fluid Dynamics; Hampel, Uwe [Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany). Inst. of Fluid Dynamics; Technische Univ. Dresden (Germany). AREVA Endowed Chair of Imaging Techniques in Energy and Process Engineering

2017-07-15

The unsteady behavior of gas-liquid two-phase flow in a centrifugal pump impeller has been visualized, using ultrafast X-ray tomography. Based on the reconstructed tomographic images an evaluation and detailed analysis of the flow conditions has been done. Here, the high temporal resolution of the tomographic images offered the opportunity to get a deep insight into the flow to perform a detailed description of the transient gas-liquid phase distribution inside the impeller. Significant properties of the occurring two-phase flow and characteristic flow patterns have been disclosed. Furthermore, the effects of different air entrainment conditions have been investigated and typical phase distributions inside the impeller have been shown.

Centrifugation after irradiation of red blood cells does not accelerate haemolysis.

Science.gov (United States)

Weiss, Dominik R; Goehring, Jasmin; Weisbach, Volker; Strasser, Erwin F; Ringwald, Juergen; Zimmermann, Robert; Eckstein, Reinhold

2011-01-01

For intrauterine transfusion and some other rare indications, irradiation and washing or adjustment to an elevated haematocrit is necessary. No data are currently available indicating whether irradiation of red blood cell concentrates (RBCs) might impair the mechanical stability of erythrocytes during centrifugation leading to elevated haemolysis. Consequently, if irradiation and centrifugation of RBCs is necessary, there is no definitive recommendation about the preferred sequence of steps. We divided 20 RBC units that were not older than 9 days into two subunits. These subunits were prepared to yield irradiated RBCs with an elevated haematocrit, as they are used for intrauterine transfusion. One subunit was centrifuged and then irradiated, the other subunit was irradiated and then centrifuged. The units were evaluated in vitro before preparation and on days 1 and 7. We could not find any difference in the haemolysis rate, extracellular LDH or alpha-HBDH between the two groups of RBCs. This observation indicates that centrifugation after irradiation of RBCs does not accelerate haemolysis. A similar ATP content in the two subunits demonstrated no difference in energy metabolism. The extracellular potassium concentration was significantly lower in the subunits washed after irradiation. There is no difference in the haemolysis caused by centrifugation between irradiated and non-irradiated RBCs. However, it is well known that washing RBCs after irradiation significantly lowers the potassium content. Summarising these two findings leads to the conclusion that it is optimal first to irradiate and then to wash RBCs.

Evaluation of enrichment by centrifugal separation: the future of the centrifugal-separation method

International Nuclear Information System (INIS)

Kanagawa, A.

A gas centrifuge plant for uranium enrichment is considered from the point of view of economic competition with other methods. Characteristics of the method are presented including: energy efficiency, the cascade, the separation coefficient, the equilibrium separation process, and capability as centrifugal pump. The structure of an individual gas centrifuge separator is described including the rotating cylinder, mechanisms for gas injection and extraction, mechanisms for counter-streaming of gas, the axle holder mechanism, the gas sealing mechanism, and the driving mechanism. (U.S.)

Two-Dimensional Computational Flow Analysis and Frictional Characteristics Model for Red Blood Cell under Inclined Centrifuge Microscopy

Science.gov (United States)

Funamoto, Kenichi; Hayase, Toshiyuki; Shirai, Atsushi

Simplified two-dimensional flow analysis is performed in order to simulate frictional characteristics measurement of red blood cells moving on a glass plate in a medium with an inclined centrifuge microscope. Computation under various conditions reveals the influences of parameters on lift, drag, and moment acting on a red blood cell. Among these forces, lift appears only when the cell is longitudinally asymmetric. By considering the balance of forces, the frictional characteristics of the red blood cell are modeled as the sum of Coulomb friction and viscous drag. The model describes the possibility that the red blood cell deforms to expand in the front side in response to the inclined centrifugal force. When velocity exceeds some critical value, the lift overcomes the normal centrifugal force component, and the thickness of the plasma layer between the cell and the glass plate increases from the initial value of the plasma protein thickness.

Combined short-arm centrifuge and aerobic exercise training improves cardiovascular function and physical working capacity in humans.

Science.gov (United States)

Yang, Chang-Bin; Zhang, Shu; Zhang, Yu; Wang, Bing; Yao, Yong-Jie; Wang, Yong-Chun; Wu, Yan-Hong; Liang, Wen-Bin; Sun, Xi-Qing

2010-12-01

Musculoskeletal and cardiovascular deconditioning occurring in long-term spaceflight gives rise to the needs to develop new strategies to counteract these adverse effects. Short-arm centrifuge combined with ergometer has been proposed as a strategy to counteract adverse effects of microgravity. This study sought to investigate whether the combination of short-arm centrifuge and aerobic exercise training have advantages over short-arm centrifuge or aerobic exercise training alone. One week training was conducted by 24 healthy men. They were randomly divided into 3 groups: (1) short-arm centrifuge training, (2) aerobic exercise training, 40 W, and (3) combined short-arm centrifuge and aerobic exercise training. Before and after training, the cardiac pump function represented by stroke volume, cardiac output, left ventricular ejection time, and total peripheral resistance was evaluated. Variability of heart rate and systolic blood pressure were determined by spectral analysis. Physical working capacity was surveyed by near maximal physical working capacity test. The 1-week combined short-arm centrifuge and aerobic exercise training remarkably ameliorated the cardiac pump function and enhanced vasomotor sympathetic nerve modulation and improved physical working capacity by 10.9% (Pcentrifuge nor the aerobic exercise group showed improvements in these functions. These results demonstrate that combined short-arm centrifuge and aerobic exercise training has advantages over short-arm centrifuge or aerobic exercise training alone in influencing several physiologically important cardiovascular functions in humans. The combination of short-arm centrifuge and aerobic exercise offers a promising countermeasure to microgravity.

CFD simulation of centrifugal cells washers.

Science.gov (United States)

Kellet, Beth E; Binbing, Han; Dandy, David S; Wickramasinghe, S Ranil

2004-01-01

The feasibility of using computational fluid dynamics to guide the design of better centrifuges for processing shed blood is explored here. The velocity field and the rate of protein removal from the shed blood have been studied. The results indicate that computational fluid dynamics could help screen preliminary centrifuge bowl designs thus reducing the number of initial experimental tests required when developing new centrifuge bowls. Though the focus of this work is on washing shed blood the methods developed here are applicable to the design of centrifuge bowls for other blood processing applications.

An Experimental Study on the Radiation Noise Characteristics of a Centrifugal Pump with Various Working Conditions

Directory of Open Access Journals (Sweden)

Chang Guo

2017-12-01

Full Text Available To investigate the radiation noise characteristics of a centrifugal pump under various working conditions, a noise measurement system is established; afterwards, the distribution of different points and intervals, as well as the overall level of noise, are studied. The total sound pressure level distribution for different points manifests the dipole and asymmetric directivity characteristics. Additionally, the acoustic energy is introduced to compare the noise of different intervals to reveal the asymmetric characteristics, and it is found that variation in working conditions has little impact on the acoustic energy distribution, and the ratio of the acoustic energy in the direction facing the tongue, as well as that in the direction against the tongue, to total acoustic energy fluctuate around 0.410 and 0.160, respectively, under various working conditions. Also, the A-weighted average sound pressure level (LpA is applied to describe the overall level of noise, and LpA increases gradually with the growth of rotational speed, but the growth slope decreases. While in the operation of throttling regulation, LpA shows the trend that first increases, then remains stable, and increases again with the growth of flow rate. This study could provide guidance for optimizing the operating conditions and noise control of centrifugal pumps.

Influence of Velocity Curves Unevenness on the Centrifugal Pump Head

Directory of Open Access Journals (Sweden)

V. A. Cheryomushkin

2017-01-01

Full Text Available A formula of the theoretical head, which gives the value of the impeller in terms of its geometrical parameters, is used to calculate the pump head at the stage of theoretical design. One of the main assumptions in this case is a strip theory, which does not take into consideration the unevenness of curves of the meridional and circumferential velocity components at the impeller outlet of a centrifugal pump. The article studies this influence. Describes a mathematical model for theoretical and numerical calculations. Shows the figures of the flow part under study and of the computational grid. For complete formalization of the problem the meshing models and boundary conditions are shown. As the boundary conditions, full pump-inlet head into the flow part and velocity at the outlet were used. Then, there are the graphs to compare the results of theoretical and numerical calculation and the error is shown. For comparison, a value of the theoretical head was multiplied by the efficiency, which was defined by computer simulation. A designing process of the flow part was iterative, so the comparison was carried out for all iterations. It should be noted that correction for the finite number of blades is also assumption. To determine a degree of the errors impact because of this correction, an average value of the circumferential component of the fluid velocity at the impeller outlet was calculated by two above methods followed by their comparison. It was shown that this impact is negligible, i.e. correction provides a sufficiently accurate value. In conclusion, the paper explains the possible reasons for inaccuracies in theoretical determination of the head, as well as the option to eliminate this inaccuracy, thereby reducing the time required for defining the basic parameters of the flow part. To illustrate the nature of fluid flow, for the last iteration are given the fields of the pressure distribution and the velocity vector in the equatorial

Centrifugal pump assembly for use in nuclear reactor plants or the like

International Nuclear Information System (INIS)

Honold, E.; Ruepp, M.

1975-01-01

A description is given of a vertical centrifugal pump assembly for use as a primary recirculating pump in a nuclear reactor plant which has an uppermost shaft which is driven by a motor, a lowermost shaft which drives the impeller of the pump, and an intermediate shaft which is movable axially between the uppermost and lowermost shafts and carries a housing for radial and/or thrust bearings. A rigid coupling between the lowermost shaft and the intermediate shaft is disengaged when the intermediate shaft is lifted to thereby afford access to certain parts of the lowermost shaft. The uppermost shaft can drive the intermediate shaft through the medium of a flexible coupling having coupling elements mounted on the lower end of the uppermost shaft and the upper end of the intermediate shaft, and a distancing sleeve whose internal threads are in permanent mesh with external threads of the two coupling elements. A shroud which surrounds the flexible coupling has a maximum-diameter tubular section rigid with the housing for the bearings, a minimum-diameter tubular section rigid with but detachable from the casing of the motor, and a median tubular section which penetrates into the maximum-diameter section when the intermediate shaft is lifted. When the minimum-diameter section is detached from the casing of the motor, it can be slid, together with the intermediate section, into the maximum-diameter section to thereby afford access to the flexible coupling. The rigid coupling has two coaxial coupling elements which are mounted at the upper end of the pump shaft and the lower end of the intermediate shaft and may have teeth which mate when the intermediate shaft assumes its lower end position in which it can drive the pump

ICDE project report on collection and analysis of common-cause failures of centrifugal pumps

International Nuclear Information System (INIS)

2000-01-01

Several member countries of OECD/NEA decided to establish the International Common-Cause Failure Data Exchange (ICDE) Project to encourage multilateral co-operation in the collection and analysis of data relating to Common-Cause Failure (CCF) events. The project was initiated in August 1994 in Sweden and was discussed at meetings in both Sweden and France in 1995. A coding benchmark exercise was defined which was evaluated at meetings held in Germany and in the US in 1996. Subsequently, the exchange of centrifugal pump data was defined; the first phase of this exchange was evaluated at meetings in Switzerland and in France in 1997. The objectives of the ICDE Project are: - to collect and analyse CCF events in the long term so as to better understand such events, their causes, and their prevention, - to generate qualitative insights into the root causes of CCF events which can then be used to derive approaches or mechanisms for their prevention or for mitigating their consequences, - to establish a mechanism for the efficient feedback of experience gained on CCF phenomena, including the development of defences against their occurrence, such as indicators for risk based inspections. The ICDE Project is envisaged as including all possible events of interest, comprising complete, partial and incipient CCF events, called 'ICDE events' in the following. The Project covers the key components of the main safety systems, like centrifugal pumps, diesel generators, motor operated valves, power operated relief valves, safety relief valves, check valves, RPS circuit breakers, batteries and transmitters. Data are collected in an MS ACCESS based databank implemented and maintained at ES-Konsult, Sweden, by NEA appointed clearinghouse. The databank is regularly updated. The clearinghouse and the project group operate it. In the modelling of common-cause failures in systems consisting of several redundant components, two kinds of events are distinguished: a) Unavailability of a

Detection of pump degradation

International Nuclear Information System (INIS)

Casada, D.A.

1994-01-01

There are a variety of stressors that can affect the operation of centrifugal pumps. These can generally be classified as: Mechanical; Hydraulic; Tribological; Chemical; and Other (including those associated with the pump driver). Although these general stressors are active in essentially all centrifugal pumps, the stressor level and the extent of wear and degradation can vary greatly. Parameters that affect the extent of stressor activity are manifold. In order to assure the long-term operational readiness of a pump, it is important to both understand the nature and magnitude of the specific degradation mechanisms and to monitor the performance of the pump

Vertical axis wind turbine power regulation through centrifugally pumped lift spoiling

Science.gov (United States)

Klimas, P. C.; Sladky, J. F., Jr.

This paper describes an approach for lowering the rated windspeeds of Darrieus-type vertical axis wind turbines (VAWTs) whose blades are hollow aluminum extrusions. The blades, which when rotating act as centrifugal pumps, are fitted with a series of small perforations distributed along a portion of the blades' span. By valving the ends of the hollow blades, flow into the blade ends and out of the perforations may be controlled. This flow can induce premature aerodynamic stall on the blade elements, thereby reducing both the rated power of the turbine and its cost-of-energy. The concept has been proven on the Sandia National Laboratories 5-m diameter research VAWT and force balance and flow visualization wind tunnel tests have been conducted using a blade section designed for the VAWT application.

Acute hydrodynamic damage induced by SPLITT fractionation and centrifugation in red blood cells.

Science.gov (United States)

Urbina, Adriana; Godoy-Silva, Ruben; Hoyos, Mauricio; Camacho, Marcela

2016-05-01

Though blood bank processing traditionally employs centrifugation, new separation techniques may be appealing for large scale processes. Split-flow fractionation (SPLITT) is a family of techniques that separates in absence of labelling and uses very low flow rates and force fields, and is therefore expected to minimize cell damage. However, the hydrodynamic stress and possible consequent damaging effects of SPLITT fractionation have not been yet examined. The aim of this study was to investigate the hydrodynamic damage of SPLITT fractionation to human red blood cells, and to compare these effects with those induced by centrifugation. Peripheral whole blood samples were collected from healthy volunteers. Samples were diluted in a buffered saline solution, and were exposed to SPLITT fractionation (flow rates 1-10 ml/min) or centrifugation (100-1500 g) for 10 min. Cell viability, shape, diameter, mean corpuscular hemoglobin, and membrane potential were measured. Under the operating conditions employed, both SPLITT and centrifugation maintained cell viability above 98%, but resulted in significant sublethal damage, including echinocyte formation, decreased cell diameter, decreased mean corpuscular hemoglobin, and membrane hyperpolarization which was inhibited by EGTA. Wall shear stress and maximum energy dissipation rate showed significant correlation with lethal and sublethal damage. Our data do not support the assumption that SPLITT fractionation induces very low shear stress and is innocuous to cell function. Some changes in SPLITT channel design are suggested to minimize cell damage. Measurement of membrane potential and cell diameter could provide a new, reliable and convenient basis for evaluation of hydrodynamic effects on different cell models, allowing identification of optimal operating conditions on different scales. Copyright © 2016 Elsevier B.V. All rights reserved.

Maintenance strategy based on reliability functions for an oil centrifugal pump

Directory of Open Access Journals (Sweden)

Denis Carlos Mengue

2013-06-01

Full Text Available The purpose of this article was to define the most appropriate maintenance strategy for a centrifugal pump (preventive, predictive, corrective or emergency, based on reliability calculation. The research method was the quantitative modeling, applied in a petroleum plant. The study may contribute to the development of a strategic model for the management of the industrial plant maintenance. In the company's information system, records of eleven years have been gathered on times between failures and times for repair of the equipment. These times were modeled by probability distributions. From the results obtained were calculated Reliability and Maintainability functions R(t and M(t. By combining their expected values (MTBF and MTTR, Av availability was calculated. The figures for MTBF, MTTR and Av were respectively 3,936 hours, 133 hours and 96.73%. The most likely shape factor of the Weibull distribution which modeled the time between failures was 0.69. So, it was possible to affirm that the pump is in the infant mortality phase. The theoretical framework of RCM indicated corrective  maintenance as the strategy for the item. This strategy aims to eliminate the defects of equipment design, reinforce items that usually break and remove the causes of the failures.

Flow measurements in a model centrifugal pump by 3-D PIV

International Nuclear Information System (INIS)

Yang, H; Xu, H R; Liu, C

2012-01-01

PIV (Particle Image Velocimetry), as an non-intrusive flow measurements technology, is widely used to investigate the flow fields in many areas. 3-D (three Dimensional) PIV has seldom been used to measure flow field in rotational impeller of centrifugal pump due to the difficulty of calibration in samll space. In this article, a specially manufactured water tank was used to perform the calibration for 3-D PIV measurement. The instantaneous absolute velocity in one impeller passage was obtained by merging of three sub zones and the relative velocity was acquired by velocity decomposition. The result shows that, when the pump runs at the condition of design flow rate, the radial component velocity W r appears a concave distribution except the condition of R=45 mm. With the increase of radius, the circumference location of the minimum radial component velocity W r moves from the pressure side to the suction side. At the same time, the tangential component velocity W θ on the suction side decreases gradually with the increase of radius, while the component on the pressure side increases gradually. The secondary flow in different radius section has also been shown. At last, the error of PIV measurements was analyzed, which shows that the test results are accurate and the measured data is reliable.

Centrifugation-free washing: A novel approach for removing immunoglobulin A from stored red blood cells.

Science.gov (United States)

Vörös, Eszter; Piety, Nathaniel Z; Strachan, Briony C; Lu, Madeleine; Shevkoplyas, Sergey S

2018-08-01

Washed red blood cells (RBCs) are indicated for immunoglobulin A (IgA) deficient recipients. Centrifugation-based cell processors commonly used by hospital blood banks cannot consistently reduce IgA below the recommended levels, hence double washing is frequently required. Here, we describe a prototype of a simple, portable, disposable system capable of washing stored RBCs without centrifugation, while reducing IgA below 0.05 mg/dL in a single run. Samples from RBC units (n = 8, leukoreduced, 4-6 weeks storage duration) were diluted with normal saline to a hematocrit of 10%, and then washed using either the prototype washing system, or via conventional centrifugation. The efficiency of the two washing methods was quantified and compared by measuring several key in vitro quality metrics. The prototype of the washing system was able to process stored RBCs at a rate of 300 mL/hour, producing a suspension of washed RBCs with 43 ± 3% hematocrit and 86 ± 7% cell recovery. Overall, the two washing methods performed similarly for most measured parameters, lowering the concentration of free hemoglobin by >4-fold and total free protein by >10-fold. Importantly, the new washing system reduced the IgA level to 0.02 ± 0.01 mg/mL, a concentration 5-fold lower than that produced by conventional centrifugation. This proof-of-concept study showed that centrifugation may be unnecessary for washing stored RBCs. A simple, disposable, centrifugation-free washing system could be particularly useful in smaller medical facilities and resource limited settings that may lack access to centrifugation-based cell processors. © 2017 Wiley Periodicals, Inc.

Comparison of the lysis-centrifugation and agitated biphasic blood culture systems for detection of fungemia.

Science.gov (United States)

Murray, P R

1991-01-01

Although the detection of fungemia has been improved by the use of vented or biphasic blood culture bottles, the best recovery and earliest detection have been reported in the Isolator lysis-centrifugation system. It was recently demonstrated that improved detection of both bacteria and fungi was accomplished by mechanically agitating blood culture bottles for the first 24 h of incubation. In this study the detection of fungemia by use of the Isolator system was compared with that of an agitated biphasic system. A total of 182 fungi were isolated from blood specimens inoculated into both culture systems. No difference in the overall recovery of fungi or individual species of yeasts was observed between the two systems. However, all seven isolates of Histoplasma capsulatum were recovered in the Isolator system only. The time required to detect fungemia with each of the two systems was also compared. No statistically significant difference was observed. From the data collected during this 18-month study, it can be concluded that the overall recovery and time of detection of yeasts are equivalent in the lysis-centrifugation system and the agitated biphasic blood culture system. The lysis-centrifugation system is still superior for the detection of filamentous fungi such as H. capsulatum. PMID:1993772

Impact of Ficoll density gradient centrifugation on major and trace element concentrations in erythrocytes and blood plasma.

Science.gov (United States)

Lu, Ying; Ahmed, Sultan; Harari, Florencia; Vahter, Marie

2015-01-01

Ficoll density gradient centrifugation is widely used to separate cellular components of human blood. We evaluated the suitability to use erythrocytes and blood plasma obtained from Ficoll centrifugation for assessment of elemental concentrations. We determined 22 elements (from Li to U) in erythrocytes and blood plasma separated by direct or Ficoll density gradient centrifugation, using inductively coupled plasma mass spectrometry. Compared with erythrocytes and blood plasma separated by direct centrifugation, those separated by Ficoll had highly elevated iodine and Ba concentration, due to the contamination from the Ficoll-Paque medium, and about twice as high concentrations of Sr and Mo in erythrocytes. On the other hand, the concentrations of Ca in erythrocytes and plasma were markedly reduced by the Ficoll separation, to some extent also Li, Co, Cu, and U. The reduced concentrations were probably due to EDTA, a chelator present in the Ficoll medium. Arsenic concentrations seemed to be lowered by Ficoll, probably in a species-specific manner. The concentrations of Mg, P, S, K, Fe, Zn, Se, Rb, and Cs were not affected in the erythrocytes, but decreased in plasma. Concentrations of Mn, Cd, and Pb were not affected in erythrocytes, but in plasma affected by EDTA and/or pre-analytical contamination. Ficoll separation changed the concentrations of Li, Ca, Co, Cu, As, Mo, I, Ba, and U in erythrocytes and blood plasma, Sr in erythrocytes, and Mg, P, S, K, Fe, Zn, Se, Rb and Cs in blood plasma, to an extent that will invalidate evaluation of deficiencies or excess intakes. Copyright © 2014 Elsevier GmbH. All rights reserved.

Pump integrated closed loop control. The intelligent actuator pump - state of the art and perspectives; Pumpenintegrierte Prozessregelung. Der intelligente Aktor Pumpe - Stand und Moeglichkeiten

Energy Technology Data Exchange (ETDEWEB)

Paulus, Thomas; Schullerer, Joachim; Oesterle, Manfred [KSB AG, Frankenthal (Germany)

2009-07-01

In many areas of industrial automation, centrifugal pumps and systems of centrifugal pumps are important actuators of a process und therefore a fundamental part of the entire plant. In contrary to the controlled valves, located behind the pump in the pipework system, the functions of the intelligent actuator pump or system of pumps are rarely used and noticed. With regard to the reduction of life cycle costs of the asset pump, pump integrated closed loop control of the fluid transport task has advantages over central closed loop control e.g. in a process control system. This article contains a survey of the intelligent actuator pump, its structure and functions with regard to the solution of the fluid transport task and according pump integrated closed loop control. (orig.)

Assessment of a turbulence model for numerical predictions of sheet-cavitating flows in centrifugal pumps

Energy Technology Data Exchange (ETDEWEB)

Liu, Houlin; Wang, Yong; Liu, Dongxi; Yuan, Shouqi; Wang, Jian [Jiangsu University, Zhenjiang (China)

2013-09-15

Various approaches have been developed for numerical predictions of unsteady cavitating turbulent flows. To verify the influence of a turbulence model on the simulation of unsteady attached sheet-cavitating flows in centrifugal pumps, two modified RNG k-ε models (DCM and FBM) are implemented in ANSYS-CFX 13.0 by second development technology, so as to compare three widespread turbulence models in the same platform. The simulation has been executed and compared to experimental results for three different flow coefficients. For four operating conditions, qualitative comparisons are carried out between experimental and numerical cavitation patterns, which are visualized by a high-speed camera and depicted as isosurfaces of vapor volume fraction α{sub v} = 0.1, respectively. The comparison results indicate that, for the development of the sheet attached cavities on the suction side of the impeller blades, the numerical results with different turbulence models are very close to each other and overestimate the experiment ones slightly. However, compared to the cavitation performance experimental curves, the numerical results have obvious difference: the prediction precision with the FBM is higher than the other two turbulence models. In addition, the loading distributions around the blade section at midspan are analyzed in detail. The research results suggest that, for numerical prediction of cavitating flows in centrifugal pumps, the turbulence model has little influence on the development of cavitation bubbles, but the advanced turbulence model can significantly improve the prediction precision of head coefficients and critical cavitation numbers.

Development of electric drive for centrifugal mine pumps in Solikamsk Potassium Mine Group Based on Industrial OMRON Controller

Science.gov (United States)

Kostarev, S. N.; Sereda, T. G.; Tatarnikova, N. A.; Kochetova, O. V.

2018-03-01

The electric drive for automation pumping out of filtration waters in the Second Solikamsk Potasssium Mine Group is developed. The emergency situation of flooding of the Mine has been considered in the course of development of the Upper Kama deposits of potash-magnesium salts. The functional scheme of automation of a drive of the pump is developed. The scheme is stipulated with manual and automatic control. To decrease the risk of flooding of mine, it is recommended to establish gauges of both bottom and top level control of a brine and other equipment in the collector of a brine: the gauge of measurementof a level, the gauge of the signal system of a level, the gauge of the pump control, the gauge of the signal system of a level with remote data transmission. For regulation of the charge of sewage, the P-regulator with the executive mechanism is stipulated. The ladder diagram of a pump control is developed to improve the work of centrifugal pumps and to prevent the cases of mines flooding.

Modeling centrifugal cell washers using computational fluid dynamics.

Science.gov (United States)

Kellet, Beth E; Han, Binbing; Dandy, David S; Wickramasinghe, S Ranil

2004-11-01

Reinfusion of shed blood during surgery could avoid the need for blood transfusions. Prior to reinfusion of the red blood cells, the shed blood must be washed in order to remove leukocytes, platelets, and other contaminants. Further, the hematocrit of the washed blood must be increased. The feasibility of using computational fluid dynamics (CFD) to guide the design of better centrifuges for processing shed blood is explored here. The velocity field within a centrifuge bowl and the rate of protein removal from the shed blood has been studied. The results obtained indicate that CFD could help screen preliminary centrifuge bowl designs, thus reducing the number of initial experimental tests required when developing new centrifuge bowls. Although the focus of this work is on washing shed blood, the methods developed here are applicable to the design of centrifuge bowls for other blood-processing applications.

Comparison of dimensionality reduction techniques for the fault diagnosis of mono block centrifugal pump using vibration signals

Directory of Open Access Journals (Sweden)

N.R. Sakthivel

2014-03-01

Full Text Available Bearing fault, Impeller fault, seal fault and cavitation are the main causes of breakdown in a mono block centrifugal pump and hence, the detection and diagnosis of these mechanical faults in a mono block centrifugal pump is very crucial for its reliable operation. Based on a continuous acquisition of signals with a data acquisition system, it is possible to classify the faults. This is achieved by the extraction of features from the measured data and employing data mining approaches to explore the structural information hidden in the signals acquired. In the present study, statistical features derived from the vibration data are used as the features. In order to increase the robustness of the classifier and to reduce the data processing load, dimensionality reduction is necessary. In this paper dimensionality reduction is performed using traditional dimensionality reduction techniques and nonlinear dimensionality reduction techniques. The effectiveness of each dimensionality reduction technique is also verified using visual analysis. The reduced feature set is then classified using a decision tree. The results obtained are compared with those generated by classifiers such as Naïve Bayes, Bayes Net and kNN. The effort is to bring out the better dimensionality reduction technique–classifier combination.

A numerically research on energy loss evaluation in a centrifugal pump system based on local entropy production method

Directory of Open Access Journals (Sweden)

Hou Hucan

2017-01-01

Full Text Available Inspired by wide application of the second law of thermodynamics to flow and heat transfer devices, local entropy production analysis method was creatively introduced into energy assessment system of centrifugal water pump. Based on Reynolds stress turbulent model and energy equation model, the steady numerical simulation of the whole flow passage of one IS centrifugal pump was carried out. The local entropy production terms were calculated by user defined functions, mainly including wall entropy production, turbulent entropy production, and viscous entropy production. The numerical results indicated that the irreversible energy loss calculated by the local entropy production method agreed well with that calculated by the traditional method but with some deviations which were probably caused by high rotatability and high curvature of impeller and volute. The wall entropy production and turbulent entropy production took up large part of the whole entropy production about 48.61% and 47.91%, respectively, which indicated that wall friction and turbulent fluctuation were the major factors in affecting irreversible energy loss. Meanwhile, the entropy production rate distribution was discussed and compared with turbulent kinetic energy dissipation rate distribution, it showed that turbulent entropy production rate increased sharply at the near wall regions and both distributed more uniformly. The blade region in leading edge near suction side, trailing edge and volute tongue were the main regions to generate irreversible exergy loss. This research broadens a completely new view in evaluating energy loss and further optimizes pump using entropy production minimization.

Method and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer

Science.gov (United States)

Burtis, C.A.; Johnson, W.F.; Walker, W.A.

1985-08-05

A rotor and disc assembly for use in a centrifugal fast analyzer. The assembly is designed to process multiple samples of whole blood followed by aliquoting of the resultant serum into precisely measured samples for subsequent chemical analysis. The assembly requires minimal operator involvement with no mechanical pipetting. The system comprises: (1) a whole blood sample disc; (2) a serum sample disc; (3) a sample preparation rotor; and (4) an analytical rotor. The blood sample disc and serum sample disc are designed with a plurality of precision bore capillary tubes arranged in a spoked array. Samples of blood are loaded into the blood sample disc by capillary action and centrifugally discharged into cavities of the sample preparation rotor where separation of serum and solids is accomplished. The serum is loaded into the capillaries of the serum sample disc by capillary action and subsequently centrifugally expelled into cuvettes of the analyticaly rotor for conventional methods. 5 figs.

Method and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer

Science.gov (United States)

Burtis, Carl A.; Johnson, Wayne F.; Walker, William A.

1988-01-01

A rotor and disc assembly for use in a centrifugal fast analyzer. The assembly is designed to process multiple samples of whole blood followed by aliquoting of the resultant serum into precisely measured samples for subsequent chemical analysis. The assembly requires minimal operator involvement with no mechanical pipetting. The system comprises (1) a whole blood sample disc, (2) a serum sample disc, (3) a sample preparation rotor, and (4) an analytical rotor. The blood sample disc and serum sample disc are designed with a plurality of precision bore capillary tubes arranged in a spoked array. Samples of blood are loaded into the blood sample disc in capillary tubes filled by capillary action and centrifugally discharged into cavities of the sample preparation rotor where separation of serum and solids is accomplished. The serum is loaded into the capillaries of the serum sample disc by capillary action and subsequently centrifugally expelled into cuvettes of the analytical rotor for analysis by conventional methods.

PIV pictures of stream field predict haemolysis index of centrifugal pump with streamlined impeller.

Science.gov (United States)

Qian, K X; Feng, Z G; Ru, W M; Zeng, P; Yuan, H Y

2007-01-01

Previously it has been found by pump haemolysis testing that the flow rate has a remarkable effect on index of haemolysis (IH), while pressure head does not affect IH. Recent investigation with particle image velocimetry (PIV) technology has demonstrated that IH is directly related to the flow pattern of stream field in impeller vane channels. PIV is a visible approach showing the real flow status in the pump. The different positions of a tracer particle in two PIV pictures taken at 20 micros intervals decide the velocity value and direction. The velocity vectors of many particles draw the flow pattern of the stream field. The same pictures are taken at 2, 4 and 6 l min(-1) flow rates while the pressure head is kept unchanged at 100 mmHg; then the pictures are taken at 4 l min(-1) flow with different pressure heads of 80, 100 and 120 mmHg. Results reveal that the flow rate of 4 l min(-1) (IH = 0.030) has the best stream field, and neither turbulence nor separation can be seen. In other flow rates (IH: 0.048 - 0.082), there is obviously second flow. Meanwhile, no significant difference can be seen among the PIV pictures of different pressure heads pumped, which agrees with the results of haemolysis testing showing that pressure has no effect on pump haemolysis. It may be concluded that the haemolysis property of a centrifugal pump can be assessed approximately by PIV pictures, which are much easier to take than haemolysis tests.

Hydrostatic radial bearing of centrifugal pump

International Nuclear Information System (INIS)

Skalicky, A.

1976-01-01

A hydrostatic radial pump is described characterized by the fact that part of the medium off-taken from delivery is used as a lubricating medium. Two additional bodies are placed alongside a hydrostatic bearing with coils in between them and the pump shaft; the coils have an opposite pitch. The feed channel for the hydrostatic bearing pocket is linked to delivery. The coil outlets are connected to the pump suction unit. Two rotating coils placed alongside the hydrostatic bearing will considerably simplify the communication channel design and reduce the dependence on the pump shaft deflections. The addition of another rotating coil in the close vicinity of the pump shaft or directly on the shaft further increases the efficiency. The bearing can be used in designing vertical circulating pumps for the cooling circuits of nuclear reactors. (J.B.)

Dynamic characteristics and mechatronics model for maglev blood pump

Science.gov (United States)

Sun, Kun; Chen, Chen

2017-01-01

Magnetic bearing system(MBs) has been developed in the new-generation blood pump due to its low power consumption, low blood trauma and high durability. However, MBs for a blood pump were almost influenced by a series of factors such as hemodynamics, rotation speeds and actuator response in working fluids, compared with those applied in other industrial fields. In this study, the dynamic characteristics of MBs in fluid environments, including the influence of the pumping fluid and rotation of the impeller on the radial dynamic model were investigated by measuring the frequency response to sinusoidal excitation upon coils, and the response of radial displacement during a raise in the speed. The excitation tests were conducted under conditions in which the blood pump was levitated in air and water and with or without rotation. The experimental and simulated results indicate that rotations of the impeller affected the characteristics of MBs in water apparently, and the vibration in water was decreased, compared with that in air due to the hydraulic force. During the start-up and rotation, the actuator failed to operate fully and timely, and the voltage supplied can be chosen under the consideration of the rotor displacement and consumption.

Centrifugation: an important pre-analytic procedure that influences plasma microRNA quantification during blood processing.

Science.gov (United States)

Zheng, Xiao-Hui; Cui, Cui; Zhou, Xin-Xi; Zeng, Yi-Xin; Jia, Wei-Hua

2013-12-01

Circulating microRNAs are robustly present in plasma or serum and have become a research focus as biomarkers for tumor diagnosis and prognosis. Centrifugation is a necessary procedure for obtaining high-quality blood supernatant. Herein, we investigated one-step and two-step centrifugations, two centrifugal methods routinely used in microRNA study, to explore their effects on plasma microRNA quantification. The microRNAs obtained from one-step and two-step centrifugations were quantified by microarray and TaqMan-based real-time quantitative polymerase chain reaction (Q-PCR). Dynamic light scattering was performed to explore the difference underlying the two centrifugal methods. The results from the microarray containing 1,347 microRNAs showed that the signal detection rate was greatly decreased in the plasma sample prepared by two-step centrifugation. More importantly, the microRNAs missing in this plasma sample could be recovered and detected in the precipitate generated from the second centrifugation. Consistent with the results from microarray, a marked decrease of three representative microRNAs in two-step centrifugal plasma was validated by Q-PCR. According to the size distribution of all nanoparticles in plasma, there were fewer nanoparticles with size >1,000 nm in two-step centrifugal plasma. Our experiments directly demonstrated that different centrifugation methods produced distinct quantities of plasma microRNAs. Thus, exosomes or protein complexes containing microRNAs may be involved in large nanoparticle formation and may be precipitated after two-step centrifugation. Our results remind us that sample processing methods should be first considered in conducting research.

Evaluation of conventional castaneda and lysis centrifugation blood culture techniques for diagnosis of human brucellosis.

Science.gov (United States)

Mantur, Basappa G; Mangalgi, Smita S

2004-09-01

We investigated the role of the lysis centrifugation blood culture technique over the conventional Castaneda technique for the diagnosis of human brucellosis. The lysis centrifugation technique has been found to be more sensitive in both acute (20% higher sensitivity; P centrifugation was in the mean detection time, which was only 2.4 days in acute and 2.7 days in chronic cases, with 103 out of 110 (93.6%) and 17 out of 20 (85%) cultures from acute and chronic brucellosis, respectively, detected before the conventional culture was positive. Our results confirmed the potential usefulness of the lysis technique in diagnosis and institution of appropriate antibiotic therapy.

Test Results of a 1.2 kg/s Centrifugal Liquid Helium Pump for the ATLAS Superconducting Toroid Magnet System

CERN Document Server

Pengo, R; Passardi, Giorgio; Pirotte, O; ten Kate, H H J

2002-01-01

The toroid superconducting magnet of ATLAS-LHC experiment at CERN will be indirectly cooled by means of forced flow of liquid helium at about 4.5 K. A centrifugal pump will be used, providing a mass flow of 1.2 kg/s and a differential pressure of 40 kPa (ca. 400 mbar) at about 4300 rpm. Two pumps are foreseen, one for redundancy, in order to feed in parallel the cooling circuits of the Barrel and the two End-Caps toroid magnets. The paper describes the tests carried out at CERN to measure the characteristic curves, i.e. the head versus the mass flow at different rotational speeds, as well as the pump total efficiency. The pump is of the "fullemission" type, i.e. with curved blades and it is equipped with an exchangeable inducer. A dedicated pump test facility has been constructed at CERN, which includes a Coriolis-type liquid helium mass flow meter. This facility is connected to the helium refrigerator used for the tests at CERN of the racetrack magnets of the Barrel and of the End-Cap toroids.

Effect of centrifuge test on blood serum lipids index of cadet pilots.

Science.gov (United States)

Wochyński, Zbigniew; Kowalczuk, Krzysztof; Kłossowski, Marek; Sobiech, Krzysztof A

2016-01-01

This study aimed at investigating the relationship between the lipid index (WS) in the examined cadets and duration of exposure to +Gz in the human centrifuge. The study involved 19 first-year cadets of the Polish Air Force Academy in Dęblin. Tests in the human centrifuge were repeated twice, i.e. prior to (test I) and 45 days after (test II). After exposure to +Gz, the examined cadets were divided into 2 groups. Group I (N=11) included cadets subjected to a shorter total duration of exposure to +Gz, while group II (N=8) included cadets with a longer total duration of exposure to +Gz. Total cholesterol (TC), high density lipoprotein (HDL), triglycerides (TG), and apolipoproteins A1 and B were assayed in blood serum prior to (assay A) and after (assay B) both exposures to +Gz. Low density lipoprotein (LDL) level was estimated from the Friedewald formula. WS is an own mathematical algorithm. WS was higher in group II, assay A - 10.0 and B - 10.08 of test I in the human centrifuge than in group I where the WS values were 6.91 and 6.96, respectively. WS was also higher in group II in assay A - 10.0 and B -10.1 of test II in the human centrifuge than in group I - 6.96 and 6.80, respectively. The higher value of WS in group II, both after the first and second exposure to +Gz in human centrifuge, in comparison with group I, indicated its usefulness for determination of the maximum capability of applying acceleration of the interval type during training in the human centrifuge.

Gas centrifuge purge method

Science.gov (United States)

Theurich, Gordon R.

1976-01-01

1. In a method of separating isotopes in a high speed gas centrifuge wherein a vertically oriented cylindrical rotor bowl is adapted to rotate about its axis within an evacuated chamber, and wherein an annular molecular pump having an intake end and a discharge end encircles the uppermost portion of said rotor bowl, said molecular pump being attached along its periphery in a leak-tight manner to said evacuated chamber, and wherein end cap closure means are affixed to the upper end of said rotor bowl, and a process gas withdrawal and insertion system enters said bowl through said end cap closure means, said evacuated chamber, molecular pump and end cap defining an upper zone at the discharge end of said molecular pump, said evacuated chamber, molecular pump and rotor bowl defining a lower annular zone at the intake end of said molecular pump, a method for removing gases from said upper and lower zones during centrifuge operation with a minimum loss of process gas from said rotor bowl, comprising, in combination: continuously measuring the pressure in said upper zone, pumping gas from said lower zone from the time the pressure in said upper zone equals a first preselected value until the pressure in said upper zone is equal to a second preselected value, said first preselected value being greater than said second preselected value, and continuously pumping gas from said upper zone from the time the pressure in said upper zone equals a third preselected value until the pressure in said upper zone is equal to a fourth preselected value, said third preselected value being greater than said first, second and fourth preselected values.

Shaft cracks detection on operating centrifugal pumps by vibration analysis

International Nuclear Information System (INIS)

Serra, Reynaldo Cavalcanti.

1995-01-01

This study gives an account of the vibratory behaviour of one centrifugal pump representative of those employed in nuclear reactors whereby its shaft contained a fatigue crack with critical orientation. Two cracks depth were included in the study, aside from the uncracked shaft. Four other machined discontinuities with varying depths were also included to allow a direct comparison. The data acquisition was carried out with a system using eight accelerometers and a tape recorder. The signals were then processed and interpreted with a dynamic signal analysis work station. The data analysis based in the time domain were unsuccessful as a result of the signal complexity. The fundamental frequency and its harmonics were defined from the frequency spectra. The corresponding amplitudes were recorded and tabulated for future reference. A method was proposed to identify the evolution of the discontinuities based on the departures from a reference state and procedure is suggested to substitute the standards and practices presently in use which are unreliable. (author). 46 refs., 48 figs., 24 tabs

Residual blood processing by centrifugation, cell salvage or ultrafiltration in cardiac surgery: effects on clinical hemostatic and ex-vivo rheological parameters.

Science.gov (United States)

Vonk, Alexander B; Muntajit, Warayouth; Bhagirath, Pranav; van Barneveld, Laurentius J; Romijn, Johannes W; de Vroege, Roel; Boer, Christa

2012-10-01

The study compared the effects of three blood concentration techniques after cardiopulmonary bypass on clinical hemostatic and ex-vivo rheological parameters. Residual blood of patients undergoing elective cardiac surgery was processed by centrifugation, cell salvage or ultrafiltration, and retransfused (n = 17 per group). Study parameters included blood loss, (free) hemoglobin, hematocrit, fibrinogen and erythrocyte aggregation, deformability and 2,3-diphosphoglycerate content. Patient characteristics were similar between groups. Ultrafiltration was associated with the highest weight of the transfusion bag [649 ± 261 vs. 320 ± 134 g (centrifugation) and 391 ± 158 g (cell salvage); P levels in the transfusion bag. Retransfusion of cell saver blood induced the largest gain in postoperative patient hemoglobin levels when compared to centrifugation and ultrafiltration, and was associated with the largest increase in 2,3-diphosphoglycerate when compared to ultrafiltration (Δ2,3-diphosphoglycerate 1.34 ± 1.92 vs. -0.77 ± 1.56 mmol/l; P = 0.03). Cell salvage is superior with respect to postoperative hemoglobin gain and washout of free hemoglobin when compared to centrifugation or ultrafiltration.

The effect of centrifugation at various g force levels on rheological properties of rat, dog, pig and human red blood cells.

Science.gov (United States)

Kiss, Ferenc; Toth, Eniko; Miszti-Blasius, Kornel; Nemeth, Norbert

2016-01-01

Laboratory investigations often require centrifugation of blood samples for various erythrocyte tests. Although there is a lack of data about the effect of centrifugation at various g force levels on erythrocyte rheological properties. We aimed to investigate the effect of a 10-minute centrifugation at 500, 1000 or 1500 g at 15°C of rat, dog, pig and human venous (K3-EDTA, 1.5 mg/ml) blood samples. Hematological parameters, erythrocyte deformability, cell membrane stability, osmotic gradient ektacytometry (osmoscan) and erythrocyte aggregation were determined. Hematological and erythrocyte deformability parameters showed interspecies differences, centrifugation caused no significant alterations. Cell membrane stability for human erythrocytes centrifuged at higher g level showed less decrease in deformability. Osmoscan O min parameter showed slight elevation in dog centrifuged aliquots. Erythrocyte aggregation parameters changed unexpectedly. Rat and dog erythrocyte aggregation indices significantly dropped in centrifuged aliquots. Pig erythrocyte aggregation indices increased significantly after centrifugation. Human erythrocyte aggregation was the most stable one among the investigated species. The used centrifugation protocols caused the largest alterations in erythrocyte aggregation in a controversial way among the investigated species. On the other hand, erythrocyte deformability parameters were stable, cell membrane stability and osmoscan data show minor shifts.

Application of a magnetic fluid seal to rotary blood pumps

International Nuclear Information System (INIS)

Mitamura, Y; Arioka, S; Azegami, M; Sakota, D; Sekine, K

2008-01-01

A magnetic fluid seal enables mechanical contact-free rotation of a shaft without frictional heat and material wear and hence has excellent durability. However, the durability of a magnetic fluid seal decreases in liquid. The life of a seal applied to a rotary blood pump is not known. We have developed a magnetic fluid seal that has a shield mechanism minimizing the influence of the rotary pump on the magnetic fluid. The developed magnetic fluid seal worked for over 286 days in a continuous flow condition, for 24 days (on-going) in a pulsatile flow condition and for 24 h (electively terminated) in blood flow. The magnetic fluid seal is promising as a shaft seal for rotary blood pumps

Directly observed reversible shape changes and hemoglobin stratification during centrifugation of human and Amphiuma red blood cells.

Science.gov (United States)

Hoffman, Joseph F; Inoué, Shinya

2006-02-21

This paper describes changes that occur in human and Amphiuma red blood cells observed during centrifugation with a special microscope. Dilute suspensions of cells were layered, in a centrifuge chamber, above an osmotically matched dense solution, containing Nycodenz, Ficoll, or Percoll (Pharmacia) that formed a density gradient that allowed the cells to slowly settle to an equilibrium position. Biconcave human red blood cells moved downward at low forces with minimum wobble. The cells oriented vertically when the force field was increased and Hb sedimented as the lower part of each cell became bulged and assumed a "bag-like" shape. The upper centripetal portion of the cell became thinner and remained biconcave. These changes occurred rapidly and were completely reversible upon lowering the centrifugal force. Bag-shaped cells, upon touching red cells in rouleau, immediately reverted to biconcave disks as they flipped onto a stack. Amphiuma red cells displayed a different type of reversible stratification and deformation at high force fields. Here the cells became stretched, with the nucleus now moving centrifugally, the Hb moving centripetally, and the bottom of the cells becoming thinner and clear. Nevertheless, the distribution of the marginal bands at the cells' rim was unchanged. We conclude that centrifugation, per se, while changing a red cell's shape and the distribution of its intracellular constituents, does so in a completely reversible manner. Centrifugation of red cells harboring altered or missing structural elements could provide information on shape determinants that are still unexplained.

Fluid Dynamics in Rotary Piston Blood Pumps.

Science.gov (United States)

Wappenschmidt, Johannes; Sonntag, Simon J; Buesen, Martin; Gross-Hardt, Sascha; Kaufmann, Tim; Schmitz-Rode, Thomas; Autschbach, Ruediger; Goetzenich, Andreas

2017-03-01

Mechanical circulatory support can maintain a sufficient blood circulation if the native heart is failing. The first implantable devices were displacement pumps with membranes. They were able to provide a sufficient blood flow, yet, were limited because of size and low durability. Rotary pumps have resolved these technical drawbacks, enabled a growing number of mechanical circulatory support therapy and a safer application. However, clinical complications like gastrointestinal bleeding, aortic insufficiency, thromboembolic complications, and impaired renal function are observed with their application. This is traced back to their working principle with attenuated or non-pulsatile flow and high shear stress. Rotary piston pumps potentially merge the benefits of available pump types and seem to avoid their complications. However, a profound assessment and their development requires the knowledge of the flow characteristics. This study aimed at their investigation. A functional model was manufactured and investigated with particle image velocimetry. Furthermore, a fluid-structure interaction computational simulation was established to extend the laboratory capabilities. The numerical results precisely converged with the laboratory measurements. Thus, the in silico model enabled the investigation of relevant areas like gap flows that were hardly feasible with laboratory means. Moreover, an economic method for the investigation of design variations was established.

Effects of radial diffuser hydraulic design on a double-suction centrifugal pump

Science.gov (United States)

Hou, H. C.; Zhang, Y. X.; Xu, C.; Zhang, J. Y.; Li, Z. L.

2016-05-01

device and is good to transform the dynamic energy to pressure energy. Then through the hydraulic loss analysis of each pump component for all diffusers, it shows that the impeller takes up the biggest part of the whole loss about 8.19% averagely, the radial diffuser about 3.70% and the volute about 1.65%. The hydraulic loss of impeller is dominant at the large flow rate while the radial diffuser is at the small flow rate. Among all diffusers, the ES profile diffuser generates the least loss and combined to the distribution of velocity vector and turbulent kinetic energy for two kinds of diffusers it also shows that ES profile is fit to apply in radial diffuser. This research can offer a significant reference for the radial diffuser hydraulic design of such centrifugal pumps.

Tendency of nuclear pumps for PWR primary system

International Nuclear Information System (INIS)

Shibata, Takeshi

1976-01-01

At present, large PWR power stations of more than 1,000 MW are successively constructed, and the pumps used there have become large. The progress and tendency of the technical development of main pumps in primary system are described. The increase of the capacity of power stations is accomplished by increasing the circulating coolant quantity per loop or the number of loops. Same standard primary coolant pumps are employed in the plants from 500 to 1,100 MW. The type of primary coolant pumps changed from canned type to shaft seal type, and the advantages of the shaft seal type are cheap production cost, high efficiency, and the easy utilization of inertia force. The bearings and shaft seals are thermally insulated from primary coolant. As for auxiliary pumps, reciprocating filling-up pumps and centrifugal high pressure injection pumps are used for 500 MW plants, but only centrifugal pumps are used for both purposes in 800 MW plants, and in 1,100 MW plants, the pumps of both types for separate purposes and centrifugal pumps for combined purposes are installed. Horizontal or vertical pumps of same type are used as containment vessel-spraying pumps and excess heat-eliminating pumps. The type of boric acid pumps changed from canned type to mechanical seal type. (Kako, I.)

The Strength Calculation of the Pump Shaft with a Worn Impeller

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Nikolay P. Ovchinnikov

2017-12-01

Full Text Available Introduction: This paper presents the study of the impeller wear influence on stress-strain state of a centrifugal pump shaft. In agro-industrial sector, centrifugal pumps are used for watering various agricultural crops. During pumping water, a centrifugal pump impeller is usually a subject to influence of various irreversible physical-and-mechanical and physical-and-chemical processes that can result in a certain reduction in its mass. Materials and Methods: We used a comprehensive approach including the analysis of a sufficient number domestic and foreign publications on the research topic and parametric studies conducted on a laboratory-pumping unit. We had modern vibration-based diagnostic equipment, the mathematical models of loading a pump shaft and a finite-element modeling in APM Win Machine software (Beam module. Results: The comparison of the maximum equivalent dynamic stresses obtained according to the proposed method with existing methods for carrying out the checking strength calculation of a centrifugal pump shaft showed that account of the impeller wear significantly changes picture of stress-strain state shaft. Discussion and Conclusions: The amendments proposed by the author in checking strength calculation of a centrifugal pump shaft will allow estimating its stress-strain state in certain production situations.

[Pre-analytical stability before centrifugation of 7 biochemical analytes in whole blood].

Science.gov (United States)

Perrier-Cornet, Andreas; Moineau, Marie-Pierre; Narbonne, Valérie; Plee-Gautier, Emmanuelle; Le Saos, Fabienne; Carre, Jean-Luc

2015-01-01

The pre-analytical stability of 7 biochemical parameters (parathyroid hormone -PTH-, vitamins A, C E and D, 1,25-dihydroxyvitamin D and insulin) at +4 °C, was studied on whole blood samples before centrifugation. The impact of freezing at -20°C was also analyzed/performed for PTH and vitamin D. The differences in the results of assays for whole blood samples, being kept for different times between sampling time and analysis, from 9 healthy adults, were compaired by using a Student t test. The 7 analytes investigated remained stable up to 4 hours at +4°C in whole blood. This study showed that it is possible to accept uncentrifuged whole blood specimens kept at +4°C before analysis. PTH is affected by freezing whereas vitamin D is not.

Static pressure recovery analysis in the vane island diffuser of a centrifugal pump

Energy Technology Data Exchange (ETDEWEB)

Si, Qiaorui [National Research Center of Pumps, Jiangsu University, Zhenjiang (China); Dupont, Patrick; Bayeul-Laine, Annie-Claude; Dazin, Antoine; Roussette, Olivier; Bois, Gerard [LML, UMR CNRS 8107 Ecole Centrale de Lille, Lille (France)

2016-02-15

The overall performance of a vane-island type diffuser of a centrifugal pump model was obtained by means of directional probe traverses. These measurements were performed in an air model of a real hydraulic pump for five volume flow rates. Directional probe traverses are performed with a classical three-hole probe to cover most of the complete inlet section of the diffuser from hub to shroud and from pressure to suction side. Existing Particle image velocimetry (PIV) measurement results are also used to compare probe measurement results between the inlet and outlet throats of vane island diffuser at mid-span. Some assistance from already existing unsteady calculation, including leakage effects, is used to evaluate the numerical approach capability and to correctly define the mean initial conditions at impeller's outlet section. Pressure recovery and the measured total pressure loss levels inside this particular vane diffuser geometry are then calculated. Detailed analysis of the flow structure at the inlet section of the vane island diffuser is presented to focus on pressure evolution inside the entire diffuser section for different flow rates. The combined effects of incidence angle and blockage distributions along hub to shroud direction are found to play an important role on loss distribution in such a diffuser.

Quantification of platelets obtained by different centrifugation protocols in SHR rats

Directory of Open Access Journals (Sweden)

João Alberto Yazigi Junior

2015-12-01

Full Text Available ABSTRACT OBJECTIVE: To quantify the platelet concentration in the blood of SHR rats, by means of different centrifugation protocols, and to evaluate what the most effective method for obtaining platelets is. METHODS: We used 40 male rats of the isogenic SHR lineage. The animals were divided into three groups: control, using whole blood without centrifugation; single centrifugation, using whole blood subjected to a single centrifugation at 200 × gand 400 × g; and double centrifugation, using whole blood subjected one centrifugation at different rotations, followed by collection of whole plasma subjected to another centrifugation at different rotations: 200 × g+ 200 ×g; 200 × g+ 400 × g; 200 × g+ 800 × g; 400 ×g+ 400 × g; 400 × g+ 800 × g. Samples of 3 ml of blood were drawn from each animal by means of cardiac puncture. The blood was stored in Vacutainer collection tubes containing 3.2% sodium citrate. The blood from the control group animals was analyzed without being subjected to centrifugation. After the blood from the other groups of animals had been subjected to centrifugation, the whole plasma was collected and subjected to platelet counting in the lower third of the sample. RESULTS: We obtained greatest platelet enrichment in the subgroup with two centrifugations comprising 400 × gfor 10 min + 400 ×gfor 10 min, in which the mean platelet concentration was 11.30 times higher than that of the control group. CONCLUSION: It was possible to obtain a high platelet concentration using viable simple techniques, by means of centrifugation of whole blood and use of commonly used materials. The most effective method for obtaining platelet concentrate was found in samples subjected to two centrifugations.

A mini axial and a permanent maglev radial heart pump.

Science.gov (United States)

Qian, Kun-Xi; Ru, Wei-Min; Wang, Hao; Jing, Teng

2007-05-31

The implantability and durability have been for decades the focus of artificial heart R&D. A mini axial and a maglev radial pump have been developed to meet with such requirements.The mini axial pump weighing 27g (incl.5g rotor) has an outer diameter of 21mm and a length of 10mm in its largest point, but can produce a maximal blood flow of 6l/min with 50mmHg pressure increase. Therefore, it is suitable for the patients of 40-60kg body weight. For other patients of 60-80kg or 80-100kg body weight, the mini axial pumps of 23mm and 25mm outer diameter had been developed before, these devices were acknowledged to be the world smallest LVADs by Guinness World Record Center in 2004.The permanent maglev radial pump weighing 150g is a shaft-less centrifugal pump with permanent magnetic bearings developed by the author. It needs no second coil for suspension of the rotor except the motor coil, different from all other maglev pumps developed in USA, Japan, European, etc. Thus no detecting and controlling systems as well as no additional power supply for maglev are necessary. The pump can produce a blood flow up to as large as 10l/min against 100mmHg pressure.An implantable and durable blood pump will be a viable alternative to natural donor heart for transplantation.

Centrifugal Separation Device Based on Two-Layer Laminar Flow in Microchannels for High-Throughput and Continuous Blood Cell/Plasma Separation

Science.gov (United States)

Taizo Kobayashi,; Taisuke Funamoto,; Makoto Hosaka,; Satoshi Konishi,

2010-07-01

This paper presents a novel type of centrifugation device that is based on the two-layer laminar flow in micro flow channels for continuous blood cell/plasma separation. We propose to rotate the flow channels which are arranged along the circumference around the rotational axis. Downsizing the channel width reduced both the cell sedimentation time and the required centrifugal force, because the channel width corresponds to the centrifugal sedimentation length. First, plasma and cells were continuously extracted from pig blood in each of the branch channels using a milled acrylic prototype device (channel width = 800 μm, volume = 150 μl). Next, the relationship between the channel width (125, 250, and 500 μm) and the sedimentation time taken for various centrifugal forces (2.3, 9, 36, and 145 G) was evaluated using the downsized microchannels fabricated by hot-embossing and thermal bonding technologies. Using downsized microchannels with a width of 125 μm successfully reduced the sedimentation time to 85 s as compared to the sedimentation time of 270 s for a channel of a width of 500 μm, when a centrifugal force of 2.3 G was applied. The use of the proposed device did not result in obvious hemolysis at the centrifugal forces lower than 335 G.

The optimization of low specific speed centrifugal pump based on incomplete sensitivities

International Nuclear Information System (INIS)

Zhang, R H; Zheng, K; Shi, F X; Yao, L H

2012-01-01

In this research, the optimization method for low specific speed centrifugal pump impeller based on incomplete sensitivities was proposed. The main feature of the algorithm is that it avoids solving the flow field repeatedly in one optimization cycle in finite difference method and it avoids solving the adjoint equation in adjoint method. The blade meridional plan is considered as constant, and the blade camber line was parameterize by Taylor function. The coefficients in the Taylor function were taken as the control variable. The moment acting on the blade was considered as the objective function. With the incomplete sensitivities we can get the gradient of the objective function with respect to the control variable easily, and the blade shape can be renewed according to the inverse direction of the gradient. We will find the optimum design when the objective function is minimized. The computational cost is greatly reduced. The calculation cases show that the proposed theory and method is rotational.

Quantification of platelets obtained by different centrifugation protocols in SHR rats

OpenAIRE

João Alberto Yazigi Junior; João Baptista Gomes dos Santos; Bruno Rodrigues Xavier; Marcela Fernandes; Sandra Gomes Valente; Vilnei Mattiolli Leite

2015-01-01

ABSTRACT OBJECTIVE: To quantify the platelet concentration in the blood of SHR rats, by means of different centrifugation protocols, and to evaluate what the most effective method for obtaining platelets is. METHODS: We used 40 male rats of the isogenic SHR lineage. The animals were divided into three groups: control, using whole blood without centrifugation; single centrifugation, using whole blood subjected to a single centrifugation at 200 × gand 400 × g; and double centrifugation, usin...

An experimental investigation of pump as turbine for micro hydro application

International Nuclear Information System (INIS)

Raman, N; Hussein, I; Palanisamy, K; Foo, B

2013-01-01

This paper presents the results of an experimental investigation of a centrifugal pump working as turbine (PAT). An end suction centrifugal pump was tested in turbine mode at PAT experimental rig installed in the Mechanical Engineering Laboratory of Universiti Tenaga Nasional. The pump with specific speed of 15.36 (m, m 3 /s) was used in the experiment and the performance characteristic of the PAT was determined. The experiment showed that a centrifugal pump can satisfactorily be operated as turbine without any mechanical problems. As compared to pump operation, the pump was found to operate at higher heads and discharge values in turbine mode. The best efficiency point (BEP) in turbine mode was found to be lower than BEP in pump mode. The results obtained were also compared to the work of some previous researchers.

Influences of centrifugation on cells and tissues in liposuction aspirates: optimized centrifugation for lipotransfer and cell isolation.

Science.gov (United States)

Kurita, Masakazu; Matsumoto, Daisuke; Shigeura, Tomokuni; Sato, Katsujiro; Gonda, Koichi; Harii, Kiyonori; Yoshimura, Kotaro

2008-03-01

Although injective autologous fat transplantation is one of the most attractive options for soft-tissue augmentation, problems such as unpredictability and fibrosis resulting from fat necrosis limit its universal acceptance. Centrifugation is one of most common methods for overcoming these difficulties. This study was performed to investigate quantitatively the effects of centrifugation on liposuction aspirates to optimize centrifugal conditions for fat transplantation and isolation of adipose-derived stem cells. Liposuction aspirates, obtained from eight healthy female donors, were either not centrifuged or centrifuged at 400, 700, 1200, 3000, or 4200 g for 3 minutes. The volumes of the oil, adipose, and fluid portions and numbers of blood cells and adipose-derived cells in each portion were examined. The processed adipose tissues (1 ml) were injected into athymic mice, and grafts were harvested and weighed at 4 weeks. Morphologic alterations were observed using light and scanning electron microscopy. Centrifugation concentrated adipose tissues and adipose-derived stem cells in the adipose portion and partly removed red blood cells from the adipose portion. Centrifugation at more than 3000 g significantly damaged adipose-derived stem cells. Centrifugation enhanced graft take per 1 ml centrifuged adipose but reduced calculated graft take per 1 ml adipose before centrifugation. Excessive centrifugation can destroy adipocytes and adipose-derived stem cells, but appropriate centrifugation concentrates them, resulting in enhanced graft take. The authors tentatively recommend 1200 g as an optimized centrifugal force for obtaining good short- and long-term results in adipose transplantation.

Evaluating the role of low-speed centrifugation towards transfecting human peripheral blood mononuclear cell culture.

Science.gov (United States)

Majumdar, M; Ratho, R; Chawla, Y; Singh, M P

2014-01-01

The conventional method of transfection of suspension cells by chemical has proven to be very difficult. We present a new transfection protocol, wherein, low-speed centrifugation of cell culture plates immediately after adding the lipid: DNA complex significantly enhances the transfection efficiency. Peripheral blood mononuclear cells (PBMCs) were transfected with BLOCK-iT™ Fluorescent Oligo (scrambled siRNA) and lipofectamine complex using conventional and low-speed centrifugation modified transfection protocols. The efficiency of transfection was determined using flowcytometer and cell viability was checked using MTT assay. Incorporation of low-speed centrifugation significantly enhances the transfection efficiency of BLOCK-iT™ in the suspension culture of PBMCs as compared to conventional transfection method (99.8% vs 28.3%; P Centrifugation enhanced transfection (CET) technique is simple, time-saving and novel application without compromising the cell viability in the context of recently popular RNA interference in suspension cultures of PBMCs. This undemanding modification might be applicable to a wide variety of cell lines and solve crucial problem of researchers working with RNA interference in suspension cultures.

Preliminary validation of a new magnetic wireless blood pump.

Science.gov (United States)

Kim, Sung Hoon; Ishiyama, Kazushi; Hashi, Shuichiro; Shiraishi, Yasuyuki; Hayatsu, Yukihiro; Akiyama, Masatoshi; Saiki, Yoshikatsu; Yambe, Tomoyuki

2013-10-01

In general, a blood pump must be small, have a simple configuration, and have sufficient hydrodynamic performance. Herein, we introduce new mechanisms for a wireless blood pump that is small and simple and provides wireless and battery-free operation. To achieve wireless and battery-free operation, we implement magnetic torque and force control methods that use two external drivers: an external coil and a permanent magnet with a DC-motor, respectively. Power harvesting can be used to drive an electronic circuit for wireless monitoring (the observation of the pump conditions and temperature) without the use of an internal battery. The power harvesting will be used as a power source to drive other electronic devices, such as various biosensors with their driving circuits. To have both a compact size and sufficient pumping capability, the fully magnetic impeller has five stages and each stage includes four backward-curved blades. The pump has total and inner volumes of 20 and 9.8 cc, respectively, and weighs 52 g. The pump produces a flow rate of approximately 8 L/min at 80 mm Hg and the power generator produces 0.3 W of electrical power at 120 Ω. The pump also produces a minimum flow rate of 1.5 L/min and a pressure of 30 mm Hg for circulation at a maximum distance of 7.5 cm. © 2013 Wiley Periodicals, Inc. and International Center for Artificial Organs and Transplantation.

Sealing performance of a magnetic fluid seal for rotary blood pumps.

Science.gov (United States)

Mitamura, Yoshinori; Takahashi, Sayaka; Kano, Kentaro; Okamoto, Eiji; Murabayashi, Shun; Nishimura, Ikuya; Higuchi, Taka-Aki

2009-09-01

A magnetic fluid (MF) for a rotary blood pump seal enables mechanical contact-free rotation of the shaft and, hence, has excellent durability. The performance of a MF seal, however, has been reported to decrease in liquids. We have developed a MF seal that has a "shield" mechanism and a new MF with a higher magnetization of 47.9 kA/m. The sealing performance of the MF seal installed in a rotary blood pump was studied. Under the condition of continuous flow, the MF seal remained in perfect condition against a pressure of 298 mm Hg (pump flow rate: 3.96 L/min). The seal was also perfect against a pressure of 170 mm Hg in a continuous flow of 3.9 L/min for 275 days. We have developed a MF seal that works in liquid against clinically used pressures. The MF seal is promising as a shaft seal for rotary blood pumps.

Research and development on the hydraulic design system of the guide vanes of multistage centrifugal pumps

International Nuclear Information System (INIS)

Zhang, Q H; Xu, Y; Shi, W D; Lu, W G

2012-01-01

To improve the hydraulic design accuracy and efficiency of the guide vanes of the multistage centrifugal pumps, four different-structured guide vanes are investigated, and the design processes of those systems are established. The secondary development platforms of the ObjectArx2000 and the UG/NX OPEN are utilized to develop the hydraulic design systems of the guide vanes. The error triangle method is adopted to calculate the coordinates of the vanes, the profiles of the vanes are constructed by Bezier curves, and then the curves of the flow areas along the flow-path are calculated. Two-dimensional and three-dimensional hydraulic models can be developed by this system.

Outcomes and biochemical parameters following cardiac surgery: effects of transfusion of residual blood using centrifugation and multiple-pass hemoconcentration.

Science.gov (United States)

McNair, Erick; McKay, William; Qureshi, Abdul Mohamed; Rosin, Mark; Gamble, Jon; Dalshaug, Greg; Mycyk, Taras; Prasad, Kailash

2013-12-01

To determine whether or not there was a significant difference between the methods of centrifugation (CF) and multiple-pass hemoconcentration (MPH) of the residual cardiopulmonary-bypass volume in relation to biochemical measurements and patient outcomes. Prospective, randomized, and controlled. Conducted at a western Canadian tertiary care hospital. Consisted of 61 consecutive male and female patients from ages 40 to 80 who were scheduled for cardiac surgery with cardiopulmonary bypass. Either the centrifugation or multiple-pass hemoconcentration method was used to process the residual blood from the cardiopulmonary bypass circuit. The 12-hour postoperative levels of serum hemoglobin were not significantly different in the centrifugation group as compared to the multiple-pass hemoconcentration group. However, the serum levels of total protein and albumin were significantly higher in the multiple-pass hemoconcentration group as compared to the centrifugation group. Additionally, after 12-hours postoperatively, the serum fibrinogen and platelet counts were significantly higher in the multiple-pass hemoconcentration group as compared to those of the centrifugation group. The allogeneic product transfusion index and the chest-tube blood drainage indices were lower in the multiple-pass hemoconcentration group as compared to the centrifugation group. Although the CF method provided a product in a shorter turnaround time, with consistent clearance of heparin, the MPH method trended towards enhanced biochemical and clinical patient outcomes over the 12-hour postoperative period. Copyright © 2013 Elsevier Inc. All rights reserved.

A Mini Axial and a Permanent Maglev Radial Heart Pump§

Science.gov (United States)

Qian, Kun-Xi; Ru, Wei-Min; Wang, Hao; Jing, Teng

2007-01-01

The implantability and durability have been for decades the focus of artificial heart R&D. A mini axial and a maglev radial pump have been developed to meet with such requirements. The mini axial pump weighing 27g (incl.5g rotor) has an outer diameter of 21mm and a length of 10mm in its largest point, but can produce a maximal blood flow of 6l/min with 50mmHg pressure increase. Therefore, it is suitable for the patients of 40-60kg body weight. For other patients of 60-80kg or 80-100kg body weight, the mini axial pumps of 23mm and 25mm outer diameter had been developed before, these devices were acknowledged to be the world smallest LVADs by Guinness World Record Center in 2004. The permanent maglev radial pump weighing 150g is a shaft-less centrifugal pump with permanent magnetic bearings developed by the author. It needs no second coil for suspension of the rotor except the motor coil, different from all other maglev pumps developed in USA, Japan, European, etc. Thus no detecting and controlling systems as well as no additional power supply for maglev are necessary. The pump can produce a blood flow up to as large as 10l/min against 100mmHg pressure. An implantable and durable blood pump will be a viable alternative to natural donor heart for transplantation. PMID:19662120

Quantification of platelets obtained by different centrifugation protocols in SHR rats.

Science.gov (United States)

Yazigi Junior, João Alberto; Dos Santos, João Baptista Gomes; Xavier, Bruno Rodrigues; Fernandes, Marcela; Valente, Sandra Gomes; Leite, Vilnei Mattiolli

2015-01-01

To quantify the platelet concentration in the blood of SHR rats, by means of different centrifugation protocols, and to evaluate what the most effective method for obtaining platelets is. We used 40 male rats of the isogenic SHR lineage. The animals were divided into three groups: control, using whole blood without centrifugation; single centrifugation, using whole blood subjected to a single centrifugation at 200 × g and 400 × g; and double centrifugation, using whole blood subjected one centrifugation at different rotations, followed by collection of whole plasma subjected to another centrifugation at different rotations: 200 × g + 200 × g; 200 × g + 400 × g; 200 × g + 800 × g; 400 × g + 400 × g; 400 × g + 800 × g. Samples of 3 ml of blood were drawn from each animal by means of cardiac puncture. The blood was stored in Vacutainer collection tubes containing 3.2% sodium citrate. The blood from the control group animals was analyzed without being subjected to centrifugation. After the blood from the other groups of animals had been subjected to centrifugation, the whole plasma was collected and subjected to platelet counting in the lower third of the sample. We obtained greatest platelet enrichment in the subgroup with two centrifugations comprising 400 × g for 10 min + 400 × g for 10 min, in which the mean platelet concentration was 11.30 times higher than that of the control group. It was possible to obtain a high platelet concentration using viable simple techniques, by means of centrifugation of whole blood and use of commonly used materials. The most effective method for obtaining platelet concentrate was found in samples subjected to two centrifugations.

Pump trials for charged liquids

International Nuclear Information System (INIS)

Moroni, J.C.; Niver, A.

1964-01-01

The pumps intended for the circulation of charged and radioactive liquids have particular qualities. The choice of such a pump has called for endurance tests with various types of equipment: a Goodyear volumetric screw pumps, and RICHIER, Klein and SCHABAVER centrifugal pumps. The latter, fitted with a special oakum, gave the best results. (authors) [fr

Comparison of PCR-Based Diagnosis with Centrifuged-Based Enrichment Method for Detection of Borrelia persica in Animal Blood Samples.

Science.gov (United States)

Naddaf, S R; Kishdehi, M; Siavashi, Mr

2011-01-01

The mainstay of diagnosis of relapsing fever (RF) is demonstration of the spirochetes in Giemsa-stained thick blood smears, but during non fever periods the bacteria are very scanty and rarely detected in blood smears by microscopy. This study is aimed to evaluate the sensitivity of different methods developed for detection of low-grade spirochetemia. Animal blood samples with low degrees of spirochetemia were tested with two PCRs and a nested PCR targeting flaB, GlpQ, and rrs genes. Also, a centrifuged-based enrichment method and Giemsa staining were performed on blood samples with various degrees of spirochetemia. The flaB-PCR and nested rrs-PCR turned positive with various degrees of spirochetemia including the blood samples that turned negative with dark-field microscopy. The GlpQ-PCR was positive as far as at least one spirochete was seen in 5-10 microscopic fields. The sensitivity of GlpQ-PCR increased when DNA from Buffy Coat Layer (BCL) was used as template. The centrifuged-based enrichment method turned positive with as low concentration as 50 bacteria/ml blood, while Giemsa thick staining detected bacteria with concentrations ≥ 25000 bacteria/ml. Centrifuged-based enrichment method appeared as much as 500-fold more sensitive than thick smears, which makes it even superior to some PCR assays. Due to simplicity and minimal laboratory requirements, this method can be considered a valuable tool for diagnosis of RF in rural health centers.

Biochemical assessment of growth factors and circulation of blood components contained in the different fractions obtained by centrifugation of venous blood.

Science.gov (United States)

Corigiano, M; Ciobanu, G; Baldoni, E; Pompa, G

2014-01-01

The aim of this study was to evaluate a biochemical marker with different elements of a normal blood serum and centrifuged blood serum after a different rotation system. For this technique, we used five fractions of a blood Concentrated Growth Factors system (bCGF) and a particular device for the different rotation program. Blood samples were collected from 10 volunteers aged between 35 and 55 in the Operative Unit of the “Sapienza” University of Rome with only a fraction of different biochemical elements. Through an individual blood phase separator tube of venous blood, active factions of serum and 4 fractions of red buffy coat were taken. The biochemical markers with 14 elements were examined at times: P1-11 minutes, P2-12minutes, P3-15 minutes. Exclusively biological materials which are normally applied in the regeneration techniques for different defects and lesions were used with this technique. After specific rotation programs, a different result was obtained for each cycle: P1, P2, P3. In test tubes obtained by separated blood, we observed a higher concentration of proteins, ions, and other antigens compared to normal blood plasma. Examining the biochemical results of different elements, we observed an increase (P≤0,01). Since each person’s DNA is different, we could not have the same results in 5 fractions of blood concentration, we did, however, find a good increase in only a fraction of proteins, immunoglobulin and different ions. We obtained five fractions after centrifugation, and we had an increase in different biochemical elements compared to normal blood (P≤0,01) which is significant at different times. These biochemical elements were stimulated by different growth factors, which are used by the immune system, and they induced the formation of hard and soft tissues and good regeneration.

Removal of cellular-type hemoglobin-based oxygen carrier (hemoglobin-vesicles) from blood using centrifugation and ultrafiltration.

Science.gov (United States)

Sakai, Hiromi; Sou, Keitaro; Horinouchi, Hirohisa; Tsuchida, Eishun; Kobayashi, Koichi

2012-02-01

The hemoglobin-vesicle (HbV) is an artificial oxygen carrier encapsulating a concentrated hemoglobin solution in a phospholipid vesicle (liposome). During or after transporting oxygen, macrophages capture HbVs in the reticuloendothelial system (RES) with an approximate circulation half-life of 3 days. Animal studies show transient splenohepatomegaly after large doses, but HbVs were completely degraded, and the components were excreted in a few weeks. If a blood substitute is used for emergency use until red blood cell transfusion becomes available or for temporary use such as a priming fluid for an extracorporeal circuit, then one option would be to remove HbVs from the circulating blood without waiting a few weeks for removal by the RES. Using a mixture of beagle dog whole blood and HbV, we tested the separation of HbV using a centrifugal Fresenius cell separator and an ultrafiltration system. The cell separator system separated the layers of blood cell components from the HbV-containing plasma layer by centrifugal force, and then the HbV was removed from plasma phase by the ultrafiltration system. The HbVs (250-280 nm) are larger than plasma proteins (blood cell components (> 3 µm). The size of HbVs is advantageous to be separated from the original blood components, and the separated blood components can be returned to circulation. © 2011, Copyright the Authors. Artificial Organs © 2011, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

Multi-point optimization on meridional shape of a centrifugal pump impeller for performance improvement

Energy Technology Data Exchange (ETDEWEB)

Pei, Ji; Wang, Wen Jie; Yuan, Shouqi [National Research Center of Pumps, Jiangsu University, Zhenjiang (China)

2016-11-15

A wide operating band is important for a pump to safely perform at maximum efficiency while saving energy. To widen the operating range, a multi-point optimization process based on numerical simulations in order to improve impeller performance of a centrifugal pump used in nuclear plant applications is proposed by this research. The Reynolds average Navier Stokes equations are utilized to perform the calculations. The meridional shape of the impeller was optimized based on the following four parameters; shroud arc radius, hub arc radius, shroud angle, and hub angle as the design variables. Efficiencies calculated under 0.6Qd, 1.0Qd and 1.62Qd were selected as the three optimized objectives. The Design of experiment method was applied to generate various impellers while 35 impellers were generated by the Latin hypercube sampling method. A Response surface function based on a second order function was applied to construct a mathematical relationship between the objectives and design variables. A multi-objective genetic algorithm was utilized to solve the response surface function to obtain the best optimized objectives as well as the best combination of design parameters. The results indicated that the pump performance predicted by numerical simulation was in agreement with the experimental performance. The optimized efficiencies based on the three operating conditions were increased by 3.9 %, 6.1 % and 2.6 %, respectively. In addition, the velocity distribution, pressure distribution, streamline and turbulence kinetic energy distribution of the optimized and reference impeller were compared and analyzed to illustrate the performance improvement.

Multi-point optimization on meridional shape of a centrifugal pump impeller for performance improvement

International Nuclear Information System (INIS)

Pei, Ji; Wang, Wen Jie; Yuan, Shouqi

2016-01-01

A wide operating band is important for a pump to safely perform at maximum efficiency while saving energy. To widen the operating range, a multi-point optimization process based on numerical simulations in order to improve impeller performance of a centrifugal pump used in nuclear plant applications is proposed by this research. The Reynolds average Navier Stokes equations are utilized to perform the calculations. The meridional shape of the impeller was optimized based on the following four parameters; shroud arc radius, hub arc radius, shroud angle, and hub angle as the design variables. Efficiencies calculated under 0.6Qd, 1.0Qd and 1.62Qd were selected as the three optimized objectives. The Design of experiment method was applied to generate various impellers while 35 impellers were generated by the Latin hypercube sampling method. A Response surface function based on a second order function was applied to construct a mathematical relationship between the objectives and design variables. A multi-objective genetic algorithm was utilized to solve the response surface function to obtain the best optimized objectives as well as the best combination of design parameters. The results indicated that the pump performance predicted by numerical simulation was in agreement with the experimental performance. The optimized efficiencies based on the three operating conditions were increased by 3.9 %, 6.1 % and 2.6 %, respectively. In addition, the velocity distribution, pressure distribution, streamline and turbulence kinetic energy distribution of the optimized and reference impeller were compared and analyzed to illustrate the performance improvement

Numerical simulation of 3-D turbulent flow through entire stage in a multistage centrifugal pump

International Nuclear Information System (INIS)

Huang, S.; Islam, M.F.; Liu, P.

2005-01-01

A three-dimensional turbulent flow through a multistage centrifugal pump is numerically simulated using a commercial CFD software package. The simulation and analysis include flow fields in rotating impeller and stationary diffuser and is completed in a multiple reference frame. The standard k-ε turbulence model is applied. The analysis of the simulation reveals that the reverse flows exist in the zone near the impeller exit and diffuser entrance, resulting in flow field asymmetric and unsteady. There is a considerable interference on velocity field at impeller exit due to the interaction between impeller blades and diffuser vanes. The hydraulic performance is connected and evaluated with the 3-D computational flow field. The current computation is verified by comparing predicted and measured head. (author)

Centrifugation speed affects light transmission aggregometry.

Science.gov (United States)

Merolla, M; Nardi, M A; Berger, J S

2012-02-01

Light transmission aggregometry (LTA) is considered the gold standard for investigating platelet activity ex vivo. However, LTA protocols are not standardized, and differences in LTA procedure are a potential source of variance in results. Centrifugation speed is an essential component of platelet preparation in LTA, has yet to be standardized, and may affect platelet aggregation results. We sought to investigate the effect of relative centrifugal force (RCF) intensity on LTA results. Ten healthy controls had venous blood drawn and centrifuged at 150, 200, 300, and 500 g for 10 min. Cell counts in whole blood and platelet-rich plasma (PRP) were measured using a hematology analyzer. LTA was performed using 1.0 μm adenosine diphosphate (ADP) and 0.4 μm epinephrine as an agonist. Aggregation (%) was compared at 60, 120, 180, and 300 s and at maximum aggregation. Centrifugation speed was associated with decreasing platelet count (P centrifuge RCF at 60, 120, 180, 300 s and at maximum aggregation (P centrifugation speed in the interpretation of LTA results, supporting the need for standardization of centrifugation RCF in LTA protocols. © 2011 Blackwell Publishing Ltd.

Pumping machinery theory and practice

CERN Document Server

Badr, Hassan M

2014-01-01

Pumping Machinery Theory and Practice comprehensively covers the theoretical foundation and applications of pumping machinery. Key features: Covers characteristics of centrifugal pumps, axial flow pumps and displacement pumpsConsiders pumping machinery performance and operational-type problemsCovers advanced topics in pumping machinery including multiphase flow principles, and two and three-phase flow pumping systemsCovers different methods of flow rate control and relevance to machine efficiency and energy consumptionCovers different methods of flow rate control and relevance to machine effi

Evaluating the role of low-speed centrifugation towards transfecting human peripheral blood mononuclear cell culture

Directory of Open Access Journals (Sweden)

M Majumdar

2014-01-01

Full Text Available The conventional method of transfection of suspension cells by chemical has proven to be very difficult. We present a new transfection protocol, wherein, low-speed centrifugation of cell culture plates immediately after adding the lipid: DNA complex significantly enhances the transfection efficiency. Peripheral blood mononuclear cells (PBMCs were transfected with BLOCK-iT™ Fluorescent Oligo (scrambled siRNA and lipofectamine complex using conventional and low-speed centrifugation modified transfection protocols. The efficiency of transfection was determined using flowcytometer and cell viability was checked using MTT assay. Incorporation of low-speed centrifugation significantly enhances the transfection efficiency of BLOCK-iT™ in the suspension culture of PBMCs as compared to conventional transfection method (99.8% vs 28.3%; P < 0.0001, even at a low concentration of 40 picomoles without affecting the cell viability. Centrifugation enhanced transfection (CET technique is simple, time-saving and novel application without compromising the cell viability in the context of recently popular RNA interference in suspension cultures of PBMCs. This undemanding modification might be applicable to a wide variety of cell lines and solve crucial problem of researchers working with RNA interference in suspension cultures.

Kinetically limited differential centrifugation as an inexpensive and readily available alternative to centrifugal elutriation.

Science.gov (United States)

Tan, Jinwang; Lee, Byung-Doo; Polo-Parada, Luis; Sengupta, Shramik

2012-08-01

When separating two species with similar densities but differing sedimentation velocities (because of differences in size), centrifugal elutriation is generally the method of choice. However, a major drawback to this approach is the requirement for specialized equipment. Here, we present a new method that achieves similar separations using standard benchtop centrifuges by loading the seperands as a layer on top of a dense buffer of a specified length, and running the benchtop centrifugation process for a calculated amount of time, thereby ensuring that all faster moving species are collected at the bottom, while all slower moving species remain in the buffer. We demonstrate the use of our procedure to isolate bacteria from blood culture broth (a mixture of bacterial growth media, blood, and bacteria).

Reactor having coolant recycling pump

International Nuclear Information System (INIS)

Goto, Tadashi; Karatsuka, Shigeki; Yamamoto, Hajime.

1991-01-01

In a coolant recycling pump for an LMFBR type reactor, vertical grooves are formed to a static portion which surrounds a pump shaft as far as the lower end thereof. Sodium mists present in an annular gap of the pump shaft form a rotational flow, lose its centrifugal force at the grooved portion and are collected positively to the grooved portion. Further, since the rotational flow in the grooved channel is in a state of a cavity flow, the pressure is released in the grooved portion and a secondary eddy current is formed thereby providing a depressurized state. Accordingly, by a synergestic effect of the centrifugal force and the cavity flow, sodium mists can be recovered completely. (T.M.)

METHOD FOR OPTIMIZING THE ENERGY OF PUMPS

NARCIS (Netherlands)

Skovmose Kallesøe, Carsten; De Persis, Claudio

2013-01-01

The device for energy-optimization on operation of several centrifugal pumps controlled in rotational speed, in a hydraulic installation, begins firstly with determining which pumps as pilot pumps are assigned directly to a consumer and which pumps are hydraulically connected in series upstream of

Development of a magnetic fluid shaft seal for an axial-flow blood pump.

Science.gov (United States)

Sekine, Kazumitsu; Mitamura, Yoshinori; Murabayashi, Shun; Nishimura, Ikuya; Yozu, Ryouhei; Kim, Dong-Wook

2003-10-01

A rotating impeller in a rotary blood pump requires a supporting system in blood, such as a pivot bearing or magnetic suspension. To solve potential problems such as abrasive wear and complexity of a supporting system, a magnetic fluid seal was developed for use in an axial-flow blood pump. Sealing pressures at motor speeds of up to 8,000 rpm were measured with the seal immersed in water or bovine blood. The sealing pressure was about 200 mm Hg in water and blood. The calculated theoretical sealing pressure was about 230 mm Hg. The seal remained perfect for 743 days in a static condition and for 180+ days (ongoing test) at a motor speed of 7,000 rpm. Results of measurement of cell growth activity indicated that the magnetic fluid has no negative cytological effects. The specially designed magnetic fluid shaft seal is useful for an axial-flow blood pump.

Detection of pump degradation

International Nuclear Information System (INIS)

Casada, D.

1994-01-01

There are a variety of stressors that can affect the operation of centrifugal pumps. Although these general stressors are active in essentially all centrifugal pumps, the stressor level and the extent of wear and degradation can vary greatly. Parameters that affect the extent of stressor activity are manifold. In order to assure the long-term operational readiness of a pump, it is important to both understand the nature and magnitude of the specific degradation mechanisms and to monitor the performance of the pump. The most commonly applied method of monitoring the condition of not only pumps, but rotating machinery in general, is vibration analysis. Periodic or continuous spectral vibration analysis is a cornerstone of most pump monitoring programs. In the nuclear industry, non-spectral vibration monitoring of safety-related pumps is performed in accordance with the ASME code. Although vibration analysis has dominated the condition monitoring field for many years, there are other measures that have been historically used to help understand pump condition: advances in historically applied technologies and developing technologies offer improved monitoring capabilities. The capabilities of several technologies (including vibration analysis, dynamic pressure analysis, and motor power analysis) to detect the presence and magnitude of both stressors and resultant degradation are discussed

LOX/LH2 vane pump for auxiliary propulsion systems

Science.gov (United States)

Hemminger, J. A.; Ulbricht, T. E.

1985-01-01

Positive displacement pumps offer potential efficiency advantages over centrifugal pumps for future low thrust space missions. Low flow rate applications, such as space station auxiliary propulsion or dedicated low thrust orbiter transfer vehicles, are typical of missions where low flow and high head rise challenge centrifugal pumps. The positive displacement vane pump for pumping of LOX and LH2 is investigated. This effort has included: (1) a testing program in which pump performance was investigated for differing pump clearances and for differing pump materials while pumping LN2, LOX, and LH2; and (2) an analysis effort, in which a comprehensive pump performance analysis computer code was developed and exercised. An overview of the theoretical framework of the performance analysis computer code is presented, along with a summary of analysis results. Experimental results are presented for pump operating in liquid nitrogen. Included are data on the effects on pump performance of pump clearance, speed, and pressure rise. Pump suction performance is also presented.

Detection of pump degradation

International Nuclear Information System (INIS)

Casada, D.

1995-01-01

There are a variety of stressors that can affect the operation of centrifugal pumps. Although these general stressors are active in essentially all centrifugal pumps, the stressor level and the extent of wear and degradation can vary greatly. Parameters that affect the extent of stressor activity are manifold. In order to assure the long-term operational readiness of a pump, it is important to both understand the nature and magnitude of the specific degradation mechanisms and to monitor the performance of the pump. The most commonly applied method of monitoring the condition of not only pumps, but rotating machinery in general, is vibration analysis. Periodic or continuous special vibration analysis is a cornerstone of most pump monitoring programs. In the nuclear industry, non-spectral vibration monitoring of safety-related pumps is performed in accordance with the ASME code. Pump head and flow rate are also monitored, per code requirements. Although vibration analysis has dominated the condition monitoring field for many years, there are other measures that have been historically used to help understand pump condition; advances in historically applied technologies and developing technologies offer improved monitoring capabilities. The capabilities of several technologies (including vibration analysis, dynamic pressure analysis, and motor power analysis) to detect the presence and magnitude of both stressors and resultant degradation are discussed

40 CFR 65.116 - Quality improvement program for pumps.

Science.gov (United States)

2010-07-01

... (for example, piston, horizontal or vertical centrifugal, gear, bellows); pump manufacturer; seal type and manufacturer; pump design (for example, external shaft, flanged body); materials of construction... program. (4) Pump or pump seal inspection. The owner or operator shall inspect all pumps or pump seals...

Comparison of PCR-Based Diagnosis with Centrifuged-Based Enrichment Method for Detection of Borrelia Persica in Animal Blood Samples

Directory of Open Access Journals (Sweden)

SR Naddaf

2011-06-01

Full Text Available Background: The mainstay of diagnosis of relapsing fever (RF is demonstration of the spirochetes in Giemsa-stained thick blood smears, but during non fever periods the bacteria are very scanty and rarely detected in blood smears by mi­cros­copy. This study is aimed to evaluate the sensitivity of different methods developed for detection of low-grade spi­ro­chetemia. Methods: Animal blood samples with low degrees of spirochetemia were tested with two PCRs and a nested PCR tar­get­ing flaB, GlpQ, and rrs genes. Also, a centrifuged-based enrichment method and Giemsa staining were per­formed on blood samples with various degrees of spirochetemia. Results: The flaB-PCR and nested rrs-PCR turned positive with various degrees of spirochetemia including the blood samples that turned negative with dark-field microscopy. The GlpQ-PCR was positive as far as at least one spi­ro­chete was seen in 5-10 microscopic fields. The sensitivity of GlpQ-PCR increased when DNA from Buffy Coat Layer (BCL was used as template. The centrifuged-based enrichment method turned positive with as low concentra­tion as 50 bacteria/ml blood, while Giemsa thick staining detected bacteria with concentrations ≥ 25000 bacteria/ml. Conclusion: Centrifuged-based enrichment method appeared as much as 500-fold more sensitive than thick smears, which makes it even superior to some PCR assays. Due to simplicity and minimal laboratory requirements, this method can be considered a valuable tool for diagnosis of RF in rural health centers.

Comparison of PCR-Based Diagnosis with Centrifuged-Based Enrichment Method for Detection of Borrelia persica in Animal Blood Samples

Directory of Open Access Journals (Sweden)

SR Naddaf

2011-06-01

Background: The mainstay of diagnosis of relapsing fever (RF is demonstration of the spirochetes in Giemsa-stained thick blood smears, but during non fever periods the bacteria are very scanty and rarely detected in blood smears by mi­cros­copy. This study is aimed to evaluate the sensitivity of different methods developed for detection of low-grade spi­ro­chetemia. Methods: Animal blood samples with low degrees of spirochetemia were tested with two PCRs and a nested PCR tar­get­ing flaB, GlpQ, and rrs genes. Also, a centrifuged-based enrichment method and Giemsa staining were per­formed on blood samples with various degrees of spirochetemia. Results: The flaB-PCR and nested rrs-PCR turned positive with various degrees of spirochetemia including the blood samples that turned negative with dark-field microscopy. The GlpQ-PCR was positive as far as at least one spi­ro­chete was seen in 5-10 microscopic fields. The sensitivity of GlpQ-PCR increased when DNA from Buffy Coat Layer (BCL was used as template. The centrifuged-based enrichment method turned positive with as low concentra­tion as 50 bacteria/ml blood, while Giemsa thick staining detected bacteria with concentrations ≥ 25000 bacteria/ml.  Conclusion: Centrifuged-based enrichment method appeared as much as 500-fold more sensitive than thick smears, which makes it even superior to some PCR assays. Due to simplicity and minimal laboratory requirements, this method can be considered a valuable tool for diagnosis of RF in rural health centers.  

A Novel Centrifugation Method Using a Cell Salvage Device Offers an Alternative to the Use of Leukocyte-Depleting Filters for Autologous Blood Transfusions.

Science.gov (United States)

Barchilon, Michael; Gaspar, Cristina; Mexas, Angela; Nieter, Don

2016-12-01

Autotransfusion protocols often use the use of costly filters, such as leukocyte-depleting filters (LDFs), to minimize reinfusion of activated leukocytes and inflammatory mediators associated with reperfusion injury (RI). LDFs are used extensively in hospital settings; however, they represent an additional capital expenditure for hospitals, as well as a constraint on the reinfusion rate of blood products for health-care providers. We compared a commonly used LDF to a novel centrifugation method employing a widely used cell salvage device. Complete blood counts and enzyme-linked immunosorbent assays (ELISAs) measuring tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2) were performed to compare the efficacy of these methodologies. The LDF removed, on average, 94% of all leukocytes, including 96% of neutrophils. The centrifugation method removed, on average, 89% of all leukocytes, including 91% of neutrophils and resulted in a highly concentrated red blood cell product. Our results suggest both methods offer equivalent leukocyte reduction. TNF-α was also comparably reduced following our novel centrifugation method and the LDF method and IL-2 levels were undetectable in all samples. These results indicate our novel centrifugation method may preclude the need for a LDF during select autotransfusion applications.

Development of a 3D circular microfluidic centrifuge for the separation of mixed particles by using their different centrifuge times

International Nuclear Information System (INIS)

Jeon, H J; Kim, D I; Kim, M J; Nguyen, X D; Park, D H; Go, J S

2015-01-01

This paper presents a circular microfluidic centrifuge with two inlets and two outlets to separate mixed microparticles with a specially designed sample injection hole. To separate the mixed particles, it uses a rotational flow, generated in a chamber by counter primary flows in the microchannels. The shape and sizes of the circular microfluidic centrifuge have been designed through numerical evaluation to have a large relative centrifugal force. The difference of centrifuge times of the mixed particles of 1 μm and 6 μm was determined to be 8.2 s at an inlet Reynolds number of 500 and a sample Reynolds number of 20. In the experiment, this was measured to be about 10 s. From the separation of the two polymer particles analogous to the representative sizes of platelets and red blood cells, the circular microfluidic centrifuge shows a potential to separate human blood cells size-selectively by using the difference of centrifuge times. (paper)

21 CFR 864.9285 - Automated cell-washing centrifuge for immuno-hematology.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Automated cell-washing centrifuge for immuno... Establishments That Manufacture Blood and Blood Products § 864.9285 Automated cell-washing centrifuge for immuno-hematology. (a) Identification. An automated cell-washing centrifuge for immuno-hematology is a device used...

Designing a combined casting mold for manufacture of a gasoline centrifugal pump body using CAD/CAM-systems

Science.gov (United States)

Galin, N. E.; Ogol, I. I.; Chervach, Yu B.; Dammer, V. Kh; Ru, Jia Hong

2017-02-01

The present paper examines designing of a combined casting mold for manufacture of a gasoline centrifugal pump body. The paper offers technological solutions for obtaining high quality castings at the testing stage of the finished mold. The paper is intended for practical use and prepared by order of JSC ‘Tomsk Electrical Engineering Plant’ using software and equipment of the department ‘Technologies of Computer-Aided Machinery Manufacturing’ of the Tomsk Polytechnic University (TPU) under the economic contract within state import substitution program. In preparing the paper, CAD/CAM-systems KOMPAS-3D and PowerMILL were used. In 2015, the designed casting mold was introduced into the production process at JSC ‘Tomsk Electrical Engineering Plant’.

Simulating of single phase flow in typical centrifugal pumps oil industry; Simulacao do escoamento monofasico em bombas centrifugas tipicas da industria do petroleo

Energy Technology Data Exchange (ETDEWEB)

Andrade, Ana Carla Costa; Silva, Aldrey Luis Morais da; Maitelli, Carla Wilza Souza de Paula [Universidade Federal do Rio Grande do Norte (UFRN), RN (Brazil)

2012-07-01

With the various techniques applied in production processes and oil exploration, has been using the artificial lift equipment with the aim of promoting an increase in flow in oil wells and gas. Choosing the most appropriate method of elevation depends on certain factors, among them the initial costs of installation, maintenance and conditions in the producing field, resulting in a more precise analysis of the project. Although there are other methods that represent a low cost and easy maintenance, the BCS method (Electrical Submersible Pumping), appears to be quite effective when it is intended to pump more flow of liquids from both terrestrial and marine environments, in conditions adverse temperature, presence of free gas in the mixture and viscous fluids. This method is based in most cases where the vessel pressure was low, and the fluid does not reach the surface without intervention of an artificial means which can lift them. Similar happens at the end of productive life of a resurgence for the well, or even when the flow of it is far below what is expected to produce, requiring a complement of natural energy through artificial lift. By definition, the BCS is a method of artificial lift in which a subsurface electric motor turns electrical energy into mechanical centrifugal pump and a multistage overlapping converts mechanical energy into kinetic energy of the engine bringing the fluid surface. In this study we performed computer simulations using a commercial program ANSYS #Registered Sign# CFX #Registered Sign# dimensions previously obtained by the 3D geometry in CAD format, with the objective of evaluating the single-phase flow inside typical centrifugal pump submerged in the oil industry. The variable measured was the height of elevation and drilling fluids are oil and water.(author)

Pump Propels Liquid And Gas Separately

Science.gov (United States)

Harvey, Andrew; Demler, Roger

1993-01-01

Design for pump that handles mixtures of liquid and gas efficiently. Containing only one rotor, pump is combination of centrifuge, pitot pump, and blower. Applications include turbomachinery in powerplants and superchargers in automobile engines. Efficiencies lower than those achieved in separate components. Nevertheless, design is practical and results in low consumption of power.

PLC-Based Pressure Control in Multi-Pump Applications

Directory of Open Access Journals (Sweden)

Vodovozov Valery

2015-12-01

Full Text Available The paper is devoted to the centrifugal pumps represented the most popular type of pumping equipment used in different areas. The pressure control approach for variable speed driven (VSD parallel connected centrifugal pumps is reported. The goal of the study is optimization of some quality indices, such as efficiency, consumed power, productivity, energy carrier temperature, heat irradiation, etc. One of them – efficiency – has been studied in the paper more carefully. The mathematical model of pumping process is discussed and a vector-matrix description of the multi-pump application is given. The program-based pressure control system is developed which productivity is changed by regulating the number of working pumps. The paper introduces new pressure control algorithms based on the working point estimation intended for programmable logical controllers (PLC. Experiments prove correctness of the offered methodology.

Differential white cell count by centrifugal microfluidics.

Energy Technology Data Exchange (ETDEWEB)

Sommer, Gregory Jon; Tentori, Augusto M.; Schaff, Ulrich Y.

2010-07-01

We present a method for counting white blood cells that is uniquely compatible with centrifugation based microfluidics. Blood is deposited on top of one or more layers of density media within a microfluidic disk. Spinning the disk causes the cell populations within whole blood to settle through the media, reaching an equilibrium based on the density of each cell type. Separation and fluorescence measurement of cell types stained with a DNA dye is demonstrated using this technique. The integrated signal from bands of fluorescent microspheres is shown to be proportional to their initial concentration in suspension. Among the current generation of medical diagnostics are devices based on the principle of centrifuging a CD sized disk functionalized with microfluidics. These portable 'lab on a disk' devices are capable of conducting multiple assays directly from a blood sample, embodied by platforms developed by Gyros, Samsung, and Abaxis. [1,2] However, no centrifugal platform to date includes a differential white blood cell count, which is an important metric complimentary to diagnostic assays. Measuring the differential white blood cell count (the relative fraction of granulocytes, lymphocytes, and monocytes) is a standard medical diagnostic technique useful for identifying sepsis, leukemia, AIDS, radiation exposure, and a host of other conditions that affect the immune system. Several methods exist for measuring the relative white blood cell count including flow cytometry, electrical impedance, and visual identification from a stained drop of blood under a microscope. However, none of these methods is easily incorporated into a centrifugal microfluidic diagnostic platform.

Designing and modeling a centrifugal microfluidic device to separate target blood cells

Science.gov (United States)

Shamloo, Amir; Selahi, AmirAli; Madadelahi, Masoud

2016-03-01

The objective of this study is to design a novel and efficient portable lab-on-a-CD (LOCD) microfluidic device for separation of specific cells (target cells) using magnetic beads. In this study the results are shown for neutrophils as target cells. However, other kinds of target cells can be separated in a similar approach. The designed microfluidics can be utilized as a point of care system for neutrophil detection. This microfluidic system employs centrifugal and magnetic forces for separation. After model validation by the experimental data in the literature (that may be used as a design tool for developing centrifugo-magnetophoretic devices), two models are presented for separation of target cells using magnetic beads. The first model consists of one container in the inlet section and two containers in the outlets. Initially, the inlet container is filled with diluted blood sample which is a mixture of red blood cells (RBCs) plus neutrophils which are attached to Magnetic beads. It is shown that by using centrifugal and magnetic forces, this model can separate all neutrophils with recovery factor of ~100%. In the second model, due to excess of magnetic beads in usual experimental analysis (to ensure that all target cells are attached to them) the geometry is improved by adding a third outlet for these free magnetic beads. It is shown that at angular velocity of 45 rad s-1, recovery factor of 100% is achievable for RBCs, free magnetic beads and neutrophils as target cells.

Centrifugal microfluidic platforms: advanced unit operations and applications.

Science.gov (United States)

Strohmeier, O; Keller, M; Schwemmer, F; Zehnle, S; Mark, D; von Stetten, F; Zengerle, R; Paust, N

2015-10-07

Centrifugal microfluidics has evolved into a mature technology. Several major diagnostic companies either have products on the market or are currently evaluating centrifugal microfluidics for product development. The fields of application are widespread and include clinical chemistry, immunodiagnostics and protein analysis, cell handling, molecular diagnostics, as well as food, water, and soil analysis. Nevertheless, new fluidic functions and applications that expand the possibilities of centrifugal microfluidics are being introduced at a high pace. In this review, we first present an up-to-date comprehensive overview of centrifugal microfluidic unit operations. Then, we introduce the term "process chain" to review how these unit operations can be combined for the automation of laboratory workflows. Such aggregation of basic functionalities enables efficient fluidic design at a higher level of integration. Furthermore, we analyze how novel, ground-breaking unit operations may foster the integration of more complex applications. Among these are the storage of pneumatic energy to realize complex switching sequences or to pump liquids radially inward, as well as the complete pre-storage and release of reagents. In this context, centrifugal microfluidics provides major advantages over other microfluidic actuation principles: the pulse-free inertial liquid propulsion provided by centrifugal microfluidics allows for closed fluidic systems that are free of any interfaces to external pumps. Processed volumes are easily scalable from nanoliters to milliliters. Volume forces can be adjusted by rotation and thus, even for very small volumes, surface forces may easily be overcome in the centrifugal gravity field which enables the efficient separation of nanoliter volumes from channels, chambers or sensor matrixes as well as the removal of any disturbing bubbles. In summary, centrifugal microfluidics takes advantage of a comprehensive set of fluidic unit operations such as

Laboratory evaluation of the emulsifying characteristics of pumps

Energy Technology Data Exchange (ETDEWEB)

Harvey, A.C.; Guzdar, A.R.; Friswell, D.R.

1973-10-01

The program was devoted to a laboratory investigation of the emulsifying characteristics of different pumps suitable for shipboard pumping of bilge and ballast water oily wastes. The tests were designed to investigate the effect of several parameters, such as oil type, input oil concentration, detergent, pump operating characteristics (pressure and flow rate), and salt vs. fresh water, on emulsification. Tests were conducted on the Foster-Miller test loop. No. 2 fuel oil, lubricating oil and No. 6 fuel oil were the oils tested at concentrations ranging from 1 to 10%. The oils were tested with and without the addition of 10% Gamlen D surfactant. The pumps used were a Parker Diaphragm pump, a Blackmer Sliding Vane pump, an Ingersoll Rand Centrifugal pump, and a Deming Centrifugal pump. Pump pressure ranged from 10 to 60 psi and flow rates from 10 to 100 gpm. A total of 270 tests was conducted covering 198 different operating points, 108 concerning pump comparison, 54 concerning oil concentration and surfactant, and 45 concerning salt water.

Artificial heart system thermal converter and blood pump component research and development

International Nuclear Information System (INIS)

Pouchot, W.D.; Bifano, N.J.; Hanson, J.P.

1975-01-01

A bench model version of a nuclear-powered artificial heart system to be used as a replacement for the natural heart was constructed and tested as a part of a broader U. S. ERDA program. The objective of the broader program has been to develop a prototype of a fully implantable nuclear-powered total artificial heart system powered by the thermal energy of plutonium-238 and having minimum weight and volume and a minimum life of ten years. As a forward step in this broader program, component research and development has been carried out directed towards a fully implantable and advanced version of the bench model (IVBM). Some of the results of the component research and development effort on a Stirling engine, blood pump drive mechanisms, and coupling mechanisms are presented. The Stirling-mechanical system under development is shown. There are three major subassemblies: the thermal converter, the coupling mechanism, and the blood pump drive mechanism. The thermal converter uses a Stirling cycle to convert the heat of the plutonium-238 fueled heat source to a rotary shaft power output. The coupling mechanism changes the orientation of the output shaft by 90 degrees and transmits the pumping power by wire-wound core flexible shafting to the pumping mechanism. The coupling mechanism also provides routing of the coolant lines which carry the cycle waste heat from the thermal converter to the blood pump. The change in orientation of the thermal converter output shaft is for convenience in implanting in a calf. This orientation of thermal converter to blood pump seemed to give the best overall system fit in a calf based on fit trials with wooden models in a calf cadaver

Haemolysis following rapid experimental red blood cell transfusion--an evaluation of two infusion pumps

DEFF Research Database (Denmark)

Hansen, Tom Giedsing; Sprogøe-Jakobsen, U; Pedersen, C M

1998-01-01

The vast majority of infusion pumps used for rapid transfusion of large amounts of blood have never been properly examined regarding their influence on the quality of the red blood cells (RBCs) infused. In this study, we evaluated the effect of two different infusion pumps on the degree of RBC...

Influence of centrifugation conditions on the results of 77 routine clinical chemistry analytes using standard vacuum blood collection tubes and the new BD-Barricor tubes.

Science.gov (United States)

Cadamuro, Janne; Mrazek, Cornelia; Leichtle, Alexander B; Kipman, Ulrike; Felder, Thomas K; Wiedemann, Helmut; Oberkofler, Hannes; Fiedler, Georg M; Haschke-Becher, Elisabeth

2018-02-15

Although centrifugation is performed in almost every blood sample, recommendations on duration and g-force are heterogeneous and mostly based on expert opinions. In order to unify this step in a fully automated laboratory, we aimed to evaluate different centrifugation settings and their influence on the results of routine clinical chemistry analytes. We collected blood from 41 healthy volunteers into BD Vacutainer PST II-heparin-gel- (LiHepGel), BD Vacutainer SST II-serum-, and BD Vacutainer Barricor heparin-tubes with a mechanical separator (LiHepBar). Tubes were centrifuged at 2000xg for 10 minutes and 3000xg for 7 and 5 minutes, respectively. Subsequently 60 and 21 clinical chemistry analytes were measured in plasma and serum samples, respectively, using a Roche COBAS instrument. High sensitive Troponin T, pregnancy-associated plasma protein A, ß human chorionic gonadotropin and rheumatoid factor had to be excluded from statistical evaluation as many of the respective results were below the measuring range. Except of free haemoglobin (fHb) measurements, no analyte result was altered by the use of shorter centrifugation times at higher g-forces. Comparing LiHepBar to LiHepGel tubes at different centrifugation setting, we found higher lactate-dehydrogenase (LD) (P = 0.003 to centrifuged at higher speed (3000xg) for a shorter amount of time (5 minutes) without alteration of the analytes tested in this study. When using LiHepBar tubes for blood collection, a separate LD reference value might be needed.

Application of a compressible flow solver and barotropic cavitation model for the evaluation of the suction head in a low specific speed centrifugal pump impeller channel

International Nuclear Information System (INIS)

Limbach, P; Müller, T; Skoda, R

2015-01-01

Commonly, for the simulation of cavitation in centrifugal pumps incompressible flow solvers with VOF kind cavitation models are applied. Since the source/sink terms of the void fraction transport equation are based on simplified bubble dynamics, empirical parameters may need to be adjusted to the particular pump operating point. In the present study a barotropic cavitation model, which is based solely on thermodynamic fluid properties and does not include any empirical parameters, is applied on a single flow channel of a pump impeller in combination with a time-explicit viscous compressible flow solver. The suction head curves (head drop) are compared to the results of an incompressible implicit standard industrial CFD tool and are predicted qualitatively correct by the barotropic model. (paper)

Use of short-radius centrifugation to augment ankle-brachial indices.

Science.gov (United States)

Grenon, S Marlene; Mateus, Jaime; Hsiang, York; Sidhu, Ravi; Young, Laurence; Gagnon, Joel

2009-06-01

Peripheral arterial disease is mainly caused by atherosclerosis and is characterized by decreased circulation, lower blood pressure, and insufficient tissue perfusion in the lower extremities. The hemodynamics of standing and altered gravity environments have been well studied relative to arm blood pressures but are less well understood for ankle pressures. Because regional blood pressure depends, in part, on the gravitational pressure gradient, we hypothesized that artificial gravity exposure on a short-arm centrifuge with the center of rotation above the head would increase blood pressure in the lower extremities. Cardiovascular parameters for 12 healthy subjects were measured during exposure to supine short-arm centrifugation at 20, 25, and 30 revolutions per minute (rpm), corresponding to centripetal accelerations of 0.94, 1.47, and 2.11 Gz at the foot level, respectively. Systolic ankle blood pressure significantly increased at all levels of centrifugation. Ankle-brachial indices (the ratio of systolic ankle to arm blood pressures) increased significantly from 1.17 +/- 0.03 to 1.58 +/- 0.03 at 0.94 Gz (P blood pressure significantly increased at 2.11 Gz, but heart rate did not change significantly. All parameters returned to normal after cessation of centrifugation. We demonstrated that short-radius centrifugation leads to an increase in ankle-brachial indices. This could have potential implications for the treatment of peripheral arterial disease.

Effect of hydrodynamic action in peristaltic pump of blood gases analyzer ABL 555

Directory of Open Access Journals (Sweden)

Ali K. Mohammed

2018-01-01

Full Text Available In this research, we studied the effect of hydrodynamic action in peristaltic pump of blood gases analyzer ABL 555 which made by (Radiometer-Copenhagen, by using theories of tribology and Reynolds equation on performance of blood film convergence area, we analyzing the influence of theoretical model for peristaltic pump (consist of steeper motor and 4 cylindrical bearings distributed on circular disc rotating around capillary tube, by using (MATLAB R 2012b programing with numerical solution of finite difference method in 5 nodes element , we fined the blood film thickness and the pressure on contact area grid ( consist from annual and axial lines , then influence of viscosity of blood on pressure generated in limited temperature of ambient and velocity of motor , and flow rate of blood in tube. The important conclusions appear that the rotating sliding movement of motor cause low pressure (positive while the rolling cylindrical rollers of bearings cause high pressure (negative which lead to push the blood in tube, that mean the direction of rotating blood opposite the direction of rotating motor of peristaltic pump, also the viscosity of blood effect on velocity of flow and the speed of motor with bearings, and the effect of blood film thickness effect on pressure generated in tube. DOI: http://dx.doi.org/10.25130/tjes.24.2017.18

A novel high efficiency solar photovoltalic pump

NARCIS (Netherlands)

Diepens, J.F.L.; Smulders, P.T.; Vries, de D.A.

1993-01-01

The daily average overall efficiency of a solar pump system is not only influenced by the maximum efficiency of the components of the system, but just as much by the correct matching of the components to the local irradiation pattern. Normally centrifugal pumps are used in solar pump systems. The

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation.

Science.gov (United States)

Rim, Yeri Alice; Nam, Yoojun; Ju, Ji Hyeon

2016-12-21

The recent development of human induced pluripotent stem cells (hiPSCs) proved that mature somatic cells can return to an undifferentiated, pluripotent state. Now, reprogramming is done with various types of adult somatic cells: keratinocytes, urine cells, fibroblasts, etc. Early experiments were usually done with dermal fibroblasts. However, this required an invasive surgical procedure to obtain fibroblasts from the patients. Therefore, suspension cells, such as blood and urine cells, were considered ideal for reprogramming because of the convenience of obtaining the primary cells. Here, we report an efficient protocol for iPSC generation from peripheral blood mononuclear cells (PBMCs). By plating the transduced PBMCs serially to a new, matrix-coated plate using centrifugation, this protocol can easily provide iPSC colonies. This method is also applicable to umbilical cord blood mononuclear cells (CBMCs). This study presents a simple and efficient protocol for the reprogramming of PBMCs and CBMCs.

Impact of age and diagnosis on viability during centrifugation and cryopreservation of peripheral blood stem cell products.

Science.gov (United States)

Civriz Bozdag, S; Bay, M; Ayyıldız, E; Topcuoglu, P; Ilhan, O

2012-08-01

The viability of the hematopoietic stem cells infused to the patient is important for transplant outcome. We evaluated 31 peripheral blood stem cell product collected from 15 patients. We aimed to check the viabilities of the cells from patients with different age and diagnosis, in different stages of the cryopreservation procedure. We showed a markedly decreased viability rate after centrifugation and addition of DMSO. Percentages of viabilities were similar between young and old patients in each step. Type of hematological malignancy did not make a significant influence on the viability. High speed centrifugation has a negative impact on the viability. Copyright © 2012 Elsevier Ltd. All rights reserved.

Designing and modeling a centrifugal microfluidic device to separate target blood cells

International Nuclear Information System (INIS)

Shamloo, Amir; Selahi, AmirAli; Madadelahi, Masoud

2016-01-01

The objective of this study is to design a novel and efficient portable lab-on-a-CD (LOCD) microfluidic device for separation of specific cells (target cells) using magnetic beads. In this study the results are shown for neutrophils as target cells. However, other kinds of target cells can be separated in a similar approach. The designed microfluidics can be utilized as a point of care system for neutrophil detection. This microfluidic system employs centrifugal and magnetic forces for separation. After model validation by the experimental data in the literature (that may be used as a design tool for developing centrifugo-magnetophoretic devices), two models are presented for separation of target cells using magnetic beads. The first model consists of one container in the inlet section and two containers in the outlets. Initially, the inlet container is filled with diluted blood sample which is a mixture of red blood cells (RBCs) plus neutrophils which are attached to Magnetic beads. It is shown that by using centrifugal and magnetic forces, this model can separate all neutrophils with recovery factor of ∼100%. In the second model, due to excess of magnetic beads in usual experimental analysis (to ensure that all target cells are attached to them) the geometry is improved by adding a third outlet for these free magnetic beads. It is shown that at angular velocity of 45 rad s −1 , recovery factor of 100% is achievable for RBCs, free magnetic beads and neutrophils as target cells. (paper)

A microfluidic timer for timed valving and pumping in centrifugal microfluidics.

Science.gov (United States)

Schwemmer, F; Zehnle, S; Mark, D; von Stetten, F; Zengerle, R; Paust, N

2015-03-21

Accurate timing of microfluidic operations is essential for the automation of complex laboratory workflows, in particular for the supply of sample and reagents. Here we present a new unit operation for timed valving and pumping in centrifugal microfluidics. It is based on temporary storage of pneumatic energy and time delayed sudden release of said energy. The timer is loaded at a relatively higher spinning frequency. The countdown is started by reducing to a relatively lower release frequency, at which the timer is released after a pre-defined delay time. We demonstrate timing for 1) the sequential release of 4 liquids at times of 2.7 s ± 0.2 s, 14.0 s ± 0.5 s, 43.4 s ± 1.0 s and 133.8 s ± 2.3 s, 2) timed valving of typical assay reagents (contact angles 36-78°, viscosities 0.9-5.6 mPa s) and 3) on demand valving of liquids from 4 inlet chambers in any user defined sequence controlled by the spinning protocol. The microfluidic timer is compatible to all wetting properties and viscosities of common assay reagents and does neither require assistive equipment, nor coatings. It can be monolithically integrated into a microfluidic test carrier and is compatible to scalable fabrication technologies such as thermoforming or injection molding.

Density-Gradient Mediated Band Extraction of Leukocytes from Whole Blood Using Centrifugo-Pneumatic Siphon Valving on Centrifugal Microfluidic Discs

Science.gov (United States)

Kearney, Sinéad M.; Kilcawley, Niamh A.; Early, Philip L.; Glynn, Macdara T.; Ducrée, Jens

2016-01-01

Here we present retrieval of Peripheral Blood Mononuclear Cells by density-gradient medium based centrifugation for subsequent analysis of the leukocytes on an integrated microfluidic “Lab-on-a-Disc” cartridge. Isolation of white blood cells constitutes a critical sample preparation step for many bioassays. Centrifugo-pneumatic siphon valves are particularly suited for blood processing as they function without need of surface treatment and are ‘low-pass’, i.e., holding at high centrifugation speeds and opening upon reduction of the spin rate. Both ‘hydrostatically’ and ‘hydrodynamically’ triggered centrifugo-pneumatic siphon valving schemes are presented. Firstly, the geometry of the pneumatic chamber of hydrostatically primed centrifugo-pneumatic siphon valves is optimised to enable smooth and uniform layering of blood on top of the density-gradient medium; this feature proves to be key for efficient Peripheral Blood Mononuclear Cell extraction. A theoretical analysis of hydrostatically primed valves is also presented which determines the optimum priming pressure for the individual valves. Next, ‘dual siphon’ configurations for both hydrostatically and hydrodynamically primed centrifugo-pneumatic siphon valves are introduced; here plasma and Peripheral Blood Mononuclear Cells are extracted through a distinct siphon valve. This work represents a first step towards enabling on disc multi-parameter analysis. Finally, the efficiency of Peripheral Blood Mononuclear Cells extraction in these structures is characterised using a simplified design. A microfluidic mechanism, which we termed phase switching, is identified which affects the efficiency of Peripheral Blood Mononuclear Cell extraction. PMID:27167376

A Turbidity Test Based Centrifugal Microfluidics Diagnostic System for Simultaneous Detection of HBV, HCV, and CMV

Directory of Open Access Journals (Sweden)

Hung-Cheng Chang

2015-01-01

Full Text Available This paper presents a LAMP- (loop-mediated isothermal amplification- based lab-on-disk optical system that allows the simultaneous detection of hepatitis B virus, hepatitis C virus, and cytomegalovirus. The various flow stages are controlled in the proposed system using different balance among centrifugal pumping, Coriolis pumping, and the capillary force. We have implemented a servo system for positioning and speed control for the heating and centrifugal pumping. We have also successfully employed a polymer light-emitting diode section for turbidity detection. The easy-to-use one-click system can perform diagnostics in less than 1 hour.

Distinct alterations in sublingual microcirculatory blood flow and hemoglobin oxygenation in on-pump and off-pump coronary artery bypass graft surgery

NARCIS (Netherlands)

Atasever, Bektaş; Boer, Christa; Goedhart, Peter; Biervliet, Jules; Seyffert, Jan; Speekenbrink, Ron; Schwarte, Lothar; de Mol, Bas; Ince, Can

2011-01-01

The authors hypothesized that cardiopulmonary bypass (CPB) (on-pump) is associated with more severe changes in the microcirculatory blood flow and tissue oxygenation as compared with off-pump coronary artery bypass surgery. An observational study. A university hospital and teaching hospital.

Long-term animal experiments with an intraventricular axial flow blood pump.

Science.gov (United States)

Yamazaki, K; Kormos, R L; Litwak, P; Tagusari, O; Mori, T; Antaki, J F; Kameneva, M; Watach, M; Gordon, L; Mukuo, H; Umezu, M; Tomioka, J; Outa, E; Griffith, B P; Koyanagai, H

1997-01-01

A miniature intraventricular axial flow blood pump (IVAP) is undergoing in vivo evaluation in calves. The IVAP system consists of a miniature (phi 13.9 mm) axial flow pump that resides within the left ventricular (LV) chamber and a brushless DC motor. The pump is fabricated from titanium alloy, and the pump weight is 170 g. It produces a flow rate of over 5 L/min against 100 mmHg pressure at 9,000 rpm with an 8 W total power consumption. The maximum total efficiency exceeds 17%. A purged lip seal system is used in prototype no. 8, and a newly developed "Cool-Seal" (a low temperature mechanical seal) is used in prototype no. 9. In the Cool-Seal system, a large amount of purge flow is introduced behind the seal faces to augment convective heat transfer, keeping the seal face temperature at a low level for prevention of heat denaturation of blood proteins. The Cool-Seal system consumes < 10 cc purge fluid per day and has greatly extended seal life. The pumps were implanted in three calves (26, 30, and 168 days of support). The pump was inserted through a left thoracotomy at the fifth intercostal space. Two pursestring sutures were placed on the LV apex, and the apex was cored with a myocardial punch. The pump was inserted into the LV with the outlet cannula smoothly passing through the aortic valve without any difficulty. Only 5 min elapsed between the time of chest opening and initiation of pumping. Pump function remained stable throughout in all experiments. No cardiac arrhythmias were detected, even at treadmill exercise tests. The plasma free hemoglobin level remained in the acceptable range. Post mortem examination did not reveal any interference between the pump and the mitral apparatus. No major thromboembolism was detected in the vital organs in Cases 1 or 2, but a few small renal infarcts were detected in Case 3.

Optimisation of a double-centrifugation method for preparation of canine platelet-rich plasma.

Science.gov (United States)

Shin, Hyeok-Soo; Woo, Heung-Myong; Kang, Byung-Jae

2017-06-26

Platelet-rich plasma (PRP) has been expected for regenerative medicine because of its growth factors. However, there is considerable variability in the recovery and yield of platelets and the concentration of growth factors in PRP preparations. The aim of this study was to identify optimal relative centrifugal force and spin time for the preparation of PRP from canine blood using a double-centrifugation tube method. Whole blood samples were collected in citrate blood collection tubes from 12 healthy beagles. For the first centrifugation step, 10 different run conditions were compared to determine which condition produced optimal recovery of platelets. Once the optimal condition was identified, platelet-containing plasma prepared using that condition was subjected to a second centrifugation to pellet platelets. For the second centrifugation, 12 different run conditions were compared to identify the centrifugal force and spin time to produce maximal pellet recovery and concentration increase. Growth factor levels were estimated by using ELISA to measure platelet-derived growth factor-BB (PDGF-BB) concentrations in optimised CaCl 2 -activated platelet fractions. The highest platelet recovery rate and yield were obtained by first centrifuging whole blood at 1000 g for 5 min and then centrifuging the recovered platelet-enriched plasma at 1500 g for 15 min. This protocol recovered 80% of platelets from whole blood and increased platelet concentration six-fold and produced the highest concentration of PDGF-BB in activated fractions. We have described an optimised double-centrifugation tube method for the preparation of PRP from canine blood. This optimised method does not require particularly expensive equipment or high technical ability and can readily be carried out in a veterinary clinical setting.

Power Consumption Optimization for Multiple Parallel Centrifugal Pumps

DEFF Research Database (Denmark)

Jepsen, Kasper Lund; Hansen, Leif; Mai, Christian

2017-01-01

Large amounts of energy is being used in a wide range of applications to transport liquid. This paper proposes a generic solution for minimizing power consumption of a generic pumping station equipped with identical variable speed pumps. The proposed solution consists of two sequential steps; fir...

Investigation on transient flow of a centrifugal charging pump in the process of high pressure safety injection

Energy Technology Data Exchange (ETDEWEB)

Zhang, Fan, E-mail: zhangfan4060@gmail.com; Yuan, Shouqi; Fu, Qiang; Tao, Yi

2015-11-15

Highlights: • The transient flow characteristics of the charging pump with the first stage impeller in the HPSI process have been investigated numerically by CFD. • The hydraulic performance of the charging pump during the HPSI are discussed, andthe absolute errors between the simulated and measured results are analyzed in the paper. • Pressure fluctuation in the impeller and flow pattern in the impeller were studied in the HPSI process. It is influenced little at the beginning of the HPSI process while fluctuates strongly in the end of the HPSI process. - Abstract: In order to investigate the transient flow characteristics of the centrifugal charging pump during the transient transition process of high pressure safety injection (HPSI) from Q = 148 m{sup 3}/h to Q = 160 m{sup 3}/h, numerical simulation and experiment are implemented in this study. The transient flow rate, which is the most important factor, is obtained from the experiment and works as the boundary condition to accurately accomplish the numerical simulation in the transient process. Internal characteristics under the variable operating conditions are analyzed through the transient simulation. The results shows that the absolute error between the simulated and measured heads is less than 2.26% and the absolute error between the simulated and measured efficiency is less than 2.04%. Pressure fluctuation in the impeller is less influenced by variable flow rate in the HPSI process, while flow pattern in the impeller is getting better and better with the flow rate increasing. As flow rate increases, fluid blocks on the tongue of the volute and it strikes in this area at large flow rate. Correspondingly, the pressure fluctuation is intense and vortex occurs gradually during this period, which obviously lowers the efficiency of the pump. The contents of the current work can provide references for the design optimization and fluid control of the pump used in the transient process of variable operating

Investigation on transient flow of a centrifugal charging pump in the process of high pressure safety injection

International Nuclear Information System (INIS)

Zhang, Fan; Yuan, Shouqi; Fu, Qiang; Tao, Yi

2015-01-01

Highlights: • The transient flow characteristics of the charging pump with the first stage impeller in the HPSI process have been investigated numerically by CFD. • The hydraulic performance of the charging pump during the HPSI are discussed, andthe absolute errors between the simulated and measured results are analyzed in the paper. • Pressure fluctuation in the impeller and flow pattern in the impeller were studied in the HPSI process. It is influenced little at the beginning of the HPSI process while fluctuates strongly in the end of the HPSI process. - Abstract: In order to investigate the transient flow characteristics of the centrifugal charging pump during the transient transition process of high pressure safety injection (HPSI) from Q = 148 m"3/h to Q = 160 m"3/h, numerical simulation and experiment are implemented in this study. The transient flow rate, which is the most important factor, is obtained from the experiment and works as the boundary condition to accurately accomplish the numerical simulation in the transient process. Internal characteristics under the variable operating conditions are analyzed through the transient simulation. The results shows that the absolute error between the simulated and measured heads is less than 2.26% and the absolute error between the simulated and measured efficiency is less than 2.04%. Pressure fluctuation in the impeller is less influenced by variable flow rate in the HPSI process, while flow pattern in the impeller is getting better and better with the flow rate increasing. As flow rate increases, fluid blocks on the tongue of the volute and it strikes in this area at large flow rate. Correspondingly, the pressure fluctuation is intense and vortex occurs gradually during this period, which obviously lowers the efficiency of the pump. The contents of the current work can provide references for the design optimization and fluid control of the pump used in the transient process of variable operating conditions.

Fluid-structure coupling effects on periodically transient flow of a single-blade sewage centrifugal pump

International Nuclear Information System (INIS)

Pei, Ji; Yuan, Shouqi; Yuan, Jianping

2013-01-01

A partitioned fluid-structure interaction (FSI) solving strategy that depends on problem characteristics is applied to quantitatively obtain the coupling effects of a fluid-structure system in a single-blade centrifugal pump on the unsteady flow. A two-way coupling method is employed to realize strong FSI effects in the calculation procedure. The successful impeller oscillation measurement using two proximity sensors validated the FSI simulation accuracy in a complicated and practical fluid-structure system having a rotating component. The results show that the hydrodynamic force deviation can be observed in the results for the coupled versus uncoupled cases. Additionally, the coupled unsteady pressure is larger than the uncoupled value for every monitoring point at every impeller rotation position. Comparison results for different monitoring points under an overload condition and partial-load condition display the same regularities. To some extent, this interaction mechanism would affect the accuracy and reliability of the unsteady flow and rotor deflection analysis.

Comparison of the Lysis Centrifugation Method with the Conventional Blood Culture Method in Cases of Sepsis in a Tertiary Care Hospital

OpenAIRE

Parikh, Harshal R; De, Anuradha S; Baveja, Sujata M

2012-01-01

Introduction : Physicians and microbiologists have long recognized that the presence of living microorganisms in the blood of a patient carries with it considerable morbidity and mortality. Hence, blood cultures have become critically important and frequently performed test in clinical microbiology laboratories for diagnosis of sepsis. Objectives: To compare the conventional blood culture method with the lysis centrifugation method in cases of sepsis. Materials and Methods: Two hundred ...

LH2 pump component development testing in the electric pump room at test cell C inducer no. 1

Science.gov (United States)

Andrews, F. X.; Brunner, J. J.; Kirk, K. G.; Mathews, J. P.; Nishioka, T.

1972-01-01

The characteristics of a turbine pump for use with the nuclear engine for rocket vehicles are discussed. It was determined that the pump will be a two stage centrifugal pump with both stages having backswept impellers and an inducer upstream of the first stage impeller. The test program provided demonstration of the ability of the selected design to meet the imposed requirements.

A durable, non power consumptive, simple seal for rotary blood pumps.

Science.gov (United States)

Mitamura, Y; Sekine, K; Asakawa, M; Yozu, R; Kawada, S; Okamoto, E

2001-01-01

One of the key technologic requirements for rotary blood pumps is the sealing of the motor shaft. A mechanical seal, a journal bearing, magnetic coupling, and magnetic suspension have been developed, but they have drawbacks such as wear, thrombus formation, and power consumption. A magnetic fluid seal was developed for an axial flow pump. A magnetic fluid seal is durable, simple, and non power consumptive. Long-term experiments and finite element modeling (FEM) analyses confirmed these advantages. The seal body was composed of a Ned-Fe magnet and two pole pieces; the seal was formed by injecting ferrofluid into the gap (50 microm) between the pole pieces and the motor shaft. To contain the ferrofluid in the seal and to minimize the possibility of ferrofluid making contact with blood, a shield with a small cavity was attached to the pole piece. While submerged in blood, the sealing pressure of the seal was measured and found to be 188 mm Hg with ferrofluid LS-40 (saturated magnetization, 24.3 kA/m) at a motor speed of 10,000 rpm and 225 mm Hg under static conditions. The magnetic fluid seals performed perfectly at a pressure of 100 mm Hg for 594 + days in a static condition, and 51, 39+, and 34+ days at a motor speed of 8,000 rpm. FEM analyses indicated a theoretical sealing pressure of 260 mm Hg. The state of the magnetic fluid in the seal in water was observed with a microscope. Neither splashing of magnetic fluid nor mixing of the magnetic fluid and water was observed. The specially designed magnetic fluid seal for keeping liquids out is useful for axial flow blood pumps. The magnetic fluid seal was incorporated into an intracardiac axial flow pump.

Part-load pumping operation, control and behaviour

International Nuclear Information System (INIS)

1988-01-01

Twenty one papers are printed. Their main concern is with pump performance under abnormal operating conditions or when operating at part-load. The effect of part-load operation on pump performance, pump internal flow and pump cavitation and noise were considered. The pumps considered are used in a variety of situations and some case studies were discussed. One paper about part-load operation of the boiler pumps for French pressurized water reactors and one paper on pressure pulsations of centrifugal pumps at very low flowrate, are indexed separately. (U.K.)

Flow Simulation and Performance Prediction of Centrifugal Pumps ...

African Journals Online (AJOL)

With the aid of computational fluid dynamics, the complex internal flows in water pump impellers can be well predicted, thus facilitating the product development process of pumps. In this paper a commercial CFD code was used to solve the governing equations of the flow field. A 2-D simulation of turbulent fluid flow is ...

PIV Investigations of the Flow Field in the Volute of a Rotary Blood Pump

Science.gov (United States)

Sankovic, John M.; Kadambi, Jaikrishnan R.; Smith, William A.; Wernet, Mark P.

2004-01-01

A full-size acrylic model of a rotary blood pump was developed in order to utilize Particle Image Velocimetry (PIV) to make measurements of the fluid velocities and turbulent stresses throughout the device. The development of an understanding of the hemodynamics within the blood pump is critical to the development and validation of computational models. A blood analog solution, consisting of sodium iodide solution and glycerin, was developed to match physiological kinematic viscosity. The refractive indices of the fluid, the pump casing, and the impeller were matched to facilitate the use of PIV to make velocity measurements. Velocity measurements made in the volute exit/diffuser region are presented for pumps speeds of 3000-3850 rpm. At each speed data were obtained at a physiological pressure of 12 kPa and at a maximum flow condition. Four hundred data pairs were used for each resultant mean velocity vector value, representing greater than an order of magnitude more data pairs than reported previously in the literature on similar devices and resulting in velocity uncertainty levels of approximately 22.9%.

Effects of preoperative aspirin and clopidogrel therapy on perioperative blood loss and blood transfusion requirements in patients undergoing off-pump coronary artery bypass graft surgery.

Science.gov (United States)

Shim, Jae Kwang; Choi, Yong Seon; Oh, Young Jun; Bang, Sou Ouk; Yoo, Kyung Jong; Kwak, Young Lan

2007-07-01

Preoperative exposure to clopidogrel and aspirin significantly increases postoperative bleeding in patients undergoing on-pump coronary artery bypass graft surgery. Off-pump coronary bypass grafting has been proposed as an alternative technique to attenuate postoperative bleeding associated with clopidogrel. This study aimed to determine the effects of aspirin and clopidogrel therapy on perioperative blood loss and blood transfusion requirements in off-pump coronary artery bypass grafting. One hundred six patients scheduled for off-pump coronary artery bypass grafting were divided into three groups: aspirin and clopidogrel discontinued more than 6 days before surgery (group 1, n = 35), aspirin and clopidogrel continued until 3 to 5 days before surgery (group 2, n = 51), and both medications continued within 2 days of surgery (group 3, n = 20). Thromboelastographic tracings were analyzed before induction of anesthesia. Routine coagulation profiles were measured before and after surgery. A cell salvage device was used during surgery and salvaged blood was reinfused. Chest tube drainage and blood transfusion requirement were recorded postoperatively. Patient characteristics, operative data, and thromboelastographic tracings were similar among the groups. There were significant decreases in hematocrit level and platelet count and prolongation in prothrombin time postoperatively in all groups without any intergroup differences. The amounts of perioperative blood loss and blood transfusion required were all similar among the groups. Preoperative clopidogrel and aspirin exposure even within 2 days of surgery does not increase perioperative blood loss and blood transfusion requirements in patients undergoing elective off-pump coronary artery bypass grafting.

Annual technical progress report inducer pump program government fiscal year 1976 and 1976T

International Nuclear Information System (INIS)

1976-01-01

The Inducer Pump Program was initiated to demonstrate the applicability and advantages of an inducer pump to the LMFBR. The inducer is a pump blading which is specifically tailored to provide excellent suction performance. Operating suction specific speeds two to three times those for the inlet of a centrifugal impeller can be achieved with a properly and conservatively designed inducer. When coupled to a centrifugal impeller, the inducer offers excellent suction performance which can be effectively used to optimize pump efficiency, reduce pump size, and reduce pump cost. Four major efforts were undertaken during the five quarters of GFY 1976 to demonstrate and verify the inducer's suitability and applicability to LMFBR pumps, and to quantify the advantages of the inducer pump. The efforts are summarized

40 CFR 63.1035 - Quality improvement program for pumps.

Science.gov (United States)

2010-07-01

...., piston, horizontal or vertical centrifugal, gear, bellows); pump manufacturer; seal type and manufacturer... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Quality improvement program for pumps... improvement program for pumps. (a) Criteria. If, on a 6-month rolling average, at least the greater of either...

Spin doctors: new innovations for centrifugal apheresis.

Science.gov (United States)

Kambic, H E; Nosé, Y

1997-08-01

The preparation of plasma from blood has a long history dating back to the early 1900s when the concept of blood washing replaced the traditional blood letting. Over the next 57 years landmark discoveries such as centrifugal and membrane filtration systems led to different and rapid plasma, solute, and cell separation. These were not singular events but rather events influenced by the converging chemical, physiological, and engineering advances that have characterized the latter half of the 20th century. These events have led to entire new fields of biomedical research. The biotechnology for on-line plasma separation and plasma treatment has opened a new era, expanding the application of extracorporeal technology to modern therapeutic medicine. The association of biochemical or cellular abnormalities with various disease states provides the rationale for therapeutic plasma exchange (the removal of large amounts of patient's plasma, alone or with replacement with crystalloid) and therapeutic cytopheresis (removal of cellular elements). The purpose of this review is to provide a historical picture of the innovative ideas of the spin doctors and their devices, which predate the centrifugal blood and cell separators commonplace to any hospital or blood bank worldwide. The emphasis is to define the historical events and their impacts on the development of centrifugal devices and apheresis technologies.

Hemodynamics of a functional centrifugal-flow total artificial heart with functional atrial contraction in goats.

Science.gov (United States)

Shiga, Takuya; Shiraishi, Yasuyuki; Sano, Kyosuke; Taira, Yasunori; Tsuboko, Yusuke; Yamada, Akihiro; Miura, Hidekazu; Katahira, Shintaro; Akiyama, Masatoshi; Saiki, Yoshikatsu; Yambe, Tomoyuki

2016-03-01

Implantation of a total artificial heart (TAH) is one of the therapeutic options for the treatment of patients with end-stage biventricular heart failure. There is no report on the hemodynamics of the functional centrifugal-flow TAH with functional atrial contraction (fCFTAH). We evaluated the effects of pulsatile flow by atrial contraction in acute animal models. The goats received fCFTAH that we created from two centrifugal-flow ventricular assist devices. Some hemodynamic parameters maintained acceptable levels: heart rate 115.5 ± 26.3 bpm, aortic pressure 83.5 ± 10.1 mmHg, left atrial pressure 18.0 ± 5.9 mmHg, pulmonary pressure 28.5 ± 9.7 mmHg, right atrial pressure 13.6 ± 5.2 mmHg, pump flow 4.0 ± 1.1 L/min (left) 3.9 ± 1.1 L/min (right), and cardiac index 2.13 ± 0.14 L/min/m(2). fCFTAH with atrial contraction was able to maintain the TAH circulation by forming a pulsatile flow in acute animal experiments. Taking the left and right flow rate balance using the low internal pressure loss of the VAD pumps may be easier than by other pumps having considerable internal pressure loss. We showed that the remnant atrial contraction effected the flow rate change of the centrifugal pump, and the atrial contraction waves reflected the heart rate. These results indicate that remnant atria had the possibility to preserve autonomic function in fCFTAH. We may control fCFTAH by reflecting the autonomic function, which is estimated with the flow rate change of the centrifugal pump.

Condensate and feedwater systems, pumps, and water chemistry. Volume seven

International Nuclear Information System (INIS)

Anon.

1986-01-01

Subject matter includes condensate and feedwater systems (general features of condensate and feedwater systems, condenser hotwell level control, condensate flow, feedwater flow), pumps (principles of fluid flow, types of pumps, centrifugal pumps, positive displacement pumps, jet pumps, pump operating characteristics) and water chemistry (water chemistry fundamentals, corrosion, scaling, radiochemistry, water chemistry control processes, water pretreatment, PWR water chemistry, BWR water chemistry, condenser circulating water chemistry

40 CFR 63.176 - Quality improvement program for pumps.

Science.gov (United States)

2010-07-01

... type (e.g., piston, horizontal or vertical centrifugal, gear, bellows); pump manufacturer; seal type... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Quality improvement program for pumps... improvement program for pumps. (a) In Phase III, if, on a 6-month rolling average, the greater of either 10...

Large-scale clinical comparison of the lysis-centrifugation and radiometric systems for blood culture

International Nuclear Information System (INIS)

Brannon, P.; Kiehn, T.E.

1985-01-01

The Isolator 10 lysis-centrifugation blood culture system (E. I. du Pont de Nemours and Co., Inc., Wilmington, Del.) was compared with the BACTEC radiometric method (Johnston Laboratories, Inc., Towson, Md.) with 6B and 7D broth media for the recovery of bacteria and yeasts. From 11,000 blood cultures, 1,174 clinically significant organisms were isolated. The Isolator system recovered significantly more total organisms, members of the family Enterobacteriaceae, Staphylococcus spp., and yeasts. The BACTEC system recovered significantly more Pseudomonas spp., Streptococcus spp., and anaerobes. Of the Isolator colony counts, 87% measured less than 11 CFU/ml of blood. Organisms, on an average, were detected the same day from each of the two culture systems. Only 13 of the 975 BACTEC isolates (0.01%) were recovered by subculture of growth-index-negative bottles, and 12 of the 13 were detected in another broth blood culture taken within 24 h. Contaminants were recovered from 4.8% of the Isolator 10 and 2.3% of the BACTEC cultures

Centrifugal potential energy : an astounding renewable energy concept

Energy Technology Data Exchange (ETDEWEB)

Oduniyi, I.A. [Aled Conglomerate Nigeria Ltd., Lagos (Nigeria)

2010-07-01

A new energy concept known as centrifugal potential energy was discussed. This new energy concept is capable of increasing the pressure, temperature and enthalpy of a fluid, without having to apply work or heat transfer to the fluid. It occurs through a change in the centrifugal potential energy of the flowing fluid in a rotating frame of reference or a centrifugal force field, where work is performed internally by the centrifugal weight of the fluid. This energy concept has resulted in new energy equations, such as the Rotational Frame Bernoulli's Equation for liquids and the Rotational Frame Steady-Flow Energy Equation for gases. Applications of these equations have been incorporated into the design of centrifugal field pumps and compressors. Rather than compressing a fluid with a physical load transfer, these devices can compress a fluid via the effect of centrifugal force applied to the object. A large amount of energy is therefore produced when this high pressure compressed working fluid expands in a turbine. When water is used as the working fluid, it could reach renewable energy densities in the range of 25-100 kJ/kg of water. When atmospheric air is used, it could reach energy densities in the range of 500-1,500 kJ/kg of air.

Electromagnetic pump technology

International Nuclear Information System (INIS)

Prabhakar, R.

1994-01-01

Fast Breeder Reactors have an important role to play in our nuclear power programme. Liquid metal sodium is used as the coolant for removing fission heat generated in fast reactors and a distinctive physical property of sodium is its high electrical conductivity. This enables application of electromagnetic (EM) pumps, working on same principle as electric motors, for pumping liquid sodium. Due to its lower efficiency as compared to centrifugal pumps, use of EM pumps has been restricted to reactor auxiliary circuits and experimental facilities. As part of our efforts to manufacture fast reactor components indigenously, work on the development of two types of EM pumps namely flat linear induction pump (FLIP) and annular linear induction pump (ALIP) has been undertaken. Design procedures based on an equivalent circuit approach have been established and results from testing a 5.6 x 10E-3 Cum/s (20 Cum/h) FLIP in a sodium loop were used to validate the procedure. (author). 7 refs., 6 figs

Pumps for nuclear facilities

International Nuclear Information System (INIS)

1999-01-01

The guide describes how the Finnish Radiation and Nuclear Safety Authority (STUK) controls pumps and their motors at nuclear power plants and other nuclear facilities. The scope of the control is determined by the Safety Class of the pump in question. The various phases of the control are: (1) review of construction plan, (2) control of manufacturing, and construction inspection, (3) commissioning inspection, and (4) control during operation. STUK controls Safety Class 1, 2 and 3 pumps at nuclear facilities as described in this guide. STUK inspects Class EYT (non-nuclear) pumps separately or in connection with the commissioning inspections of the systems. This guide gives the control procedure and related requirements primarily for centrifugal pumps. However, it is also applied to the control of piston pumps and other pump types not mentioned in this guide

[A comparative study of blood culture conventional method vs. a modified lysis/centrifugation technique for the diagnosis of fungemias].

Science.gov (United States)

Santiago, Axel Rodolfo; Hernández, Betsy; Rodríguez, Marina; Romero, Hilda

2004-12-01

The purpose of this work was to compare the efficacy of blood culture conventional method vs. a modified lysis/centrifugation technique. Out of 450 blood specimens received in one year, 100 where chosen for this comparative study: 60 from patients with AIDS, 15 from leukemic patients, ten from febrile neutropenic patients, five from patients with respiratory infections, five from diabetics and five from septicemic patients. The specimens were processed, simultaneously, according to the above mentioned methodologies with daily inspections searching for fungal growth in order to obtain the final identification of the causative agent. The number (40) of isolates recovered was the same using both methods, which included; 18 Candida albicans (45%), ten Candida spp. (25%), ten Histoplasma capsulatum (25%), and two Cryptococcus neoformans (5%). When the fungal growth time was compared by both methods, growth was more rapid when using the modified lysis/centrifugation technique than when using the conventional method. Statistical analysis revealed a significant difference (pcentrifugation technique showed to be more efficacious than the conventional one, and therefore the implementation of this methodology is highly recommended for the isolation of fungi from blood.

Low-flow operation and testing of pumps in nuclear plants

International Nuclear Information System (INIS)

Greenstreet, W.L.

1989-01-01

Low-flow operation of centrifugal pumps introduces hydraulic instability and other factors that can cause damage to these machines. The resulting degradation has been studied and recorded for pumps in electric power plants. The objectives of this paper are to (1) describe the damage-producing phenomena, including their sources and consequences; (2) relate these observations to expectations for damage caused by low-flow operation of pumps in nuclear power plants; and (3) assess the utility of low-flow testing. Hydraulic behavior during low-flow operation is reviewed for a typical centrifugal pump stage, and the damage-producing mechanisms are described. Pump monitoring practices, in conjunction with pump performance characteristics, are considered; experience data are reviewed; and the effectiveness of low-flow surveillance monitoring is examined. Degradation caused by low-flow operation is shown to be an important factor, and low-flow surveillance testing is shown to be inadequate. 18 refs., 5 figs., 4 tabs

A Centrifugal Microfluidic Platform That Separates Whole Blood Samples into Multiple Removable Fractions Due to Several Discrete but Continuous Density Gradient Sections

Science.gov (United States)

Moen, Scott T.; Hatcher, Christopher L.; Singh, Anup K.

2016-01-01

We present a miniaturized centrifugal platform that uses density centrifugation for separation and analysis of biological components in small volume samples (~5 μL). We demonstrate the ability to enrich leukocytes for on-disk visualization via microscopy, as well as recovery of viable cells from each of the gradient partitions. In addition, we simplified the traditional Modified Wright-Giemsa staining by decreasing the time, volume, and expertise involved in the procedure. From a whole blood sample, we were able to extract 95.15% of leukocytes while excluding 99.8% of red blood cells. This platform has great potential in both medical diagnostics and research applications as it offers a simpler, automated, and inexpensive method for biological sample separation, analysis, and downstream culturing. PMID:27054764

Sealing properties of mechanical seals for an axial flow blood pump.

Science.gov (United States)

Tomioka, J; Mori, T; Yamazaki, K; Koyanagi, H

1999-08-01

A miniature intraventricular axial flow blood pump for left ventricular support is under development. One of the key technologies required for such pumps is sealing of the motor shaft. In this study, to prevent blood backflow into the motor side, mechanical seals were developed and their sealing properties investigated. In the experimental apparatus, the mechanical seal separated the bovine blood on the chamber side from the cooling water on the motor side. A leakage of the blood was measured by inductively coupled plasma (ICP) light emission analysis. The rate of hemolysis was measured by the cyanmethemoglobin method. Frictional torque acting on the shaft was measured by a torque transducer. In the experiments, the rotational speed of the shaft was changed from 1,000 to 10,000 rpm, and the contact force of the seal faces was changed from 1.96 to 4.31 N. To estimate lubrication regimes, the Stribeck curve, a diagram of the coefficient of friction against the bearing characteristic G number, was drawn. The results of the experiments showed that both the leakage of blood and the rate of hemolysis were very small. The friction loss was also very small. The mechanical seal was operated in various lubrication regimes, from a fluid lubrication regime to a mixed lubrication regime.

Numerical Analysis of Blood Damage Potential of the HeartMate II and HeartWare HVAD Rotary Blood Pumps.

Science.gov (United States)

Thamsen, Bente; Blümel, Bastian; Schaller, Jens; Paschereit, Christian O; Affeld, Klaus; Goubergrits, Leonid; Kertzscher, Ulrich

2015-08-01

Implantable left ventricular assist devices (LVADs) became the therapy of choice in treating end-stage heart failure. Although survival improved substantially and is similar in currently clinically implanted LVADs HeartMate II (HM II) and HeartWare HVAD, complications related to blood trauma are frequently observed. The aim of this study was to compare these two pumps regarding their potential blood trauma employing computational fluid dynamics. High-resolution structured grids were generated for the pumps. Newtonian flow was calculated, solving Reynolds-averaged Navier-Stokes equations with a sliding mesh approach and a k-ω shear stress transport turbulence model for the operating point of 4.5 L/min and 80 mm Hg. The pumps were compared in terms of volumes subjected to certain viscous shear stress thresholds, below which no trauma was assumed (von Willebrand factor cleavage: 9 Pa, platelet activation: 50 Pa, and hemolysis: 150 Pa), and associated residence times. Additionally, a hemolysis index was calculated based on a Eulerian transport approach. Twenty-two percent of larger volumes above 9 Pa were observed in the HVAD; above 50 Pa and 150 Pa the differences between the two pumps were marginal. Residence times were higher in the HVAD for all thresholds. The hemolysis index was almost equal for the HM II and HVAD. Besides the gap regions in both pumps, the inlet regions of the rotor and diffuser blades have a high hemolysis production in the HM II, whereas in the HVAD, the volute tongue is an additional site for hemolysis production. Thus, in this study, the comparison of the HM II and the HVAD using numerical methods indicated an overall similar tendency to blood trauma in both pumps. However, influences of turbulent shear stresses were not considered and effects of the pivot bearing in the HM II were not taken into account. Further in vitro investigations are required. Copyright © 2015 International Center for Artificial Organs and Transplantation and

Gas exchange efficiency of an oxygenator with integrated pulsatile displacement blood pump for neonatal patients.

Science.gov (United States)

Schlanstein, Peter C; Borchardt, Ralf; Mager, Ilona; Schmitz-Rode, Thomas; Steinseifer, Ulrich; Arens, Jutta

2014-01-01

Oxygenators have been used in neonatal extracorporeal membrane oxygenation (ECMO) since the 1970s. The need to develop a more effective oxygenator for this patient cohort exists due to their size and blood volume limitations. This study sought to validate the next design iteration of a novel oxygenator for neonatal ECMO with an integrated pulsatile displacement pump, thereby superseding an additional blood pump. Pulsating blood flow within the oxygenator is generated by synchronized active air flow expansion and contraction of integrated silicone pump tubes and hose pinching valves located at the oxygenator inlet and outlet. The current redesign improved upon previous prototypes by optimizing silicone pump tube distribution within the oxygenator fiber bundle; introduction of an oval shaped inner fiber bundle core, and housing; and a higher fiber packing density, all of which in combination reduced the priming volume by about 50% (50 to 27 mL and 41 to 20 mL, respectively). Gas exchange efficiency was tested for two new oxygenators manufactured with different fiber materials: one with coating and one with smaller pore size, both capable of long-term use (OXYPLUS® and CELGARD®). Results demonstrated that the oxygen transfer for both oxygenators was 5.3-24.7 mlO2/min for blood flow ranges of 100-500 mlblood/min. Carbon dioxide transfer for both oxygenators was 3.7-26.3 mlCO2/min for the same blood flow range. These preliminary results validated the oxygenator redesign by demonstrating an increase in packing density and thus in gas transfer, an increase in pumping capacity and a reduction in priming volume.

Blood-mimicking delivery in polygonal structure of inner quadrupletip microneedle with valveless micro-pump

Science.gov (United States)

Ibrahim, M. D.; Yunos, Y. S.; Rigit, A. R. H.; Mohtadzar, N. A. A.; Watanabe, N.; Sunami, Y.; Rahman, M. R. A.; Wong, L. K.; Mohtar, M. Z.

2017-04-01

This paper presents a titanium quadrupletip micro-needle integrated with a micro-pump with different inner designs, length and diameter of the micro-channels to measure and maximize the velocity flow in the micro-needle as blood delivered into human body. Titanium is used as the material of the micro-needle which are also the common material in manufacturing of micro-needle. The advancement of micro-needle technologies is improved in penetrating human outermost skin, stratum corneum and further to human blood vessels. The micro-needles with channel inner design of circular, square, hexagon, and dodecagon with quadruple tip designs are drawn with inner diameter parameter of 150μm and 100μm with two different channel length which are 10mm and 25mm. The characteristics of blood delivery in geometrically changed inner designs affect the output velocity in microneedle when the micropump is operating. The results showed that, when it is pumped at 0.04m/s, the blood velocity improved by 5.6% than when the pump is increased by 30% of its capacity. This is due to the backflow generated in the micropump.

Description of a double centrifugation tube method for concentrating canine platelets.

Science.gov (United States)

Perazzi, Anna; Busetto, Roberto; Martinello, Tiziana; Drigo, Michele; Pasotto, Daniela; Cian, Francesco; Patruno, Marco; Iacopetti, Ilaria

2013-07-22

To evaluate the efficiency of platelet-rich plasma preparations by means of a double centrifugation tube method to obtain platelet-rich canine plasma at a concentration at least 4 times higher than the baseline value and a concentration of white blood cells not exceeding twice the reference range. A complete blood count was carried out for each sample and each concentrate. Whole blood samples were collected from 12 clinically healthy dogs (consenting blood donors). Blood was processed by a double centrifugation tube method to obtain platelet concentrates, which were then analyzed by a flow cytometry haematology system for haemogram. Platelet concentration and white blood cell count were determined in all samples. Platelet concentration at least 4 times higher than the baseline value and a white blood cell count not exceeding twice the reference range were obtained respectively in 10 cases out of 12 (83.3%) and 11 cases out of 12 (91.6%). This double centrifugation tube method is a relatively simple and inexpensive method for obtaining platelet-rich canine plasma, potentially available for therapeutic use to improve the healing process.

Alignment and operability analysis of a vertical sodium pump

International Nuclear Information System (INIS)

Gupta, V.K.; Fair, C.E.

1981-01-01

With the objective of identifying important alignment features of pumps such as FFTF, HALLAM, EBR II, PNC, PHENIX, and CRBR, alignment of the vertical sodium pump for the Clinch River Breeder Reactor Plant (CRBRP) is investigated. The CRBRP pump includes a flexibly coupled pump shaft and motor shaft, two oil-film tilting-pad hydrodynamic radial bearings in the motor plus a vertical thrust bearing, and two sodium hydrostatic bearings straddling the double-suction centrifugal impeller in the pump

On trans-parenchymal transport after blood brain barrier opening: pump-diffuse-pump hypothesis

Science.gov (United States)

Postnov, D. E.; Postnikov, E. B.; Karavaev, A. S.; Glushkovskaya-Semyachkina, O. V.

2018-04-01

Transparenchymal transport attracted the attention of many research groups after the discovery of glymphatic mechanism for the brain drainage in 2012. While the main facts of rapid transport of substances across the parenchyma are well established experimentally, specific mechanisms that drive this drainage are just hypothezised but not proved yed. Moreover, the number of modeling studies show that the pulse wave powered mechanism is unlikely able to perform pumping as suggested. Thus, the problem is still open. In addition, new data obtained under the conditions of intensionally opened blood brain barrier shows the presence of equally fast transport in opposite durection. In our study we investigate the possible physical mechanisms for rapid transport of substances after the opening of blood-brain barrier under the conditions of zero net flow.

Estudio y propuestas de solución para fallos recurrentes en bombas centrífugas horizontales // Study and proposal of solutions to recurrent failures in horizontal centrifugal pumps.

Directory of Open Access Journals (Sweden)

Jesús Cabrera - Gómez

2010-05-01

Full Text Available ResumenLa necesidad de ejecutar la investigación está dada por los fallos recurrentes que están presentandolas bombas centrífugas horizontales que interrumpen el proceso de la planta de alquilación y alimpacto económico asociado a los fallos que han tenido un elevado costo por acciones demantenimiento preventivas y reactivas, en adición a los costos asociados por pérdida deoportunidad. Se llevó a cabo un estudio para establecer las causas que originan los reiterados fallosocurridos en el sistema de bombeo. Como resultado del trabajo realizado, se identificaronoportunidades de mejora de la disponibilidad de los activos estudiados por la vía del incremento de lavida útil del los sellos mecánicos y finalmente se propuso un programa de acciones correctivas alque debe darse seguimiento y que debe tributar a la solución permanente de los problemasidentificados.Palabras claves: mantenimiento de equipos rotatorios, fallos recurrentes, confiabilidad operacional,_________________________________________________________AbstractThe necessity of making the research outlined in this paper is given by recurrent failures in a set ofhorizontal centrifugal pumps. These failures interrupt the operating process in an alkylation plant andgenerate a great negative economic impact because of incrementing maintenance costs andopportunity losses. A study was carried out in order to establish the main causes of repeated failuresin the pumping system. As a result, several improvement opportunities of availability of pumps wereidentified by increasing the useful life of their mechanical seals. Finally, a corrective action programwas proposed in order to provide permanent solutions to identified problems.Key words: maintenance of rotating equipment, recurrent failures, operational reliability, root causeanalysis, horizontal centrifugal pumps.análisis de causa raíz, bombas centrífugas horizontales

Multimodal flow visualization and optimization of pneumatic blood pump for sorbent hemodialysis system.

Science.gov (United States)

Shu, Fangjun; Parks, Robert; Maholtz, John; Ash, Steven; Antaki, James F

2009-04-01

Renal Solutions Allient Sorbent Hemodialysis System utilizes a two-chambered pneumatic pump (Pulsar Blood Pump, Renal Solutions, Inc., Warrendale, PA, USA) to avoid limitations associated with peristaltic pumping systems. Single-needle access is enabled by counter-pulsing the two pump chambers, thereby obviating compliance chambers or blood reservoirs. Each chamber propels 20 cc per pulse of 3 s (dual access) or 6 s (single access) duration, corresponding to a peak Reynolds number of approximately 8000 (based on inlet velocity and chamber diameter). A multimodal series of flow visualization studies (tracer particle, dye washout, and dye erosion) was conducted on a sequence of pump designs with varying port locations and diaphragms to improve the geometry with respect to risk of thrombogenesis. Experiments were conducted in a simplified flow loop using occluders to simulate flow resistance induced by tubing and dialyzer. Tracer visualization revealed flow patterns and qualitatively indicated turbulence intensity. Dye washout identified dwell volume and areas of flow stagnation for each design. Dye erosion results indicated the effectiveness and homogeneity of surface washing. Compared to a centered inlet which resulted in a fluid jet that produced two counter-rotating vortices, a tangential inlet introduced a single vortex, and kept the flow laminar. It also provided better surface washing on the pump inner surface. However, a tangential outlet did not present as much benefit as expected. On the contrary, it created a sharp defection to the flow when transiting from filling to ejection.

Deairing Techniques for Double-Ended Centrifugal Total Artificial Heart Implantation.

Science.gov (United States)

Karimov, Jamshid H; Horvath, David J; Byram, Nicole; Sunagawa, Gengo; Grady, Patrick; Sinkewich, Martin; Moazami, Nader; Sale, Shiva; Golding, Leonard A R; Fukamachi, Kiyotaka

2017-06-01

The unique device architecture of the Cleveland Clinic continuous-flow total artificial heart (CFTAH) requires dedicated and specific air-removal techniques during device implantation in vivo. These procedures comprise special surgical techniques and intraoperative manipulations, as well as engineering design changes and optimizations to the device itself. The current study evaluated the optimal air-removal techniques during the Cleveland Clinic double-ended centrifugal CFTAH in vivo implants (n = 17). Techniques and pump design iterations consisted of developing a priming method for the device and the use of built-in deairing ports in the early cases (n = 5). In the remaining cases (n = 12), deairing ports were not used. Dedicated air-removal ports were not considered an essential design requirement, and such ports may represent an additional risk for pump thrombosis. Careful passive deairing was found to be an effective measure with a centrifugal pump of this design. In this report, the techniques and design changes that were made during this CFTAH development program to enable effective residual air removal and prevention of air embolism during in vivo device implantation are explained. © 2016 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

Estimation of pump operational state with model-based methods

International Nuclear Information System (INIS)

Ahonen, Tero; Tamminen, Jussi; Ahola, Jero; Viholainen, Juha; Aranto, Niina; Kestilae, Juha

2010-01-01

Pumps are widely used in industry, and they account for 20% of the industrial electricity consumption. Since the speed variation is often the most energy-efficient method to control the head and flow rate of a centrifugal pump, frequency converters are used with induction motor-driven pumps. Although a frequency converter can estimate the operational state of an induction motor without external measurements, the state of a centrifugal pump or other load machine is not typically considered. The pump is, however, usually controlled on the basis of the required flow rate or output pressure. As the pump operational state can be estimated with a general model having adjustable parameters, external flow rate or pressure measurements are not necessary to determine the pump flow rate or output pressure. Hence, external measurements could be replaced with an adjustable model for the pump that uses estimates of the motor operational state. Besides control purposes, modelling the pump operation can provide useful information for energy auditing and optimization purposes. In this paper, two model-based methods for pump operation estimation are presented. Factors affecting the accuracy of the estimation methods are analyzed. The applicability of the methods is verified by laboratory measurements and tests in two pilot installations. Test results indicate that the estimation methods can be applied to the analysis and control of pump operation. The accuracy of the methods is sufficient for auditing purposes, and the methods can inform the user if the pump is driven inefficiently.

Investigation on Thrust and Moment Coefficients of a Centrifugal Turbomachine

Directory of Open Access Journals (Sweden)

Bo Hu

2018-04-01

Full Text Available In radial pumps and turbines, the centrifugal through-flow in both the front and the back chambers is quite common. It strongly impacts the core swirl ratio, pressure distribution, axial thrust and frictional torque. In order to investigate these relationships experimentally, a test rig was designed at the University of Duisburg-Essen and described in this paper. Based on both the experimental and numerical results, correlations are determined to predict the impacts of the centrifugal through-flow on the core swirl ratio, the thrust coefficient and the moment coefficient. Two correlations respectively are determined to associate the core swirl ratio with the local through-flow coefficient for both Batchelor type flow and Stewartson type flow. The correlations describing the thrust coefficient and the moment coefficient in a rotor-stator cavity with centripetal through-flow (Hu et al., 2017 are modified for the case of centrifugal through-flow. The Daily and Nece diagram distinguishing between different flow regimes in rotor-stator cavities is extended with a through-flow coordinate into 3D. The achieved results provide a comprehensive data base which is intended to support the calculation of axial thrust and moment coefficients during the design process of radial pumps and turbines in a more accurate manner.

Nuclear power plant safety related pump issues

Energy Technology Data Exchange (ETDEWEB)

Colaccino, J.

1996-12-01

This paper summarizes of a number of pump issues raised since the Third NRC/ASME Symposium on Valve and Pump Testing in 1994. General issues discussed include revision of NRC Inspection Procedure 73756, issuance of NRC Information Notice 95-08 on ultrasonic flow meter uncertainties, relief requests for tests that are determined by the licensee to be impractical, and items in the ASME OM-1995 Code, Subsection ISTB, for pumps. The paper also discusses current pump vibration issues encountered in relief requests and plant inspections - which include smooth running pumps, absolute vibration limits, and vertical centrifugal pump vibration measurement requirements. Two pump scope issues involving boiling water reactor waterlog and reactor core isolation cooling pumps are also discussed. Where appropriate, NRC guidance is discussed.

Nuclear power plant safety related pump issues

International Nuclear Information System (INIS)

Colaccino, J.

1996-01-01

This paper summarizes of a number of pump issues raised since the Third NRC/ASME Symposium on Valve and Pump Testing in 1994. General issues discussed include revision of NRC Inspection Procedure 73756, issuance of NRC Information Notice 95-08 on ultrasonic flow meter uncertainties, relief requests for tests that are determined by the licensee to be impractical, and items in the ASME OM-1995 Code, Subsection ISTB, for pumps. The paper also discusses current pump vibration issues encountered in relief requests and plant inspections - which include smooth running pumps, absolute vibration limits, and vertical centrifugal pump vibration measurement requirements. Two pump scope issues involving boiling water reactor waterlog and reactor core isolation cooling pumps are also discussed. Where appropriate, NRC guidance is discussed

Platelet concentration of plateletrich plasma from dogs, obtained through three centrifugation speeds

Directory of Open Access Journals (Sweden)

Vanessa Couto de Magalhães Ferraz

2007-12-01

Full Text Available The platelets release at least 4 growth factors (Platelet Derived Growth Factor. ²1 and ²2 Transforming Growth Factors and Insulin-like Growth Factor which are responsible for the migration and activation of cells that will start the reparation of soft tissues and bones. The Platelet Rich Plasma is an autogenous source for Growth Factors, obtained by platelet concentration by centrifuging total blood. This study aimed the comparison of platelet concentrations in plasma centrifuged in three different centrifugation speeds (1300, 1600 e 3200rpm, for the production of platelet rich plasma. Blood was drowned from 15 dogs, 40ml of each, and these were divided into four groups and centrifuged at 800rpm. Then the first group was centrifuged at 1300rpm, the second at 1600rpm, the third at 3200rpm and the last was used as control, named plasma. The mean percentage increase in the platelet concentration for each technique was: 1300 - 183%, 1600 - 210% and 3200 - 222%. But in centrifugation at 3200 rpm, platelets presented altered morphology and different sizes in every sample studied, which was understood as severe cell damage. It was concluded that the best technique for the preparation of the platelet rich plasma in dogs consisted of the previous centrifugation of the blood at 800rpm for ten minutes, and then the plasma should be separated. This plasma is then submitted to a second centrifugation of 1600rpm for 10 minutes, and the platelet poor plasma is separated and discharged.

Mathematical model of the reactor coolant pump

International Nuclear Information System (INIS)

Kozuh, M.

1989-01-01

The mathematical model of reactor coolant pump is described in this paper. It is based on correlations for centrifugal reactor coolant pumps. This code is one of the elements needed for the simulation of the whole NPP primary system. In subroutine developed according to this model we tried in every possible detail to incorporate plant specific data for Krsko NPP. (author)

Centrifugal turbocompressor with contactless sealing for H-2 S

International Nuclear Information System (INIS)

Peculea, M.; Balint, I.; Hirean, I.; Dumitrescu, C.; Pitigoi, Gh.; Balanuca, C.

1995-01-01

This paper reports the development of a centrifugal turbocompressor with contactless sealing for H 2 S specially designed for the ROMAG Drobeta heavy water plant. The bench-scale experiments are described and the resulted main characteristics are given. For this equipment an asymmetric automatic anti-pumping protection system has been developed and patented

A centrifuge-less plasma separation method from whole blood anticoagulated with EDTA-2K for the use of clinical laboratory tests.

Science.gov (United States)

Tatsumi, N; Tsuda, I; Fukumori, T; Hino, M; Takubo, T; Kondo, H

2001-12-01

In the modern medical laboratory system, simple and rapid processing of specimens are required. In the current system with the transportation line, its centrifugation part would disturb smooth flow of the testing because it needs much time for the centrifugation. To solve the problems, a serum separation method was tried for the whole blood specimen using poly-L-lysine, concanavalin A and phyto-hemoagglutinin. Ploy-L-lysine with molecular weight 130,000 to 210,000 in a final concentration of 0.1% could accelerate blood sedimentation, although its supernatant contaminated platelets. Concanavalin and phytohemoagulutinin could accelerate the sedimentation and obtained plasma, but the method could yield enough amount of supernatant by 1 hour standing. As the purpose of this study is to develop a centrifugeless method, a sieve method using a steel mesh and a magnet was applied to the mixture of EDTA blood, red-cell adhesives and thrombin. The method was unique to separate plasma, but the yield was not so high and chemistry data were not fitted with serum data in some of tests. Thus, the trial would be a new technology, but it was judged that some further improvement will be needed technically.

Laboratory evaluation of the emulsifying characteristics of pumps. [Bilge and ballast water oily wastes

Energy Technology Data Exchange (ETDEWEB)

Harvey, A.C.; Guzdar, A.R.; Fiswell, D.R.

1973-10-01

The program was devoted to a laboratory investigation of the emulsifying characteristics of different pumps suitable for shipboard pumping of bilge and ballast water oily wastes. The tests were designed to investigate the effect of several parameters, such as oil type, input oil concentration, detergent, pump operating characteristics (pressure and flow rate), and salt versus fresh water, on emulsification. Tests were conducted on the Foster-Miller tests loop. No. 2 fuel oil, lubricating oil and No. 6 fuel oil were the oils tested at concentrations ranging from 1 to 10%. The oils were tested with and without the addition of 10% Gamlen D surfactant. The pumps used were a Parker Diaphragm pump, a Blackmer Sliding Vane pump, an Ingersoll Rand Centrifugal pump and a Deming Centrifugal pump. Pump pressure ranged from 10 to 60 psi and flow rate from 10 to 100 gpm. A total of 270 tests were conducted covering 198 different operating points, 108 concerning pump comparison, 54 concerning oil concentration and surfactant, and 45 concerning salt water.

Pumps in wearable ultrafiltration devices: pumps in wuf devices.

Science.gov (United States)

Armignacco, Paolo; Garzotto, Francesco; Bellini, Corrado; Neri, Mauro; Lorenzin, Anna; Sartori, Marco; Ronco, Claudio

2015-01-01

The wearable artificial kidney (WAK) is a device that is supposed to operate like a real kidney, which permits prolonged, frequent, and continuous dialysis treatments for patients with end-stage renal disease (ESRD). Its functioning is mainly related to its pumping system, as well as to its dialysate-generating and alarm/shutoff ones. A pump is defined as a device that moves fluids by mechanical action. In such a context, blood pumps pull blood from the access side of the dialysis catheter and return the blood at the same rate of flow. The main aim of this paper is to review the current literature on blood pumps, describing the way they have been functioning thus far and how they are being engineered, giving details about the most important parameters that define their quality, thus allowing the production of a radar comparative graph, and listing ideal pumps' features. © 2015 S. Karger AG, Basel.

85,000-GPM, single-stage, single-suction LMFBR intermediate centrifugal pump

International Nuclear Information System (INIS)

Fair, C.E.; Cook, M.E.; Huber, K.A.; Rohde, R.

1983-01-01

The mechanical and hydraulic design features of the 85,000-gpm, single-stage, single-suction pump test article, which is designed to circulate liquid-sodium coolant in the intermediate heat-transport system of a Large-Scale Liquid Metal Fast Breeder Reactor (LS-LMFBR), are described. The design and analytical considerations used to satisfy the pump performance and operability requirements are presented. The validation of pump hydraulic performance using a hydraulic scale-model pump is discussed, as is the featute test for the mechanical-shaft seal system

The Heartmate III: design and in vivo studies of a maglev centrifugal left ventricular assist device.

Science.gov (United States)

Loree, H M; Bourque, K; Gernes, D B; Richardson, J S; Poirier, V L; Barletta, N; Fleischli, A; Foiera, G; Gempp, T M; Schoeb, R; Litwak, K N; Akimoto, T; Kameneva, M; Watach, M J; Litwak, P

2001-05-01

A compact implantable centrifugal left ventricular assist device (LVAD) (HeartMate III) featuring a magnetically levitated impeller is under development. The goal of our ongoing work is to demonstrate feasibility, low hemolysis, and low thrombogenicity of the titanium pump in chronic bovine in vivo studies. The LVAD is based on so-called bearingless motor technology and combines pump rotor, drive, and magnetic bearing functions in a single unit. The impeller is rotated (theta z) and levitated with both active (X, Y) and passive (Z, theta x, theta y) suspension. Six prototype systems have been built featuring an implantable titanium pump (69 mm diameter, 30 mm height) with textured blood contacting surfaces and extracorporeal electronics. The pumps were implanted in 9 calves (< or = 100 kg at implant) that were anticoagulated with Coumadin (2.5 < or = INR < or = 4.0) throughout the studies. Six studies were electively terminated (at 27-61 days), 1 study was terminated after the development of severe pneumonia and lung atelectasis (at 27 days) another study was terminated after cardiac arrest (at 2 days) while a final study is ongoing (at approximately 100 days). Mean pump flows ranged from 2 to 7 L/min, except for brief periods of exercise at 6 to 9 L/min. Plasma free hemoglobin ranged from 4 to 10 mg/dl. All measured biochemical indicators of end organ function remained within normal range. The pumps have met performance requirements in all 9 implants with acceptable hemolysis and no mechanical failures.

Alignment analysis of a vertical sodium pump

International Nuclear Information System (INIS)

Gupta, V.K.; Fair, C.E.

1981-01-01

With the objective of identifying important alignment features of pumps such as FFTF, HALLAM, EBR II, PNC, PHENIX, and CRBR, alignment of the vertical sodium pump for the Clinch River Breeder Reactor Plant (CRBRP) is investigated. The CRBRP pump includes a flexibly coupled pump shaft and motor shaft, two oil-film tilting-pad hydrodynamic radial bearings in the motor plus a vertical thrust bearing, and two sodium hydrostatic bearings straddling the double-suction centrifugal impeller in the pump. The assembled CRBRP prototype pump shows smooth predictable vibration behavior experienced during water test. An ealier swing check of the pump shaft about the motor shaft hub demonstrated that the pump is relatively insensitive to manufacturing and assembly tolerances, a consequence of close dimensional control and unique alignment features. (orig./GL)

Operating states of PFBR-primary sodium pump

International Nuclear Information System (INIS)

Sreedharan, K.V.; Rao, A.S.L.K.; Raju, C.; Kale, R.D.

1994-01-01

The proposed 500 MWe Prototype Fast Breeder Reactor (PFBR), the design of which is in progress at the Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam will be equipped with four centrifugal sodium pumps each in its primary and secondary circuits. This paper discusses the various operating states of the primary pumps viz. (i) normal steady state (ii) transient state operation. The paper also discusses the safe limits on the pump operating speed and a few design basis incidents. (author). 1 ref., 2 figs., 3 tabs

Influence of the centrifuge time of primary plasma tubes on routine coagulation testing.

Science.gov (United States)

Lippi, Giuseppe; Salvagno, Gian Luca; Montagnana, Martina; Manzato, Franco; Guidi, Gian Cesare

2007-07-01

Preparation of blood specimens is a major bottleneck in the laboratory throughput. Reliable strategies for reducing the time required for specimen processing without affecting quality should be acknowledged, especially for laboratories performing stat analyses. The present investigation was planned to establish a minimal suitable centrifuge time for primary samples collected for routine coagulation testing. Five sequential primary vacuum tubes containing 0.109 mol/l buffered trisodium citrate were collected from 10 volunteers and were immediately centrifuged on a conventional centrifuge at 1500 x g, at room temperature for 1, 2, 5, 10 and 15 min, respectively. Hematological and routine coagulation testing, including prothrombin time, activated partial thromboplastin time and fibrinogen, were performed. The centrifugation time was inversely associated with residual blood cell elements in plasma, especially platelets. Statistically significant variations from the reference 15-min centrifuge specimens were observed for fibrinogen in samples centrifuged for 5 min at most and for the activated partial thromboplastin time in samples centrifuged for 2 min at most. Meaningful biases related to the desirable bias were observed for fibrinogen in samples centrifuged for 2 min at most, and for the activated partial thromboplastin time in samples centrifuged for 1 min at most. According to our experimental conditions, a 5-10 min centrifuge time at 1500 x g may be suitable for primary tubes collected for routine coagulation testing.

Pump failure leads to alternative vertical pump condition monitoring technique

International Nuclear Information System (INIS)

DeVilliers, Adriaan; Glandon, Kevin

2011-01-01

Condition monitoring and detecting early signs of potential failure mechanisms present particular problems in vertical pumps. Most often, the majority of the pump assembly is not readily accessible for visual or audible inspection or conventional vibration monitoring techniques using accelerometers and/or proximity sensors. The root cause failure analysis of a 2-stage vertical centrifugal service-water pump at a nuclear power generating facility in the USA is presented, highlighting this long standing challenge in condition monitoring of vertical pumps. This paper will summarize the major findings of the root cause analysis (RCA), highlight the limitations of traditional monitoring techniques, and present an expanded application of motor current monitoring as a means to gain insight into the mechanical performance and condition of a pump. The 'real-world' example of failure, monitoring and correlation of the monitoring technique to a detailed pump disassembly inspection is also presented. This paper will explain some of the reasons behind well known design principles requiring natural frequency separation from known forcing frequencies, as well as explore an unexpected submerged brittle fracture failure mechanism, and how such issues may be avoided. (author)

The effect of centrifugation speed and time on pre-analytical platelet activation.

Science.gov (United States)

Söderström, Anna C; Nybo, Mads; Nielsen, Christian; Vinholt, Pernille J

2016-12-01

The results of laboratory analyses are affected by pre-analytical variables, and in particular can platelets be activated by shear handling stress and secrete granular substances. We therefore evaluated the effect of centrifugation speed and time on pre-analytical platelet activation. Citrate- and EDTA-anticoagulated blood from healthy volunteers were centrifuged at 80-10,000 g for 5-15 min to prepare plasma and platelet-rich plasma. Pre-analytical platelet activation was assessed by flow cytometric measurement of platelet P-selectin (CD62p) expression. Blood cell counts, mean platelet volume (MPV), immature platelet fraction (IPF), and platelet distribution width (PDW) were measured. Platelet aggregation in platelet-rich plasma induced by arachidonic acid (AA), ADP or thrombin receptor activator peptide-6 (TRAP) was tested by 96-well aggregometry. The median percentage of platelets expressing P-selectin in citrate- and EDTA-plasma centrifuged at 2000 g for 10 min were 43% [interquartile range (IQR), 38%-53%] and 56% (IQR, 31%-78%), respectively (p=0.82). Platelet-rich plasma prepared at 100-250 g for 10 min had significantly lower platelet P-selectin expression (11%-15%), pcentrifuged. In platelet-rich plasma, increasing centrifugation speed significantly increased platelet yield but decreased contamination from other blood cells, platelet composition was altered as platelet parameters (MPV, IPF, and PDW) was lowered. Platelet aggregation was not affected by the centrifugation speed platelet-rich plasma was prepared. Proportional to centrifugation speed, platelets in plasma and platelet-rich plasma were activated with centrifugation speed, cell content and composition changed while platelet aggregation was unaltered.

Evaluation of the impact of density gradient centrifugation on fetal cell loss during enrichment from maternal peripheral blood.

Science.gov (United States)

Emad, Ahmed; Drouin, Régen

2014-09-01

Physical separation by density gradient centrifugation (DGC) is usually used as an initial step of multistep enrichment protocols for purification of fetal cells (FCs) from maternal blood. Many protocols were designed but no single approach was efficient enough to provide noninvasive prenatal diagnosis. Procedures and methods were difficult to compare because of the nonuniformity of protocols among different groups. Recovery of FCs is jeopardized by their loss during the process of enrichment. Any loss of FCs must be minimized because of the multiplicative effect of each step of the enrichment process. The main objective of this study was to evaluate FC loss caused by DGC. Fetal cells were quantified in peripheral blood samples obtained from both euploid and aneuploid pregnancies before and after enrichment by buoyant DGC using Histopaque 1.119 g/mL. Density gradient centrifugation results in major loss of 60% to 80% of rare FCs, which may further complicate subsequent enrichment procedures. Eliminating aggressive manipulations can significantly minimize FC loss. Data obtained raise questions about the appropriateness of the DGC step for the enrichment of rare FCs and argues for the use of the alternative nonaggressive version of the procedure presented here or prioritizing other methods of enrichments. © 2014 John Wiley & Sons, Ltd.

Pump station for radioactive waste water

Science.gov (United States)

Whitton, John P.; Klos, Dean M.; Carrara, Danny T.; Minno, John J.

2003-11-18

A pump station for transferring radioactive particle containing waste water, includes: (a.) an enclosed sump having a vertically elongated right frusto conical wall surface and a bottom surface and (b.) a submersible volute centrifugal pump having a horizontally rotating impeller and a volute exterior surface. The sump interior surface, the bottom surface and the volute exterior surface are made of stainless steel having a 30 Ra or finer surface finish. A 15 Ra finish has been found to be most cost effective. The pump station is used for transferring waste water, without accumulation of radioactive fines.

Closed continuous-flow centrifuge rotor

Science.gov (United States)

Breillatt, Jr., Julian P.; Remenyik, Carl J.; Sartory, Walter K.; Thacker, Louis H.; Penland, William Z.

1976-01-01

A blood separation centrifuge rotor having a generally parabolic core disposed concentrically and spaced apart within a housing having a similarly shaped cavity. Blood is introduced through a central inlet and into a central passageway enlarged downwardly to decrease the velocity of the entrant blood. Septa are disposed inside the central passageway to induce rotation of the entrant blood. A separation chamber is defined between the core and the housing wherein the whole blood is separated into red cell, white cell, and plasma zones. The zones are separated by annular splitter blades disposed within the separation chamber. The separated components are continuously removed through conduits communicating through a face seal to the outside of the rotor.

Hematocrit analysis through the use of an inexpensive centrifugal polyester-toner device with finger-to-chip blood loading capability

International Nuclear Information System (INIS)

Thompson, Brandon L.; Gilbert, Rachel J.; Mejia, Maximo; Shukla, Nishant; Haverstick, Doris M.; Garner, Gavin T.; Landers, James P.

2016-01-01

Hematocrit (HCT) measurements are important clinical diagnostic variables that help physicians diagnose and treat various medical conditions, ailments, and diseases. In this work, we present the HCT Disc, a centrifugal microdevice fabricated by a Print, Cut and Laminate (PCL) method to generate a 12-sample HCT device from materials costing <0.5 USD (polyester and toner or PeT). Following introduction from a drop of blood (finger stick), whole blood metering and cell sedimentation are controlled by centrifugal force, only requiring a CD player motor as external hardware and, ultimately, a cell phone for detection. The sedimented volume from patient blood in the HCT Disc was analyzed using a conventional scanner/custom algorithm for analysis of the image to determine a hematocrit value, and these were compared to values generated in a clinical laboratory, which correlated well. To enhance portability and assure simplicity of the HCT measurement, values from image analysis by a cell phone using a custom application was compared to the scanner. Fifteen samples were analyzed with cell phone image analysis system and were found to be within 4% of the HCT values determined in the clinical lab. We demonstrate the feasibility of the PeT device for HCT measurement, and highlight its uniquely low cost (<0.5 USD), speed (sample-to-answer <8 min), multiplexability (12 samples), low volume whole blood requirement (<3 μL), rotation speeds (<4000 rpm) needed for effective measurement as well as the direct finger-to-chip sample loading capability. - Highlights: • A 12-sample hematocrit device was developed from polyester-toner materials. • The device can analyze a patient's hematocrit within 8 min from 3 μL of blood. • Cell phone image analysis is used to correctly determine clinical hematocrits.

Hematocrit analysis through the use of an inexpensive centrifugal polyester-toner device with finger-to-chip blood loading capability

Energy Technology Data Exchange (ETDEWEB)

Thompson, Brandon L.; Gilbert, Rachel J. [Department of Chemistry, McCormick Road, University of Virginia, Charlottesville, VA 22904 (United States); Mejia, Maximo [Department of Mechanical Engineering, Engineer' s Way, University of Virginia, Charlottesville, VA 22904 (United States); Shukla, Nishant [Department of Computer Science, Engineer' s Way, University of Virginia, Charlottesville, VA 22904 (United States); Haverstick, Doris M. [Department of Pathology, University of Virginia Health Science Center, Charlottesville, VA 22908 (United States); Garner, Gavin T. [Department of Mechanical Engineering, Engineer' s Way, University of Virginia, Charlottesville, VA 22904 (United States); Landers, James P., E-mail: landers@virginia.edu [Department of Chemistry, McCormick Road, University of Virginia, Charlottesville, VA 22904 (United States); Department of Mechanical Engineering, Engineer' s Way, University of Virginia, Charlottesville, VA 22904 (United States); Department of Pathology, University of Virginia Health Science Center, Charlottesville, VA 22908 (United States)

2016-06-14

Hematocrit (HCT) measurements are important clinical diagnostic variables that help physicians diagnose and treat various medical conditions, ailments, and diseases. In this work, we present the HCT Disc, a centrifugal microdevice fabricated by a Print, Cut and Laminate (PCL) method to generate a 12-sample HCT device from materials costing <0.5 USD (polyester and toner or PeT). Following introduction from a drop of blood (finger stick), whole blood metering and cell sedimentation are controlled by centrifugal force, only requiring a CD player motor as external hardware and, ultimately, a cell phone for detection. The sedimented volume from patient blood in the HCT Disc was analyzed using a conventional scanner/custom algorithm for analysis of the image to determine a hematocrit value, and these were compared to values generated in a clinical laboratory, which correlated well. To enhance portability and assure simplicity of the HCT measurement, values from image analysis by a cell phone using a custom application was compared to the scanner. Fifteen samples were analyzed with cell phone image analysis system and were found to be within 4% of the HCT values determined in the clinical lab. We demonstrate the feasibility of the PeT device for HCT measurement, and highlight its uniquely low cost (<0.5 USD), speed (sample-to-answer <8 min), multiplexability (12 samples), low volume whole blood requirement (<3 μL), rotation speeds (<4000 rpm) needed for effective measurement as well as the direct finger-to-chip sample loading capability. - Highlights: • A 12-sample hematocrit device was developed from polyester-toner materials. • The device can analyze a patient's hematocrit within 8 min from 3 μL of blood. • Cell phone image analysis is used to correctly determine clinical hematocrits.

Comportamiento no lineal y caótico en una bomba centrífuga operando en estado de cavitación//Nonlinear and chaotic behavior in a centrifugal pump operating in state of cavitation

Directory of Open Access Journals (Sweden)

Juan E. Álvarez Naranjo

2015-05-01

Full Text Available Mejorar la precisión en el diagnóstico y pronóstico del mantenimiento industrial ha sido una tarea de constante investigación debido a la necesidad de preservar el continuo funcionamiento de las máquinas de producción. En el presentetrabajo se estudió la bomba centrífuga en estado de cavitación. Se construyó un banco de pruebas y mediante obstrucción del fluido hacia el rodete del equipo por medio de la válvula de succión, se registraron las señales temporales mediante un acelerómetro. Posteriormente, se empleó un estudio no lineal y caótico para representar la geometría en el espacio de fases y su validación se realizó con el registro de datos de la bomba centrífuga operando sin cavitación y con máxima eficiencia. Los resultados mostraron que la dinámica del sistema actúa de forma no lineal y caótica, representado el fenómeno de cavitación con una geometría característica.Palabras claves: bomba centrífuga, cavitación, caos, dinámica no lineal, espacio de fases, serie temporal.______________________________________________________________________________AbstractImproving accuracy in the diagnosis and prognosis of industrial maintenance has been a constant task of research to preserve the continuous operation of machines. Today is necessary to improve this technique for avoiding reductionism that the traditional linear techniques employ. In this paper it is studied the centrifugal pump cavitation state. To simulate the phenomenon, a test bed is constructed and the fluid is blocked toward the impeller of pump by the suction valve, the time signals were recorded using an accelerometer. Subsequently, a chaotic nonlinear study was used to represent the geometry in the phase space and validation was performed with the data recording operation of the centrifugal pump without cavitation and with maximum efficiency. The results showed that the system dynamics is non-linear and chaotic, and the cavitation is represented

Modelling of Station of Pumping by Variable Speed

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Benretem A.

2016-05-01

Full Text Available An increased energetic efficiency will make it possible to decrease the factory operating costs and hence to increase productivity. The centrifugal pumps are largely used because of their relatively simple operation and of their purchase price. One analyses thorough requirements imposed by the pumping plants is decisive. It is important to keep in mind the fact that the pumps consume approximately 20% of energy in the world. They constitute the possibility for the most significant efficiency improvement. They can reach their maximum effectiveness only with one pressure and a given flow. The approach suggested makes it possible to adapt with accuracy and effectiveness of system output of the industrial process requirements. The variable speed drive is one of best and effective techniques studied to reach this objective. The appearance of this technique comes only after the evolution obtained in the field of power electronics systems precisely static inverters as well as the efforts made by the researchers in the field of electric drive systems. This work suggested is the result of an in-depth study on the effectiveness of this new technique applied for the centrifugal pumps.

Theoretical prediction and validation of cell recovery rates in preparing platelet-rich plasma through a centrifugation.

Science.gov (United States)

Piao, Linfeng; Park, Hyungmin; Jo, Chris Hyunchul

2017-01-01

In the present study, we propose a theoretical framework to predict the recovery rates of platelets and white blood cells in the process of centrifugal separation of whole blood contained in a tube for the preparation of platelet-rich plasma. Compared to previous efforts to optimize or standardize the protocols of centrifugation, we try to further the physical background (i.e., based on the multiphase flow phenomena) of analysis to develop a universal approach that can be applied to widely different conditions. That is, one-dimensional quasi-linear partial differential equation to describe the centrifugal sedimentation of dispersed phase (red and white blood cells) in continuous phase (plasma) is derived based on the kinematic-wave theory. With the information of whole blood volume and tube geometry considered, it is possible to determine the positions of interfaces between supernatant/suspension and suspension/sediment, i.e., the particle concentration gradient in a tube, for a wide range of centrifugation parameters (time and acceleration). While establishing a theory to predict the recovery rates of the platelet and white blood cell from the pre-determined interface positions, we also propose a new correlation model between the recovery rates of plasma and platelets, which is found to be a function of the whole blood volume, centrifugal time and acceleration, and tube geometry. The present predictions for optimal condition show good agreements with available human clinical data, obtained from different conditions, indicating the universal applicability of our method. Furthermore, the dependence of recovery rates on centrifugal conditions reveals that there exist a different critical acceleration and time for the maximum recovery rate of platelets and white blood cells, respectively. The other parameters such as hematocrit, whole blood volume and tube geometry are also found to strongly affect the maximum recovery rates of blood cells, and finally, as a strategy

Reactor coolant pumps for nuclear reactors

International Nuclear Information System (INIS)

Harand, E.; Richter, G.; Tschoepel, G.

1975-01-01

A brake for the pump rotor of a main coolant pump or a shutoff member on the pump are provided in order to prevent excess speeds of the pump rotor. Such excess speeds may occur in PWR type reactors with water at a pressure below, e.g., 150 bars if there is leakage from a coolant line associated with the main coolant pump. As a brake, a centrifugal brake depending upon the pump speed or a brake ring arranged on the pump housing and acting on the pump rotor, which ring would be activated by pressure differentials in the pump, may be used. If the pressure differences between suction and pressure sockets are very small, a controlled hydraulic increase of the pressure force on the brake may also be provided. Furthermore, a turbine brake may be provided. A slide which is automatically movable in closing position along the pump rotor axis is used as a shutoff element. It is of cylindrical configuration and is arranged concentrically with the rotor axis. (DG) [de

Observations on centrifugation: application to centrifuge development.

Science.gov (United States)

Roberts, T; Smith, M; Roberts, B

1999-11-01

This report outlines the background to the development of an automated, serial, discrete centrifuge, reporting on the criteria considered essential in such an instrument. We established the criteria by examining the detailed logistics of centrifuge operation in a hospital laboratory. The mean sample load per run, using six centrifuges, was 13.6 samples, and the user-selectable cycle time ranged from 00:01:10 to 00:12:33 (hours:minutes:seconds) with a fixed g value of 1050. During the laboratory working window, (0900-1700), only 50% of the centrifuge capacity was utilized and more than one-third of the sample workload was delayed for >5 min because the centrifuges were not emptied promptly. In addition, 35% of the sample workload was centrifuged for less than the time prescribed in the operational specifications. Based on these findings, we designed a new continuous, serial centrifuge to overcome some of the deficiencies noted in the logistics study. The centrifuge operates continuously, nominally treating 150 samples/h, with a cycle time of 5 min at 1,000 g. The cycle time and g value are variable between limits, and their selection governs the throughput rate. Each sample is centrifuged separately in individual rotors mounted in a sturdy carousel with a periphery that traverses a load/unload station. There is no sample delay because of operator absence, and the capacity is fully utilized. The centrifuge can operate in a stand-alone capacity or has the capability of being integrated into a sample preparation system or as a direct front end for high-throughput analyzers.

Isolating peripheral lymphocytes by density gradient centrifugation and magnetic cell sorting.

Science.gov (United States)

Brosseron, Frederic; Marcus, Katrin; May, Caroline

2015-01-01

Combining density gradient centrifugation with magnetic cell sorting provides a powerful tool to isolate blood cells with high reproducibility, yield, and purity. It also allows for subsequent separation of multiple cell types, resulting in the possibility to analyze different purified fractions from one donor's sample. The centrifugation step divides whole blood into peripheral blood mononuclear cells (PBMC), erythrocytes, and platelet-rich plasma. In the following, lymphocyte subtypes can be consecutively isolated from the PBMC fraction. This chapter describes enrichment of erythrocytes, CD14-positive monocytes and CD3-positive T lymphocytes. Alternatively, other cell types can be targeted by using magnetic beads specific for the desired subpopulation.

Clinical evaluation of the Spiral Pump® after improvements to the original project in patients submitted to cardiac surgeries with cardiopulmonary bypass

Directory of Open Access Journals (Sweden)

Jarbas Jakson Dinkhuysen

2014-09-01

Full Text Available Objective: The objective of this paper is to present the results from Spiral Pump clinical trial after design modifications performed at its previous project. This pump applies axial end centrifugal hydraulic effects for blood pumping during cardiopulmonary bypass for patients under cardiac surgery. Methods: This study was performed in 52 patients (51% males, between 20 to 80 (67±14.4 years old weighing 53 to 102 (71.7±12.6 kg, mostly under myocardial revascularization surgery (34.6% and valvular surgery (32.8%. Besides the routine evaluation of the data observed in these cases, we monitored pump rotational speed, blood flow, cardiopulmonary bypass duration, urine free hemoglobin for blood cell trauma analysis (+ to 4+, lactate desidrogenase (UI/L, fibrinogen level (mg/dL and platelet count (nº/mm3. Results: Besides maintaining appropriate blood pressure and metabolic parameters it was also observed that the Free Hemoglobin levels remained normal, with a slight increase after 90 minutes of cardiopulmonary bypass. The Lactate Dehydrogenase showed an increase, with medians varying between 550-770 IU/L, whereas the decrease in Fibrinogen showed medians of 130-100 mg/dl. The number of platelets showed a slight decrease with the medians ranging from 240,000 to 200,000/mm3. No difficulty was observed during perfusion terminations, nor were there any immediate deaths, and all patients except one, were discharged in good condition. CONCLUSION: The Spiral Pump, as blood propeller during cardiopulmonary bypass, demonstrated to be reliable and safe, comprising in a good option as original and national product for this kind of application.

Effect of Centrifuge Temperature on Routine Coagulation Tests.

Science.gov (United States)

Yazar, Hayrullah; Özdemir, Fatma; Köse, Elif

2018-01-01

This study investigated the effects of cooled and standard centrifuges on the results of coagulation tests to examine the effects of centrifugation temperature. Equal-volume blood samples from each patient were collected at the same time intervals and subjected to standard (25°C) and cooled centrifugation (2-4°C). Subsequently, the prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer values were determined in runs with the same lot numbers in the same coagulation device using the Dia-PT R (PT and INR), Dia-PTT-liquid (aPTT), Dia-FIB (fibrinogen), and Dia-D-dimer kits, respectively. The study enrolled 771 participants. The PT was significantly (p centrifuges were as follows: PT 10.30 versus 10.50 s; PT (INR) 1.04 versus 1.09 s; APTT 28.90 versus 29.40 s; fibrinogen 321.5 versus 322.1 mg/dL; and D-dimer 179.5 versus 168.7 µg FEU/mL. There were significant differences (p centrifuges. Centrifuge temperature can have a significant effect on the results of coagulation tests. However, broad and specific disease-based studies are needed. © 2018 S. Karger AG, Basel.

Centrifugal pump’s impeller optimization using methods of calculation hydrodynamics

Science.gov (United States)

Grigoriev, S.; Mayorov, S.; Polyakov, R.

2017-08-01

The paper features the results of the fluid flow calculation in the channels of varying geometry of the centrifugal pump for the service water in the methanol production chain. Modeling of the flow in ANSYS CFX allowed developing recommendations on adjusting the impeller’s profile, significantly decrease the cavitation wear and increase the lifetime by several times.

Determination of Volumetric Losses in Hydrodynamic Pump Using Numerical Modelling

Directory of Open Access Journals (Sweden)

Lukáš ZAVADIL

2012-06-01

Full Text Available This paper deals with the numerical modelling of the flow in the single-stage centrifugal pump. The main objective is to determine leakage losses through annular seals at the suction side of the pump. Leakage through a shaft seal is not included in the simulation. The amount of liquid that circulates from the impeller discharge back to suction of the pump is determined in dependence on the flow rate. Losses in the pump are further discussed as well as the possibility of their prediction.

Prediction of rotating stall within an impeller of a centrifugal pump based on spectral analysis of pressure and velocity data

International Nuclear Information System (INIS)

Ullum, Ulrik; Wright, Jennifer; Dayi, Oguz; Ecder, Ali; Soulaimani, Azzeddine; Piche, Robert; Kamath, Hemant

2006-01-01

Experimental data, which was acquired in two centrifugal pumps and provided by Grundfos A/S, were analysed to determine if rotating stall could be detected from the velocity and pressure time series. The pressure data, which were uniformly acquired in time at high sample rates(10 kHz), were measured simultaneously in four adjacent di.user channels just downstream of the impeller outlet. The velocity data, which were non-uniformly sampled in time at fairly low rates(100 Hz to 3.5 kHz), were acquired either in or downstream of the impeller. Two di.erent methodologies were employed for detection of stall. The first method, which involved direct analysis of raw data, yielded qualitatively useful flow reversal information from the time series for the radial velocity. The second approach, which was based on power spectrum analysis of velocity and pressure data, could detect the onset and identify the frequency of rotating stall to a satisfactory extent in one of the two pumps. Nearly identical stall frequencies were observed in both velocity and pressure power spectra and this rotating stall phenomenon, which occurred at a very low frequency relative to the impeller speed, did not reveal any noticeable degree of sensitivity to the flow rate. In the other pump, where the available data was limited to velocity time series, the power spectrum analysis was successful in detecting stationary stall for a 6 bladed impeller but did not provide conclusive results for the existence of stall in the case of the 7 bladed impeller. Recommendations on the type of experimental data required for accurate detection of stall are provided based upon the present study

Simulated stand tests and centrifuge training to prevent orthostatic intolerance on Earth, moon, and Mars.

Science.gov (United States)

Coats, Brandon W; Sharp, M Keith

2010-03-01

One proposed method to overcome postflight orthostatic intolerance is for astronauts to undergo inflight centrifugation. Cardiovascular responses were compared between centrifuge and gravitational conditions using a seven-compartment cardiovascular model. Vascular resistance, heart rate, and stroke volume values were adopted from literature, while compartmental volumes and compliances were derived from impedance plethysmography of subjects (n=8) riding on a centrifuge. Three different models were developed to represent the typical male subject who completed a 10-min postflight stand test ("male finisher"), "non-finishing male" and "female" (all non-finishers). A sensitivity analysis found that both cardiac output and arterial pressure were most sensitive to total blood volume. Simulated stand tests showed that female astronauts were more susceptible to orthostatic intolerance due to lower initial blood pressure and higher pressure threshold for presyncope. Rates of blood volume loss by capillary filtration were found to be equivalent in female and male non-finishers, but four times smaller in male finishers. For equivalent times to presyncope during centrifugation as those during constant gravity, lower G forces at the level of the heart were required. Centrifuge G levels to match other cardiovascular parameters varied depending on the parameter, centrifuge arm length, and the gravity level being matched.

Optimization of Power Consumption for Centrifugation Process Based on Attenuation Measurements

Science.gov (United States)

Salim, M. S.; Abd Malek, M. F.; Sabri, Naseer; Omar, M. Iqbal bin; Mohamed, Latifah; Juni, K. M.

2013-04-01

The main objective of this research is to produce a mathematical model that allows decreasing the electrical power consumption of centrifugation process based on attenuation measurements. The centrifugation time for desired separation efficiency may be measured to determine the power consumed of laboratory centrifuge device. The power consumption is one of several parameters that affect the system reliability and productivity. Attenuation measurements of wave propagated through blood sample during centrifugation process were used indirectly to measure the power consumption of device. A mathematical model for power consumption was derived and used to modify the speed profile of centrifuge controller. The power consumption model derived based on attenuation measurements has successfully save the power consumption of centrifugation process keeping high separation efficiency. 18kW.h monthly for 100 daily time device operation had been saved using the proposed model.

Optimization of Power Consumption for Centrifugation Process Based on Attenuation Measurements

International Nuclear Information System (INIS)

Salim, M S; Iqbal bin Omar, M; Malek, M F Abd; Mohamed, Latifah; Sabri, Naseer; Juni, K M

2013-01-01

The main objective of this research is to produce a mathematical model that allows decreasing the electrical power consumption of centrifugation process based on attenuation measurements. The centrifugation time for desired separation efficiency may be measured to determine the power consumed of laboratory centrifuge device. The power consumption is one of several parameters that affect the system reliability and productivity. Attenuation measurements of wave propagated through blood sample during centrifugation process were used indirectly to measure the power consumption of device. A mathematical model for power consumption was derived and used to modify the speed profile of centrifuge controller. The power consumption model derived based on attenuation measurements has successfully save the power consumption of centrifugation process keeping high separation efficiency. 18kW.h monthly for 100 daily time device operation had been saved using the proposed model.

Expert system for the diagnosis of the condition and performance of centrifugal pumps

Energy Technology Data Exchange (ETDEWEB)

Jantunen, E; Vaehae-Pietilae, K; Pesonen, K [Technical Research Centre of Finland, Manufacturing Technology, Espoo (Finland)

1998-12-31

A brief description of the results of a study concerning the maintenance and downtime costs in Finnish pumping is given. The leakage of seals was found to be the fault that causes the highest downtime and maintenance costs. A small laboratory arrangement has been used to test the effectiveness of various condition monitoring methods. This information has been used in the development of a diagnostic expert system called CEPDIA, which can be used for diagnosing the condition of a pump and its components. The diagnosis is based on measuring results obtained from sensors and on information about maintenance actions carried out with the pump and its components. The principles of the CEPDIA expert system are described. A database is included in the system for handling and saving the measurement results, technical information on the pumps and maintenance actions carried out with the pumps. The diagnosis can also be based on vibration signature analysis, which is quite effective in determining which fault is the actual cause of malfunction of the pump or its components. CEPDIA can also be used to calculate of the efficiency of the electrical motor and the pump. CEPDIA has been tested in the diagnosis of 63 pumps. The average efficiency in pumping was less than 40 %, and more than 10 % of the pumps were pumping with less than 10 % efficiency. (orig.) 11 refs.

Expert system for the diagnosis of the condition and performance of centrifugal pumps

Energy Technology Data Exchange (ETDEWEB)

Jantunen, E.; Vaehae-Pietilae, K.; Pesonen, K. [Technical Research Centre of Finland, Manufacturing Technology, Espoo (Finland)

1997-12-31

A brief description of the results of a study concerning the maintenance and downtime costs in Finnish pumping is given. The leakage of seals was found to be the fault that causes the highest downtime and maintenance costs. A small laboratory arrangement has been used to test the effectiveness of various condition monitoring methods. This information has been used in the development of a diagnostic expert system called CEPDIA, which can be used for diagnosing the condition of a pump and its components. The diagnosis is based on measuring results obtained from sensors and on information about maintenance actions carried out with the pump and its components. The principles of the CEPDIA expert system are described. A database is included in the system for handling and saving the measurement results, technical information on the pumps and maintenance actions carried out with the pumps. The diagnosis can also be based on vibration signature analysis, which is quite effective in determining which fault is the actual cause of malfunction of the pump or its components. CEPDIA can also be used to calculate of the efficiency of the electrical motor and the pump. CEPDIA has been tested in the diagnosis of 63 pumps. The average efficiency in pumping was less than 40 %, and more than 10 % of the pumps were pumping with less than 10 % efficiency. (orig.) 11 refs.

Large eddy simulation in a rotary blood pump: Viscous shear stress computation and comparison with unsteady Reynolds-averaged Navier-Stokes simulation.

Science.gov (United States)

Torner, Benjamin; Konnigk, Lucas; Hallier, Sebastian; Kumar, Jitendra; Witte, Matthias; Wurm, Frank-Hendrik

2018-06-01

Numerical flow analysis (computational fluid dynamics) in combination with the prediction of blood damage is an important procedure to investigate the hemocompatibility of a blood pump, since blood trauma due to shear stresses remains a problem in these devices. Today, the numerical damage prediction is conducted using unsteady Reynolds-averaged Navier-Stokes simulations. Investigations with large eddy simulations are rarely being performed for blood pumps. Hence, the aim of the study is to examine the viscous shear stresses of a large eddy simulation in a blood pump and compare the results with an unsteady Reynolds-averaged Navier-Stokes simulation. The simulations were carried out at two operation points of a blood pump. The flow was simulated on a 100M element mesh for the large eddy simulation and a 20M element mesh for the unsteady Reynolds-averaged Navier-Stokes simulation. As a first step, the large eddy simulation was verified by analyzing internal dissipative losses within the pump. Then, the pump characteristics and mean and turbulent viscous shear stresses were compared between the two simulation methods. The verification showed that the large eddy simulation is able to reproduce the significant portion of dissipative losses, which is a global indication that the equivalent viscous shear stresses are adequately resolved. The comparison with the unsteady Reynolds-averaged Navier-Stokes simulation revealed that the hydraulic parameters were in agreement, but differences for the shear stresses were found. The results show the potential of the large eddy simulation as a high-quality comparative case to check the suitability of a chosen Reynolds-averaged Navier-Stokes setup and turbulence model. Furthermore, the results lead to suggest that large eddy simulations are superior to unsteady Reynolds-averaged Navier-Stokes simulations when instantaneous stresses are applied for the blood damage prediction.

Simple tube centrifugation for processing platelet-rich plasma in the horse.

Science.gov (United States)

Fontenot, Robin L; Sink, Carolyn A; Werre, Stephen R; Weinstein, Nicole M; Dahlgren, Linda A

2012-12-01

This study evaluated the quality and bacteriologic safety of platelet-rich plasma (PRP) produced by 3 simple, inexpensive tube centrifugation methods and a commercial system. Citrated equine blood collected from 26 normal horses was processed by 4 methods: blood collection tubes centrifuged at 1200 and 2000 × g, 50-mL conical tube, and a commercial system. White blood cell (WBC), red blood cell (RBC), and platelet counts and mean platelet volume (MPV) were determined for whole blood and PRP, and aerobic and anaerobic cultures were performed. Mean platelet concentrations ranged from 1.55- to 2.58-fold. The conical method yielded the most samples with platelet concentrations greater than 2.5-fold and within the clinically acceptable range of > 250,000 platelets/μL. White blood cell counts were lowest with the commercial system and unacceptably high with the blood collection tubes. The conical tube method may offer an economically feasible and comparatively safe alternative to commercial PRP production systems.

Erythrocyte sedimentation rate and fibrinogen concentration of whole blood influences the cellular composition of platelet-rich plasma obtained from centrifugation methods.

Science.gov (United States)

Yin, Wenjing; Xu, Zhengliang; Sheng, Jiagen; Xie, Xuetao; Zhang, Changqing

2017-09-01

Erythrocyte sedimentation rate (ESR), which reflects the sedimentation rate of platelets, leukocytes and erythrocytes in response to centrifugal force, may influence the cellular composition of platelet-rich plasma (PRP) obtained via centrifugation methods. However, no relevant studies have substantiated this. In the present study, blood was collected from 40 healthy volunteers and used to prepare PRP with two plasma-based preparation systems [YinPRP and Plasma Rich in Growth Factor (PRGF) systems] and two buffy coat-based systems (RegenPRP and WEGOPRP systems) in a single-donor model. Volumes of PRP and platelet-poor plasma (PPP) that were removed in the preparation process were recorded. Analyses of ESR, haematocrit, C-reaction protein, coagulation, serum glucose and serum lipid of the whole blood used for PRP preparation were performed to evaluate the levels of ESR and the factors known to influence it. Whole blood analysis was performed to evaluate the cellular composition of PRP. Results demonstrated that there were marked positive correlations between the ESR of the whole blood used for PRP preparation and PPP removal efficiencies, platelet concentrations, platelet capture efficiencies and platelet enrichment factors of PRP formulations obtained from plasma-based systems, and PRP yield efficiency of RegenPRP and PPP removal efficiency of WEGOPRP. Furthermore, there were marked negative correlations between ESR and concentrations and enrichment factors of platelets, leukocytes and erythrocytes of RegenPRP. Fibrinogen concentration of the whole blood, which had a marked positive correlation with ESR, also influenced the cellular composition of PRP. These findings may increase the understanding of PRP preparation and provide substantial evidence for the individualised optimisation of PRP preparation systems used in clinical practice.

DOES TRANEXAMIC ACID REDUCE BLOOD LOSS IN OFF-PUMP CORONARY ARTERY BYPASS?

Directory of Open Access Journals (Sweden)

A. Mehr-Aein

2006-09-01

Full Text Available Tranexamic acid is now used on a routine basis for on-pump coronary artery bypass grafting (CABG. We assessed the hemostatic effects of tranexamic acid to decrease bleeding tendency and transfusion requirements in patients undergoing off-pump coronary artery bypass surgery (OPCAB. A total of 66 patients were enrolled to elective OPCAB in a double-blind, prospective randomized study. Of these, 33 patients received tranexamic acid (15 mg/kg before the infusion of heparin and 15 mg/kg after protamin infusion, and 33 patients received only saline. Preoperative hematologic variables, postoperative bleeding and allogeneic transfusions were considered. D-dimer plasma levels were also evaluated to monitor the activation of fibrinolysis. Postoperative bleeding was significantly lower in the tranexamic acid group compared with the control group (320 ± 38 mL vs. 480 ± 75 mL at 12 hour, P < 0.001. The tranexamic acid group had significantly lesser need for allogeneic blood products (0.46 units/patients vs. 0.94 units/patients, P < 0.001. They had also lower post-operative D-dimer plasma levels. No postoperative thrombotic complications were observed in either group. The defective hemostasis occurs even in the OPCABG. Tranexamic acid effectively reduces postoperative blood loss and the need for allogeneic blood products after OPCAB is decreased.

Detection of fungal DNA in lysis-centrifugation blood culture for the diagnosis of invasive candidiasis in neonatal patients.

Science.gov (United States)

Trovato, L; Betta, P; Romeo, M G; Oliveri, S

2012-03-01

We report data concerning the detection of fungal DNA directly from lysis-centrifugation blood culture to assess its value in the detection of fungaemia in 86 of the 347 patients admitted to the neonatal intensive-care unit between January 2009 and December 2010. The sensitivity and specificity of the PCR were 87.5% and 98.5%, respectively, with a positive predictive value of 93.3% and a negative predictive value of 97.1%. Detection of fungal DNA directly from blood culture Isolator 1.5 microbial tubes, without prior cultivation, is a promising approach for the rapid detection of Candida spp. in neonates with suspected candidaemia. © 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.

Centrifuge Techniques and Apparatus for Transport Experiments in Porous Media

Energy Technology Data Exchange (ETDEWEB)

Earl D. Mattson; Carl D. Paler; Robert W. Smith; Markus Flury

2010-06-01

This paper describes experimental approaches and apparatus that we have developed to study solute and colloid transport in porous media using Idaho National Laboratory's 2-m radius centrifuge. The ex-perimental techniques include water flux scaling with applied acceleration at the top of the column and sub-atmospheric pressure control at the column base, automation of data collection, and remote experimental con-trol over the internet. These apparatus include a constant displacement piston pump, a custom designed liquid fraction collector based on switching valve technology, and modified moisture monitoring equipment. Suc-cessful development of these experimental techniques and equipment is illustrated through application to transport of a conservative tracer through unsaturated sand column, with centrifugal acceleration up to 40 gs. Development of such experimental equipment that can withstand high accelerations enhances the centrifuge technique to conduct highly controlled unsaturated solute/colloid transport experiments and allows in-flight liquid sample collection of the effluent.

Pump testing - Comparison of factory vs. field test of centrifugal pumps

International Nuclear Information System (INIS)

Fehlau, R.

1992-01-01

Testing of pumps in situ, i.e., as installed in a system, will typically yield somewhat different performance results from the original manufacturer's factory test. This paper discusses some of the reasons for these variations. It shows that the factory test curves can be used for evaluation of initial acceptance tests but not for reference in normal inservice testing (IST). This is the basis for reference values used in American Society of Mechanical Engineers (ASME) Section 11 specifications and the revised ASME Code 1990

Assessment of centrifugation using for accelerated immunological microarray analysis for blood cells investigation

Directory of Open Access Journals (Sweden)

A. V. Shishkin

2011-01-01

Full Text Available Phase of incubation microarray with cell suspension is prolonged when cells are investigated. It takes from 20 to 60 min if cell sedimentation on the surface of microarray is the result of gravity . Decrease of this stage duration is possible due to centrifugation. In th is article influence of centrifugation on results of analysis is considered. Changes of morphological description of cells are estimated when they a re precipitatedwith different acceleration. Also availability of centrifugation using when it is necessary to obtain the high density of cell binding in test regions of microarray if cells concentration in sample is small is demonstrated.

A magnetic fluid seal for rotary blood pumps: Long-term performance in liquid

Science.gov (United States)

Mitamura, Yoshinori; Takahashi, Sayaka; Amari, Shuichi; Okamoto, Eiji; Murabayashi, Shun; Nishimura, Ikuya

A magnetic fluid (MF) seal enables mechanical contact-free rotation of the shaft and hence has excellent durability. The performance of a MF seal, however, has been reported to decrease in liquids. We have developed a MF seal that has a 'shield' mechanism and a new MF with a higher magnetization of 47.9 kA/m. The sealing performance of the MF seal installed in a rotary blood pump was studied. The seal was perfect against a pressure of 150 mmHg in a continuous flow of 4.0 L/min for 275 days and against a pressure of 175 mmHg in a continuous flow of 3.9 L/min for 217 days. We have developed a MF seal that works in liquid against pressure mostly used clinically. The magnetic fluid seal is promising as a shaft seal for rotary blood pumps.

Cardio-postural interactions and short-arm centrifugation.

Science.gov (United States)

Blaber, Andrew; Goswami, Nandu; Xu, Da; Laurin, Alexendre

INTRODUCTION: We are interested in mechanisms associated with orthostatic tolerance. In previous studies we have shown that postural muscles in the calf contribute to both posture and blood pressure regulation during orthostatic stress. In this study we investigated the relationship between cardiovascular and postural muscle control before, during and after short arm human centrifuge (SAHC) up to 2.2 G. METHODS: Eleven healthy young subjects (6 m, 5 f), with no history of cardiovascular disease, falls or orthostatic hypotension, participated. All were familiarized with the SAHC with 10 minutes at 1-G at the feet. Each subject was instrumented in the supine position on the SAHC for beat-to-beat ECG and blood pressure (Portapres derived SBP). Bilateral lower leg EMG was collected from four leg postural muscles: tibialis anterior, medial gastrocnemius, lateral gastrocnemius, and medial soleus. Transdermal differential recording of signals was performed using an 8-channel EMG system, (Myosystem 1200, Noraxon Inc., Arizona, USA). Postural sway data of the body COP was computed from the force and moment data collected with a force platform (Accusway, AMTI, MA, USA). Before and after SAHC, the subject stood on a force platform with their gaze fixed on a point at eye level, closed their eyes and stood quietly for 5 min. A final stand was conducted 30 min after centrifugation with supine rest in between. During clockwise centrifugation (10-min 1g and 10-min 2.2g at the foot) the subjects’ head was hooded and in the dark. The subject’s body was restrained into the rotation arm with a parachute harness and given additional body support with a foot-plate. ECG, EMG and BP data were collected throughout and centre of pressure trajectory (COP) collected during the stand test. Subjects were requested to relax and not to voluntarily contract the leg muscles; however, they were not to suppress contractions as they occurred involuntarily or by reflex. A Continuous Wavelet

Design optimization of photovoltaic powered water pumping systems

International Nuclear Information System (INIS)

Ghoneim, A.A.

2006-01-01

The use of photovoltaics as the power source for pumping water is one of the most promising areas in photovoltaic applications. With the increased use of water pumping systems, more attention has been paid to their design and optimum utilization in order to achieve the most reliable and economical operation. This paper presents the results of performance optimization of a photovoltaic powered water pumping system in the Kuwait climate. The direct coupled photovoltaic water pumping system studied consists of the PV array, DC motor, centrifugal pump, a storage tank that serves a similar purpose to battery storage and a maximum power point tracker to improve the efficiency of the system. The pumped water is desired to satisfy the domestic needs of 300 persons in a remote area in Kuwait. Assuming a figure of 40 l/person/day for water consumption, a volume of 12 m 3 should be pumped daily from a deep well throughout the year. A computer simulation program is developed to determine the performance of the proposed system in the Kuwait climate. The simulation program consists of a component model for the PV array with maximum power point tracker and component models for both the DC motor and the centrifugal pump. The five parameter model is adapted to simulate the performance of amorphous silicon solar cell modules. The size of the PV array, PV array orientation and the pump-motor-hydraulic system characteristics are varied to achieve the optimum performance for the proposed system. The life cycle cost method is implemented to evaluate the economic feasibility of the optimized photovoltaic powered water pumping system. At the current prices of PV modules, the cost of the proposed photovoltaic powered water pumping system is found to be less expensive than the cost of the conventional fuel system. In addition, the expected reduction in the prices of photovoltaic modules in the near future will make photovoltaic powered water pumping systems more feasible

Microvascular pressure responses of second-generation rats chronically exposed to 2 g centrifugation

Science.gov (United States)

Richardson, D. R.; Knapp, C. F.

1977-01-01

Preliminary results are presented for a study aimed at a quantitative comparison of microvascular dynamics in second-generation rats reared in a 2-g force field produced by centrifugation with similar data from animals reared in a centrifuge that produced only a 1-g force. It is shown that the pressure distribution in the mesenteric microvasculature of the second generation of rats reared in a 2-g environment, as well as the animals' blood pressure response to epinephrine, are significantly different compared to their 1-g counterparts. In particular, 1-g and 2-g chronic centrifugation enhances the arterial blood pressure, and the 2-g force field attenuates the pressor effects of norepinephrine.

Flow behaviour and robustness of non-segregating tailings made from filtered/centrifuged MFT

Energy Technology Data Exchange (ETDEWEB)

Nik, R.M.; Sego, D.C.; Morgenstern, N.R. [Alberta Univ., Edmonton, AB (Canada). Geotechnical Center

2010-07-01

This PowerPoint presentation described an experimental study of a centrifugal dewatering filtration process for mature fine tailings (MFT). Various MFT samples from different oil sands operations were pumped into a filtering centrifuge that produced cake, thin tailings, and filtrate. The MFT was then transformed into non-segregated tailings (NST) and composite tailings (CT). The depositional characteristics of the CT-NST samples were evaluated in a series of flume tests. Flow profiles were presented for various samples. Vane shear tests were also conducted. The yield stress of each sample was compared with its flow duration and solids content. The results of the experimental tests demonstrated that the centrifugal filtration process can be considered as the initial stage of a multi-stage tailings management plan. The filtering centrifuge method can be used to produce robust CTs with higher solids content. Use of the method can decrease the amount of coagulants or flocculants required for further treatment. tabs., figs.

The Generation of Human Induced Pluripotent Stem Cells from Blood Cells: An Efficient Protocol Using Serial Plating of Reprogrammed Cells by Centrifugation

Directory of Open Access Journals (Sweden)

Youngkyun Kim

2016-01-01

Full Text Available Human induced pluripotent stem cells (hiPSCs have demonstrated great potential for differentiation into diverse tissues. We report a straightforward and highly efficient method for the generation of iPSCs from PBMCs. By plating the cells serially to a newly coated plate by centrifugation, this protocol provides multiple healthy iPSC colonies even from a small number of PBMCs. The generated iPSCs expressed pluripotent markers and differentiated into all three germ layer lineages. The protocol can also be used with umbilical cord blood mononuclear cells (CBMCs. In this study, we present a simple and efficient protocol that improved the yield of iPSCs from floating cells such as PBMCs and CBMCs by serial plating and centrifugation.

Heat Generation in Axial and Centrifugal Flow Left Ventricular Assist Devices.

Science.gov (United States)

Yost, Gardner; Joseph, Christine Rachel; Royston, Thomas; Tatooles, Antone; Bhat, Geetha

Despite increasing use of left ventricular assist devices (LVADs) as a surgical treatment for advanced heart failure in an era of improved outcomes with LVAD support, the mechanical interactions between these pumps and the cardiovascular system are not completely understood. We utilized an in vitro mock circulatory loop to analyze the heat production incurred by operation of an axial flow and centrifugal flow LVAD. A HeartMate II and a HeartWare HVAD were connected to an abbreviated flow loop and were implanted in a viscoelastic gel. Temperature was measured at the surface of each LVAD. Device speed and fluid viscosity were altered and, in the HeartMate II, as artificial thrombi were attached to the inflow stator, impeller, and outflow stator. The surface temperatures of both LVADs increased in all trials and reached a plateau within 80 minutes of flow initiation. Rate of heat generation and maximum system temperature were greater when speed was increased, when viscosity was increased, and when artificial thrombi were attached to the HeartMate II impeller. Normal operation of these two widely utilized LVADs results in appreciable heat generation in vitro. Increased pump loading resulted in more rapid heat generation, which was particularly severe when a large thrombus was attached to the impeller of the HeartMate II. While heat accumulation in vivo is likely minimized by greater dissipation in the blood and soft tissues, focal temperature gains with the pump housing of these two devices during long-term operation may have negative hematological consequences.

Computational fluid dynamics analysis of a maglev centrifugal left ventricular assist device.

Science.gov (United States)

Burgreen, Greg W; Loree, Howard M; Bourque, Kevin; Dague, Charles; Poirier, Victor L; Farrar, David; Hampton, Edward; Wu, Z Jon; Gempp, Thomas M; Schöb, Reto

2004-10-01

The fluid dynamics of the Thoratec HeartMate III (Thoratec Corp., Pleasanton, CA, U.S.A.) left ventricular assist device are analyzed over a range of physiological operating conditions. The HeartMate III is a centrifugal flow pump with a magnetically suspended rotor. The complete pump was analyzed using computational fluid dynamics (CFD) analysis and experimental particle imaging flow visualization (PIFV). A comparison of CFD predictions to experimental imaging shows good agreement. Both CFD and experimental PIFV confirmed well-behaved flow fields in the main components of the HeartMate III pump: inlet, volute, and outlet. The HeartMate III is shown to exhibit clean flow features and good surface washing across its entire operating range.

Glucose Pump Test can be Used to Measure Blood Flow Rate of ...

African Journals Online (AJOL)

The aim of study is to determine whether glucose pump test (GPT) is used for surveillance of native AV fistulas by using Doppler US as reference. Methods: In 93 chronic hemodialysis patients with native AV fistula, blood flow rates were measured by Doppler US and GPT. For GPT, glucose was infused to 16 mL/min by ...

Superconducting bearings for a LHe transfer pump

Science.gov (United States)

Kloeppel, S.; Muehsig, C.; Funke, T.; Haberstroh, C.; Hesse, U.; Lindackers, D.; Zielke, S.; Sass, P.; Schoendube, R.

2017-12-01

Superconducting bearings are used in a number of applications for high speed, low loss suspension. Most of these applications suspend a warm shaft and thus require continuous cooling, which leads to additional power consumption. Therefore, it seems advantageous to use these bearings in systems that are inherently cold. One respective application is a submerged pump for the transfer of liquid helium into mobile dewars. Centrifugal pumps require tight sealing clearances, especially for low viscosity fluids and small sizes. This paper covers the design and qualification of superconducting YBCO bearings for a laboratory sized liquid helium transfer pump. Emphasis is given to the axial positioning, which strongly influences the achievable volumetric efficiency.